source
stringclasses 7
values | source_url
stringlengths 33
155
| persistent_id
stringlengths 7
7
| title
stringlengths 3
145
| cui
stringlengths 8
10
⌀ | idx
int64 0
31.8k
| text
stringlengths 31
5.37k
| vector
sequence |
|---|---|---|---|---|---|---|---|
omim | https://www.omim.org/entry/252011 | rowjg6v | MITOCHONDRIAL COMPLEX II DEFICIENCY | C1855008 | 31,757 | mitochondrial complex ii deficiency. mutation was unable to rescue the oxidative growth defect, consistent with a loss of function.
Clinical Management
Bugiani et al. (2006) reported favorable results with oral riboflavin treatment in 2 Italian patients with complex II deficiency. The patients showed acute psychomotor regression in the first year of life, followed by rapidly progressive neurologic deterioration, spastic quadriparesis with dystonic posturing, and mental impairment. One patient was blind. Complex II deficiency was demonstrated in muscle and fibroblasts. Treatment with oral riboflavin resulted in stabilization of the clinical condition and moderate improvement in cognitive and communicative abilities. Riboflavin supplementation to the growth medium of cultured fibroblasts resulted in a 2-fold increase of complex II activity in patient cells but not control cells.
Molecular Genetics
In 2 sibs with complex II deficiency presenting as Leigh syndrome reported by Bourgeois et al. (1992), Bourgeron et al. (1995) identified a homozygous mutation in the SDHA gene (600857.0001) | [
0.05159420147538185,
0.07494960725307465,
0.013242836110293865,
-0.28591296076774597,
0.13703006505966187,
-0.15386733412742615,
-0.06993812322616577,
-0.19718754291534424,
0.027085047215223312,
0.0009408756741322577,
0.011427081190049648,
0.08301703631877899,
0.22631289064884186,
0.08126921951770782,
-0.06069280207157135,
0.2122475802898407,
0.0024860636331140995,
-0.1975712776184082,
-0.03696697950363159,
-0.11752350628376007,
-0.04846581444144249,
-0.08141514658927917,
0.072417713701725,
0.05777163803577423,
0.03496893122792244,
-0.05084293335676193,
0.2057131975889206,
0.1063450425863266,
0.028853215277194977,
0.040712978690862656,
-0.09368894249200821,
-0.15428359806537628,
0.0011430970625951886,
-0.23979470133781433,
0.1694871485233307,
-0.015261024236679077,
-0.07399033010005951,
0.008458917029201984,
0.13301639258861542,
-0.0797322541475296,
-0.15199628472328186,
-0.1463765799999237,
0.2545556128025055,
-0.03713062405586243,
0.41430026292800903,
-0.10088806599378586,
0.020195497199892998,
0.1259714514017105,
0.0719384253025055,
0.19280730187892914,
0.012388579547405243,
0.03017149306833744,
0.1247854232788086,
-0.11728230863809586,
0.2685707211494446,
-0.13049624860286713,
-0.013904397375881672,
0.16940005123615265,
-0.2397785782814026,
-0.17573650181293488,
-0.074396051466465,
0.1937233805656433,
-0.11661435663700104,
-0.12000080943107605,
0.12329193204641342,
-0.10267084091901779,
-0.09845295548439026,
0.1245296373963356,
0.2205585092306137,
0.3446960747241974,
0.26669204235076904,
-0.10434402525424957,
0.1484338492155075,
0.18277506530284882,
0.006774648558348417,
0.012408845126628876,
0.17451095581054688,
0.047523193061351776,
-0.027566682547330856,
-0.2828913629055023,
-0.19479510188102722,
-0.04115958884358406,
-0.004092908464372158,
0.10513902455568314,
0.006872442085295916,
0.27228066325187683,
0.054211392998695374,
0.22494977712631226,
0.04691234976053238,
0.2604953646659851,
0.27983391284942627,
-0.2018418163061142,
-0.003128085983917117,
-0.16912530362606049,
0.12826378643512726,
-0.016129348427057266,
0.21422411501407623,
-0.20039904117584229,
0.051268503069877625,
0.1749299317598343,
0.2518240511417389,
-0.16727013885974884,
-0.17287714779376984,
-0.1638379693031311,
-0.0880400612950325,
0.1490609347820282,
-0.01664828136563301,
0.29761889576911926,
-0.08005628734827042,
0.11098477244377136,
0.16700810194015503,
-0.01550259254872799,
-0.12378410995006561,
-0.07288562506437302,
-0.20846420526504517,
-0.0066273692063987255,
0.11882618069648743,
0.33150967955589294,
-0.01609688438475132,
0.15197576582431793,
-0.0401100292801857,
-0.08300217241048813,
0.23702028393745422,
-0.15137991309165955,
0.07297931611537933,
0.10572045296430588,
0.1308353990316391,
0.10663985460996628,
0.36015602946281433,
-0.14768779277801514,
-0.19068849086761475,
-0.014516406692564487,
-0.32667264342308044,
0.011745985597372055,
-0.14338275790214539,
-0.22497721016407013,
-0.3860419988632202,
-0.13585324585437775,
-0.17164835333824158,
-0.029621627181768417,
-0.07721932977437973,
-0.09500076621770859,
0.19445207715034485,
0.28829696774482727,
0.018130933865904808,
0.057360872626304626,
0.049658484756946564,
-0.0066866399720311165,
0.20845574140548706,
-0.04451880231499672,
0.06670406460762024,
-0.08388202637434006,
0.2931564748287201,
-0.09843570739030838,
-0.15521278977394104,
0.1885841190814972,
-0.008956344798207283,
0.010785871185362339,
-0.2171517014503479,
0.19872409105300903,
0.02854359708726406,
-0.07228301465511322,
-0.06151678040623665,
-0.09749533981084824,
0.054597821086645126,
-0.07351090759038925,
-0.27269405126571655,
0.07674956321716309,
0.14091011881828308,
-0.3986230790615082,
-0.3348540961742401,
0.19278162717819214,
-0.007824963890016079,
0.05177328735589981,
0.4199921786785126,
-0.03611907362937927,
-0.020467936992645264,
0.11021120846271515,
-0.08755268901586533,
0.08685281872749329,
0.20049843192100525,
-0.2549385130405426,
-0.11666454374790192,
0.019213203340768814,
0.22681431472301483,
-0.07614399492740631,
0.16817165911197662,
0.2655758261680603,
-0.2601117491722107,
0.007392356172204018,
0.341679185628891,
0.035990942269563675,
0.1266123205423355,
-0.0425616018474102,
-0.027765769511461258,
-0.12230964750051498,
-0.031378861516714096,
-0.10485619306564331,
-0.15691033005714417,
0.19210991263389587,
0.21074306964874268,
-0.028403760865330696,
0.08788157254457474,
-0.12781648337841034,
-0.23961828649044037,
0.019068561494350433,
-0.05788968503475189,
-0.13782165944576263,
-0.13317729532718658,
0.07096029818058014,
-0.1330990195274353,
0.29305317997932434,
-0.26088690757751465,
0.11585458368062973,
-0.18222171068191528,
-0.08648546040058136,
0.09911463409662247,
-0.005592729430645704,
-0.04421637952327728,
0.0402866005897522,
0.08506370335817337,
-0.08196929842233658,
-0.09523165225982666,
-0.19543366134166718,
-0.08950233459472656,
0.2964552342891693,
-0.2676005959510803,
-0.13826705515384674,
0.10316123068332672,
0.08436285704374313,
0.0985112339258194,
-0.13398602604866028,
-0.01839752495288849,
-0.1108664870262146,
-0.04570840671658516,
-0.24877408146858215,
-0.12096665054559708,
0.18771347403526306,
-0.05833170562982559,
-0.14446911215782166,
-0.49132469296455383,
-0.1058633103966713,
-0.2298196405172348,
0.32153603434562683,
0.018513895571231842,
0.20001094043254852,
-0.1756606101989746,
0.0543174222111702,
0.13610783219337463,
0.15796694159507751,
-0.12306591868400574,
0.10773608833551407,
0.1345260739326477,
-0.2465679794549942,
-0.20778736472129822,
-0.1409733146429062,
0.025437265634536743,
-0.008631264790892601,
0.11497374624013901,
0.05739405006170273,
0.10256095975637436,
0.11364954710006714,
-0.17143192887306213,
0.024927493184804916,
-0.2897554636001587,
0.06742723286151886,
-0.311617910861969,
0.12697777152061462,
-0.08448168635368347,
-0.4144279360771179,
-0.24084258079528809,
0.19451503455638885,
0.16589170694351196,
0.002485920675098896,
0.05181485414505005,
-0.04479045793414116,
-0.051333822309970856,
0.009636124595999718,
0.18304479122161865,
-0.08035942167043686,
0.0389530174434185,
0.08163139969110489,
-0.26095083355903625,
0.040084972977638245,
0.3857218027114868,
-0.03213728591799736,
0.17176957428455353,
0.151821568608284,
-0.08841422200202942,
0.1941898763179779,
-0.10995832085609436,
0.16514697670936584,
-0.06474684923887253,
-0.1653076857328415,
0.09809648990631104,
0.09444206207990646,
0.2254861295223236,
-0.0615738108754158,
0.08824174106121063,
-0.24215207993984222,
0.15469539165496826,
0.0077881175093352795,
0.22637788951396942,
-0.14026600122451782,
-0.2432069182395935,
-0.004740671720355749,
0.09999793767929077,
0.1301102489233017,
0.018477097153663635,
0.17344585061073303,
-0.3413175344467163,
-0.03627331554889679,
-0.06948558241128922,
0.1805613487958908,
-0.04732119292020798,
-0.1686859428882599,
-0.1782020777463913,
0.20903338491916656,
0.06734911352396011,
0.04206616058945656,
0.04769241437315941,
0.15030014514923096,
0.12786541879177094,
-0.009372668340802193,
-0.02790350466966629,
0.062317412346601486,
0.0004233256622683257,
0.06501032412052155,
-0.28780296444892883,
0.2937524616718292,
0.161024808883667,
0.027742397040128708,
-0.18731284141540527,
-0.0951450765132904,
-0.03317168727517128,
0.21719712018966675,
0.2036118507385254,
0.08619062602519989,
-0.35814788937568665,
-0.172843798995018,
0.09716582298278809,
-0.2281554788351059,
-0.08727019280195236,
-0.33528125286102295,
-0.0829886794090271,
0.0446661040186882,
-0.07097300887107849,
0.11271108686923981,
0.24232929944992065,
-0.08441143482923508,
-0.05296451970934868,
0.17189550399780273,
-0.1350449025630951,
-0.12235812842845917,
-0.010084069333970547,
-0.12830591201782227,
-0.1571136713027954,
0.14095360040664673,
0.00947496946901083,
0.00045935643720440567,
0.008990870788693428,
-0.044751156121492386,
0.04823040962219238,
0.0631890520453453,
0.03741328418254852,
0.016224266961216927,
0.05465473607182503,
-0.018838997930288315,
0.07409846037626266,
-0.07251419872045517,
-0.11899351328611374,
-0.08436137437820435,
-0.12175747752189636,
-0.08955133706331253,
-0.19458365440368652,
-0.07759077847003937,
-0.2493070513010025,
0.16802696883678436,
0.08534680306911469,
0.009783674962818623,
-0.1197434738278389,
0.215897798538208,
0.05686979740858078,
0.03282984718680382,
-0.08187199383974075,
0.1986834555864334,
-0.2178763747215271,
0.15350495278835297,
0.3139090836048126,
-0.20322279632091522,
-0.12400058656930923,
0.12065216898918152,
0.15370473265647888,
0.11130663007497787,
-0.027870826423168182,
0.1437598168849945,
-0.1621013730764389,
0.015165501274168491,
-0.06246965005993843,
-0.046409815549850464,
0.08781401813030243,
-0.29128530621528625,
0.23882107436656952,
0.2698022425174713,
0.016999678686261177,
0.21895918250083923,
0.047293052077293396,
0.3137367069721222,
-0.36606359481811523,
-0.06207656487822533,
-0.29654431343078613,
-0.08792643249034882,
-0.06805874407291412,
-0.10666745156049728,
-0.008995047770440578,
-0.06713775545358658,
0.07562725991010666,
0.1748223900794983,
-0.08714502304792404,
0.01941383071243763,
-0.04803632199764252,
-0.26686564087867737,
0.21532320976257324,
-0.08233259618282318,
-0.021128229796886444,
-0.10291251540184021,
-0.07323504239320755,
0.08535010367631912,
0.042052119970321655,
-0.12364225834608078,
0.060095466673374176,
-0.020589543506503105,
-0.17538762092590332,
0.159230574965477,
0.12866823375225067,
0.1271471083164215,
-0.007599035277962685,
0.024812420830130577,
-0.06756371259689331,
0.10831497609615326,
-0.007389283273369074,
0.07834398746490479,
0.1498076319694519,
0.015141384676098824,
-0.20327629148960114,
0.02777785062789917,
0.04085572063922882,
0.29626619815826416,
-0.00577198714017868,
0.18887726962566376,
0.06452343612909317,
0.060110822319984436,
0.0066390992142260075,
-0.06444080919027328,
-0.1414603590965271,
0.18063999712467194,
0.07015541940927505,
-0.16278085112571716,
0.05358182638883591,
-0.2773619592189789,
0.10169550031423569,
0.09125953167676926,
0.017763759940862656,
-0.089657261967659,
-0.036443620920181274,
0.24118654429912567,
-0.16711771488189697,
-0.07350239157676697,
0.22685085237026215,
-0.020235957577824593,
0.1840754747390747,
-0.06512343883514404,
-0.14937955141067505,
0.0799081102013588,
-0.1497247964143753,
0.06668803840875626,
0.09773662686347961,
0.07179867476224899,
0.3249119222164154,
0.1609206646680832,
-0.04476572200655937,
-0.15606024861335754,
-0.30533796548843384,
0.03087451681494713,
-0.06254135817289352,
0.04678596183657646,
-0.1673281341791153,
-0.2757149636745453,
0.17423571646213531,
-0.12353719770908356,
-0.04857060685753822,
-0.11435302346944809,
0.10187029093503952,
0.1255340576171875,
-0.1120210587978363,
0.050320979207754135,
-0.016333986073732376,
-0.09333563596010208,
-0.20876529812812805,
-0.020660601556301117,
0.04104272648692131,
-0.02426675334572792,
-0.013173776678740978,
0.1354735940694809,
-0.06104837730526924,
-0.04025011882185936,
-0.043755389750003815,
-0.4524356722831726,
-0.1345345824956894,
0.49121567606925964,
0.03252004086971283,
-0.023939477279782295,
0.04209544509649277,
-0.05837370082736015,
-0.02773614227771759,
-0.09705185890197754,
0.1376754194498062,
0.04745842516422272,
0.20225776731967926,
-0.1792968362569809,
-0.002298705279827118,
0.05554039403796196,
0.5435799360275269,
0.05785117670893669,
0.09062892198562622,
-0.11793062835931778,
0.015550551936030388,
0.08502781391143799,
-0.007097749970853329,
-0.1426570862531662,
-0.028586454689502716,
-0.0038860768545418978,
-0.16025273501873016,
0.045830197632312775,
0.031091047450900078,
0.02200232446193695,
0.14205299317836761,
-0.2048291712999344,
-0.02840127795934677,
0.026109926402568817,
-0.086443692445755,
-0.034748345613479614,
-0.026874437928199768,
0.11008242517709732,
-0.03221949189901352,
-0.10994605720043182,
-0.13312391936779022,
-0.12985928356647491,
0.0655008852481842,
0.22519265115261078,
-0.2135697603225708,
-0.0074386741034686565,
0.1853104531764984,
0.06129693612456322,
-0.3447663486003876,
-0.05633373185992241,
0.07998736947774887,
-0.12506985664367676,
0.015658525750041008,
-0.07135481387376785,
0.12134068459272385,
0.12206458300352097,
0.14847467839717865,
0.06668365001678467,
-0.0976509153842926,
0.11802622675895691,
0.07691314071416855,
-0.007450877223163843,
-0.03062034584581852,
-0.18647046387195587,
0.04229069501161575,
-0.07355036586523056,
-0.20120389759540558,
0.12008000165224075,
-0.3022867441177368,
0.028383707627654076,
-0.02096991054713726,
-0.12513677775859833,
-0.032941948622465134,
0.13932430744171143,
0.15310637652873993,
0.04471677541732788,
-0.03163931146264076,
-0.07513877004384995,
-0.09645930677652359,
-0.12618044018745422,
-0.020299436524510384,
0.07914941012859344,
0.10434315353631973,
0.060310494154691696,
0.2154148519039154,
0.04574083536863327,
-0.022753318771719933,
-0.06808380782604218,
0.09718984365463257,
-0.19839511811733246,
0.12698908150196075,
-0.08809801936149597,
0.022994428873062134,
0.24214372038841248,
-0.08010406047105789,
0.315595805644989,
0.008186439983546734,
-0.045926302671432495,
0.21787524223327637,
0.18678390979766846,
0.13295820355415344,
-0.012246997095644474,
0.030391454696655273,
0.1553041934967041,
0.09596647322177887,
-0.18218643963336945,
0.035397231578826904,
0.0018759481608867645,
0.1703946739435196,
0.12189534306526184,
0.07286638766527176,
-0.048950135707855225,
0.3439525067806244,
0.06212223321199417,
0.28043505549430847,
0.022093337029218674,
0.1893400400876999,
-0.2233438640832901,
-0.09026490151882172,
-0.05887257680296898,
0.09807730466127396,
-0.11932829767465591,
0.2278416007757187,
-0.12669652700424194,
-0.054403290152549744,
0.08685661852359772,
0.28520146012306213,
-0.03863053023815155,
-0.01428377628326416,
0.11113910377025604,
0.06920944154262543,
0.13311803340911865,
-0.041533201932907104,
-0.21637138724327087,
-0.15114973485469818,
0.0024231551215052605,
-0.16574783623218536,
0.31350356340408325,
-0.19467902183532715,
-0.09787813574075699,
0.04789624735713005,
-0.004634164739400148,
-0.058736126869916916,
-0.05313683673739433,
0.13227872550487518,
-0.1192324310541153,
-0.3008096218109131,
0.23196697235107422,
0.014835632406175137,
-0.11925934255123138,
-0.08404091745615005,
-0.031061474233865738,
-0.10038264095783234,
-0.00976472720503807,
-0.1771707683801651,
-0.0003403656301088631,
0.030189339071512222,
0.16505447030067444,
0.01885942742228508,
0.06742828339338303,
0.08277494460344315,
0.15738627314567566,
-0.28644323348999023,
-0.24622780084609985,
-0.03590024262666702,
0.05820443108677864,
0.040905725210905075,
-0.006988253444433212,
0.24768014252185822,
-0.02111097052693367,
-0.16752085089683533,
-0.15640634298324585,
-0.2514801621437073,
0.08451820909976959,
0.029166825115680695,
-0.2165229171514511,
-0.18842023611068726,
0.047276780009269714,
0.08135566860437393,
0.2522033154964447,
0.014137636870145798,
-0.0666159987449646,
0.37995797395706177,
-0.04681657999753952,
-0.07749203592538834,
0.16373464465141296,
0.15056532621383667,
0.2324802428483963,
-0.1323009729385376,
0.05514109507203102,
0.4481578767299652,
0.00014310267579276115,
-0.3141407072544098,
-0.21566241979599,
-0.08757506310939789,
0.1876869797706604,
-0.2510760426521301,
0.05858433246612549,
-0.11224819719791412,
0.1514362096786499,
-0.10160931944847107,
-0.27227574586868286,
-0.040923841297626495,
0.12453892827033997,
0.13966141641139984,
0.18214911222457886,
-0.2292335480451584,
0.1560421884059906,
0.12050770223140717,
0.01580018736422062,
-0.027109771966934204,
-0.060411591082811356,
0.14705801010131836,
-0.06844966858625412,
-0.023454660549759865,
-0.09998204559087753,
0.307497501373291,
0.0005575451068580151,
0.09360626339912415,
0.08723469823598862,
0.1062193512916565,
0.08553863316774368,
0.1937791258096695,
0.05446549504995346,
-0.19135822355747223,
0.06337901949882507,
-0.12872788310050964,
0.06105607748031616,
-0.14846359193325043,
-0.043920401483774185,
0.22259853780269623,
0.1298273503780365,
-0.07291625440120697,
-0.059778548777103424,
0.2807998061180115,
0.21674662828445435,
-0.002600958803668618,
0.02571328729391098,
0.008480800315737724,
0.01025775820016861,
-0.0026962028350681067,
0.16723407804965973,
0.057222720235586166,
-0.09565362334251404,
0.10217849165201187,
0.17122484743595123,
0.18337245285511017,
-0.08286739885807037,
-0.06596220284700394,
0.043182287365198135,
-0.19055679440498352,
-0.3448411226272583,
0.37315455079078674,
0.08035426586866379,
0.013218432664871216,
-0.07336761057376862,
-0.10798057913780212,
0.03159157559275627,
-0.1348334103822708,
0.15731798112392426,
-0.23938505351543427,
0.013978357426822186
] |
omim | https://www.omim.org/entry/252011 | rowjg6v | MITOCHONDRIAL COMPLEX II DEFICIENCY | C1855008 | 31,757 | mitochondrial complex ii deficiency. Treatment with oral riboflavin resulted in stabilization of the clinical condition and moderate improvement in cognitive and communicative abilities. Riboflavin supplementation to the growth medium of cultured fibroblasts resulted in a 2-fold increase of complex II activity in patient cells but not control cells.
Molecular Genetics
In 2 sibs with complex II deficiency presenting as Leigh syndrome reported by Bourgeois et al. (1992), Bourgeron et al. (1995) identified a homozygous mutation in the SDHA gene (600857.0001). Bourgeron et al. (1995) claimed that this was the first report of a nuclear gene mutation causing a mitochondrial respiratory chain deficiency in humans. In affected members of an Italian and Turkish family with mitochondrial complex II deficiency, Ghezzi et al. (2009) identified 2 different homozygous mutations in the SDHAF1 gene (612848.0001 and 612848.0002, respectively). Some of patients had been reported by Brockmann et | [
0.07056271284818649,
0.11876313388347626,
0.20191381871700287,
-0.3051426112651825,
0.21294023096561432,
-0.18389418721199036,
0.038672540336847305,
-0.1705167144536972,
-0.03614948317408562,
-0.04406767711043358,
-0.013039587065577507,
0.16712500154972076,
0.13287362456321716,
0.0852319672703743,
0.14693082869052887,
0.1402157098054886,
0.09608199447393417,
-0.240645170211792,
-0.04619249328970909,
-0.028541037812829018,
-0.05695943161845207,
-0.08285992592573166,
0.18597440421581268,
0.05323139205574989,
0.05934492126107216,
-0.08913696557283401,
0.1671096533536911,
0.041266895830631256,
0.011967096477746964,
0.0666269063949585,
-0.0753777027130127,
-0.20303286612033844,
-0.06457982957363129,
-0.3253190219402313,
0.13234874606132507,
-0.039843373000621796,
-0.12874074280261993,
0.02397153712809086,
0.16626191139221191,
-0.19056817889213562,
-0.09762554615736008,
0.03855196014046669,
0.12888683378696442,
0.07278207689523697,
0.13763396441936493,
0.03289330378174782,
0.13348563015460968,
0.017255891114473343,
0.14825265109539032,
0.20877040922641754,
0.047460153698921204,
0.05418585240840912,
0.20916420221328735,
-0.25672203302383423,
0.2994726002216339,
-0.09823670238256454,
0.10034069418907166,
0.08888913691043854,
-0.28286421298980713,
-0.21613718569278717,
-0.12024835497140884,
0.2943846583366394,
-0.1362215131521225,
-0.09834582358598709,
0.12276849150657654,
0.07503356039524078,
-0.11650633066892624,
0.22880639135837555,
0.15041504800319672,
0.23194573819637299,
0.28946059942245483,
-0.08322034776210785,
0.11369359493255615,
0.11940469592809677,
-0.040202900767326355,
0.190641388297081,
0.16610823571681976,
-0.016221018508076668,
0.07790789008140564,
-0.2713046967983246,
-0.14259500801563263,
0.05500274524092674,
0.04806354269385338,
0.2137024998664856,
0.052522141486406326,
0.25296759605407715,
0.0556778684258461,
0.19230963289737701,
0.010158860124647617,
0.2483985424041748,
0.10945913940668106,
-0.04446662217378616,
0.041785579174757004,
-0.10918381810188293,
0.07351411134004593,
-0.004362506326287985,
0.17273259162902832,
-0.10876774787902832,
-0.03558075800538063,
0.1819186806678772,
0.20893530547618866,
-0.1707349717617035,
-0.11949990689754486,
-0.1271553486585617,
0.11665423214435577,
0.0027278049383312464,
-0.17043200135231018,
0.1661587357521057,
-0.0853532999753952,
0.0634937435388565,
0.02266501449048519,
0.138387069106102,
-0.24400685727596283,
0.003057472873479128,
-0.05643206462264061,
0.003965450916439295,
0.21455951035022736,
0.25707289576530457,
-0.006572506856173277,
0.09973148256540298,
-0.15599219501018524,
-0.018838711082935333,
0.1108207106590271,
-0.13383784890174866,
-0.0015825178707018495,
0.08888372033834457,
0.19408409297466278,
0.08622260391712189,
0.3619270622730255,
-0.08087269961833954,
-0.22295214235782623,
0.05787276476621628,
-0.15856026113033295,
0.02010517567396164,
-0.11647628247737885,
-0.21272538602352142,
-0.4421321153640747,
-0.06074026972055435,
-0.09778378903865814,
-0.09212347865104675,
-0.0334286242723465,
-0.17005980014801025,
0.21131207048892975,
0.25530168414115906,
-0.06654606759548187,
0.10697313398122787,
0.07412315160036087,
-0.029903365299105644,
0.14232923090457916,
0.01909075677394867,
0.18366168439388275,
-0.02346612885594368,
0.3809203803539276,
-0.15372087061405182,
-0.13965582847595215,
0.027632076293230057,
-0.024148155003786087,
-0.018960323184728622,
-0.18881767988204956,
0.10184840112924576,
0.06573663651943207,
0.09406361728906631,
-0.025219321250915527,
-0.07690999656915665,
0.2543252110481262,
-0.14411644637584686,
-0.19944973289966583,
0.049400605261325836,
0.000772904371842742,
-0.2112807333469391,
-0.31666332483291626,
0.09761234372854233,
0.018831461668014526,
0.0800027996301651,
0.2741604447364807,
-0.012175725772976875,
-0.1465076357126236,
0.037726592272520065,
-0.08334137499332428,
0.02562573365867138,
0.19149455428123474,
-0.26874664425849915,
-0.12097866088151932,
-0.059614360332489014,
0.02620607428252697,
-0.14418430626392365,
0.23544201254844666,
0.3046315312385559,
-0.22955919802188873,
0.17448590695858002,
0.2477189600467682,
-0.11098527163267136,
0.10896331816911697,
-0.13533969223499298,
0.0014442458050325513,
-0.024767205119132996,
-0.08902622759342194,
-0.1818007081747055,
-0.1665065735578537,
-0.06691418588161469,
0.25623831152915955,
-0.07605206221342087,
0.10493593662977219,
-0.005855460185557604,
-0.06376245617866516,
0.013886716216802597,
-0.05659513548016548,
-0.054882265627384186,
-0.16646933555603027,
0.16498877108097076,
0.013798711821436882,
0.15088877081871033,
-0.20635908842086792,
0.1878974586725235,
-0.22624409198760986,
-0.13893160223960876,
0.11156617850065231,
0.012326633557677269,
-0.011298422701656818,
0.028174975886940956,
0.12947018444538116,
0.02661169320344925,
-0.05396603047847748,
-0.22450320422649384,
0.003732036566361785,
0.295210063457489,
-0.11883381009101868,
-0.08378289639949799,
0.19085317850112915,
0.08171213418245316,
0.15663301944732666,
-0.20091786980628967,
0.0021406542509794235,
-0.08893181383609772,
-0.1278921663761139,
-0.05648102983832359,
0.06968576461076736,
0.11612565070390701,
0.03314818814396858,
0.026793304830789566,
-0.43582260608673096,
-0.06223020702600479,
-0.04607140272855759,
0.17513367533683777,
-0.007863381877541542,
0.05219634622335434,
-0.0661478191614151,
0.009492098353803158,
0.06731334328651428,
0.2524802088737488,
-0.07652772963047028,
0.08647122234106064,
0.011246982961893082,
-0.2065809816122055,
-0.3081608712673187,
-0.1340775340795517,
-0.038705289363861084,
0.0024023628793656826,
-0.0037649699952453375,
0.05055593326687813,
0.14287620782852173,
0.05179079622030258,
-0.08873496204614639,
0.17727626860141754,
-0.23025061190128326,
0.02906501479446888,
-0.21877066791057587,
0.05419592186808586,
-0.12765051424503326,
-0.2396809309720993,
-0.21139545738697052,
0.14067234098911285,
0.12531903386116028,
0.0269952230155468,
-0.010305245406925678,
-0.07217670232057571,
-0.05365661159157753,
0.024353614076972008,
0.23847812414169312,
-0.0249053742736578,
-0.0003032497188542038,
0.013497527688741684,
-0.17831699550151825,
0.110966756939888,
0.29866912961006165,
0.09890762716531754,
0.2561415433883667,
0.12258917093276978,
-0.15768298506736755,
0.13094665110111237,
-0.07982122153043747,
0.16928762197494507,
-0.15141738951206207,
-0.06635426729917526,
0.02446848526597023,
0.11106172949075699,
0.11011417955160141,
-0.09411843866109848,
-0.04278180003166199,
-0.07958582788705826,
0.08631595224142075,
0.00818052887916565,
0.09988869726657867,
-0.19783781468868256,
-0.18101057410240173,
0.1465511918067932,
0.15463417768478394,
0.19143088161945343,
-0.058789413422346115,
0.2573391795158386,
-0.3456304967403412,
-0.07713553309440613,
-0.03619508072733879,
0.10761148482561111,
-0.012584206648170948,
-0.06162917986512184,
-0.17126329243183136,
0.00535853486508131,
-0.02398499846458435,
0.1868361234664917,
0.012533590197563171,
0.1620258390903473,
0.031130274757742882,
0.13438265025615692,
0.013549312017858028,
-0.040352609008550644,
-0.19085820019245148,
0.03829463943839073,
-0.17602162063121796,
0.2452945113182068,
0.14991965889930725,
0.07556833326816559,
-0.13005894422531128,
-0.13036368787288666,
-0.020370805636048317,
0.14471247792243958,
0.08546803146600723,
0.014026853255927563,
-0.29147204756736755,
-0.0020482405088841915,
0.11948041617870331,
-0.09544485807418823,
-0.23628655076026917,
-0.20141127705574036,
0.021267009899020195,
-0.043362099677324295,
0.008272364735603333,
0.03853107988834381,
0.2019229233264923,
-0.1463601440191269,
-0.12830154597759247,
0.08716177195310593,
-0.1270584613084793,
-0.1867043673992157,
0.11433546245098114,
-0.08685208857059479,
-0.23614560067653656,
0.1993715465068817,
0.023614751175045967,
0.007408240810036659,
0.07551587373018265,
0.000364090024959296,
0.21701283752918243,
-0.10619303584098816,
-0.04116090014576912,
0.07495544105768204,
0.22202767431735992,
0.096040740609169,
0.02515236847102642,
0.04209958016872406,
-0.04207956790924072,
0.0021983773913234472,
-0.018069716170430183,
-0.06823581457138062,
-0.1646166890859604,
-0.030314235016703606,
-0.1486121416091919,
0.08853810280561447,
0.0325893834233284,
-0.05939122289419174,
-0.09429994225502014,
0.12444576621055603,
0.12286112457513809,
-0.04932621121406555,
-0.07412475347518921,
0.25251901149749756,
-0.1258673369884491,
0.07278967648744583,
0.09507758915424347,
-0.17935697734355927,
-0.09039340168237686,
0.1335669308900833,
0.08284678310155869,
-0.035756032913923264,
0.08766040205955505,
0.26983150839805603,
-0.039812199771404266,
0.0022772725205868483,
-0.10395415127277374,
-0.06298492103815079,
-0.10605327785015106,
-0.2163868248462677,
0.13372065126895905,
0.24765577912330627,
0.002324408385902643,
0.1729908287525177,
0.13361123204231262,
0.2832137942314148,
-0.2634187936782837,
-0.0796862319111824,
-0.2136221081018448,
-0.009654415771365166,
-0.07014664262533188,
-0.18900156021118164,
-0.09365450590848923,
0.0015675448812544346,
-0.0053224870935082436,
0.2485639899969101,
-0.12908010184764862,
0.07789044827222824,
-0.12037443369626999,
-0.12272943556308746,
0.25162339210510254,
-0.09292707592248917,
-0.07412468641996384,
0.0860203206539154,
0.08761359006166458,
0.05571145936846733,
0.11584462225437164,
-0.1484670490026474,
0.006314724683761597,
-0.17382074892520905,
-0.1507524698972702,
0.045900244265794754,
0.06283746659755707,
0.21534724533557892,
0.16509076952934265,
0.06465251743793488,
-0.109173484146595,
0.11037304997444153,
0.01928800344467163,
0.10988732427358627,
0.05381317064166069,
-0.05471854656934738,
-0.05330488458275795,
0.18159450590610504,
0.13326327502727509,
0.1590828001499176,
-0.0667371079325676,
0.1247461661696434,
0.034829746931791306,
0.05490946024656296,
-0.008985883556306362,
-0.1497347205877304,
-0.16051314771175385,
0.17684213817119598,
0.10282492637634277,
-0.07502061128616333,
0.040159404277801514,
-0.1731901615858078,
0.1749366968870163,
0.026635002344846725,
0.21729490160942078,
-0.056379325687885284,
0.05903284624218941,
0.27556008100509644,
-0.1717546135187149,
-0.05813292786478996,
0.16349190473556519,
-0.05255778506398201,
0.13282740116119385,
-0.07077217847108841,
-0.12087281793355942,
-0.025949085131287575,
-0.13837583363056183,
0.10355725884437561,
0.07688434422016144,
0.015237897634506226,
0.11035673320293427,
0.15551216900348663,
-0.08011233061552048,
-0.06270977109670639,
-0.26184752583503723,
0.1749347299337387,
0.04629366844892502,
-0.03187703713774681,
-0.1304643154144287,
-0.19304987788200378,
0.214895561337471,
-0.06685550510883331,
-0.004903815221041441,
-0.04678618535399437,
0.09181766211986542,
0.17687276005744934,
0.00932985171675682,
0.04447750002145767,
-0.06993058323860168,
-0.12266770005226135,
-0.14070267975330353,
0.05402350053191185,
0.08960427343845367,
-0.027798470109701157,
0.13676732778549194,
0.18580594658851624,
-0.05136120691895485,
-0.14050649106502533,
-0.09305518865585327,
-0.39669522643089294,
0.02629855088889599,
0.4645163118839264,
0.07482975721359253,
-0.06872738152742386,
0.05618390068411827,
-0.1487952023744583,
0.05436266213655472,
-0.1637171059846878,
0.08814531564712524,
0.012027417309582233,
0.19904735684394836,
-0.06638509780168533,
-0.09611499309539795,
-0.17915676534175873,
0.47398123145103455,
0.0020908548031002283,
0.18035559356212616,
-0.16402596235275269,
0.021379102021455765,
0.08721089363098145,
-0.010597601532936096,
-0.2124764621257782,
-0.06473863869905472,
-0.04344810172915459,
-0.27656474709510803,
0.20074515044689178,
0.14188319444656372,
0.07377023994922638,
0.116212859749794,
-0.16240845620632172,
-0.16234250366687775,
0.00029260976589284837,
-0.031090622767806053,
-0.04265861213207245,
-0.09281489998102188,
-0.06664066016674042,
0.07866241037845612,
-0.14960230886936188,
-0.05537714064121246,
-0.07866542786359787,
0.12047837674617767,
0.26930829882621765,
-0.15365202724933624,
-0.027010204270482063,
0.11974096298217773,
0.044526007026433945,
-0.35235700011253357,
-0.022983143106102943,
0.04851318895816803,
-0.027018629014492035,
0.011808075942099094,
-0.09637691080570221,
0.1189957782626152,
0.15241917967796326,
0.076961450278759,
-0.011011555790901184,
0.0011683990014716983,
0.07932798564434052,
0.22154200077056885,
-0.10494140535593033,
0.11096042394638062,
-0.24981506168842316,
-0.02460610866546631,
-0.14005331695079803,
-0.13806824386119843,
0.017392953857779503,
-0.23591549694538116,
0.021631499752402306,
-0.2539255619049072,
-0.1159001812338829,
-0.019563522189855576,
0.10617347061634064,
-0.043236467987298965,
-0.035930827260017395,
-0.09622645378112793,
-0.04535197094082832,
-0.05709206312894821,
-0.09923823177814484,
0.08330711722373962,
-0.014132224023342133,
0.18570992350578308,
0.06453393399715424,
0.11938197910785675,
0.06625542789697647,
0.07231566309928894,
0.00914198812097311,
0.05986470729112625,
-0.12240216881036758,
0.10753929615020752,
0.00589540833607316,
-0.015310468152165413,
0.17375604808330536,
-0.20516178011894226,
0.22953176498413086,
-0.046027809381484985,
-0.034304339438676834,
0.26303786039352417,
0.10652550309896469,
0.03220529109239578,
-0.2595303952693939,
0.17891688644886017,
0.04571960121393204,
-0.02868342027068138,
-0.1541057527065277,
0.12226289510726929,
-0.025695117190480232,
0.19237715005874634,
0.08759462833404541,
0.05449066683650017,
-0.05181407928466797,
0.43960487842559814,
0.07781761884689331,
0.15129700303077698,
0.11508635431528091,
0.20019757747650146,
-0.1549990177154541,
-0.10624808073043823,
-0.048853784799575806,
0.015662727877497673,
-0.12150726467370987,
0.17424705624580383,
-0.10268979519605637,
-0.08739424496889114,
-0.003221026621758938,
0.21544471383094788,
-0.05264078080654144,
-0.07986965775489807,
0.11043020337820053,
-0.03852105513215065,
0.19429120421409607,
0.0512663871049881,
-0.1632874310016632,
-0.18137092888355255,
-0.0397944413125515,
-0.17161838710308075,
0.3685332238674164,
-0.24422037601470947,
0.03324579820036888,
0.057847265154123306,
-0.0894942507147789,
0.0008107675821520388,
0.06759456545114517,
0.0768551230430603,
0.021825022995471954,
-0.162435382604599,
0.2775399088859558,
0.03743864595890045,
-0.08421599119901657,
-0.042364899069070816,
0.013090735301375389,
-0.1317482590675354,
-0.10795724391937256,
-0.1335023194551468,
-0.13037987053394318,
-0.06268181651830673,
0.08337237685918808,
0.11185535043478012,
0.05881815776228905,
0.20197388529777527,
0.05288024991750717,
-0.4228760302066803,
-0.25779470801353455,
-0.011080391705036163,
0.037571895867586136,
0.0059624481946229935,
0.03844553604722023,
0.17687927186489105,
-0.0757533609867096,
-0.12879106402397156,
-0.18547165393829346,
-0.15794186294078827,
0.07443730533123016,
-0.09728053212165833,
-0.23329350352287292,
-0.14065095782279968,
0.012523969635367393,
0.054058536887168884,
0.14297236502170563,
-0.051910098642110825,
-0.09457598626613617,
0.3511592447757721,
-0.16909639537334442,
0.010265633463859558,
0.07274413853883743,
0.21009331941604614,
0.08533751219511032,
-0.05965547263622284,
0.15422461926937103,
0.4063092768192291,
0.11904259771108627,
-0.13614244759082794,
-0.19246000051498413,
-0.1039845198392868,
0.09117923676967621,
-0.159320667386055,
0.15378834307193756,
-0.1059451550245285,
0.08679680526256561,
0.07801050692796707,
-0.16579096019268036,
0.002041183179244399,
0.06683384627103806,
0.01920776069164276,
0.06488557904958725,
-0.12236374616622925,
0.15808844566345215,
0.09913628548383713,
0.06283149123191833,
-0.0977785512804985,
-0.08574384450912476,
0.034084517508745193,
-0.050388019531965256,
0.07589266449213028,
-0.11495273560285568,
0.2060886174440384,
-0.08116184920072556,
0.09544891864061356,
0.034450192004442215,
-0.06446446478366852,
0.015516155399382114,
0.06572778522968292,
0.04858279228210449,
-0.1343303918838501,
0.10729563236236572,
-0.1858273446559906,
0.13151605427265167,
-0.09712493419647217,
0.031232303008437157,
0.23939231038093567,
0.1699230670928955,
-0.07131616026163101,
-0.1289878934621811,
0.13306249678134918,
0.005454403813928366,
-0.15775232017040253,
-0.05822310969233513,
0.06371264904737473,
-0.031768038868904114,
-0.23421019315719604,
0.13307490944862366,
-0.022292332723736763,
-0.04412245750427246,
0.22373877465724945,
0.08883823454380035,
0.055150408297777176,
-0.1355448067188263,
-0.006713449489325285,
0.044708605855703354,
-0.1401045024394989,
-0.21525637805461884,
0.309648334980011,
-0.053506039083004,
-0.046654824167490005,
0.0874420776963234,
0.008394727483391762,
-0.016459178179502487,
-0.11560587584972382,
0.11187931150197983,
-0.13224832713603973,
0.0679653063416481
] |
omim | https://www.omim.org/entry/252011 | rowjg6v | MITOCHONDRIAL COMPLEX II DEFICIENCY | C1855008 | 31,757 | mitochondrial complex ii deficiency. (600857.0001). Bourgeron et al. (1995) claimed that this was the first report of a nuclear gene mutation causing a mitochondrial respiratory chain deficiency in humans. In affected members of an Italian and Turkish family with mitochondrial complex II deficiency, Ghezzi et al. (2009) identified 2 different homozygous mutations in the SDHAF1 gene (612848.0001 and 612848.0002, respectively). Some of patients had been reported by Brockmann et al. (2002) and Bugiani et al. (2006). Associations Pending Confirmation
For discussion of a possible association between mitochondrial complex II deficiency and variation in the SDHB gene, see 185470.0020; for discussion of a possible association with variation in the SDHD gene, see 602690.0029.
INHERITANCE
- Autosomal recessive
GROWTH
Height
- Short stature
Other
- Poor growth
HEAD & NECK
Eyes
- Ptosis
- Ophthalmoplegia
- Pigment | [
-0.09028906375169754,
0.09418542683124542,
0.04183259978890419,
-0.250844269990921,
0.17108605802059174,
-0.008108842186629772,
0.08610305190086365,
-0.2438754439353943,
-0.16250352561473846,
0.072210893034935,
-0.025760101154446602,
0.06492279469966888,
0.16211579740047455,
0.0695667415857315,
-0.009018117561936378,
0.026919513940811157,
-0.04882841929793358,
-0.05676739662885666,
-0.05595473572611809,
0.010034979321062565,
-0.06362968683242798,
-0.07895916700363159,
0.04848460480570793,
0.16837438941001892,
-0.03397988900542259,
-0.20782198011875153,
-0.016701562330126762,
0.1367102712392807,
0.015432188287377357,
0.10565169155597687,
-0.013812006451189518,
-0.07864980399608612,
-0.07632076740264893,
-0.16494259238243103,
0.2604588270187378,
-0.12833811342716217,
-0.15810081362724304,
-0.1458846926689148,
0.0712621882557869,
-0.015926582738757133,
-0.05916346237063408,
-0.05543027073144913,
0.113203264772892,
-0.10786115378141403,
0.11995996534824371,
0.016907434910535812,
0.08908484876155853,
-0.03896643593907356,
0.07063058763742447,
0.15012037754058838,
-0.025310182943940163,
-0.18880663812160492,
0.028283478692173958,
-0.13572247326374054,
0.07612742483615875,
-0.12968531250953674,
-0.0676916241645813,
0.0989733561873436,
-0.18027380108833313,
-0.06773941963911057,
-0.0586741603910923,
0.1496477574110031,
-0.12021274864673615,
-0.18585820496082306,
0.20513296127319336,
-0.15873633325099945,
-0.1334686577320099,
0.09914971143007278,
0.15223385393619537,
0.12687422335147858,
0.22579289972782135,
-0.16080720722675323,
-0.03481893241405487,
0.18892201781272888,
-0.08378211408853531,
0.17693378031253815,
0.15218907594680786,
-0.11288914084434509,
0.2910437285900116,
-0.14231863617897034,
0.011809167452156544,
0.12287688255310059,
0.033236775547266006,
-0.06649918854236603,
0.11684437841176987,
0.2585557699203491,
0.06090623512864113,
0.07728475332260132,
-0.013081898912787437,
0.10646483302116394,
0.0778818130493164,
-0.1723562777042389,
0.03632591292262077,
-0.20902734994888306,
0.2624611258506775,
-0.10521489381790161,
0.11385469138622284,
-0.01804542727768421,
0.05216939002275467,
0.23997017741203308,
0.24288024008274078,
0.016805564984679222,
0.008159725926816463,
-0.1784645915031433,
-0.13332021236419678,
-0.05742431804537773,
-0.09125436097383499,
0.01795962266623974,
-0.13167226314544678,
0.10610875487327576,
-0.0391952209174633,
-0.12779390811920166,
-0.269278883934021,
0.02395552396774292,
-0.0397559218108654,
0.0667496919631958,
0.08547211438417435,
0.16333231329917908,
0.07457475364208221,
-0.05204296484589577,
0.09336287528276443,
0.05898632854223251,
0.048800885677337646,
-0.017262006178498268,
-0.028181245550513268,
0.25401437282562256,
0.10093802958726883,
0.056182727217674255,
0.38036391139030457,
-0.08770149201154709,
-0.009695073589682579,
0.04105030745267868,
-0.15625877678394318,
-0.013499430380761623,
0.07749339938163757,
-0.06328164041042328,
-0.10269160568714142,
-0.24462755024433136,
-0.14604797959327698,
0.07356627285480499,
-0.025761131197214127,
0.012052000500261784,
0.14189772307872772,
0.20230399072170258,
0.05725506693124771,
-0.02084840089082718,
0.23950788378715515,
0.09829190373420715,
0.024520162492990494,
0.013322536833584309,
0.33895525336265564,
-0.12103991210460663,
0.24218380451202393,
-0.18094390630722046,
-0.040363114327192307,
-0.09579744935035706,
-0.02683078870177269,
0.01238997932523489,
-0.06973825395107269,
-0.02881796285510063,
0.05603582412004471,
-0.02511289156973362,
-0.0669725313782692,
-0.026639772579073906,
-0.053835950791835785,
-0.10514085739850998,
-0.2357863485813141,
0.15490032732486725,
-0.11011290550231934,
-0.024389047175645828,
-0.10909564048051834,
0.12943653762340546,
0.03635605424642563,
0.002332877367734909,
0.2526291608810425,
0.15095216035842896,
-0.04549720510840416,
-0.18910787999629974,
0.06812643259763718,
0.057160504162311554,
-0.05702757090330124,
-0.1464080512523651,
-0.07975389808416367,
-0.19745197892189026,
0.036228012293577194,
-0.05243248492479324,
0.13751542568206787,
0.19872595369815826,
-0.1730552464723587,
0.0539146326482296,
0.07182679325342178,
0.06389199942350388,
0.06786538660526276,
-0.03442767262458801,
-0.1565524786710739,
-0.020376110449433327,
-0.020323745906352997,
-0.18846866488456726,
-0.14411884546279907,
-0.05941227450966835,
0.3449839949607849,
0.05357156693935394,
0.14153096079826355,
0.0642993301153183,
-0.07390177249908447,
-0.1368710845708847,
0.07532390207052231,
-0.11456435173749924,
0.09912499040365219,
0.06867431104183197,
-0.006443472113460302,
-0.0356689989566803,
-0.18786443769931793,
0.14971572160720825,
-0.031163861975073814,
-0.21620452404022217,
0.1414264440536499,
-0.01900157704949379,
0.15316571295261383,
-0.03615165501832962,
0.11746078729629517,
0.04852217063307762,
-0.1761651337146759,
-0.21498161554336548,
-0.2442469745874405,
0.166314035654068,
-0.032714493572711945,
-0.053356464952230453,
0.11555307358503342,
0.07274097949266434,
0.05097359046339989,
0.09399455040693283,
-0.08872801065444946,
-0.022037837654352188,
0.02969682775437832,
-0.12554457783699036,
-0.13834042847156525,
0.1430211216211319,
0.08043230324983597,
0.21936392784118652,
-0.22735874354839325,
-0.012488040141761303,
-0.044584181159734726,
0.17828650772571564,
0.026920288801193237,
0.08227739483118057,
-0.0437002070248127,
0.05613524466753006,
-0.1207035556435585,
0.024031247943639755,
-0.01965736597776413,
-0.007834488525986671,
0.07385262101888657,
-0.029487060382962227,
-0.3519226312637329,
-0.07040689140558243,
0.0383320115506649,
-0.06078964099287987,
0.03979101777076721,
0.04321505129337311,
0.1354377567768097,
0.10224559903144836,
0.062221016734838486,
0.02589726261794567,
-0.18040646612644196,
-0.16434714198112488,
-0.21843382716178894,
-0.018263982608914375,
0.0675208568572998,
-0.34100255370140076,
-0.08998414129018784,
0.14669948816299438,
0.068125881254673,
0.13482989370822906,
-0.019218316301703453,
-0.13375185430049896,
-0.0741356685757637,
-0.006293484941124916,
0.14571142196655273,
0.05480796843767166,
-0.18036656081676483,
-0.05451663210988045,
-0.27244147658348083,
-0.01818821020424366,
0.1781863123178482,
-0.05277806147933006,
0.12530992925167084,
0.044027358293533325,
0.024444662034511566,
0.037384141236543655,
0.03550315648317337,
0.11279105395078659,
-0.17793098092079163,
0.017085758969187737,
-0.03432432562112808,
-0.13587728142738342,
0.17065779864788055,
-0.09115418046712875,
0.1689770370721817,
0.01689773239195347,
0.12123130261898041,
0.09064506739377975,
0.08257299661636353,
0.030337810516357422,
-0.1955619752407074,
0.1796390861272812,
0.0262554120272398,
0.19896070659160614,
0.005795905366539955,
0.1416933238506317,
-0.21645784378051758,
-0.11524631828069687,
-0.0829300507903099,
0.06383756548166275,
-0.03997690603137016,
-0.17866243422031403,
-0.2177966684103012,
0.027130383998155594,
-0.0057472228072583675,
0.17702287435531616,
0.014244185760617256,
0.15305891633033752,
-0.09157191962003708,
0.20119424164295197,
-0.10430844128131866,
0.07739430665969849,
0.038899414241313934,
0.24327883124351501,
-0.19398732483386993,
0.17892834544181824,
0.1593601256608963,
0.19655242562294006,
-0.16523787379264832,
-0.04869503155350685,
-0.029938654974102974,
0.07007947564125061,
0.152144193649292,
-0.12959778308868408,
-0.14481955766677856,
0.013555084355175495,
0.19811442494392395,
-0.30018988251686096,
-0.10198408365249634,
-0.15345020592212677,
-0.21888019144535065,
0.05909908562898636,
0.04608878865838051,
0.0791226327419281,
0.021388297900557518,
-0.09775489568710327,
-0.13325588405132294,
0.06984233856201172,
-0.11120285093784332,
-0.0737496167421341,
0.056451328098773956,
-0.13825668394565582,
-0.051669422537088394,
0.17299988865852356,
0.1847156286239624,
-0.04758819192647934,
-0.03334672749042511,
-0.06048128381371498,
0.07696127891540527,
-0.09419576823711395,
-0.05261998996138573,
0.004419786389917135,
0.05417715758085251,
0.07935357838869095,
0.03168630972504616,
-0.0006018868880346417,
0.18178702890872955,
-0.014279416762292385,
0.0722118392586708,
-0.060485586524009705,
0.03688687086105347,
0.08897528797388077,
-0.1350674331188202,
0.058448560535907745,
0.06131148338317871,
-0.013451926410198212,
-0.1601915955543518,
0.10067258775234222,
0.12767179310321808,
-0.04290444031357765,
0.04394116252660751,
0.20064181089401245,
-0.03650357574224472,
0.044482991099357605,
-0.003537094220519066,
-0.170939639210701,
-0.05335834249854088,
0.21133676171302795,
0.09345444291830063,
0.07779008150100708,
0.011905830353498459,
0.17906205356121063,
-0.13750414550304413,
0.06689276546239853,
-0.24319452047348022,
-0.07884565740823746,
-0.08363233506679535,
-0.0473082959651947,
0.20751824975013733,
0.28358808159828186,
0.011975977569818497,
-0.07488109916448593,
0.1588141918182373,
0.25691255927085876,
-0.25227120518684387,
0.057883601635694504,
-0.09693732112646103,
0.15989898145198822,
0.0688772052526474,
-0.11003980040550232,
-0.11720853298902512,
0.03724491223692894,
0.07807879894971848,
-0.03804852068424225,
-0.07137127220630646,
-0.03887249529361725,
-0.18119633197784424,
-0.25199151039123535,
0.23523454368114471,
-0.06968612968921661,
-0.08937535434961319,
-0.10361219197511673,
0.14693692326545715,
0.07587136328220367,
0.09243752807378769,
0.08189172297716141,
0.0015733595937490463,
-0.09054957330226898,
-0.09537018090486526,
0.1959170699119568,
0.08424840122461319,
0.30214184522628784,
0.14399293065071106,
-0.05180046707391739,
0.15560707449913025,
-0.02688203938305378,
0.03383226320147514,
0.15548285841941833,
0.016262995079159737,
-0.20880116522312164,
-0.07309793680906296,
0.13897395133972168,
0.09030890464782715,
0.009303214959800243,
-0.13593944907188416,
0.03380397707223892,
-0.054797567427158356,
-0.08818495273590088,
-0.0794403925538063,
-0.07854609936475754,
0.016160650178790092,
0.20133376121520996,
0.17169883847236633,
0.02423475868999958,
-0.06415487825870514,
-0.15771730244159698,
0.20911751687526703,
-0.012986431829631329,
0.23384733498096466,
-0.10511164367198944,
0.13199326395988464,
0.15320870280265808,
-0.12963996827602386,
-0.10804435610771179,
0.19312046468257904,
-0.011768842115998268,
0.1606431007385254,
0.13793480396270752,
-0.08510790765285492,
-0.10110383480787277,
-0.21863919496536255,
0.022245850414037704,
0.10039292275905609,
0.018912846222519875,
-0.0005566955078393221,
0.06426951289176941,
0.06407491862773895,
-0.06455056369304657,
-0.21524269878864288,
0.1690235733985901,
0.001754137803800404,
0.03823411837220192,
0.005568134132772684,
-0.15932410955429077,
0.19368040561676025,
0.02187083661556244,
-0.007708259392529726,
0.059271473437547684,
0.005173764657229185,
0.08396144956350327,
-0.16913168132305145,
-0.10294894874095917,
0.09660013020038605,
0.026331325992941856,
-0.10912461578845978,
-0.16716916859149933,
0.07694811373949051,
-0.011195236817002296,
-0.08360955864191055,
0.2388194054365158,
-0.10153127461671829,
-0.02672235295176506,
-0.15499982237815857,
-0.21193958818912506,
-0.01740073598921299,
0.16465125977993011,
0.2346552014350891,
-0.07022428512573242,
0.05883082374930382,
-0.07009416818618774,
0.03883099928498268,
-0.2710023522377014,
0.25207412242889404,
0.09453372657299042,
0.13658788800239563,
0.0021774498745799065,
-0.05436856299638748,
-0.2876930236816406,
0.43461722135543823,
0.08545403927564621,
0.001109260250814259,
-0.01760753057897091,
0.14597760140895844,
0.10082032531499863,
0.0973949134349823,
-0.05339646711945534,
0.08537722378969193,
-0.0023945625871419907,
-0.3243715763092041,
0.18089550733566284,
0.09292872995138168,
-0.11344613134860992,
0.040373507887125015,
-0.2345578670501709,
-0.058300506323575974,
-0.022379983216524124,
0.07342181354761124,
0.09113799780607224,
-0.03522471338510513,
-0.13077162206172943,
0.043964989483356476,
-0.16006742417812347,
-0.08001618832349777,
-0.10176097601652145,
-0.08273299038410187,
0.1002272516489029,
-0.1234666183590889,
0.09837862104177475,
0.2062981277704239,
0.2145625799894333,
-0.1615598499774933,
-0.24004492163658142,
0.021804939955472946,
-0.056459203362464905,
-0.003152823308482766,
-0.09443657845258713,
0.0041569070890545845,
0.06256135553121567,
-0.029258674010634422,
-0.12361928075551987,
-0.15217970311641693,
0.05733892694115639,
0.2844596207141876,
0.05002828314900398,
-0.004021346103399992,
-0.2853788435459137,
0.07063715159893036,
-0.06837201863527298,
-0.1026330441236496,
0.0299320537596941,
-0.0158021729439497,
-0.01315043494105339,
-0.1246853768825531,
-0.13332721590995789,
-0.12115765362977982,
0.09427744150161743,
-0.03288168087601662,
0.04795714095234871,
-0.14593447744846344,
-0.20369720458984375,
0.0790625661611557,
0.03053763508796692,
0.06166442483663559,
0.004270870238542557,
0.18598438799381256,
0.06882845610380173,
0.15434646606445312,
0.1170370951294899,
0.022371025756001472,
-0.02122333087027073,
0.10443967580795288,
-0.12010800093412399,
0.12450514733791351,
-0.10185222327709198,
-0.01091387402266264,
0.1362224817276001,
0.07655089348554611,
0.11321302503347397,
0.09234125167131424,
0.0006770273903384805,
0.09668252617120743,
0.0492369681596756,
0.04107261821627617,
-0.05244876444339752,
0.14425167441368103,
-0.0019558179192245007,
-0.11076726019382477,
-0.10738059133291245,
0.20852044224739075,
0.05423707142472267,
0.030657542869448662,
0.07576167583465576,
0.02257469668984413,
-0.004082467872649431,
0.15329082310199738,
-0.07512124627828598,
0.26075196266174316,
0.020694922655820847,
0.13740453124046326,
-0.03265126794576645,
-0.197854682803154,
0.10120153427124023,
0.04614891856908798,
-0.04326371103525162,
0.08880618214607239,
-0.13323329389095306,
0.023924481123685837,
-0.05276909098029137,
0.13065938651561737,
-0.14302054047584534,
-0.2593074142932892,
-0.029020095244050026,
0.08130186796188354,
0.08919844776391983,
0.025696871802210808,
-0.06662606447935104,
0.03291068598628044,
0.13918247818946838,
-0.11389565467834473,
0.25628525018692017,
-0.2358950972557068,
0.16848978400230408,
0.055488470941782,
-0.16047199070453644,
-0.08730615675449371,
-0.10460081696510315,
0.02771621383726597,
-0.04095214977860451,
-0.06562425196170807,
0.20327720046043396,
-0.07778169959783554,
-0.07974975556135178,
-0.020883779972791672,
-0.10080841183662415,
0.1270897537469864,
-0.08212212473154068,
-0.10547935962677002,
0.07529737800359726,
-0.08008135110139847,
0.14598213136196136,
-0.13346067070960999,
-0.0555659718811512,
0.27994781732559204,
0.023976227268576622,
-0.11608103662729263,
-0.1612861454486847,
-0.12445834279060364,
0.1441570222377777,
-0.09308448433876038,
0.11127227544784546,
0.16018056869506836,
0.07410252094268799,
-0.04645067825913429,
-0.08624541759490967,
-0.15008988976478577,
0.15578322112560272,
-0.15267805755138397,
-0.24283546209335327,
-0.07704493403434753,
-0.0786420926451683,
-0.032008975744247437,
0.06550704687833786,
-0.10585767775774002,
-0.08607340604066849,
0.08930183947086334,
-0.11725793033838272,
0.04562637209892273,
-0.014402629807591438,
0.21474309265613556,
0.0391654409468174,
-0.03936263546347618,
0.019485345110297203,
0.2935267984867096,
0.09107331186532974,
-0.20015087723731995,
-0.0692770779132843,
-0.18206582963466644,
0.12053635716438293,
-0.2799660861492157,
0.012101180851459503,
-0.031832244247198105,
0.19096291065216064,
0.11916729807853699,
-0.1989906281232834,
0.04922772943973541,
-0.04602833837270737,
-0.04779249429702759,
0.05381786450743675,
-0.08156798779964447,
0.2438795119524002,
0.21380488574504852,
0.13059064745903015,
-0.21917413175106049,
0.1597798466682434,
-0.03775208070874214,
0.017713334411382675,
0.08094975352287292,
-0.01974976621568203,
0.05094215273857117,
-0.094630166888237,
0.16115747392177582,
0.07580478489398956,
0.1870151311159134,
0.10526108741760254,
0.15265637636184692,
0.012153351679444313,
-0.046017635613679886,
0.11469805985689163,
-0.05409496650099754,
-0.060522399842739105,
0.03965019807219505,
0.039390530437231064,
0.02199534885585308,
0.06408768147230148,
0.1211724504828453,
-0.01976865902543068,
-0.043172672390937805,
0.08134116232395172,
0.01487570721656084,
-0.026050392538309097,
0.07963431626558304,
0.07178303599357605,
-0.059376634657382965,
0.09710779041051865,
0.07680536806583405,
0.018304571509361267,
0.14304806292057037,
0.29226499795913696,
0.20214244723320007,
-0.17929841578006744,
-0.10216818004846573,
-0.025493966415524483,
-0.13556315004825592,
-0.28710711002349854,
0.22814592719078064,
-0.11056002974510193,
-0.16161003708839417,
-0.12411511689424515,
-0.12843964993953705,
0.012283850461244583,
0.0013675879454240203,
0.13876943290233612,
0.023019684478640556,
0.13077814877033234
] |
omim | https://www.omim.org/entry/252011 | rowjg6v | MITOCHONDRIAL COMPLEX II DEFICIENCY | C1855008 | 31,757 | mitochondrial complex ii deficiency. been reported by Brockmann et al. (2002) and Bugiani et al. (2006). Associations Pending Confirmation
For discussion of a possible association between mitochondrial complex II deficiency and variation in the SDHB gene, see 185470.0020; for discussion of a possible association with variation in the SDHD gene, see 602690.0029.
INHERITANCE
- Autosomal recessive
GROWTH
Height
- Short stature
Other
- Poor growth
HEAD & NECK
Eyes
- Ptosis
- Ophthalmoplegia
- Pigmentary retinopathy
- Optic atrophy
- Nystagmus
- Impaired vision
CARDIOVASCULAR
Heart
- Hypertrophic cardiomyopathy
- Dilated cardiomyopathy
- Left ventricular noncompaction
SKELETAL
- Joint contractures
MUSCLE, SOFT TISSUES
- Hypotonia, neonatal
- Muscle weakness
- Exercise intolerance
- Ragged red fibers seen on muscle biopsy
- Abnormal mitochondria with paracrystalline inclusions seen on muscle biopsy
- Accumulated lipid droplets seen on muscle biopsy
NEUROLOGIC
Central Nervous System
- Psychomotor regression in infants
- Spasticity
- Hyperreflexia
- Extensor plantar responses
- Ataxia | [
0.08698610961437225,
-0.008661780506372452,
0.060948822647333145,
-0.23712894320487976,
0.11638914793729782,
-0.1496724784374237,
-0.14309272170066833,
-0.2371535301208496,
-0.1791062355041504,
0.07911816239356995,
0.19651634991168976,
-0.014805339276790619,
0.13738706707954407,
0.13152265548706055,
-0.041265878826379776,
0.05187705531716347,
-0.04399819299578667,
-0.018815189599990845,
-0.11970919370651245,
-0.15040427446365356,
-0.1355147808790207,
-0.17110276222229004,
-0.01276491954922676,
0.17179344594478607,
-0.09950653463602066,
-0.07576749473810196,
0.09729428589344025,
0.08498493582010269,
-0.07423461973667145,
0.1320153921842575,
-0.06085608899593353,
-0.012124141678214073,
0.25674620270729065,
-0.034129805862903595,
0.06345804035663605,
-0.20248548686504364,
-0.04721847176551819,
-0.26797327399253845,
0.14675982296466827,
-0.08730649203062057,
-0.10866184532642365,
-0.019343530759215355,
0.14053206145763397,
-0.0523202009499073,
0.1765814572572708,
-0.08365876972675323,
-0.017120812088251114,
-0.050560321658849716,
0.1229127049446106,
0.08229097723960876,
0.08848491311073303,
-0.1844484508037567,
0.004568328615278006,
0.0011377852642908692,
0.08771473914384842,
-0.049409329891204834,
-0.12598799169063568,
0.11403089016675949,
-0.17436069250106812,
0.06984315067529678,
0.13922391831874847,
0.16302303969860077,
-0.1102822870016098,
-0.1509561836719513,
0.2812190055847168,
-0.23782028257846832,
0.07850971072912216,
0.06183742731809616,
0.22504515945911407,
0.12405215948820114,
0.20147587358951569,
-0.3099302649497986,
-0.06438753008842468,
0.3610970079898834,
-0.12310659140348434,
0.024235211312770844,
0.11961941421031952,
-0.143220454454422,
0.09684334695339203,
-0.18514499068260193,
-0.03379034623503685,
-0.04547324404120445,
-0.024203887209296227,
-0.011505244299769402,
0.024058012291789055,
0.0988994687795639,
0.05057467147707939,
-0.014623582363128662,
-0.05685918778181076,
-0.023934094235301018,
0.199921652674675,
-0.18217691779136658,
0.020416049286723137,
-0.059782709926366806,
0.10990598797798157,
-0.12878185510635376,
0.11243738979101181,
-0.08441922813653946,
0.12376023828983307,
0.09245690703392029,
0.2338476926088333,
0.14410269260406494,
-0.2043522149324417,
-0.20317193865776062,
-0.18147796392440796,
0.03689510375261307,
-0.21043062210083008,
0.020545149222016335,
-0.17890870571136475,
0.13465175032615662,
-0.04615819826722145,
-0.08407871425151825,
-0.0713047981262207,
0.025851929560303688,
-0.1372813731431961,
0.15092498064041138,
0.04790870472788811,
0.24256093800067902,
0.1279604285955429,
0.08627121150493622,
0.1374523788690567,
0.031072260811924934,
0.12215425819158554,
0.050822943449020386,
0.030234644189476967,
0.07421630620956421,
0.08997199684381485,
0.026996588334441185,
0.29938259720802307,
-0.13049206137657166,
-0.030178824439644814,
0.018176443874835968,
-0.22884616255760193,
0.1562497317790985,
0.14305506646633148,
-0.07064598053693771,
-0.16351233422756195,
-0.28253769874572754,
0.009259501472115517,
-0.028801528736948967,
-0.0439729243516922,
-0.08564483374357224,
0.3054029047489166,
0.22225132584571838,
-0.01333585474640131,
-0.1521480530500412,
0.1764739751815796,
0.039476677775382996,
0.16831563413143158,
0.0598764568567276,
0.26656585931777954,
-0.2435920089483261,
0.10133568197488785,
-0.09134086966514587,
-0.0384947806596756,
0.09697932749986649,
-0.061063554137945175,
-0.0952484980225563,
-0.17723584175109863,
0.14510519802570343,
0.05308181047439575,
-0.041299883276224136,
-0.08113757520914078,
-0.06062959134578705,
-0.23364000022411346,
-0.020338233560323715,
-0.34497883915901184,
0.0531245581805706,
0.15371589362621307,
-0.08943524211645126,
-0.18557144701480865,
0.1436777561903,
-0.12146704643964767,
-0.1451905369758606,
0.12830331921577454,
0.20945270359516144,
0.10574771463871002,
-0.19832682609558105,
-0.10620871931314468,
-0.0742470994591713,
0.008835465647280216,
0.04232042282819748,
-0.2321411520242691,
-0.05422218516469002,
0.21048645675182343,
-0.25757554173469543,
0.043578434735536575,
0.10023895651102066,
-0.3817763030529022,
-0.01480131782591343,
0.019545365124940872,
0.13454626500606537,
0.14645037055015564,
0.0011051282053813338,
-0.06296003609895706,
-0.2324003279209137,
-0.08335067331790924,
-0.2115459144115448,
-0.016362285241484642,
0.03785378113389015,
0.31411629915237427,
-0.04857078567147255,
0.09399224072694778,
0.07953978329896927,
-0.08116977661848068,
0.05608025938272476,
0.16791078448295593,
-0.18596898019313812,
0.07961537688970566,
0.13300268352031708,
-0.08127400279045105,
-0.11568253487348557,
-0.04628412052989006,
0.16416136920452118,
-0.06870732456445694,
0.03136809915304184,
-0.0021155844442546368,
0.16218914091587067,
0.09676556289196014,
0.1202746257185936,
0.10999594628810883,
0.11561516672372818,
-0.02891235239803791,
-0.40800926089286804,
-0.2518954873085022,
0.14816676080226898,
-0.20700973272323608,
-0.0048116580583155155,
0.08750827610492706,
-0.19754156470298767,
0.05619218200445175,
-0.026500960811972618,
-0.21874897181987762,
-0.12239164859056473,
0.03933219611644745,
-0.18269771337509155,
-0.07277149707078934,
0.17958150804042816,
0.16596576571464539,
0.06779328733682632,
-0.29974859952926636,
-0.009933913126587868,
-0.07101966440677643,
0.18814319372177124,
-0.0314149409532547,
-0.04319388046860695,
-0.10087613761425018,
0.3067845404148102,
-0.050353195518255234,
0.2557445168495178,
-0.09355901926755905,
0.09925349056720734,
0.08774901926517487,
0.0476808026432991,
-0.3421075642108917,
-0.15851138532161713,
-0.024283645674586296,
-0.04461491480469704,
0.12213394045829773,
0.10235846787691116,
0.13470673561096191,
0.01949746161699295,
0.00508413091301918,
-0.11255879700183868,
-0.18859368562698364,
-0.18276503682136536,
-0.1361021250486374,
0.053435102105140686,
0.05961805582046509,
-0.27804121375083923,
-0.16694290935993195,
0.1934741735458374,
0.3048529028892517,
0.08333172649145126,
-0.06101720407605171,
-0.14249424636363983,
0.09285836666822433,
0.18130120635032654,
0.08195753395557404,
0.025854958221316338,
-0.24972519278526306,
-0.10065045207738876,
-0.31851211190223694,
0.07952506840229034,
0.2738569974899292,
-0.012240806594491005,
0.18874725699424744,
0.11400346457958221,
0.01836738921701908,
-0.03533142805099487,
0.00610159570351243,
0.06966933608055115,
-0.2753252685070038,
0.027975698933005333,
-0.054999787360429764,
-0.18877464532852173,
0.21357443928718567,
0.004857166670262814,
0.17682667076587677,
0.00566154345870018,
0.01940876618027687,
0.20890584588050842,
0.0731506422162056,
0.17409397661685944,
-0.23853382468223572,
0.2204325646162033,
0.007512577343732119,
0.12206166237592697,
0.2051391452550888,
-0.021522583439946175,
-0.2556174695491791,
-0.004082744941115379,
-0.18979527056217194,
-0.12192117422819138,
-0.08486306667327881,
-0.020677097141742706,
-0.2124422937631607,
0.07530918717384338,
0.05702557414770126,
0.25271347165107727,
0.05818181857466698,
0.18545638024806976,
-0.0202961303293705,
0.32122308015823364,
-0.10467691719532013,
0.061490874737501144,
0.0074630798771977425,
0.36944136023521423,
-0.10560863465070724,
0.0522816926240921,
0.119215227663517,
0.19358614087104797,
-0.14909853041172028,
-0.11211169511079788,
-0.009946311824023724,
0.07447578758001328,
0.21962420642375946,
-0.05257036164402962,
-0.12328328937292099,
-0.08337801694869995,
0.08187409490346909,
-0.45992687344551086,
-0.06616390496492386,
-0.04666192829608917,
-0.1097731739282608,
0.032311245799064636,
0.18575453758239746,
0.0363907627761364,
0.15798036754131317,
-0.09481634199619293,
-0.21336150169372559,
0.15431301295757294,
-0.21569859981536865,
-0.19877009093761444,
-0.04777345806360245,
-0.19701582193374634,
-0.06060989573597908,
0.2023337185382843,
0.14037460088729858,
0.11751777678728104,
-0.04073131084442139,
-0.08197256177663803,
0.11205883324146271,
0.006936688907444477,
-0.11988535523414612,
-0.14170776307582855,
-0.053322162479162216,
0.020517580211162567,
0.22759176790714264,
0.04429720342159271,
0.24811910092830658,
-0.1321045160293579,
0.04575290530920029,
-0.003643218195065856,
-0.1127902939915657,
0.18496377766132355,
-0.07393360137939453,
-0.034716784954071045,
0.10755605250597,
0.092997707426548,
-0.07430580258369446,
0.19088290631771088,
-0.025579527020454407,
0.2352340966463089,
-0.023282956331968307,
0.11833253502845764,
-0.12082485854625702,
0.2086893767118454,
0.1498020738363266,
-0.23861445486545563,
0.06500720232725143,
0.05283023789525032,
0.09895308315753937,
0.216672882437706,
0.19297678768634796,
0.21848197281360626,
-0.0426219217479229,
0.14681509137153625,
-0.18169711530208588,
-0.08321499079465866,
-0.14074364304542542,
-0.09300914406776428,
0.2100658416748047,
0.23161767423152924,
0.03827808052301407,
-0.16813181340694427,
0.10264969617128372,
0.24858418107032776,
-0.41977858543395996,
-0.035680703818798065,
-0.15281172096729279,
0.02773311361670494,
-0.15025150775909424,
-0.09436994791030884,
-0.17640569806098938,
0.03335416316986084,
0.11668714135885239,
0.06912997364997864,
-0.0829407274723053,
-0.011693946085870266,
-0.17689542472362518,
-0.1567487269639969,
0.19240261614322662,
-0.05213332548737526,
-0.1477055847644806,
-0.11389949917793274,
0.03394247218966484,
0.06542567908763885,
0.1659172624349594,
0.017592554911971092,
0.024071533232927322,
0.13106004893779755,
-0.10120897740125656,
0.24090181291103363,
0.12966465950012207,
0.2777562141418457,
0.11484329402446747,
-0.13416026532649994,
0.012623905204236507,
-0.14474332332611084,
0.07763039320707321,
0.13207775354385376,
0.014206649735569954,
-0.13663311302661896,
-0.1577197164297104,
0.0583152212202549,
0.15385636687278748,
0.20964664220809937,
-0.03792303800582886,
-0.045730795711278915,
-0.10679671913385391,
-0.20357230305671692,
0.05997674912214279,
-0.055968061089515686,
-0.0329730324447155,
0.19372831284999847,
0.16685429215431213,
-0.0017834260361269116,
-0.1230413168668747,
-0.2128293812274933,
0.10656654089689255,
-0.01696230098605156,
0.3104346990585327,
-0.20988783240318298,
0.13022229075431824,
0.08225107938051224,
-0.15595434606075287,
-0.3041774332523346,
0.12243589013814926,
-0.09625077247619629,
0.24229106307029724,
0.18378350138664246,
-0.01119590736925602,
0.22483496367931366,
-0.12433113157749176,
0.018300391733646393,
-0.05765753239393234,
-0.021212514489889145,
0.1813400834798813,
-0.043430015444755554,
-0.018898513168096542,
-0.091283418238163,
-0.06060115993022919,
-0.07616983354091644,
0.0020713144913315773,
-0.003214531810954213,
-0.08661585301160812,
-0.007956516928970814,
0.2132387012243271,
0.08227711915969849,
0.05958416685461998,
-0.0836249515414238,
0.04829922318458557,
0.21614786982536316,
-0.12062393128871918,
-0.24529166519641876,
0.06492674350738525,
0.08824389427900314,
-0.1688440591096878,
-0.1714409738779068,
0.23728999495506287,
-0.19769740104675293,
-0.31169816851615906,
0.10187654197216034,
-0.1925463080406189,
-0.1386841982603073,
-0.20090295374393463,
-0.26667100191116333,
-0.02874475158751011,
0.19773544371128082,
0.21063783764839172,
-0.0185781829059124,
0.16653530299663544,
-0.18372176587581635,
0.1142909824848175,
-0.3598213195800781,
0.2618884742259979,
0.23636925220489502,
0.04602205380797386,
-0.08929555118083954,
-0.13184994459152222,
-0.2588843107223511,
0.2425653487443924,
0.09293415397405624,
0.10308530926704407,
0.02348957397043705,
-0.0034038368612527847,
0.21141652762889862,
0.16172030568122864,
-0.03669758886098862,
-0.10794882476329803,
0.1098272055387497,
-0.30963805317878723,
0.04936012998223305,
0.08814278990030289,
-0.01683063618838787,
0.05754699930548668,
-0.10874549299478531,
0.20920732617378235,
0.045092303305864334,
0.0398293100297451,
0.12063676118850708,
0.03511090204119682,
-0.05837342515587807,
0.11272811144590378,
-0.07632914930582047,
-0.04862155765295029,
0.04686012119054794,
-0.06844291090965271,
0.16084037721157074,
-0.08052068203687668,
0.059716615825891495,
0.08601972460746765,
0.15912166237831116,
-0.22109174728393555,
-0.36602768301963806,
0.1031595915555954,
-0.11228473484516144,
-0.19469811022281647,
-0.0771845281124115,
-0.13199366629123688,
-0.0035300017334520817,
-0.07040053606033325,
0.1641579121351242,
0.07797790318727493,
-0.016066277399659157,
0.12829452753067017,
0.15147359669208527,
-0.012062574736773968,
-0.23980140686035156,
0.22424006462097168,
-0.01299519557505846,
0.06828375160694122,
-0.12652598321437836,
-0.04334922879934311,
0.11755119264125824,
-0.20505481958389282,
-0.055330559611320496,
-0.08423354476690292,
-0.02587839774787426,
-0.19529129564762115,
0.048406537622213364,
-0.1362517774105072,
-0.2852492332458496,
0.06692676991224289,
0.061686575412750244,
-0.06365025788545609,
0.00389049737714231,
0.23795725405216217,
0.07477537542581558,
0.19538481533527374,
0.1309281289577484,
-0.07684389501810074,
-0.046371184289455414,
0.10043170303106308,
-0.20454546809196472,
0.1030014306306839,
-0.093277208507061,
0.046856243163347244,
0.1859142929315567,
0.018521899357438087,
0.33351370692253113,
0.1216876432299614,
-0.0025303983129560947,
-0.03213842958211899,
0.12425164133310318,
0.08663781732320786,
-0.08648733794689178,
0.19031672179698944,
-0.012258579954504967,
0.010382060892879963,
-0.17841972410678864,
0.1894085705280304,
0.022311244159936905,
0.13503475487232208,
0.00939686968922615,
0.1727478951215744,
0.03998711705207825,
0.3255845904350281,
-0.041580941528081894,
0.32474610209465027,
-0.06731074303388596,
0.21331408619880676,
-0.1651121973991394,
-0.24627165496349335,
0.13928104937076569,
0.10630829632282257,
-0.1499384343624115,
-0.008186104707419872,
-0.08973236382007599,
-0.035440005362033844,
0.14487794041633606,
0.025154298171401024,
0.027829529717564583,
-0.3723970353603363,
0.0740228220820427,
0.15641847252845764,
-0.0881602093577385,
-0.090470090508461,
-0.006562221795320511,
-0.040283601731061935,
0.15760309994220734,
-0.15122844278812408,
0.2537308931350708,
-0.23155446350574493,
0.12655270099639893,
0.015596405602991581,
-0.2403830885887146,
-0.15674053132534027,
-0.09095178544521332,
0.17539763450622559,
-0.1527012288570404,
-0.35604873299598694,
0.22481530904769897,
0.15705621242523193,
-0.10566412657499313,
0.039799656718969345,
-0.07454220950603485,
0.058215007185935974,
0.10121318697929382,
-0.16589437425136566,
0.2168092280626297,
0.10371045768260956,
0.21367737650871277,
-0.13985106348991394,
-0.06022638827562332,
0.03767218440771103,
0.14267267286777496,
-0.17936740815639496,
-0.06976636499166489,
-0.22451531887054443,
0.2168017029762268,
-0.07373867928981781,
0.19647932052612305,
0.011283219791948795,
0.022845005616545677,
-0.16589994728565216,
0.0027741482481360435,
0.07616051286458969,
0.33275243639945984,
0.07053513079881668,
-0.2971651554107666,
-0.06545455753803253,
-0.006695634685456753,
0.12326496094465256,
0.1744956076145172,
0.03649233281612396,
0.08312356472015381,
0.13442717492580414,
-0.02680256776511669,
0.1665341854095459,
0.051493365317583084,
0.10574787855148315,
-0.04761489853262901,
-0.05029909312725067,
-0.1771322339773178,
0.34823736548423767,
-0.031009269878268242,
-0.17577433586120605,
-0.08680171519517899,
-0.048655103892087936,
0.17176665365695953,
-0.1376727670431137,
0.05821450427174568,
-0.1579717993736267,
-0.01153952069580555,
0.09435068070888519,
-0.28818121552467346,
-0.12046270817518234,
0.032579876482486725,
-0.03461388126015663,
0.07071848958730698,
-0.11266779154539108,
0.255460262298584,
0.07046671956777573,
0.0886930525302887,
-0.08620115369558334,
0.18110616505146027,
-0.18058280646800995,
-0.013270746916532516,
-0.05932348221540451,
0.06625531613826752,
-0.06802701950073242,
-0.014461093582212925,
0.12618696689605713,
0.13535358011722565,
0.244365856051445,
-0.06732092052698135,
0.20474174618721008,
0.08458255231380463,
0.009394234977662563,
0.09089109301567078,
-0.11795251071453094,
-0.17478501796722412,
-0.02353384718298912,
-0.030964042991399765,
-0.046287901699543,
-0.001448271912522614,
-0.09640270471572876,
-0.19240960478782654,
-0.011900178156793118,
0.055115774273872375,
-0.07407967001199722,
-0.10347197204828262,
-0.07018296420574188,
-0.014443431049585342,
0.1236252635717392,
-0.0330762080848217,
0.03684931993484497,
0.0801200419664383,
-0.03080660104751587,
0.1821020245552063,
0.209446519613266,
-0.055662546306848526,
-0.06500247865915298,
0.09898671507835388,
-0.18184880912303925,
-0.25020650029182434,
0.1954950988292694,
0.2144516557455063,
-0.253374844789505,
-0.1644304245710373,
-0.13670893013477325,
-0.009146995842456818,
-0.051323674619197845,
0.2712225317955017,
0.07485147565603256,
0.09308724850416183
] |
omim | https://www.omim.org/entry/252011 | rowjg6v | MITOCHONDRIAL COMPLEX II DEFICIENCY | C1855008 | 31,757 | mitochondrial complex ii deficiency. - Ptosis
- Ophthalmoplegia
- Pigmentary retinopathy
- Optic atrophy
- Nystagmus
- Impaired vision
CARDIOVASCULAR
Heart
- Hypertrophic cardiomyopathy
- Dilated cardiomyopathy
- Left ventricular noncompaction
SKELETAL
- Joint contractures
MUSCLE, SOFT TISSUES
- Hypotonia, neonatal
- Muscle weakness
- Exercise intolerance
- Ragged red fibers seen on muscle biopsy
- Abnormal mitochondria with paracrystalline inclusions seen on muscle biopsy
- Accumulated lipid droplets seen on muscle biopsy
NEUROLOGIC
Central Nervous System
- Psychomotor regression in infants
- Spasticity
- Hyperreflexia
- Extensor plantar responses
- Ataxia
- Cognitive impairment
- Dystonia
- Myoclonus
- Seizures
- Leukoencephalopathy, progressive
- Spongiform encephalomyelopathy
- Leigh syndrome (
245000
), in a subset of patients
- Kearns-Sayre syndrome (
530000
), in a subset of patients
METABOLIC FEATURES
- Lactic acidosis may occur with stress or infection
LABORATORY ABNORMALITIES
- Decreased activity of mitochondrial complex II (succinate dehydrogenase)
- Mildly increased serum lactate
MISCELLANEOUS
- Onset in first year of life | [
0.09767425060272217,
-0.08439043164253235,
0.06460808217525482,
-0.13056030869483948,
0.11865683645009995,
-0.19441619515419006,
-0.21245737373828888,
-0.17793306708335876,
-0.18098092079162598,
-0.0222488846629858,
0.17884458601474762,
-0.1808333843946457,
0.14683309197425842,
0.07947609573602676,
-0.06641081720590591,
0.10052891075611115,
0.06497111171483994,
0.03342478349804878,
-0.15676294267177582,
-0.20118111371994019,
-0.14896242320537567,
-0.17986169457435608,
0.006899992469698191,
0.17849676311016083,
-0.005044476594775915,
-0.13178250193595886,
0.23228654265403748,
-0.01198784913867712,
-0.0858568623661995,
0.1475008875131607,
-0.0655779168009758,
0.096165731549263,
0.4307326078414917,
-0.08278507739305496,
-0.01902257837355137,
-0.29284748435020447,
0.02614818699657917,
-0.21544510126113892,
0.17504163086414337,
-0.21612577140331268,
-0.17080076038837433,
-0.0723952129483223,
0.17795369029045105,
0.10661154985427856,
0.2781725227832794,
-0.07736127823591232,
-0.015215154737234116,
-0.019365372136235237,
0.16130678355693817,
0.09091268479824066,
0.13740050792694092,
-0.0005666171200573444,
-0.04216930642724037,
0.09546393156051636,
0.14916683733463287,
0.02671954222023487,
-0.12420449405908585,
0.09136312454938889,
-0.10955274105072021,
0.10545782744884491,
0.0989510789513588,
0.18260779976844788,
-0.06808559596538544,
-0.1566319465637207,
0.27038612961769104,
-0.1654874086380005,
0.1181243285536766,
0.14160694181919098,
0.3394332826137543,
0.07338076829910278,
0.1900482028722763,
-0.21403460204601288,
-0.05562935397028923,
0.3873147964477539,
0.05355171486735344,
0.056114859879016876,
0.024850748479366302,
0.03507876768708229,
0.008551881648600101,
-0.10321051627397537,
-0.049960970878601074,
-0.12716886401176453,
0.022585038095712662,
0.10359983146190643,
0.0430799275636673,
-0.04695510119199753,
0.1916734278202057,
-0.009419224224984646,
-0.06461209803819656,
-0.01934959925711155,
0.18953801691532135,
-0.11717969924211502,
0.08295579254627228,
-0.006954338867217302,
-0.05429382622241974,
-0.13223683834075928,
0.1070639118552208,
-0.15990294516086578,
0.03126467019319534,
-0.03880200907588005,
0.2222251445055008,
0.19153574109077454,
-0.3585398495197296,
-0.07864199578762054,
-0.07969711720943451,
0.01875106245279312,
-0.204322949051857,
-0.026143766939640045,
-0.2712620794773102,
0.14619866013526917,
0.018344445154070854,
-0.11656973510980606,
0.060774561017751694,
0.0034519420005381107,
-0.18926851451396942,
0.17477364838123322,
-0.00004672997602028772,
0.3282580077648163,
0.024493109434843063,
0.21212811768054962,
0.06384478509426117,
-0.027352413162589073,
0.01097100879997015,
0.11310878396034241,
0.04764532670378685,
0.09549906849861145,
0.014688193798065186,
0.05830751731991768,
0.25366631150245667,
-0.1337195187807083,
-0.033453233540058136,
-0.10389149934053421,
-0.2383798062801361,
0.267713725566864,
0.06710243970155716,
-0.13964703679084778,
-0.23620648682117462,
-0.26308098435401917,
0.04467262700200081,
-0.195843905210495,
-0.01463646162301302,
-0.15289977192878723,
0.31342047452926636,
0.23028047382831573,
0.022757692262530327,
-0.21985027194023132,
-0.024244898930191994,
-0.04807595908641815,
0.3165709972381592,
0.16321983933448792,
0.09678631275892258,
-0.30293259024620056,
0.040724970400333405,
0.06104133278131485,
-0.050905339419841766,
0.20159073173999786,
-0.11809825897216797,
-0.11366252601146698,
-0.22968731820583344,
0.1917087286710739,
-0.02010280266404152,
0.019897976890206337,
-0.18341681361198425,
-0.17048044502735138,
-0.2475728839635849,
0.018338872119784355,
-0.3103843331336975,
-0.007728199008852243,
0.045309726148843765,
-0.1941867172718048,
-0.12695342302322388,
0.2155558168888092,
-0.21198292076587677,
-0.09819439053535461,
0.07444608211517334,
0.20991362631320953,
0.060875747352838516,
-0.09586676210165024,
-0.15944267809391022,
-0.03340539336204529,
-0.014362281188368797,
0.05002615973353386,
-0.39079734683036804,
-0.011441180482506752,
0.14402948319911957,
-0.2498699128627777,
0.06203500181436539,
0.05076641961932182,
-0.4128427803516388,
-0.059358883649110794,
0.07834623754024506,
0.24472662806510925,
0.17392469942569733,
0.08730705082416534,
-0.1274360865354538,
-0.24450579285621643,
-0.10295223444700241,
-0.18029965460300446,
-0.09785056859254837,
0.017220815643668175,
0.2167581170797348,
-0.07368633151054382,
-0.023391347378492355,
0.01190857496112585,
-0.05829043686389923,
0.11848556995391846,
0.13004659116268158,
-0.1587170511484146,
0.06829415261745453,
0.07705886662006378,
-0.13833826780319214,
-0.10372282564640045,
-0.1095060259103775,
0.11032097041606903,
-0.017433946952223778,
0.13946428894996643,
-0.018336443230509758,
0.12129524350166321,
0.1803615391254425,
0.21645627915859222,
0.016970299184322357,
0.07606417685747147,
0.04432320594787598,
-0.39574044942855835,
-0.25162720680236816,
0.22459262609481812,
-0.37039679288864136,
0.019122911617159843,
0.09497290849685669,
-0.3099670112133026,
0.0034172486048191786,
-0.09960036724805832,
-0.2590934932231903,
-0.14467744529247284,
0.006405162159353495,
-0.13950158655643463,
0.008992125280201435,
0.20921488106250763,
0.18812164664268494,
0.030067073181271553,
-0.2620597779750824,
-0.016770726069808006,
-0.0011182082816958427,
0.2010359913110733,
-0.012774377129971981,
-0.154506653547287,
-0.012361065484583378,
0.3237205743789673,
-0.013155963271856308,
0.36133328080177307,
-0.15434472262859344,
0.06010689213871956,
0.09034764766693115,
-0.04039080813527107,
-0.36614990234375,
-0.1817571520805359,
-0.09143336117267609,
0.03818870335817337,
0.1765647828578949,
0.1451500505208969,
0.08407377451658249,
0.08740151673555374,
-0.14948417246341705,
-0.11126945167779922,
-0.24525322020053864,
-0.054052580147981644,
-0.04405653104186058,
0.13263702392578125,
0.05441535264253616,
-0.17100265622138977,
-0.16459277272224426,
0.29280367493629456,
0.2712082862854004,
0.11947723478078842,
-0.09057117998600006,
-0.03435717895627022,
0.12511196732521057,
0.32559043169021606,
0.0968896746635437,
-0.05626716464757919,
-0.18897795677185059,
-0.0012719623045995831,
-0.30042412877082825,
0.01864325813949108,
0.45271778106689453,
0.08125607669353485,
0.1669439673423767,
0.061016470193862915,
-0.06297120451927185,
-0.056560225784778595,
0.007228262722492218,
0.029355153441429138,
-0.3949601352214813,
-0.004201557952910662,
-0.10436339676380157,
-0.15251445770263672,
0.09317507594823837,
0.0635036900639534,
0.08307217806577682,
-0.08997272700071335,
0.05108942463994026,
0.26363104581832886,
0.01849563606083393,
0.18056778609752655,
-0.29043251276016235,
0.3604802191257477,
0.025315681472420692,
0.08582168072462082,
0.1803780347108841,
-0.16228623688220978,
-0.4164356589317322,
0.02549290470778942,
-0.20997555553913116,
-0.2107367217540741,
-0.09315294772386551,
0.10387200117111206,
-0.15932083129882812,
0.17782628536224365,
0.1869467943906784,
0.2083686888217926,
-0.03714969754219055,
0.12665274739265442,
0.11923306435346603,
0.28312182426452637,
-0.0973665863275528,
0.0920398160815239,
-0.05968865379691124,
0.2845723330974579,
-0.0755700170993805,
0.026058919727802277,
0.09107980877161026,
0.14466078579425812,
-0.06746511161327362,
-0.13138918578624725,
-0.029669685289263725,
0.13308502733707428,
0.2383945733308792,
-0.07532712817192078,
-0.14790767431259155,
-0.11632685363292694,
0.02178732119500637,
-0.4246464967727661,
-0.01052193995565176,
-0.05237662047147751,
0.05032064765691757,
0.06395071744918823,
0.10756520181894302,
0.10877861082553864,
0.2639791667461395,
-0.13233508169651031,
-0.2571878731250763,
0.16618016362190247,
-0.18189962208271027,
-0.2252037525177002,
0.04488236829638481,
-0.15922826528549194,
-0.09785281121730804,
0.18056456744670868,
0.10496900230646133,
0.16868728399276733,
-0.13261663913726807,
-0.03523143008351326,
0.21703584492206573,
-0.03037976659834385,
-0.18324626982212067,
-0.14920125901699066,
-0.054861824959516525,
0.039036571979522705,
0.36394208669662476,
0.05732977017760277,
0.16661350429058075,
-0.1363181471824646,
-0.040082965046167374,
0.04059009999036789,
-0.239161878824234,
0.15902410447597504,
-0.025753958150744438,
-0.06812585145235062,
0.15243680775165558,
0.06298243999481201,
0.04141851142048836,
0.19717887043952942,
-0.04537703096866608,
0.24301108717918396,
0.013565495610237122,
0.1522066593170166,
-0.19878873229026794,
0.3230292797088623,
0.2949867248535156,
-0.12208036333322525,
0.2652715742588043,
-0.013032357208430767,
0.04604101553559303,
0.18780528008937836,
0.2573511004447937,
0.22496160864830017,
-0.03246987238526344,
0.12649820744991302,
-0.13781698048114777,
-0.030050694942474365,
-0.12740854918956757,
-0.14391426742076874,
0.12542352080345154,
0.2446373850107193,
0.11654222756624222,
-0.11790814250707626,
0.1974794715642929,
0.21887007355690002,
-0.4529019594192505,
-0.0685541033744812,
-0.1990581452846527,
-0.05861871317028999,
-0.17799030244350433,
-0.061198655515909195,
-0.22110296785831451,
-0.06991688907146454,
0.1572064608335495,
0.22409307956695557,
-0.1246335431933403,
-0.022156544029712677,
-0.07784967124462128,
0.027316642925143242,
0.199717715382576,
-0.09264538437128067,
-0.11108598113059998,
-0.07962574809789658,
-0.10083717107772827,
0.054840393364429474,
0.30427315831184387,
0.029781589284539223,
0.13767418265342712,
0.2176515758037567,
-0.09911777824163437,
0.05254143103957176,
0.08479150384664536,
0.26061347126960754,
0.039749909192323685,
-0.10223473608493805,
-0.029504166916012764,
-0.09899460524320602,
0.17351451516151428,
0.1529608517885208,
0.0007451743585988879,
-0.059474699199199677,
-0.1532980352640152,
0.0025385995395481586,
0.2003972828388214,
0.14885418117046356,
0.05993570014834404,
-0.013942878693342209,
-0.16755585372447968,
-0.11617694795131683,
0.171164408326149,
0.006212673615664244,
-0.05703217163681984,
0.1592581570148468,
0.05229737609624863,
-0.021933728829026222,
-0.04962427541613579,
-0.18469443917274475,
0.056225914508104324,
0.10378821939229965,
0.24549193680286407,
-0.23903976380825043,
0.03375507891178131,
0.10278382897377014,
-0.13987334072589874,
-0.2344202995300293,
0.1022401824593544,
-0.048065148293972015,
0.15765121579170227,
0.004849469754844904,
0.05078700929880142,
0.3001338541507721,
-0.09865616261959076,
-0.1402185708284378,
-0.12433818727731705,
0.03737169876694679,
0.08807781338691711,
-0.12231679260730743,
0.04543982818722725,
-0.12125766277313232,
-0.04900271072983742,
-0.2999199330806732,
0.005899444222450256,
0.08022042363882065,
-0.16495180130004883,
-0.07920456677675247,
0.3462408781051636,
0.09437291324138641,
0.07588396221399307,
-0.14888274669647217,
0.03827635943889618,
0.27297255396842957,
-0.024876143783330917,
-0.16924011707305908,
0.06459332257509232,
-0.053884733468294144,
-0.19890698790550232,
-0.07814232259988785,
0.17649689316749573,
-0.21741488575935364,
-0.38240182399749756,
0.08367197960615158,
-0.2788420617580414,
-0.19937855005264282,
-0.20814432203769684,
-0.3041740357875824,
-0.1445997804403305,
0.27278321981430054,
0.168230339884758,
0.11202245950698853,
0.16192443668842316,
-0.30924463272094727,
0.1356646716594696,
-0.3265296220779419,
0.09964619576931,
0.3379680812358856,
0.058389563113451004,
-0.0821036621928215,
-0.22760650515556335,
-0.17224733531475067,
0.18114082515239716,
0.04884330555796623,
0.27454668283462524,
-0.07524246722459793,
-0.05450580269098282,
0.3422386348247528,
0.1638992428779602,
-0.011346430517733097,
-0.14807647466659546,
0.20039565861225128,
-0.3479686379432678,
0.07270299643278122,
0.08731602877378464,
0.011762523092329502,
0.052297595888376236,
-0.056325022131204605,
0.1789533495903015,
0.0845409482717514,
-0.016093609854578972,
0.12362868338823318,
0.036832842975854874,
0.05562514439225197,
0.17996646463871002,
-0.06877541542053223,
-0.0319453664124012,
0.12777835130691528,
0.10768329352140427,
0.28655198216438293,
-0.0928291454911232,
-0.02513500303030014,
0.1282069832086563,
0.03838278353214264,
-0.30599963665008545,
-0.21727122366428375,
0.09861567616462708,
-0.047656986862421036,
-0.3273260295391083,
-0.13659808039665222,
-0.24058474600315094,
-0.013668715953826904,
-0.14826074242591858,
0.305958092212677,
0.2775275409221649,
0.017595166340470314,
0.07916689664125443,
0.12049724906682968,
-0.007294906303286552,
-0.23570074141025543,
0.18560780584812164,
-0.041561923921108246,
0.09773934632539749,
-0.1303590089082718,
-0.20496141910552979,
0.12585735321044922,
-0.36306801438331604,
-0.11202894151210785,
-0.06963002681732178,
-0.04698438569903374,
-0.27110427618026733,
-0.14913971722126007,
0.0011936769587919116,
-0.2777528166770935,
0.09193357825279236,
0.025916965678334236,
0.020845657214522362,
0.029271939769387245,
0.26454102993011475,
0.01830829121172428,
0.13873815536499023,
-0.006495052482932806,
-0.17848140001296997,
0.06465267390012741,
0.14390020072460175,
-0.1493295431137085,
-0.007399057969450951,
-0.12098141759634018,
-0.014529751613736153,
0.07696877419948578,
-0.0010339523432776332,
0.4053698182106018,
0.13748297095298767,
0.00403937604278326,
-0.09660951048135757,
0.15888121724128723,
0.007803856860846281,
-0.06048176810145378,
0.1234191432595253,
-0.0008516551461070776,
-0.016105378046631813,
-0.21804651618003845,
0.125212624669075,
-0.11445833742618561,
0.17029455304145813,
0.005552021320909262,
0.2641010284423828,
-0.05244155600667,
0.39899876713752747,
-0.006534832064062357,
0.2918908894062042,
-0.04863462597131729,
0.24123701453208923,
-0.1696247160434723,
-0.16802360117435455,
0.1437140554189682,
0.07819546014070511,
-0.2087131291627884,
0.1939988136291504,
-0.046017762273550034,
0.04861541837453842,
0.3227565586566925,
0.06527145206928253,
0.2146911472082138,
-0.2503068745136261,
0.19466045498847961,
0.23261602222919464,
-0.028101976960897446,
-0.11867371201515198,
-0.019213205203413963,
-0.14293238520622253,
0.1489112377166748,
-0.22677695751190186,
0.18655763566493988,
-0.28053712844848633,
0.03964044153690338,
0.02931634895503521,
-0.3776136338710785,
-0.10069822520017624,
-0.09280792623758316,
0.20557372272014618,
-0.19008943438529968,
-0.3684535324573517,
0.3433418571949005,
0.2292160540819168,
-0.024340635165572166,
0.14983223378658295,
-0.10495499521493912,
-0.04835354909300804,
0.09606190770864487,
-0.23767274618148804,
0.1640235334634781,
0.1827932447195053,
0.1971731036901474,
-0.12723369896411896,
0.04169958829879761,
-0.16238421201705933,
0.20076434314250946,
-0.16044850647449493,
-0.05218661203980446,
-0.21635790169239044,
0.2005123794078827,
0.029580174013972282,
0.17908784747123718,
-0.011682040989398956,
0.04419228807091713,
-0.11376684904098511,
0.007219476159662008,
0.11868642270565033,
0.4019945561885834,
0.21354460716247559,
-0.3847123682498932,
-0.09388507902622223,
0.08372971415519714,
0.11605164408683777,
0.22943390905857086,
0.10159413516521454,
0.18340015411376953,
0.2777210772037506,
0.050706829875707626,
0.15111090242862701,
0.09121178090572357,
-0.022884422913193703,
0.038394346833229065,
-0.08895400166511536,
-0.055859483778476715,
0.3896201550960541,
-0.02933831699192524,
-0.0006051354575902224,
-0.1586758941411972,
0.048845093697309494,
0.14877727627754211,
0.005596092436462641,
0.133720263838768,
-0.142169788479805,
-0.19927442073822021,
0.01898459531366825,
-0.23324482142925262,
-0.08440206944942474,
0.11375807225704193,
0.00950252078473568,
-0.013587909750640392,
-0.052895836532115936,
0.22690652310848236,
-0.02125728316605091,
0.055749211460351944,
-0.09971591830253601,
0.1189177930355072,
-0.07160785049200058,
-0.10719133168458939,
-0.012182512320578098,
-0.07483449578285217,
-0.03444812446832657,
-0.01026340015232563,
0.1430795043706894,
0.317442387342453,
0.19208183884620667,
0.003027186030521989,
0.1646796613931656,
0.11187027394771576,
-0.03811197727918625,
0.06754395365715027,
-0.16569364070892334,
-0.08406359702348709,
-0.001382244867272675,
0.09265560656785965,
0.08072543144226074,
0.01629454456269741,
-0.12386692315340042,
-0.34906014800071716,
0.01863250508904457,
0.13040558993816376,
-0.04669256880879402,
-0.0833459347486496,
-0.03265645354986191,
-0.09849845618009567,
0.12133925408124924,
-0.08840146660804749,
-0.0911041796207428,
0.09510490298271179,
-0.13902196288108826,
0.12210965901613235,
0.1088607981801033,
0.04180664196610451,
-0.023606780916452408,
0.10011796653270721,
-0.06430698931217194,
-0.3112253248691559,
0.17224331200122833,
0.35774001479148865,
-0.30260172486305237,
-0.12906187772750854,
0.036621131002902985,
0.09026846289634705,
-0.07395707815885544,
0.23954325914382935,
0.034281015396118164,
0.1187577098608017
] |
omim | https://www.omim.org/entry/252011 | rowjg6v | MITOCHONDRIAL COMPLEX II DEFICIENCY | C1855008 | 31,757 | mitochondrial complex ii deficiency. ia
- Extensor plantar responses
- Ataxia
- Cognitive impairment
- Dystonia
- Myoclonus
- Seizures
- Leukoencephalopathy, progressive
- Spongiform encephalomyelopathy
- Leigh syndrome (
245000
), in a subset of patients
- Kearns-Sayre syndrome (
530000
), in a subset of patients
METABOLIC FEATURES
- Lactic acidosis may occur with stress or infection
LABORATORY ABNORMALITIES
- Decreased activity of mitochondrial complex II (succinate dehydrogenase)
- Mildly increased serum lactate
MISCELLANEOUS
- Onset in first year of life
- Highly variable phenotype
MOLECULAR BASIS
- Caused by mutation in the flavoprotein subunit of succinate dehydrogenase complex gene (SDHA,
600857.0001
)
- Caused by mutation in the succinate dehydrogenase complex assembly factor 1 gene (SDHAF1,
612848.0001
)
- Caused by mutation in the succinate dehydrogenase complex, subunit D, integral membrane protein gene (SDHD,
602690.0029
)
▲ Close | [
-0.041512586176395416,
0.07719826698303223,
0.14440582692623138,
-0.3214930593967438,
0.1514626145362854,
-0.10409536957740784,
0.12348135560750961,
-0.13825438916683197,
-0.08372345566749573,
0.047633979469537735,
0.12561482191085815,
0.03595997765660286,
0.18461035192012787,
0.017809517681598663,
0.09244102984666824,
0.2190948724746704,
0.0074119833298027515,
-0.19278106093406677,
-0.059440601617097855,
-0.05997747182846069,
-0.16160625219345093,
-0.08569866418838501,
0.10939937084913254,
0.2831958830356598,
0.03824548050761223,
-0.011306357569992542,
0.036725275218486786,
0.12819647789001465,
-0.00970464013516903,
0.050948165357112885,
-0.1419253647327423,
0.05694591999053955,
0.0344122052192688,
-0.18361309170722961,
-0.030568355694413185,
-0.3050593435764313,
-0.17302697896957397,
-0.060945335775613785,
0.11260391026735306,
-0.1049504354596138,
-0.22237803041934967,
-0.08254015445709229,
0.17667074501514435,
-0.06836025416851044,
0.3062942922115326,
-0.004498569294810295,
0.18318168818950653,
0.0572458878159523,
0.06348913162946701,
0.09463188797235489,
0.07330425083637238,
0.0533510260283947,
-0.020618874579668045,
-0.19626648724079132,
0.34747883677482605,
-0.015385877341032028,
0.0006679898942820728,
0.21370896697044373,
-0.27475714683532715,
-0.039921343326568604,
-0.13533298671245575,
0.23304355144500732,
-0.11652795225381851,
-0.10875657200813293,
0.15338356792926788,
0.07015922665596008,
-0.046344831585884094,
0.2326764464378357,
0.08772649616003036,
0.11656273156404495,
0.17262183129787445,
-0.04054348170757294,
0.11122071743011475,
0.17076972126960754,
-0.02443867176771164,
0.13463842868804932,
0.24014030396938324,
-0.08895059674978256,
0.1496085375547409,
-0.15385304391384125,
-0.24639233946800232,
0.10927458852529526,
0.0707884430885315,
0.2073892056941986,
-0.05720532312989235,
0.21619395911693573,
0.1370435357093811,
0.19835145771503448,
-0.05861219763755798,
0.3141413927078247,
0.13518951833248138,
0.1579953134059906,
0.07023017108440399,
-0.09998877346515656,
0.061494648456573486,
-0.26236492395401,
0.054856155067682266,
-0.11328290402889252,
0.0012022553710266948,
0.06730871647596359,
0.21231427788734436,
-0.0031255728099495173,
-0.2133585810661316,
0.02432955428957939,
-0.04061577096581459,
-0.024372858926653862,
-0.16021348536014557,
-0.0564306378364563,
-0.008001070469617844,
0.24398688971996307,
0.18346787989139557,
0.1102038323879242,
-0.0781368836760521,
0.01271554734557867,
-0.10559460520744324,
0.04724641144275665,
0.26788443326950073,
0.36341819167137146,
0.006034146528691053,
0.14656154811382294,
-0.035201989114284515,
-0.027028655633330345,
0.25643396377563477,
-0.005460030864924192,
-0.04921101778745651,
0.0897877886891365,
0.02210339903831482,
-0.07933776080608368,
0.264741986989975,
-0.14998026192188263,
-0.2089238166809082,
0.11195793747901917,
-0.21714068949222565,
0.19520549476146698,
-0.18461346626281738,
-0.2279863953590393,
-0.26095137000083923,
-0.28498566150665283,
-0.1335620880126953,
-0.0838138684630394,
-0.03943338245153427,
-0.04530424252152443,
0.17746424674987793,
0.16226281225681305,
-0.04474608972668648,
0.08715255558490753,
0.02302507311105728,
-0.10973899066448212,
0.23009411990642548,
0.1341751217842102,
0.1016332358121872,
-0.22209890186786652,
0.11688701808452606,
-0.19653823971748352,
0.010775838978588581,
0.2176038771867752,
-0.049203306436538696,
0.17633648216724396,
-0.029983434826135635,
0.0035284538753330708,
0.006866284646093845,
0.012995573692023754,
-0.09883348643779755,
-0.32242199778556824,
-0.09669177234172821,
-0.10648931562900543,
-0.18014292418956757,
0.11391301453113556,
0.0019815980922430754,
-0.3351171314716339,
-0.3171745538711548,
0.18691648542881012,
-0.0808318704366684,
0.10361938923597336,
0.23284484446048737,
-0.0084999930113554,
-0.07352639734745026,
0.059921104460954666,
-0.15858328342437744,
0.0690082386136055,
0.08461494743824005,
-0.10860568284988403,
-0.23979736864566803,
0.04357417672872543,
0.05709487572312355,
-0.048750754445791245,
0.0830511599779129,
0.1289120763540268,
-0.1047646775841713,
0.18457159399986267,
0.2879745662212372,
0.09809114784002304,
0.11919263005256653,
0.017678171396255493,
-0.21814365684986115,
0.0727819874882698,
-0.13937169313430786,
-0.1758723109960556,
-0.07477539032697678,
-0.03053041733801365,
0.14329591393470764,
0.009533686563372612,
-0.0005705454968847334,
0.043197859078645706,
0.05999523401260376,
0.14169050753116608,
0.15300433337688446,
-0.04385635629296303,
-0.03755223751068115,
0.08851111680269241,
0.03855161741375923,
0.18427510559558868,
-0.23426809906959534,
0.14008626341819763,
-0.11260617524385452,
-0.022650044411420822,
0.09096501767635345,
-0.009531859308481216,
0.053527846932411194,
0.11083206534385681,
-0.017234303057193756,
-0.06296907365322113,
0.004204650409519672,
-0.3746693730354309,
0.07138725370168686,
0.2799154818058014,
-0.18130311369895935,
-0.008502830751240253,
0.12453625351190567,
-0.008084587752819061,
0.20380279421806335,
-0.07259993255138397,
0.0053314026445150375,
-0.17990417778491974,
-0.13736377656459808,
-0.14836975932121277,
0.12312205135822296,
-0.10457613319158554,
-0.004728084430098534,
0.05224495753645897,
-0.4095352590084076,
-0.053007155656814575,
-0.05709904432296753,
0.19484007358551025,
-0.045821186155080795,
-0.11919790506362915,
-0.0035149853210896254,
-0.029959896579384804,
0.06918437778949738,
0.12755292654037476,
0.05438125506043434,
0.11758723855018616,
-0.011248545721173286,
-0.11077108979225159,
-0.18327529728412628,
-0.23759368062019348,
-0.12392894178628922,
-0.12633909285068512,
-0.0598747693002224,
0.16629724204540253,
0.1516442447900772,
0.04040120914578438,
-0.2734164595603943,
-0.015848640352487564,
-0.24901781976222992,
0.034794073551893234,
-0.13297052681446075,
-0.010705920867621899,
0.1101614311337471,
-0.0160048995167017,
-0.0015898686833679676,
0.2506435215473175,
0.3643907308578491,
0.13874974846839905,
0.02956506423652172,
0.14294515550136566,
-0.08848711848258972,
0.32388389110565186,
0.2494770884513855,
-0.19361980259418488,
-0.21781803667545319,
0.11000729352235794,
-0.3244793117046356,
-0.008074616082012653,
0.3017295300960541,
0.056341174989938736,
0.24763117730617523,
0.04620181769132614,
-0.11340875923633575,
-0.01189331989735365,
-0.12322279810905457,
0.059900447726249695,
-0.30495506525039673,
-0.04620039090514183,
-0.02283807098865509,
-0.10525665432214737,
0.10019998997449875,
0.01468766201287508,
0.05694855749607086,
-0.039750777184963226,
0.16701704263687134,
0.05745721980929375,
0.024518953636288643,
-0.03121917136013508,
-0.3007763624191284,
0.18440201878547668,
0.1715569645166397,
0.09102275222539902,
0.017079081386327744,
0.01599859818816185,
-0.5598911643028259,
0.0020057151559740305,
-0.2316657155752182,
0.12800884246826172,
-0.10926895588636398,
-0.029315704479813576,
-0.040231697261333466,
0.1277954876422882,
-0.0452621653676033,
-0.02136116661131382,
-0.021128535270690918,
0.11409781128168106,
0.22839346528053284,
0.11211343109607697,
0.07905261218547821,
0.2154567837715149,
-0.06794733554124832,
0.13600178062915802,
-0.06629039347171783,
0.19138287007808685,
0.3375419080257416,
0.3563133478164673,
-0.11087718605995178,
-0.08060645312070847,
-0.014717542566359043,
0.08171331882476807,
0.2697892487049103,
0.054753631353378296,
-0.24812911450862885,
-0.26455843448638916,
0.11295878142118454,
-0.39193713665008545,
-0.17556743323802948,
-0.07312410324811935,
0.02310711145401001,
-0.024558337405323982,
0.07637760043144226,
0.06542186439037323,
0.21178147196769714,
-0.1340705156326294,
-0.4136122763156891,
0.14721933007240295,
0.042821962386369705,
-0.1977812796831131,
0.0016844409983605146,
-0.118459552526474,
-0.16936688125133514,
0.2750724256038666,
0.01243628654628992,
-0.07298535108566284,
0.003803972154855728,
-0.024933144450187683,
0.10221546143293381,
-0.19708234071731567,
-0.15846191346645355,
-0.06865659356117249,
0.11438271403312683,
0.16903577744960785,
0.24150614440441132,
0.0015748345758765936,
0.18245136737823486,
-0.17052412033081055,
-0.13031978905200958,
0.028346676379442215,
-0.1765287220478058,
0.05352095142006874,
-0.028067678213119507,
0.10081493854522705,
-0.024628233164548874,
-0.05122116580605507,
-0.04977110028266907,
0.1876114010810852,
0.0638141855597496,
0.22949545085430145,
-0.12976768612861633,
0.1899983286857605,
-0.27976810932159424,
0.14988918602466583,
-0.02303350903093815,
-0.07651697844266891,
0.17605304718017578,
0.09693743288516998,
-0.04922027140855789,
0.02904120460152626,
0.006649309303611517,
0.27128615975379944,
-0.026555178686976433,
0.15545810759067535,
-0.23196730017662048,
-0.013136085122823715,
-0.09460606426000595,
-0.18681450188159943,
0.017849057912826538,
-0.018419701606035233,
0.08147676289081573,
0.03607051447033882,
0.25919145345687866,
0.21557505428791046,
-0.22419866919517517,
0.0018175827572122216,
-0.3337479531764984,
0.014238367788493633,
-0.0756235271692276,
0.12708204984664917,
-0.3085600733757019,
-0.10827382653951645,
0.10806521773338318,
0.211417093873024,
-0.05851582810282707,
0.05327196791768074,
-0.16185683012008667,
-0.1795765906572342,
0.2615058124065399,
-0.1425403356552124,
0.08574055880308151,
0.08775065839290619,
0.16426053643226624,
0.06722143292427063,
0.24525707960128784,
-0.13263240456581116,
0.10700827091932297,
-0.07146163284778595,
-0.1718558818101883,
-0.017869101837277412,
0.046767834573984146,
0.1673438996076584,
-0.052625324577093124,
0.1735260933637619,
0.025186922401189804,
0.0033494438976049423,
-0.01041837316006422,
0.21283204853534698,
0.07314368337392807,
-0.06566953659057617,
-0.14380960166454315,
0.20022402703762054,
0.2694868743419647,
0.16134047508239746,
0.03292374685406685,
0.004744709003716707,
-0.1614225208759308,
-0.11749546229839325,
0.03468112647533417,
-0.2532869875431061,
-0.19468772411346436,
0.1638711541891098,
0.11827975511550903,
-0.2432977557182312,
-0.07065267115831375,
-0.2958996295928955,
0.22552631795406342,
0.026226641610264778,
0.2533417046070099,
-0.23596619069576263,
0.046258460730314255,
0.4221826493740082,
-0.118980273604393,
-0.12161432951688766,
0.1145496591925621,
-0.17400023341178894,
0.11923713237047195,
-0.09519480168819427,
-0.019302302971482277,
-0.08100521564483643,
0.047667454928159714,
0.06605811417102814,
0.04438357800245285,
0.08054544776678085,
0.2412477284669876,
-0.003919856622815132,
0.06422001868486404,
-0.2823750376701355,
-0.15797869861125946,
0.033365558832883835,
0.08481808006763458,
0.03988602012395859,
-0.1583884209394455,
-0.06958476454019547,
0.2545396089553833,
-0.020168282091617584,
0.032331615686416626,
-0.09718694537878036,
0.14506980776786804,
0.2938590943813324,
-0.1192883774638176,
-0.03773638233542442,
0.04379761219024658,
-0.16420352458953857,
-0.18240390717983246,
0.1421295553445816,
0.16395770013332367,
-0.15208746492862701,
0.07189765572547913,
0.033357057720422745,
-0.12617601454257965,
-0.15855638682842255,
-0.19124740362167358,
-0.3033197820186615,
-0.13843092322349548,
0.43726280331611633,
0.05681717023253441,
-0.0866299420595169,
-0.02188700996339321,
-0.197576105594635,
0.07627811282873154,
-0.17764174938201904,
0.19805006682872772,
0.2954782545566559,
0.23877419531345367,
-0.15942330658435822,
-0.0318683423101902,
-0.26128050684928894,
0.2905429005622864,
-0.019231043756008148,
0.1337369680404663,
-0.17128777503967285,
0.23956181108951569,
0.06512921303510666,
-0.018414165824651718,
-0.09825471043586731,
-0.16179972887039185,
0.0959293469786644,
-0.3704189360141754,
0.23423834145069122,
-0.06814465671777725,
0.19519244134426117,
0.030104657635092735,
-0.16623054444789886,
-0.10269414633512497,
0.11984225362539291,
-0.09542348980903625,
-0.14569252729415894,
0.02658490277826786,
0.03416230157017708,
0.20474091172218323,
-0.226730078458786,
-0.045544564723968506,
-0.08215832710266113,
0.27112919092178345,
0.18417692184448242,
-0.026695406064391136,
0.0485205240547657,
0.03949885442852974,
0.04741663485765457,
-0.25886455178260803,
0.03424752131104469,
0.1456000953912735,
0.0629696473479271,
-0.23549312353134155,
-0.024435758590698242,
0.18281590938568115,
-0.025702593848109245,
-0.027720607817173004,
0.1267269104719162,
-0.028616031631827354,
-0.044410571455955505,
0.16598553955554962,
-0.010020124725997448,
-0.05033934488892555,
-0.2587774991989136,
0.010605787858366966,
-0.045623064041137695,
-0.1996275931596756,
0.03370142728090286,
-0.2490091174840927,
0.016897793859243393,
-0.22318428754806519,
-0.24684420228004456,
0.16635346412658691,
0.15230692923069,
-0.19979985058307648,
-0.27195850014686584,
0.0343325100839138,
-0.13977113366127014,
0.08308788388967514,
-0.06166480481624603,
0.1253919154405594,
0.0755893662571907,
0.2170311063528061,
-0.10616196691989899,
0.022885318845510483,
0.00375386793166399,
0.07570435106754303,
0.19774915277957916,
0.16491010785102844,
-0.07144802808761597,
0.0373721644282341,
-0.1200212612748146,
-0.001970642013475299,
0.12857457995414734,
-0.007585130166262388,
0.16687725484371185,
0.10070472210645676,
0.05722628906369209,
0.132452130317688,
0.0925169438123703,
-0.015281502157449722,
-0.2763516902923584,
0.15702179074287415,
0.15425798296928406,
-0.030706794932484627,
-0.37571823596954346,
0.022372888401150703,
-0.05968718230724335,
-0.06254144757986069,
-0.009816820733249187,
0.1654655933380127,
-0.14927278459072113,
0.3609408140182495,
0.04392355680465698,
0.1326540857553482,
0.06702892482280731,
0.22444449365139008,
-0.1425410360097885,
0.11128957569599152,
-0.017804887145757675,
0.06097094342112541,
-0.22499023377895355,
0.17445072531700134,
0.06560766696929932,
0.11155091971158981,
0.24939890205860138,
0.19434255361557007,
-0.0018210761481896043,
-0.03183060884475708,
0.015130824409425259,
-0.0477450005710125,
0.24998563528060913,
-0.015433644875884056,
0.020448962226510048,
-0.20401260256767273,
0.190458282828331,
-0.039374444633722305,
0.2722029387950897,
-0.3131689429283142,
0.17999251186847687,
0.009925016202032566,
-0.2608775198459625,
-0.07986447215080261,
-0.13962413370609283,
0.23680393397808075,
-0.00309364078566432,
0.006643593776971102,
0.23973724246025085,
0.10550526529550552,
-0.14608153700828552,
0.008051487617194653,
-0.14106491208076477,
-0.02776913158595562,
-0.2580208480358124,
-0.13027168810367584,
-0.09895098209381104,
-0.04923807084560394,
0.11835908144712448,
-0.05761696770787239,
0.06502452492713928,
0.01879981718957424,
0.12867115437984467,
-0.32491591572761536,
-0.21662704646587372,
-0.04898720234632492,
0.08097375184297562,
0.036664679646492004,
0.14072249829769135,
0.07355809211730957,
-0.21556077897548676,
-0.11193756014108658,
-0.18180212378501892,
-0.059149958193302155,
0.188146710395813,
0.03822711482644081,
-0.2345379739999771,
-0.11387108266353607,
0.08462295681238174,
-0.13330063223838806,
0.30202773213386536,
0.15031485259532928,
0.15305326879024506,
0.4155312180519104,
-0.13475792109966278,
0.03873205929994583,
-0.07327252626419067,
0.32192087173461914,
-0.034698594361543655,
-0.04233198240399361,
0.10281999409198761,
0.37482136487960815,
0.16974005103111267,
-0.051863908767700195,
-0.1756199300289154,
0.03802509605884552,
0.21139118075370789,
-0.22727885842323303,
0.1537790447473526,
-0.03912404552102089,
-0.11275136470794678,
-0.049105338752269745,
-0.1215737909078598,
-0.057082921266555786,
0.08138832449913025,
-0.00825365912169218,
0.07059323787689209,
-0.09049443900585175,
0.21791571378707886,
0.09392275661230087,
0.09803599119186401,
-0.09750811755657196,
0.1691640019416809,
0.07521834969520569,
-0.22923851013183594,
-0.045518286526203156,
-0.2118399739265442,
0.07392887026071548,
0.1066100224852562,
0.010195446200668812,
0.09713581949472427,
-0.04745928943157196,
0.046309977769851685,
0.036817602813243866,
-0.00785995926707983,
-0.17423690855503082,
-0.040333040058612823,
-0.2260298877954483,
0.0981467068195343,
-0.05773420259356499,
-0.11442189663648605,
0.12689559161663055,
0.19497080147266388,
-0.13298138976097107,
-0.26245546340942383,
-0.18646009266376495,
-0.03825734928250313,
-0.14275138080120087,
0.030680324882268906,
0.02656937763094902,
-0.03185945376753807,
-0.2508411705493927,
-0.11340399086475372,
-0.09972751140594482,
-0.0534803532063961,
0.05965587869286537,
0.07258553802967072,
0.17541861534118652,
-0.061473410576581955,
0.053687192499637604,
-0.0166215468198061,
-0.06838147342205048,
-0.3726404011249542,
0.1815429925918579,
0.22509843111038208,
0.11174027621746063,
-0.04631160944700241,
0.1339607685804367,
0.013191300444304943,
-0.20338989794254303,
0.06925643235445023,
-0.05841973051428795,
0.15698952972888947
] |
omim | https://www.omim.org/entry/252011 | rowjg6v | MITOCHONDRIAL COMPLEX II DEFICIENCY | C1855008 | 31,757 | mitochondrial complex ii deficiency. - Onset in first year of life
- Highly variable phenotype
MOLECULAR BASIS
- Caused by mutation in the flavoprotein subunit of succinate dehydrogenase complex gene (SDHA,
600857.0001
)
- Caused by mutation in the succinate dehydrogenase complex assembly factor 1 gene (SDHAF1,
612848.0001
)
- Caused by mutation in the succinate dehydrogenase complex, subunit D, integral membrane protein gene (SDHD,
602690.0029
)
▲ Close | [
0.06907673925161362,
0.19469773769378662,
0.10322444885969162,
-0.3736981451511383,
0.13418138027191162,
0.037272028625011444,
0.10372631251811981,
-0.22472776472568512,
-0.1079457700252533,
-0.10291040688753128,
-0.018459491431713104,
0.14580649137496948,
0.22965018451213837,
-0.022068362683057785,
0.07971438020467758,
0.2833027243614197,
0.1447131186723709,
0.0023968007881194353,
0.003001932054758072,
-0.050598274916410446,
-0.07563618570566177,
-0.16315226256847382,
0.022182025015354156,
0.2041226327419281,
0.01595090888440609,
-0.0008120654965750873,
0.10090330243110657,
0.024804724380373955,
-0.060819342732429504,
-0.052247609943151474,
0.05066999793052673,
-0.002752007683739066,
0.0870288535952568,
-0.1723867803812027,
0.007118709851056337,
-0.20779113471508026,
-0.0737834945321083,
0.007079357281327248,
0.16437692940235138,
-0.17032532393932343,
-0.14896774291992188,
-0.01917351223528385,
0.07701952010393143,
-0.02340514585375786,
0.05463001877069473,
0.16369353234767914,
0.2670467495918274,
0.03105992265045643,
0.15847955644130707,
0.26404789090156555,
0.0028138570487499237,
-0.050985414534807205,
0.20467378199100494,
-0.26531746983528137,
0.32244402170181274,
0.052215367555618286,
0.12491665035486221,
0.08711352944374084,
-0.26498883962631226,
-0.10597245395183563,
-0.11812803149223328,
0.22276277840137482,
-0.023973191156983376,
-0.14290837943553925,
0.041450489312410355,
0.05042798072099686,
-0.15166819095611572,
0.14345663785934448,
0.15932464599609375,
0.08412918448448181,
0.21095144748687744,
-0.05644742399454117,
0.12227239459753036,
0.16367679834365845,
-0.07537960261106491,
0.11863480508327484,
0.20108185708522797,
-0.10448858141899109,
0.164372056722641,
-0.19420979917049408,
-0.10822999477386475,
0.0555630661547184,
0.09533586353063583,
0.1983482837677002,
-0.09363067895174026,
0.17708316445350647,
0.08902328461408615,
0.023773914203047752,
-0.06468173116445541,
0.34327685832977295,
0.22917698323726654,
0.06776949763298035,
0.13972516357898712,
-0.1182115226984024,
0.22068428993225098,
-0.19146452844142914,
0.060755446553230286,
-0.052641596645116806,
-0.046414922922849655,
0.07944486290216446,
0.1866919845342636,
0.003930459264665842,
-0.1672910898923874,
-0.022850096225738525,
0.014061647467315197,
-0.13809512555599213,
-0.283080518245697,
0.05578988045454025,
0.08320628851652145,
0.12297201156616211,
-0.02496146596968174,
0.001309471088461578,
-0.1660117208957672,
0.004528756253421307,
0.10184686630964279,
0.08721110224723816,
0.23324841260910034,
0.3029358983039856,
-0.09829472750425339,
-0.045224208384752274,
-0.06571041792631149,
-0.008023333735764027,
0.2292066216468811,
-0.18668390810489655,
-0.0565800778567791,
0.17517805099487305,
0.008221208117902279,
-0.1067759245634079,
0.21071134507656097,
-0.06594700366258621,
-0.23447248339653015,
0.07826648652553558,
-0.027877766638994217,
0.13310058414936066,
-0.1355336308479309,
-0.1884085237979889,
-0.16521330177783966,
-0.27469301223754883,
0.028624890372157097,
-0.094173364341259,
0.003261214355006814,
-0.008746644482016563,
0.1640377789735794,
0.1551760584115982,
-0.05576746165752411,
-0.02825303003191948,
0.12927350401878357,
-0.032280001789331436,
0.18660017848014832,
0.14762918651103973,
0.327915221452713,
-0.11658262461423874,
0.281246155500412,
-0.22858597338199615,
-0.06123067066073418,
0.0035539481323212385,
-0.08402203023433685,
0.13823764026165009,
-0.09282294660806656,
0.02133094146847725,
0.08338947594165802,
-0.04796992987394333,
0.09257565438747406,
-0.18959595263004303,
0.08988895267248154,
-0.14677183330059052,
-0.18848904967308044,
0.06839408725500107,
-0.01800904981791973,
-0.20510071516036987,
-0.21908780932426453,
0.049200717359781265,
-0.12568336725234985,
0.017920520156621933,
0.24218454957008362,
0.05499637871980667,
-0.14664380252361298,
0.14064696431159973,
-0.09055770188570023,
-0.008974484167993069,
-0.026428749784827232,
-0.07209325581789017,
-0.26820966601371765,
-0.00636700727045536,
-0.09405740350484848,
-0.10586746037006378,
0.2425483614206314,
0.2044817954301834,
-0.23635900020599365,
0.18271465599536896,
0.21924881637096405,
0.05873003974556923,
0.06692357361316681,
0.016012927517294884,
-0.03878806158900261,
-0.025580868124961853,
-0.12001004070043564,
-0.23911000788211823,
-0.17084182798862457,
-0.24434123933315277,
0.3026905655860901,
0.05401322990655899,
0.01899750903248787,
-0.008200990036129951,
0.05491606146097183,
0.12431415170431137,
0.09708987176418304,
-0.09867838025093079,
-0.042828358709812164,
0.21952788531780243,
0.09207743406295776,
0.22553260624408722,
-0.25198662281036377,
0.1806330531835556,
-0.12634435296058655,
-0.10072702914476395,
-0.10132002085447311,
-0.09342572093009949,
0.020364247262477875,
0.08567137271165848,
0.00357718369923532,
-0.07255396991968155,
-0.05395917221903801,
-0.2750275731086731,
0.017130142077803612,
0.1626979410648346,
-0.10369528830051422,
0.07152258604764938,
0.11194349080324173,
-0.06681514531373978,
0.20122501254081726,
-0.1583731472492218,
0.035673562437295914,
-0.019948000088334084,
-0.20311208069324493,
-0.035426560789346695,
0.02808348461985588,
-0.0009718702058307827,
0.105202317237854,
-0.11456254124641418,
-0.3627431392669678,
-0.0652286484837532,
0.031346920877695084,
0.14314500987529755,
-0.09403710812330246,
-0.12349774688482285,
0.012789059430360794,
0.15112532675266266,
-0.010114769451320171,
0.08963342010974884,
0.030521826818585396,
0.012299117632210255,
-0.04845845699310303,
-0.053130313754081726,
-0.2630777657032013,
-0.20717427134513855,
-0.14455318450927734,
-0.03256833925843239,
0.008054505102336407,
0.09696575254201889,
0.15980418026447296,
-0.0845542773604393,
-0.1516263335943222,
0.06737250834703445,
-0.20689980685710907,
0.027179846540093422,
-0.0569131039083004,
0.0872538760304451,
0.04091659560799599,
-0.15855149924755096,
-0.11523478478193283,
0.14989854395389557,
0.25849857926368713,
0.0150834359228611,
-0.07378364354372025,
0.053924743086099625,
0.034023258835077286,
0.15109771490097046,
0.15086807310581207,
0.0007076913025230169,
-0.14378297328948975,
0.05442989617586136,
-0.19321809709072113,
0.13433048129081726,
0.23829743266105652,
0.10809653997421265,
0.16216719150543213,
0.1225542426109314,
-0.1133662536740303,
-0.0037207859568297863,
-0.12025264650583267,
-0.013488098978996277,
-0.33171969652175903,
0.14196518063545227,
0.042453374713659286,
-0.0020910517778247595,
0.0017841417575255036,
-0.10156291723251343,
0.1465078890323639,
-0.14488019049167633,
-0.007181248627603054,
0.026257477700710297,
-0.027943376451730728,
-0.01851671002805233,
-0.1648818999528885,
0.07858020812273026,
0.3389894366264343,
0.0872587189078331,
0.050224170088768005,
0.2078944593667984,
-0.34135574102401733,
-0.08320046961307526,
-0.237616166472435,
0.08477292954921722,
-0.20886284112930298,
0.06119818240404129,
-0.30006834864616394,
0.004692543763667345,
-0.0371500588953495,
0.014534304849803448,
-0.011829210445284843,
0.1165173351764679,
0.1590508669614792,
0.18198615312576294,
0.02469600737094879,
0.09661342203617096,
-0.16485440731048584,
0.08122225850820541,
-0.06941967457532883,
0.1604928970336914,
0.20959222316741943,
0.36707332730293274,
-0.17964287102222443,
-0.06746386736631393,
-0.004200586583465338,
0.0337216891348362,
0.134397953748703,
-0.09388832002878189,
-0.10356872528791428,
-0.1446906179189682,
0.1415150761604309,
-0.2956373691558838,
-0.2418784350156784,
-0.10322903841733932,
-0.14409084618091583,
-0.03740094229578972,
0.18928076326847076,
-0.057249534875154495,
0.2446666657924652,
-0.17185339331626892,
-0.36927708983421326,
-0.041903056204319,
-0.025665976107120514,
-0.230684295296669,
0.13555879890918732,
-0.18287554383277893,
-0.19784551858901978,
0.1689431518316269,
0.13804833590984344,
-0.1195700392127037,
-0.010587343946099281,
0.005536221899092197,
0.20899412035942078,
-0.18338176608085632,
0.00025205648853443563,
0.02094287984073162,
0.12604300677776337,
0.20206108689308167,
0.07872390002012253,
0.03632568567991257,
0.017309051007032394,
0.012410353869199753,
-0.09118149429559708,
0.03081713616847992,
-0.11880190670490265,
0.10903769731521606,
-0.05938060209155083,
0.09369370341300964,
0.09458756446838379,
-0.0704440101981163,
-0.05459807440638542,
0.06940826773643494,
0.165182426571846,
0.05245770141482353,
0.008547023870050907,
0.17789870500564575,
-0.14327335357666016,
0.09422710537910461,
-0.0651627853512764,
-0.07651051133871078,
0.014710042625665665,
0.1148514449596405,
0.10782751441001892,
-0.07467466592788696,
0.051904331892728806,
0.3498586416244507,
0.10819005221128464,
-0.04134294390678406,
-0.14924268424510956,
-0.11789470165967941,
-0.1311107724905014,
-0.3340532183647156,
0.010047693736851215,
0.027661612257361412,
-0.07241136580705643,
0.021770641207695007,
0.21531720459461212,
0.34747952222824097,
-0.13343162834644318,
0.036665868014097214,
-0.09176331013441086,
0.08468745648860931,
-0.06671954691410065,
-0.13111919164657593,
-0.2547765374183655,
-0.0017801389330998063,
-0.06241774931550026,
0.08842961490154266,
-0.09199625998735428,
0.05927106738090515,
-0.18443845212459564,
-0.147914856672287,
0.3444589674472809,
-0.15966184437274933,
0.2122388482093811,
0.05548841133713722,
0.20392011106014252,
0.036708634346723557,
0.17723610997200012,
-0.08262670040130615,
0.07956092059612274,
-0.15680243074893951,
-0.19724982976913452,
-0.08036569505929947,
0.0400514118373394,
0.1946551352739334,
0.008926182985305786,
0.14073747396469116,
-0.12189240753650665,
0.09291630238294601,
0.02211649902164936,
0.09947802126407623,
-0.04345383122563362,
-0.100273497402668,
-0.22288236021995544,
0.1574612259864807,
0.25274670124053955,
0.12211529910564423,
0.047330278903245926,
0.1658588945865631,
0.08739529550075531,
-0.08705174922943115,
0.07687503844499588,
-0.1588471382856369,
-0.18490292131900787,
0.19504541158676147,
0.011426463723182678,
-0.2300892174243927,
-0.0762859582901001,
-0.3012063503265381,
0.1750398874282837,
0.1462232619524002,
0.25893405079841614,
-0.08661393821239471,
0.03935975953936577,
0.1802901029586792,
-0.1249270886182785,
-0.09307663142681122,
0.06841199845075607,
-0.05357692763209343,
0.07000434398651123,
-0.023143189027905464,
0.03280586376786232,
-0.02167806588113308,
-0.07236066460609436,
0.04455915465950966,
0.06236015260219574,
0.08612558245658875,
0.18000157177448273,
0.1204359158873558,
0.11233069747686386,
-0.272943913936615,
-0.11361168324947357,
-0.05351756140589714,
0.03430650010704994,
-0.1217736154794693,
-0.1318938434123993,
-0.07117114216089249,
0.26102396845817566,
-0.05430856719613075,
0.07426497340202332,
0.004296641331166029,
0.1845209151506424,
0.325676828622818,
-0.03946152701973915,
-0.07561233639717102,
-0.046829141676425934,
-0.16268351674079895,
-0.11843205988407135,
0.18099169433116913,
0.1858929544687271,
-0.07416591048240662,
0.08619887381792068,
0.24968771636486053,
-0.16130518913269043,
-0.06315063685178757,
-0.22004541754722595,
-0.3204808235168457,
0.014987166970968246,
0.36916980147361755,
0.060593340545892715,
-0.12630273401737213,
-0.09130533039569855,
-0.1346970945596695,
0.0134279178455472,
-0.171759232878685,
0.07083246111869812,
0.176894873380661,
0.25834569334983826,
-0.11412623524665833,
0.03370373323559761,
-0.21001501381397247,
0.3485141396522522,
0.09605484455823898,
0.05641796439886093,
-0.17690064013004303,
0.17465154826641083,
0.1427571326494217,
-0.04637536406517029,
-0.10666430741548538,
-0.0178602933883667,
-0.050611063838005066,
-0.48856186866760254,
0.14150382578372955,
0.12210560590028763,
-0.007183686830103397,
0.1310051530599594,
-0.18824933469295502,
-0.2364301234483719,
0.09526216238737106,
-0.01643170230090618,
-0.07513705641031265,
-0.02331068553030491,
0.013223639689385891,
0.11162473261356354,
-0.11226963996887207,
-0.07686283439397812,
-0.18204213678836823,
0.1682705581188202,
0.18388569355010986,
-0.02785618044435978,
-0.05647234618663788,
-0.005794046446681023,
0.10369887948036194,
-0.26795700192451477,
-0.05522090941667557,
0.10032742470502853,
0.03464297950267792,
-0.16726335883140564,
-0.1422986090183258,
0.22331151366233826,
0.04497883468866348,
-0.04366642236709595,
0.006907598115503788,
-0.11201874911785126,
-0.016249148175120354,
0.30692577362060547,
-0.06537409126758575,
0.1463163048028946,
-0.10205362737178802,
0.06533724814653397,
-0.060949523001909256,
-0.026535384356975555,
0.13580892980098724,
-0.1328173279762268,
-0.10391727834939957,
-0.12501025199890137,
-0.2890404164791107,
0.17010360956192017,
-0.018657855689525604,
-0.1591114103794098,
-0.17833271622657776,
-0.07114963978528976,
-0.1275654137134552,
0.10268852859735489,
0.06822071969509125,
0.04316031187772751,
0.10889968276023865,
0.2917732894420624,
-0.15610067546367645,
0.11244300752878189,
0.06906455755233765,
0.11522453278303146,
0.23513129353523254,
0.0967700332403183,
-0.3017078638076782,
0.0053562503308057785,
-0.03848104178905487,
0.047695405781269073,
0.12987332046031952,
-0.04211902990937233,
0.298789381980896,
0.07058833539485931,
0.03880314156413078,
0.2972196936607361,
-0.07758933305740356,
0.020313657820224762,
-0.20064087212085724,
0.30848389863967896,
0.10288280248641968,
-0.03839991241693497,
-0.23260994255542755,
0.16190680861473083,
-0.006119003519415855,
0.10314806550741196,
0.031983502209186554,
0.035174574702978134,
-0.1368408054113388,
0.39369094371795654,
-0.01546509936451912,
0.09121440351009369,
0.11136840283870697,
0.06498154997825623,
-0.06056329235434532,
-0.08889802545309067,
0.027406716719269753,
-0.017028868198394775,
-0.20503613352775574,
0.21479415893554688,
-0.08006778359413147,
-0.053032487630844116,
0.17510099709033966,
0.18715780973434448,
-0.06745592504739761,
-0.11229487508535385,
0.05989357829093933,
-0.0974835529923439,
0.10690149664878845,
0.07503669708967209,
-0.05432462319731712,
-0.21366707980632782,
0.18724855780601501,
-0.11114206910133362,
0.24594934284687042,
-0.2533167600631714,
0.28292909264564514,
0.007798061240464449,
-0.34469297528266907,
-0.11462357640266418,
-0.04800330102443695,
0.07721763104200363,
0.028337813913822174,
-0.28106385469436646,
0.3138431906700134,
0.08256107568740845,
-0.11041527986526489,
0.049412403255701065,
-0.312195360660553,
0.05673002824187279,
-0.23742544651031494,
-0.07089492678642273,
0.09925952553749084,
-0.03326934948563576,
-0.015812862664461136,
0.0810248926281929,
0.24369625747203827,
0.12238594889640808,
0.08218861371278763,
-0.29630640149116516,
-0.17920996248722076,
-0.06874820590019226,
0.11776508390903473,
-0.03237154334783554,
0.0002125945466104895,
0.030162259936332703,
-0.2779328227043152,
-0.05909141153097153,
0.10231327265501022,
-0.1001976728439331,
0.13284093141555786,
0.037545349448919296,
-0.3676149845123291,
-0.06104733794927597,
0.07484827190637589,
-0.14140592515468597,
0.08144006133079529,
-0.035057131201028824,
0.10144910961389542,
0.35559356212615967,
-0.12813445925712585,
0.0048925080336630344,
-0.1298263669013977,
0.24665328860282898,
0.14636842906475067,
-0.015026967041194439,
0.1834462583065033,
0.2727266550064087,
0.18946705758571625,
-0.005753356497734785,
-0.14579090476036072,
-0.020827844738960266,
0.07657819986343384,
-0.18554949760437012,
0.12279754132032394,
-0.05980580300092697,
-0.07200335711240768,
0.07460734993219376,
-0.10843020677566528,
-0.12228307127952576,
0.1768168956041336,
0.009859117679297924,
0.054615672677755356,
-0.06279576569795609,
0.28162598609924316,
0.08753637224435806,
0.33814358711242676,
-0.14791783690452576,
0.2008659988641739,
0.02449931763112545,
-0.0791117399930954,
-0.04039452224969864,
-0.0757693201303482,
0.12473741918802261,
0.054782476276159286,
-0.013487707823514938,
-0.01564515009522438,
-0.0027046639006584883,
-0.13455647230148315,
0.04710913822054863,
0.037371810525655746,
-0.18728679418563843,
-0.046055495738983154,
-0.26606783270835876,
0.14658550918102264,
-0.10637710243463516,
0.058861181139945984,
0.11167474836111069,
0.1915491223335266,
-0.08281105011701584,
-0.13920237123966217,
-0.11830715090036392,
-0.011181659065186977,
-0.15651465952396393,
-0.01614336669445038,
0.03674294799566269,
-0.09650000184774399,
-0.3063908517360687,
-0.1669720709323883,
-0.03364783525466919,
-0.028940076008439064,
0.16426853835582733,
0.006710153538733721,
0.007384347263723612,
0.02428034134209156,
0.05363401770591736,
-0.02316763997077942,
0.02145560272037983,
-0.17568854987621307,
0.08499975502490997,
0.020264405757188797,
0.12482002377510071,
0.038664817810058594,
0.14616914093494415,
-0.04564962536096573,
-0.27619126439094543,
-0.016256023198366165,
0.12747888267040253,
0.14044684171676636
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. SummaryClinical characteristics.Prolidase deficiency is characterized by skin lesions (typically severe, chronic, recalcitrant, and painful skin ulcers of the lower extremities and telangiectasias of the face and hands), recurrent infections (particularly of the skin and respiratory tract), dysmorphic facial features, variable intellectual disability, and hepatomegaly with elevated liver enzymes and splenomegaly. Anemia, thrombocytopenia, hypergammaglobulinemia, and hypocomplementemia are common. An association between systemic lupus erythematosus (SLE) and prolidase deficiency has been described.Diagnosis/testing.The diagnosis of prolidase deficiency is established by detection of either biallelic PEPD pathogenic variants or reduced prolidase enzyme activity in a proband who has characteristic clinical findings and imidodipeptiduria.Management.Treatment of manifestations: No curative treatment is available. Supportive treatment of skin, lung, and immunologic manifestations has been efficacious in some (but not in all) patients. Caution is warranted in the treatment of infections, which | [
-0.16735124588012695,
0.1665227711200714,
0.06001921370625496,
-0.2699439227581024,
0.049820397049188614,
0.2522546648979187,
-0.018462631851434708,
-0.0389108881354332,
-0.09925640374422073,
-0.12300536781549454,
0.12135549634695053,
0.12034393846988678,
0.2569594383239746,
-0.06382247060537338,
-0.10824768990278244,
0.2579682469367981,
0.12346496433019638,
0.030460234731435776,
-0.08908180892467499,
0.005672633647918701,
0.012283745221793652,
-0.16898925602436066,
0.2784940302371979,
0.14351707696914673,
0.24051114916801453,
-0.054791975766420364,
0.019351666793227196,
0.03846455365419388,
-0.09190452843904495,
0.034821487963199615,
0.05143751949071884,
-0.12342896312475204,
-0.009592768736183643,
-0.17919933795928955,
0.07742609828710556,
-0.025185763835906982,
-0.07080487161874771,
-0.0213636327534914,
0.08929863572120667,
-0.04487992450594902,
-0.11853187531232834,
-0.021562503650784492,
0.07258378714323044,
0.11974269896745682,
0.08620277792215347,
-0.11349988728761673,
-0.051781732589006424,
0.19053411483764648,
-0.073079414665699,
0.1340842992067337,
0.2635037899017334,
-0.08150669932365417,
0.05771999806165695,
-0.1409647911787033,
0.22641101479530334,
0.042211856693029404,
0.10493945330381393,
0.07128927111625671,
-0.09849994629621506,
0.038144759833812714,
0.15115520358085632,
-0.03284424543380737,
-0.013154339976608753,
-0.25146856904029846,
0.24861860275268555,
-0.15400628745555878,
0.10912378877401352,
-0.179274320602417,
-0.2448166310787201,
-0.036889854818582535,
0.39559221267700195,
0.030117645859718323,
0.22450383007526398,
0.04651122912764549,
-0.13576632738113403,
-0.0978395864367485,
0.10815136879682541,
-0.04899533465504646,
0.007116225082427263,
-0.21173331141471863,
-0.09580692648887634,
0.27318239212036133,
-0.06841888278722763,
0.14003415405750275,
-0.03971877694129944,
0.34052544832229614,
0.18405549228191376,
0.04417678713798523,
0.2167338877916336,
-0.07498890906572342,
0.15338775515556335,
-0.25220760703086853,
0.09923776984214783,
-0.06207457184791565,
-0.07840944826602936,
-0.13694924116134644,
-0.006295725237578154,
-0.0763307735323906,
-0.0838305801153183,
0.06822705268859863,
0.12035699933767319,
0.1684802621603012,
0.007638456299901009,
0.07051233947277069,
0.09745568782091141,
-0.08114130049943924,
-0.22697149217128754,
-0.02804897539317608,
-0.12093111872673035,
0.06966166198253632,
0.2220664918422699,
0.03985040634870529,
-0.10517771542072296,
0.025002742186188698,
-0.1143055409193039,
-0.03644002974033356,
0.09122519195079803,
-0.0639752745628357,
-0.06004961207509041,
-0.17350418865680695,
-0.09424988180398941,
0.07786127179861069,
0.06020102649927139,
-0.18288487195968628,
0.3329094648361206,
0.09267333894968033,
0.08996178209781647,
0.06468674540519714,
0.12836812436580658,
-0.08369120210409164,
0.06119876727461815,
-0.1018776074051857,
-0.07950262725353241,
-0.19864216446876526,
-0.1309811919927597,
-0.0476626455783844,
-0.24734193086624146,
-0.11204957216978073,
-0.02925264649093151,
0.04084034636616707,
-0.028668062761425972,
-0.03715281933546066,
0.28342705965042114,
0.2234254628419876,
-0.13566522300243378,
0.17586012184619904,
0.40868237614631653,
0.06397632509469986,
0.019154565408825874,
0.05453826114535332,
0.04266077280044556,
-0.10545355081558228,
0.4422605037689209,
-0.012537221424281597,
-0.00220678374171257,
0.14149683713912964,
-0.23170237243175507,
0.04101014509797096,
-0.20195315778255463,
0.12567535042762756,
0.2323623150587082,
-0.11235508322715759,
0.21586085855960846,
-0.2527164816856384,
0.11886462569236755,
-0.016309956088662148,
-0.012055507861077785,
-0.1268012374639511,
0.14195303618907928,
0.07471705228090286,
0.037272095680236816,
-0.07435240596532822,
-0.08346664905548096,
0.10636714100837708,
0.28873926401138306,
-0.0851341113448143,
0.0776020735502243,
0.06636298447847366,
-0.041301578283309937,
-0.011972800828516483,
0.0046157208271324635,
-0.034675102680921555,
-0.14467473328113556,
-0.09048277139663696,
-0.019486872479319572,
-0.14440350234508514,
0.009342305362224579,
0.15763072669506073,
0.1198478564620018,
0.1040228009223938,
0.08939354121685028,
0.16683833301067352,
-0.031171847134828568,
-0.2213367223739624,
0.16999053955078125,
-0.21630284190177917,
0.08826573193073273,
-0.0016768128843978047,
-0.1328062117099762,
0.055238667875528336,
0.20241679251194,
-0.21373353898525238,
0.09537215530872345,
-0.01967637799680233,
-0.015487389639019966,
0.15213832259178162,
-0.08344551175832748,
-0.03442346304655075,
0.03450121358036995,
0.3992932438850403,
0.03668173775076866,
0.1785764843225479,
0.003800599602982402,
0.30435052514076233,
-0.05130060389637947,
-0.042922478169202805,
-0.3072803020477295,
0.0025240362156182528,
-0.12552012503147125,
0.013936394825577736,
-0.12738406658172607,
-0.06016116961836815,
-0.05810922756791115,
-0.24486224353313446,
0.04776506870985031,
0.008939593099057674,
-0.031074373051524162,
0.1148071363568306,
-0.0434604212641716,
0.008114897646009922,
-0.0875212550163269,
-0.038861457258462906,
0.19036956131458282,
0.1900879144668579,
-0.15144121646881104,
-0.20270326733589172,
-0.0271300058811903,
0.2338579148054123,
0.15421515703201294,
-0.10733422636985779,
-0.2585183084011078,
0.005279645789414644,
0.0056002079509198666,
-0.10034773498773575,
-0.20987778902053833,
0.07855027914047241,
-0.10594114661216736,
0.15592679381370544,
-0.05704812332987785,
0.08974852412939072,
0.011729691177606583,
-0.046804867684841156,
0.17670273780822754,
-0.08685735613107681,
-0.4825935959815979,
0.037672147154808044,
0.10529022663831711,
-0.119730144739151,
0.06837253272533417,
0.07875137776136398,
-0.0012662680819630623,
-0.0671711415052414,
0.19349521398544312,
0.13815683126449585,
0.06672214716672897,
0.002394826151430607,
-0.15326504409313202,
0.1508902758359909,
-0.1505730301141739,
-0.3143503665924072,
-0.022786403074860573,
0.10925433039665222,
0.20860496163368225,
0.13330957293510437,
-0.07503776252269745,
-0.11070243269205093,
-0.14945855736732483,
0.01820170134305954,
0.1606624275445938,
-0.20837724208831787,
0.15126724541187286,
-0.005664408672600985,
-0.14571034908294678,
-0.06739501655101776,
0.21544884145259857,
0.1509227603673935,
-0.022877678275108337,
0.2065851241350174,
0.08115791529417038,
0.11150803416967392,
0.10978186875581741,
0.10976677387952805,
-0.09255488216876984,
-0.05869366601109505,
-0.007009813096374273,
0.06315914541482925,
-0.09052379429340363,
-0.011596747674047947,
0.1115872710943222,
0.11202052980661392,
0.18047213554382324,
0.11559262126684189,
-0.09216507524251938,
-0.0392131581902504,
-0.07837703078985214,
-0.18419307470321655,
0.15311148762702942,
0.12585577368736267,
-0.13969655334949493,
0.12712687253952026,
-0.14989174902439117,
-0.05390783026814461,
0.013801982626318932,
-0.14878876507282257,
0.07189612090587616,
-0.052034441381692886,
-0.29305073618888855,
0.1151244044303894,
0.11743156611919403,
0.14608505368232727,
0.1913261115550995,
-0.15136931836605072,
0.11507578939199448,
0.22832641005516052,
-0.00782742165029049,
0.028470706194639206,
-0.13052131235599518,
-0.09696053713560104,
0.013082489371299744,
-0.09571383148431778,
-0.05307156220078468,
0.08065488189458847,
0.046308375895023346,
-0.020140577107667923,
-0.06375663727521896,
-0.019119393080472946,
0.26400667428970337,
-0.13034935295581818,
-0.11363548040390015,
-0.04431847110390663,
0.03644217923283577,
-0.07663069665431976,
-0.012266268022358418,
-0.13727642595767975,
-0.15261076390743256,
-0.023385243490338326,
0.09369153529405594,
-0.055733852088451385,
0.18442918360233307,
-0.019205579534173012,
-0.083414725959301,
-0.012658593244850636,
-0.08244214951992035,
-0.2244979292154312,
0.0749543160200119,
0.22124581038951874,
-0.05268867313861847,
-0.042809464037418365,
0.23121270537376404,
-0.1598554104566574,
-0.10360685735940933,
0.22707779705524445,
0.2819223403930664,
-0.2318629026412964,
0.2309139519929886,
0.14132478833198547,
-0.004209473263472319,
-0.02488398551940918,
0.07660181820392609,
0.0029826548416167498,
-0.028156990185379982,
-0.010445811785757542,
0.05677676573395729,
0.1266498565673828,
0.06306006014347076,
0.08908669650554657,
-0.31058263778686523,
0.14180003106594086,
-0.02993062138557434,
-0.11324162036180496,
-0.08452779054641724,
0.18033552169799805,
0.1117323562502861,
0.20813363790512085,
0.014081481844186783,
0.10873356461524963,
-0.24983009696006775,
0.14679352939128876,
-0.006324433721601963,
-0.09600379317998886,
0.24813729524612427,
0.17869561910629272,
0.05307643860578537,
0.10333053767681122,
-0.21314039826393127,
0.08174954354763031,
-0.09049612283706665,
-0.1287044882774353,
-0.18116743862628937,
0.06499245762825012,
0.044973284006118774,
-0.04010061174631119,
0.17822161316871643,
0.12548039853572845,
0.12277564406394958,
0.13972154259681702,
-0.05807620659470558,
0.1829877495765686,
0.19237051904201508,
-0.05847538635134697,
0.09314009547233582,
-0.008815182372927666,
-0.175912007689476,
-0.13072514533996582,
0.02980837970972061,
0.03719618171453476,
-0.1799943745136261,
0.12039604038000107,
0.25115758180618286,
-0.08165998011827469,
-0.21765848994255066,
-0.23055535554885864,
0.2507351040840149,
-0.0709146186709404,
-0.0716216191649437,
-0.059450533241033554,
-0.00698916707187891,
-0.09807488322257996,
0.05119512230157852,
0.13757260143756866,
0.15918874740600586,
0.1373172104358673,
-0.05477745458483696,
0.11717258393764496,
0.21170036494731903,
-0.09889185428619385,
0.1542530208826065,
0.10590086877346039,
0.2250560075044632,
0.0861222967505455,
0.19786018133163452,
-0.014391954056918621,
-0.21951423585414886,
-0.1344626545906067,
-0.10661850869655609,
0.15764790773391724,
-0.06128011271357536,
0.12390787899494171,
0.24296849966049194,
0.06834425777196884,
0.1593306064605713,
-0.158895805478096,
0.21107791364192963,
-0.08976557105779648,
-0.13135702908039093,
0.11776240170001984,
-0.1176934614777565,
-0.19649696350097656,
-0.06813584268093109,
0.022878747433423996,
0.07320961356163025,
0.15276063978672028,
-0.08948829770088196,
-0.1847383826971054,
0.1007959395647049,
0.2566344439983368,
-0.1947716325521469,
-0.010426041670143604,
0.09838730096817017,
0.03723922744393349,
0.29135197401046753,
0.1181529238820076,
0.11632341146469116,
0.025854192674160004,
-0.15514668822288513,
-0.09363878518342972,
0.007298503536731005,
0.06596689671278,
-0.0571657232940197,
0.09174063801765442,
-0.0720243752002716,
0.09895601868629456,
-0.2567165791988373,
0.022027719765901566,
0.05664721131324768,
-0.11730333417654037,
0.02476213499903679,
-0.06170301511883736,
0.15296854078769684,
0.024351196363568306,
0.10815989226102829,
0.06627524644136429,
0.012505472637712955,
0.29599612951278687,
0.19189302623271942,
-0.013385259546339512,
-0.1601257473230362,
-0.16089363396167755,
0.10938534140586853,
-0.07684191316366196,
0.08382488042116165,
-0.0656200721859932,
-0.005564806051552296,
0.2599722445011139,
0.16898958384990692,
-0.1419782042503357,
0.07876956462860107,
-0.2167210578918457,
0.07962601631879807,
0.16713294386863708,
0.2085537612438202,
-0.13095194101333618,
-0.20268110930919647,
-0.05002184212207794,
-0.04746762290596962,
-0.18073557317256927,
0.11661089211702347,
0.14609301090240479,
0.2755085825920105,
-0.03763413801789284,
0.14206208288669586,
-0.05569255352020264,
-0.009440883994102478,
0.15236295759677887,
-0.12016128748655319,
-0.2586970925331116,
0.04531761631369591,
0.04387521743774414,
-0.21819451451301575,
-0.3947828710079193,
-0.11847987771034241,
-0.1458572894334793,
-0.07670285552740097,
0.024167504161596298,
0.10729224234819412,
-0.029112406075000763,
-0.15105076134204865,
-0.06112189590930939,
0.07251447439193726,
-0.022110547870397568,
0.06364169716835022,
0.15381747484207153,
0.004956282675266266,
0.033562276512384415,
-0.17626406252384186,
0.1135907769203186,
-0.0702480897307396,
-0.03937836363911629,
0.0228156466037035,
0.0935278981924057,
0.009262359701097012,
0.09724695980548859,
-0.04446566104888916,
0.029072169214487076,
-0.08297158777713776,
-0.10304854810237885,
0.10014339536428452,
-0.1410212218761444,
-0.1266319751739502,
0.00031780105200596154,
-0.020377403125166893,
-0.01352133322507143,
-0.08059670031070709,
-0.050984855741262436,
-0.15286937355995178,
0.21772661805152893,
-0.057086631655693054,
0.05301849916577339,
-0.20259401202201843,
-0.052135732024908066,
-0.11692062020301819,
-0.047155868262052536,
0.029011480510234833,
-0.25146496295928955,
-0.21472790837287903,
-0.02851124294102192,
-0.17164340615272522,
-0.08138801902532578,
-0.12317297607660294,
0.10233177989721298,
-0.011491773650050163,
-0.07115894556045532,
0.06538117676973343,
0.11721983551979065,
-0.028562376275658607,
0.08289316296577454,
-0.1340344399213791,
0.08233330398797989,
0.11853829771280289,
-0.05467774346470833,
0.25406700372695923,
-0.1886288821697235,
-0.08210405707359314,
-0.0945214107632637,
0.21090391278266907,
-0.05117218941450119,
0.038153212517499924,
-0.2076374739408493,
-0.03788524121046066,
-0.13177791237831116,
-0.07791852951049805,
0.092738576233387,
-0.06017468124628067,
-0.25717437267303467,
0.007798332720994949,
0.19843916594982147,
0.15086491405963898,
-0.2660846710205078,
0.2200852930545807,
0.03645244240760803,
0.22481262683868408,
-0.07956277579069138,
0.08842672407627106,
0.014568704180419445,
0.21467213332653046,
-0.026042917743325233,
0.0012812198838219047,
-0.23147037625312805,
0.027607779949903488,
-0.26388347148895264,
0.11458830535411835,
0.0949675515294075,
0.14187070727348328,
-0.36248579621315,
-0.0875682532787323,
0.11164048314094543,
0.131845161318779,
0.014025276526808739,
0.06007322296500206,
0.06006677821278572,
0.05946195125579834,
-0.02676059678196907,
-0.09727279096841812,
0.015281041152775288,
-0.21791374683380127,
0.18923883140087128,
-0.05516103655099869,
0.4745042026042938,
0.06241385266184807,
-0.004263538401573896,
-0.09534027427434921,
-0.0658380538225174,
-0.12792134284973145,
0.13601158559322357,
-0.07615486532449722,
0.27030161023139954,
-0.09833457320928574,
0.03747494891285896,
0.0938650593161583,
-0.21615788340568542,
0.0862882137298584,
-0.05568721890449524,
-0.1855701208114624,
0.04129641130566597,
0.04835719242691994,
-0.010301056317985058,
0.1646265983581543,
-0.06876169145107269,
0.07582534104585648,
-0.1596575677394867,
0.15551671385765076,
-0.07932064682245255,
-0.09180149435997009,
0.12693756818771362,
0.044572021812200546,
0.022801561281085014,
0.17096035182476044,
-0.05327381566166878,
-0.08165943622589111,
-0.13483501970767975,
0.3087161183357239,
0.22805941104888916,
-0.1613224297761917,
-0.03494419902563095,
0.17259706556797028,
-0.09861181676387787,
-0.010549706406891346,
-0.141154482960701,
-0.13531450927257538,
0.16788364946842194,
0.040688224136829376,
-0.24386119842529297,
-0.1914735585451126,
-0.0257679782807827,
0.12769430875778198,
0.1509639322757721,
0.024223297834396362,
0.06483922898769379,
0.1031186580657959,
0.07427094131708145,
-0.04636026918888092,
-0.037818536162376404,
0.016933007165789604,
0.1867205947637558,
-0.18563607335090637,
-0.15902018547058105,
0.23325039446353912,
0.10145407170057297,
0.08711908757686615,
-0.07182403653860092,
0.0881711095571518,
-0.0414055697619915,
-0.05965451896190643,
0.11734993010759354,
0.1715981811285019,
0.07247880846261978,
0.20551593601703644,
-0.03491424769163132,
-0.18335500359535217,
0.008466719649732113,
0.13240280747413635,
-0.06418899446725845,
-0.10586411505937576,
0.16908061504364014,
-0.034221649169921875,
0.12502369284629822,
-0.16819928586483002,
-0.2557055950164795,
-0.0562887080013752,
0.19863243401050568,
-0.015754645690321922,
0.17344945669174194,
-0.03984164446592331,
-0.02250577323138714,
0.028363004326820374,
0.1522638499736786,
-0.08663760125637054,
0.12176182866096497,
0.33303049206733704,
-0.08088988810777664,
-0.18600602447986603,
-0.15298976004123688,
-0.16957537829875946,
0.17082224786281586,
-0.1356547772884369,
0.059077683836221695,
0.05201605707406998,
-0.06278688460588455,
-0.06895693391561508,
0.19895660877227783,
0.15380996465682983,
0.2464323490858078,
0.01169263944029808,
0.09082648903131485,
0.10834502428770065,
0.10413739085197449,
-0.1432182341814041,
-0.10124514997005463,
-0.09966065734624863,
-0.12659867107868195,
0.0016516842879354954,
0.11238953471183777,
0.02755001001060009,
0.10884090512990952,
-0.05476798862218857,
0.03151905536651611,
-0.21243824064731598,
-0.16322307288646698,
-0.050338014960289,
0.08984633535146713,
-0.20363715291023254,
-0.0776335597038269,
-0.14503727853298187,
-0.14466845989227295,
-0.024191919714212418,
0.0167507603764534,
-0.08000106364488602,
0.05121055990457535
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. SLE) and prolidase deficiency has been described.Diagnosis/testing.The diagnosis of prolidase deficiency is established by detection of either biallelic PEPD pathogenic variants or reduced prolidase enzyme activity in a proband who has characteristic clinical findings and imidodipeptiduria.Management.Treatment of manifestations: No curative treatment is available. Supportive treatment of skin, lung, and immunologic manifestations has been efficacious in some (but not in all) patients. Caution is warranted in the treatment of infections, which can be fulminant and fatal. Developmental and educational interventions as needed to address motor and cognitive delays.Prevention of secondary complications: Those who have undergone splenectomy should be appropriately immunized and treated promptly with antibiotics at the first sign of infection. Antibiotic prophylaxis should also be considered in the appropriate setting.Surveillance: In the absence of formal surveillance guidelines, the authors recommend annual: skin examination for evidence of malignant transformation in persons with chronic recalcitrant skin ulcers, complete blood count, liver function tests, | [
-0.10112916678190231,
0.17147992551326752,
-0.07581648230552673,
-0.2833479940891266,
0.06357286125421524,
0.19084620475769043,
0.026339560747146606,
-0.05142858624458313,
-0.06943716108798981,
-0.0997619703412056,
0.14818227291107178,
0.1283217966556549,
0.22355251014232635,
-0.10828197002410889,
-0.10916586965322495,
0.2342962920665741,
0.03359527513384819,
-0.00482771173119545,
-0.06558482348918915,
0.10466267168521881,
0.04546733573079109,
-0.20118267834186554,
0.27598103880882263,
0.08732575178146362,
0.19809263944625854,
0.01856308802962303,
0.04534108191728592,
-0.018971065059304237,
-0.03906551003456116,
-0.03962763771414757,
0.0017058429075405002,
-0.030878977850079536,
0.1049434021115303,
-0.10560892522335052,
-0.01576458103954792,
0.007745096459984779,
-0.09926202893257141,
-0.03647322207689285,
0.15737120807170868,
-0.0420035794377327,
-0.09367475658655167,
-0.07535508275032043,
0.08548882603645325,
0.12202389538288116,
0.004591085948050022,
-0.05335729569196701,
0.09555451571941376,
0.10073249787092209,
-0.1124572604894638,
0.09483953565359116,
0.0988318994641304,
-0.12408218532800674,
-0.03384484723210335,
-0.07725432515144348,
0.195683553814888,
0.12908488512039185,
0.007274999748915434,
0.029596548527479172,
-0.05590980499982834,
0.005721461493521929,
0.08709627389907837,
-0.04975114017724991,
0.016799408942461014,
-0.3310472369194031,
0.27499690651893616,
-0.003949828911572695,
0.07481233775615692,
-0.14213870465755463,
-0.135117307305336,
-0.0651153177022934,
0.4199197292327881,
0.06843716651201248,
0.21186627447605133,
0.009353598579764366,
-0.13741804659366608,
-0.026848532259464264,
0.10072120279073715,
-0.0722469687461853,
0.04445092752575874,
-0.2768290936946869,
-0.20548301935195923,
0.06212202087044716,
-0.08144096285104752,
0.13192741572856903,
-0.03963305801153183,
0.1696716845035553,
0.021511215716600418,
0.07459349185228348,
0.14971069991588593,
-0.0421360544860363,
0.1223493367433548,
-0.20680397748947144,
0.028302708640694618,
-0.04834083840250969,
-0.08059486001729965,
-0.25083523988723755,
-0.06864511221647263,
0.04662070423364639,
-0.017224984243512154,
0.16837453842163086,
0.10419376939535141,
0.1168927326798439,
0.04160261154174805,
0.07992754131555557,
0.1634865552186966,
-0.148898646235466,
-0.24793240427970886,
-0.04381658509373665,
-0.17323394119739532,
0.08661802858114243,
0.12141554802656174,
0.034156788140535355,
0.0025232096668332815,
-0.03296861797571182,
-0.11913321167230606,
-0.005746055394411087,
0.14295552670955658,
0.04586616903543472,
-0.038965433835983276,
-0.17281828820705414,
-0.054539065808057785,
-0.005742895416915417,
0.07194868475198746,
-0.10942070931196213,
0.3208370506763458,
0.049693889915943146,
0.04526321589946747,
-0.007000991143286228,
0.07221604883670807,
-0.068175308406353,
0.0576159805059433,
-0.1419312059879303,
-0.053704164922237396,
-0.24390769004821777,
-0.1733110547065735,
-0.05115858465433121,
-0.1635572910308838,
-0.02451048232614994,
-0.027963316068053246,
0.014625901356339455,
0.012142559513449669,
0.12029678374528885,
0.23696154356002808,
0.2744089961051941,
-0.15678556263446808,
0.1359613984823227,
0.32041215896606445,
0.11060567945241928,
0.11280891299247742,
0.005544940009713173,
0.044828664511442184,
-0.13002875447273254,
0.31973186135292053,
-0.04572543501853943,
0.02223721519112587,
0.10935407131910324,
-0.18293136358261108,
0.06764735281467438,
-0.23567524552345276,
0.025243934243917465,
0.14652119576931,
-0.07537063211202621,
0.17361603677272797,
-0.22835718095302582,
0.16072331368923187,
0.05159467086195946,
0.056774429976940155,
-0.013275147415697575,
0.050046827644109726,
0.002467874437570572,
0.029157249256968498,
0.018111273646354675,
-0.043986208736896515,
0.10427453368902206,
0.19689862430095673,
0.029879214242100716,
0.020508086308836937,
-0.025101864710450172,
-0.021498417481780052,
-0.02151261270046234,
-0.004781243856996298,
-0.06276612728834152,
-0.06705255806446075,
-0.08081620186567307,
-0.04396018385887146,
-0.20550045371055603,
-0.0008758796029724181,
0.13377021253108978,
0.11668139696121216,
0.15086284279823303,
0.1341584473848343,
0.11276257038116455,
-0.10939177870750427,
-0.21040846407413483,
0.1459842026233673,
-0.14273148775100708,
-0.00656481646001339,
0.07177332788705826,
-0.06622111052274704,
0.04561160132288933,
0.06745348125696182,
-0.13446836173534393,
0.13749149441719055,
-0.024884356185793877,
0.0474109910428524,
0.06432598829269409,
-0.05331144109368324,
0.013147257268428802,
0.07471775263547897,
0.2708737254142761,
-0.013314506970345974,
0.06280850619077682,
-0.045321349054574966,
0.18508554995059967,
-0.0744447410106659,
-0.013709669932723045,
-0.2572546601295471,
0.04003192484378815,
-0.1379019021987915,
0.029141593724489212,
-0.17408466339111328,
-0.06730187684297562,
-0.062214065343141556,
-0.19571468234062195,
0.01856435090303421,
-0.06764139980077744,
-0.06519931554794312,
0.07741241157054901,
-0.025372684001922607,
-0.050562188029289246,
-0.17570377886295319,
0.06352241337299347,
0.14758576452732086,
0.2016165554523468,
-0.1568198800086975,
-0.14323465526103973,
-0.05166471749544144,
0.2939152717590332,
0.10556469857692719,
-0.0710967481136322,
-0.10866402089595795,
0.07557529211044312,
0.20070572197437286,
-0.10332835465669632,
-0.16611994802951813,
0.070259690284729,
-0.004733334295451641,
0.17289787530899048,
-0.05725317820906639,
0.015886826440691948,
-0.07208604365587234,
-0.013747540302574635,
0.08672822266817093,
-0.05958733707666397,
-0.4732186198234558,
0.035003311932086945,
0.0892924889922142,
-0.029173163697123528,
0.04751179367303848,
-0.01777787320315838,
-0.05369419977068901,
-0.04783612862229347,
0.21500186622142792,
0.042501214891672134,
0.07696618884801865,
0.08482281863689423,
-0.11915422976016998,
0.073166124522686,
-0.07115791738033295,
-0.21234925091266632,
-0.07142120599746704,
0.04656679183244705,
0.17879174649715424,
0.042216911911964417,
-0.020705290138721466,
-0.00040840054862201214,
-0.2439984232187271,
0.00021414815273601562,
0.24001453816890717,
-0.22556358575820923,
0.15709349513053894,
0.1020507737994194,
-0.05275958776473999,
-0.0103974724188447,
0.04222626984119415,
0.14874127507209778,
0.05496395379304886,
0.23428642749786377,
0.04969803988933563,
0.11186936497688293,
0.09063481539487839,
0.12491703778505325,
-0.047771621495485306,
0.022981565445661545,
-0.029229450970888138,
0.144453763961792,
-0.20358996093273163,
-0.002229450037702918,
0.09473104774951935,
-0.0631444901227951,
0.1354467272758484,
0.15949195623397827,
-0.1672651618719101,
-0.012495973147451878,
-0.07951074838638306,
-0.14523731172084808,
0.10164648294448853,
0.1471107304096222,
-0.05966198071837425,
0.20341119170188904,
-0.10316518694162369,
-0.0627579614520073,
-0.05880352854728699,
-0.07366032898426056,
0.04039876163005829,
0.026059439405798912,
-0.2921237349510193,
0.10338835418224335,
0.07661901414394379,
0.14169305562973022,
0.2162506878376007,
-0.20258697867393494,
0.08082609623670578,
0.12275586277246475,
-0.007488057482987642,
0.030595330521464348,
-0.1403205543756485,
-0.0063346684910357,
0.05118732526898384,
-0.07575955986976624,
0.004238469060510397,
0.09566725790500641,
0.09258667379617691,
-0.03940645977854729,
0.0027324631810188293,
0.007643222808837891,
0.22936059534549713,
-0.12859447300434113,
-0.11632710695266724,
-0.013609223999083042,
-0.00339863495901227,
-0.09630948305130005,
0.03369415923953056,
-0.21232911944389343,
-0.20286229252815247,
-0.04807260259985924,
0.04887606203556061,
-0.011665022931993008,
0.13425128161907196,
0.022983793169260025,
-0.06467742472887039,
-0.06065928563475609,
-0.02025623619556427,
-0.2320990115404129,
0.19951246678829193,
0.22384662926197052,
0.06967643648386002,
-0.04288477078080177,
0.20682883262634277,
-0.11380569636821747,
-0.15213222801685333,
0.29912441968917847,
0.2624875605106354,
-0.14718681573867798,
0.2602412700653076,
0.15232713520526886,
0.026692744344472885,
-0.02647784724831581,
0.04318938031792641,
-0.03992674872279167,
0.020138109102845192,
0.04362037777900696,
0.12403799593448639,
0.010107495822012424,
-0.02688426896929741,
0.051658570766448975,
-0.21853841841220856,
0.16280369460582733,
-0.18935434520244598,
-0.16864816844463348,
-0.08191452920436859,
0.06655919551849365,
0.09338173270225525,
0.11040981113910675,
0.026753325015306473,
0.08661055564880371,
-0.18520542979240417,
0.08374433219432831,
-0.07727532088756561,
-0.10247401893138885,
0.26902613043785095,
0.23030905425548553,
0.03778449445962906,
0.09249550104141235,
-0.17538905143737793,
0.05614952743053436,
-0.02447003871202469,
-0.0925549864768982,
-0.20638149976730347,
0.03139836713671684,
0.08493243902921677,
-0.1601276397705078,
0.18229906260967255,
0.14073455333709717,
0.05591479316353798,
0.028317037969827652,
-0.05840343236923218,
0.07065796852111816,
0.04542960226535797,
-0.062424980103969574,
0.09550956636667252,
-0.03061993047595024,
-0.021371638402342796,
-0.12101712822914124,
0.06597410142421722,
-0.008787193335592747,
-0.23771899938583374,
0.10607228428125381,
0.21646513044834137,
-0.09731660038232803,
-0.08561264723539352,
-0.13961468636989594,
0.21239390969276428,
-0.050794534385204315,
-0.08168870955705643,
0.08745409548282623,
-0.02299264259636402,
-0.058727893978357315,
0.06396456062793732,
0.24904043972492218,
0.2871308922767639,
0.22978830337524414,
0.00857573002576828,
0.15598875284194946,
0.24358637630939484,
-0.07903750985860825,
0.07622092962265015,
0.07790236920118332,
0.22873567044734955,
-0.0013681206619367003,
0.18668010830879211,
0.09393417090177536,
-0.20080338418483734,
-0.041381243616342545,
-0.1133502945303917,
0.05046078935265541,
-0.04375413432717323,
0.1325005739927292,
0.2594849765300751,
-0.022656911984086037,
0.02875380590558052,
-0.06217210739850998,
0.15896786749362946,
-0.09702423959970474,
-0.09016501903533936,
0.12158416211605072,
-0.18377900123596191,
-0.10819210112094879,
-0.016925908625125885,
0.02540602907538414,
-0.055810000747442245,
0.1073276475071907,
-0.014877543784677982,
0.04398871958255768,
-0.03612712770700455,
0.21065233647823334,
-0.2163630872964859,
-0.0025602735113352537,
0.12041714042425156,
-0.003852692199870944,
0.13311706483364105,
-0.005532506853342056,
0.1172097846865654,
0.009405081160366535,
-0.10438603907823563,
-0.19148452579975128,
0.015511717647314072,
0.08277987688779831,
-0.07783277332782745,
0.1204199567437172,
0.03066994622349739,
0.043439313769340515,
-0.23046953976154327,
0.031089436262845993,
0.02578143961727619,
-0.12148408591747284,
-0.013182195834815502,
-0.03682262450456619,
0.09206811338663101,
-0.024379123002290726,
0.07302895188331604,
0.05557657405734062,
-0.04728265851736069,
0.29427996277809143,
0.1286131590604782,
-0.11757341027259827,
-0.11631825566291809,
-0.2727818489074707,
0.09900248050689697,
-0.07689207047224045,
0.06993639469146729,
-0.011940184980630875,
0.018700532615184784,
0.2731046974658966,
-0.0011783583322539926,
-0.08171618729829788,
0.05004126578569412,
-0.01732998713850975,
-0.006579997483640909,
0.14884112775325775,
0.1833944171667099,
0.00006415328243747354,
-0.21345944702625275,
-0.021389247849583626,
-0.18693499267101288,
-0.07378339767456055,
0.11538463085889816,
0.11390142142772675,
0.17025716602802277,
-0.13562063872814178,
0.2444949746131897,
0.05298471823334694,
0.07691249996423721,
0.23814013600349426,
0.00253192987293005,
-0.1733669936656952,
0.029871828854084015,
-0.016826171427965164,
-0.2222215235233307,
-0.36107784509658813,
-0.09826131910085678,
-0.2111276537179947,
-0.06416921317577362,
-0.040028009563684464,
0.07908455282449722,
0.0801500752568245,
-0.08599558472633362,
-0.03956703469157219,
-0.08453919738531113,
0.015427487902343273,
0.013511271215975285,
0.13399142026901245,
0.05058452859520912,
0.05113697424530983,
-0.2174302339553833,
0.1860276460647583,
0.004067057278007269,
-0.04135753586888313,
-0.0190871674567461,
0.049705248326063156,
0.07147997617721558,
0.13396631181240082,
-0.05952809378504753,
0.0803944319486618,
-0.060498710721731186,
-0.10337955504655838,
0.07145097106695175,
-0.1274549663066864,
-0.11571094393730164,
-0.04587950184941292,
-0.04785166680812836,
-0.14234593510627747,
-0.06134861335158348,
-0.03863256424665451,
-0.022903772071003914,
0.21368804574012756,
0.022761816158890724,
-0.0678480789065361,
-0.02778657339513302,
-0.06228986009955406,
-0.1444629728794098,
-0.03941818326711655,
0.05768182873725891,
-0.13996298611164093,
-0.09821700304746628,
0.0010509300045669079,
-0.05713150277733803,
-0.13269469141960144,
-0.11763919144868851,
0.08283723890781403,
-0.0803072527050972,
-0.09913883358240128,
0.0010899787303060293,
0.12151257693767548,
-0.024541009217500687,
0.05425254628062248,
-0.12159436196088791,
0.0313655324280262,
0.055352386087179184,
0.03343752771615982,
0.10869815200567245,
-0.1405402272939682,
-0.15332770347595215,
-0.13572244346141815,
0.18539485335350037,
0.010118999518454075,
0.13201665878295898,
-0.17362980544567108,
-0.10947877168655396,
-0.15885205566883087,
-0.22262704372406006,
0.16955478489398956,
-0.027343399822711945,
-0.2722080647945404,
-0.06073487922549248,
0.06863473355770111,
0.0868559330701828,
-0.2493468075990677,
0.17118366062641144,
0.03381279110908508,
0.11602496355772018,
-0.09155751019716263,
0.13034401834011078,
0.01841508410871029,
0.24040067195892334,
0.008292836137115955,
-0.10219407826662064,
-0.3261643946170807,
-0.00306527316570282,
-0.2919779419898987,
0.21248388290405273,
0.03276142477989197,
0.0595778152346611,
-0.18232369422912598,
0.02703850157558918,
0.05907833203673363,
0.027483101934194565,
0.04994764178991318,
-0.06460343301296234,
0.02616642788052559,
0.008822998031973839,
0.010440003126859665,
-0.1312706470489502,
0.012333961203694344,
-0.08543061465024948,
0.01665046438574791,
-0.03154873102903366,
0.2263660728931427,
-0.03274430334568024,
-0.037299178540706635,
-0.07069289684295654,
-0.04371143877506256,
-0.10430356860160828,
0.13836044073104858,
-0.09500321745872498,
0.19291295111179352,
-0.005701487883925438,
-0.10503797978162766,
0.11638589203357697,
-0.13581915199756622,
0.13439632952213287,
0.08152395486831665,
0.0017911909380927682,
0.044467877596616745,
-0.023334400728344917,
-0.03408372029662132,
0.07400590926408768,
-0.04447800666093826,
0.09800691902637482,
-0.28029632568359375,
0.20515058934688568,
-0.03907862305641174,
-0.06660949438810349,
0.08648771792650223,
0.08566602319478989,
0.033089496195316315,
0.1552421599626541,
-0.07148803025484085,
-0.014134702272713184,
0.02048102393746376,
0.1646268367767334,
0.12506771087646484,
-0.0718308836221695,
0.003924989607185125,
0.11214268952608109,
-0.050176169723272324,
0.003998038358986378,
-0.04786880314350128,
-0.19437052309513092,
0.1334684193134308,
-0.0014419693034142256,
-0.2678653299808502,
-0.1639685034751892,
-0.12823648750782013,
0.1308678537607193,
0.09566298872232437,
0.014922446571290493,
0.036638788878917694,
0.17631351947784424,
0.11081268638372421,
-0.08693914115428925,
-0.08848907053470612,
0.03322531655430794,
0.18637867271900177,
-0.11083222180604935,
-0.16792374849319458,
0.1753772348165512,
0.06635217368602753,
0.007312869653105736,
-0.10119935870170593,
0.11804083734750748,
-0.0890122577548027,
-0.03587299957871437,
0.08365286886692047,
0.11082002520561218,
-0.046725157648324966,
0.21784690022468567,
0.022641750052571297,
-0.008038260973989964,
-0.051304105669260025,
-0.06386224925518036,
-0.16513364017009735,
-0.04594091698527336,
0.11977164447307587,
-0.14204372465610504,
0.09796629101037979,
-0.14338013529777527,
-0.06598188728094101,
0.018193557858467102,
0.15527406334877014,
0.02577253058552742,
0.0792822390794754,
-0.10934468358755112,
0.025202209129929543,
0.09351227432489395,
0.0986223816871643,
-0.14228107035160065,
0.12962667644023895,
0.15718160569667816,
-0.07399541884660721,
-0.2514413297176361,
-0.2550533711910248,
-0.14119122922420502,
0.10884120315313339,
-0.09018116444349289,
0.060113683342933655,
-0.01762937568128109,
-0.13570135831832886,
-0.035055506974458694,
0.17944122850894928,
0.06914527714252472,
0.16233262419700623,
-0.015788769349455833,
0.06631123274564743,
0.13782881200313568,
0.08446435630321503,
-0.12798763811588287,
-0.13187728822231293,
-0.09171716123819351,
-0.18094345927238464,
0.06159915775060654,
-0.002373156137764454,
-0.04098943993449211,
0.03742709383368492,
-0.1250021904706955,
0.033191386610269547,
-0.15684843063354492,
-0.1925768405199051,
0.05332290381193161,
0.1409730464220047,
-0.11201953887939453,
-0.03177005052566528,
-0.09602540731430054,
-0.0018913174280896783,
0.012996572069823742,
-0.039395201951265335,
-0.08623115718364716,
0.038394078612327576
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. the treatment of infections, which can be fulminant and fatal. Developmental and educational interventions as needed to address motor and cognitive delays.Prevention of secondary complications: Those who have undergone splenectomy should be appropriately immunized and treated promptly with antibiotics at the first sign of infection. Antibiotic prophylaxis should also be considered in the appropriate setting.Surveillance: In the absence of formal surveillance guidelines, the authors recommend annual: skin examination for evidence of malignant transformation in persons with chronic recalcitrant skin ulcers, complete blood count, liver function tests, and abdominal ultrasound examination to assess the size of the liver and spleen. Follow up as recommended by a pulmonologist and immunologist. Follow-up assessments of motor and cognitive development as recommended for educational planning.Agents/circumstances to avoid: In those with splenomegaly: avoid contact sports given the increased risk for splenic rupture.Genetic counseling.Prolidase deficiency is inherited in an autosomal recessive manner. At conception, each sib of an affected individual has a 25% chance of being | [
-0.06585757434368134,
0.1699318140745163,
-0.07867458462715149,
-0.22173623740673065,
0.14770008623600006,
0.07871148735284805,
0.07605260610580444,
-0.1371326893568039,
-0.07254093885421753,
-0.13173624873161316,
0.1671406775712967,
0.17748375236988068,
0.0946626290678978,
-0.02389543317258358,
-0.2472558170557022,
0.12719078361988068,
0.08614268153905869,
-0.08620975911617279,
-0.10058807581663132,
0.21718449890613556,
0.12354643642902374,
-0.1764594316482544,
0.367632657289505,
0.038211528211832047,
0.22570335865020752,
0.0026383609510958195,
0.04288892820477486,
0.016525354236364365,
-0.1035289317369461,
0.076451875269413,
0.13101878762245178,
-0.07817145437002182,
0.00473279133439064,
-0.16616412997245789,
0.030372995883226395,
0.035098154097795486,
-0.1528189331293106,
-0.09562192112207413,
0.2959789037704468,
-0.04277034103870392,
-0.22573009133338928,
-0.1057635024189949,
0.06671081483364105,
0.06018764525651932,
0.06768056750297546,
-0.21611842513084412,
0.10414059460163116,
0.03403542935848236,
-0.16127759218215942,
0.10677230358123779,
0.1708652377128601,
-0.016923148185014725,
0.02239089086651802,
-0.0749562680721283,
0.18911302089691162,
0.06933856755495071,
-0.06218555569648743,
0.0969550684094429,
-0.02803034521639347,
0.0891767218708992,
0.15939472615718842,
-0.2616156041622162,
-0.04485977068543434,
-0.3530857264995575,
0.2298351675271988,
0.15369102358818054,
0.019690241664648056,
-0.16361083090305328,
-0.06264381855726242,
-0.14408007264137268,
0.41794446110725403,
0.1395079791545868,
0.13978919386863708,
0.0852963775396347,
-0.05490269139409065,
0.03255185857415199,
0.014911025762557983,
-0.1551646888256073,
0.13013125956058502,
-0.3639674186706543,
-0.2279023677110672,
0.0580504834651947,
-0.15238282084465027,
0.07839945703744888,
0.0025643666740506887,
0.11755318939685822,
0.03333757072687149,
0.20173798501491547,
0.07960736006498337,
0.06378781795501709,
-0.002217148430645466,
-0.11990376561880112,
0.05110306292772293,
0.006323554553091526,
-0.09759628772735596,
-0.22517113387584686,
-0.10467643290758133,
-0.018520774319767952,
-0.015901487320661545,
0.15133227407932281,
0.10050534456968307,
-0.0065284473821520805,
0.1629619002342224,
0.15374794602394104,
0.0680646225810051,
-0.16805815696716309,
-0.1609400361776352,
-0.025794317945837975,
-0.04751920327544212,
0.044018473476171494,
0.21429316699504852,
0.05317118391394615,
-0.02848612703382969,
-0.016030453145503998,
-0.11719813942909241,
0.0460604690015316,
0.1810322254896164,
0.050327274948358536,
-0.03923138231039047,
-0.15960992872714996,
-0.1118578314781189,
0.03915402665734291,
0.16704455018043518,
-0.14516474306583405,
0.2284577190876007,
0.06256052106618881,
0.08669683337211609,
-0.07713821530342102,
0.18434679508209229,
0.008399919606745243,
-0.03593006730079651,
-0.0003658733330667019,
-0.12304096668958664,
-0.1573401689529419,
-0.175587996840477,
-0.011471218429505825,
-0.2804599106311798,
-0.08809685707092285,
0.026323098689317703,
-0.10878711193799973,
-0.0030566358473151922,
-0.012107889167964458,
0.29368865489959717,
0.3417205810546875,
-0.1561557948589325,
0.1037888154387474,
0.35716959834098816,
0.13192428648471832,
-0.0022779987193644047,
-0.06716856360435486,
0.1405879110097885,
-0.15283644199371338,
0.3371296226978302,
-0.03807618096470833,
-0.10538320988416672,
0.02192438207566738,
-0.12343638390302658,
0.0866551622748375,
-0.15930941700935364,
-0.05476604029536247,
0.1269674152135849,
-0.03952421247959137,
0.06584621965885162,
-0.13043345510959625,
0.14780959486961365,
0.03381645679473877,
-0.024623004719614983,
-0.13767142593860626,
0.0706074982881546,
-0.004680928774178028,
-0.07768023759126663,
-0.03078744001686573,
0.015810806304216385,
-0.0012204935774207115,
0.11104466021060944,
-0.023943046107888222,
0.06859153509140015,
-0.006918266415596008,
0.061159662902355194,
-0.01817357912659645,
-0.09255606681108475,
-0.05307936295866966,
0.021919142454862595,
0.024327700957655907,
0.1158185601234436,
-0.29846930503845215,
0.04126347601413727,
0.25528573989868164,
0.04334494099020958,
0.1412360519170761,
0.10285360366106033,
0.0936223715543747,
-0.008139261044561863,
-0.2113424837589264,
0.12401912361383438,
-0.17071259021759033,
0.013475046493113041,
-0.03729161620140076,
-0.026083480566740036,
-0.040492527186870575,
0.03996462747454643,
-0.13774895668029785,
0.2250034362077713,
-0.08635485917329788,
-0.022210806608200073,
0.01410288643091917,
-0.024906300008296967,
0.14260272681713104,
-0.15628936886787415,
0.22138752043247223,
0.013802862726151943,
0.04669659584760666,
-0.04913840442895889,
0.1363925188779831,
-0.08855217695236206,
-0.017363594844937325,
-0.23269538581371307,
-0.03322450444102287,
-0.053784605115652084,
-0.08296346664428711,
-0.09381688386201859,
0.10986621677875519,
0.02530851401388645,
-0.22585922479629517,
-0.07484156638383865,
-0.048683423548936844,
0.03242551162838936,
-0.04076173156499863,
-0.046778883785009384,
-0.04551883041858673,
-0.10498769581317902,
0.15156938135623932,
0.026514122262597084,
0.10335411131381989,
-0.14745354652404785,
-0.049855977296829224,
0.04623059555888176,
0.37334150075912476,
0.12193670123815536,
0.0005042777047492564,
-0.1186530590057373,
0.19911639392375946,
0.17210526764392853,
-0.13905665278434753,
-0.16832886636257172,
0.08480186760425568,
0.028690949082374573,
0.09044265747070312,
-0.03808038681745529,
-0.11498097330331802,
-0.0425381101667881,
0.0914791077375412,
0.04057369381189346,
-0.09849435091018677,
-0.37505659461021423,
0.03340630233287811,
0.11330116540193558,
0.029140746220946312,
0.17018602788448334,
-0.11984250694513321,
0.01166848186403513,
-0.11758341640233994,
0.10742635279893875,
0.057819664478302,
0.11020340025424957,
0.07380667328834534,
-0.005842288490384817,
0.0815131887793541,
-0.0138621861115098,
-0.18621757626533508,
-0.11152253299951553,
0.05512671172618866,
0.07072217017412186,
0.0864444226026535,
-0.14857399463653564,
-0.07973726093769073,
-0.34797319769859314,
-0.007335012312978506,
0.30505338311195374,
-0.054428789764642715,
0.13613614439964294,
-0.050072357058525085,
-0.07574070990085602,
0.038201361894607544,
0.13741546869277954,
-0.01943468488752842,
0.0775732547044754,
0.09222058206796646,
-0.010369887575507164,
0.057553865015506744,
0.05717070400714874,
0.1646914780139923,
-0.0891495943069458,
0.005721664987504482,
0.021049397066235542,
0.11262450367212296,
-0.11470816284418106,
0.09882090240716934,
0.06696164608001709,
0.038578733801841736,
0.05597376078367233,
0.1904018074274063,
-0.06434457004070282,
-0.024938251823186874,
-0.06435181200504303,
-0.09285764396190643,
0.09990083426237106,
0.12351766973733902,
-0.14666004478931427,
0.29653242230415344,
-0.12451925128698349,
-0.03861580416560173,
-0.08096970617771149,
-0.07501320540904999,
-0.08063380420207977,
0.047875240445137024,
-0.279093474149704,
0.11891476809978485,
0.10653313249349594,
0.009087205864489079,
0.21286502480506897,
-0.11188671737909317,
0.09802279621362686,
0.17556270956993103,
0.035034190863370895,
0.0003622082294896245,
-0.0637928694486618,
0.1265377551317215,
0.10301363468170166,
-0.05992204323410988,
-0.05284775793552399,
0.05707651004195213,
0.04510237276554108,
-0.004484499339014292,
0.08960649371147156,
-0.07691850513219833,
0.35109400749206543,
-0.05782425403594971,
-0.07951689511537552,
-0.1263863742351532,
-0.00686502642929554,
0.0012366947485134006,
0.1393137276172638,
-0.27737483382225037,
-0.2103908509016037,
-0.0750054344534874,
0.13401909172534943,
-0.02257014811038971,
0.10737490653991699,
0.0005245071370154619,
-0.1457553654909134,
-0.1434297114610672,
0.04639698192477226,
-0.2365197092294693,
0.2168854922056198,
0.21935929358005524,
-0.027557436376810074,
0.04184480011463165,
0.3288320004940033,
-0.21552596986293793,
-0.13490787148475647,
0.10287798196077347,
0.2908410131931305,
-0.2190544456243515,
0.2633691430091858,
0.07814700901508331,
0.050975777208805084,
0.09784378111362457,
0.09887589514255524,
0.15310396254062653,
0.08000965416431427,
0.054341576993465424,
0.17087846994400024,
0.0752730667591095,
-0.09069260209798813,
-0.027129488065838814,
-0.270158976316452,
0.2703061103820801,
-0.14344653487205505,
-0.16613994538784027,
-0.07181490957736969,
-0.010961116291582584,
0.07580946385860443,
0.11154203861951828,
-0.0613463819026947,
0.1057974323630333,
-0.1670365184545517,
0.15297889709472656,
-0.052542682737112045,
-0.3252013325691223,
0.1318943202495575,
0.2676650285720825,
0.09914276003837585,
0.08725666999816895,
-0.1376631259918213,
0.06117207184433937,
0.10968159884214401,
-0.08296293765306473,
-0.10459860414266586,
0.06655987352132797,
0.004907337017357349,
-0.07786884903907776,
0.19808387756347656,
0.06006463244557381,
0.05505039170384407,
-0.07158757746219635,
-0.017637982964515686,
0.13399556279182434,
-0.07038858532905579,
-0.030005307868123055,
0.14551162719726562,
-0.009230535477399826,
0.04933665320277214,
-0.060678668320178986,
0.03760474547743797,
-0.10858724266290665,
-0.2175421118736267,
0.13395775854587555,
0.34764793515205383,
-0.08985303342342377,
-0.2358572781085968,
-0.22061260044574738,
0.20791809260845184,
-0.12321370095014572,
-0.07515113800764084,
0.08665316551923752,
-0.008970272727310658,
0.03142518177628517,
0.03466952592134476,
0.1457294374704361,
0.33470943570137024,
0.10037769377231598,
-0.03244459629058838,
0.03373650461435318,
0.1979846954345703,
0.004877547267824411,
0.11484381556510925,
0.11626087129116058,
0.197946235537529,
0.05399756506085396,
0.09752435237169266,
0.1251388043165207,
-0.247328519821167,
-0.04928379878401756,
-0.09407588094472885,
0.10393059998750687,
-0.002028566086664796,
0.0870203748345375,
-0.03596051037311554,
-0.08184833079576492,
-0.00003348099562572315,
-0.11186067759990692,
0.14281311631202698,
-0.0685519352555275,
-0.05283006653189659,
0.10336673259735107,
-0.0449901819229126,
0.08294383436441422,
-0.014480088837444782,
-0.09466084092855453,
-0.17519503831863403,
0.03006584569811821,
0.07582148164510727,
0.02329861745238304,
0.10760721564292908,
0.25828391313552856,
-0.18840597569942474,
-0.04308294132351875,
-0.0029887130949646235,
0.0023918398655951023,
0.18964870274066925,
0.007270164787769318,
0.007695595733821392,
0.12811331450939178,
-0.14492829144001007,
-0.1722068339586258,
0.13128376007080078,
0.06596627086400986,
-0.06811363995075226,
0.17364126443862915,
-0.06819358468055725,
0.10169681161642075,
-0.1316874474287033,
0.0771675556898117,
0.026924602687358856,
-0.008699176833033562,
-0.00191399862524122,
-0.09460798650979996,
0.23860765993595123,
-0.03732497990131378,
0.141137957572937,
-0.034866176545619965,
0.056814663112163544,
0.23614345490932465,
0.19708971679210663,
-0.1820421814918518,
-0.10444501787424088,
-0.22903947532176971,
0.12663353979587555,
-0.06517141312360764,
0.11789988726377487,
0.04214183986186981,
-0.0216458048671484,
0.20592832565307617,
0.01736670732498169,
0.015564153902232647,
-0.07873273640871048,
-0.022868402302265167,
0.07472976297140121,
0.187681645154953,
0.22739529609680176,
-0.0701763853430748,
-0.06599026173353195,
-0.022763803601264954,
-0.029608380049467087,
-0.1293051689863205,
0.18655526638031006,
0.1078154668211937,
0.08012330532073975,
-0.052657704800367355,
0.1699201911687851,
0.024662116542458534,
0.004737494979053736,
0.08175769448280334,
-0.02194940112531185,
-0.07111471146345139,
-0.10110823810100555,
0.05532216653227806,
-0.1270967274904251,
-0.4241326153278351,
-0.05980759114027023,
-0.28703591227531433,
-0.03541146218776703,
-0.06927996873855591,
0.06151627376675606,
-0.018741970881819725,
-0.08021722733974457,
0.08338628709316254,
-0.19167038798332214,
-0.11451876908540726,
-0.12144983559846878,
0.055036142468452454,
-0.012524737976491451,
0.0603632815182209,
-0.26080647110939026,
0.17066128551959991,
-0.034863851964473724,
-0.09715147316455841,
-0.041151631623506546,
0.0033065490424633026,
0.02535361796617508,
0.12952126562595367,
-0.007199043408036232,
0.058937668800354004,
-0.025599349290132523,
-0.09907457232475281,
0.027369290590286255,
-0.14778655767440796,
-0.17414648830890656,
-0.007900294847786427,
-0.09193749725818634,
-0.17942632734775543,
-0.04543681442737579,
-0.11805041879415512,
-0.044331517070531845,
0.10100054740905762,
-0.01948517933487892,
-0.07988613098859787,
0.07585511356592178,
-0.10468412190675735,
-0.12661921977996826,
-0.05068853497505188,
-0.08130842447280884,
-0.32153451442718506,
-0.10154987871646881,
0.04555541276931763,
-0.1338474601507187,
-0.20311880111694336,
-0.08180887252092361,
0.13501086831092834,
-0.11150256544351578,
-0.1833173930644989,
-0.021360941231250763,
0.07327482104301453,
-0.08847444504499435,
0.1389196366071701,
-0.09494368731975555,
0.06389464437961578,
0.07260699570178986,
-0.01505815889686346,
0.09204539656639099,
-0.12670284509658813,
-0.11591994762420654,
-0.08556528389453888,
0.2728897035121918,
0.029825691133737564,
0.037814781069755554,
-0.1136414110660553,
-0.09538428485393524,
-0.05600123479962349,
-0.25359785556793213,
0.21055422723293304,
0.025293229147791862,
-0.07991672307252884,
-0.03563958406448364,
0.06956900656223297,
0.05919237062335014,
-0.09147610515356064,
0.02158419042825699,
0.023215102031826973,
0.14956620335578918,
-0.19677887856960297,
0.13054688274860382,
0.04841849207878113,
0.17788738012313843,
0.03215048462152481,
-0.011922844685614109,
-0.23161491751670837,
-0.038294386118650436,
-0.18551908433437347,
0.2022547721862793,
0.050647441297769547,
0.09286324679851532,
-0.07326166331768036,
-0.011701690964400768,
0.04786698520183563,
0.05578212812542915,
0.07707123458385468,
-0.0621345117688179,
0.06435418128967285,
-0.09480312466621399,
0.04849042743444443,
0.025679806247353554,
-0.024816161021590233,
-0.06877337396144867,
-0.07338910549879074,
-0.003020744537934661,
0.22940903902053833,
0.06411729753017426,
-0.04568564146757126,
-0.021811140701174736,
-0.00014253401604946703,
-0.016199875622987747,
0.16675850749015808,
-0.11362764239311218,
0.0989043340086937,
0.03661446273326874,
-0.013801644556224346,
0.02901669777929783,
-0.09890800714492798,
0.16551591455936432,
0.13459710776805878,
0.10126550495624542,
0.06746873259544373,
-0.15440250933170319,
-0.11531855165958405,
-0.0064235348254442215,
-0.1406741738319397,
0.10574475675821304,
-0.17263181507587433,
0.06921718269586563,
-0.08171285688877106,
-0.011618423275649548,
0.17515303194522858,
0.08789689093828201,
0.018732789903879166,
0.1575334221124649,
-0.12293584644794464,
-0.10270209610462189,
0.022769231349229813,
0.24844983220100403,
0.028304846957325935,
-0.19592629373073578,
0.14033247530460358,
0.042024604976177216,
-0.04291042312979698,
-0.04946490749716759,
0.020998962223529816,
-0.2515599727630615,
0.05244527384638786,
0.07345208525657654,
-0.25843101739883423,
-0.13192550837993622,
-0.12830981612205505,
0.12453077733516693,
0.04139070585370064,
-0.13417208194732666,
0.07789535075426102,
0.09077401459217072,
-0.020303543657064438,
-0.06278109550476074,
-0.1984403133392334,
0.16184493899345398,
0.2370435744524002,
-0.1276773065328598,
-0.09142063558101654,
0.04009728133678436,
0.011267974972724915,
-0.04199943318963051,
-0.08986743539571762,
0.0720638558268547,
-0.07415799796581268,
0.025897450745105743,
0.18974031507968903,
0.08358943462371826,
-0.17930586636066437,
0.27090296149253845,
-0.0586407370865345,
-0.03700564056634903,
0.04100137948989868,
-0.079793781042099,
-0.05262661352753639,
-0.14340806007385254,
0.11836601793766022,
-0.06713072955608368,
0.03753386437892914,
-0.19381467998027802,
0.034606002271175385,
0.05471732094883919,
0.06439672410488129,
0.08314049243927002,
0.15675905346870422,
-0.0890028327703476,
-0.06737443804740906,
0.153939351439476,
0.05262378603219986,
-0.029817253351211548,
0.04786066710948944,
0.1564970314502716,
-0.0534445159137249,
-0.2568713128566742,
-0.23472841084003448,
-0.2161533236503601,
0.19454798102378845,
-0.0282504353672266,
0.06384239345788956,
0.024009473621845245,
-0.010371961630880833,
-0.020601583644747734,
0.2347402125597,
0.06257016211748123,
0.2512889802455902,
-0.006071944255381823,
-0.04518112167716026,
0.24198438227176666,
0.09961660206317902,
-0.050314027816057205,
-0.0976477712392807,
-0.19408905506134033,
-0.27369803190231323,
0.09527935832738876,
-0.008861731737852097,
-0.1044696718454361,
0.021270157769322395,
-0.1339869499206543,
0.10274740308523178,
-0.03104826807975769,
-0.1764628142118454,
0.06466832011938095,
0.03479311615228653,
-0.10265342146158218,
0.03295315057039261,
-0.014479142613708973,
0.01684376783668995,
0.025913015007972717,
-0.04554492235183716,
-0.0758623406291008,
-0.003649958176538348
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. count, liver function tests, and abdominal ultrasound examination to assess the size of the liver and spleen. Follow up as recommended by a pulmonologist and immunologist. Follow-up assessments of motor and cognitive development as recommended for educational planning.Agents/circumstances to avoid: In those with splenomegaly: avoid contact sports given the increased risk for splenic rupture.Genetic counseling.Prolidase deficiency is inherited in an autosomal recessive manner. At conception, each sib of an affected individual has a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier. Carrier testing for at-risk relatives and prenatal testing for pregnancies at increased risk are possible if the PEPD pathogenic variants in the family have been identified.DiagnosisNo formal diagnostic criteria or testing algorithms for prolidase deficiency have been published.Suggestive FindingsProlidase deficiency should be suspected in individuals with the following clinical, laboratory, and biochemical findings. | [
-0.1843683421611786,
0.15078459680080414,
0.029164845123887062,
-0.22045348584651947,
0.13007238507270813,
0.12846748530864716,
0.022161871194839478,
-0.052726052701473236,
-0.09484677016735077,
-0.11390768736600876,
0.13173535466194153,
0.26522505283355713,
0.10385064780712128,
-0.028571445494890213,
-0.05011420324444771,
0.04208379611372948,
0.010948514565825462,
0.01404548715800047,
-0.024852070957422256,
0.1523422747850418,
-0.061900340020656586,
-0.16752301156520844,
0.3403051495552063,
0.1514071822166443,
0.19724826514720917,
-0.03493713587522507,
0.06138773635029793,
-0.11620167642831802,
-0.0732467770576477,
0.1700626015663147,
0.21965932846069336,
-0.09053861349821091,
-0.0561961755156517,
-0.12143582850694656,
-0.0452452227473259,
-0.01444237306714058,
-0.1227601021528244,
0.053151290863752365,
0.2684159278869629,
-0.07275502383708954,
-0.21723322570323944,
-0.028625255450606346,
0.09432480484247208,
0.11055270582437515,
0.08051976561546326,
-0.3615429699420929,
0.13654278218746185,
-0.019697697833180428,
-0.07389694452285767,
0.12874215841293335,
0.2422073930501938,
-0.16897349059581757,
-0.04505648836493492,
-0.11176863312721252,
0.36443981528282166,
0.17498454451560974,
0.035453520715236664,
0.13717129826545715,
-0.05443381890654564,
0.06201311945915222,
0.08039356768131256,
-0.2602322995662689,
-0.13207995891571045,
-0.3394324779510498,
0.22432975471019745,
-0.10314120352268219,
0.14954473078250885,
-0.201571986079216,
-0.0013926646206527948,
-0.05136067047715187,
0.3647467792034149,
0.05468151345849037,
0.20818667113780975,
0.05920293927192688,
0.0005723243812099099,
0.13394293189048767,
-0.06490188091993332,
-0.2182701826095581,
0.020876044407486916,
-0.269085556268692,
-0.06457038223743439,
0.026691632345318794,
-0.0474044494330883,
0.15034131705760956,
-0.05099776014685631,
0.15777331590652466,
0.17520226538181305,
0.1448557823896408,
0.16221556067466736,
0.02243499644100666,
-0.03332415595650673,
-0.17488503456115723,
0.2235794961452484,
-0.12107732892036438,
-0.0689149796962738,
-0.10429868847131729,
-0.11935016512870789,
0.04617183282971382,
-0.04050254821777344,
0.19260497391223907,
0.05531339719891548,
-0.054369259625673294,
0.12670990824699402,
0.18363884091377258,
0.26196032762527466,
-0.2292957603931427,
-0.3041105270385742,
-0.0164134930819273,
-0.09924852848052979,
0.03755679726600647,
0.19819724559783936,
0.010261300951242447,
-0.15852302312850952,
-0.11413490027189255,
-0.10387548804283142,
-0.03342078998684883,
0.0889504924416542,
0.03928688168525696,
-0.13717205822467804,
-0.17440399527549744,
0.04352135583758354,
0.05125685781240463,
0.14367151260375977,
-0.12985505163669586,
-0.012746798805892467,
0.12453140318393707,
0.028119372203946114,
0.08666452765464783,
0.22213900089263916,
0.09069779515266418,
0.07140640169382095,
0.026851125061511993,
-0.0923786461353302,
-0.0854601114988327,
-0.10665570944547653,
-0.142957404255867,
-0.28993815183639526,
-0.04826175048947334,
-0.07462725788354874,
-0.12622322142124176,
0.027777209877967834,
0.02244240790605545,
0.20196089148521423,
0.30214542150497437,
-0.0648295134305954,
-0.0001090893056243658,
0.33788666129112244,
0.10407127439975739,
0.09834442287683487,
-0.01911766082048416,
0.22016124427318573,
-0.12346618622541428,
0.37451496720314026,
0.08706945925951004,
-0.15175867080688477,
-0.1002916544675827,
-0.11813522130250931,
0.044614579528570175,
-0.2003093808889389,
-0.005115972366183996,
0.279588907957077,
-0.06515658646821976,
0.11658383905887604,
-0.09306052327156067,
0.20241035521030426,
-0.21772252023220062,
-0.03997733071446419,
-0.1326194554567337,
0.08993599563837051,
-0.027633177116513252,
-0.11004103720188141,
0.0021408218890428543,
0.015543405897915363,
-0.09020067751407623,
0.077351413667202,
0.063667431473732,
0.017575716599822044,
-0.014401883818209171,
-0.00726938433945179,
-0.17083317041397095,
-0.062136534601449966,
-0.08644209057092667,
0.013276795856654644,
-0.10231587290763855,
0.029035452753305435,
-0.1953129768371582,
0.10029269754886627,
0.2686092257499695,
-0.03332538157701492,
0.25327545404434204,
0.10905109345912933,
0.13445334136486053,
0.08059296756982803,
-0.15488986670970917,
0.04705928638577461,
-0.19423794746398926,
0.13673484325408936,
0.1785622537136078,
-0.09885305166244507,
-0.16448090970516205,
0.06701257824897766,
-0.09925506263971329,
0.2340468019247055,
0.03217431530356407,
0.025420086458325386,
0.03448373079299927,
-0.0632598027586937,
0.08927112072706223,
-0.21303658187389374,
0.2870433032512665,
0.033129170536994934,
0.01675204001367092,
0.004617458209395409,
0.0763239935040474,
-0.0875251442193985,
-0.040951382368803024,
-0.24360573291778564,
-0.0707380473613739,
0.06604516506195068,
-0.17067758738994598,
-0.07718148082494736,
0.012623526155948639,
0.1497756689786911,
-0.22168345749378204,
-0.009962583892047405,
0.05756465718150139,
-0.05770598351955414,
0.01996690407395363,
0.06280231475830078,
-0.08490053564310074,
0.0007277033873833716,
0.09510300308465958,
0.07727795839309692,
0.17336370050907135,
-0.16594918072223663,
-0.05311531201004982,
0.016842186450958252,
0.25977250933647156,
0.19129841029644012,
-0.07636972516775131,
-0.24305014312267303,
0.15147903561592102,
0.1379171907901764,
-0.13221792876720428,
-0.045539747923612595,
0.026849426329135895,
-0.04279020056128502,
0.054484616965055466,
-0.028752850368618965,
-0.060329318046569824,
-0.09173739701509476,
0.10791720449924469,
0.19254808127880096,
-0.06197527423501015,
-0.3116464912891388,
0.03729021176695824,
0.08763892948627472,
0.06777539104223251,
0.08647320419549942,
0.031845688819885254,
0.07016551494598389,
-0.01954714208841324,
0.01586083695292473,
0.18491530418395996,
0.08469364047050476,
-0.019643204286694527,
-0.17132507264614105,
0.025621715933084488,
-0.032398615032434464,
-0.2982092797756195,
-0.07516470551490784,
0.03204473853111267,
0.13240158557891846,
0.10355895757675171,
-0.16249625384807587,
-0.056934814900159836,
-0.24854208528995514,
0.012759190984070301,
0.30074045062065125,
-0.15513363480567932,
-0.060508862137794495,
-0.08128110319375992,
-0.11944493651390076,
0.01749754510819912,
0.12107105553150177,
-0.00796748511493206,
0.14528223872184753,
-0.0735582560300827,
-0.031916793435811996,
-0.022067496553063393,
0.07341457903385162,
0.09207050502300262,
-0.21549439430236816,
0.014432169497013092,
0.10952690988779068,
0.14319413900375366,
-0.15302744507789612,
0.010341967456042767,
0.10192444175481796,
0.13849776983261108,
0.06988849490880966,
0.10798250138759613,
0.05293585732579231,
-0.06449190527200699,
-0.028259871527552605,
0.00036954061943106353,
0.01175018586218357,
0.1734832227230072,
-0.16827459633350372,
0.33895766735076904,
-0.2343538999557495,
-0.09031405299901962,
-0.1432080864906311,
-0.13258354365825653,
0.059417013078927994,
0.017589464783668518,
-0.32187163829803467,
0.20448391139507294,
0.1454765945672989,
0.1815357655286789,
0.16911377012729645,
-0.0027592803817242384,
-0.03688076511025429,
0.2951280474662781,
-0.15604691207408905,
-0.08275426179170609,
-0.061415668576955795,
0.11915408074855804,
0.12504439055919647,
0.020892273634672165,
-0.01680789887905121,
0.087772436439991,
0.044657204300165176,
-0.01110125333070755,
0.12246235460042953,
-0.045308660715818405,
0.35838717222213745,
-0.1157270073890686,
-0.0680285394191742,
0.03466473147273064,
-0.06866846233606339,
0.10529747605323792,
0.021269874647259712,
-0.024554511532187462,
-0.1424616426229477,
-0.07538056373596191,
0.10433785617351532,
-0.08555582165718079,
0.09212791174650192,
-0.01311767753213644,
-0.24906766414642334,
0.07950178533792496,
-0.06010252982378006,
-0.1431730091571808,
0.13732804358005524,
0.1568465232849121,
-0.01916983723640442,
0.08329273760318756,
0.2715030610561371,
-0.14704753458499908,
-0.14513947069644928,
0.04881061986088753,
0.2234581857919693,
-0.20254172384738922,
0.12746836245059967,
0.05022624880075455,
0.1777336448431015,
0.07795783132314682,
0.17255961894989014,
0.09149113297462463,
0.09177325665950775,
0.0735967829823494,
0.1543399691581726,
0.10536272823810577,
-0.03814394026994705,
-0.01937485672533512,
-0.25915858149528503,
0.15089015662670135,
-0.09421356767416,
-0.15219731628894806,
-0.016597136855125427,
0.044361140578985214,
0.08925076574087143,
0.17970982193946838,
-0.03929895907640457,
0.11081746965646744,
-0.0316336415708065,
0.15175913274288177,
0.06490151584148407,
-0.37269553542137146,
0.15211574733257294,
0.1715998500585556,
-0.0314779095351696,
0.053222186863422394,
-0.2004043608903885,
0.05752649903297424,
0.10359293967485428,
-0.1099943295121193,
-0.0814567506313324,
0.09901837259531021,
-0.12304108589887619,
-0.08965767920017242,
0.14198729395866394,
0.07326821237802505,
0.015702353790402412,
-0.07019604742527008,
-0.09024239331483841,
0.23103034496307373,
0.14763392508029938,
-0.07355640828609467,
0.2729833722114563,
0.011286979541182518,
-0.0764245092868805,
-0.08460686355829239,
0.00655421894043684,
0.057264409959316254,
-0.22405195236206055,
0.08693896234035492,
0.30645880103111267,
-0.05652569234371185,
-0.1338459551334381,
-0.07661394029855728,
0.19585800170898438,
-0.12661528587341309,
-0.0471116341650486,
-0.14109738171100616,
0.09970811754465103,
0.003947790712118149,
0.015442010946571827,
0.2088259607553482,
0.23225195705890656,
0.06411633640527725,
-0.1039278656244278,
-0.05040265992283821,
0.12133095413446426,
0.12909956276416779,
0.1758090853691101,
0.1162494346499443,
0.21279436349868774,
0.09171508252620697,
0.079270139336586,
0.21471047401428223,
-0.2970343828201294,
-0.1360008269548416,
-0.07647938281297684,
0.24011757969856262,
0.14952565729618073,
0.009852012619376183,
0.051756251603364944,
-0.024079211056232452,
0.01227988675236702,
-0.145285502076149,
0.004944340325891972,
-0.06788890063762665,
-0.03474247083067894,
0.2524745762348175,
-0.010695830918848515,
0.060631465166807175,
-0.07971864938735962,
-0.08510564267635345,
-0.1108352467417717,
0.22428861260414124,
0.0511305034160614,
-0.16401049494743347,
0.08429960161447525,
0.0653320774435997,
-0.21593128144741058,
0.0005210579838603735,
0.1176084652543068,
-0.032118771225214005,
0.25913435220718384,
0.08104982227087021,
-0.006043261382728815,
-0.0141742629930377,
-0.055486924946308136,
-0.053776275366544724,
0.08818022906780243,
0.03281788155436516,
-0.03677069768309593,
0.1620706468820572,
-0.02136794477701187,
0.06041622534394264,
-0.11813349276781082,
0.0005269776447676122,
0.005075268913060427,
-0.0803498849272728,
-0.0557284951210022,
-0.23410539329051971,
0.20616687834262848,
0.11018219590187073,
0.02024516649544239,
0.07397595793008804,
0.11591160297393799,
0.2226659655570984,
0.029141338542103767,
-0.3693835735321045,
-0.04730270057916641,
-0.21438626945018768,
-0.05806412175297737,
0.049430590122938156,
-0.009691021405160427,
0.0370120033621788,
0.0869532898068428,
0.2993502914905548,
-0.08569405972957611,
-0.09607197344303131,
-0.14866946637630463,
-0.09327679872512817,
0.08376134932041168,
0.3018063008785248,
0.26351794600486755,
-0.1397928148508072,
-0.07058385759592056,
-0.021067732945084572,
0.05320928618311882,
-0.29133397340774536,
0.03931717947125435,
0.17681388556957245,
0.027616258710622787,
-0.054488375782966614,
0.1432458758354187,
-0.005234960466623306,
0.020421065390110016,
0.06839766353368759,
0.009439635090529919,
0.01616780273616314,
-0.08168379962444305,
0.10728238523006439,
-0.0970955416560173,
-0.47233346104621887,
-0.09824158251285553,
-0.2709362506866455,
-0.06612030416727066,
-0.053390324115753174,
0.036269187927246094,
-0.038056399673223495,
-0.04428911581635475,
-0.007582535035908222,
-0.13027670979499817,
-0.10249573737382889,
-0.058640532195568085,
0.008459018543362617,
0.01858346164226532,
-0.07024212926626205,
-0.20287473499774933,
0.13975632190704346,
-0.03560928255319595,
-0.14112943410873413,
-0.018229734152555466,
-0.0024663228541612625,
-0.021694088354706764,
0.0702667161822319,
-0.04455822706222534,
0.009862455539405346,
-0.07109896093606949,
-0.085378497838974,
-0.009695827029645443,
-0.12132824957370758,
-0.15025706589221954,
0.0820993110537529,
-0.06169625744223595,
-0.2370574027299881,
-0.12354284524917603,
-0.21472594141960144,
-0.053091373294591904,
0.13535578548908234,
0.10547219216823578,
-0.06739150732755661,
0.07970380783081055,
-0.05154210701584816,
-0.15874625742435455,
0.034255120903253555,
-0.10948335379362106,
-0.23177990317344666,
-0.1432909369468689,
0.14786846935749054,
-0.21696814894676208,
-0.17711341381072998,
-0.1391085535287857,
0.12807714939117432,
-0.04218178614974022,
-0.14660485088825226,
-0.11656854301691055,
0.15113478899002075,
-0.04628369212150574,
0.18506675958633423,
-0.046335991472005844,
0.0024304725229740143,
0.10178752988576889,
-0.07261813431978226,
0.06102776527404785,
-0.16941288113594055,
-0.028845172375440598,
-0.09483025968074799,
0.24252119660377502,
-0.09702019393444061,
0.026071807369589806,
-0.07405458390712738,
-0.0594203807413578,
-0.09957116842269897,
-0.32730379700660706,
0.28896835446357727,
-0.06918376684188843,
-0.17970547080039978,
0.055960435420274734,
0.017168067395687103,
0.07971032708883286,
-0.16239537298679352,
0.1532222032546997,
0.02747536078095436,
0.12061390280723572,
-0.23331566154956818,
0.0816086083650589,
0.0316568948328495,
0.14244790375232697,
0.045579828321933746,
0.016301680356264114,
-0.15135051310062408,
-0.028096836060285568,
-0.20337477326393127,
0.2161155790090561,
0.12179893255233765,
0.10949070006608963,
-0.06586635857820511,
-0.019631097093224525,
0.1381489485502243,
0.08981754630804062,
-0.05068392679095268,
0.018734294921159744,
0.1520845741033554,
-0.23763057589530945,
-0.03600529953837395,
-0.056444939225912094,
-0.01707261987030506,
-0.1422000378370285,
0.045002181082963943,
0.00945662334561348,
0.18852615356445312,
0.08682140707969666,
-0.15562225878238678,
0.020760152488946915,
-0.0025487125385552645,
-0.014954984188079834,
0.2265634834766388,
-0.11883511394262314,
0.17944738268852234,
-0.04135579243302345,
0.015717867761850357,
-0.06676501035690308,
-0.05721115693449974,
0.11279964447021484,
0.06689094007015228,
-0.09503131359815598,
0.21447990834712982,
-0.07819927483797073,
-0.04748327657580376,
0.01530100591480732,
-0.17586655914783478,
0.13887523114681244,
-0.04098767042160034,
0.032921455800533295,
0.0003539647732395679,
-0.025027090683579445,
0.07969529926776886,
0.008626462891697884,
-0.05669138580560684,
0.11193891614675522,
-0.014560476876795292,
-0.005189082119613886,
-0.15914402902126312,
0.257062703371048,
0.16289635002613068,
-0.048104483634233475,
0.11756570637226105,
0.13128267228603363,
-0.13706941902637482,
-0.09473726153373718,
0.050892796367406845,
-0.14921435713768005,
0.16053873300552368,
0.06519070267677307,
-0.18423782289028168,
-0.07764790952205658,
-0.14848944544792175,
0.09394770115613937,
0.16683252155780792,
-0.047051429748535156,
0.05293659120798111,
0.07708393782377243,
0.03573977202177048,
0.0162197332829237,
-0.23517663776874542,
0.16625656187534332,
0.33494535088539124,
-0.13619545102119446,
-0.024562319740653038,
0.07698684185743332,
0.1312250792980194,
-0.085797518491745,
-0.1277792602777481,
0.1421138048171997,
0.003062331583350897,
0.09758448600769043,
0.17685383558273315,
0.05793200433254242,
-0.04529236629605293,
0.23325511813163757,
-0.008096575736999512,
-0.18117040395736694,
0.015544871799647808,
0.01650547794997692,
-0.08676045387983322,
-0.029284145683050156,
0.16774436831474304,
-0.20494551956653595,
0.09094756096601486,
-0.2619277238845825,
0.04525648429989815,
0.02615460380911827,
0.06716956943273544,
0.044572580605745316,
0.16939379274845123,
-0.004301981069147587,
-0.26440560817718506,
0.1329594999551773,
0.12927193939685822,
-0.07471245527267456,
0.01820068061351776,
0.24790255725383759,
0.05232464149594307,
-0.10389105975627899,
-0.1971147209405899,
-0.2157219797372818,
0.18514852225780487,
-0.17723822593688965,
0.08931946754455566,
0.012400684878230095,
0.15861889719963074,
0.07554259896278381,
0.1763046383857727,
0.034652382135391235,
0.18752223253250122,
-0.04372498393058777,
-0.048095814883708954,
0.12855905294418335,
0.05506089702248573,
-0.07060076296329498,
-0.07211531698703766,
-0.20359481871128082,
-0.10186909139156342,
0.0951775535941124,
0.056653942912817,
-0.011542296037077904,
-0.019314438104629517,
-0.1188126802444458,
0.24691267311573029,
0.004215468652546406,
-0.1199009120464325,
0.016224732622504234,
-0.021836554631590843,
-0.1341453492641449,
0.044120047241449356,
-0.05410193279385567,
0.00540491146966815,
-0.03743633255362511,
-0.0953373834490776,
-0.03423690423369408,
0.06560266762971878
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier. Carrier testing for at-risk relatives and prenatal testing for pregnancies at increased risk are possible if the PEPD pathogenic variants in the family have been identified.DiagnosisNo formal diagnostic criteria or testing algorithms for prolidase deficiency have been published.Suggestive FindingsProlidase deficiency should be suspected in individuals with the following clinical, laboratory, and biochemical findings.ClinicalSkin lesions, typically lower extremity ulcers. Other lesions such as telangiectasias of the face and hands are also common .Recurrent infections, particularly of the skin and respiratory tract Chronic lung disease with digital clubbing and a cystic fibrosis-like phenotype Dysmorphic facial features, including widely spaced eyes, proptosis, depressed nasal bridge, prognathism, thin vermilion of the upper lip, and low anterior and posterior hairline Developmental delay of variable degree Splenomegaly Systemic | [
-0.1798793226480484,
0.20313559472560883,
0.09623021632432938,
-0.21686550974845886,
0.14810620248317719,
0.13857439160346985,
0.04148314520716667,
0.01159291435033083,
-0.1812966912984848,
-0.20740677416324615,
0.11671261489391327,
0.11294523626565933,
0.2889407277107239,
0.044435855001211166,
-0.19030630588531494,
0.14463156461715698,
0.10317631810903549,
-0.022854210808873177,
-0.04783454164862633,
-0.13719843327999115,
-0.06005755066871643,
-0.08857758343219757,
0.27877259254455566,
0.109816774725914,
0.186602383852005,
-0.05491140857338905,
0.04727308824658394,
0.06198140233755112,
-0.03347218781709671,
0.1886124461889267,
0.04971275478601456,
-0.17632588744163513,
-0.011229771189391613,
-0.17449168860912323,
0.04392581433057785,
-0.09677662700414658,
0.030633270740509033,
0.034251619130373,
0.1866476982831955,
-0.03757218271493912,
-0.1376330405473709,
-0.08460213243961334,
0.04202171787619591,
0.07198479026556015,
0.08029446750879288,
-0.061180196702480316,
0.017649060115218163,
0.1323874443769455,
-0.043374352157115936,
0.14486421644687653,
0.3081573247909546,
-0.13284601271152496,
0.03377282992005348,
-0.04392073303461075,
0.12828204035758972,
0.002775692380964756,
-0.020391730591654778,
0.0008956772508099675,
-0.09845595061779022,
0.10670603811740875,
0.22555455565452576,
-0.10532840341329575,
0.02519051730632782,
-0.28574326634407043,
0.23266929388046265,
-0.03907973691821098,
0.15046140551567078,
-0.16155554354190826,
-0.05917327105998993,
-0.07486983388662338,
0.4091455340385437,
0.08450707793235779,
0.25931423902511597,
0.04344271123409271,
-0.16598719358444214,
-0.06550376117229462,
-0.0006282474496401846,
-0.06241067498922348,
0.0067996010184288025,
-0.1705138087272644,
-0.10323285311460495,
0.15340425074100494,
-0.07507188618183136,
0.10202031582593918,
-0.13047489523887634,
0.17275308072566986,
0.15777339041233063,
0.0023086208384484053,
0.11804885417222977,
0.08386965841054916,
0.02936692163348198,
-0.2072950154542923,
0.14178839325904846,
-0.06777393072843552,
-0.14248275756835938,
-0.10284960269927979,
-0.09227416664361954,
-0.052011750638484955,
-0.10677600651979446,
0.0670202448964119,
0.16681653261184692,
0.15646471083164215,
0.01396002434194088,
0.11115099489688873,
0.03534480929374695,
-0.11005774140357971,
-0.08339878916740417,
0.04875947907567024,
-0.09560314565896988,
0.06101604178547859,
0.15172679722309113,
0.008666661567986012,
-0.08311975747346878,
-0.04070311412215233,
-0.04145277291536331,
0.06031646579504013,
0.04313866049051285,
-0.019673826172947884,
-0.09220079332590103,
-0.10346929728984833,
-0.0925191193819046,
0.06748027354478836,
0.003744818503037095,
-0.1573467254638672,
0.30743134021759033,
0.11308986693620682,
0.04839135706424713,
0.12822620570659637,
0.16976740956306458,
-0.07915645837783813,
0.14768187701702118,
-0.17415493726730347,
-0.07470609992742538,
-0.25637930631637573,
-0.09816592931747437,
-0.02596134878695011,
-0.33963289856910706,
-0.11848576366901398,
-0.009376325644552708,
0.03722061961889267,
-0.0058540236204862595,
-0.02687237784266472,
0.2746284604072571,
0.264126181602478,
-0.0805312916636467,
0.04917110130190849,
0.34749090671539307,
0.1877133697271347,
0.12295813858509064,
0.022304777055978775,
0.050154078751802444,
-0.05819445848464966,
0.3635837435722351,
0.0312570184469223,
-0.029139146208763123,
0.20686359703540802,
-0.15289074182510376,
0.11743655800819397,
-0.3036479949951172,
0.044641681015491486,
0.2511521279811859,
-0.08233724534511566,
0.002820013090968132,
-0.23823457956314087,
0.09055471420288086,
0.03382318094372749,
-0.09254973381757736,
-0.17601366341114044,
0.05112607777118683,
0.11183295398950577,
-0.0889434814453125,
0.06541327387094498,
-0.10493284463882446,
0.15884846448898315,
0.15108981728553772,
-0.05054387077689171,
0.007043240591883659,
-0.06302706152200699,
0.018785933032631874,
-0.10626735538244247,
-0.07411457598209381,
-0.040905896574258804,
-0.2089257389307022,
-0.08777119964361191,
0.003731156000867486,
-0.1471996307373047,
-0.01659822277724743,
0.12781983613967896,
0.06646021455526352,
-0.00038934595067985356,
0.0378788523375988,
0.11578235030174255,
0.03641975671052933,
-0.15067678689956665,
-0.043205078691244125,
-0.20533637702465057,
0.07046467810869217,
0.034871906042099,
-0.1321396827697754,
0.03684089332818985,
0.20165030658245087,
-0.20136629045009613,
0.07365346699953079,
-0.15197794139385223,
-0.07983934134244919,
0.13694864511489868,
-0.03880767151713371,
0.02736794389784336,
-0.04085616394877434,
0.29902949929237366,
0.06214446201920509,
0.12797389924526215,
0.03716006129980087,
0.10279209166765213,
-0.066229909658432,
0.05205880105495453,
-0.2061351239681244,
-0.007049666251987219,
-0.0473068505525589,
0.10109247267246246,
0.052440330386161804,
-0.0440826453268528,
-0.018329601734876633,
-0.2348237931728363,
-0.07875697314739227,
0.10877465456724167,
-0.12340161204338074,
0.11890599876642227,
0.016862062737345695,
-0.01097448542714119,
-0.08732341974973679,
0.05493244528770447,
0.13212816417217255,
0.17872163653373718,
0.03402381390333176,
-0.116620272397995,
0.028953544795513153,
0.2620968520641327,
0.17000927031040192,
-0.06054007261991501,
-0.2761302590370178,
-0.023697933182120323,
0.008351095020771027,
-0.13061226904392242,
-0.10761181265115738,
0.08118513971567154,
0.04950856417417526,
0.16237296164035797,
-0.11345066875219345,
0.02678748220205307,
-0.01685773767530918,
0.05064651742577553,
0.16465695202350616,
-0.08119135349988937,
-0.3058665096759796,
0.025026801973581314,
0.06784819066524506,
-0.06029687821865082,
0.17883427441120148,
-0.025570781901478767,
0.08445417881011963,
-0.06507895886898041,
0.157377690076828,
0.13959690928459167,
-0.01606084778904915,
0.019420616328716278,
-0.082066111266613,
0.13473311066627502,
-0.08300824463367462,
-0.32028207182884216,
-0.03461414948105812,
0.07777020335197449,
0.20757722854614258,
0.2449503242969513,
-0.17225851118564606,
0.025700803846120834,
-0.21598950028419495,
0.20230752229690552,
0.25283709168434143,
-0.18290722370147705,
0.07811309397220612,
-0.04666152969002724,
-0.14422088861465454,
-0.10233134776353836,
0.24332654476165771,
0.14260588586330414,
-0.006289232522249222,
0.15569615364074707,
0.08485791087150574,
-0.004607705865055323,
0.008227522484958172,
0.19040267169475555,
-0.18533922731876373,
-0.09668808430433273,
0.18038201332092285,
0.10570002347230911,
-0.17222006618976593,
0.026091357693076134,
0.0928332582116127,
0.02907438389956951,
0.03950316831469536,
0.14832645654678345,
0.021278483793139458,
0.012061437591910362,
-0.07137646526098251,
-0.0800376683473587,
0.0914972648024559,
0.042573098093271255,
-0.1926477700471878,
0.09750178456306458,
-0.14975416660308838,
-0.007421333342790604,
-0.024987660348415375,
-0.19340960681438446,
-0.006498423404991627,
-0.007256676442921162,
-0.2723388373851776,
0.12494108825922012,
0.11108118295669556,
0.1386047601699829,
0.20661120116710663,
-0.1119862049818039,
0.12284136563539505,
0.3128937780857086,
-0.013082906603813171,
-0.016397757455706596,
-0.25633955001831055,
0.05552630126476288,
0.06213339790701866,
-0.12246302515268326,
-0.006510905921459198,
0.00019227854500059038,
0.06511316448450089,
0.01736006885766983,
0.05787302553653717,
-0.018857060000300407,
0.26326853036880493,
-0.20453521609306335,
-0.10595348477363586,
-0.061194974929094315,
-0.07730165123939514,
0.05211018770933151,
-0.05872161686420441,
-0.06497647613286972,
-0.12182073295116425,
0.026525957509875298,
0.1932494193315506,
-0.05461833253502846,
0.21517309546470642,
-0.07447446882724762,
-0.08717416226863861,
-0.007280669175088406,
-0.06584027409553528,
-0.20121723413467407,
0.03702342137694359,
0.18650871515274048,
-0.1102050393819809,
0.06403903663158417,
0.2182689756155014,
-0.10957946628332138,
-0.19511692225933075,
0.10273999720811844,
0.366891473531723,
-0.2194899469614029,
0.19521532952785492,
0.013695838861167431,
0.05186484754085541,
0.002996050287038088,
0.09498432278633118,
-0.0023186716716736555,
0.08139226585626602,
-0.058731772005558014,
0.09670662134885788,
0.16196100413799286,
-0.05107489973306656,
0.041026655584573746,
-0.4087865352630615,
0.17291508615016937,
-0.018219230696558952,
-0.006829606834799051,
0.02881619706749916,
0.10484017431735992,
0.1914213001728058,
0.1655104011297226,
0.008021960034966469,
0.11032385379076004,
-0.1768544763326645,
0.13422568142414093,
0.02131233923137188,
-0.1581675261259079,
0.2329687625169754,
0.09610971808433533,
0.12127850204706192,
0.11523929238319397,
-0.16455067694187164,
0.13827721774578094,
0.03590525686740875,
-0.04030174762010574,
-0.18368710577487946,
0.040093258023262024,
-0.09357760101556778,
-0.1167706847190857,
0.007591440808027983,
0.13854475319385529,
0.09249895811080933,
-0.012036120519042015,
-0.04741396754980087,
0.17735223472118378,
0.1774807572364807,
0.03943770006299019,
0.17486099898815155,
0.018737846985459328,
-0.09214078634977341,
-0.06228446960449219,
0.05928019434213638,
0.05219145864248276,
-0.23204423487186432,
0.10449938476085663,
0.20232339203357697,
-0.040422093123197556,
-0.1658446192741394,
-0.1332581639289856,
0.2978995144367218,
-0.0019289249321445823,
-0.11734215170145035,
-0.047954387962818146,
-0.0031430211383849382,
-0.006959661841392517,
0.06271445006132126,
0.17029054462909698,
0.1495530605316162,
0.05171259865164757,
-0.05246107652783394,
0.10732444375753403,
0.19331465661525726,
0.011333429254591465,
0.13556769490242004,
0.014839597046375275,
0.2959831655025482,
0.1424882858991623,
0.1140352264046669,
0.0183454267680645,
-0.22603783011436462,
-0.06091522425413132,
0.05769737437367439,
0.1443035900592804,
0.17440740764141083,
0.03353404626250267,
0.10977537930011749,
-0.03409452363848686,
0.033953748643398285,
-0.13850660622119904,
0.2259918451309204,
-0.06111352518200874,
-0.22945722937583923,
0.11100997030735016,
-0.09605556726455688,
-0.17703698575496674,
-0.18241825699806213,
0.045241113752126694,
0.029747195541858673,
0.24717852473258972,
-0.04759882763028145,
-0.2122514545917511,
0.008397362194955349,
0.14673633873462677,
-0.24061478674411774,
-0.006270172074437141,
0.005223345011472702,
-0.024627219885587692,
0.22582098841667175,
0.12123551219701767,
-0.016629237681627274,
0.045236747711896896,
-0.16793745756149292,
-0.054071005433797836,
-0.04328615963459015,
-0.005187169183045626,
-0.09216886758804321,
0.059704363346099854,
-0.01306526456028223,
0.033954065293073654,
-0.1925940215587616,
-0.06360777467489243,
0.09446411579847336,
0.04398607835173607,
0.06706713885068893,
-0.17493778467178345,
0.15708082914352417,
0.07137583196163177,
-0.08693371713161469,
0.02420363761484623,
0.08160374313592911,
0.3182792365550995,
0.16664288938045502,
-0.03123098984360695,
-0.021632995456457138,
-0.28931453824043274,
0.016273492947220802,
-0.06936988979578018,
0.002560150111094117,
-0.05867917835712433,
0.004207939375191927,
0.25468015670776367,
0.09479930251836777,
-0.16930872201919556,
0.021297520026564598,
-0.18071681261062622,
0.013457897119224072,
0.06765338778495789,
0.1480018049478531,
-0.1688372790813446,
-0.21690578758716583,
-0.1383012980222702,
-0.012595647014677525,
-0.1355208456516266,
0.043900199234485626,
0.14907154440879822,
0.14936499297618866,
-0.051335737109184265,
0.12324397265911102,
-0.12086523324251175,
0.027526505291461945,
0.16662482917308807,
0.001229465357027948,
-0.05922279506921768,
0.08614789694547653,
0.00691084424033761,
-0.1427554488182068,
-0.30909210443496704,
-0.26230451464653015,
-0.06866081058979034,
-0.05586182326078415,
-0.08796084672212601,
0.0009578209719620645,
-0.10701750963926315,
-0.07491643726825714,
-0.079664446413517,
0.0654212161898613,
-0.01759001985192299,
-0.021805506199598312,
0.09427151829004288,
-0.041656699031591415,
0.10448679327964783,
-0.06435322016477585,
0.11406832188367844,
-0.01768522337079048,
-0.10271722078323364,
0.008610685355961323,
0.0954461544752121,
-0.03623056039214134,
0.04687643051147461,
-0.11782588809728622,
0.03707927465438843,
-0.018105313181877136,
-0.10311488807201385,
0.08313380181789398,
-0.04609314352273941,
-0.2760402262210846,
0.09344371408224106,
-0.09885531663894653,
-0.044601920992136,
-0.11413993686437607,
0.0095143411308527,
0.025057533755898476,
0.14527225494384766,
-0.02961946837604046,
0.018788551911711693,
-0.15359488129615784,
-0.1349232792854309,
-0.12903642654418945,
0.01065765880048275,
-0.12141238898038864,
-0.3003799319267273,
-0.22612395882606506,
-0.06639071553945541,
-0.20941320061683655,
-0.1743859350681305,
-0.13799507915973663,
0.164757639169693,
-0.07271096855401993,
-0.061677321791648865,
0.011942475102841854,
0.04636218026280403,
0.05079887807369232,
0.1373201161623001,
-0.12811657786369324,
0.11749524623155594,
0.08349912613630295,
-0.14946742355823517,
0.12363901734352112,
-0.19025368988513947,
-0.09734251350164413,
-0.04580638185143471,
0.281077116727829,
-0.036835718899965286,
-0.02055368945002556,
-0.06779271364212036,
-0.057334236800670624,
-0.08001317083835602,
-0.15015654265880585,
0.204978808760643,
-0.09744120389223099,
-0.15314669907093048,
0.03962584212422371,
0.10244744271039963,
0.06475703418254852,
-0.31307175755500793,
0.09573229402303696,
0.04264943674206734,
0.13056671619415283,
-0.15688563883304596,
0.0704837515950203,
-0.007212191820144653,
0.28128957748413086,
-0.06580164283514023,
0.03387932479381561,
-0.0767827257514,
0.011650282889604568,
-0.19754652678966522,
0.10694728046655655,
0.1399451047182083,
0.15920428931713104,
-0.3257313370704651,
-0.09802387654781342,
0.11339528858661652,
0.21592777967453003,
0.16048909723758698,
0.11989784240722656,
0.10009640455245972,
0.004377583973109722,
0.019903060048818588,
-0.03757595643401146,
0.14247439801692963,
-0.22945252060890198,
0.23862352967262268,
-0.18093034625053406,
0.264046847820282,
-0.01711227372288704,
0.09171536564826965,
0.019569655880331993,
0.10681977868080139,
-0.03744850680232048,
0.06954953074455261,
-0.1322043091058731,
0.27159440517425537,
0.005513254553079605,
-0.07849534600973129,
0.00549121992662549,
-0.17471717298030853,
0.03845607861876488,
0.01572168432176113,
-0.10089108347892761,
0.11296971142292023,
-0.10304278135299683,
-0.019196314737200737,
0.17333583533763885,
-0.08270987868309021,
0.11909231543540955,
-0.049479320645332336,
-0.05732385069131851,
-0.14037851989269257,
-0.06504169851541519,
0.12333928793668747,
-0.02318098582327366,
0.02108277939260006,
0.023449476808309555,
0.0690908282995224,
-0.0924418717622757,
-0.1479746699333191,
0.22988538444042206,
0.1368314027786255,
-0.15524187684059143,
0.010579751804471016,
0.07932648807764053,
-0.07855686545372009,
-0.1351916491985321,
-0.18038594722747803,
-0.05463281646370888,
0.14450451731681824,
0.07993370294570923,
-0.2704760432243347,
-0.16443276405334473,
0.02005043439567089,
0.05645513907074928,
0.13215352594852448,
0.048285309225320816,
0.09125719964504242,
0.18994413316249847,
0.05038271099328995,
0.013059125281870365,
-0.13888506591320038,
0.07837296277284622,
0.26939353346824646,
-0.029668068513274193,
-0.20900297164916992,
0.13837867975234985,
0.15231354534626007,
0.10679600387811661,
-0.018807433545589447,
0.05726169794797897,
-0.04319581389427185,
-0.020328959450125694,
0.08238169550895691,
0.15840394794940948,
0.1342257857322693,
0.14389736950397491,
-0.016626723110675812,
-0.11321350932121277,
0.06237318739295006,
0.042103711515665054,
-0.055525004863739014,
-0.011496607214212418,
0.2935064136981964,
-0.056001465767621994,
0.03959557041525841,
-0.2731325030326843,
-0.16981655359268188,
-0.01914435811340809,
0.13351838290691376,
0.09345946460962296,
0.1800609529018402,
-0.011767898686230183,
-0.11982277780771255,
-0.01874229870736599,
0.1203957051038742,
-0.09398841857910156,
-0.010368269868195057,
0.3107842803001404,
0.01681620255112648,
-0.12877871096134186,
-0.0889117643237114,
-0.10585541278123856,
0.16091176867485046,
-0.034772492945194244,
0.1059112474322319,
-0.07552461326122284,
0.025001898407936096,
-0.0960480198264122,
-0.04664321616292,
0.18530094623565674,
0.06426096707582474,
-0.04976404458284378,
0.002488987287506461,
0.10255707800388336,
-0.043677132576704025,
-0.09885261952877045,
0.013055414892733097,
-0.2370385080575943,
-0.09042160958051682,
0.04012686759233475,
0.024204935878515244,
0.03160203993320465,
0.07626380026340485,
0.04505772143602371,
0.03355393931269646,
-0.12706422805786133,
-0.2763610780239105,
0.04202261567115784,
0.08299915492534637,
-0.18588602542877197,
-0.04042461887001991,
-0.011967502534389496,
0.012562151998281479,
0.02268245629966259,
0.03566000238060951,
-0.015347828157246113,
-0.03594032675027847
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. laboratory, and biochemical findings.ClinicalSkin lesions, typically lower extremity ulcers. Other lesions such as telangiectasias of the face and hands are also common .Recurrent infections, particularly of the skin and respiratory tract Chronic lung disease with digital clubbing and a cystic fibrosis-like phenotype Dysmorphic facial features, including widely spaced eyes, proptosis, depressed nasal bridge, prognathism, thin vermilion of the upper lip, and low anterior and posterior hairline Developmental delay of variable degree Splenomegaly Systemic lupus erythematosus-like phenotype Laboratory. Frequent, although not universal, laboratory findings include the following:Anemia, usually mild (hemoglobin >10 g/dL), but occasionally below that value Thrombocytopenia, usually mild (>100,000 platelets per μL), although rarely it can be lower Elevated liver enzymes, with elevation of aspartate aminotransferase in the 100s Hypergammaglobulinemia, mainly elevation of IgG and IgA, although occasionally also elevation of IgM. Reference | [
-0.13273464143276215,
0.14013953506946564,
0.05694584548473358,
-0.1663355678319931,
0.14487366378307343,
0.08137618005275726,
0.03285215422511101,
-0.04435070976614952,
-0.15023048222064972,
-0.24753937125205994,
0.0017755050212144852,
0.11454417556524277,
0.23572352528572083,
0.08954707533121109,
-0.19140563905239105,
0.12213514000177383,
0.03479676693677902,
0.09139332175254822,
-0.15504255890846252,
-0.01636160910129547,
0.05306916683912277,
-0.0857989490032196,
0.2834334969520569,
0.07882466167211533,
0.23600518703460693,
-0.22061549127101898,
0.08473226428031921,
0.11187863349914551,
-0.07731709629297256,
0.1520538032054901,
0.017612140625715256,
-0.2518160939216614,
-0.11045411974191666,
-0.024672329425811768,
0.07615792006254196,
-0.08138961344957352,
-0.12092740088701248,
-0.19388845562934875,
0.2266789823770523,
-0.06637889891862869,
-0.14550139009952545,
-0.0497235432267189,
0.2518579661846161,
0.05561073124408722,
0.13475348055362701,
-0.2772427201271057,
-0.07504676282405853,
0.0828283503651619,
-0.032951828092336655,
0.07130962610244751,
0.24089892208576202,
-0.252897709608078,
-0.05888564512133598,
-0.08966342359781265,
0.15016548335552216,
-0.07309959083795547,
-0.03921813517808914,
0.08358605951070786,
0.0034621371887624264,
0.17799393832683563,
0.17249710857868195,
-0.14166516065597534,
0.008833818137645721,
-0.44687420129776,
0.17035868763923645,
-0.08221430331468582,
0.05450022220611572,
-0.025237681344151497,
-0.085182785987854,
0.050762839615345,
0.43528369069099426,
0.005660130642354488,
0.10632313042879105,
0.0448228120803833,
-0.12472140789031982,
-0.006837582215666771,
0.004765572026371956,
-0.07919622212648392,
0.0676506832242012,
-0.2125166803598404,
-0.08848722279071808,
0.23064926266670227,
-0.18141677975654602,
0.13480311632156372,
-0.0020276487339287996,
0.36592897772789,
0.2456815391778946,
-0.13013187050819397,
0.15854911506175995,
-0.02383994124829769,
0.056663285940885544,
-0.2594936192035675,
0.15001444518566132,
-0.1116824597120285,
-0.04888838157057762,
-0.0419732928276062,
0.03437492996454239,
-0.10238335281610489,
-0.062166184186935425,
0.004432270769029856,
0.053969502449035645,
0.16780486702919006,
-0.019790194928646088,
0.11244358122348785,
-0.05224692076444626,
-0.3006002604961395,
-0.06816624850034714,
0.14965517818927765,
-0.17793330550193787,
-0.019713157787919044,
0.2587684392929077,
0.0015708096325397491,
0.009827420115470886,
-0.017285065725445747,
-0.05354621633887291,
0.0540119931101799,
-0.08640572428703308,
-0.11369483917951584,
-0.015459811314940453,
-0.1412321776151657,
-0.1211986243724823,
0.025605570524930954,
-0.04179103299975395,
-0.053500838577747345,
0.3210691213607788,
0.005229163449257612,
-0.014836149290204048,
-0.0995045080780983,
0.3479990065097809,
-0.01216889824718237,
-0.0015336779179051518,
-0.07318074256181717,
-0.1730763018131256,
-0.26272550225257874,
-0.06312806159257889,
-0.09075748920440674,
-0.2209320217370987,
-0.28136730194091797,
0.10557403415441513,
-0.11147505789995193,
0.026746084913611412,
0.0006784476572647691,
0.31047534942626953,
0.2235209345817566,
-0.04204993695020676,
0.04564082249999046,
0.38046202063560486,
0.09598051011562347,
0.05264720693230629,
0.11672268062829971,
0.13063646852970123,
-0.2213820070028305,
0.3490639626979828,
-0.06982973217964172,
-0.20069628953933716,
0.19536469876766205,
-0.21412448585033417,
0.1039702296257019,
-0.20451058447360992,
-0.08855533599853516,
0.22815784811973572,
-0.01606100983917713,
0.05854269862174988,
-0.33623525500297546,
0.14098036289215088,
-0.03140375390648842,
-0.045874956995248795,
-0.2998165190219879,
0.26902681589126587,
0.12113696336746216,
-0.03799507021903992,
-0.07848815619945526,
-0.0723174586892128,
0.12382665276527405,
0.1792694628238678,
-0.13749513030052185,
-0.04631081223487854,
0.10148512572050095,
0.06166599318385124,
-0.1821684092283249,
-0.1553363800048828,
-0.02666372060775757,
-0.31451883912086487,
-0.3099783957004547,
0.09342745691537857,
-0.23013179004192352,
-0.03130244091153145,
0.16164414584636688,
0.05610160529613495,
-0.06004312261939049,
0.13333536684513092,
0.1531391441822052,
-0.18146169185638428,
-0.1490515023469925,
-0.040826357901096344,
-0.28265154361724854,
0.09543199092149734,
-0.08052876591682434,
0.010596336796879768,
0.01392651628702879,
0.3103541135787964,
-0.17047204077243805,
0.03249865770339966,
-0.003996295854449272,
-0.05998712033033371,
0.2046760469675064,
-0.06994711607694626,
-0.056916043162345886,
-0.1087970957159996,
0.2797811031341553,
0.11751853674650192,
0.054813142865896225,
0.07111360132694244,
0.1856229454278946,
-0.04442761465907097,
-0.015885507687926292,
-0.16896454989910126,
-0.1032944843173027,
-0.013753293082118034,
0.09406983107328415,
0.021317897364497185,
-0.0038691360969096422,
-0.062370412051677704,
-0.29737111926078796,
-0.16089388728141785,
0.08424196392297745,
-0.05879802629351616,
0.018056171014904976,
-0.04152077063918114,
0.044493671506643295,
-0.22471287846565247,
0.08712132275104523,
0.10829145461320877,
0.1752580851316452,
-0.07773003727197647,
-0.14233267307281494,
-0.056099604815244675,
0.2504291236400604,
0.05651520937681198,
0.14020252227783203,
-0.2197461724281311,
-0.021938759833574295,
-0.010941537097096443,
-0.09825099259614944,
-0.15883785486221313,
0.1714201271533966,
-0.23530642688274384,
0.02827630192041397,
-0.10490092635154724,
0.025917846709489822,
0.02940344624221325,
0.027758503332734108,
0.08259561657905579,
-0.013264470733702183,
-0.3945091962814331,
-0.02443338930606842,
0.26697126030921936,
-0.04511846974492073,
0.04715058207511902,
0.028209339827299118,
0.08688441663980484,
0.04779884219169617,
0.0754314735531807,
0.09392144531011581,
0.04856107756495476,
-0.06259217858314514,
-0.17895230650901794,
0.046355944126844406,
-0.10725940763950348,
-0.3041270673274994,
0.04181907698512077,
0.04104036092758179,
0.07530515640974045,
0.11558469384908676,
-0.17902249097824097,
-0.0627409964799881,
-0.16187717020511627,
0.07534950226545334,
0.24319754540920258,
-0.009440567344427109,
0.053903982043266296,
-0.12434227019548416,
-0.15813471376895905,
-0.11801999807357788,
0.23517070710659027,
0.07114113122224808,
-0.022962316870689392,
0.18659497797489166,
0.018391545861959457,
-0.030678626149892807,
-0.045837219804525375,
0.25965097546577454,
-0.08993466198444366,
-0.14853818714618683,
0.07662630826234818,
-0.013328040018677711,
-0.08433164656162262,
0.10462906211614609,
0.15885896980762482,
0.15006862580776215,
0.14160680770874023,
0.1601163148880005,
0.11061529070138931,
0.07496470957994461,
-0.13217534124851227,
-0.002937266370281577,
0.1147884950041771,
0.17097385227680206,
-0.15267418324947357,
0.022294064983725548,
-0.12606915831565857,
-0.11880169063806534,
0.11680351942777634,
-0.10947134345769882,
-0.047832123935222626,
-0.10666084289550781,
-0.21160514652729034,
0.18969324231147766,
0.15048275887966156,
0.012592962943017483,
0.06078581139445305,
-0.04468429833650589,
0.15442585945129395,
0.29140597581863403,
0.06969525665044785,
0.093674436211586,
-0.1873818188905716,
0.026414617896080017,
-0.024583950638771057,
0.025453267619013786,
0.013161554001271725,
-0.04821401089429855,
0.0004396456934046,
-0.025546489283442497,
0.0013403164921328425,
-0.08757548779249191,
0.3069111406803131,
0.01766582764685154,
-0.09859444200992584,
-0.2528057396411896,
-0.0664222314953804,
-0.034225817769765854,
0.01784738339483738,
-0.07167387008666992,
-0.05007554590702057,
-0.0978478342294693,
0.22885778546333313,
-0.10658440738916397,
0.11223185807466507,
-0.18903937935829163,
-0.11964640021324158,
-0.0039599016308784485,
-0.0017302093328908086,
-0.28095123171806335,
0.17656303942203522,
0.058269888162612915,
-0.1403791755437851,
0.10986635833978653,
0.32358595728874207,
-0.16065111756324768,
-0.2281140238046646,
-0.05352507159113884,
0.32926446199417114,
-0.03675229102373123,
0.1810874193906784,
0.04717148095369339,
-0.045858271420001984,
-0.08573891967535019,
0.19533689320087433,
0.028405409306287766,
0.0904422476887703,
0.03236808255314827,
0.12516263127326965,
0.01756514422595501,
0.11203358322381973,
0.021155543625354767,
-0.38220545649528503,
0.29640594124794006,
0.06984899193048477,
0.026121752336621284,
-0.12766720354557037,
0.17069871723651886,
0.11482179909944534,
0.0929238572716713,
0.09696166217327118,
0.1253223568201065,
-0.14289997518062592,
0.20365744829177856,
0.05388028174638748,
-0.24345572292804718,
0.16915276646614075,
0.05912560597062111,
0.13147419691085815,
0.1632656753063202,
-0.1786496639251709,
0.117035411298275,
-0.10014676302671432,
-0.010022906586527824,
-0.1766236424446106,
0.03923578932881355,
0.0032484063412994146,
-0.06542045623064041,
0.11953741312026978,
0.09581644088029861,
0.11634374409914017,
0.0868116244673729,
-0.020135371014475822,
0.2387378066778183,
0.060062967240810394,
-0.02081737481057644,
0.05590008199214935,
-0.024891018867492676,
-0.21347826719284058,
-0.14542025327682495,
0.040973976254463196,
-0.09928924590349197,
-0.14997465908527374,
0.10597673803567886,
0.17382793128490448,
-0.21187713742256165,
-0.23676815629005432,
-0.14015506207942963,
0.23946094512939453,
-0.0351443737745285,
-0.013993567787110806,
0.028675686568021774,
-0.0070988512597978115,
-0.0076934718526899815,
0.1398973912000656,
0.05437040328979492,
0.05459194630384445,
0.10134424269199371,
0.021917643025517464,
0.019970737397670746,
0.13575807213783264,
0.12476619333028793,
0.009022288955748081,
-0.028574468567967415,
0.34098270535469055,
-0.10455168783664703,
0.11700871586799622,
0.06537150591611862,
-0.2697310149669647,
-0.16397050023078918,
0.09462915360927582,
0.21886298060417175,
0.03827237710356712,
-0.02554752677679062,
-0.024834265932440758,
-0.013670544140040874,
0.19863510131835938,
-0.1876583844423294,
0.12273023277521133,
-0.15219564735889435,
-0.146487757563591,
0.03836887329816818,
-0.04130757972598076,
-0.17824988067150116,
-0.18918681144714355,
-0.010551192797720432,
-0.04682540148496628,
0.006501051131635904,
0.01807516999542713,
-0.152625173330307,
0.1094321608543396,
0.1496373414993286,
-0.11352533847093582,
-0.09346892684698105,
0.009878622367978096,
-0.02417004480957985,
0.15375910699367523,
0.0509682334959507,
0.05737074092030525,
-0.07101467251777649,
-0.12570199370384216,
-0.17390254139900208,
0.12467429041862488,
0.12467903643846512,
-0.06543142348527908,
0.20622529089450836,
-0.10039865225553513,
-0.05177842453122139,
-0.30091723799705505,
0.09017394483089447,
0.011500182561576366,
0.013146014884114265,
0.0007910153944976628,
-0.06155962124466896,
0.18391913175582886,
-0.10911637544631958,
0.10690551996231079,
0.06506603211164474,
-0.05368826165795326,
0.36280378699302673,
0.07744532823562622,
0.04537598788738251,
-0.014084012247622013,
-0.005039070267230272,
0.15271005034446716,
-0.04103366285562515,
0.06472133845090866,
0.019589291885495186,
-0.09415431320667267,
0.1419885754585266,
0.02479347214102745,
0.0420142337679863,
0.020237982273101807,
-0.1807078719139099,
0.0679648295044899,
0.16956256330013275,
0.11779093742370605,
-0.14632122218608856,
-0.13809262216091156,
-0.08562782406806946,
0.15850596129894257,
-0.19348160922527313,
0.024593550711870193,
0.049633584916591644,
0.2183058112859726,
-0.08645548671483994,
0.06243753433227539,
-0.12275996059179306,
-0.060435399413108826,
0.052931368350982666,
-0.09426601231098175,
-0.13344131410121918,
0.08599665015935898,
-0.14075827598571777,
-0.12539559602737427,
-0.2741546630859375,
-0.27455660700798035,
-0.13020557165145874,
-0.13224130868911743,
0.07496591657400131,
0.06750701367855072,
-0.19048720598220825,
-0.0926588773727417,
0.1337500810623169,
-0.039993178099393845,
-0.12991489470005035,
-0.06633405387401581,
0.040749382227659225,
-0.10918302834033966,
-0.003133193589746952,
-0.004077299498021603,
0.11398570984601974,
-0.11168823391199112,
0.0220783744007349,
0.18804876506328583,
0.031215360388159752,
-0.03753742575645447,
-0.05466913431882858,
-0.19077512621879578,
0.024943076074123383,
-0.06536614149808884,
-0.09904016554355621,
0.026277760043740273,
-0.10110913217067719,
-0.1858426332473755,
0.23224294185638428,
0.0006394905503839254,
-0.05534599348902702,
-0.08928196877241135,
0.07376610487699509,
-0.1334705799818039,
0.1995786726474762,
-0.037583235651254654,
0.08759734779596329,
-0.18746910989284515,
-0.23611514270305634,
-0.07159420847892761,
-0.04892025887966156,
-0.11982113122940063,
-0.35443422198295593,
-0.22289155423641205,
-0.1412310004234314,
-0.1612643301486969,
-0.15219461917877197,
-0.15518435835838318,
0.11679716408252716,
-0.1670430451631546,
0.02642115391790867,
0.2639220058917999,
0.17230990529060364,
-0.007347224745899439,
0.11038218438625336,
-0.033010754734277725,
0.11366281658411026,
0.06128452345728874,
-0.09591062366962433,
0.20219916105270386,
-0.2769051194190979,
0.07615439593791962,
0.039674896746873856,
0.3041501045227051,
0.05508321896195412,
-0.011225443333387375,
-0.16592982411384583,
0.01483666431158781,
-0.02053944207727909,
-0.12205382436513901,
0.024869615212082863,
-0.0872066542506218,
-0.03668462112545967,
-0.03455720469355583,
0.20920833945274353,
0.1255618929862976,
-0.1395256668329239,
0.21987557411193848,
0.14276930689811707,
0.09190098196268082,
-0.019277319312095642,
0.14215891063213348,
-0.03438272327184677,
0.13992172479629517,
-0.08769308030605316,
0.06431508809328079,
-0.12332762032747269,
-0.06599222123622894,
-0.13491564989089966,
0.0550604872405529,
0.02274598926305771,
0.24988223612308502,
-0.31549346446990967,
-0.18392573297023773,
0.13794128596782684,
0.08425194770097733,
0.10034795850515366,
0.06402065604925156,
0.06890300661325455,
0.03645411878824234,
0.03091919794678688,
0.14389696717262268,
0.05568686127662659,
-0.15338650345802307,
0.20638777315616608,
-0.017368121072649956,
0.2636811137199402,
0.120486319065094,
0.10055426508188248,
0.09618736058473587,
-0.07903243601322174,
0.2303309589624405,
0.05488553270697594,
-0.020976362749934196,
0.21521112322807312,
-0.00410197488963604,
-0.08083993941545486,
-0.14819297194480896,
-0.22207555174827576,
0.23881632089614868,
-0.04395615682005882,
0.01865282654762268,
0.0003288479056209326,
-0.045572470873594284,
-0.11695157736539841,
0.06724567711353302,
-0.17266058921813965,
-0.008268921636044979,
-0.09492682665586472,
0.044367823749780655,
-0.030001912266016006,
-0.1897585541009903,
0.27359217405319214,
-0.06617136299610138,
-0.13767588138580322,
0.02463153377175331,
0.0347750261425972,
-0.003211267990991473,
-0.22748908400535583,
0.16016946732997894,
0.12223242223262787,
-0.084246426820755,
-0.05206207558512688,
-0.00200690352357924,
-0.0201258584856987,
-0.04454006627202034,
-0.20124340057373047,
-0.029314979910850525,
0.12729519605636597,
0.14556807279586792,
-0.23616141080856323,
-0.07755330950021744,
0.10940281301736832,
0.06636268645524979,
0.20767615735530853,
-0.047963112592697144,
0.033637359738349915,
-0.012329586781561375,
0.02677055448293686,
-0.04580013453960419,
-0.13613466918468475,
0.049117155373096466,
0.09375409781932831,
-0.22024007141590118,
-0.1621784120798111,
0.06396745145320892,
0.16017822921276093,
0.12150134891271591,
0.00711684999987483,
0.006350986193865538,
-0.05006350576877594,
-0.004605900030583143,
0.004395662806928158,
0.12975142896175385,
0.10312271863222122,
0.12982957065105438,
-0.10796479135751724,
-0.08705181628465652,
-0.0008543031290173531,
0.14262060821056366,
-0.02062959410250187,
-0.04053407907485962,
0.33604827523231506,
0.1955871433019638,
0.0016751677030697465,
-0.22886674106121063,
-0.05431925132870674,
-0.03984421119093895,
0.13478043675422668,
0.03697056323289871,
0.3252708315849304,
0.10858434438705444,
-0.1843881756067276,
-0.0034728669561445713,
0.005753304343670607,
-0.020196933299303055,
0.18869730830192566,
0.31874674558639526,
0.015586805529892445,
-0.15926527976989746,
-0.22836509346961975,
-0.20272114872932434,
0.18520434200763702,
-0.05454058200120926,
0.09077540785074234,
-0.014471638016402721,
-0.05533648282289505,
0.04264228790998459,
0.10475312918424606,
0.16538184881210327,
0.2254616916179657,
0.07716994732618332,
0.041862502694129944,
0.05145414546132088,
0.0028454537969082594,
-0.03236357867717743,
0.05754166096448898,
-0.059740595519542694,
0.0034948675893247128,
-0.006048738490790129,
0.12007778882980347,
0.1765110194683075,
0.06626317650079727,
0.1276286244392395,
0.044735461473464966,
-0.12537427246570587,
-0.24819453060626984,
-0.049695003777742386,
-0.07152605801820755,
-0.16851742565631866,
-0.08806521445512772,
0.07771226018667221,
0.10818155854940414,
-0.003947037272155285,
0.0034179706126451492,
-0.008549103513360023,
-0.008127855136990547
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. delay of variable degree Splenomegaly Systemic lupus erythematosus-like phenotype Laboratory. Frequent, although not universal, laboratory findings include the following:Anemia, usually mild (hemoglobin >10 g/dL), but occasionally below that value Thrombocytopenia, usually mild (>100,000 platelets per μL), although rarely it can be lower Elevated liver enzymes, with elevation of aspartate aminotransferase in the 100s Hypergammaglobulinemia, mainly elevation of IgG and IgA, although occasionally also elevation of IgM. Reference ranges for immunoglobulins are age dependent, but upper limits of normal at any age are: IgG ~1600 mg/dL, IgA 350 mg/dL, and IgM 280 mg/dL.IgG levels >2,000 mg/dL have been reported numerous times and as high as 3,680 mg/dL .IgA levels >500 mg/dL have been reported on several occasions and as high as 850 mg/dL .IgM concentrations as high as | [
-0.03665349259972572,
-0.1877797544002533,
-0.07094740867614746,
0.05610547214746475,
0.15124289691448212,
0.22039322555065155,
-0.002455746289342642,
0.03298716992139816,
-0.24284468591213226,
-0.17292015254497528,
0.2711747884750366,
-0.09127525985240936,
0.07445982843637466,
0.09794238954782486,
-0.08299951255321503,
0.09918420016765594,
-0.24074409902095795,
0.09209238737821579,
0.07069414108991623,
0.19162814319133759,
0.17767290771007538,
-0.13831910490989685,
0.17498674988746643,
0.24508315324783325,
0.2353857010602951,
-0.21582986414432526,
-0.051952771842479706,
0.14580149948596954,
0.005730673670768738,
0.06444643437862396,
0.17410969734191895,
0.04259634390473366,
-0.08799620717763901,
-0.038007017225027084,
0.1278982311487198,
-0.17204590141773224,
-0.45551833510398865,
-0.329003244638443,
0.12104964256286621,
-0.2815660238265991,
-0.27216464281082153,
-0.003633568761870265,
0.34498023986816406,
-0.005081132985651493,
0.20042051374912262,
-0.33476683497428894,
-0.0030711505096405745,
-0.059202007949352264,
-0.22984787821769714,
0.08259494602680206,
0.18764068186283112,
-0.022015264257788658,
-0.18595239520072937,
0.07410479336977005,
0.20410363376140594,
0.048535022884607315,
0.016736049205064774,
0.24499787390232086,
0.03413039818406105,
0.120843306183815,
-0.0547851137816906,
-0.02566486783325672,
-0.0012567943194881082,
-0.41369980573654175,
0.1986096352338791,
-0.12549524009227753,
0.02552981674671173,
0.21724934875965118,
-0.010351893492043018,
0.0538618266582489,
0.23473942279815674,
-0.21037960052490234,
0.05196639895439148,
0.07183939218521118,
-0.012949922122061253,
-0.08754808455705643,
0.004824872128665447,
-0.06083930283784866,
0.18890127539634705,
-0.4593683183193207,
-0.07859823852777481,
0.37005117535591125,
-0.12582892179489136,
0.16848814487457275,
-0.0958169475197792,
0.14337365329265594,
0.2752395570278168,
0.03764238581061363,
-0.13680081069469452,
-0.14457710087299347,
0.021003246307373047,
-0.02983264997601509,
0.04704848676919937,
0.11806206405162811,
0.18285469710826874,
-0.03229616954922676,
-0.12262722104787827,
-0.19287411868572235,
0.057205718010663986,
0.04008046165108681,
0.08066130429506302,
0.008500400930643082,
-0.0865119993686676,
-0.15156185626983643,
0.17727269232273102,
-0.22315756976604462,
0.0020081140100955963,
0.21373452246189117,
-0.17049561440944672,
-0.030657516792416573,
0.06957580894231796,
0.038499921560287476,
-0.06115586310625076,
0.05876147374510765,
-0.23088783025741577,
-0.20137719810009003,
-0.08498604595661163,
-0.07450047880411148,
-0.06480052322149277,
-0.15126670897006989,
-0.15939487516880035,
-0.04496500641107559,
0.04847439378499985,
0.15162377059459686,
0.2748994529247284,
-0.016518844291567802,
0.05885925143957138,
-0.1596706360578537,
0.35132840275764465,
0.022596029564738274,
-0.08247169107198715,
-0.06940489262342453,
-0.1375269889831543,
-0.15388672053813934,
-0.21156081557273865,
-0.10514189302921295,
-0.15350113809108734,
-0.2122616022825241,
0.10248616337776184,
-0.18666063249111176,
-0.01345128659158945,
-0.06599438190460205,
0.18354777991771698,
0.18744343519210815,
-0.11399325728416443,
0.02043253742158413,
0.32036933302879333,
-0.09308669716119766,
0.07581735402345657,
0.0812026709318161,
0.15295857191085815,
-0.26464709639549255,
0.1642380952835083,
-0.013303183950483799,
-0.30738750100135803,
0.045104239135980606,
-0.04867240786552429,
0.16559767723083496,
0.03912540525197983,
-0.18672756850719452,
-0.02972179278731346,
-0.009977834299206734,
0.17839470505714417,
-0.34959539771080017,
0.02971738576889038,
0.020510271191596985,
0.028449788689613342,
-0.12057935446500778,
0.5775374174118042,
-0.04359803721308708,
0.09171046316623688,
-0.09920591861009598,
-0.08858956396579742,
-0.1362593024969101,
0.2076888233423233,
-0.11083883047103882,
-0.07313644886016846,
0.011222056113183498,
-0.027903545647859573,
0.142193004488945,
-0.05998385325074196,
-0.05916684493422508,
-0.11673007905483246,
-0.200700581073761,
0.12678664922714233,
-0.39212876558303833,
-0.017005082219839096,
0.2874113619327545,
0.10260201245546341,
0.31267356872558594,
0.38464319705963135,
0.22937501966953278,
-0.23327474296092987,
-0.2253444939851761,
-0.03574902191758156,
-0.10334184765815735,
0.11100689321756363,
-0.09873218834400177,
0.09171361476182938,
-0.16096043586730957,
0.30407607555389404,
-0.027520036324858665,
0.14406266808509827,
0.0011552629293873906,
-0.004120193887501955,
0.1399090588092804,
-0.020934874191880226,
0.01654231734573841,
0.06889041513204575,
0.19709576666355133,
0.2559729218482971,
-0.006092105060815811,
0.03876505419611931,
0.3096954822540283,
0.06558313965797424,
-0.05819365754723549,
-0.07678672671318054,
0.0271014254540205,
0.028785767033696175,
-0.04428262636065483,
-0.17525392770767212,
-0.041468553245067596,
-0.16470980644226074,
-0.483231782913208,
-0.2208382487297058,
0.02875889651477337,
-0.22875721752643585,
-0.19789381325244904,
-0.24287688732147217,
0.14635108411312103,
-0.4556468725204468,
0.10970594733953476,
0.08770064264535904,
0.14178289473056793,
-0.4077197015285492,
-0.3689393997192383,
-0.10501410067081451,
0.23100921511650085,
-0.04546510800719261,
0.20698752999305725,
-0.11137363314628601,
-0.059752609580755234,
-0.10541106015443802,
-0.02098594419658184,
-0.15563775599002838,
-0.005809444468468428,
-0.08275561779737473,
-0.1565289944410324,
-0.05165465548634529,
0.2845953404903412,
0.0770423412322998,
-0.07400433719158173,
0.0018124320777133107,
-0.08351946622133255,
-0.42119038105010986,
-0.12989820539951324,
0.16004690527915955,
-0.21323607861995697,
-0.05891287699341774,
-0.08542545884847641,
-0.0026680983137339354,
0.16062921285629272,
-0.10942148417234421,
0.07133960723876953,
0.021236665546894073,
0.0639030709862709,
-0.29158034920692444,
0.027229411527514458,
-0.012912556529045105,
-0.22694131731987,
-0.1531144380569458,
0.14530855417251587,
0.21994441747665405,
-0.12241744250059128,
-0.1109696626663208,
0.18497639894485474,
-0.08752039074897766,
0.06437061727046967,
0.2235976606607437,
-0.11192534863948822,
0.05090329423546791,
-0.032290950417518616,
-0.2502610385417938,
-0.08834676444530487,
0.2360832393169403,
-0.06169790402054787,
0.03074776940047741,
0.04092754051089287,
-0.01586080528795719,
-0.25853487849235535,
-0.10555791109800339,
0.26996392011642456,
-0.06753172725439072,
-0.05563914775848389,
-0.029932638630270958,
-0.1264079213142395,
-0.19718468189239502,
-0.13346824049949646,
0.3162246346473694,
0.22067998349666595,
0.2909168004989624,
0.07995789498090744,
-0.07753559201955795,
0.12515954673290253,
-0.09465342015028,
0.00824388861656189,
0.0247199647128582,
0.1925603598356247,
-0.045597076416015625,
0.07942883670330048,
-0.13925239443778992,
-0.052478719502687454,
-0.004051621537655592,
-0.014229626394808292,
-0.04342285543680191,
-0.1337907612323761,
-0.0711609423160553,
0.019441431388258934,
0.14285367727279663,
-0.02457134611904621,
-0.05706169456243515,
-0.04592311754822731,
0.07190343737602234,
0.17644847929477692,
-0.12338414788246155,
0.17238938808441162,
-0.07523734867572784,
-0.11733401566743851,
-0.264207124710083,
0.14512595534324646,
0.16091498732566833,
0.04137298837304115,
-0.0874846801161766,
-0.17342965304851532,
-0.08970199525356293,
-0.026992451399564743,
0.433665931224823,
0.07842372357845306,
-0.0466134212911129,
-0.35415521264076233,
0.1510658711194992,
-0.32564854621887207,
0.08878423273563385,
-0.11374824494123459,
0.04576660320162773,
-0.03953266143798828,
0.10714466124773026,
-0.06165188178420067,
-0.04810471832752228,
-0.2130570411682129,
-0.17769017815589905,
-0.25225186347961426,
-0.04295868054032326,
-0.0661432072520256,
0.060721755027770996,
0.07018500566482544,
0.0627620741724968,
0.0540328212082386,
0.2070939987897873,
-0.29389688372612,
-0.10927922278642654,
-0.028610747307538986,
0.07675217092037201,
0.07007679343223572,
0.3072756230831146,
-0.021188542246818542,
0.16955380141735077,
0.0776882916688919,
0.3671833276748657,
-0.03045034408569336,
0.2653452455997467,
0.2624269425868988,
0.27333301305770874,
-0.24565958976745605,
0.18208369612693787,
0.06951180845499039,
-0.35765498876571655,
0.34372851252555847,
-0.013209204189479351,
-0.037036050111055374,
-0.140479177236557,
0.3566027581691742,
0.11912593245506287,
0.3329676389694214,
0.14317002892494202,
0.11964477598667145,
-0.29334601759910583,
0.07980086654424667,
0.004261755384504795,
-0.12074392288923264,
0.17341001331806183,
0.24107421934604645,
-0.09746919572353363,
0.2220238745212555,
-0.053537383675575256,
-0.04483439028263092,
-0.22516776621341705,
-0.008800264447927475,
-0.267779141664505,
0.23664487898349762,
0.018172986805438995,
-0.14989063143730164,
0.26757168769836426,
-0.01126555074006319,
0.28014075756073,
0.2613171935081482,
0.04349873960018158,
0.08204205334186554,
0.19300030171871185,
0.07263952493667603,
-0.01830163411796093,
-0.12762205302715302,
-0.20087328553199768,
-0.08140666782855988,
-0.15026772022247314,
-0.22585082054138184,
0.15012964606285095,
0.10599248111248016,
0.3361934423446655,
-0.2872050404548645,
-0.10905908793210983,
0.07653886079788208,
0.29441753029823303,
-0.09250195324420929,
0.08816270530223846,
0.12210875749588013,
0.09738591313362122,
-0.01918153278529644,
0.2502692639827728,
0.13118863105773926,
0.2616897523403168,
0.1615162491798401,
0.10172548145055771,
0.02435700036585331,
0.2730083465576172,
-0.01274167001247406,
-0.0033764755353331566,
-0.031489335000514984,
0.21312032639980316,
-0.3829609751701355,
0.264969140291214,
0.02729460783302784,
-0.3280811309814453,
-0.22853392362594604,
-0.08280810713768005,
0.15663860738277435,
0.005739652086049318,
-0.041808392852544785,
-0.15288574993610382,
-0.02380312792956829,
0.12166852504014969,
-0.1501869559288025,
0.09815669059753418,
-0.005078422836959362,
0.021870750933885574,
-0.04585940018296242,
0.10887110978364944,
-0.09319337457418442,
-0.1619834303855896,
-0.06871896237134933,
-0.22449077665805817,
-0.287563294172287,
0.1027296781539917,
-0.06802848726511002,
0.029125520959496498,
0.12406613677740097,
-0.08478406071662903,
-0.15252268314361572,
-0.07768218219280243,
0.014214630238711834,
-0.06567468494176865,
-0.031416475772857666,
0.18347349762916565,
-0.26344287395477295,
0.018152505159378052,
-0.04958607628941536,
0.12359870225191116,
0.23263752460479736,
0.06114751845598221,
0.2578648030757904,
-0.11911031603813171,
0.015781840309500694,
-0.10008592903614044,
0.19908933341503143,
0.0844561755657196,
0.09044084697961807,
-0.20601503551006317,
-0.17796765267848969,
0.21640239655971527,
-0.15018725395202637,
0.10235724598169327,
0.08396872133016586,
-0.27410227060317993,
0.29247182607650757,
0.029447896406054497,
-0.08382458984851837,
0.02169865369796753,
0.14294441044330597,
-0.08327793329954147,
0.020533159375190735,
0.11121620982885361,
0.22950297594070435,
0.07918857783079147,
-0.10843152552843094,
0.1107850894331932,
0.11561139672994614,
-0.12613391876220703,
-0.04853847250342369,
0.19858571887016296,
0.2526611387729645,
0.11194252222776413,
-0.11369410902261734,
0.12418601661920547,
-0.2032766342163086,
0.08040668070316315,
-0.3126829266548157,
0.20695362985134125,
-0.012714535929262638,
0.11947730928659439,
0.05137496441602707,
-0.06511017680168152,
-0.10413883626461029,
0.06691960990428925,
-0.1014130637049675,
-0.11557544022798538,
-0.3729235529899597,
0.14491218328475952,
-0.1890169084072113,
-0.12015355378389359,
-0.21598754823207855,
-0.15233133733272552,
-0.17396795749664307,
-0.08939371258020401,
0.25705045461654663,
0.24814224243164062,
-0.03728608787059784,
-0.14653314650058746,
0.042475588619709015,
0.07292994856834412,
-0.03960669785737991,
-0.11063740402460098,
0.004812522791326046,
-0.17241449654102325,
-0.06352562457323074,
-0.1754036843776703,
0.12695354223251343,
-0.07149447500705719,
0.10823144763708115,
0.27203747630119324,
-0.013437124900519848,
-0.019724028185009956,
-0.10073909163475037,
-0.005204352550208569,
0.0023810439743101597,
-0.2466345578432083,
0.14083488285541534,
0.21999743580818176,
-0.2647390067577362,
-0.031785573810338974,
0.08612900227308273,
-0.02356247417628765,
-0.12802955508232117,
-0.14055687189102173,
0.007318355608731508,
-0.23302987217903137,
0.07922040671110153,
0.1353071630001068,
-0.24869441986083984,
-0.17409442365169525,
-0.18863297998905182,
-0.16221319139003754,
-0.005883177742362022,
-0.07062597572803497,
-0.192116379737854,
-0.059564538300037384,
0.08725399523973465,
-0.0653364509344101,
-0.013802217319607735,
-0.057899557054042816,
0.0798521488904953,
-0.14243058860301971,
-0.14178556203842163,
0.29741382598876953,
0.21001769602298737,
-0.050003811717033386,
-0.002598976716399193,
-0.09512362629175186,
0.015730762854218483,
-0.019373368471860886,
0.08401064574718475,
-0.047240279614925385,
-0.16209739446640015,
0.06740972399711609,
-0.01295218151062727,
0.2174891233444214,
0.34513765573501587,
-0.021224230527877808,
-0.12429838627576828,
0.07852745056152344,
-0.15643753111362457,
0.05606216564774513,
-0.07949769496917725,
-0.18918099999427795,
-0.09117010235786438,
-0.15770962834358215,
0.15102793276309967,
0.3395390510559082,
-0.19484847784042358,
0.03677227720618248,
0.032663311809301376,
0.09283529967069626,
0.024099234491586685,
0.15954431891441345,
-0.1994478553533554,
0.010294404812157154,
-0.3381351828575134,
-0.04964832589030266,
-0.32002854347229004,
0.04942850023508072,
-0.0958850085735321,
0.09925802052021027,
-0.01776399463415146,
0.31701380014419556,
0.11723446100950241,
-0.2544955909252167,
0.3167576789855957,
0.04053914546966553,
-0.09609345346689224,
0.0524011105298996,
0.017832543700933456,
0.07487548887729645,
0.07151991128921509,
0.18748486042022705,
-0.05583951249718666,
0.024618586525321007,
0.05850575491786003,
0.08164931833744049,
0.2097182720899582,
0.14200998842716217,
-0.03697286546230316,
0.09608157724142075,
-0.1383853256702423,
0.24385160207748413,
0.11680416017770767,
-0.045796867460012436,
0.08389678597450256,
-0.1461113542318344,
-0.011434032581746578,
-0.19981378316879272,
-0.10472362488508224,
0.3868773579597473,
-0.025430778041481972,
0.24664197862148285,
-0.233334019780159,
0.13988523185253143,
-0.13689295947551727,
-0.04598487541079521,
-0.2180062234401703,
0.019107848405838013,
-0.2616797685623169,
0.09668097645044327,
-0.1052960604429245,
-0.16255122423171997,
0.16760899126529694,
-0.06886913627386093,
-0.2087300568819046,
-0.028250807896256447,
-0.1804259866476059,
0.21336109936237335,
-0.24531866610050201,
0.11121227592229843,
0.0941186249256134,
-0.08908935636281967,
-0.2708354890346527,
-0.059040457010269165,
0.05412289500236511,
-0.08337776362895966,
0.04686881601810455,
-0.13877403736114502,
0.26378339529037476,
-0.10730814933776855,
-0.15739762783050537,
-0.07355093210935593,
-0.0019813396502286196,
0.19228047132492065,
0.2587215304374695,
0.08395016938447952,
0.08063808083534241,
0.1372770518064499,
-0.057627882808446884,
-0.05417168512940407,
0.17711831629276276,
0.047353848814964294,
0.018887730315327644,
-0.2990427613258362,
-0.012935581617057323,
0.12020324915647507,
0.2026459276676178,
0.035099901258945465,
-0.02482529543340206,
0.0022596397902816534,
-0.07389817386865616,
0.033202845603227615,
0.08586983382701874,
0.07557027041912079,
-0.007037973962724209,
0.13796435296535492,
-0.10892120748758316,
-0.026268422603607178,
-0.25897061824798584,
0.05515184998512268,
0.10918452590703964,
-0.0870637372136116,
0.3215993344783783,
0.27841416001319885,
0.06528705358505249,
-0.02622373215854168,
0.07697628438472748,
-0.10673616826534271,
-0.030911481007933617,
0.00025297308457084,
0.20516417920589447,
0.057449039071798325,
-0.11226208508014679,
-0.015754302963614464,
0.019356103613972664,
-0.13547632098197937,
0.31860703229904175,
0.18668973445892334,
-0.008762398734688759,
-0.3351876437664032,
-0.3659188747406006,
-0.19122174382209778,
0.13736765086650848,
-0.06376626342535019,
-0.03915337100625038,
0.0707944706082344,
-0.19617505371570587,
0.0532953180372715,
0.12842588126659393,
-0.2796422839164734,
0.21146346628665924,
0.050656430423259735,
0.06454396992921829,
0.027524176985025406,
0.09187527000904083,
-0.06540203094482422,
-0.07658106833696365,
0.03766055032610893,
-0.015427753329277039,
0.05108555778861046,
0.24305212497711182,
0.18204008042812347,
0.004095208831131458,
0.17969444394111633,
0.21707864105701447,
-0.027357064187526703,
-0.06451420485973358,
-0.02158624678850174,
-0.020080020651221275,
-0.2695034444332123,
-0.20199765264987946,
0.26352056860923767,
0.2204025536775589,
-0.048016540706157684,
-0.054947782307863235,
0.0003607017279136926,
0.03728391230106354
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. also elevation of IgM. Reference ranges for immunoglobulins are age dependent, but upper limits of normal at any age are: IgG ~1600 mg/dL, IgA 350 mg/dL, and IgM 280 mg/dL.IgG levels >2,000 mg/dL have been reported numerous times and as high as 3,680 mg/dL .IgA levels >500 mg/dL have been reported on several occasions and as high as 850 mg/dL .IgM concentrations as high as 568 mg/dL have been described .Hypocomplementemia. Levels of C3 ranging from 30 to 74 mg/dL (normal: 75-175 mg/dL) have been published , with C4 as low as 9 mg/dL (normal: 20-40 mg/dL) .Biochemical. Prolidase deficiency is characterized by massive imidodipeptiduria* (10-30 mmol/day) on urine amino acid analysis .In individuals with prolidase | [
-0.005677339620888233,
-0.14964331686496735,
-0.11104766279459,
-0.05781262740492821,
0.14170566201210022,
0.2913573682308197,
-0.1128985658288002,
-0.040067385882139206,
-0.23368102312088013,
-0.17819072306156158,
0.31166306138038635,
0.07178115844726562,
0.07293969392776489,
0.08310157805681229,
-0.060130733996629715,
0.1410466432571411,
-0.07759752869606018,
0.045491885393857956,
0.049822453409433365,
0.052127718925476074,
0.032256241887807846,
-0.09539741277694702,
0.1968422681093216,
0.3603029251098633,
0.21152295172214508,
-0.1471673995256424,
-0.05129275470972061,
0.03736833482980728,
-0.001581447315402329,
0.07051685452461243,
0.14311490952968597,
-0.0218494962900877,
-0.12015930563211441,
0.007781420834362507,
0.12487933784723282,
0.000050922804803121835,
-0.27331385016441345,
-0.18899478018283844,
0.028166867792606354,
-0.19532935321331024,
-0.2535775601863861,
-0.11065301299095154,
0.29594820737838745,
0.06161188706755638,
0.04133570194244385,
-0.2062268853187561,
0.045839715749025345,
0.0012763588456436992,
-0.2546555697917938,
0.2003803551197052,
0.19099879264831543,
-0.03240092843770981,
-0.2506347894668579,
0.11787590384483337,
0.1932438611984253,
0.11195193231105804,
0.06137663498520851,
0.29420042037963867,
0.0812273845076561,
-0.06440979987382889,
-0.03628935664892197,
-0.10488957911729813,
-0.004325660411268473,
-0.36290302872657776,
0.31956833600997925,
-0.2622257471084595,
0.19245681166648865,
0.08028507232666016,
-0.1293591409921646,
-0.11930309981107712,
0.369399756193161,
-0.07961808890104294,
0.038991596549749374,
0.06590354442596436,
0.01318968553096056,
-0.08892460912466049,
0.02975044958293438,
-0.14083631336688995,
0.04922012984752655,
-0.33512061834335327,
-0.06629688292741776,
0.24759717285633087,
-0.05208257958292961,
0.12260409444570541,
0.026004303246736526,
0.2681311070919037,
0.3105336129665375,
0.13275112211704254,
-0.04836887866258621,
-0.12043493241071701,
-0.019077494740486145,
-0.08695141971111298,
0.10014285147190094,
-0.04621175676584244,
0.1161642000079155,
-0.11027740687131882,
-0.10779893398284912,
-0.0959128811955452,
-0.05266132578253746,
0.1808910220861435,
0.02999497577548027,
-0.0020928734447807074,
-0.09138355404138565,
-0.060084883123636246,
0.18639104068279266,
-0.1819705367088318,
-0.012385615147650242,
0.12694653868675232,
-0.14640739560127258,
-0.004523079376667738,
0.00859116856008768,
0.09189215302467346,
-0.12464853376150131,
0.1448032706975937,
-0.22730349004268646,
-0.11055222153663635,
0.061011288315057755,
-0.0726686492562294,
-0.18976137042045593,
-0.19416700303554535,
-0.0025656616780906916,
0.06366030126810074,
0.07164222002029419,
-0.0012457111151888967,
0.17881125211715698,
0.07275739312171936,
0.22884641587734222,
0.059982240200042725,
0.39556747674942017,
-0.03167099133133888,
-0.09063121676445007,
-0.004177745431661606,
-0.07404372841119766,
-0.12085853517055511,
-0.13702726364135742,
0.02058580331504345,
-0.018536457791924477,
-0.09354900568723679,
0.09612386673688889,
-0.15818966925144196,
-0.03137027099728584,
-0.01802072860300541,
0.16442905366420746,
0.22658419609069824,
-0.0014769881963729858,
0.09769086539745331,
0.30408352613449097,
-0.16009849309921265,
0.10228312015533447,
0.12210650742053986,
0.17515182495117188,
-0.17731744050979614,
0.22553078830242157,
0.0684351772069931,
-0.20720262825489044,
0.0572076179087162,
-0.06591489911079407,
0.002842326881363988,
-0.10839521884918213,
0.040369708091020584,
-0.0748867616057396,
-0.08425762504339218,
0.22099439799785614,
-0.09625805914402008,
0.01169507671147585,
-0.019478237256407738,
-0.0003238050558138639,
-0.022424886003136635,
0.5326387286186218,
0.09601885080337524,
0.04277189448475838,
-0.12767362594604492,
-0.013609904795885086,
-0.12080889940261841,
0.27161672711372375,
-0.18104128539562225,
-0.06017942726612091,
0.026045633479952812,
-0.06699726730585098,
0.07292519509792328,
-0.04766274243593216,
-0.005002176389098167,
-0.18964903056621552,
-0.08106589317321777,
-0.0545671246945858,
-0.28593072295188904,
0.04804516211152077,
0.1442645639181137,
0.11569986492395401,
0.26937833428382874,
0.26984015107154846,
0.09226911514997482,
-0.1485985368490219,
-0.16477958858013153,
0.06139588728547096,
-0.15660667419433594,
0.07270139455795288,
0.017851872369647026,
-0.05009626969695091,
-0.024831756949424744,
0.28317946195602417,
-0.045433156192302704,
0.19985143840312958,
-0.055210333317518234,
-0.004530415404587984,
0.22880803048610687,
-0.057292390614748,
0.08231020718812943,
-0.018236152827739716,
0.26813119649887085,
0.17631228268146515,
0.08337393403053284,
0.052036553621292114,
0.3296365737915039,
-0.0732421725988388,
-0.18355844914913177,
-0.27433449029922485,
-0.07202222943305969,
0.08248031139373779,
-0.11244124919176102,
-0.32054194808006287,
-0.05617859587073326,
-0.14386065304279327,
-0.30192500352859497,
-0.054164789617061615,
0.01779656484723091,
-0.3252781927585602,
-0.0661044716835022,
-0.13097935914993286,
0.13272446393966675,
-0.3226427435874939,
0.18721610307693481,
0.1429169625043869,
0.13850833475589752,
-0.27928292751312256,
-0.5420407056808472,
-0.07711270451545715,
0.24922649562358856,
-0.06262984126806259,
0.09135648608207703,
-0.24183373153209686,
-0.003054385306313634,
-0.10129250586032867,
0.03321210294961929,
-0.07029794156551361,
0.08709035813808441,
-0.0952155739068985,
-0.04966898635029793,
-0.059282395988702774,
0.2414112389087677,
0.07590997219085693,
0.00901018176227808,
-0.06200391799211502,
-0.11478029936552048,
-0.3497789800167084,
-0.002174140652641654,
0.1656801402568817,
-0.23902632296085358,
0.042875029146671295,
-0.0816921815276146,
-0.020591305568814278,
0.09702087193727493,
-0.07026660442352295,
0.10479388386011124,
-0.00022940538474358618,
0.08059591054916382,
-0.18461279571056366,
-0.01697942428290844,
0.03828205540776253,
-0.3436364531517029,
-0.14774970710277557,
-0.013787060044705868,
0.19923336803913116,
-0.12192170321941376,
-0.00583409471437335,
-0.012380773201584816,
-0.10580708086490631,
-0.03175045922398567,
0.15308289229869843,
-0.07248722016811371,
-0.18491576611995697,
-0.09464465081691742,
-0.17487086355686188,
-0.08655249327421188,
0.32477837800979614,
0.0039670527912676334,
-0.09732569754123688,
0.11518304795026779,
0.05504879727959633,
-0.015488854609429836,
-0.005824049934744835,
0.30087903141975403,
-0.1401875913143158,
0.029634758830070496,
-0.010151916183531284,
-0.02262957952916622,
-0.20341163873672485,
-0.09960772097110748,
0.17564761638641357,
0.28944769501686096,
0.301809698343277,
-0.015973692759871483,
-0.062677763402462,
0.0045523932203650475,
-0.3022986352443695,
-0.01619650237262249,
0.026831386610865593,
0.24259667098522186,
-0.01351916417479515,
0.16151906549930573,
-0.18423208594322205,
0.010392159223556519,
-0.08636128902435303,
-0.1253049075603485,
0.004009409807622433,
-0.10586328059434891,
-0.13134771585464478,
0.2027200162410736,
0.1416403204202652,
0.06935518234968185,
0.20844337344169617,
-0.19408343732357025,
0.09344160556793213,
0.28798383474349976,
-0.3030414581298828,
0.13948918879032135,
-0.029150236397981644,
-0.06899775564670563,
-0.23362499475479126,
0.040278322994709015,
0.034513574093580246,
-0.0012916217092424631,
0.023035811260342598,
-0.21797314286231995,
0.05546709522604942,
0.18952977657318115,
0.45605698227882385,
-0.005292472895234823,
-0.03624030202627182,
-0.08952819555997849,
0.10336259752511978,
-0.24920368194580078,
0.12576395273208618,
-0.30365946888923645,
-0.03629029914736748,
-0.09922213107347488,
0.05293690785765648,
0.0967397466301918,
0.0264278594404459,
-0.06714718788862228,
-0.1476326584815979,
-0.1586454063653946,
-0.015371465124189854,
-0.05513400584459305,
-0.012790107168257236,
0.1724659651517868,
0.19092725217342377,
0.043876390904188156,
0.2358006238937378,
-0.39294102787971497,
0.007477554492652416,
0.026828791946172714,
0.07928343117237091,
0.03264236822724342,
0.19063854217529297,
0.10647838562726974,
0.11995118111371994,
0.08304191380739212,
0.15599524974822998,
-0.08282826840877533,
0.0026127484161406755,
0.08266053348779678,
0.26080405712127686,
-0.1467461735010147,
0.19136281311511993,
0.03136008232831955,
-0.3695738911628723,
0.22540700435638428,
0.041148100048303604,
-0.026896804571151733,
-0.21210822463035583,
0.28039300441741943,
0.0810929611325264,
0.4159471094608307,
0.1641205996274948,
0.30361396074295044,
-0.16136892139911652,
0.08647608757019043,
0.1934317648410797,
-0.09026754647493362,
0.1894770860671997,
0.2940451502799988,
-0.08258996903896332,
0.1850709170103073,
-0.06142013520002365,
-0.0808364674448967,
-0.22069689631462097,
-0.017178233712911606,
-0.11665893346071243,
0.3099985122680664,
-0.0441095195710659,
-0.08281273394823074,
0.1900181770324707,
-0.06960602104663849,
0.33881714940071106,
0.24459190666675568,
-0.07337068021297455,
0.05366005748510361,
0.2152044028043747,
-0.02707967720925808,
0.026427868753671646,
-0.019978925585746765,
-0.20401795208454132,
-0.13426326215267181,
-0.04816034063696861,
-0.12335336208343506,
0.13323244452476501,
0.19931380450725555,
0.3996840715408325,
-0.10618507117033005,
-0.11123751848936081,
-0.0463448166847229,
0.2854464650154114,
-0.0015629575354978442,
0.0575166679918766,
-0.005301740486174822,
0.1236422136425972,
-0.04551972448825836,
0.29323363304138184,
0.1973135769367218,
0.30082863569259644,
0.18124307692050934,
0.0000520937901455909,
0.03196334466338158,
0.19803397357463837,
-0.20622670650482178,
-0.0460280179977417,
0.11791730672121048,
0.2714584767818451,
-0.24984855949878693,
0.3091906011104584,
-0.010385128669440746,
-0.2695971429347992,
-0.20706309378147125,
-0.19042091071605682,
0.012796741910278797,
-0.009902801364660263,
0.0034217718057334423,
0.035722702741622925,
0.11855009943246841,
0.07480991631746292,
-0.2154063731431961,
-0.1071343645453453,
-0.031064948067069054,
-0.017937004566192627,
-0.05630338937044144,
-0.07522768527269363,
-0.1611822545528412,
-0.08114074170589447,
-0.026264216750860214,
-0.22131793200969696,
-0.09793715924024582,
-0.06993439048528671,
-0.029647905379533768,
-0.04788564518094063,
0.16875320672988892,
-0.1079104021191597,
-0.10492916405200958,
0.028857113793492317,
0.07014156132936478,
0.11969321221113205,
0.08065832406282425,
0.015582678839564323,
-0.20320503413677216,
0.027430498972535133,
-0.08821607381105423,
0.03767208382487297,
0.07687672972679138,
0.04160464555025101,
0.4034421443939209,
-0.022932952269911766,
0.06413416564464569,
-0.17140379548072815,
0.04979007691144943,
0.05870040878653526,
-0.05586491525173187,
-0.2076030969619751,
-0.2003100961446762,
0.1897737830877304,
0.06447749584913254,
0.0915214940905571,
0.12498654425144196,
-0.11882821470499039,
0.3361021876335144,
-0.06676118075847626,
-0.16203442215919495,
-0.0632878914475441,
0.10954323410987854,
-0.02906438149511814,
0.03983553126454353,
0.12699583172798157,
0.22620268166065216,
0.020763127133250237,
0.018618209287524223,
0.20532050728797913,
-0.12965109944343567,
-0.14406718313694,
0.06342356652021408,
0.14221392571926117,
0.26475363969802856,
0.09060171991586685,
-0.05411698296666145,
-0.056595578789711,
-0.1083761528134346,
0.013346805237233639,
-0.12995271384716034,
0.33946099877357483,
0.08710331469774246,
0.16286122798919678,
-0.033137038350105286,
0.05569292977452278,
-0.10440107434988022,
0.015968231484293938,
0.017490925267338753,
-0.1439903974533081,
-0.43375006318092346,
0.14852498471736908,
0.043148502707481384,
-0.24613171815872192,
-0.24053357541561127,
-0.1272270232439041,
-0.15519969165325165,
-0.23527581989765167,
0.18666206300258636,
0.17837895452976227,
-0.10357323288917542,
-0.18387120962142944,
0.07395436614751816,
0.13499875366687775,
-0.06376753002405167,
-0.07080814987421036,
-0.011052502319216728,
-0.04395199567079544,
-0.13964682817459106,
-0.16226473450660706,
0.08820708096027374,
-0.0904250517487526,
-0.06996278464794159,
0.1837635636329651,
-0.030377371236681938,
-0.1050720363855362,
-0.030344294384121895,
0.026879649609327316,
0.058963946998119354,
-0.13087545335292816,
0.05198630318045616,
0.1748458445072174,
-0.25802505016326904,
-0.09112027287483215,
-0.03292062133550644,
-0.12032893300056458,
-0.12263794243335724,
-0.04117092117667198,
-0.0859404057264328,
-0.18861131370067596,
0.20707367360591888,
-0.013626202009618282,
-0.19313737750053406,
-0.1690913736820221,
-0.04360935837030411,
-0.10866698622703552,
-0.0011142053408548236,
0.04034155607223511,
-0.03061709925532341,
-0.1704878956079483,
0.19151027500629425,
-0.07128402590751648,
-0.07483527809381485,
-0.061918891966342926,
0.09354842454195023,
-0.21551327407360077,
-0.1212240532040596,
0.3296714425086975,
0.19552241265773773,
0.06842312961816788,
0.007145672105252743,
0.013342712074518204,
-0.08746584504842758,
-0.07012025266885757,
-0.15985281765460968,
0.010506977327167988,
-0.1814918965101242,
-0.06114894524216652,
-0.10892140865325928,
0.06090119108557701,
0.05674440413713455,
0.04320787638425827,
-0.052145227789878845,
0.04039391502737999,
-0.19054833054542542,
0.014907749369740486,
-0.14853736758232117,
-0.18615257740020752,
-0.21844199299812317,
-0.17177902162075043,
0.11416302621364594,
0.3552815616130829,
-0.16743329167366028,
0.1983073353767395,
-0.032131679356098175,
0.16567076742649078,
-0.10364681482315063,
0.0816817432641983,
-0.03107590414583683,
0.045343052595853806,
-0.1557873636484146,
0.06585489958524704,
-0.23089946806430817,
-0.03919418528676033,
-0.2674776315689087,
0.17965923249721527,
-0.02615213394165039,
0.24899163842201233,
-0.026691948994994164,
-0.16398614645004272,
0.22995606064796448,
0.11663231998682022,
-0.07522395253181458,
0.14441260695457458,
0.013813162222504616,
0.11316639930009842,
0.05503968521952629,
0.0006217922200448811,
-0.011955266818404198,
-0.10964954644441605,
-0.0188900176435709,
0.12423604726791382,
0.3647803068161011,
0.017030855640769005,
-0.05795646831393242,
-0.028791014105081558,
-0.1664251685142517,
0.09938563406467438,
0.10251768678426743,
-0.07497658580541611,
0.07878445088863373,
-0.1263171285390854,
0.010462069883942604,
-0.16974502801895142,
-0.10205437988042831,
0.28974464535713196,
-0.1232980266213417,
0.006160933058708906,
-0.07098105549812317,
0.07463757693767548,
-0.059481631964445114,
0.14258962869644165,
-0.23481348156929016,
-0.04284235090017319,
-0.22439736127853394,
0.27013054490089417,
-0.18392044305801392,
-0.07329095900058746,
0.01978994347155094,
-0.08196356147527695,
-0.14266714453697205,
0.03592716157436371,
-0.20475544035434723,
0.18832756578922272,
-0.21046192944049835,
0.09669210016727448,
0.15633566677570343,
-0.11095847934484482,
-0.11723838746547699,
0.05658750608563423,
-0.07717877626419067,
-0.11315955966711044,
0.03205249831080437,
0.062338367104530334,
0.26842689514160156,
-0.20845459401607513,
-0.22812291979789734,
-0.03999406099319458,
-0.06567344814538956,
0.0859953761100769,
0.3226783275604248,
0.08790803700685501,
0.014864861965179443,
0.12363960593938828,
0.024710794910788536,
-0.01923014223575592,
0.1569516658782959,
-0.09660626947879791,
0.1875264048576355,
-0.25969046354293823,
-0.057891782373189926,
0.11069663614034653,
0.29588210582733154,
0.02960638329386711,
-0.04478383809328079,
0.0053625572472810745,
-0.02544393017888069,
0.0003281695826444775,
0.030496444553136826,
0.13714341819286346,
0.09229512512683868,
0.0036945997271686792,
-0.20519483089447021,
-0.09975410997867584,
-0.2643049955368042,
-0.106729656457901,
0.023337241262197495,
0.0015771315665915608,
0.3796826899051666,
0.2806834280490875,
0.25325900316238403,
-0.08204483240842819,
-0.06500453501939774,
-0.1965397149324417,
0.017834899947047234,
-0.07642436772584915,
-0.00974692776799202,
-0.01329906564205885,
-0.02929203025996685,
0.05565609037876129,
0.008177424781024456,
-0.12390290200710297,
0.2523670792579651,
0.21439693868160248,
-0.02679193764925003,
-0.3341837525367737,
-0.31660255789756775,
-0.11646915227174759,
0.05385487899184227,
-0.16014304757118225,
-0.06681033968925476,
0.14568589627742767,
-0.15510347485542297,
-0.027713613584637642,
0.16413722932338715,
-0.20991258323192596,
0.24945083260536194,
0.14512735605239868,
0.13823693990707397,
0.06654631346464157,
0.17550623416900635,
-0.09539104998111725,
-0.11073718219995499,
-0.1091034933924675,
-0.17534631490707397,
-0.015639295801520348,
0.3240292966365814,
0.27585369348526,
-0.02740933559834957,
0.00862120185047388,
0.15353146195411682,
0.05425503849983215,
-0.0791148990392685,
-0.1029641255736351,
-0.02669026516377926,
-0.2710183262825012,
-0.14580243825912476,
0.07719045877456665,
0.1364620327949524,
0.09150049835443497,
-0.08772186934947968,
-0.05342612415552139,
-0.061947114765644073
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. .IgM concentrations as high as 568 mg/dL have been described .Hypocomplementemia. Levels of C3 ranging from 30 to 74 mg/dL (normal: 75-175 mg/dL) have been published , with C4 as low as 9 mg/dL (normal: 20-40 mg/dL) .Biochemical. Prolidase deficiency is characterized by massive imidodipeptiduria* (10-30 mmol/day) on urine amino acid analysis .In individuals with prolidase deficiency imidodipeptiduria has been detected as early as in the newborn period, even in the absence of signs or symptoms of the disease. (This finding has been used as the basis for urinary newborn screening in Quebec .)Under normal circumstances the urinary excretion of glycylproline is negligible ; thus, the absence of detectable imidodipeptiduria in properly processed samples is sufficient evidence to rule out a diagnosis of prolidase deficiency .Click here (pdf | [
-0.05399395152926445,
0.15273576974868774,
-0.11708561331033707,
-0.27416276931762695,
-0.0083491001278162,
0.2451229989528656,
-0.05647559463977814,
-0.11818644404411316,
-0.01102068368345499,
-0.13797399401664734,
0.1521781086921692,
0.2120899260044098,
0.14295679330825806,
0.009584040381014347,
-0.1343454271554947,
0.144249826669693,
0.33173495531082153,
-0.03773951902985573,
0.04491424560546875,
-0.1051139160990715,
0.23846860229969025,
-0.12478127330541611,
0.17231428623199463,
0.32151976227760315,
0.33902499079704285,
0.029821576550602913,
0.011859925463795662,
0.008385911583900452,
0.05315392091870308,
0.14696484804153442,
0.16364160180091858,
-0.03269258886575699,
0.09804358333349228,
-0.14343254268169403,
0.08744872361421585,
-0.11209213733673096,
-0.14835530519485474,
-0.02922331541776657,
0.06223214045166969,
0.05769713222980499,
-0.00655748276039958,
-0.1963346004486084,
0.2941650450229645,
0.1722654104232788,
0.0008984155720099807,
-0.13154852390289307,
-0.055087655782699585,
0.06445950269699097,
-0.14538182318210602,
0.10708221048116684,
0.3083621561527252,
-0.09912434220314026,
-0.08523412048816681,
0.10113923996686935,
0.271973192691803,
0.09805656224489212,
0.12190311402082443,
0.05720272287726402,
-0.11196332424879074,
-0.03818993270397186,
-0.02950921654701233,
-0.0197462011128664,
-0.08574820309877396,
-0.2756664752960205,
0.21464431285858154,
-0.2546861469745636,
0.31528493762016296,
-0.04536035656929016,
-0.1003112643957138,
-0.05935228243470192,
0.36591801047325134,
0.04349062591791153,
0.34986650943756104,
0.14156129956245422,
-0.1449713557958603,
0.09483959525823593,
0.015620730817317963,
0.08553862571716309,
0.06052723154425621,
-0.25483575463294983,
-0.1645611822605133,
0.1960327923297882,
0.044318798929452896,
0.17539261281490326,
-0.15970541536808014,
0.29776647686958313,
0.21150921285152435,
0.4278268814086914,
0.04273103177547455,
0.019719667732715607,
0.07298321276903152,
-0.33156609535217285,
0.0917215421795845,
-0.17072057723999023,
0.036910925060510635,
-0.24509291350841522,
0.05889629200100899,
0.16121433675289154,
-0.17054122686386108,
0.1011333093047142,
0.0889756828546524,
0.0757281631231308,
-0.1257481873035431,
-0.08226557821035385,
0.06289880722761154,
-0.09420706331729889,
-0.17494024336338043,
-0.14401333034038544,
-0.057765692472457886,
-0.13057130575180054,
0.07682552188634872,
-0.06735599786043167,
-0.11571790277957916,
0.006531441118568182,
-0.37371355295181274,
-0.0970076397061348,
0.10993777960538864,
-0.22163079679012299,
-0.28327181935310364,
-0.1773056536912918,
0.07593117654323578,
0.11098705977201462,
0.12007155269384384,
-0.2260727882385254,
0.14806808531284332,
0.12682309746742249,
0.1252519190311432,
0.08905736356973648,
0.17547790706157684,
-0.11927711963653564,
0.12924210727214813,
0.15506784617900848,
-0.05974455922842026,
-0.25308090448379517,
0.06843337416648865,
0.10062917321920395,
-0.07289876788854599,
-0.15782000124454498,
0.045178160071372986,
0.07726331055164337,
-0.010947161354124546,
-0.039578091353178024,
0.24581725895404816,
0.24154523015022278,
0.05750816687941551,
0.1795450747013092,
0.2738707661628723,
-0.20756736397743225,
0.14422601461410522,
-0.05405963957309723,
0.06242239475250244,
-0.12992028892040253,
0.3622645139694214,
0.08402258157730103,
-0.0024251630529761314,
0.05464465543627739,
-0.11824100464582443,
0.13583217561244965,
-0.0821540504693985,
0.13250163197517395,
0.10710260272026062,
-0.06233348697423935,
0.1043575257062912,
-0.2034803330898285,
0.21620075404644012,
-0.12595219910144806,
-0.1281309276819229,
0.0000041125827010546345,
0.19583018124103546,
0.11668593436479568,
-0.20186308026313782,
-0.016787096858024597,
-0.0347021222114563,
0.09821093827486038,
0.2530779242515564,
-0.022909194231033325,
0.014547951519489288,
0.07374143600463867,
0.03167417645454407,
0.13194672763347626,
-0.005961332004517317,
0.048522625118494034,
-0.2379152625799179,
0.06295175105333328,
-0.14860226213932037,
-0.2386401891708374,
-0.14719519019126892,
0.22924582660198212,
0.03323369473218918,
0.1772850751876831,
0.06965821236371994,
0.07821536064147949,
-0.13485349714756012,
-0.20996080338954926,
0.18437603116035461,
-0.3700803518295288,
0.04074520990252495,
-0.0809156745672226,
-0.10851568728685379,
0.06425098329782486,
0.13206520676612854,
-0.08386551588773727,
0.11060308665037155,
-0.1785997897386551,
0.12643441557884216,
0.10953265428543091,
-0.11561056971549988,
-0.014853229746222496,
0.014387141913175583,
0.3927498757839203,
0.003548775101080537,
0.06222030892968178,
0.010513479821383953,
0.3156125545501709,
-0.05043797194957733,
-0.11932595819234848,
-0.34853050112724304,
-0.11747534573078156,
-0.12270190566778183,
0.10510395467281342,
-0.13274864852428436,
0.003443940309807658,
-0.19250622391700745,
-0.1269170343875885,
0.07958943396806717,
-0.012349645607173443,
-0.09313230961561203,
0.01870388351380825,
0.1773773580789566,
-0.06383521854877472,
-0.08828984200954437,
-0.025086963549256325,
0.13845232129096985,
0.28951144218444824,
-0.14545652270317078,
-0.3045762777328491,
-0.1518276184797287,
0.22500313818454742,
0.1596376597881317,
-0.20050843060016632,
-0.3214312791824341,
0.0049385856837034225,
-0.062367118895053864,
-0.0997534915804863,
-0.029904905706644058,
0.06800450384616852,
-0.06982940435409546,
-0.056466180831193924,
-0.058087579905986786,
0.11128117889165878,
-0.03538767620921135,
0.029607029631733894,
0.07737769931554794,
-0.1732470691204071,
-0.42782872915267944,
-0.058854468166828156,
0.09852258116006851,
-0.06398982554674149,
0.11902119964361191,
0.11768082529306412,
-0.14022456109523773,
-0.06366930156946182,
0.08486010134220123,
0.15360525250434875,
0.03158805891871452,
-0.04863465204834938,
-0.1441056877374649,
0.008265972137451172,
-0.1804608255624771,
-0.43351230025291443,
-0.0374426394701004,
-0.13832013309001923,
0.24938079714775085,
0.18329234421253204,
-0.02106090635061264,
-0.12114188820123672,
-0.10161039978265762,
0.07686513662338257,
0.09464515000581741,
-0.18683180212974548,
-0.08509179204702377,
-0.04772987589240074,
-0.16299250721931458,
-0.11772416532039642,
0.15530698001384735,
0.08795452862977982,
-0.012067186646163464,
0.39581844210624695,
-0.03286917507648468,
-0.10770650207996368,
0.1393529772758484,
0.33317309617996216,
-0.04104071483016014,
0.03964224085211754,
0.10018764436244965,
0.09589889645576477,
-0.07499188929796219,
-0.09378668665885925,
0.19858278334140778,
0.1670403927564621,
0.34178319573402405,
0.10898573696613312,
-0.10049191117286682,
-0.05648786947131157,
-0.09156269580125809,
-0.11321495473384857,
0.05056930333375931,
-0.0028620848897844553,
-0.12089134007692337,
0.16476589441299438,
-0.08945080637931824,
-0.10211653262376785,
-0.15633194148540497,
-0.07898838818073273,
0.2330292910337448,
-0.08548613637685776,
-0.23791225254535675,
0.10775070637464523,
-0.04660544544458389,
0.277921587228775,
0.22891436517238617,
-0.21947336196899414,
0.13422593474388123,
0.2772064805030823,
-0.16539929807186127,
0.035115066915750504,
-0.2082149237394333,
0.04600132629275322,
-0.18859782814979553,
-0.1509975641965866,
0.19406579434871674,
0.08123305439949036,
-0.17133179306983948,
-0.21902145445346832,
0.21131470799446106,
0.11922188103199005,
0.4743235409259796,
-0.1717877984046936,
-0.12606510519981384,
-0.03351552039384842,
0.0483744740486145,
-0.25752049684524536,
0.05984092131257057,
-0.020750785246491432,
-0.1480671763420105,
-0.1699870526790619,
0.08778601139783859,
0.12613700330257416,
0.3162400722503662,
-0.004196696449071169,
-0.1409337967634201,
-0.08779784291982651,
-0.2655876576900482,
-0.15316422283649445,
0.21317079663276672,
-0.03308883681893349,
0.043291907757520676,
0.00904109701514244,
0.17819029092788696,
-0.28584882616996765,
0.0004070164868608117,
0.14281269907951355,
0.1429882049560547,
-0.039009276777505875,
0.29981109499931335,
0.2515360713005066,
0.11503428965806961,
-0.05878160893917084,
0.08813124895095825,
-0.012174258939921856,
0.011721021495759487,
0.006921755615621805,
0.1408184915781021,
0.1276550590991974,
0.09132028371095657,
0.09124952554702759,
-0.24160760641098022,
0.2744770646095276,
-0.00495609175413847,
0.0036329408176243305,
0.019370511174201965,
0.18773724138736725,
0.04562932625412941,
0.2663549482822418,
0.0836101546883583,
0.31074056029319763,
-0.1880180835723877,
0.06749983876943588,
0.06355316936969757,
-0.1732805073261261,
0.07349425554275513,
0.10616494715213776,
0.07873427122831345,
0.23935922980308533,
-0.17840780317783356,
0.0045097386464476585,
-0.11743423342704773,
-0.15979382395744324,
-0.14829766750335693,
0.2043406367301941,
-0.01685924455523491,
-0.07233038544654846,
0.24192757904529572,
0.13363975286483765,
0.14068280160427094,
0.14639870822429657,
-0.11155682802200317,
0.019020430743694305,
0.02397443726658821,
-0.20612777769565582,
0.07280992716550827,
-0.0928017720580101,
-0.22324229776859283,
-0.32571887969970703,
0.04180184006690979,
0.05399969965219498,
-0.07250271737575531,
0.1145591139793396,
0.106071837246418,
0.030789287760853767,
-0.0994093269109726,
0.030615322291851044,
0.23743659257888794,
-0.10790971666574478,
-0.13082854449748993,
-0.19216792285442352,
0.01681666262447834,
0.01525457575917244,
0.25398561358451843,
0.2400694191455841,
0.1097540482878685,
0.07747941464185715,
-0.07982033491134644,
0.02840542607009411,
0.06952417641878128,
-0.09232030063867569,
-0.06399551033973694,
0.038029301911592484,
0.16935864090919495,
-0.036112233996391296,
0.3327659070491791,
-0.10074625164270401,
-0.23573409020900726,
-0.031478989869356155,
-0.1422012746334076,
-0.06424303352832794,
-0.06880920380353928,
0.12556502223014832,
0.1373937875032425,
0.10102647542953491,
0.10169487446546555,
-0.1753690391778946,
0.1648937165737152,
-0.043403830379247665,
-0.18377061188220978,
0.13529933989048004,
-0.11677513271570206,
-0.26439204812049866,
-0.13873299956321716,
-0.053395826369524,
-0.20689259469509125,
0.18760399520397186,
-0.19748902320861816,
-0.2651745080947876,
0.1460077166557312,
0.19845767319202423,
-0.0025498520117253065,
0.17071905732154846,
0.05129633843898773,
0.04552696645259857,
0.17007197439670563,
0.14998562633991241,
-0.033649712800979614,
-0.1621168851852417,
-0.07329209893941879,
-0.16254442930221558,
0.057139940559864044,
0.12159246951341629,
0.13605345785617828,
0.23275986313819885,
-0.013280517421662807,
0.05852312967181206,
-0.16155479848384857,
-0.024628495797514915,
-0.023321904242038727,
-0.08261086046695709,
-0.06370007991790771,
-0.09465345740318298,
0.03934850916266441,
0.10855504870414734,
0.15582209825515747,
0.14232133328914642,
-0.010768339969217777,
0.31430870294570923,
0.0226320531219244,
-0.06979592144489288,
-0.14029471576213837,
-0.12920324504375458,
-0.013655676506459713,
-0.0470772422850132,
0.03267595171928406,
0.05367593467235565,
0.015704460442066193,
0.38899269700050354,
0.10530522465705872,
-0.17420734465122223,
-0.11244982481002808,
-0.04623176157474518,
0.13135914504528046,
0.31461456418037415,
0.21576108038425446,
-0.11567648500204086,
-0.16513153910636902,
-0.126509889960289,
-0.0746510922908783,
-0.28774377703666687,
0.23469242453575134,
0.20951686799526215,
0.17883561551570892,
0.12559035420417786,
0.033819977194070816,
-0.07190597802400589,
-0.030959442257881165,
0.08607754111289978,
-0.07418154925107956,
-0.22123120725154877,
0.0458509624004364,
0.009318423457443714,
-0.21857409179210663,
-0.16107751429080963,
-0.07795676589012146,
-0.03371895104646683,
-0.11786472797393799,
0.08735378831624985,
-0.0018474244279786944,
0.003695263061672449,
-0.16763891279697418,
-0.24344421923160553,
0.051739003509283066,
0.10518119484186172,
0.2359011471271515,
0.05853353068232536,
0.06798205524682999,
-0.04165077209472656,
-0.2176789939403534,
0.11539037525653839,
0.09761879593133926,
-0.08622144907712936,
0.09150008857250214,
0.008497949689626694,
-0.07377146929502487,
0.12890614569187164,
-0.017369233071804047,
-0.0011547537287697196,
-0.01781754568219185,
0.011691505089402199,
0.08317501842975616,
-0.24707244336605072,
-0.18399451673030853,
-0.19717709720134735,
-0.14337925612926483,
0.1628527194261551,
-0.06034078076481819,
-0.1221737265586853,
-0.1214730516076088,
0.3702082335948944,
-0.20678193867206573,
0.06172516942024231,
-0.20425443351268768,
-0.12526406347751617,
-0.07030607014894485,
-0.045593515038490295,
0.15345022082328796,
-0.0896458774805069,
-0.1345137357711792,
-0.17133492231369019,
-0.03372212126851082,
-0.13441947102546692,
-0.20117491483688354,
0.0711231604218483,
0.020480038598179817,
-0.1362120360136032,
0.21329832077026367,
0.12124231457710266,
0.08442800492048264,
0.005947626195847988,
-0.10443177074193954,
-0.06822804361581802,
0.09760904312133789,
-0.028158066794276237,
0.2444126009941101,
-0.10833737999200821,
-0.05839579552412033,
-0.0486333854496479,
-0.05491074174642563,
-0.03626159206032753,
0.21842913329601288,
-0.13204891979694366,
0.06823176890611649,
-0.1945493370294571,
0.06972368061542511,
0.0863710269331932,
-0.08971086144447327,
-0.2595828175544739,
0.09841248393058777,
0.13818322122097015,
0.24489426612854004,
-0.18338851630687714,
0.2329423427581787,
0.06389747560024261,
0.25146588683128357,
-0.12216105312108994,
-0.013624947518110275,
0.06400866061449051,
0.36885008215904236,
-0.15455715358257294,
0.04461979120969772,
-0.07026361674070358,
0.029162369668483734,
-0.19258885085582733,
0.18930907547473907,
0.06867535412311554,
0.17916002869606018,
-0.2817956209182739,
-0.16974520683288574,
0.07649678736925125,
0.24314938485622406,
-0.06096919625997543,
0.2034154236316681,
0.0564337857067585,
0.10387318581342697,
-0.07964850962162018,
-0.18153956532478333,
0.06895190477371216,
-0.2260524481534958,
-0.0002709022955968976,
-0.010077513754367828,
0.25771424174308777,
-0.021760592237114906,
-0.07038120180368423,
-0.1345892995595932,
0.08757387846708298,
-0.1519600749015808,
0.25361698865890503,
-0.17064613103866577,
0.3454357087612152,
-0.14810268580913544,
-0.02678927779197693,
-0.23313014209270477,
-0.12930859625339508,
0.016997605562210083,
-0.07800253480672836,
-0.07758022844791412,
0.05947853624820709,
-0.0050407880917191505,
-0.015497258864343166,
0.15824930369853973,
-0.07210268080234528,
0.14389462769031525,
-0.19826987385749817,
0.0779612734913826,
-0.04984353110194206,
0.09746454656124115,
-0.012849532067775726,
-0.04597577452659607,
0.009099436923861504,
0.1890108734369278,
-0.24998725950717926,
0.09049014747142792,
-0.23925745487213135,
0.011716446839272976,
0.16630986332893372,
-0.20292773842811584,
-0.022462323307991028,
-0.0016642491100355983,
-0.10110311955213547,
-0.10428649187088013,
-0.1230974793434143,
0.05602625757455826,
0.3128003180027008,
0.03266230225563049,
-0.2862619161605835,
-0.15251104533672333,
-0.11452958732843399,
0.09270647913217545,
0.23583880066871643,
0.15296584367752075,
-0.005710168741643429,
0.08546020835638046,
-0.19441072642803192,
-0.1775120347738266,
-0.05462677404284477,
0.0581759549677372,
0.07960902899503708,
-0.05097617954015732,
-0.20319055020809174,
0.44047659635543823,
0.06511056423187256,
0.10872874408960342,
-0.21481797099113464,
0.01989464834332466,
0.06726931035518646,
-0.06784122437238693,
0.1495104432106018,
0.09720513969659805,
0.13038426637649536,
0.12656787037849426,
-0.04479322209954262,
-0.2092599868774414,
-0.1026332825422287,
-0.04534780606627464,
-0.00904777180403471,
0.14225685596466064,
0.2337847352027893,
-0.033835578709840775,
0.4108639657497406,
-0.06241369619965553,
-0.1516236960887909,
-0.04360952228307724,
0.021850377321243286,
-0.05445633456110954,
-0.06434740126132965,
-0.0036342372186481953,
-0.03563517704606056,
-0.005230889655649662,
0.10976892709732056,
-0.1582886427640915,
0.27567410469055176,
0.27826666831970215,
-0.06829456984996796,
-0.2493884563446045,
-0.1384085863828659,
-0.1039826050400734,
-0.011165875010192394,
-0.143330916762352,
0.031874530017375946,
0.059118784964084625,
-0.08624524623155594,
-0.00328368810005486,
0.023164400830864906,
0.06357402354478836,
0.23397907614707947,
0.08508697897195816,
-0.007345434278249741,
0.04628948122262955,
0.2121691107749939,
-0.10047488659620285,
-0.18260549008846283,
-0.05635075643658638,
-0.10072994232177734,
0.1527094691991806,
0.2555583417415619,
0.030392296612262726,
0.19285783171653748,
-0.06003301963210106,
0.04601612687110901,
-0.0057602254673838615,
-0.12158714979887009,
0.07501654326915741,
0.017877425998449326,
-0.0819389596581459,
-0.05052956938743591,
-0.02662535570561886,
-0.099603071808815,
-0.08225757628679276,
0.03164729103446007,
-0.08716230094432831,
-0.05275384709239006
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. .In individuals with prolidase deficiency imidodipeptiduria has been detected as early as in the newborn period, even in the absence of signs or symptoms of the disease. (This finding has been used as the basis for urinary newborn screening in Quebec .)Under normal circumstances the urinary excretion of glycylproline is negligible ; thus, the absence of detectable imidodipeptiduria in properly processed samples is sufficient evidence to rule out a diagnosis of prolidase deficiency .Click here (pdf) for information on laboratory methods used to detect imidodipeptiduria.Other biochemical findings:The concentration of imidodipeptides is much lower in serum than urine .Gly-Pro has been reported in the plasma by some investigators , but not others .CSF amino acid analysis was normal in the first report of probable prolidase deficiency .*Note: A number of published reports mistakenly refer to imidodipeptiduria as "iminodipe | [
-0.04552021995186806,
0.2104821503162384,
-0.11919379979372025,
-0.1855906844139099,
0.04113191366195679,
0.21007168292999268,
-0.009327702224254608,
-0.10945673286914825,
0.040189649909734726,
-0.09071790426969528,
0.15771515667438507,
0.30453360080718994,
0.14019447565078735,
0.04419150948524475,
-0.09201409667730331,
0.11377197504043579,
0.29737281799316406,
-0.10803920775651932,
0.04700803384184837,
-0.055553968995809555,
0.22346588969230652,
-0.18623347580432892,
0.18187397718429565,
0.18010227382183075,
0.30659300088882446,
0.0312943272292614,
0.05071689188480377,
0.015055113472044468,
0.11792043596506119,
0.15848271548748016,
-0.016767451539635658,
-0.004099132493138313,
0.0829119086265564,
-0.12063276022672653,
0.09128593653440475,
-0.1407972276210785,
-0.1380118578672409,
0.06164981797337532,
0.14644020795822144,
0.0067094056867063046,
0.006425357889384031,
-0.09126076102256775,
0.24785451591014862,
0.04689772427082062,
0.08666636794805527,
-0.0349719375371933,
-0.03365601599216461,
0.09927196800708771,
-0.11982769519090652,
0.11399964988231659,
0.2611440122127533,
-0.06766313314437866,
0.0035234016831964254,
0.04804975166916847,
0.2891262173652649,
0.15635764598846436,
0.22175000607967377,
0.039520878344774246,
-0.19721291959285736,
0.04204889386892319,
0.06021711975336075,
-0.08057431876659393,
-0.06854031980037689,
-0.35462403297424316,
0.1558423787355423,
-0.17525923252105713,
0.27729278802871704,
-0.07632525265216827,
-0.05334204062819481,
-0.014609911479055882,
0.2962229251861572,
0.04322611168026924,
0.3612985610961914,
0.11269555240869522,
-0.12078201770782471,
0.07830708473920822,
0.07160342484712601,
0.10780499130487442,
-0.0055247037671506405,
-0.2562902569770813,
-0.23869599401950836,
0.14209195971488953,
0.04507489502429962,
0.16447561979293823,
-0.1555149108171463,
0.18713515996932983,
0.11819738149642944,
0.40705573558807373,
-0.04578425735235214,
0.11987226456403732,
0.07562285661697388,
-0.25038644671440125,
0.06819097697734833,
-0.18193264305591583,
0.09514396637678146,
-0.22295187413692474,
0.1044459342956543,
0.18707087635993958,
-0.19094626605510712,
0.09756908565759659,
0.09653681516647339,
0.11408348381519318,
-0.09595383703708649,
-0.09827244281768799,
0.06639891117811203,
-0.030900200828909874,
-0.14183831214904785,
-0.21784763038158417,
0.059143513441085815,
-0.15048648416996002,
0.010415077209472656,
-0.12192219495773315,
-0.08449501544237137,
-0.006824375130236149,
-0.2757623791694641,
-0.022038010880351067,
0.21053995192050934,
-0.16288021206855774,
-0.19053611159324646,
-0.09042590856552124,
-0.04398893937468529,
0.05158087983727455,
0.11805785447359085,
-0.1745489090681076,
0.16813547909259796,
0.09190557897090912,
0.16429738700389862,
0.023351255804300308,
0.2294163554906845,
-0.0982552170753479,
0.06827735900878906,
0.13767971098423004,
-0.054451413452625275,
-0.19017180800437927,
0.039065368473529816,
0.030114881694316864,
-0.15580247342586517,
-0.12369820475578308,
-0.03287793695926666,
0.0753612220287323,
0.01711491495370865,
-0.03271465748548508,
0.2898007333278656,
0.2185208648443222,
0.021841205656528473,
0.18954519927501678,
0.25761720538139343,
-0.1679127961397171,
0.26722750067710876,
-0.027884576469659805,
0.05223538354039192,
-0.08267350494861603,
0.3161895275115967,
0.12379807233810425,
-0.017784778028726578,
0.02927015908062458,
-0.09098529070615768,
0.13184711337089539,
-0.09077074378728867,
0.1487063467502594,
0.05657319724559784,
-0.021427135914564133,
0.11794121563434601,
-0.1810857355594635,
0.1147235855460167,
-0.11195681989192963,
-0.16703125834465027,
0.06595131754875183,
0.06445091962814331,
0.06469551473855972,
-0.2074735462665558,
0.08074066787958145,
-0.10258176177740097,
0.041880276054143906,
0.21759597957134247,
-0.060716334730386734,
0.04597340524196625,
0.03574476018548012,
-0.001970360754057765,
0.14995430409908295,
0.016412895172834396,
0.03209392726421356,
-0.12432344257831573,
0.14865444600582123,
-0.15948496758937836,
-0.20373933017253876,
-0.038147635757923126,
0.2995617985725403,
0.0788235068321228,
0.17150186002254486,
0.033639196306467056,
0.14301306009292603,
-0.06300055235624313,
-0.1243559941649437,
0.1394222229719162,
-0.2993381917476654,
0.08951917290687561,
-0.1296127736568451,
-0.1314937025308609,
-0.031109949573874474,
0.11752066016197205,
-0.09557533264160156,
0.14557220041751862,
-0.17107722163200378,
0.09024376422166824,
0.11251413077116013,
-0.01048454362899065,
-0.05535266175866127,
-0.04118627309799194,
0.2864263653755188,
-0.10717354714870453,
0.0811857208609581,
0.03129494562745094,
0.24406912922859192,
-0.13368184864521027,
-0.08060925453901291,
-0.17871113121509552,
-0.04836004599928856,
-0.10078614205121994,
0.09123894572257996,
-0.14586281776428223,
-0.005046456586569548,
-0.2687905728816986,
-0.08963899314403534,
0.043875206261873245,
0.018463019281625748,
-0.03423251211643219,
-0.02014741487801075,
0.10647855699062347,
-0.09274658560752869,
-0.07275639474391937,
0.038860879838466644,
0.20033474266529083,
0.24070453643798828,
-0.13015198707580566,
-0.2791270315647125,
-0.10149163007736206,
0.2147941142320633,
0.06986355036497116,
-0.10914012044668198,
-0.29858294129371643,
-0.005542227532714605,
0.03616679832339287,
-0.11672694981098175,
-0.06677862256765366,
0.00942416675388813,
-0.03641710430383682,
-0.016779916360974312,
-0.0019180587260052562,
0.12825138866901398,
-0.0807667225599289,
0.07865575700998306,
0.08710535615682602,
-0.13349522650241852,
-0.4162723124027252,
-0.07394447922706604,
0.03602246940135956,
-0.09597860276699066,
0.14346681535243988,
0.23111136257648468,
-0.11421342194080353,
-0.015687227249145508,
0.08584391325712204,
0.03521129488945007,
0.01078734826296568,
-0.07086566835641861,
-0.16043388843536377,
-0.02748281881213188,
-0.14288465678691864,
-0.3397350609302521,
-0.07024867087602615,
-0.04143432900309563,
0.1869109869003296,
0.13297314941883087,
-0.010162035003304482,
-0.09617194533348083,
-0.025661304593086243,
0.1110125258564949,
0.02466282621026039,
-0.2727578282356262,
-0.022052451968193054,
0.0545881949365139,
-0.1700173318386078,
-0.18160638213157654,
0.20232591032981873,
0.1592816859483719,
0.06744898110628128,
0.3597474694252014,
-0.1302606463432312,
-0.022248074412345886,
0.18931108713150024,
0.328291118144989,
-0.10324312001466751,
-0.12777303159236908,
0.06340008229017258,
0.07705783098936081,
-0.06411392241716385,
0.0028058181051164865,
0.1633017212152481,
0.06876257061958313,
0.33176594972610474,
0.07810922712087631,
0.01630530133843422,
-0.0841873288154602,
-0.09956898540258408,
-0.09759829938411713,
0.013873381540179253,
-0.0813075378537178,
-0.10916867107152939,
0.14743031561374664,
-0.14841274917125702,
-0.13392044603824615,
-0.12236016988754272,
-0.10177994519472122,
0.19984522461891174,
-0.04211193695664406,
-0.2427864521741867,
0.04299471899867058,
-0.04436098411679268,
0.22865651547908783,
0.22122114896774292,
-0.13634827733039856,
0.07136418670415878,
0.2106751799583435,
-0.14450296759605408,
-0.016068555414676666,
-0.19977331161499023,
0.09086935222148895,
-0.10718610137701035,
-0.18782538175582886,
0.20378659665584564,
0.09936559200286865,
-0.12747786939144135,
-0.28855255246162415,
0.15683972835540771,
0.12464167177677155,
0.3809066414833069,
-0.1500965803861618,
-0.24698074162006378,
-0.018761401996016502,
0.07236967235803604,
-0.23518605530261993,
0.09484432637691498,
-0.03748524188995361,
-0.06347212940454483,
-0.07171570509672165,
0.07990067452192307,
0.0771542638540268,
0.28565356135368347,
-0.091562919318676,
-0.11847050487995148,
0.011462904512882233,
-0.12097776681184769,
-0.15036895871162415,
0.22180962562561035,
-0.07294784486293793,
-0.05885891988873482,
0.09705542773008347,
0.2209162563085556,
-0.19062303006649017,
-0.12814943492412567,
0.17012161016464233,
0.201063334941864,
-0.1525939702987671,
0.24549610912799835,
0.1366443932056427,
0.14375831186771393,
-0.001823517377488315,
0.11382380872964859,
0.056848857551813126,
0.037673577666282654,
0.023259015753865242,
0.05966057628393173,
0.11654464900493622,
-0.03304383158683777,
0.12410859763622284,
-0.17635996639728546,
0.2382064014673233,
0.02757978066802025,
-0.0834478810429573,
-0.003746556816622615,
0.08347319066524506,
0.020098280161619186,
0.2341693490743637,
0.06600631773471832,
0.2138451486825943,
-0.24515900015830994,
0.10499677807092667,
0.08611395955085754,
-0.11218590289354324,
0.07438406348228455,
0.09106042981147766,
0.06038375943899155,
0.15859399735927582,
-0.10273171961307526,
0.09237232804298401,
-0.1606651246547699,
-0.17287002503871918,
-0.19119423627853394,
0.192041277885437,
0.07916213572025299,
-0.04471538960933685,
0.19941508769989014,
0.15301749110221863,
0.02628745138645172,
0.1035374328494072,
-0.07270736247301102,
0.1048169881105423,
0.03457918018102646,
-0.17787693440914154,
0.11586722731590271,
-0.004603068809956312,
-0.1359405517578125,
-0.23388607800006866,
0.04388250783085823,
0.018682237714529037,
-0.10264475643634796,
0.06226860359311104,
0.09198459982872009,
0.07232271134853363,
-0.17792655527591705,
-0.003094955813139677,
0.23399096727371216,
-0.07032492756843567,
-0.125890851020813,
-0.18652814626693726,
-0.016502689570188522,
-0.030799604952335358,
0.2117917239665985,
0.3272395431995392,
0.19044139981269836,
0.03565451502799988,
-0.04885327070951462,
-0.018701612949371338,
0.015254948288202286,
-0.03277546167373657,
0.05042129009962082,
-0.024565359577536583,
0.11895086616277695,
-0.00422249548137188,
0.3196837604045868,
-0.13568426668643951,
-0.19929596781730652,
-0.049744199961423874,
-0.23794685304164886,
0.013143403455615044,
-0.03832349181175232,
0.08530721813440323,
0.08413691818714142,
0.12773212790489197,
0.0070419833064079285,
-0.05022650584578514,
0.1633453369140625,
0.00888859387487173,
-0.18165171146392822,
0.08061261475086212,
-0.14918285608291626,
-0.03806048259139061,
-0.07381391525268555,
-0.062830850481987,
-0.11914874613285065,
0.2296353280544281,
-0.1763652265071869,
-0.22057123482227325,
0.08519347757101059,
0.17978160083293915,
-0.07493399828672409,
0.18199823796749115,
0.014983361586928368,
-0.029082203283905983,
0.1590970903635025,
0.09123058617115021,
-0.04895482957363129,
-0.16069558262825012,
-0.09624183923006058,
-0.1600848138332367,
-0.06288987398147583,
0.06659208983182907,
0.03309129923582077,
0.14423079788684845,
-0.02390935644507408,
-0.018558744341135025,
-0.12208570539951324,
0.05505416914820671,
-0.07437307387590408,
-0.03631378710269928,
-0.09880830347537994,
-0.06902241706848145,
-0.019734838977456093,
0.14189982414245605,
0.145907923579216,
0.1477857530117035,
0.019592586904764175,
0.26626572012901306,
0.016933929175138474,
-0.17664283514022827,
-0.1094619557261467,
-0.12852665781974792,
-0.019087543711066246,
-0.06778199225664139,
0.06535443663597107,
0.045634675770998,
0.03367570415139198,
0.32202404737472534,
0.03078797087073326,
-0.18427367508411407,
-0.12684334814548492,
-0.04168334975838661,
0.08505374193191528,
0.25081953406333923,
0.23536834120750427,
-0.06838435679674149,
-0.18525207042694092,
-0.05997532978653908,
-0.11092715710401535,
-0.21134062111377716,
0.20058725774288177,
0.13187465071678162,
0.15941017866134644,
0.020948057994246483,
0.031817737966775894,
-0.047918546944856644,
0.06634515523910522,
0.08167025446891785,
0.07195624709129333,
-0.18536143004894257,
0.06681900471448898,
0.033563945442438126,
-0.16062131524085999,
-0.14065787196159363,
0.010288723744452,
-0.03753094747662544,
-0.10489438474178314,
0.14691072702407837,
0.009309863671660423,
0.06254827976226807,
-0.20699161291122437,
-0.23961079120635986,
0.07108312100172043,
0.013989732600748539,
0.12457511574029922,
0.08701343834400177,
0.06774844229221344,
-0.01386906299740076,
-0.14544732868671417,
0.23241397738456726,
0.15997518599033356,
-0.1300094872713089,
0.0866551473736763,
0.02555892989039421,
-0.06303868442773819,
0.15430758893489838,
0.07988741993904114,
0.016112010926008224,
-0.09187396615743637,
0.007012560497969389,
0.043813079595565796,
-0.18438905477523804,
-0.1662093847990036,
-0.0974356159567833,
-0.09957931190729141,
0.17378723621368408,
0.009791812859475613,
-0.14059460163116455,
-0.10499893128871918,
0.34941214323043823,
-0.07068271189928055,
0.05053127929568291,
-0.06243725121021271,
-0.1239655390381813,
0.0013801127206534147,
-0.08574528992176056,
-0.00015878946578595787,
-0.10144621133804321,
-0.14642168581485748,
-0.11441230773925781,
-0.11329907178878784,
-0.09184985607862473,
-0.16792522370815277,
0.13140425086021423,
-0.025978852063417435,
-0.20354288816452026,
0.0889458879828453,
0.09977461397647858,
0.03370112180709839,
-0.01155253779143095,
-0.1066911518573761,
-0.11735296994447708,
0.13332512974739075,
-0.01069883443415165,
0.20437297224998474,
-0.03088226355612278,
-0.042211707681417465,
-0.010644476860761642,
0.09060430526733398,
-0.07390300929546356,
0.20587991178035736,
-0.07558515667915344,
0.06425003707408905,
-0.12649711966514587,
-0.0328856036067009,
0.03839863836765289,
-0.08804813772439957,
-0.26948705315589905,
0.074378602206707,
0.04606040567159653,
0.14725473523139954,
-0.23061995208263397,
0.2260318398475647,
0.08988643437623978,
0.2737487256526947,
-0.08222551643848419,
-0.023178668692708015,
0.0661458969116211,
0.3291270434856415,
-0.046418093144893646,
0.03069581836462021,
-0.10278873890638351,
0.05023377761244774,
-0.15351782739162445,
0.18883392214775085,
0.11701729893684387,
0.18265660107135773,
-0.28189167380332947,
-0.15609142184257507,
0.07355119287967682,
0.1740269958972931,
-0.06630366295576096,
0.1636432260274887,
0.0567791573703289,
0.07494049519300461,
-0.024301832541823387,
-0.14940258860588074,
0.09570536017417908,
-0.12367276847362518,
0.07158811390399933,
-0.017423823475837708,
0.2622886896133423,
-0.010779903270304203,
-0.10476299375295639,
-0.038396719843149185,
0.04142870754003525,
-0.19397510588169098,
0.2826816737651825,
-0.2133478820323944,
0.333738774061203,
-0.20691922307014465,
0.050326116383075714,
-0.1175522431731224,
-0.1594061404466629,
-0.01870780996978283,
-0.052016500383615494,
-0.1858290135860443,
0.08384533226490021,
0.04440857842564583,
-0.010197442956268787,
0.08004018664360046,
-0.053562041372060776,
0.17555354535579681,
-0.1647399216890335,
-0.0028280599508434534,
-0.03058193065226078,
0.10041389614343643,
-0.019031768664717674,
0.005621424876153469,
0.07546143233776093,
0.2472425103187561,
-0.07822606712579727,
0.015715086832642555,
-0.2050713747739792,
-0.004469487816095352,
0.199960395693779,
-0.17995600402355194,
-0.022803761065006256,
-0.010693510062992573,
-0.14308671653270721,
-0.13133442401885986,
-0.23690293729305267,
0.03952471539378166,
0.2793722450733185,
0.03753969073295593,
-0.23186086118221283,
-0.13129572570323944,
-0.190464049577713,
0.10417637974023819,
0.13044802844524384,
0.15556110441684723,
-0.022445805370807648,
0.17116309702396393,
-0.14110586047172546,
-0.09520076215267181,
-0.09160088747739792,
0.1157912164926529,
0.04963717609643936,
-0.025128649547696114,
-0.045663945376873016,
0.4123130738735199,
-0.07321739196777344,
0.028823303058743477,
-0.1684032827615738,
-0.026680180802941322,
0.0916418507695198,
-0.04789605736732483,
0.1448134034872055,
0.047421637922525406,
0.08604924380779266,
0.0795779675245285,
-0.0289293322712183,
-0.18769484758377075,
-0.15602147579193115,
-0.05971700698137283,
-0.026987947523593903,
0.04074254259467125,
0.20296667516231537,
-0.056833408772945404,
0.261273592710495,
-0.08411362022161484,
-0.08644174784421921,
-0.010955226607620716,
-0.021455785259604454,
-0.10919179767370224,
-0.14219434559345245,
-0.07069172710180283,
-0.14022856950759888,
0.03741776570677757,
0.15408113598823547,
-0.209161639213562,
0.19253773987293243,
0.24638766050338745,
-0.09435473382472992,
-0.18776771426200867,
-0.03630589321255684,
-0.22273331880569458,
-0.04956579580903053,
-0.014861702919006348,
0.017086340114474297,
0.07508395612239838,
-0.04112918674945831,
-0.03388746455311775,
-0.04574333503842354,
0.1758635938167572,
0.1476915031671524,
0.05938081070780754,
-0.042144156992435455,
0.06127562001347542,
0.11691562086343765,
-0.07971532642841339,
-0.10107752680778503,
-0.038624122738838196,
-0.018383197486400604,
0.17145076394081116,
0.20796462893486023,
-0.038938071578741074,
0.22663390636444092,
-0.010265979915857315,
0.0797596275806427,
-0.05516313016414642,
-0.1632409542798996,
0.1617783159017563,
-0.013760213740170002,
-0.05914526805281639,
-0.08536341786384583,
-0.06854989379644394,
-0.1205865740776062,
-0.12491369992494583,
0.03255097568035126,
-0.10423889756202698,
-0.09452813863754272
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. deficiency .Click here (pdf) for information on laboratory methods used to detect imidodipeptiduria.Other biochemical findings:The concentration of imidodipeptides is much lower in serum than urine .Gly-Pro has been reported in the plasma by some investigators , but not others .CSF amino acid analysis was normal in the first report of probable prolidase deficiency .*Note: A number of published reports mistakenly refer to imidodipeptiduria as "iminodipeptiduria." Iminodipeptides are dipeptides in which proline or hydroxyproline is the N-terminal amino acid (i.e., Pro/Hyp-X, for example prolylglycine), whereas imidodipeptides are dipeptides in which proline or hydroxyproline is the C-terminal amino acid (i.e., X-Pro/Hyp, for example glycylproline).Establishing the DiagnosisThe diagnosis of prolidase deficiency | [
-0.11768031120300293,
0.2043483555316925,
-0.28270938992500305,
-0.08892856538295746,
0.07695991545915604,
0.1047876849770546,
-0.03546551614999771,
-0.03706328570842743,
0.17261038720607758,
-0.07908347994089127,
0.30926886200904846,
0.30456721782684326,
0.12497956305742264,
0.06448008120059967,
-0.20730185508728027,
0.0033866320736706257,
0.31356242299079895,
-0.1436913162469864,
-0.040476907044649124,
0.08442571759223938,
0.22806167602539062,
-0.007765439338982105,
0.1717931032180786,
0.21332614123821259,
0.29525256156921387,
0.10867580026388168,
-0.09669347107410431,
0.06666186451911926,
0.107943594455719,
-0.2078648805618286,
-0.23142923414707184,
0.1282835751771927,
0.10457957535982132,
-0.2498011589050293,
0.29876086115837097,
-0.19214755296707153,
-0.2635446786880493,
0.2455642968416214,
0.0627443864941597,
0.07575474679470062,
0.03302547708153725,
-0.22609806060791016,
0.11309124529361725,
0.09413982182741165,
0.029537275433540344,
-0.0327816903591156,
-0.11426991969347,
0.11758752167224884,
-0.1721792072057724,
0.11447913199663162,
0.1553131341934204,
0.01039074081927538,
-0.1286301463842392,
0.033566780388355255,
0.2776813805103302,
0.11475900560617447,
0.2427341789007187,
0.028747055679559708,
-0.08510597050189972,
-0.03927453234791756,
-0.07708752155303955,
-0.08881928026676178,
-0.08160357922315598,
-0.29098907113075256,
0.024593248963356018,
-0.12827342748641968,
0.28533583879470825,
-0.1209464743733406,
-0.1361662596464157,
-0.016716502606868744,
0.3516300916671753,
-0.27013930678367615,
0.2747412323951721,
0.28113511204719543,
-0.21117383241653442,
-0.22137606143951416,
0.11924745887517929,
0.014945472590625286,
0.053266026079654694,
-0.2502322793006897,
-0.2826070189476013,
0.35239171981811523,
0.10806304961442947,
0.22245092689990997,
-0.29459357261657715,
0.2396174967288971,
0.030939683318138123,
0.22559325397014618,
-0.052694931626319885,
0.13199949264526367,
0.12089647352695465,
-0.1520071029663086,
0.04759424552321434,
-0.056586574763059616,
0.1987113356590271,
-0.11558793485164642,
0.1327841430902481,
0.17343004047870636,
-0.28073883056640625,
0.29634523391723633,
-0.03931856155395508,
0.13689440488815308,
-0.31450170278549194,
-0.013738362118601799,
0.045396991074085236,
-0.04833849519491196,
-0.14410963654518127,
-0.32904917001724243,
0.05025358125567436,
-0.1436392366886139,
0.025833148509263992,
0.013438661582767963,
-0.20963993668556213,
-0.019311053678393364,
-0.3740779757499695,
-0.08446293324232101,
0.3714655041694641,
-0.18989014625549316,
-0.16104727983474731,
-0.07402591407299042,
0.004241247195750475,
0.25825318694114685,
0.04096414893865585,
-0.09614075720310211,
0.33507171273231506,
0.18732602894306183,
0.2628379464149475,
0.07686147093772888,
0.31474846601486206,
-0.009020531550049782,
-0.010506669990718365,
0.0052887755446136,
0.0842345580458641,
-0.09947636723518372,
0.05677274242043495,
0.1318131387233734,
-0.1220775693655014,
-0.03541410341858864,
-0.08340079337358475,
0.1555919200181961,
-0.08482575416564941,
-0.1095634251832962,
0.14782212674617767,
0.14187614619731903,
0.030239399522542953,
0.08736749738454819,
0.2407722771167755,
-0.225028857588768,
0.25821107625961304,
-0.03058447130024433,
0.15345986187458038,
-0.024601398035883904,
0.02681167609989643,
0.005660626571625471,
0.2824553847312927,
0.14463797211647034,
-0.25159743428230286,
0.1266326904296875,
-0.07043053209781647,
0.14683479070663452,
0.04345875605940819,
-0.09126821905374527,
0.15143175423145294,
-0.29208627343177795,
0.23415948450565338,
-0.1949024498462677,
-0.27334266901016235,
0.03176620602607727,
0.07363490760326385,
-0.001383129507303238,
-0.22623185813426971,
0.02087516523897648,
-0.04031830653548241,
0.013073218986392021,
0.3393067419528961,
-0.12510715425014496,
0.09027945250272751,
0.07809869199991226,
-0.07563550770282745,
0.15828827023506165,
0.05999676138162613,
0.07973876595497131,
-0.03244256600737572,
0.30063799023628235,
-0.037833306938409805,
-0.09254082292318344,
-0.09934806823730469,
0.36111128330230713,
0.12354961037635803,
0.3623306155204773,
0.2601725161075592,
0.15762491524219513,
-0.04068009555339813,
-0.1849711686372757,
0.10320279002189636,
-0.28501227498054504,
0.301950603723526,
-0.10262598842382431,
0.1851600855588913,
-0.024796616286039352,
0.3235445022583008,
-0.04889591038227081,
0.1549004167318344,
-0.07802098989486694,
0.2665921449661255,
0.07601290941238403,
0.12226671725511551,
-0.017152100801467896,
-0.03426358103752136,
0.3866822123527527,
0.04605865851044655,
0.02752370946109295,
-0.020355617627501488,
0.27655431628227234,
-0.10146225988864899,
0.03366948664188385,
-0.2850518822669983,
0.023813413456082344,
-0.14732444286346436,
-0.06233283504843712,
-0.12680409848690033,
-0.18269473314285278,
-0.1057528555393219,
-0.07797535508871078,
0.11819679290056229,
-0.20823247730731964,
0.03561300039291382,
-0.15661416947841644,
0.11883609741926193,
-0.10925211757421494,
-0.19252334535121918,
0.04344402626156807,
0.4157077670097351,
0.20963284373283386,
-0.09745699167251587,
-0.20502355694770813,
-0.1724318414926529,
0.043036866933107376,
-0.2335054874420166,
-0.0549430325627327,
-0.28867286443710327,
0.12192993611097336,
-0.024188624694943428,
-0.04162650555372238,
-0.07497557252645493,
-0.08008038997650146,
-0.055639173835515976,
0.009457054547965527,
0.1262557953596115,
0.2215825319290161,
-0.041722722351551056,
0.03849465399980545,
0.11394213140010834,
-0.08455157279968262,
-0.34547847509384155,
0.05179982632398605,
-0.06596388667821884,
-0.1680368036031723,
0.0893179401755333,
0.1866409033536911,
-0.18344800174236298,
0.052499160170555115,
-0.045528024435043335,
0.05602259933948517,
-0.09867197275161743,
-0.07891306281089783,
-0.10090329498052597,
-0.03258685767650604,
0.09241057187318802,
-0.2574976980686188,
0.07058632373809814,
-0.0751611739397049,
0.23840562999248505,
0.07260322570800781,
-0.06007057800889015,
-0.1176711916923523,
-0.003361138980835676,
0.08296117931604385,
0.035148635506629944,
-0.3991750180721283,
-0.0258997343480587,
0.24001997709274292,
-0.15936335921287537,
-0.3625105917453766,
0.09398669004440308,
0.12694452702999115,
-0.10302723944187164,
0.3114495277404785,
-0.050193410366773605,
-0.05344868451356888,
0.12566116452217102,
0.14672455191612244,
0.0004083261010237038,
-0.1506456434726715,
-0.15350762009620667,
-0.04991229623556137,
0.002787860343232751,
-0.0089386822655797,
0.037632014602422714,
-0.13501836359500885,
0.2574225068092346,
0.15566307306289673,
0.06648856401443481,
0.05837465450167656,
-0.37472477555274963,
-0.2828420400619507,
-0.0071219028905034065,
0.026306379586458206,
-0.18732689321041107,
-0.004282435402274132,
-0.13810473680496216,
-0.025086617097258568,
-0.15999631583690643,
-0.07579232007265091,
0.25512635707855225,
0.006008314900100231,
-0.22924967110157013,
-0.054554909467697144,
-0.1005757749080658,
0.044731151312589645,
0.25537437200546265,
-0.31367236375808716,
0.055292773991823196,
0.25347065925598145,
-0.05504615232348442,
0.018414629623293877,
-0.06817829608917236,
-0.13704507052898407,
0.0979609340429306,
-0.0976838693022728,
0.006491795647889376,
0.10225577652454376,
0.027319500222802162,
-0.19266271591186523,
0.060697611421346664,
-0.11351937800645828,
0.46745842695236206,
0.026574214920401573,
-0.10490197688341141,
-0.12617217004299164,
-0.008123038336634636,
-0.5776380896568298,
0.1487097591161728,
-0.07342273741960526,
-0.016846789047122,
-0.005687142722308636,
0.10168205946683884,
0.2130807489156723,
0.4820109009742737,
-0.17169123888015747,
-0.3468107283115387,
0.01193977054208517,
0.021368158981204033,
-0.017767751589417458,
0.028690777719020844,
-0.010561254806816578,
-0.12495361268520355,
0.1644981950521469,
0.30805766582489014,
-0.09612208604812622,
-0.10581320524215698,
0.04134918749332428,
-0.028660036623477936,
0.015328464098274708,
0.05478033423423767,
0.3141559958457947,
-0.02398279495537281,
0.029907692223787308,
0.17540867626667023,
0.14611761271953583,
0.020858919247984886,
0.13424654304981232,
0.17498573660850525,
0.11116259545087814,
-0.14440645277500153,
0.0317353792488575,
-0.40362703800201416,
0.052585165947675705,
0.19307810068130493,
0.0155907878652215,
-0.028485676273703575,
0.1223221868276596,
0.0869796946644783,
0.23210039734840393,
-0.04719063267111778,
0.22465772926807404,
-0.2431754618883133,
0.24319611489772797,
0.012556192465126514,
-0.14234887063503265,
0.24415388703346252,
0.06526292115449905,
-0.16718795895576477,
0.14143157005310059,
-0.2705329656600952,
0.17242327332496643,
-0.06120840460062027,
-0.13660767674446106,
-0.2627882957458496,
0.21371690928936005,
0.01645766943693161,
0.06434354186058044,
0.3263602554798126,
0.004347583279013634,
0.15148696303367615,
0.25308504700660706,
0.024600548669695854,
0.12178146094083786,
0.03125692531466484,
0.028123505413532257,
0.06524913012981415,
0.015574808232486248,
-0.005398094654083252,
-0.1603059470653534,
0.01177910901606083,
0.08061304688453674,
-0.14687460660934448,
0.33430173993110657,
0.17445801198482513,
0.11571666598320007,
-0.24144423007965088,
-0.01142179500311613,
0.1061561182141304,
-0.016934918239712715,
-0.1684458702802658,
-0.2103172242641449,
0.02528359927237034,
-0.06768016517162323,
0.1510288417339325,
0.2802131772041321,
0.12766684591770172,
0.1822959929704666,
-0.10250808298587799,
0.07067731767892838,
0.06318642199039459,
-0.12838707864284515,
0.03849447891116142,
-0.04280153289437294,
0.16775886714458466,
0.03949923813343048,
0.48828181624412537,
-0.24465160071849823,
-0.3716675341129303,
-0.131277397274971,
-0.09039513766765594,
-0.01611253432929516,
-0.1255442500114441,
-0.04905255138874054,
0.10300100594758987,
0.07267605513334274,
0.10504589974880219,
0.053448185324668884,
0.266666054725647,
0.12774166464805603,
-0.01903722435235977,
0.09055062383413315,
-0.09225541353225708,
-0.06264330446720123,
-0.05128723382949829,
-0.12075094878673553,
-0.12539364397525787,
0.09054937213659286,
-0.18850077688694,
-0.2850259840488434,
0.022317495197057724,
0.1474704146385193,
-0.23344936966896057,
0.3501751124858856,
0.03622275963425636,
-0.21364670991897583,
-0.01435062289237976,
0.14635272324085236,
-0.13097833096981049,
-0.09259703755378723,
0.025306835770606995,
-0.2325243204832077,
-0.19207961857318878,
-0.017154350876808167,
0.1055416613817215,
0.23248708248138428,
-0.05213456228375435,
0.14255261421203613,
0.011520064435899258,
0.009204378351569176,
0.1380390077829361,
-0.23539988696575165,
-0.0943034440279007,
-0.05120077356696129,
0.028291841968894005,
0.17673687636852264,
0.3839741349220276,
0.09072522819042206,
0.0990060344338417,
0.26952511072158813,
0.07459139823913574,
-0.056185945868492126,
0.01595153473317623,
-0.07001291960477829,
0.11922509223222733,
-0.11744371056556702,
0.04628055542707443,
-0.1285221427679062,
-0.08523458987474442,
0.12353625893592834,
0.20745138823986053,
-0.11059900373220444,
-0.10476958006620407,
0.10342545807361603,
0.03345026820898056,
0.3320256769657135,
0.29932573437690735,
-0.11686672270298004,
-0.3846210539340973,
-0.1683301031589508,
0.014180992729961872,
-0.40465083718299866,
0.1549464762210846,
0.2786817252635956,
0.0858142301440239,
0.006523401476442814,
-0.23583675920963287,
-0.14874610304832458,
-0.010860848240554333,
0.12802670896053314,
0.16390375792980194,
-0.20845171809196472,
0.046742502599954605,
0.05351157858967781,
-0.07829456776380539,
0.06971636414527893,
-0.08524343371391296,
0.11212947219610214,
-0.021032830700278282,
0.16922251880168915,
0.06380375474691391,
0.06297800689935684,
-0.08740217983722687,
-0.20413105189800262,
0.27793192863464355,
0.11792411655187607,
0.08142627030611038,
0.111129030585289,
-0.064287930727005,
0.006568301003426313,
-0.3311527967453003,
0.2070452868938446,
0.078355573117733,
-0.16087706387043,
0.08123660087585449,
-0.2524508535861969,
0.0037255750503391027,
0.21943022310733795,
0.08541456609964371,
0.029896894469857216,
-0.17523016035556793,
0.0882113054394722,
0.2878956198692322,
-0.15251056849956512,
-0.18309323489665985,
-0.17492471635341644,
-0.0627451092004776,
0.29293304681777954,
0.18183936178684235,
-0.13220010697841644,
-0.12231961637735367,
0.41351333260536194,
-0.06345062702894211,
0.10723482817411423,
-0.26585590839385986,
-0.186989426612854,
-0.20575518906116486,
-0.02786896377801895,
-0.20878535509109497,
-0.2668532133102417,
-0.2136325091123581,
-0.19590456783771515,
-0.26452940702438354,
-0.14642733335494995,
0.07351035624742508,
0.1731690764427185,
-0.05797261372208595,
-0.034992728382349014,
0.2086103856563568,
0.2587684690952301,
-0.0005580943543463945,
-0.005261353217065334,
-0.15680451691150665,
0.1005723625421524,
0.2642107605934143,
-0.05373723804950714,
0.2183455228805542,
-0.12338995188474655,
-0.07248656451702118,
-0.017423661425709724,
-0.009228004142642021,
0.018681446090340614,
0.24519270658493042,
-0.059912290424108505,
0.2079901397228241,
0.14595536887645721,
-0.006863695103675127,
0.12927566468715668,
-0.0599251426756382,
-0.3918113112449646,
0.054288964718580246,
0.10809910297393799,
0.2423064261674881,
-0.38160550594329834,
0.03287576138973236,
0.08492247760295868,
0.2964881956577301,
0.033905379474163055,
-0.11630336195230484,
0.031728584319353104,
0.23828688263893127,
-0.2554067075252533,
-0.11472249031066895,
-0.2810879349708557,
0.08424490690231323,
-0.04766697809100151,
0.2653665244579315,
0.20749914646148682,
0.1602509319782257,
-0.27309030294418335,
-0.1509363353252411,
0.16515307128429413,
0.31178390979766846,
-0.22115908563137054,
0.06983847916126251,
0.0644669309258461,
0.08497806638479233,
-0.16203418374061584,
-0.2825765013694763,
0.10258620232343674,
-0.2522105276584625,
0.15868164598941803,
-0.09517655521631241,
0.345016211271286,
-0.03382738307118416,
-0.24562576413154602,
-0.2505873441696167,
0.0027906461618840694,
-0.15546314418315887,
0.2720116674900055,
-0.3053410053253174,
0.46046894788742065,
-0.3300880789756775,
0.06192003935575485,
-0.06548777222633362,
-0.03411560878157616,
0.15370188653469086,
-0.03949622064828873,
-0.14731203019618988,
0.047796543687582016,
0.004998744465410709,
-0.062120623886585236,
0.005328414961695671,
-0.027926107868552208,
0.03550534322857857,
-0.30432525277137756,
-0.01370382122695446,
-0.1680920273065567,
0.0845545083284378,
-0.22234582901000977,
0.021360566839575768,
0.05162112042307854,
0.1843341886997223,
-0.1769028902053833,
-0.17809230089187622,
-0.13593930006027222,
0.32045823335647583,
0.3193606436252594,
-0.20457413792610168,
0.35645046830177307,
0.10592370480298996,
-0.20773643255233765,
-0.09501715004444122,
-0.29781922698020935,
-0.10032650083303452,
0.4459550678730011,
-0.09949570149183273,
-0.17556805908679962,
-0.010104275308549404,
-0.23619815707206726,
0.1636364907026291,
0.14920182526111603,
0.22474613785743713,
-0.01651730202138424,
0.25359171628952026,
-0.028243323788046837,
0.11486857384443283,
-0.16967570781707764,
0.05897661671042442,
0.002226118929684162,
-0.04330528527498245,
-0.07852613180875778,
0.39527589082717896,
-0.04484720900654793,
0.07433617860078812,
-0.0643833577632904,
0.08314455300569534,
0.057536158710718155,
-0.23932185769081116,
0.148840069770813,
-0.04827363044023514,
0.07236077636480331,
-0.07114274054765701,
-0.11955424398183823,
-0.26756319403648376,
-0.29681268334388733,
-0.030474578961730003,
0.0523207001388073,
-0.10010408610105515,
0.28300940990448,
0.024287395179271698,
0.3070133924484253,
-0.02585424855351448,
-0.23942051827907562,
-0.1271311193704605,
0.0926663726568222,
-0.06999000161886215,
-0.022849854081869125,
-0.023954730480909348,
-0.09482438117265701,
-0.10651884227991104,
0.2563449740409851,
-0.15881380438804626,
0.164552241563797,
0.03938362002372742,
-0.010376575402915478,
-0.22230836749076843,
-0.24511384963989258,
-0.023594800382852554,
-0.03758822754025459,
-0.12878131866455078,
-0.09592680633068085,
-0.12522120773792267,
-0.0975697785615921,
-0.014071259647607803,
0.023708710446953773,
0.06313670426607132,
0.20553457736968994,
-0.023480890318751335,
0.16537050902843475,
0.1335638165473938,
0.3018413484096527,
-0.09997642040252686,
-0.07436865568161011,
-0.20880961418151855,
-0.15096502006053925,
-0.08228708803653717,
0.10698489844799042,
0.05379023402929306,
0.13053645193576813,
0.08700878918170929,
0.29591313004493713,
0.05202065408229828,
-0.24072450399398804,
0.05634666606783867,
-0.0599086619913578,
-0.1644376963376999,
-0.1356821358203888,
0.04978097975254059,
-0.2637925148010254,
0.03845030441880226,
0.07646314054727554,
-0.06100161001086235,
-0.05762101709842682
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. as "iminodipeptiduria." Iminodipeptides are dipeptides in which proline or hydroxyproline is the N-terminal amino acid (i.e., Pro/Hyp-X, for example prolylglycine), whereas imidodipeptides are dipeptides in which proline or hydroxyproline is the C-terminal amino acid (i.e., X-Pro/Hyp, for example glycylproline).Establishing the DiagnosisThe diagnosis of prolidase deficiency is established in a proband (who has the characteristic clinical findings and imidodipeptiduria) by detection of either biallelic PEPD pathogenic variants (see Table 2) or reduced prolidase enzyme activity.Molecular genetic testing approaches include single gene testing and targeted analysis for pathogenic variants.Single-gene testing. For most individuals, sequence analysis of PEPD is performed first, followed by gene-targeted deletion/duplication analysis if only one or no pathogenic variant is found | [
-0.08557837456464767,
0.18236924707889557,
-0.2446661740541458,
-0.16352130472660065,
0.16745060682296753,
0.12742573022842407,
-0.03391420468688011,
0.021540842950344086,
0.2583288252353668,
-0.13543403148651123,
0.2171594798564911,
0.2905747592449188,
0.17811933159828186,
-0.05616338178515434,
-0.22375135123729706,
-0.001443313667550683,
0.3465537428855896,
-0.09295347332954407,
0.009914746508002281,
-0.015887733548879623,
0.2111620008945465,
-0.030923865735530853,
0.22791865468025208,
0.1932629942893982,
0.2920546531677246,
0.11755000799894333,
-0.07229901105165482,
0.11701813340187073,
0.08340740948915482,
-0.17223882675170898,
-0.1144580990076065,
0.012020896188914776,
0.026026416569948196,
-0.30807650089263916,
0.2558627724647522,
-0.1961268186569214,
-0.2538994252681732,
0.1098463162779808,
0.14029276371002197,
0.06102081015706062,
-0.040031492710113525,
-0.1027318686246872,
0.13632753491401672,
0.07321043312549591,
0.05885296314954758,
-0.018429793417453766,
-0.015398736111819744,
0.1109699010848999,
-0.11012499034404755,
0.08651412278413773,
0.21738088130950928,
-0.09619774669408798,
-0.10134232044219971,
-0.027431054040789604,
0.3028424382209778,
0.1698746532201767,
0.19167059659957886,
0.010022750124335289,
0.06243976578116417,
0.003701037960126996,
0.05904041975736618,
-0.04800328239798546,
-0.07561523467302322,
-0.3569425046443939,
0.08629795163869858,
-0.10764927417039871,
0.28663697838783264,
-0.023327771574258804,
-0.13791461288928986,
0.028621496632695198,
0.40189412236213684,
-0.30759525299072266,
0.2974977493286133,
0.18803012371063232,
-0.21941497921943665,
-0.24359333515167236,
0.10545936226844788,
-0.05446385592222214,
0.10781301558017731,
-0.2777157425880432,
-0.25505736470222473,
0.30036410689353943,
0.05588649585843086,
0.11183130741119385,
-0.2504405379295349,
0.289838582277298,
0.16220992803573608,
0.055396080017089844,
-0.02015353925526142,
0.09741809219121933,
0.14567866921424866,
-0.12637968361377716,
0.06102810427546501,
-0.038601212203502655,
0.07410617172718048,
-0.1980513632297516,
0.11327558010816574,
0.028012920171022415,
-0.2535876929759979,
0.27917495369911194,
-0.05651058256626129,
0.21237826347351074,
-0.20531238615512848,
-0.06991472840309143,
0.1358010619878769,
-0.0635293573141098,
-0.21007481217384338,
-0.21480734646320343,
-0.017262103036046028,
-0.11264084279537201,
0.0780067965388298,
0.06829527765512466,
-0.20896250009536743,
-0.14602747559547424,
-0.32515498995780945,
-0.0018283327808603644,
0.38042575120925903,
-0.1517753303050995,
-0.10336826741695404,
-0.0458662323653698,
-0.0003239459765609354,
0.20187914371490479,
-0.07834228873252869,
-0.0655684769153595,
0.42133867740631104,
0.1797482818365097,
0.24969780445098877,
0.10491510480642319,
0.38331741094589233,
-0.08760042488574982,
0.00457068532705307,
0.10368581116199493,
0.15551406145095825,
-0.07781466841697693,
0.05294503644108772,
0.07979878038167953,
-0.17811201512813568,
-0.0758574903011322,
-0.06760719418525696,
0.07326751947402954,
0.01605905592441559,
-0.09520405530929565,
0.1673448234796524,
0.23852312564849854,
-0.013689848594367504,
0.16476626694202423,
0.25582146644592285,
-0.24262110888957977,
0.24042297899723053,
0.07296910136938095,
0.1759461909532547,
-0.04596488177776337,
0.10099031776189804,
-0.019965549930930138,
0.17129069566726685,
0.11094360053539276,
-0.29255276918411255,
0.12625519931316376,
-0.11625514179468155,
0.08082731813192368,
0.0953148826956749,
-0.13622376322746277,
0.16780366003513336,
-0.2688228189945221,
0.21566879749298096,
-0.17623387277126312,
-0.19040948152542114,
0.015078200958669186,
0.14937961101531982,
0.13726745545864105,
-0.15063129365444183,
0.07115412503480911,
0.06527353823184967,
0.07668989151716232,
0.29659780859947205,
-0.04782138764858246,
0.06143226474523544,
0.09708337485790253,
-0.07726352661848068,
0.08060427755117416,
0.06656821072101593,
0.1113453060388565,
-0.14398588240146637,
0.17930713295936584,
-0.07889954745769501,
-0.023609790951013565,
-0.1454160362482071,
0.32222306728363037,
0.15744811296463013,
0.3328845202922821,
0.20903438329696655,
0.21797049045562744,
-0.0034220991656184196,
-0.11116720736026764,
0.12888965010643005,
-0.2374870777130127,
0.2641955614089966,
-0.048894546926021576,
0.1060432568192482,
-0.16174018383026123,
0.40723782777786255,
-0.18815970420837402,
0.10234423726797104,
-0.17389672994613647,
0.24133789539337158,
0.05372108519077301,
0.1266089379787445,
-0.04632158949971199,
-0.04179046303033829,
0.4268825352191925,
0.06196637824177742,
0.08547340333461761,
-0.10438060760498047,
0.3164100646972656,
-0.08010092377662659,
-0.008726865984499454,
-0.2360079288482666,
0.02040955051779747,
-0.1087917685508728,
-0.10851158946752548,
-0.12706206738948822,
-0.16773606836795807,
-0.07820921391248703,
-0.0952485129237175,
0.13160832226276398,
-0.0695924162864685,
0.027249693870544434,
-0.018448099493980408,
0.11652076989412308,
-0.06079811602830887,
-0.21764831244945526,
-0.005811333656311035,
0.3643258213996887,
0.22979626059532166,
-0.17459756135940552,
-0.1526292860507965,
-0.14068959653377533,
0.07415087521076202,
-0.16000474989414215,
-0.115183524787426,
-0.3289722502231598,
0.07724402099847794,
-0.023481272161006927,
0.0008086104644462466,
-0.08844105899333954,
-0.06889265030622482,
-0.07168333232402802,
0.07819119095802307,
0.05313623324036598,
0.2143680453300476,
-0.05167165398597717,
0.0334896482527256,
0.053017646074295044,
-0.02282480150461197,
-0.4559951424598694,
0.06815867125988007,
-0.03259601071476936,
-0.17444805800914764,
0.08103564381599426,
0.09566250443458557,
-0.1786540150642395,
-0.014841027557849884,
0.02319910004734993,
0.07648687809705734,
-0.059788089245557785,
-0.02823280356824398,
-0.1921073943376541,
-0.04364124312996864,
0.1105336919426918,
-0.29829221963882446,
0.041954148560762405,
-0.11158701777458191,
0.2958405911922455,
0.14703011512756348,
-0.06313786655664444,
-0.01720106042921543,
-0.036214277148246765,
0.08258378505706787,
-0.04363204166293144,
-0.4064704179763794,
-0.12446785718202591,
0.23131287097930908,
-0.19895994663238525,
-0.3112098276615143,
0.11209242045879364,
0.09049102663993835,
-0.15360377728939056,
0.3065505623817444,
-0.1475910097360611,
-0.01508182380348444,
0.1075574979186058,
0.13122816383838654,
-0.07079833000898361,
-0.20866228640079498,
-0.1335906833410263,
-0.1369537115097046,
-0.09813205152750015,
0.024170899763703346,
0.07825906574726105,
-0.13201028108596802,
0.3185807764530182,
0.14520613849163055,
0.10548337548971176,
0.06716497242450714,
-0.2849256694316864,
-0.18192198872566223,
-0.07242229580879211,
0.10219405591487885,
-0.19695402681827545,
-0.023877371102571487,
-0.0786128044128418,
-0.041724950075149536,
-0.18785282969474792,
-0.07368555665016174,
0.2564132511615753,
-0.0805869922041893,
-0.2601090371608734,
0.026551244780421257,
-0.09146670252084732,
0.15306417644023895,
0.31469374895095825,
-0.22738802433013916,
0.06521894037723541,
0.2135385274887085,
-0.09093869477510452,
-0.0069018821232020855,
-0.06908057630062103,
-0.11485800892114639,
0.14251384139060974,
-0.09871059656143188,
-0.004985835403203964,
0.13668818771839142,
0.03472524508833885,
-0.11816294491291046,
0.10974050313234329,
-0.1548651158809662,
0.4736563265323639,
0.07834304869174957,
0.028202228248119354,
-0.10240312665700912,
0.04625917971134186,
-0.48250812292099,
0.07325795292854309,
-0.10819748789072037,
-0.05581370368599892,
-0.008157121948897839,
0.1668064296245575,
0.1706288903951645,
0.44094836711883545,
-0.192312553524971,
-0.27868905663490295,
0.012404120527207851,
0.018898531794548035,
-0.08696382492780685,
0.09842714667320251,
0.025798296555876732,
-0.15502676367759705,
0.14763589203357697,
0.2932901978492737,
-0.044636718928813934,
-0.1431935876607895,
-0.011911463923752308,
0.058462467044591904,
-0.07794217020273209,
0.06104033812880516,
0.294346421957016,
0.0014395060716196895,
0.0754573792219162,
0.18999336659908295,
0.18252190947532654,
0.04918632656335831,
0.11088719964027405,
0.1786426305770874,
0.1709415167570114,
-0.04417184740304947,
0.12765876948833466,
-0.3619152009487152,
0.03271425887942314,
0.18629635870456696,
0.024919765070080757,
-0.05722739174962044,
0.060175295919179916,
0.1243426501750946,
0.2127540111541748,
-0.10627352446317673,
0.22501373291015625,
-0.16672101616859436,
0.2096763253211975,
-0.06119759380817413,
-0.09625131636857986,
0.18729114532470703,
0.1116422787308693,
-0.09445612132549286,
0.09256390482187271,
-0.33906054496765137,
0.2252368927001953,
-0.067575603723526,
-0.153813898563385,
-0.2830859422683716,
0.22271104156970978,
0.010987205430865288,
0.05457678064703941,
0.26114094257354736,
0.04281233996152878,
0.09751709550619125,
0.2679774761199951,
0.0795249491930008,
0.147321879863739,
0.23688918352127075,
0.02067228965461254,
0.10895845293998718,
0.07243078947067261,
0.02856244519352913,
-0.11186909675598145,
0.007469152100384235,
-0.04579829424619675,
-0.13975900411605835,
0.37794291973114014,
0.270521879196167,
0.04867103695869446,
-0.3342907428741455,
0.04746681824326515,
0.1517375260591507,
0.008894792757928371,
-0.1497175395488739,
-0.1605660617351532,
0.028657592833042145,
-0.11732956767082214,
0.12206492573022842,
0.30082741379737854,
0.11750194430351257,
0.12090229988098145,
-0.0753059834241867,
0.007043474819511175,
0.18808048963546753,
-0.1195918619632721,
-0.03235970064997673,
0.043572165071964264,
0.1556158810853958,
-0.00881616398692131,
0.4365375339984894,
-0.21877890825271606,
-0.3981303870677948,
-0.15404818952083588,
-0.1116955429315567,
0.04418513923883438,
-0.04439796134829521,
-0.053462281823158264,
0.12309891730546951,
0.09726593643426895,
0.17372176051139832,
0.006625803653150797,
0.25260892510414124,
0.12556608021259308,
0.03406911343336105,
0.14466910064220428,
-0.03224857151508331,
-0.06904302537441254,
-0.14609339833259583,
-0.09983181208372116,
-0.08583780378103256,
0.050269488245248795,
-0.13546213507652283,
-0.2911785840988159,
0.05776029825210571,
0.15347576141357422,
-0.25312432646751404,
0.3164498209953308,
0.09929396212100983,
-0.1520766168832779,
0.0024620776530355215,
0.2072717845439911,
-0.004084215499460697,
-0.05186395347118378,
-0.04467886686325073,
-0.1448943316936493,
-0.15180309116840363,
-0.05785014480352402,
0.07049758732318878,
0.26573091745376587,
0.005296907853335142,
0.0344817228615284,
-0.1106172427535057,
0.04239204153418541,
0.1431874930858612,
-0.23716287314891815,
0.004112460184842348,
-0.12584441900253296,
0.035178810358047485,
0.14114363491535187,
0.3464832603931427,
0.12081598490476608,
0.030003156512975693,
0.3239936828613281,
0.03465982899069786,
0.00018755163182504475,
-0.0430431067943573,
-0.0985584557056427,
0.05198248103260994,
-0.1360710710287094,
0.06254302710294724,
-0.07843950390815735,
-0.10047149658203125,
0.15663519501686096,
0.24978671967983246,
-0.14527729153633118,
-0.08892957121133804,
-0.003609737614169717,
0.139449805021286,
0.372341126203537,
0.1937381774187088,
-0.15904758870601654,
-0.3083603084087372,
-0.08001548796892166,
-0.011424153111875057,
-0.47142982482910156,
0.041861142963171005,
0.16713032126426697,
0.13655324280261993,
0.0998455286026001,
-0.18332962691783905,
-0.1626364290714264,
0.013133787550032139,
0.11969000101089478,
0.10750973969697952,
-0.17382997274398804,
0.028627293184399605,
0.012238141149282455,
-0.07231255620718002,
-0.054200973361730576,
-0.14463655650615692,
0.11087656766176224,
0.002061442006379366,
0.10348590463399887,
0.0890689566731453,
0.011325214058160782,
-0.03061482310295105,
-0.2655222415924072,
0.27899521589279175,
0.08725760877132416,
-0.02231874316930771,
0.018680894747376442,
-0.002739065093919635,
0.029155023396015167,
-0.3600725829601288,
0.21560950577259064,
0.0934215784072876,
-0.06683892756700516,
0.021217554807662964,
-0.155857115983963,
0.0466318316757679,
0.08917708694934845,
-0.017896048724651337,
0.06816533952951431,
-0.23240531980991364,
0.03595111891627312,
0.1929946392774582,
-0.09761004894971848,
-0.17090758681297302,
-0.17535176873207092,
-0.1768689900636673,
0.2658531963825226,
0.0820799395442009,
-0.0960376113653183,
-0.21132232248783112,
0.4122735857963562,
-0.10751987993717194,
0.10665574669837952,
-0.25916358828544617,
-0.16024249792099,
-0.21805909276008606,
-0.0034551199059933424,
-0.11324448138475418,
-0.2888006269931793,
-0.17070449888706207,
-0.16310271620750427,
-0.17576053738594055,
-0.26576751470565796,
0.10063789784908295,
0.14177541434764862,
-0.01585298776626587,
-0.01232211198657751,
0.20875361561775208,
0.26581910252571106,
0.014741629362106323,
-0.01262853667140007,
-0.08563024550676346,
0.1612536907196045,
0.17622655630111694,
-0.0953223705291748,
0.17847520112991333,
-0.19802092015743256,
-0.11995092779397964,
-0.07552675157785416,
-0.03649716079235077,
0.02991805411875248,
0.1553831696510315,
-0.08024567365646362,
0.11299053579568863,
0.03377286344766617,
-0.016209444031119347,
0.06546055525541306,
-0.09477122873067856,
-0.4644753634929657,
-0.004627428017556667,
0.13502025604248047,
0.2647964060306549,
-0.46750396490097046,
0.07382120192050934,
0.10427666455507278,
0.30019819736480713,
0.059951696544885635,
-0.042762044817209244,
0.07411404699087143,
0.26847192645072937,
-0.2169055938720703,
-0.005372428335249424,
-0.2579239308834076,
0.09623056650161743,
-0.08567775785923004,
0.23219850659370422,
0.21994838118553162,
0.18316011130809784,
-0.21556076407432556,
-0.1478150337934494,
0.1506795883178711,
0.21473930776119232,
-0.1311149001121521,
0.02303624339401722,
0.045963529497385025,
0.07608404010534286,
-0.111373670399189,
-0.26257243752479553,
0.16096137464046478,
-0.20101763308048248,
0.21924977004528046,
-0.0884564220905304,
0.1946226954460144,
-0.05912570655345917,
-0.19473105669021606,
-0.2747451961040497,
0.14586591720581055,
-0.1580951064825058,
0.3643932342529297,
-0.21907342970371246,
0.4134838879108429,
-0.2614618241786957,
-0.00761908944696188,
-0.11226023733615875,
0.058374397456645966,
0.21274259686470032,
-0.03019343875348568,
-0.21039535105228424,
0.1516374945640564,
0.05892599746584892,
-0.07541630417108536,
0.07240749150514603,
-0.07779762893915176,
0.10654091835021973,
-0.3447299897670746,
0.015948904678225517,
-0.1153225526213646,
-0.010969450697302818,
-0.17902342975139618,
0.05681542307138443,
-0.04344368353486061,
0.24069219827651978,
-0.15636219084262848,
-0.16925427317619324,
-0.19459044933319092,
0.326244980096817,
0.4148150384426117,
-0.18755896389484406,
0.2825988531112671,
0.1304708570241928,
-0.19861650466918945,
-0.13606324791908264,
-0.21692858636379242,
-0.12238384783267975,
0.37250232696533203,
-0.07740439474582672,
-0.2276899367570877,
-0.05992656946182251,
-0.2082550972700119,
0.16949671506881714,
0.0990954264998436,
0.11725267767906189,
0.027863018214702606,
0.32410746812820435,
-0.07167530804872513,
0.10462744534015656,
-0.2373506724834442,
0.03452110290527344,
0.005296262446790934,
-0.09352278709411621,
-0.04198349267244339,
0.32821154594421387,
-0.025541264563798904,
0.1500057727098465,
-0.0876944288611412,
0.041320692747831345,
-0.013091817498207092,
-0.17140698432922363,
0.12700772285461426,
-0.043911051005125046,
0.10383151471614838,
-0.039937663823366165,
-0.07672003656625748,
-0.34735962748527527,
-0.22215507924556732,
-0.048871979117393494,
0.034779079258441925,
-0.10329670459032059,
0.2546444237232208,
0.00874084047973156,
0.2364291250705719,
0.023006964474916458,
-0.32296043634414673,
-0.1718878149986267,
0.12656089663505554,
-0.05164870247244835,
0.07493580132722855,
-0.046781957149505615,
-0.10635361075401306,
-0.04977086931467056,
0.2703704833984375,
-0.23179568350315094,
0.1697961539030075,
0.08726660162210464,
-0.02263844758272171,
-0.22336895763874054,
-0.25846102833747864,
-0.13482914865016937,
-0.015335222706198692,
-0.1161695346236229,
-0.07396582514047623,
-0.093021459877491,
-0.12962093949317932,
-0.03153318911790848,
0.04917827621102333,
0.0657874196767807,
0.183489590883255,
-0.03615320846438408,
0.09336936473846436,
0.18229065835475922,
0.2969639003276825,
-0.11029469221830368,
-0.14040902256965637,
-0.11357779055833817,
-0.13608257472515106,
-0.12841622531414032,
0.05515538901090622,
-0.0437481664121151,
0.12734481692314148,
0.018746955320239067,
0.23501509428024292,
0.042604196816682816,
-0.2729012072086334,
0.040400467813014984,
0.006248319987207651,
-0.1272350698709488,
-0.14948958158493042,
0.12333260476589203,
-0.3493320047855377,
0.00604271749034524,
-0.014541730284690857,
-0.03780994564294815,
0.019729340448975563
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. The diagnosis of prolidase deficiency is established in a proband (who has the characteristic clinical findings and imidodipeptiduria) by detection of either biallelic PEPD pathogenic variants (see Table 2) or reduced prolidase enzyme activity.Molecular genetic testing approaches include single gene testing and targeted analysis for pathogenic variants.Single-gene testing. For most individuals, sequence analysis of PEPD is performed first, followed by gene-targeted deletion/duplication analysis if only one or no pathogenic variant is found.Targeted analysis for pathogenic variants. For Amish from Geauga County, Ohio and Druze and Arab Muslims from northern Israel, testing for the founder variants p.Arg265Ter and p.Ser202Phe, respectively, may be performed first followed by sequence analysis and gene-targeted deletion/duplication analysis if one or no pathogenic variant is identified.Table 2. Summary of Molecular Genetic Testing Used in Prolidase DeficiencyView in own window | [
-0.032126396894454956,
0.15235406160354614,
0.04830462858080864,
-0.2119455486536026,
0.12121514976024628,
0.1796141415834427,
-0.00021551665849983692,
-0.09095010161399841,
0.05821232870221138,
-0.057724740356206894,
0.017038270831108093,
0.15319067239761353,
0.20629286766052246,
-0.05729132518172264,
-0.17417237162590027,
0.138177290558815,
0.18120183050632477,
0.049629535526037216,
0.01245657354593277,
0.019660037010908127,
0.010852500796318054,
-0.08813156932592392,
0.4015703797340393,
0.17002803087234497,
0.21891921758651733,
-0.11690735071897507,
0.05622965097427368,
-0.02457316406071186,
-0.00571935810148716,
0.004780173301696777,
0.036600511521101,
-0.11757943779230118,
-0.06502596288919449,
-0.2713439166545868,
0.048650629818439484,
-0.14048857986927032,
-0.032475464046001434,
-0.02929787151515484,
0.19348041713237762,
-0.0979589894413948,
-0.06597072631120682,
-0.002461941447108984,
0.19959187507629395,
0.11856134980916977,
0.022654272615909576,
-0.09132064133882523,
0.09477763622999191,
0.08869678527116776,
-0.08315468579530716,
0.04450417682528496,
0.1325925886631012,
-0.044976606965065,
-0.08006521314382553,
-0.16286760568618774,
0.2947218120098114,
0.21596059203147888,
0.014012440107762814,
-0.029440579935908318,
-0.13204045593738556,
-0.029818179085850716,
0.0862194150686264,
0.03234340250492096,
-0.24104158580303192,
-0.3312426209449768,
0.3192557394504547,
-0.11691024899482727,
0.24201098084449768,
-0.22060099244117737,
-0.14841625094413757,
-0.06464117765426636,
0.33475929498672485,
-0.02187945879995823,
0.35210543870925903,
0.03822454437613487,
-0.18859872221946716,
0.008818145841360092,
0.12657082080841064,
0.07209877669811249,
-0.011639628559350967,
-0.2995440661907196,
-0.1941872388124466,
0.07477355003356934,
-0.0503835491836071,
0.12848436832427979,
-0.015156722627580166,
0.14499279856681824,
0.12722742557525635,
0.03752599656581879,
0.09638414531946182,
-0.005352646578103304,
0.15962068736553192,
-0.11112075299024582,
0.15313710272312164,
-0.0882432758808136,
-0.009541201405227184,
-0.1368531733751297,
-0.005466786678880453,
-0.009958574548363686,
-0.10171133279800415,
0.18799664080142975,
0.09667298942804337,
0.13323478400707245,
0.020615102723240852,
0.01094356644898653,
0.24162980914115906,
-0.08399064838886261,
-0.15740779042243958,
-0.04556018486618996,
-0.07531298696994781,
-0.10088860243558884,
0.08883147686719894,
0.085370734333992,
-0.1217864528298378,
0.00017648444918449968,
-0.08882470428943634,
0.04355022311210632,
0.2757100462913513,
0.0024717815686017275,
-0.06101985648274422,
-0.1708400398492813,
0.016246462240815163,
0.022100139409303665,
0.06144622713327408,
-0.14542192220687866,
0.21741780638694763,
0.03186929225921631,
0.24202227592468262,
0.10795743763446808,
0.26462215185165405,
-0.0832616537809372,
0.03334027901291847,
0.05865554139018059,
-0.009459162130951881,
-0.04819183051586151,
-0.14304706454277039,
-0.09814063459634781,
-0.219893217086792,
-0.09438730776309967,
-0.044392649084329605,
-0.009476582519710064,
0.0893319696187973,
0.05287874862551689,
0.21645791828632355,
0.24488666653633118,
-0.05682266876101494,
0.1916162371635437,
0.21365763247013092,
-0.193582221865654,
0.032092366367578506,
-0.02871047705411911,
0.09420432895421982,
-0.029088526964187622,
0.4167602062225342,
-0.06698860228061676,
0.043651945888996124,
0.004782157484441996,
-0.1832747608423233,
0.1706058233976364,
-0.17030929028987885,
0.13765275478363037,
0.24881881475448608,
-0.11982966214418411,
0.11265918612480164,
-0.14175333082675934,
0.17023248970508575,
-0.04571997746825218,
-0.05016734078526497,
0.16042032837867737,
0.12683747708797455,
0.1404963731765747,
-0.07773637026548386,
0.05751830339431763,
0.02549206279218197,
0.06247919797897339,
0.2490403950214386,
-0.07383400201797485,
-0.06160163879394531,
0.0244803074747324,
0.007139917928725481,
-0.00510761933401227,
-0.0350467748939991,
-0.04115544259548187,
-0.1331113874912262,
-0.003052367130294442,
-0.16148483753204346,
-0.02510366402566433,
0.005509519949555397,
0.1983799934387207,
0.14230617880821228,
0.26625317335128784,
0.16388937830924988,
0.11999550461769104,
-0.018043627962470055,
-0.062196195125579834,
0.2482525259256363,
-0.12542776763439178,
0.11100506037473679,
0.07581979781389236,
-0.1093672662973404,
-0.16926605999469757,
0.20459899306297302,
-0.1637260764837265,
0.0599103681743145,
-0.0038462646771222353,
-0.05079188197851181,
0.08534714579582214,
0.09271923452615738,
0.09779813885688782,
-0.046558454632759094,
0.2885999381542206,
0.02257072553038597,
0.08650032430887222,
-0.13006655871868134,
0.31888076663017273,
-0.03752797096967697,
-0.06534688919782639,
-0.17442893981933594,
-0.05237028747797012,
-0.036473434418439865,
0.07791170477867126,
-0.07417802512645721,
-0.0837063118815422,
-0.09529420733451843,
-0.15272442996501923,
0.09413908421993256,
0.07607180625200272,
-0.1282927393913269,
0.13115806877613068,
0.008423477411270142,
-0.12116434425115585,
-0.11935506761074066,
-0.024965548887848854,
0.17419245839118958,
0.261791855096817,
-0.16607972979545593,
-0.12152762711048126,
0.03205477446317673,
0.17604832351207733,
0.2038842886686325,
-0.04278276115655899,
-0.26500841975212097,
-0.018523573875427246,
0.09546182304620743,
0.05105601251125336,
-0.06516467034816742,
-0.018383195623755455,
-0.0567912720143795,
0.09169434010982513,
-0.05505060777068138,
0.09488143771886826,
-0.08189752697944641,
0.02061440795660019,
0.11918525397777557,
-0.054595980793237686,
-0.5138767957687378,
0.059983689337968826,
-0.08210193365812302,
-0.13433599472045898,
0.05869736149907112,
0.01344323344528675,
-0.012201874516904354,
0.00011864498810609803,
0.11008960008621216,
0.09547127038240433,
0.11873932182788849,
-0.000023962131308508106,
-0.2511642575263977,
0.020740656182169914,
-0.09631885588169098,
-0.3501136004924774,
-0.07074486464262009,
0.052426569163799286,
0.2057773619890213,
0.16593456268310547,
-0.05347627028822899,
-0.007854437455534935,
-0.0831843838095665,
0.042506102472543716,
0.019261782988905907,
-0.19752036035060883,
-0.11700330674648285,
0.11976339668035507,
-0.15165135264396667,
-0.06580575555562973,
0.12345245480537415,
0.06878190487623215,
0.07950463891029358,
0.15235549211502075,
-0.1310463845729828,
0.08746201545000076,
0.15508858859539032,
0.08712582290172577,
-0.17914427816867828,
-0.04955508932471275,
-0.01642308570444584,
0.059293363243341446,
0.01706339791417122,
-0.02710420824587345,
0.06029325723648071,
0.0014909624587744474,
0.18493765592575073,
-0.05792023614048958,
0.026555733755230904,
-0.07341738045215607,
-0.2318994700908661,
-0.05715940520167351,
0.030323466286063194,
0.10476270318031311,
-0.19794656336307526,
0.1995670199394226,
-0.16661027073860168,
-0.0173308327794075,
-0.2760191857814789,
-0.1539166271686554,
0.10925012081861496,
0.023841461166739464,
-0.32874464988708496,
0.1900903582572937,
-0.00836812611669302,
0.22756385803222656,
0.2784421145915985,
-0.1028050109744072,
0.13970036804676056,
0.1305193305015564,
-0.07743489742279053,
-0.07338220626115799,
-0.13307411968708038,
-0.030570095404982567,
0.0775599479675293,
-0.10433273762464523,
-0.019639302045106888,
0.14924724400043488,
0.025582442060112953,
-0.14666970074176788,
0.0754895806312561,
0.07088832557201385,
0.2524784803390503,
-0.18467848002910614,
-0.10461065173149109,
0.044214118272066116,
0.0895371362566948,
-0.18137162923812866,
-0.10533017665147781,
-0.06441859155893326,
-0.06422552466392517,
-0.03335445746779442,
0.04506455734372139,
-0.030504433438181877,
0.1596265435218811,
-0.13885273039340973,
-0.055120598524808884,
0.011086143553256989,
0.016626831144094467,
-0.21745114028453827,
0.23558785021305084,
0.2716459333896637,
-0.010680942796170712,
0.013753687962889671,
0.16312290728092194,
-0.06940237432718277,
-0.04117203503847122,
0.16422487795352936,
0.26375654339790344,
-0.14278513193130493,
0.09635493159294128,
0.10449729859828949,
0.15793314576148987,
0.155910462141037,
0.07344740629196167,
0.15483662486076355,
-0.005989603698253632,
0.023076718673110008,
0.11071331053972244,
0.17903321981430054,
0.008851170539855957,
0.11946075409650803,
-0.11066964268684387,
0.11559900641441345,
0.014500427059829235,
-0.15250667929649353,
0.008502953685820103,
-0.0385168120265007,
0.11165177077054977,
0.18514011800289154,
-0.01035168208181858,
0.33645811676979065,
-0.1817924678325653,
0.04426328465342522,
0.028795521706342697,
-0.08259575814008713,
0.05224671587347984,
0.22546091675758362,
0.015771090984344482,
-0.08699272572994232,
-0.26736578345298767,
0.07834078371524811,
-0.11368441581726074,
-0.11319927871227264,
-0.1576767861843109,
0.05844953656196594,
0.012950681149959564,
-0.13447998464107513,
0.08636929839849472,
0.06442670524120331,
-0.023959793150424957,
0.09025552123785019,
0.09351177513599396,
0.15280741453170776,
0.1966458410024643,
-0.026995686814188957,
0.16844403743743896,
0.1017363891005516,
-0.050501108169555664,
-0.02310534194111824,
-0.052217092365026474,
-0.06922826170921326,
-0.06099271401762962,
0.11792591959238052,
0.11450830847024918,
0.09902096539735794,
-0.24805621802806854,
0.06449020653963089,
0.24227556586265564,
-0.02573126181960106,
0.01120644249022007,
-0.13723932206630707,
-0.020555581897497177,
-0.10757225006818771,
0.1706075817346573,
0.10384521633386612,
0.17205774784088135,
0.16339416801929474,
-0.15050078928470612,
0.060383379459381104,
0.1134713888168335,
-0.02219627983868122,
0.22261455655097961,
0.04697851836681366,
0.18523891270160675,
0.09969166666269302,
0.1487029641866684,
0.03732568398118019,
-0.22362932562828064,
-0.10122118145227432,
-0.10437333583831787,
0.15026363730430603,
-0.005766511894762516,
0.13545601069927216,
0.09919580817222595,
0.08494000881910324,
0.015082769095897675,
-0.15010344982147217,
0.00896566454321146,
-0.10811164975166321,
-0.09275922179222107,
0.12946252524852753,
-0.13226179778575897,
-0.1410088837146759,
-0.051249049603939056,
-0.1363043189048767,
0.0381031297147274,
0.24328747391700745,
-0.03594018518924713,
-0.10405761003494263,
0.09750863909721375,
0.07964633405208588,
-0.08548780530691147,
0.032456811517477036,
0.1736217886209488,
-0.06302782148122787,
0.23259544372558594,
0.1255834847688675,
-0.010090704075992107,
-0.06004073843359947,
-0.11227624863386154,
0.09698738902807236,
0.06977692991495132,
-0.02773570455610752,
-0.052916042506694794,
0.09466460347175598,
-0.06255373358726501,
-0.012112152762711048,
-0.24243049323558807,
0.0304894857108593,
-0.019052712246775627,
0.03753705695271492,
0.16652777791023254,
-0.11726460605859756,
-0.08817866444587708,
-0.03890419378876686,
0.07162065804004669,
0.12518170475959778,
-0.07586298882961273,
0.2183699607849121,
-0.020999690517783165,
-0.17588302493095398,
-0.06613016128540039,
-0.14556068181991577,
-0.0638032853603363,
-0.13606730103492737,
-0.03713684529066086,
0.047368500381708145,
0.0617792010307312,
0.28246447443962097,
0.15435588359832764,
-0.21489086747169495,
0.0013011657865718007,
-0.15358375012874603,
0.1112559363245964,
0.2899989187717438,
0.06278304755687714,
-0.13211509585380554,
-0.17006731033325195,
0.0493677482008934,
-0.18706336617469788,
-0.21516239643096924,
0.08749008923768997,
0.02270456776022911,
0.20354342460632324,
0.026532532647252083,
0.09002860635519028,
-0.12271615117788315,
0.03365854546427727,
0.11892352998256683,
0.06822007149457932,
-0.33998146653175354,
0.018709946423768997,
0.13942953944206238,
-0.13964641094207764,
-0.24928425252437592,
-0.18719780445098877,
0.056194715201854706,
-0.12027660757303238,
0.08383497595787048,
-0.06854535639286041,
0.059581875801086426,
-0.07325856387615204,
-0.207219660282135,
-0.034998491406440735,
-0.06273629516363144,
-0.0548083521425724,
0.04534607008099556,
0.08417922258377075,
-0.013751565478742123,
-0.07407541573047638,
0.15024317800998688,
0.05920468270778656,
-0.07431867718696594,
0.0714505985379219,
-0.03485499322414398,
-0.09072671830654144,
0.04498520493507385,
0.023230889812111855,
0.03298656642436981,
-0.14125218987464905,
-0.06648173928260803,
0.032305050641298294,
-0.10092362016439438,
-0.1784602254629135,
-0.014481631107628345,
-0.05072670057415962,
-0.009167518466711044,
-0.12919172644615173,
-0.17004334926605225,
-0.10786973685026169,
0.33262157440185547,
-0.061251912266016006,
-0.022471126168966293,
0.029134193435311317,
-0.02044401690363884,
-0.183753103017807,
0.0742991492152214,
0.1470569372177124,
-0.12802422046661377,
-0.2078678458929062,
-0.060649752616882324,
-0.07081927359104156,
-0.151096373796463,
-0.08347553014755249,
0.16282491385936737,
-0.04941286891698837,
-0.18342889845371246,
-0.0013853750424459577,
0.11785740405321121,
0.08962427824735641,
0.1173427477478981,
-0.04460182413458824,
0.07741906493902206,
0.10950449109077454,
-0.1397634595632553,
0.1611342877149582,
-0.0947628766298294,
-0.07003053277730942,
-0.11705468595027924,
0.15516604483127594,
-0.05690388008952141,
0.10266862064599991,
0.007421794347465038,
-0.05126748979091644,
-0.1646754890680313,
-0.13096311688423157,
0.15462878346443176,
-0.11793097853660583,
-0.27621832489967346,
0.01562267541885376,
0.03528027608990669,
0.17751088738441467,
-0.32643499970436096,
0.14712823927402496,
-0.047313231974840164,
0.09201812744140625,
-0.12097610533237457,
0.02189444750547409,
0.030169568955898285,
0.18116697669029236,
0.0442463755607605,
0.1257292926311493,
-0.1751987785100937,
0.17801979184150696,
-0.2712952196598053,
0.1057981550693512,
0.022172139957547188,
0.09557627141475677,
-0.20950528979301453,
-0.1106630489230156,
0.09005594998598099,
0.09703794121742249,
-0.014951326884329319,
0.05888768285512924,
0.0071046315133571625,
-0.012583361007273197,
0.021867794916033745,
-0.24982790648937225,
0.1284455806016922,
-0.07487811893224716,
0.10506640374660492,
-0.07358488440513611,
0.22311170399188995,
-0.054554663598537445,
-0.09712819010019302,
-0.09721504896879196,
0.14054422080516815,
-0.10011499375104904,
0.20044097304344177,
-0.0831964984536171,
0.2257731556892395,
-0.11993291974067688,
-0.024924160912632942,
0.08104288578033447,
-0.07387959957122803,
0.05969997122883797,
0.04068571701645851,
-0.20745037496089935,
0.19299565255641937,
0.04144800826907158,
-0.05615514516830444,
0.16053006052970886,
-0.10416785627603531,
0.08607707917690277,
-0.35072624683380127,
0.07109245657920837,
-0.11608681827783585,
-0.07705388218164444,
0.10112172365188599,
0.07538242638111115,
0.005974893923848867,
0.1595638394355774,
-0.04286910593509674,
-0.11264073103666306,
-0.1835159957408905,
0.18873295187950134,
0.160932719707489,
-0.048881568014621735,
0.05769927427172661,
0.13695842027664185,
-0.09202884882688522,
-0.053495049476623535,
-0.018936533480882645,
-0.1587374061346054,
0.16005641222000122,
-0.07483816146850586,
-0.24186846613883972,
-0.09903765469789505,
-0.09048888087272644,
0.05857452377676964,
0.24014349281787872,
0.01651179976761341,
0.03706861659884453,
0.32944822311401367,
-0.020630717277526855,
-0.07923965901136398,
-0.08344246447086334,
0.09588788449764252,
0.19713273644447327,
-0.09066668152809143,
-0.04258909821510315,
0.25584375858306885,
0.09040796756744385,
0.0710274949669838,
-0.16656312346458435,
0.04500420391559601,
-0.0830809473991394,
-0.02058962546288967,
-0.030362898483872414,
0.01926705427467823,
-0.016591668128967285,
0.16608774662017822,
-0.05791078880429268,
-0.17351165413856506,
-0.16027818620204926,
-0.10727032274007797,
-0.08434464782476425,
-0.039585601538419724,
0.21482793986797333,
-0.06270585209131241,
0.09071219712495804,
-0.07964279502630234,
-0.15969251096248627,
-0.039925530552864075,
0.08468633890151978,
-0.0819193571805954,
0.033961810171604156,
0.013273087330162525,
-0.17009323835372925,
0.05960332602262497,
0.08382028341293335,
-0.25541043281555176,
0.16215810179710388,
0.20691029727458954,
-0.041514188051223755,
-0.15688255429267883,
-0.028928324580192566,
-0.2888350784778595,
0.13820809125900269,
0.03263627737760544,
0.018377969041466713,
0.027888178825378418,
-0.02568640559911728,
-0.014863141812384129,
-0.01281274389475584,
0.07098954170942307,
0.17348389327526093,
0.04849301278591156,
-0.105946384370327,
0.10318183898925781,
0.11867357790470123,
-0.14789772033691406,
-0.10924418270587921,
-0.071551613509655,
0.01796375773847103,
0.18555934727191925,
0.12966252863407135,
-0.03459760919213295,
0.02460109256207943,
-0.14306464791297913,
0.10423209518194199,
-0.13596148788928986,
-0.20957772433757782,
0.1620393991470337,
-0.018200047314167023,
-0.13247960805892944,
-0.05952242761850357,
-0.06687090545892715,
-0.21639958024024963,
0.014916065149009228,
0.007835039868950844,
-0.17043037712574005,
0.03079194761812687
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. or no pathogenic variant is found.Targeted analysis for pathogenic variants. For Amish from Geauga County, Ohio and Druze and Arab Muslims from northern Israel, testing for the founder variants p.Arg265Ter and p.Ser202Phe, respectively, may be performed first followed by sequence analysis and gene-targeted deletion/duplication analysis if one or no pathogenic variant is identified.Table 2. Summary of Molecular Genetic Testing Used in Prolidase DeficiencyView in own windowGene 1Test MethodPathogenic Variants DetectedProportion of Probands with Pathogenic Variants 2 Detectable by This MethodPEPDSequence analysis 3Sequence variants28/30 4Gene-targeted deletion/duplication analysis 5Exon or whole-gene deletions2/30 4Targeted analysis for pathogenic variantsp.Arg265Ter4/4 6p.Ser202Phe17/20 71. See Table A. Genes and Databases for chromosome locus and | [
0.025456584990024567,
0.10674241930246353,
0.019434623420238495,
-0.1461528092622757,
0.13790959119796753,
0.09161725640296936,
0.08730506896972656,
-0.0459861196577549,
-0.043420638889074326,
-0.09296184778213501,
-0.026866314932703972,
0.21289023756980896,
0.19046612083911896,
0.026415543630719185,
-0.12352042645215988,
0.00964443851262331,
0.07109680771827698,
0.06709031760692596,
-0.03296788036823273,
0.017798839136958122,
0.0443088598549366,
-0.016292937099933624,
0.35586947202682495,
0.0030299939680844545,
0.07557012885808945,
-0.15682384371757507,
-0.010790850035846233,
0.010371452197432518,
-0.014483333565294743,
0.08990449458360672,
0.06538625061511993,
-0.08784020692110062,
0.006900656968355179,
-0.25708118081092834,
-0.07042932510375977,
-0.17576077580451965,
-0.03147169202566147,
0.033826928585767746,
0.2258831113576889,
-0.09590756893157959,
-0.030415931716561317,
-0.05329209938645363,
0.19797037541866302,
0.12378107011318207,
-0.012226582504808903,
-0.15040580928325653,
0.16065002977848053,
0.08603324741125107,
-0.09235677123069763,
0.08939118683338165,
0.083043672144413,
0.06788239628076553,
-0.05792411044239998,
-0.04204881191253662,
0.16974686086177826,
0.14915154874324799,
0.029958384111523628,
-0.02314435876905918,
-0.13256697356700897,
0.06558437645435333,
0.10968518257141113,
0.09043532609939575,
-0.20407076179981232,
-0.1642424464225769,
0.2585615813732147,
0.020698310807347298,
0.13917756080627441,
-0.10898306965827942,
0.008458901196718216,
-0.022882232442498207,
0.2555506229400635,
0.038533035665750504,
0.1976986527442932,
-0.03433628007769585,
-0.14055241644382477,
0.06868276745080948,
0.07700061798095703,
0.05612926930189133,
0.041872862726449966,
-0.2319447547197342,
-0.09590035676956177,
0.020456459373235703,
-0.0426330529153347,
0.14302708208560944,
-0.025841914117336273,
0.05153517797589302,
0.11192186176776886,
-0.016457127407193184,
0.07665731757879257,
0.03536597266793251,
0.05179585516452789,
-0.0036822641268372536,
0.07164038717746735,
0.01886947639286518,
-0.0038898196071386337,
-0.09550148248672485,
-0.02463531866669655,
0.001630889717489481,
-0.04845069348812103,
0.16333945095539093,
0.019795607775449753,
0.024252139031887054,
-0.10068219155073166,
-0.0059976293705403805,
0.1775342971086502,
-0.04782823100686073,
-0.10177304595708847,
-0.06637876480817795,
-0.003369513899087906,
-0.0399354062974453,
0.0646742582321167,
0.11446928977966309,
-0.03588525950908661,
-0.00927741453051567,
-0.07406026124954224,
0.11055493354797363,
0.11836765706539154,
0.029590850695967674,
-0.021257756277918816,
-0.018521437421441078,
0.0006997082382440567,
0.0240005049854517,
0.007052794098854065,
-0.09793506562709808,
0.009083813056349754,
0.006469754967838526,
0.07943089306354523,
0.043089207261800766,
0.19660213589668274,
-0.03098105639219284,
-0.0006192736327648163,
0.10230571776628494,
-0.019612733274698257,
-0.007810153067111969,
-0.07591375708580017,
-0.1539463847875595,
-0.21696951985359192,
-0.11061201989650726,
0.002884829882532358,
-0.11000503599643707,
0.07482670992612839,
0.028702007606625557,
0.14181548357009888,
0.11675378680229187,
-0.010751563124358654,
0.0826195627450943,
0.2445656806230545,
-0.06383831053972244,
-0.019430361688137054,
-0.025200484320521355,
-0.04402158409357071,
-0.15507586300373077,
0.34038808941841125,
-0.044083479791879654,
-0.08031813055276871,
-0.03362317755818367,
-0.12912015616893768,
0.13361160457134247,
-0.18253304064273834,
0.061159610748291016,
0.07684735953807831,
-0.0516170933842659,
0.05109589919447899,
-0.06476669758558273,
0.29791969060897827,
0.03573177382349968,
-0.058161865919828415,
0.12748967111110687,
0.058006372302770615,
0.1364392787218094,
-0.05335098132491112,
0.11064167320728302,
-0.0488276481628418,
0.07812070846557617,
0.13771939277648926,
-0.023896902799606323,
-0.1180943101644516,
-0.040518276393413544,
0.026705151423811913,
-0.14918340742588043,
-0.01347459014505148,
-0.011579472571611404,
-0.10097808390855789,
-0.07377644628286362,
-0.1856064349412918,
-0.03898612782359123,
0.030830781906843185,
0.17372600734233856,
0.00046326947631314397,
0.16308847069740295,
0.18978427350521088,
-0.009513026103377342,
-0.025741515681147575,
-0.11918240785598755,
0.21357472240924835,
-0.11304495483636856,
0.0713835284113884,
0.034356001764535904,
-0.08335480093955994,
-0.1794797033071518,
0.17463743686676025,
-0.10023372620344162,
-0.02339690551161766,
-0.0046713645569980145,
-0.03622683882713318,
0.011929687112569809,
0.045251522213220596,
0.0726417526602745,
-0.14227958023548126,
0.23586079478263855,
0.0835239514708519,
0.10497330129146576,
-0.09381245076656342,
0.23064930737018585,
0.031076524406671524,
-0.03745395317673683,
-0.08873862773180008,
-0.0964471772313118,
0.08125870674848557,
0.040830958634614944,
-0.009390910156071186,
0.052298691123723984,
-0.011339383199810982,
-0.1178254559636116,
0.06548707187175751,
0.0716143250465393,
-0.09755458682775497,
0.04575283080339432,
0.02234499901533127,
-0.008736140094697475,
0.07709561288356781,
-0.08183357119560242,
0.08423901349306107,
0.12137164920568466,
-0.24258412420749664,
0.013498073443770409,
0.0978039875626564,
0.0451054647564888,
0.11614597588777542,
0.013786925934255123,
-0.1324312537908554,
-0.05940382555127144,
-0.057141706347465515,
0.01656670682132244,
-0.06150592118501663,
0.05143626406788826,
-0.06495711952447891,
0.00934894010424614,
-0.08272045850753784,
0.004503707401454449,
-0.12466514110565186,
0.06862561404705048,
0.06561753153800964,
-0.1263674944639206,
-0.4139871895313263,
0.02822384051978588,
0.03333123400807381,
-0.043191079050302505,
0.009765883907675743,
0.04596789553761482,
0.028158482164144516,
-0.013901863247156143,
0.07810287922620773,
0.045785870403051376,
0.04159926623106003,
0.014444834552705288,
-0.2302200049161911,
0.016571395099163055,
-0.10607411712408066,
-0.19422951340675354,
-0.0552496463060379,
0.058083053678274155,
0.09340847283601761,
0.11116359382867813,
-0.04366903752088547,
-0.035017382353544235,
-0.045779913663864136,
0.0017578140832483768,
0.014355482533574104,
0.007780567742884159,
-0.09371179342269897,
0.039787136018276215,
-0.13785983622074127,
0.005040972027927637,
0.08138329535722733,
-0.07226250320672989,
0.13238932192325592,
0.034037455916404724,
-0.09994933754205704,
0.10269062966108322,
0.1684531271457672,
0.09362442046403885,
-0.10294392704963684,
0.03141500800848007,
0.006585768423974514,
0.09578690677881241,
0.0016946302494034171,
0.023365549743175507,
0.09753835201263428,
-0.05270978808403015,
0.14338922500610352,
-0.05260331556200981,
0.01618080586194992,
-0.13600467145442963,
-0.12885431945323944,
-0.02150403894484043,
-0.03901435434818268,
0.04801895096898079,
-0.0959232971072197,
0.16535279154777527,
-0.2124052494764328,
0.10272087156772614,
-0.2747257947921753,
-0.15029418468475342,
0.06699981540441513,
0.02598789893090725,
-0.155564084649086,
0.13733260333538055,
0.029213614761829376,
0.15489736199378967,
0.18049797415733337,
-0.042887020856142044,
0.11390352249145508,
0.12962459027767181,
-0.06131650134921074,
-0.08277051150798798,
-0.2600664794445038,
-0.043889179825782776,
0.07570075243711472,
0.03712381422519684,
0.017488114535808563,
0.009622507728636265,
0.0352376289665699,
-0.03271710127592087,
0.035786282271146774,
0.05828453227877617,
0.1359604001045227,
-0.09207130968570709,
-0.13318030536174774,
0.008032169193029404,
0.04014929383993149,
-0.13702256977558136,
-0.15694327652454376,
0.09992983192205429,
-0.06974554061889648,
-0.06339285522699356,
0.038898780941963196,
-0.21809932589530945,
0.08570505678653717,
-0.12826283276081085,
0.02683490328490734,
0.005271408706903458,
0.01088241022080183,
-0.14277148246765137,
0.2371998429298401,
0.13372448086738586,
-0.047525811940431595,
0.04499369114637375,
0.058962542563676834,
-0.08897894620895386,
-0.08174454420804977,
0.07308190315961838,
0.17173965275287628,
-0.07375052571296692,
0.09419412165880203,
0.006204354111105204,
0.1293976604938507,
0.1814575344324112,
0.07841745018959045,
0.14308035373687744,
0.012632296420633793,
0.11702204495668411,
0.09984242171049118,
0.1693677306175232,
-0.056972090154886246,
0.05619819462299347,
-0.034464891999959946,
0.13733801245689392,
-0.04171998053789139,
-0.07841910421848297,
0.09890609234571457,
-0.08720022439956665,
0.16514290869235992,
0.09538911283016205,
0.030177826061844826,
0.23475593328475952,
-0.08560612797737122,
-0.08750330656766891,
0.044357605278491974,
-0.019024597480893135,
0.0340735986828804,
0.18322627246379852,
0.086057148873806,
-0.08520149439573288,
-0.14607085287570953,
0.15233689546585083,
-0.11597041040658951,
-0.03332949057221413,
-0.13379475474357605,
-0.04920518770813942,
-0.11848092079162598,
-0.13702881336212158,
-0.03378026559948921,
0.10804827511310577,
-0.06476292014122009,
0.10492048412561417,
0.056117624044418335,
0.12444772571325302,
0.060156114399433136,
-0.1032562330365181,
0.17933771014213562,
0.058170776814222336,
-0.055354636162519455,
0.004742567427456379,
-0.12628187239170074,
-0.010772704146802425,
0.048324983566999435,
0.0414922833442688,
0.04644344002008438,
0.08780750632286072,
-0.1395014375448227,
0.09517922252416611,
0.16592812538146973,
-0.05241497606039047,
0.014096573926508427,
-0.08958933502435684,
0.12417980283498764,
0.024513885378837585,
0.010872128419578075,
0.038491275161504745,
0.07104845345020294,
0.1256369948387146,
-0.017516665160655975,
-0.024478977546095848,
0.1420561671257019,
0.0504639632999897,
0.21952839195728302,
-0.09606005251407623,
0.19981390237808228,
0.07402611523866653,
0.1727236807346344,
0.10873179882764816,
-0.2445451319217682,
-0.0642036646604538,
-0.054156526923179626,
0.15761998295783997,
0.061616621911525726,
0.08342025429010391,
-0.024440515786409378,
0.06903820484876633,
0.051610320806503296,
-0.06596231460571289,
-0.07364103943109512,
-0.08359606564044952,
-0.10825078934431076,
0.0032240143045783043,
-0.06434956938028336,
-0.07513047754764557,
-0.028955422341823578,
-0.1425776481628418,
-0.0017402590019628406,
0.22672326862812042,
0.04601869732141495,
-0.04914974421262741,
0.010671176016330719,
-0.11141425371170044,
0.0008209384395740926,
-0.03067041002213955,
0.21891771256923676,
-0.09523487836122513,
0.16766244173049927,
-0.0016182741383090615,
-0.07021348923444748,
-0.10865496098995209,
-0.16840103268623352,
0.00029350537806749344,
0.050607889890670776,
0.008283425122499466,
0.02338910475373268,
-0.05704275518655777,
-0.08798493444919586,
-0.0278480164706707,
-0.1714620590209961,
-0.14951905608177185,
-0.049826957285404205,
0.07605323195457458,
0.18745601177215576,
-0.15718963742256165,
-0.0865425318479538,
0.036178331822156906,
-0.043835971504449844,
0.15489062666893005,
0.06582561135292053,
0.1734500676393509,
-0.05287684500217438,
-0.16188105940818787,
0.00036700692726299167,
-0.06678669154644012,
-0.12316634505987167,
-0.17875240743160248,
-0.04763622581958771,
0.008189387619495392,
0.09750563651323318,
0.16752052307128906,
0.02299915812909603,
-0.0834769606590271,
0.05075560137629509,
-0.1454823762178421,
0.07678858190774918,
0.18363438546657562,
0.06575926393270493,
0.028559427708387375,
-0.07370965927839279,
-0.091181181371212,
-0.06318021565675735,
-0.1582648605108261,
0.04444146528840065,
-0.0540248267352581,
0.10130041092634201,
-0.08669493347406387,
0.13503021001815796,
-0.19954074919223785,
0.035924386233091354,
0.1141144335269928,
0.005614650901407003,
-0.24541597068309784,
0.005300793331116438,
0.04213637858629227,
-0.02978092059493065,
-0.12460380792617798,
-0.15933601558208466,
0.04107515886425972,
-0.14123660326004028,
0.060797709971666336,
-0.053885504603385925,
0.04691917821764946,
-0.052748095244169235,
-0.11043783277273178,
-0.14375567436218262,
-0.1391756236553192,
-0.04693533480167389,
-0.03507556393742561,
0.017575489357113838,
-0.000497535103932023,
-0.0012161293998360634,
0.139860138297081,
0.0579892136156559,
-0.07875873893499374,
0.10071761906147003,
-0.0029448282439261675,
-0.11132705956697464,
-0.037996988743543625,
-0.011627345345914364,
0.06026916205883026,
-0.16065433621406555,
-0.011038975790143013,
-0.05660918354988098,
-0.0947408676147461,
-0.09440291672945023,
0.09876204282045364,
-0.07447470724582672,
0.021625829860568047,
-0.10457196831703186,
-0.09016090631484985,
-0.049867238849401474,
0.267508864402771,
0.030944667756557465,
-0.12536796927452087,
0.13318005204200745,
-0.09141424298286438,
-0.24211160838603973,
-0.03670931234955788,
0.11358257383108139,
-0.075088270008564,
-0.19711865484714508,
-0.14213839173316956,
-0.08372144401073456,
-0.08554248511791229,
-0.10456707328557968,
0.066266730427742,
-0.06397147476673126,
-0.1436753273010254,
-0.11218244582414627,
0.09710372239351273,
0.06922800838947296,
0.15013162791728973,
-0.018333768472075462,
-0.04175916686654091,
0.0426538847386837,
-0.07855333387851715,
0.09302344173192978,
-0.03395455330610275,
-0.028452349826693535,
-0.07765918225049973,
0.0357079952955246,
0.043149594217538834,
0.08684181421995163,
0.029536696150898933,
-0.06470964848995209,
-0.08177733421325684,
-0.21761058270931244,
0.1346409022808075,
-0.045160211622714996,
-0.19832637906074524,
0.062344990670681,
0.05282027646899223,
0.05137812718749046,
-0.2682498097419739,
0.13326235115528107,
-0.11189020425081253,
0.030980704352259636,
-0.14261595904827118,
0.051032233983278275,
-0.018861323595046997,
0.22585277259349823,
0.051726941019296646,
0.11612211912870407,
-0.05041338875889778,
0.10129433125257492,
-0.17022770643234253,
0.13748571276664734,
0.020623888820409775,
0.08886554092168808,
-0.1816253513097763,
-0.017821501940488815,
0.03700028732419014,
0.10083211213350296,
-0.009099840186536312,
0.07345299422740936,
-0.05507143959403038,
-0.0823010578751564,
0.008053687401115894,
-0.12636134028434753,
0.013943472877144814,
-0.03256220743060112,
0.12841403484344482,
-0.08997440338134766,
0.16973955929279327,
0.030149703845381737,
-0.1019228845834732,
0.004068460315465927,
0.026624692603945732,
-0.06650708615779877,
0.07758163660764694,
-0.08263576775789261,
0.16984997689723969,
-0.07854347676038742,
-0.04748491570353508,
0.139633908867836,
-0.005754529032856226,
0.021751325577497482,
0.09644854068756104,
-0.15429192781448364,
0.13434475660324097,
-0.0419805571436882,
-0.10015682131052017,
0.0506657175719738,
-0.00006576506712008268,
0.07324178516864777,
-0.28550446033477783,
0.03192278742790222,
-0.09955813735723495,
-0.08375650644302368,
0.06131487712264061,
0.1252882480621338,
0.002602463588118553,
0.04313427954912186,
-0.04307384788990021,
0.03050801530480385,
-0.14123673737049103,
0.06872113049030304,
0.028159238398075104,
0.06310476362705231,
0.0024882324505597353,
0.055393632501363754,
-0.01561394426971674,
-0.007510290015488863,
0.10390205681324005,
-0.06504813581705093,
0.14991046488285065,
-0.09106148779392242,
-0.18406085669994354,
0.022884907200932503,
0.029460400342941284,
-0.005858300253748894,
0.1991046518087387,
-0.08607272803783417,
-0.026706725358963013,
0.2593427300453186,
-0.05182835832238197,
-0.09672035276889801,
-0.09657196700572968,
0.05769616737961769,
0.15647479891777039,
-0.02187655121088028,
0.006079083774238825,
0.1884453147649765,
0.1810775101184845,
0.051715027540922165,
-0.15068143606185913,
0.07250960916280746,
-0.10248736292123795,
0.06348225474357605,
0.05195283144712448,
-0.009052740409970284,
-0.016864033415913582,
0.11881295591592789,
-0.12315261363983154,
-0.07145008444786072,
-0.03686130791902542,
-0.07149673998355865,
-0.07010577619075775,
0.07594546675682068,
0.1492055207490921,
-0.09785957634449005,
0.09469032287597656,
0.05117230862379074,
-0.05908351019024849,
-0.0782623291015625,
0.07603271305561066,
-0.05312103033065796,
0.007974762469530106,
-0.025465739890933037,
-0.12571454048156738,
0.09852907806634903,
0.10716084390878677,
-0.19711460173130035,
0.09457265585660934,
0.13355359435081482,
-0.060978904366493225,
-0.09199301153421402,
-0.051240310072898865,
-0.18263007700443268,
0.10472162067890167,
0.038982730358839035,
0.09964591264724731,
0.02529643289744854,
0.054879944771528244,
0.03418958559632301,
-0.040858954191207886,
0.08724871277809143,
0.06540884077548981,
0.07784844189882278,
-0.10619976371526718,
0.11282207071781158,
0.09383947402238846,
-0.05145866051316261,
-0.09787880629301071,
-0.04886035993695259,
0.05410810187458992,
0.2602333724498749,
0.21204118430614471,
-0.06054835021495819,
-0.03540250286459923,
-0.05972060561180115,
0.04951732978224754,
-0.0619937926530838,
-0.16965234279632568,
0.059378497302532196,
-0.06566134840250015,
-0.05580119416117668,
0.061404988169670105,
-0.05959608778357506,
-0.06511404365301132,
-0.03793684020638466,
0.05423697456717491,
-0.10653570294380188,
0.04319753125309944
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. idase DeficiencyView in own windowGene 1Test MethodPathogenic Variants DetectedProportion of Probands with Pathogenic Variants 2 Detectable by This MethodPEPDSequence analysis 3Sequence variants28/30 4Gene-targeted deletion/duplication analysis 5Exon or whole-gene deletions2/30 4Targeted analysis for pathogenic variantsp.Arg265Ter4/4 6p.Ser202Phe17/20 71. See Table A. Genes and Databases for chromosome locus and protein.2. See Molecular Genetics for information on allelic variants detected in this gene.3. Sequence analysis detects variants that are benign, likely benign, of uncertain significance, likely pathogenic, or pathogenic. Pathogenic variants may include small intragenic deletions/insertions and missense, nonsense, and splice site variants; typically, exon or whole-gene deletions/duplications are not detected. For issues to consider in interpretation of sequence analysis results, click here.4. Lupi et al | [
0.07277050614356995,
0.0965605080127716,
0.012285010889172554,
-0.06922807544469833,
0.10377119481563568,
-0.045733172446489334,
0.04764382913708687,
0.01098873931914568,
-0.09988445043563843,
-0.12053392082452774,
0.09676934778690338,
0.17576028406620026,
0.1591547429561615,
-0.0035090786404907703,
-0.16231469810009003,
0.021781161427497864,
0.033936697989702225,
0.046222709119319916,
-0.09626705944538116,
0.0683102160692215,
0.10641856491565704,
-0.023351432755589485,
0.2678830623626709,
0.0434541217982769,
0.03508852794766426,
-0.09888961166143417,
0.0578816682100296,
0.05722139775753021,
0.003953657578676939,
0.07868178188800812,
0.12832224369049072,
-0.04577195644378662,
0.04846751689910889,
-0.269893616437912,
-0.04473773390054703,
-0.26548486948013306,
-0.08931052684783936,
0.052647221833467484,
0.1585889309644699,
-0.03790038451552391,
0.04211891070008278,
-0.07336626946926117,
0.09202584624290466,
0.1417444348335266,
-0.030596766620874405,
-0.1506643295288086,
0.09105418622493744,
0.0554518960416317,
-0.07305159419775009,
0.11849651485681534,
0.02984129637479782,
0.010419082827866077,
0.017155829817056656,
-0.020936718210577965,
0.1561027616262436,
0.08634139597415924,
-0.03511723130941391,
-0.04495444521307945,
-0.16738441586494446,
-0.0010151908500120044,
0.10641059279441833,
0.09691876918077469,
-0.16818542778491974,
-0.1975947469472885,
0.28722643852233887,
-0.04304420202970505,
0.10143553465604782,
-0.09321092814207077,
0.10037022829055786,
-0.05277848616242409,
0.21795377135276794,
0.017812199890613556,
0.11860260367393494,
0.015121209435164928,
-0.12824904918670654,
0.00703958747908473,
0.11829299479722977,
0.08624455332756042,
0.061110273003578186,
-0.27267053723335266,
-0.015454730950295925,
-0.024803470820188522,
-0.06869269162416458,
0.11431148648262024,
0.02630903385579586,
-0.05787483975291252,
0.07028981298208237,
-0.0632922500371933,
0.09915167093276978,
0.012034783139824867,
-0.057803839445114136,
0.02989589236676693,
0.12289363145828247,
0.13190339505672455,
0.017972270026803017,
-0.14836131036281586,
-0.11502149701118469,
0.08859790861606598,
0.013839458115398884,
0.14039207994937897,
-0.02158745937049389,
0.04250020906329155,
-0.18012261390686035,
-0.018574578687548637,
0.23750953376293182,
-0.023734522983431816,
-0.051019806414842606,
-0.04840554669499397,
-0.03136274591088295,
0.0035255933180451393,
-0.01896711438894272,
0.07452155649662018,
0.011254984885454178,
-0.04654951021075249,
-0.08772319555282593,
0.09247997403144836,
0.1183587834239006,
0.012747601605951786,
-0.02460426278412342,
-0.020618248730897903,
-0.01705118827521801,
0.0060568698681890965,
-0.007700372952967882,
0.006368914619088173,
0.08141762018203735,
-0.07598654925823212,
0.12162800878286362,
0.07006367295980453,
0.15899989008903503,
-0.03039689175784588,
-0.0035946222487837076,
0.13405296206474304,
-0.041020188480615616,
-0.019961314275860786,
-0.04076963663101196,
-0.08292535692453384,
-0.2393839955329895,
-0.10940653830766678,
0.03962644562125206,
-0.07580922544002533,
0.07428839057683945,
0.07453448325395584,
0.12956489622592926,
0.10217341035604477,
0.09079556912183762,
0.08843252062797546,
0.22718244791030884,
-0.10579872876405716,
-0.0921793058514595,
-0.008768458850681782,
-0.05859829857945442,
-0.10745086520910263,
0.35866841673851013,
-0.08391432464122772,
-0.08831208944320679,
-0.052717242389917374,
-0.06377328187227249,
0.07847519963979721,
-0.184317946434021,
0.03188648819923401,
0.1087966188788414,
-0.02990914322435856,
0.10876292735338211,
-0.1105247437953949,
0.22264517843723297,
0.0750696212053299,
0.00731288967654109,
0.10566915571689606,
0.05576581880450249,
0.09784377366304398,
-0.06402783840894699,
0.03242889419198036,
-0.025561252608895302,
0.032798849046230316,
0.07286214083433151,
0.02888428047299385,
-0.026566945016384125,
-0.03509243577718735,
-0.013797394931316376,
-0.21692140400409698,
0.01795274205505848,
-0.04680078476667404,
-0.07919624447822571,
-0.12482111901044846,
-0.16276851296424866,
-0.08448655158281326,
0.014593521133065224,
0.24116210639476776,
-0.08641841262578964,
0.23569318652153015,
0.21196453273296356,
0.013167842291295528,
-0.054630864411592484,
-0.14455865323543549,
0.11267241835594177,
-0.14820647239685059,
0.1355350762605667,
0.15146949887275696,
-0.09238861501216888,
-0.07318469136953354,
0.17950986325740814,
0.04037421941757202,
-0.1280589997768402,
-0.01738983578979969,
-0.04337974637746811,
-0.007970035076141357,
0.07257521897554398,
0.12904982268810272,
-0.1518101841211319,
0.23410901427268982,
0.03921709209680557,
0.033973630517721176,
-0.05298779159784317,
0.1997164934873581,
0.04592534527182579,
-0.10856178402900696,
-0.008663611486554146,
-0.07538333535194397,
0.020869355648756027,
0.041128505021333694,
-0.011055339127779007,
0.026877500116825104,
-0.042238444089889526,
-0.10521495342254639,
0.15431258082389832,
-0.005067127291113138,
-0.11104456335306168,
0.011856784112751484,
-0.05800464376807213,
-0.047739427536726,
0.05939109995961189,
-0.048488833010196686,
0.0350174680352211,
0.0993565246462822,
-0.272005170583725,
0.03150762990117073,
0.08676672726869583,
0.0885000228881836,
0.013241360895335674,
0.03315000608563423,
-0.1081637367606163,
-0.06110173091292381,
-0.029422560706734657,
0.040694158524274826,
-0.05423644557595253,
0.04429514333605766,
-0.005042603705078363,
-0.006065076217055321,
-0.06685450673103333,
0.05670856311917305,
-0.05637391656637192,
0.07801126688718796,
-0.006380092818289995,
-0.09303689748048782,
-0.42854732275009155,
0.07064890116453171,
0.07775955647230148,
0.026861296966671944,
0.01250141765922308,
0.050297532230615616,
0.03676554188132286,
0.13475452363491058,
0.03526300936937332,
-0.009604047983884811,
-0.010785715654492378,
0.014361966401338577,
-0.2063473016023636,
-0.07086329907178879,
-0.025376958772540092,
-0.19569502770900726,
-0.19407124817371368,
0.06691132485866547,
0.0019225950818508863,
0.08260788023471832,
-0.02238885685801506,
-0.007964182645082474,
-0.008604644797742367,
-0.11099227517843246,
0.0552082359790802,
0.032712481915950775,
-0.03408088907599449,
0.012542087584733963,
-0.10523907840251923,
-0.014342337846755981,
0.04430616647005081,
-0.06648272275924683,
0.09619728475809097,
0.12513257563114166,
0.05213429406285286,
0.11563573777675629,
0.13095398247241974,
0.12573561072349548,
-0.05859312787652016,
0.000592280994169414,
-0.09158244729042053,
0.06621801108121872,
-0.01940409280359745,
0.034824758768081665,
0.06896273791790009,
-0.05333296209573746,
0.03621678054332733,
-0.1006280779838562,
-0.05276486650109291,
-0.14259128272533417,
-0.06353364139795303,
-0.04851176589727402,
-0.07230331748723984,
0.09660157561302185,
-0.04809126257896423,
0.10118286311626434,
-0.16678018867969513,
0.06573119014501572,
-0.1727544665336609,
-0.05916009098291397,
0.01473069004714489,
0.053876761347055435,
-0.06638757884502411,
0.0804067924618721,
0.013230801559984684,
0.1339873969554901,
0.12956033647060394,
-0.045434027910232544,
0.22080008685588837,
0.2318219542503357,
-0.01888464204967022,
-0.07751620560884476,
-0.27240046858787537,
-0.050237931311130524,
-0.05141127109527588,
0.031750138849020004,
-0.055965133011341095,
-0.03708920255303383,
0.0274376068264246,
-0.04279990866780281,
-0.06559547781944275,
0.008653606288135052,
0.17795133590698242,
-0.01577841490507126,
-0.08941646665334702,
-0.02793583832681179,
0.1023644283413887,
-0.19345064461231232,
-0.13007192313671112,
0.18298578262329102,
-0.042397644370794296,
-0.0010230481857433915,
-0.0015603724168613553,
-0.18248064815998077,
0.0739719495177269,
-0.08044490218162537,
-0.019228171557188034,
-0.060245294123888016,
-0.043615490198135376,
-0.13103371858596802,
0.17228981852531433,
0.16301091015338898,
0.055337704718112946,
0.005170534830540419,
-0.03489524498581886,
-0.11367811262607574,
-0.041603561490774155,
0.060139480978250504,
0.04939546808600426,
0.008417021483182907,
0.024969900026917458,
-0.016340110450983047,
0.014079775661230087,
0.09838386625051498,
0.04665353149175644,
0.1568944752216339,
0.077788807451725,
0.2111494541168213,
0.08936550468206406,
0.055011942982673645,
-0.029331857338547707,
0.015678858384490013,
-0.07972723245620728,
0.07670879364013672,
0.004244231153279543,
0.06355998665094376,
0.18853197991847992,
-0.0005525978049263358,
0.19569046795368195,
0.017253391444683075,
0.015550671145319939,
0.200786754488945,
-0.15550675988197327,
-0.008542642928659916,
0.016465628519654274,
-0.06729455292224884,
0.0662645772099495,
0.1515771448612213,
0.11346016079187393,
-0.05788974463939667,
-0.10552810877561569,
0.21481846272945404,
-0.21119152009487152,
-0.03759126365184784,
-0.04089225456118584,
-0.02261689305305481,
-0.16861490905284882,
-0.1471160501241684,
-0.01820104382932186,
0.1075725257396698,
0.0064451913349330425,
0.08046451210975647,
0.018676767125725746,
0.10343031585216522,
0.052349239587783813,
-0.0028233921620994806,
0.07098186761140823,
0.08722565323114395,
-0.1108904480934143,
-0.06733328104019165,
-0.20469684898853302,
-0.008177320472896099,
0.05857463181018829,
0.035749197006225586,
0.05349061265587807,
0.03567519038915634,
-0.10013063251972198,
0.047418996691703796,
0.20502598583698273,
0.03832598775625229,
0.053404003381729126,
-0.11057574301958084,
0.03937087580561638,
0.14563214778900146,
0.02900763787329197,
0.02510933019220829,
0.1383708119392395,
0.12547163665294647,
-0.010730337351560593,
0.044239651411771774,
0.05730145052075386,
-0.05498470366001129,
0.18754370510578156,
-0.14932838082313538,
0.3365539610385895,
-0.010455284267663956,
0.1786213219165802,
0.1345011442899704,
-0.24715735018253326,
0.006093207281082869,
0.008289806544780731,
0.09257352352142334,
0.067329041659832,
0.014258245937526226,
-0.06649882346391678,
0.07960930466651917,
0.032957181334495544,
-0.04104367271065712,
-0.05360989272594452,
-0.1280430108308792,
-0.023285746574401855,
0.04646916687488556,
-0.06739062815904617,
-0.09641775488853455,
-0.16617752611637115,
-0.13332444429397583,
-0.012030965648591518,
0.1450899988412857,
0.07012620568275452,
-0.06495614349842072,
0.0517265647649765,
-0.11726398766040802,
0.09078946709632874,
-0.03129393234848976,
0.2346755862236023,
-0.012012341991066933,
0.09173320233821869,
-0.04296484589576721,
-0.048163559287786484,
-0.05810661241412163,
-0.16914154589176178,
-0.08985716104507446,
0.06577738374471664,
-0.030648402869701385,
0.0312928631901741,
-0.04508623853325844,
-0.14190374314785004,
0.08116171509027481,
-0.13476404547691345,
-0.2256516069173813,
-0.002047351561486721,
0.058304961770772934,
0.12744492292404175,
-0.07293228060007095,
-0.1178411915898323,
0.02349088154733181,
-0.04046154394745827,
0.1694198101758957,
0.09538132697343826,
0.114481121301651,
-0.0794052928686142,
-0.1689228117465973,
-0.1331729143857956,
-0.014971667900681496,
-0.061139967292547226,
-0.1586928367614746,
-0.025626173242926598,
0.052044451236724854,
0.07188484072685242,
0.03919443488121033,
0.03193099796772003,
-0.08897162228822708,
0.0918426439166069,
-0.21854710578918457,
0.07844490557909012,
0.14134812355041504,
0.012901080772280693,
0.012218311429023743,
-0.059281911700963974,
-0.1465642899274826,
-0.006444378290325403,
-0.20117387175559998,
0.06327654421329498,
-0.10928241163492203,
0.09321147948503494,
-0.14343369007110596,
0.12018965929746628,
-0.20649300515651703,
0.08421622961759567,
-0.0011684253113344312,
-0.044748708605766296,
-0.23075725138187408,
-0.0489497110247612,
0.08946297317743301,
-0.030215125530958176,
-0.14489232003688812,
-0.1120653972029686,
-0.014560104347765446,
-0.18892671167850494,
0.04554084315896034,
-0.08084140717983246,
0.10169368237257004,
0.04727185517549515,
-0.0625167042016983,
-0.2188754826784134,
-0.08276671171188354,
-0.007209325209259987,
0.0635257139801979,
0.04529135301709175,
0.027668887749314308,
0.056477274745702744,
0.019503748044371605,
0.03800805285573006,
-0.07060473412275314,
0.19440606236457825,
0.005524894222617149,
-0.02421700209379196,
-0.07717356085777283,
-0.04270656034350395,
-0.010742668062448502,
-0.20469383895397186,
0.03715158626437187,
0.003068357240408659,
-0.05584633722901344,
-0.017211589962244034,
0.15841223299503326,
-0.19376175105571747,
0.08532099425792694,
-0.08446528017520905,
-0.057905036956071854,
0.028289111331105232,
0.28991031646728516,
0.0031911670230329037,
-0.012673825025558472,
0.10802682489156723,
0.03775065392255783,
-0.25648942589759827,
-0.09462838619947433,
0.08976923674345016,
0.14648084342479706,
-0.13202086091041565,
-0.03219559043645859,
-0.14453062415122986,
-0.11673833429813385,
-0.18126967549324036,
0.012072603218257427,
-0.08298352360725403,
-0.17604507505893707,
0.007818140089511871,
-0.04424355924129486,
0.10185600817203522,
0.1576499044895172,
0.010180910117924213,
-0.05061179772019386,
0.034804072231054306,
-0.07568997144699097,
0.08908753842115402,
-0.0562017597258091,
-0.05233197659254074,
-0.06602492928504944,
-0.07322441041469574,
0.07161939889192581,
0.09382865577936172,
0.08633115887641907,
-0.03205585852265358,
-0.05867889150977135,
-0.17481276392936707,
0.10939279943704605,
-0.020467033609747887,
-0.1857210099697113,
0.04431445896625519,
0.018735429272055626,
0.053937360644340515,
-0.28379419445991516,
0.19454452395439148,
-0.1543540209531784,
0.03518477454781532,
-0.16496527194976807,
-0.011785936541855335,
-0.05358413606882095,
0.3138837516307831,
0.004924201872199774,
0.12494979053735733,
-0.02295268140733242,
0.12810376286506653,
-0.11416307836771011,
0.16392289102077484,
-0.04649507999420166,
0.09132786095142365,
-0.17107105255126953,
-0.059069156646728516,
0.09444422274827957,
0.1193886399269104,
-0.039439886808395386,
-0.004006189294159412,
-0.07367198169231415,
-0.0002815873012878001,
-0.05998098477721214,
-0.12422303855419159,
0.050784267485141754,
-0.05754163861274719,
0.013614577241241932,
-0.06573078036308289,
0.09116590023040771,
0.07918036729097366,
-0.12180756032466888,
0.03242040053009987,
-0.02639204077422619,
0.0276882853358984,
0.16532106697559357,
-0.04633340984582901,
0.10248298197984695,
-0.15330129861831665,
-0.13276709616184235,
0.11829295754432678,
0.014201447367668152,
0.04102290794253349,
0.08522526174783707,
-0.2372681349515915,
0.11038210988044739,
0.0007154452614486217,
-0.17286020517349243,
0.027419060468673706,
-0.05719337984919548,
0.10104693472385406,
-0.16720367968082428,
0.009215792641043663,
-0.09809982776641846,
-0.14630238711833954,
-0.022658007219433784,
0.1424373984336853,
0.04626985266804695,
0.020047824829816818,
-0.0881788581609726,
0.09015972167253494,
-0.1689235121011734,
0.09929683804512024,
-0.025000523775815964,
0.0879824087023735,
0.033251646906137466,
-0.012680447660386562,
0.0664999783039093,
-0.021531425416469574,
0.10975997895002365,
-0.02629617042839527,
0.21090054512023926,
-0.09606542438268661,
-0.20253004133701324,
0.06012583523988724,
0.029144426807761192,
-0.048111360520124435,
0.16716215014457703,
-0.005371564533561468,
0.048939455300569534,
0.15761315822601318,
-0.04663299769163132,
-0.11391732841730118,
-0.050109341740608215,
0.021278705447912216,
0.08056188374757767,
-0.02879502810537815,
-0.05437914654612541,
0.3382736146450043,
0.2002812772989273,
0.015575611032545567,
-0.05389443039894104,
0.10530281066894531,
-0.07055589556694031,
0.0900021567940712,
0.021913845092058182,
0.03775818645954132,
-0.05170474201440811,
0.13773752748966217,
-0.1812102049589157,
-0.018617767840623856,
-0.13748908042907715,
-0.02125028893351555,
-0.08153379708528519,
0.20537874102592468,
0.13320742547512054,
-0.05307041481137276,
0.05200257897377014,
0.08465456962585449,
-0.08647990226745605,
-0.08308396488428116,
0.020655522122979164,
-0.08696399629116058,
-0.021913999691605568,
-0.08771584928035736,
-0.1465502381324768,
0.11767397075891495,
0.14003095030784607,
-0.2398800551891327,
0.2516939640045166,
0.10278860479593277,
-0.07767603546380997,
-0.013550407253205776,
0.004103712737560272,
-0.14231720566749573,
0.07775169610977173,
0.06973353028297424,
0.07132598012685776,
-0.02899021841585636,
0.007675390224903822,
0.06268469244241714,
-0.04288097843527794,
0.12519845366477966,
-0.0902010127902031,
-0.021700628101825714,
-0.08144143968820572,
0.06710062175989151,
0.09016230702400208,
-0.033198997378349304,
-0.13841751217842102,
-0.07192837446928024,
0.009340072050690651,
0.20485128462314606,
0.28166285157203674,
0.03024580143392086,
-0.018901202827692032,
-0.08633136004209518,
0.13246217370033264,
-0.029516559094190598,
-0.09324833005666733,
-0.08725138008594513,
-0.006205670069903135,
-0.04057750850915909,
-0.01188749261200428,
-0.0377742275595665,
0.004656702280044556,
0.042681511491537094,
0.06958223879337311,
-0.09987332671880722,
-0.07488454133272171
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. and Databases for chromosome locus and protein.2. See Molecular Genetics for information on allelic variants detected in this gene.3. Sequence analysis detects variants that are benign, likely benign, of uncertain significance, likely pathogenic, or pathogenic. Pathogenic variants may include small intragenic deletions/insertions and missense, nonsense, and splice site variants; typically, exon or whole-gene deletions/duplications are not detected. For issues to consider in interpretation of sequence analysis results, click here.4. Lupi et al 5. Gene-targeted deletion/duplication analysis detects intragenic deletions or duplications. Methods used may include: quantitative PCR, long-range PCR, multiplex ligation-dependent probe amplification (MLPA), and gene-targeted microarray designed to detect single-exon deletions or duplications.6. Amish from Geauga County, Ohio 7. Druze and Arab Muslims from northern Israel Measurement of prolidase enzyme activity. In affected individuals, prolidase enzyme | [
0.017299871891736984,
0.13406114280223846,
0.01436404325067997,
0.029710331931710243,
0.1414124071598053,
-0.05764351412653923,
0.05644272640347481,
-0.02274625189602375,
-0.002195127308368683,
-0.10819511115550995,
0.12994299829006195,
0.13852755725383759,
0.16335777938365936,
-0.0438060536980629,
-0.16082139313220978,
0.046414345502853394,
0.02246522158384323,
-0.013151522725820541,
-0.07369490712881088,
0.09410928189754486,
0.09549479186534882,
-0.06290502101182938,
0.34847864508628845,
0.06383433192968369,
0.1279177963733673,
-0.15129955112934113,
0.09151814132928848,
0.02494773082435131,
-0.026489615440368652,
0.050357747822999954,
0.16373834013938904,
-0.030333396047353745,
0.021453725174069405,
-0.3104780614376068,
0.045133206993341446,
-0.19120559096336365,
-0.11119930446147919,
0.07930286228656769,
0.17557860910892487,
-0.014232064597308636,
0.003139626933261752,
0.014679419808089733,
0.05324146896600723,
0.11813854426145554,
0.01840953715145588,
-0.19719688594341278,
0.08488500863313675,
0.06175585463643074,
-0.15656308829784393,
0.07555138319730759,
0.0889459177851677,
-0.08118459582328796,
0.033358268439769745,
-0.0852329432964325,
0.22731801867485046,
0.20249348878860474,
-0.06113102659583092,
-0.06775287538766861,
-0.18051984906196594,
-0.03353448584675789,
-0.043891891837120056,
-0.008567417040467262,
-0.2165650576353073,
-0.3060757517814636,
0.3332180678844452,
-0.12814785540103912,
0.14039205014705658,
-0.12578918039798737,
0.06618252396583557,
0.04781780019402504,
0.315805047750473,
-0.04776441678404808,
0.18475143611431122,
0.016877315938472748,
-0.15507714450359344,
0.015036522410809994,
0.12242243438959122,
0.08423954248428345,
0.10494647175073624,
-0.25052598118782043,
-0.041318055242300034,
0.0000854807803989388,
-0.15793700516223907,
0.199144646525383,
0.0934046283364296,
-0.10780969262123108,
0.03317263349890709,
-0.03995989263057709,
0.05449161306023598,
-0.01066381111741066,
-0.07503550499677658,
-0.05343309044837952,
0.21862667798995972,
0.08898419886827469,
-0.016729138791561127,
-0.07322366535663605,
-0.12517166137695312,
0.1364119052886963,
-0.04911278188228607,
0.19037629663944244,
-0.023426605388522148,
0.08817083388566971,
-0.15980133414268494,
-0.03963242843747139,
0.30156898498535156,
-0.0715303048491478,
-0.034140728414058685,
-0.08240588009357452,
-0.1002354621887207,
-0.005054857581853867,
-0.0005247805966064334,
0.06725762784481049,
-0.07635095715522766,
-0.01049746572971344,
-0.11580405384302139,
0.06326740980148315,
0.2708716094493866,
-0.001574573339894414,
-0.04342133551836014,
-0.10448071360588074,
-0.09675515443086624,
-0.008151163347065449,
0.06337712705135345,
0.03305575251579285,
0.15282686054706573,
-0.033616114407777786,
0.2197318822145462,
0.04802361875772476,
0.2568926513195038,
-0.08094862103462219,
-0.01473658625036478,
0.16205167770385742,
-0.08512907475233078,
-0.06672869622707367,
-0.11415313184261322,
-0.11203168332576752,
-0.271054208278656,
-0.10079546272754669,
0.0886140838265419,
-0.0969110056757927,
0.20372532308101654,
0.053346339613199234,
0.13612914085388184,
0.17666201293468475,
0.026145728304982185,
0.00472941342741251,
0.24895338714122772,
-0.1486680656671524,
-0.08829669654369354,
-0.03884346783161163,
0.08727438002824783,
-0.08776532113552094,
0.3881974518299103,
-0.11802173405885696,
-0.09250902384519577,
-0.052152492105960846,
-0.09576986730098724,
0.04918908327817917,
-0.13666895031929016,
0.058660540729761124,
0.21439138054847717,
-0.09457563608884811,
0.1636793166399002,
-0.12309815734624863,
0.2668987214565277,
0.05658264458179474,
0.02359907142817974,
0.11215327680110931,
0.061932407319545746,
0.08112777769565582,
-0.08784104883670807,
-0.011875159107148647,
0.014180402271449566,
-0.08123647421598434,
0.04316001757979393,
-0.009019237011671066,
-0.03203275427222252,
0.00760096637532115,
-0.0177405197173357,
-0.22535383701324463,
-0.006699713412672281,
-0.07869625836610794,
-0.04231182485818863,
-0.0714171901345253,
-0.10072646290063858,
-0.13453994691371918,
0.07212723791599274,
0.25005432963371277,
-0.07269902527332306,
0.38527852296829224,
0.19246608018875122,
0.07695522904396057,
-0.03714525327086449,
-0.15038859844207764,
0.10783327370882034,
-0.28330567479133606,
0.17992763221263885,
0.10990533232688904,
-0.043158158659935,
-0.07311483472585678,
0.17171595990657806,
0.014135516248643398,
-0.058731503784656525,
0.04902974143624306,
-0.13787251710891724,
-0.02625027671456337,
0.02247992344200611,
0.15936951339244843,
-0.1989213079214096,
0.3439980447292328,
0.005595609545707703,
-0.04399918019771576,
-0.038710106164216995,
0.21845325827598572,
-0.02029491402208805,
-0.12094118446111679,
0.03165631741285324,
-0.10370450466871262,
-0.0011947613675147295,
0.09717618674039841,
0.0033105998300015926,
0.013154653832316399,
-0.05427103489637375,
-0.1192760318517685,
0.13511911034584045,
0.018367217853665352,
-0.0928451269865036,
-0.012332082726061344,
-0.06791646778583527,
0.011676582507789135,
0.0005352181033231318,
0.012063777074217796,
0.06494909524917603,
0.1179431825876236,
-0.2531185448169708,
0.013231691904366016,
0.14913411438465118,
0.1653110235929489,
0.05437753349542618,
0.07913528382778168,
-0.20487657189369202,
-0.03302142396569252,
0.04409101977944374,
0.060948703438043594,
-0.08507363498210907,
0.06480766087770462,
-0.034628767520189285,
-0.03154303878545761,
-0.033965617418289185,
0.09382855892181396,
-0.05292578414082527,
0.006581599824130535,
-0.0048911478370428085,
-0.07433180510997772,
-0.4871205687522888,
0.009209716692566872,
0.04304047301411629,
0.010210315696895123,
0.02535095065832138,
0.05187945067882538,
0.03688494861125946,
0.2277480959892273,
0.005479244515299797,
-0.04195690155029297,
-0.02704448439180851,
0.010412478819489479,
-0.1701529175043106,
-0.10041943937540054,
0.007742713205516338,
-0.2977800965309143,
-0.19247540831565857,
0.04959098622202873,
0.040328823029994965,
0.08316635340452194,
-0.0775337889790535,
0.006083832588046789,
-0.03306567668914795,
-0.13567189872264862,
0.09680816531181335,
-0.06405496597290039,
-0.02328350581228733,
-0.0394858755171299,
-0.20800849795341492,
-0.020422587171196938,
0.0203718114644289,
-0.08171290159225464,
0.08657204359769821,
0.13627979159355164,
0.04583221673965454,
0.15884585678577423,
0.04513644799590111,
0.14883741736412048,
-0.09631664305925369,
-0.10802188515663147,
-0.027863027527928352,
-0.006698200944811106,
-0.06845028698444366,
0.011811957694590092,
0.11499694734811783,
-0.01915837824344635,
0.058940768241882324,
-0.22712568938732147,
-0.015595803037285805,
-0.10754083842039108,
-0.09753239899873734,
0.046901870518922806,
-0.15178528428077698,
0.18548153340816498,
-0.20743682980537415,
0.13976944983005524,
-0.1936882734298706,
0.05865917354822159,
-0.1344023197889328,
-0.09572438150644302,
-0.01600932888686657,
0.03192656487226486,
-0.07891694456338882,
0.10614681988954544,
0.0329313799738884,
0.17792464792728424,
0.20975002646446228,
-0.06897518038749695,
0.24824872612953186,
0.24226275086402893,
-0.05085083097219467,
-0.02961716055870056,
-0.17230156064033508,
0.05517043173313141,
-0.014410979114472866,
-0.052416328340768814,
-0.08457191288471222,
-0.07216259092092514,
0.02161291427910328,
-0.10663796961307526,
-0.09422781318426132,
0.14564894139766693,
0.25039607286453247,
-0.041891101747751236,
-0.1159774661064148,
-0.03841347247362137,
0.12528784573078156,
-0.16365157067775726,
-0.13939422369003296,
0.10106409341096878,
-0.028415003791451454,
-0.07778353244066238,
0.05484273284673691,
-0.11969675868749619,
0.16490685939788818,
-0.1412021368741989,
-0.06867282837629318,
-0.052766118198633194,
-0.007575657684355974,
-0.09829086810350418,
0.18041469156742096,
0.23926019668579102,
0.07801444083452225,
-0.07320551574230194,
0.07530795782804489,
-0.10494396090507507,
0.018116740509867668,
0.0630393773317337,
0.16434790194034576,
-0.012167149223387241,
0.011162260547280312,
0.05752262473106384,
-0.020318150520324707,
0.10377885401248932,
0.043380286544561386,
0.13229206204414368,
0.029283083975315094,
0.14405390620231628,
0.16676917672157288,
0.044424720108509064,
-0.029081283137202263,
-0.015144018456339836,
-0.2441234588623047,
0.1360412985086441,
0.11902676522731781,
0.05377766117453575,
0.04395751655101776,
0.10132385790348053,
0.13672225177288055,
0.06947008520364761,
-0.0070859710685908794,
0.19433307647705078,
-0.16038425266742706,
0.034598447382450104,
0.0909402146935463,
-0.22288928925991058,
0.015284990891814232,
0.2161930799484253,
0.09610695391893387,
-0.05523858219385147,
-0.17008928954601288,
0.12280179560184479,
-0.14961466193199158,
-0.087241530418396,
-0.0795007273554802,
0.18403373658657074,
-0.09818167984485626,
-0.11637116223573685,
0.04835515096783638,
0.15926110744476318,
-0.050096917897462845,
0.05716932192444801,
0.013581878505647182,
0.14247548580169678,
0.1256132572889328,
-0.016739245504140854,
0.10256210714578629,
0.13817884027957916,
-0.13864952325820923,
-0.06437106430530548,
-0.189968541264534,
-0.07232847809791565,
0.02806089073419571,
0.12009754776954651,
0.18154330551624298,
0.0852084681391716,
-0.2094503939151764,
0.07813088595867157,
0.1947382539510727,
0.05138678103685379,
0.04864247143268585,
-0.17018747329711914,
-0.014786754734814167,
0.05286361649632454,
0.14974115788936615,
0.1190013736486435,
0.19386686384677887,
0.181541308760643,
-0.1957729607820511,
-0.008467057719826698,
0.015425481833517551,
-0.023927420377731323,
0.19198541343212128,
-0.057572346180677414,
0.4034521281719208,
-0.02244661934673786,
0.24293909966945648,
0.15727218985557556,
-0.36699268221855164,
-0.057252753525972366,
0.009462769143283367,
0.09247195720672607,
0.023341476917266846,
0.05942415073513985,
-0.11363900452852249,
0.07589653879404068,
0.027605880051851273,
-0.09708048403263092,
-0.010277954861521721,
-0.13826461136341095,
-0.0264272540807724,
0.06949272751808167,
-0.03322721645236015,
0.012789889238774776,
-0.1463501751422882,
-0.15051056444644928,
-0.041404739022254944,
0.10104826092720032,
0.09522169083356857,
-0.07467224448919296,
0.07529205083847046,
-0.07221032679080963,
-0.0010040461784228683,
-0.05235743522644043,
0.17751407623291016,
0.031242502853274345,
0.10964897274971008,
0.002373381517827511,
-0.10773909091949463,
-0.10637576133012772,
-0.10000667721033096,
-0.06484729051589966,
0.02676648460328579,
-0.0464731827378273,
-0.025405006483197212,
0.09028299152851105,
-0.1527535766363144,
0.21748384833335876,
-0.19373974204063416,
-0.09500294178724289,
-0.06218952685594559,
0.06782539933919907,
0.09060391783714294,
0.013724662363529205,
-0.11803069710731506,
-0.014133680611848831,
-0.006273935548961163,
0.045104894787073135,
0.0787261426448822,
0.05489669367671013,
-0.030834589153528214,
-0.24688535928726196,
-0.20106416940689087,
-0.019871531054377556,
0.0015285714762285352,
-0.13023510575294495,
-0.02046644315123558,
0.020517027005553246,
0.02548208460211754,
0.09884555637836456,
0.07770610600709915,
-0.1630091816186905,
0.04925423488020897,
-0.22519466280937195,
0.08109331876039505,
0.22083842754364014,
0.011220177635550499,
-0.08736954629421234,
-0.11681955307722092,
-0.08729303628206253,
-0.07706510275602341,
-0.3011597692966461,
0.07558667659759521,
-0.09611500799655914,
0.13205431401729584,
-0.10237587243318558,
0.11231403797864914,
-0.21265089511871338,
0.01911672204732895,
-0.011598275974392891,
-0.03597476705908775,
-0.29926303029060364,
-0.057261884212493896,
0.15638203918933868,
-0.032358720898628235,
-0.1815377026796341,
-0.11543315649032593,
-0.0492827333509922,
-0.16661454737186432,
0.050680212676525116,
-0.04287261143326759,
0.08342716842889786,
0.08404170721769333,
-0.09888282418251038,
-0.18004365265369415,
-0.07906674593687057,
-0.022307921200990677,
0.0457204133272171,
0.02938462793827057,
0.04931161180138588,
-0.051804669201374054,
0.004241774324327707,
0.0464366190135479,
-0.1160857081413269,
0.14879755675792694,
-0.03650815039873123,
0.020199639722704887,
-0.003362840972840786,
-0.07663550227880478,
-0.0017497210064902902,
-0.19726550579071045,
0.06527499109506607,
0.051200900226831436,
-0.026650210842490196,
0.052510205656290054,
0.10812635719776154,
-0.1720438152551651,
0.006656993180513382,
-0.10169649124145508,
-0.09041213244199753,
-0.03647925704717636,
0.35813164710998535,
0.000791626051068306,
0.05275552347302437,
0.07014822214841843,
-0.006416386924684048,
-0.20996712148189545,
-0.021768048405647278,
0.05978723242878914,
0.06388344615697861,
-0.15043647587299347,
0.038544364273548126,
-0.25392279028892517,
-0.20655876398086548,
-0.28213682770729065,
0.07791462540626526,
-0.0362563319504261,
-0.2987578511238098,
0.0478239580988884,
0.06627089530229568,
0.15374146401882172,
0.18037056922912598,
-0.04097145050764084,
0.060262005776166916,
0.014714663848280907,
-0.11512129753828049,
0.16850517690181732,
-0.1841871440410614,
-0.029232211410999298,
-0.11322059482336044,
-0.045386817306280136,
0.08098616451025009,
0.050797294825315475,
0.11075231432914734,
-0.018559617921710014,
-0.08084418624639511,
-0.18033237755298615,
0.13212819397449493,
0.007379704155027866,
-0.22513753175735474,
0.0036858306266367435,
0.01969149336218834,
0.11069702357053757,
-0.313834011554718,
0.24242356419563293,
-0.08880025893449783,
-0.03047202341258526,
-0.11313934624195099,
-0.06148538365960121,
-0.082692451775074,
0.3365817964076996,
-0.05543304234743118,
0.03490767627954483,
-0.0804208368062973,
0.1027752086520195,
-0.0882398933172226,
0.25919678807258606,
0.013437897898256779,
0.21388211846351624,
-0.2105405479669571,
-0.13625603914260864,
0.1798579841852188,
0.03508105129003525,
0.0030526225455105305,
-0.05267518013715744,
-0.05450593680143356,
-0.004713088274002075,
-0.06834106147289276,
-0.13720551133155823,
0.1424446552991867,
-0.06918695569038391,
0.00958260614424944,
-0.06801497936248779,
0.12705864012241364,
0.1189083531498909,
-0.16483023762702942,
0.01704385317862034,
-0.05159013718366623,
0.03972217068076134,
0.17160795629024506,
-0.08444169163703918,
0.15967586636543274,
-0.20847122371196747,
-0.08184482157230377,
0.08454826474189758,
-0.00024816577206365764,
0.10436660796403885,
0.1781216263771057,
-0.2659197747707367,
0.09898778796195984,
-0.037626106292009354,
-0.18290814757347107,
-0.06146611273288727,
-0.03276785463094711,
0.09877429902553558,
-0.2382921725511551,
0.03616596385836601,
-0.15765579044818878,
-0.20797955989837646,
0.044797804206609726,
0.15972307324409485,
0.059050820767879486,
0.11432937532663345,
-0.0926288366317749,
0.06790032982826233,
-0.23707543313503265,
0.17397810518741608,
0.006334942765533924,
0.017714889720082283,
0.08188444375991821,
0.023248234763741493,
0.030657295137643814,
-0.07275832444429398,
0.02195112779736519,
-0.022399477660655975,
0.229360893368721,
-0.14166632294654846,
-0.2739626169204712,
-0.01225706934928894,
-0.05137095972895622,
0.00946444645524025,
0.13154056668281555,
0.04435093328356743,
0.08221665024757385,
0.16381698846817017,
-0.04738811030983925,
0.007228285074234009,
-0.011362743563950062,
0.09793981909751892,
0.08754947036504745,
-0.11369075626134872,
-0.06525588035583496,
0.30724984407424927,
0.13546818494796753,
0.0004407161904964596,
-0.07456675171852112,
0.12477946281433105,
-0.056109219789505005,
0.1114095076918602,
0.00028514329460449517,
0.0013446795055642724,
-0.0010916470782831311,
0.17154312133789062,
-0.1521025449037552,
-0.11891969293355942,
-0.28222331404685974,
-0.019707579165697098,
-0.07542198151350021,
0.1534215658903122,
0.1792573481798172,
-0.01147978100925684,
0.07930067181587219,
0.05591201037168503,
-0.12803833186626434,
-0.04416965693235397,
-0.020780887454748154,
-0.08112335950136185,
0.05243320018053055,
-0.08217591792345047,
-0.26706111431121826,
0.12572811543941498,
0.0703577920794487,
-0.29994216561317444,
0.33250758051872253,
0.111273393034935,
-0.06969571858644485,
-0.10274746268987656,
0.0035541013348847628,
-0.2424601912498474,
0.15093493461608887,
0.08592751622200012,
-0.011289805173873901,
-0.05789828300476074,
-0.003750096308067441,
0.023337870836257935,
0.024253563955426216,
0.0695413127541542,
-0.0672161802649498,
-0.025651639327406883,
-0.0867268294095993,
0.07162762433290482,
0.013159417547285557,
-0.04430592432618141,
-0.16116711497306824,
-0.05488608777523041,
-0.005961067974567413,
0.1479020118713379,
0.28496935963630676,
0.04362882673740387,
0.08352186530828476,
-0.1065310686826706,
0.1498948037624359,
-0.06319606304168701,
-0.1125214621424675,
-0.036398742347955704,
0.04170253127813339,
-0.11667776852846146,
-0.06432054936885834,
-0.03436335176229477,
0.012757034040987492,
0.13560032844543457,
0.014468654990196228,
-0.1739291399717331,
-0.10976234823465347
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. 4. Lupi et al 5. Gene-targeted deletion/duplication analysis detects intragenic deletions or duplications. Methods used may include: quantitative PCR, long-range PCR, multiplex ligation-dependent probe amplification (MLPA), and gene-targeted microarray designed to detect single-exon deletions or duplications.6. Amish from Geauga County, Ohio 7. Druze and Arab Muslims from northern Israel Measurement of prolidase enzyme activity. In affected individuals, prolidase enzyme activity in erythrocytes, leukocytes, or cultured fibroblasts ranges from none to <10% .Click here (pdf) for a short review of laboratory techniques used in the diagnosis of prolidase deficiency; see also Kurien et al and Viglio et al .Clinical CharacteristicsClinical DescriptionSkin. The hallmark of prolidase deficiency is severe, chronic, recalcitrant, and painful skin ulcers. The ulcers are located mainly on the lower extremities, particularly the feet. However | [
-0.21406786143779755,
0.14177542924880981,
0.027147682383656502,
-0.30532604455947876,
0.10846281796693802,
0.09126541018486023,
0.06369157880544662,
-0.025443553924560547,
-0.08471208065748215,
-0.17867936193943024,
0.0827852189540863,
0.13890241086483002,
0.339537113904953,
-0.056987371295690536,
-0.26506224274635315,
0.14379358291625977,
0.12796129286289215,
-0.14094111323356628,
-0.10585420578718185,
0.06586581468582153,
0.06712555140256882,
-0.0698222741484642,
0.2782544493675232,
0.15456776320934296,
0.2438115030527115,
-0.023044269531965256,
-0.020748509094119072,
0.1534426361322403,
-0.1281103491783142,
0.08815955370664597,
0.02316989190876484,
-0.06026102975010872,
-0.0014722724445164204,
-0.29657870531082153,
0.14965951442718506,
0.007498812396079302,
-0.0751698762178421,
0.09297487884759903,
0.23581257462501526,
0.05432811379432678,
-0.1086365133523941,
-0.002066381275653839,
0.06425033509731293,
-0.04394524544477463,
-0.024964965879917145,
-0.06829695403575897,
-0.019984284415841103,
0.15432313084602356,
-0.04921191558241844,
0.02759610302746296,
0.1667500138282776,
-0.05287741869688034,
-0.03272193297743797,
0.008274633437395096,
0.1316203624010086,
0.14014188945293427,
-0.08122518658638,
0.011300726793706417,
-0.17342722415924072,
0.05441461130976677,
0.031264252960681915,
0.019781991839408875,
0.030824048444628716,
-0.2114173322916031,
0.2478981912136078,
0.021697448566555977,
0.02686832845211029,
-0.17985886335372925,
-0.07352793216705322,
0.055423300713300705,
0.45915475487709045,
-0.0007446712697856128,
0.23059867322444916,
0.06368841230869293,
-0.11223156750202179,
-0.11193875968456268,
0.07851683348417282,
-0.08742393553256989,
0.13382677733898163,
-0.22428108751773834,
-0.10512221604585648,
0.0766209289431572,
-0.07262527942657471,
0.07806909829378128,
0.02949874848127365,
0.219981387257576,
0.13589352369308472,
-0.06194411218166351,
0.0647130012512207,
0.09087004512548447,
0.033970609307289124,
-0.1729818880558014,
0.07015283405780792,
-0.05659475922584534,
-0.05174156650900841,
-0.18710294365882874,
-0.06044742092490196,
-0.14604774117469788,
-0.036837924271821976,
0.10202155262231827,
0.17065127193927765,
0.1595456749200821,
0.03306734934449196,
0.0941658541560173,
0.15776021778583527,
-0.042425259947776794,
-0.07635708898305893,
-0.014123447239398956,
-0.13521483540534973,
0.24430379271507263,
0.09848863631486893,
0.06928955763578415,
-0.12598557770252228,
-0.06047820672392845,
-0.00851812120527029,
0.16328099370002747,
0.24141325056552887,
0.0161688644438982,
-0.13290734589099884,
-0.16706489026546478,
-0.13960163295269012,
-0.022099414840340614,
0.04077156260609627,
-0.09736520051956177,
0.2594248652458191,
0.09850098937749863,
0.03072451986372471,
0.08596368879079819,
0.19449658691883087,
-0.2233116179704666,
0.05480466037988663,
-0.1553400307893753,
-0.11807408183813095,
-0.21648728847503662,
-0.15829022228717804,
-0.06362292915582657,
-0.200351282954216,
-0.038919877260923386,
-0.000054419437219621614,
-0.1266624480485916,
-0.08475810289382935,
-0.09580869972705841,
0.2707579433917999,
0.33237916231155396,
-0.10673429071903229,
0.23925398290157318,
0.40167880058288574,
-0.00821894221007824,
0.07274194806814194,
-0.1219286397099495,
0.12190575152635574,
-0.07397633045911789,
0.4528941214084625,
-0.094436414539814,
-0.010286638513207436,
0.11527694016695023,
-0.2206135243177414,
0.041860174387693405,
-0.14774559438228607,
-0.047567084431648254,
0.23802554607391357,
-0.15275391936302185,
0.12293308973312378,
-0.12923671305179596,
-0.012484914623200893,
-0.08492077887058258,
-0.04637959226965904,
-0.08040138334035873,
0.08574707806110382,
0.18465928733348846,
-0.06607135385274887,
0.09779734909534454,
-0.036166273057460785,
0.11977899819612503,
0.1417320966720581,
-0.06371009349822998,
-0.13192251324653625,
-0.10861465334892273,
0.024478551000356674,
-0.06554142385721207,
-0.03411426767706871,
0.015473155304789543,
-0.024544354528188705,
-0.021540381014347076,
-0.0683320090174675,
-0.20489563047885895,
0.04149819537997246,
0.24866540729999542,
0.1403231918811798,
0.20212212204933167,
0.1507476419210434,
0.042368896305561066,
0.033291466534137726,
-0.16173791885375977,
0.07644367963075638,
-0.11137385666370392,
-0.030296167358756065,
0.06579183787107468,
-0.10153213888406754,
-0.07741784304380417,
0.17866995930671692,
-0.14409027993679047,
0.1831917017698288,
-0.041089437901973724,
-0.03405923768877983,
0.09726369380950928,
-0.08624517172574997,
0.012645374983549118,
-0.18178732693195343,
0.2721046209335327,
0.071366086602211,
0.12856461107730865,
-0.013775232248008251,
0.15584944188594818,
-0.05075117573142052,
0.02273477613925934,
-0.1153775155544281,
0.03454374521970749,
-0.06343329697847366,
0.08423061668872833,
0.03754261136054993,
0.0393231026828289,
-0.004938649479299784,
-0.2427445948123932,
0.08273562043905258,
0.13776110112667084,
-0.018886517733335495,
0.02199537865817547,
-0.005902450531721115,
0.05437104403972626,
0.02498003840446472,
0.10528300702571869,
0.14184260368347168,
0.15428858995437622,
-0.12262327969074249,
-0.11347199231386185,
0.08447550982236862,
0.25199997425079346,
0.08512040972709656,
0.17766821384429932,
-0.14560125768184662,
-0.09416481852531433,
0.11273980140686035,
-0.06076783686876297,
-0.06864304095506668,
0.1099960133433342,
-0.034448519349098206,
0.124531090259552,
0.01786213368177414,
0.11486238986253738,
-0.017837636172771454,
-0.027134623378515244,
0.11103123426437378,
-0.13807862997055054,
-0.45676422119140625,
-0.050640761852264404,
0.10642986744642258,
-0.05910918116569519,
0.07638903707265854,
0.1285538524389267,
0.08146624267101288,
0.07414136081933975,
0.14914105832576752,
-0.02114151231944561,
0.05991171672940254,
0.11458447575569153,
-0.1368151754140854,
0.1782180815935135,
0.006630028132349253,
-0.3207477629184723,
-0.01647351309657097,
0.04118216037750244,
0.19444943964481354,
0.2838812470436096,
-0.08110304176807404,
0.06746239960193634,
-0.2626402974128723,
0.14230118691921234,
0.24305325746536255,
-0.1959267258644104,
-0.02441774681210518,
-0.10524781048297882,
-0.2103613168001175,
-0.06584835052490234,
0.20273937284946442,
0.13236692547798157,
0.07532500475645065,
0.1885305643081665,
-0.012437064200639725,
0.10328193008899689,
-0.055087510496377945,
0.12301846593618393,
-0.18308936059474945,
0.04130406305193901,
0.16048415005207062,
-0.0027332825120538473,
-0.170516699552536,
-0.038793180137872696,
0.24127231538295746,
-0.007419778034090996,
0.02968565933406353,
0.11337035894393921,
-0.01953941397368908,
-0.029973473399877548,
-0.077828548848629,
-0.0737626701593399,
0.04431135579943657,
0.12553711235523224,
-0.21383345127105713,
0.022346850484609604,
-0.08198961615562439,
0.034349191933870316,
-0.1868741810321808,
-0.34508058428764343,
-0.09127673506736755,
0.0104020731523633,
-0.2281152456998825,
0.14922969043254852,
0.24578312039375305,
0.1469399631023407,
0.2649969458580017,
0.000582852226216346,
0.10110544413328171,
0.26342645287513733,
0.05403732508420944,
-0.09866420179605484,
-0.13809247314929962,
-0.1250537782907486,
-0.03450508415699005,
-0.2570599317550659,
0.03333817049860954,
0.04975096881389618,
0.11307284981012344,
-0.03835126385092735,
0.05402760207653046,
0.027651963755488396,
0.23109780251979828,
-0.25939586758613586,
-0.06463980674743652,
0.1360180675983429,
0.04457838460803032,
-0.22434532642364502,
-0.07081381231546402,
-0.13855807483196259,
-0.09045445919036865,
-0.050223447382450104,
0.18063510954380035,
-0.042857825756073,
0.1443168669939041,
-0.09077003598213196,
-0.06438875943422318,
-0.04701361805200577,
-0.09225810319185257,
-0.14148427546024323,
0.16596069931983948,
0.31349503993988037,
-0.0006467007333412766,
-0.06352166086435318,
0.14310471713542938,
-0.12256543338298798,
-0.10696908086538315,
0.1721920520067215,
0.4024944305419922,
-0.23834525048732758,
0.23857949674129486,
0.04853840172290802,
0.1329922378063202,
0.04569200426340103,
-0.005226657260209322,
-0.012036439962685108,
-0.020363150164484978,
-0.03713594749569893,
0.16117100417613983,
0.11822383850812912,
0.029086459428071976,
0.07919752597808838,
-0.27622929215431213,
0.2335716336965561,
0.05149093270301819,
-0.05968412011861801,
0.0790405422449112,
0.11208982765674591,
0.17915265262126923,
0.14243976771831512,
-0.06749582290649414,
0.2501278817653656,
-0.1549322009086609,
0.1194298267364502,
0.052462730556726456,
-0.07362214475870132,
0.2922973930835724,
0.2217281460762024,
-0.07336705178022385,
-0.014233648777008057,
-0.24995248019695282,
0.10167378932237625,
0.016038306057453156,
-0.030027074739336967,
-0.10582861304283142,
0.13814006745815277,
-0.018800213932991028,
-0.038585737347602844,
0.06952925026416779,
0.1741628348827362,
0.1387992948293686,
0.14810810983181,
0.14572259783744812,
0.12263786047697067,
0.15754839777946472,
-0.0477232001721859,
0.0862671434879303,
0.016466328874230385,
-0.06677320599555969,
-0.10149416327476501,
0.0018846868770197034,
-0.14740490913391113,
-0.04273354634642601,
0.1844961792230606,
0.20036622881889343,
-0.07832682132720947,
-0.2608143389225006,
-0.13284353911876678,
0.31377750635147095,
0.006883541122078896,
-0.02516149915754795,
-0.0884043276309967,
-0.01670769788324833,
-0.08631394803524017,
0.062149327248334885,
0.1819561868906021,
0.14792566001415253,
0.057406313717365265,
-0.11844794452190399,
-0.027795808389782906,
0.16486254334449768,
0.012154323048889637,
0.16182968020439148,
0.037608977407217026,
0.2654467523097992,
0.08881431072950363,
0.19886960089206696,
0.07095737755298615,
-0.20194999873638153,
-0.2318941354751587,
-0.1296473741531372,
0.216950923204422,
0.0681489035487175,
0.029200274497270584,
0.21942360699176788,
0.07704797387123108,
0.05204697325825691,
-0.13799312710762024,
0.0960066020488739,
-0.014910317957401276,
-0.13051390647888184,
0.05589601770043373,
-0.10732171684503555,
-0.20225177705287933,
-0.11616439372301102,
0.026007959619164467,
0.07804529368877411,
0.1750916987657547,
-0.08617667108774185,
-0.25162509083747864,
-0.05151616781949997,
0.09467928856611252,
-0.08185060322284698,
0.10700375586748123,
0.09861798584461212,
0.025860758498311043,
0.10824193060398102,
0.10004488378763199,
-0.019372139126062393,
-0.02042042836546898,
-0.18609614670276642,
0.10285927355289459,
-0.03740649297833443,
-0.001335256383754313,
-0.09285017848014832,
0.007492430508136749,
-0.15327021479606628,
0.09523472189903259,
-0.23935724794864655,
0.06069713458418846,
0.014669453725218773,
-0.0846937820315361,
0.06736434251070023,
-0.057815827429294586,
0.11479819566011429,
-0.09963410347700119,
-0.10789943486452103,
0.07018697261810303,
-0.008264381438493729,
0.2640998959541321,
0.22383354604244232,
0.052743807435035706,
-0.1778164803981781,
-0.14844264090061188,
0.012627022340893745,
-0.11882564425468445,
0.07237912714481354,
-0.11285801976919174,
0.10932889580726624,
0.3137741684913635,
0.09584885090589523,
-0.1557190865278244,
-0.029791289940476418,
-0.2565174996852875,
0.08585711568593979,
0.24397693574428558,
0.11130400747060776,
-0.13993556797504425,
-0.17215386033058167,
-0.10336606949567795,
-0.0343099907040596,
-0.18462423980236053,
0.13133548200130463,
0.014450413174927235,
0.1363714337348938,
0.0949413850903511,
0.0009372822823934257,
-0.2091151773929596,
0.09055627882480621,
0.11825653165578842,
0.0027944245375692844,
-0.2940537929534912,
-0.04917595162987709,
0.06831476837396622,
-0.11933085322380066,
-0.20892910659313202,
-0.23948585987091064,
-0.0017116505187004805,
-0.07231877744197845,
0.03261099010705948,
-0.009293369948863983,
-0.08590547740459442,
-0.18179354071617126,
-0.02326512150466442,
-0.024343054741621017,
-0.1327327936887741,
-0.021534385159611702,
0.1409406065940857,
-0.080788254737854,
0.004649174865335226,
-0.08797016739845276,
0.08132348209619522,
-0.04708743467926979,
-0.11404377222061157,
-0.1733264923095703,
0.042137306183576584,
-0.07745303958654404,
0.1582408994436264,
0.03696604445576668,
0.1578357070684433,
-0.12384824454784393,
-0.026346787810325623,
0.1042633205652237,
-0.002127294894307852,
-0.1825849860906601,
0.010088239796459675,
-0.07548493146896362,
0.011717572808265686,
-0.1878691166639328,
-0.05710100755095482,
-0.11434463411569595,
0.19768092036247253,
0.06405746936798096,
0.020735589787364006,
-0.13673843443393707,
-0.09356776624917984,
-0.1673877239227295,
0.0323953703045845,
-0.003925074823200703,
-0.17849095165729523,
-0.29440271854400635,
-0.07946083694696426,
-0.17981202900409698,
-0.13023918867111206,
-0.14254048466682434,
0.23702646791934967,
-0.04904524236917496,
-0.18014675378799438,
-0.020795466378331184,
0.09672518819570541,
-0.0182382483035326,
0.10942844301462173,
0.01825147680938244,
0.029136288911104202,
-0.004437061492353678,
-0.09368784725666046,
0.18407899141311646,
-0.20137260854244232,
-0.08919306099414825,
-0.118931345641613,
0.11900708824396133,
0.1239083781838417,
-0.0637381300330162,
-0.1961735039949417,
0.13764911890029907,
-0.06014174222946167,
-0.11531422287225723,
0.17399857938289642,
0.021975841373205185,
-0.14513614773750305,
-0.046146210283041,
0.1668505072593689,
0.05970701575279236,
-0.34241876006126404,
0.0895022377371788,
-0.0016514399321749806,
0.14089840650558472,
-0.10984568297863007,
0.15885302424430847,
-0.09458883106708527,
0.30741435289382935,
0.07038763165473938,
0.041498757898807526,
-0.1930360645055771,
-0.014264320023357868,
-0.22337593138217926,
0.12025989592075348,
-0.01001095212996006,
0.0886211022734642,
-0.28686413168907166,
-0.1420591175556183,
0.014209534041583538,
0.11828099191188812,
0.08376821875572205,
-0.04642230644822121,
0.1617286503314972,
0.03226161003112793,
-0.018909180536866188,
-0.06976163387298584,
0.1574641466140747,
-0.030377687886357307,
0.24821478128433228,
-0.026962628588080406,
0.25666627287864685,
0.006354671437293291,
0.0914863646030426,
-0.03037363477051258,
0.06963328272104263,
-0.07920049875974655,
0.11180340498685837,
-0.07960746437311172,
0.2770693004131317,
-0.08498834073543549,
-0.06947258114814758,
0.1590752899646759,
-0.13263626396656036,
0.07776124775409698,
0.03737843036651611,
-0.14896202087402344,
0.03714594617486,
-0.011885148473083973,
-0.11172551661729813,
0.16777342557907104,
0.006532695144414902,
0.05114666372537613,
-0.19015641510486603,
0.053581323474645615,
-0.18515680730342865,
-0.12149660289287567,
0.08517363667488098,
0.0848948284983635,
0.09019175916910172,
0.11931807547807693,
-0.05610908940434456,
-0.017865654081106186,
-0.19029517471790314,
0.16659651696681976,
0.08383384346961975,
-0.08027409762144089,
0.1426916867494583,
-0.0009353823261335492,
0.03029557690024376,
-0.18136180937290192,
-0.1639617383480072,
-0.084034763276577,
0.08984841406345367,
-0.09928236156702042,
-0.2583135962486267,
-0.16868779063224792,
-0.07550612092018127,
0.04905594512820244,
0.11467592418193817,
-0.03702010214328766,
0.1325342208147049,
0.2759827673435211,
-0.03986596688628197,
-0.061749737709760666,
-0.0876813605427742,
0.23062767088413239,
0.08714573830366135,
-0.058331165462732315,
-0.21276463568210602,
0.0927022323012352,
0.2011699229478836,
0.07756586372852325,
-0.06669516116380692,
0.0639616921544075,
-0.10088732838630676,
-0.07778792083263397,
0.0680132582783699,
0.03828613460063934,
0.04789166525006294,
0.2505266070365906,
-0.23848043382167816,
-0.12094329297542572,
0.026212969794869423,
0.02614380419254303,
-0.12811243534088135,
-0.06756275147199631,
0.1313672810792923,
0.02622048370540142,
-0.013317903503775597,
-0.19749662280082703,
-0.18338844180107117,
-0.05023351311683655,
0.11811477690935135,
0.0331464558839798,
0.05139203369617462,
0.040331121534109116,
-0.12480500340461731,
0.06118553504347801,
-0.0528990738093853,
-0.16162914037704468,
0.0831146314740181,
0.2884750962257385,
-0.11793088912963867,
-0.1485103815793991,
-0.12246093153953552,
-0.1851923018693924,
0.20084087550640106,
-0.009135361760854721,
-0.027612265199422836,
0.1474783569574356,
-0.03261389583349228,
-0.13350379467010498,
0.07544925063848495,
0.1411498337984085,
0.03466438502073288,
0.03871222585439682,
-0.028234515339136124,
0.16438370943069458,
0.0740741714835167,
-0.2363966703414917,
-0.13089005649089813,
-0.05604323744773865,
-0.011039924807846546,
0.20740747451782227,
0.0013173787156119943,
-0.00988063681870699,
0.14715059101581573,
0.04270569235086441,
-0.041748952120542526,
-0.1524670422077179,
-0.29978147149086,
0.0361853763461113,
0.006254245992749929,
-0.18685762584209442,
-0.025221997871994972,
-0.05843660980463028,
-0.03412415087223053,
-0.024991068989038467,
-0.04030095413327217,
-0.15360872447490692,
0.12023326009511948
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. affected individuals, prolidase enzyme activity in erythrocytes, leukocytes, or cultured fibroblasts ranges from none to <10% .Click here (pdf) for a short review of laboratory techniques used in the diagnosis of prolidase deficiency; see also Kurien et al and Viglio et al .Clinical CharacteristicsClinical DescriptionSkin. The hallmark of prolidase deficiency is severe, chronic, recalcitrant, and painful skin ulcers. The ulcers are located mainly on the lower extremities, particularly the feet. However, individuals are reported with upper extremity involvement, including one with recurrent upper extremity ulceration beginning at age nine years , one with active ulcers on the hands , and one with a healed scar from prior ulcers in the dorsum of the hand . One had scarring from healed ulcers over most of her body; however, at the time of publication active ulcers were mainly on the legs .Skin ulcers can begin as early as age six months or as late as age 30 years .Ulceration is | [
-0.10198824852705002,
0.12400460988283157,
0.012406024150550365,
-0.2912937104701996,
0.03426799550652504,
0.1448885202407837,
-0.009029448963701725,
-0.05223134532570839,
-0.13810251653194427,
-0.20188581943511963,
0.13445945084095,
0.17934530973434448,
0.2681020200252533,
0.04105391725897789,
-0.21386383473873138,
0.15410105884075165,
0.10924764722585678,
-0.13159815967082977,
-0.081216961145401,
-0.008200920186936855,
0.027241576462984085,
-0.13256798684597015,
0.24845267832279205,
0.14969341456890106,
0.2975357472896576,
-0.08556805551052094,
0.03133997693657875,
0.11250917613506317,
-0.11823476850986481,
0.1264432966709137,
-0.034887757152318954,
-0.06828669458627701,
-0.03978133574128151,
-0.26627346873283386,
0.18503345549106598,
0.025399526581168175,
-0.06208786368370056,
0.1312849223613739,
0.1601581573486328,
0.08398415148258209,
-0.20020385086536407,
-0.038636237382888794,
0.04422006756067276,
0.007636527996510267,
-0.0981682762503624,
-0.03504261001944542,
-0.0759764015674591,
0.09019425511360168,
-0.15662916004657745,
0.10734418034553528,
0.22207005321979523,
-0.019782977178692818,
-0.011016814969480038,
0.03688148036599159,
0.23408806324005127,
0.13695849478244781,
-0.03669194504618645,
0.09829122573137283,
-0.16659867763519287,
0.10829544067382812,
0.11545813083648682,
-0.07186093181371689,
-0.06334871798753738,
-0.15942718088626862,
0.29121848940849304,
0.07242732495069504,
-0.013222499750554562,
-0.14862871170043945,
-0.13340365886688232,
-0.052614957094192505,
0.4559542238712311,
-0.08577389270067215,
0.2663605511188507,
0.1646231859922409,
-0.05160699784755707,
-0.1296347975730896,
0.1456407606601715,
-0.06444267183542252,
0.04868708923459053,
-0.24916861951351166,
-0.1197248250246048,
0.11110279709100723,
-0.06236010044813156,
0.008411471731960773,
-0.035077501088380814,
0.22800444066524506,
0.1872033029794693,
0.1494835466146469,
0.0812777504324913,
0.06465939432382584,
-0.021017534658312798,
-0.23541681468486786,
0.05045025795698166,
-0.12251961976289749,
0.03430561348795891,
-0.09510932862758636,
-0.0020583097357302904,
-0.09316519647836685,
-0.04992654174566269,
0.09731941670179367,
0.2329801470041275,
0.07260266691446304,
0.0772412046790123,
0.147226020693779,
0.1575377732515335,
0.023011475801467896,
-0.07173983752727509,
-0.049612902104854584,
-0.1301371455192566,
0.19380800426006317,
0.06518067419528961,
-0.03709792718291283,
-0.1402350515127182,
0.025740990415215492,
-0.03697895631194115,
0.14752629399299622,
0.14189431071281433,
0.003015009220689535,
-0.04319809004664421,
-0.27671360969543457,
-0.1918119490146637,
0.05755158141255379,
0.018872831016778946,
-0.22373683750629425,
0.29783865809440613,
0.21121683716773987,
0.09728426486253738,
0.21001851558685303,
0.2624618709087372,
-0.14765478670597076,
0.07648447901010513,
-0.11566594243049622,
-0.09605436772108078,
-0.27545085549354553,
-0.1961955428123474,
-0.0954737663269043,
-0.3046795129776001,
-0.06575404107570648,
-0.06887143105268478,
-0.1103154718875885,
-0.142869770526886,
-0.14772607386112213,
0.22487233579158783,
0.3244680166244507,
-0.03484936058521271,
0.25319191813468933,
0.4567132890224457,
0.09529989212751389,
0.04961974918842316,
-0.15291568636894226,
-0.012922612950205803,
-0.0816107913851738,
0.45558246970176697,
-0.03261757269501686,
-0.08200927823781967,
0.09386854618787766,
-0.16766716539859772,
0.008030906319618225,
-0.19203941524028778,
0.00740852439776063,
0.15002131462097168,
-0.06316496431827545,
0.19044069945812225,
-0.09624127298593521,
-0.005847700405865908,
-0.11628071218729019,
-0.10780179500579834,
-0.1716001033782959,
0.08442538231611252,
0.11035662889480591,
-0.009259971790015697,
0.038134049624204636,
-0.05273398384451866,
0.12896846234798431,
0.16510887444019318,
-0.10125431418418884,
-0.0851435735821724,
-0.07397804409265518,
0.04845995828509331,
0.03665630519390106,
-0.03140430897474289,
-0.07986980676651001,
-0.02247484028339386,
0.06890339404344559,
0.010844909586012363,
-0.19470162689685822,
0.03910055011510849,
0.387931764125824,
0.15002581477165222,
0.18450772762298584,
0.14748694002628326,
0.08476503938436508,
0.054382964968681335,
-0.18092790246009827,
0.11739164590835571,
-0.10399179905653,
0.011566041968762875,
0.11953458189964294,
-0.07680873572826385,
-0.00939461961388588,
0.11790391057729721,
-0.10343708842992783,
0.18277554214000702,
-0.10708492249250412,
-0.0706973597407341,
0.09490722417831421,
-0.09160909801721573,
0.08595727384090424,
-0.13675665855407715,
0.3137636184692383,
0.053738463670015335,
0.11225239932537079,
-0.050656627863645554,
0.13589076697826385,
-0.026762457564473152,
0.06725515425205231,
-0.18183550238609314,
-0.05990930646657944,
-0.0572405606508255,
0.01768902689218521,
0.06787656247615814,
0.06724441051483154,
-0.11513162404298782,
-0.16422522068023682,
0.10294012725353241,
0.07416072487831116,
0.012153750285506248,
0.04466305673122406,
-0.04947065934538841,
0.11347568780183792,
-0.06592962145805359,
0.060901179909706116,
0.10701711475849152,
0.09469494968652725,
-0.11156395077705383,
-0.13008767366409302,
0.1152755469083786,
0.27701810002326965,
0.0054963682778179646,
0.07097912579774857,
-0.20900416374206543,
-0.03416094928979874,
0.05577370151877403,
-0.07359141111373901,
-0.1270422786474228,
0.18341605365276337,
-0.05521365627646446,
0.15479658544063568,
-0.008824716322124004,
0.04054678604006767,
-0.01663469895720482,
-0.09575564414262772,
0.07756887376308441,
-0.14171350002288818,
-0.45025330781936646,
0.046618055552244186,
0.11383887380361557,
-0.02358235977590084,
0.18387474119663239,
-0.00024178906460292637,
-0.0000335158001689706,
0.060171712189912796,
0.11929019540548325,
-0.016027403995394707,
0.10709672421216965,
-0.021221468225121498,
-0.12338865548372269,
0.14883564412593842,
-0.05661090835928917,
-0.333191841840744,
-0.018573537468910217,
0.062481533735990524,
0.20281800627708435,
0.26902860403060913,
-0.13100489974021912,
-0.10416532307863235,
-0.2319682240486145,
0.09486129879951477,
0.1617201566696167,
-0.14726564288139343,
0.0978274792432785,
-0.02829880826175213,
-0.13314424455165863,
-0.07565567642450333,
0.25827741622924805,
0.0638933777809143,
0.09181953221559525,
0.16759084165096283,
0.02453511394560337,
0.06606653332710266,
0.039345186203718185,
0.11697971820831299,
-0.18550947308540344,
-0.029142921790480614,
0.12622131407260895,
0.003339105984196067,
-0.20859010517597198,
0.04340329021215439,
0.16812552511692047,
0.1409424990415573,
0.056694146245718,
0.2719358205795288,
0.069759301841259,
0.01008027233183384,
-0.037896741181612015,
-0.10976634919643402,
0.047302551567554474,
0.10202565789222717,
-0.21382254362106323,
0.0888558179140091,
-0.12170527130365372,
-0.01674826443195343,
-0.14868885278701782,
-0.33213111758232117,
-0.07207643985748291,
0.05682818591594696,
-0.27163851261138916,
0.08660980314016342,
0.1694585084915161,
0.035002611577510834,
0.34318673610687256,
-0.08923250436782837,
0.1278626173734665,
0.36216604709625244,
0.04947838559746742,
-0.09236958622932434,
-0.03976402059197426,
-0.07274399697780609,
0.011064810678362846,
-0.11359696090221405,
0.10738937556743622,
0.0039002199191600084,
0.10828918218612671,
-0.03613617643713951,
0.06264927238225937,
-0.06592860817909241,
0.22099407017230988,
-0.20507444441318512,
-0.12207846343517303,
0.029763491824269295,
0.050374068319797516,
-0.1302592158317566,
0.10658016800880432,
-0.24688366055488586,
-0.15973486006259918,
0.0660029798746109,
0.09282509237527847,
0.08765237778425217,
0.12858280539512634,
-0.06084135174751282,
-0.1172202080488205,
-0.1264445185661316,
-0.12463460862636566,
-0.15791921317577362,
0.10081120580434799,
0.23220369219779968,
-0.18678762018680573,
-0.03771555796265602,
0.1901543289422989,
-0.21973684430122375,
-0.15794695913791656,
0.17749418318271637,
0.4287137985229492,
-0.3322784900665283,
0.2874859869480133,
0.024951696395874023,
0.1195516288280487,
0.08611851930618286,
0.06630203872919083,
0.10054059326648712,
-0.038557976484298706,
-0.07909595966339111,
0.1777636855840683,
0.20989003777503967,
0.03358495980501175,
0.05166549235582352,
-0.2556992769241333,
0.22015094757080078,
0.03628094494342804,
-0.025053760036826134,
0.015648363158106804,
0.1923670917749405,
0.1495065987110138,
0.24458378553390503,
-0.09496497362852097,
0.20976980030536652,
-0.28118857741355896,
0.16225016117095947,
0.04188161715865135,
-0.09082169085741043,
0.28093355894088745,
0.240773007273674,
-0.04692738130688667,
0.15165650844573975,
-0.22592559456825256,
0.07364993542432785,
-0.040346093475818634,
-0.05287144333124161,
-0.14500273764133453,
0.12552310526371002,
-0.059060122817754745,
0.03921304643154144,
0.0932156890630722,
0.10893987864255905,
0.11094306409358978,
0.20144188404083252,
0.17293749749660492,
0.09630443155765533,
0.06283741444349289,
-0.036648981273174286,
0.10946290194988251,
-0.020987635478377342,
0.013376704417169094,
-0.18061955273151398,
0.02206961065530777,
-0.08686242252588272,
-0.05008738487958908,
0.13443125784397125,
0.2635360062122345,
-0.13365203142166138,
-0.30692970752716064,
-0.22596363723278046,
0.28915050625801086,
0.0347660593688488,
-0.0045614116825163364,
-0.08540668338537216,
0.05758283659815788,
-0.109931580722332,
0.15699400007724762,
0.13095784187316895,
0.1287049949169159,
-0.035433027893304825,
-0.06430522352457047,
-0.01689891703426838,
0.2110697329044342,
0.0011284149950370193,
0.0824323445558548,
0.19314050674438477,
0.19013823568820953,
0.09882089495658875,
0.07896126061677933,
0.12858112156391144,
-0.1302877962589264,
-0.16596965491771698,
-0.1411161869764328,
0.15729019045829773,
-0.012365711852908134,
0.02375100553035736,
0.16717147827148438,
0.15911997854709625,
0.051834095269441605,
-0.20363524556159973,
0.10499390214681625,
0.005557172000408173,
-0.08672608435153961,
0.02384537272155285,
-0.10167089104652405,
-0.07229690998792648,
-0.03205307573080063,
0.019415471702814102,
0.09166157990694046,
0.2074597179889679,
-0.04381316155195236,
-0.2775295376777649,
-0.05651487037539482,
0.1824774444103241,
-0.14282086491584778,
0.1082705706357956,
0.06070907413959503,
-0.003186075249686837,
0.18736469745635986,
0.18488627672195435,
0.012659460306167603,
0.04035187140107155,
-0.25637421011924744,
0.09425561130046844,
-0.03177618980407715,
0.07600503414869308,
-0.09031207859516144,
-0.005691305734217167,
-0.14312078058719635,
0.05362841114401817,
-0.2446799874305725,
0.04455115646123886,
0.08328947424888611,
-0.17420655488967896,
-0.003011346096172929,
-0.0029873426537960768,
0.23067179322242737,
0.0027336538769304752,
0.07866057008504868,
-0.035143401473760605,
-0.07223641872406006,
0.3130112290382385,
0.2019898146390915,
0.06244167685508728,
-0.1514783352613449,
-0.2094901204109192,
0.08376730233430862,
-0.022825269028544426,
0.0034549825359135866,
-0.07583780586719513,
0.05458162724971771,
0.36229005455970764,
0.0810186117887497,
-0.11484269052743912,
-0.035611335188150406,
-0.21640825271606445,
0.10745658725500107,
0.19780361652374268,
0.2047700136899948,
-0.11814476549625397,
-0.168527752161026,
-0.0686793252825737,
0.008991139940917492,
-0.18185622990131378,
0.17418092489242554,
0.12064146995544434,
0.17482087016105652,
0.04201839864253998,
0.058490920811891556,
-0.2587659955024719,
0.04009408876299858,
0.12721878290176392,
0.02082524634897709,
-0.23197326064109802,
0.026947416365146637,
0.10059922933578491,
-0.19769947230815887,
-0.1546947956085205,
-0.18443448841571808,
-0.04511687904596329,
-0.06772750616073608,
0.07561250030994415,
-0.00015222944784909487,
-0.10444123297929764,
-0.15133686363697052,
-0.01736217923462391,
-0.031032567843794823,
-0.17327551543712616,
-0.00566842220723629,
0.25626277923583984,
-0.07350188493728638,
0.12343285977840424,
-0.13283739984035492,
0.10756518691778183,
0.04264756664633751,
-0.2659033536911011,
-0.12129665166139603,
0.07027789205312729,
-0.07622260600328445,
0.18848226964473724,
0.041115354746580124,
0.039056673645973206,
-0.1585475504398346,
0.004002015572041273,
0.08376947045326233,
-0.006303261499851942,
-0.22705596685409546,
0.09686542302370071,
-0.014132174663245678,
-0.030238615348935127,
-0.17047405242919922,
-0.12536437809467316,
-0.0349678136408329,
0.16218721866607666,
0.019768740981817245,
-0.04199788346886635,
-0.13123366236686707,
-0.11822988092899323,
-0.09817668795585632,
0.047324396669864655,
-0.044963203370571136,
-0.244094118475914,
-0.3484831750392914,
-0.06937431544065475,
-0.12701359391212463,
-0.11617744714021683,
-0.07222423702478409,
0.18419742584228516,
-0.006040941458195448,
-0.27138471603393555,
-0.01129099354147911,
0.023690704256296158,
-0.04985641688108444,
0.10436695069074631,
0.02431468665599823,
0.018929459154605865,
0.11557537317276001,
-0.10951108485460281,
0.1898205280303955,
-0.1477457880973816,
-0.08507341146469116,
-0.06162958964705467,
0.23994997143745422,
0.11978817731142044,
-0.05994141101837158,
-0.21771332621574402,
0.08598626405000687,
-0.06383441388607025,
-0.018070848658680916,
0.26888683438301086,
-0.07462934404611588,
-0.10450193285942078,
-0.02533695288002491,
0.1392325758934021,
0.1077907383441925,
-0.34972453117370605,
0.06004733592271805,
0.03599688038229942,
0.18071585893630981,
-0.10466648638248444,
0.1421663463115692,
-0.0311732180416584,
0.26538002490997314,
-0.013351227156817913,
0.009610140696167946,
-0.1309322565793991,
-0.04876180365681648,
-0.1965278685092926,
0.15495383739471436,
0.10049092769622803,
0.053916335105895996,
-0.29531994462013245,
-0.0890214741230011,
0.21159471571445465,
0.0725875273346901,
0.12830057740211487,
-0.009946528822183609,
0.20020462572574615,
-0.055445410311222076,
-0.05213483050465584,
0.0857943594455719,
0.1853143274784088,
-0.03159565106034279,
0.19211167097091675,
0.018016017973423004,
0.3674403131008148,
0.05179327726364136,
0.14539647102355957,
-0.09527085721492767,
0.06552903354167938,
-0.04279746115207672,
0.14595286548137665,
-0.08432824909687042,
0.27459874749183655,
-0.088229700922966,
0.030189119279384613,
0.14826178550720215,
-0.0870676189661026,
0.15465261042118073,
-0.02381270006299019,
-0.15077224373817444,
-0.00021679105702787638,
-0.02249153144657612,
-0.03635679930448532,
0.07407192140817642,
-0.0534626841545105,
0.11864493042230606,
-0.17681889235973358,
0.16478414833545685,
-0.17197059094905853,
-0.06887287646532059,
0.02156730554997921,
-0.014676297083497047,
0.11141112446784973,
0.13290950655937195,
-0.03751527518033981,
-0.07342161238193512,
-0.15459544956684113,
0.20934785902500153,
-0.007766080088913441,
-0.17798927426338196,
0.061184436082839966,
-0.06922699511051178,
-0.011657942086458206,
-0.1481984555721283,
-0.1762416660785675,
-0.16232675313949585,
0.19858764111995697,
-0.10935239493846893,
-0.34201857447624207,
-0.1286962628364563,
-0.0926419124007225,
0.09496089071035385,
0.08704419434070587,
-0.021904148161411285,
0.0596090704202652,
0.32800015807151794,
-0.004003711976110935,
-0.11136655509471893,
-0.11462583392858505,
0.2887154221534729,
0.22351646423339844,
-0.06910184770822525,
-0.20765288174152374,
0.06699135154485703,
0.2464451938867569,
0.05970039963722229,
-0.03934280946850777,
0.0901833102107048,
-0.04463143274188042,
-0.13545864820480347,
0.1123056709766388,
0.1175343245267868,
0.10107332468032837,
0.11945889890193939,
-0.1862240582704544,
-0.17917712032794952,
0.10524231940507889,
-0.044570256024599075,
-0.11277644336223602,
-0.14641901850700378,
0.05349314212799072,
0.050549060106277466,
0.034482192248106,
-0.18082518875598907,
-0.13754023611545563,
-0.10728654265403748,
0.11464455723762512,
0.05701974779367447,
0.05358511209487915,
-0.019143931567668915,
-0.12144307047128677,
0.055615298449993134,
-0.00995062105357647,
-0.10879402607679367,
0.04857482761144638,
0.2686517536640167,
-0.10830910503864288,
-0.16475170850753784,
-0.1265619844198227,
-0.16854055225849152,
0.25245752930641174,
-0.03775462508201599,
-0.05416688695549965,
0.12491773068904877,
0.04036272317171097,
-0.08168908953666687,
0.05655572563409805,
0.16727514564990997,
0.10217893123626709,
0.002696614246815443,
-0.02538885362446308,
0.22437886893749237,
0.16200971603393555,
-0.2106398493051529,
-0.06992149353027344,
-0.06035018712282181,
-0.07828722149133682,
0.1263105273246765,
-0.01823810115456581,
-0.06710482388734818,
0.1914731115102768,
0.10139536112546921,
-0.03494568541646004,
-0.13562673330307007,
-0.24528595805168152,
-0.08674771338701248,
0.11547968536615372,
-0.26256003975868225,
0.03864613547921181,
0.014011728577315807,
-0.020763782784342766,
-0.010288074612617493,
-0.18331308662891388,
-0.023482680320739746,
0.10511433333158493
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. , particularly the feet. However, individuals are reported with upper extremity involvement, including one with recurrent upper extremity ulceration beginning at age nine years , one with active ulcers on the hands , and one with a healed scar from prior ulcers in the dorsum of the hand . One had scarring from healed ulcers over most of her body; however, at the time of publication active ulcers were mainly on the legs .Skin ulcers can begin as early as age six months or as late as age 30 years .Ulceration is recurrent, and individual ulcers can take months to heal.Typically, no precipitating factors are identified with the appearance of an ulcer, although trauma has been reported as a triggering factor in at least two individuals . See Figure 1.Figure 1. Typical skin ulcerations in individuals with prolidase deficiency. A variety of skin findings can precede the appearance of ulcers by many years . In the first 20 patients reported , eight had telangiectasias of the face, shoulders, and hands; five | [
-0.03234780579805374,
0.1467503011226654,
-0.01807415299117565,
-0.20981672406196594,
0.07044125348329544,
0.0921241044998169,
-0.09287788718938828,
-0.046799156814813614,
-0.10852767527103424,
-0.2434576004743576,
0.16713181138038635,
0.09304293990135193,
0.23601792752742767,
0.05561169981956482,
-0.27074089646339417,
0.20347033441066742,
0.029199600219726562,
-0.02872440591454506,
-0.09676115214824677,
-0.003764098510146141,
-0.027551565319299698,
-0.20929233729839325,
0.2602125406265259,
0.019487975165247917,
0.2272077351808548,
-0.06047508120536804,
0.06411583721637726,
0.0945419892668724,
-0.08885077387094498,
0.1674102246761322,
-0.0338166318833828,
-0.11885546892881393,
-0.014313982799649239,
-0.18897810578346252,
0.15479108691215515,
0.043854258954524994,
-0.022658543661236763,
0.08589157462120056,
0.17558053135871887,
0.06023746356368065,
-0.16081276535987854,
-0.055118776857852936,
0.01885044015944004,
0.08070721477270126,
-0.05402418598532677,
-0.05883575975894928,
-0.05920401215553284,
0.0939645767211914,
-0.12410473078489304,
0.0790359154343605,
0.22635485231876373,
-0.019964171573519707,
0.015306676737964153,
0.07146624475717545,
0.1717301905155182,
0.1887480467557907,
-0.029677551239728928,
0.06118576228618622,
-0.1735004037618637,
0.08194547891616821,
0.1626749485731125,
-0.10096841305494308,
-0.04110007360577583,
-0.18243403732776642,
0.35720008611679077,
0.06060934066772461,
0.008364095352590084,
-0.10396115481853485,
-0.04427885264158249,
-0.03469674289226532,
0.3336320221424103,
-0.10147705674171448,
0.22125032544136047,
0.13113389909267426,
-0.06895043700933456,
-0.12069529294967651,
0.09049832075834274,
-0.053149838000535965,
-0.012848609127104282,
-0.2768421471118927,
-0.10453544557094574,
0.03034941293299198,
-0.09778717905282974,
0.11601771414279938,
-0.08253198117017746,
0.196609228849411,
0.19131143391132355,
0.09904801100492477,
0.1104239970445633,
0.10897468775510788,
-0.04735294729471207,
-0.24619926512241364,
0.04371943324804306,
-0.05040701851248741,
0.020893044769763947,
-0.09075021743774414,
-0.060217104852199554,
-0.08157205581665039,
-0.13668739795684814,
0.06888124346733093,
0.27268168330192566,
0.08542989194393158,
0.05436668172478676,
0.10062467306852341,
0.006685410626232624,
0.01597701944410801,
-0.05504599213600159,
0.016224918887019157,
-0.16768969595432281,
0.10718555748462677,
0.07142309844493866,
-0.10833639651536942,
-0.10446576029062271,
0.0012386090820655227,
-0.10335786640644073,
0.10771799087524414,
0.03980474919080734,
-0.0035498361103236675,
-0.10534059256315231,
-0.2887491285800934,
-0.11896933615207672,
-0.023675279691815376,
0.0036865242291241884,
-0.2777567207813263,
0.2408812940120697,
0.17930470407009125,
0.08058923482894897,
0.13251028954982758,
0.2578580677509308,
-0.11384379118680954,
0.04303857311606407,
-0.11983862519264221,
-0.12354569137096405,
-0.2874412536621094,
-0.07253308594226837,
-0.07725345343351364,
-0.29380589723587036,
-0.08324974030256271,
-0.11500614136457443,
-0.1281505972146988,
-0.029823902994394302,
-0.12181583046913147,
0.2721536457538605,
0.31329768896102905,
-0.08774586021900177,
0.11181387305259705,
0.4321909546852112,
0.16166263818740845,
0.002290733391419053,
-0.15424776077270508,
0.12645955383777618,
-0.03198776766657829,
0.4290803372859955,
0.024652687832713127,
-0.1093326136469841,
0.06772328168153763,
-0.13532377779483795,
-0.002420364646241069,
-0.17442947626113892,
-0.002384235616773367,
0.10957580804824829,
-0.0378967821598053,
0.09469625353813171,
-0.10670678317546844,
0.10137905925512314,
-0.02498040348291397,
-0.19913986325263977,
-0.22967657446861267,
0.06216423213481903,
0.12809787690639496,
0.0029988600872457027,
0.05261700227856636,
-0.0027566479984670877,
0.08600760996341705,
0.16619731485843658,
-0.04770486429333687,
-0.049172013998031616,
-0.019945278763771057,
0.028860215097665787,
0.027333714067935944,
-0.07855986058712006,
-0.022237159311771393,
-0.05895964801311493,
0.04930126667022705,
0.07694077491760254,
-0.18289406597614288,
0.05194518715143204,
0.261320024728775,
0.08125268667936325,
0.04953723028302193,
0.1757548451423645,
0.056290674954652786,
0.06526871770620346,
-0.20204386115074158,
0.12032484263181686,
-0.154988631606102,
-0.08584995567798615,
0.12521657347679138,
-0.06454924494028091,
0.10248295217752457,
0.13628409802913666,
-0.028871998190879822,
0.1796545535326004,
-0.16205286979675293,
-0.04176035150885582,
0.07330624759197235,
-0.033744923770427704,
0.1011708676815033,
-0.17900457978248596,
0.2991536557674408,
0.0800597295165062,
0.06458479911088943,
-0.04762580990791321,
0.03960002213716507,
0.012906554155051708,
0.09777286648750305,
-0.18383394181728363,
-0.10200666636228561,
-0.05840388312935829,
0.01379390899091959,
0.03505219146609306,
0.05568072199821472,
-0.1632562279701233,
-0.1327303946018219,
0.02658422850072384,
0.06924644112586975,
-0.036929693073034286,
0.03952822834253311,
-0.019103193655610085,
0.14894360303878784,
-0.09405220299959183,
0.08543427288532257,
0.02722085453569889,
0.019594019278883934,
-0.0946250632405281,
-0.14719931781291962,
0.1233673095703125,
0.2654869258403778,
0.045754991471767426,
0.08328182250261307,
-0.16170315444469452,
-0.04701138287782669,
0.008347392082214355,
-0.10492376983165741,
-0.13302388787269592,
0.2073579579591751,
-0.03115406446158886,
0.06712620705366135,
-0.04827841743826866,
0.0661957710981369,
-0.010572277940809727,
-0.12072979658842087,
0.14712855219841003,
-0.10895363986492157,
-0.36859285831451416,
0.05995272472500801,
0.13983486592769623,
-0.01721229963004589,
0.29837143421173096,
-0.09197553992271423,
0.061423130333423615,
0.07190749794244766,
0.11838582158088684,
-0.07887402176856995,
0.010240120813250542,
0.010816286318004131,
-0.11095509678125381,
0.21390491724014282,
-0.062312040477991104,
-0.3785818815231323,
-0.00666082464158535,
0.04732925444841385,
0.1850886195898056,
0.2190113514661789,
-0.06299682706594467,
-0.09135343134403229,
-0.22828309237957,
0.06923788785934448,
0.1813623607158661,
-0.04305927827954292,
0.14804254472255707,
-0.019284412264823914,
-0.13660462200641632,
-0.03782724216580391,
0.2776182293891907,
-0.0016960659995675087,
0.05455157533288002,
0.10142483562231064,
0.03602021187543869,
0.09305047243833542,
0.018773943185806274,
0.08465802669525146,
-0.0767391175031662,
-0.033059049397706985,
0.1666778177022934,
0.09556620568037033,
-0.22103938460350037,
0.04787260666489601,
0.16498742997646332,
0.11539001762866974,
0.09871719032526016,
0.1878577023744583,
0.03499370813369751,
0.1451503038406372,
-0.10735858976840973,
-0.148784801363945,
0.0015449976781383157,
0.06877008825540543,
-0.21483652293682098,
0.07576806098222733,
-0.10252095013856888,
-0.02376234345138073,
-0.11507748067378998,
-0.22668485343456268,
-0.127373605966568,
0.028340114280581474,
-0.2252497375011444,
0.09647466242313385,
0.20907488465309143,
0.0005406660493463278,
0.2577919065952301,
-0.17070312798023224,
0.0972367525100708,
0.32403501868247986,
0.07692273706197739,
-0.01007493119686842,
0.019341181963682175,
-0.009649787098169327,
-0.03467237576842308,
0.032068684697151184,
0.09018345922231674,
0.028612170368433,
0.044991616159677505,
-0.053066905587911606,
0.0326477587223053,
-0.018626879900693893,
0.24058020114898682,
-0.14721232652664185,
-0.040633752942085266,
-0.12018021941184998,
-0.017401989549398422,
-0.09856314212083817,
0.13743869960308075,
-0.26510316133499146,
-0.12511253356933594,
-0.008038847707211971,
0.1490553766489029,
0.09286952018737793,
0.0954505056142807,
-0.08178787678480148,
-0.09938656538724899,
-0.1526453197002411,
-0.12551254034042358,
-0.13939066231250763,
0.11137352138757706,
0.20093174278736115,
-0.22975309193134308,
-0.0700734406709671,
0.17433825135231018,
-0.23492878675460815,
-0.11432167142629623,
0.10245895385742188,
0.4262430667877197,
-0.3175792992115021,
0.36416181921958923,
0.021601473912596703,
0.0686153918504715,
0.11708979308605194,
0.0598079189658165,
0.05611854046583176,
0.008714110590517521,
-0.15355871617794037,
0.17069679498672485,
0.1694655567407608,
0.06861494481563568,
-0.005787499714642763,
-0.29119592905044556,
0.19857390224933624,
-0.04830464348196983,
-0.059416063129901886,
0.02258492261171341,
0.1792362481355667,
0.07085353136062622,
0.2609885036945343,
-0.060487113893032074,
0.1935890167951584,
-0.20109502971172333,
0.16946901381015778,
0.0641791895031929,
-0.1367563009262085,
0.23927339911460876,
0.20103749632835388,
0.050375796854496,
0.20249614119529724,
-0.140000581741333,
0.11966035515069962,
-0.06270257383584976,
-0.13023769855499268,
-0.2399941384792328,
0.10810944437980652,
-0.06868363916873932,
0.01822131872177124,
0.12571096420288086,
0.09089618176221848,
0.09293757379055023,
0.15495164692401886,
0.08624972403049469,
0.0943220928311348,
-0.05212194100022316,
0.0018382782582193613,
0.09583225101232529,
-0.006196281407028437,
0.13682688772678375,
-0.18700680136680603,
0.016953784972429276,
-0.11708570271730423,
-0.039848972111940384,
0.08217310905456543,
0.23079948127269745,
-0.19295622408390045,
-0.23982389271259308,
-0.19304534792900085,
0.28214189410209656,
-0.051077067852020264,
-0.039648350328207016,
-0.012089581228792667,
0.03539546579122543,
-0.08644465357065201,
0.1243581473827362,
0.1075119897723198,
0.2510252594947815,
0.023055022582411766,
-0.07207584381103516,
-0.051939547061920166,
0.2065422087907791,
-0.0492299385368824,
0.04825331270694733,
0.15145805478096008,
0.1788835972547531,
0.13129445910453796,
0.16044741868972778,
0.1648920774459839,
-0.15592753887176514,
-0.13491396605968475,
-0.09086078405380249,
0.09441843628883362,
-0.06170643866062164,
-0.0045532602816820145,
0.018523285165429115,
0.039789799600839615,
-0.008002342656254768,
-0.23565609753131866,
0.10263138264417648,
0.037505727261304855,
-0.08725718408823013,
0.0014467075234279037,
-0.13357855379581451,
-0.11087190359830856,
-0.01114780455827713,
0.016251610592007637,
-0.0020904799457639456,
0.1346817910671234,
0.043081220239400864,
-0.25536900758743286,
-0.06461228430271149,
0.1677471101284027,
-0.13318957388401031,
0.007278194651007652,
0.056418877094984055,
-0.007481512147933245,
0.1681373119354248,
0.07799424976110458,
0.020463038235902786,
0.002914395648986101,
-0.22404271364212036,
0.06907553970813751,
0.10000352561473846,
0.1080893725156784,
-0.12307851761579514,
0.02183879353106022,
-0.046805646270513535,
0.050813060253858566,
-0.14445216953754425,
-0.04227890446782112,
0.034114349633455276,
-0.05347295477986336,
0.06598542630672455,
-0.124283067882061,
0.24523037672042847,
-0.027056632563471794,
0.01263244915753603,
-0.07449262589216232,
0.023597821593284607,
0.3153192400932312,
0.22902080416679382,
-0.014452990144491196,
-0.09813350439071655,
-0.19850972294807434,
0.10737760365009308,
-0.09166955202817917,
-0.014677615836262703,
-0.14556871354579926,
0.0015256931073963642,
0.2962249517440796,
0.031714390963315964,
-0.10251231491565704,
-0.0443364642560482,
-0.2363944947719574,
0.09518188238143921,
0.0907852053642273,
0.20382072031497955,
-0.07074970752000809,
-0.09405214339494705,
-0.18378323316574097,
0.016802845522761345,
-0.1958436518907547,
0.12555687129497528,
0.23645615577697754,
0.1290106326341629,
0.02653208002448082,
0.11486432701349258,
-0.2604164779186249,
0.059329867362976074,
0.12654513120651245,
-0.029946696013212204,
-0.19127744436264038,
-0.0356215201318264,
0.04007963836193085,
-0.1860562413930893,
-0.23877300322055817,
-0.1974504292011261,
-0.12874898314476013,
-0.0051069981418550014,
0.08289345353841782,
0.023270124569535255,
-0.1802983433008194,
-0.08576834201812744,
-0.005181049928069115,
-0.0789676234126091,
-0.12003164738416672,
-0.04351607337594032,
0.20165862143039703,
-0.06246844679117203,
0.1282476931810379,
-0.25604861974716187,
0.04037947952747345,
0.04392889514565468,
-0.20942749083042145,
-0.17437829077243805,
0.019876180216670036,
-0.10339688509702682,
0.20066246390342712,
-0.02433919534087181,
0.04025894030928612,
-0.10087902843952179,
-0.05132649838924408,
0.06198151037096977,
0.0004266247560735792,
-0.16185003519058228,
0.038590576499700546,
-0.042609695345163345,
0.03824242576956749,
-0.06664584577083588,
-0.11400432884693146,
0.09391414374113083,
0.13698823750019073,
0.0072486610151827335,
-0.11295832693576813,
-0.12844103574752808,
-0.16593989729881287,
-0.055224478244781494,
0.010977252386510372,
-0.026358136907219887,
-0.290729284286499,
-0.2918332517147064,
-0.0856807604432106,
-0.12524868547916412,
-0.06026524677872658,
-0.10349466651678085,
0.1809910088777542,
0.043154723942279816,
-0.2636863589286804,
-0.02023054100573063,
-0.06517711281776428,
-0.03463098034262657,
0.21995817124843597,
-0.022779343649744987,
0.09571103006601334,
0.17178110778331757,
-0.05978025496006012,
0.14825110137462616,
-0.13804778456687927,
-0.08781569451093674,
-0.008893566206097603,
0.2306355983018875,
0.06400012224912643,
-0.060502443462610245,
-0.117365263402462,
0.05356185883283615,
-0.03073206916451454,
-0.017375444993376732,
0.2010260969400406,
-0.020975204184651375,
-0.03596128523349762,
0.009756461717188358,
0.17970281839370728,
0.1269591897726059,
-0.2589809000492096,
0.023744283244013786,
0.07116817682981491,
0.12360209971666336,
-0.11586465686559677,
0.17918233573436737,
0.03234589844942093,
0.2972220182418823,
-0.10784289985895157,
0.033817775547504425,
-0.07215500622987747,
-0.09917677938938141,
-0.23180174827575684,
0.1702890843153,
0.09255430102348328,
0.006137033458799124,
-0.257396936416626,
-0.07124098390340805,
0.24848155677318573,
0.13720305263996124,
0.02084757573902607,
0.09466554969549179,
0.15688437223434448,
-0.09747430682182312,
0.009655484929680824,
0.11006694287061691,
0.09778108447790146,
-0.002179927658289671,
0.147180438041687,
-0.0019192683976143599,
0.22777274250984192,
0.09087143838405609,
0.12051549553871155,
-0.07601620256900787,
0.12664319574832916,
-0.0017759245820343494,
0.06081234663724899,
-0.022844837978482246,
0.1823873668909073,
-0.03860572725534439,
-0.04469143971800804,
0.10005731880664825,
-0.03748828545212746,
0.21631306409835815,
-0.0350475087761879,
-0.06744448840618134,
-0.006910350173711777,
-0.17758497595787048,
-0.04300909861922264,
-0.021306216716766357,
-0.1564435511827469,
0.12157697975635529,
-0.21239575743675232,
0.1748008280992508,
-0.10523775964975357,
-0.0872172936797142,
0.13988317549228668,
-0.05103578045964241,
0.11200876533985138,
0.08313095569610596,
-0.06376079469919205,
-0.09028798341751099,
-0.1671237349510193,
0.13372761011123657,
-0.025629369542002678,
-0.1841232031583786,
0.04138520359992981,
-0.11904431134462357,
0.13884341716766357,
-0.13936084508895874,
-0.1655818372964859,
-0.1689024418592453,
0.08859212696552277,
-0.14938311278820038,
-0.31780439615249634,
-0.039483893662691116,
-0.1484786421060562,
0.053656455129384995,
0.09169170260429382,
-0.05410643666982651,
-0.01431721355766058,
0.25232741236686707,
-0.07996755838394165,
-0.1664227396249771,
-0.06004200130701065,
0.2821437120437622,
0.22537630796432495,
-0.08311592787504196,
-0.15076082944869995,
0.08899803459644318,
0.17655177414417267,
-0.039182908833026886,
-0.058871544897556305,
0.0840124636888504,
-0.08568532019853592,
-0.10800709575414658,
0.08599098771810532,
0.12635916471481323,
0.029994407668709755,
0.11213503032922745,
-0.22545084357261658,
-0.15550333261489868,
0.07174403220415115,
-0.016427258029580116,
-0.056504685431718826,
-0.1020151674747467,
0.09111487120389938,
0.05279428884387016,
0.03245912119746208,
-0.2281770259141922,
-0.028143351897597313,
-0.10833236575126648,
0.1759929209947586,
0.0818408876657486,
0.025397732853889465,
0.0496167317032814,
-0.04112039878964424,
0.06009083241224289,
-0.027194557711482048,
-0.01922738552093506,
-0.0859416127204895,
0.24555270373821259,
-0.0924140214920044,
-0.12581387162208557,
-0.09859077632427216,
-0.18054845929145813,
0.23138970136642456,
-0.06230302155017853,
-0.10009629279375076,
0.056094925850629807,
-0.04015279561281204,
-0.010976765304803848,
0.09360609203577042,
0.1275564730167389,
0.1404440850019455,
0.017789559438824654,
-0.004568289965391159,
0.19390298426151276,
0.10037634521722794,
-0.023102087900042534,
-0.020735127851366997,
-0.08834441751241684,
-0.08453252911567688,
0.1318938434123993,
0.031733475625514984,
-0.03750484436750412,
0.1773674339056015,
0.008186974562704563,
-0.04729684442281723,
-0.10739792883396149,
-0.1837541162967682,
0.00953380111604929,
0.14482353627681732,
-0.269477903842926,
-0.007454448379576206,
0.04608609899878502,
0.10254907608032227,
0.04683764651417732,
-0.08119111508131027,
-0.025589222088456154,
0.10984252393245697
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. age 30 years .Ulceration is recurrent, and individual ulcers can take months to heal.Typically, no precipitating factors are identified with the appearance of an ulcer, although trauma has been reported as a triggering factor in at least two individuals . See Figure 1.Figure 1. Typical skin ulcerations in individuals with prolidase deficiency. A variety of skin findings can precede the appearance of ulcers by many years . In the first 20 patients reported , eight had telangiectasias of the face, shoulders, and hands; five had scaly, erythematous, maculopapular lesions; and two had purpuric lesions in the absence of hematologic abnormalities. In addition, five had premature graying of the hair.Occasional findings:Lymphedema Hyperkeratosis of the elbows and knees Hirsutism Perioral pitted scars or radial scars As prolidase deficiency is associated with chronic recalcitrant lower extremity ulcers, an increased risk of squamous cell carcinoma of the skin could be expected, and indeed has been reported | [
-0.029295334592461586,
0.14767307043075562,
0.06148868054151535,
-0.13873769342899323,
0.1863727569580078,
0.11034324020147324,
0.0019212160259485245,
-0.047215066850185394,
-0.05392330139875412,
-0.22233349084854126,
0.2177884876728058,
0.12044085562229156,
0.26214632391929626,
-0.026278292760252953,
-0.23852506279945374,
0.24398085474967957,
-0.02222576178610325,
-0.06673461198806763,
-0.0811922550201416,
-0.07388992607593536,
-0.025917595252394676,
-0.16102947294712067,
0.2858363389968872,
-0.032483603805303574,
0.21990561485290527,
-0.09996431320905685,
0.004020618740469217,
0.0739303007721901,
-0.08559119701385498,
0.14990058541297913,
-0.010682531632483006,
-0.10131896287202835,
-0.0018871213542297482,
-0.1664000302553177,
0.12252030521631241,
0.03297079727053642,
-0.07024255394935608,
-0.004278127104043961,
0.21464158594608307,
0.009724525734782219,
-0.14783047139644623,
0.010100963525474072,
-0.05096035078167915,
0.051083266735076904,
-0.09288016706705093,
-0.03409096226096153,
-0.07884994149208069,
0.05090346559882164,
-0.15329328179359436,
0.07973570376634598,
0.24148273468017578,
-0.04125591740012169,
0.09094992280006409,
-0.012586302123963833,
0.16460669040679932,
0.13362492620944977,
-0.06859632581472397,
0.13310018181800842,
-0.17030708491802216,
0.081379733979702,
0.13005176186561584,
-0.07979011535644531,
-0.018284322693943977,
-0.27913376688957214,
0.3429568111896515,
0.08375725150108337,
-0.015359141863882542,
-0.032471075654029846,
-0.07775648683309555,
0.016364863142371178,
0.3252257704734802,
-0.1010148897767067,
0.2642597258090973,
0.08699754625558853,
-0.09319242089986801,
-0.14656467735767365,
0.0975143313407898,
-0.12952327728271484,
0.03679916262626648,
-0.24510861933231354,
-0.11370168626308441,
0.05404956638813019,
-0.15466438233852386,
0.12643560767173767,
-0.051600370556116104,
0.16046546399593353,
0.1826115995645523,
0.0919189453125,
0.17547006905078888,
0.0363118015229702,
-0.02226732298731804,
-0.15627345442771912,
0.02146417461335659,
-0.1314058005809784,
0.03867124393582344,
-0.1007751077413559,
-0.001713023753836751,
-0.10265296697616577,
-0.09818806499242783,
0.035011932253837585,
0.18396712839603424,
0.10385431349277496,
0.056770358234643936,
0.12030482292175293,
-0.0019749486818909645,
0.029790541157126427,
-0.037245552986860275,
0.03020680882036686,
-0.09611083567142487,
0.10991549491882324,
0.17485053837299347,
-0.0319136418402195,
-0.05009724199771881,
-0.026230232790112495,
-0.11261193454265594,
0.10496099293231964,
0.11307743936777115,
-0.018498938530683517,
-0.025675831362605095,
-0.29981961846351624,
-0.16109000146389008,
0.000864408619236201,
-0.03882141783833504,
-0.19920934736728668,
0.1911836415529251,
0.0673023909330368,
0.04772678762674332,
0.11943701654672623,
0.2911989390850067,
-0.010851453058421612,
-0.0072229476645588875,
-0.11200147122144699,
-0.046536657959222794,
-0.23204821348190308,
-0.1280086785554886,
-0.025059394538402557,
-0.32387247681617737,
-0.16826295852661133,
-0.12111011147499084,
-0.18613582849502563,
-0.04969019815325737,
-0.13990198075771332,
0.29740747809410095,
0.28670379519462585,
-0.08103011548519135,
0.13476695120334625,
0.38821691274642944,
0.13873586058616638,
0.0020863639656454325,
-0.044504329562187195,
0.14851592481136322,
-0.06393756717443466,
0.49079254269599915,
0.03432241454720497,
-0.0999593734741211,
0.1962050050497055,
-0.09692037850618362,
-0.018321728333830833,
-0.19528816640377045,
0.07886804640293121,
0.18640734255313873,
-0.052887529134750366,
0.15159285068511963,
-0.15265710651874542,
0.05297980085015297,
0.07086750864982605,
-0.11067584156990051,
-0.19963249564170837,
0.07934723794460297,
0.06929543614387512,
0.0135275823995471,
0.03704409673810005,
-0.03745201975107193,
0.07192624360322952,
0.14433832466602325,
-0.2047724425792694,
-0.022643636912107468,
-0.0037482832558453083,
0.005713391117751598,
-0.02278568223118782,
-0.027004435658454895,
-0.052728742361068726,
-0.10231960564851761,
0.026971468701958656,
0.11727956682443619,
-0.1544104963541031,
0.04812241718173027,
0.17281141877174377,
0.04853435233235359,
0.06916964054107666,
0.1468823254108429,
0.13219037652015686,
0.040602974593639374,
-0.16567525267601013,
0.08147136121988297,
-0.26440107822418213,
0.020177260041236877,
0.011349556036293507,
-0.11374109983444214,
0.05150775983929634,
0.2581127882003784,
-0.19557780027389526,
0.1041751280426979,
-0.09930237382650375,
-0.0506398007273674,
0.09085339307785034,
-0.03576887026429176,
0.09912921488285065,
-0.06030451878905296,
0.29661861062049866,
0.20019488036632538,
0.09513732045888901,
0.010906558483839035,
0.0763978362083435,
-0.0004404091159813106,
0.05690983310341835,
-0.1739356964826584,
-0.05766167864203453,
-0.01260300725698471,
-0.05479224771261215,
0.05071483552455902,
0.1285391002893448,
-0.036045514047145844,
-0.2913403809070587,
-0.025073960423469543,
0.17266923189163208,
-0.023319855332374573,
0.10172905772924423,
-0.07201891392469406,
0.20239640772342682,
-0.05633396655321121,
0.06566061079502106,
0.08646883815526962,
-0.02582615613937378,
-0.13430415093898773,
-0.1526835560798645,
0.13394582271575928,
0.30055126547813416,
0.012750470079481602,
0.015930667519569397,
-0.2816491425037384,
-0.02493683062493801,
-0.009589262306690216,
-0.06742137670516968,
-0.14102555811405182,
0.16340216994285583,
-0.01928624138236046,
0.16030748188495636,
-0.09442982822656631,
0.07380199432373047,
0.0004321998276282102,
-0.07073795795440674,
0.11030299216508865,
-0.13686849176883698,
-0.34739410877227783,
0.11839481443166733,
0.16398319602012634,
-0.07701470702886581,
0.2649018466472626,
0.02885502390563488,
0.07289155572652817,
0.04547871649265289,
0.0879465639591217,
-0.07096820324659348,
0.005698441062122583,
-0.0005065980367362499,
-0.09498349577188492,
0.20553578436374664,
-0.10179110616445541,
-0.35763272643089294,
0.006272041238844395,
0.07900061458349228,
0.20749469101428986,
0.15687422454357147,
-0.10792697966098785,
-0.10041429847478867,
-0.28386548161506653,
0.02663911134004593,
0.20901420712471008,
-0.05336108058691025,
0.11261395364999771,
-0.050758831202983856,
-0.14305265247821808,
-0.028014326468110085,
0.20099110901355743,
0.03588535264134407,
0.0013170429738238454,
0.07085097581148148,
-0.010321317240595818,
0.06564933061599731,
0.06770114600658417,
0.0652911439538002,
-0.10207517445087433,
-0.1078186184167862,
0.15211978554725647,
0.03217390179634094,
-0.18145260214805603,
-0.01917482353746891,
0.177775040268898,
0.11622697860002518,
0.2068175971508026,
0.16522620618343353,
0.09228350222110748,
0.11645781248807907,
-0.07631539553403854,
-0.04737650603055954,
-0.015985555946826935,
0.07958807796239853,
-0.24060729146003723,
0.0775681734085083,
-0.10294779390096664,
-0.04426401108503342,
-0.07002812623977661,
-0.21425101161003113,
-0.044739529490470886,
0.02123926766216755,
-0.18814630806446075,
0.04888496175408363,
0.19952410459518433,
0.019994592294096947,
0.2668773829936981,
-0.09390426427125931,
0.08285894989967346,
0.32508736848831177,
0.09729058295488358,
0.07754284888505936,
-0.06168990954756737,
-0.0012304476695135236,
-0.074432373046875,
0.0007275341777130961,
0.005470367148518562,
-0.027484120801091194,
0.11292121559381485,
-0.0008236643625423312,
0.015047469176352024,
0.05997796729207039,
0.22055496275424957,
-0.11476980894804001,
-0.1495039165019989,
-0.058926429599523544,
0.009232377633452415,
-0.049668747931718826,
0.044927217066287994,
-0.2511162757873535,
-0.08317915350198746,
0.018739797174930573,
0.12415273487567902,
0.09091223776340485,
0.08472302556037903,
-0.1610928326845169,
-0.07728251814842224,
-0.1370278298854828,
-0.06568875908851624,
-0.11802375316619873,
0.08555831015110016,
0.23189383745193481,
-0.14864730834960938,
-0.024766841903328896,
0.2503560185432434,
-0.22671617567539215,
-0.15036708116531372,
0.11059416830539703,
0.3738282322883606,
-0.23625099658966064,
0.3598242998123169,
0.09597067534923553,
0.07673841714859009,
0.054468411952257156,
0.0533769354224205,
-0.0045639765448868275,
0.10788889229297638,
-0.08026298880577087,
0.21026262640953064,
0.11937429755926132,
0.03270568326115608,
0.035214863717556,
-0.28182563185691833,
0.17816290259361267,
0.022176770493388176,
0.0005613081739284098,
0.006472891196608543,
0.21215000748634338,
0.12773337960243225,
0.2066352814435959,
0.0010914364829659462,
0.15341389179229736,
-0.2571335732936859,
0.16618621349334717,
0.038345880806446075,
-0.18206655979156494,
0.22141961753368378,
0.2091176062822342,
0.04520522803068161,
0.11564148962497711,
-0.15649795532226562,
0.16741082072257996,
-0.04658462479710579,
-0.07580186426639557,
-0.20446047186851501,
0.08109942823648453,
-0.014201702550053596,
-0.020973021164536476,
0.11380691826343536,
0.13934411108493805,
0.13020692765712738,
0.16067534685134888,
0.11060245335102081,
0.1099483072757721,
-0.002499226713553071,
0.026772497221827507,
0.027376975864171982,
-0.00830091442912817,
0.03751135244965553,
-0.16923083364963531,
-0.009194332174956799,
-0.15788263082504272,
-0.02767942287027836,
0.03619694709777832,
0.22819659113883972,
-0.11099658906459808,
-0.2339143455028534,
-0.2847951352596283,
0.19810593128204346,
0.052477698773145676,
-0.0915571004152298,
-0.027587514370679855,
0.083262138068676,
-0.1329260766506195,
0.12070352584123611,
0.08431122452020645,
0.19871793687343597,
-0.03286568820476532,
-0.004366468172520399,
-0.015781158581376076,
0.2646087408065796,
-0.01274014264345169,
0.06554155051708221,
0.07274103909730911,
0.21011203527450562,
0.11905794590711594,
0.16603681445121765,
0.16178305447101593,
-0.16751444339752197,
-0.13281822204589844,
-0.15926723182201385,
0.14330986142158508,
-0.05541606619954109,
0.045999739319086075,
0.0774361789226532,
0.035843972116708755,
0.0677347332239151,
-0.16508549451828003,
0.13205783069133759,
-0.035994067788124084,
-0.1945830136537552,
0.019151821732521057,
-0.0749359056353569,
-0.0692548081278801,
-0.00526627991348505,
0.033295825123786926,
0.02781773917376995,
0.13656875491142273,
0.0903385654091835,
-0.17740479111671448,
0.03825747221708298,
0.23296350240707397,
-0.17015381157398224,
-0.012287486344575882,
0.02737714722752571,
0.0018946750788018107,
0.16336774826049805,
0.10206276178359985,
0.057584527879953384,
0.036700084805488586,
-0.167006254196167,
0.08849457651376724,
-0.02491712011396885,
-0.057332031428813934,
-0.22208420932292938,
0.1807461678981781,
0.012881357222795486,
0.06866385787725449,
-0.24139206111431122,
-0.002320190193131566,
0.11402154713869095,
-0.005795973353087902,
0.05305399000644684,
-0.08677393198013306,
0.3334660828113556,
-0.0004190161998849362,
0.09653294831514359,
-0.016668107360601425,
0.04930027946829796,
0.3156220614910126,
0.1142616719007492,
-0.06357897073030472,
-0.054702386260032654,
-0.16282805800437927,
0.08137588202953339,
-0.06292814016342163,
0.07967189699411392,
-0.1383090317249298,
0.027613824233412743,
0.23430471122264862,
0.10448278486728668,
-0.09567134082317352,
-0.026616191491484642,
-0.22907133400440216,
0.14432393014431,
0.14378704130649567,
0.20895175635814667,
-0.1680370718240738,
-0.15238328278064728,
-0.29071205854415894,
-0.011992434039711952,
-0.1770939975976944,
0.16675175726413727,
0.16550688445568085,
0.19910216331481934,
0.006213042885065079,
0.10340394824743271,
-0.1804204285144806,
0.060486968606710434,
0.1356654018163681,
-0.09488600492477417,
-0.1585179716348648,
0.02517123706638813,
0.029177766293287277,
-0.23422767221927643,
-0.2232583463191986,
-0.22327719628810883,
-0.12099167704582214,
-0.06526432186365128,
-0.018278172239661217,
0.10516814142465591,
-0.08700130134820938,
-0.0609893873333931,
0.026900628581643105,
-0.0031261909753084183,
-0.06694647669792175,
-0.06745345145463943,
0.09679346531629562,
-0.08241034299135208,
0.20730723440647125,
-0.209160715341568,
0.053278349339962006,
-0.04464009776711464,
-0.18704786896705627,
-0.19272077083587646,
0.09517929702997208,
-0.15742121636867523,
0.13887102901935577,
-0.04427952691912651,
0.05534414201974869,
-0.07867929339408875,
-0.02077695168554783,
0.012474795803427696,
-0.06527598202228546,
-0.17431139945983887,
-0.017678648233413696,
-0.10926757007837296,
0.006178396288305521,
-0.16962917149066925,
-0.07461708039045334,
-0.014477274380624294,
0.2076626718044281,
-0.05506052449345589,
-0.01676301471889019,
-0.10019324719905853,
-0.19203859567642212,
-0.052699461579322815,
0.005716421641409397,
-0.03789525479078293,
-0.3192608952522278,
-0.2014799267053604,
-0.07067067921161652,
-0.1539292335510254,
-0.07296232879161835,
-0.0990920141339302,
0.10604724287986755,
-0.037550631910562515,
-0.15527743101119995,
0.02821889892220497,
0.017323704436421394,
-0.008127568289637566,
0.13704706728458405,
-0.04794660210609436,
0.15426397323608398,
0.14620812237262726,
-0.03978069871664047,
0.14810769259929657,
-0.14916640520095825,
-0.1337578445672989,
-0.05955766141414642,
0.18916328251361847,
0.05415136739611626,
0.003077760571613908,
-0.15040236711502075,
0.031734198331832886,
0.01727915182709694,
-0.06637779623270035,
0.16771796345710754,
-0.13742826879024506,
-0.08603452891111374,
-0.00018725014524534345,
0.13258963823318481,
0.1269443780183792,
-0.2596699297428131,
0.04290385916829109,
0.08437853306531906,
0.12532563507556915,
-0.24549894034862518,
0.16861629486083984,
-0.005937152076512575,
0.2616482675075531,
-0.09091418981552124,
0.0021067680791020393,
-0.13170351088047028,
-0.1325603574514389,
-0.21947358548641205,
0.15900419652462006,
0.1274016797542572,
0.05665832385420799,
-0.2924286723136902,
-0.0011671449756249785,
0.25504857301712036,
0.11493862420320511,
0.021248100325465202,
0.11111260950565338,
0.12476305663585663,
-0.04952109605073929,
0.003578472649678588,
0.043233875185251236,
0.15187817811965942,
-0.05892008915543556,
0.12086796015501022,
0.002549333730712533,
0.27307048439979553,
0.11616133898496628,
0.08116160333156586,
-0.04209167882800102,
0.0650523230433464,
-0.056400101631879807,
0.10159143060445786,
-0.10698404908180237,
0.22652001678943634,
-0.06807323545217514,
-0.045198723673820496,
0.10664820671081543,
-0.09450466930866241,
0.15517036616802216,
-0.016451498493552208,
-0.21712686121463776,
-0.013528138399124146,
-0.06484072655439377,
-0.08003092557191849,
-0.03343850001692772,
-0.1029893308877945,
0.050671134144067764,
-0.22097507119178772,
0.05911781266331673,
-0.11155173927545547,
-0.14267197251319885,
0.15294748544692993,
-0.07466430962085724,
0.09093452244997025,
0.10421803593635559,
-0.007061469834297895,
-0.13984650373458862,
-0.08817227929830551,
0.1935773640871048,
0.06112771853804588,
-0.09749390929937363,
0.030952297151088715,
-0.04307260364294052,
0.02273751050233841,
-0.08417122811079025,
-0.17050664126873016,
-0.20289947092533112,
0.0810229629278183,
-0.17273648083209991,
-0.3409513831138611,
-0.07215382158756256,
-0.04029737412929535,
0.15752528607845306,
0.08370508998632431,
-0.0297579076141119,
0.036990221589803696,
0.23940789699554443,
-0.01644214615225792,
-0.08670646697282791,
-0.07763119041919708,
0.13387736678123474,
0.19942989945411682,
-0.0912918671965599,
-0.1738792359828949,
0.11604943871498108,
0.15571658313274384,
-0.02140011079609394,
-0.04138341546058655,
0.042384322732686996,
0.01175626926124096,
-0.09686886519193649,
0.16121776401996613,
0.12331211566925049,
-0.004966443404555321,
0.09704313427209854,
-0.12650993466377258,
-0.15062519907951355,
0.06862372159957886,
-0.025002697482705116,
-0.045415427535772324,
-0.1552092730998993,
0.1948183923959732,
0.07875052094459534,
0.10520002990961075,
-0.18214894831180573,
-0.09827624261379242,
-0.0649217888712883,
0.2120308130979538,
0.03319833427667618,
0.0817040279507637,
-0.05335913971066475,
-0.022078508511185646,
0.02180057018995285,
0.039958655834198,
-0.06902619451284409,
-0.03729994595050812,
0.16245372593402863,
-0.11994972825050354,
-0.1742289960384369,
-0.16436436772346497,
-0.08478358387947083,
0.16907380521297455,
-0.005616147071123123,
-0.03572484478354454,
0.12340182811021805,
-0.037822425365448,
-0.032232657074928284,
0.10757500678300858,
0.1368512362241745,
0.15200790762901306,
-0.053307801485061646,
-0.03796372190117836,
0.1250295788049698,
0.032121043652296066,
-0.09802918136119843,
0.042212314903736115,
-0.11127988994121552,
-0.12241148948669434,
0.023429276421666145,
-0.01983199454843998,
-0.02721233293414116,
0.17393426597118378,
0.004453663248568773,
0.02226284146308899,
-0.09320322424173355,
-0.1931680142879486,
0.006654549390077591,
0.11676663160324097,
-0.22009575366973877,
-0.028472527861595154,
0.010892858728766441,
0.029339764267206192,
0.07200774550437927,
-0.02831398695707321,
-0.05245770514011383,
0.088237464427948
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. shoulders, and hands; five had scaly, erythematous, maculopapular lesions; and two had purpuric lesions in the absence of hematologic abnormalities. In addition, five had premature graying of the hair.Occasional findings:Lymphedema Hyperkeratosis of the elbows and knees Hirsutism Perioral pitted scars or radial scars As prolidase deficiency is associated with chronic recalcitrant lower extremity ulcers, an increased risk of squamous cell carcinoma of the skin could be expected, and indeed has been reported in one individual .Dysmorphic facial features. Although not a universal finding, facial features typically described include prominent forehead, widely spaced eyes, proptosis, depressed nasal bridge, prognathism, thin vermilion of the upper lip, and low anterior and posterior hairlines . See Figure 2.Figure 2. Prominent forehead, proptosis, depressed nasal bridge, and thin vermilion of the upper lip can be appreciated. Neurologic manifestations. Intellectual disability of | [
0.0439206138253212,
0.12605148553848267,
0.06560126692056656,
-0.23498576879501343,
0.11668943613767624,
-0.1353442221879959,
-0.01113063469529152,
0.03965208679437637,
-0.12100610136985779,
-0.21069052815437317,
0.1691628098487854,
0.22433508932590485,
0.2283303290605545,
0.009963111020624638,
-0.0748155489563942,
0.15919232368469238,
-0.0742260292172432,
0.04167071357369423,
-0.03760559856891632,
-0.224680095911026,
0.02131004072725773,
-0.07652334868907928,
0.36659762263298035,
-0.13162320852279663,
0.04675634577870369,
-0.07251439243555069,
0.0024650043342262506,
0.0568256713449955,
-0.029850872233510017,
0.033506087958812714,
0.03580520674586296,
-0.20374880731105804,
-0.08133907616138458,
-0.07455413043498993,
0.06132568418979645,
0.019659431651234627,
-0.11043272167444229,
-0.025959838181734085,
0.2179645299911499,
-0.06578139215707779,
-0.08024133741855621,
-0.020551234483718872,
-0.010364660061895847,
0.04001615568995476,
0.035212237387895584,
-0.15077275037765503,
-0.1147344633936882,
0.18731456995010376,
0.04314011335372925,
0.03328680247068405,
0.23376408219337463,
-0.19182801246643066,
0.12437084317207336,
-0.0888630673289299,
0.1115332841873169,
0.042134761810302734,
-0.09721901267766953,
0.09858756512403488,
-0.07987964153289795,
0.16008524596691132,
0.13803628087043762,
-0.18013359606266022,
0.11251366138458252,
-0.36321938037872314,
0.3590516149997711,
0.05884596332907677,
0.09912820160388947,
-0.024111859500408173,
-0.056908268481492996,
0.0549173504114151,
0.3320885896682739,
-0.06003331020474434,
0.14005930721759796,
0.01843283325433731,
-0.12414292991161346,
-0.04485549405217171,
0.11701837182044983,
-0.1352619230747223,
0.08699136972427368,
-0.17350706458091736,
-0.10937536507844925,
0.2401597946882248,
-0.11503180116415024,
0.1278170347213745,
-0.06221478432416916,
0.2420758605003357,
0.18331938982009888,
-0.019487304612994194,
0.04130962863564491,
0.05335504934191704,
-0.02297297678887844,
-0.1442267745733261,
0.11564624309539795,
-0.12097316980361938,
0.035850681364536285,
0.010472998954355717,
-0.0076341149397194386,
-0.05028980225324631,
-0.016402410343289375,
0.1867436319589615,
0.02923918329179287,
0.12301910668611526,
-0.006787552498281002,
0.031118521466851234,
-0.07814108580350876,
-0.138435497879982,
-0.008528388105332851,
0.009864035993814468,
-0.14351695775985718,
0.07183676213026047,
0.08332411199808121,
0.08223116397857666,
0.02883061394095421,
-0.07135472446680069,
-0.10368458181619644,
0.263529509305954,
0.09655977785587311,
-0.05391814932227135,
0.10354331135749817,
-0.24025197327136993,
-0.11172166466712952,
0.024704737588763237,
-0.016122909262776375,
-0.11634420603513718,
0.15950894355773926,
-0.09468895196914673,
-0.12912434339523315,
0.033616673201322556,
0.29632875323295593,
-0.04893619194626808,
0.05626480281352997,
-0.08596281707286835,
-0.00891463179141283,
-0.2126716673374176,
-0.21463796496391296,
-0.003178464947268367,
-0.4488144814968109,
-0.24634085595607758,
0.014276235364377499,
-0.06950446218252182,
0.08284018188714981,
-0.0633804127573967,
0.28000643849372864,
0.21944116055965424,
0.011521229520440102,
0.08049701899290085,
0.24424946308135986,
0.19403009116649628,
0.019916070625185966,
-0.024499129503965378,
0.1922258883714676,
-0.06646143645048141,
0.4121823310852051,
0.003240430261939764,
-0.23854102194309235,
0.2876245975494385,
-0.11111696809530258,
-0.08785498887300491,
-0.22596345841884613,
0.039737552404403687,
0.1817905604839325,
-0.06851829588413239,
0.12373726069927216,
-0.17745673656463623,
0.11792264133691788,
0.13079723715782166,
-0.1598806530237198,
-0.19687257707118988,
0.196055069565773,
0.13688476383686066,
-0.08385328948497772,
0.01766829378902912,
-0.06934427469968796,
-0.03816289082169533,
0.0449339784681797,
-0.08059804141521454,
-0.0847485363483429,
0.11740533262491226,
0.021295392885804176,
-0.11258046329021454,
0.006702589802443981,
-0.0624188631772995,
-0.17883573472499847,
-0.17028698325157166,
0.177526593208313,
-0.21199814975261688,
0.012754518538713455,
0.08126544952392578,
0.038200583308935165,
0.05091235786676407,
0.16925135254859924,
0.11248750239610672,
-0.061880577355623245,
-0.2088354527950287,
-0.038404278457164764,
-0.33561915159225464,
0.1397983580827713,
-0.1609078347682953,
-0.12416146695613861,
0.024936454370617867,
0.41251009702682495,
-0.16587115824222565,
-0.03331398218870163,
-0.1011594757437706,
-0.1805756837129593,
0.08548936247825623,
-0.0015033393865451217,
-0.06311308592557907,
0.011393639259040356,
0.2785857915878296,
0.13556712865829468,
0.06132427603006363,
0.09789568185806274,
0.08568347245454788,
0.023004867136478424,
0.10140228271484375,
-0.09989168494939804,
-0.08370775729417801,
-0.023836495354771614,
-0.09219426661729813,
0.03769305348396301,
0.17762687802314758,
-0.09382488578557968,
-0.21497178077697754,
-0.07539739459753036,
0.13138897716999054,
0.031206294894218445,
0.10789546370506287,
-0.0579717718064785,
0.07121019810438156,
-0.1036120355129242,
0.06262072175741196,
0.1055547297000885,
0.02872488647699356,
0.061515264213085175,
-0.23202243447303772,
0.12854363024234772,
0.23596073687076569,
-0.0019781652372330427,
0.08427726477384567,
-0.31299281120300293,
-0.02914421446621418,
-0.066924549639225,
-0.0976390615105629,
-0.18591150641441345,
0.1931914985179901,
-0.12379545718431473,
0.12209152430295944,
0.053417231887578964,
0.026236943900585175,
0.04215270280838013,
-0.01761726289987564,
0.06539202481508255,
-0.1326616108417511,
-0.3558960556983948,
0.0743512213230133,
0.2150154709815979,
-0.046228405088186264,
0.13444995880126953,
0.0763101652264595,
0.054581452161073685,
0.07147302478551865,
-0.02224421128630638,
-0.100605808198452,
-0.12299743294715881,
-0.036230795085430145,
-0.11120099574327469,
0.1808541715145111,
-0.13218219578266144,
-0.2596230208873749,
-0.03686597943305969,
0.03945706784725189,
0.042880333960056305,
0.13085030019283295,
-0.1754784882068634,
0.007606156170368195,
-0.3157537281513214,
0.035564593970775604,
0.23513059318065643,
0.016255613416433334,
0.21202589571475983,
-0.1919766515493393,
-0.11499269306659698,
-0.07108942419290543,
0.22302423417568207,
0.040806844830513,
0.017299778759479523,
0.09602528065443039,
0.024339552968740463,
-0.05200764909386635,
0.04831003025174141,
0.06134343147277832,
0.0034637905191630125,
-0.19830961525440216,
0.042400870472192764,
0.1301141083240509,
-0.009409965015947819,
0.08925018459558487,
0.14452114701271057,
0.1545865684747696,
0.10052740573883057,
0.07681351155042648,
0.20013633370399475,
0.114232137799263,
-0.10721050947904587,
-0.11411862820386887,
-0.06330158561468124,
0.08940129727125168,
-0.32351434230804443,
0.055371906608343124,
-0.18376898765563965,
0.018012480810284615,
0.1147322729229927,
-0.08178529888391495,
0.1081908568739891,
-0.048187535256147385,
-0.2926887571811676,
0.12167950719594955,
0.11504054069519043,
0.019698061048984528,
0.21333743631839752,
-0.17571985721588135,
0.09734296053647995,
0.35617631673812866,
0.002953415969386697,
0.06369094550609589,
-0.23723040521144867,
-0.02728552184998989,
-0.06289773434400558,
0.12272210419178009,
0.04544086754322052,
-0.010845210403203964,
0.07257693260908127,
0.014543231576681137,
-0.10150805860757828,
-0.06829012930393219,
0.16519680619239807,
0.007176653482019901,
-0.21193760633468628,
-0.042083948850631714,
0.042924173176288605,
-0.13014107942581177,
0.04241597279906273,
-0.24178028106689453,
-0.036855071783065796,
-0.025037888437509537,
0.2476544827222824,
0.01164456456899643,
0.2476482093334198,
-0.24439637362957,
0.008789079263806343,
-0.08931725472211838,
-0.13831980526447296,
-0.21244248747825623,
0.028267573565244675,
0.1276424080133438,
-0.3199898898601532,
-0.030732812359929085,
0.3142731487751007,
-0.14298157393932343,
-0.19657304883003235,
-0.046387575566768646,
0.24180975556373596,
-0.16312478482723236,
0.357740193605423,
0.22461305558681488,
0.03632201999425888,
-0.09411333501338959,
0.09455175697803497,
-0.06307119876146317,
0.10758814960718155,
0.11921032518148422,
0.15899121761322021,
0.08883445709943771,
-0.03215958923101425,
-0.04315393418073654,
-0.33660417795181274,
0.3429708778858185,
0.014858194626867771,
0.03098968043923378,
-0.044894956052303314,
0.2629416584968567,
0.14227186143398285,
0.09683104604482651,
0.0022599506191909313,
0.1533762663602829,
-0.2860338091850281,
0.09085030108690262,
-0.0005641197203658521,
-0.14271682500839233,
0.10457175225019455,
0.16418272256851196,
0.18763171136379242,
0.09712710976600647,
-0.11958560347557068,
0.22461730241775513,
-0.10838531702756882,
0.07294487953186035,
-0.1076633483171463,
0.0038158774841576815,
0.030675113201141357,
-0.050942156463861465,
-0.02629062347114086,
0.029710551723837852,
0.15909545123577118,
0.17024406790733337,
-0.01378838811069727,
0.26645782589912415,
-0.1508123129606247,
-0.00667588273063302,
0.11233105510473251,
-0.1077304407954216,
-0.11752397567033768,
-0.07804638147354126,
-0.027009708806872368,
-0.05077362060546875,
-0.03292274475097656,
0.05905560776591301,
0.17360280454158783,
-0.022826513275504112,
-0.20469136536121368,
-0.2619270980358124,
0.07716250419616699,
0.04761625453829765,
-0.037631552666425705,
-0.06889927387237549,
0.11745224893093109,
-0.06495139747858047,
0.15643353760242462,
-0.032114896923303604,
0.04526956379413605,
-0.10777889937162399,
0.17824412882328033,
0.03174510970711708,
0.2092929631471634,
0.006854059174656868,
0.03395495191216469,
-0.12852919101715088,
0.26450636982917786,
0.01420518010854721,
0.05360759049654007,
0.1328599900007248,
-0.2868562340736389,
-0.18467438220977783,
0.06396262347698212,
0.06858421862125397,
0.00995363388210535,
0.08788299560546875,
-0.00529010035097599,
0.003674819367006421,
0.14957904815673828,
-0.22348247468471527,
0.08951977640390396,
0.08637460321187973,
-0.13647019863128662,
0.0015942625468596816,
-0.10074276477098465,
-0.14751829206943512,
-0.005103179253637791,
0.02286655828356743,
-0.056480731815099716,
-0.006594214588403702,
0.17363370954990387,
-0.18079671263694763,
0.05590211600065231,
0.048995241522789,
-0.21555915474891663,
-0.12050434201955795,
0.056505236774683,
0.020116271451115608,
0.14859843254089355,
0.13637563586235046,
0.03150496631860733,
-0.12267136573791504,
-0.15558579564094543,
0.030894123017787933,
0.00855744257569313,
-0.06135852262377739,
-0.2514537572860718,
0.3437354862689972,
-0.11677414178848267,
-0.06135309115052223,
-0.27492403984069824,
-0.09874943643808365,
-0.00951335672289133,
0.052946846932172775,
-0.04659762978553772,
-0.05345135182142258,
0.3780645728111267,
-0.09179385006427765,
0.1146014928817749,
0.0014037921791896224,
0.09541191905736923,
0.2327551394701004,
0.13437393307685852,
0.03490644693374634,
-0.014806972816586494,
0.06276963651180267,
0.2169051617383957,
-0.030161136761307716,
0.024277573451399803,
0.05609948933124542,
-0.0768335610628128,
0.17320828139781952,
0.07336519658565521,
0.0973559021949768,
0.05448608845472336,
-0.25019723176956177,
0.19033198058605194,
-0.00005555694588110782,
0.2656790316104889,
-0.14777880907058716,
-0.15088416635990143,
-0.22924742102622986,
0.10351172834634781,
-0.20205241441726685,
0.1962970793247223,
0.024202048778533936,
0.19481238722801208,
-0.19065353274345398,
0.08022285997867584,
-0.05018153041601181,
0.048430804163217545,
0.034526024013757706,
-0.10054013133049011,
-0.08161231875419617,
0.09780548512935638,
0.0041515217162668705,
-0.08965889364480972,
-0.24608218669891357,
-0.1887827068567276,
-0.07906155288219452,
-0.11689826101064682,
0.02596825547516346,
0.09328042715787888,
-0.2583623230457306,
0.018409674987196922,
0.06601130962371826,
0.0659206211566925,
-0.0026742969639599323,
-0.09477590769529343,
0.12308749556541443,
-0.13315190374851227,
0.15862533450126648,
-0.10934239625930786,
0.11939563602209091,
-0.032693687826395035,
-0.0444314181804657,
-0.13879068195819855,
0.10261131823062897,
-0.12070433795452118,
0.0857686772942543,
-0.10907506942749023,
0.12155822664499283,
-0.03171415254473686,
-0.1478152871131897,
0.09976250678300858,
-0.1611907035112381,
-0.10160443186759949,
0.09057141095399857,
-0.19953832030296326,
-0.05832650884985924,
-0.09424189478158951,
-0.11957667768001556,
-0.10219026356935501,
0.23131537437438965,
0.03579409793019295,
0.023304544389247894,
-0.11637594550848007,
-0.2876823842525482,
0.061883825808763504,
-0.042206306010484695,
0.0015746952267363667,
-0.13933974504470825,
-0.16350090503692627,
-0.20330442488193512,
-0.25074928998947144,
-0.16233648359775543,
-0.16123925149440765,
0.10488888621330261,
-0.07048701494932175,
0.044101689010858536,
-0.1492076814174652,
0.24920564889907837,
0.06795381009578705,
0.14214329421520233,
-0.026133226230740547,
0.11426521092653275,
0.16080453991889954,
-0.06675779819488525,
0.21340708434581757,
-0.1962960958480835,
0.024398788809776306,
-0.07085689902305603,
0.26798194646835327,
0.08165639638900757,
-0.025887897238135338,
-0.0034986529499292374,
0.07753083109855652,
0.0960889533162117,
-0.051330044865608215,
0.2265259176492691,
-0.08295368403196335,
-0.08424264192581177,
0.01692500151693821,
0.21447671949863434,
0.17189006507396698,
-0.19557549059391022,
0.16754306852817535,
0.028840631246566772,
0.11018475145101547,
-0.1853748857975006,
0.10736831277608871,
0.038548775017261505,
0.27690818905830383,
-0.10806066542863846,
0.030221527442336082,
-0.025103315711021423,
-0.06317057460546494,
-0.13010838627815247,
0.22745326161384583,
0.12861262261867523,
0.13412560522556305,
-0.2985977828502655,
0.007557498756796122,
0.17246784269809723,
0.19592511653900146,
0.09955485910177231,
0.03168918937444687,
0.03342955932021141,
-0.019829172641038895,
-0.10950534045696259,
0.1513664275407791,
0.08073731511831284,
-0.279561847448349,
0.16408663988113403,
-0.021053588017821312,
0.18595515191555023,
0.32992324233055115,
0.08636076748371124,
0.004525466356426477,
0.10293369740247726,
0.1305759698152542,
0.17961011826992035,
-0.05999111011624336,
0.2736680507659912,
0.02014200948178768,
-0.053163088858127594,
-0.08314645290374756,
-0.17005890607833862,
0.14274969696998596,
-0.008752617053687572,
-0.23753206431865692,
0.05481354519724846,
0.026010314002633095,
-0.06826763600111008,
-0.09168479591608047,
-0.10938409715890884,
0.10656733810901642,
-0.1175205335021019,
-0.02301775850355625,
-0.11170147359371185,
-0.14659123122692108,
0.14039334654808044,
-0.042485471814870834,
0.1317966878414154,
0.005114948842674494,
0.03848275542259216,
-0.13662146031856537,
-0.060758076608181,
0.1222023144364357,
0.030088646337389946,
-0.022982433438301086,
-0.09148117899894714,
-0.041815660893917084,
0.05020368844270706,
-0.07957927137613297,
-0.2215399444103241,
-0.19439195096492767,
0.06072520837187767,
-0.0683189257979393,
-0.39388906955718994,
0.020977146923542023,
0.08917555212974548,
0.15779848396778107,
0.29362478852272034,
0.06386247277259827,
0.06147505342960358,
0.05629429966211319,
0.011408038437366486,
-0.014090899378061295,
0.0210866741836071,
0.004436342045664787,
0.1601485162973404,
-0.11750853806734085,
-0.1462116688489914,
0.24468116462230682,
0.22018486261367798,
-0.05275562405586243,
0.08621560037136078,
0.11142545193433762,
-0.10153146088123322,
-0.020277904346585274,
0.17649434506893158,
0.23385009169578552,
-0.015058756805956364,
0.2221418023109436,
-0.04093537852168083,
-0.0488310232758522,
0.015998711809515953,
0.12046455591917038,
-0.010350448079407215,
-0.05766844376921654,
0.34804096817970276,
0.2309304028749466,
0.07829928398132324,
-0.11781737208366394,
-0.026809263974428177,
-0.1042550578713417,
0.2409832775592804,
0.08146452903747559,
0.23666289448738098,
-0.08782260864973068,
-0.05599178746342659,
0.0037266607396304607,
0.03774460032582283,
0.05307392776012421,
-0.04974573850631714,
0.15306933224201202,
-0.16201460361480713,
-0.11381067335605621,
-0.2115829885005951,
-0.0409066416323185,
0.09705688059329987,
-0.12661710381507874,
0.12419892847537994,
-0.05594398081302643,
-0.03208518400788307,
-0.12116103619337082,
0.016562748700380325,
0.24286606907844543,
0.19360104203224182,
-0.20038802921772003,
0.003155831480398774,
0.028718093410134315,
-0.013871302828192711,
-0.030875567346811295,
0.16726402938365936,
-0.11008653044700623,
-0.030530065298080444,
-0.08246023207902908,
-0.11525829881429672,
0.08606287091970444,
0.03511429205536842,
-0.016585709527134895,
0.21237826347351074,
-0.03465420380234718,
-0.09803862869739532,
-0.07831142842769623,
-0.00644428376108408,
-0.1495484560728073,
-0.021941479295492172,
-0.05108708143234253,
-0.008332537487149239,
0.017398085445165634,
0.046837858855724335,
-0.01795131526887417,
-0.02690626122057438
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. , and indeed has been reported in one individual .Dysmorphic facial features. Although not a universal finding, facial features typically described include prominent forehead, widely spaced eyes, proptosis, depressed nasal bridge, prognathism, thin vermilion of the upper lip, and low anterior and posterior hairlines . See Figure 2.Figure 2. Prominent forehead, proptosis, depressed nasal bridge, and thin vermilion of the upper lip can be appreciated. Neurologic manifestations. Intellectual disability of variable degree has been described in approximately 75% of individuals with prolidase deficiency . Table 3 summarizes IQ scores reported in the medical literature to date.In a review 12 of 30 individuals with molecularly confirmed prolidase deficiency had intellectual disability .In a case series of 12 individuals with prolidase deficiency, one had speech delay, two had mild developmental delay, and six had intellectual disability; three had no delays .In a case series of 20 Druze and Arab Muslims | [
0.054768480360507965,
0.13551920652389526,
-0.07549985498189926,
-0.25360462069511414,
0.07975801825523376,
-0.16048669815063477,
-0.09281867742538452,
-0.021962087601423264,
-0.0010595791973173618,
-0.07485852390527725,
0.09691336750984192,
0.1755705028772354,
0.1183820515871048,
0.09012001007795334,
-0.024665705859661102,
0.06904910504817963,
0.010116799734532833,
0.008163782767951488,
-0.06856884807348251,
-0.11823660880327225,
0.0279585812240839,
-0.013534469529986382,
0.3049949109554291,
0.03923250734806061,
0.015427191741764545,
-0.12848840653896332,
0.0625559389591217,
0.056605320423841476,
0.047095272690057755,
-0.06883883476257324,
0.050545092672109604,
-0.04312397167086601,
-0.12814927101135254,
-0.1220925822854042,
-0.02052129991352558,
-0.04394931718707085,
-0.08060178905725479,
-0.046911586076021194,
0.1434566229581833,
-0.1312011182308197,
-0.13520567119121552,
-0.010688611306250095,
0.08298254758119583,
-0.053264521062374115,
0.15859848260879517,
-0.11179238557815552,
-0.07359577715396881,
0.15849018096923828,
0.07244113087654114,
0.030960803851485252,
0.17465808987617493,
-0.11682453006505966,
0.13197819888591766,
-0.14860039949417114,
0.11202728003263474,
0.06824402511119843,
-0.05582856014370918,
-0.027337832376360893,
-0.054463423788547516,
0.16615785658359528,
0.14051707088947296,
-0.1517932116985321,
0.07558595389127731,
-0.44164687395095825,
0.2619881331920624,
0.0010924672242254019,
0.17970451712608337,
-0.03994572535157204,
-0.06817221641540527,
-0.09170433133840561,
0.23248228430747986,
-0.07685575634241104,
0.10304474085569382,
0.010650615207850933,
-0.15721943974494934,
-0.0441875159740448,
0.10470391064882278,
-0.16835512220859528,
0.1468631774187088,
-0.15788981318473816,
-0.11482793092727661,
0.27164357900619507,
-0.043850015848875046,
0.06111743673682213,
-0.04037623107433319,
0.19352181255817413,
0.19816939532756805,
-0.05604173615574837,
-0.006631595082581043,
0.018746189773082733,
0.0036488950718194246,
-0.18164649605751038,
0.0932478979229927,
-0.229454904794693,
0.0854073017835617,
-0.013437553308904171,
0.06742356717586517,
-0.06287006288766861,
-0.11408647894859314,
0.2179950475692749,
-0.032242875546216965,
0.09664712101221085,
-0.04779955372214317,
0.037525858730077744,
0.009741772897541523,
-0.12302495539188385,
-0.029247893020510674,
0.04607728496193886,
-0.13129086792469025,
-0.006942839361727238,
-0.01705021969974041,
-0.04831422492861748,
0.03706080839037895,
-0.07230798900127411,
-0.04543941840529442,
0.18292397260665894,
0.1173362210392952,
0.003154305275529623,
0.08852139860391617,
-0.08735442161560059,
-0.06945475935935974,
0.05971236899495125,
-0.03650128096342087,
-0.055633485317230225,
0.23494157195091248,
-0.09747649729251862,
-0.07976219058036804,
0.07123930752277374,
0.23811815679073334,
-0.017311666160821915,
0.0683986246585846,
-0.003739207284525037,
0.006177188828587532,
-0.11574055999517441,
-0.21351049840450287,
-0.018809974193572998,
-0.4322093725204468,
-0.2456579953432083,
0.043772194534540176,
-0.003627170342952013,
0.1978352814912796,
-0.06980463117361069,
0.22178113460540771,
0.1674298197031021,
0.05892787128686905,
0.04148545861244202,
0.13042891025543213,
0.1303178071975708,
-0.008654830977320671,
0.029918169602751732,
0.0861232727766037,
0.011842899024486542,
0.34711846709251404,
-0.04632319137454033,
-0.1074720025062561,
0.12752023339271545,
-0.11274570971727371,
-0.037780992686748505,
-0.14665044844150543,
0.0801439955830574,
0.07172275334596634,
-0.04283551871776581,
0.13441188633441925,
-0.09608177095651627,
0.01677626371383667,
0.020187968388199806,
-0.1517103761434555,
-0.015629345551133156,
0.12881039083003998,
0.11840386688709259,
-0.10332734882831573,
0.13848371803760529,
-0.13483883440494537,
-0.058011870831251144,
0.037955138832330704,
0.013718318194150925,
-0.02499018982052803,
0.19190993905067444,
0.00559498043730855,
-0.18154461681842804,
0.09376716613769531,
-0.08040793985128403,
-0.11689910292625427,
-0.1840628981590271,
0.013123818673193455,
-0.11148209124803543,
0.010192595422267914,
0.1404736340045929,
-0.015501766465604305,
0.05799838900566101,
0.06592211872339249,
0.07322632521390915,
-0.08302483707666397,
-0.06748273968696594,
-0.00048095002421177924,
-0.3170311450958252,
0.1833546906709671,
-0.21501892805099487,
-0.11283908039331436,
-0.025788158178329468,
0.40663573145866394,
-0.18961864709854126,
0.014717373065650463,
0.03359763324260712,
-0.24584846198558807,
0.02335379086434841,
-0.04615738242864609,
-0.1471964716911316,
-0.0418216809630394,
0.24231567978858948,
0.11292489618062973,
0.06273114681243896,
0.03674653172492981,
0.18935514986515045,
0.018031025305390358,
0.03788242116570473,
0.02368801087141037,
-0.10017310082912445,
-0.1322033703327179,
-0.037015095353126526,
0.002096610376611352,
0.25255686044692993,
-0.07541345059871674,
-0.1544887274503708,
-0.12542061507701874,
0.10309232026338577,
-0.007370673585683107,
0.05115967243909836,
-0.1220242977142334,
0.011341423727571964,
-0.07488410919904709,
-0.0010872094426304102,
0.03135603293776512,
0.029984954744577408,
0.049098704010248184,
-0.10864142328500748,
0.01475586835294962,
0.2111070603132248,
0.003295649541541934,
0.012228237465023994,
-0.2582090198993683,
-0.015389611013233662,
0.06747163087129593,
-0.007556744385510683,
-0.2393805980682373,
0.01318306103348732,
-0.10922665894031525,
0.05359272658824921,
0.1024206206202507,
0.05403319373726845,
0.017226291820406914,
-0.002817991655319929,
0.050009585916996,
-0.05250280722975731,
-0.3891119360923767,
0.031145913526415825,
0.22823861241340637,
0.040618885308504105,
0.03781593218445778,
0.030183037742972374,
0.020359599962830544,
0.04914040118455887,
-0.12167467176914215,
-0.0681663453578949,
-0.1137688010931015,
-0.16500474512577057,
-0.07466179877519608,
0.04905401170253754,
-0.08067415654659271,
-0.20285676419734955,
-0.09532691538333893,
0.14797981083393097,
0.0658666118979454,
0.1108831912279129,
-0.2060312032699585,
0.07815032452344894,
-0.17216378450393677,
0.06113145127892494,
0.10256130248308182,
0.007738585118204355,
0.11218962073326111,
-0.14727434515953064,
-0.18084178864955902,
-0.13225336372852325,
0.23828625679016113,
-0.00914331991225481,
-0.07218288630247116,
0.18304213881492615,
-0.007061264477670193,
-0.16697098314762115,
0.0913013443350792,
0.19946470856666565,
0.0819765031337738,
-0.21993213891983032,
0.013607867993414402,
0.0972585380077362,
0.09338822960853577,
0.11690732836723328,
0.17343640327453613,
0.09519006311893463,
0.09224419295787811,
0.04257042706012726,
0.2735944390296936,
0.12835656106472015,
-0.1501513421535492,
-0.08562494069337845,
-0.012418646365404129,
0.12790459394454956,
-0.24795523285865784,
-0.023366469889879227,
-0.168071448802948,
-0.014260551892220974,
0.1254144161939621,
-0.02191084995865822,
0.20052506029605865,
0.03548436611890793,
-0.3310678005218506,
0.22159810364246368,
0.014409943483769894,
0.2231338769197464,
0.1540493369102478,
-0.09741994738578796,
0.011084078811109066,
0.36736392974853516,
-0.03710997477173805,
0.023191645741462708,
-0.1947862058877945,
-0.0286667812615633,
-0.08159496635198593,
0.12276811897754669,
0.0013288791524246335,
-0.0016218500677496195,
0.02069479040801525,
-0.02239145152270794,
0.0607832707464695,
-0.10502113401889801,
0.13981710374355316,
-0.07664189487695694,
-0.16801312565803528,
0.06471124291419983,
0.048915162682533264,
-0.2408326268196106,
-0.07573433220386505,
-0.2658998966217041,
0.005521789193153381,
0.022468868643045425,
0.13769227266311646,
0.0031994725577533245,
0.22804106771945953,
-0.3525550663471222,
0.038226671516895294,
-0.024168075993657112,
-0.20563919842243195,
-0.2198440581560135,
-0.04813874140381813,
-0.0038158989045768976,
-0.21345503628253937,
-0.007959609851241112,
0.22226040065288544,
-0.08169161528348923,
-0.27146559953689575,
-0.03787698596715927,
0.16023321449756622,
-0.06262586265802383,
0.22224150598049164,
0.14701725542545319,
0.13351723551750183,
-0.09708502888679504,
0.08668157458305359,
-0.017558613792061806,
0.11251191049814224,
0.12977810204029083,
0.1274191290140152,
0.05592014268040657,
-0.06288072466850281,
-0.06874049454927444,
-0.29803189635276794,
0.17442215979099274,
0.014380956068634987,
0.00308877881616354,
-0.02799121104180813,
0.21416136622428894,
0.10351747274398804,
0.02253180555999279,
-0.0008736074669286609,
0.08974188566207886,
-0.3299711346626282,
0.17026837170124054,
0.12064681202173233,
-0.22138825058937073,
0.032076023519039154,
0.1763346940279007,
0.07191577553749084,
0.025073491036891937,
-0.011625758372247219,
0.11056177318096161,
-0.014736371114850044,
0.010046853683888912,
-0.14826273918151855,
0.058622296899557114,
0.09526961296796799,
0.0046549467369914055,
-0.055171288549900055,
0.050247740000486374,
0.14755035936832428,
0.18178632855415344,
-0.06727723777294159,
0.2929575741291046,
-0.09196820110082626,
0.008423914201557636,
0.10487322509288788,
-0.1286594420671463,
-0.18621592223644257,
0.013822591863572598,
-0.016343900933861732,
-0.07086555659770966,
0.040592703968286514,
0.09858357161283493,
0.13811194896697998,
0.09880568087100983,
-0.18568387627601624,
-0.21436290442943573,
0.03244882822036743,
0.09711328148841858,
-0.02660438045859337,
-0.11645881831645966,
0.14233742654323578,
0.007560982368886471,
0.1809931993484497,
0.05715423822402954,
-0.0877411887049675,
-0.14488650858402252,
0.06851015239953995,
0.1692081242799759,
0.13154573738574982,
0.02281981147825718,
0.10082608461380005,
-0.09028485417366028,
0.12448351085186005,
0.0009061761084012687,
0.11909233033657074,
0.08120427280664444,
-0.2964826822280884,
-0.24785229563713074,
-0.0042736646719276905,
-0.0022128806449472904,
0.09721947461366653,
0.062070101499557495,
0.00465118233114481,
0.086698517203331,
0.17327886819839478,
-0.024769548326730728,
0.157728910446167,
0.17374418675899506,
-0.06428220123052597,
0.09993764013051987,
-0.006241710856556892,
-0.06490398198366165,
-0.04061851650476456,
-0.062046218663454056,
0.010656841099262238,
-0.034502290189266205,
0.1404016762971878,
-0.26739701628685,
-0.016721760854125023,
-0.07911531627178192,
-0.2607068121433258,
-0.07691542059183121,
0.01618073135614395,
0.006164838559925556,
0.2138831913471222,
0.13977590203285217,
-0.10096083581447601,
-0.13308294117450714,
-0.1800667941570282,
-0.08235931396484375,
-0.009508000686764717,
-0.09963575005531311,
-0.19542960822582245,
0.2933579385280609,
-0.1074441522359848,
-0.031890079379081726,
-0.19065672159194946,
-0.062494680285453796,
-0.07652296125888824,
0.06825640797615051,
-0.04836668819189072,
0.06486806273460388,
0.3093922436237335,
0.012451798655092716,
-0.002334427088499069,
-0.06777741014957428,
0.10085249692201614,
0.08732873201370239,
0.07038780301809311,
-0.02161419205367565,
-0.023939143866300583,
0.15953460335731506,
0.1180848702788353,
-0.016872694715857506,
0.11035381257534027,
0.19832326471805573,
-0.05569450184702873,
0.04275256395339966,
0.03398878499865532,
0.02453024685382843,
0.045957986265420914,
-0.2616391181945801,
0.13739462196826935,
-0.05698391795158386,
0.14003005623817444,
-0.05451236292719841,
-0.12290370464324951,
-0.15340137481689453,
0.08290361613035202,
-0.1951623409986496,
0.18138349056243896,
-0.014851880259811878,
0.23148857057094574,
-0.12802237272262573,
0.05038744583725929,
-0.013233193196356297,
0.03630123659968376,
-0.013703224249184132,
-0.05719704553484917,
-0.0921744555234909,
0.07819592952728271,
-0.02360822819173336,
-0.045925915241241455,
-0.26618456840515137,
-0.055519141256809235,
-0.06140609830617905,
-0.0989319235086441,
0.09763810783624649,
0.1229555606842041,
-0.2235681116580963,
0.09443787485361099,
-0.07891055941581726,
0.07705986499786377,
0.0039035764057189226,
-0.11047454923391342,
0.13614556193351746,
-0.1231841892004013,
0.014185729436576366,
-0.0564289465546608,
0.12152758240699768,
0.04511602967977524,
0.11014378815889359,
-0.004041907377541065,
0.0994064211845398,
0.014109828509390354,
0.09708522260189056,
-0.004599375184625387,
0.20517267286777496,
-0.0545227974653244,
-0.15290193259716034,
0.13999588787555695,
-0.12015153467655182,
-0.08293256908655167,
0.018758201971650124,
-0.2222786545753479,
-0.01709657348692417,
-0.12636587023735046,
-0.11511152982711792,
-0.16427186131477356,
0.2390112280845642,
0.04421813413500786,
0.008352949284017086,
-0.07994339615106583,
-0.17500364780426025,
0.01608572155237198,
-0.07436570525169373,
-0.04411918297410011,
-0.03509974852204323,
-0.13850057125091553,
-0.09600898623466492,
-0.2467639446258545,
-0.27261680364608765,
-0.0984547808766365,
0.06801244616508484,
0.0729302391409874,
-0.01860899291932583,
-0.19558008015155792,
0.21776512265205383,
0.09431187063455582,
0.10032748430967331,
-0.07436097413301468,
0.019675495103001595,
0.1390192061662674,
0.011280146427452564,
0.212724968791008,
-0.12999440729618073,
-0.022585196420550346,
-0.02141936495900154,
0.17702333629131317,
0.04968886449933052,
0.013637599535286427,
-0.007199369836598635,
0.06929337233304977,
0.03409711644053459,
-0.05168846622109413,
0.22249740362167358,
-0.1655249297618866,
-0.1964111030101776,
0.07091795653104782,
0.06807102262973785,
0.23663553595542908,
-0.21570681035518646,
0.04526227340102196,
0.09309189021587372,
0.1734173744916916,
-0.11288405954837799,
0.03210001066327095,
-0.03312721103429794,
0.1743677854537964,
-0.0650576576590538,
0.08319515734910965,
0.010755483992397785,
0.0680956318974495,
-0.14633792638778687,
0.26369455456733704,
0.1242721825838089,
0.14723291993141174,
-0.3051277995109558,
-0.05942954123020172,
0.060625381767749786,
0.1573902815580368,
0.07368893176317215,
0.05808857083320618,
-0.018146060407161713,
0.038467761129140854,
-0.10911709070205688,
0.038335055112838745,
0.08755102008581161,
-0.2893085777759552,
0.14378750324249268,
0.042708054184913635,
0.11917506158351898,
0.31845301389694214,
0.11132293194532394,
0.0470486655831337,
0.12040919810533524,
0.11052223294973373,
0.17492607235908508,
-0.1871536821126938,
0.27731460332870483,
-0.11202223598957062,
-0.04235352203249931,
-0.22684460878372192,
-0.052863284945487976,
0.1325717568397522,
0.14467522501945496,
-0.29123347997665405,
0.1255418211221695,
0.08748272806406021,
-0.10561255365610123,
-0.009101483039557934,
-0.0019441269105300307,
0.15850402414798737,
-0.10677073150873184,
-0.04851364344358444,
0.02828078716993332,
-0.19427217543125153,
0.02044684812426567,
-0.0826430395245552,
0.12205199152231216,
0.05266725271940231,
-0.020128382369875908,
0.04549027234315872,
-0.10275629162788391,
0.0938800722360611,
0.03816790133714676,
0.010800966061651707,
-0.14409957826137543,
0.00638379342854023,
-0.04946354031562805,
-0.018040655180811882,
-0.1124265044927597,
-0.1446051001548767,
0.1769791543483734,
-0.12250782549381256,
-0.34116336703300476,
0.05398634076118469,
0.023243244737386703,
0.12588395178318024,
0.20958535373210907,
0.017658274620771408,
0.04969562590122223,
0.01682097651064396,
0.054501164704561234,
0.12648293375968933,
-0.013805052265524864,
0.019727647304534912,
0.13022176921367645,
-0.17262257635593414,
-0.09967150539159775,
0.3712780177593231,
0.19681154191493988,
-0.10902819037437439,
0.05196407437324524,
-0.03410997614264488,
-0.09314247220754623,
0.14047519862651825,
0.1688336282968521,
0.18371015787124634,
0.12029387801885605,
0.2710898816585541,
0.021678907796740532,
-0.11609519273042679,
-0.009580601938068867,
0.14864481985569,
0.06660106033086777,
0.05359456688165665,
0.27866309881210327,
0.13845543563365936,
0.16820569336414337,
-0.09031561017036438,
-0.030264025554060936,
-0.12167885899543762,
0.14836449921131134,
0.04343743622303009,
0.2381625920534134,
-0.049974262714385986,
-0.09163051098585129,
0.05182453617453575,
0.13177858293056488,
0.05742267146706581,
0.18212370574474335,
0.09993504732847214,
-0.1261676400899887,
-0.0014347750693559647,
-0.10155530273914337,
-0.16933104395866394,
0.010061567649245262,
-0.1852969527244568,
0.07071620970964432,
-0.13875527679920197,
-0.02983853779733181,
-0.168806254863739,
-0.062216926366090775,
0.23998777568340302,
0.1626541018486023,
-0.1656326800584793,
0.0029871100559830666,
0.008392049930989742,
-0.06291094422340393,
-0.016714714467525482,
0.10534290969371796,
0.002023506909608841,
0.04219647869467735,
-0.0013514152960851789,
-0.09060267359018326,
0.09969786554574966,
-0.01120823435485363,
0.05773995816707611,
0.2164662778377533,
0.07366535067558289,
-0.08888806402683258,
-0.0268893763422966,
0.005729392636567354,
-0.06952296197414398,
0.0007137962966226041,
-0.07225067913532257,
-0.03276257961988449,
-0.05600094795227051,
0.11668015271425247,
-0.11915568262338638,
-0.1229538694024086
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. Neurologic manifestations. Intellectual disability of variable degree has been described in approximately 75% of individuals with prolidase deficiency . Table 3 summarizes IQ scores reported in the medical literature to date.In a review 12 of 30 individuals with molecularly confirmed prolidase deficiency had intellectual disability .In a case series of 12 individuals with prolidase deficiency, one had speech delay, two had mild developmental delay, and six had intellectual disability; three had no delays .In a case series of 20 Druze and Arab Muslims with prolidase deficiency living in northern Israel all had some degree of developmental delay, mainly moderate cognitive or speech delay . More specifically, two had speech delay, eight had mild developmental delay, five had moderate delay, and three had severe delay.Table 3. IQ Scores Reported in Individuals with Prolidase DeficiencyView in own windowIQ ScoreTest UsedReference30NRArata et al 48NROgata et al 52WISC-RFreij et al 52NR | [
-0.025433845818042755,
0.17909756302833557,
0.024339798837900162,
-0.2105288952589035,
0.11918025463819504,
0.0026383984368294477,
-0.037994384765625,
-0.08892548084259033,
-0.05756007879972458,
-0.037868235260248184,
0.10876795649528503,
0.15535087883472443,
0.10780069977045059,
0.02830357849597931,
-0.11008234322071075,
0.004278486128896475,
0.15053631365299225,
-0.06941145658493042,
0.019302066415548325,
0.006711503490805626,
-0.05695611611008644,
-0.01863790675997734,
0.2504647970199585,
0.2180791199207306,
0.10032466053962708,
-0.11689984798431396,
-0.03337865695357323,
0.003931219223886728,
0.06194749474525452,
0.08229223638772964,
-0.0058354767970740795,
-0.028695063665509224,
-0.0949511006474495,
-0.14650239050388336,
0.1679110825061798,
-0.1332913190126419,
-0.11697131395339966,
-0.07533270120620728,
0.1828879863023758,
-0.06188473850488663,
-0.14279639720916748,
0.0170967448502779,
0.122486911714077,
0.05261336639523506,
0.059611476957798004,
-0.062143001705408096,
0.017620805650949478,
0.08173977583646774,
-0.09205614775419235,
0.09316843748092651,
0.1579505056142807,
-0.14549975097179413,
-0.12111036479473114,
-0.0037596102338284254,
0.19442962110042572,
0.20402637124061584,
0.030078882351517677,
0.0683215856552124,
-0.20579999685287476,
0.015024020336568356,
0.1388959139585495,
0.007518131751567125,
-0.13676787912845612,
-0.2585504651069641,
0.2459360659122467,
-0.04145907238125801,
0.10443563759326935,
-0.0973142459988594,
-0.06875088065862656,
-0.14371651411056519,
0.2859150767326355,
-0.06838664412498474,
0.20413096249103546,
0.09958795458078384,
-0.1696753352880478,
0.043269455432891846,
0.11694396287202835,
-0.10756543278694153,
0.06890174746513367,
-0.16679957509040833,
-0.0860816091299057,
0.08118855953216553,
-0.027630183845758438,
0.048825703561306,
0.0467110276222229,
0.28470179438591003,
0.20251159369945526,
0.104624904692173,
0.21635577082633972,
0.02538629062473774,
-0.0039140405133366585,
-0.1525132805109024,
0.027067476883530617,
-0.23842862248420715,
0.0855109915137291,
-0.1337437629699707,
0.04820301756262779,
0.030724475160241127,
-0.13409046828746796,
0.21761693060398102,
0.03828146308660507,
0.0650336965918541,
-0.04242417961359024,
0.114763043820858,
0.10192936658859253,
-0.0397808700799942,
-0.140863299369812,
-0.056633204221725464,
-0.02744671143591404,
-0.03271505609154701,
0.09295877069234848,
-0.014874585904181004,
-0.10523996502161026,
-0.058140501379966736,
-0.07828544825315475,
0.004845708142966032,
0.1434864103794098,
-0.10020039975643158,
-0.09152232110500336,
-0.0597589835524559,
0.05997259542346001,
0.12325419485569,
-0.021389199420809746,
-0.14060638844966888,
0.13767561316490173,
0.14659219980239868,
0.047225549817085266,
0.18154531717300415,
0.2812511622905731,
-0.04575971141457558,
-0.0008090531919151545,
0.2063174545764923,
-0.07076755911111832,
-0.07166457176208496,
-0.05490652844309807,
-0.06863903999328613,
-0.3083275258541107,
-0.16717177629470825,
-0.04126565903425217,
-0.07321436703205109,
0.0548558346927166,
-0.0022691937629133463,
0.10890546441078186,
0.2237512320280075,
-0.01809561625123024,
0.14709113538265228,
0.33034881949424744,
0.05674925446510315,
0.031516268849372864,
0.06719505041837692,
-0.02096395194530487,
-0.06496633589267731,
0.3851252496242523,
-0.004710835870355368,
-0.09231320023536682,
-0.011616519652307034,
-0.026534663513302803,
0.023036204278469086,
-0.12232853472232819,
0.149856835603714,
0.010638650506734848,
-0.08060260862112045,
0.14833392202854156,
-0.011490504257380962,
0.10273907333612442,
-0.06345769017934799,
-0.09316343069076538,
0.08312701433897018,
0.00608590804040432,
0.05981934070587158,
-0.06915228813886642,
0.1928599327802658,
0.011907453648746014,
0.05313273146748543,
0.13954249024391174,
-0.043682266026735306,
-0.07619067281484604,
0.08271615952253342,
-0.05279264971613884,
0.02766098827123642,
0.10955764353275299,
-0.09527166187763214,
-0.18697819113731384,
-0.0008582956506870687,
-0.04420185834169388,
-0.08237309753894806,
0.09842415899038315,
0.2997855246067047,
-0.019083963707089424,
0.1862381398677826,
0.12107505649328232,
0.17754657566547394,
-0.13756026327610016,
-0.059189777821302414,
0.1105501726269722,
-0.08667263388633728,
0.046825096011161804,
-0.037307001650333405,
-0.07979673147201538,
-0.13445664942264557,
0.16607937216758728,
-0.0872778370976448,
0.16431137919425964,
-0.05301342532038689,
-0.12889234721660614,
0.03833700716495514,
0.011380775831639767,
-0.04999955743551254,
-0.1227032020688057,
0.23424296081066132,
0.06733421236276627,
-0.0022434662096202374,
-0.027721349149942398,
0.19766926765441895,
-0.09739238023757935,
-0.028650199994444847,
-0.0749252587556839,
-0.044064123183488846,
-0.0554804652929306,
-0.036908332258462906,
0.013442927040159702,
0.10579909384250641,
-0.02956797182559967,
-0.16345952451229095,
0.07943567633628845,
0.04522211104631424,
-0.08934509754180908,
0.06761989742517471,
-0.031926512718200684,
0.11226516962051392,
-0.0012949879746884108,
0.0444757342338562,
0.05552935600280762,
0.10415284335613251,
-0.14808671176433563,
-0.18926803767681122,
0.045746851712465286,
0.22675612568855286,
0.09087835252285004,
0.06147770583629608,
-0.21103663742542267,
-0.045788947492837906,
0.014282893389463425,
-0.041543085128068924,
-0.08460613340139389,
0.04301358386874199,
-0.11518557369709015,
0.0985320657491684,
-0.06645597517490387,
0.1877286732196808,
-0.1203569769859314,
0.024360911920666695,
0.04116247594356537,
-0.10358045995235443,
-0.39843088388442993,
0.039976783096790314,
0.11610577255487442,
-0.07538382709026337,
0.02128966525197029,
0.09870575368404388,
0.12228716164827347,
0.09541326761245728,
0.12075474858283997,
-0.04337896779179573,
-0.06208647042512894,
-0.04029935225844383,
-0.2534940838813782,
0.003000106895342469,
-0.06127907708287239,
-0.3011050522327423,
-0.038043271750211716,
0.04944884777069092,
0.12376709282398224,
0.15682365000247955,
-0.07526637613773346,
-0.0820411965250969,
-0.13822993636131287,
0.04942018538713455,
0.1263824850320816,
0.0024074367247521877,
-0.039593808352947235,
-0.06707784533500671,
-0.13022029399871826,
-0.0876070111989975,
0.17018727958202362,
0.05404151231050491,
0.12387783080339432,
0.09418494999408722,
-0.10290815681219101,
-0.004951766692101955,
0.12461862713098526,
0.19652141630649567,
-0.18618661165237427,
-0.07426883280277252,
0.016692841425538063,
-0.026177888736128807,
-0.07661554217338562,
0.051599133759737015,
0.08448469638824463,
0.03246046602725983,
0.1981545090675354,
0.009530757553875446,
0.07858240604400635,
0.0355817936360836,
-0.15871860086917877,
-0.014082316309213638,
0.08806030452251434,
0.07961487770080566,
-0.2405344694852829,
0.09756578505039215,
-0.1470540314912796,
-0.10254142433404922,
-0.035946059972047806,
-0.05213984474539757,
0.06817404925823212,
-0.030614493414759636,
-0.3171665668487549,
0.14121586084365845,
0.0438128262758255,
0.12138641625642776,
0.18543830513954163,
0.04420677572488785,
0.1276826709508896,
0.32810962200164795,
-0.110273078083992,
0.0636090561747551,
-0.023653894662857056,
-0.030365196987986565,
0.058793578296899796,
0.11546634137630463,
-0.022682493552565575,
0.057428423315286636,
0.037810295820236206,
-0.11769604682922363,
0.11607068032026291,
0.04926382377743721,
0.27913856506347656,
-0.1482774168252945,
-0.08680925518274307,
-0.005770208779722452,
0.07514560967683792,
-0.09213326871395111,
-0.07522580772638321,
-0.08498679846525192,
-0.19437195360660553,
0.028803402557969093,
-0.03445976972579956,
0.0006612465367652476,
0.0406070202589035,
-0.09227359294891357,
-0.018658701330423355,
0.11008775234222412,
0.07131251692771912,
-0.13057588040828705,
0.1328548640012741,
0.13938221335411072,
-0.11021777242422104,
0.07152404636144638,
0.07078497111797333,
-0.1616198569536209,
-0.24408860504627228,
0.05322038382291794,
0.1878308355808258,
-0.1521477848291397,
0.13793222606182098,
-0.03152008354663849,
0.1455690711736679,
-0.003588045947253704,
0.10810267180204391,
0.024693578481674194,
0.08911962807178497,
-0.016385817900300026,
0.09053436666727066,
0.10170801728963852,
0.056846003979444504,
0.07477272301912308,
-0.20293885469436646,
0.06145142763853073,
-0.09017834067344666,
-0.021198108792304993,
-0.04663752764463425,
0.07135257869958878,
0.1783304363489151,
0.1976774036884308,
0.029339604079723358,
0.11712400615215302,
-0.1653958112001419,
0.11066588014364243,
0.1043475791811943,
-0.2503085136413574,
0.0612974651157856,
0.18623149394989014,
-0.028491947799921036,
0.15685410797595978,
-0.05655230954289436,
0.11328950524330139,
-0.10227026045322418,
-0.0343988873064518,
-0.18041346967220306,
0.14811654388904572,
-0.10789807885885239,
0.01507264468818903,
0.14060470461845398,
0.03648258373141289,
0.11740251630544662,
0.24786365032196045,
0.06031643971800804,
0.21218930184841156,
-0.007726885378360748,
-0.11328240483999252,
0.15070953965187073,
0.04886731877923012,
-0.005481337197124958,
-0.07710985094308853,
-0.03408418968319893,
-0.061685219407081604,
-0.07612735033035278,
0.04677215591073036,
0.05465961620211601,
-0.005370401311665773,
-0.2289978563785553,
-0.18494157493114471,
0.18507732450962067,
0.10946449637413025,
0.01422712579369545,
-0.06991592794656754,
0.16106809675693512,
0.021040430292487144,
0.12054583430290222,
0.15533912181854248,
0.04003305360674858,
0.04949529469013214,
0.012527288869023323,
0.04458501189947128,
0.09444674849510193,
0.06859053671360016,
0.07620636373758316,
0.08955836296081543,
0.1413138061761856,
0.05306626856327057,
0.18087273836135864,
0.06461906433105469,
-0.14802129566669464,
-0.15349632501602173,
-0.2079627364873886,
0.07599788904190063,
0.05365690588951111,
0.09991763532161713,
0.08741945028305054,
0.14590731263160706,
-0.004612650256603956,
-0.01575377769768238,
0.006550971418619156,
-0.09450811892747879,
-0.11015446484088898,
0.24563375115394592,
-0.018910562619566917,
-0.025743115693330765,
-0.11460607498884201,
-0.016216322779655457,
0.10863389074802399,
0.19396069645881653,
-0.00017628319619689137,
-0.23302657902240753,
-0.08075068891048431,
0.0038734753616154194,
-0.0817384123802185,
-0.04885495454072952,
0.10632999241352081,
-0.045237306505441666,
0.15288850665092468,
0.12032616138458252,
-0.10406771302223206,
-0.12270704656839371,
-0.1340055912733078,
-0.09152793884277344,
-0.02545187436044216,
0.11122609674930573,
-0.06754667311906815,
0.1255696713924408,
-0.007712486200034618,
-0.10407306998968124,
-0.19029086828231812,
0.05410999432206154,
-0.08570762723684311,
-0.056614965200424194,
-0.01610199175775051,
-0.014043296687304974,
0.11785443127155304,
0.11416535824537277,
-0.06533057242631912,
0.046970516443252563,
0.025739636272192,
0.18674731254577637,
0.012554026208817959,
-0.276113361120224,
-0.06491722166538239,
-0.08823632448911667,
0.04546939209103584,
-0.10763615369796753,
0.10929037630558014,
0.09910804033279419,
0.061736755073070526,
0.1503143459558487,
0.022075233981013298,
-0.0471564456820488,
0.016246067360043526,
-0.17524529993534088,
0.02441311627626419,
0.18757586181163788,
0.11299224197864532,
-0.03603880852460861,
-0.15409629046916962,
-0.07078764587640762,
-0.02527894452214241,
-0.19374504685401917,
0.15114954113960266,
0.13827857375144958,
0.10723767429590225,
-0.041102997958660126,
0.16079416871070862,
-0.14212863147258759,
0.040348973125219345,
0.031059160828590393,
-0.009657748974859715,
-0.2709093689918518,
0.05987299606204033,
-0.01047567930072546,
-0.2441309690475464,
-0.2465452253818512,
-0.11198090016841888,
0.03856107220053673,
-0.1034257635474205,
0.13885311782360077,
-0.011666443198919296,
-0.04671632498502731,
-0.04892479255795479,
-0.14717736840248108,
-0.005228940863162279,
-0.17287549376487732,
0.0008245359640568495,
0.011345614679157734,
-0.03721151873469353,
0.054727617651224136,
-0.12145581096410751,
0.1058683767914772,
0.08619695156812668,
-0.07077571749687195,
0.09025004506111145,
0.04178273305296898,
-0.06732255220413208,
0.07623903453350067,
0.02536289393901825,
0.13204385340213776,
-0.08913185447454453,
-0.06487541645765305,
0.011891459114849567,
-0.10177161544561386,
-0.0454719141125679,
0.041785698384046555,
-0.15714111924171448,
-0.011220000684261322,
-0.12392808496952057,
-0.06394413858652115,
-0.10080220550298691,
0.1579204499721527,
0.006205760408192873,
-0.004424807615578175,
0.0789700523018837,
-0.10539314895868301,
-0.0854722186923027,
-0.11964574456214905,
-0.03382395580410957,
-0.13445822894573212,
-0.20631933212280273,
0.13976705074310303,
-0.1610473245382309,
-0.17952121794223785,
-0.1531573086977005,
0.14288364350795746,
-0.06708382815122604,
-0.06842856854200363,
-0.010404017753899097,
0.0775337964296341,
0.04936203360557556,
0.13120561838150024,
0.008424283936619759,
-0.07772121578454971,
0.16607020795345306,
-0.06550154089927673,
0.1519540697336197,
-0.06890545040369034,
-0.1713847815990448,
-0.07054907083511353,
0.10352359712123871,
-0.037049852311611176,
0.1384078860282898,
-0.15723691880702972,
0.029660912230610847,
-0.05507146194577217,
-0.08160027861595154,
0.09782900661230087,
-0.10171458125114441,
-0.2135358601808548,
0.05480314791202545,
0.032053835690021515,
0.18255655467510223,
-0.2916906774044037,
0.04538488760590553,
0.10308811813592911,
0.20078569650650024,
-0.09053017199039459,
0.013811750337481499,
-0.0212054755538702,
0.25254136323928833,
0.00037017211434431374,
0.08086604624986649,
-0.022184425964951515,
-0.0003075625281780958,
-0.2507033944129944,
0.13780011236667633,
0.09230635315179825,
0.17893965542316437,
-0.2323969304561615,
-0.03990507498383522,
0.024521617218852043,
0.03546560928225517,
-0.010642413049936295,
0.052147526293992996,
0.17193928360939026,
-0.05642976611852646,
0.02985979989171028,
-0.07220067828893661,
0.11623425781726837,
-0.1406676173210144,
0.0618203803896904,
0.13641755282878876,
0.3053203821182251,
0.09975239634513855,
0.006030896678566933,
-0.029420888051390648,
-0.09949222207069397,
-0.08895004540681839,
0.1972983330488205,
-0.2084933966398239,
0.2006233036518097,
-0.17730578780174255,
-0.009618974290788174,
-0.04773629456758499,
-0.0013664300786331296,
0.143503800034523,
0.016220420598983765,
-0.305036336183548,
0.08454402536153793,
-0.015308331698179245,
0.07086268812417984,
-0.057178229093551636,
-0.03279244899749756,
0.17069365084171295,
-0.13917624950408936,
0.04224254935979843,
0.0711362212896347,
-0.2430400401353836,
0.07206369936466217,
-0.1173643097281456,
0.01925254613161087,
0.0816149041056633,
0.012461554259061813,
0.015327579341828823,
-0.15161128342151642,
0.0557093508541584,
0.15238125622272491,
-0.10456381738185883,
-0.02698032185435295,
-0.015897583216428757,
-0.08226583898067474,
-0.07097221165895462,
-0.14829474687576294,
-0.11961749941110611,
0.16909247636795044,
-0.0718715637922287,
-0.326674222946167,
-0.05675264447927475,
-0.07947084307670593,
-0.008496873080730438,
0.15698586404323578,
0.04025689512491226,
0.013472252525389194,
0.24252597987651825,
-0.008982616476714611,
-0.011681095696985722,
-0.051254212856292725,
0.10313230752944946,
0.14096881449222565,
-0.09180606156587601,
-0.08047811686992645,
0.1977272778749466,
0.10865819454193115,
-0.09250824898481369,
-0.045534901320934296,
-0.06802736222743988,
-0.028226669877767563,
-0.09235882759094238,
0.10353603959083557,
0.06442000716924667,
0.1352664828300476,
0.11476601660251617,
-0.0674736425280571,
-0.1361158937215805,
0.03675052151083946,
-0.07798491418361664,
0.04859157279133797,
0.029959745705127716,
0.018032332882285118,
0.10924743860960007,
0.17066441476345062,
-0.10861880332231522,
0.05266297981142998,
-0.013868624344468117,
-0.012184007093310356,
0.0929308533668518,
-0.07037371397018433,
-0.14214850962162018,
-0.12123178690671921,
0.11205076426267624,
0.08517564088106155,
-0.05325796827673912,
0.134588360786438,
0.1747468262910843,
-0.023793134838342667,
-0.05833936482667923,
-0.09612313657999039,
-0.19163817167282104,
0.0532367080450058,
-0.07189477235078812,
0.036623403429985046,
0.039978913962841034,
-0.03141965717077255,
-0.05412234738469124,
0.029505398124456406,
0.17006054520606995,
0.13404960930347443,
0.02654775232076645,
-0.09166793525218964,
0.08714533597230911,
0.04875592514872551,
-0.13989780843257904,
-0.07316545397043228,
-0.05835395306348801,
0.028425849974155426,
0.16896042227745056,
0.15958759188652039,
0.035306140780448914,
-0.01651958003640175,
-0.06976570188999176,
0.10427490621805191,
0.025900764390826225,
-0.1706141084432602,
0.15993055701255798,
0.037298671901226044,
-0.1467972844839096,
0.014242604374885559,
-0.09691790491342545,
-0.05694739893078804,
-0.05765913054347038,
-0.01938389427959919,
-0.1750539392232895,
-0.09172405302524567
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. e and Arab Muslims with prolidase deficiency living in northern Israel all had some degree of developmental delay, mainly moderate cognitive or speech delay . More specifically, two had speech delay, eight had mild developmental delay, five had moderate delay, and three had severe delay.Table 3. IQ Scores Reported in Individuals with Prolidase DeficiencyView in own windowIQ ScoreTest UsedReference30NRArata et al 48NROgata et al 52WISC-RFreij et al 52NRSekiya et al 55WISC-RMonafo et al 61WISC-RTiller 66NRCleary et al 74WISC-RDunn et al 85WISC-RPowell et al 87Peabody Picture Vocabulary Test, Form BPowell et al 80-90NRGoodman et al NR = not reported; WISC-R = Wechsler Intelligence Scale for Children – RevisedMicrocephaly was described in five | [
-0.03788323327898979,
0.12092890590429306,
0.06109118461608887,
-0.20849378407001495,
0.15660643577575684,
0.02452940121293068,
-0.0520319789648056,
-0.04554861783981323,
-0.08497471362352371,
0.007252873852849007,
0.04840380325913429,
0.21617211401462555,
0.09269366413354874,
0.06011534109711647,
-0.16245579719543457,
0.050477176904678345,
0.13020946085453033,
-0.07803133130073547,
-0.007500459905713797,
-0.006287156604230404,
-0.04350252449512482,
-0.022841621190309525,
0.2661649286746979,
0.18955570459365845,
-0.02452501654624939,
-0.1351943165063858,
-0.028032546862959862,
0.00924152322113514,
0.07917085289955139,
0.08661571145057678,
-0.01515350304543972,
-0.10847488045692444,
-0.012009667232632637,
-0.12327174842357635,
0.10396511107683182,
-0.14531685411930084,
-0.13297957181930542,
-0.06999517977237701,
0.24279306828975677,
-0.041543133556842804,
-0.14558245241641998,
0.05340513214468956,
0.13960015773773193,
0.01615605689585209,
0.08782313019037247,
-0.07092995196580887,
0.01067736279219389,
0.03387703001499176,
0.008559102192521095,
0.036329831928014755,
0.10819244384765625,
-0.20853398740291595,
-0.1611425280570984,
0.014902789145708084,
0.14644494652748108,
0.21271805465221405,
0.0007253176299855113,
0.04488111659884453,
-0.18114066123962402,
0.01685267686843872,
0.22788076102733612,
0.0973634272813797,
-0.1906057894229889,
-0.2142602652311325,
0.23586493730545044,
-0.02751544676721096,
0.07045112550258636,
0.008235259912908077,
-0.012690315954387188,
-0.13498063385486603,
0.23131142556667328,
-0.08308876305818558,
0.1530417948961258,
0.11398813128471375,
-0.16707946360111237,
0.061220794916152954,
0.07227743417024612,
-0.09007009118795395,
0.16362541913986206,
-0.21109212934970856,
-0.029736431315541267,
0.15253551304340363,
0.0015603209612891078,
0.040461353957653046,
0.06935551762580872,
0.2393866926431656,
0.08670269697904587,
0.03725069388747215,
0.187733456492424,
0.00025159813230857253,
-0.0005583108868449926,
-0.14410459995269775,
0.02435894124209881,
-0.2233012169599533,
0.08701090514659882,
-0.0794220045208931,
0.019799115136265755,
0.016544189304113388,
-0.007599502801895142,
0.16212515532970428,
0.05864637717604637,
0.12234315276145935,
-0.08975677937269211,
0.06091747805476189,
0.11404769867658615,
-0.04303578659892082,
-0.17693276703357697,
-0.011486674658954144,
-0.007286019157618284,
-0.03717640042304993,
0.057379480451345444,
-0.03191206604242325,
-0.07116591930389404,
-0.0808289498090744,
-0.044806692749261856,
0.06074017286300659,
0.02273586578667164,
-0.04571056738495827,
-0.09002304077148438,
0.005832545459270477,
0.05905507504940033,
0.09438307583332062,
-0.05824138969182968,
-0.08172336965799332,
0.11588124185800552,
0.1443859338760376,
0.07591011375188828,
0.17714270949363708,
0.19354607164859772,
0.005857109557837248,
-0.011903520673513412,
0.20575912296772003,
-0.0421019122004509,
-0.019771037623286247,
-0.05582878366112709,
-0.03212834149599075,
-0.2311931699514389,
-0.14101117849349976,
0.024496018886566162,
-0.03314768895506859,
0.0662294551730156,
-0.031540993601083755,
0.15501290559768677,
0.19588512182235718,
-0.07313407957553864,
0.18524332344532013,
0.2653421461582184,
0.020110610872507095,
0.04593605175614357,
0.020918656140565872,
-0.024069026112556458,
-0.0618162676692009,
0.3448277711868286,
-0.029602743685245514,
-0.08025319874286652,
-0.06030315160751343,
-0.0093418313190341,
0.09677404910326004,
-0.11107835918664932,
0.1074882447719574,
0.031166953966021538,
-0.028172191232442856,
0.09383166581392288,
-0.07363836467266083,
0.08243640512228012,
0.011219010688364506,
-0.0201403945684433,
0.11869380623102188,
-0.03293007239699364,
0.09606871008872986,
-0.0756353959441185,
0.2424601912498474,
0.04788387566804886,
0.08831702917814255,
0.1557423323392868,
0.05835246667265892,
-0.0628003478050232,
0.0413191132247448,
-0.0677238255739212,
-0.05626856908202171,
0.05147682502865791,
-0.10664740949869156,
-0.18185414373874664,
-0.002314523793756962,
-0.026457529515028,
-0.07201514393091202,
0.13537785410881042,
0.3275315761566162,
-0.06946975737810135,
0.07174888253211975,
0.09678476303815842,
0.18429994583129883,
-0.13655923306941986,
-0.013926096260547638,
0.06347791850566864,
-0.07051829248666763,
0.010907791554927826,
-0.012745958752930164,
-0.01887919194996357,
-0.15303389728069305,
0.2290015071630478,
-0.019614312797784805,
0.12025049328804016,
-0.07517632842063904,
-0.1105816513299942,
-0.021642884239554405,
-0.008017136715352535,
-0.09445901215076447,
-0.0781121477484703,
0.10976265370845795,
0.11338550597429276,
-0.010932285338640213,
-0.0034565215464681387,
0.20759226381778717,
-0.06816225498914719,
-0.08740918338298798,
-0.056599922478199005,
-0.03273296728730202,
-0.06254486739635468,
-0.03236430883407593,
0.05598922073841095,
0.1326783299446106,
-0.07702145725488663,
-0.14421384036540985,
0.06029929965734482,
0.11387573927640915,
-0.15322189033031464,
0.013079259544610977,
-0.08120368421077728,
0.07333355396986008,
0.024184418842196465,
0.03830914944410324,
0.017108945176005363,
0.12648631632328033,
-0.11892514675855637,
-0.2125306874513626,
0.006747916806489229,
0.15664561092853546,
0.051162052899599075,
0.09458263218402863,
-0.08788992464542389,
-0.035395022481679916,
0.02444746345281601,
-0.1130094826221466,
-0.12368427217006683,
0.07458877563476562,
-0.09964016079902649,
0.02437784895300865,
0.0011056343792006373,
0.17369531095027924,
-0.12529322504997253,
0.03631261736154556,
0.00014915649080649018,
-0.08836162090301514,
-0.36359187960624695,
-0.052122563123703,
0.18282805383205414,
-0.028616230934858322,
0.016875460743904114,
0.11628633737564087,
0.12447475641965866,
0.1523064225912094,
0.1291930079460144,
-0.05856962129473686,
-0.18813055753707886,
-0.07546889781951904,
-0.28316524624824524,
0.042297184467315674,
-0.02965603768825531,
-0.27168866991996765,
-0.01913357898592949,
0.006109373643994331,
0.06409061700105667,
0.10950794070959091,
-0.06439251452684402,
-0.09642162173986435,
-0.14343297481536865,
0.03783785179257393,
0.06705915927886963,
0.0434546172618866,
-0.011483093723654747,
-0.08580556511878967,
-0.06043523922562599,
-0.08755206316709518,
0.19032466411590576,
0.038512129336595535,
0.09485671669244766,
0.094849593937397,
-0.08315285295248032,
-0.08862664550542831,
0.12631721794605255,
0.16458256542682648,
-0.13303469121456146,
-0.06675814837217331,
0.05264010280370712,
-0.060770727694034576,
-0.06535293161869049,
0.1409905105829239,
0.07761238515377045,
0.012574974447488785,
0.23565927147865295,
0.010840177536010742,
0.038627736270427704,
0.0011692751431837678,
-0.10742367058992386,
-0.020953988656401634,
0.06719763576984406,
0.05013930797576904,
-0.16660398244857788,
0.03136851266026497,
-0.06531423330307007,
-0.09448590129613876,
0.04583406820893288,
-0.012944971211254597,
0.03608284518122673,
-0.045872077345848083,
-0.2613144516944885,
0.1376989334821701,
0.0025658155791461468,
0.007371881976723671,
0.1804082840681076,
0.0983491986989975,
0.09403868764638901,
0.2983539402484894,
-0.1502845734357834,
0.037774816155433655,
-0.03610457479953766,
-0.03121434524655342,
0.04469015821814537,
0.051251769065856934,
0.027302399277687073,
0.054327525198459625,
-0.03391838073730469,
-0.1256607323884964,
0.101441390812397,
0.04138316586613655,
0.2001636028289795,
-0.10459744185209274,
-0.07554717361927032,
-0.01109875738620758,
0.06878101080656052,
-0.13078007102012634,
-0.08759256452322006,
-0.04201655089855194,
-0.13131392002105713,
0.06325318664312363,
-0.012386079877614975,
-0.037926193326711655,
0.07818592339754105,
-0.09173403680324554,
-0.00513287540525198,
0.11302975565195084,
0.12379753589630127,
-0.09356185793876648,
0.18432559072971344,
0.1438201665878296,
-0.04655078426003456,
0.08125697821378708,
0.033314723521471024,
-0.17537537217140198,
-0.27332183718681335,
0.09438026696443558,
0.12689334154129028,
-0.08001900464296341,
0.14763790369033813,
-0.08860369771718979,
0.029800936579704285,
-0.021690888330340385,
0.11499737203121185,
0.05418909341096878,
0.17004618048667908,
0.04231952503323555,
0.016949322074651718,
0.10693391412496567,
0.1019887924194336,
-0.00671048928052187,
-0.1388578712940216,
0.05157410353422165,
-0.11009669303894043,
-0.041839782148599625,
0.0636618435382843,
0.022312499582767487,
0.1417376846075058,
0.11729589104652405,
0.0309333186596632,
0.11121582984924316,
-0.1577959805727005,
0.04440638795495033,
0.09245222061872482,
-0.19953465461730957,
0.055879440158605576,
0.17334598302841187,
0.038837119936943054,
0.1699460744857788,
0.0052335308864712715,
0.119268998503685,
-0.08884018659591675,
-0.025333808735013008,
-0.15536163747310638,
0.07206874340772629,
-0.08546438813209534,
-0.04363001883029938,
0.10495156049728394,
-0.026576068252325058,
0.13101714849472046,
0.28610384464263916,
0.01638687588274479,
0.21061252057552338,
-0.06409604102373123,
-0.056039318442344666,
0.12597909569740295,
0.05839075520634651,
-0.026647958904504776,
-0.10675564408302307,
-0.02365799993276596,
-0.025051476433873177,
-0.11114538460969925,
-0.011193586513400078,
0.06746743619441986,
-0.046198830008506775,
-0.25555458664894104,
-0.13422799110412598,
0.21814993023872375,
0.12312934547662735,
0.02551374025642872,
-0.03733907639980316,
0.20445343852043152,
0.10508262366056442,
0.08743391931056976,
0.11027465760707855,
0.03364444524049759,
0.005967249628156424,
0.05204980820417404,
0.07139112055301666,
0.0703943744301796,
0.08404410630464554,
0.05439549311995506,
0.022628992795944214,
0.19554519653320312,
0.050410568714141846,
0.17319856584072113,
0.011551027186214924,
-0.09026991575956345,
-0.1027737408876419,
-0.1466900110244751,
0.009038645774126053,
-0.09886730462312698,
-0.028567148372530937,
-0.023227931931614876,
0.07499659806489944,
0.01665372960269451,
-0.015781588852405548,
0.05682661384344101,
-0.03888091444969177,
-0.07863420248031616,
0.22778642177581787,
0.014141784980893135,
-0.038197629153728485,
-0.14551536738872528,
0.036293238401412964,
0.0946136862039566,
0.18330508470535278,
0.042728979140520096,
-0.18686875700950623,
-0.05725467577576637,
-0.0762651115655899,
-0.06835589557886124,
-0.042644619941711426,
0.11429508775472641,
-0.09121772646903992,
0.04746879264712334,
0.06683745980262756,
-0.06434371322393417,
-0.16650953888893127,
-0.15807722508907318,
-0.12389087677001953,
-0.02631523460149765,
0.1530826836824417,
-0.0027445261366665363,
0.11534588783979416,
0.003474926808848977,
-0.14821013808250427,
-0.1824086308479309,
-0.010882162488996983,
-0.10535328835248947,
-0.047678038477897644,
-0.029052946716547012,
-0.03906703740358353,
0.07194606959819794,
0.08116795122623444,
-0.12140040844678879,
0.1006125882267952,
-0.08458571135997772,
0.18308153748512268,
0.04591710492968559,
-0.20494097471237183,
-0.07598266750574112,
0.017873190343379974,
0.013272945769131184,
-0.15603983402252197,
0.17800939083099365,
0.14904934167861938,
0.06356975436210632,
0.026395468041300774,
0.02442323789000511,
-0.008119000121951103,
0.03677316755056381,
-0.1887512356042862,
0.0026959911920130253,
0.040086857974529266,
0.10972324758768082,
0.04525159299373627,
-0.12009766697883606,
-0.06414193660020828,
-0.028087193146348,
-0.08552409708499908,
0.10422453284263611,
0.016196532174944878,
0.05267144739627838,
-0.05045647919178009,
0.1467498540878296,
-0.13238494098186493,
-0.00007400466711260378,
-0.038823701441287994,
0.05124051868915558,
-0.19153980910778046,
0.010349479503929615,
-0.09920235723257065,
-0.207700714468956,
-0.20466665923595428,
-0.0801796093583107,
0.021857772022485733,
-0.07268927246332169,
0.07796627283096313,
0.0099663520231843,
-0.11945488303899765,
-0.02133103273808956,
-0.249461367726326,
-0.002628261921927333,
-0.19040147960186005,
-0.025451336055994034,
-0.026142667979002,
0.014424662105739117,
0.05530970171093941,
-0.08448688685894012,
0.10385986417531967,
0.09851851314306259,
-0.03442808985710144,
0.1367643177509308,
0.06843135505914688,
-0.08004479110240936,
0.03368322178721428,
0.07452783733606339,
0.14929479360580444,
-0.028653044253587723,
-0.0801679790019989,
-0.02863667719066143,
-0.05484237149357796,
0.06787380576133728,
0.08521463721990585,
-0.122478187084198,
-0.020594775676727295,
-0.14616285264492035,
-0.05830066651105881,
-0.04244473949074745,
0.16450229287147522,
0.01934964582324028,
-0.006522792391479015,
0.0633411705493927,
-0.12052206695079803,
-0.026156481355428696,
-0.11408689618110657,
-0.0025836690329015255,
-0.14887522161006927,
-0.1542997509241104,
0.10753333568572998,
-0.09407303482294083,
-0.08311710506677628,
-0.053047072142362595,
0.1395692080259323,
-0.0942380353808403,
-0.013283667154610157,
-0.022580871358513832,
0.04280082508921623,
-0.021768534556031227,
0.10564397275447845,
0.037305086851119995,
-0.07580206543207169,
0.18080632388591766,
-0.06198549270629883,
0.19247406721115112,
-0.04526021331548691,
-0.13906191289424896,
-0.0776098296046257,
0.07640272378921509,
0.001215146272443235,
0.10926004499197006,
-0.14574460685253143,
0.004943995736539364,
-0.03814913332462311,
-0.0724034458398819,
0.043457213789224625,
-0.0753573626279831,
-0.11604718118906021,
0.10222546756267548,
0.014057539403438568,
0.19609622657299042,
-0.25850945711135864,
0.02815861813724041,
0.05078379809856415,
0.13040129840373993,
-0.05978173017501831,
0.01932605355978012,
-0.014216873794794083,
0.23646584153175354,
0.003596503520384431,
0.03595416247844696,
-0.001984029309824109,
-0.017777541652321815,
-0.17522530257701874,
0.09075105935335159,
0.00048285609227605164,
0.18072755634784698,
-0.21341459453105927,
-0.059289898723363876,
0.06608472019433975,
0.034768979996442795,
0.016501642763614655,
0.009564257226884365,
0.15418924391269684,
-0.047931868582963943,
0.0736866146326065,
-0.09231125563383102,
0.07527779787778854,
-0.1389821320772171,
0.04537878930568695,
0.1305951625108719,
0.20041783154010773,
0.12435426563024521,
-0.026252543553709984,
-0.10075323283672333,
-0.14504367113113403,
-0.06208093836903572,
0.17713753879070282,
-0.1685854196548462,
0.12566490471363068,
-0.1199515163898468,
-0.06276404112577438,
-0.05809454992413521,
0.028687002137303352,
0.06534336507320404,
-0.031034644693136215,
-0.14202089607715607,
0.008825364522635937,
-0.06169867888092995,
0.03901001811027527,
-0.010637987405061722,
0.0158841609954834,
0.20702242851257324,
-0.12617768347263336,
0.03586108982563019,
0.15419192612171173,
-0.19921457767486572,
0.18877123296260834,
-0.07845517992973328,
-0.005219482351094484,
0.03371213749051094,
-0.01773858442902565,
0.0706075057387352,
-0.050693053752183914,
-0.06336478143930435,
0.10214028507471085,
-0.031849753111600876,
-0.039481066167354584,
-0.07202349603176117,
-0.03711668774485588,
-0.057344283908605576,
-0.12181196361780167,
-0.12558963894844055,
0.12059483677148819,
-0.059246692806482315,
-0.25653091073036194,
-0.042716193944215775,
-0.033681996166706085,
-0.07099738717079163,
0.1510256826877594,
0.06381023675203323,
-0.0300107691437006,
0.1978568434715271,
0.07519329339265823,
0.004306022543460131,
0.012646236456930637,
0.09973486512899399,
0.06849560886621475,
-0.07330863922834396,
-0.0717710629105568,
0.19904612004756927,
0.13255323469638824,
-0.07390905171632767,
0.011295096017420292,
-0.0751299113035202,
-0.07393490523099899,
-0.09616120904684067,
0.08977798372507095,
0.02352718450129032,
0.15071792900562286,
0.14930923283100128,
-0.062417663633823395,
-0.052258431911468506,
0.06534460932016373,
0.05655856058001518,
0.04705116152763367,
0.07187718898057938,
0.024540014564990997,
0.14113076031208038,
0.10841487348079681,
-0.00474856561049819,
0.1320415735244751,
0.001947061507962644,
0.031359121203422546,
0.05435940623283386,
-0.08478916436433792,
-0.0675663948059082,
-0.15173624455928802,
0.04957432672381401,
-0.005480470601469278,
-0.09122666716575623,
0.17766045033931732,
0.1857478767633438,
-0.044309791177511215,
0.018562491983175278,
-0.051846954971551895,
-0.1352885365486145,
0.0240790918469429,
-0.12366451323032379,
0.05405086278915405,
0.042890869081020355,
-0.10408724099397659,
-0.02546711638569832,
-0.03135710209608078,
0.1375708431005478,
0.09214790910482407,
0.054150231182575226,
-0.1488555371761322,
0.018912311643362045,
0.0004930495051667094,
-0.12423918396234512,
-0.09158584475517273,
-0.0023970480542629957,
0.011363142170011997,
0.11686191707849503,
0.1257065236568451,
0.05699101835489273,
-0.017260398715734482,
-0.06918618083000183,
0.10291296243667603,
-0.005693832412362099,
-0.1609899401664734,
0.0682770162820816,
0.001730427611619234,
-0.10141105204820633,
0.009172781370580196,
-0.11684608459472656,
-0.06835947930812836,
-0.09167598932981491,
-0.03461160883307457,
-0.20933984220027924,
-0.13995040953159332
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. reij et al 52NRSekiya et al 55WISC-RMonafo et al 61WISC-RTiller 66NRCleary et al 74WISC-RDunn et al 85WISC-RPowell et al 87Peabody Picture Vocabulary Test, Form BPowell et al 80-90NRGoodman et al NR = not reported; WISC-R = Wechsler Intelligence Scale for Children – RevisedMicrocephaly was described in five of 11 individuals .Seizures have been described in rare cases .Brain MRI findings include:Multiple microthromboses bilaterally in the cerebral white matter Multiple bilateral subcortical white matter lesions (mainly in the parieto-occipital area), accompanied by leptomeningeal enhancement (one affected individual) Findings compatible with vasculitis Normal (one affected individual) On nerve conduction studies one affected individual had decreased amplitude of motor action potentials and sensory action potentials .Organomegaly. Hepatomegaly and splenomegaly are common | [
-0.045835815370082855,
0.008165845647454262,
-0.045417118817567825,
-0.19574110209941864,
0.2030974179506302,
0.21983438730239868,
-0.11945071816444397,
-0.10511192679405212,
-0.2112882137298584,
-0.04589396342635155,
0.1678348183631897,
0.21515683829784393,
0.1542346328496933,
-0.0011095564113929868,
-0.049968793988227844,
0.059294443577528,
0.19257687032222748,
-0.03863382712006569,
-0.12996622920036316,
0.10210280120372772,
-0.1431848406791687,
-0.09304202347993851,
0.4956189692020416,
0.17871735990047455,
0.06597080826759338,
-0.32516956329345703,
0.07935603708028793,
-0.07563077658414841,
-0.14418412744998932,
0.2239653766155243,
0.04674570634961128,
-0.20453251898288727,
0.14550815522670746,
-0.08452674746513367,
-0.13777998089790344,
-0.1093171164393425,
-0.11123398691415787,
-0.09613382071256638,
0.34797680377960205,
-0.026501914486289024,
-0.17185078561306,
0.13951337337493896,
0.250868558883667,
0.143182635307312,
0.02143613062798977,
-0.33158889412879944,
-0.0022064542863518,
-0.03185061365365982,
-0.1434522420167923,
0.14886505901813507,
0.26281464099884033,
-0.06529483199119568,
-0.13614626228809357,
0.03305663540959358,
0.11967494338750839,
0.1314752846956253,
-0.006873875390738249,
0.2275998294353485,
-0.05393431335687637,
0.23156419396400452,
0.008129478432238102,
-0.03094560094177723,
-0.07915419340133667,
-0.37000522017478943,
0.30109843611717224,
-0.010173306800425053,
0.13738034665584564,
0.022806702181696892,
0.0027409528847783804,
-0.14241734147071838,
0.2700604796409607,
0.07281035929918289,
-0.00958495307713747,
0.09753142297267914,
-0.12612469494342804,
0.03457861393690109,
0.024864323437213898,
-0.010777835734188557,
0.06170268729329109,
-0.14342112839221954,
-0.04438570514321327,
0.1312793493270874,
-0.23143327236175537,
0.19022919237613678,
-0.02525470033288002,
0.2221633344888687,
0.13498908281326294,
-0.08825176954269409,
0.19556966423988342,
-0.007364335935562849,
-0.02173084393143654,
-0.04409082978963852,
0.0450320802628994,
-0.10597839951515198,
-0.07743969559669495,
-0.0057390970177948475,
-0.07705047726631165,
0.019708560779690742,
0.08315397053956985,
-0.02754424698650837,
0.016634942963719368,
0.23222693800926208,
-0.11568872630596161,
0.16351564228534698,
0.16415473818778992,
-0.25607749819755554,
-0.14635510742664337,
-0.008266854099929333,
-0.10115379095077515,
0.006925768684595823,
0.06400483101606369,
-0.02045602537691593,
-0.044406794011592865,
-0.040096595883369446,
-0.1384277045726776,
-0.09407929331064224,
-0.00016770049114711583,
0.019561467692255974,
-0.1335340142250061,
-0.10075908154249191,
-0.0640510618686676,
0.03870920091867447,
-0.06780782341957092,
0.04269765317440033,
0.21234363317489624,
0.03483332321047783,
0.11728929728269577,
0.08038382232189178,
0.2573769688606262,
0.09757476300001144,
-0.06800246238708496,
0.02058723010122776,
-0.05033126473426819,
-0.10408757627010345,
-0.1610427051782608,
-0.029521184042096138,
-0.22076208889484406,
-0.035362180322408676,
0.0779421478509903,
-0.26261216402053833,
-0.022490980103611946,
-0.17560291290283203,
0.0798216313123703,
0.25824639201164246,
-0.05274314805865288,
0.15434898436069489,
0.43852290511131287,
0.09539433568716049,
0.0869460180401802,
0.08981000632047653,
0.03686242178082466,
-0.10177069157361984,
0.5507445335388184,
-0.005124986637383699,
-0.23464429378509521,
0.12013246864080429,
-0.08595391362905502,
-0.0021237109322100878,
-0.17748527228832245,
0.12929493188858032,
0.2055639624595642,
0.04473843798041344,
-0.03170542046427727,
-0.11564475297927856,
0.12447527796030045,
0.027945566922426224,
-0.04078676551580429,
-0.13340775668621063,
0.29188334941864014,
0.15681971609592438,
-0.1133989542722702,
0.039128709584474564,
-0.1275254189968109,
0.10841004550457001,
0.15735551714897156,
-0.10443367809057236,
-0.021283172070980072,
0.11209302395582199,
-0.09522313624620438,
-0.13130523264408112,
-0.23654459416866302,
-0.10847293585538864,
-0.22574767470359802,
0.07610715180635452,
0.09044215828180313,
-0.24326935410499573,
0.1600807011127472,
0.06475185602903366,
-0.012258202768862247,
0.06116696447134018,
0.05521463602781296,
0.1161862462759018,
-0.12830811738967896,
-0.12726990878582,
-0.10573985427618027,
-0.15961651504039764,
-0.033680837601423264,
0.07426763325929642,
0.027100704610347748,
-0.1181069016456604,
0.2001064121723175,
-0.12839442491531372,
0.08995691686868668,
-0.12362740188837051,
0.055124469101428986,
0.1926417201757431,
-0.14544065296649933,
0.11899644881486893,
-0.17503027617931366,
0.16836534440517426,
0.07800290733575821,
0.04867778345942497,
0.08824215084314346,
0.22485047578811646,
-0.09559532254934311,
0.05149276182055473,
-0.23868878185749054,
-0.13297507166862488,
0.047064390033483505,
0.04642282798886299,
0.1049358919262886,
0.10935987532138824,
0.11919161677360535,
-0.23117850720882416,
-0.19370442628860474,
0.018448399379849434,
-0.16700124740600586,
0.036946363747119904,
-0.014780446887016296,
-0.059200238436460495,
-0.18539853394031525,
-0.030918700620532036,
0.09262740612030029,
0.06131990626454353,
-0.03875545412302017,
-0.19987085461616516,
0.0642986074090004,
0.24505165219306946,
0.13814228773117065,
0.008720170706510544,
-0.2210536152124405,
0.0792539119720459,
0.04202495515346527,
-0.1324220448732376,
-0.2689436078071594,
0.0663091316819191,
-0.19217824935913086,
0.10540590435266495,
0.05881432071328163,
0.2992965281009674,
-0.14044269919395447,
0.11545325070619583,
0.0199241004884243,
-0.023007811978459358,
-0.3556618392467499,
0.026210783049464226,
0.16026288270950317,
-0.12664557993412018,
0.11378702521324158,
0.15184195339679718,
0.09708511829376221,
0.040024206042289734,
-0.13487373292446136,
0.07306886464357376,
-0.05002716928720474,
-0.11610892415046692,
-0.09714830666780472,
0.12871596217155457,
-0.08542367070913315,
-0.3289685845375061,
-0.11038357019424438,
0.12007464468479156,
0.12079286575317383,
0.04824637621641159,
-0.22467151284217834,
-0.10875505208969116,
-0.03801741823554039,
0.040081143379211426,
0.23388540744781494,
-0.009074440225958824,
-0.1439935564994812,
-0.16574066877365112,
-0.07644511014223099,
0.07429546862840652,
0.3553842008113861,
0.10891326516866684,
0.016835473477840424,
0.024696340784430504,
0.00207759952172637,
-0.07806289941072464,
-0.05238690227270126,
0.24399897456169128,
-0.21126562356948853,
-0.13026127219200134,
0.15750731527805328,
0.0026518648955971003,
-0.007078236900269985,
-0.08798082172870636,
0.020547207444906235,
0.1083676740527153,
0.1607021689414978,
0.0724530816078186,
-0.03115733526647091,
0.03674452006816864,
-0.2269061803817749,
0.021234197542071342,
0.21771687269210815,
0.1662696748971939,
-0.11237666010856628,
0.14196895062923431,
-0.16125300526618958,
-0.031469058245420456,
0.160514235496521,
-0.2851361036300659,
-0.054700326174497604,
0.020207468420267105,
-0.1843070387840271,
0.021729543805122375,
0.15778109431266785,
0.16057263314723969,
0.3339284360408783,
-0.1748918890953064,
0.09829821437597275,
0.3493858277797699,
0.07363029569387436,
0.07126209139823914,
-0.18883085250854492,
0.09474792331457138,
0.11358606815338135,
-0.008599935099482536,
0.03671298921108246,
-0.018941020593047142,
-0.025346504524350166,
-0.11254795640707016,
0.15322840213775635,
0.03325176611542702,
0.2613740861415863,
-0.10107880085706711,
-0.04827207699418068,
-0.026540430262684822,
0.014633622951805592,
0.05493539571762085,
-0.09753778576850891,
-0.07325208187103271,
-0.06083695590496063,
0.05043633282184601,
-0.03619171306490898,
-0.008608999662101269,
0.24196024239063263,
0.026529831811785698,
-0.14852561056613922,
-0.11498697847127914,
0.023035630583763123,
-0.14096713066101074,
0.08900364488363266,
0.08979138731956482,
0.10130488872528076,
0.0058183688670396805,
0.1785881370306015,
-0.23124556243419647,
-0.19019290804862976,
0.09798986464738846,
0.2607763707637787,
-0.12225273251533508,
0.15998926758766174,
-0.05293024703860283,
0.07917334139347076,
0.15743353962898254,
0.0912565365433693,
-0.007564714178442955,
0.109093576669693,
0.03292160853743553,
0.15593397617340088,
0.07528002560138702,
0.14808116853237152,
-0.05272205173969269,
-0.3537145256996155,
0.1766146719455719,
-0.05005335435271263,
0.029281066730618477,
-0.03278316184878349,
0.14177528023719788,
-0.04095711559057236,
0.23587463796138763,
0.07202982157468796,
0.17340382933616638,
-0.16638575494289398,
0.18044303357601166,
0.14297594130039215,
-0.29632776975631714,
0.10237271338701248,
0.2179485261440277,
-0.06885399669408798,
0.22094590961933136,
-0.09927280247211456,
0.05803617835044861,
-0.03084264136850834,
-0.10416457056999207,
-0.07446188479661942,
0.05740083009004593,
-0.10179992020130157,
-0.02939685992896557,
0.22855934500694275,
0.005095848813652992,
0.11322802305221558,
0.2653719186782837,
-0.016812393441796303,
0.3159539997577667,
-0.010265869088470936,
-0.1006467267870903,
0.009862731210887432,
-0.04870406165719032,
-0.22769339382648468,
-0.11373135447502136,
-0.02751670777797699,
-0.01800456829369068,
-0.08129085600376129,
0.059017207473516464,
0.2817397713661194,
-0.09074870496988297,
-0.3878057301044464,
-0.22151459753513336,
0.1502920538187027,
-0.07442401349544525,
-0.12569908797740936,
-0.004070970695465803,
0.13874323666095734,
-0.05910416319966316,
0.2394016832113266,
0.14919447898864746,
0.2570524215698242,
0.10882055759429932,
-0.12770956754684448,
0.05859104543924332,
0.190291166305542,
0.020923633128404617,
0.13162508606910706,
0.08231739699840546,
0.1910841017961502,
-0.026406580582261086,
0.08739390969276428,
0.2833283245563507,
-0.16659702360630035,
-0.1725246161222458,
-0.021747412160038948,
0.06610742211341858,
0.039050377905368805,
-0.04304758459329605,
-0.11608318984508514,
0.06628210097551346,
0.10232800990343094,
-0.02755296602845192,
0.07789984345436096,
-0.09060540795326233,
-0.11462035030126572,
0.07233230024576187,
-0.11130815744400024,
-0.11867064982652664,
-0.2124701738357544,
0.014940810389816761,
-0.11318602412939072,
-0.04036543890833855,
0.08115698397159576,
-0.017351847141981125,
0.16622282564640045,
0.21279747784137726,
-0.07549082487821579,
-0.187625452876091,
-0.00029445078689605,
0.015981372445821762,
0.27266010642051697,
0.14507544040679932,
-0.05400853231549263,
-0.11881842464208603,
-0.007459614891558886,
-0.05638973042368889,
-0.08711795508861542,
0.13373205065727234,
-0.14560572803020477,
0.13352681696414948,
-0.10308066010475159,
0.05503291264176369,
-0.1978268027305603,
0.14777730405330658,
-0.032177843153476715,
0.00974345114082098,
-0.12311004102230072,
0.0457022488117218,
0.28457963466644287,
0.11975932866334915,
0.11504457890987396,
0.047563496977090836,
0.04179215431213379,
0.3681853115558624,
0.1354399174451828,
-0.1649688184261322,
-0.007156312465667725,
-0.19113165140151978,
0.09924701601266861,
-0.09878040850162506,
0.1268913745880127,
0.016353826969861984,
0.005186576396226883,
0.011628050357103348,
-0.08735101670026779,
-0.04398158937692642,
-0.054954495280981064,
-0.14781233668327332,
-0.010740227065980434,
0.14069707691669464,
0.16275034844875336,
-0.1582939624786377,
-0.10318437963724136,
-0.12442243844270706,
0.12296958267688751,
-0.32195034623146057,
0.24041835963726044,
0.21038644015789032,
0.15812505781650543,
0.02152310311794281,
0.12515541911125183,
-0.08049818873405457,
-0.14185726642608643,
-0.011465311050415039,
0.006686889100819826,
-0.3576792776584625,
0.04838147014379501,
-0.06357370316982269,
-0.24672859907150269,
-0.10762135684490204,
-0.24374525249004364,
-0.08749262243509293,
-0.20308126509189606,
0.08970530331134796,
0.11931946128606796,
-0.14806075394153595,
-0.10661089420318604,
-0.038519345223903656,
0.13502617180347443,
-0.05977017432451248,
-0.02110585756599903,
0.1396694779396057,
-0.08821787685155869,
-0.000004772135980601888,
-0.02218157798051834,
0.061227791011333466,
0.10109488666057587,
-0.03426108881831169,
0.15876193344593048,
0.005448140669614077,
-0.0735974833369255,
0.024713514372706413,
0.0313185378909111,
0.0718584954738617,
-0.05441395565867424,
0.014374934136867523,
0.03706672415137291,
-0.1408650130033493,
-0.17595773935317993,
0.06974053382873535,
-0.062162261456251144,
-0.1913018524646759,
-0.12482036650180817,
0.009805645793676376,
-0.1027485579252243,
0.13920383155345917,
-0.17709723114967346,
-0.004086258355528116,
0.0025972877629101276,
-0.1362333595752716,
-0.034389104694128036,
0.012891940772533417,
-0.020842349156737328,
-0.22838477790355682,
-0.19606292247772217,
-0.022157805040478706,
-0.24823293089866638,
-0.0830712541937828,
0.019009718671441078,
0.08115153014659882,
-0.23413294553756714,
-0.11562173068523407,
0.09660018980503082,
0.23354895412921906,
0.11939477175474167,
0.26932498812675476,
0.07574281096458435,
-0.1349014788866043,
0.10170869529247284,
-0.1069815382361412,
0.14511846005916595,
-0.1964014768600464,
-0.1099468544125557,
0.06779726594686508,
0.000694681191816926,
0.06587451696395874,
0.08799298852682114,
-0.21101093292236328,
-0.16242715716362,
-0.002730435226112604,
-0.10662489384412766,
0.10617761313915253,
-0.06796925514936447,
-0.08419465273618698,
0.06251140683889389,
0.05588411167263985,
0.26742833852767944,
-0.22872371971607208,
0.18351174890995026,
0.05966109782457352,
0.10823928564786911,
-0.1173822209239006,
0.1542878895998001,
-0.08607883751392365,
0.20735220611095428,
-0.04083811864256859,
0.07929801940917969,
-0.09447301924228668,
-0.10284512490034103,
-0.2591782808303833,
0.20264576375484467,
0.15500780940055847,
0.1922275424003601,
-0.22644959390163422,
-0.09310157597064972,
0.08551125973463058,
0.1186010092496872,
0.0339348241686821,
0.09378562122583389,
0.11777601391077042,
-0.22508858144283295,
0.017421722412109375,
-0.12477441132068634,
0.11721721291542053,
-0.1017773225903511,
0.0452534556388855,
0.06891327351331711,
0.3742627501487732,
0.028142033144831657,
-0.09757623821496964,
-0.2657497823238373,
0.013345821760594845,
0.04189349338412285,
0.20317983627319336,
-0.14807778596878052,
0.12235739082098007,
-0.08581851422786713,
-0.09951414912939072,
-0.11875321716070175,
-0.09334200620651245,
0.06597263365983963,
0.11929802596569061,
-0.10652832686901093,
0.16085809469223022,
-0.18140853941440582,
-0.0011129457270726562,
-0.040614522993564606,
-0.06479213386774063,
0.04784359037876129,
-0.03938141092658043,
-0.09301826357841492,
-0.039358481764793396,
0.08548048138618469,
0.18410281836986542,
0.1249024048447609,
-0.16941414773464203,
0.08530221879482269,
-0.059381917119026184,
0.07370387762784958,
-0.15124332904815674,
0.10803033411502838,
0.09720910340547562,
-0.06937272846698761,
-0.07976207882165909,
0.017897317185997963,
-0.09472730755805969,
-0.13403521478176117,
-0.024852560833096504,
-0.009881543926894665,
0.20617204904556274,
0.020248377695679665,
-0.28655797243118286,
-0.031133556738495827,
0.08462461084127426,
0.21218711137771606,
0.1985345184803009,
0.06544779241085052,
0.22500582039356232,
0.2161845713853836,
0.028842052444815636,
-0.04513450339436531,
-0.12369877845048904,
0.07122683525085449,
0.17500658333301544,
-0.2355576753616333,
-0.13869665563106537,
0.05398988351225853,
0.11362048238515854,
0.05252423882484436,
0.03873230889439583,
-0.11341733485460281,
-0.10233452916145325,
0.05788039788603783,
0.03395882248878479,
0.03063349239528179,
0.06343620270490646,
0.1824507713317871,
-0.0543435737490654,
-0.07234515994787216,
0.008133511058986187,
0.035573769360780716,
-0.11409549415111542,
-0.08048620074987411,
0.3225749135017395,
-0.0789157897233963,
0.10887570679187775,
-0.08848980069160461,
0.0124506251886487,
-0.01897239312529564,
0.12167336046695709,
0.08153577893972397,
0.100716233253479,
0.06397612392902374,
-0.015632005408406258,
0.008479604497551918,
-0.001333676278591156,
-0.2654820382595062,
0.19260449707508087,
0.2044139951467514,
0.11299378424882889,
-0.16410942375659943,
-0.1804412454366684,
-0.12260644137859344,
0.17636071145534515,
-0.11333581060171127,
0.05172107368707657,
-0.06829668581485748,
-0.025032173842191696,
0.03177819028496742,
0.1507028192281723,
-0.09442877769470215,
0.2567867338657379,
0.004955929704010487,
-0.011533080600202084,
0.06320850551128387,
0.01706678792834282,
-0.00008592686936026439,
0.039844922721385956,
-0.09670530259609222,
-0.1660013347864151,
0.003395373933017254,
0.18801701068878174,
0.1399117410182953,
0.0390855111181736,
0.0727643370628357,
0.07030277699232101,
0.04239564388990402,
-0.1945372223854065,
-0.17633746564388275,
-0.0016259091207757592,
-0.2729780077934265,
0.09639076888561249,
-0.10153082013130188,
0.08039537072181702,
0.1313565969467163,
-0.048897963017225266,
-0.11013265699148178,
-0.06159275025129318
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. ephaly was described in five of 11 individuals .Seizures have been described in rare cases .Brain MRI findings include:Multiple microthromboses bilaterally in the cerebral white matter Multiple bilateral subcortical white matter lesions (mainly in the parieto-occipital area), accompanied by leptomeningeal enhancement (one affected individual) Findings compatible with vasculitis Normal (one affected individual) On nerve conduction studies one affected individual had decreased amplitude of motor action potentials and sensory action potentials .Organomegaly. Hepatomegaly and splenomegaly are common and variable in severity; in one instance massive splenomegaly (spleen measuring 35 cm) has been reported .Liver enzymes may be mildly elevated .Hematologic manifestations. Anemia can be either mild microcytic hypochromic anemia or normocytic normochromic anemia .Hemolysis has been described , with reticulocytosis varying from 5.9% to 8.6% .Thrombocytopenia is fairly common .Immunologic manifestations. Recurrent episodes of otitis media, sinusitis, pneumonia, and gastroenteritis are common .Elevated levels of | [
0.03453928232192993,
0.06145109608769417,
-0.04630206525325775,
-0.20986123383045197,
0.22156158089637756,
0.14723898470401764,
0.02848469279706478,
-0.10438675433397293,
-0.14764170348644257,
-0.1223335713148117,
0.14504584670066833,
0.21167929470539093,
0.14540761709213257,
0.13830457627773285,
-0.044527821242809296,
0.059901829808950424,
0.15068939328193665,
-0.027877043932676315,
-0.0874212458729744,
0.14245565235614777,
-0.1757981926202774,
-0.021151786670088768,
0.3983510136604309,
0.08285755664110184,
0.21973861753940582,
-0.2767828702926636,
-0.0010845999931916595,
-0.06207277625799179,
-0.15508024394512177,
0.22344250977039337,
0.10598935931921005,
-0.20674951374530792,
0.017474794760346413,
-0.09258159250020981,
-0.025333844125270844,
-0.07365699857473373,
-0.0889020562171936,
-0.2096700817346573,
0.3631475269794464,
-0.050211042165756226,
-0.22780928015708923,
0.03766302391886711,
0.3039858937263489,
0.07167597115039825,
0.0024522910825908184,
-0.2509795129299164,
-0.09843040257692337,
0.009345727041363716,
-0.17371906340122223,
0.17047986388206482,
0.3330846428871155,
-0.03185337781906128,
-0.14270637929439545,
0.02855871431529522,
0.14209814369678497,
0.07637910544872284,
0.07157310843467712,
0.22718623280525208,
-0.002403492107987404,
0.15819606184959412,
-0.045736998319625854,
-0.056334175169467926,
-0.0827670469880104,
-0.4096951186656952,
0.29475268721580505,
-0.07404197752475739,
0.11971496045589447,
-0.08782553672790527,
-0.07410117238759995,
-0.12243860214948654,
0.3304169178009033,
0.12575294077396393,
0.09951263666152954,
0.08763696998357773,
-0.15213893353939056,
0.11121924221515656,
-0.0015005122404545546,
-0.064748615026474,
0.012032837606966496,
-0.14506764709949493,
-0.14546169340610504,
0.13255514204502106,
-0.2673892676830292,
0.14715605974197388,
-0.05280149728059769,
0.3089997172355652,
0.1089465543627739,
-0.10612233728170395,
0.27360251545906067,
0.08332911878824234,
-0.1646358072757721,
-0.12322145700454712,
0.13925713300704956,
-0.1896311193704605,
-0.13925278186798096,
-0.04034408554434776,
0.004069337621331215,
0.028012804687023163,
0.0953570306301117,
-0.04149295762181282,
-0.04753408581018448,
0.14884015917778015,
-0.0038732357788830996,
0.24673248827457428,
0.07992184907197952,
-0.17491649091243744,
-0.09868502616882324,
0.0251174196600914,
-0.1950821429491043,
0.09261034429073334,
0.16925787925720215,
0.03798159211874008,
-0.1853794902563095,
-0.016584744676947594,
-0.19831056892871857,
0.015271026641130447,
-0.00037896796129643917,
0.029622089117765427,
-0.1414899080991745,
-0.09407920390367508,
-0.0016935871681198478,
0.07799307256937027,
-0.04658160358667374,
0.055818453431129456,
0.22484427690505981,
0.05579660087823868,
0.03206783905625343,
0.014232590794563293,
0.2998647689819336,
0.05426754429936409,
-0.028935201466083527,
-0.017546119168400764,
0.001823960104957223,
-0.26039206981658936,
-0.17704959213733673,
0.028196046128869057,
-0.18716511130332947,
-0.1257897913455963,
0.002453580731526017,
-0.2758658230304718,
-0.0693974420428276,
-0.0778527557849884,
0.13043208420276642,
0.27110156416893005,
0.07842753827571869,
0.1366787999868393,
0.4633484184741974,
0.12146680057048798,
-0.011467674747109413,
0.024470385164022446,
0.06316788494586945,
-0.1906338483095169,
0.4795529544353485,
-0.019124502316117287,
-0.24791152775287628,
0.15944397449493408,
-0.1224106103181839,
0.0026376736350357533,
-0.23159433901309967,
0.1203136295080185,
0.17883437871932983,
0.04063814878463745,
0.06702467054128647,
-0.11481577903032303,
0.12041569501161575,
0.00633504381403327,
-0.011486205272376537,
-0.1800236701965332,
0.20744074881076813,
0.06683885306119919,
-0.09608432650566101,
0.03827216848731041,
-0.0949992761015892,
0.08376457542181015,
0.20923958718776703,
-0.11719639599323273,
-0.02905929833650589,
0.1597999930381775,
-0.095645472407341,
-0.15788528323173523,
-0.16733799874782562,
-0.11780556291341782,
-0.2171473205089569,
-0.06642532348632812,
0.034578680992126465,
-0.2684532701969147,
0.0064731743186712265,
0.05160607770085335,
0.0652179941534996,
0.05015861988067627,
0.11518983542919159,
0.03974909707903862,
-0.051939066499471664,
-0.11167648434638977,
-0.1576782763004303,
-0.16047130525112152,
-0.015765506774187088,
0.03660105913877487,
-0.050092823803424835,
-0.0824183002114296,
0.18413953483104706,
-0.21150632202625275,
0.16924016177654266,
-0.08869802951812744,
0.031798105686903,
0.16550594568252563,
-0.08309171348810196,
0.24122625589370728,
-0.17618004977703094,
0.32252684235572815,
0.12040794640779495,
0.0882030576467514,
0.04416721314191818,
0.23077264428138733,
-0.10724794119596481,
-0.016630781814455986,
-0.2613092362880707,
-0.09922721982002258,
0.0021055855322629213,
0.041612476110458374,
0.028394894674420357,
0.020199261605739594,
0.16029715538024902,
-0.291189581155777,
-0.23221193253993988,
-0.017272690311074257,
-0.1240941733121872,
0.0639788806438446,
-0.04459965601563454,
0.01910397596657276,
-0.16416588425636292,
0.07908549159765244,
0.08122523128986359,
0.03473646938800812,
-0.02966531738638878,
-0.17425550520420074,
0.11055747419595718,
0.3714378774166107,
0.10929138958454132,
-0.048554856330156326,
-0.3414181172847748,
0.0521012544631958,
0.04669146612286568,
-0.0976518914103508,
-0.2852548360824585,
0.12866544723510742,
-0.17094816267490387,
0.09257736802101135,
0.0060200379230082035,
0.20061688125133514,
-0.09208321571350098,
0.156997948884964,
0.010759915225207806,
-0.07874108105897903,
-0.3239120543003082,
0.08698161691427231,
0.23262447118759155,
-0.03143381327390671,
0.08978819102048874,
0.07632367312908173,
0.09493459016084671,
0.042951133102178574,
-0.16179923713207245,
0.07719018310308456,
0.01976994425058365,
-0.055780962109565735,
-0.10715882480144501,
0.07067323476076126,
-0.12851981818675995,
-0.31661948561668396,
-0.03249571844935417,
0.21064980328083038,
0.08446625620126724,
0.0903930515050888,
-0.17083822190761566,
-0.10069260746240616,
-0.12530848383903503,
-0.017410719767212868,
0.33877384662628174,
0.07704751938581467,
-0.17410306632518768,
-0.1821030080318451,
-0.15149833261966705,
0.06955002248287201,
0.3071591258049011,
0.06814788281917572,
0.0031621893867850304,
0.08680504560470581,
0.01349733304232359,
-0.03786548599600792,
-0.067933589220047,
0.27431926131248474,
-0.09160353988409042,
-0.015626488253474236,
0.22744442522525787,
0.03202694654464722,
-0.03496549278497696,
-0.015155035071074963,
0.12422442436218262,
0.12436696887016296,
0.14221705496311188,
0.13595958054065704,
0.023592066019773483,
0.034811560064554214,
-0.2681897282600403,
-0.00044753775000572205,
0.20277287065982819,
0.21861203014850616,
-0.1860637664794922,
0.2567801773548126,
-0.21328742802143097,
-0.066053606569767,
0.03451664745807648,
-0.17600050568580627,
-0.06374985724687576,
0.01919259876012802,
-0.17488956451416016,
0.09578666090965271,
0.23311205208301544,
0.21597115695476532,
0.30271416902542114,
-0.2008299082517624,
0.16903892159461975,
0.3226298987865448,
0.010881070047616959,
0.08151716738939285,
-0.2031593918800354,
0.05710367485880852,
0.08688661456108093,
0.054692335426807404,
0.043360427021980286,
0.014120122417807579,
0.06000886112451553,
-0.028165027499198914,
0.18960893154144287,
-0.002214856445789337,
0.31737565994262695,
-0.06078321486711502,
-0.0794195607304573,
-0.11750315874814987,
-0.06551752239465714,
0.10211871564388275,
0.02672969549894333,
-0.17544135451316833,
-0.0847444161772728,
-0.06576865166425705,
-0.010675641708076,
0.12693701684474945,
0.2595112919807434,
-0.06257601827383041,
-0.1562815010547638,
0.07060571014881134,
-0.1319911628961563,
-0.10472171008586884,
0.07993245124816895,
0.0044201212003827095,
-0.013045929372310638,
0.0821206122636795,
0.24135877192020416,
-0.19224952161312103,
-0.20033808052539825,
0.10152746737003326,
0.36421072483062744,
-0.18230606615543365,
0.14511558413505554,
0.0668359100818634,
0.14875254034996033,
0.09245274215936661,
-0.004338215105235577,
-0.08978769928216934,
0.08616538345813751,
-0.004564974457025528,
0.28571510314941406,
0.021703924983739853,
0.16421082615852356,
-0.03274243324995041,
-0.44525304436683655,
0.24503137171268463,
-0.05684316158294678,
0.060995087027549744,
-0.21403299272060394,
0.20228029787540436,
0.01381071750074625,
0.23497043550014496,
0.17040641605854034,
0.1971646547317505,
-0.15003691613674164,
0.20424899458885193,
0.13294647634029388,
-0.311227023601532,
0.12418859452009201,
0.2834981381893158,
-0.02630010060966015,
0.18680205941200256,
-0.09338665008544922,
0.02882710099220276,
-0.03022320196032524,
0.011403806507587433,
-0.10056115686893463,
0.037147317081689835,
-0.13256646692752838,
-0.009127086959779263,
0.29233625531196594,
-0.01755807176232338,
0.13685552775859833,
0.10914769768714905,
-0.024457469582557678,
0.30875951051712036,
-0.027384918183088303,
-0.14039672911167145,
-0.027425168082118034,
-0.12399794161319733,
-0.12436338514089584,
-0.09565185755491257,
0.1005418449640274,
-0.05439741536974907,
-0.1261254847049713,
-0.0032704127952456474,
0.3201422691345215,
0.025558313354849815,
-0.3285152018070221,
-0.31072452664375305,
0.13115191459655762,
-0.09954170882701874,
-0.1487162709236145,
-0.012964468449354172,
0.1413927525281906,
-0.11273662745952606,
0.19669319689273834,
0.03989894688129425,
0.16988690197467804,
0.07479194551706314,
-0.1574699431657791,
0.06706571578979492,
0.2220645546913147,
-0.013696727342903614,
0.08251256495714188,
0.10898420214653015,
0.16926085948944092,
-0.02320510521531105,
0.12288324534893036,
0.3473632037639618,
-0.19599758088588715,
-0.16026555001735687,
-0.016510602086782455,
0.20216844975948334,
0.10189548134803772,
0.05041687563061714,
-0.10741107165813446,
0.12117322534322739,
0.15383625030517578,
-0.06037813052535057,
0.04589524120092392,
-0.07985848933458328,
-0.20195990800857544,
0.03814506158232689,
-0.0998116135597229,
-0.1626095175743103,
-0.14079776406288147,
-0.03176911175251007,
-0.179490864276886,
0.02092898078262806,
0.08088141679763794,
-0.09638649225234985,
0.2005249708890915,
0.3225621283054352,
-0.14582598209381104,
-0.183776393532753,
0.001448497991077602,
-0.00741076935082674,
0.37309038639068604,
0.18095433712005615,
-0.03551872447133064,
-0.06263259053230286,
-0.08954961597919464,
-0.09473427385091782,
-0.0023754085414111614,
0.090785913169384,
-0.19592073559761047,
0.2228350043296814,
-0.11556186527013779,
0.07207909226417542,
-0.2964494824409485,
0.19635646045207977,
-0.019722072407603264,
-0.03163354471325874,
-0.15197286009788513,
-0.03925807774066925,
0.23165221512317657,
0.046613965183496475,
0.08575649559497833,
-0.02858233079314232,
0.005377236753702164,
0.4341011345386505,
0.12333095818758011,
-0.15629754960536957,
0.009316962212324142,
-0.21813808381557465,
0.12431573122739792,
0.036906395107507706,
0.03338475152850151,
0.019683528691530228,
-0.01936504617333412,
0.04474189132452011,
-0.09869503974914551,
-0.06752010434865952,
0.008426702581346035,
-0.12171535938978195,
0.033739324659109116,
0.16639508306980133,
0.21746963262557983,
-0.2547675669193268,
-0.19639165699481964,
-0.11536605656147003,
0.2072731852531433,
-0.3521775007247925,
0.248674675822258,
0.16194921731948853,
0.2402934730052948,
-0.061507321894168854,
0.13703331351280212,
-0.04036189243197441,
-0.06757260859012604,
0.06279201060533524,
-0.07478562742471695,
-0.29064247012138367,
0.08488786220550537,
0.019701460376381874,
-0.2942761480808258,
-0.198585644364357,
-0.2864852547645569,
-0.16464287042617798,
-0.19738884270191193,
0.06674307584762573,
0.10575148463249207,
-0.15020275115966797,
-0.12123297154903412,
0.09050589054822922,
0.07784495502710342,
0.029239093884825706,
-0.08882839977741241,
0.1938437670469284,
-0.12797068059444427,
-0.08753208070993423,
-0.03504890576004982,
-0.01911264844238758,
0.06599094718694687,
-0.021477466449141502,
0.16094334423542023,
0.002234413055703044,
-0.02056892402470112,
0.1302202045917511,
-0.008192796260118484,
0.059291716665029526,
-0.025908291339874268,
0.03512195870280266,
0.15172182023525238,
-0.11673568934202194,
-0.3055804967880249,
0.08764487504959106,
-0.09523264318704605,
-0.12232017517089844,
-0.12461701035499573,
0.01932305283844471,
-0.1333336979150772,
0.1468660980463028,
-0.20910799503326416,
-0.0074293226934969425,
0.02208816446363926,
-0.0809377059340477,
-0.08442764729261398,
-0.022026438266038895,
-0.10247380286455154,
-0.21796861290931702,
-0.27787941694259644,
0.01428302563726902,
-0.22993241250514984,
-0.20159058272838593,
0.01824386976659298,
-0.026199789717793465,
-0.1978544443845749,
-0.16175299882888794,
0.18914927542209625,
0.19058996438980103,
0.1360587626695633,
0.21552477777004242,
0.024574151262640953,
-0.07178393751382828,
0.04006917402148247,
-0.11361955851316452,
0.05933567136526108,
-0.1685548573732376,
-0.05536261200904846,
0.05063113570213318,
0.16401049494743347,
0.07872332632541656,
0.13324323296546936,
-0.21308410167694092,
-0.24242381751537323,
-0.12492388486862183,
-0.09445277601480484,
0.1484028697013855,
-0.10677021741867065,
-0.08790285885334015,
0.06564464420080185,
0.05840156227350235,
0.15340006351470947,
-0.22343331575393677,
0.11053422093391418,
0.00497789029031992,
0.154562845826149,
-0.14395374059677124,
0.18681387603282928,
0.0011963212164118886,
0.11458820849657059,
-0.09983962029218674,
0.06214574724435806,
-0.13894063234329224,
-0.08758099377155304,
-0.1967916339635849,
0.23009458184242249,
0.1969737559556961,
0.10558173060417175,
-0.2647487223148346,
-0.06748580187559128,
0.05873248353600502,
0.17655083537101746,
-0.024109555408358574,
0.06783013045787811,
0.15255580842494965,
-0.21587245166301727,
0.01760585978627205,
-0.04702598601579666,
-0.03991635516285896,
-0.1004575788974762,
0.05016135424375534,
0.08944407105445862,
0.3364150822162628,
0.013583965599536896,
-0.11816562712192535,
-0.02198759652674198,
0.09924577921628952,
0.07990098744630814,
0.18501175940036774,
-0.06491055339574814,
0.1660083681344986,
-0.024649115279316902,
-0.06998084485530853,
-0.12084827572107315,
-0.17192073166370392,
0.17789354920387268,
0.02034190483391285,
-0.03044719435274601,
0.2162247598171234,
-0.093699611723423,
-0.04690184071660042,
0.01749359257519245,
-0.06450513750314713,
0.07632537186145782,
-0.06429330259561539,
-0.09077110886573792,
-0.10887539386749268,
0.07536699622869492,
0.12558428943157196,
0.07699369639158249,
-0.1414332538843155,
0.026764482259750366,
-0.027439875528216362,
-0.011434292420744896,
-0.22558173537254333,
0.08957865834236145,
-0.016334114596247673,
-0.1387890875339508,
-0.046994611620903015,
-0.005070515442639589,
-0.10298871248960495,
-0.1609300822019577,
-0.023034967482089996,
-0.033006422221660614,
0.1849193572998047,
-0.04220016673207283,
-0.3196062743663788,
-0.011706072837114334,
0.026857085525989532,
0.17158247530460358,
0.26441097259521484,
0.11028838902711868,
0.13035525381565094,
0.18461669981479645,
0.048184651881456375,
-0.138938769698143,
-0.16111107170581818,
0.13176271319389343,
0.26089543104171753,
-0.10379251092672348,
-0.1740839183330536,
0.04418513923883438,
0.12369425594806671,
-0.032218918204307556,
0.04111899808049202,
-0.04230354353785515,
-0.056661978363990784,
0.07923690229654312,
0.007039126008749008,
0.03257202357053757,
0.0765061154961586,
0.1747530698776245,
-0.04146042838692665,
-0.094804547727108,
0.005135443527251482,
-0.021948855370283127,
-0.1199987530708313,
-0.053924255073070526,
0.3842296302318573,
-0.0025955629535019398,
0.1156037300825119,
-0.2211926430463791,
-0.008714376017451286,
-0.03753359988331795,
0.04776632785797119,
0.1263665109872818,
0.09343169629573822,
0.03507591784000397,
-0.08447500318288803,
-0.05444538593292236,
-0.011480310000479221,
-0.22521580755710602,
0.18143416941165924,
0.18669281899929047,
0.11955799162387848,
-0.2321922928094864,
-0.16837099194526672,
-0.11553584039211273,
0.11756440997123718,
-0.09849967807531357,
0.08376408368349075,
-0.08083504438400269,
0.13427935540676117,
0.09002507477998734,
0.1231507658958435,
0.0019833191763609648,
0.25874802470207214,
0.026655133813619614,
0.022230736911296844,
-0.0013979837531223893,
0.06164272502064705,
0.011097526177763939,
0.03147882968187332,
-0.08503972738981247,
-0.12820522487163544,
-0.029166975989937782,
0.20603126287460327,
0.15362882614135742,
0.07363400608301163,
0.04353488236665726,
0.10548428446054459,
0.07187379151582718,
-0.2590467035770416,
-0.09080158174037933,
-0.030434491112828255,
-0.07345958054065704,
-0.014994611963629723,
-0.08895308524370193,
0.042242780327796936,
0.0377078615128994,
-0.05487660691142082,
-0.043395765125751495,
0.021759619936347008
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. Hepatomegaly and splenomegaly are common and variable in severity; in one instance massive splenomegaly (spleen measuring 35 cm) has been reported .Liver enzymes may be mildly elevated .Hematologic manifestations. Anemia can be either mild microcytic hypochromic anemia or normocytic normochromic anemia .Hemolysis has been described , with reticulocytosis varying from 5.9% to 8.6% .Thrombocytopenia is fairly common .Immunologic manifestations. Recurrent episodes of otitis media, sinusitis, pneumonia, and gastroenteritis are common .Elevated levels of IgG, IgA and IgM, and hypocomplementemia have been reported , as has decreased neutrophil chemotaxis . Serum levels of C1q have been normal .Increased serum IgE levels have been reported :Martins et al reported a patient with an IgE level of 20,000 IU/mL, which was as high as 77,600 IU/mL on follow up, with a Grimbacher score of 34 .Fukumura et al reported an individual with a level of | [
-0.023793121799826622,
-0.01609230414032936,
0.006890549324452877,
-0.0822390466928482,
0.12767690420150757,
0.08078649640083313,
0.0689263716340065,
-0.006634382531046867,
-0.2181001752614975,
-0.2355993241071701,
0.2090976983308792,
0.049370087683200836,
0.12549635767936707,
0.10183481127023697,
0.03448052331805229,
-0.07558722048997879,
0.05105563998222351,
0.05433866009116173,
-0.05386810377240181,
0.278574675321579,
-0.0375356525182724,
0.053085364401340485,
0.35497137904167175,
0.1822059452533722,
0.4204161763191223,
-0.21652336418628693,
0.031947001814842224,
-0.15735794603824615,
0.09893124550580978,
0.19685521721839905,
0.13345998525619507,
-0.17607282102108002,
-0.2870817184448242,
0.03696490451693535,
0.1532430648803711,
-0.05945982038974762,
-0.12288448959589005,
-0.31414610147476196,
0.2872368395328522,
-0.1853335052728653,
-0.23193393647670746,
-0.046196792274713516,
0.21175746619701385,
0.09474258869886398,
-0.003150582080706954,
-0.24498583376407623,
-0.006189001724123955,
0.049539677798748016,
-0.21773044764995575,
0.051634807139635086,
0.23395179212093353,
-0.14581750333309174,
-0.14030949771404266,
0.014363489113748074,
0.19778312742710114,
0.026041878387331963,
0.13629239797592163,
0.26312124729156494,
0.0715668797492981,
0.19296109676361084,
-0.17857539653778076,
-0.2225898951292038,
-0.00024939377908594906,
-0.31212320923805237,
0.2561371326446533,
-0.14568893611431122,
0.06960520893335342,
-0.08950009196996689,
-0.040562063455581665,
-0.1943458467721939,
0.4232587218284607,
0.1897074282169342,
0.09774994850158691,
0.006166333332657814,
-0.14344006776809692,
0.11426494270563126,
0.04575563967227936,
-0.11537553369998932,
0.02712245099246502,
-0.23688450455665588,
-0.21021121740341187,
0.2668684422969818,
-0.22289450466632843,
0.19281989336013794,
-0.00996274035423994,
0.3471533954143524,
0.1522754728794098,
-0.06805144995450974,
0.22342149913311005,
0.0195817518979311,
-0.13848839700222015,
-0.23094958066940308,
0.012269689701497555,
-0.049529753625392914,
-0.12226135283708572,
-0.14154832065105438,
0.047181036323308945,
-0.08889398723840714,
0.08897827565670013,
0.12804551422595978,
-0.12394512444734573,
-0.029307834804058075,
-0.03847581148147583,
0.08833466470241547,
0.13517789542675018,
-0.2659801244735718,
-0.15686361491680145,
-0.02608320116996765,
-0.2879525423049927,
0.19598697125911713,
0.20287439227104187,
0.07745401561260223,
-0.09137213230133057,
0.08280999213457108,
-0.03837257996201515,
0.10514815151691437,
0.0002892120974138379,
-0.14698942005634308,
-0.07377991825342178,
-0.02503354288637638,
-0.036994077265262604,
0.11368606984615326,
-0.09830818325281143,
0.055192068219184875,
0.18726623058319092,
0.07330896705389023,
0.005264160223305225,
-0.12182198464870453,
0.3653440475463867,
0.07052042335271835,
-0.10345816612243652,
-0.021622315049171448,
-0.09710253030061722,
-0.21052275598049164,
-0.19930045306682587,
0.052884045988321304,
-0.15182897448539734,
-0.169027641415596,
0.08235839009284973,
-0.21144168078899384,
0.042090751230716705,
-0.034936074167490005,
0.26036572456359863,
0.16790059208869934,
0.11394970118999481,
0.06458447128534317,
0.37146663665771484,
0.041495177894830704,
-0.08692391961812973,
0.10896093398332596,
0.22849972546100616,
-0.3394456207752228,
0.5302892327308655,
-0.10757935792207718,
-0.37193620204925537,
0.1066572368144989,
-0.1634398102760315,
-0.07140409201383591,
-0.2809593379497528,
-0.06294716894626617,
0.11982102692127228,
-0.06665008515119553,
0.3328053951263428,
-0.29332324862480164,
0.15871986746788025,
0.05682762339711189,
0.2271890640258789,
-0.24184079468250275,
0.269121378660202,
-0.006243751384317875,
0.09788217395544052,
-0.026664284989237785,
-0.1048424169421196,
0.018364273011684418,
0.13499686121940613,
-0.19950109720230103,
-0.2152062952518463,
0.08096975833177567,
-0.04541376233100891,
-0.15213511884212494,
-0.07925428450107574,
-0.06452879309654236,
-0.23283009231090546,
-0.2531399428844452,
0.05520571768283844,
-0.3248957693576813,
0.07730115950107574,
0.14084254205226898,
0.15892313420772552,
0.18380501866340637,
0.23916852474212646,
-0.03003501519560814,
-0.2845423221588135,
-0.09303248673677444,
-0.10774105787277222,
-0.1705443561077118,
0.03127145394682884,
-0.029473111033439636,
-0.0753127709031105,
-0.06283638626337051,
0.31202664971351624,
-0.29534485936164856,
0.07353249937295914,
-0.03376669064164162,
-0.1078394204378128,
0.24172861874103546,
-0.03729501739144325,
0.17507050931453705,
-0.15127667784690857,
0.32961735129356384,
0.14586412906646729,
0.027411360293626785,
0.004190107807517052,
0.3028358817100525,
-0.16799114644527435,
-0.1615147441625595,
-0.13616904616355896,
-0.12385420501232147,
0.08393993973731995,
-0.06941789388656616,
-0.10629290342330933,
-0.06346342712640762,
0.06715254485607147,
-0.36630088090896606,
-0.10725685954093933,
0.1232743114233017,
-0.029871759936213493,
0.10310370475053787,
-0.08186587691307068,
0.1269962042570114,
-0.21889302134513855,
0.07103902846574783,
0.16520124673843384,
0.07013511657714844,
-0.1580367386341095,
-0.2559892237186432,
0.16158421337604523,
0.2956935465335846,
0.00843941792845726,
0.07883811742067337,
-0.3334931433200836,
-0.04540245980024338,
-0.01355088409036398,
-0.01029710192233324,
-0.21815599501132965,
0.11927959322929382,
-0.12474475800991058,
-0.00008220739255193621,
0.023467212915420532,
-0.02243807166814804,
-0.09926185756921768,
0.12529195845127106,
-0.021192701533436775,
-0.05547500401735306,
-0.3683181703090668,
0.06644138693809509,
0.2408323436975479,
-0.16365228593349457,
0.02747752144932747,
0.0857362225651741,
0.06207628548145294,
0.09738896787166595,
-0.012110219337046146,
0.0354892797768116,
0.02973567135632038,
0.03895486518740654,
-0.1583346575498581,
0.052642542868852615,
-0.07515835016965866,
-0.22876843810081482,
0.004244929179549217,
0.18384352326393127,
0.019681992009282112,
0.09611878544092178,
-0.006649186834692955,
-0.12013382464647293,
-0.14768752455711365,
-0.05702613294124603,
0.3245916962623596,
-0.006145821418613195,
-0.07399143278598785,
-0.14145056903362274,
-0.20262214541435242,
-0.03417937085032463,
0.19642555713653564,
0.07949307560920715,
0.03144950792193413,
0.1175043061375618,
0.028895212337374687,
-0.04426391422748566,
-0.08121240884065628,
0.314972847700119,
-0.1329619586467743,
-0.008362789638340473,
0.00205346685834229,
-0.00781602319329977,
-0.13094229996204376,
-0.090286985039711,
0.10616682469844818,
0.22103825211524963,
0.27281510829925537,
-0.005743871442973614,
-0.07484068721532822,
-0.07721254229545593,
-0.1806243509054184,
0.05145382881164551,
-0.02148306556046009,
0.3098386526107788,
-0.15923729538917542,
0.2513500154018402,
-0.3082699477672577,
-0.1828121840953827,
0.09294634312391281,
-0.08744455128908157,
0.02226654812693596,
-0.151434525847435,
-0.22521395981311798,
0.10345073789358139,
0.16227391362190247,
0.041245125234127045,
0.18684802949428558,
-0.06116831675171852,
0.10075710713863373,
0.24144193530082703,
-0.055637016892433167,
0.07215115427970886,
-0.116480752825737,
0.10002891719341278,
-0.06958995014429092,
0.16404704749584198,
-0.003313896944746375,
-0.06996466964483261,
-0.015754254534840584,
-0.11273995041847229,
0.09028930962085724,
0.10130253434181213,
0.26874953508377075,
0.05572427064180374,
-0.0329921580851078,
-0.00897066481411457,
-0.09552367776632309,
0.0035312811378389597,
0.11150554567575455,
-0.27363187074661255,
-0.09063638746738434,
-0.12481807917356491,
0.09602538496255875,
-0.019033724442124367,
0.1587311327457428,
-0.18915145099163055,
-0.2571067214012146,
0.18947571516036987,
-0.03764810785651207,
-0.11108333617448807,
0.09249100834131241,
0.016385318711400032,
-0.0051595186814665794,
0.13149982690811157,
0.3165616989135742,
-0.3012707829475403,
-0.2189333140850067,
0.10562330484390259,
0.22028426826000214,
-0.051585812121629715,
0.042006198316812515,
0.1427258551120758,
0.0438636839389801,
0.1705351322889328,
0.0023406383115798235,
0.010544814169406891,
-0.03170720115303993,
0.12365182489156723,
0.3117677569389343,
-0.16371095180511475,
0.10341420769691467,
0.010724743828177452,
-0.4205867052078247,
0.15847359597682953,
0.046465612947940826,
0.13724708557128906,
-0.31329628825187683,
0.3361291289329529,
0.10448062419891357,
0.14033254981040955,
0.284052312374115,
0.23351681232452393,
0.030877841636538506,
0.14536958932876587,
-0.05641065537929535,
-0.18805593252182007,
0.2982059717178345,
0.24001245200634003,
-0.06798240542411804,
0.15958872437477112,
0.04903551936149597,
0.08210937678813934,
-0.09670015424489975,
0.032920390367507935,
-0.11072816699743271,
0.15297831594944,
-0.17446820437908173,
0.08412240445613861,
0.1312962919473648,
0.16471527516841888,
0.3024691939353943,
0.15746772289276123,
-0.0701112225651741,
0.1687185913324356,
0.025898559018969536,
-0.1289156973361969,
0.04286012798547745,
-0.20882050693035126,
-0.16878728568553925,
-0.054997120052576065,
0.027727501466870308,
-0.03521779179573059,
0.025710467249155045,
0.1163577064871788,
0.2784838378429413,
0.012008543126285076,
-0.13050222396850586,
-0.38476625084877014,
0.3452727198600769,
0.02146150916814804,
0.11493995785713196,
0.04338246211409569,
0.30054983496665955,
-0.09897899627685547,
0.07601724565029144,
-0.08181817084550858,
-0.08329204469919205,
0.12427806109189987,
0.06289130449295044,
0.06885699927806854,
0.1956103891134262,
-0.03338310122489929,
0.12783017754554749,
0.0742981880903244,
0.4224093556404114,
-0.10316115617752075,
0.2761411964893341,
0.13553538918495178,
-0.2753576338291168,
-0.2517431080341339,
0.0248660147190094,
0.1753992736339569,
0.08511599153280258,
0.00593344634398818,
-0.05294112488627434,
0.014670570380985737,
0.2434970587491989,
-0.12168385088443756,
0.05963096395134926,
-0.012875967659056187,
-0.2584936320781708,
-0.014802461490035057,
-0.05327872931957245,
-0.06255433708429337,
-0.0687466561794281,
-0.10276451706886292,
-0.21296483278274536,
-0.04274289309978485,
-0.09710168093442917,
-0.14561069011688232,
0.15607516467571259,
0.2833368182182312,
-0.12114398181438446,
-0.2758212983608246,
0.06602936238050461,
0.01597689278423786,
0.2967108488082886,
0.13916604220867157,
-0.04984581843018532,
-0.1677003800868988,
-0.09613385051488876,
-0.19406314194202423,
0.0769304484128952,
0.14744865894317627,
-0.12487562745809555,
0.22850261628627777,
-0.18440455198287964,
0.018076468259096146,
-0.34650492668151855,
0.2302584946155548,
-0.07796834409236908,
-0.10256237536668777,
-0.08893237262964249,
-0.06189211830496788,
0.19504103064537048,
-0.05482064560055733,
0.06561672687530518,
-0.02846890687942505,
-0.023254314437508583,
0.3362683057785034,
0.05028754472732544,
-0.04235317185521126,
-0.053847987204790115,
-0.011423474177718163,
0.26466915011405945,
0.08097831904888153,
0.10304523259401321,
0.18848738074302673,
0.12300321459770203,
-0.008656769059598446,
0.019234975799918175,
-0.07894813269376755,
-0.05032346025109291,
-0.0604267418384552,
0.05420522019267082,
0.17684297263622284,
0.17009304463863373,
-0.10021819919347763,
-0.14577679336071014,
-0.07140819728374481,
0.10462647676467896,
-0.26020100712776184,
0.1644565910100937,
0.05458129942417145,
0.28490838408470154,
0.018023813143372536,
0.08606457710266113,
-0.14164330065250397,
-0.0895375981926918,
0.01465027965605259,
0.011652199551463127,
-0.31385716795921326,
0.056810300797224045,
-0.03606202453374863,
-0.2461608499288559,
-0.2038196325302124,
-0.0772596150636673,
-0.10745913535356522,
-0.21424145996570587,
0.20288415253162384,
0.14373067021369934,
-0.1546584516763687,
-0.12374168634414673,
0.18879207968711853,
-0.015029046684503555,
-0.0586317740380764,
-0.12136555463075638,
0.14509785175323486,
-0.08980659395456314,
-0.09477638453245163,
0.190353661775589,
0.012966037727892399,
-0.23345553874969482,
0.018812641501426697,
0.20784862339496613,
-0.14810439944267273,
-0.0018681067740544677,
-0.030178295448422432,
-0.08217590302228928,
0.05040360987186432,
-0.14064931869506836,
0.008168305270373821,
0.18308818340301514,
-0.11676182597875595,
-0.10194041579961777,
0.08970325440168381,
-0.03129072114825249,
-0.030389120802283287,
-0.133834570646286,
-0.032815005630254745,
-0.15981394052505493,
0.14785201847553253,
-0.0882953405380249,
0.010556606575846672,
-0.02926677279174328,
-0.0796980932354927,
0.059645820409059525,
-0.08868756145238876,
-0.02437116578221321,
-0.08060035854578018,
-0.29218435287475586,
0.030945416539907455,
-0.2677778899669647,
-0.2454701066017151,
-0.11079058796167374,
-0.11569096148014069,
-0.2042083889245987,
-0.068339042365551,
0.23976480960845947,
0.14279420673847198,
0.15336677432060242,
0.021802393719553947,
0.10256222635507584,
-0.21189947426319122,
-0.11501573026180267,
-0.05134986713528633,
0.20889633893966675,
-0.1320069283246994,
-0.053578343242406845,
-0.10527515411376953,
0.2678423821926117,
0.20983180403709412,
0.11572498828172684,
-0.06550378352403641,
-0.10055691003799438,
-0.15608574450016022,
-0.02990255504846573,
0.010962555184960365,
-0.09545797854661942,
-0.14563409984111786,
-0.033535655587911606,
-0.09949427098035812,
0.12473318725824356,
-0.23895186185836792,
0.20305359363555908,
0.04535301402211189,
0.12149717658758163,
-0.14202886819839478,
0.09699560701847076,
0.008529430255293846,
0.08868405967950821,
-0.03516975790262222,
0.15259134769439697,
-0.2525485157966614,
-0.2254028469324112,
-0.2673296332359314,
0.29637372493743896,
-0.0124417869374156,
0.20236587524414062,
-0.15856337547302246,
-0.1230575293302536,
0.1373140513896942,
0.06280705332756042,
-0.06866542249917984,
0.06571007519960403,
0.07407182455062866,
-0.09733676165342331,
-0.023251548409461975,
-0.025092802941799164,
0.06859763711690903,
-0.0989522859454155,
0.10570409148931503,
0.1443025916814804,
0.4336559772491455,
0.19474276900291443,
0.028997477144002914,
0.09965869039297104,
-0.2051568329334259,
0.24161343276500702,
0.08364444971084595,
0.08796411007642746,
0.08564861118793488,
-0.23646846413612366,
-0.21758563816547394,
-0.025826260447502136,
-0.07409950345754623,
0.2547767758369446,
0.0011806372785940766,
-0.007852029986679554,
0.08118003606796265,
-0.0024213807191699743,
-0.05626017972826958,
-0.005220690276473761,
-0.12074576318264008,
-0.07388965040445328,
-0.2118309587240219,
0.06133977323770523,
-0.2236979454755783,
-0.15972256660461426,
0.0267737228423357,
0.04996037110686302,
-0.3000563979148865,
-0.02975473552942276,
0.006444462575018406,
0.02530078962445259,
-0.22340911626815796,
0.15551702678203583,
0.1289490908384323,
-0.11634835600852966,
-0.18232472240924835,
-0.07782229781150818,
-0.08691778779029846,
-0.048743586987257004,
0.004482990596443415,
0.03325002267956734,
0.2838602066040039,
0.0057829017750918865,
-0.20744635164737701,
0.1388164907693863,
0.09310005605220795,
-0.06361158937215805,
0.34774017333984375,
0.025597328320145607,
-0.013825032860040665,
-0.00547007517889142,
0.025327570736408234,
-0.03863987699151039,
-0.14927658438682556,
0.08197111636400223,
0.19743697345256805,
-0.16700518131256104,
-0.12070851027965546,
0.11729306727647781,
0.15123334527015686,
0.0870843306183815,
-0.018942678347229958,
0.09774970263242722,
0.03216543793678284,
-0.07775536179542542,
-0.0009440456051379442,
0.08898612856864929,
0.23892848193645477,
0.010104925371706486,
-0.021987279877066612,
-0.09768730401992798,
-0.08693285286426544,
0.03752819076180458,
-0.018695080652832985,
-0.054970767349004745,
0.23095035552978516,
0.14782261848449707,
0.12926723062992096,
-0.1878575086593628,
0.055796343833208084,
-0.024521712213754654,
0.11193665862083435,
0.11538691818714142,
-0.014599813148379326,
-0.076178178191185,
-0.22470448911190033,
-0.21883507072925568,
0.0038002394139766693,
-0.08157093822956085,
0.18774215877056122,
0.04253087192773819,
-0.03452008590102196,
-0.163736030459404,
-0.24618127942085266,
0.03627406805753708,
0.12291611731052399,
-0.10955018550157547,
0.02793247066438198,
0.11104565858840942,
0.04638808220624924,
0.0750061571598053,
0.1470930576324463,
-0.08684595674276352,
0.1758348047733307,
0.03217465057969093,
0.09270577132701874,
0.01982100121676922,
0.1472707986831665,
-0.1779038906097412,
-0.008861075155436993,
-0.012442321516573429,
-0.05217299982905388,
0.006395968608558178,
0.3259362280368805,
0.21950091421604156,
-0.02341919019818306,
0.11723759025335312,
0.24103134870529175,
-0.0706428736448288,
-0.331098347902298,
-0.2637558579444885,
-0.040815018117427826,
-0.061851706355810165,
0.02144588716328144,
0.03127816691994667,
-0.025957580655813217,
0.05346362292766571,
-0.21197010576725006,
-0.017903968691825867,
-0.008367705158889294
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. are common .Elevated levels of IgG, IgA and IgM, and hypocomplementemia have been reported , as has decreased neutrophil chemotaxis . Serum levels of C1q have been normal .Increased serum IgE levels have been reported :Martins et al reported a patient with an IgE level of 20,000 IU/mL, which was as high as 77,600 IU/mL on follow up, with a Grimbacher score of 34 .Fukumura et al reported an individual with a level of 23,000 IU/mL.Hershkovitz et al reported a patient with levels of 1,000-2,000 IU/mL with a Grimbacher score of 41, suggestive of autosomal dominant hyper IgE syndrome.Pulmonary manifestations. Asthma-like chronic reactive airway disease was described in three of four Amish individuals with prolidase deficiency .Bronchiectasis, chronic lipoid pneumonia, and a cystic fibrosis phenotype including elevated sweat chloride and transepithelial potential difference has been | [
-0.18123981356620789,
0.043290361762046814,
0.062111690640449524,
-0.05935079604387283,
0.1790602207183838,
0.16219066083431244,
0.07894980907440186,
-0.07621749490499496,
-0.2022411972284317,
-0.24397115409374237,
0.21448223292827606,
-0.00923561304807663,
0.15018416941165924,
-0.0007488139090128243,
-0.010663111694157124,
0.09753860533237457,
0.03153109550476074,
-0.01324903778731823,
0.011163664981722832,
0.08737122267484665,
-0.023769062012434006,
0.06103761866688728,
0.258076936006546,
0.190353125333786,
0.3355133831501007,
-0.08339846879243851,
-0.11763139814138412,
-0.08343560248613358,
0.15209446847438812,
0.054546453058719635,
0.06588922441005707,
0.05141180381178856,
-0.21373027563095093,
-0.05990354344248772,
0.06570195406675339,
-0.02053484320640564,
-0.163664773106575,
-0.16326561570167542,
0.0624675527215004,
-0.14476852118968964,
-0.22233690321445465,
-0.09855206310749054,
0.051445357501506805,
-0.01674976386129856,
0.04167282581329346,
-0.14451563358306885,
0.04080600664019585,
-0.08327507227659225,
-0.3048303425312042,
-0.020641984418034554,
0.12559257447719574,
-0.06292340159416199,
-0.1425170600414276,
-0.010413028299808502,
0.1673227697610855,
0.006784780882298946,
0.11529358476400375,
0.1419755518436432,
-0.14903077483177185,
0.08314629644155502,
-0.13849428296089172,
-0.21137690544128418,
0.05346066877245903,
-0.3411923944950104,
0.2660607099533081,
-0.14264822006225586,
0.1131674125790596,
0.020134789869189262,
-0.00570344366133213,
0.0699240192770958,
0.21148090064525604,
0.19305220246315002,
0.0909159705042839,
-0.022655397653579712,
-0.0715314969420433,
0.0814380943775177,
0.008937898091971874,
0.030718043446540833,
-0.009514594450592995,
-0.13454343378543854,
-0.1833972930908203,
0.3745598793029785,
-0.11313091963529587,
0.25065478682518005,
-0.0629630982875824,
0.2342621386051178,
0.22795362770557404,
0.11654843389987946,
0.13683892786502838,
-0.02391732670366764,
-0.031927719712257385,
-0.13959284126758575,
0.1391889452934265,
-0.10321052372455597,
-0.02692497707903385,
-0.0836763083934784,
-0.029018836095929146,
-0.10047387331724167,
0.012898039072751999,
0.1872241199016571,
-0.07685619592666626,
-0.008341822773218155,
-0.10155708342790604,
0.09934812784194946,
0.08010715991258621,
-0.08978014439344406,
-0.09019627422094345,
-0.07020477205514908,
-0.19540947675704956,
-0.08565638214349747,
0.1803050935268402,
0.12115190923213959,
0.011960108764469624,
0.21091227233409882,
-0.01521916314959526,
-0.007131270598620176,
0.05083215609192848,
-0.11992849409580231,
-0.17756450176239014,
0.06344202905893326,
-0.07379632443189621,
0.1208992600440979,
0.0787062868475914,
-0.07504716515541077,
0.1102372333407402,
0.27873122692108154,
-0.02288975566625595,
-0.0441330187022686,
0.42811650037765503,
-0.04810531437397003,
0.08451651781797409,
-0.04373052343726158,
-0.22757896780967712,
-0.05787757411599159,
0.012485661543905735,
-0.14769209921360016,
-0.15624256432056427,
-0.12415207922458649,
-0.05370059981942177,
-0.1450190395116806,
0.0268015805631876,
-0.05899232253432274,
0.19123999774456024,
0.226377472281456,
-0.08057573437690735,
0.04716179147362709,
0.31265968084335327,
0.018008537590503693,
-0.03224094957113266,
0.24627535045146942,
0.11233298480510712,
-0.22136825323104858,
0.32838335633277893,
-0.10190438479185104,
-0.08430866152048111,
0.056560829281806946,
-0.13605724275112152,
0.08126682043075562,
-0.04301242157816887,
0.09190050512552261,
0.09949525445699692,
-0.04185599461197853,
0.06993132084608078,
-0.33128392696380615,
0.1537562906742096,
-0.0896710455417633,
0.1336209923028946,
-0.08841241896152496,
0.1990392804145813,
-0.07688716799020767,
0.0037903725169599056,
-0.04276340827345848,
-0.15882739424705505,
0.06109995022416115,
0.16551469266414642,
-0.19201698899269104,
-0.04036858305335045,
0.006459929049015045,
0.020189091563224792,
0.07256202399730682,
-0.046182021498680115,
-0.02569175325334072,
-0.19579601287841797,
-0.01687491685152054,
0.03297966718673706,
-0.2616897225379944,
0.13069137930870056,
0.17032277584075928,
0.034083593636751175,
0.17583252489566803,
0.32988449931144714,
0.01576044037938118,
-0.22178392112255096,
-0.005372331477701664,
0.11055975407361984,
-0.2646271884441376,
0.0832577645778656,
-0.10675567388534546,
-0.06911879777908325,
-0.04274545982480049,
0.12872043251991272,
-0.26028719544410706,
0.08518475294113159,
0.042219992727041245,
-0.08753681927919388,
0.2076168954372406,
-0.037380293011665344,
-0.08570583164691925,
-0.049459658563137054,
0.36405321955680847,
-0.05230022594332695,
0.16466979682445526,
-0.09422250092029572,
0.17324143648147583,
-0.13440032303333282,
-0.00005584882092080079,
-0.10053303837776184,
-0.18145419657230377,
0.09178650379180908,
-0.17851054668426514,
-0.09492289274930954,
-0.07776512950658798,
-0.018394649028778076,
-0.2739870846271515,
0.04162219539284706,
0.14547699689865112,
-0.09275636076927185,
-0.1001642718911171,
-0.003812325419858098,
0.12470053136348724,
-0.03380412980914116,
0.05836858972907066,
0.10411291569471359,
0.06789248436689377,
-0.16105535626411438,
-0.23471274971961975,
0.14974428713321686,
0.21016265451908112,
0.03951231762766838,
-0.04952388256788254,
-0.24309633672237396,
-0.046971727162599564,
-0.05653931200504303,
-0.011503277346491814,
-0.0788041353225708,
0.04626353830099106,
-0.11226820200681686,
-0.03841860592365265,
-0.05552931874990463,
0.05461079999804497,
-0.05313602834939957,
-0.03272205591201782,
-0.008969750255346298,
0.056537240743637085,
-0.35196053981781006,
-0.057260479778051376,
0.12604458630084991,
-0.18600061535835266,
0.10258764028549194,
0.02740459516644478,
0.04187813028693199,
0.0263762678951025,
0.061169616878032684,
0.12086082994937897,
-0.09385371953248978,
-0.029228201135993004,
-0.10221786797046661,
-0.0019450453110039234,
-0.0662098154425621,
-0.04603927582502365,
-0.036446671932935715,
0.04097156599164009,
0.05587974935770035,
0.01188925001770258,
-0.18810909986495972,
-0.03074093535542488,
-0.060315459966659546,
0.03066001832485199,
0.2799893617630005,
-0.05763489380478859,
-0.017825787886977196,
-0.05375370755791664,
-0.1085069328546524,
0.025949208065867424,
0.28838643431663513,
-0.07133068144321442,
0.019025128334760666,
0.07698417454957962,
-0.1362895369529724,
-0.026213031262159348,
-0.005744681227952242,
0.0874168872833252,
-0.03198913112282753,
0.007944145239889622,
0.09692174196243286,
0.09329458326101303,
-0.1369469314813614,
-0.11794533580541611,
0.25555676221847534,
0.16891826689243317,
0.20908941328525543,
0.015250121243298054,
-0.04704371094703674,
-0.16899226605892181,
-0.1302206963300705,
0.032229889184236526,
0.11599326133728027,
0.1121978610754013,
-0.15432853996753693,
0.06351953744888306,
-0.23607605695724487,
-0.012322465889155865,
0.022555457428097725,
-0.08976108580827713,
0.05356679856777191,
-0.040589701384305954,
-0.1587960571050644,
0.07243785262107849,
0.1935177892446518,
-0.01487820129841566,
0.04566478356719017,
0.03326141834259033,
0.03866439312696457,
0.3236593008041382,
-0.1408195048570633,
0.08790630847215652,
-0.04579553380608559,
-0.08730267733335495,
-0.02202531322836876,
0.10074909776449203,
-0.013285481370985508,
-0.06056268513202667,
0.012778686359524727,
-0.07724962383508682,
-0.06424154341220856,
0.16259759664535522,
0.2738180160522461,
-0.058685753494501114,
-0.10217952728271484,
0.06326908618211746,
-0.05992157757282257,
-0.1014898419380188,
-0.003133839461952448,
-0.11466782540082932,
-0.04284845292568207,
-0.021387379616498947,
0.14467577636241913,
-0.013812270015478134,
0.15469714999198914,
-0.16328075528144836,
-0.20205144584178925,
0.07400359958410263,
-0.04221324995160103,
-0.07208873331546783,
0.014363800175487995,
0.07644522190093994,
-0.03499630093574524,
0.07497275620698929,
0.11376212537288666,
-0.1745138168334961,
-0.12811578810214996,
0.026675840839743614,
0.10686006397008896,
0.01091055292636156,
0.176236093044281,
0.11468835175037384,
0.10105577856302261,
0.2461174577474594,
0.1744762659072876,
-0.0624249093234539,
-0.01582357846200466,
0.015935195609927177,
0.30903154611587524,
-0.019201228395104408,
0.0018248625565320253,
-0.12101113796234131,
-0.1221015527844429,
0.1901577264070511,
-0.1325925886631012,
0.06038914620876312,
-0.1920509785413742,
0.21093951165676117,
0.1041276827454567,
0.2621205151081085,
0.16759614646434784,
0.12912943959236145,
0.05888679623603821,
0.12594059109687805,
-0.07006457448005676,
-0.05985833704471588,
0.1767634004354477,
0.17386342585086823,
0.02986270561814308,
0.057051945477724075,
0.0059416708536446095,
0.041000768542289734,
0.047737427055835724,
0.022533830255270004,
-0.19792522490024567,
0.1253867745399475,
-0.15169349312782288,
0.0745285302400589,
0.1845305860042572,
0.19041264057159424,
0.2582000494003296,
0.18641729652881622,
-0.004963289946317673,
0.1393410861492157,
-0.0010411323746666312,
-0.07763292640447617,
0.03376128152012825,
-0.1749848574399948,
-0.13870194554328918,
-0.13732947409152985,
0.0641818642616272,
-0.011657839640974998,
0.12425130605697632,
0.13334780931472778,
0.16218557953834534,
0.03510395064949989,
0.0025243537966161966,
-0.08889211714267731,
0.24252459406852722,
0.03634107857942581,
0.1638154685497284,
-0.016740374267101288,
0.11763543635606766,
-0.06585389375686646,
0.2517849802970886,
0.0724545568227768,
-0.0218422319740057,
0.15678881108760834,
-0.09241369366645813,
-0.1167033389210701,
0.15860605239868164,
0.006874370854347944,
0.1565246880054474,
0.20694825053215027,
0.2724536955356598,
-0.10806554555892944,
0.2448943555355072,
-0.050407517701387405,
-0.2161843180656433,
-0.09358576685190201,
-0.008680175989866257,
-0.05154109001159668,
0.11109746247529984,
0.019370505586266518,
-0.013606478460133076,
0.10964234918355942,
0.16831739246845245,
-0.11695782095193863,
0.06836844980716705,
-0.06468665599822998,
-0.20185314118862152,
0.1556275188922882,
0.04914718493819237,
-0.21943865716457367,
-0.09275710582733154,
-0.07741115987300873,
-0.015648776665329933,
0.027093984186649323,
-0.0034884021151810884,
-0.14213158190250397,
0.024396445602178574,
0.26392826437950134,
-0.11453874409198761,
-0.15372946858406067,
-0.017006652429699898,
0.11462687700986862,
0.18067234754562378,
0.10142597556114197,
-0.09532652050256729,
-0.07646600157022476,
-0.029633479192852974,
-0.19715222716331482,
0.013330763205885887,
0.12119399011135101,
-0.12881653010845184,
0.06685389578342438,
-0.10123962163925171,
-0.008236232213675976,
-0.2992703318595886,
0.038973141461610794,
0.02621651068329811,
-0.09903571754693985,
0.10646520555019379,
-0.0976644828915596,
0.1597396284341812,
0.11744724214076996,
-0.07437840104103088,
-0.04808967560529709,
0.0706324353814125,
0.33877137303352356,
0.11894243210554123,
-0.10891168564558029,
-0.029742704704403877,
-0.006744242738932371,
0.08838137984275818,
-0.01808026246726513,
-0.03846599534153938,
0.029667237773537636,
0.11216729879379272,
0.12409160286188126,
0.030275899916887283,
-0.10479539632797241,
0.10210901498794556,
-0.060587722808122635,
0.004246234893798828,
0.27347326278686523,
0.22384211421012878,
0.08016111701726913,
-0.08820389956235886,
-0.18347151577472687,
0.07208060473203659,
-0.16596025228500366,
0.08074534684419632,
0.10551857203245163,
0.2975526750087738,
0.15182064473628998,
0.05779785290360451,
-0.3572278916835785,
0.0019939022604376078,
0.06617362797260284,
-0.032891783863306046,
-0.22100301086902618,
0.059172000735998154,
-0.08838675171136856,
-0.17354346811771393,
-0.16214847564697266,
-0.10036145150661469,
-0.2356201410293579,
-0.08172640949487686,
-0.023058976978063583,
0.0687091127038002,
-0.06835095584392548,
-0.020815182477235794,
0.11501485854387283,
-0.1185993105173111,
-0.21863482892513275,
-0.12412899732589722,
0.05829361453652382,
-0.1271136999130249,
-0.12613548338413239,
0.013719681650400162,
0.10362149775028229,
-0.15734486281871796,
0.03227994218468666,
0.11785267293453217,
-0.004880433436483145,
0.004193841479718685,
-0.12265648692846298,
-0.04142584651708603,
0.006188062950968742,
-0.0013832008698955178,
-0.025279168039560318,
0.21781155467033386,
-0.10152047872543335,
-0.05095120519399643,
0.13969841599464417,
-0.12282215058803558,
-0.08256792277097702,
-0.15796060860157013,
-0.017605626955628395,
-0.18854142725467682,
0.08740104734897614,
-0.06629428267478943,
-0.19773226976394653,
-0.1087961494922638,
-0.20524607598781586,
-0.03270867466926575,
-0.07542794197797775,
0.07413099706172943,
-0.1628749817609787,
-0.08515866845846176,
-0.01694733463227749,
-0.25154146552085876,
-0.30556970834732056,
-0.06886991113424301,
0.039190564304590225,
-0.22236661612987518,
-0.08550577610731125,
0.1771761178970337,
0.15288160741329193,
0.1859898418188095,
0.09454602748155594,
0.05437324568629265,
0.027611449360847473,
0.0754585787653923,
-0.04635379835963249,
0.17112997174263,
-0.14380760490894318,
0.07192825525999069,
-0.13532374799251556,
0.19028258323669434,
0.08376474678516388,
0.08932219445705414,
-0.054121702909469604,
-0.12386500835418701,
-0.16182617843151093,
-0.09240751713514328,
-0.008175753988325596,
-0.16658490896224976,
-0.12326028943061829,
-0.001161176129244268,
-0.023550795391201973,
0.12318381667137146,
-0.28210264444351196,
0.06598250567913055,
0.15084308385849,
-0.16278575360774994,
-0.12129402905702591,
0.006863357033580542,
0.037297848612070084,
0.11266825348138809,
-0.13232971727848053,
0.09212367236614227,
-0.16397032141685486,
-0.1318374127149582,
-0.23268580436706543,
0.2110619992017746,
-0.06475452333688736,
0.20419611036777496,
-0.12308324128389359,
-0.06712253391742706,
0.19058556854724884,
0.0834047794342041,
-0.18713586032390594,
0.16780610382556915,
-0.036078013479709625,
-0.05383104830980301,
0.03969302773475647,
-0.018719453364610672,
0.12150052934885025,
-0.040438730269670486,
0.1309068351984024,
-0.014345355331897736,
0.35118627548217773,
0.0715336874127388,
0.07902506738901138,
-0.0548461452126503,
-0.13755665719509125,
-0.03622190281748772,
0.0776706263422966,
-0.19578275084495544,
0.12355028092861176,
-0.22980956733226776,
-0.10357444733381271,
0.0028800773434340954,
-0.003513095900416374,
0.26817941665649414,
0.08084040135145187,
0.05978688970208168,
0.058767855167388916,
-0.0526941753923893,
-0.03481719270348549,
0.07950906455516815,
-0.11287142336368561,
-0.03851425647735596,
-0.1698479801416397,
0.16306684911251068,
-0.04335246980190277,
-0.20771335065364838,
-0.057812631130218506,
-0.08860137313604355,
-0.17693886160850525,
-0.0776481032371521,
-0.03816988319158554,
0.12476429343223572,
-0.1393439620733261,
0.20002368092536926,
0.2471475452184677,
0.06372205913066864,
-0.14492656290531158,
0.05974036827683449,
-0.06190801411867142,
-0.008142870850861073,
-0.03854699432849884,
0.05331370607018471,
0.2639220952987671,
-0.06730348616838455,
-0.20483887195587158,
0.04205593094229698,
0.12730377912521362,
0.16484016180038452,
0.08210568130016327,
0.0013334432151168585,
-0.1701572835445404,
0.027925485745072365,
0.03105226904153824,
-0.10121618211269379,
-0.054816119372844696,
-0.051085084676742554,
0.1465734839439392,
-0.1593465805053711,
-0.1045762449502945,
0.1503916084766388,
0.15323278307914734,
0.09853000938892365,
-0.13591700792312622,
0.16263528168201447,
0.07544419914484024,
0.10733386874198914,
0.06455075740814209,
0.1644241213798523,
0.11873514205217361,
0.033662065863609314,
-0.14571931958198547,
-0.10486796498298645,
0.010997166857123375,
-0.06875891238451004,
0.05472159385681152,
-0.014163821004331112,
0.09628056734800339,
0.0897931158542633,
0.19717954099178314,
-0.19161207973957062,
-0.003952734172344208,
-0.06362856179475784,
0.10578390210866928,
0.05912930890917778,
0.039093971252441406,
-0.06244301795959473,
-0.2176685929298401,
-0.060302428901195526,
0.15695683658123016,
0.06307896971702576,
0.273480623960495,
0.1103014126420021,
-0.07438090443611145,
-0.0063361213542521,
-0.1648934781551361,
-0.201740562915802,
0.012635436840355396,
-0.06172831356525421,
-0.001907851081341505,
0.014493891969323158,
-0.10400238633155823,
0.16766875982284546,
0.08100344985723495,
-0.16147573292255402,
0.10304248332977295,
0.0070733437314629555,
0.03094714879989624,
0.1834389716386795,
0.07639770209789276,
-0.02380824275314808,
-0.054746516048908234,
-0.11800477653741837,
0.08463086932897568,
0.0424627959728241,
0.21039752662181854,
0.2002898007631302,
0.0037924672942608595,
0.11305057257413864,
0.11847749352455139,
-0.016819370910525322,
-0.13867387175559998,
0.06292472034692764,
0.169745072722435,
-0.0624900721013546,
0.039137933403253555,
0.10747047513723373,
-0.007101545576006174,
0.003985799383372068,
0.008648992516100407,
0.03670457750558853,
0.04782756045460701
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. an individual with a level of 23,000 IU/mL.Hershkovitz et al reported a patient with levels of 1,000-2,000 IU/mL with a Grimbacher score of 41, suggestive of autosomal dominant hyper IgE syndrome.Pulmonary manifestations. Asthma-like chronic reactive airway disease was described in three of four Amish individuals with prolidase deficiency .Bronchiectasis, chronic lipoid pneumonia, and a cystic fibrosis phenotype including elevated sweat chloride and transepithelial potential difference has been described .One male developed severe progressive restrictive lung disease at age 45 years .A Druze woman age 24 years had progressive lung disease with chest CT findings of mainly cystic lung lesions and ground glass opacity . She experienced further deterioration in her pulmonary function and secondary pulmonary hypertension, and became oxygen dependent.An Amish boy age six years with pulmonary hypertension required supplemental oxygen .Systemic lupus erythematosus-like findings. An association between systemic lupus erythematosus (SLE) and prolidase deficiency has | [
-0.20956942439079285,
0.007206992246210575,
-0.030038969591259956,
-0.12575902044773102,
0.10788638144731522,
0.061548929661512375,
0.11404397338628769,
-0.12570467591285706,
-0.11526487022638321,
-0.22173327207565308,
0.15229806303977966,
0.1546836942434311,
0.20643040537834167,
0.03287428617477417,
-0.000020396122636157088,
0.13714279234409332,
0.10876953601837158,
-0.09856422990560532,
-0.06787362694740295,
0.02972245402634144,
-0.0039131189696490765,
0.05925547704100609,
0.2658875584602356,
0.12972892820835114,
0.32181987166404724,
-0.054197151213884354,
-0.020794954150915146,
-0.054592955857515335,
0.13202953338623047,
0.11223749071359634,
-0.022843504324555397,
-0.08825935423374176,
-0.06953004002571106,
-0.16556864976882935,
0.14778675138950348,
-0.13503184914588928,
-0.11386818438768387,
-0.0443752184510231,
0.0698869600892067,
-0.039039503782987595,
-0.09002263844013214,
-0.059723492711782455,
0.019797058776021004,
-0.022420914843678474,
0.0188027061522007,
-0.1534258872270584,
0.018969345837831497,
-0.01475679874420166,
-0.21219228208065033,
0.042672764509916306,
0.165873721241951,
-0.12510885298252106,
0.0024716658517718315,
-0.07861685752868652,
0.11426763981580734,
0.005267371889203787,
0.04280238598585129,
0.061124496161937714,
-0.13194400072097778,
0.0555083304643631,
0.005976014770567417,
-0.10874375700950623,
0.0053079016506671906,
-0.37848329544067383,
0.2509608566761017,
-0.06567929685115814,
0.06897581368684769,
-0.005932909902185202,
-0.03690279275178909,
-0.01538657397031784,
0.29671555757522583,
0.06685622781515121,
0.23455233871936798,
0.0450177863240242,
-0.08450020104646683,
0.01465277373790741,
0.072837233543396,
-0.017101861536502838,
-0.001473148469813168,
-0.08973386138677597,
-0.14698296785354614,
0.20779967308044434,
-0.08273895829916,
0.12877213954925537,
-0.09849248081445694,
0.21359755098819733,
0.1986679881811142,
0.11630110442638397,
0.12421529740095139,
-0.06529632955789566,
0.06009601429104805,
-0.1295069307088852,
0.1843019723892212,
-0.19180278480052948,
-0.09615769982337952,
-0.06970075517892838,
0.010502194985747337,
-0.040864959359169006,
-0.0039834026247262955,
0.16691547632217407,
-0.019655808806419373,
0.04192958027124405,
-0.13735444843769073,
0.08888701349496841,
0.015272158198058605,
-0.05977959558367729,
-0.10104286670684814,
-0.09960918128490448,
-0.11897126585245132,
-0.10816370695829391,
0.19395750761032104,
-0.015505812130868435,
-0.0016418095910921693,
0.1216161847114563,
-0.04843921214342117,
0.13733893632888794,
0.10659235715866089,
-0.09384556114673615,
-0.11653381586074829,
-0.062383897602558136,
-0.02735067531466484,
0.13943932950496674,
0.022595925256609917,
-0.029277963563799858,
0.13742470741271973,
0.1940377652645111,
0.055952318012714386,
0.09260885417461395,
0.3160305917263031,
-0.05388690531253815,
0.1143713891506195,
0.02627340331673622,
-0.1728629618883133,
-0.08952349424362183,
-0.03288794308900833,
-0.1389615535736084,
-0.31448376178741455,
-0.20622457563877106,
-0.03251758590340614,
-0.1365060657262802,
-0.010501357726752758,
-0.059800829738378525,
0.14941300451755524,
0.2436012625694275,
0.13089978694915771,
0.000022937221729080193,
0.29899224638938904,
0.05557813122868538,
0.06992267817258835,
0.21188411116600037,
0.10587512701749802,
-0.13016444444656372,
0.3385845422744751,
-0.10211166739463806,
-0.056108441203832626,
0.05559398978948593,
-0.16972358524799347,
0.0752408429980278,
-0.10260108858346939,
0.15965990722179413,
0.11759493499994278,
-0.06745075434446335,
0.1025690957903862,
-0.21868203580379486,
0.10928099602460861,
0.009595438838005066,
-0.023118723183870316,
0.01742047816514969,
0.12537218630313873,
-0.034517768770456314,
-0.16812720894813538,
0.06790938973426819,
-0.15559470653533936,
0.09062480181455612,
0.13236898183822632,
-0.17428725957870483,
-0.023706072941422462,
0.06469131261110306,
0.030390094965696335,
0.10682210326194763,
0.02388094924390316,
-0.07985443621873856,
-0.26353201270103455,
-0.03600338473916054,
0.039111122488975525,
-0.21025396883487701,
0.11361544579267502,
0.17762507498264313,
0.0005597492563538253,
0.13019417226314545,
0.17218948900699615,
0.06990234553813934,
-0.14613410830497742,
-0.08386509120464325,
0.13749900460243225,
-0.27736130356788635,
0.11135615408420563,
-0.10421041399240494,
-0.1032770499587059,
-0.0014110658084973693,
0.1636856496334076,
-0.3028091788291931,
0.05283041298389435,
-0.03278355672955513,
-0.09850548207759857,
0.17093749344348907,
-0.06473919004201889,
-0.028236614540219307,
-0.07767883688211441,
0.30270519852638245,
-0.02412063628435135,
0.10965149104595184,
-0.07132185995578766,
0.15056876838207245,
-0.16705968976020813,
-0.08272640407085419,
-0.1390504688024521,
-0.1552003026008606,
0.015256683342158794,
-0.1966393142938614,
0.027548419311642647,
-0.029774388298392296,
0.08158707618713379,
-0.264603853225708,
0.0092605110257864,
0.12368838489055634,
-0.05194380506873131,
0.02413414604961872,
0.038688186556100845,
0.06485746800899506,
-0.02406083419919014,
-0.07202999293804169,
0.07614303380250931,
0.15079806745052338,
-0.05538990721106529,
-0.16612888872623444,
0.11645548790693283,
0.20702089369297028,
0.07229999452829361,
-0.0708787590265274,
-0.2934544086456299,
-0.03033967688679695,
-0.05719366297125816,
0.03087899647653103,
-0.016082849353551865,
-0.005089448764920235,
-0.12208020687103271,
0.06645827740430832,
-0.011646784842014313,
-0.01953103207051754,
-0.08951624482870102,
-0.026052581146359444,
0.024680104106664658,
0.04243946075439453,
-0.3979906737804413,
-0.06998046487569809,
0.12675230205059052,
-0.09956784546375275,
0.09179908782243729,
0.0450398214161396,
-0.05485186353325844,
-0.027204934507608414,
0.13457588851451874,
0.19640712440013885,
-0.0040626307018101215,
-0.07670794427394867,
-0.12383005023002625,
0.11885279417037964,
-0.10161298513412476,
-0.15659357607364655,
-0.014617460779845715,
-0.007643749006092548,
0.08259731531143188,
0.07611387968063354,
-0.18058077991008759,
-0.10760802775621414,
-0.06975504010915756,
0.05168977007269859,
0.1643078476190567,
-0.03506045043468475,
0.05335775762796402,
-0.02098163217306137,
-0.14959758520126343,
0.05025023967027664,
0.22697144746780396,
0.057718146592378616,
-0.007873992435634136,
0.08291565626859665,
-0.13134202361106873,
0.07605219632387161,
0.12356065213680267,
0.13577064871788025,
-0.14435720443725586,
-0.09788289666175842,
0.07041935622692108,
0.12164322286844254,
-0.057919684797525406,
-0.11806830763816833,
0.16012227535247803,
0.08504903316497803,
0.19807438552379608,
0.12384188175201416,
-0.03150352090597153,
-0.10345163941383362,
-0.11826935410499573,
0.03936966136097908,
0.16311554610729218,
0.13297632336616516,
-0.1404513269662857,
0.13783708214759827,
-0.206470787525177,
-0.09831152856349945,
0.0012634635204449296,
-0.04762916639447212,
-0.024382522329688072,
-0.006480347365140915,
-0.16926632821559906,
0.15761904418468475,
0.13328228890895844,
0.0804641917347908,
0.12517423927783966,
-0.007383707445114851,
0.04745137318968773,
0.2793838381767273,
-0.1199909895658493,
0.12403623014688492,
-0.17439591884613037,
0.014972466044127941,
0.03374345228075981,
0.050220221281051636,
0.060816749930381775,
-0.07749656587839127,
0.026986639946699142,
-0.06471776962280273,
-0.01707245409488678,
0.0928371325135231,
0.25109148025512695,
0.00624208664521575,
-0.019847074523568153,
0.16334359347820282,
0.0413692370057106,
-0.06973782181739807,
-0.0599372498691082,
-0.08511503040790558,
0.011550105176866055,
-0.00232638418674469,
0.010579051449894905,
0.000799022032879293,
0.23916414380073547,
-0.13322235643863678,
-0.1697860211133957,
0.012016033753752708,
-0.03133169934153557,
-0.229159414768219,
0.09245609492063522,
0.11694125086069107,
-0.14421869814395905,
0.10184361785650253,
0.11048277467489243,
-0.10826562345027924,
-0.12723946571350098,
0.08968431502580643,
0.19730891287326813,
-0.021937048062682152,
0.2335524559020996,
0.06330893188714981,
0.18040841817855835,
0.22575072944164276,
0.118891142308712,
-0.04834609106183052,
-0.02900739200413227,
-0.07034063339233398,
0.23154489696025848,
0.10033974796533585,
0.0008030986064113677,
-0.03787897899746895,
-0.20421865582466125,
0.2588641047477722,
-0.0982876569032669,
0.09050588309764862,
-0.1394687294960022,
0.20936943590641022,
0.20749850571155548,
0.16563372313976288,
0.16735775768756866,
-0.03728221729397774,
-0.047617584466934204,
0.06453526020050049,
0.08247727900743484,
-0.20794136822223663,
0.060646187514066696,
0.1522611379623413,
0.04234536364674568,
0.08728162199258804,
-0.1052456796169281,
0.1268717646598816,
0.06169157475233078,
-0.05488751828670502,
-0.12071771174669266,
0.1504678875207901,
-0.13810215890407562,
0.05306234210729599,
0.17299716174602509,
0.2403118908405304,
0.12993115186691284,
0.10192709416151047,
0.057998307049274445,
0.17801602184772491,
0.07398422807455063,
-0.06658413261175156,
0.00824389886111021,
-0.0752207487821579,
-0.15801246464252472,
-0.12128688395023346,
0.053763553500175476,
0.03638256713747978,
0.017066238448023796,
0.27164071798324585,
0.06282547116279602,
0.06577259302139282,
-0.1355547308921814,
-0.11450757831335068,
0.26266467571258545,
0.06311396509408951,
0.0024360266979783773,
0.02298884093761444,
0.1178065836429596,
-0.09858697652816772,
0.23065395653247833,
0.09126632660627365,
-0.04882503300905228,
0.035121213644742966,
-0.04865340143442154,
-0.05817437544465065,
0.16026873886585236,
0.056918807327747345,
0.05739659443497658,
0.14468854665756226,
0.14676016569137573,
0.03542599081993103,
0.24712137877941132,
-0.043103836476802826,
-0.1983523666858673,
-0.007276167627424002,
-0.0984584242105484,
0.018630871549248695,
0.12838827073574066,
-0.008689564652740955,
0.15185247361660004,
0.11615034192800522,
0.08141011744737625,
-0.18117132782936096,
0.14525721967220306,
-0.10897600650787354,
-0.16302388906478882,
0.16416244208812714,
-0.0023740269243717194,
-0.11982156336307526,
-0.12192226946353912,
-0.015315034426748753,
-0.0018537940923124552,
0.13309411704540253,
-0.003842016449198127,
-0.10116823762655258,
0.007404304575175047,
0.23827967047691345,
-0.10082507878541946,
0.004005250055342913,
-0.01592416502535343,
0.07174364477396011,
0.16544361412525177,
0.11241424083709717,
-0.10681048780679703,
0.026142895221710205,
-0.1067737489938736,
-0.1693851500749588,
-0.053273458033800125,
-0.0048162140883505344,
-0.17679981887340546,
0.12944720685482025,
-0.10789868980646133,
-0.02158563770353794,
-0.24887682497501373,
-0.03408210352063179,
0.11810595542192459,
0.03554486483335495,
0.043851640075445175,
0.07088940590620041,
0.2019519805908203,
0.18752485513687134,
0.03552106022834778,
0.0018941122107207775,
0.16019682586193085,
0.3401990532875061,
0.006939117331057787,
-0.09370557218790054,
-0.08664076775312424,
-0.1083328053355217,
0.03865287825465202,
-0.10395985096693039,
-0.03949088230729103,
-0.0825396180152893,
0.052564747631549835,
0.3944118618965149,
0.050405245274305344,
-0.12373816221952438,
0.0934542715549469,
-0.14636974036693573,
0.07278838753700256,
0.3011491596698761,
0.1750507801771164,
0.01861484721302986,
-0.12169069796800613,
-0.1698123812675476,
0.006429676897823811,
-0.22050409018993378,
0.10616640746593475,
0.20845775306224823,
0.2497245818376541,
0.04535417631268501,
0.09969351440668106,
-0.22505688667297363,
-0.07293424010276794,
0.1243501678109169,
-0.01555817574262619,
-0.12703947722911835,
0.033231377601623535,
-0.036622002720832825,
-0.13607823848724365,
-0.09362378716468811,
-0.03149423748254776,
-0.1337817907333374,
-0.112277090549469,
-0.13383589684963226,
0.1206805482506752,
-0.11011210083961487,
0.04847249388694763,
-0.017864612862467766,
-0.07297695428133011,
-0.13660843670368195,
-0.05533274635672569,
-0.14498181641101837,
-0.1265532672405243,
-0.00590765243396163,
-0.1016126424074173,
0.13870492577552795,
-0.06145026534795761,
-0.002863069763407111,
-0.017736341804265976,
0.0696181207895279,
-0.01550544798374176,
-0.07808297872543335,
-0.11916365474462509,
0.0005541115533560514,
0.05225800722837448,
-0.083684042096138,
0.13986167311668396,
-0.03949267044663429,
-0.05256185680627823,
0.08047571033239365,
-0.09693899005651474,
0.002685434650629759,
-0.12408392876386642,
-0.057707298547029495,
-0.24092814326286316,
0.14475424587726593,
-0.062064845114946365,
-0.0006155673181638122,
-0.012530196458101273,
-0.2570199966430664,
-0.06048870459198952,
-0.07594435662031174,
-0.033492859452962875,
-0.26290011405944824,
-0.1700938642024994,
0.012765313498675823,
-0.25390636920928955,
-0.3150891959667206,
-0.21323919296264648,
-0.025646481662988663,
-0.16641706228256226,
0.00690230680629611,
0.15023542940616608,
0.08895371854305267,
0.2127060741186142,
0.10427853465080261,
-0.016209306195378304,
-0.007504335604608059,
0.09098757058382034,
-0.07977736741304398,
0.23710253834724426,
-0.1763407438993454,
0.10203849524259567,
-0.06948833167552948,
0.129444420337677,
0.004675892181694508,
0.029792731627821922,
-0.1911405771970749,
-0.0638742595911026,
-0.04451757296919823,
-0.07035914808511734,
0.14237527549266815,
-0.22868221998214722,
-0.09732094407081604,
0.007110148202627897,
-0.03835965320467949,
0.13304124772548676,
-0.23556764423847198,
0.055244456976652145,
0.10854272544384003,
-0.06628198176622391,
-0.14090250432491302,
0.004377801436930895,
-0.03961844742298126,
0.13655251264572144,
-0.07231291383504868,
0.16130782663822174,
-0.09356936067342758,
-0.03840233013033867,
-0.15173864364624023,
0.18491509556770325,
0.0037105130031704903,
0.1346341371536255,
-0.21227216720581055,
-0.02317216247320175,
0.1506802886724472,
0.028851531445980072,
-0.06031976640224457,
0.19782613217830658,
0.009460823610424995,
-0.035944655537605286,
-0.00563338678330183,
-0.019587749615311623,
0.13391511142253876,
-0.13195334374904633,
0.17919635772705078,
-0.02757110446691513,
0.3575631380081177,
-0.014727743342518806,
0.07665443420410156,
-0.0867403894662857,
-0.01893572323024273,
-0.00729195075109601,
0.142800435423851,
-0.26884403824806213,
0.20595231652259827,
-0.1893201470375061,
-0.13285315036773682,
-0.056427858769893646,
-0.021197272464632988,
0.19987072050571442,
0.11991267651319504,
-0.17596381902694702,
0.1876380443572998,
-0.023160038515925407,
-0.010754459537565708,
0.053437817841768265,
-0.05239110067486763,
0.095125712454319,
-0.15606485307216644,
0.10590939968824387,
-0.010563160292804241,
-0.19800791144371033,
-0.023599375039339066,
-0.08975819498300552,
-0.1058848425745964,
-0.025675373151898384,
0.03907911106944084,
-0.03012128360569477,
-0.1757022887468338,
0.2056368738412857,
0.2038566619157791,
0.02189265936613083,
0.008669590577483177,
0.04967298358678818,
-0.07851921766996384,
-0.1338627189397812,
-0.06595238298177719,
-0.1043638363480568,
0.33151090145111084,
0.02827787771821022,
-0.2542489469051361,
-0.03057252988219261,
0.025308215990662575,
0.034346021711826324,
0.04239681363105774,
0.02510104700922966,
-0.014954110607504845,
0.050483789294958115,
-0.01403967197984457,
-0.03196215257048607,
-0.21369729936122894,
0.03905359283089638,
0.16557715833187103,
-0.18735767900943756,
-0.2052728235721588,
0.1477210968732834,
0.06586740165948868,
0.027145279571413994,
-0.0799449160695076,
0.16332164406776428,
-0.028866661712527275,
0.110199935734272,
0.11647634208202362,
0.05814407765865326,
0.149048313498497,
0.03311362862586975,
-0.16366270184516907,
-0.11635380983352661,
0.10961253196001053,
-0.048621613532304764,
0.01585749164223671,
0.11066215485334396,
0.10495419800281525,
0.07546350359916687,
0.24773535132408142,
-0.16984646022319794,
-0.040588244795799255,
-0.009880040772259235,
0.022501295432448387,
0.05976724997162819,
0.15240022540092468,
-0.10972344130277634,
-0.12966866791248322,
-0.015003358013927937,
0.14573340117931366,
0.0476241260766983,
0.1685212105512619,
0.1899305135011673,
-0.05324811115860939,
-0.06523440778255463,
-0.17595134675502777,
-0.1620773822069168,
0.1443231850862503,
0.02475610189139843,
0.12427963316440582,
-0.029066745191812515,
-0.0568031445145607,
0.11706381291151047,
0.09917370229959488,
-0.06716492772102356,
0.15992440283298492,
-0.033481862396001816,
-0.013911715708673,
0.13574008643627167,
0.07521367073059082,
-0.02985241264104843,
-0.07031865417957306,
-0.18083515763282776,
0.047148916870355606,
-0.06698515266180038,
0.06091216579079628,
0.11885162442922592,
0.01967356726527214,
0.0702817514538765,
0.09993424266576767,
-0.07145348191261292,
-0.0930856242775917,
0.10986238718032837,
0.1630319207906723,
-0.11255396157503128,
-0.008436119183897972,
0.11246933788061142,
-0.06158947944641113,
-0.005973061081022024,
0.09033141285181046,
-0.010836713947355747,
0.054748594760894775
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. and transepithelial potential difference has been described .One male developed severe progressive restrictive lung disease at age 45 years .A Druze woman age 24 years had progressive lung disease with chest CT findings of mainly cystic lung lesions and ground glass opacity . She experienced further deterioration in her pulmonary function and secondary pulmonary hypertension, and became oxygen dependent.An Amish boy age six years with pulmonary hypertension required supplemental oxygen .Systemic lupus erythematosus-like findings. An association between systemic lupus erythematosus (SLE) and prolidase deficiency has been described in at least ten individuals, including three of 23 individuals from northern Israel .This association, first described by Bissonnette et al in a female age 16 years, included Raynaud's phenomenon, photosensitivity, arthritis, nephritis (with segmental mesangial deposits of IgA, IgM, and C3), antinuclear antibodies 1:650, and a positive rheumatoid factor.Shrinath et al reported two cousins with prolidase deficiency and SLE: | [
-0.1484142541885376,
0.057601913809776306,
-0.01450206059962511,
-0.09180206060409546,
0.18268156051635742,
0.22991561889648438,
-0.12137999385595322,
-0.05742727592587471,
-0.1935209035873413,
-0.2889167368412018,
0.2203720062971115,
-0.002460728632286191,
0.20886187255382538,
-0.043671365827322006,
0.008330117911100388,
0.24091167747974396,
-0.0968051627278328,
-0.09326903522014618,
-0.08166918903589249,
-0.006272819358855486,
-0.1577552855014801,
-0.1536668986082077,
0.2919021248817444,
0.060949984937906265,
0.2670922577381134,
-0.1084776371717453,
-0.027689581736922264,
0.01883057877421379,
0.03761148080229759,
0.17814239859580994,
-0.0831906795501709,
-0.01926073431968689,
0.030244285240769386,
0.0035112432669848204,
0.1733216643333435,
-0.04562435671687126,
-0.2222200632095337,
-0.04669460654258728,
0.29520857334136963,
-0.10569141805171967,
-0.14343759417533875,
-0.01669134944677353,
0.02916470356285572,
0.16826139390468597,
0.04445008188486099,
-0.19140975177288055,
0.032715581357479095,
0.037410203367471695,
-0.26366040110588074,
0.048112768679857254,
0.33671629428863525,
-0.13711492717266083,
-0.04606781154870987,
-0.02753533609211445,
0.09931028634309769,
0.07000347226858139,
-0.025843072682619095,
0.15681710839271545,
-0.12306177616119385,
0.019669128581881523,
-0.0324835479259491,
-0.05738129839301109,
-0.051638536155223846,
-0.2526606321334839,
0.35717901587486267,
-0.08725649863481522,
0.11546497046947479,
0.09784495830535889,
-0.05544842779636383,
0.08015917986631393,
0.37418973445892334,
-0.027416188269853592,
0.15430811047554016,
-0.05165523663163185,
-0.23118174076080322,
0.08552251756191254,
0.03813035413622856,
-0.0728427842259407,
0.1484057605266571,
-0.15065300464630127,
-0.06842667609453201,
0.18042047321796417,
-0.044440850615501404,
0.22813557088375092,
-0.16195054352283478,
0.11691482365131378,
0.10281628370285034,
0.04301490634679794,
0.17018833756446838,
-0.07688083499670029,
0.028640586882829666,
-0.22129346430301666,
0.17044493556022644,
-0.0887083113193512,
-0.05449843406677246,
0.08003471046686172,
-0.09579212963581085,
-0.032116856426000595,
0.01749526336789131,
0.017781894654035568,
0.0027861117850989103,
0.11017783731222153,
-0.025153877213597298,
-0.06141634285449982,
0.041620414704084396,
-0.14303593337535858,
-0.11617081612348557,
-0.07376842200756073,
-0.1737275868654251,
0.04155568405985832,
0.34214508533477783,
0.033865541219711304,
-0.18382234871387482,
0.1752614974975586,
-0.09213872998952866,
-0.0864185020327568,
0.12505629658699036,
0.04848218336701393,
-0.19191405177116394,
-0.23824195563793182,
0.07477962225675583,
-0.08742870390415192,
0.007229635491967201,
-0.1800716370344162,
0.10532273352146149,
0.13888101279735565,
0.1174381673336029,
0.03720272332429886,
0.22381991147994995,
-0.01238042488694191,
0.06911478191614151,
-0.16985805332660675,
-0.0961090698838234,
-0.3268846869468689,
-0.021031176671385765,
-0.17475062608718872,
-0.13265007734298706,
-0.1295446753501892,
0.00276169809512794,
0.07737981528043747,
-0.03182154893875122,
-0.015248079784214497,
0.27707037329673767,
0.23373840749263763,
-0.07458364963531494,
-0.1303934007883072,
0.44485968351364136,
0.045004140585660934,
-0.0031062308698892593,
0.2476179450750351,
0.19556815922260284,
-0.27694568037986755,
0.4680827260017395,
-0.0642826184630394,
-0.11477182060480118,
0.041621074080467224,
-0.05041387304663658,
0.09574191272258759,
-0.21003392338752747,
0.04679735377430916,
0.2068997323513031,
0.11744346469640732,
0.0392974317073822,
-0.37760835886001587,
0.31371259689331055,
0.006552855018526316,
0.043920766562223434,
-0.10149325430393219,
0.2298588752746582,
-0.037912625819444656,
-0.18376798927783966,
-0.06625308841466904,
0.008844141848385334,
0.072945237159729,
-0.03886522725224495,
-0.008486717939376831,
-0.14535383880138397,
0.10166438668966293,
-0.05177177116274834,
0.0021625955123454332,
-0.00018581526819616556,
-0.05671701580286026,
-0.13835124671459198,
-0.23263128101825714,
0.13993115723133087,
-0.2854299545288086,
0.12743565440177917,
0.14621268212795258,
-0.17909914255142212,
0.000672377529554069,
0.12418288737535477,
0.01476986799389124,
-0.20497405529022217,
-0.2067706286907196,
0.10752520710229874,
-0.3151338994503021,
-0.03654574975371361,
-0.03414926677942276,
-0.017252501100301743,
0.024901842698454857,
0.27230969071388245,
-0.1504475176334381,
-0.017953205853700638,
0.05868874862790108,
0.05530407652258873,
0.12120937556028366,
-0.16716301441192627,
-0.04228481650352478,
-0.02837907150387764,
0.328511118888855,
0.1286252737045288,
0.13148318231105804,
-0.1057814508676529,
0.08881455659866333,
-0.034062616527080536,
0.03901296108961105,
-0.2541488707065582,
0.039854858070611954,
0.006342574488371611,
-0.0695904940366745,
-0.12331311404705048,
-0.11876660585403442,
-0.0646837055683136,
-0.3107626140117645,
-0.039039939641952515,
0.08906225115060806,
-0.08177826553583145,
0.07496986538171768,
0.01191994920372963,
0.050080858170986176,
-0.15669994056224823,
-0.005082356743514538,
0.15847451984882355,
0.12011720985174179,
-0.06941749155521393,
-0.19508574903011322,
0.03872711583971977,
0.17699773609638214,
0.1315215826034546,
0.10841129720211029,
-0.27305108308792114,
0.054744258522987366,
0.13982722163200378,
0.011548825539648533,
-0.262600839138031,
0.03847154974937439,
-0.19195370376110077,
0.019418368116021156,
-0.09517470747232437,
0.16303189098834991,
-0.019826266914606094,
-0.0028550608549267054,
0.019450491294264793,
-0.08131960034370422,
-0.4592795968055725,
-0.0971219539642334,
0.13276997208595276,
-0.1045961007475853,
0.10423009842634201,
0.06196579709649086,
0.08050332218408585,
0.12517933547496796,
0.038117263466119766,
0.038573890924453735,
-0.02400633879005909,
-0.0789889320731163,
-0.1402260959148407,
0.14411182701587677,
-0.06968270987272263,
-0.23916186392307281,
0.0965479165315628,
0.1274905502796173,
0.2624647617340088,
0.08829452097415924,
-0.03310936689376831,
-0.05846076086163521,
-0.13991695642471313,
-0.028617307543754578,
0.1101253479719162,
-0.12376108020544052,
0.1688152402639389,
-0.10478835552930832,
-0.21833959221839905,
0.028321294113993645,
0.25454309582710266,
0.09445478767156601,
0.042465921491384506,
0.03283433988690376,
-0.06545965373516083,
-0.02977997064590454,
0.08430182188749313,
0.019179699942469597,
-0.27581432461738586,
-0.12274737656116486,
0.061945151537656784,
0.013295810669660568,
-0.031864605844020844,
-0.1481432318687439,
0.08775600045919418,
0.03932451084256172,
0.18767878413200378,
0.08718755096197128,
-0.05530424788594246,
0.025321021676063538,
0.006577782798558474,
0.11427593976259232,
0.2464870661497116,
0.25639352202415466,
-0.11668113619089127,
0.15006057918071747,
-0.08197154104709625,
-0.036681320518255234,
-0.009548281319439411,
-0.10401010513305664,
0.0006108122761361301,
0.01853063330054283,
-0.2150471806526184,
0.0139652444049716,
0.17359474301338196,
0.10487798601388931,
0.2592400908470154,
-0.06158929690718651,
0.10195107758045197,
0.11045288294553757,
0.1303073912858963,
0.30729907751083374,
-0.12243612110614777,
0.09466106444597244,
-0.034664884209632874,
0.1557200402021408,
0.07398925721645355,
-0.0964997336268425,
-0.07054683566093445,
-0.09574934840202332,
-0.05925115570425987,
-0.0642596110701561,
0.22888730466365814,
0.04292140528559685,
0.01814255304634571,
-0.042010802775621414,
0.0443708561360836,
-0.13706879317760468,
0.09500584751367569,
-0.1764209270477295,
0.09278669208288193,
-0.01124749518930912,
-0.04335558041930199,
0.18092909455299377,
0.10995671153068542,
-0.10534760355949402,
-0.15758033096790314,
-0.15171366930007935,
0.03969915211200714,
-0.12885132431983948,
0.09590635448694229,
0.07580205053091049,
-0.11227984726428986,
0.03499072045087814,
0.10091162472963333,
-0.17465567588806152,
-0.1057904064655304,
0.20777642726898193,
0.2664291560649872,
0.06949068605899811,
0.25483447313308716,
0.293241411447525,
-0.0016304957680404186,
0.12275898456573486,
0.0948350802063942,
-0.08324277400970459,
0.060848385095596313,
-0.055385980755090714,
0.3312225937843323,
-0.007762821391224861,
0.05618339776992798,
0.012525597587227821,
-0.4102090001106262,
0.21454304456710815,
-0.1646026372909546,
-0.011428063735365868,
-0.23541483283042908,
0.21451756358146667,
0.1342717856168747,
0.20169785618782043,
0.17955289781093597,
-0.009466416202485561,
-0.24678610265254974,
0.16522474586963654,
-0.12836122512817383,
-0.26270899176597595,
0.29583898186683655,
0.10309671610593796,
0.09285861253738403,
0.19336488842964172,
-0.21059516072273254,
0.1650107055902481,
-0.09090426564216614,
-0.08743474632501602,
-0.4094177484512329,
-0.04022165760397911,
0.009096316061913967,
-0.1631511151790619,
0.18785592913627625,
0.24089141190052032,
0.17581981420516968,
0.07844424992799759,
-0.03200841695070267,
-0.002570243552327156,
0.03815165162086487,
-0.07230386137962341,
-0.014561296440660954,
-0.0372871570289135,
-0.1243811845779419,
-0.16531670093536377,
-0.005811881273984909,
0.05310516059398651,
-0.1648825705051422,
0.1978108286857605,
0.12245698273181915,
-0.13092263042926788,
-0.1904219537973404,
-0.053833380341529846,
0.16235072910785675,
-0.057287078350782394,
-0.03895869478583336,
-0.06992743909358978,
0.14079812169075012,
-0.1718355119228363,
0.2287268042564392,
-0.04756363108754158,
0.13909460604190826,
0.2378440797328949,
-0.10510805249214172,
0.05130018666386604,
0.18947795033454895,
0.09365241974592209,
0.03639490529894829,
0.12744225561618805,
0.2606833577156067,
0.10476164519786835,
0.33635321259498596,
0.11792567372322083,
-0.1701626032590866,
-0.08468881249427795,
0.016489343717694283,
0.0967005044221878,
0.008141400292515755,
0.016455719247460365,
0.03009255975484848,
0.11059345304965973,
0.009041201323270798,
-0.28979286551475525,
0.18842937052249908,
-0.06618094444274902,
-0.28234773874282837,
-0.01491448376327753,
0.08265054225921631,
-0.1395406872034073,
-0.057921212166547775,
0.09779886901378632,
-0.12806390225887299,
0.11506254225969315,
0.054256122559309006,
-0.08534573763608932,
0.10411468148231506,
0.29056790471076965,
-0.08694488555192947,
-0.13678953051567078,
-0.04275292903184891,
0.16803251206874847,
0.14701786637306213,
0.11217092722654343,
0.10218719393014908,
-0.1478167623281479,
-0.019607065245509148,
-0.12804289162158966,
0.0764143168926239,
0.05174989253282547,
-0.11090560257434845,
0.04289830103516579,
0.03498898819088936,
0.08961089700460434,
-0.1969667673110962,
0.12537838518619537,
0.15969136357307434,
0.06574109941720963,
-0.014319812878966331,
0.04424695298075676,
0.1854322850704193,
0.014544691890478134,
0.16007685661315918,
-0.03225265443325043,
0.038978587836027145,
0.4036470651626587,
-0.011777793988585472,
-0.15676306188106537,
-0.00840253196656704,
-0.12287066131830215,
0.15200303494930267,
-0.02567971684038639,
0.04971746355295181,
-0.1391834318637848,
0.01640564203262329,
0.3025902807712555,
-0.012060262262821198,
-0.06514344364404678,
-0.013400663621723652,
-0.16533207893371582,
0.1048009917140007,
0.31682464480400085,
0.1718650758266449,
-0.07702893763780594,
-0.04516364634037018,
-0.21428662538528442,
-0.13280919194221497,
-0.06353971362113953,
0.0957472026348114,
0.28929147124290466,
0.3266620635986328,
-0.054019492119550705,
0.1798621267080307,
-0.21704722940921783,
-0.11838160455226898,
-0.012759044766426086,
-0.03156746178865433,
-0.14503856003284454,
0.05267908424139023,
-0.25362685322761536,
0.01658504270017147,
-0.1695776879787445,
-0.14001472294330597,
-0.10360722988843918,
-0.0694199651479721,
0.07190239429473877,
0.22457200288772583,
-0.18544286489486694,
0.13162599503993988,
0.1250307559967041,
0.07257644832134247,
0.058323249220848083,
-0.0008044911082834005,
0.013058353215456009,
-0.03036590665578842,
-0.036479439586400986,
-0.04796675220131874,
-0.10841311514377594,
0.037753768265247345,
0.041717689484357834,
-0.08671563863754272,
0.0024381252005696297,
-0.0978400707244873,
0.06321509182453156,
-0.10596025735139847,
-0.018085243180394173,
-0.026943085715174675,
0.046846695244312286,
0.03557504713535309,
-0.0759134367108345,
-0.03921527788043022,
0.005134220700711012,
0.07111942768096924,
-0.11069491505622864,
-0.15205223858356476,
0.07727720588445663,
-0.10204195976257324,
0.02736959233880043,
-0.010349445044994354,
0.06892576813697815,
-0.17414416372776031,
-0.28554078936576843,
-0.13617971539497375,
-0.08349824696779251,
0.0704336017370224,
-0.2543429732322693,
-0.13261055946350098,
0.07139967381954193,
-0.30381011962890625,
0.02697218395769596,
-0.24080437421798706,
-0.01689099706709385,
-0.07333163172006607,
-0.06010735407471657,
0.07101433724164963,
0.27988767623901367,
0.10106071829795837,
0.11616846174001694,
-0.262052983045578,
0.20718596875667572,
0.034182850271463394,
0.002162441611289978,
0.1836741715669632,
-0.2069547027349472,
0.1028813049197197,
-0.19444474577903748,
0.2085774838924408,
0.05552695319056511,
0.034681398421525955,
-0.09069474786520004,
-0.14615881443023682,
-0.015769770368933678,
-0.1751803755760193,
-0.008092503063380718,
-0.07044007629156113,
-0.2540886402130127,
-0.01486386451870203,
0.09190329164266586,
0.21099115908145905,
-0.1367764174938202,
0.24918709695339203,
-0.14523263275623322,
-0.06060948967933655,
-0.1274554431438446,
0.15483854711055756,
-0.10334579646587372,
0.17682941257953644,
-0.18691599369049072,
-0.009660891257226467,
-0.22639718651771545,
-0.1974184215068817,
-0.12369856983423233,
0.1712433099746704,
0.03466121852397919,
-0.02717903070151806,
-0.21103130280971527,
-0.13269934058189392,
0.45606744289398193,
0.022149715572595596,
-0.08215665817260742,
0.2318568080663681,
0.05390194430947304,
-0.11805226653814316,
0.002798650646582246,
-0.12210940569639206,
-0.0018412208883091807,
-0.17517420649528503,
0.1216513141989708,
0.0348549410700798,
0.3251798748970032,
0.1526554673910141,
0.07001008838415146,
-0.22267909348011017,
-0.05957581475377083,
0.06846142560243607,
0.18991543352603912,
-0.12476672977209091,
0.16944828629493713,
-0.12634550034999847,
-0.24509087204933167,
-0.0677083358168602,
0.06303869932889938,
0.08613881468772888,
0.06679502129554749,
0.034776706248521805,
-0.027044108137488365,
-0.17744003236293793,
-0.15805843472480774,
0.0005529060726985335,
-0.015406282618641853,
0.05627945065498352,
-0.14486415684223175,
0.20629097521305084,
-0.06842884421348572,
-0.17004892230033875,
0.3264492452144623,
-0.023471027612686157,
-0.41842082142829895,
-0.057411085814237595,
0.029386738315224648,
0.04682096093893051,
-0.006783348973840475,
0.3197380602359772,
0.15465980768203735,
0.11613205820322037,
0.04682666435837746,
0.03887433558702469,
0.04246264323592186,
0.01001387182623148,
-0.2250773161649704,
-0.1069023385643959,
0.28407493233680725,
-0.042522307485342026,
-0.23480430245399475,
0.09674742072820663,
0.047442056238651276,
0.06045995280146599,
0.1529395878314972,
-0.11110814660787582,
0.07171522825956345,
0.09329114854335785,
-0.06149933859705925,
-0.07221624255180359,
-0.10204998403787613,
0.1303708553314209,
-0.029323238879442215,
-0.25154390931129456,
-0.12944069504737854,
0.11259015649557114,
0.05880666524171829,
0.06380530446767807,
-0.08927153795957565,
0.03898449242115021,
-0.0008943314896896482,
-0.0023448746651411057,
-0.06239587441086769,
0.1577354222536087,
0.14817416667938232,
0.06492958962917328,
-0.06030801683664322,
0.05927804484963417,
0.009558137506246567,
0.01748739741742611,
0.0082372622564435,
-0.07958835363388062,
0.31732377409935,
-0.04168032854795456,
0.1784648448228836,
-0.21977956593036652,
-0.06065182387828827,
-0.023326275870203972,
0.07644268870353699,
0.2215636819601059,
0.28571176528930664,
0.03926672041416168,
-0.009032479487359524,
-0.01752707175910473,
-0.027107391506433487,
-0.09602818638086319,
0.06949090957641602,
0.14759573340415955,
-0.06460202485322952,
-0.08985661715269089,
-0.2710721492767334,
0.03077864646911621,
0.26827386021614075,
-0.15292377769947052,
0.00743517279624939,
0.019134793430566788,
-0.1561579704284668,
0.16223455965518951,
0.1833471804857254,
-0.2880692183971405,
0.12938283383846283,
-0.002340927254408598,
0.0027054385282099247,
0.0822598785161972,
0.1197655200958252,
-0.05076148733496666,
-0.04735586792230606,
-0.2081429809331894,
0.03801421821117401,
-0.13023948669433594,
0.15951290726661682,
0.34675106406211853,
-0.019019989296793938,
-0.05243540555238724,
0.11354421079158783,
-0.13822990655899048,
-0.16964340209960938,
0.07260782271623611,
0.19469663500785828,
-0.11838313192129135,
-0.08778004348278046,
0.01665574684739113,
0.09507573395967484,
0.08366820216178894,
-0.0759839341044426,
-0.03491288423538208,
-0.0380597785115242
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. ) and prolidase deficiency has been described in at least ten individuals, including three of 23 individuals from northern Israel .This association, first described by Bissonnette et al in a female age 16 years, included Raynaud's phenomenon, photosensitivity, arthritis, nephritis (with segmental mesangial deposits of IgA, IgM, and C3), antinuclear antibodies 1:650, and a positive rheumatoid factor.Shrinath et al reported two cousins with prolidase deficiency and SLE:One had a malar facial rash, joint swellings, thrombocytopenia, neutropenia, proteinuria, pericarditis, hypocomplementemia, positive antinuclear antibody test (ANA), and strongly positive anti-dsDNA;The other had recurrent mouth ulcers, a malar rash, thrombocytopenia, neutropenia, positive ANA, positive anti-dsDNA, and positive pANCA.A boy age 11 years had photosensitivity, malar erythema, and a positive ANA of 1:40 .A boy | [
-0.009365051984786987,
-0.006722483318299055,
0.05688304454088211,
-0.17244258522987366,
0.026324821636080742,
0.22397607564926147,
-0.29230934381484985,
-0.08092586696147919,
-0.16682696342468262,
-0.3331160247325897,
0.22045204043388367,
-0.17757947742938995,
0.11096662282943726,
-0.17412228882312775,
-0.07664866745471954,
0.17594583332538605,
0.00949142687022686,
-0.005952817387878895,
-0.0464031882584095,
-0.04580926150083542,
0.0010007377713918686,
-0.18706224858760834,
0.3197413980960846,
0.24688595533370972,
0.17453160881996155,
-0.13661623001098633,
-0.010141286067664623,
0.021422067657113075,
0.10154183208942413,
0.21098662912845612,
0.03338726609945297,
-0.18352921307086945,
-0.04215991124510765,
0.15031030774116516,
0.027568701654672623,
0.010838649235665798,
-0.2812879979610443,
-0.08001546561717987,
0.3001382350921631,
0.04055437073111534,
-0.0935262069106102,
-0.03220425918698311,
0.12386107444763184,
0.24960607290267944,
-0.08074009418487549,
-0.2272169589996338,
0.002019282663241029,
-0.04733595624566078,
-0.12575823068618774,
-0.053478047251701355,
0.1878114938735962,
0.005247087217867374,
-0.14621803164482117,
0.13263745605945587,
0.11155007034540176,
0.05664873495697975,
-0.0262408759444952,
0.15603938698768616,
-0.01840309612452984,
0.0045564910396933556,
-0.004455624148249626,
0.07267659902572632,
-0.019165705889463425,
-0.16228024661540985,
0.3193107545375824,
-0.13615566492080688,
0.1860727071762085,
0.18362323939800262,
-0.1648748815059662,
-0.023534543812274933,
0.30522531270980835,
-0.12787991762161255,
0.14145666360855103,
-0.027566036209464073,
-0.018312402069568634,
0.25099048018455505,
0.10296683013439178,
-0.05425199121236801,
0.1587977111339569,
-0.18490338325500488,
-0.04475930705666542,
0.06725237518548965,
-0.1328568011522293,
0.26578783988952637,
-0.04706399887800217,
0.08398028463125229,
0.13368304073810577,
0.06577973812818527,
0.030894367024302483,
-0.15200155973434448,
0.0008811651496216655,
-0.22477149963378906,
-0.11130283772945404,
-0.031193841248750687,
-0.010706302709877491,
-0.03345079347491264,
-0.15387867391109467,
-0.017711538821458817,
0.011167346499860287,
0.06758033484220505,
0.036689527332782745,
0.08735369145870209,
-0.08523900806903839,
-0.13647900521755219,
-0.1405704915523529,
-0.21097993850708008,
-0.1677844375371933,
-0.1100071370601654,
-0.21397344768047333,
0.21556071937084198,
0.3715093731880188,
0.04649908468127251,
-0.11279084533452988,
0.14330746233463287,
-0.08653409779071808,
-0.05739659070968628,
0.06403790414333344,
-0.01071882527321577,
-0.17949098348617554,
-0.2240987867116928,
0.06853064149618149,
-0.23822107911109924,
0.024210471659898758,
-0.1801348775625229,
0.10972317308187485,
0.07127290964126587,
-0.017729120329022408,
-0.21514517068862915,
0.15107658505439758,
-0.02202676422894001,
0.006967882160097361,
-0.07859444618225098,
-0.10907427966594696,
-0.35702618956565857,
0.14109401404857635,
-0.24154558777809143,
-0.056133728474378586,
-0.1710045039653778,
0.0714983195066452,
0.01125742681324482,
-0.006452317349612713,
-0.11787239462137222,
0.255653977394104,
0.3159961402416229,
-0.1413104087114334,
-0.19881194829940796,
0.35748445987701416,
-0.06399372965097427,
-0.05608287453651428,
0.20318934321403503,
0.15315142273902893,
-0.3457513451576233,
0.5539905428886414,
-0.03416591137647629,
-0.31241196393966675,
0.04964742437005043,
0.06111612543463707,
0.07968122512102127,
-0.3409739136695862,
0.04263126850128174,
0.26032689213752747,
0.06510943919420242,
0.0701928585767746,
-0.25084322690963745,
0.25012466311454773,
-0.07022169977426529,
0.08821926265954971,
-0.21868136525154114,
0.2779281437397003,
0.043450068682432175,
-0.16590175032615662,
-0.09597079455852509,
0.05552568659186363,
-0.04176868498325348,
0.22452276945114136,
0.00631784088909626,
-0.22481225430965424,
-0.045648980885744095,
-0.06167980283498764,
-0.0771646574139595,
-0.06863328069448471,
0.04355693608522415,
-0.11113933473825455,
-0.2906312942504883,
0.10254105180501938,
-0.37530121207237244,
-0.007353185210376978,
0.11963130533695221,
-0.0495707206428051,
0.04763733968138695,
0.14700762927532196,
-0.005398379173129797,
-0.1393679678440094,
-0.35063108801841736,
0.0021383301354944706,
-0.14680354297161102,
-0.08579126000404358,
-0.005049920175224543,
-0.010930593125522137,
0.03721834719181061,
0.1983003169298172,
-0.021636296063661575,
-0.14700859785079956,
-0.08609125018119812,
0.111565962433815,
0.21160760521888733,
-0.12198742479085922,
-0.005809688940644264,
-0.0500703863799572,
0.2744640111923218,
0.16215111315250397,
0.0064857276156544685,
-0.058717843145132065,
0.27678370475769043,
-0.055428680032491684,
0.060988035053014755,
-0.19591982662677765,
-0.08423711359500885,
0.23564113676548004,
0.00445188581943512,
-0.036844734102487564,
-0.1393691897392273,
-0.16348916292190552,
-0.33944907784461975,
-0.021155495196580887,
0.05667438358068466,
-0.06594949215650558,
-0.1502206176519394,
-0.04784874990582466,
0.05931483581662178,
-0.11696048825979233,
0.08540993183851242,
0.07242079824209213,
0.14187464118003845,
-0.17749792337417603,
-0.1806337982416153,
0.028843624517321587,
0.17496460676193237,
0.08094223588705063,
0.24280481040477753,
-0.11506424844264984,
0.16344794631004333,
0.13679376244544983,
-0.039001304656267166,
-0.22054196894168854,
-0.04447454214096069,
-0.11891375482082367,
-0.10820616036653519,
0.12891964614391327,
0.16454410552978516,
0.07088102400302887,
-0.016812250018119812,
-0.07448592782020569,
-0.17149989306926727,
-0.5073041915893555,
-0.03009623847901821,
0.20010268688201904,
-0.10738059133291245,
0.007134287618100643,
0.005912631284445524,
0.06408373266458511,
0.1993483006954193,
-0.0022954789455980062,
-0.08857851475477219,
-0.025019625201821327,
0.002071101451292634,
-0.21230435371398926,
0.025844773277640343,
0.03238854184746742,
-0.19460663199424744,
-0.025274107232689857,
0.16589103639125824,
0.1807391494512558,
0.1051592230796814,
0.012423569336533546,
-0.06481057405471802,
-0.10275211185216904,
0.017959412187337875,
0.20643751323223114,
-0.23557229340076447,
0.04826511815190315,
-0.17535291612148285,
-0.2423887997865677,
-0.03538471832871437,
0.35896947979927063,
0.05297190323472023,
0.11069291085004807,
0.11993948370218277,
0.04502485319972038,
-0.06284234672784805,
0.009213616140186787,
0.24198858439922333,
-0.15892577171325684,
0.01284480094909668,
0.0047767627984285355,
-0.09146842360496521,
0.006268489174544811,
-0.20753274857997894,
0.19104889035224915,
0.14095662534236908,
0.22162838280200958,
0.1642465442419052,
-0.1225239485502243,
0.07367592304944992,
-0.08715824037790298,
0.08616343140602112,
0.17110027372837067,
0.2941349446773529,
-0.028651250526309013,
0.26771098375320435,
-0.27925658226013184,
-0.05161143094301224,
-0.03356228396296501,
-0.186281219124794,
0.03360565006732941,
0.0691140741109848,
-0.14246255159378052,
0.028932619839906693,
0.20494399964809418,
0.09355625510215759,
0.34499385952949524,
-0.12266047298908234,
0.0676228478550911,
0.09169735014438629,
0.05157266557216644,
0.18966229259967804,
-0.19995048642158508,
0.05083496868610382,
-0.11327598989009857,
0.19054262340068817,
0.1807508021593094,
0.04129951074719429,
-0.09220337122678757,
-0.230208620429039,
-0.10156762599945068,
0.04112792760133743,
0.22912763059139252,
-0.09250825643539429,
-0.026886770501732826,
-0.2794613838195801,
-0.01848255842924118,
-0.24005025625228882,
0.016448864713311195,
-0.18614831566810608,
0.049125172197818756,
-0.12554030120372772,
0.10365066677331924,
0.11201487481594086,
0.07318352162837982,
-0.08648526668548584,
-0.14301711320877075,
-0.10990354418754578,
0.010276536457240582,
-0.016440343111753464,
0.11363010108470917,
0.02515225112438202,
-0.022288445383310318,
-0.02443334087729454,
0.11850123107433319,
-0.16186325252056122,
-0.06870663166046143,
0.2626006603240967,
0.0878521203994751,
-0.003148298477753997,
0.25508779287338257,
0.10211610794067383,
0.09454508125782013,
0.028094198554754257,
0.03404044732451439,
0.029312901198863983,
-0.11858846247196198,
0.12811660766601562,
0.39886608719825745,
-0.04965176060795784,
-0.026342598721385002,
0.1081579178571701,
-0.3034919500350952,
0.30990248918533325,
-0.20104822516441345,
0.054783061146736145,
-0.19608530402183533,
0.28213101625442505,
0.09797949343919754,
0.08749694377183914,
0.14773418009281158,
0.19289666414260864,
-0.22835926711559296,
0.02268570102751255,
-0.062043871730566025,
-0.19519488513469696,
0.3302080035209656,
0.17897950112819672,
0.16802488267421722,
0.1004529520869255,
-0.08741921931505203,
0.14923226833343506,
-0.15366578102111816,
-0.04619408771395683,
-0.3210647702217102,
-0.09335404634475708,
-0.08148029446601868,
-0.16242721676826477,
0.01857173629105091,
0.20514564216136932,
0.19050775468349457,
0.07640568166971207,
-0.023482993245124817,
-0.05925443023443222,
0.053646162152290344,
-0.13125143945217133,
0.007477818056941032,
-0.09533700346946716,
-0.1411174088716507,
-0.18792018294334412,
-0.025577707216143608,
0.08204285055398941,
-0.09433526545763016,
0.12972639501094818,
0.2191661298274994,
-0.12333764880895615,
-0.1620359569787979,
-0.0897221565246582,
0.1705465167760849,
-0.06194799765944481,
-0.00873467605561018,
-0.02399441972374916,
0.13300225138664246,
-0.1179986298084259,
0.256390243768692,
0.11425374448299408,
0.20374734699726105,
0.13454195857048035,
-0.09767582267522812,
0.14096370339393616,
0.11830152571201324,
0.051880933344364166,
0.11295083165168762,
-0.010549166239798069,
0.39026397466659546,
0.004373268224298954,
0.2730081081390381,
0.22122348845005035,
-0.2739265561103821,
-0.010136419907212257,
-0.022802069783210754,
0.14982441067695618,
0.0053932988084852695,
0.05597122386097908,
0.0940854623913765,
0.06538432836532593,
0.10600559413433075,
-0.25356635451316833,
0.12822353839874268,
0.028505969792604446,
-0.14986495673656464,
-0.2472413182258606,
0.07205300778150558,
-0.08174970746040344,
-0.038667842745780945,
0.0017998755211010575,
-0.16907750070095062,
0.0524492971599102,
0.14656545221805573,
-0.18124179542064667,
0.11378289014101028,
0.28388673067092896,
-0.08311881870031357,
-0.1525486409664154,
0.02478891797363758,
0.03562465310096741,
0.14116926491260529,
0.03369859978556633,
0.11501237004995346,
-0.21913407742977142,
-0.10635010898113251,
-0.09654246270656586,
0.2590154707431793,
0.09649259597063065,
-0.009663818404078484,
0.0807269811630249,
0.06015627086162567,
0.09481361508369446,
-0.19995515048503876,
0.1728426069021225,
-0.01612316444516182,
-0.09478730708360672,
-0.19091734290122986,
-0.007955019362270832,
0.13418139517307281,
-0.09384714066982269,
0.23095810413360596,
-0.007766985800117254,
0.013272995129227638,
0.3527913987636566,
-0.05039201304316521,
-0.12367215007543564,
-0.09355420619249344,
-0.11110049486160278,
0.16304777562618256,
-0.016515834257006645,
0.09581812471151352,
-0.059120409190654755,
0.16147755086421967,
0.07073505967855453,
0.017281584441661835,
0.03672762215137482,
-0.05532265827059746,
0.05687694996595383,
0.1676434725522995,
0.15996678173542023,
0.20468337833881378,
-0.148043692111969,
0.06504334509372711,
-0.3978689908981323,
-0.0321175754070282,
-0.11601932346820831,
0.18381503224372864,
0.2431143969297409,
0.2731606066226959,
-0.0761847272515297,
0.16076543927192688,
-0.23213084042072296,
-0.11395064741373062,
0.01858746074140072,
-0.08516865223646164,
-0.3140834867954254,
-0.04432925954461098,
-0.06912688910961151,
0.08054719120264053,
-0.22910729050636292,
-0.006565905641764402,
-0.0507938489317894,
-0.16518592834472656,
0.19031506776809692,
0.26448556780815125,
-0.25656670331954956,
0.08345106244087219,
0.13333791494369507,
0.11416934430599213,
0.04199327528476715,
0.24756470322608948,
0.05476444214582443,
0.09631373733282089,
-0.16391737759113312,
-0.01690128818154335,
0.004896606784313917,
-0.07798007875680923,
0.0920964926481247,
0.011002912186086178,
-0.10187928378582001,
-0.1145736575126648,
0.1162332221865654,
0.022638488560914993,
0.0011355830356478691,
-0.17584744095802307,
0.07978428155183792,
0.004226041957736015,
-0.13881509006023407,
-0.0050191027112305164,
0.0034174774773418903,
-0.03260967507958412,
-0.15933263301849365,
-0.12249894440174103,
0.011521543376147747,
-0.07301954925060272,
-0.007884102873504162,
-0.022969022393226624,
0.05468810349702835,
-0.3052627742290497,
-0.24019458889961243,
-0.2315884381532669,
-0.15208598971366882,
0.148188516497612,
0.032677583396434784,
-0.1321115642786026,
-0.007777795661240816,
-0.12186827510595322,
0.05913133546710014,
-0.047655802220106125,
0.009482966735959053,
-0.2416635900735855,
-0.18070220947265625,
0.05318788066506386,
0.1832979917526245,
-0.028714660555124283,
-0.053885478526353836,
-0.22866246104240417,
0.1036687046289444,
-0.09334272146224976,
-0.054304562509059906,
0.17848174273967743,
-0.14614760875701904,
-0.056380342692136765,
-0.09002560377120972,
0.1835520714521408,
0.14205782115459442,
0.09588070213794708,
0.018107684329152107,
-0.09270060807466507,
-0.12684112787246704,
0.02204485610127449,
0.03695828095078468,
0.07005129009485245,
-0.2817170321941376,
0.05574147775769234,
0.23113560676574707,
0.18179725110530853,
-0.0009947448270395398,
0.4827994108200073,
-0.23034194111824036,
0.2011411339044571,
-0.09264779835939407,
0.1975911557674408,
-0.22557313740253448,
0.11134235560894012,
0.06578391045331955,
-0.03725007176399231,
-0.172227680683136,
-0.19909022748470306,
-0.23528043925762177,
0.2054235339164734,
0.11692260205745697,
-0.013280786573886871,
-0.09186511486768723,
-0.09905526787042618,
0.4384462833404541,
0.19847001135349274,
-0.08784733712673187,
0.14090976119041443,
-0.014977608807384968,
-0.05734949931502342,
-0.019190706312656403,
-0.08880665898323059,
0.010384987108409405,
-0.08403735607862473,
0.10240387916564941,
0.041068293154239655,
0.35446083545684814,
0.11852645874023438,
0.029788115993142128,
-0.2094539850950241,
-0.0923873782157898,
0.021856196224689484,
0.07745568454265594,
-0.04119342938065529,
0.243376687169075,
-0.06123742088675499,
-0.18284934759140015,
0.10399655997753143,
0.08583329617977142,
0.1652003675699234,
0.028523162007331848,
0.12066872417926788,
-0.16337601840496063,
-0.2334226816892624,
-0.04591357335448265,
-0.05800652876496315,
-0.04087236896157265,
0.05267871916294098,
-0.2881544828414917,
0.1371130347251892,
-0.08554747700691223,
-0.1302458792924881,
0.31553494930267334,
0.04136069118976593,
-0.23603413999080658,
0.02374914474785328,
-0.019855691120028496,
0.08466333150863647,
0.03186092525720596,
0.21744389832019806,
0.06819473952054977,
-0.006516383029520512,
-0.03301079571247101,
-0.054628077894449234,
0.07504575699567795,
0.03780091181397438,
-0.21975867450237274,
-0.027340445667505264,
0.27517077326774597,
-0.07301893830299377,
-0.14070573449134827,
0.19579140841960907,
0.10901828110218048,
0.0850682333111763,
0.21239978075027466,
-0.13399338722229004,
0.06842882186174393,
0.2015148550271988,
-0.04887160286307335,
-0.17481662333011627,
-0.0228487029671669,
0.06417780369520187,
-0.011493667028844357,
-0.208535298705101,
-0.07422109693288803,
0.12247513234615326,
0.06466889381408691,
0.018840370699763298,
-0.09080852568149567,
-0.05684811249375343,
0.01862102746963501,
-0.09498779475688934,
-0.06745465844869614,
0.15503054857254028,
0.10922299325466156,
0.11307369917631149,
-0.043357301503419876,
0.01914818584918976,
-0.03231068328022957,
0.10240616649389267,
-0.11770946532487869,
-0.15788356959819794,
0.37225398421287537,
0.059588123112916946,
-0.0033418734092265368,
-0.16694879531860352,
-0.006668085232377052,
0.016308361664414406,
0.11415084451436996,
0.223906472325325,
0.22432459890842438,
0.05984794348478317,
-0.03787781670689583,
-0.025570489466190338,
-0.013274410739541054,
-0.22401422262191772,
0.05739409849047661,
0.11506534367799759,
-0.2243058681488037,
-0.23988237977027893,
-0.3190188407897949,
0.18001136183738708,
0.15385647118091583,
-0.16924573481082916,
0.033091284334659576,
0.10336542129516602,
-0.17039701342582703,
0.15997980535030365,
0.24148844182491302,
-0.2756142020225525,
0.1533220112323761,
-0.017988616600632668,
0.07901579141616821,
0.007804045919328928,
0.18845441937446594,
-0.11781681329011917,
-0.02602619305253029,
-0.05169801041483879,
-0.02025524713099003,
0.03478527441620827,
0.19930146634578705,
0.3628769516944885,
-0.05933969467878342,
0.13381993770599365,
0.14585527777671814,
-0.09559694677591324,
-0.20517367124557495,
-0.08555372804403305,
0.20910075306892395,
-0.09102695435285568,
-0.12346024811267853,
0.14695115387439728,
-0.015843404456973076,
0.1253225952386856,
-0.1720322072505951,
-0.011151994578540325,
-0.07633848488330841
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. prolidase deficiency and SLE:One had a malar facial rash, joint swellings, thrombocytopenia, neutropenia, proteinuria, pericarditis, hypocomplementemia, positive antinuclear antibody test (ANA), and strongly positive anti-dsDNA;The other had recurrent mouth ulcers, a malar rash, thrombocytopenia, neutropenia, positive ANA, positive anti-dsDNA, and positive pANCA.A boy age 11 years had photosensitivity, malar erythema, and a positive ANA of 1:40 .A boy age six years diagnosed with SLE was treated for two years with steroids and azathioprine, with amelioration of the immunologic abnormalities but worsening of the skin lesions .A male age 25 years had bilateral and symmetric synovitis affecting hands, elbows, and knees, a positive rheumatoid factor (516 IU/mL) and homogeneous ANA (1:640), and low C4 and CH50 (0.07 g/L and 61%) . He fulfilled the American College of Rheumatology ( | [
-0.13430935144424438,
-0.007685663644224405,
0.0585363544523716,
-0.19781839847564697,
-0.06510888785123825,
0.2807817757129669,
-0.24267210066318512,
-0.07818018645048141,
-0.09981736540794373,
-0.36336442828178406,
0.15012766420841217,
-0.16267521679401398,
0.1356704980134964,
-0.2097669243812561,
-0.22434021532535553,
0.2643279433250427,
0.12237529456615448,
0.06003168970346451,
-0.04285287484526634,
-0.02395784668624401,
0.17177145183086395,
-0.1368562877178192,
0.23927217721939087,
0.2017907202243805,
0.22343508899211884,
-0.19230052828788757,
0.008690664544701576,
0.02564862184226513,
0.04586873948574066,
0.23376862704753876,
0.08221178501844406,
-0.2910258173942566,
-0.06419872492551804,
0.10675634443759918,
0.004265390802174807,
0.08420705050230026,
-0.26807406544685364,
-0.14265219867229462,
0.32332828640937805,
0.023533383384346962,
-0.09818517416715622,
-0.009772364981472492,
0.09668324142694473,
0.3130805194377899,
-0.11934137344360352,
-0.2229347974061966,
0.023502271622419357,
-0.070673368871212,
-0.17319636046886444,
-0.07914411276578903,
0.19175677001476288,
0.0021249328274279833,
-0.2205791175365448,
0.1207326129078865,
0.16812993586063385,
0.003313723485916853,
0.0003389243211131543,
0.03287145495414734,
0.006824410520493984,
-0.047645434737205505,
0.0023283185437321663,
0.10428234189748764,
-0.0693146139383316,
-0.07010871917009354,
0.29763561487197876,
-0.18315507471561432,
0.01980665512382984,
0.21875083446502686,
-0.1431293785572052,
-0.007264711894094944,
0.39808961749076843,
-0.09788502007722855,
0.1705930083990097,
-0.0427386574447155,
0.05033149570226669,
0.2767932415008545,
0.0612475648522377,
-0.13994768261909485,
0.05450219660997391,
-0.21686159074306488,
0.007376675959676504,
0.05877134948968887,
-0.13929679989814758,
0.27179840207099915,
0.03954342007637024,
0.06211259961128235,
0.03418470919132233,
0.06306920945644379,
-0.02198527380824089,
-0.20443777740001678,
0.013414395973086357,
-0.30485543608665466,
-0.09730265289545059,
-0.018934030085802078,
-0.06696377694606781,
0.0012411940842866898,
-0.16570767760276794,
-0.05673890560865402,
-0.03358794003725052,
0.0916992574930191,
0.10390956699848175,
0.042032502591609955,
-0.0988951176404953,
-0.17099207639694214,
-0.19640018045902252,
-0.18088006973266602,
-0.20913013815879822,
-0.09748244285583496,
-0.21928927302360535,
0.3051932454109192,
0.3899536728858948,
0.05796407535672188,
-0.09245185554027557,
0.2114936113357544,
-0.10866795480251312,
-0.05258175730705261,
0.05042353644967079,
-0.004099553916603327,
-0.2267201691865921,
-0.17775502800941467,
0.008271089754998684,
-0.18028253316879272,
0.07934582978487015,
-0.24585138261318207,
0.09805639833211899,
0.09341426193714142,
0.00017947638116311282,
-0.18028388917446136,
0.20027188956737518,
-0.08846961706876755,
0.14312583208084106,
-0.09668158739805222,
-0.12172029912471771,
-0.3196585774421692,
0.16480737924575806,
-0.3112431764602661,
0.02149357460439205,
-0.11965899914503098,
0.11839056015014648,
0.0544973723590374,
-0.042670078575611115,
-0.11322259902954102,
0.28358620405197144,
0.3282962143421173,
-0.18029743432998657,
-0.1559322476387024,
0.39244502782821655,
-0.06176084280014038,
-0.025222672149538994,
0.17282353341579437,
0.19207005202770233,
-0.43405425548553467,
0.5010279417037964,
0.03787079080939293,
-0.28048720955848694,
0.008418507874011993,
0.0796307921409607,
0.13495966792106628,
-0.36046379804611206,
0.034027472138404846,
0.28230351209640503,
-0.016731085255742073,
0.16412566602230072,
-0.2382044494152069,
0.2512121796607971,
-0.1153116524219513,
0.15097709000110626,
-0.2404031604528427,
0.29521986842155457,
0.02858571894466877,
-0.13476651906967163,
-0.09243866801261902,
0.08194278180599213,
-0.024769917130470276,
0.2396867424249649,
0.04513312876224518,
-0.10178962349891663,
0.04025598615407944,
-0.06105223670601845,
-0.11426617950201035,
-0.07711146771907806,
-0.02007697895169258,
-0.15735958516597748,
-0.35411614179611206,
0.0471501499414444,
-0.4670979082584381,
0.04844103381037712,
0.14601366221904755,
-0.009559539146721363,
0.022562436759471893,
0.21460384130477905,
-0.12421231716871262,
-0.15351544320583344,
-0.3856813609600067,
0.038014233112335205,
-0.14855925738811493,
-0.09785791486501694,
0.040379855781793594,
0.00691991625353694,
0.05316232144832611,
0.131979301571846,
0.024478333070874214,
-0.17218457162380219,
-0.0703440010547638,
0.15831580758094788,
0.24226969480514526,
-0.13220983743667603,
0.05076336860656738,
-0.06305735558271408,
0.29266053438186646,
0.11233000457286835,
0.01035158522427082,
-0.09265800565481186,
0.29565104842185974,
-0.12657642364501953,
-0.03834390640258789,
-0.25072991847991943,
-0.07224112749099731,
0.21436311304569244,
0.06945417821407318,
-0.10954292863607407,
-0.16146481037139893,
-0.1241825595498085,
-0.3192822337150574,
0.007790172006934881,
0.03986567258834839,
-0.0803012102842331,
-0.15915431082248688,
-0.06506235152482986,
0.06419301778078079,
-0.12131614238023758,
0.11812277138233185,
-0.003509514732286334,
0.22651253640651703,
-0.2284611463546753,
-0.20494011044502258,
-0.032133352011442184,
0.1499471366405487,
0.004820512607693672,
0.277580589056015,
-0.1958867907524109,
0.1413787454366684,
0.06554386764764786,
-0.04696525260806084,
-0.20451906323432922,
0.05264855548739433,
-0.12103834003210068,
-0.131834477186203,
0.07023391127586365,
0.04372294247150421,
0.09107242524623871,
-0.037845440208911896,
-0.08884400874376297,
-0.1449766606092453,
-0.5931054949760437,
-0.058837320655584335,
0.23173567652702332,
-0.05928214639425278,
-0.00669786287471652,
-0.04467135667800903,
0.1009281575679779,
0.221931591629982,
0.05923783406615257,
-0.05811651423573494,
-0.028108958154916763,
0.03404932841658592,
-0.2271662801504135,
0.009733452461659908,
-0.007307838182896376,
-0.24023190140724182,
-0.0685834139585495,
0.14296983182430267,
0.09730523079633713,
0.06752194464206696,
0.059167806059122086,
-0.18196530640125275,
-0.12841272354125977,
-0.022878458723425865,
0.10823822766542435,
-0.24841241538524628,
0.06271383166313171,
-0.16313621401786804,
-0.2239210605621338,
-0.03067055344581604,
0.378364235162735,
0.047257356345653534,
0.07487931847572327,
0.2432394176721573,
0.09697336703538895,
0.07347963005304337,
-0.04723144695162773,
0.210473895072937,
-0.1441168636083603,
-0.002287151524797082,
0.02020731195807457,
-0.057531800121068954,
0.00710525456815958,
-0.05204569175839424,
0.1506153792142868,
0.14192020893096924,
0.2454272359609604,
0.17728157341480255,
-0.09978266805410385,
0.0226446483284235,
-0.0873374193906784,
0.045181754976511,
0.17902229726314545,
0.3335875868797302,
0.03908071666955948,
0.3280108571052551,
-0.25599974393844604,
-0.04696038365364075,
-0.032685525715351105,
-0.1840238869190216,
-0.024561060592532158,
0.04804610088467598,
-0.11493045091629028,
0.17273448407649994,
0.22661975026130676,
0.07868941873311996,
0.3300173878669739,
-0.08465734124183655,
0.041472382843494415,
0.02335764281451702,
0.08755907416343689,
0.2556753158569336,
-0.2734729051589966,
0.012584114447236061,
-0.15096935629844666,
0.09558555483818054,
0.16831471025943756,
-0.038858331739902496,
-0.07545964419841766,
-0.2534283995628357,
-0.03826145827770233,
0.016246844083070755,
0.19088010489940643,
0.038556426763534546,
0.018093572929501534,
-0.28102362155914307,
-0.029416080564260483,
-0.22583091259002686,
-0.04639829322695732,
-0.22345727682113647,
-0.03208458051085472,
-0.1758689284324646,
0.037255268543958664,
0.10703154653310776,
0.10006815195083618,
-0.0071101114153862,
-0.05953991413116455,
-0.08628855645656586,
0.015893734991550446,
-0.06340377777814865,
0.09761934727430344,
0.06260275840759277,
0.05182765796780586,
-0.06670969724655151,
0.12687142193317413,
-0.18807920813560486,
0.026878057047724724,
0.26298853754997253,
0.05309167504310608,
0.04399930313229561,
0.23895199596881866,
0.02810624986886978,
0.008550483733415604,
-0.021094486117362976,
0.0016653797356411815,
0.10445789992809296,
-0.13278210163116455,
0.08977889269590378,
0.353573203086853,
-0.031120192259550095,
0.023409517481923103,
0.03494088351726532,
-0.27182358503341675,
0.2992463707923889,
-0.24431300163269043,
0.023175623267889023,
-0.18525223433971405,
0.22459758818149567,
0.10715140402317047,
0.05934949964284897,
0.07126438617706299,
0.16814714670181274,
-0.11953701823949814,
-0.030139334499835968,
0.007368749473243952,
-0.2415297031402588,
0.42096176743507385,
0.15024623274803162,
0.1555016189813614,
0.05054180324077606,
-0.15143750607967377,
0.12376072257757187,
-0.031071718782186508,
-0.10416248440742493,
-0.24785004556179047,
-0.028330154716968536,
-0.041038308292627335,
-0.03199121728539467,
0.0074080051854252815,
0.27195706963539124,
0.28976497054100037,
0.038442693650722504,
-0.06850765645503998,
-0.1365264654159546,
0.022379469126462936,
-0.03578369691967964,
0.028127148747444153,
-0.14301830530166626,
-0.16992972791194916,
-0.21035777032375336,
0.06017792597413063,
0.21994633972644806,
-0.1404244750738144,
0.1516842246055603,
0.23539981245994568,
-0.20177647471427917,
-0.10956355184316635,
-0.04982619732618332,
0.2777884602546692,
-0.08145299553871155,
0.018464019522070885,
-0.03926626965403557,
0.07108661532402039,
-0.09907761961221695,
0.1715836375951767,
0.11616677045822144,
0.11938836425542831,
0.1138518899679184,
-0.14467152953147888,
0.20973777770996094,
0.03977598622441292,
-0.027194978669285774,
0.12840844690799713,
-0.02160593681037426,
0.3981601893901825,
-0.020803339779376984,
0.28140902519226074,
0.10581767559051514,
-0.20395687222480774,
0.036387793719768524,
0.023264940828084946,
0.15677927434444427,
-0.03334636613726616,
0.07606330513954163,
0.18475797772407532,
-0.002574031939730048,
0.1665572226047516,
-0.26730650663375854,
0.050081245601177216,
0.05343776196241379,
-0.2141081690788269,
-0.3192884624004364,
-0.0185871422290802,
-0.06829307228326797,
-0.035954371094703674,
0.07606503367424011,
-0.22745361924171448,
0.10268584638834,
0.09807386994361877,
-0.19569340348243713,
0.06859058886766434,
0.34553173184394836,
-0.08873796463012695,
-0.11936645954847336,
0.14175188541412354,
0.014569989405572414,
0.10888715833425522,
-0.06058565154671669,
0.07453341037034988,
-0.19755446910858154,
-0.1323549449443817,
-0.07389481365680695,
0.3352603316307068,
0.012402601540088654,
0.03916992247104645,
0.06569414585828781,
0.048894353210926056,
0.06288757920265198,
-0.19101150333881378,
0.14344072341918945,
0.009860433638095856,
-0.15492485463619232,
-0.13051298260688782,
0.024427972733974457,
0.12416864931583405,
-0.09264028817415237,
0.24570657312870026,
0.07698903977870941,
-0.015134217217564583,
0.451623797416687,
-0.026379922404885292,
0.001068261219188571,
-0.11254628747701645,
-0.10199559479951859,
0.16390658915042877,
-0.0357077531516552,
0.12978778779506683,
-0.06956115365028381,
0.161970317363739,
0.15983140468597412,
0.03950006514787674,
0.03638707101345062,
0.025559358298778534,
-0.005622140597552061,
0.08322092890739441,
0.19083961844444275,
0.20377391576766968,
-0.10777290165424347,
0.04443901777267456,
-0.3116159439086914,
-0.07664823532104492,
-0.09312816709280014,
0.09008117765188217,
0.22698667645454407,
0.33884677290916443,
-0.11779971420764923,
0.0749073326587677,
-0.2858831584453583,
-0.2027672529220581,
-0.004971475340425968,
-0.06376233696937561,
-0.23890730738639832,
-0.0035476696211844683,
-0.11376890540122986,
0.10600898414850235,
-0.2514723241329193,
0.017475180327892303,
-0.0788329690694809,
-0.10196568071842194,
0.12199300527572632,
0.2431110441684723,
-0.2918916940689087,
0.11130554229021072,
0.16253717243671417,
0.01050786767154932,
0.0018368979217484593,
0.22860462963581085,
0.014435982331633568,
0.18693047761917114,
-0.24213922023773193,
-0.023420266807079315,
0.06643722206354141,
-0.15685304999351501,
0.09692573547363281,
0.02411661297082901,
-0.06638826429843903,
-0.11276339739561081,
0.1531228870153427,
-0.030068697407841682,
-0.037784237414598465,
-0.17459295690059662,
0.09636068344116211,
-0.00645478768274188,
-0.12459559738636017,
-0.026698321104049683,
0.0020303199999034405,
0.003487766720354557,
-0.13851286470890045,
-0.18098673224449158,
0.046857018023729324,
-0.048489902168512344,
-0.005155252758413553,
-0.04349133372306824,
0.13744798302650452,
-0.3177756071090698,
-0.20124973356723785,
-0.17565402388572693,
-0.17738132178783417,
0.14455761015415192,
0.020114481449127197,
-0.1377250850200653,
0.03420957922935486,
-0.1040373221039772,
0.03623269125819206,
-0.1206759512424469,
0.01636204868555069,
-0.22001390159130096,
-0.1757737100124359,
0.15288886427879333,
0.16631460189819336,
-0.0809398964047432,
-0.15231439471244812,
-0.21304568648338318,
0.06142472103238106,
-0.17551155388355255,
-0.13236023485660553,
0.1990698277950287,
-0.11775209754705429,
-0.10820919275283813,
-0.16016227006912231,
0.2182144969701767,
0.14807645976543427,
0.12670162320137024,
0.00032745880889706314,
-0.09119141846895218,
-0.09663590043783188,
0.03356846421957016,
0.02952388860285282,
0.057955361902713776,
-0.23979297280311584,
0.06123460456728935,
0.27200713753700256,
0.18174345791339874,
0.025737786665558815,
0.5151793956756592,
-0.19236542284488678,
0.2030259519815445,
-0.06289616972208023,
0.19081228971481323,
-0.21115483343601227,
0.05131144821643829,
0.15878978371620178,
-0.012816647998988628,
-0.15032507479190826,
-0.22521933913230896,
-0.2233237773180008,
0.15271110832691193,
0.04195519909262657,
-0.08516240119934082,
-0.1879439502954483,
-0.09427676349878311,
0.3351607322692871,
0.27977460622787476,
-0.004067536909133196,
0.13392487168312073,
-0.06245700642466545,
-0.06258939951658249,
0.012122652493417263,
-0.07615002244710922,
-0.03330465033650398,
-0.03493821248412132,
0.09140181541442871,
0.05110159143805504,
0.388012170791626,
0.03236117959022522,
0.06409236788749695,
-0.18138745427131653,
-0.1623799055814743,
-0.006634019315242767,
0.0560651496052742,
0.05007965862751007,
0.20118829607963562,
-0.07023418694734573,
-0.16063779592514038,
0.138094961643219,
0.1277529001235962,
0.16610334813594818,
-0.025907207280397415,
0.15485887229442596,
-0.21675942838191986,
-0.2268943339586258,
-0.11844984441995621,
0.05189582332968712,
-0.05928780511021614,
0.06803977489471436,
-0.26678943634033203,
0.2066895216703415,
-0.09260276705026627,
-0.1535899043083191,
0.31034770607948303,
0.13999544084072113,
-0.23469313979148865,
0.07904662936925888,
-0.018586523830890656,
0.11072748154401779,
0.0067420536652207375,
0.20739823579788208,
0.06921393424272537,
0.032273225486278534,
-0.027385087683796883,
-0.07007534056901932,
0.0846220925450325,
0.06411468982696533,
-0.1669401377439499,
0.02611445263028145,
0.19057977199554443,
0.02874818816781044,
-0.08269037306308746,
0.2291354089975357,
0.12097668647766113,
0.026603814214468002,
0.23127080500125885,
-0.202638640999794,
-0.018983207643032074,
0.04178781434893608,
-0.08236502856016159,
-0.18791413307189941,
-0.038971081376075745,
0.05600469559431076,
-0.008322064764797688,
-0.24708691239356995,
-0.08618808537721634,
0.06170272454619408,
0.04944285750389099,
0.10624920576810837,
-0.09589888900518417,
-0.03890372812747955,
0.034544188529253006,
-0.11556737124919891,
-0.03528068587183952,
0.09350928664207458,
0.10586485266685486,
0.07477869838476181,
0.004393954295665026,
-0.054468147456645966,
-0.022755393758416176,
0.23490010201931,
-0.12206188589334488,
-0.09160485863685608,
0.31890469789505005,
0.06342386454343796,
0.030575942248106003,
-0.1662897914648056,
-0.0979008823633194,
0.05540623888373375,
0.04635660722851753,
0.25397974252700806,
0.20974788069725037,
0.11336886137723923,
0.015337284654378891,
0.013183094561100006,
-0.05618411302566528,
-0.14284977316856384,
0.10199502110481262,
0.12871795892715454,
-0.2535359859466553,
-0.2457047402858734,
-0.24315470457077026,
0.2100946605205536,
0.19077789783477783,
-0.14011265337467194,
0.08818872272968292,
0.18445657193660736,
-0.1122463271021843,
0.16520309448242188,
0.2358740270137787,
-0.287472128868103,
0.19790008664131165,
0.09533732384443283,
0.1081433966755867,
0.039432134479284286,
0.2192005068063736,
-0.10848721861839294,
-0.01732572168111801,
-0.023335272446274757,
-0.03349282220005989,
0.10090005397796631,
0.20083431899547577,
0.3432503044605255,
-0.07240030169487,
0.11812540888786316,
0.09217803925275803,
-0.09078692644834518,
-0.31778278946876526,
-0.14007879793643951,
0.21256814897060394,
-0.07229048758745193,
-0.14905379712581635,
0.10994944721460342,
-0.07017576694488525,
0.09977475553750992,
-0.2118488997220993,
0.04191308841109276,
-0.0475635752081871
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. 1:40 .A boy age six years diagnosed with SLE was treated for two years with steroids and azathioprine, with amelioration of the immunologic abnormalities but worsening of the skin lesions .A male age 25 years had bilateral and symmetric synovitis affecting hands, elbows, and knees, a positive rheumatoid factor (516 IU/mL) and homogeneous ANA (1:640), and low C4 and CH50 (0.07 g/L and 61%) . He fulfilled the American College of Rheumatology (ACR) criteria for rheumatoid arthritis and SLE (rhupus). Although he was diagnosed with prolidase deficiency based on increased imidodipeptiduria, prolidase enzymatic activity was not measured and PEPD sequencing was not performed. This patient did have increased bone turnover, a known cause of imidodipeptiduria in the absence of prolidase deficiency.An Amish boy age 2.5 years with fever of unknown etiology had urinalysis with 2+ | [
-0.33358579874038696,
0.08766995370388031,
0.10790133476257324,
-0.1849967986345291,
0.08727914839982986,
0.24419216811656952,
-0.05636373162269592,
-0.04944789037108421,
0.03474744036793709,
-0.1736871749162674,
0.06197548285126686,
-0.0472399964928627,
0.22178521752357483,
-0.15129925310611725,
-0.24350082874298096,
0.24548585712909698,
0.1064344123005867,
-0.041139665991067886,
-0.05752311274409294,
-0.026549017056822777,
0.09787388145923615,
-0.08138519525527954,
0.20361614227294922,
0.16857720911502838,
0.32243263721466064,
-0.106333889067173,
0.01631481759250164,
0.05380626022815704,
-0.05286706984043121,
0.09517256170511246,
-0.058854516595602036,
-0.20715613663196564,
0.0006805102457292378,
-0.10941414535045624,
0.15992286801338196,
0.050585485994815826,
-0.30886778235435486,
-0.05352207273244858,
0.20644253492355347,
0.11478402465581894,
-0.12345055490732193,
0.12926141917705536,
0.09288962930440903,
0.27015194296836853,
-0.10195154696702957,
-0.008537729270756245,
-0.20141993463039398,
0.1348964422941208,
-0.1740809679031372,
-0.03332751244306564,
0.24146486818790436,
-0.05367464944720268,
-0.19058260321617126,
0.02714802697300911,
0.2474602907896042,
0.01936539076268673,
0.13260889053344727,
0.00007064626697683707,
-0.006814722437411547,
-0.06632637232542038,
0.023861296474933624,
0.0008725590305402875,
-0.08387238532304764,
-0.16011950373649597,
0.189977765083313,
-0.15134263038635254,
0.07782191038131714,
0.1199340969324112,
-0.28379708528518677,
0.0302923321723938,
0.5594494938850403,
-0.05307076498866081,
0.23492830991744995,
0.016697829589247704,
0.07008229941129684,
0.11707250028848648,
0.04341069981455803,
-0.09813716262578964,
-0.1726178377866745,
-0.1375368982553482,
-0.10509167611598969,
0.2814875841140747,
-0.06963030993938446,
0.17991816997528076,
-0.014594652689993382,
0.21177171170711517,
-0.05624909698963165,
0.16693568229675293,
0.14574500918388367,
-0.1382826268672943,
0.17460334300994873,
-0.3017142117023468,
-0.04073029384016991,
-0.20802448689937592,
-0.07194172590970993,
0.09612183272838593,
-0.1339220404624939,
-0.028167875483632088,
-0.10919050127267838,
0.13507544994354248,
0.13744515180587769,
0.005764036439359188,
-0.12713555991649628,
-0.009687387384474277,
-0.02186376415193081,
-0.07455319911241531,
-0.027328234165906906,
-0.01754780113697052,
-0.1555250883102417,
0.0341222882270813,
0.3287096619606018,
0.07884692400693893,
-0.11904723942279816,
0.09107290953397751,
-0.1103498712182045,
-0.10335595160722733,
0.06527602672576904,
-0.014316985383629799,
-0.2962264120578766,
-0.2868829071521759,
-0.06892992556095123,
0.04224470630288124,
0.13692422211170197,
-0.3083077371120453,
0.07656311243772507,
0.12902523577213287,
0.03685661032795906,
0.18141578137874603,
0.23471549153327942,
-0.16895538568496704,
0.13949736952781677,
-0.1759265959262848,
-0.08944202959537506,
-0.2885962128639221,
-0.003847331739962101,
-0.0717511996626854,
-0.03414718806743622,
-0.11371199041604996,
-0.015645580366253853,
0.11469199508428574,
-0.0012087743962183595,
-0.01891408860683441,
0.3265366852283478,
0.2837866246700287,
-0.052105046808719635,
0.07574225962162018,
0.3692789673805237,
-0.08894797414541245,
0.10708480328321457,
0.10505791008472443,
0.17071424424648285,
-0.1380109041929245,
0.28662869334220886,
0.027049291878938675,
0.036584991961717606,
0.007637799717485905,
-0.10896539688110352,
0.10185720026493073,
-0.14922983944416046,
0.2168298363685608,
0.14927861094474792,
-0.19741122424602509,
0.2573094069957733,
-0.2363119274377823,
0.19923675060272217,
-0.12410379201173782,
0.07441696524620056,
-0.16661588847637177,
0.23546551167964935,
0.012317012995481491,
-0.05864935368299484,
0.027988992631435394,
0.14103764295578003,
0.029962759464979172,
0.31870296597480774,
-0.06819020956754684,
0.02688468061387539,
0.18744897842407227,
-0.06929807364940643,
0.005089718848466873,
-0.2117704451084137,
-0.06619443744421005,
-0.0974779725074768,
-0.25169751048088074,
0.01595836691558361,
-0.32252341508865356,
0.10142777115106583,
0.09259606152772903,
0.06839782744646072,
0.05652476102113724,
0.3327423930168152,
-0.0005353569285944104,
-0.17269961535930634,
-0.27278125286102295,
0.21424968540668488,
-0.3139290511608124,
0.05520595237612724,
-0.031167054548859596,
0.031414780765771866,
0.01857588067650795,
0.18654848635196686,
-0.16645418107509613,
0.07032782584428787,
0.07267986238002777,
0.0990324541926384,
0.2036355435848236,
0.010581821203231812,
0.02738748863339424,
-0.04095792397856712,
0.42467743158340454,
0.058898720890283585,
0.12117605656385422,
-0.11378445476293564,
0.2013464719057083,
-0.04950685426592827,
-0.08801665902137756,
-0.407204270362854,
-0.10657161474227905,
-0.14981235563755035,
0.08381839096546173,
-0.2389243096113205,
-0.20392538607120514,
-0.17305989563465118,
-0.14325201511383057,
0.030675068497657776,
0.033758871257305145,
-0.11010409891605377,
-0.049170251935720444,
-0.11540073901414871,
0.09552161395549774,
-0.1853145807981491,
0.06412167102098465,
0.2917625308036804,
0.20550961792469025,
-0.1511041671037674,
-0.4174966812133789,
-0.06100351735949516,
0.15220430493354797,
0.030805889517068863,
0.11338642239570618,
-0.12138716876506805,
-0.04811897128820419,
0.038512371480464935,
0.023600418120622635,
-0.10056444257497787,
0.14722229540348053,
-0.33270224928855896,
-0.007601508870720863,
0.05155450478196144,
-0.02202931046485901,
0.0578656941652298,
-0.17250514030456543,
0.12438607960939407,
-0.04549391567707062,
-0.4483327865600586,
0.009951718151569366,
0.24218998849391937,
-0.11904478818178177,
0.02875610999763012,
0.12197906523942947,
0.08291610330343246,
0.18201081454753876,
0.1266031712293625,
0.12856875360012054,
-0.052814580500125885,
0.004543246701359749,
-0.18435963988304138,
0.2629103660583496,
-0.03013613075017929,
-0.29176682233810425,
0.04317055270075798,
0.009177394211292267,
0.09871802479028702,
-0.04908779636025429,
0.14370587468147278,
-0.19390951097011566,
-0.2622568905353546,
-0.09639203548431396,
0.010216413997113705,
-0.18201327323913574,
0.014367691241204739,
0.024115202948451042,
-0.18506993353366852,
-0.017323803156614304,
0.25775739550590515,
0.009407038800418377,
-0.05399442836642265,
0.2758282721042633,
-0.011973975226283073,
0.12535931169986725,
0.05649682134389877,
0.1898186206817627,
-0.1412373185157776,
-0.06620147079229355,
0.04774732142686844,
-0.006428885273635387,
0.015867728739976883,
-0.02789607271552086,
0.04065331816673279,
0.10928470641374588,
0.22972670197486877,
0.10088089853525162,
-0.025986967608332634,
-0.026042990386486053,
-0.006763610988855362,
-0.012645632028579712,
0.22008326649665833,
0.15639561414718628,
-0.17009860277175903,
0.2709427773952484,
-0.1475275307893753,
0.06563286483287811,
-0.023112446069717407,
-0.16675899922847748,
0.005017008166760206,
-0.0048947324976325035,
-0.23423823714256287,
0.2139272689819336,
0.06273198127746582,
0.0006164211081340909,
0.4169616401195526,
-0.1744973361492157,
0.0829043760895729,
0.02241845242679119,
0.16143471002578735,
0.3336184322834015,
-0.12101008743047714,
-0.012148510664701462,
-0.11758433282375336,
-0.0328848659992218,
0.11016999185085297,
0.013296984136104584,
-0.19481226801872253,
-0.21186739206314087,
-0.024479862302541733,
0.061493393033742905,
0.1679578721523285,
0.02405533939599991,
-0.0013452117564156651,
-0.14294998347759247,
-0.05793192610144615,
-0.2834124267101288,
-0.04142140969634056,
-0.32720130681991577,
0.07428988069295883,
-0.12178294360637665,
-0.05359289050102234,
0.17867198586463928,
0.14944228529930115,
-0.15741674602031708,
-0.04002545773983002,
-0.0010828332742676139,
-0.04219472408294678,
-0.20093593001365662,
0.11077848076820374,
0.10532175004482269,
-0.20497532188892365,
-0.15437541902065277,
0.10929162800312042,
-0.19687677919864655,
0.07745601236820221,
0.26968252658843994,
0.1938251554965973,
-0.005980255082249641,
0.24369187653064728,
0.19290195405483246,
-0.08777326345443726,
-0.11560411751270294,
0.040736764669418335,
0.014272456988692284,
-0.11309350281953812,
-0.1506846696138382,
0.23691900074481964,
0.05716395005583763,
0.057964880019426346,
-0.002087005414068699,
-0.291064590215683,
0.21471285820007324,
-0.028741223737597466,
-0.0557812862098217,
-0.23163267970085144,
0.08966848254203796,
0.1480194479227066,
0.19358821213245392,
0.09171655774116516,
0.12086710333824158,
-0.08342947065830231,
0.06936579942703247,
0.07979146391153336,
-0.14964674413204193,
0.33565080165863037,
0.10472691804170609,
0.03970298171043396,
0.07275813072919846,
-0.405125230550766,
0.023836692795157433,
0.09708202630281448,
-0.004169494844973087,
-0.3003878891468048,
0.19099655747413635,
0.14408183097839355,
0.05910264700651169,
0.026318060234189034,
0.2866314649581909,
0.38641875982284546,
0.033225130289793015,
-0.13742251694202423,
0.019603561609983444,
0.05039301514625549,
0.05541180074214935,
0.012776377610862255,
-0.19836845993995667,
-0.05789244920015335,
-0.30138665437698364,
0.1596873551607132,
0.16197696328163147,
0.015954378992319107,
0.23264580965042114,
0.07747594267129898,
-0.046621158719062805,
-0.11165717989206314,
-0.09899839013814926,
0.2208303064107895,
-0.041804008185863495,
-0.1063937395811081,
-0.19358395040035248,
0.023879798129200935,
-0.09517473727464676,
0.13426156342029572,
0.12783880531787872,
0.10663978010416031,
0.11413648724555969,
-0.19270876049995422,
0.1471656709909439,
0.029013589024543762,
0.04340749979019165,
-0.07703094184398651,
0.07157866656780243,
0.2544693648815155,
-0.03206924349069595,
0.48689988255500793,
-0.09104791283607483,
-0.11948981881141663,
-0.08680187165737152,
-0.01715497300028801,
0.0672503188252449,
-0.1431984156370163,
0.1389210969209671,
0.2522881031036377,
-0.018309520557522774,
0.18200933933258057,
-0.26269659399986267,
0.082227922976017,
0.10415510833263397,
-0.2954033315181732,
-0.13846445083618164,
-0.2083742320537567,
-0.19902823865413666,
-0.08271372318267822,
0.0012632810976356268,
-0.11450103670358658,
0.07936166971921921,
0.04035335034132004,
-0.14401230216026306,
0.0491788424551487,
0.2890394926071167,
-0.18293190002441406,
-0.06424243748188019,
0.18026527762413025,
-0.03573821485042572,
0.038443125784397125,
0.09463708847761154,
0.016247762367129326,
-0.13405247032642365,
-0.09611272811889648,
0.010964120738208294,
0.28060150146484375,
0.0466836616396904,
0.006079653277993202,
0.2733003497123718,
-0.08726589381694794,
0.14877848327159882,
-0.2442803531885147,
0.144766703248024,
0.08911507576704025,
-0.17559486627578735,
0.033508628606796265,
-0.000710827880539,
0.09187726676464081,
-0.04659946262836456,
0.2984562814235687,
0.10545200854539871,
-0.09746376425027847,
0.5038546323776245,
0.05570857599377632,
0.09999788552522659,
0.004672656301409006,
0.05108653008937836,
0.09780248254537582,
-0.10534115135669708,
0.04308299347758293,
-0.2187887281179428,
0.12752926349639893,
0.3464233875274658,
0.1267179399728775,
-0.16116204857826233,
0.15359391272068024,
0.0006637817714363337,
0.06625272333621979,
0.33813899755477905,
0.36147427558898926,
-0.028443634510040283,
-0.2127399891614914,
-0.2550187408924103,
-0.2246355265378952,
-0.023392533883452415,
0.20301730930805206,
0.13321152329444885,
0.23715603351593018,
-0.06772872805595398,
-0.013371977023780346,
-0.19475309550762177,
-0.1325865238904953,
0.18993079662322998,
-0.11292712390422821,
-0.28605106472969055,
0.13342419266700745,
-0.06565948575735092,
-0.0402899831533432,
-0.3480668067932129,
-0.11961393803358078,
-0.14152933657169342,
0.04336930066347122,
0.04590315744280815,
0.09686426818370819,
-0.10134156048297882,
-0.019310396164655685,
0.0005111509235575795,
0.08572648465633392,
0.11900769174098969,
0.21659259498119354,
0.05832265689969063,
0.16750919818878174,
-0.029668694362044334,
-0.013672685250639915,
0.061668455600738525,
-0.030401036143302917,
-0.04392435774207115,
0.008514265529811382,
0.10323213785886765,
-0.006074300967156887,
0.12630879878997803,
-0.00626372592523694,
-0.03306180238723755,
-0.10429446399211884,
-0.07454783469438553,
0.03466315194964409,
-0.10227178037166595,
-0.15185824036598206,
-0.01357478927820921,
0.11614352464675903,
-0.023076746612787247,
-0.0951000228524208,
-0.1021675318479538,
-0.13696467876434326,
0.23181308805942535,
-0.0011435411870479584,
0.16647091507911682,
-0.20729386806488037,
-0.25109216570854187,
-0.038990411907434464,
-0.11957798153162003,
0.11926191300153732,
-0.16077710688114166,
-0.17423416674137115,
0.06774173676967621,
-0.20449614524841309,
0.02992379665374756,
-0.18189209699630737,
0.22952105104923248,
-0.012376535683870316,
0.06187077984213829,
0.19089698791503906,
0.13950224220752716,
-0.049719057977199554,
0.07627980411052704,
-0.13224907219409943,
0.1359608918428421,
-0.0025870029348880053,
0.052426766604185104,
0.24412260949611664,
-0.22542695701122284,
-0.08063735067844391,
-0.35266727209091187,
0.06705654412508011,
0.11920762062072754,
-0.014933743514120579,
-0.18610812723636627,
-0.047481928020715714,
-0.0057891360484063625,
0.061622731387615204,
0.027719343081116676,
-0.26882123947143555,
-0.3429551124572754,
-0.08691613376140594,
0.1288316696882248,
0.22987689077854156,
-0.10402761399745941,
0.257300466299057,
-0.04336262866854668,
0.2460506558418274,
0.04482969269156456,
0.014439118094742298,
-0.1374090313911438,
0.10423275828361511,
-0.01264082733541727,
-0.07541251182556152,
-0.31580787897109985,
-0.16241559386253357,
-0.17142516374588013,
0.24796435236930847,
0.07040690630674362,
-0.04774417728185654,
-0.19464637339115143,
-0.1856778860092163,
0.19587045907974243,
0.2681964039802551,
-0.033148497343063354,
0.1782718002796173,
-0.00941488891839981,
-0.0454060360789299,
-0.09168849140405655,
-0.0970020517706871,
-0.04901048168540001,
-0.18052570521831512,
0.002954684430733323,
0.019448677077889442,
0.3182651400566101,
0.032706424593925476,
-0.16380248963832855,
-0.07354714721441269,
0.02469792403280735,
-0.06322208046913147,
0.15274344384670258,
0.15313993394374847,
0.22543159127235413,
-0.08198468387126923,
-0.09371212124824524,
0.006346391513943672,
0.0696481391787529,
0.03915643319487572,
-0.014971901662647724,
0.1342945247888565,
-0.034054726362228394,
-0.09027855843305588,
-0.1669802963733673,
0.1491147130727768,
-0.054713860154151917,
-0.03834327682852745,
-0.2791447043418884,
0.17893314361572266,
-0.043720632791519165,
-0.15918461978435516,
0.23119740188121796,
0.08144393563270569,
-0.11339212208986282,
0.16286413371562958,
-0.10724132508039474,
-0.15878669917583466,
-0.21828027069568634,
0.2785567045211792,
0.269313246011734,
0.13235345482826233,
-0.011192183010280132,
0.07901424914598465,
-0.07666926085948944,
0.0008815493783913553,
-0.22939465939998627,
0.003055904060602188,
0.3721654713153839,
-0.008306903764605522,
-0.026733892038464546,
0.13975195586681366,
-0.12135022133588791,
0.029751773923635483,
0.16727475821971893,
-0.04803803190588951,
-0.049271728843450546,
0.11023745685815811,
-0.07580114156007767,
-0.20099936425685883,
0.017282379791140556,
0.07235962897539139,
-0.027724631130695343,
-0.11225147545337677,
-0.19753754138946533,
0.1798492819070816,
0.15303733944892883,
0.03309869021177292,
-0.2713879346847534,
0.13752485811710358,
0.00428540725260973,
-0.19356097280979156,
0.022823987528681755,
-0.03317052870988846,
0.1246517151594162,
-0.013793674297630787,
-0.032540213316679,
-0.2387288361787796,
-0.1189662367105484,
0.1453048586845398,
0.04591241106390953,
0.025958484038710594,
0.3315366506576538,
0.0599215105175972,
0.13646548986434937,
-0.1799381971359253,
-0.3239911198616028,
0.0337732769548893,
0.17640766501426697,
0.08491470664739609,
0.014157514087855816,
0.12233524024486542,
-0.016279347240924835,
-0.10940621048212051,
0.04458942264318466,
-0.032210782170295715,
-0.007483578287065029,
0.23686879873275757,
-0.12062638252973557,
-0.3294830322265625,
-0.1816422939300537,
0.11990158259868622,
0.21443982422351837,
-0.13045190274715424,
0.04134965315461159,
0.15274134278297424,
-0.18725121021270752,
0.13478344678878784,
0.14699499309062958,
-0.31442397832870483,
0.22398574650287628,
0.19546006619930267,
0.22132299840450287,
0.11355826258659363,
0.028866883367300034,
-0.09251491725444794,
-0.038190994411706924,
-0.035770244896411896,
-0.1599307656288147,
-0.05639998987317085,
0.24487560987472534,
0.3359871804714203,
-0.03981076925992966,
-0.022212445735931396,
-0.009402808733284473,
-0.2173139750957489,
-0.3371545970439911,
0.03828887641429901,
0.14668235182762146,
-0.11177589744329453,
-0.21441511809825897,
0.010397333651781082,
-0.11424539983272552,
0.06468688696622849,
-0.05128799006342888,
-0.08621684461832047,
0.06525586545467377
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. the American College of Rheumatology (ACR) criteria for rheumatoid arthritis and SLE (rhupus). Although he was diagnosed with prolidase deficiency based on increased imidodipeptiduria, prolidase enzymatic activity was not measured and PEPD sequencing was not performed. This patient did have increased bone turnover, a known cause of imidodipeptiduria in the absence of prolidase deficiency.An Amish boy age 2.5 years with fever of unknown etiology had urinalysis with 2+ proteinuria and hypoalbuminemia, ANA of 1:1080 with speckled pattern, and a positive anti-dsDNA .Of two sibs reported by Klar et al :A girl age eight years had Raynaud's phenomenon, a positive ANA (1:1280; homogenous pattern), a positive anti ds-DNA >1:160, positive anti-ENA, anti-RNP and anti-Smith;Her brother, age | [
-0.14807379245758057,
0.08876051753759384,
-0.010470773093402386,
-0.04428413137793541,
0.07576026767492294,
0.27527916431427,
-0.21403634548187256,
-0.03824848681688309,
-0.05307986959815025,
-0.2252524197101593,
0.07339981943368912,
-0.12381360679864883,
0.28976285457611084,
-0.11199599504470825,
-0.23927755653858185,
0.25604763627052307,
0.0387054979801178,
-0.04285392165184021,
0.021156029775738716,
-0.009393860585987568,
-0.003353605279698968,
-0.25231027603149414,
0.34143558144569397,
0.2843688726425171,
0.1338467299938202,
0.020779965445399284,
-0.16900861263275146,
0.13428112864494324,
0.06117631494998932,
0.06415470689535141,
-0.02259894832968712,
-0.1207607313990593,
0.014824454672634602,
0.09560791403055191,
0.0028244631830602884,
-0.0618135929107666,
-0.28552010655403137,
-0.005305469501763582,
0.2973189651966095,
0.11335331201553345,
0.021942809224128723,
-0.032706424593925476,
0.17159226536750793,
0.2759954333305359,
-0.07447928190231323,
-0.17719048261642456,
0.007175023667514324,
-0.049685049802064896,
-0.15954190492630005,
-0.08417718857526779,
0.23864449560642242,
0.007472168188542128,
-0.1443926990032196,
0.14298246800899506,
0.19478709995746613,
0.09213263541460037,
0.15624135732650757,
0.14502383768558502,
-0.08895920217037201,
-0.0772458016872406,
-0.03402571380138397,
0.1401783525943756,
-0.1767483800649643,
-0.2000802904367447,
0.34195438027381897,
-0.2032831907272339,
0.12820209562778473,
0.2808856964111328,
-0.2548438310623169,
0.06238928437232971,
0.34608718752861023,
-0.2067948281764984,
0.18924793601036072,
-0.08023764193058014,
-0.02280208095908165,
0.2656978368759155,
0.10561675578355789,
-0.10123088955879211,
0.02006584405899048,
-0.2169235646724701,
-0.06476592272520065,
0.07319362461566925,
-0.03910362720489502,
0.254734069108963,
-0.013783099129796028,
0.02875378541648388,
-0.028164349496364594,
0.1785394847393036,
0.1605902761220932,
-0.10408990830183029,
0.07342375069856644,
-0.20875370502471924,
-0.09373444318771362,
-0.06843883544206619,
-0.018325893208384514,
0.014773091301321983,
-0.14536242187023163,
-0.07785438001155853,
0.00846773013472557,
0.06354615837335587,
0.013493433594703674,
0.055632930248975754,
-0.12293843924999237,
-0.18681120872497559,
-0.10492975264787674,
-0.15984173119068146,
-0.11830037087202072,
-0.10884997993707657,
-0.1552688628435135,
0.1001148372888565,
0.276723712682724,
0.061453841626644135,
-0.12054537236690521,
0.09139249473810196,
-0.03404717519879341,
-0.15854519605636597,
0.034852880984544754,
0.03358294442296028,
-0.2395823746919632,
-0.1432362198829651,
0.18711765110492706,
-0.19374322891235352,
0.10879722982645035,
-0.17789798974990845,
-0.009300419129431248,
0.01598883792757988,
-0.0121482377871871,
-0.018989456817507744,
0.10034143924713135,
-0.10004919022321701,
0.025970788672566414,
-0.06708860397338867,
-0.02878299169242382,
-0.42114272713661194,
0.06609786301851273,
-0.26176750659942627,
0.1149754598736763,
-0.10695355385541916,
-0.02100195363163948,
0.18331706523895264,
0.047145918011665344,
-0.08414031565189362,
0.23983903229236603,
0.28648465871810913,
-0.07442028820514679,
-0.19318802654743195,
0.36570295691490173,
-0.09169629961252213,
-0.02922891080379486,
0.060801975429058075,
0.2185146063566208,
-0.2684642970561981,
0.46003586053848267,
0.010396028868854046,
-0.05609964579343796,
0.02369435504078865,
0.006359156686812639,
0.2059471160173416,
-0.26757583022117615,
0.025607628747820854,
0.17490708827972412,
0.009497224353253841,
0.07758620381355286,
-0.2595457136631012,
0.29233765602111816,
-0.02816830389201641,
0.11740037053823471,
-0.27459055185317993,
0.11081000417470932,
0.12422344088554382,
-0.17683617770671844,
-0.061446938663721085,
0.06792726367712021,
0.009248864836990833,
0.27733245491981506,
-0.04789868742227554,
-0.1179322823882103,
0.10625016689300537,
-0.1898207664489746,
-0.09085052460432053,
-0.06490470468997955,
-0.04764162376523018,
0.052806954830884933,
-0.3096742033958435,
-0.17148330807685852,
-0.3446836471557617,
-0.020301805809140205,
0.0794496089220047,
-0.00651724636554718,
-0.0019457966554909945,
0.26456218957901,
0.08758744597434998,
-0.18267086148262024,
-0.2814502716064453,
0.056564513593912125,
-0.18967434763908386,
0.01811065711081028,
0.0038584826979786158,
-0.009051213972270489,
-0.01150420866906643,
0.12048187851905823,
-0.020883912220597267,
-0.05348104238510132,
0.03917109593749046,
0.08715366572141647,
0.2670135796070099,
-0.18719767034053802,
-0.007120856083929539,
-0.057979509234428406,
0.346668541431427,
0.20429696142673492,
0.09928489476442337,
-0.04900449141860008,
0.17728596925735474,
0.024973833933472633,
0.03893083706498146,
-0.2642301321029663,
0.0447964146733284,
0.040401097387075424,
0.17792128026485443,
-0.1779489368200302,
-0.17344436049461365,
-0.14191660284996033,
-0.2490178793668747,
0.03028072789311409,
0.08689026534557343,
-0.02884051576256752,
-0.010636724531650543,
0.0675785019993782,
0.06552039831876755,
-0.17460785806179047,
0.13530568778514862,
0.1704109013080597,
0.10466009378433228,
-0.21167001128196716,
-0.13558954000473022,
-0.09771271795034409,
0.08543013036251068,
0.1465463638305664,
0.14663803577423096,
-0.13784678280353546,
0.07282455265522003,
0.07459230720996857,
-0.10328050702810287,
-0.19842256605625153,
0.07095075398683548,
-0.09132800251245499,
-0.09699414670467377,
-0.029992645606398582,
0.08897092193365097,
0.05032087862491608,
-0.10996948927640915,
-0.01258876547217369,
-0.020038314163684845,
-0.42167750000953674,
-0.06257777661085129,
0.2673923671245575,
-0.07169729471206665,
-0.01684844307601452,
0.002590944990515709,
0.04790481925010681,
0.205173060297966,
0.012120828032493591,
-0.033044930547475815,
-0.08845213055610657,
0.059208378195762634,
-0.2533305287361145,
0.009454355575144291,
0.06345431506633759,
-0.16930635273456573,
0.014568815007805824,
0.16728658974170685,
0.20411105453968048,
0.1308935284614563,
-0.022179557010531425,
-0.037081047892570496,
-0.17689216136932373,
-0.0004936474724672735,
0.07971306145191193,
-0.3098439872264862,
0.04240996018052101,
-0.042110834270715714,
-0.14210829138755798,
-0.12832659482955933,
0.22366830706596375,
0.13047003746032715,
0.002205176744610071,
0.23855726420879364,
0.04090947285294533,
-0.1280638575553894,
0.057294201105833054,
0.1768839806318283,
-0.19973741471767426,
-0.045603200793266296,
0.03450813144445419,
-0.11758504807949066,
0.03679218143224716,
-0.1310407966375351,
0.17090244591236115,
0.16787761449813843,
0.2528417110443115,
0.16758094727993011,
-0.05658114328980446,
-0.006876845844089985,
0.06325904279947281,
0.03272391855716705,
0.22030991315841675,
0.2758030295372009,
-0.07201706618070602,
0.22896099090576172,
-0.11484197527170181,
-0.03209533914923668,
-0.06496427953243256,
-0.17495568096637726,
-0.006648620590567589,
-0.017738187685608864,
-0.07173992693424225,
0.07260293513536453,
0.10156375914812088,
0.07675743848085403,
0.23521307110786438,
-0.06158865615725517,
0.08551163226366043,
0.03972665220499039,
0.019007151946425438,
0.1903964877128601,
-0.22107231616973877,
0.01301343459635973,
-0.1336555778980255,
0.20147566497325897,
0.1610954850912094,
0.1057884693145752,
-0.20548461377620697,
-0.1768959015607834,
-0.06799143552780151,
0.008194820024073124,
0.08699687570333481,
0.02562088891863823,
-0.03173410892486572,
-0.2336428016424179,
-0.025503860786557198,
-0.1856803148984909,
0.03127904236316681,
-0.12892292439937592,
0.1295623630285263,
-0.15027552843093872,
0.005041162483394146,
0.07901795208454132,
0.04662744700908661,
-0.09765879064798355,
-0.20780104398727417,
-0.0701523944735527,
-0.022885087877511978,
-0.054511260241270065,
0.13552559912204742,
0.00875910185277462,
-0.05255395919084549,
0.004364393651485443,
0.031497761607170105,
-0.12691177427768707,
0.02236548624932766,
0.2366628497838974,
0.014596283435821533,
0.011151212267577648,
0.20655854046344757,
0.18082809448242188,
0.11012391000986099,
0.03663206472992897,
0.020595910027623177,
0.026330675929784775,
-0.06771810352802277,
0.13226008415222168,
0.31695157289505005,
0.0002255811996292323,
0.018735725432634354,
0.08697158843278885,
-0.28093019127845764,
0.21417824923992157,
-0.12743420898914337,
0.00395224429666996,
-0.09856048226356506,
0.16149181127548218,
0.10003937035799026,
-0.015494066290557384,
0.1049000695347786,
0.2339634746313095,
-0.10420047491788864,
0.009451989084482193,
-0.0757247731089592,
-0.19165106117725372,
0.26688483357429504,
0.14183175563812256,
0.10895717889070511,
0.11903143674135208,
-0.3025832772254944,
0.08278047293424606,
-0.03343355655670166,
-0.07617824524641037,
-0.4284103214740753,
-0.10799485445022583,
0.0507080964744091,
-0.20273758471012115,
0.0383080393075943,
0.16251090168952942,
0.16009627282619476,
0.04261697456240654,
-0.1406043916940689,
-0.043668195605278015,
0.05167646333575249,
0.034920234233140945,
-0.004292686004191637,
-0.019972696900367737,
-0.18031993508338928,
-0.15897274017333984,
0.08300980180501938,
0.07725029438734055,
-0.06424084305763245,
0.07812115550041199,
0.1390105038881302,
-0.05276988819241524,
0.0037733386270701885,
0.11543126404285431,
0.09047728776931763,
-0.07555104047060013,
-0.055553141981363297,
-0.04538210853934288,
0.12450756877660751,
-0.1269860714673996,
0.2720651924610138,
0.2303401380777359,
0.20507146418094635,
0.18092991411685944,
-0.1514972597360611,
0.19159352779388428,
0.019968783482909203,
0.007276229094713926,
0.11637692898511887,
0.03020205907523632,
0.337441623210907,
0.12272675335407257,
0.28369778394699097,
0.13880124688148499,
-0.18811798095703125,
-0.06101688742637634,
-0.05198798328638077,
0.10153765976428986,
-0.09331803768873215,
0.014016927219927311,
0.1779376119375229,
0.04658300429582596,
0.05921415239572525,
-0.05051371827721596,
0.06964462995529175,
0.047288909554481506,
-0.2589426040649414,
-0.2417738139629364,
0.0033853519707918167,
-0.1275702863931656,
-0.14277243614196777,
0.09036222845315933,
-0.07606229186058044,
0.21240070462226868,
0.1559925675392151,
-0.09236432611942291,
0.0755745992064476,
0.2884531617164612,
-0.038877516984939575,
-0.05669039860367775,
0.06932055950164795,
0.0012374378275126219,
0.1117873415350914,
0.02115364372730255,
0.07685518264770508,
-0.26787060499191284,
-0.07099471986293793,
-0.01656395010650158,
0.339295893907547,
0.17902633547782898,
0.12276531755924225,
0.1326945722103119,
0.15297049283981323,
0.1489308476448059,
-0.22402791678905487,
0.212797150015831,
-0.0022961157374083996,
-0.1343393325805664,
-0.0771208256483078,
0.055745117366313934,
0.06175311282277107,
-0.14121048152446747,
0.18770769238471985,
0.10550838708877563,
-0.14740805327892303,
0.4651622176170349,
-0.08808238804340363,
-0.12404040992259979,
-0.027175642549991608,
-0.05079834535717964,
0.030438527464866638,
-0.12638135254383087,
0.2931854724884033,
-0.1054299920797348,
0.20860923826694489,
0.18836545944213867,
-0.007687854114919901,
-0.16378402709960938,
0.11493992805480957,
0.05714971572160721,
0.11456184834241867,
0.11977188289165497,
0.14077535271644592,
-0.1357862949371338,
-0.05459703132510185,
-0.30379945039749146,
-0.10964317619800568,
-0.15481634438037872,
0.15796683728694916,
0.21338669955730438,
0.22922146320343018,
-0.0667361244559288,
0.08442336320877075,
-0.32372212409973145,
-0.16224049031734467,
0.02859702706336975,
0.001824149745516479,
-0.25423911213874817,
0.013705496676266193,
-0.2274467945098877,
0.054903801530599594,
-0.31708839535713196,
-0.02552765980362892,
-0.05509454756975174,
0.008029070682823658,
0.08030205965042114,
0.09452696889638901,
-0.2724548578262329,
0.07592178136110306,
0.05429786071181297,
0.10010655969381332,
0.006193185690790415,
0.22368283569812775,
-0.07753974199295044,
0.251181960105896,
-0.16198882460594177,
0.09991522878408432,
-0.10977023094892502,
0.05719199404120445,
0.11494852602481842,
0.03614391013979912,
-0.10611169040203094,
0.05215006321668625,
0.18663373589515686,
-0.057051096111536026,
-0.020648596808314323,
-0.2895944118499756,
0.007867895066738129,
-0.07130439579486847,
-0.09051983058452606,
-0.08917658030986786,
0.033848874270915985,
0.13571810722351074,
-0.16183307766914368,
-0.10324235260486603,
-0.012264403514564037,
-0.1966814398765564,
0.015503560192883015,
0.04960111156105995,
0.0386989451944828,
-0.22605513036251068,
-0.12128385156393051,
-0.15420596301555634,
-0.12719039618968964,
0.08419433981180191,
-0.0017203324241563678,
-0.12283654510974884,
-0.029832009226083755,
-0.08521132171154022,
0.1457473188638687,
-0.11785050481557846,
0.11509986221790314,
-0.21917228400707245,
-0.1354490965604782,
0.09736477583646774,
0.16571524739265442,
0.004824868403375149,
-0.1937166452407837,
-0.20205020904541016,
0.07320304214954376,
0.008410075679421425,
-0.007203859742730856,
0.13293525576591492,
-0.09139351546764374,
-0.04399515315890312,
-0.18190865218639374,
0.1881282478570938,
0.18696539103984833,
0.09436371922492981,
-0.0416518896818161,
-0.10311774909496307,
-0.0715612918138504,
0.009223594330251217,
-0.14450150728225708,
-0.10684231668710709,
-0.357221394777298,
-0.09130106121301651,
0.06209827587008476,
0.09334947168827057,
-0.12927396595478058,
0.42799434065818787,
-0.21065755188465118,
0.22737425565719604,
-0.017267199233174324,
0.11235891282558441,
-0.18159730732440948,
0.014407473616302013,
-0.030364347621798515,
-0.17239610850811005,
-0.2660296857357025,
-0.14656412601470947,
-0.09020373225212097,
0.20357155799865723,
0.02564985118806362,
-0.14810624718666077,
-0.0963086485862732,
-0.09718240052461624,
0.24327796697616577,
0.23388732969760895,
-0.025457628071308136,
0.16504579782485962,
0.01189983356744051,
-0.04909514635801315,
-0.0027844691649079323,
-0.23002935945987701,
-0.08129343390464783,
-0.15815268456935883,
0.06986037641763687,
0.12084051221609116,
0.2481887936592102,
0.0028854496777057648,
0.010081019252538681,
-0.007579481694847345,
-0.05692332237958908,
0.1365930289030075,
0.10856321454048157,
0.028555024415254593,
0.228944331407547,
-0.14282673597335815,
-0.2571229636669159,
0.16737811267375946,
0.08751053363084793,
0.05381092429161072,
0.04800640046596527,
0.27774110436439514,
-0.07952189445495605,
-0.2488057166337967,
-0.16265802085399628,
0.028989437967538834,
0.056300435215234756,
0.08110442757606506,
-0.4564198851585388,
0.13874901831150055,
-0.12255421280860901,
-0.16755227744579315,
0.2238798439502716,
0.09242390096187592,
-0.2502443194389343,
0.07747752219438553,
0.007390188984572887,
0.015762174502015114,
-0.05210364609956741,
0.18765167891979218,
0.04556219279766083,
0.08544640988111496,
0.04713161662220955,
-0.08240693062543869,
0.057550396770238876,
0.0700148195028305,
-0.19192104041576385,
0.030490318313241005,
0.22241690754890442,
-0.05087731406092644,
-0.08942243456840515,
0.17535239458084106,
0.07800757139921188,
0.0486903041601181,
0.16945569217205048,
-0.12822145223617554,
-0.06839872151613235,
0.19315028190612793,
-0.20415432751178741,
-0.17195464670658112,
-0.07255053520202637,
0.09350521862506866,
-0.2724005877971649,
-0.17159663140773773,
-0.028952378779649734,
0.22616879642009735,
0.14243170619010925,
-0.02110392414033413,
-0.2768409848213196,
0.060551390051841736,
-0.08093364536762238,
-0.17873097956180573,
-0.11601077765226364,
0.04333237186074257,
0.17910422384738922,
0.08741264790296555,
0.009637094102799892,
-0.051922865211963654,
-0.15446558594703674,
0.14443786442279816,
-0.038533344864845276,
-0.07875364273786545,
0.39852654933929443,
-0.03131088986992836,
0.013090289197862148,
-0.11766336113214493,
-0.09616564214229584,
-0.012197389267385006,
0.1074308529496193,
0.03626969829201698,
0.13366097211837769,
0.20956918597221375,
-0.031087756156921387,
0.036940865218639374,
-0.014681699685752392,
-0.26229172945022583,
0.04515071585774422,
0.19854116439819336,
-0.17559514939785004,
-0.2749283015727997,
-0.31185126304626465,
0.08231807500123978,
0.169326514005661,
-0.11078418046236038,
-0.07534525543451309,
-0.029917126521468163,
-0.13492028415203094,
0.2705543041229248,
0.0924745425581932,
-0.2953074872493744,
0.06809470802545547,
0.08231408149003983,
0.018574407324194908,
0.06462708115577698,
0.1068495661020279,
-0.05903850123286247,
-0.14514517784118652,
-0.0468924380838871,
-0.028723623603582382,
0.022611157968640327,
0.21270966529846191,
0.4074193239212036,
-0.03298254311084747,
0.1272469460964203,
-0.08271085470914841,
-0.0639958530664444,
-0.27875444293022156,
-0.04477600008249283,
0.17511962354183197,
0.0639907717704773,
-0.15685880184173584,
0.031028712168335915,
-0.07471194118261337,
0.07602095603942871,
-0.18079344928264618,
-0.043683938682079315,
-0.047787588089704514
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. urinalysis with 2+ proteinuria and hypoalbuminemia, ANA of 1:1080 with speckled pattern, and a positive anti-dsDNA .Of two sibs reported by Klar et al :A girl age eight years had Raynaud's phenomenon, a positive ANA (1:1280; homogenous pattern), a positive anti ds-DNA >1:160, positive anti-ENA, anti-RNP and anti-Smith;Her brother, age 12 years, had Raynaud's phenomenon, a positive ANA (1:40; homogeneous) and anti ds-DNA (1.6 μg/mL), and low C3 (30-74 mg/dL).An individual with positive ANA and anti-dsDNA titers, as well as low complement levels had no hematologic, renal, or articular problems; although he was given a diagnosis of SLE, he did not fulfill ACR diagnostic criteria .Falik | [
-0.005204777233302593,
-0.03368084877729416,
0.020178157836198807,
-0.08741778135299683,
0.10029789060354233,
0.16301202774047852,
-0.3585321009159088,
-0.04640001058578491,
-0.04919170215725899,
-0.3386334776878357,
0.17556601762771606,
-0.1415814310312271,
0.15194614231586456,
-0.1041870191693306,
-0.2565396726131439,
0.12067537754774094,
-0.08131488412618637,
-0.005076437257230282,
-0.03039833903312683,
0.034063953906297684,
0.07067915797233582,
-0.26621145009994507,
0.2668600380420685,
0.3169468939304352,
0.10956845432519913,
-0.17249742150306702,
-0.29314398765563965,
0.11025197058916092,
0.07000043243169785,
0.224405437707901,
-0.034801945090293884,
0.008556030690670013,
-0.008258233778178692,
0.30243638157844543,
-0.023854313418269157,
-0.061414849013090134,
-0.35852789878845215,
-0.1131228432059288,
0.2296556681394577,
0.07892793416976929,
-0.10372963547706604,
-0.04563584178686142,
0.20761196315288544,
0.21756121516227722,
-0.08820268511772156,
-0.27953460812568665,
0.05623646453022957,
-0.11743813753128052,
-0.22424964606761932,
-0.09299179911613464,
0.1947137862443924,
0.08594804257154465,
-0.231049582362175,
0.30872276425361633,
0.05938972532749176,
0.10593444108963013,
0.01208752766251564,
0.23271547257900238,
-0.18130818009376526,
-0.08287687599658966,
-0.14491966366767883,
0.17675141990184784,
-0.004506445024162531,
-0.13763639330863953,
0.37972745299339294,
-0.18821284174919128,
0.08314930647611618,
0.3064568042755127,
-0.10989231616258621,
0.06712450087070465,
0.08678574860095978,
-0.2416243702173233,
0.13333837687969208,
-0.09302030503749847,
-0.03923184424638748,
0.3432370722293854,
0.16822026669979095,
-0.15114609897136688,
0.048152677714824677,
-0.26328206062316895,
0.1405978500843048,
0.0008359678904525936,
-0.09359019994735718,
0.3690519630908966,
-0.061767444014549255,
-0.027712197974324226,
-0.02513582818210125,
0.07477550208568573,
0.024228310212492943,
-0.1332320123910904,
-0.07142622023820877,
-0.17731626331806183,
-0.19311237335205078,
-0.017556531354784966,
0.02875591069459915,
-0.11792400479316711,
-0.1529533565044403,
-0.23126862943172455,
0.0010832671541720629,
0.04064438119530678,
0.10365917533636093,
0.06623512506484985,
-0.03160315006971359,
-0.3342098295688629,
-0.2312231808900833,
-0.16108369827270508,
-0.09764273464679718,
-0.10661868751049042,
-0.2560237646102905,
0.2793448269367218,
0.22251150012016296,
0.012886343523859978,
-0.17832745611667633,
0.12421279400587082,
-0.1771411895751953,
-0.12213340401649475,
0.16760499775409698,
0.11381512880325317,
-0.17142681777477264,
-0.16384567320346832,
0.12338335812091827,
-0.24583818018436432,
0.0719362273812294,
-0.06332502514123917,
-0.0345175601541996,
0.05850411206483841,
-0.06050105392932892,
-0.19632048904895782,
0.11846930533647537,
-0.046493519097566605,
0.003340073861181736,
-0.12842242419719696,
-0.09589341282844543,
-0.3673906624317169,
0.15313217043876648,
-0.3712146580219269,
0.1888880580663681,
-0.21120844781398773,
0.10738097131252289,
0.12241397798061371,
-0.1719134896993637,
0.018087632954120636,
0.2353145331144333,
0.127177894115448,
-0.20322424173355103,
-0.2960803210735321,
0.3402252197265625,
-0.05783179774880409,
-0.0922623798251152,
0.0764421820640564,
0.39422672986984253,
-0.4253290891647339,
0.38630545139312744,
-0.018063321709632874,
-0.24304312467575073,
0.10980886965990067,
0.09043190628290176,
0.14222723245620728,
-0.39087221026420593,
-0.11638062447309494,
0.10547732561826706,
0.12725506722927094,
-0.08511025458574295,
-0.3108534514904022,
0.12979018688201904,
-0.07493438571691513,
0.18404537439346313,
-0.2640220522880554,
0.32955455780029297,
0.05669335648417473,
-0.017667535692453384,
-0.15359562635421753,
-0.14196281135082245,
-0.02280842699110508,
0.34194883704185486,
0.05517600476741791,
-0.15936212241649628,
0.0468561053276062,
-0.008908893913030624,
-0.03974069282412529,
0.02184748649597168,
-0.07574373483657837,
0.04569423943758011,
-0.23880635201931,
-0.11815504729747772,
-0.5355832576751709,
-0.10059721767902374,
0.04721834138035774,
-0.054277293384075165,
0.04023301601409912,
0.23753951489925385,
-0.02322760410606861,
-0.16488425433635712,
-0.3278866708278656,
-0.1562402993440628,
-0.015207001008093357,
0.01746227964758873,
0.04724734649062157,
0.03920453414320946,
0.036069195717573166,
0.1522526741027832,
0.088882215321064,
0.016509531065821648,
0.1152152568101883,
-0.006272393278777599,
0.35494759678840637,
-0.20869797468185425,
0.000623211613856256,
-0.10636652261018753,
0.3215615451335907,
0.25029468536376953,
-0.03669433668255806,
0.053214181214571,
0.1863054633140564,
0.001977805281057954,
-0.09818515181541443,
-0.10988757014274597,
0.07972339540719986,
0.2288784235715866,
0.09886343777179718,
-0.12576697766780853,
-0.1847822517156601,
-0.04291057959198952,
-0.3105870485305786,
-0.09293665736913681,
0.06321574002504349,
-0.07375182211399078,
-0.058835145086050034,
-0.030851248651742935,
0.0757412537932396,
-0.20840154588222504,
0.06006253883242607,
-0.04263503476977348,
0.04491863399744034,
-0.35447245836257935,
-0.1809341311454773,
-0.09425831586122513,
0.03315511718392372,
0.07864753901958466,
0.1729101836681366,
-0.08482193946838379,
0.021803179755806923,
0.04281846061348915,
0.037408385425806046,
-0.09387163817882538,
-0.016722647473216057,
0.005756052676588297,
-0.2744612693786621,
0.0035893567837774754,
0.1020970568060875,
-0.048741452395915985,
-0.05424536019563675,
-0.04740254580974579,
-0.08065221458673477,
-0.3562445044517517,
-0.0005756905302405357,
0.20183061063289642,
-0.11431611329317093,
-0.05164671316742897,
-0.037811048328876495,
0.08105867356061935,
0.3397579491138458,
-0.06482108682394028,
-0.09008020162582397,
-0.07492215186357498,
0.04666302353143692,
-0.15409545600414276,
-0.0565088726580143,
0.12931737303733826,
-0.10323071479797363,
0.007381632924079895,
0.2976189851760864,
0.2448713481426239,
0.07791146636009216,
0.06776708364486694,
-0.01851082779467106,
-0.2284514158964157,
-0.017626507207751274,
0.22252953052520752,
-0.49906080961227417,
0.07570378482341766,
-0.2093658298254013,
-0.15206825733184814,
-0.2443566620349884,
0.3767475485801697,
0.16656070947647095,
0.04839843511581421,
0.27825507521629333,
0.1361011415719986,
-0.14838376641273499,
0.02952781319618225,
0.20724758505821228,
-0.1678730845451355,
0.11112532019615173,
-0.04896615073084831,
-0.1195504292845726,
0.013454008847475052,
-0.15432603657245636,
0.30614110827445984,
0.12608370184898376,
0.27900320291519165,
0.14141228795051575,
-0.15977495908737183,
0.08340355008840561,
0.031210849061608315,
0.05086710304021835,
0.17305518686771393,
0.2829760015010834,
-0.05834668502211571,
0.22827638685703278,
-0.19275827705860138,
-0.06768841296434402,
-0.09303000569343567,
-0.17785653471946716,
0.04141248017549515,
-0.12640826404094696,
-0.12838862836360931,
0.12187891453504562,
0.21169209480285645,
0.08876731991767883,
0.16743208467960358,
0.0353643000125885,
0.07448826730251312,
0.025403613224625587,
0.0061934529803693295,
0.1366438865661621,
-0.15983615815639496,
0.10263203829526901,
-0.15889959037303925,
0.1354919821023941,
0.13716119527816772,
0.13501259684562683,
-0.21255861222743988,
-0.36791467666625977,
-0.1121174544095993,
-0.022776562720537186,
0.2964737117290497,
-0.03324226662516594,
-0.03634170815348625,
-0.2842608094215393,
0.0747251883149147,
-0.2431320697069168,
0.0354020893573761,
-0.19223354756832123,
0.13426291942596436,
-0.2605222165584564,
-0.0652858093380928,
-0.014126410707831383,
-0.05038768798112869,
-0.08837249875068665,
-0.25650984048843384,
-0.03684784844517708,
0.030324656516313553,
0.11760614812374115,
0.08093859255313873,
0.05672156438231468,
0.0622415617108345,
0.10823596268892288,
-0.016138803213834763,
-0.39607053995132446,
-0.015212124213576317,
0.08105432987213135,
-0.0006645456305705011,
0.05425523966550827,
0.05587739869952202,
0.17042769491672516,
0.1099211797118187,
0.061209555715322495,
0.10908786207437515,
0.028381606563925743,
-0.004757228773087263,
0.1467977613210678,
0.32840442657470703,
-0.13768069446086884,
0.07359594106674194,
0.06306848675012589,
-0.29808977246284485,
0.265544593334198,
-0.07437294721603394,
0.06430754065513611,
-0.07513102144002914,
0.2694826126098633,
0.12942785024642944,
0.06105467304587364,
0.01975242979824543,
0.07940372079610825,
-0.0032864173408597708,
0.03079034574329853,
-0.1899903416633606,
-0.2894732654094696,
0.3469967544078827,
0.2750295102596283,
0.1855323612689972,
0.14100168645381927,
-0.07933596521615982,
0.06499277800321579,
-0.23465238511562347,
-0.16414454579353333,
-0.3425474464893341,
-0.08003151416778564,
-0.21886049211025238,
-0.2227671891450882,
0.05922919884324074,
0.19977210462093353,
0.22974273562431335,
-0.055084023624658585,
-0.04740968719124794,
-0.13918502628803253,
0.29248037934303284,
0.03166323900222778,
-0.09915768355131149,
0.1072561964392662,
-0.18904192745685577,
-0.09252132475376129,
0.0640425905585289,
0.032926201820373535,
-0.08362118899822235,
0.21069815754890442,
0.17991013824939728,
-0.1845199465751648,
-0.07354001700878143,
0.13795194029808044,
0.25265467166900635,
-0.0939222127199173,
-0.025974208489060402,
0.04912860319018364,
0.16499266028404236,
-0.06238782778382301,
0.26011013984680176,
0.21792945265769958,
0.25271785259246826,
0.059903334826231,
-0.25235751271247864,
0.23482845723628998,
0.017624279484152794,
0.01560160517692566,
0.25896039605140686,
-0.09683582931756973,
0.3997528553009033,
0.16717654466629028,
0.31130415201187134,
0.18937088549137115,
-0.17495711147785187,
-0.011911405250430107,
-0.033150844275951385,
0.14498445391654968,
-0.05182821676135063,
-0.04457259923219681,
0.18022671341896057,
0.0002458677045069635,
0.021398965269327164,
-0.09086736291646957,
0.14455929398536682,
0.014522256329655647,
-0.16275128722190857,
-0.37284281849861145,
0.09740757197141647,
-0.03978298231959343,
-0.11389827728271484,
0.10519316792488098,
0.05292749032378197,
0.16431696712970734,
0.10630433261394501,
-0.10412797331809998,
0.10176799446344376,
0.27258628606796265,
0.0469789132475853,
-0.18210674822330475,
-0.014539629220962524,
-0.009262844920158386,
0.016463883221149445,
-0.0732964351773262,
0.01957683078944683,
-0.2542533278465271,
-0.17799879610538483,
-0.1527329683303833,
0.39534232020378113,
0.10173206776380539,
0.0546075813472271,
0.15360435843467712,
0.2157311588525772,
-0.0016765723703429103,
-0.23680774867534637,
0.26351454854011536,
0.07372091710567474,
-0.0059557645581662655,
-0.1777387410402298,
-0.009274804033339024,
0.09639492630958557,
-0.21762235462665558,
0.0036736377514898777,
0.03559408336877823,
-0.19641678035259247,
0.41269415616989136,
-0.08856585621833801,
-0.10976836830377579,
0.09099860489368439,
-0.0803058072924614,
0.058888666331768036,
-0.13128378987312317,
0.2935413122177124,
0.026384728029370308,
0.2295977771282196,
0.08398184925317764,
0.0038385496009141207,
-0.05377815291285515,
-0.11384732276201248,
-0.0313381664454937,
0.23541159927845,
0.05553782731294632,
0.1509171575307846,
-0.07703010737895966,
0.06669699400663376,
-0.4721483290195465,
0.0706099271774292,
-0.16250792145729065,
0.2589554786682129,
0.39557310938835144,
0.24776381254196167,
-0.013991275802254677,
0.0786406472325325,
-0.31110742688179016,
-0.13940657675266266,
0.10071979463100433,
0.1074817031621933,
-0.2038622498512268,
0.044825393706560135,
-0.20131751894950867,
0.12180741131305695,
-0.28256043791770935,
-0.029383845627307892,
0.009220264852046967,
-0.2036091685295105,
0.20068930089473724,
0.26455292105674744,
-0.18456202745437622,
-0.0643632560968399,
0.10824856907129288,
0.12219341844320297,
0.03196962550282478,
0.20820879936218262,
-0.10872460156679153,
0.2090989202260971,
-0.18720100820064545,
0.008670623414218426,
-0.1208646148443222,
-0.11687751859426498,
0.1565106064081192,
-0.03633907064795494,
-0.11468543112277985,
-0.07736445963382721,
0.15025590360164642,
-0.05436224490404129,
-0.11468888074159622,
-0.2993088662624359,
0.1442946344614029,
0.07150289416313171,
-0.09248284995555878,
-0.03355434909462929,
0.05058489367365837,
0.1229112446308136,
-0.1832825243473053,
-0.19782288372516632,
0.12541934847831726,
-0.20494861900806427,
-0.08044085651636124,
0.07454140484333038,
0.06443514674901962,
-0.2697651982307434,
-0.0809485986828804,
-0.21580864489078522,
-0.1951826810836792,
0.05275912582874298,
0.11710907518863678,
-0.08491085469722748,
0.07166367769241333,
-0.07608896493911743,
0.1050453782081604,
-0.16165512800216675,
0.09208563715219498,
-0.39122727513313293,
-0.25605642795562744,
0.054171450436115265,
0.1480383276939392,
-0.018991058692336082,
-0.3356247544288635,
-0.2223883867263794,
-0.05012119188904762,
-0.08425500243902206,
-0.13953638076782227,
0.0952158272266388,
0.03266734257340431,
-0.1015491932630539,
-0.02181587554514408,
0.16804605722427368,
0.10921777039766312,
0.17547079920768738,
0.10904595255851746,
-0.031327977776527405,
-0.03780568018555641,
0.03902069106698036,
-0.21735446155071259,
-0.0009631534921936691,
-0.32372188568115234,
0.013157621026039124,
0.14475829899311066,
0.08463377505540848,
-0.07757197320461273,
0.37741556763648987,
-0.19310308992862701,
0.11193423718214035,
-0.08257950842380524,
0.18537089228630066,
-0.27149641513824463,
0.08314340561628342,
-0.018979134038090706,
-0.10282953083515167,
-0.22800345718860626,
-0.1547832190990448,
-0.08931625634431839,
0.09453235566616058,
0.0511273555457592,
-0.17898449301719666,
0.025536051020026207,
-0.07200591266155243,
0.26176708936691284,
0.2628922164440155,
-0.14528551697731018,
0.17148669064044952,
0.022684084251523018,
-0.09613554924726486,
0.14216648042201996,
-0.10765500366687775,
-0.1052587702870369,
-0.07039739191532135,
0.020527726039290428,
0.15157751739025116,
0.29054689407348633,
-0.04402903467416763,
0.09937087446451187,
-0.04295293241739273,
-0.12001507729291916,
0.01999231055378914,
0.05602037161588669,
-0.016263898462057114,
0.19690804183483124,
-0.17427685856819153,
-0.32553133368492126,
0.18523208796977997,
0.06143547222018242,
0.16276630759239197,
0.07717137038707733,
0.2807687222957611,
-0.21081046760082245,
-0.29347532987594604,
-0.14495666325092316,
-0.04370659589767456,
-0.017844518646597862,
0.20472411811351776,
-0.5014855265617371,
0.03522301837801933,
-0.15646806359291077,
-0.2886904776096344,
0.27014556527137756,
0.07326971739530563,
-0.24837082624435425,
0.03651673346757889,
0.0018329055747017264,
0.18563643097877502,
-0.07177146524190903,
0.15211458504199982,
-0.012967153452336788,
0.04338908940553665,
0.028487473726272583,
-0.13474857807159424,
0.13796719908714294,
0.06870029866695404,
-0.05294942110776901,
0.03125516325235367,
0.22838474810123444,
-0.05221754312515259,
-0.04522241652011871,
0.24119266867637634,
0.1617017239332199,
0.052714891731739044,
0.044502392411231995,
-0.09037445485591888,
-0.03195082023739815,
0.11771822720766068,
-0.16120055317878723,
-0.2506525218486786,
0.002478812588378787,
0.1063908040523529,
-0.25550514459609985,
-0.16772396862506866,
0.051517367362976074,
0.15672795474529266,
0.21195431053638458,
-0.049921050667762756,
-0.17512407898902893,
0.04245394468307495,
-0.006921522784978151,
-0.12419704347848892,
-0.1813347190618515,
0.09210347384214401,
0.18612851202487946,
0.08183149248361588,
0.019430799409747124,
-0.034702375531196594,
-0.1773393303155899,
0.26312974095344543,
-0.05985619127750397,
-0.11757856607437134,
0.4322482645511627,
0.01829090528190136,
-0.10580980032682419,
-0.17769978940486908,
0.01991630531847477,
0.05779508873820305,
0.01599707081913948,
0.13963603973388672,
0.12446266412734985,
0.2498374581336975,
0.03569647669792175,
0.08207076042890549,
0.051936905831098557,
-0.24033533036708832,
0.1837252825498581,
0.2422994077205658,
-0.17558178305625916,
-0.271392285823822,
-0.34603050351142883,
0.2287878692150116,
0.05407743901014328,
-0.12423527985811234,
0.02870701067149639,
-0.005354335065931082,
-0.059343039989471436,
0.19738849997520447,
0.11956365406513214,
-0.2576438784599304,
-0.05485770106315613,
0.032013192772865295,
0.21788695454597473,
0.011963034979999065,
0.05904485285282135,
-0.0669318214058876,
-0.0941825658082962,
-0.07221265882253647,
0.04193757846951485,
0.036467794328927994,
0.19532229006290436,
0.43926459550857544,
0.0025532024446874857,
0.0683969184756279,
0.022169137373566628,
-0.043516263365745544,
-0.3131505250930786,
-0.14756610989570618,
0.23480449616909027,
0.010439892299473286,
-0.2826736867427826,
0.08292631059885025,
0.051106907427310944,
0.09332781285047531,
-0.20379610359668732,
-0.04301649332046509,
-0.021727293729782104
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. ;Her brother, age 12 years, had Raynaud's phenomenon, a positive ANA (1:40; homogeneous) and anti ds-DNA (1.6 μg/mL), and low C3 (30-74 mg/dL).An individual with positive ANA and anti-dsDNA titers, as well as low complement levels had no hematologic, renal, or articular problems; although he was given a diagnosis of SLE, he did not fulfill ACR diagnostic criteria .Falik-Zaccai et al reported two individuals:One with Coombs-positive hemolytic anemia, severe medication-resistant thrombocytopenia which required splenectomy, high levels of ANA and anti-cardiolipin antibodies, and a strongly positive anti-dsDNA;One with aphthous stomatitis, macroscopic hematuria and proteinuria eventually leading to renal failure (with a renal biopsy compatible with lupus nephritis), seizures, pancytopenia, Coombs-positive hemolytic anemia, hypocomplementemia | [
-0.028215844184160233,
-0.1167823001742363,
-0.03444742411375046,
-0.23452064394950867,
0.028668122366070747,
0.19520996510982513,
-0.36499401926994324,
-0.061571259051561356,
-0.09921726584434509,
-0.49079859256744385,
0.2016441524028778,
-0.17416061460971832,
0.0711665228009224,
-0.1632051169872284,
-0.11894689500331879,
0.23829269409179688,
-0.05461328104138374,
0.005079356953501701,
0.03504092991352081,
0.05657491832971573,
-0.02610846981406212,
-0.22614163160324097,
0.11992241442203522,
0.16469374299049377,
0.24501127004623413,
-0.2815417945384979,
-0.014405010268092155,
-0.014827316626906395,
-0.04045308008790016,
0.20497043430805206,
-0.07211627811193466,
-0.05944567173719406,
0.04826096445322037,
0.18316233158111572,
-0.04798601567745209,
-0.012016857974231243,
-0.31929951906204224,
-0.22329963743686676,
0.2704979181289673,
0.09603030234575272,
-0.13118842244148254,
-0.08557333052158356,
0.11190621554851532,
0.15483888983726501,
-0.1262703686952591,
-0.2619172930717468,
-0.0805593729019165,
-0.07028473913669586,
-0.15109466016292572,
-0.0005657084984704852,
0.08749453723430634,
0.0868326723575592,
-0.16026528179645538,
0.06310505419969559,
0.035776086151599884,
-0.0245928093791008,
-0.03036535158753395,
0.15650442242622375,
-0.0931210070848465,
0.04189067333936691,
-0.10416461527347565,
0.19519604742527008,
0.0549078993499279,
-0.17832165956497192,
0.25600874423980713,
-0.11165401339530945,
0.04251689091324806,
0.16357150673866272,
-0.097945936024189,
0.026580097153782845,
0.07388392090797424,
-0.24960245192050934,
0.13012558221817017,
-0.06413759291172028,
-0.022256601601839066,
0.264422744512558,
0.05827704071998596,
-0.09188756346702576,
0.11055997759103775,
-0.22923199832439423,
0.05218309536576271,
-0.01878918893635273,
-0.1479613035917282,
0.33358246088027954,
-0.10947556048631668,
-0.03176542744040489,
-0.05652796849608421,
0.03366434574127197,
-0.1418742686510086,
-0.21544522047042847,
-0.014623102732002735,
-0.10933412611484528,
-0.12519247829914093,
0.1112949475646019,
-0.0030570905655622482,
-0.15000315010547638,
-0.08202886581420898,
-0.18569238483905792,
-0.021163765341043472,
0.009506883099675179,
-0.021882573142647743,
0.05266929045319557,
-0.012815247289836407,
-0.1709904670715332,
-0.21253156661987305,
-0.12026701867580414,
-0.052757348865270615,
-0.14284412562847137,
-0.25925254821777344,
0.2917643189430237,
0.4713570177555084,
0.015132056549191475,
-0.14805884659290314,
0.06680966913700104,
-0.20978672802448273,
-0.10315940529108047,
0.10037489235401154,
-0.005430674646049738,
-0.23176850378513336,
-0.05180686339735985,
0.008396272547543049,
-0.157998725771904,
0.13046982884407043,
-0.03748532012104988,
0.048064395785331726,
0.03934170678257942,
-0.12200994044542313,
-0.3537963628768921,
0.09980862587690353,
0.073053278028965,
-0.010450424626469612,
-0.06547937542200089,
-0.049158357083797455,
-0.3500155806541443,
0.07839642465114594,
-0.3899717926979065,
0.15641678869724274,
-0.24351292848587036,
0.19098778069019318,
0.10933361202478409,
-0.11820913106203079,
-0.04774360731244087,
0.3508360981941223,
0.20121054351329803,
-0.15965799987316132,
-0.314908504486084,
0.3356051743030548,
-0.021476319059729576,
-0.01213360857218504,
0.13487868010997772,
0.328714519739151,
-0.4027077853679657,
0.4177373945713043,
-0.005946844816207886,
-0.29175618290901184,
0.004747176542878151,
0.0870494619011879,
0.10968293994665146,
-0.38957008719444275,
-0.17378456890583038,
0.26781877875328064,
0.16842688620090485,
0.013050933368504047,
-0.35463520884513855,
0.12999305129051208,
-0.13286811113357544,
0.1302587389945984,
-0.2441629320383072,
0.38460251688957214,
-0.04177231341600418,
-0.04154501110315323,
-0.12069546431303024,
-0.10294252634048462,
0.014451287686824799,
0.3938431739807129,
0.12706120312213898,
-0.07633102685213089,
-0.05585217475891113,
-0.07036365568637848,
0.013484345749020576,
-0.09628264605998993,
0.0020276550203561783,
-0.012405207380652428,
-0.23579002916812897,
0.09193681180477142,
-0.5268425941467285,
-0.11551408469676971,
0.04832623153924942,
-0.004615601152181625,
-0.050551120191812515,
0.2557739019393921,
-0.1408589482307434,
-0.041644830256700516,
-0.2674983739852905,
0.02621813304722309,
-0.12380869686603546,
-0.07913855463266373,
-0.07520248740911484,
0.06184636801481247,
0.04415946826338768,
0.10595931112766266,
-0.06167292594909668,
-0.17173805832862854,
0.03968637436628342,
0.11633206158876419,
0.3453531563282013,
-0.012015742249786854,
0.02078155055642128,
-0.10745198279619217,
0.23593348264694214,
0.039150115102529526,
-0.06881962716579437,
-0.13017360866069794,
0.23661546409130096,
0.022974327206611633,
-0.043803635984659195,
-0.2430461347103119,
0.004377198405563831,
0.2768835723400116,
0.12126419693231583,
-0.0069339280016720295,
-0.03301020711660385,
-0.09729191660881042,
-0.3068421483039856,
-0.08211842179298401,
-0.06157899275422096,
-0.0014035406056791544,
-0.2698306739330292,
-0.08066324144601822,
0.048848818987607956,
-0.2143675684928894,
0.15204355120658875,
-0.17467641830444336,
0.12190969288349152,
-0.3773163855075836,
-0.18395765125751495,
-0.03881898894906044,
0.07872692495584488,
0.11882782727479935,
0.14343737065792084,
-0.14140133559703827,
0.15744206309318542,
0.03642214462161064,
0.045872095972299576,
-0.24065837264060974,
-0.13690878450870514,
0.009056626819074154,
-0.25397345423698425,
0.015303862281143665,
0.16950128972530365,
-0.14130517840385437,
-0.10669612139463425,
-0.10652011632919312,
-0.04943472892045975,
-0.4744188189506531,
-0.057165034115314484,
0.24528342485427856,
-0.07431434839963913,
0.0284032691270113,
-0.03479962423443794,
0.1093713715672493,
0.1788618266582489,
-0.015488587319850922,
-0.22118216753005981,
-0.026383310556411743,
0.0025536678731441498,
-0.20572727918624878,
0.04027092084288597,
0.09865772724151611,
-0.13935735821723938,
0.03768933191895485,
0.2377007007598877,
0.15670694410800934,
-0.05602137744426727,
0.08683447539806366,
-0.04318901523947716,
-0.09616091847419739,
0.10711592435836792,
0.1421211063861847,
-0.3554767668247223,
0.2599067687988281,
-0.09356587380170822,
-0.11111008375883102,
-0.10650084167718887,
0.5026258826255798,
0.24544237554073334,
-0.035146184265613556,
0.18198777735233307,
0.0926196277141571,
-0.06162422522902489,
-0.0003339767281431705,
0.19247928261756897,
-0.08294045180082321,
0.00476610753685236,
0.02362612821161747,
-0.03838098794221878,
0.16231566667556763,
-0.1038706973195076,
0.1128167137503624,
0.03645874932408333,
0.1036437526345253,
0.23534457385540009,
-0.2337779998779297,
-0.028416190296411514,
-0.0214268509298563,
-0.0444493405520916,
0.1827673465013504,
0.22739975154399872,
0.14503875374794006,
0.27781161665916443,
-0.27986714243888855,
-0.10359300673007965,
0.013357066549360752,
-0.12431646883487701,
-0.055651530623435974,
0.10039879381656647,
-0.07445964962244034,
0.12740209698677063,
0.17645294964313507,
0.1305873543024063,
0.2134169042110443,
-0.07590538263320923,
0.12461420148611069,
0.0012170557165518403,
0.14217884838581085,
0.12650635838508606,
-0.29414770007133484,
0.09282620251178741,
-0.13025256991386414,
0.00546738225966692,
0.19164352118968964,
-0.012989221140742302,
-0.10179193317890167,
-0.18890008330345154,
-0.0009648557752370834,
0.013677569106221199,
0.1857527494430542,
-0.12045685946941376,
-0.07346939295530319,
-0.523493766784668,
0.18020832538604736,
-0.3765368163585663,
0.015207654796540737,
-0.09354212880134583,
0.15647199749946594,
-0.16142664849758148,
-0.06341023743152618,
0.0792769342660904,
-0.02188192680478096,
-0.1260368824005127,
-0.11623954027891159,
0.040013980120420456,
0.01029015053063631,
0.008607118390500546,
0.10238255560398102,
0.004511968232691288,
0.09424901008605957,
0.09063168615102768,
-0.019430680200457573,
-0.35864466428756714,
-0.01840144395828247,
0.20160891115665436,
0.000054539235861739144,
0.06931085884571075,
0.16153177618980408,
0.17047667503356934,
0.14278675615787506,
-0.0782567635178566,
0.12590090930461884,
-0.08348383754491806,
-0.13197004795074463,
0.18427225947380066,
0.3276922106742859,
-0.09151088446378708,
-0.19031256437301636,
0.08400654792785645,
-0.2432740181684494,
0.24107590317726135,
-0.22318151593208313,
0.09117405116558075,
-0.1492447555065155,
0.2003796100616455,
0.04837507754564285,
0.03663567453622818,
0.06275149434804916,
0.10601270943880081,
-0.23042497038841248,
0.013837859034538269,
-0.17004483938217163,
-0.3055915832519531,
0.3480924367904663,
0.21422980725765228,
0.2940877079963684,
0.04781249165534973,
-0.06087736040353775,
0.10091614723205566,
-0.18043917417526245,
-0.2932039201259613,
-0.24650487303733826,
-0.231307715177536,
0.024026181548833847,
-0.20481310784816742,
0.12971942126750946,
0.38622748851776123,
0.19492115080356598,
-0.08502410352230072,
-0.13275684416294098,
-0.20562368631362915,
0.022770099341869354,
-0.027935829013586044,
-0.13037359714508057,
-0.028722941875457764,
-0.16898120939731598,
-0.15133920311927795,
0.01984935812652111,
0.09789890050888062,
-0.09897283464670181,
0.13606314361095428,
0.11483585834503174,
-0.22933299839496613,
-0.05120818689465523,
0.16405871510505676,
0.18424825370311737,
-0.208436980843544,
0.008174259215593338,
-0.002873024670407176,
0.03934263437986374,
0.02123033069074154,
0.18799085915088654,
0.2705700695514679,
0.3427121639251709,
0.08366046100854874,
-0.2709394097328186,
0.2996401786804199,
0.015307561494410038,
0.05735677853226662,
0.27200499176979065,
-0.09532002359628677,
0.30667173862457275,
0.029689965769648552,
0.35573315620422363,
0.23079447448253632,
-0.1378745585680008,
0.12260709702968597,
-0.01670468971133232,
0.2037934958934784,
-0.09505148231983185,
0.10895397514104843,
0.16825221478939056,
-0.04102299362421036,
0.16148968040943146,
-0.2656927704811096,
0.2169998586177826,
0.08702705800533295,
-0.22479040920734406,
-0.33445122838020325,
0.03822002932429314,
-0.09954565018415451,
-0.13150271773338318,
0.05649847909808159,
-0.18986788392066956,
0.12276902794837952,
0.15451551973819733,
-0.1659265011548996,
0.18878868222236633,
0.21625493466854095,
-0.07332537323236465,
-0.0325823612511158,
-0.0668545588850975,
0.07702986896038055,
0.05178416520357132,
-0.1474829763174057,
0.09796538949012756,
-0.22289609909057617,
-0.11712424457073212,
-0.05281683802604675,
0.3635336756706238,
0.0873510092496872,
0.04103459417819977,
0.1453341245651245,
0.15334589779376984,
0.05870601534843445,
-0.10694631934165955,
0.16852721571922302,
0.0682012215256691,
0.007530199363827705,
-0.19913379848003387,
-0.005769367795437574,
0.08652748167514801,
-0.2576281726360321,
0.09957701712846756,
0.05496395006775856,
-0.07931315153837204,
0.4901933968067169,
-0.11977197974920273,
0.015875814482569695,
0.004347383510321379,
-0.09060897678136826,
0.14502492547035217,
-0.019915631040930748,
0.15799488127231598,
-0.02750237286090851,
0.1770445853471756,
0.010420731268823147,
0.05148165673017502,
0.0508272685110569,
-0.1958760768175125,
-0.028461117297410965,
0.1815173327922821,
0.07230790704488754,
0.15544378757476807,
0.03963558375835419,
0.1597442477941513,
-0.4762990474700928,
-0.003541315207257867,
-0.1037353128194809,
0.15913142263889313,
0.3028732240200043,
0.1937444806098938,
-0.024097904562950134,
0.04059088975191116,
-0.2300788164138794,
-0.1524766981601715,
0.039165496826171875,
-0.05017818510532379,
-0.16522547602653503,
0.035766489803791046,
-0.07826805114746094,
0.16928385198116302,
-0.2653912901878357,
0.04400516301393509,
-0.06586508452892303,
-0.160221129655838,
0.28239044547080994,
0.48793745040893555,
-0.08421643823385239,
0.001435619778931141,
0.032162681221961975,
0.07058478146791458,
0.058584243059158325,
0.1708344668149948,
0.03760938718914986,
0.3091173470020294,
-0.1328575760126114,
-0.15665826201438904,
0.03031078539788723,
-0.08812210708856583,
0.1528688371181488,
0.0016913872677832842,
0.03094038926064968,
-0.050711456686258316,
0.18408119678497314,
0.05884972959756851,
-0.13837839663028717,
-0.16422916948795319,
0.1604757457971573,
0.08162926882505417,
-0.186552956700325,
0.15083147585391998,
0.033297181129455566,
0.012835465371608734,
-0.14956942200660706,
-0.09405471384525299,
0.07353965938091278,
-0.14473606646060944,
-0.11173716932535172,
0.11516693234443665,
0.019552135840058327,
-0.3830530643463135,
-0.1435391753911972,
-0.1656859964132309,
-0.2377942055463791,
0.03186190873384476,
0.1486527919769287,
-0.020821595564484596,
0.04140511900186539,
0.02456715516746044,
0.21439340710639954,
-0.06082480400800705,
-0.0993155911564827,
-0.1672021895647049,
-0.3070930540561676,
0.1835014671087265,
0.14423911273479462,
-0.14154742658138275,
-0.22354517877101898,
-0.33869415521621704,
-0.03398507833480835,
-0.103096604347229,
-0.03704121708869934,
0.10592196136713028,
-0.022655321285128593,
-0.05448468402028084,
-0.10432843118906021,
0.3072846233844757,
0.12242689728736877,
0.08775395900011063,
-0.028433239087462425,
0.024752302095294,
0.02065456286072731,
-0.06482702493667603,
0.03274038806557655,
0.10802379995584488,
-0.33645784854888916,
0.06300963461399078,
0.18688595294952393,
0.04712395370006561,
0.06582516431808472,
0.462002694606781,
-0.1358879655599594,
0.17447519302368164,
-0.027902161702513695,
0.17318573594093323,
-0.2017577588558197,
0.007535129319876432,
0.011249417439103127,
-0.14352652430534363,
-0.30023038387298584,
-0.09721631556749344,
-0.11440751701593399,
0.15208007395267487,
0.20267559587955475,
-0.07330965995788574,
-0.013113301247358322,
-0.08976348489522934,
0.2778492271900177,
0.236123189330101,
-0.14905138313770294,
-0.03298153728246689,
-0.044165585190057755,
-0.0187845341861248,
0.040519870817661285,
-0.2165033370256424,
0.010363860055804253,
-0.0747237429022789,
0.021088670939207077,
0.05664529651403427,
0.3049722909927368,
0.17891596257686615,
0.021592969074845314,
-0.12029217928647995,
-0.13812628388404846,
-0.2098381370306015,
0.16599629819393158,
-0.03370368480682373,
0.3209216594696045,
-0.14207793772220612,
-0.303915798664093,
0.13559359312057495,
0.06058873236179352,
0.09455042332410812,
0.0015373766655102372,
0.1236853301525116,
-0.24453815817832947,
-0.20139272511005402,
-0.15527157485485077,
-0.1334903985261917,
0.09564331918954849,
0.21231812238693237,
-0.2625233829021454,
0.052637577056884766,
0.00765498261898756,
-0.21133269369602203,
0.3193706274032593,
0.04195199906826019,
-0.24964408576488495,
-0.03726089373230934,
-0.11544138938188553,
0.23022869229316711,
0.18223896622657776,
0.028163325041532516,
0.07684589922428131,
0.1401291787624359,
0.029079876840114594,
-0.09208528697490692,
-0.04889204353094101,
0.026430238038301468,
0.02437816746532917,
-0.032784488052129745,
0.33994656801223755,
0.00020997672982048243,
0.05524010211229324,
0.1977577656507492,
0.19811376929283142,
0.12071022391319275,
0.10454960912466049,
-0.11339922249317169,
0.06374124437570572,
0.115679532289505,
-0.11322104930877686,
-0.2204451709985733,
-0.11712247133255005,
0.08116930723190308,
-0.06788962334394455,
-0.08045888692140579,
0.0392637625336647,
0.26796701550483704,
0.25486692786216736,
-0.020276864990592003,
-0.07596692442893982,
-0.17394037544727325,
0.2008202075958252,
-0.19760583341121674,
-0.11938311159610748,
0.07516880333423615,
0.0931376963853836,
0.08603602647781372,
0.04772452265024185,
0.1130012646317482,
-0.06517615914344788,
0.19848968088626862,
-0.029278280213475227,
-0.0494384691119194,
0.41803398728370667,
-0.0005510704359039664,
-0.09665387123823166,
-0.2685844898223877,
0.11948350816965103,
0.0011586910113692284,
0.06641208380460739,
0.06145934388041496,
0.1193779855966568,
0.23913981020450592,
0.02089649625122547,
-0.015237501822412014,
-0.08035267889499664,
-0.176587775349617,
0.13187502324581146,
-0.008958679623901844,
-0.15930621325969696,
-0.3825318217277527,
-0.16244223713874817,
0.18879634141921997,
0.11333146691322327,
-0.17107145488262177,
0.2629008889198303,
0.05517887324094772,
-0.1783221811056137,
0.1219768300652504,
0.20216482877731323,
-0.24285459518432617,
0.04468337073922157,
0.029429197311401367,
0.21760393679141998,
-0.1434696912765503,
0.160911425948143,
-0.13671207427978516,
-0.025218959897756577,
-0.09211375564336777,
0.053201403468847275,
0.09838955104351044,
0.19291965663433075,
0.29714056849479675,
-0.07805301249027252,
0.030082808807492256,
0.10835602134466171,
-0.11464840918779373,
-0.24382023513317108,
-0.08992085605859756,
0.20323289930820465,
0.023458125069737434,
-0.1728391796350479,
0.11054783314466476,
-0.0009735840139910579,
0.08254922181367874,
-0.1827496588230133,
0.07205456495285034,
-0.12805204093456268
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. diagnostic criteria .Falik-Zaccai et al reported two individuals:One with Coombs-positive hemolytic anemia, severe medication-resistant thrombocytopenia which required splenectomy, high levels of ANA and anti-cardiolipin antibodies, and a strongly positive anti-dsDNA;One with aphthous stomatitis, macroscopic hematuria and proteinuria eventually leading to renal failure (with a renal biopsy compatible with lupus nephritis), seizures, pancytopenia, Coombs-positive hemolytic anemia, hypocomplementemia, and elevated ANA and anti-dsDNA antibodies).Butbul Aviel et al reported three individuals with the SLE/prolidase deficiency association:A boy age 4.5 years with a rash consistent with hypertrophic discoid lupus on biopsy, proteinuria and mild hematuria with a renal biopsy consistent with WHO Class IV lupus nephritis, low C3 and C4 levels, positive ANA (1:640; homogeneous pattern), anti ds-DNA, anti-RNP, anti- | [
-0.1444110870361328,
-0.06989597529172897,
0.01467894110828638,
-0.22528237104415894,
0.07729887217283249,
0.24616305530071259,
-0.34285733103752136,
-0.12930598855018616,
-0.0748647078871727,
-0.3954625427722931,
0.15298336744308472,
-0.0018675950122997165,
0.11253073066473007,
-0.14104142785072327,
-0.0920930877327919,
0.24721546471118927,
0.01232175063341856,
0.043350543826818466,
0.017145255580544472,
-0.08622338622808456,
-0.00377090647816658,
-0.2610451579093933,
0.21508058905601501,
0.23233845829963684,
0.23555679619312286,
-0.14094609022140503,
0.06878860294818878,
0.10797333717346191,
-0.05453653261065483,
0.18708375096321106,
0.03378812223672867,
-0.03604789450764656,
0.07012102007865906,
0.10038996487855911,
-0.01390337198972702,
-0.034744277596473694,
-0.31522950530052185,
-0.17378126084804535,
0.3443072736263275,
0.03505461663007736,
-0.11269962042570114,
0.07589960843324661,
0.20326557755470276,
0.2149905562400818,
-0.0435761883854866,
-0.2596088647842407,
-0.007639798801392317,
-0.02855459786951542,
-0.13462939858436584,
0.01743842102587223,
0.2688842713832855,
0.025229142978787422,
-0.14508947730064392,
0.014588012360036373,
0.13732020556926727,
0.11659268289804459,
-0.030128391459584236,
0.16324545443058014,
-0.004822254180908203,
0.07590010017156601,
-0.03658436983823776,
0.15843252837657928,
-0.03536257892847061,
-0.2663447856903076,
0.4334814250469208,
-0.16391411423683167,
0.12377499043941498,
0.1695777326822281,
-0.1147104874253273,
-0.02185351960361004,
0.23872272670269012,
-0.12721310555934906,
0.1773010790348053,
-0.06513725221157074,
-0.03475426509976387,
0.16741713881492615,
0.09548848867416382,
-0.08009961247444153,
0.12386001646518707,
-0.23898111283779144,
0.03520137071609497,
0.024033674970269203,
-0.07885244488716125,
0.2852834165096283,
-0.10724098980426788,
0.10777558386325836,
0.14263680577278137,
0.08030436933040619,
-0.11044138669967651,
-0.17532776296138763,
0.03328046202659607,
-0.24730849266052246,
-0.011187061667442322,
-0.002643293933942914,
-0.01612624153494835,
-0.07279258221387863,
-0.06253786385059357,
-0.19082796573638916,
-0.040633849799633026,
0.025934318080544472,
0.0347265861928463,
0.08183485269546509,
-0.08283785730600357,
-0.09118849784135818,
-0.10731568187475204,
-0.15270943939685822,
-0.07271451503038406,
-0.14439131319522858,
-0.2420019507408142,
0.14027361571788788,
0.3913474977016449,
-0.011744165793061256,
-0.1193227767944336,
0.046827711164951324,
-0.16329963505268097,
-0.03457125276327133,
0.08301988989114761,
-0.0402039960026741,
-0.25696954131126404,
-0.11763502657413483,
0.023706981912255287,
-0.13220015168190002,
0.03179898485541344,
-0.21100665628910065,
0.07129029929637909,
0.03457023575901985,
0.0540037602186203,
-0.2165011614561081,
0.13095955550670624,
0.0941297858953476,
0.09805642813444138,
0.07085343450307846,
-0.0598696731030941,
-0.3425513803958893,
-0.0609145350754261,
-0.1880713701248169,
-0.0249734278768301,
-0.22203660011291504,
0.08379757404327393,
0.049089543521404266,
-0.08685137331485748,
-0.0881475955247879,
0.3060549199581146,
0.3242652416229248,
-0.1088389977812767,
-0.17341254651546478,
0.4103468954563141,
-0.1224917471408844,
-0.03267282247543335,
0.15052947402000427,
0.1619904786348343,
-0.3519791066646576,
0.5017432570457458,
-0.0054837120696902275,
-0.29908353090286255,
-0.056641653180122375,
-0.01921789161860943,
0.08085537701845169,
-0.30392515659332275,
-0.16458266973495483,
0.2655794620513916,
0.1548963040113449,
0.03165505826473236,
-0.2578548789024353,
0.19783028960227966,
-0.14712101221084595,
0.051658596843481064,
-0.06644546240568161,
0.341050386428833,
0.09326664358377457,
-0.11599348485469818,
-0.09128729999065399,
0.08854081481695175,
0.04105008766055107,
0.2856345474720001,
0.021506112068891525,
-0.06165796518325806,
0.05435778573155403,
-0.0741228237748146,
-0.04524042084813118,
-0.10611554235219955,
0.003271554596722126,
0.05251599848270416,
-0.2847804129123688,
0.0625145360827446,
-0.3464018404483795,
-0.05075467750430107,
0.090045265853405,
-0.08667579293251038,
-0.04686446487903595,
0.19949109852313995,
-0.007673714775592089,
-0.11291759461164474,
-0.2726054787635803,
0.14176665246486664,
-0.26975932717323303,
-0.039913102984428406,
-0.04534606263041496,
-0.00871100090444088,
0.0013580291997641325,
0.1641640067100525,
-0.12937340140342712,
-0.17791737616062164,
0.08067132532596588,
0.09628497064113617,
0.2796512544155121,
-0.03067929483950138,
-0.03097197785973549,
-0.13826487958431244,
0.43085211515426636,
0.14162187278270721,
0.06986524909734726,
-0.14003393054008484,
0.3396993577480316,
-0.0210319422185421,
-0.026356657966971397,
-0.22097456455230713,
-0.07215890288352966,
0.20970258116722107,
0.1001744270324707,
-0.07097481191158295,
-0.058481425046920776,
0.012189768254756927,
-0.28954142332077026,
-0.042570557445287704,
0.00868317298591137,
0.03081957809627056,
-0.15082582831382751,
-0.08094040304422379,
0.08955603837966919,
-0.13170160353183746,
0.08779821544885635,
0.005464757326990366,
0.17962808907032013,
-0.34639421105384827,
-0.20622184872627258,
-0.003391699166968465,
0.010961752384901047,
0.09495629370212555,
0.1261935532093048,
-0.14131474494934082,
0.21790163218975067,
0.07179005444049835,
-0.005865451414138079,
-0.1726415604352951,
0.04053093120455742,
-0.15654388070106506,
-0.12240514904260635,
-0.005868398584425449,
0.11840652674436569,
-0.07961142063140869,
-0.012563741765916348,
0.056450653821229935,
-0.07816676050424576,
-0.5513336062431335,
-0.06212928891181946,
0.2207694798707962,
0.037482600659132004,
0.06466978788375854,
-0.01985018141567707,
0.07047418504953384,
0.12032260000705719,
0.04045604541897774,
-0.03319136053323746,
-0.01043647713959217,
-0.10859527438879013,
-0.19097717106342316,
0.02371763437986374,
-0.09889398515224457,
-0.23395653069019318,
0.05868009477853775,
0.12292136996984482,
0.2433185875415802,
-0.0014537944225594401,
-0.016367774456739426,
-0.08761309832334518,
-0.10247839242219925,
0.12688006460666656,
0.05718221142888069,
-0.30631303787231445,
0.12502290308475494,
-0.044518958777189255,
-0.1698978841304779,
-0.10606416314840317,
0.38840681314468384,
0.18034812808036804,
-0.024779319763183594,
0.19678013026714325,
0.04541425034403801,
-0.03807318955659866,
0.08848794549703598,
0.18146134912967682,
-0.13672050833702087,
-0.08544834703207016,
0.01791776902973652,
0.002071274910122156,
0.1439024806022644,
-0.06983926147222519,
0.0775216594338417,
0.10678225010633469,
0.2039228081703186,
0.23671327531337738,
-0.1364312320947647,
0.007683324161916971,
-0.032569922506809235,
0.00551336957141757,
0.18951056897640228,
0.20032811164855957,
0.06065892428159714,
0.22892984747886658,
-0.2224380373954773,
-0.038715217262506485,
-0.06645823270082474,
-0.12685973942279816,
0.04001577943563461,
0.0357864573597908,
-0.19635026156902313,
0.19390055537223816,
0.029156340286135674,
0.08647116273641586,
0.33698776364326477,
-0.07853832840919495,
0.12353405356407166,
0.05155225470662117,
0.18582813441753387,
0.24070920050144196,
-0.3600979447364807,
0.04462694376707077,
-0.01837153360247612,
-0.036262791603803635,
0.17515966296195984,
-0.024677656590938568,
-0.16112931072711945,
-0.12128621339797974,
0.08167456835508347,
-0.019319603219628334,
0.18390366435050964,
-0.0707087442278862,
-0.06168629974126816,
-0.3368704915046692,
0.06684156507253647,
-0.23875872790813446,
0.039665576070547104,
-0.06648886948823929,
0.05715465545654297,
-0.158024400472641,
-0.07209443300962448,
0.11119294911623001,
0.04096418619155884,
-0.07135248929262161,
-0.13309717178344727,
-0.052141401916742325,
-0.022079695016145706,
-0.09460601955652237,
0.2054927945137024,
-0.015544367022812366,
-0.012983624823391438,
0.03379461169242859,
0.055719949305057526,
-0.39538612961769104,
-0.04237176850438118,
0.2280806005001068,
0.18125708401203156,
0.09627392888069153,
0.17015650868415833,
0.17377547919750214,
0.17260131239891052,
-0.03622101619839668,
-0.015259376727044582,
0.0952739417552948,
-0.030808405950665474,
0.1463732272386551,
0.3061165511608124,
0.01515277847647667,
-0.03836219385266304,
0.14535826444625854,
-0.2524552643299103,
0.20713461935520172,
-0.13286615908145905,
0.08323457837104797,
-0.16555199027061462,
0.1038699746131897,
0.09703245013952255,
0.10677263885736465,
0.07511886209249496,
0.13194607198238373,
-0.2649393081665039,
0.042848750948905945,
-0.06226558983325958,
-0.23010288178920746,
0.3273080289363861,
0.23015019297599792,
0.12912462651729584,
0.04191143065690994,
-0.19700241088867188,
-0.016632255166769028,
-0.14595910906791687,
-0.15633536875247955,
-0.24220222234725952,
-0.11736013740301132,
-0.009871715679764748,
-0.20444200932979584,
0.02862321212887764,
0.3294970691204071,
0.17351941764354706,
0.037489812821149826,
0.025920191779732704,
-0.06561145186424255,
0.07513502240180969,
-0.07381940633058548,
0.012038514018058777,
-0.010250862687826157,
-0.22956493496894836,
-0.18918469548225403,
0.11292729526758194,
0.06655474007129669,
-0.08890965580940247,
0.13249078392982483,
0.17656894028186798,
-0.08555284142494202,
-0.20501591265201569,
0.1427222341299057,
0.25343555212020874,
-0.11369188874959946,
0.03139062598347664,
-0.04649406671524048,
0.10735584795475006,
-0.13619737327098846,
0.15060140192508698,
0.1536937654018402,
0.2458166778087616,
0.16036029160022736,
-0.220901757478714,
0.23089449107646942,
0.15777000784873962,
0.09590842574834824,
0.21567319333553314,
-0.042186468839645386,
0.2625558078289032,
0.05485736206173897,
0.35464775562286377,
0.2463657706975937,
-0.1549408733844757,
-0.029940135776996613,
-0.0978451520204544,
0.18639297783374786,
-0.1584620177745819,
0.09210511296987534,
0.1408127099275589,
-0.009204755537211895,
0.11222951114177704,
-0.2042320817708969,
0.16935235261917114,
0.13584524393081665,
-0.23186753690242767,
-0.22521914541721344,
-0.09178552031517029,
-0.12483149021863937,
-0.12446363270282745,
0.01660286635160446,
-0.14217545092105865,
0.18551822006702423,
0.08062488585710526,
-0.20273643732070923,
0.23542679846286774,
0.22709237039089203,
-0.08213706314563751,
-0.16645395755767822,
-0.06465538591146469,
0.023478219285607338,
0.1608574539422989,
-0.024826575070619583,
0.10980989038944244,
-0.2303910255432129,
-0.11339275538921356,
-0.004299805033951998,
0.24557243287563324,
-0.006050970871001482,
0.045739274471998215,
0.10036994516849518,
0.02568281628191471,
0.034671884030103683,
-0.21862073242664337,
0.08608368784189224,
0.0411214604973793,
0.020894857123494148,
-0.08178215473890305,
-0.06706232577562332,
0.1292753368616104,
-0.09399321675300598,
0.1638852208852768,
0.04058301821351051,
-0.022501427680253983,
0.41325730085372925,
0.01952272653579712,
-0.046967763453722,
-0.04670524224638939,
-0.1433083564043045,
0.19661705195903778,
-0.026582112535834312,
0.17007951438426971,
-0.003870563581585884,
0.11157950013875961,
0.1433149129152298,
0.035334549844264984,
0.06289125978946686,
-0.14887426793575287,
-0.021057188510894775,
0.30245620012283325,
0.14314699172973633,
0.14980387687683105,
0.039412062615156174,
-0.039457209408283234,
-0.2900962829589844,
-0.06667125970125198,
-0.12080483138561249,
0.21467193961143494,
0.2271268218755722,
0.3155409097671509,
-0.06502006202936172,
0.0036944136954844,
-0.15428370237350464,
-0.2273607850074768,
0.07140489667654037,
-0.0944882407784462,
-0.1819244772195816,
0.03398699685931206,
-0.10329606384038925,
-0.0033442736603319645,
-0.23975950479507446,
-0.029057657346129417,
-0.13301090896129608,
-0.175632506608963,
0.09258270263671875,
0.38097503781318665,
-0.13941019773483276,
0.0007625408470630646,
-0.03208131715655327,
0.14626316726207733,
0.0862584039568901,
0.1810462325811386,
0.0004934250027872622,
0.17468084394931793,
-0.099282406270504,
-0.11125019192695618,
-0.00878442544490099,
0.036911554634571075,
0.03562196344137192,
0.08699934184551239,
-0.03251161426305771,
-0.004484935663640499,
0.1709965169429779,
0.0040489863604307175,
-0.002854034537449479,
-0.11414819210767746,
0.10663856565952301,
0.005828435532748699,
-0.2617795169353485,
0.06249286234378815,
-0.027688371017575264,
0.08838764578104019,
-0.09196947515010834,
-0.08905819803476334,
-0.059577576816082,
-0.11488532274961472,
0.060215383768081665,
-0.051484715193510056,
0.05369646102190018,
-0.31298747658729553,
-0.1825893670320511,
-0.11923760920763016,
-0.12536035478115082,
0.06175491213798523,
-0.00041762375622056425,
-0.06934501975774765,
0.09283298999071121,
-0.14705497026443481,
0.1695784032344818,
-0.12833765149116516,
-0.03421761840581894,
-0.14343807101249695,
-0.19350764155387878,
0.1877099573612213,
0.17465128004550934,
-0.08411742746829987,
-0.05833907797932625,
-0.2703980505466461,
0.041501883417367935,
-0.015024840831756592,
-0.03951524943113327,
0.16031956672668457,
-0.11237713694572449,
-0.11490900814533234,
-0.1355566382408142,
0.25055792927742004,
0.14592891931533813,
0.1365588903427124,
-0.09584866464138031,
0.006550754886120558,
-0.04234638065099716,
-0.10474829375743866,
0.11138655990362167,
-0.023092223331332207,
-0.36293986439704895,
0.09653221070766449,
0.11674115806818008,
0.20918051898479462,
-0.05623294785618782,
0.4891933500766754,
-0.16959019005298615,
0.21724852919578552,
0.005293379537761211,
0.0808921754360199,
-0.22886088490486145,
0.096225805580616,
-0.02381688915193081,
-0.02964780479669571,
-0.24759802222251892,
-0.17970626056194305,
-0.19555418193340302,
0.18584060668945312,
0.20307022333145142,
-0.0937204360961914,
-0.07566171139478683,
-0.13051509857177734,
0.3356703817844391,
0.1878155618906021,
-0.14231182634830475,
0.014342565089464188,
0.019401591271162033,
-0.036761391907930374,
-0.010491853579878807,
-0.21913044154644012,
-0.036344122141599655,
-0.17740251123905182,
0.04789271950721741,
0.08198241889476776,
0.36817800998687744,
0.18903815746307373,
0.073015496134758,
-0.12763895094394684,
-0.07639139145612717,
-0.07332180440425873,
0.17771834135055542,
0.10369574278593063,
0.3583405613899231,
-0.14278164505958557,
-0.20231202244758606,
0.060754191130399704,
0.058810651302337646,
0.06941276788711548,
-0.07427137345075607,
0.04078437760472298,
-0.11619007587432861,
-0.15019582211971283,
-0.2146703004837036,
0.010832148604094982,
-0.029385752975940704,
0.2780968248844147,
-0.249765083193779,
0.10014501214027405,
0.03466027230024338,
-0.18735049664974213,
0.3492613434791565,
0.05761473625898361,
-0.21595363318920135,
0.007546254899352789,
-0.15826541185379028,
0.14980803430080414,
-0.013382108882069588,
0.19847337901592255,
0.04813066124916077,
0.03858567029237747,
-0.004117554519325495,
-0.09937729686498642,
-0.05279964208602905,
0.021665561944246292,
-0.03983534500002861,
0.003776493016630411,
0.3343680202960968,
-0.02738932892680168,
-0.047618743032217026,
0.1568574160337448,
0.10119296610355377,
-0.046944353729486465,
0.15970584750175476,
-0.13591355085372925,
0.12075762450695038,
0.07680931687355042,
0.00765170156955719,
-0.21115179359912872,
-0.16103613376617432,
0.1650305688381195,
0.0473298579454422,
-0.21448540687561035,
-0.031225048005580902,
0.2822970747947693,
0.22880055010318756,
0.10595901310443878,
-0.15998513996601105,
-0.03816453740000725,
0.06348404288291931,
-0.10931771248579025,
-0.09424090385437012,
0.04693954810500145,
0.1722051352262497,
0.06354497373104095,
0.1456562727689743,
0.006539653986692429,
-0.028596650809049606,
0.05534037947654724,
-0.11407478153705597,
-0.04812448099255562,
0.40841609239578247,
-0.07620032131671906,
0.03898220509290695,
-0.18365126848220825,
-0.023559486493468285,
-0.01867515593767166,
0.11053362488746643,
0.09932324290275574,
0.2661965489387512,
0.24276593327522278,
-0.05871225893497467,
-0.021470481529831886,
-0.07780233770608902,
-0.18998731672763824,
0.13491478562355042,
0.04558084160089493,
-0.10500498116016388,
-0.3223620057106018,
-0.24220885336399078,
0.1702820360660553,
0.1913810819387436,
-0.19634224474430084,
0.23605434596538544,
0.11166130751371384,
-0.031588416546583176,
0.11410412192344666,
0.22274349629878998,
-0.2823874354362488,
0.16135364770889282,
0.017076710239052773,
0.10596746951341629,
-0.019292598590254784,
0.20072545111179352,
-0.1302538961172104,
-0.1197744682431221,
-0.05274176597595215,
-0.11787977814674377,
0.039525531232357025,
0.24965772032737732,
0.16601411998271942,
-0.06010347977280617,
0.05575244128704071,
0.09839891642332077,
-0.05952205881476402,
-0.1811157464981079,
-0.12574703991413116,
0.09327902644872665,
-0.04197685047984123,
-0.14407384395599365,
0.05962635949254036,
-0.05457909777760506,
0.07940592616796494,
-0.24156203866004944,
-0.010043058544397354,
-0.05649209022521973
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. anemia, hypocomplementemia, and elevated ANA and anti-dsDNA antibodies).Butbul Aviel et al reported three individuals with the SLE/prolidase deficiency association:A boy age 4.5 years with a rash consistent with hypertrophic discoid lupus on biopsy, proteinuria and mild hematuria with a renal biopsy consistent with WHO Class IV lupus nephritis, low C3 and C4 levels, positive ANA (1:640; homogeneous pattern), anti ds-DNA, anti-RNP, anti-SM, anti Ro (SS-A) and anti La (SS-B)A girl age 16 years with macroscopic hematuria and proteinuria, with a renal biopsy demonstrating WHO Class IV lupus nephritis; she had low C3 and C4, as well as a highly positive ANA and positive anti ds-DNA titerA woman age 24 years with thrombocytopenia, a positive Coombs test, low C3 and C3 levels, and positive ANA and anti ds-DNA titersPositive ANA | [
-0.11868368834257126,
-0.026242904365062714,
0.09110374003648758,
-0.16512256860733032,
0.058008838444948196,
0.15449263155460358,
-0.38477784395217896,
-0.033630117774009705,
-0.030102619901299477,
-0.4677082896232605,
0.10485709458589554,
-0.08137720823287964,
0.1567317247390747,
-0.12981772422790527,
-0.13798534870147705,
0.11880667507648468,
-0.08213610202074051,
-0.007159700151532888,
0.015130641870200634,
-0.08317778259515762,
0.11443020403385162,
-0.25294429063796997,
0.2520878314971924,
0.3793465495109558,
0.2099558711051941,
-0.09421427547931671,
-0.04158944636583328,
0.11713846027851105,
0.05643553286790848,
0.32550933957099915,
0.1282406598329544,
-0.11495114117860794,
0.010600191541016102,
0.31740567088127136,
-0.03915375471115112,
-0.06877633929252625,
-0.3951864540576935,
-0.1235913336277008,
0.2983129322528839,
0.14579589664936066,
-0.21649472415447235,
0.03164297342300415,
0.1552015244960785,
0.18621422350406647,
-0.09062705188989639,
-0.23231418430805206,
-0.024875454604625702,
-0.10808221995830536,
-0.10281165689229965,
-0.03194916993379593,
0.24442383646965027,
0.03711063787341118,
-0.1770186722278595,
0.19942334294319153,
0.11996153742074966,
0.1635703295469284,
0.03619447350502014,
0.17779694497585297,
-0.05708301439881325,
0.029046105220913887,
-0.0671100839972496,
0.20558710396289825,
-0.020050466060638428,
-0.20482750236988068,
0.39029356837272644,
-0.27281659841537476,
0.1442200392484665,
0.2593615651130676,
-0.10198518633842468,
0.11447200179100037,
0.23361489176750183,
-0.14194399118423462,
0.2913992404937744,
-0.015919847413897514,
-0.02256958745419979,
0.1720593422651291,
0.19007040560245514,
-0.03593118116259575,
0.15488456189632416,
-0.15057697892189026,
0.04192933067679405,
0.12796400487422943,
-0.06760002672672272,
0.4315533936023712,
-0.12914270162582397,
0.003542855614796281,
0.1146986186504364,
0.10368724167346954,
-0.0322585366666317,
-0.18598303198814392,
0.03285878524184227,
-0.3076972961425781,
-0.05843675136566162,
-0.040007904171943665,
0.020651865750551224,
-0.0672667846083641,
-0.13038671016693115,
-0.20174004137516022,
0.023232003673911095,
0.06201810762286186,
0.10322979092597961,
0.07140083611011505,
-0.007769713178277016,
-0.19699156284332275,
-0.1849013864994049,
-0.3435458242893219,
-0.07780013233423233,
-0.17733310163021088,
-0.3073917031288147,
0.234684556722641,
0.3493385910987854,
0.04502327740192413,
-0.12185207009315491,
-0.05076681450009346,
-0.09289044141769409,
0.007767307106405497,
0.10691861063241959,
-0.17681612074375153,
-0.2350456714630127,
-0.13933350145816803,
-0.05881103128194809,
-0.23909881711006165,
0.0164820346981287,
-0.14876820147037506,
0.09146755188703537,
0.1221877783536911,
0.039643801748752594,
-0.0480099692940712,
0.16971971094608307,
-0.0010024802759289742,
0.03627564758062363,
0.05479834973812103,
-0.13189515471458435,
-0.3775695264339447,
-0.10195975750684738,
-0.2593934237957001,
0.0762641429901123,
-0.26882660388946533,
0.05320936441421509,
-0.015892786905169487,
-0.25222137570381165,
-0.08564287424087524,
0.3066914677619934,
0.23524616658687592,
-0.15246140956878662,
-0.26888203620910645,
0.3236396312713623,
-0.13133111596107483,
-0.12216830253601074,
0.1944016069173813,
0.24548906087875366,
-0.43778905272483826,
0.4465823769569397,
0.013048659078776836,
-0.3737051486968994,
0.04183219373226166,
0.011470779776573181,
0.06168993189930916,
-0.35061851143836975,
-0.17292216420173645,
0.33627599477767944,
0.1531069576740265,
0.015822529792785645,
-0.3471848964691162,
0.18870559334754944,
-0.22138464450836182,
0.09316286444664001,
-0.1506146639585495,
0.3966672420501709,
0.1885257214307785,
-0.10468247532844543,
-0.2232651710510254,
-0.015849614515900612,
0.021771686151623726,
0.4508163034915924,
0.05143518000841141,
-0.10470596700906754,
0.06842775642871857,
0.0056589883752167225,
-0.09964684396982193,
-0.09986870735883713,
-0.08908835053443909,
0.03546518459916115,
-0.22238801419734955,
0.01139033492654562,
-0.46013110876083374,
-0.10287526249885559,
0.022631490603089333,
-0.06943293660879135,
0.06698496639728546,
0.36713707447052,
0.02388526126742363,
-0.2253638654947281,
-0.382344514131546,
-0.006090950686484575,
-0.18767884373664856,
0.10190653055906296,
0.09668705612421036,
0.02985304594039917,
0.08478286862373352,
0.3203437328338623,
-0.16166217625141144,
-0.20677141845226288,
0.04549204558134079,
0.09755512326955795,
0.29748204350471497,
-0.06478903442621231,
-0.05470027029514313,
-0.17866013944149017,
0.3972313106060028,
0.14719247817993164,
0.04900725558400154,
-0.16252684593200684,
0.2889847457408905,
-0.06352823972702026,
-0.12656347453594208,
-0.22031907737255096,
-0.09393070638179779,
0.24830201268196106,
0.08466693758964539,
-0.04380529746413231,
-0.2117423564195633,
-0.04733259230852127,
-0.29157349467277527,
-0.07740575820207596,
0.018303213641047478,
0.10781443864107132,
-0.16780389845371246,
-0.12236227840185165,
0.10967103391885757,
-0.17044928669929504,
0.06502046436071396,
0.006736129522323608,
0.1671517938375473,
-0.40498948097229004,
-0.27790144085884094,
-0.02734794095158577,
0.050826072692871094,
0.030037689954042435,
0.18212345242500305,
-0.04863192141056061,
0.016944676637649536,
0.09435290843248367,
0.006700802594423294,
-0.0935739055275917,
0.005362126510590315,
-0.12055204063653946,
-0.22980666160583496,
-0.0680198147892952,
0.14785687625408173,
-0.02481991983950138,
-0.08913122862577438,
0.04454866051673889,
-0.07032855600118637,
-0.522899866104126,
-0.1411249339580536,
0.2374187707901001,
0.045014023780822754,
0.01968121901154518,
-0.08256559073925018,
0.18227684497833252,
0.21692222356796265,
0.08136752992868423,
-0.002906475681811571,
-0.025966543704271317,
-0.15741515159606934,
-0.18039679527282715,
-0.015148470178246498,
0.03546823561191559,
-0.2915059030056,
0.0899236872792244,
0.10840357840061188,
0.22184662520885468,
0.008265676908195019,
-0.03357541561126709,
-0.06403519213199615,
-0.16423450410366058,
0.14266890287399292,
-0.00032782196649350226,
-0.3950086832046509,
0.11609966307878494,
-0.14564906060695648,
-0.09134085476398468,
-0.11298432946205139,
0.36753979325294495,
0.10850834846496582,
0.04776344820857048,
0.33061084151268005,
0.04731723666191101,
-0.006177589297294617,
-0.012804760597646236,
0.1814030557870865,
-0.2472829818725586,
-0.09789632260799408,
-0.09915420413017273,
-0.011789267882704735,
0.04816658794879913,
-0.10132678598165512,
0.1859801560640335,
0.09545919299125671,
0.344903826713562,
0.16968925297260284,
-0.21000105142593384,
0.03415118157863617,
-0.04487137869000435,
0.09895610809326172,
0.15190140902996063,
0.1556457281112671,
-0.07578011602163315,
0.31767627596855164,
-0.15123243629932404,
-0.12224306166172028,
-0.20608514547348022,
-0.11439317464828491,
-0.008449872024357319,
0.03494897857308388,
-0.22443915903568268,
0.13384728133678436,
0.04240189120173454,
-0.04096771031618118,
0.3143901228904724,
-0.006078394595533609,
0.05855153873562813,
-0.012823862954974174,
0.16624458134174347,
0.2356305867433548,
-0.34022265672683716,
0.06150859594345093,
-0.14821137487888336,
-0.07148332893848419,
0.13347648084163666,
0.03776947781443596,
-0.08383648097515106,
-0.1335231065750122,
-0.03891190513968468,
-0.09850973635911942,
0.2512972056865692,
0.050917163491249084,
-0.03450726345181465,
-0.2780020236968994,
0.1422353833913803,
-0.26374658942222595,
0.08803622424602509,
-0.08080827444791794,
-0.004728086292743683,
-0.240802600979805,
0.017226390540599823,
0.08822677284479141,
0.0073128012008965015,
-0.10131306946277618,
-0.21947449445724487,
-0.1550348997116089,
-0.01858854480087757,
-0.01967267319560051,
0.11563534289598465,
0.024661878123879433,
0.0010768520878627896,
0.018090706318616867,
0.04852552339434624,
-0.5369552373886108,
0.04767118766903877,
0.13165204226970673,
0.1892666071653366,
0.08942851424217224,
0.1262282431125641,
0.2483779937028885,
0.1362999975681305,
0.035698987543582916,
0.08626148849725723,
0.17960600554943085,
-0.09559205174446106,
0.16734403371810913,
0.33393174409866333,
-0.03527982160449028,
0.12039872258901596,
0.15702398121356964,
-0.2673722207546234,
0.27782997488975525,
0.0014550866326317191,
0.22149476408958435,
-0.15939143300056458,
0.1584177017211914,
0.19545406103134155,
0.1303756684064865,
0.13334040343761444,
0.05690008029341698,
-0.1100001409649849,
-0.04550652578473091,
-0.09014273434877396,
-0.19052112102508545,
0.38056665658950806,
0.16547062993049622,
0.17458157241344452,
0.177582785487175,
-0.2551720440387726,
0.0322742722928524,
-0.18817025423049927,
-0.13788005709648132,
-0.25842222571372986,
-0.0291320588439703,
-0.14035126566886902,
-0.1492532193660736,
0.012580783106386662,
0.3430280089378357,
0.2610674798488617,
-0.024852987378835678,
0.006679465528577566,
-0.11633555591106415,
0.09671128541231155,
-0.016635190695524216,
0.017857704311609268,
0.006548167206346989,
-0.22605286538600922,
-0.2656184732913971,
0.08282047510147095,
0.13727425038814545,
-0.033586569130420685,
0.2402656078338623,
0.3070283532142639,
-0.15404264628887177,
-0.13648267090320587,
0.13455632328987122,
0.2842639982700348,
-0.020533407106995583,
0.08995024859905243,
-0.066098652780056,
0.17509493231773376,
-0.1580837219953537,
0.2766578793525696,
0.19345521926879883,
0.1686919629573822,
0.10418444126844406,
-0.10978171229362488,
0.1512015461921692,
0.19615168869495392,
-0.00019238331879023463,
0.2289811074733734,
-0.1894005984067917,
0.31730741262435913,
0.1285211443901062,
0.2766508460044861,
0.18844769895076752,
-0.21734176576137543,
-0.08372481167316437,
-0.06707172840833664,
0.21315652132034302,
-0.06817246973514557,
0.029420431703329086,
0.17015871405601501,
-0.14698244631290436,
0.10604900121688843,
-0.360556960105896,
0.10235019773244858,
0.19831976294517517,
-0.21049240231513977,
-0.38917097449302673,
-0.11289658397436142,
-0.08063061535358429,
-0.13893841207027435,
0.07175973802804947,
0.06065775454044342,
0.23559334874153137,
0.11405523866415024,
-0.3082123398780823,
0.20912852883338928,
0.3293314576148987,
-0.07189617305994034,
-0.20077501237392426,
0.026965539902448654,
0.00802353210747242,
0.15406398475170135,
-0.13727906346321106,
0.1667879968881607,
-0.31096184253692627,
-0.06326240301132202,
-0.08415812253952026,
0.34837648272514343,
-0.04372591897845268,
0.03853701800107956,
0.1149902418255806,
0.06545495241880417,
0.07318103313446045,
-0.3684746325016022,
0.11699140816926956,
0.0378553606569767,
0.054664451628923416,
-0.19512750208377838,
-0.14272519946098328,
0.1473943591117859,
-0.18379780650138855,
0.1928948611021042,
0.0475873164832592,
-0.01829381473362446,
0.5159354209899902,
0.02991241030395031,
-0.020738815888762474,
-0.08121000230312347,
-0.091567263007164,
0.2789458632469177,
-0.06744585931301117,
0.21381805837154388,
0.11483074724674225,
0.07141956686973572,
0.17349694669246674,
0.036271438002586365,
-0.021700777113437653,
-0.25206807255744934,
-0.0825028344988823,
0.36005550622940063,
0.0317244827747345,
0.21435269713401794,
-0.0328596793115139,
-0.049142420291900635,
-0.3187254071235657,
0.01750652678310871,
-0.25760436058044434,
0.3104299008846283,
0.28109610080718994,
0.3621165454387665,
-0.12052370607852936,
-0.017704952508211136,
-0.295478492975235,
-0.13551270961761475,
0.114237941801548,
-0.00046784328878857195,
-0.10013832151889801,
0.04459558054804802,
-0.14266705513000488,
0.06313781440258026,
-0.23530924320220947,
-0.07852374762296677,
-0.04937483370304108,
-0.19447658956050873,
0.03535931557416916,
0.3878915309906006,
-0.28537946939468384,
-0.06886342167854309,
-0.019312119111418724,
0.16424907743930817,
0.10698463767766953,
0.29933038353919983,
-0.11681371927261353,
0.1337646245956421,
-0.17184460163116455,
0.04781552776694298,
-0.07571157068014145,
0.03751179948449135,
0.0338192880153656,
0.1475248485803604,
-0.15202437341213226,
-0.11955524981021881,
0.12617512047290802,
-0.06503932923078537,
-0.02225089818239212,
-0.044374674558639526,
0.10803726315498352,
-0.019171973690390587,
-0.18103791773319244,
-0.0015687770210206509,
-0.09807191044092178,
0.09106261283159256,
-0.07128898054361343,
-0.10387160629034042,
0.06041337177157402,
-0.13034388422966003,
0.09595461934804916,
-0.05931427702307701,
0.04786483198404312,
-0.27485841512680054,
-0.2399756759405136,
-0.08855533599853516,
-0.13759170472621918,
0.0063009667210280895,
0.06670951098203659,
-0.03047795034945011,
0.02254115603864193,
-0.18744038045406342,
0.10519957542419434,
-0.20895545184612274,
-0.03263365104794502,
-0.2927006781101227,
-0.05666090548038483,
0.21966947615146637,
0.0900353491306305,
-0.16160635650157928,
-0.12319307774305344,
-0.17347821593284607,
0.08028560131788254,
-0.05964177846908569,
-0.12428801506757736,
0.2061764895915985,
-0.06480951607227325,
-0.16515561938285828,
-0.08760429173707962,
0.21957196295261383,
0.1333693265914917,
0.18125994503498077,
0.08125108480453491,
0.04071507230401039,
-0.05151546001434326,
-0.04666097089648247,
-0.037201888859272,
-0.0968320369720459,
-0.29923075437545776,
0.060562923550605774,
0.14656858146190643,
0.21798904240131378,
-0.11073797196149826,
0.47340768575668335,
-0.21262526512145996,
0.15359143912792206,
-0.014574253931641579,
0.051931966096162796,
-0.2122085690498352,
0.1469719260931015,
0.0005476752412505448,
-0.1246228739619255,
-0.15773244202136993,
-0.2331891655921936,
-0.21269108355045319,
0.1806672066450119,
0.21332605183124542,
-0.08756174147129059,
-0.11069000512361526,
-0.19620513916015625,
0.46710482239723206,
0.2241886705160141,
-0.049076374620199203,
0.18745699524879456,
0.04646195098757744,
-0.056977830827236176,
-0.006358042825013399,
-0.12132196128368378,
-0.16231727600097656,
-0.15402254462242126,
0.01971523091197014,
0.2843441367149353,
0.42040571570396423,
0.2504870891571045,
0.20296011865139008,
0.02023584395647049,
-0.09577029198408127,
0.001489690039306879,
0.15392519533634186,
-0.00879009161144495,
0.32820451259613037,
-0.11575433611869812,
-0.3230581283569336,
0.05331207811832428,
0.1641124188899994,
0.14857958257198334,
-0.032675858587026596,
0.032514359802007675,
-0.18491047620773315,
-0.14221614599227905,
-0.1254715770483017,
-0.0024570308160036802,
-0.1877746880054474,
0.31153568625450134,
-0.36188286542892456,
0.0697714313864708,
-0.01731884852051735,
-0.20676423609256744,
0.251223087310791,
0.06032106652855873,
-0.18597672879695892,
0.11052197217941284,
-0.11057194322347641,
0.10795040428638458,
-0.07684579491615295,
0.3235437273979187,
0.02140396274626255,
0.0730830729007721,
0.06917410343885422,
-0.16794125735759735,
-0.02117280662059784,
0.0042553008534014225,
-0.09190817922353745,
0.07110211253166199,
0.33859413862228394,
0.10690591484308243,
-0.043132513761520386,
0.31711649894714355,
0.15049302577972412,
-0.07720834761857986,
0.09057091176509857,
-0.11917835474014282,
0.11033812910318375,
0.026751527562737465,
0.006583156529814005,
-0.15597406029701233,
-0.062251295894384384,
0.18086086213588715,
-0.05432317033410072,
-0.21082504093647003,
-0.03417017310857773,
0.20809903740882874,
0.2329534888267517,
0.12482625246047974,
-0.10951048135757446,
0.10461471974849701,
-0.05688946694135666,
-0.10272786021232605,
-0.15648992359638214,
0.12743498384952545,
0.36236998438835144,
-0.06283940374851227,
0.16583240032196045,
-0.026924580335617065,
0.013830059207975864,
0.2510247528553009,
-0.08341740816831589,
-0.03427461162209511,
0.41553303599357605,
0.061716385185718536,
0.07101699709892273,
-0.19886572659015656,
0.03144090250134468,
0.11478076875209808,
0.0347796268761158,
0.10873342305421829,
0.25427165627479553,
0.2805454134941101,
-0.11674930900335312,
0.03935021534562111,
-0.07545111328363419,
-0.19154031574726105,
0.1304820030927658,
0.10639947652816772,
-0.14963111281394958,
-0.2764080762863159,
-0.31150954961776733,
0.27311456203460693,
0.21124111115932465,
-0.19538192451000214,
0.1919364035129547,
0.11354407668113708,
-0.01606561988592148,
0.10639272630214691,
0.19513027369976044,
-0.307529091835022,
0.11540410667657852,
-0.004252606071531773,
0.12926171720027924,
-0.06295181065797806,
0.04643557220697403,
-0.10590896755456924,
-0.21657808125019073,
-0.06468147784471512,
-0.0894419327378273,
-0.012669626623392105,
0.2906990945339203,
0.20750682055950165,
-0.09106794744729996,
0.032279014587402344,
0.1288379430770874,
-0.08948642015457153,
-0.15713214874267578,
-0.18684829771518707,
0.11561549454927444,
-0.034920673817396164,
-0.17311401665210724,
0.14447994530200958,
0.009253079071640968,
0.1339678019285202,
-0.3214609920978546,
-0.06821762770414352,
-0.07145699858665466
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. -RNP, anti-SM, anti Ro (SS-A) and anti La (SS-B)A girl age 16 years with macroscopic hematuria and proteinuria, with a renal biopsy demonstrating WHO Class IV lupus nephritis; she had low C3 and C4, as well as a highly positive ANA and positive anti ds-DNA titerA woman age 24 years with thrombocytopenia, a positive Coombs test, low C3 and C3 levels, and positive ANA and anti ds-DNA titersPositive ANA, anti-dsDNA, anti-ENA (anti-Ro), anti-Sm and anti-chromatin have been found in individuals with prolidase deficiency even in the absence of clinical findings of SLE .Bone manifestations. Among 12 affected individuals reported by Besio et al , short stature was described in seven, osteopenia in six, and genu valgum in four.Other bone findings include spina bifida of C3 and 13 thoracic vertebrae ; fusion of C2 and C3 | [
-0.05421091243624687,
-0.07087501883506775,
-0.024075914174318314,
-0.07571439445018768,
0.2797558605670929,
0.1032770574092865,
-0.15864498913288116,
-0.038577429950237274,
-0.16584965586662292,
-0.34694787859916687,
0.07759352028369904,
0.09560215473175049,
0.06724419444799423,
0.16926886141300201,
-0.12455929815769196,
0.2321428656578064,
-0.06729527562856674,
-0.05192084237933159,
-0.06724640727043152,
-0.06418497115373611,
0.19931857287883759,
-0.1797594130039215,
0.24231509864330292,
0.23191899061203003,
0.07640232145786285,
-0.17098712921142578,
-0.08588863909244537,
0.1166084036231041,
-0.009096656925976276,
0.2998202443122864,
0.13935832679271698,
-0.20564395189285278,
0.002968680579215288,
0.09475065767765045,
0.1198391541838646,
-0.07199151813983917,
-0.2893257439136505,
-0.09200534224510193,
0.22329571843147278,
0.06290864199399948,
-0.25503668189048767,
-0.009821233339607716,
0.19177104532718658,
0.22627303004264832,
-0.008632063865661621,
-0.18280144035816193,
0.06835640221834183,
-0.08344787359237671,
-0.15412718057632446,
0.06671803444623947,
0.25711125135421753,
-0.060139283537864685,
-0.20493614673614502,
0.27122724056243896,
0.2022840976715088,
0.009830589406192303,
-0.13533590734004974,
0.1432248204946518,
0.11482022702693939,
0.16804559528827667,
0.018783142790198326,
-0.017017491161823273,
-0.15629221498966217,
-0.2692543864250183,
0.20749416947364807,
-0.23853327333927155,
0.10255984216928482,
0.12075550854206085,
-0.010682621039450169,
0.07790929079055786,
0.3748095631599426,
-0.1047036275267601,
0.28540563583374023,
-0.07729649543762207,
-0.2018449753522873,
0.1903073787689209,
0.034875087440013885,
-0.19269990921020508,
0.07088423520326614,
-0.2071135938167572,
0.0057414136826992035,
0.07455247640609741,
-0.11037225276231766,
0.11973491311073303,
-0.0812099277973175,
0.17461447417736053,
0.024888383224606514,
0.09705060720443726,
-0.06720606237649918,
-0.12872058153152466,
0.04469949007034302,
-0.14372526109218597,
-0.012896350584924221,
-0.11867819726467133,
0.047551631927490234,
0.037681058049201965,
-0.055359143763780594,
-0.03316483274102211,
-0.036166638135910034,
0.0022169561125338078,
-0.05742723494768143,
0.1906501054763794,
0.010456476360559464,
-0.07171653211116791,
-0.2408694326877594,
-0.26836106181144714,
0.017154209315776825,
0.033377427607774734,
-0.16341282427310944,
0.029591450467705727,
0.2228124439716339,
0.049256838858127594,
-0.0243486650288105,
-0.04049566015601158,
-0.0845973864197731,
0.019504887983202934,
0.11885086447000504,
0.05237991362810135,
-0.17510832846164703,
-0.16200275719165802,
0.06587599962949753,
-0.21567149460315704,
-0.05515095219016075,
0.008210370317101479,
0.2699202299118042,
0.1649363934993744,
-0.013789348304271698,
0.053876057267189026,
0.23216864466667175,
-0.03194728493690491,
0.16448520123958588,
0.01982175000011921,
-0.23473981022834778,
-0.5369360446929932,
0.01265253871679306,
-0.31091201305389404,
-0.05407415330410004,
-0.3199544847011566,
-0.10161539167165756,
0.007094671484082937,
-0.10270944982767105,
0.031156735494732857,
0.14786569774150848,
0.3002156615257263,
0.04485689103603363,
-0.24659450352191925,
0.33351513743400574,
-0.006112972274422646,
0.023646457120776176,
0.11304618418216705,
0.18142637610435486,
-0.29793626070022583,
0.38119977712631226,
-0.06880249083042145,
-0.18401476740837097,
-0.0022572677116841078,
-0.019057538360357285,
0.12449386715888977,
-0.2629658877849579,
0.06585710495710373,
0.2023673951625824,
-0.014883678406476974,
0.1885296255350113,
-0.27162525057792664,
0.048558309674263,
-0.08988063037395477,
0.05439353361725807,
-0.015133500099182129,
0.13426382839679718,
0.08362792432308197,
-0.17106197774410248,
-0.10414889454841614,
-0.004901503678411245,
-0.06010882928967476,
0.34149420261383057,
0.03447391837835312,
-0.05433094501495361,
0.09418155252933502,
-0.04179610684514046,
-0.06154239922761917,
-0.10580248385667801,
-0.11498508602380753,
-0.10060999542474747,
-0.267084002494812,
0.01094748079776764,
-0.400406152009964,
0.0007011282723397017,
-0.062122296541929245,
0.07033692300319672,
0.0006033236859366298,
0.24721141159534454,
-0.063909150660038,
-0.1559886634349823,
-0.2941884994506836,
0.04809058457612991,
-0.19099922478199005,
0.08730050176382065,
0.035301025956869125,
0.02118092216551304,
0.05841870233416557,
0.29297301173210144,
-0.19848711788654327,
-0.07427117973566055,
-0.10173246264457703,
0.04203445836901665,
0.1195298507809639,
-0.039146699011325836,
-0.021334722638130188,
-0.09107603877782822,
0.24730311334133148,
0.07683317363262177,
0.06919331848621368,
-0.13582494854927063,
0.08031551539897919,
0.01306319609284401,
-0.10460041463375092,
-0.15471233427524567,
-0.025303641334176064,
0.07606116682291031,
0.08193221688270569,
0.036999400705099106,
-0.21880269050598145,
0.00958869606256485,
-0.2741518020629883,
-0.18752862513065338,
-0.1127253919839859,
-0.07404074817895889,
-0.08048932254314423,
-0.04168539121747017,
0.0163357462733984,
-0.3183310627937317,
0.004846334457397461,
0.07080226391553879,
0.24716027081012726,
-0.11113667488098145,
-0.26731428503990173,
-0.11692683398723602,
0.10908982902765274,
0.08581287413835526,
0.11814160645008087,
-0.21690919995307922,
-0.08374837040901184,
0.04461974278092384,
-0.01386234536767006,
-0.16983434557914734,
0.18616843223571777,
-0.2064431607723236,
-0.1119888499379158,
-0.13217799365520477,
0.1794864386320114,
-0.18959148228168488,
-0.04042273387312889,
0.06196711212396622,
-0.1397925168275833,
-0.43595167994499207,
-0.12553070485591888,
0.3759124279022217,
0.020943155512213707,
0.04901888221502304,
0.01368650607764721,
0.28039810061454773,
0.16491755843162537,
0.09702353924512863,
-0.031163230538368225,
-0.023459026589989662,
-0.20308108627796173,
-0.15776026248931885,
-0.030426060780882835,
-0.025599457323551178,
-0.2545756697654724,
0.04761049896478653,
0.09690497070550919,
0.32837826013565063,
0.13840888440608978,
0.016837621107697487,
-0.09261766076087952,
-0.20018599927425385,
0.014001154340803623,
0.06565137207508087,
-0.1972033530473709,
0.11605021357536316,
-0.038321156054735184,
-0.12910887598991394,
-0.026276150718331337,
0.3471008539199829,
0.13642820715904236,
0.07572250813245773,
0.13757796585559845,
0.008598163723945618,
-0.054102566093206406,
0.0893186554312706,
0.1381615251302719,
-0.19602157175540924,
-0.13438931107521057,
-0.07341262698173523,
0.011298217810690403,
-0.08685940504074097,
-0.16935017704963684,
0.07653629779815674,
0.03409631550312042,
0.27944493293762207,
0.17541003227233887,
0.03186279535293579,
-0.023471947759389877,
-0.019556697458028793,
0.018337927758693695,
0.044763244688510895,
0.20581698417663574,
-0.1567288339138031,
0.19729453325271606,
-0.1959986686706543,
-0.05601111054420471,
-0.022435173392295837,
-0.004172570072114468,
-0.06802991032600403,
0.017590371891856194,
-0.3037007749080658,
0.18107803165912628,
0.1484842747449875,
0.055029209703207016,
0.24991950392723083,
-0.21993497014045715,
0.051155801862478256,
0.094570592045784,
0.07352576404809952,
0.19077850878238678,
-0.31224241852760315,
0.0016673235222697258,
-0.31431373953819275,
-0.12254080921411514,
0.16678856313228607,
0.03816482052206993,
-0.21193163096904755,
-0.028941437602043152,
0.03917328640818596,
0.10551201552152634,
0.22422166168689728,
0.09074533730745316,
0.0049233525060117245,
-0.1604626625776291,
0.19475677609443665,
-0.08258620649576187,
0.0741056576371193,
-0.11148921400308609,
0.10956205427646637,
-0.11609441041946411,
0.0080927899107337,
0.2512345612049103,
-0.056424740701913834,
-0.10796268284320831,
-0.15912854671478271,
-0.23920980095863342,
0.06757193058729172,
-0.07189970463514328,
0.13515178859233856,
0.053545791655778885,
-0.06444667279720306,
0.04055460914969444,
0.23306162655353546,
-0.28158876299858093,
-0.1254229098558426,
0.184966579079628,
0.1383620798587799,
-0.14018277823925018,
0.2488023191690445,
0.033816464245319366,
0.01629786752164364,
0.10058705508708954,
0.00008684964996064082,
0.23368705809116364,
0.017514044418931007,
0.003932203631848097,
0.23168523609638214,
0.028952786698937416,
0.05921211093664169,
0.006949851755052805,
-0.21684090793132782,
0.2371186465024948,
-0.1498359739780426,
0.02223505824804306,
-0.2258296012878418,
0.08581792563199997,
0.13662520051002502,
0.17626917362213135,
0.08322229236364365,
0.2210981398820877,
-0.05943218618631363,
-0.0515255481004715,
-0.003413130296394229,
-0.44248032569885254,
0.23042260110378265,
0.22905871272087097,
0.15119194984436035,
0.16300806403160095,
-0.2064928263425827,
-0.027234304696321487,
-0.0859067514538765,
-0.1744314730167389,
-0.2541027367115021,
0.07998540997505188,
-0.060109298676252365,
-0.023058827966451645,
0.07729718834161758,
0.22476959228515625,
0.2972005307674408,
0.07436246424913406,
-0.09404047578573227,
-0.007378613576292992,
0.09731347858905792,
-0.023109927773475647,
-0.026159441098570824,
-0.09673427790403366,
-0.1624690294265747,
-0.14746315777301788,
0.08909724652767181,
0.03724055737257004,
0.02082042209804058,
0.07247824966907501,
0.3249218761920929,
-0.1983836442232132,
-0.1974969208240509,
0.1507093757390976,
0.2140359729528427,
-0.02810083143413067,
-0.09670733660459518,
-0.08960509300231934,
0.17554669082164764,
-0.1379137486219406,
0.30640798807144165,
0.21154166758060455,
0.09112139791250229,
0.17537397146224976,
-0.08433926105499268,
0.18713581562042236,
0.2219812572002411,
0.009077668190002441,
-0.041938792914152145,
-0.033446986228227615,
0.3160385489463806,
-0.03105395846068859,
0.1546148955821991,
0.012216071598231792,
-0.2136552631855011,
-0.02876313403248787,
-0.026638641953468323,
0.0422162190079689,
-0.055285148322582245,
-0.01739737018942833,
0.14187192916870117,
-0.08445095270872116,
0.036095887422561646,
-0.22012266516685486,
0.07208065688610077,
-0.006686850916594267,
-0.13609819114208221,
-0.20437705516815186,
-0.07054460048675537,
-0.0790814459323883,
-0.05446767434477806,
0.06460296362638474,
-0.0861959233880043,
0.07452099770307541,
0.14492611587047577,
-0.05137583240866661,
0.0423339381814003,
0.4305899441242218,
-0.060290396213531494,
-0.07529066503047943,
0.0580960214138031,
0.08333244919776917,
0.02659779042005539,
-0.019229982048273087,
0.04996594041585922,
-0.19513165950775146,
-0.1477421075105667,
-0.08484308421611786,
0.21511229872703552,
-0.0340048223733902,
-0.09044094383716583,
0.08843577653169632,
0.15440799295902252,
0.0890350267291069,
-0.2156325727701187,
0.04152671992778778,
0.1016974076628685,
-0.012492713518440723,
-0.06898828595876694,
0.012266699224710464,
0.23704589903354645,
-0.07368767261505127,
0.2781614661216736,
0.09456906467676163,
0.02658357284963131,
0.32595112919807434,
-0.032352086156606674,
0.014911845326423645,
-0.06501148641109467,
-0.22536522150039673,
0.11705309897661209,
-0.047298792749643326,
0.07959567755460739,
-0.0003992950660176575,
0.06860839575529099,
0.16479574143886566,
0.08404994755983353,
-0.04809898883104324,
-0.10685130208730698,
-0.1836773008108139,
0.1107272133231163,
0.05240749195218086,
0.14581544697284698,
-0.03289516270160675,
-0.080137237906456,
-0.2609899342060089,
-0.07577693462371826,
-0.25962889194488525,
0.2500675618648529,
0.15113598108291626,
0.1803043782711029,
-0.1363963633775711,
0.1498379409313202,
-0.3213568329811096,
-0.15814261138439178,
0.023129358887672424,
-0.06262689083814621,
-0.16202418506145477,
0.13188821077346802,
-0.039040707051754,
-0.06150443106889725,
-0.223439022898674,
0.04992649704217911,
-0.1979251652956009,
-0.16293464601039886,
0.12408193200826645,
0.2390350103378296,
-0.36832505464553833,
-0.02960985340178013,
-0.019744636490941048,
0.0792267844080925,
0.05586054548621178,
0.19068235158920288,
0.02022334188222885,
0.23537451028823853,
0.017220064997673035,
-0.12381546199321747,
0.049017615616321564,
0.26884812116622925,
-0.04704679548740387,
0.18566526472568512,
-0.02833024226129055,
-0.23035475611686707,
0.09219400584697723,
-0.10803085565567017,
0.03157476708292961,
0.08195071667432785,
-0.0015704126562923193,
-0.005466914735734463,
-0.21711640059947968,
-0.0626063197851181,
0.08067367225885391,
0.13016776740550995,
-0.09306206554174423,
-0.21060003340244293,
-0.10226920992136002,
-0.1907486617565155,
0.18622387945652008,
0.07652485370635986,
0.1145239993929863,
-0.2289351373910904,
-0.33025267720222473,
-0.20934531092643738,
-0.06074950844049454,
-0.12478466331958771,
-0.0028435057029128075,
-0.04137367382645607,
0.08352428674697876,
-0.14245329797267914,
-0.06625975668430328,
-0.004150882363319397,
0.053338222205638885,
-0.18022821843624115,
-0.07279078662395477,
0.18296726047992706,
0.1705200970172882,
0.05211587995290756,
0.057731930166482925,
-0.09778516739606857,
0.05020134523510933,
-0.0650530532002449,
-0.14287544786930084,
0.1602431684732437,
-0.10364626348018646,
-0.08328746259212494,
-0.17070475220680237,
0.11299203336238861,
0.07504944503307343,
0.06406731903553009,
0.03648899123072624,
-0.13311371207237244,
-0.058532897382974625,
0.09143108874559402,
0.06296496838331223,
-0.10544643551111221,
-0.24173784255981445,
0.07131648808717728,
0.17797677218914032,
0.1331440806388855,
-0.18104994297027588,
0.33908653259277344,
-0.06981828808784485,
-0.08102890104055405,
-0.03666423633694649,
0.14057572185993195,
-0.02996106632053852,
0.05063696578145027,
-0.05626324191689491,
-0.0840747207403183,
-0.07942525297403336,
-0.18974493443965912,
-0.14749053120613098,
0.16677024960517883,
0.08540705591440201,
-0.006504707038402557,
-0.10255017876625061,
-0.16963668167591095,
0.35653600096702576,
0.16909398138523102,
0.025589821860194206,
0.19814707338809967,
-0.06820089370012283,
-0.2316976636648178,
-0.06784344464540482,
-0.1589595526456833,
-0.20533771812915802,
-0.04624214395880699,
0.08937139809131622,
0.04711078479886055,
0.38223594427108765,
0.09451577812433243,
-0.0126320980489254,
0.12016965448856354,
0.011948609724640846,
0.14581258594989777,
0.2215571254491806,
-0.05111095681786537,
0.25860345363616943,
-0.13033916056156158,
-0.1608784943819046,
-0.09093708544969559,
0.1443764865398407,
0.2178182303905487,
0.043032094836235046,
0.16124945878982544,
-0.18453684449195862,
-0.24012701213359833,
-0.051679130643606186,
-0.0031079957261681557,
-0.14160698652267456,
0.3779621422290802,
-0.4317495822906494,
0.1045767217874527,
-0.2181130200624466,
-0.06677260249853134,
0.21681353449821472,
0.014686178416013718,
-0.23147110641002655,
0.07599425315856934,
-0.058397091925144196,
0.09324994683265686,
-0.20609812438488007,
0.15311653912067413,
0.050048358738422394,
0.08994202315807343,
-0.11888429522514343,
-0.08083990961313248,
-0.22177205979824066,
-0.03501121327280998,
-0.10614071041345596,
0.09369702637195587,
0.29644685983657837,
0.08455472439527512,
-0.22294272482395172,
0.20720402896404266,
-0.061463113874197006,
0.02233712188899517,
0.18488004803657532,
-0.06764055788516998,
0.008277639746665955,
0.03714415058493614,
0.024477439001202583,
-0.08329560607671738,
-0.010318207554519176,
0.22343216836452484,
0.06554574519395828,
-0.21928605437278748,
-0.10570564866065979,
0.23350313305854797,
0.14996075630187988,
-0.04267853870987892,
-0.12727998197078705,
0.03584727644920349,
0.024118544533848763,
-0.16246086359024048,
-0.12377563863992691,
-0.043599311262369156,
0.2634798586368561,
-0.043677132576704025,
0.02342238277196884,
-0.026799073442816734,
-0.03841983899474144,
-0.007974458858370781,
-0.004418490920215845,
-0.06836328655481339,
0.46584686636924744,
0.07719793915748596,
0.10450059175491333,
-0.25184324383735657,
-0.10912290215492249,
0.12325162440538406,
-0.14505091309547424,
0.05809350311756134,
0.014683771878480911,
0.11304843425750732,
0.0564248152077198,
-0.0014155105454847217,
0.038471486419439316,
-0.11869411170482635,
0.14570730924606323,
0.17942553758621216,
-0.033679261803627014,
-0.15423214435577393,
-0.1986120343208313,
0.09976674616336823,
0.20129549503326416,
-0.01845075935125351,
0.09658882766962051,
0.0026717723812907934,
-0.05198969319462776,
0.0075997719541192055,
0.2869942784309387,
-0.2792210578918457,
0.20530393719673157,
0.12855783104896545,
0.03944838419556618,
0.02042505145072937,
0.05836982652544975,
-0.06109147518873215,
-0.07869028300046921,
0.026262830942869186,
-0.04240135848522186,
0.07828909158706665,
0.22709928452968597,
0.3094358444213867,
-0.14130985736846924,
0.05880453810095787,
0.094707190990448,
-0.08513779193162918,
-0.2829720675945282,
-0.10103795677423477,
0.023997342213988304,
-0.087649405002594,
-0.124681256711483,
0.08313383907079697,
0.06893893331289291,
0.14256732165813446,
-0.10417348146438599,
0.008094264194369316,
-0.05540746450424194
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. DNA titersPositive ANA, anti-dsDNA, anti-ENA (anti-Ro), anti-Sm and anti-chromatin have been found in individuals with prolidase deficiency even in the absence of clinical findings of SLE .Bone manifestations. Among 12 affected individuals reported by Besio et al , short stature was described in seven, osteopenia in six, and genu valgum in four.Other bone findings include spina bifida of C3 and 13 thoracic vertebrae ; fusion of C2 and C3 ; and delayed bone age .Digital clubbing, in the presence and in the absence of pulmonary abnormalities, has also been reported .Other manifestationsJoint laxity , including hip dislocation Protuberant abdomen in five of the first 17 cases reported Obesity Optic and chorioretinal atrophy , keratitis and pathologic myopia Erosive cystitis (one individual) Dental dysplasia Autoimmune adrenal failure (one individual) Prognosis. The severity of prolidase deficiency is quite variable: in some individuals skin ulcerations lead to amputation | [
-0.07949692010879517,
0.08411753922700882,
0.039322178810834885,
-0.1365196704864502,
0.22404056787490845,
0.05159635841846466,
0.0084907878190279,
-0.14702396094799042,
-0.13119971752166748,
-0.24136121571063995,
0.10847985744476318,
0.17420855164527893,
0.14263394474983215,
0.23726606369018555,
-0.05006241425871849,
0.16863536834716797,
0.0030720343347638845,
0.00595885468646884,
-0.1929939240217209,
-0.03711966797709465,
0.11861295998096466,
-0.09636291861534119,
0.29846277832984924,
0.21695004403591156,
0.15721771121025085,
-0.09561975300312042,
-0.08276428282260895,
0.013970459811389446,
0.02360859327018261,
0.2772422134876251,
0.1534671038389206,
-0.18921150267124176,
-0.10279206931591034,
-0.08522344380617142,
0.24933010339736938,
-0.06968909502029419,
-0.0898498147726059,
-0.005846779327839613,
0.20828400552272797,
-0.02230631187558174,
-0.22992312908172607,
0.04952606186270714,
0.11323787271976471,
0.097388856112957,
0.02146080695092678,
-0.09343267232179642,
0.10256107896566391,
-0.007653119973838329,
-0.16363054513931274,
0.1527247279882431,
0.21807074546813965,
-0.03188609331846237,
-0.17699404060840607,
0.11197023838758469,
0.248875692486763,
0.011306517757475376,
-0.172882542014122,
0.11812958121299744,
0.0669708102941513,
0.25513380765914917,
0.09009427577257156,
-0.04791630432009697,
-0.15867821872234344,
-0.31447675824165344,
0.11867325752973557,
-0.15911659598350525,
-0.014037822373211384,
0.03843763843178749,
-0.041924238204956055,
0.10820389539003372,
0.4593016803264618,
-0.018615737557411194,
0.15519961714744568,
-0.08705661445856094,
-0.2404026985168457,
-0.013642959296703339,
0.005017396528273821,
-0.16576826572418213,
0.08145173639059067,
-0.21720920503139496,
-0.11698464304208755,
0.0734429731965065,
-0.12256190180778503,
-0.02737497352063656,
0.0010875690495595336,
0.3041919469833374,
0.06822001188993454,
0.12790706753730774,
-0.04596225172281265,
-0.020950963720679283,
0.12438822537660599,
-0.21680845320224762,
0.07194362580776215,
-0.17950871586799622,
-0.07999532669782639,
0.08633853495121002,
-0.06727831810712814,
0.07833728194236755,
0.010763796046376228,
0.1083431988954544,
0.044652022421360016,
0.014034709893167019,
0.13998405635356903,
0.04717811197042465,
-0.10022946447134018,
-0.2294735610485077,
-0.07821846008300781,
0.16116395592689514,
-0.1647767424583435,
0.0569080151617527,
0.15172579884529114,
0.045984845608472824,
-0.10523448884487152,
-0.05840935930609703,
0.017702873796224594,
0.0861341655254364,
0.1906006932258606,
0.127329021692276,
-0.029102342203259468,
-0.23058556020259857,
0.024758610874414444,
0.019422201439738274,
-0.06449482589960098,
0.02634044736623764,
0.413914293050766,
0.1833658218383789,
0.00924647320061922,
0.09177501499652863,
0.3006993532180786,
-0.10953229665756226,
0.09750895202159882,
-0.034897442907094955,
-0.19209836423397064,
-0.49004215002059937,
-0.018559277057647705,
-0.2442329227924347,
-0.31129008531570435,
-0.3764861226081848,
-0.10681558400392532,
-0.003204135224223137,
-0.008150393143296242,
-0.06810793280601501,
0.09800148010253906,
0.34041479229927063,
0.040246084332466125,
-0.12840181589126587,
0.42846643924713135,
0.09277257323265076,
0.05521184951066971,
0.11202588677406311,
-0.020894359797239304,
-0.12860122323036194,
0.38179346919059753,
-0.006606284528970718,
-0.04040277749300003,
0.03138890489935875,
-0.030614590272307396,
0.12057474255561829,
-0.2954830229282379,
0.1125187873840332,
0.16339412331581116,
-0.11222371459007263,
0.1993504911661148,
-0.2237377166748047,
0.02672046609222889,
0.004696231335401535,
-0.00910238828510046,
-0.09391972422599792,
-0.05411774292588234,
0.04201632738113403,
-0.09583926200866699,
0.0033036512322723866,
-0.10937454551458359,
0.02412068098783493,
0.16610801219940186,
0.14757858216762543,
-0.003941134549677372,
-0.041297104209661484,
0.048665519803762436,
-0.006244197953492403,
-0.03240204229950905,
-0.06439138948917389,
-0.18767142295837402,
-0.21830196678638458,
-0.01603030413389206,
-0.3218952715396881,
0.07148284465074539,
-0.08022057265043259,
0.1155952662229538,
0.15767571330070496,
-0.010623615235090256,
-0.06607890874147415,
-0.07774031907320023,
-0.16580460965633392,
0.09081882238388062,
-0.17619208991527557,
0.10047592222690582,
0.04403695836663246,
-0.05530280992388725,
0.10768768191337585,
0.22982601821422577,
-0.25945356488227844,
0.08933445066213608,
-0.10213347524404526,
-0.18173561990261078,
0.016903895884752274,
-0.07094947248697281,
0.11795523762702942,
-0.11817213892936707,
0.22408771514892578,
0.025740884244441986,
0.2090444713830948,
-0.10786810517311096,
-0.03618983179330826,
-0.0744008794426918,
-0.007194989360868931,
-0.13902713358402252,
-0.0058050937950611115,
-0.012835501693189144,
0.09557750076055527,
0.04511208459734917,
-0.10720723122358322,
0.05722391605377197,
-0.21917161345481873,
-0.18583939969539642,
0.06381799280643463,
-0.10886228084564209,
0.062278538942337036,
-0.05132647603750229,
0.09637577831745148,
-0.21823269128799438,
-0.02579626441001892,
0.1345520168542862,
0.14001594483852386,
-0.07169527560472488,
-0.16870401799678802,
-0.06991622596979141,
0.16359592974185944,
0.09789909422397614,
0.09072050452232361,
-0.26688656210899353,
-0.034320902079343796,
0.14352139830589294,
0.00620766868814826,
-0.13401448726654053,
0.1650964468717575,
-0.12320715188980103,
0.08300435543060303,
-0.1070016399025917,
0.1607779860496521,
-0.1423969268798828,
0.04995032027363777,
0.04336346685886383,
-0.09943965822458267,
-0.37089061737060547,
0.13337378203868866,
0.28655296564102173,
0.007015411276370287,
0.09029389917850494,
0.03171657398343086,
0.18649287521839142,
0.14149807393550873,
0.1350351721048355,
-0.07412659376859665,
-0.028797587379813194,
-0.10535112768411636,
-0.24392765760421753,
0.00510910339653492,
0.05114887282252312,
-0.16451002657413483,
0.044863540679216385,
0.028549430891871452,
0.2867315709590912,
0.2177772969007492,
-0.13086506724357605,
-0.055760398507118225,
-0.3443813621997833,
0.08340009301900864,
0.19153490662574768,
-0.15232397615909576,
0.08553874492645264,
-0.011847604997456074,
-0.2054348886013031,
0.03440462797880173,
0.21613483130931854,
0.008411895483732224,
0.1325184553861618,
0.053775399923324585,
-0.003927748184651136,
-0.047451168298721313,
0.04301776364445686,
0.11817391216754913,
-0.16908524930477142,
-0.09288530051708221,
-0.1024685949087143,
0.1115216463804245,
-0.11329624056816101,
-0.11273070424795151,
-0.022067377343773842,
0.03847946599125862,
0.28811681270599365,
0.16306060552597046,
0.04589352011680603,
-0.031674664467573166,
-0.03012971207499504,
0.10272704809904099,
-0.026799775660037994,
0.15389706194400787,
-0.2530975937843323,
0.07796473056077957,
-0.2541605532169342,
0.01283049676567316,
0.025300800800323486,
0.02895691804587841,
-0.014398019760847092,
-0.04606984555721283,
-0.3350773751735687,
0.17998462915420532,
0.19729666411876678,
0.041164107620716095,
0.293935626745224,
-0.22908489406108856,
0.09666381031274796,
0.3748174011707306,
0.04795495420694351,
0.040647171437740326,
-0.10434170812368393,
0.033565305173397064,
-0.2959360182285309,
0.02124258130788803,
0.15384380519390106,
-0.008504867553710938,
-0.03329915553331375,
0.08221435546875,
-0.02079775556921959,
0.12126664072275162,
0.22631289064884186,
0.005183173343539238,
0.007167986128479242,
0.06368214637041092,
0.0775478333234787,
-0.08606287837028503,
-0.01755833439528942,
-0.14746347069740295,
0.0993519276380539,
-0.018298882991075516,
0.03998067229986191,
0.2371349036693573,
-0.015580514445900917,
-0.10797033458948135,
-0.12863212823867798,
-0.12080935388803482,
-0.0737055316567421,
-0.20123997330665588,
0.07434900104999542,
0.054451651871204376,
-0.10933351516723633,
-0.02674965187907219,
0.21903567016124725,
-0.09313743561506271,
-0.24883060157299042,
0.07430189847946167,
0.21130144596099854,
-0.35558250546455383,
0.2508397102355957,
0.01387034822255373,
0.08755498379468918,
0.11644374579191208,
-0.023472221568226814,
0.25099557638168335,
0.06503822654485703,
-0.13581037521362305,
0.21887248754501343,
0.10094361752271652,
0.027279885485768318,
-0.03075045347213745,
-0.15937277674674988,
0.11272019892930984,
-0.1108919307589531,
-0.11359318345785141,
-0.11716633290052414,
-0.02640136331319809,
0.14919881522655487,
0.24824179708957672,
-0.004790215287357569,
0.18697898089885712,
-0.015020175836980343,
-0.02924659475684166,
0.05529347062110901,
-0.3654845952987671,
0.1159931942820549,
0.15023602545261383,
0.10072208195924759,
0.11159631609916687,
-0.08271005749702454,
0.008491337299346924,
-0.053307339549064636,
-0.04975392669439316,
-0.22967618703842163,
0.15446794033050537,
-0.08777125924825668,
0.0021090602967888117,
0.10538218915462494,
0.2112816423177719,
0.24445408582687378,
0.0376814529299736,
0.046024955809116364,
0.14022135734558105,
0.18763071298599243,
-0.01994575932621956,
-0.0552741102874279,
-0.14756307005882263,
0.040192581713199615,
-0.030823467299342155,
0.07654719799757004,
0.02839045226573944,
-0.08681915700435638,
0.006747109815478325,
0.29829564690589905,
-0.2180352658033371,
-0.20164170861244202,
-0.0896853506565094,
0.28768131136894226,
-0.031214695423841476,
-0.07389303296804428,
-0.07359479367733002,
0.17934101819992065,
-0.10803878307342529,
0.16737066209316254,
0.13996100425720215,
0.021782275289297104,
0.20845508575439453,
0.0036606150679290295,
0.06321506202220917,
0.2769201993942261,
0.013169094920158386,
-0.007426369469612837,
0.10374316573143005,
0.2562718093395233,
-0.04582260176539421,
0.07915501296520233,
-0.020799223333597183,
-0.24397802352905273,
-0.09301141649484634,
-0.03819945082068443,
0.003334285458549857,
0.03512289747595787,
-0.0105802146717906,
0.1507483273744583,
-0.13245436549186707,
-0.06592428684234619,
-0.20760464668273926,
0.10681416839361191,
-0.03804532065987587,
0.007622305303812027,
0.011643769219517708,
-0.02890353836119175,
-0.017023853957653046,
-0.04496539384126663,
0.11753086000680923,
0.01794329844415188,
-0.051970165222883224,
0.01723921112716198,
-0.019962061196565628,
0.03109103813767433,
0.35262900590896606,
-0.15119177103042603,
0.0613100603222847,
0.10670647025108337,
0.07427401840686798,
0.14611467719078064,
0.04034778103232384,
-0.028107549995183945,
-0.011719593778252602,
-0.12519173324108124,
-0.11026494204998016,
0.1192815750837326,
-0.03193322941660881,
-0.28068047761917114,
0.03535393998026848,
0.055742472410202026,
0.07595944404602051,
-0.36822524666786194,
0.04765981435775757,
0.11723605543375015,
-0.1121685728430748,
-0.004617389757186174,
0.07665899395942688,
0.28595495223999023,
0.12827569246292114,
0.12033598124980927,
0.055523794144392014,
0.049819108098745346,
0.195296972990036,
0.13217750191688538,
0.04280643165111542,
-0.0831184834241867,
-0.23106588423252106,
-0.01173093169927597,
-0.07857482135295868,
0.03725136071443558,
-0.06944701820611954,
0.040868353098630905,
0.21413347125053406,
0.13066841661930084,
-0.09780839830636978,
-0.02373209036886692,
-0.22036445140838623,
0.033215366303920746,
0.009270788170397282,
0.0470605343580246,
-0.03724919632077217,
-0.1944582462310791,
-0.20635855197906494,
-0.022128330543637276,
-0.21086691319942474,
0.18934397399425507,
0.21446113288402557,
0.14928090572357178,
-0.026200251653790474,
0.16033589839935303,
-0.31136056780815125,
-0.05091167613863945,
0.058320142328739166,
-0.04281111806631088,
-0.1440340280532837,
0.18947972357273102,
-0.020425977185368538,
-0.14463718235492706,
-0.2149907797574997,
0.004839617293328047,
-0.18521711230278015,
-0.11738153547048569,
-0.0016337272245436907,
0.16225367784500122,
-0.18917818367481232,
-0.07118622213602066,
-0.0234476737678051,
0.03180916607379913,
-0.021028848364949226,
0.12654942274093628,
0.14619629085063934,
0.030530331656336784,
0.055144209414720535,
-0.1691647171974182,
0.11668288707733154,
0.19604112207889557,
-0.0742839053273201,
0.19572465121746063,
0.11503040790557861,
-0.06629028916358948,
0.12000244855880737,
-0.12758341431617737,
0.05936872959136963,
0.04656817764043808,
-0.0009608886321075261,
0.2717052400112152,
-0.06083742529153824,
-0.10320117324590683,
0.02854246087372303,
0.02231895923614502,
-0.05852112919092178,
-0.19613538682460785,
-0.18473371863365173,
-0.195765882730484,
0.21529076993465424,
0.08143848180770874,
-0.06641028076410294,
-0.044008951634168625,
-0.30051326751708984,
-0.2852407991886139,
-0.03010726347565651,
-0.08058563619852066,
-0.1407175064086914,
-0.09743306785821915,
0.05226046219468117,
-0.1380850374698639,
-0.2869208753108978,
-0.018911486491560936,
0.19731564819812775,
-0.07734546065330505,
-0.08929622173309326,
0.04542940482497215,
0.1502324938774109,
0.20934925973415375,
0.1675359606742859,
0.0454578660428524,
0.015395212918519974,
0.034114401787519455,
-0.04082535579800606,
0.11532122641801834,
-0.14741173386573792,
-0.0691218301653862,
-0.15026211738586426,
0.14041292667388916,
0.053412094712257385,
0.07350791990756989,
-0.06495711207389832,
-0.2185622900724411,
-0.022351371124386787,
0.06276718527078629,
0.17319771647453308,
-0.06055949628353119,
-0.18859408795833588,
0.0635676234960556,
0.09139543771743774,
-0.02516857162117958,
-0.19064317643642426,
0.1851978600025177,
0.005434029269963503,
-0.07210589200258255,
-0.1256871074438095,
0.13733790814876556,
-0.00043435944826342165,
0.0998254120349884,
-0.05582364276051521,
0.02745470590889454,
-0.007199396844953299,
-0.13730911910533905,
-0.1309264898300171,
0.17258799076080322,
0.14545825123786926,
0.05798788741230965,
-0.22167688608169556,
-0.07356725633144379,
0.25535815954208374,
0.06414107233285904,
0.07929167151451111,
0.09662972390651703,
-0.18135400116443634,
-0.14647500216960907,
-0.04003562405705452,
-0.0001260333083337173,
-0.11361292004585266,
-0.01779562421143055,
0.17712286114692688,
-0.08576598018407822,
0.47031402587890625,
0.10914391279220581,
-0.02239113673567772,
-0.03061918541789055,
0.06153534725308418,
0.09409977495670319,
0.28078150749206543,
-0.21912918984889984,
0.3408830463886261,
-0.15692557394504547,
-0.08266102522611618,
-0.08392469584941864,
0.09458419680595398,
0.32556426525115967,
0.1431761384010315,
0.053811173886060715,
-0.04280358552932739,
-0.12805399298667908,
-0.018012631684541702,
0.07750708609819412,
-0.08807697892189026,
0.3918534517288208,
-0.34910711646080017,
0.10747041553258896,
-0.1965816766023636,
-0.17005428671836853,
0.13898086547851562,
-0.007548047695308924,
-0.14288479089736938,
0.043565534055233,
-0.019851256161928177,
0.019229620695114136,
-0.19161690771579742,
0.16573572158813477,
0.13503682613372803,
0.05003562569618225,
-0.09399627894163132,
-0.037505313754081726,
-0.2471819370985031,
-0.005310794338583946,
-0.16644446551799774,
0.022421957924962044,
0.1552322655916214,
0.052684929221868515,
-0.4611875116825104,
0.07310579717159271,
-0.11626259982585907,
0.1368953436613083,
0.1957702338695526,
-0.061241064220666885,
0.004052643198519945,
0.13723130524158478,
0.16496363282203674,
-0.013520263135433197,
-0.06248494237661362,
0.15231749415397644,
0.2229893058538437,
-0.19813738763332367,
-0.25000885128974915,
0.22137995064258575,
0.19676317274570465,
0.004161247983574867,
-0.09418234974145889,
0.06154443323612213,
0.0059547447599470615,
-0.015500912442803383,
-0.10260215401649475,
0.05179610103368759,
0.1422412246465683,
-0.03069406934082508,
-0.05685165897011757,
-0.05502437800168991,
-0.03507917746901512,
-0.16149277985095978,
0.003798944177106023,
-0.029883429408073425,
0.23640811443328857,
0.07446248084306717,
0.11893890798091888,
-0.18813303112983704,
-0.17469945549964905,
0.010292557999491692,
-0.06768076866865158,
0.13037927448749542,
-0.0177703145891428,
-0.09961951524019241,
0.05979475751519203,
0.08122175186872482,
0.15182040631771088,
-0.03605588525533676,
0.14573988318443298,
0.15393991768360138,
-0.05160106346011162,
0.058765627443790436,
-0.2088763564825058,
-0.06515175104141235,
0.14298084378242493,
-0.014628273434937,
-0.03940081596374512,
-0.0020121957641094923,
-0.036894556134939194,
-0.13807353377342224,
0.1993517279624939,
-0.10352321714162827,
0.06698177754878998,
0.038342203944921494,
-0.03606244921684265,
0.1579977422952652,
-0.019368035718798637,
-0.08414619415998459,
-0.010691501200199127,
-0.042410727590322495,
0.02842479757964611,
0.0766620934009552,
0.08794403821229935,
0.2331290990114212,
0.015227976255118847,
0.06812924891710281,
0.05249165743589401,
-0.09213224053382874,
-0.27968844771385193,
0.007841878570616245,
0.10037824511528015,
-0.14140400290489197,
-0.12212126702070236,
0.04335605725646019,
-0.06923853605985641,
0.03786154463887215,
-0.05114927887916565,
-0.05008930712938309,
-0.008047319017350674
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. ; fusion of C2 and C3 ; and delayed bone age .Digital clubbing, in the presence and in the absence of pulmonary abnormalities, has also been reported .Other manifestationsJoint laxity , including hip dislocation Protuberant abdomen in five of the first 17 cases reported Obesity Optic and chorioretinal atrophy , keratitis and pathologic myopia Erosive cystitis (one individual) Dental dysplasia Autoimmune adrenal failure (one individual) Prognosis. The severity of prolidase deficiency is quite variable: in some individuals skin ulcerations lead to amputation of one or all toes , whereas others remain entirely asymptomatic.Two individuals diagnosed through systematic urinary newborn screening in Quebec remained asymptomatic 14 years later .A man age 26 years, whose younger sister was affected, had imidodipeptiduria and prolidase deficiency in erythrocytes but no clinical manifestations .A woman age 29 years, the sister of an affected individual, had absence of prolidase activity in serum or erythrocytes, but no skin ulcers or other clinical manifestations of prolidase | [
-0.0798613652586937,
0.11969614028930664,
0.04565270617604256,
-0.17289477586746216,
0.11192651838064194,
0.07850661873817444,
-0.043641045689582825,
-0.09336548298597336,
-0.20524945855140686,
-0.12419018894433975,
0.17170698940753937,
0.21748086810112,
0.15231244266033173,
0.05667109414935112,
-0.10959073156118393,
0.10217049717903137,
0.04272738844156265,
-0.06723824888467789,
-0.13293062150478363,
-0.05095749720931053,
0.007605001796036959,
-0.11009710282087326,
0.19218936562538147,
0.181830033659935,
0.12881271541118622,
-0.04418894276022911,
0.06244426220655441,
0.10017220675945282,
-0.06072711944580078,
0.09565968811511993,
-0.0516434982419014,
-0.14576154947280884,
0.10836244374513626,
-0.2202572077512741,
0.13254712522029877,
0.026963861659169197,
-0.035138167440891266,
0.03682826831936836,
0.1681099832057953,
-0.05114373192191124,
-0.03912539407610893,
0.010498281568288803,
0.02334892749786377,
0.02063632383942604,
-0.051515642553567886,
-0.09104043990373611,
-0.024731852114200592,
0.09304584562778473,
-0.12389834970235825,
0.09120883792638779,
0.20622770488262177,
-0.014579121954739094,
-0.020043183118104935,
0.024848496541380882,
0.13604265451431274,
0.036361899226903915,
-0.011638163588941097,
0.01202018465846777,
-0.13017113506793976,
0.04259913042187691,
0.1178051233291626,
0.049920979887247086,
-0.019095154479146004,
-0.2920149862766266,
0.24449190497398376,
0.09399683773517609,
-0.048699915409088135,
-0.11290423572063446,
-0.07602944225072861,
-0.01989888958632946,
0.3850294053554535,
0.004446482751518488,
0.1909136325120926,
-0.03071882762014866,
-0.12760569155216217,
-0.1624327301979065,
0.13957858085632324,
-0.03462240844964981,
-0.009806059300899506,
-0.22474518418312073,
-0.1206251010298729,
-0.09558036923408508,
-0.14964497089385986,
0.042746081948280334,
-0.04735835641622543,
0.1595633327960968,
0.03254322707653046,
0.0827266126871109,
0.17840848863124847,
0.05617057904601097,
0.05504360795021057,
-0.24593585729599,
-0.04678582400083542,
-0.14740492403507233,
-0.015362964011728764,
-0.057851266115903854,
-0.015109783969819546,
-0.0486118346452713,
-0.04521115496754646,
0.12921850383281708,
0.10212624818086624,
0.05778719484806061,
0.028608858585357666,
0.056233882904052734,
0.024693405255675316,
-0.04510532692074776,
-0.14591722190380096,
0.06910305470228195,
-0.0773385763168335,
0.07289842516183853,
0.19623829424381256,
0.013346593827009201,
-0.07405927777290344,
-0.09083867818117142,
-0.1089368388056755,
0.15082885324954987,
0.05866383761167526,
-0.04602564871311188,
-0.08563774079084396,
-0.18782973289489746,
-0.02677326090633869,
0.014834009110927582,
-0.1005682423710823,
-0.12086645513772964,
0.14973801374435425,
0.1485007405281067,
-0.03673994168639183,
0.07141394913196564,
0.05964978411793709,
-0.12151073664426804,
-0.017646700143814087,
-0.17185428738594055,
-0.0608343742787838,
-0.29208657145500183,
0.0462932325899601,
-0.06972169876098633,
-0.1731472611427307,
-0.09605462849140167,
-0.05507161468267441,
-0.07090223580598831,
0.06847383081912994,
-0.05324196815490723,
0.26737064123153687,
0.3575141727924347,
-0.09726374596357346,
0.13068513572216034,
0.29493728280067444,
0.12800084054470062,
0.07022776454687119,
0.009564723819494247,
-0.03384551405906677,
0.020666800439357758,
0.37615901231765747,
0.02334664762020111,
0.02321571484208107,
0.0661604106426239,
-0.06571879237890244,
0.06348983198404312,
-0.23943424224853516,
0.05549370124936104,
0.05596647039055824,
-0.14107856154441833,
0.10620173811912537,
-0.10171070694923401,
-0.02329644002020359,
-0.05423375964164734,
-0.05577199161052704,
-0.09052734822034836,
-0.05684109404683113,
-0.028193632140755653,
-0.08766020834445953,
0.09571322053670883,
-0.12626661360263824,
0.08357348293066025,
0.19274471700191498,
-0.06991412490606308,
-0.00110563263297081,
-0.014092874713242054,
0.007937907241284847,
0.0802207887172699,
0.011356736533343792,
0.03160827234387398,
-0.09021557867527008,
-0.09283137321472168,
-0.05548350512981415,
-0.1585359424352646,
0.002636456163600087,
0.01141874585300684,
0.012993564829230309,
0.16385893523693085,
0.08488477021455765,
0.02497999370098114,
-0.026074407622218132,
-0.15276584029197693,
0.09888610243797302,
-0.1730717271566391,
0.04547317698597908,
-0.019228382036089897,
-0.06938821077346802,
-0.000060538353864103556,
0.18526802957057953,
-0.1719105839729309,
0.1353905200958252,
-0.0970807671546936,
-0.11729610711336136,
-0.05709874629974365,
-0.07489833980798721,
-0.016805334016680717,
-0.12344926595687866,
0.24518083035945892,
0.045707687735557556,
0.08468464016914368,
-0.09621389955282211,
0.09817703068256378,
-0.0476551279425621,
0.040710270404815674,
-0.157074436545372,
-0.015208697877824306,
-0.11239588260650635,
0.05960637703537941,
-0.008218660019338131,
0.05493110045790672,
-0.03662298619747162,
-0.18111856281757355,
-0.09879828989505768,
0.1875494122505188,
-0.02345552295446396,
0.039360519498586655,
0.04638855531811714,
0.21347393095493317,
-0.0005199780571274459,
0.1069338470697403,
0.06624501198530197,
0.0717666745185852,
-0.09127573668956757,
-0.13360297679901123,
-0.012228885665535927,
0.24647760391235352,
0.05442818999290466,
0.07936659455299377,
-0.18060074746608734,
-0.011708498932421207,
0.0669364258646965,
-0.1489001363515854,
-0.06672476977109909,
0.1402709186077118,
-0.02744591236114502,
0.0874406099319458,
-0.11985355615615845,
0.06354135274887085,
-0.02886788547039032,
-0.17899970710277557,
0.2077355831861496,
-0.13142108917236328,
-0.349150151014328,
0.09652014821767807,
0.177983820438385,
-0.03095771186053753,
0.25201261043548584,
0.0766945481300354,
0.09992578625679016,
0.031051041558384895,
0.09247506409883499,
-0.1499824821949005,
0.006301159970462322,
-0.010247060097754002,
-0.11998876184225082,
0.16925764083862305,
-0.10470829904079437,
-0.16099976003170013,
0.05656816065311432,
0.007863943465054035,
0.2315051257610321,
0.15532852709293365,
-0.0032907738350331783,
0.0334303081035614,
-0.2633691132068634,
0.11831997334957123,
0.2090592086315155,
-0.1089673638343811,
0.12093499302864075,
-0.02252361737191677,
-0.25714966654777527,
-0.002667071996256709,
0.15003009140491486,
0.03078235499560833,
0.03678814694285393,
0.14385932683944702,
-0.07335562258958817,
-0.018975399434566498,
0.08485401421785355,
0.2057347446680069,
-0.031219590455293655,
-0.040290068835020065,
0.050094518810510635,
0.05316443368792534,
-0.19247876107692719,
-0.1636268049478531,
0.22170405089855194,
-0.023249808698892593,
0.19179213047027588,
0.18729040026664734,
0.04932112991809845,
0.06443486362695694,
0.054173875600099564,
-0.07818080484867096,
-0.04889984801411629,
0.118694007396698,
-0.167978435754776,
-0.023569529876112938,
-0.1490190476179123,
0.05279441922903061,
-0.005739131011068821,
-0.13975240290164948,
0.07397421449422836,
-0.0095809455960989,
-0.13317465782165527,
0.1939636766910553,
0.1468195766210556,
0.05016110837459564,
0.20064972341060638,
-0.04029764607548714,
0.09398631751537323,
0.2887493968009949,
0.062354013323783875,
0.06076959893107414,
-0.12748582661151886,
-0.09666238725185394,
-0.06662393361330032,
0.035538479685783386,
0.07886689901351929,
0.020629145205020905,
0.0351543165743351,
-0.03110392391681671,
0.03500325605273247,
0.1293811947107315,
0.054155297577381134,
-0.12999767065048218,
-0.09540258347988129,
0.017706096172332764,
-0.05008591338992119,
-0.05658941715955734,
0.06512732058763504,
-0.13898010551929474,
-0.07557633519172668,
0.029570244252681732,
0.06159614771604538,
0.1292402595281601,
0.0939381867647171,
-0.02116047963500023,
-0.05749441310763359,
-0.05231621488928795,
-0.06305203586816788,
-0.19122762978076935,
0.12635363638401031,
0.213693767786026,
-0.054372355341911316,
-0.09189100563526154,
0.15499141812324524,
-0.11490876227617264,
-0.191897451877594,
0.1304282695055008,
0.23369434475898743,
-0.26486271619796753,
0.2654059827327728,
-0.0012425110908225179,
0.13742950558662415,
0.016202563419938087,
0.0011021473910659552,
-0.10113303363323212,
0.1404164433479309,
-0.06862490624189377,
0.22637751698493958,
0.1413007527589798,
-0.07855571806430817,
0.05762377381324768,
-0.11455954611301422,
0.053231410682201385,
-0.04481381177902222,
-0.13125954568386078,
-0.013765258714556694,
0.08829213678836823,
0.12688171863555908,
0.20801971852779388,
0.03615918755531311,
0.12259567528963089,
-0.07941514253616333,
0.09514323621988297,
0.08328310400247574,
-0.1325293630361557,
0.16542768478393555,
0.1286212056875229,
0.05679784715175629,
0.06470219045877457,
-0.2549441158771515,
0.027255438268184662,
-0.03383663296699524,
-0.06334728747606277,
-0.12326480448246002,
0.07124205678701401,
0.055462826043367386,
0.0000938216398935765,
0.030546510592103004,
0.14716947078704834,
0.1237277239561081,
0.14052027463912964,
0.029327012598514557,
0.07465164363384247,
0.06414101272821426,
-0.06955704092979431,
-0.044660720974206924,
-0.08827368915081024,
-0.015338272787630558,
-0.06846638023853302,
-0.008985146880149841,
-0.09130489826202393,
-0.08893310278654099,
-0.013312633149325848,
0.10816677659749985,
-0.1085313931107521,
-0.16276603937149048,
-0.1403110772371292,
0.2754613757133484,
-0.006682146806269884,
-0.14223983883857727,
0.04162649065256119,
0.09509100019931793,
0.06999993324279785,
0.04631093144416809,
0.06542859971523285,
0.18031816184520721,
0.11441469937562943,
0.03804628923535347,
-0.040345605462789536,
0.25522950291633606,
0.02542705461382866,
-0.00117423792835325,
0.0416867770254612,
0.274575412273407,
0.07552225142717361,
0.1614018678665161,
0.03614025190472603,
-0.09312538057565689,
0.027783339843153954,
-0.09553792327642441,
0.0952465757727623,
0.018669430166482925,
0.056921664625406265,
0.12821660935878754,
0.01021223608404398,
-0.022630468010902405,
-0.05403273552656174,
0.18459782004356384,
-0.01961333118379116,
-0.05226926505565643,
0.06914582848548889,
-0.06676565855741501,
-0.13883981108665466,
-0.06287658214569092,
0.045682359486818314,
0.04919181019067764,
0.1435282826423645,
0.05896618217229843,
-0.1310988813638687,
-0.0385047048330307,
0.13748683035373688,
-0.11565139889717102,
0.10747065395116806,
0.03533840551972389,
0.03831801936030388,
0.07817316800355911,
0.0791962519288063,
-0.018872564658522606,
0.039336804300546646,
-0.09286417812108994,
0.056042417883872986,
-0.038554005324840546,
0.06796550005674362,
-0.13025112450122833,
0.04708058759570122,
0.04658454284071922,
0.05707560107111931,
-0.2981643080711365,
0.04046878218650818,
0.040619369596242905,
-0.11727063357830048,
0.13048315048217773,
-0.034838903695344925,
0.15032339096069336,
0.04027016460895538,
-0.03872957453131676,
0.06752969324588776,
0.029990410432219505,
0.3048405647277832,
0.14642582833766937,
0.027769921347498894,
-0.05153205990791321,
-0.21289843320846558,
0.035211894661188126,
-0.10806538164615631,
0.03985298424959183,
-0.13374124467372894,
-0.0008662010077387094,
0.17157360911369324,
0.10220571607351303,
-0.1109699010848999,
0.021385833621025085,
-0.06054668128490448,
0.05536196380853653,
0.07866518199443817,
0.06388062238693237,
-0.029550310224294662,
-0.22732555866241455,
-0.22031816840171814,
-0.019594203680753708,
-0.1593540757894516,
0.05613059550523758,
0.10620710998773575,
0.12114429473876953,
0.01002231240272522,
0.05010151118040085,
-0.10319703817367554,
0.027489984408020973,
0.15317782759666443,
-0.1068645492196083,
-0.09300296753644943,
-0.04529058188199997,
0.016258930787444115,
-0.16452208161354065,
-0.2011530101299286,
-0.15169401466846466,
-0.0876564234495163,
0.04106783866882324,
0.0007309342036023736,
0.04715219885110855,
-0.03389764204621315,
0.01128174364566803,
-0.0005594826070591807,
0.02599099650979042,
-0.007292213849723339,
0.07938036322593689,
0.13587123155593872,
0.011620971374213696,
0.08816108107566833,
-0.2044239342212677,
0.03276751562952995,
0.015106728300452232,
-0.09760800749063492,
0.014871932566165924,
0.1561097651720047,
-0.01912376470863819,
0.16086600720882416,
-0.09686920046806335,
0.07937261462211609,
-0.000013824686902808025,
0.00007451103010680526,
0.14782752096652985,
-0.07411782443523407,
-0.16781888902187347,
-0.05880921706557274,
-0.05557724088430405,
-0.03028697893023491,
-0.1134219616651535,
-0.01670840010046959,
-0.06894470751285553,
0.1379426121711731,
0.0077252876944839954,
-0.006840777583420277,
-0.07811107486486435,
-0.17649833858013153,
-0.12285370379686356,
-0.014875723980367184,
0.0013642560224980116,
-0.17580676078796387,
-0.256673127412796,
-0.04854385554790497,
-0.11559230834245682,
-0.14666052162647247,
-0.09076735377311707,
0.151952862739563,
0.004034578334540129,
-0.15398330986499786,
0.02777617610991001,
0.008059285581111908,
0.07777886837720871,
0.14826330542564392,
-0.04265981540083885,
0.06616728007793427,
0.023407233878970146,
0.09147898852825165,
0.1213817298412323,
-0.10620633512735367,
-0.12730680406093597,
-0.170754536986351,
0.09016046673059464,
0.07635688036680222,
0.051441341638565063,
-0.2408410757780075,
0.005030575208365917,
-0.0792480856180191,
-0.09528589248657227,
0.21429802477359772,
-0.0919695794582367,
-0.03275027126073837,
-0.0028116563335061073,
0.08568628877401352,
0.0717431828379631,
-0.18554651737213135,
0.016067951917648315,
0.146400585770607,
0.10240484774112701,
-0.11975892633199692,
0.11614058911800385,
-0.08362121134996414,
0.23121200501918793,
-0.07196049392223358,
-0.01751580461859703,
-0.08900190889835358,
-0.01684577204287052,
-0.18685899674892426,
0.15070050954818726,
0.031792521476745605,
-0.014954808168113232,
-0.23402561247348785,
0.02046174742281437,
0.059828028082847595,
0.024082500487565994,
0.06868927925825119,
0.059486571699380875,
0.11198538541793823,
-0.048489172011613846,
0.00027265734388493,
-0.004801001399755478,
0.1106652170419693,
-0.09172949194908142,
0.24105200171470642,
-0.026800228282809258,
0.2614396810531616,
0.022607823833823204,
0.07383009791374207,
0.004062389023602009,
0.07445963472127914,
-0.0018506742781028152,
0.13483993709087372,
-0.14236117899417877,
0.23678013682365417,
-0.028247902169823647,
-0.1184733584523201,
0.14927875995635986,
0.008840087801218033,
0.13195502758026123,
0.10046928375959396,
-0.11751013994216919,
-0.014605140313506126,
-0.11729028820991516,
-0.06304086744785309,
0.1064060851931572,
0.0213420782238245,
0.02090168371796608,
-0.2243034839630127,
0.008005625568330288,
-0.1714155524969101,
-0.18358537554740906,
0.13431285321712494,
0.005894176661968231,
0.03021869622170925,
0.08874458074569702,
-0.024834128096699715,
-0.039653051644563675,
-0.11446226388216019,
0.04678117483854294,
0.1411086618900299,
0.03867555037140846,
-0.013180100359022617,
-0.04477907344698906,
-0.07695525884628296,
-0.0010460714111104608,
-0.2429697960615158,
-0.04990699514746666,
0.15084032714366913,
-0.14817401766777039,
-0.3321601450443268,
-0.11562618613243103,
-0.11351391673088074,
0.07656902074813843,
0.18635115027427673,
0.023763621225953102,
0.03416648134589195,
0.27211180329322815,
-0.02042420767247677,
-0.1175534725189209,
0.01977621763944626,
0.08483169972896576,
0.13823051750659943,
-0.04335520416498184,
-0.26238152384757996,
0.2203829437494278,
0.2445586919784546,
-0.022756502032279968,
-0.2038545310497284,
0.013593703508377075,
-0.007994305342435837,
-0.08252284675836563,
0.021033842116594315,
0.04248035326600075,
0.14186407625675201,
0.13467937707901,
-0.10850474238395691,
-0.09166830778121948,
0.06511080265045166,
-0.1023850217461586,
-0.08829314261674881,
-0.007740682456642389,
0.10997051000595093,
0.017429674044251442,
0.04613544046878815,
-0.1812543123960495,
-0.050645675510168076,
-0.0003537010634317994,
0.10790789872407913,
0.0646018534898758,
-0.033752743154764175,
-0.06444548070430756,
-0.05450824648141861,
0.01732645370066166,
0.08443985134363174,
-0.07820814847946167,
-0.0063666063360869884,
0.16365517675876617,
0.004861956927925348,
-0.01933838240802288,
-0.23572179675102234,
-0.08921251446008682,
0.09004253149032593,
-0.0066573540680110455,
0.016658974811434746,
0.035101767629384995,
-0.09002113342285156,
-0.06858472526073456,
0.06086231768131256,
0.014047319069504738,
0.040338948369026184,
-0.0687561109662056,
-0.024710888043045998,
0.22709901630878448,
-0.035279836505651474,
-0.07698805630207062,
0.04937398433685303,
-0.07040902227163315,
-0.01217300072312355,
0.03124411776661873,
0.019619090482592583,
0.08439402282238007,
0.09109310060739517,
0.11590266972780228,
-0.06268389523029327,
-0.11693806201219559,
-0.18949085474014282,
0.08561486005783081,
0.1393195390701294,
-0.05525408685207367,
-0.04266689717769623,
-0.025155754759907722,
-0.05214710161089897,
-0.05353548750281334,
0.07741600275039673,
-0.06710963696241379,
0.01873350888490677
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. skin ulcerations lead to amputation of one or all toes , whereas others remain entirely asymptomatic.Two individuals diagnosed through systematic urinary newborn screening in Quebec remained asymptomatic 14 years later .A man age 26 years, whose younger sister was affected, had imidodipeptiduria and prolidase deficiency in erythrocytes but no clinical manifestations .A woman age 29 years, the sister of an affected individual, had absence of prolidase activity in serum or erythrocytes, but no skin ulcers or other clinical manifestations of prolidase deficiency .In most instances, individuals with prolidase deficiency experience severe morbidity and early death, usually due to infection.The individual with probable prolidase deficiency reported by Goodman et al had died of influenza by the time of a follow-up biochemical report four years later . He was about age 50 years at the time of death .The female reported by Lapiere & Nusgens died at age 36 years ; she had superinfection of skin ulcers with Pseudomonas | [
-0.10494471341371536,
0.10095755010843277,
-0.022511037066578865,
-0.18754516541957855,
0.0730937272310257,
0.09903765469789505,
-0.042503684759140015,
-0.054616838693618774,
-0.12330883741378784,
-0.07576398551464081,
0.15975220501422882,
0.2045840620994568,
0.1599351018667221,
-0.05477437749505043,
-0.0627971962094307,
0.08265294134616852,
0.10543891042470932,
-0.054745107889175415,
-0.03577427193522453,
0.006483730394393206,
0.0784701555967331,
-0.07773096859455109,
0.1933087259531021,
0.17446981370449066,
0.1591382920742035,
0.008154257200658321,
0.05548754334449768,
0.01756846345961094,
-0.037094369530677795,
0.12718629837036133,
-0.007027820684015751,
-0.055893946439027786,
-0.015939418226480484,
-0.23809298872947693,
0.1283932775259018,
0.0049711256287992,
-0.051841311156749725,
-0.002416762989014387,
0.178037628531456,
0.00169052102137357,
-0.09788569808006287,
-0.09116210043430328,
0.0463888943195343,
0.043401628732681274,
-0.03393092378973961,
-0.06730993092060089,
-0.016813527792692184,
0.10045106709003448,
-0.15222205221652985,
0.13606008887290955,
0.2058580070734024,
-0.06268025934696198,
-0.01897346042096615,
-0.02167736180126667,
0.13246771693229675,
0.13498809933662415,
0.0019559042993932962,
0.018531976267695427,
-0.12586845457553864,
-0.018026577308773994,
0.08189697563648224,
0.0018286003032699227,
-0.016827084124088287,
-0.3090366721153259,
0.2536723017692566,
0.09460482001304626,
0.03154607117176056,
-0.17507846653461456,
-0.19576436281204224,
-0.06718870252370834,
0.3753518760204315,
0.005347238853573799,
0.26797258853912354,
0.052047375589609146,
-0.09234581887722015,
-0.001260513672605157,
0.16087324917316437,
-0.0620853416621685,
-0.010973593220114708,
-0.1825183480978012,
-0.21147416532039642,
0.031964924186468124,
-0.06339064240455627,
0.10088195651769638,
-0.0757811963558197,
0.2081921398639679,
0.17323166131973267,
0.12208279222249985,
0.16138944029808044,
0.025824876502156258,
0.0010026382515206933,
-0.22339674830436707,
0.003389232326298952,
-0.21145060658454895,
0.011254686862230301,
-0.16994914412498474,
-0.011278839781880379,
-0.018156027421355247,
-0.07683349400758743,
0.1571795642375946,
0.1499614268541336,
0.05393233150243759,
0.014174592681229115,
0.03088856302201748,
0.07247061282396317,
0.025099406018853188,
-0.14325879514217377,
-0.06447410583496094,
-0.03769448399543762,
0.06089814379811287,
0.17524844408035278,
-0.026780685409903526,
-0.06373663991689682,
0.006283302325755358,
-0.1432981640100479,
0.08982810378074646,
0.15790529549121857,
-0.10520091652870178,
-0.018459947779774666,
-0.10495617985725403,
-0.04929787665605545,
0.095365010201931,
0.020450670272111893,
-0.18606828153133392,
0.17100095748901367,
0.16501325368881226,
-0.025857172906398773,
0.12232993543148041,
0.13327454030513763,
-0.11903025954961777,
0.03721213340759277,
-0.05980165675282478,
-0.03642453998327255,
-0.21792012453079224,
-0.10039792954921722,
-0.010070462711155415,
-0.17095063626766205,
-0.07033008337020874,
-0.0009833339136093855,
-0.09009303897619247,
-0.025553487241268158,
-0.03678671270608902,
0.1727624386548996,
0.34335407614707947,
-0.07250980287790298,
0.16578152775764465,
0.36266446113586426,
0.07104895263910294,
0.1416517198085785,
-0.000501477625221014,
0.01638120599091053,
-0.0029454200994223356,
0.3446347713470459,
-0.014890985563397408,
-0.06995809823274612,
0.0694177970290184,
-0.10342224687337875,
0.009136389009654522,
-0.19237035512924194,
0.10534290224313736,
0.09686148166656494,
-0.10096096992492676,
0.1502085030078888,
-0.04065034165978432,
0.018789498135447502,
-0.050294481217861176,
-0.12617315351963043,
0.020050277933478355,
0.03202182799577713,
0.05134187266230583,
-0.05656655877828598,
0.10181836038827896,
-0.10245606303215027,
0.07707604765892029,
0.2333216816186905,
-0.1360902041196823,
-0.00805595051497221,
-0.04538803920149803,
-0.03573211282491684,
0.16850104928016663,
-0.00034920923644676805,
0.011410449631512165,
-0.12522448599338531,
0.047817934304475784,
-0.04031527414917946,
-0.11566951870918274,
0.002002590335905552,
0.1676439791917801,
0.0713077113032341,
0.1983143836259842,
0.1960907131433487,
0.1033545732498169,
-0.006272223778069019,
-0.16634590923786163,
0.1595013439655304,
-0.1453121304512024,
0.01750076375901699,
0.0391622819006443,
-0.13402654230594635,
-0.0336582250893116,
0.13253706693649292,
-0.18222352862358093,
0.18468090891838074,
-0.08762283623218536,
-0.00840847846120596,
-0.014886738732457161,
-0.040045980364084244,
0.024696221575140953,
-0.02592337690293789,
0.2725178003311157,
0.040238186717033386,
0.07744768261909485,
-0.0885065570473671,
0.18728789687156677,
-0.057816918939352036,
-0.006916670594364405,
-0.2496279776096344,
-0.01614084281027317,
-0.09600057452917099,
-0.0845622792840004,
-0.029959777370095253,
0.040384337306022644,
-0.08336731046438217,
-0.1781829297542572,
0.03534052520990372,
0.01548363734036684,
-0.008984590880572796,
0.03243815153837204,
0.06425074487924576,
0.06540291756391525,
0.010670184157788754,
0.12465330213308334,
0.11380919069051743,
0.14028455317020416,
-0.11077059060335159,
-0.11656981706619263,
0.03942113369703293,
0.20889122784137726,
0.04425501450896263,
0.05188331753015518,
-0.22172439098358154,
0.01623443327844143,
0.08596117794513702,
-0.10371257364749908,
-0.010442611761391163,
0.07535164803266525,
-0.1160876452922821,
0.12599991261959076,
-0.13417381048202515,
0.11875492334365845,
-0.06197138503193855,
-0.12632876634597778,
0.18123403191566467,
-0.13722045719623566,
-0.39392152428627014,
0.06942547857761383,
0.18734633922576904,
-0.09781034290790558,
0.1608520895242691,
0.0027569846715778112,
0.04426570609211922,
-0.06074724346399307,
0.11028347164392471,
-0.08161814510822296,
0.07044722884893417,
0.028806248679757118,
-0.12569621205329895,
0.2358170449733734,
-0.18027755618095398,
-0.21999327838420868,
-0.02941235713660717,
0.011282218620181084,
0.17943398654460907,
0.10374890267848969,
-0.029224209487438202,
-0.04318401962518692,
-0.18414919078350067,
0.11080436408519745,
0.15734171867370605,
-0.02806636318564415,
0.05309966206550598,
0.030926652252674103,
-0.13997726142406464,
-0.017975518479943275,
0.17177388072013855,
0.0356736034154892,
0.043953727930784225,
0.17395298182964325,
-0.1430666148662567,
0.05518314614892006,
0.16737543046474457,
0.19113335013389587,
-0.11970672011375427,
-0.0460289865732193,
0.05121737718582153,
-0.0021945785265415907,
-0.1447327584028244,
-0.11872125416994095,
0.14231997728347778,
-0.01938108168542385,
0.12032006680965424,
0.21270868182182312,
-0.014668049290776253,
-0.05743580311536789,
-0.1107320636510849,
-0.13854314386844635,
0.015334408730268478,
0.0004692265938501805,
-0.15889443457126617,
0.10720236599445343,
-0.1244979202747345,
-0.009714978747069836,
-0.057943738996982574,
-0.1939927041530609,
0.03324679657816887,
0.03378256410360336,
-0.2305247187614441,
0.1335880607366562,
0.13044895231723785,
0.0873388722538948,
0.2448917180299759,
-0.0911172479391098,
0.10219721496105194,
0.22025083005428314,
-0.033181097358465195,
0.062404803931713104,
-0.1147494837641716,
-0.04751084744930267,
0.01688987761735916,
-0.022916264832019806,
0.05040818825364113,
0.01742827333509922,
0.0823068842291832,
-0.03853711485862732,
0.056336410343647,
0.021939296275377274,
0.17799194157123566,
-0.1511431187391281,
-0.07997196912765503,
0.00043982802890241146,
0.04672035202383995,
-0.13010273873806,
0.04288826510310173,
-0.13784180581569672,
-0.16372577846050262,
0.011434921063482761,
0.027748269960284233,
0.0429481565952301,
0.1890862137079239,
-0.0037424718029797077,
-0.05410041660070419,
-0.056358758360147476,
-0.03998161852359772,
-0.21068163216114044,
0.17235861718654633,
0.20920534431934357,
-0.0933326929807663,
-0.034723132848739624,
0.12632416188716888,
-0.10169823467731476,
-0.13197360932826996,
0.20193907618522644,
0.25668463110923767,
-0.20275235176086426,
0.27360111474990845,
0.10005561262369156,
0.15765714645385742,
0.00732811214402318,
-0.023145422339439392,
-0.1133284643292427,
0.022951995953917503,
-0.051904674619436264,
0.14277960360050201,
0.16835419833660126,
-0.06810683757066727,
0.13942568004131317,
-0.11238120496273041,
0.2017393708229065,
-0.02956720069050789,
-0.030388696119189262,
-0.05738944932818413,
0.15668316185474396,
0.20810556411743164,
0.2696340084075928,
0.08915890753269196,
0.13291841745376587,
-0.18671822547912598,
0.046849168837070465,
0.06592333316802979,
-0.05381496250629425,
0.12107978761196136,
0.17004406452178955,
-0.023994434624910355,
0.11582320928573608,
-0.25395405292510986,
0.09806232154369354,
-0.06962863355875015,
-0.11104602366685867,
-0.14958927035331726,
0.08956968784332275,
0.027320807799696922,
0.0042918226681649685,
0.108148492872715,
0.09082122892141342,
0.06482076644897461,
0.19902688264846802,
0.09882866591215134,
0.09629104286432266,
0.022122325375676155,
-0.13324052095413208,
0.03428145870566368,
-0.027690337970852852,
-0.03663570061326027,
-0.144947811961174,
0.06829866021871567,
-0.008679300546646118,
-0.022023508325219154,
0.07647503912448883,
0.14225035905838013,
-0.010694525204598904,
-0.1731472611427307,
-0.15780596435070038,
0.16043731570243835,
0.04789284989237785,
-0.06107455864548683,
0.011250928044319153,
0.05459345877170563,
-0.03825186938047409,
0.11181826889514923,
0.17989453673362732,
0.16790930926799774,
0.12856590747833252,
0.014140935614705086,
-0.02766747586429119,
0.26217833161354065,
0.026311665773391724,
0.0078048910945653915,
0.09987765550613403,
0.12019426375627518,
0.1128685474395752,
0.24324418604373932,
0.07417064160108566,
-0.12603256106376648,
-0.09153351932764053,
-0.12867897748947144,
0.04243039712309837,
-0.003361394861713052,
0.13469138741493225,
0.16680681705474854,
0.19848299026489258,
-0.014431598596274853,
-0.06812990456819534,
0.08465398102998734,
-0.07344931364059448,
-0.11549100279808044,
0.12122447788715363,
-0.09476261585950851,
-0.05433906987309456,
-0.007554215844720602,
0.04543142393231392,
-0.01309253554791212,
0.2825102210044861,
-0.0019477813038975,
-0.11977874487638474,
-0.04561620578169823,
0.177570179104805,
-0.15572592616081238,
0.04150235280394554,
-0.05562576651573181,
0.04760543629527092,
0.07478645443916321,
0.1242140531539917,
-0.04477175325155258,
-0.01847814954817295,
-0.12400533258914948,
0.0023045421112328768,
-0.06913665682077408,
0.062364041805267334,
-0.1591273546218872,
0.08125945925712585,
-0.05885665491223335,
0.00982371810823679,
-0.20608986914157867,
0.01794700138270855,
-0.005429801531136036,
-0.12793557345867157,
0.02365613728761673,
-0.04774165526032448,
0.133039653301239,
0.08126526325941086,
0.03289792686700821,
0.09321103245019913,
0.07047732919454575,
0.30400630831718445,
0.10434374958276749,
-0.05199198052287102,
-0.12905611097812653,
-0.2492513656616211,
0.11530651152133942,
-0.11027827113866806,
0.04684558883309364,
-0.06684127449989319,
0.06827600300312042,
0.3184111714363098,
0.08744098991155624,
-0.05812972038984299,
0.003735287580639124,
-0.08167129755020142,
0.10838112980127335,
0.20512372255325317,
0.11907371878623962,
-0.07912733405828476,
-0.18499276041984558,
-0.05635610595345497,
-0.08029965311288834,
-0.1752062737941742,
0.22019712626934052,
0.1353403627872467,
0.10406849533319473,
-0.021248383447527885,
0.08228486031293869,
-0.07384450733661652,
0.05484664440155029,
0.2501135766506195,
-0.01927812211215496,
-0.14264144003391266,
-0.0018623140640556812,
0.041653815656900406,
-0.260181725025177,
-0.172489732503891,
-0.08144830167293549,
-0.1388031542301178,
-0.019547801464796066,
0.043076373636722565,
0.03813452273607254,
0.025590864941477776,
-0.025904856622219086,
-0.05602158606052399,
0.02847295068204403,
0.006697718054056168,
0.055121224373579025,
0.027747925370931625,
-0.021011143922805786,
0.10169667750597,
-0.23374861478805542,
0.16172611713409424,
0.05717415735125542,
-0.14842377603054047,
-0.008822564035654068,
0.09042011946439743,
-0.00019817572319880128,
0.18453171849250793,
-0.029444914311170578,
0.09754570573568344,
-0.05926281586289406,
-0.043859995901584625,
0.08585473895072937,
-0.08264727145433426,
-0.1703934520483017,
-0.03223037347197533,
-0.04560630023479462,
-0.07742512226104736,
-0.03753502666950226,
-0.13409656286239624,
-0.02763116918504238,
0.17614011466503143,
-0.0780036598443985,
0.02333000861108303,
-0.022419042885303497,
-0.10894173383712769,
-0.035918544977903366,
-0.027973750606179237,
-0.00041425033123232424,
-0.19857755303382874,
-0.2696182429790497,
0.008378925733268261,
-0.12359745800495148,
-0.09699714928865433,
-0.15245909988880157,
0.08709312230348587,
-0.05270358920097351,
-0.16070610284805298,
0.054829906672239304,
0.09217178821563721,
0.04710017889738083,
0.11392383277416229,
-0.06118941307067871,
0.044829726219177246,
0.13520605862140656,
0.005654781125485897,
0.14109966158866882,
-0.1776103675365448,
-0.1783353090286255,
-0.179792121052742,
0.14324241876602173,
0.08844603598117828,
0.0970350056886673,
-0.2592375576496124,
0.04315590485930443,
-0.11482331901788712,
-0.12999457120895386,
0.17254522442817688,
-0.08831575512886047,
-0.16769981384277344,
-0.029714122414588928,
0.06307188421487808,
0.11091454327106476,
-0.26983708143234253,
0.10440471023321152,
0.07387860864400864,
0.2566378712654114,
-0.10372573882341385,
0.09587815403938293,
0.011415880173444748,
0.25267547369003296,
-0.02161753550171852,
-0.0246609877794981,
-0.22155103087425232,
0.00018084111798088998,
-0.18711936473846436,
0.19027675688266754,
0.1374967247247696,
0.059308312833309174,
-0.23644831776618958,
-0.03898492828011513,
0.12338238954544067,
0.04276367649435997,
-0.0622713640332222,
0.023103071376681328,
0.1492099165916443,
-0.08634757995605469,
-0.0379471629858017,
-0.0517750158905983,
0.15917931497097015,
-0.1396922916173935,
0.12634946405887604,
0.0019160513766109943,
0.35882309079170227,
0.034681811928749084,
-0.006240323651582003,
-0.10120236128568649,
0.033044129610061646,
-0.09076178073883057,
0.16440445184707642,
-0.1486784815788269,
0.29466354846954346,
-0.09887371212244034,
0.02784964069724083,
0.09953314065933228,
-0.05399543046951294,
0.09716092795133591,
-0.005916198715567589,
-0.15152686834335327,
0.08163446187973022,
-0.0070142862387001514,
0.017667755484580994,
0.048200156539678574,
0.04920116439461708,
0.1266459822654724,
-0.21482762694358826,
0.087342269718647,
-0.03943304717540741,
-0.11736761033535004,
0.03193720430135727,
-0.04452979192137718,
0.04393504559993744,
0.10755156725645065,
-0.04893144592642784,
-0.045369476079940796,
-0.03985435143113136,
0.14772914350032806,
0.18268746137619019,
-0.10430334508419037,
0.07993607223033905,
0.041619397699832916,
-0.06149214506149292,
-0.1366228610277176,
-0.1836608499288559,
-0.12594778835773468,
0.16642001271247864,
-0.0927857756614685,
-0.3145126700401306,
-0.07427241653203964,
-0.19766560196876526,
0.04178939387202263,
0.1558161824941635,
-0.0030219147447496653,
0.08602409064769745,
0.3217844069004059,
-0.02553107775747776,
-0.11610721796751022,
-0.05509015545248985,
0.07290160655975342,
0.09659607708454132,
-0.06077773869037628,
-0.14577698707580566,
0.25871583819389343,
0.17241662740707397,
-0.01870766468346119,
-0.14870861172676086,
0.059438977390527725,
0.03476228564977646,
-0.08344878256320953,
0.059496212750673294,
0.1347152590751648,
0.11090683937072754,
0.10725951194763184,
-0.14841899275779724,
-0.1213894858956337,
0.0710063949227333,
-0.11559146642684937,
-0.07392888516187668,
-0.02962573990225792,
0.06376753002405167,
0.016720769926905632,
0.16763071715831757,
-0.13713975250720978,
-0.03195418044924736,
-0.04265758395195007,
0.11419916898012161,
0.03251674398779869,
-0.06232105940580368,
-0.039081573486328125,
-0.06008560210466385,
0.024601858109235764,
-0.0049604312516748905,
-0.03834955394268036,
-0.011549197137355804,
0.17202889919281006,
-0.04283483326435089,
-0.15070156753063202,
-0.18992666900157928,
-0.09134845435619354,
0.1531028300523758,
-0.05589936301112175,
0.07365981489419937,
0.07186692208051682,
-0.05413356423377991,
-0.05060386285185814,
0.1581367552280426,
0.04262557253241539,
0.07973752170801163,
-0.036968979984521866,
-0.04750756546854973,
0.24230317771434784,
0.1347266435623169,
-0.18927805125713348,
0.009112206287682056,
-0.10901647806167603,
-0.10739540308713913,
0.04166942089796066,
0.09437446296215057,
-0.033350542187690735,
0.12987977266311646,
0.03704312443733215,
0.024170788004994392,
-0.07731612771749496,
-0.19738580286502838,
0.07460350543260574,
0.11316105723381042,
-0.10438675433397293,
-0.06838656961917877,
-0.0023442863021045923,
-0.05444547161459923,
-0.04948063939809799,
0.008383478969335556,
-0.03872678801417351,
0.02968924678862095
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. other clinical manifestations of prolidase deficiency .In most instances, individuals with prolidase deficiency experience severe morbidity and early death, usually due to infection.The individual with probable prolidase deficiency reported by Goodman et al had died of influenza by the time of a follow-up biochemical report four years later . He was about age 50 years at the time of death .The female reported by Lapiere & Nusgens died at age 36 years ; she had superinfection of skin ulcers with Pseudomonas aeruginosa, which lead to septic shock and disseminated intravascular coagulation .A female died of a fungal infection and disseminated intravascular coagulation .A girl age 16 years with prolidase deficiency and SLE developed cellulitis of the leg, followed by adult respiratory distress syndrome and death .A male died at 15 years of age of unknown reasons .A patient age 15 years died of terminal liver failure and cardiac failure .A patent age 11 years died of unknown causes .A boy age eight years with prolidase | [
-0.11000277101993561,
0.056907352060079575,
-0.004871174693107605,
-0.21789753437042236,
0.0430842824280262,
0.052382078021764755,
0.013914107345044613,
-0.051598675549030304,
-0.10502614080905914,
-0.14021305739879608,
0.12309318035840988,
0.12334224581718445,
0.16070543229579926,
-0.03167349472641945,
-0.0504697822034359,
0.13309183716773987,
0.11463461816310883,
-0.0331069678068161,
-0.038704708218574524,
0.036539774388074875,
0.09122709184885025,
-0.10403214395046234,
0.16088363528251648,
0.13952085375785828,
0.18980632722377777,
-0.012171495705842972,
0.07019857317209244,
-0.0617876797914505,
0.007487468887120485,
0.18082581460475922,
-0.0211313609033823,
-0.13230496644973755,
-0.05406472831964493,
-0.2626011371612549,
0.11525460332632065,
0.03848392516374588,
-0.13478092849254608,
-0.04310568794608116,
0.2429010272026062,
-0.003817483317106962,
-0.06942383199930191,
-0.10624231398105621,
-0.01766674779355526,
0.08282186090946198,
-0.04649463668465614,
-0.09391672164201736,
0.01682588830590248,
0.07261316478252411,
-0.1485079526901245,
0.16230113804340363,
0.19670090079307556,
-0.028350552543997765,
-0.09883849322795868,
-0.027401503175497055,
0.2068539410829544,
0.195421040058136,
0.04354076832532883,
-0.013442106544971466,
-0.16190144419670105,
0.018334439024329185,
0.049085840582847595,
0.006785418372601271,
-0.02954501286149025,
-0.28407958149909973,
0.2576718032360077,
0.09353964775800705,
-0.017728785052895546,
-0.1453128606081009,
-0.17434221506118774,
-0.037329405546188354,
0.37929919362068176,
-0.012213902547955513,
0.22183966636657715,
0.030252957716584206,
0.028522389009594917,
0.09040097147226334,
0.08781367540359497,
-0.13897225260734558,
-0.06545428186655045,
-0.10723970830440521,
-0.150653675198555,
0.09914680570363998,
-0.12356779724359512,
0.10944139957427979,
-0.05927041172981262,
0.20850282907485962,
0.3157643675804138,
0.05049613118171692,
0.10923642665147781,
0.07241328060626984,
-0.06144499406218529,
-0.18061937391757965,
0.03687193989753723,
-0.21571572124958038,
-0.03398916497826576,
-0.15849655866622925,
-0.10220121592283249,
-0.0019584018737077713,
-0.1194557249546051,
0.16830062866210938,
0.1667710244655609,
0.008730337023735046,
-0.0029893286991864443,
0.09943153709173203,
0.032165613025426865,
0.0628381073474884,
-0.2100803405046463,
-0.06516478955745697,
-0.056993477046489716,
0.1346612572669983,
0.18397974967956543,
-0.04568909481167793,
-0.06335164606571198,
0.039991263300180435,
-0.11235246807336807,
0.0413556806743145,
0.0802808329463005,
-0.041712790727615356,
0.05326453223824501,
-0.13188499212265015,
-0.00264556473121047,
0.08841554820537567,
0.00096115906490013,
-0.20413632690906525,
0.07865989953279495,
0.21180838346481323,
-0.027107054367661476,
0.1121177077293396,
0.16342882812023163,
-0.11878488957881927,
0.019400786608457565,
-0.022182190790772438,
-0.07342640310525894,
-0.20493875443935394,
-0.14373160898685455,
-0.10788124799728394,
-0.173151895403862,
-0.0675923228263855,
0.0705970972776413,
-0.12424959987401962,
-0.045948706567287445,
-0.017544740810990334,
0.15166455507278442,
0.2927887439727783,
-0.11162631213665009,
0.04734092578291893,
0.3870110809803009,
0.11041618883609772,
0.2033083587884903,
0.08601748943328857,
-0.01398604828864336,
-0.0867493525147438,
0.2890697121620178,
-0.02789447270333767,
-0.13983505964279175,
0.08984705060720444,
-0.06148160248994827,
-0.03508121520280838,
-0.168845996260643,
0.06840246170759201,
0.15823756158351898,
0.025816170498728752,
0.15309621393680573,
0.010897325351834297,
0.08941126614809036,
-0.03638900816440582,
-0.10829111188650131,
0.021189052611589432,
0.03536880761384964,
0.07650256901979446,
0.005769615061581135,
0.09174692630767822,
-0.10453713685274124,
-0.05237991735339165,
0.2532978653907776,
-0.12010227888822556,
-0.06598613411188126,
-0.0791645497083664,
-0.09087689965963364,
0.14718282222747803,
0.017919817939400673,
0.05027659982442856,
-0.1436869204044342,
0.037230826914310455,
0.09541957825422287,
-0.18658223748207092,
0.08481576293706894,
0.25968003273010254,
0.07176575809717178,
0.1469031423330307,
0.16560102999210358,
0.06659504771232605,
0.09243737161159515,
-0.1918705850839615,
0.1689434051513672,
-0.16249477863311768,
-0.005204021465033293,
0.05997708812355995,
-0.17575125396251678,
0.003236273070797324,
0.11857909709215164,
-0.28868740797042847,
0.10509427636861801,
-0.08416953682899475,
0.04662458598613739,
-0.012331544421613216,
-0.09443382918834686,
-0.008585539646446705,
-0.02655334584414959,
0.19536420702934265,
-0.017996011301875114,
0.027416057884693146,
0.034897513687610626,
0.25103759765625,
-0.1096501275897026,
0.011335862800478935,
-0.2435869574546814,
-0.030342549085617065,
-0.03395947813987732,
-0.14257769286632538,
-0.02598664164543152,
0.06944799423217773,
-0.06512849032878876,
-0.271071195602417,
0.055658165365457535,
-0.031238416209816933,
-0.006469793617725372,
-0.03756706416606903,
0.08953894674777985,
0.038965798914432526,
0.01322026364505291,
0.14456059038639069,
0.06858748942613602,
0.16286258399486542,
-0.16098648309707642,
-0.1107240691781044,
0.13910558819770813,
0.22806082665920258,
0.030931396409869194,
0.10822203755378723,
-0.2859690487384796,
0.028430862352252007,
0.07039646059274673,
-0.10529482364654541,
-0.09753453731536865,
0.06496234238147736,
-0.1626070886850357,
0.05821843817830086,
-0.0658513754606247,
0.0836072638630867,
-0.025107398629188538,
-0.10526379942893982,
0.0839332714676857,
-0.09735360741615295,
-0.46360155940055847,
-0.0307964775711298,
0.19275349378585815,
-0.08536173403263092,
0.10502448678016663,
-0.048011064529418945,
0.08925146609544754,
0.011217799969017506,
0.05165936425328255,
-0.0246528759598732,
0.008887598291039467,
0.03344264626502991,
-0.19800223410129547,
0.18695752322673798,
-0.17618152499198914,
-0.19945412874221802,
-0.07123397290706635,
0.05904481187462807,
0.13072262704372406,
0.1466166377067566,
-0.09229937195777893,
-0.03374414145946503,
-0.14561612904071808,
0.08815987408161163,
0.20585036277770996,
-0.013066383078694344,
0.022350721061229706,
0.030589304864406586,
-0.12958048284053802,
0.04042987897992134,
0.2788515090942383,
0.02333451807498932,
0.14023499190807343,
0.18844032287597656,
0.021388914436101913,
0.03876388818025589,
0.002674924209713936,
0.10991007089614868,
-0.21034036576747894,
-0.01480073481798172,
0.11152613908052444,
0.0524689219892025,
-0.16611598432064056,
-0.14054296910762787,
0.10022890567779541,
0.025549767538905144,
0.08689939975738525,
0.25482359528541565,
0.007330082822591066,
-0.07081940770149231,
-0.15775761008262634,
-0.0515734888613224,
0.06672748178243637,
0.08235480636358261,
-0.08078375458717346,
0.16169390082359314,
-0.1668994128704071,
-0.08355772495269775,
-0.058754660189151764,
-0.15195947885513306,
0.05267053470015526,
0.053798381239175797,
-0.24540124833583832,
0.1277252435684204,
0.15098540484905243,
0.06399557739496231,
0.2013595998287201,
-0.029920315369963646,
0.11827896535396576,
0.17849312722682953,
-0.0051240636967122555,
0.05144363269209862,
-0.08171221613883972,
0.006771211978048086,
0.12492087483406067,
-0.00686390046030283,
-0.005853332579135895,
-0.01347120851278305,
0.09965330362319946,
0.002800075802952051,
0.006570261903107166,
0.03187459334731102,
0.14436326920986176,
-0.12989720702171326,
-0.0664963349699974,
-0.05189068987965584,
0.0683106854557991,
-0.060706742107868195,
0.02908291295170784,
-0.09649309515953064,
-0.1375274956226349,
-0.023170873522758484,
0.026342542842030525,
0.027061769738793373,
0.17243261635303497,
-0.01863276958465576,
-0.06216133013367653,
-0.11699019372463226,
-0.0047023058868944645,
-0.16037224233150482,
0.15673673152923584,
0.1592303216457367,
-0.16407476365566254,
0.012152445502579212,
0.10920386761426926,
-0.1738433986902237,
-0.09721836447715759,
0.23980198800563812,
0.33910655975341797,
-0.1462443619966507,
0.321940153837204,
0.03496426343917847,
0.16042213141918182,
-0.01761411689221859,
0.04552174359560013,
-0.13089093565940857,
-0.07838478684425354,
-0.07368575036525726,
0.14855130016803741,
0.08681990206241608,
-0.13319925963878632,
0.16248619556427002,
-0.16807320713996887,
0.18933075666427612,
-0.14090853929519653,
0.0740169957280159,
-0.14440542459487915,
0.1346484273672104,
0.23746389150619507,
0.22418704628944397,
0.14854487776756287,
-0.036475926637649536,
-0.07755973190069199,
0.029915980994701385,
0.06905180215835571,
-0.11075564473867416,
0.1316201090812683,
0.2731567621231079,
-0.003954469691962004,
0.13261477649211884,
-0.20655982196331024,
0.1278052181005478,
-0.05709598958492279,
-0.10767380893230438,
-0.25336360931396484,
0.03897726535797119,
-0.09481041133403778,
-0.011752343736588955,
0.051846589893102646,
0.21646301448345184,
0.07051064074039459,
0.2004830688238144,
0.08428063988685608,
0.10718505829572678,
0.005726311821490526,
-0.10977248847484589,
-0.024832427501678467,
0.004583405796438456,
-0.036675337702035904,
-0.2124881148338318,
0.07111196964979172,
0.009442354552447796,
-0.01650683768093586,
0.11155319958925247,
0.1549476534128189,
0.024959582835435867,
-0.1576312780380249,
-0.16524116694927216,
0.2073872685432434,
-0.016756484284996986,
-0.09325206279754639,
0.08327516913414001,
0.06282175332307816,
-0.026600578799843788,
0.08491974323987961,
0.21597854793071747,
0.13405948877334595,
0.1793534755706787,
0.000986521947197616,
-0.11256326735019684,
0.2786180078983307,
-0.0013106275582686067,
0.035831745713949203,
0.1757635474205017,
0.07368580251932144,
0.057156775146722794,
0.17504966259002686,
0.2214277684688568,
-0.10112370550632477,
0.004693756811320782,
-0.08027365058660507,
0.07971581816673279,
0.08511330932378769,
0.1321089118719101,
0.23884788155555725,
0.19042621552944183,
-0.034446682780981064,
-0.1046142503619194,
-0.011022195219993591,
0.005611924920231104,
-0.1726195365190506,
0.09794460237026215,
-0.14793390035629272,
-0.06824512034654617,
0.060850948095321655,
0.07697926461696625,
-0.029696563258767128,
0.21467556059360504,
0.046727750450372696,
-0.15839813649654388,
-0.08957850188016891,
0.17007501423358917,
-0.2119770497083664,
0.03568657115101814,
-0.11043182015419006,
0.04890131205320358,
0.09337568283081055,
0.08147051185369492,
-0.04577498510479927,
-0.07903861999511719,
-0.1752794235944748,
0.02281980961561203,
-0.06972213834524155,
0.04322339966893196,
-0.10579939931631088,
0.07331126183271408,
-0.07101738452911377,
-0.0351455882191658,
-0.13550592958927155,
-0.07541896402835846,
0.041085708886384964,
-0.13526080548763275,
-0.0008550890488550067,
-0.10731092840433121,
0.1623481959104538,
0.0918460264801979,
0.05904936417937279,
0.029460905119776726,
0.10640616714954376,
0.3147987127304077,
0.06049971282482147,
-0.06710108369588852,
-0.07894351333379745,
-0.1680193394422531,
0.0959707722067833,
-0.015266967006027699,
-0.04115382209420204,
-0.027032887563109398,
0.04607510566711426,
0.31239649653434753,
0.02420397475361824,
-0.08194144815206528,
0.014670701697468758,
-0.025159146636724472,
0.11747273802757263,
0.26227572560310364,
0.17948441207408905,
-0.04690233990550041,
-0.18280628323554993,
-0.019154302775859833,
-0.09329146146774292,
-0.10720521211624146,
0.16060619056224823,
0.1500926911830902,
0.19578976929187775,
-0.06783860176801682,
0.1450290083885193,
-0.16528020799160004,
0.047780975699424744,
0.1500316709280014,
-0.06274504959583282,
-0.2229519784450531,
-0.03868134692311287,
0.03305729851126671,
-0.2535742223262787,
-0.19054090976715088,
-0.022382142022252083,
-0.11309649050235748,
-0.02392352744936943,
0.11733793467283249,
0.07848070561885834,
-0.07418159395456314,
-0.004966431297361851,
-0.009776412509381771,
0.05041506886482239,
0.01616855338215828,
0.14781063795089722,
-0.08052767813205719,
0.003793940180912614,
0.03645239770412445,
-0.2359100580215454,
0.19083765149116516,
0.03877256438136101,
-0.05489896610379219,
-0.012153204530477524,
0.0469847172498703,
0.04037577286362648,
0.18136698007583618,
0.057532377541065216,
0.04893485829234123,
-0.09520207345485687,
-0.013024951331317425,
0.05895474925637245,
-0.10935897380113602,
-0.05029337853193283,
0.04259708896279335,
-0.0899401530623436,
-0.11872923374176025,
-0.045892223715782166,
-0.13716788589954376,
-0.003247971646487713,
0.10875797271728516,
-0.07663734257221222,
0.03022213838994503,
-0.009886587969958782,
-0.21831075847148895,
-0.03054657392203808,
-0.12994635105133057,
-0.022659368813037872,
-0.24034418165683746,
-0.27009591460227966,
0.07978786528110504,
-0.15592563152313232,
-0.10168300569057465,
-0.1173512265086174,
0.01481554377824068,
-0.09757906198501587,
-0.17593121528625488,
-0.023658467456698418,
0.14535385370254517,
-0.012812905013561249,
0.11112881451845169,
-0.010846399702131748,
0.059335123747587204,
0.06608288735151291,
-0.020213505253195763,
0.12781651318073273,
-0.176773801445961,
-0.12032539397478104,
-0.13403989374637604,
0.16056279838085175,
0.03135091811418533,
0.11378533393144608,
-0.28300702571868896,
0.03479114919900894,
-0.09936115890741348,
-0.0869576707482338,
0.22149856388568878,
-0.06820275634527206,
-0.12062012404203415,
-0.021907035261392593,
0.08799199759960175,
0.08219218254089355,
-0.2423161417245865,
0.1516542285680771,
0.05971873551607132,
0.12188075482845306,
-0.07349452376365662,
0.1415480226278305,
0.04559757187962532,
0.2076949030160904,
-0.053495388478040695,
-0.016689039766788483,
-0.2733721435070038,
-0.0049629067070782185,
-0.15353082120418549,
0.19227398931980133,
0.14730295538902283,
0.1541106104850769,
-0.222730353474617,
-0.06809676438570023,
0.14229156076908112,
-0.023457199335098267,
-0.06810157746076584,
0.06871511042118073,
0.1202966645359993,
-0.10250120609998703,
-0.10086830705404282,
0.03959277644753456,
0.16870006918907166,
-0.15366317331790924,
0.12414256483316422,
0.033423978835344315,
0.3902333676815033,
-0.011879442259669304,
-0.08544851094484329,
-0.1651804894208908,
-0.04301837459206581,
-0.1018235832452774,
0.1005653589963913,
-0.08367188274860382,
0.2860201299190521,
-0.05677066743373871,
0.06889326870441437,
0.1634366363286972,
-0.06086169183254242,
0.18724629282951355,
-0.03730231150984764,
-0.11041216552257538,
0.1579681932926178,
0.020666878670454025,
0.04827257990837097,
0.086146779358387,
-0.006430193316191435,
0.11816498637199402,
-0.15569859743118286,
0.12817694246768951,
0.0034912775736302137,
-0.1581319123506546,
-0.022220833227038383,
-0.010277952998876572,
0.06612502038478851,
0.13821688294410706,
-0.00006606705574085936,
-0.004077587742358446,
0.06196998804807663,
0.12834113836288452,
0.1853429079055786,
-0.22029300034046173,
0.05176888406276703,
0.05092071369290352,
-0.041916146874427795,
-0.15428870916366577,
-0.08561130613088608,
-0.0550806000828743,
0.21500398218631744,
-0.024398397654294968,
-0.2991725206375122,
-0.0007738438434898853,
-0.09118574112653732,
-0.0006447662017308176,
0.07348786294460297,
-0.0486944280564785,
0.009070884436368942,
0.3444637656211853,
-0.022448446601629257,
-0.1730962097644806,
-0.07414846867322922,
0.10664382576942444,
0.17518778145313263,
-0.010676519945263863,
-0.11664409190416336,
0.1759314239025116,
0.13384293019771576,
-0.018765678629279137,
-0.07542974501848221,
0.027616553008556366,
0.07902488112449646,
-0.08305741846561432,
0.158554345369339,
0.0903642326593399,
0.09230325371026993,
0.1374773383140564,
-0.17026139795780182,
-0.07548891007900238,
0.08705023676156998,
-0.11155141144990921,
-0.10631627589464188,
-0.07986588031053543,
0.030712950974702835,
0.06583435833454132,
0.21130764484405518,
-0.19181586802005768,
-0.010211696848273277,
-0.019604843109846115,
0.13252590596675873,
0.020700357854366302,
0.004571350757032633,
-0.027211088687181473,
-0.08162698894739151,
0.05122050642967224,
0.017076551914215088,
-0.0673387423157692,
-0.09019915759563446,
0.12673397362232208,
-0.13617540895938873,
-0.14518214762210846,
-0.08984442800283432,
-0.04848143085837364,
0.24455346167087555,
-0.028944484889507294,
0.12973375618457794,
0.14541751146316528,
-0.020251231268048286,
-0.015291556715965271,
0.21817335486412048,
0.006126559339463711,
0.02514091320335865,
0.031014584004878998,
-0.021685155108571053,
0.16542844474315643,
0.19549642503261566,
-0.20831069350242615,
0.0072365812957286835,
-0.11735108494758606,
-0.14313733577728271,
0.06992878019809723,
0.1313159167766571,
-0.04925842955708504,
0.026142099872231483,
0.04914920777082443,
0.05006951093673706,
-0.05758853256702423,
-0.09422223269939423,
0.11080334335565567,
0.09046832472085953,
-0.18933901190757751,
-0.11376664787530899,
0.01685314252972603,
0.03822759538888931,
0.007289687171578407,
-0.04741809144616127,
-0.05685335770249367,
0.11978522688150406
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. infection of skin ulcers with Pseudomonas aeruginosa, which lead to septic shock and disseminated intravascular coagulation .A female died of a fungal infection and disseminated intravascular coagulation .A girl age 16 years with prolidase deficiency and SLE developed cellulitis of the leg, followed by adult respiratory distress syndrome and death .A male died at 15 years of age of unknown reasons .A patient age 15 years died of terminal liver failure and cardiac failure .A patent age 11 years died of unknown causes .A boy age eight years with prolidase deficiency and SLE died after developing a facial abscess and septicemia .The youngest reported death was at age four years .Genotype-Phenotype CorrelationsThere are no known genotype-phenotype correlations. Marked phenotypic variability has been found among affected individuals from the same family (who have the same pathogenic variants) .NomenclatureProlidase deficiency was also known as hyperimidodipeptiduria, although increased excretion of imidodipeptides is not exclusive to prolidase deficiency. Other | [
-0.13694320619106293,
0.14689324796199799,
-0.00741760665550828,
-0.18651968240737915,
0.10373110324144363,
0.15046806633472443,
0.013581258244812489,
-0.02401670441031456,
-0.0454043410718441,
-0.16414982080459595,
0.14574110507965088,
0.12769091129302979,
0.17889414727687836,
-0.0853760689496994,
-0.12688525021076202,
0.13600535690784454,
0.13105833530426025,
0.03559718281030655,
-0.06313683092594147,
-0.00962432473897934,
0.07327732443809509,
-0.07503736764192581,
0.10865838825702667,
0.14960545301437378,
0.18816938996315002,
-0.03206213563680649,
0.11687217652797699,
0.016705157235264778,
-0.013833843171596527,
0.09285955876111984,
-0.00045318130287341774,
-0.08040039986371994,
-0.0470837764441967,
-0.22816523909568787,
0.09327075630426407,
0.05957717075943947,
-0.15761739015579224,
-0.00776217645034194,
0.11382738500833511,
-0.04615508019924164,
-0.05877308174967766,
-0.052821848541498184,
-0.031250450760126114,
0.08850213140249252,
-0.035488568246364594,
-0.02019330859184265,
-0.048562753945589066,
0.08390264958143234,
-0.10468551516532898,
0.1323632299900055,
0.22468218207359314,
-0.09482204914093018,
-0.00026542891282588243,
-0.028030600398778915,
0.2389472872018814,
0.043300315737724304,
0.08898746967315674,
0.007828857749700546,
-0.09966528415679932,
-0.04708947613835335,
0.08178345859050751,
-0.004657599609345198,
-0.02139820158481598,
-0.3122047483921051,
0.24042752385139465,
0.03263381868600845,
0.04631288722157478,
-0.14214839041233063,
-0.1929631382226944,
-0.07379148155450821,
0.4729241132736206,
0.029000110924243927,
0.26312804222106934,
-0.026598740369081497,
-0.022056661546230316,
0.0002269645920023322,
0.08608856797218323,
-0.07137755304574966,
0.0008378825732506812,
-0.1446666419506073,
-0.14007963240146637,
0.15545333921909332,
-0.010176870971918106,
0.16539157927036285,
-0.07453836500644684,
0.2668021023273468,
0.15814772248268127,
0.12351571023464203,
0.06707116961479187,
0.03995116800069809,
0.015551949851214886,
-0.2327548712491989,
0.10895918309688568,
-0.1805044710636139,
0.015355578623712063,
-0.11337291449308395,
-0.10972095280885696,
0.07877544313669205,
-0.12489315867424011,
0.15081706643104553,
0.14051304757595062,
0.03777356073260307,
-0.04938754811882973,
0.03351553902029991,
0.05565115809440613,
-0.037497591227293015,
-0.16103890538215637,
-0.07453811913728714,
-0.08389673382043839,
0.0877809002995491,
0.09563977271318436,
-0.03971170634031296,
-0.08197395503520966,
0.019796190783381462,
-0.1763972043991089,
0.001197321224026382,
0.04829879105091095,
-0.032955102622509,
-0.05732738599181175,
-0.10010141134262085,
-0.047017939388751984,
0.04242769628763199,
-0.008925817906856537,
-0.18982762098312378,
0.1715914011001587,
0.16046784818172455,
0.014176201075315475,
0.06139710173010826,
0.178362175822258,
-0.08701976388692856,
0.06583647429943085,
-0.10343016684055328,
-0.016645103693008423,
-0.24509823322296143,
-0.07144974917173386,
-0.07120377570390701,
-0.14595647156238556,
-0.1429537832736969,
-0.03922257944941521,
-0.04942203313112259,
-0.021454723551869392,
0.039997875690460205,
0.19295598566532135,
0.3016503155231476,
-0.10764123499393463,
0.09790945798158646,
0.38954752683639526,
0.06896394491195679,
0.16262699663639069,
0.030015332624316216,
0.03981340304017067,
-0.10993870347738266,
0.2908344864845276,
-0.021914100274443626,
-0.06690344959497452,
0.13218261301517487,
-0.13070222735404968,
0.05726272240281105,
-0.1813388168811798,
0.10920947045087814,
0.12533727288246155,
-0.03106372430920601,
0.18097536265850067,
-0.17333285510540009,
0.11646609753370285,
-0.005208747927099466,
-0.06009935960173607,
-0.030824242159724236,
0.04827079549431801,
0.09061484038829803,
-0.023858843371272087,
-0.005617670249193907,
-0.06772587448358536,
0.07929076999425888,
0.1987835317850113,
-0.1265069991350174,
-0.010112007148563862,
-0.0078062755055725574,
-0.11989021301269531,
0.2047116458415985,
-0.007366009522229433,
-0.026675114408135414,
-0.17027655243873596,
-0.011858378536999226,
-0.048116035759449005,
-0.18460729718208313,
0.01748731918632984,
0.28388941287994385,
0.11587074398994446,
0.11134593188762665,
0.12749464809894562,
0.08690553903579712,
-0.05933713912963867,
-0.147281214594841,
0.10224529355764389,
-0.1831681728363037,
0.034360047429800034,
-0.09737760573625565,
-0.1837739795446396,
0.037580009549856186,
0.06948654353618622,
-0.23941631615161896,
0.1451544463634491,
-0.08072793483734131,
0.05180024355649948,
0.008150020614266396,
-0.08446484804153442,
0.04848518222570419,
-0.01986413262784481,
0.3092719316482544,
-0.042108673602342606,
0.08687982708215714,
-0.07817362248897552,
0.2369547039270401,
-0.08099722862243652,
-0.013469438068568707,
-0.2744658291339874,
0.01892566867172718,
-0.02062239684164524,
-0.028819575905799866,
-0.08390666544437408,
-0.10480345785617828,
-0.07633719593286514,
-0.28579241037368774,
0.09045438468456268,
-0.01892344281077385,
-0.07327388972043991,
0.04341534525156021,
0.11016615480184555,
-0.0030480672139674425,
-0.04037588834762573,
0.1621909886598587,
0.19723379611968994,
0.23602308332920074,
-0.17026790976524353,
-0.12978188693523407,
0.030000394210219383,
0.23742197453975677,
0.051664117723703384,
0.1021016389131546,
-0.22675345838069916,
0.033208370208740234,
0.09909407049417496,
-0.034462153911590576,
-0.11748386919498444,
0.0961480513215065,
-0.12580929696559906,
0.04439595341682434,
-0.04836282134056091,
0.10648483037948608,
-0.07420748472213745,
-0.07864133268594742,
0.11406470090150833,
-0.08381188660860062,
-0.435282826423645,
-0.003692460944876075,
0.07446818053722382,
-0.0829513818025589,
0.11217351257801056,
0.06785765290260315,
0.05124084651470184,
-0.0006870872457511723,
0.10975953936576843,
0.016833795234560966,
0.03143739327788353,
0.0577138252556324,
-0.13921605050563812,
0.16391471028327942,
-0.12813840806484222,
-0.2903406322002411,
-0.05419550836086273,
0.0286030825227499,
0.2048027366399765,
0.09338102489709854,
-0.04633038118481636,
-0.06973233819007874,
-0.17942193150520325,
0.039932165294885635,
0.1827668398618698,
-0.1499728113412857,
0.08873461931943893,
0.051612213253974915,
-0.14054864645004272,
-0.0010737825650721788,
0.1961350291967392,
0.12094061821699142,
0.06051770597696304,
0.270498126745224,
-0.0055103302001953125,
0.09108485281467438,
0.10586303472518921,
0.19695140421390533,
-0.13245001435279846,
-0.016533346846699715,
0.0033735083416104317,
0.07775651663541794,
-0.1361052393913269,
-0.10142333060503006,
0.10830019414424896,
0.02787431702017784,
0.1449953317642212,
0.15222668647766113,
-0.016661901026964188,
-0.16572202742099762,
-0.09919607639312744,
-0.08861365169286728,
0.08091440796852112,
0.09982691705226898,
-0.0945156067609787,
0.16725051403045654,
-0.14549562335014343,
-0.12052473425865173,
-0.026176469400525093,
-0.12468266487121582,
0.03775279223918915,
0.006784223951399326,
-0.2786877453327179,
0.0055581978522241116,
0.057157211005687714,
0.11952756345272064,
0.21087396144866943,
-0.08821136504411697,
0.08950779587030411,
0.16300268471240997,
-0.07862496376037598,
0.023408053442835808,
-0.17656992375850677,
-0.06399161368608475,
-0.0032013405580073595,
-0.0496438629925251,
-0.007691461127251387,
0.04611625894904137,
0.153716042637825,
-0.0784551128745079,
0.05530891939997673,
0.02581016905605793,
0.21637383103370667,
-0.1172659695148468,
-0.05879365652799606,
-0.04319745674729347,
0.07780199497938156,
-0.16791506111621857,
0.042968958616256714,
-0.1300373524427414,
-0.18940898776054382,
0.0007332642562687397,
0.03929045423865318,
0.09287998080253601,
0.21451878547668457,
-0.05141040310263634,
-0.09265631437301636,
-0.09396794438362122,
-0.04482044279575348,
-0.1777842938899994,
0.16612648963928223,
0.1455012857913971,
-0.14111684262752533,
0.015838054940104485,
0.24841226637363434,
-0.10754694789648056,
-0.13717694580554962,
0.23036867380142212,
0.3066120147705078,
-0.14315301179885864,
0.3452793061733246,
0.15530706942081451,
0.11140546947717667,
-0.07907284796237946,
0.07150810956954956,
-0.10987276583909988,
-0.011708343401551247,
0.001963460585102439,
0.21451181173324585,
0.10827385634183884,
-0.0714716762304306,
0.16439062356948853,
-0.2075289487838745,
0.19459979236125946,
-0.10675743222236633,
-0.025408947840332985,
-0.09936218708753586,
0.0977623388171196,
0.18929120898246765,
0.2165040373802185,
0.10259779542684555,
0.05837400630116463,
-0.11660262197256088,
0.018590359017252922,
0.02635110914707184,
-0.1046009510755539,
0.2211574912071228,
0.19399775564670563,
-0.010204632766544819,
0.07197485119104385,
-0.2579551637172699,
0.10993730276823044,
-0.037365831434726715,
-0.10676176846027374,
-0.22267648577690125,
0.04377980902791023,
-0.006137187127023935,
-0.0256100594997406,
0.1442776769399643,
0.16952404379844666,
0.179407998919487,
0.1814764142036438,
-0.009322152473032475,
0.1033162847161293,
0.0693226307630539,
-0.08047225326299667,
0.057511426508426666,
-0.008826671168208122,
-0.07061515003442764,
-0.24328289926052094,
0.02581804431974888,
0.04764820635318756,
-0.07688868790864944,
0.16363127529621124,
0.1879458725452423,
-0.04497363045811653,
-0.11102195084095001,
-0.2029106765985489,
0.1697743833065033,
-0.04034287855029106,
-0.044525064527988434,
-0.03815046697854996,
0.023661240935325623,
-0.007431020028889179,
0.15000797808170319,
0.27157872915267944,
0.18551410734653473,
0.157413512468338,
-0.011143678799271584,
0.00807340256869793,
0.2293550968170166,
-0.07275141775608063,
0.040691375732421875,
0.1068459078669548,
0.19019056856632233,
0.03407176584005356,
0.3053213655948639,
0.030504491180181503,
-0.15434080362319946,
-0.06240750476717949,
-0.1301504522562027,
0.16567930579185486,
-0.016885537654161453,
0.11698878556489944,
0.1919839233160019,
0.1754325032234192,
0.039289575070142746,
-0.12154064327478409,
0.01912980154156685,
-0.0730498880147934,
-0.16191276907920837,
0.0786922350525856,
-0.11970150470733643,
-0.07455272227525711,
0.05164283141493797,
0.1084151417016983,
-0.05426459014415741,
0.2348438799381256,
-0.01915937289595604,
-0.17240391671657562,
0.004124774597585201,
0.23308086395263672,
-0.2755357623100281,
0.07699761539697647,
-0.014929166063666344,
0.08110936731100082,
0.0964590311050415,
0.08100636303424835,
0.038387175649404526,
-0.03670317307114601,
-0.1067715659737587,
-0.07438824325799942,
-0.014661767520010471,
0.09221108257770538,
-0.1493869125843048,
0.13776303827762604,
-0.04176551103591919,
0.03819306939840317,
-0.1767173707485199,
-0.042393747717142105,
0.03959989547729492,
-0.13668958842754364,
-0.02717071771621704,
-0.09756270051002502,
0.10838913172483444,
0.10268539190292358,
0.07306095957756042,
0.10885197669267654,
0.04396995157003403,
0.2879398465156555,
0.09308229386806488,
-0.005655842833220959,
-0.068024642765522,
-0.231950044631958,
0.07589410245418549,
-0.07952436804771423,
0.030685056000947952,
-0.1502629965543747,
0.03683770075440407,
0.32666391134262085,
0.10746008157730103,
-0.1379273682832718,
0.02725060284137726,
0.0026349779218435287,
0.0764617994427681,
0.24763959646224976,
0.2203691601753235,
-0.0766008123755455,
-0.17676542699337006,
-0.02472575381398201,
-0.16428957879543304,
-0.08074738085269928,
0.1331050843000412,
0.09980971366167068,
0.20047926902770996,
-0.07898849248886108,
0.09898628294467926,
-0.10893788188695908,
0.09068752080202103,
0.20092685520648956,
-0.09333746135234833,
-0.2020878791809082,
0.00858326070010662,
-0.01752166822552681,
-0.2111038714647293,
-0.23857390880584717,
-0.019955679774284363,
-0.11840170621871948,
-0.00725959986448288,
0.0931219682097435,
0.10132038593292236,
-0.005699404515326023,
-0.06272027641534805,
-0.06562540680170059,
0.061293825507164,
0.03954075276851654,
0.08141723275184631,
0.04163285717368126,
-0.02258182130753994,
0.04419668763875961,
-0.2214600294828415,
0.15462225675582886,
-0.024575941264629364,
-0.09553120285272598,
0.04179607331752777,
0.11601866781711578,
0.0689348354935646,
0.15716060996055603,
0.06496482342481613,
0.04455799236893654,
-0.040179576724767685,
-0.012012148275971413,
0.03036593273282051,
-0.07896502315998077,
-0.09169088304042816,
-0.02050301432609558,
-0.030745742842555046,
-0.05090436339378357,
-0.060287706553936005,
-0.0897592306137085,
-0.043457046151161194,
0.1496928185224533,
-0.11439520865678787,
0.04975142329931259,
-0.12253139168024063,
-0.11225666850805283,
-0.10935350507497787,
-0.08575218915939331,
0.027626603841781616,
-0.20004834234714508,
-0.19008353352546692,
0.029047518968582153,
-0.1621672511100769,
-0.10006936639547348,
-0.13283802568912506,
0.04658275097608566,
-0.06841808557510376,
-0.13905645906925201,
0.05576542019844055,
0.14046712219715118,
-0.013704448007047176,
0.03827308118343353,
-0.08786565065383911,
0.1199776753783226,
0.057635389268398285,
-0.05940360575914383,
0.19211100041866302,
-0.1326681673526764,
-0.14108629524707794,
-0.17779716849327087,
0.14709077775478363,
0.0730009451508522,
0.13715213537216187,
-0.2680189907550812,
0.0011339737102389336,
-0.1251249611377716,
-0.07461174577474594,
0.15768130123615265,
-0.0851287767291069,
-0.2135799676179886,
-0.08999854326248169,
0.038280025124549866,
0.0873066708445549,
-0.23838548362255096,
0.21305404603481293,
0.013762167654931545,
0.1636212170124054,
-0.07294562458992004,
0.13643565773963928,
0.06742440164089203,
0.24249736964702606,
-0.06428835541009903,
-0.06503277271986008,
-0.2926499843597412,
0.03195535019040108,
-0.1507318615913391,
0.17803795635700226,
0.13370221853256226,
0.15874560177326202,
-0.20771455764770508,
-0.09124904870986938,
0.1468012034893036,
0.05570121109485626,
-0.01732894778251648,
0.05649345740675926,
0.05222754180431366,
-0.04987090826034546,
-0.0643944963812828,
-0.03246905654668808,
0.09490896016359329,
-0.15666207671165466,
0.0975559875369072,
0.04180430248379707,
0.43294820189476013,
-0.005063727963715792,
-0.032710470259189606,
-0.09688795357942581,
-0.0958210900425911,
-0.14418014883995056,
0.17092038691043854,
-0.08828139305114746,
0.3167153000831604,
-0.09090183675289154,
0.040568117052316666,
0.16319534182548523,
-0.10578369349241257,
0.10604480654001236,
-0.008335564285516739,
-0.06253683567047119,
0.07684741914272308,
0.0040849922224879265,
0.004427472595125437,
0.08611670136451721,
0.006487767677754164,
0.11782154440879822,
-0.2047138214111328,
0.19303718209266663,
-0.0636461153626442,
-0.13740873336791992,
-0.024015551432967186,
-0.029176365584135056,
0.04418114200234413,
0.17519719898700714,
-0.051359932869672775,
-0.05044354498386383,
-0.09342765808105469,
0.12218653410673141,
0.19993887841701508,
-0.12201136350631714,
0.047546446323394775,
0.09075149893760681,
-0.05525743588805199,
-0.10440535843372345,
-0.16220882534980774,
-0.11800907552242279,
0.2184600979089737,
-0.01270714309066534,
-0.2489805966615677,
-0.13725388050079346,
-0.11908984184265137,
0.06562376767396927,
0.09546476602554321,
0.003784527536481619,
-0.06803080439567566,
0.30590254068374634,
-0.07809682190418243,
-0.11046446114778519,
-0.07180042564868927,
0.054679322987794876,
0.12485579401254654,
-0.012560124509036541,
-0.11656176298856735,
0.25163525342941284,
0.15735216438770294,
0.1203996017575264,
-0.1332535296678543,
0.06304953992366791,
0.04846984148025513,
-0.06271768361330032,
0.15763628482818604,
0.16581949591636658,
0.11184227466583252,
0.13530053198337555,
-0.10775189101696014,
-0.09753318876028061,
-0.02681821770966053,
-0.015518912114202976,
-0.08158045262098312,
-0.07714527100324631,
0.09371476620435715,
0.08351131528615952,
0.16377069056034088,
-0.18801917135715485,
-0.1441771537065506,
-0.07003004848957062,
0.09933321923017502,
-0.007481961045414209,
0.028983790427446365,
-0.0062209866009652615,
-0.08949460089206696,
-0.05660253390669823,
0.04105237126350403,
-0.08698815107345581,
-0.010097854770720005,
0.1902569979429245,
-0.12850557267665863,
-0.21677064895629883,
-0.0715179368853569,
-0.0599588006734848,
0.23262247443199158,
-0.07262415438890457,
0.08230635523796082,
0.09408898651599884,
-0.04473453015089035,
-0.0499286912381649,
0.12755164504051208,
-0.02163640968501568,
0.09179774671792984,
-0.036453977227211,
0.02721044048666954,
0.13804428279399872,
0.11445925384759903,
-0.20161865651607513,
0.01916012167930603,
-0.12794193625450134,
-0.12223165482282639,
-0.014581467024981976,
0.10526445508003235,
0.015531833283603191,
0.09958955645561218,
0.01669755019247532,
0.07789532095193863,
-0.08922160416841507,
-0.19698292016983032,
0.0883740782737732,
0.06093090400099754,
-0.12733249366283417,
-0.13223056495189667,
-0.008791557513177395,
-0.0480116568505764,
-0.011657156981527805,
-0.033266134560108185,
-0.0024414840154349804,
0.05695071816444397
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. age eight years with prolidase deficiency and SLE died after developing a facial abscess and septicemia .The youngest reported death was at age four years .Genotype-Phenotype CorrelationsThere are no known genotype-phenotype correlations. Marked phenotypic variability has been found among affected individuals from the same family (who have the same pathogenic variants) .NomenclatureProlidase deficiency was also known as hyperimidodipeptiduria, although increased excretion of imidodipeptides is not exclusive to prolidase deficiency. Other names used in the past include imidodipeptidase deficiency and peptidase D deficiency.PrevalenceApproximately 90 affected individuals have been reported in the literature; however, prolidase deficiency likely remains underdiagnosed as a result of under-recognition by physicians.The Québec Newborn Urine Screening Program (Programme québécois de dépistage neonatal Urinaire, PQDNU) identified two affected infants out of 2,469,929 screened between 1973 and 2006, | [
-0.103254035115242,
0.19733992218971252,
-0.07419504970312119,
-0.1271747350692749,
0.15299740433692932,
0.25798043608665466,
0.024992862716317177,
-0.0957852229475975,
0.11577567458152771,
-0.036143139004707336,
0.14595188200473785,
0.1742101013660431,
0.07885131239891052,
-0.030214209109544754,
-0.21223723888397217,
0.09592103213071823,
0.19374874234199524,
-0.0647406280040741,
-0.026008106768131256,
-0.02056211419403553,
0.009838763624429703,
-0.026026416569948196,
0.16061431169509888,
0.16978679597377777,
0.2787013351917267,
-0.012088733725249767,
0.030028462409973145,
0.029747692868113518,
0.05414434149861336,
-0.050991032272577286,
-0.020106906071305275,
0.05201574042439461,
-0.04334302991628647,
-0.1385471075773239,
0.12840059399604797,
0.02696421556174755,
-0.13275030255317688,
0.06272371113300323,
0.09066783636808395,
-0.11176886409521103,
-0.12913896143436432,
-0.04076206684112549,
0.06060587242245674,
0.12959499657154083,
-0.027565576136112213,
0.1380888968706131,
-0.10807030647993088,
0.1479092389345169,
-0.1568288505077362,
0.1091463565826416,
0.22052782773971558,
-0.06251178681850433,
-0.02371249720454216,
-0.06409153342247009,
0.17493829131126404,
0.025739116594195366,
0.1435345560312271,
0.11709095537662506,
-0.14848974347114563,
-0.05924338102340698,
0.06856217235326767,
-0.15984269976615906,
0.019285501912236214,
-0.3811720907688141,
0.11105301231145859,
-0.04521831125020981,
0.1866394728422165,
-0.1665995866060257,
-0.13300475478172302,
-0.15493516623973846,
0.43244779109954834,
0.019608832895755768,
0.30492499470710754,
0.03161622956395149,
-0.15270939469337463,
-0.02161785215139389,
0.07598092406988144,
0.02306094579398632,
0.002883258508518338,
-0.12331952154636383,
-0.2672067880630493,
0.23682090640068054,
0.042983874678611755,
0.18798421323299408,
-0.15342804789543152,
0.32243555784225464,
0.11653909087181091,
0.21044735610485077,
0.13820506632328033,
0.00610472122207284,
0.1661836951971054,
-0.29692673683166504,
0.1862759292125702,
-0.18629711866378784,
-0.006859492510557175,
-0.2249523401260376,
-0.09899090975522995,
0.1582038551568985,
-0.17961056530475616,
0.14976893365383148,
0.061648838222026825,
0.1232137605547905,
-0.033552419394254684,
0.0036760084331035614,
0.16436605155467987,
-0.023497020825743675,
-0.09092032164335251,
-0.16254819929599762,
-0.04194338619709015,
-0.07567920535802841,
-0.015187743119895458,
-0.07924561202526093,
-0.125064417719841,
0.041116777807474136,
-0.2347766011953354,
-0.08519595116376877,
0.2948576807975769,
-0.154235377907753,
-0.1414385885000229,
-0.15968263149261475,
-0.010815095156431198,
0.1397435963153839,
0.01658543571829796,
-0.17990104854106903,
0.27545225620269775,
0.16978837549686432,
0.12075092643499374,
0.07363365590572357,
0.17296722531318665,
-0.09140205383300781,
0.11204738914966583,
-0.06862766295671463,
-0.008280708454549313,
-0.22414445877075195,
-0.1264234036207199,
0.07526163011789322,
-0.2051525115966797,
-0.119171142578125,
-0.03260732442140579,
0.0710010752081871,
0.030655954033136368,
0.026630641892552376,
0.1557220220565796,
0.22631609439849854,
-0.051074475049972534,
0.19096428155899048,
0.3863914906978607,
-0.06690185517072678,
0.048348184674978256,
0.019090907648205757,
0.054319288581609726,
-0.030566217377781868,
0.2998477816581726,
0.04954371601343155,
0.009653554297983646,
0.10048660635948181,
-0.15879970788955688,
0.12641541659832,
-0.11916188895702362,
0.24443496763706207,
0.08186371624469757,
-0.05202644690871239,
0.1833852231502533,
-0.25503861904144287,
0.1107419952750206,
-0.03391702100634575,
-0.06945234537124634,
0.029979074373841286,
0.06471774727106094,
0.03436947241425514,
-0.0704183280467987,
-0.033714402467012405,
-0.08259646594524384,
0.16964374482631683,
0.1485569179058075,
-0.14367738366127014,
0.0028889747336506844,
0.029799750074744225,
-0.09353060275316238,
0.20386436581611633,
-0.013360394164919853,
-0.03669910505414009,
-0.05258670821785927,
0.058588653802871704,
-0.10610254853963852,
-0.1476723700761795,
-0.026465842500329018,
0.3164108693599701,
0.05826111137866974,
0.2626189589500427,
0.16598711907863617,
0.08384434133768082,
-0.11343112587928772,
-0.10001582652330399,
0.17965596914291382,
-0.24723577499389648,
0.13720057904720306,
-0.15555362403392792,
-0.1548018753528595,
0.04651012271642685,
0.08922217041254044,
-0.21195128560066223,
0.1749352514743805,
-0.07114699482917786,
0.12696123123168945,
0.015950240194797516,
-0.032489992678165436,
0.03379242122173309,
-0.10115227848291397,
0.4148648977279663,
-0.007935408502817154,
0.11262068152427673,
-0.18286214768886566,
0.2827995717525482,
-0.10101021826267242,
-0.015822334215044975,
-0.23588140308856964,
-0.02823728322982788,
-0.11942268908023834,
0.012328621000051498,
-0.0753914937376976,
-0.16606685519218445,
-0.08858741819858551,
-0.18922382593154907,
0.11654301732778549,
0.00009205756214214489,
-0.034736741334199905,
0.09426702558994293,
0.08820568770170212,
-0.05242123827338219,
-0.14815466105937958,
0.11957688629627228,
0.3462810218334198,
0.2722140848636627,
-0.1508283019065857,
-0.16904282569885254,
0.03993695601820946,
0.2727643549442291,
0.10586398094892502,
-0.04134216904640198,
-0.246980220079422,
0.039185844361782074,
0.1387348473072052,
-0.017105869948863983,
-0.20709718763828278,
0.10194860398769379,
-0.098721943795681,
0.043174345046281815,
-0.027315350249409676,
0.14901383221149445,
-0.04534927383065224,
-0.0371570810675621,
0.20150071382522583,
-0.17615631222724915,
-0.4002651274204254,
0.07249317318201065,
0.025484807789325714,
-0.14091069996356964,
0.042910486459732056,
0.17142954468727112,
-0.11641022562980652,
-0.05287570133805275,
0.09559452533721924,
0.04394012689590454,
0.09490519762039185,
0.05844946205615997,
-0.06442347168922424,
0.13423888385295868,
-0.13985538482666016,
-0.3257189691066742,
-0.031031491234898567,
-0.042627740651369095,
0.1739112287759781,
0.10217850655317307,
-0.006290454883128405,
-0.04888968542218208,
-0.1580597311258316,
-0.038205549120903015,
0.07302316278219223,
-0.22003939747810364,
0.035631921142339706,
0.06439556181430817,
-0.13372139632701874,
-0.0629618912935257,
0.11528851091861725,
0.15869076550006866,
-0.07106093317270279,
0.38674890995025635,
-0.12954024970531464,
0.0019477070309221745,
0.28110259771347046,
0.18365217745304108,
-0.10070683807134628,
-0.08431821316480637,
-0.06329414993524551,
0.03770122304558754,
-0.10757815092802048,
0.0342785120010376,
0.05349184572696686,
0.03676259145140648,
0.1663098782300949,
0.051122598350048065,
-0.07075660675764084,
-0.13618458807468414,
-0.12079976499080658,
-0.09333989024162292,
0.009260855615139008,
0.04215823858976364,
-0.18469461798667908,
0.14775022864341736,
-0.09244751930236816,
-0.07863626629114151,
-0.10885710269212723,
-0.048643212765455246,
0.1928427368402481,
0.016901832073926926,
-0.37355050444602966,
-0.02275446057319641,
-0.018063746392726898,
0.07685347646474838,
0.34788039326667786,
-0.18478038907051086,
0.09009342640638351,
0.2404622733592987,
-0.12318776547908783,
0.02049686387181282,
-0.07240007072687149,
-0.1730351448059082,
0.01954871229827404,
-0.12305688858032227,
0.09651798754930496,
0.05479218065738678,
0.16548319160938263,
-0.102765291929245,
0.08434415608644485,
0.03852618485689163,
0.33158695697784424,
-0.19380320608615875,
-0.06008134037256241,
0.057426225394010544,
0.022876281291246414,
-0.33642086386680603,
0.09479043632745743,
-0.20760349929332733,
-0.14348171651363373,
0.0020697189029306173,
-0.032509736716747284,
0.20485025644302368,
0.3002772927284241,
-0.1761956661939621,
-0.0739806592464447,
-0.019061481580138206,
-0.16516584157943726,
-0.1464756727218628,
0.14574797451496124,
0.18415804207324982,
-0.1542673408985138,
0.04832359775900841,
0.25470903515815735,
-0.00873264018446207,
-0.15011247992515564,
0.18961286544799805,
0.21394790709018707,
-0.08156558126211166,
0.2378339320421219,
0.24899038672447205,
0.04553494229912758,
-0.10851370543241501,
0.11569712311029434,
0.043583933264017105,
-0.02196568436920643,
-0.02469780296087265,
0.2809152603149414,
0.14099761843681335,
0.016982045024633408,
0.12714186310768127,
-0.24386602640151978,
0.18583013117313385,
0.05582362413406372,
-0.18295685946941376,
-0.08207980543375015,
0.08207876235246658,
0.1288846731185913,
0.24615685641765594,
0.04324458912014961,
0.18672606348991394,
-0.23165810108184814,
0.07502683252096176,
-0.024978363886475563,
-0.058992449194192886,
0.1461046189069748,
0.10870539397001266,
-0.01886061206459999,
0.06908044219017029,
-0.2001248300075531,
0.06207941472530365,
-0.06856083124876022,
-0.1730668991804123,
-0.2194996178150177,
0.13515020906925201,
0.09388857334852219,
-0.06739015132188797,
0.20878052711486816,
0.10007020086050034,
0.17877644300460815,
0.20197372138500214,
-0.07275528460741043,
0.041241101920604706,
0.10083767026662827,
-0.08061434328556061,
0.08577718585729599,
-0.035191744565963745,
0.010622276924550533,
-0.23717720806598663,
-0.06474433094263077,
-0.023259123787283897,
-0.0941879153251648,
0.19651930034160614,
0.20815280079841614,
0.0707852765917778,
-0.13978548347949982,
-0.22076883912086487,
0.08578420430421829,
0.001546061597764492,
-0.07592182606458664,
-0.19706928730010986,
-0.00807668175548315,
-0.085297591984272,
0.266073614358902,
0.2643541097640991,
0.190510556101799,
0.11181885749101639,
-0.11573386937379837,
0.04288994148373604,
0.0817732959985733,
-0.09118004888296127,
0.10028750449419022,
0.20274287462234497,
0.20616388320922852,
0.08067326247692108,
0.4092502295970917,
-0.09149032086133957,
-0.27226725220680237,
-0.08904989808797836,
-0.1822158247232437,
0.10589232295751572,
-0.07639056444168091,
0.10470568388700485,
0.12745948135852814,
0.18245850503444672,
0.031287968158721924,
-0.14928632974624634,
0.16463971138000488,
-0.034299395978450775,
-0.19392581284046173,
0.04517006129026413,
-0.09381029009819031,
-0.12696130573749542,
0.07494332641363144,
-0.02978435717523098,
-0.06474553048610687,
0.27697792649269104,
-0.15454262495040894,
-0.21731674671173096,
0.17005109786987305,
0.25546538829803467,
-0.24215549230575562,
0.13868634402751923,
0.0640162006020546,
0.018029604107141495,
0.07457483559846878,
0.1263895332813263,
-0.01818404346704483,
0.02606108784675598,
0.025823790580034256,
-0.09604178369045258,
0.010995643213391304,
0.13171155750751495,
-0.2261996567249298,
0.20833736658096313,
-0.08675982803106308,
0.07792919874191284,
-0.2101055532693863,
0.05485203117132187,
0.02917969413101673,
-0.1515795886516571,
-0.04820014536380768,
-0.11747471243143082,
0.0734262689948082,
0.10288674384355545,
0.15063980221748352,
0.08243238925933838,
-0.08642832189798355,
0.2363814115524292,
0.04439299926161766,
-0.013256396166980267,
-0.033851735293865204,
-0.2749153673648834,
0.15482963621616364,
-0.018259437754750252,
-0.019006062299013138,
-0.09751662611961365,
0.020899154245853424,
0.3783114552497864,
0.21629497408866882,
-0.1284802407026291,
0.11390919238328934,
0.016566313803195953,
0.07636961340904236,
0.26840367913246155,
0.31586769223213196,
-0.15983593463897705,
-0.22330662608146667,
-0.043287042528390884,
-0.1246287003159523,
-0.1296290159225464,
0.1193668320775032,
0.11655692756175995,
0.175299271941185,
0.05851462110877037,
0.06348948180675507,
-0.10280768573284149,
0.06513678282499313,
0.1686336100101471,
-0.04435897246003151,
-0.1893080770969391,
0.014987469650804996,
-0.010988603346049786,
-0.21125546097755432,
-0.18714043498039246,
-0.045752476900815964,
0.014803326688706875,
-0.07482940703630447,
0.06261678040027618,
-0.02056787721812725,
0.06650959700345993,
-0.12285547703504562,
-0.15208950638771057,
0.06321394443511963,
0.07558970898389816,
0.07331352680921555,
0.17264388501644135,
-0.06841602176427841,
-0.015795821323990822,
-0.19690774381160736,
0.17470379173755646,
0.014115824364125729,
-0.10973576456308365,
0.048619985580444336,
0.06204657256603241,
0.054011061787605286,
0.1203802227973938,
0.09570925682783127,
-0.026014072820544243,
-0.045727431774139404,
0.007341486867517233,
0.1398565173149109,
-0.05854802951216698,
-0.22504696249961853,
-0.0984136164188385,
-0.05737856775522232,
0.14806731045246124,
-0.0061541348695755005,
-0.12702146172523499,
-0.11132273823022842,
0.25676825642585754,
-0.05540267378091812,
0.11335580050945282,
-0.101252980530262,
-0.04786171019077301,
-0.10520439594984055,
-0.03312795236706734,
0.05246127024292946,
-0.1315924972295761,
-0.09104684740304947,
-0.08316131681203842,
-0.10351414233446121,
-0.14946304261684418,
-0.20350657403469086,
0.09650617837905884,
-0.021729353815317154,
-0.1563393622636795,
0.1289057582616806,
0.1806749552488327,
0.05970755219459534,
0.06251170486211777,
-0.18339915573596954,
0.11508812010288239,
0.12522073090076447,
-0.09110048413276672,
0.2880631387233734,
-0.1590193510055542,
-0.17096227407455444,
-0.17890006303787231,
0.18866027891635895,
0.00454650167375803,
0.19838182628154755,
-0.18963395059108734,
-0.04235321283340454,
-0.18827323615550995,
-0.08176808059215546,
0.0264731552451849,
-0.1514657884836197,
-0.3855533003807068,
-0.12460340559482574,
0.03461915999650955,
0.05979855731129646,
-0.34323209524154663,
0.19074727594852448,
-0.036185238510370255,
0.15492013096809387,
-0.005162631627172232,
0.026808196678757668,
0.055467236787080765,
0.276460736989975,
-0.1526576578617096,
-0.04267885163426399,
-0.23726512491703033,
-0.0542583167552948,
-0.08489280939102173,
0.20203538239002228,
0.13495072722434998,
0.12864264845848083,
-0.24344880878925323,
-0.10041291266679764,
0.11779893189668655,
0.14528357982635498,
-0.060092370957136154,
0.054126955568790436,
0.03634864464402199,
0.019517116248607635,
-0.09196574240922928,
-0.14032377302646637,
0.0880412757396698,
-0.12533609569072723,
0.10500258207321167,
-0.05621035769581795,
0.425408273935318,
-0.08396054804325104,
-0.09893003851175308,
-0.08644842356443405,
-0.009868706576526165,
-0.2050437331199646,
0.20992077887058258,
-0.1398177444934845,
0.32509467005729675,
-0.17419515550136566,
0.03648380935192108,
0.04791951924562454,
-0.16950756311416626,
0.03962140902876854,
0.07297972589731216,
-0.03770596161484718,
0.07260584086179733,
-0.0020533183123916388,
0.048570211976766586,
0.10882741957902908,
-0.02960840053856373,
0.0055384025909006596,
-0.2178768366575241,
0.09789203107357025,
-0.08858451247215271,
-0.11005598306655884,
-0.09194622933864594,
-0.05128471925854683,
0.028033260256052017,
0.1954851746559143,
-0.1502409279346466,
-0.0920548066496849,
-0.13413505256175995,
0.23877456784248352,
0.2370138168334961,
-0.09194176644086838,
0.06310670077800751,
0.1615639328956604,
-0.12703154981136322,
-0.03566872701048851,
-0.1838078647851944,
-0.08062294870615005,
0.3151082694530487,
-0.1114201471209526,
-0.18740740418434143,
-0.23343929648399353,
-0.20593681931495667,
0.12330473959445953,
0.08141187578439713,
0.1282406449317932,
-0.0140061154961586,
0.2749381959438324,
-0.054603010416030884,
-0.020272856578230858,
-0.10916239023208618,
-0.04850221425294876,
0.01788131706416607,
-0.008840703405439854,
-0.1550089716911316,
0.3623977601528168,
0.1486683040857315,
0.18682119250297546,
-0.1665107160806656,
0.05061081051826477,
0.057136449962854385,
-0.034127362072467804,
0.1036890372633934,
0.13231855630874634,
0.08310946822166443,
0.1473107933998108,
0.004087638109922409,
-0.14686018228530884,
-0.13615481555461884,
-0.10738702863454819,
0.004541315138339996,
-0.03943555802106857,
0.15419885516166687,
0.02446211501955986,
0.23120909929275513,
-0.15297961235046387,
-0.22804073989391327,
-0.06391292810440063,
0.10410303622484207,
-0.08112756162881851,
0.001120297471061349,
-0.024001536890864372,
-0.1213088259100914,
-0.03688344731926918,
0.15987369418144226,
-0.17939579486846924,
0.224635511636734,
0.20707105100154877,
-0.08579093962907791,
-0.2523020803928375,
-0.07508005201816559,
-0.18829184770584106,
0.07467078417539597,
-0.0541636198759079,
0.0540323369204998,
-0.034486692398786545,
-0.18504612147808075,
-0.06854211539030075,
0.07307229191064835,
0.04580718278884888,
0.1993972361087799,
-0.004092144779860973,
0.03736396133899689,
0.09815574437379837,
0.14269939064979553,
-0.15882694721221924,
-0.020073646679520607,
-0.12198089808225632,
-0.06036572530865669,
0.0013257738901302218,
0.11138208955526352,
0.0733751580119133,
0.21459417045116425,
-0.05535600334405899,
0.06442411988973618,
-0.15926715731620789,
-0.18622508645057678,
0.12215639650821686,
0.098710797727108,
-0.007605845108628273,
-0.09424833208322525,
-0.0015123692573979497,
-0.18897129595279694,
-0.01603209227323532,
-0.10745937377214432,
-0.09850980341434479,
-0.08761853724718094
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. to prolidase deficiency. Other names used in the past include imidodipeptidase deficiency and peptidase D deficiency.PrevalenceApproximately 90 affected individuals have been reported in the literature; however, prolidase deficiency likely remains underdiagnosed as a result of under-recognition by physicians.The Québec Newborn Urine Screening Program (Programme québécois de dépistage neonatal Urinaire, PQDNU) identified two affected infants out of 2,469,929 screened between 1973 and 2006, for an incidence of 1:1,235,000 . Thus, a few thousand cases would be predicted to exist worldwide, as opposed to only 90 cases reported to date.Prolidase deficiency has been diagnosed throughout the world .A founder variant has been described in the Geauga County settlement in Ohio , as well as in the Druze population in northern Israel, the latter with a carrier frequency of 1:21 .Differential DiagnosisDisorders with Imidodipe | [
-0.10185246169567108,
0.22610017657279968,
0.02168324775993824,
-0.18304942548274994,
0.0772203579545021,
0.21646341681480408,
-0.07628438621759415,
-0.09593010693788528,
0.037734124809503555,
-0.03542985022068024,
0.034101635217666626,
0.2192811220884323,
0.19273720681667328,
0.028219591826200485,
-0.05780476704239845,
0.13398565351963043,
0.19204597175121307,
-0.01836777664721012,
-0.03425528481602669,
-0.031604964286088943,
0.04683065414428711,
-0.16245169937610626,
0.1866045892238617,
0.20969444513320923,
0.21877145767211914,
-0.050923317670822144,
-0.006726650055497885,
0.06858628988265991,
0.032403651624917984,
-0.015295060351490974,
0.020313119515776634,
-0.08897048979997635,
0.027453824877738953,
-0.11662851274013519,
0.12395372241735458,
-0.012802406214177608,
-0.11135516315698624,
0.04478425905108452,
0.175783172249794,
-0.04027331620454788,
-0.07848905771970749,
-0.043390803039073944,
0.12465278059244156,
0.13584646582603455,
-0.029898839071393013,
-0.05972423776984215,
0.08653748035430908,
0.0660323053598404,
-0.10777483880519867,
0.09269139170646667,
0.27521416544914246,
-0.08746232092380524,
-0.025182140991091728,
-0.10804876685142517,
0.2597278356552124,
0.20008042454719543,
0.09296296536922455,
0.11369635909795761,
-0.07652325183153152,
-0.050395671278238297,
0.051787152886390686,
-0.06686152517795563,
-0.047548770904541016,
-0.3772790729999542,
0.18620343506336212,
-0.0627438947558403,
0.21630828082561493,
-0.07464256137609482,
-0.07634031027555466,
-0.0897369384765625,
0.4089582562446594,
0.09736795723438263,
0.2564859092235565,
0.01117817685008049,
-0.12023661285638809,
0.17198219895362854,
0.09301851689815521,
0.015465090982615948,
0.03212994337081909,
-0.15277959406375885,
-0.18035203218460083,
0.15398669242858887,
0.09876859933137894,
0.26296907663345337,
-0.05303330346941948,
0.22171734273433685,
0.11649461835622787,
0.3337967097759247,
0.1395835429430008,
0.03983280435204506,
0.04262430593371391,
-0.23164957761764526,
0.10521704703569412,
-0.20527668297290802,
-0.047202810645103455,
-0.09966562688350677,
-0.04554793983697891,
0.13106131553649902,
-0.10257024317979813,
0.19511637091636658,
0.06951542943716049,
0.07706159353256226,
-0.06355322897434235,
0.005342184565961361,
0.1628355085849762,
-0.19362805783748627,
-0.18075791001319885,
-0.0877043604850769,
-0.10080376267433167,
-0.1112089678645134,
0.07239095121622086,
-0.07113999128341675,
-0.08854912966489792,
0.05650903284549713,
-0.09187044948339462,
-0.05052487179636955,
0.18852709233760834,
-0.2012418508529663,
-0.06015869975090027,
-0.17982631921768188,
0.04876655340194702,
0.050270866602659225,
0.0617326945066452,
-0.28391706943511963,
0.1553543210029602,
0.10148171335458755,
0.010516845621168613,
0.16901925206184387,
0.1727270483970642,
-0.09983368963003159,
0.15813963115215302,
0.05609896406531334,
0.006506201811134815,
-0.17465095221996307,
-0.012603644281625748,
0.06155133619904518,
-0.22013531625270844,
-0.10855366289615631,
-0.04584247246384621,
-0.01180738303810358,
0.0027797785587608814,
0.03231643885374069,
0.21186856925487518,
0.2117403894662857,
-0.018989549949765205,
0.16027675569057465,
0.3688693344593048,
-0.12384101748466492,
0.02786187455058098,
-0.05456412956118584,
0.026838695630431175,
-0.0523785762488842,
0.4032779633998871,
0.060764752328395844,
-0.03471213951706886,
0.05997127294540405,
-0.13118590414524078,
0.15091769397258759,
-0.15421955287456512,
0.18620117008686066,
0.03343989700078964,
-0.10482596606016159,
0.09205855429172516,
-0.1473647803068161,
0.2201208770275116,
-0.03145141527056694,
-0.14320515096187592,
0.02268723025918007,
0.0649222880601883,
0.03128657117486,
-0.12303636223077774,
0.03746818006038666,
0.042820367962121964,
0.05357344076037407,
0.150337353348732,
-0.13870452344417572,
-0.017409536987543106,
0.04896486550569534,
-0.014752324670553207,
-0.014972814358770847,
-0.017506813630461693,
0.01859920658171177,
-0.05347639322280884,
-0.026321014389395714,
-0.16338211297988892,
-0.171128511428833,
0.019292285665869713,
0.19265784323215485,
0.10415823012590408,
0.17236578464508057,
0.06528855860233307,
0.18014639616012573,
-0.10719851404428482,
-0.15580128133296967,
0.17513945698738098,
-0.19384537637233734,
0.05842728540301323,
-0.07604006677865982,
-0.10477830469608307,
-0.09354422986507416,
0.16615808010101318,
-0.09270875155925751,
0.20543469488620758,
-0.0988055020570755,
0.06607724726200104,
0.06723464280366898,
0.02396761253476143,
-0.03197503462433815,
-0.10523222386837006,
0.3242981731891632,
-0.03655295446515083,
0.07104948163032532,
-0.05308505892753601,
0.21045085787773132,
-0.12304122000932693,
-0.05259816348552704,
-0.16456110775470734,
-0.06945239752531052,
-0.03221997618675232,
-0.011630198918282986,
-0.12108204513788223,
-0.044287875294685364,
-0.1156553104519844,
-0.20710238814353943,
-0.016576223075389862,
0.08264891058206558,
-0.08132123947143555,
0.056088030338287354,
0.18519710004329681,
-0.10530361533164978,
-0.11280000954866409,
0.08041021227836609,
0.2573084831237793,
0.15515320003032684,
-0.048103272914886475,
-0.12995579838752747,
-0.014050452969968319,
0.1787562221288681,
0.1352900117635727,
-0.10574585199356079,
-0.26172471046447754,
0.049575336277484894,
0.07174275815486908,
-0.1238938570022583,
-0.07713887095451355,
0.08895804733037949,
-0.06401005387306213,
0.10967312008142471,
-0.03862806037068367,
0.09280920773744583,
-0.08545762300491333,
0.02636660449206829,
0.1633853018283844,
-0.08702614903450012,
-0.41196587681770325,
-0.016613440588116646,
0.0951981171965599,
-0.025732100009918213,
0.08280358463525772,
0.18421995639801025,
-0.024644456803798676,
-0.010634779930114746,
0.04460366815328598,
0.044081054627895355,
-0.015776872634887695,
-0.017165370285511017,
-0.15266826748847961,
0.05925242230296135,
-0.09385406970977783,
-0.3840988278388977,
-0.03561573475599289,
-0.00781546626240015,
0.18228952586650848,
0.138643279671669,
-0.04707133024930954,
-0.10833573341369629,
-0.1901620328426361,
0.05519601330161095,
0.04480024799704552,
-0.12444236129522324,
0.0285454411059618,
0.03415462374687195,
-0.07457900792360306,
-0.13129687309265137,
0.2009047418832779,
0.0390767976641655,
0.0354892835021019,
0.22694960236549377,
-0.13677309453487396,
-0.0069098141975700855,
0.2000514268875122,
0.18245166540145874,
-0.12336394935846329,
-0.06877464801073074,
0.11008038371801376,
0.06169417127966881,
-0.11884626746177673,
0.0031023542396724224,
0.09929590672254562,
0.1034104973077774,
0.1806858330965042,
0.0207402091473341,
-0.05951441824436188,
-0.09184623509645462,
-0.07851077616214752,
-0.06687100231647491,
0.053640082478523254,
-0.05858536809682846,
-0.1346103996038437,
0.16416987776756287,
-0.18020012974739075,
-0.07906435430049896,
-0.17863744497299194,
-0.06628969311714172,
0.1608848124742508,
-0.007329790852963924,
-0.30067387223243713,
0.07763733714818954,
0.0685855969786644,
0.15730272233486176,
0.31560018658638,
-0.14305737614631653,
0.048983361572027206,
0.17610497772693634,
-0.09488506615161896,
0.06734124571084976,
-0.17967098951339722,
0.0035485594999045134,
0.04013356566429138,
-0.05245450511574745,
0.11512576043605804,
0.07199957221746445,
-0.026469901204109192,
-0.03513448312878609,
0.12328340113162994,
-0.00010218813986284658,
0.2774212062358856,
-0.1923413872718811,
-0.05162398889660835,
0.01960817351937294,
0.02164340205490589,
-0.07396171987056732,
0.09156759828329086,
-0.0782940685749054,
-0.10170619189739227,
-0.02380048856139183,
0.035677146166563034,
0.07177338004112244,
0.18691539764404297,
-0.10298419743776321,
-0.13246025145053864,
-0.013825848698616028,
-0.014166140928864479,
-0.16799339652061462,
0.2309512197971344,
0.02839072234928608,
-0.18643665313720703,
0.05933406949043274,
0.19363194704055786,
-0.0327991284430027,
-0.14798246324062347,
0.0933891236782074,
0.2384984791278839,
-0.12920443713665009,
0.17253537476062775,
0.23986448347568512,
0.12342767417430878,
0.0009608610416762531,
0.03149167820811272,
0.059836745262145996,
0.02561955899000168,
-0.037247925996780396,
0.1627817302942276,
0.10438307374715805,
0.03987523540854454,
0.14461776614189148,
-0.12986348569393158,
0.31053027510643005,
0.02002435363829136,
-0.18159490823745728,
-0.04422494396567345,
0.07838105410337448,
0.11330702900886536,
0.22097226977348328,
0.017368847504258156,
0.24562692642211914,
-0.18333296477794647,
-0.06853625923395157,
0.04521305486559868,
-0.07368702441453934,
0.07585853338241577,
0.08548115193843842,
0.060179173946380615,
0.11337713152170181,
-0.22048495709896088,
0.058244358748197556,
-0.032469358295202255,
-0.04560571163892746,
-0.18736277520656586,
0.034638822078704834,
-0.022124335169792175,
-0.13580818474292755,
0.09413675218820572,
0.03846154734492302,
0.10365241020917892,
0.11777105182409286,
-0.061142873018980026,
0.1303255558013916,
0.02480442449450493,
-0.15212219953536987,
0.1319233626127243,
-0.027328958734869957,
-0.06496857106685638,
-0.23154103755950928,
0.04189823567867279,
0.002782628173008561,
-0.07665669173002243,
0.09377612918615341,
0.16281883418560028,
0.1798984706401825,
-0.16206826269626617,
-0.015360997058451176,
0.10622015595436096,
-0.018096158280968666,
-0.09888340532779694,
-0.14296510815620422,
0.09983386099338531,
-0.02658141776919365,
0.2115502804517746,
0.1897946447134018,
0.2222735583782196,
0.08895096182823181,
-0.1065603569149971,
0.05354124307632446,
-0.012548004277050495,
-0.0042114281095564365,
0.06876171380281448,
0.0813816711306572,
0.18810884654521942,
0.08763180673122406,
0.19945812225341797,
-0.0030926084145903587,
-0.23165291547775269,
-0.11758692562580109,
-0.08315589278936386,
0.03873090818524361,
-0.038000479340553284,
0.053787413984537125,
0.11920125782489777,
0.15179339051246643,
-0.05026845261454582,
-0.09803257882595062,
0.09588354080915451,
-0.07660867273807526,
-0.12594974040985107,
0.10334086418151855,
-0.11682795733213425,
-0.1280193030834198,
0.0636473149061203,
-0.03541149944067001,
-0.09098359942436218,
0.27083587646484375,
-0.040952831506729126,
-0.10839125514030457,
0.08189255744218826,
0.18193671107292175,
-0.10120591521263123,
0.05565323308110237,
0.053241066634655,
-0.02147410251200199,
0.20418839156627655,
0.08103971928358078,
-0.040020085871219635,
-0.15228202939033508,
-0.06922708451747894,
-0.0015008416958153248,
0.06657544523477554,
0.09655207395553589,
-0.12131038308143616,
0.188955157995224,
-0.06725761294364929,
-0.005298393778502941,
-0.23536549508571625,
-0.06579031050205231,
-0.04829778894782066,
-0.08550404012203217,
-0.01777023822069168,
-0.09383274614810944,
0.13515807688236237,
0.0849088802933693,
0.13877813518047333,
0.14916495978832245,
-0.031408101320266724,
0.2918755114078522,
0.04559467360377312,
-0.1128845289349556,
-0.005019253585487604,
-0.26465901732444763,
0.03983249142765999,
-0.09066200256347656,
-0.011839248239994049,
0.0464765802025795,
0.013563578017055988,
0.4094334840774536,
0.15333309769630432,
-0.06806197017431259,
-0.06498361378908157,
-0.045917753130197525,
0.129350483417511,
0.21783886849880219,
0.2336890995502472,
-0.08922379463911057,
-0.263600617647171,
-0.05776040256023407,
-0.10096673667430878,
-0.22104358673095703,
0.22510357201099396,
0.0845770463347435,
0.15523818135261536,
0.04735254868865013,
0.07102657854557037,
-0.11070984601974487,
0.008595621213316917,
0.10128895938396454,
0.020370379090309143,
-0.11229468137025833,
0.05895804613828659,
0.0498855821788311,
-0.1667207032442093,
-0.23945991694927216,
-0.07681697607040405,
-0.09025447815656662,
-0.11999411135911942,
0.08699686080217361,
-0.014804530888795853,
-0.03492095693945885,
-0.08069898933172226,
-0.13771255314350128,
0.04921101778745651,
0.03729570657014847,
0.13299424946308136,
0.09838932752609253,
-0.008391983807086945,
0.029006730765104294,
-0.05392324924468994,
0.1555352658033371,
0.1407187283039093,
-0.09814673662185669,
0.09905427694320679,
0.09472131729125977,
-0.07645495980978012,
0.09261784702539444,
-0.022640172392129898,
0.013465170748531818,
-0.04811601713299751,
-0.055394258350133896,
-0.008702903054654598,
-0.1631816327571869,
-0.23061618208885193,
-0.12566348910331726,
-0.05364498496055603,
0.006346350535750389,
0.006472757551819086,
-0.1321404129266739,
-0.07352717965841293,
0.23675642907619476,
-0.08149689435958862,
-0.036109331995248795,
-0.007140894420444965,
-0.13750241696834564,
-0.15103335678577423,
-0.016464531421661377,
0.08114390820264816,
-0.1726817786693573,
-0.22641102969646454,
-0.1355084776878357,
-0.12795735895633698,
-0.1526157110929489,
-0.24383360147476196,
0.18738137185573578,
-0.021483637392520905,
-0.14098331332206726,
-0.008549395017325878,
0.20077811181545258,
0.2114899456501007,
0.05436442792415619,
0.013903654180467129,
0.09664887189865112,
0.11334668844938278,
-0.06452514976263046,
0.14728762209415436,
-0.17913700640201569,
-0.07778792828321457,
-0.1323600709438324,
0.16986027359962463,
0.014095797203481197,
0.12903280556201935,
-0.11550702899694443,
0.052994485944509506,
-0.16584515571594238,
-0.14682750403881073,
0.09022801369428635,
-0.11890850216150284,
-0.22865337133407593,
-0.007073636166751385,
0.04798983410000801,
0.11513049900531769,
-0.31378188729286194,
0.18202818930149078,
-0.005331451538950205,
0.0842302069067955,
-0.0830177590250969,
-0.049140479415655136,
0.014185580424964428,
0.2524320185184479,
-0.07429917901754379,
-0.011026408523321152,
-0.12898299098014832,
-0.028952963650226593,
-0.07871811836957932,
0.15423542261123657,
0.0875183567404747,
0.13254085183143616,
-0.20173773169517517,
-0.07223602384328842,
0.07507453113794327,
0.16555705666542053,
-0.01170438714325428,
0.1718929558992386,
0.08895070850849152,
-0.06108889356255531,
0.06680317968130112,
-0.164181649684906,
0.04730505868792534,
-0.14968252182006836,
0.08681786805391312,
0.0036108719650655985,
0.2927674949169159,
-0.08204390108585358,
-0.10129871219396591,
-0.02177250012755394,
0.09208177030086517,
-0.07919930666685104,
0.23454447090625763,
-0.13175015151500702,
0.3262878656387329,
-0.08335689455270767,
0.05274758115410805,
-0.03329622000455856,
-0.08232434093952179,
0.05626136064529419,
0.03319291025400162,
-0.02423471212387085,
0.14176906645298004,
-0.05903356149792671,
0.09083525091409683,
0.07999646663665771,
-0.0868479460477829,
0.14415283501148224,
-0.2737636864185333,
0.016039619222283363,
-0.048136256635189056,
-0.05278731882572174,
0.07313734292984009,
0.015413571149110794,
0.03467283025383949,
0.1930815726518631,
-0.09646788984537125,
-0.04130919277667999,
-0.15292999148368835,
0.13740278780460358,
0.17602621018886566,
-0.0789175033569336,
0.029087085276842117,
0.07974158227443695,
-0.082832932472229,
-0.06812963634729385,
-0.1939474493265152,
-0.04519539698958397,
0.20210666954517365,
-0.002945450833067298,
-0.19023281335830688,
-0.13227792084217072,
-0.13404379785060883,
0.08773449063301086,
0.15590079128742218,
0.09403473883867264,
0.053645260632038116,
0.18585246801376343,
-0.08412520587444305,
-0.10814853012561798,
-0.06569767743349075,
0.06313363462686539,
0.13777171075344086,
-0.05045449733734131,
-0.07847007364034653,
0.3181925415992737,
0.10638632625341415,
0.0737679973244667,
-0.1808161586523056,
0.07842404395341873,
-0.061400141566991806,
0.0035348164383322,
0.09792120009660721,
0.04919179528951645,
0.06594423949718475,
0.10100389271974564,
0.11877372860908508,
-0.10881025344133377,
-0.04344910383224487,
-0.11379794776439667,
-0.09649159014225006,
-0.00214956421405077,
0.2807442247867584,
-0.08134667575359344,
0.23511198163032532,
-0.1643705517053604,
-0.07751224935054779,
-0.056983835995197296,
0.09637629240751266,
-0.019677022472023964,
-0.06516674906015396,
0.008102544583380222,
-0.13030566275119781,
0.02828914485871792,
0.14498266577720642,
-0.14235767722129822,
0.11810975521802902,
0.21246953308582306,
-0.03769350051879883,
-0.19231106340885162,
-0.1291496306657791,
-0.1680990308523178,
0.13320954144001007,
-0.0868118405342102,
0.10740119218826294,
-0.00783275905996561,
0.07657924294471741,
0.015711458399891853,
0.050588466227054596,
0.049303747713565826,
0.19229744374752045,
-0.08316870778799057,
-0.047469135373830795,
0.11146783828735352,
0.14597223699092865,
-0.1150774285197258,
-0.06688029319047928,
-0.16127771139144897,
-0.06438306719064713,
0.1404702216386795,
0.12616552412509918,
0.03379086032509804,
0.10098841041326523,
-0.08949954062700272,
0.13136804103851318,
-0.11426018923521042,
-0.18231280148029327,
0.11437609046697617,
0.03535047173500061,
-0.07718277722597122,
-0.009188374504446983,
-0.03655814751982689,
-0.10609320551156998,
-0.11492276936769485,
-0.08053392171859741,
-0.019681837409734726,
-0.0750381350517273
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. screened between 1973 and 2006, for an incidence of 1:1,235,000 . Thus, a few thousand cases would be predicted to exist worldwide, as opposed to only 90 cases reported to date.Prolidase deficiency has been diagnosed throughout the world .A founder variant has been described in the Geauga County settlement in Ohio , as well as in the Druze population in northern Israel, the latter with a carrier frequency of 1:21 .Differential DiagnosisDisorders with ImidodipeptiduriaImidodipeptiduria has been described in bone disorders, presumably originating from collagen under conditions of high bone turnover.Glycylproline has been found in the urine of:A child with severe bone disease and hyperphosphatasia ;Two sisters with multiple fractures and striking bone deformities of unknown etiology ;A woman age 28 years with osteomalacia and severe hyperparathyroidism who excreted large amounts of glycylproline, equivalent to ~1 g/day ; | [
-0.013287421315908432,
0.16289815306663513,
-0.09794005751609802,
-0.1325053870677948,
0.28257226943969727,
0.09761114418506622,
0.09302650392055511,
-0.14450661838054657,
-0.039095692336559296,
-0.21099667251110077,
0.19728974997997284,
0.23483653366565704,
0.05927545204758644,
0.021229537203907967,
-0.11280091106891632,
0.06862739473581314,
0.1759800761938095,
-0.01158612035214901,
-0.1080579161643982,
-0.07310238480567932,
0.043276432901620865,
0.04961612820625305,
0.23190344870090485,
0.08685756474733353,
0.2271902710199356,
0.0486992709338665,
-0.04185307398438454,
-0.028153980150818825,
0.022778864949941635,
-0.07731698453426361,
-0.15824300050735474,
-0.06893058866262436,
0.03672516345977783,
-0.23845119774341583,
0.28192201256752014,
-0.11109387874603271,
-0.08860991895198822,
-0.17822018265724182,
0.08837024867534637,
-0.025205034762620926,
0.016618428751826286,
-0.059914570301771164,
0.21031931042671204,
-0.05983658879995346,
-0.043916840106248856,
0.009950005449354649,
-0.08022015541791916,
0.09737730026245117,
-0.1377895325422287,
0.14826281368732452,
0.2928597331047058,
-0.16961805522441864,
-0.03519635647535324,
-0.02624070830643177,
0.09160320460796356,
-0.006292004603892565,
0.11984118819236755,
0.0721765086054802,
-0.08100158721208572,
0.05498470366001129,
-0.047011468559503555,
-0.03434683755040169,
-0.09374769032001495,
-0.3848890960216522,
0.1475338190793991,
-0.010982809588313103,
0.16288864612579346,
-0.11803372949361801,
-0.16450214385986328,
-0.04355669394135475,
0.4210472106933594,
0.08912592381238937,
0.27264827489852905,
0.1124424934387207,
-0.21302002668380737,
-0.1438722312450409,
0.06712649017572403,
-0.11185099929571152,
0.036170363426208496,
-0.11768385767936707,
-0.2686261236667633,
0.16835395991802216,
0.07148992270231247,
-0.004727927967905998,
-0.19237877428531647,
0.2959674894809723,
0.13937214016914368,
0.25403890013694763,
-0.0036692009307444096,
0.1364012509584427,
0.09071877598762512,
-0.17520707845687866,
0.19017522037029266,
-0.229538232088089,
-0.07960746437311172,
-0.1714775413274765,
0.17704345285892487,
0.03289356082677841,
-0.044844359159469604,
0.1984531432390213,
0.080916628241539,
0.07468172162771225,
-0.029623156413435936,
0.014734418131411076,
0.05368811637163162,
-0.0033565587364137173,
-0.1875288039445877,
-0.1135953813791275,
-0.005055699497461319,
-0.0604720301926136,
0.12063352018594742,
0.018166497349739075,
-0.009116659872233868,
0.10064605623483658,
-0.14382266998291016,
0.11356274783611298,
0.24745476245880127,
-0.11765263974666595,
-0.145636186003685,
-0.07357265055179596,
-0.10892029106616974,
0.1531398743391037,
-0.007613218389451504,
-0.12302133440971375,
0.1894802302122116,
0.21214768290519714,
0.11445500701665878,
-0.025023549795150757,
0.26941049098968506,
-0.07339507341384888,
0.0710701048374176,
-0.02469990961253643,
0.1221890076994896,
-0.1601305603981018,
-0.07510916888713837,
0.06261231750249863,
-0.2589434087276459,
-0.06472043693065643,
-0.09017479419708252,
0.0995599552989006,
0.0031154300086200237,
0.05456142872571945,
0.20433732867240906,
0.2609108090400696,
-0.0067232693545520306,
0.19211383163928986,
0.290834903717041,
-0.06374797224998474,
0.16985909640789032,
0.07890298217535019,
0.09037094563245773,
-0.1325107365846634,
0.3287512958049774,
-0.06109518185257912,
0.12041135877370834,
0.12674473226070404,
-0.2407999336719513,
-0.0114007368683815,
-0.09173868596553802,
0.11206352710723877,
0.02994474768638611,
-0.05507795140147209,
0.11193210631608963,
-0.1994290053844452,
0.05929394066333771,
-0.1281731277704239,
-0.12067185342311859,
0.06549280136823654,
0.004140313249081373,
-0.026837898418307304,
-0.050176918506622314,
0.06397774815559387,
-0.04233275726437569,
0.02901536040008068,
0.14817017316818237,
-0.28336453437805176,
0.01979319378733635,
0.005467649549245834,
-0.081425242125988,
0.22286881506443024,
0.07328440994024277,
0.000975009286776185,
-0.09034811705350876,
-0.024961356073617935,
-0.14012305438518524,
-0.07962968945503235,
-0.05216612294316292,
0.19226513803005219,
0.17743372917175293,
0.24545633792877197,
0.06674724072217941,
0.08277518302202225,
-0.03589130938053131,
-0.10919835418462753,
0.15256378054618835,
-0.22364933788776398,
0.05018172413110733,
-0.13720691204071045,
-0.22265125811100006,
-0.022006377577781677,
0.24757429957389832,
-0.24449674785137177,
0.2766264081001282,
-0.09140157699584961,
0.12593333423137665,
0.07007233798503876,
0.0013698552502319217,
0.09560228139162064,
-0.039185039699077606,
0.26530590653419495,
0.054066698998212814,
0.14680512249469757,
-0.09774455428123474,
0.23199747502803802,
-0.06503942608833313,
-0.02935488149523735,
-0.12774835526943207,
-0.05087390914559364,
-0.19519366323947906,
0.0462406650185585,
-0.017725922167301178,
0.034707821905612946,
-0.08430315554141998,
-0.20151139795780182,
-0.10467491298913956,
0.08601003140211105,
-0.04587138071656227,
0.12853723764419556,
0.09027386456727982,
0.1447833925485611,
-0.09053921699523926,
0.039744507521390915,
0.31564581394195557,
0.19126717746257782,
-0.11870380491018295,
-0.25158438086509705,
0.0023475484922528267,
0.1345045268535614,
0.015342030674219131,
-0.09629719704389572,
-0.3033396601676941,
0.013036475516855717,
0.007572519592940807,
-0.15774351358413696,
-0.01329480204731226,
0.013964143581688404,
-0.05129922926425934,
0.08000653237104416,
-0.06253665685653687,
0.007362163159996271,
-0.1453971415758133,
0.11169442534446716,
0.3173138499259949,
-0.19951534271240234,
-0.31229060888290405,
0.07438385486602783,
0.18879641592502594,
-0.07925071567296982,
0.1443285048007965,
0.16358055174350739,
-0.06142816320061684,
-0.02267853170633316,
0.08458065986633301,
0.04548852518200874,
-0.021560005843639374,
-0.07867556065320969,
-0.09595959633588791,
0.196550190448761,
-0.19624488055706024,
-0.29510390758514404,
0.13493511080741882,
-0.08206010609865189,
0.2861711382865906,
0.08756517618894577,
-0.14693109691143036,
-0.11130636185407639,
-0.09946015477180481,
-0.011517914943397045,
0.13634517788887024,
-0.1634313017129898,
0.0031383000314235687,
0.12780755758285522,
-0.17513126134872437,
-0.02959246002137661,
0.2268984466791153,
0.04891439899802208,
-0.04370715096592903,
0.2823233902454376,
-0.2252383530139923,
0.04753047600388527,
0.2316124588251114,
0.16170167922973633,
-0.03256839141249657,
-0.07447945326566696,
0.09065151959657669,
-0.009850284084677696,
-0.20471781492233276,
-0.04189608246088028,
0.11678409576416016,
0.0745665654540062,
0.20075370371341705,
0.11267063766717911,
0.00018538122822064906,
0.017134062945842743,
-0.19782820343971252,
-0.043614424765110016,
-0.0255762729793787,
-0.017560278996825218,
-0.16617771983146667,
0.00692511023953557,
-0.15459036827087402,
-0.1857493817806244,
-0.1363106071949005,
-0.11692073941230774,
0.10841144621372223,
0.03299788758158684,
-0.2566380500793457,
0.12059847265481949,
0.0435795933008194,
0.1048307865858078,
0.2673347592353821,
-0.06513369828462601,
0.04899271950125694,
0.2870189845561981,
-0.011811703443527222,
0.21495823562145233,
-0.15496696531772614,
-0.058940012007951736,
0.06465919315814972,
-0.12725132703781128,
0.10542626678943634,
0.07526278495788574,
-0.021712208166718483,
-0.18830141425132751,
0.12126872688531876,
0.2163020521402359,
0.2687963545322418,
-0.024284018203616142,
-0.03158025071024895,
0.022600242868065834,
0.0007388064987026155,
-0.2748301923274994,
-0.08659657835960388,
-0.08650138229131699,
-0.08077047020196915,
-0.04930834472179413,
0.04706723615527153,
0.1756119728088379,
0.3142716884613037,
-0.1746739149093628,
-0.10250884294509888,
0.1049220934510231,
-0.005114285741001368,
-0.04309994354844093,
0.14977283775806427,
0.04731254279613495,
-0.22447305917739868,
0.1332782655954361,
0.24389460682868958,
-0.15217125415802002,
-0.08370541781187057,
0.07859904319047928,
0.23456987738609314,
-0.19853781163692474,
0.1966584026813507,
0.1558251976966858,
0.1444212943315506,
-0.017585299909114838,
-0.07914768904447556,
0.0006005441537126899,
-0.048760633915662766,
-0.23222553730010986,
0.18248297274112701,
0.1935417205095291,
-0.04479993134737015,
0.03571837767958641,
-0.14904968440532684,
0.07668842375278473,
0.013515348546206951,
-0.019266784191131592,
-0.0986756756901741,
0.08026731759309769,
0.09789431840181351,
0.2948366701602936,
-0.005992195103317499,
0.23530231416225433,
-0.061454132199287415,
0.04267748445272446,
0.04699213430285454,
-0.0350225567817688,
0.07814906537532806,
0.16001226007938385,
-0.04075077176094055,
0.11952970176935196,
-0.07963871210813522,
0.1260676383972168,
-0.09804639965295792,
-0.0625874325633049,
-0.21546290814876556,
0.17741940915584564,
0.11020989716053009,
0.13515055179595947,
0.09449813514947891,
0.1601550579071045,
0.11638347804546356,
0.2030513733625412,
-0.0402909517288208,
0.12946674227714539,
0.08099303394556046,
-0.07567954808473587,
0.021177981048822403,
-0.08859724551439285,
-0.10284143686294556,
-0.14387640357017517,
0.014692680910229683,
0.018449604511260986,
-0.0883546769618988,
0.14348921179771423,
0.015528230927884579,
0.13744430243968964,
-0.292542040348053,
-0.16662441194057465,
0.13867223262786865,
0.006932099815458059,
-0.1959276795387268,
-0.08458590507507324,
0.050900816917419434,
-0.08150775730609894,
0.05007552728056908,
0.13150930404663086,
0.07935608178377151,
0.1093185693025589,
-0.0348062701523304,
-0.04404394328594208,
0.16258127987384796,
0.02705276571214199,
-0.03510982543230057,
-0.008551981300115585,
0.18887978792190552,
0.10740285366773605,
0.31799620389938354,
-0.19775134325027466,
-0.19640760123729706,
-0.10026877373456955,
-0.16075275838375092,
0.1155657172203064,
-0.02346963807940483,
0.01985584758222103,
0.09779715538024902,
0.07824033498764038,
0.03616592660546303,
-0.01817578263580799,
0.2643076777458191,
-0.10810708999633789,
-0.2600794732570648,
0.022152647376060486,
-0.12518540024757385,
-0.18476451933383942,
-0.060059744864702225,
0.03447774425148964,
-0.05800176411867142,
0.06320120394229889,
-0.08121152222156525,
-0.2311660498380661,
0.147838294506073,
0.2907247245311737,
-0.25869160890579224,
0.09100134670734406,
-0.03147532418370247,
-0.15903742611408234,
0.08291229605674744,
0.12374060600996017,
-0.11250682920217514,
-0.08191786706447601,
-0.12302041798830032,
-0.06541905552148819,
-0.07828786224126816,
0.07759212702512741,
-0.21270796656608582,
0.1471175104379654,
-0.011595534160733223,
0.0603918693959713,
-0.2233087718486786,
0.07704094797372818,
0.12503878772258759,
-0.18757767975330353,
0.11903869360685349,
-0.09396521002054214,
0.14553184807300568,
0.17081253230571747,
0.21529562771320343,
0.16692869365215302,
0.05537962168455124,
0.36071696877479553,
0.1625920832157135,
-0.01585942693054676,
0.004432074725627899,
-0.19039221107959747,
0.02527250535786152,
-0.08951045572757721,
-0.011471460573375225,
-0.260518342256546,
0.0483258031308651,
0.11790186911821365,
0.19961783289909363,
-0.12681621313095093,
0.16042964160442352,
-0.005306919105350971,
0.0666017159819603,
0.3529154360294342,
0.3154182732105255,
-0.03759092837572098,
-0.2531678378582001,
-0.14836525917053223,
-0.03841078281402588,
-0.1102808266878128,
0.1740790158510208,
0.21545201539993286,
0.13623158633708954,
-0.06729361414909363,
-0.023941325023770332,
-0.11388183385133743,
-0.0646807849407196,
0.17757953703403473,
-0.06482148915529251,
-0.13103128969669342,
0.15612322092056274,
0.0485198087990284,
-0.26189613342285156,
-0.20196747779846191,
-0.03668192774057388,
-0.09764199703931808,
-0.02021915093064308,
-0.02669460140168667,
0.06331317871809006,
0.07501979917287827,
-0.07903026044368744,
-0.11528441309928894,
0.06756158918142319,
0.10703545808792114,
-0.0014671047683805227,
0.09610188007354736,
-0.0521426796913147,
0.2048342376947403,
-0.2203095257282257,
0.12959662079811096,
0.029915373772382736,
-0.14681628346443176,
0.06171969324350357,
0.08493413776159286,
-0.14537374675273895,
0.14481842517852783,
-0.05992532894015312,
0.08491446822881699,
0.017727728933095932,
-0.04185202717781067,
0.16440460085868835,
-0.06537866592407227,
-0.11738594621419907,
-0.1040126234292984,
0.08545433729887009,
0.1982598751783371,
-0.021557006984949112,
-0.17062081396579742,
-0.21316200494766235,
0.18177582323551178,
-0.11929915100336075,
0.05415697023272514,
-0.1493433564901352,
-0.22293983399868011,
-0.06264948099851608,
0.05068144202232361,
-0.06046154722571373,
-0.3161047101020813,
-0.25068455934524536,
-0.026116011664271355,
-0.21808423101902008,
-0.18579289317131042,
0.05103271082043648,
0.15050940215587616,
-0.055768921971321106,
-0.07366565614938736,
0.2019515186548233,
0.07271138578653336,
0.08000527322292328,
0.08327202498912811,
-0.04241146892309189,
0.06241811066865921,
0.16163979470729828,
0.015444045886397362,
0.21618281304836273,
-0.21378320455551147,
-0.0442880280315876,
-0.07422331720590591,
0.1203780546784401,
0.04716763272881508,
0.17656923830509186,
-0.22576487064361572,
0.16195185482501984,
0.017645128071308136,
-0.02544073946774006,
-0.015902137383818626,
-0.24665209650993347,
-0.1673049032688141,
-0.031363386660814285,
-0.018022684380412102,
0.11797475069761276,
-0.28247329592704773,
0.009391169995069504,
0.14436998963356018,
0.17062439024448395,
-0.05742383003234863,
0.04433540254831314,
0.04193282872438431,
0.2888607084751129,
-0.10981660336256027,
0.08189668506383896,
-0.19608469307422638,
-0.0615999698638916,
-0.12733496725559235,
0.25719234347343445,
0.1584964096546173,
0.17872770130634308,
-0.23631392419338226,
0.005344281438738108,
0.11655036360025406,
0.11356163024902344,
-0.18136076629161835,
0.05740711838006973,
0.0987401157617569,
-0.027441201731562614,
-0.061513397842645645,
-0.1674429029226303,
0.1782340258359909,
-0.19666224718093872,
0.17748579382896423,
-0.041636478155851364,
0.2705504894256592,
-0.03487752377986908,
-0.1475103348493576,
-0.0176404919475317,
0.08941726386547089,
-0.18551011383533478,
0.14923565089702606,
-0.07452256232500076,
0.3307081162929535,
-0.10252456367015839,
-0.04739001393318176,
-0.11555290222167969,
-0.07986609637737274,
0.17682988941669464,
0.0170200914144516,
-0.200240820646286,
0.007432545069605112,
0.000017107597159338184,
0.0180315263569355,
0.1413128525018692,
0.00839243270456791,
0.09298407286405563,
-0.23215584456920624,
-0.002718295669183135,
-0.11714111268520355,
-0.050752025097608566,
0.0475158728659153,
-0.06801366806030273,
0.07884315401315689,
0.17321820557117462,
-0.07994220405817032,
-0.08639270067214966,
-0.20116087794303894,
0.16979865729808807,
0.20369739830493927,
-0.15058687329292297,
0.07667704671621323,
-0.057695209980010986,
-0.17993664741516113,
-0.08295293897390366,
-0.20345759391784668,
-0.00491321599110961,
0.2643989324569702,
-0.11386911571025848,
-0.2649686634540558,
-0.12371411919593811,
-0.30223116278648376,
0.02470102347433567,
0.19716069102287292,
0.10131140053272247,
-0.07247793674468994,
0.14962278306484222,
-0.2147035151720047,
-0.05650762841105461,
-0.1270698457956314,
0.26803824305534363,
0.16226826608181,
0.024357661604881287,
-0.11197848618030548,
0.367327481508255,
0.060884058475494385,
0.10329446941614151,
-0.061729948967695236,
-0.021367602050304413,
0.049967799335718155,
-0.2156446874141693,
0.21699181199073792,
-0.07097310572862625,
0.08892474323511124,
0.0033317597117275,
-0.015547624789178371,
-0.19840079545974731,
-0.06635113060474396,
-0.19390441477298737,
-0.06673640012741089,
-0.03030579909682274,
0.16381798684597015,
0.04855024814605713,
0.32092028856277466,
-0.14751702547073364,
-0.15183177590370178,
-0.06825616955757141,
0.09137443453073502,
-0.06558012962341309,
0.012893499806523323,
-0.12121167778968811,
-0.0652555599808693,
-0.08818940073251724,
0.2411351203918457,
-0.010843249969184399,
0.021586287766695023,
0.18113134801387787,
-0.01647230237722397,
-0.19719941914081573,
-0.07846052944660187,
-0.14050011336803436,
0.012624210678040981,
-0.05051499232649803,
0.015567177906632423,
0.11570568382740021,
0.01869248040020466,
-0.026598410680890083,
0.09697609394788742,
-0.005851348862051964,
0.08523401618003845,
0.04299675673246384,
0.004501747898757458,
0.049876514822244644,
0.14051511883735657,
-0.13821318745613098,
-0.03477935492992401,
-0.10686327517032623,
-0.09812916070222855,
-0.049521271139383316,
0.0712607353925705,
0.07615930587053299,
0.17248402535915375,
0.020141392946243286,
0.07727847993373871,
-0.09949557483196259,
-0.2338399440050125,
0.17602111399173737,
-0.028529275208711624,
0.0397651232779026,
-0.036596037447452545,
-0.007156811188906431,
-0.07959494739770889,
-0.18770985305309296,
0.062017906457185745,
0.08313266187906265,
-0.05678003281354904
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. Disorders with ImidodipeptiduriaImidodipeptiduria has been described in bone disorders, presumably originating from collagen under conditions of high bone turnover.Glycylproline has been found in the urine of:A child with severe bone disease and hyperphosphatasia ;Two sisters with multiple fractures and striking bone deformities of unknown etiology ;A woman age 28 years with osteomalacia and severe hyperparathyroidism who excreted large amounts of glycylproline, equivalent to ~1 g/day ;Three individuals with rickets who excreted decreasing amounts of glycylproline concomitant with clinical improvement, until the imidodipeptiduria disappeared with recovery from the disease.Disorders with Skin UlcersWerner syndrome is characterized by cancer predisposition and the premature appearance of features associated with normal aging. Findings shared by prolidase deficiency and Werner syndrome are chronic lower extremity ulcers , premature graying of the hair, and a "bird-like" facial appearance . Imidodi | [
-0.13030660152435303,
0.178866907954216,
-0.09169072657823563,
-0.11828278005123138,
0.15783575177192688,
0.08852092921733856,
0.12488766759634018,
-0.020342784002423286,
-0.10524696856737137,
-0.17252230644226074,
0.2571409046649933,
0.14761032164096832,
0.1676882952451706,
0.05345159396529198,
-0.16911157965660095,
0.20036502182483673,
0.06620550155639648,
0.04758471995592117,
-0.09014889597892761,
-0.19700364768505096,
0.06092369183897972,
0.007797107566148043,
0.07949932664632797,
0.11098534613847733,
0.06673937290906906,
0.09373753517866135,
0.011537304148077965,
0.131333127617836,
-0.02054581046104431,
0.0029675173573195934,
-0.2690105736255646,
0.08784301578998566,
-0.037600692361593246,
-0.2661430239677429,
0.3165442645549774,
-0.07494336366653442,
-0.18575094640254974,
0.004083343781530857,
0.013563171029090881,
0.06696867942810059,
0.04739869758486748,
-0.0990896224975586,
0.0612969808280468,
-0.052186910063028336,
-0.0033972153905779123,
0.05632978305220604,
-0.15779288113117218,
0.1366465985774994,
-0.0338316336274147,
0.12660551071166992,
0.08883655071258545,
-0.12469995766878128,
0.09180200845003128,
0.021314289420843124,
0.08432622253894806,
-0.21966835856437683,
0.15011218190193176,
0.19653800129890442,
-0.20104525983333588,
0.042524728924036026,
0.15360242128372192,
0.017728440463542938,
-0.006482601631432772,
-0.26560530066490173,
0.09675750881433487,
-0.03196774795651436,
0.044641878455877304,
-0.06799361109733582,
-0.09578685462474823,
0.04331134259700775,
0.38086801767349243,
0.03659173846244812,
0.25133776664733887,
0.07656173408031464,
-0.11113985627889633,
-0.2194080948829651,
0.08847547322511673,
-0.03072761371731758,
0.04338913783431053,
-0.12055134028196335,
-0.26920101046562195,
0.16999652981758118,
0.15227250754833221,
0.04460417851805687,
-0.16141614317893982,
0.21952968835830688,
0.039663296192884445,
0.22202962636947632,
-0.040312036871910095,
0.0338868573307991,
0.15524616837501526,
-0.14014600217342377,
0.09462206065654755,
-0.07695414870977402,
-0.08536887913942337,
-0.14253810048103333,
0.11151546984910965,
-0.014755923300981522,
0.0604405552148819,
0.12383633852005005,
0.18963481485843658,
0.12347353994846344,
-0.039202481508255005,
-0.15835613012313843,
-0.03495097532868385,
0.03410642594099045,
-0.08192764967679977,
-0.18863816559314728,
0.07767893373966217,
0.01765443943440914,
0.13420018553733826,
0.12832848727703094,
0.07672285288572311,
0.04178301990032196,
-0.014417595230042934,
0.03752635046839714,
0.0891241505742073,
-0.17462961375713348,
-0.09596125781536102,
-0.016554925590753555,
0.017097225412726402,
-0.01663452386856079,
-0.04681162163615227,
-0.2838190495967865,
0.18933509290218353,
0.2150242030620575,
0.10333913564682007,
-0.22023546695709229,
0.21513599157333374,
-0.005676101427525282,
-0.038274135440588,
-0.17879286408424377,
0.06593012809753418,
-0.11344482749700546,
-0.08301803469657898,
0.0902252048254013,
-0.2564808428287506,
-0.0927669033408165,
-0.20224927365779877,
0.14406651258468628,
-0.03019828535616398,
0.05828642472624779,
0.27823951840400696,
0.24610599875450134,
-0.0987982526421547,
0.04651924595236778,
0.2528308928012848,
0.04969858005642891,
0.14548690617084503,
-0.012636281549930573,
0.04766511172056198,
-0.10069796442985535,
0.2561410069465637,
-0.06895782053470612,
0.10436110943555832,
0.14491787552833557,
-0.22571294009685516,
0.06750223785638809,
-0.04331794008612633,
0.16436973214149475,
-0.015396667644381523,
-0.08188839256763458,
0.21296338737010956,
-0.27368566393852234,
0.026665138080716133,
0.04903815686702728,
-0.13729219138622284,
-0.05044124275445938,
0.03017539158463478,
0.09786040335893631,
0.022662339732050896,
0.04502376914024353,
-0.15264132618904114,
0.04239384084939957,
0.1603849083185196,
-0.16319455206394196,
0.07663876563310623,
-0.004156854003667831,
-0.18497730791568756,
0.24425363540649414,
0.09651260077953339,
-0.08136963099241257,
-0.036869123578071594,
-0.03379898890852928,
-0.06656667590141296,
-0.1785179078578949,
-0.10711434483528137,
0.2839578092098236,
0.11845972388982773,
0.11018266528844833,
0.1297837346792221,
0.15403170883655548,
-0.012488004751503468,
-0.19978198409080505,
0.19609639048576355,
-0.2199256867170334,
0.02052468992769718,
-0.2270936369895935,
-0.2162451446056366,
0.0855904147028923,
0.25444892048835754,
-0.20411334931850433,
0.03421779349446297,
-0.15699411928653717,
0.004748194012790918,
0.12563996016979218,
0.05568760633468628,
-0.014442919753491879,
0.00441880663856864,
0.26314184069633484,
0.14950299263000488,
0.28628432750701904,
-0.011094396002590656,
0.05527447536587715,
-0.05947640538215637,
0.038905274122953415,
-0.09369198977947235,
-0.11766641587018967,
-0.15406639873981476,
0.1296558678150177,
-0.09456168115139008,
0.002395985182374716,
-0.09543309360742569,
-0.2583003342151642,
-0.12487469613552094,
0.13230115175247192,
-0.06996163725852966,
-0.020816629752516747,
0.1115986630320549,
0.16468359529972076,
-0.02693256363272667,
0.04318208247423172,
0.22685347497463226,
0.04103057086467743,
-0.01700732298195362,
-0.20854470133781433,
-0.027977019548416138,
0.12661617994308472,
-0.02682427689433098,
0.00242519099265337,
-0.25798478722572327,
0.01229319628328085,
-0.117828868329525,
-0.12487777322530746,
-0.10621117800474167,
0.037452299147844315,
-0.05098433047533035,
0.055756136775016785,
-0.10762127488851547,
0.07096727937459946,
-0.13628511130809784,
-0.08574531972408295,
0.2028365433216095,
-0.09946397691965103,
-0.25676801800727844,
-0.0010016725864261389,
0.13731800019741058,
-0.1659543663263321,
0.16485971212387085,
0.16103263199329376,
0.10177046805620193,
0.053297463804483414,
0.223390132188797,
-0.0555395744740963,
-0.15793131291866302,
-0.03402642160654068,
-0.19916276633739471,
0.1850408911705017,
-0.15315194427967072,
-0.2509303390979767,
0.029533626511693,
-0.09462093561887741,
0.2708970010280609,
0.07411421090364456,
-0.12610290944576263,
-0.13919511437416077,
-0.18763568997383118,
0.00612008199095726,
0.14204223453998566,
-0.18770688772201538,
0.05723177641630173,
0.049864497035741806,
-0.1461356282234192,
-0.14180347323417664,
0.3197159171104431,
0.08187577873468399,
-0.05169651657342911,
0.19737963378429413,
-0.10116858035326004,
0.043639425188302994,
0.07064678519964218,
0.19968076050281525,
-0.008839874528348446,
-0.07644243538379669,
0.029406297951936722,
-0.01690358854830265,
0.07955031841993332,
-0.13056091964244843,
0.025720154866576195,
-0.02736298181116581,
0.33063483238220215,
0.1212979257106781,
-0.0006380326813086867,
0.0032473483588546515,
-0.1502130776643753,
-0.20402798056602478,
0.04185771569609642,
-0.07239413261413574,
-0.22670194506645203,
-0.0717453807592392,
-0.1957274228334427,
-0.025940362364053726,
-0.07261216640472412,
0.025889048352837563,
0.020445210859179497,
-0.08716422319412231,
-0.29924020171165466,
-0.06852664798498154,
-0.09986786544322968,
0.04451466724276543,
0.15514159202575684,
-0.05037631466984749,
-0.005939006339758635,
0.2619419991970062,
0.12847943603992462,
0.06924400478601456,
-0.11785930395126343,
0.04466758668422699,
-0.16695919632911682,
-0.03418383002281189,
0.1579148769378662,
0.062282394617795944,
-0.040846940129995346,
-0.11496556550264359,
-0.07428177446126938,
0.12952692806720734,
0.08693461865186691,
0.046820998191833496,
-0.19748151302337646,
-0.14188480377197266,
0.0399419404566288,
-0.3595111072063446,
0.07775659114122391,
-0.07177971303462982,
-0.09054146707057953,
0.010384300723671913,
0.21221934258937836,
0.21372246742248535,
0.22491410374641418,
-0.21488939225673676,
-0.09196843206882477,
0.013367320410907269,
0.21433749794960022,
0.02239050716161728,
-0.0956064835190773,
-0.06693984568119049,
-0.2512420117855072,
0.08684057742357254,
0.21467790007591248,
-0.20187683403491974,
-0.01686524972319603,
0.20417281985282898,
0.08616963773965836,
-0.23433423042297363,
0.23114362359046936,
0.1134774312376976,
-0.03775593638420105,
-0.1234416514635086,
0.13995839655399323,
-0.03409646078944206,
0.027359697967767715,
-0.1713045835494995,
0.08697232604026794,
0.030383657664060593,
-0.27259957790374756,
-0.02740292437374592,
-0.19630005955696106,
0.14725156128406525,
-0.017855122685432434,
-0.019470561295747757,
-0.10979514569044113,
0.08375639468431473,
0.06401854008436203,
0.1445273756980896,
-0.0753864049911499,
0.11360733211040497,
-0.15713675320148468,
0.05343205854296684,
0.008915847167372704,
-0.03997470438480377,
0.211246058344841,
0.04338885471224785,
0.02980087697505951,
0.0621141754090786,
-0.09347806870937347,
0.1483052670955658,
-0.08494522422552109,
0.020589543506503105,
-0.2503098249435425,
0.00870008859783411,
0.09791024029254913,
0.03580997511744499,
0.12440367043018341,
0.22420808672904968,
0.1390484720468521,
0.180434912443161,
-0.03047061897814274,
0.0903889462351799,
-0.032483115792274475,
0.05610756576061249,
-0.03726590424776077,
0.10890891402959824,
0.040968041867017746,
-0.1401062160730362,
0.05170457810163498,
-0.011777765117585659,
0.016090795397758484,
0.10065704584121704,
-0.031584277749061584,
0.07424402981996536,
-0.14967700839042664,
-0.30724385380744934,
0.06851435452699661,
-0.04510652646422386,
-0.09505048394203186,
-0.12972645461559296,
-0.11022967100143433,
-0.017612475901842117,
-0.03381526470184326,
0.10525836050510406,
-0.012767709791660309,
-0.10882768779993057,
0.03868703916668892,
-0.07856771349906921,
0.1503373682498932,
-0.08743564039468765,
-0.06669022142887115,
-0.03755725920200348,
0.2505626380443573,
0.10789012163877487,
0.3532867729663849,
-0.3138895630836487,
-0.1318156123161316,
-0.07334312051534653,
0.006744577549397945,
0.07089690119028091,
-0.1283499002456665,
0.0874863862991333,
0.05371228978037834,
0.014507350511848927,
0.029219068586826324,
-0.03400799632072449,
0.29792141914367676,
-0.059150658547878265,
-0.26533472537994385,
-0.10577664524316788,
-0.07418016344308853,
-0.17175361514091492,
0.0063132005743682384,
0.13906264305114746,
0.02424055151641369,
0.013720596209168434,
-0.08398359268903732,
-0.26460257172584534,
0.06648330390453339,
0.423508882522583,
-0.2508242726325989,
0.15204674005508423,
0.047364987432956696,
-0.018547888845205307,
0.03199470788240433,
0.05786097049713135,
-0.057291533797979355,
0.040127694606781006,
-0.13556747138500214,
-0.07169771939516068,
-0.060716208070516586,
0.1325426697731018,
-0.20129847526550293,
0.19872982800006866,
-0.051887039095163345,
0.12662261724472046,
-0.18143096566200256,
0.06796558946371078,
0.1087610125541687,
-0.10280681401491165,
0.14579921960830688,
-0.10580471903085709,
0.23899565637111664,
0.111964650452137,
0.09533019363880157,
0.11523154377937317,
0.1311059445142746,
0.23102949559688568,
0.029556158930063248,
0.1718159019947052,
0.024783801287412643,
-0.20641490817070007,
0.026419105008244514,
-0.33131518959999084,
0.05223673954606056,
-0.17759859561920166,
0.06543408334255219,
-0.020870598033070564,
0.20891733467578888,
-0.0730457603931427,
0.15979263186454773,
-0.13981258869171143,
0.06475036591291428,
0.15618179738521576,
0.1321856528520584,
-0.02852277271449566,
-0.34636130928993225,
-0.19385795295238495,
0.035813409835100174,
0.04875557869672775,
0.07226329296827316,
0.1756427139043808,
0.11639568209648132,
-0.10786337405443192,
-0.029685961082577705,
-0.1238107681274414,
0.00839335098862648,
0.17260877788066864,
-0.11976725608110428,
-0.11744385957717896,
0.16835802793502808,
-0.003659564536064863,
-0.036918576806783676,
-0.1208556741476059,
0.004637611098587513,
-0.05591864138841629,
-0.010515116155147552,
-0.09270388633012772,
0.10353697836399078,
0.014680548571050167,
-0.11282055079936981,
-0.021394982933998108,
0.13286876678466797,
0.14190791547298431,
0.013233819976449013,
0.02729744464159012,
-0.035381972789764404,
0.287539541721344,
-0.1186964213848114,
0.06586845219135284,
0.022304635494947433,
-0.16656340658664703,
-0.054013676941394806,
0.04710911959409714,
-0.11865177750587463,
0.09243705868721008,
0.019100425764918327,
0.05366061255335808,
-0.07227053493261337,
-0.0363677516579628,
0.1225644126534462,
-0.01996467635035515,
0.008185566402971745,
0.042795512825250626,
0.09353833645582199,
0.16574141383171082,
0.03856758028268814,
-0.11286001652479172,
-0.03136162832379341,
0.14792492985725403,
-0.07666217535734177,
0.058520298451185226,
-0.29840710759162903,
-0.18241144716739655,
-0.030043823644518852,
-0.021434808149933815,
-0.08719924837350845,
-0.26008090376853943,
-0.18648935854434967,
-0.22648195922374725,
-0.2505306005477905,
-0.008331215009093285,
-0.04677826166152954,
0.09073249250650406,
-0.04663816839456558,
0.028589630499482155,
0.034522105008363724,
0.016812393441796303,
0.08469545096158981,
-0.02643781155347824,
-0.048358168452978134,
0.17644190788269043,
0.2240234762430191,
-0.014343762770295143,
0.238838791847229,
-0.038961268961429596,
-0.01622772216796875,
-0.19221755862236023,
0.11974173039197922,
0.049722298979759216,
0.10442043095827103,
-0.17069464921951294,
0.21149830520153046,
0.1535651832818985,
0.005984951741993427,
-0.047816645354032516,
-0.14895185828208923,
-0.15550895035266876,
-0.02287820167839527,
0.06896192580461502,
0.08620277047157288,
-0.18589787185192108,
0.14962418377399445,
0.08136168867349625,
0.20651759207248688,
-0.0730704665184021,
-0.05040683597326279,
0.06276202201843262,
0.37639355659484863,
-0.1316291093826294,
0.04645193740725517,
-0.161263108253479,
-0.07116778939962387,
-0.04098409041762352,
0.22695544362068176,
0.19733239710330963,
0.09893037378787994,
-0.1909322291612625,
0.032602861523628235,
0.1741548776626587,
0.1589844971895218,
-0.054931268095970154,
0.05951180309057236,
0.009425240568816662,
-0.003896152600646019,
-0.11566810309886932,
-0.06036890298128128,
0.040417421609163284,
-0.1646759808063507,
0.17580801248550415,
-0.01308688148856163,
0.16877375543117523,
-0.039320945739746094,
-0.0023682836908847094,
-0.044579021632671356,
-0.01492240745574236,
-0.12345784157514572,
0.08270581066608429,
-0.03358425572514534,
0.2052309513092041,
-0.05958714708685875,
0.03331828862428665,
0.011621926911175251,
-0.17430442571640015,
0.16234153509140015,
-0.0008369619026780128,
-0.12657125294208527,
-0.08626243472099304,
0.03406423330307007,
-0.05751676484942436,
0.18622957170009613,
0.06402602791786194,
0.07626711577177048,
-0.2482614368200302,
-0.12653470039367676,
-0.15151019394397736,
-0.12222327291965485,
0.02525331825017929,
-0.023221610113978386,
0.10536616295576096,
0.13423563539981842,
-0.0783008262515068,
-0.194335475564003,
-0.09423608332872391,
0.0789148360490799,
0.26431527733802795,
-0.12463832646608353,
-0.0013074952876195312,
-0.06320717930793762,
-0.09305737167596817,
0.010134181939065456,
-0.42705920338630676,
-0.06700266152620316,
0.2289552539587021,
-0.10846693068742752,
-0.2240230143070221,
-0.12354626506567001,
-0.13877025246620178,
0.06126446649432182,
0.07366691529750824,
0.04956630989909172,
0.0272960402071476,
0.1086590513586998,
-0.1674777716398239,
-0.19559796154499054,
-0.027125056833028793,
0.18881359696388245,
-0.09004279226064682,
0.025893496349453926,
-0.02232843078672886,
0.4273165166378021,
-0.03426908701658249,
0.08159331232309341,
-0.12060437351465225,
-0.06135000288486481,
0.09814374893903732,
-0.28723037242889404,
0.1634647101163864,
0.12379605323076248,
0.039121732115745544,
0.016298331320285797,
-0.11043872684240341,
-0.06336649507284164,
-0.057594917714595795,
0.027020927518606186,
0.15740220248699188,
-0.16295212507247925,
0.12416566163301468,
0.1814190149307251,
0.1958882212638855,
-0.18349730968475342,
-0.17672015726566315,
-0.009804438799619675,
0.05101319029927254,
-0.07890217751264572,
-0.04461456090211868,
-0.09440163522958755,
0.03467303514480591,
-0.07134731113910675,
0.15842042863368988,
0.04135119169950485,
-0.10445448756217957,
0.16522902250289917,
-0.1749083548784256,
-0.11980969458818436,
-0.10021036118268967,
-0.021148987114429474,
0.08740828186273575,
0.026279212906956673,
-0.09561987221240997,
0.12843811511993408,
-0.06395196914672852,
-0.061382971704006195,
-0.016544867306947708,
0.0708913654088974,
0.04996126517653465,
0.019069887697696686,
0.13712497055530548,
-0.002206985605880618,
0.04819793254137039,
-0.16366484761238098,
0.0074177575297653675,
-0.018166564404964447,
-0.12950779497623444,
-0.013375225476920605,
0.04634552076458931,
0.1064203754067421,
0.19937758147716522,
0.029893793165683746,
-0.06477642804384232,
-0.2427949756383896,
-0.1820119470357895,
0.15825113654136658,
-0.004709991160780191,
0.040727656334638596,
-0.0793212354183197,
-0.07297395169734955,
-0.12602615356445312,
-0.1850534826517105,
-0.022582150995731354,
-0.05353289097547531,
0.1369740515947342
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. ~1 g/day ;Three individuals with rickets who excreted decreasing amounts of glycylproline concomitant with clinical improvement, until the imidodipeptiduria disappeared with recovery from the disease.Disorders with Skin UlcersWerner syndrome is characterized by cancer predisposition and the premature appearance of features associated with normal aging. Findings shared by prolidase deficiency and Werner syndrome are chronic lower extremity ulcers , premature graying of the hair, and a "bird-like" facial appearance . Imidodipeptiduria has not been reported in Werner syndrome. Werner syndrome is caused by biallelic pathogenic variants in WRN and inherited in an autosomal recessive manner.Sickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. Leg ulcers which are relatively common in SCD were found in 2.5% of patients from the Cooperative Study of Sickle Cell Disease in the US , in 43% in the Jamaican | [
-0.23646552860736847,
0.028160113841295242,
0.02513263188302517,
-0.17137031257152557,
-0.007072456646710634,
0.07525002956390381,
-0.01605968363583088,
0.004850142169743776,
-0.19640229642391205,
-0.0909281075000763,
0.21968992054462433,
0.020832426846027374,
0.1496412456035614,
0.09793544560670853,
-0.2872759699821472,
0.30889782309532166,
-0.1854356974363327,
0.17056797444820404,
-0.03753213584423065,
-0.17291200160980225,
-0.15148872137069702,
-0.061149463057518005,
0.09941462427377701,
0.16604246199131012,
-0.08690610527992249,
-0.22970429062843323,
0.16166268289089203,
0.25322362780570984,
-0.046205248683691025,
0.1819143295288086,
-0.0714598074555397,
0.1837889552116394,
-0.11735604703426361,
-0.19934259355068207,
0.08756491541862488,
-0.07356172800064087,
-0.3662380576133728,
0.03660363331437111,
0.143822580575943,
0.13480821251869202,
-0.019725706428289413,
-0.08064272254705429,
-0.076616071164608,
0.06645773351192474,
0.05780337378382683,
0.0025328847113996744,
-0.10970361530780792,
0.09566458314657211,
0.007956113666296005,
0.28822192549705505,
-0.05883351340889931,
0.05695141479372978,
0.09323827922344208,
0.0896221324801445,
0.2253594845533371,
-0.134766086935997,
-0.035192932933568954,
0.2768171429634094,
-0.2505415976047516,
0.0016141110099852085,
0.29219093918800354,
-0.06800509244203568,
0.11442265659570694,
-0.24655044078826904,
0.04484033212065697,
0.0018636391032487154,
-0.07827814668416977,
0.0037181030493229628,
0.11738638579845428,
0.07466038316488266,
0.17612086236476898,
-0.046829771250486374,
0.20891737937927246,
0.002709253691136837,
-0.02670372650027275,
-0.16371053457260132,
0.24427635967731476,
-0.06356435269117355,
0.11893656104803085,
-0.2865212559700012,
-0.12150710076093674,
-0.027162278071045876,
0.035796262323856354,
0.16152377426624298,
-0.06093659624457359,
-0.01362469233572483,
-0.062206167727708817,
-0.04670677334070206,
0.012385775335133076,
0.05367157608270645,
0.150990292429924,
-0.15859349071979523,
-0.11369647085666656,
0.08520171046257019,
-0.09284333139657974,
-0.009251048788428307,
-0.027638457715511322,
-0.2744309604167938,
0.10975323617458344,
0.11488771438598633,
0.29111209511756897,
-0.06076006218791008,
-0.023640140891075134,
-0.09443257004022598,
-0.0006351930787786841,
0.010215927846729755,
0.07278458029031754,
-0.054795004427433014,
-0.049006130546331406,
0.15336903929710388,
0.13739794492721558,
0.21258367598056793,
-0.0868544802069664,
-0.07437623292207718,
0.03555969148874283,
-0.04471295699477196,
-0.006755730137228966,
-0.026334259659051895,
-0.0010372025426477194,
-0.005995098501443863,
0.061456020921468735,
-0.11247621476650238,
-0.09905728697776794,
-0.24170251190662384,
0.15474990010261536,
0.15119294822216034,
0.03746190667152405,
-0.2688012719154358,
0.1045425683259964,
0.04251673072576523,
-0.08219855278730392,
-0.16995292901992798,
-0.04621134325861931,
-0.10404213517904282,
-0.053319405764341354,
0.04032514616847038,
-0.18864043056964874,
-0.10267096757888794,
-0.3399958610534668,
-0.04224191978573799,
0.04723771661520004,
0.04747847095131874,
0.3082680106163025,
0.2760908305644989,
-0.30380532145500183,
-0.07646840065717697,
0.36798790097236633,
-0.07220610976219177,
-0.01761537231504917,
-0.17396846413612366,
0.08485423028469086,
-0.06618860363960266,
0.3149992823600769,
-0.05395292118191719,
-0.17837440967559814,
0.05986270681023598,
-0.1310010850429535,
0.1972712129354477,
-0.17221857607364655,
0.04507889598608017,
0.07718192040920258,
-0.03287963569164276,
0.11262274533510208,
-0.31016805768013,
0.06489014625549316,
0.09799932688474655,
-0.019557900726795197,
-0.06230846047401428,
0.0011726496741175652,
-0.003271059598773718,
0.1389690488576889,
0.038125619292259216,
0.006567934062331915,
-0.031245708465576172,
0.054921384900808334,
0.11049209535121918,
-0.08882477879524231,
-0.07732529938220978,
-0.12556207180023193,
0.04461517184972763,
0.030767865478992462,
-0.09640859067440033,
0.0018040129216387868,
-0.18113435804843903,
-0.08426490426063538,
-0.08672744035720825,
-0.016002951189875603,
0.31524139642715454,
-0.21946725249290466,
0.010416117496788502,
0.2759585976600647,
0.042779888957738876,
-0.012554093264043331,
-0.14041447639465332,
0.06531967967748642,
-0.17537225782871246,
-0.17183227837085724,
-0.10353691130876541,
-0.1514645516872406,
0.05370394513010979,
0.19737063348293304,
-0.1768215000629425,
-0.14617137610912323,
-0.11510974168777466,
-0.02767961099743843,
-0.08968379348516464,
-0.14721153676509857,
0.020986095070838928,
-0.040399596095085144,
0.25279945135116577,
0.18641674518585205,
0.3510666787624359,
-0.07394392788410187,
-0.032958947122097015,
-0.10100394487380981,
0.12224440276622772,
-0.06961715221405029,
-0.20042701065540314,
0.05016658827662468,
0.03920711576938629,
-0.1780289262533188,
-0.0018420945852994919,
0.07102987170219421,
-0.4261506497859955,
-0.152133047580719,
0.08905356377363205,
-0.01990359276533127,
-0.03386938199400902,
0.037321608513593674,
0.12181918323040009,
-0.02046060562133789,
0.08438108116388321,
-0.005481320433318615,
-0.1519613116979599,
0.12053684890270233,
-0.0066273827105760574,
-0.022120311856269836,
0.16451036930084229,
0.001481040962971747,
-0.0030142103787511587,
-0.064467653632164,
0.1879427582025528,
0.06553980708122253,
-0.0013434524880722165,
-0.14074398577213287,
0.1183701604604721,
-0.13262136280536652,
0.09182555973529816,
-0.02336702309548855,
0.01658039726316929,
-0.03361622244119644,
-0.2179414927959442,
0.14364725351333618,
0.08599553257226944,
-0.3024066686630249,
-0.14921319484710693,
0.07844709604978561,
-0.11661326140165329,
0.14342455565929413,
0.11778859049081802,
0.3605341613292694,
0.09473397582769394,
0.10080332309007645,
-0.10388727486133575,
-0.19609512388706207,
-0.07931643724441528,
-0.24543316662311554,
0.15470808744430542,
-0.04530736058950424,
-0.2228214591741562,
-0.04949117451906204,
0.22374923527240753,
0.17209133505821228,
-0.007834067568182945,
-0.24132078886032104,
-0.04620066657662392,
-0.22360022366046906,
0.08780571818351746,
0.03413472697138786,
-0.016275299713015556,
0.014034785330295563,
-0.05454735457897186,
0.07851859927177429,
-0.2372036576271057,
0.26434099674224854,
-0.20766356587409973,
-0.09798074513673782,
0.03945084288716316,
-0.026261458173394203,
0.005492123309522867,
-0.19148589670658112,
0.25297027826309204,
-0.1239786446094513,
0.006495308596640825,
0.29032060503959656,
0.020391268655657768,
0.16098318994045258,
-0.20033575594425201,
-0.05732076242566109,
-0.1460598111152649,
0.31310880184173584,
0.11788751929998398,
0.008584537543356419,
-0.04168296232819557,
-0.156898632645607,
-0.28603172302246094,
0.1107339859008789,
-0.00904859323054552,
-0.09209152311086655,
0.07108303904533386,
-0.27558791637420654,
0.16277310252189636,
0.053910769522190094,
0.172721266746521,
-0.24861732125282288,
-0.13201531767845154,
-0.30502304434776306,
-0.019094938412308693,
-0.08608952164649963,
0.03409598767757416,
0.07164114713668823,
0.06909837573766708,
0.06078852713108063,
0.16245204210281372,
0.08511427044868469,
-0.1675548553466797,
-0.03265216946601868,
0.06658856570720673,
-0.2402605265378952,
0.10255096107721329,
0.05806773528456688,
0.02146761305630207,
-0.01639600470662117,
0.05448756739497185,
-0.08688762784004211,
-0.03181183338165283,
-0.135397270321846,
-0.0587165467441082,
-0.37029048800468445,
-0.1802321821451187,
-0.1308317482471466,
-0.35202157497406006,
0.1937303990125656,
0.03419075161218643,
-0.11339447647333145,
0.03207271173596382,
0.3093438744544983,
0.19846111536026,
0.05160904675722122,
-0.2676011025905609,
-0.025461239740252495,
-0.10313786566257477,
0.14643192291259766,
0.1817859411239624,
-0.08933715522289276,
-0.16384316980838776,
-0.23552526533603668,
0.07508955150842667,
0.10661618411540985,
-0.08277185261249542,
-0.11521551012992859,
0.19419553875923157,
-0.0698433443903923,
-0.17894302308559418,
0.09589919447898865,
0.075419582426548,
-0.05821044370532036,
-0.007224450819194317,
0.1646043062210083,
-0.04770699888467789,
0.20401531457901,
0.054309528321027756,
0.07417932152748108,
-0.10908821225166321,
-0.27649420499801636,
-0.028555763885378838,
-0.42446213960647583,
0.10217362642288208,
-0.06229991465806961,
-0.021234598010778427,
-0.023631643503904343,
0.06268636882305145,
0.12986701726913452,
0.009035310707986355,
-0.05824872851371765,
0.18079204857349396,
-0.2337287813425064,
0.26548734307289124,
-0.07977128028869629,
0.026609787717461586,
0.3123166263103485,
0.16583622992038727,
0.034358348697423935,
-0.09566561877727509,
-0.0949094146490097,
0.050354402512311935,
0.05648880824446678,
0.00606332765892148,
-0.17887260019779205,
-0.15125824511051178,
-0.07839780300855637,
-0.05872504785656929,
0.1471361219882965,
0.06874380260705948,
0.12001287937164307,
-0.022115284577012062,
0.04627618566155434,
0.09676072746515274,
-0.23250362277030945,
0.06661493331193924,
-0.1805734634399414,
0.0881335660815239,
0.2092863768339157,
-0.09455730766057968,
0.07927540689706802,
-0.14136239886283875,
0.07177426666021347,
0.12797419726848602,
0.09132175147533417,
-0.0041013676673173904,
-0.08043740689754486,
-0.1619679480791092,
0.07287757843732834,
-0.1920596957206726,
0.15819214284420013,
-0.06584333628416061,
-0.0016743805026635528,
-0.055244557559490204,
-0.1988372653722763,
-0.10597993433475494,
0.005596559029072523,
-0.203558549284935,
-0.12436266243457794,
-0.1427840292453766,
0.2953184247016907,
-0.08275245130062103,
0.06687670946121216,
-0.009267942048609257,
0.28489938378334045,
0.016526514664292336,
0.40535807609558105,
-0.07100017368793488,
-0.06644707918167114,
-0.005237930454313755,
0.11513542383909225,
0.1797829419374466,
-0.24061483144760132,
0.0475502610206604,
-0.04485970735549927,
0.0055951448157429695,
0.029443660750985146,
0.07831718027591705,
0.172646164894104,
0.012930919416248798,
-0.2826525568962097,
0.015074169263243675,
0.08156613260507584,
-0.042687252163887024,
0.0638795793056488,
0.050500161945819855,
0.08361857384443283,
0.08631296455860138,
-0.03212203085422516,
-0.12172848731279373,
0.038991738110780716,
0.3241024613380432,
-0.3247373402118683,
0.11720867455005646,
0.14689435064792633,
0.1639031022787094,
0.10743262618780136,
0.06811124086380005,
0.06558455526828766,
0.03125132992863655,
-0.12490464001893997,
-0.006025203503668308,
0.011403713375329971,
0.09496665745973587,
-0.13999851047992706,
0.15167412161827087,
0.043059881776571274,
0.009225164540112019,
-0.10967820137739182,
0.02256297878921032,
0.0035538177471607924,
0.006795779801905155,
0.12452762573957443,
-0.1715155392885208,
0.26533278822898865,
-0.19767290353775024,
-0.21884585916996002,
-0.05460575222969055,
0.12485606223344803,
0.26257890462875366,
-0.1325238198041916,
0.10681384801864624,
-0.03716708719730377,
-0.22000010311603546,
-0.0035531381145119667,
-0.3576340675354004,
0.0006223503150977194,
-0.004149148240685463,
0.23649775981903076,
0.03769431263208389,
0.25029394030570984,
-0.023877974599599838,
0.01902417466044426,
-0.33046698570251465,
0.09384678304195404,
0.11400709301233292,
-0.08923782408237457,
-0.019992360845208168,
-0.13670924305915833,
-0.35432228446006775,
0.11830923706293106,
0.1623530238866806,
-0.03995789587497711,
0.21105749905109406,
0.2108370065689087,
-0.1839396208524704,
0.00891265831887722,
-0.06545142829418182,
0.05362088233232498,
0.1246359720826149,
-0.19629798829555511,
-0.07003763318061829,
0.00047091388842090964,
0.05707592889666557,
-0.03401549533009529,
-0.07706756144762039,
-0.12050087004899979,
-0.1425533890724182,
-0.038855742663145065,
-0.017796222120523453,
0.06823311001062393,
0.009925982914865017,
-0.031207570806145668,
0.10521071404218674,
-0.04659387469291687,
0.17801141738891602,
-0.12665371596813202,
0.085685595870018,
0.052291389554739,
0.27825477719306946,
-0.06252177804708481,
0.04023917764425278,
0.11861763149499893,
-0.054352909326553345,
-0.16550911962985992,
-0.0012505314080044627,
-0.10033278912305832,
0.09751713275909424,
0.25164681673049927,
-0.07446227222681046,
-0.22177693247795105,
-0.12717457115650177,
-0.017032276839017868,
0.1580674648284912,
0.040416307747364044,
0.16852229833602905,
0.08330225199460983,
0.03475964069366455,
-0.04669759050011635,
-0.1509283483028412,
0.08630786836147308,
0.0741300880908966,
0.23249788582324982,
0.0983937680721283,
-0.20640067756175995,
-0.0054831113666296005,
-0.03382016345858574,
-0.04517615959048271,
-0.046119291335344315,
-0.2579604387283325,
-0.06638460606336594,
-0.1848919540643692,
-0.2595270276069641,
0.10454186797142029,
-0.14998233318328857,
0.03748510777950287,
0.2960717976093292,
-0.02322809211909771,
0.018956052139401436,
-0.0740986093878746,
-0.18214921653270721,
0.07711707800626755,
-0.09652348607778549,
0.37414664030075073,
0.03087129257619381,
0.06552167236804962,
-0.004794197157025337,
-0.07634871453046799,
-0.16363117098808289,
-0.09180060774087906,
0.18509651720523834,
0.0859861969947815,
0.18952950835227966,
-0.14758504927158356,
0.0796203464269638,
0.06334348022937775,
-0.04884835705161095,
0.20592740178108215,
0.09108657389879227,
-0.04590083286166191,
0.12851226329803467,
-0.017187442630529404,
0.1396416574716568,
-0.09862417727708817,
0.20456641912460327,
-0.11472893506288528,
0.0818818211555481,
-0.07528480142354965,
-0.14029638469219208,
-0.052487704902887344,
0.29763439297676086,
-0.10722625255584717,
0.00009529280214337632,
-0.1971309334039688,
-0.09975450485944748,
0.03480331599712372,
0.22494859993457794,
0.19659428298473358,
0.015220828354358673,
-0.1616813689470291,
0.1864434778690338,
0.1525053083896637,
0.17463716864585876,
-0.0611409917473793,
0.17632246017456055,
-0.04800644889473915,
-0.055457644164562225,
-0.165737584233284,
0.20991471409797668,
-0.05458493530750275,
-0.14750894904136658,
0.06469003111124039,
-0.0892895832657814,
-0.04163520783185959,
0.11317645013332367,
0.0629076436161995,
-0.2693800628185272,
-0.0028121599461883307,
0.0030404890421777964,
0.051798079162836075,
0.08472322672605515,
0.024491041898727417,
0.05081682652235031,
0.043604087084531784,
0.23555545508861542,
-0.019377674907445908,
0.139858677983284,
-0.0057913693599402905,
-0.009254512377083302,
-0.12336666136980057,
-0.05263792723417282,
-0.15319043397903442,
0.18418875336647034,
-0.11541292816400528,
0.0006209940183907747,
-0.15143729746341705,
-0.1980426162481308,
0.005808244459331036,
-0.19486592710018158,
0.14715014398097992,
-0.00013805972412228584,
-0.049932707101106644,
0.08520769327878952,
-0.1903972625732422,
-0.1925673633813858,
-0.07019142806529999,
0.05201620236039162,
0.4067888557910919,
-0.05582937225699425,
-0.11744297295808792,
0.04164528474211693,
0.10653147101402283,
-0.037399258464574814,
-0.23760966956615448,
-0.2149810940027237,
0.10953915119171143,
-0.14061079919338226,
-0.2516329288482666,
-0.002208505989983678,
0.06379320472478867,
0.08985327929258347,
-0.016941942274570465,
-0.22646218538284302,
0.03627436235547066,
0.05718257278203964,
-0.09540687501430511,
-0.2286655157804489,
-0.019705912098288536,
0.10428838431835175,
0.03738492354750633,
-0.018546707928180695,
-0.029990820214152336,
0.3268052935600281,
0.14055384695529938,
0.024753957986831665,
-0.2308899313211441,
-0.09133754670619965,
0.0951918512582779,
-0.10693209618330002,
0.1143876239657402,
0.14733447134494781,
0.05014459788799286,
0.13938835263252258,
-0.062194809317588806,
-0.10224350541830063,
0.09820324182510376,
0.18826372921466827,
0.18950504064559937,
-0.16383367776870728,
0.0424891896545887,
0.08323957026004791,
-0.04270921275019646,
-0.19126643240451813,
0.01950821839272976,
0.0633080005645752,
0.0728568285703659,
0.2704032063484192,
0.16199536621570587,
0.07913333177566528,
-0.027741694822907448,
-0.07710859179496765,
0.06293471157550812,
0.028405753895640373,
-0.07689502090215683,
0.17813505232334137,
-0.18764805793762207,
-0.04368666186928749,
-0.21800120174884796,
0.060754645615816116,
0.1262093037366867,
-0.14001794159412384,
-0.09235884249210358,
0.15579301118850708,
-0.11589004844427109,
-0.07095664739608765,
-0.07050619274377823,
0.0985991433262825,
0.14118973910808563,
0.016462916508316994,
0.13905248045921326,
0.05542504042387009,
0.2371569722890854,
0.004068615846335888,
0.05305204167962074,
0.10051514953374863,
-0.21395981311798096,
0.2178056389093399,
0.08045586198568344,
0.13698934018611908,
0.07417649775743484,
-0.04829654097557068,
-0.15908382833003998,
-0.18801414966583252,
-0.08838619291782379,
0.143929585814476,
0.23298804461956024,
0.011685831472277641,
-0.08432134985923767,
-0.05281345546245575,
-0.09453190118074417,
-0.39028647541999817,
-0.11294430494308472,
-0.010912182740867138,
0.30677923560142517
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. " facial appearance . Imidodipeptiduria has not been reported in Werner syndrome. Werner syndrome is caused by biallelic pathogenic variants in WRN and inherited in an autosomal recessive manner.Sickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. Leg ulcers which are relatively common in SCD were found in 2.5% of patients from the Cooperative Study of Sickle Cell Disease in the US , in 43% in the Jamaican Cohort Study , and in 1.7% to 13.2% of Africans.Although urinary excretion of hydroxyproline has been shown to be significantly increased in persons with sickle cell disease compared to controls (presumably due to bone involvement), glycylprolinuria has not been reported in SCD. More importantly, although individuals with prolidase deficiency can have mild findings of hemolysis, they do not have veno-occlusive episodes. SCD is caused by biallelic pathogenic variants | [
-0.21393270790576935,
-0.06511984020471573,
-0.14920958876609802,
-0.07792005687952042,
-0.14446549117565155,
0.21559062600135803,
0.05874696001410484,
-0.09281260520219803,
-0.2889738976955414,
-0.1467377245426178,
0.15371212363243103,
0.04940669983625412,
0.1557294875383377,
0.16218262910842896,
-0.2087351381778717,
0.3494124412536621,
-0.02030445635318756,
0.2747570872306824,
-0.030760426074266434,
-0.15673516690731049,
-0.27554312348365784,
0.02369653806090355,
0.19926698505878448,
0.2274606078863144,
0.06296629458665848,
-0.18621644377708435,
0.1491425335407257,
0.12710228562355042,
-0.17204649746418,
0.18186470866203308,
-0.1030256524682045,
-0.0733465850353241,
0.19164244830608368,
-0.33570781350135803,
0.14799799025058746,
-0.011150502599775791,
-0.2656170129776001,
0.061722900718450546,
0.24761298298835754,
0.08807291090488434,
0.017531033605337143,
-0.044201888144016266,
0.12798167765140533,
0.13406328856945038,
0.02367897517979145,
0.08964969962835312,
-0.07922554761171341,
0.2079099863767624,
-0.16304928064346313,
0.401510089635849,
0.08398053050041199,
0.12085475027561188,
-0.04390595108270645,
0.039998967200517654,
0.1145898848772049,
-0.1658353954553604,
-0.15131141245365143,
0.2558661997318268,
-0.14351345598697662,
-0.09129255264997482,
0.09142858535051346,
-0.1864888221025467,
0.11736803501844406,
-0.3862423002719879,
0.21084460616111755,
-0.12193771451711655,
-0.05549503490328789,
-0.1854068785905838,
0.08015675842761993,
0.09188639372587204,
0.4564856290817261,
-0.14825479686260223,
0.23900814354419708,
0.09193608164787292,
-0.1466675102710724,
-0.17562465369701385,
0.1668812483549118,
-0.27308011054992676,
-0.002149950945749879,
-0.26138177514076233,
-0.13512280583381653,
-0.013589445501565933,
0.06340955197811127,
-0.0026668005157262087,
-0.18981988728046417,
0.09071771055459976,
-0.10798992216587067,
0.031170817092061043,
-0.1118142157793045,
0.28816795349121094,
0.26709502935409546,
-0.13473114371299744,
-0.07460211962461472,
0.32736650109291077,
-0.11394652724266052,
0.04429472237825394,
0.03360305726528168,
-0.25152266025543213,
0.06419110298156738,
0.15347224473953247,
0.2810707986354828,
0.12007107585668564,
-0.1993730068206787,
0.022008664906024933,
0.05280879884958267,
0.17100781202316284,
-0.03473091870546341,
-0.09156258404254913,
-0.18767088651657104,
0.17071977257728577,
0.2589959502220154,
0.0037057718727737665,
0.00503896689042449,
-0.18762272596359253,
0.03380286693572998,
-0.012585329823195934,
0.02009033039212227,
0.1565161645412445,
-0.12636110186576843,
-0.15267230570316315,
-0.0288397166877985,
-0.04857499897480011,
0.01653989404439926,
-0.1998519003391266,
0.10718078911304474,
0.18602345883846283,
0.21766306459903717,
-0.13222146034240723,
0.13112445175647736,
-0.038368768990039825,
0.11929020285606384,
-0.15043732523918152,
-0.03731904551386833,
-0.1877385675907135,
-0.10732164978981018,
0.004137944430112839,
-0.10541331022977829,
0.09166816622018814,
-0.2440103143453598,
-0.002261596266180277,
-0.05954373627901077,
0.004692321643233299,
0.2384510636329651,
0.3444080054759979,
-0.1837129294872284,
-0.06367381662130356,
0.3107253611087799,
-0.15092232823371887,
-0.01858297362923622,
-0.18951942026615143,
0.2114844024181366,
-0.06753601878881454,
0.28752756118774414,
-0.17302949726581573,
-0.01984786055982113,
0.08986746519804001,
-0.15349367260932922,
0.17006345093250275,
-0.1792651265859604,
-0.1866386979818344,
0.1964898407459259,
-0.10888940840959549,
0.04072335362434387,
-0.3051243722438812,
0.07056768983602524,
0.013760611414909363,
0.035336609929800034,
0.062466781586408615,
0.0709225982427597,
-0.12565764784812927,
0.1232154592871666,
-0.056159015744924545,
0.054030418395996094,
-0.02484576404094696,
0.15549635887145996,
0.03470360115170479,
-0.2173347771167755,
0.052262887358665466,
-0.041791874915361404,
0.15363094210624695,
0.07723864167928696,
0.09824389219284058,
0.08849049359560013,
-0.23384341597557068,
-0.20877771079540253,
-0.05612296238541603,
0.15180054306983948,
0.33754900097846985,
-0.22678489983081818,
-0.014567735604941845,
0.32171615958213806,
0.04943354055285454,
0.10522010177373886,
0.10105857998132706,
-0.06973209232091904,
-0.18605808913707733,
-0.2735634446144104,
0.01018974743783474,
0.034585174173116684,
-0.05907042697072029,
0.20065371692180634,
-0.18367886543273926,
-0.11162474751472473,
0.06876402348279953,
0.15515509247779846,
-0.06857527792453766,
-0.08318836241960526,
0.14783844351768494,
-0.0685407742857933,
0.2472592145204544,
0.11284297704696655,
0.3081078827381134,
-0.1771087348461151,
-0.08614175021648407,
-0.04479765146970749,
0.05034533888101578,
-0.26166582107543945,
-0.2615757882595062,
0.04609265178442001,
0.06308068335056305,
-0.23633621633052826,
-0.051793016493320465,
0.011289111338555813,
-0.21293024718761444,
-0.2792976200580597,
-0.03400080278515816,
-0.11006243526935577,
-0.005587379448115826,
-0.23141369223594666,
0.04557063430547714,
-0.10007625818252563,
0.013688966631889343,
0.12556296586990356,
-0.0022296784445643425,
0.058910612016916275,
0.0009837134275585413,
-0.0682830959558487,
0.03897852450609207,
0.07022450119256973,
-0.21839354932308197,
-0.1359727531671524,
0.1353423148393631,
0.17749392986297607,
0.025296831503510475,
-0.08543702214956284,
0.052591290324926376,
-0.10201235115528107,
0.06086253002285957,
-0.10826991498470306,
-0.038644444197416306,
-0.08314770460128784,
-0.16677367687225342,
0.18064770102500916,
0.04120488092303276,
-0.33886638283729553,
-0.06634330004453659,
0.11331667751073837,
-0.08235540986061096,
0.12670114636421204,
-0.10745330899953842,
0.23153434693813324,
0.020771244540810585,
0.08917365968227386,
0.0014280416071414948,
-0.08611897379159927,
-0.13963283598423004,
-0.1682053655385971,
0.2651478052139282,
-0.028890127316117287,
-0.38575950264930725,
-0.042543139308691025,
0.24862100183963776,
0.18967123329639435,
-0.11027807742357254,
-0.25516727566719055,
0.20139926671981812,
0.02669655904173851,
0.19018128514289856,
-0.05317775160074234,
-0.07223381847143173,
0.1573280692100525,
0.040946394205093384,
0.11468635499477386,
-0.2016313523054123,
0.23795028030872345,
-0.3281727433204651,
-0.208165243268013,
0.08046804368495941,
-0.013251995667815208,
0.06449205428361893,
-0.0745435431599617,
0.17265702784061432,
-0.12398086488246918,
0.12406808882951736,
0.6233692169189453,
0.06098438799381256,
-0.13725312054157257,
-0.10043581575155258,
-0.12292790412902832,
-0.14924201369285583,
0.2290477305650711,
0.07274062186479568,
-0.0033103355672210455,
0.09870488196611404,
-0.11517639458179474,
-0.2691293954849243,
0.25537028908729553,
-0.09887256473302841,
0.06742393225431442,
0.16650958359241486,
-0.23589769005775452,
-0.026727566495537758,
-0.04839864745736122,
0.027775386348366737,
-0.3335878551006317,
-0.07486114650964737,
-0.11908944696187973,
0.17801667749881744,
-0.1508316695690155,
0.12756939232349396,
0.16090069711208344,
-0.0677061453461647,
-0.14830215275287628,
0.1290961056947708,
0.16453953087329865,
0.05366143584251404,
-0.031025782227516174,
0.1383427381515503,
-0.09342344850301743,
-0.06746886670589447,
0.1366262584924698,
-0.10588597506284714,
-0.11238772422075272,
-0.10626795142889023,
0.013653294183313847,
0.03915565088391304,
0.002781553892418742,
0.05781804770231247,
-0.12329069525003433,
-0.060449257493019104,
-0.08749260008335114,
-0.3843899071216583,
0.11205524951219559,
-0.01857137121260166,
0.00960434041917324,
-0.09141871333122253,
0.1407146453857422,
0.18570071458816528,
0.23078535497188568,
-0.37776321172714233,
0.01609988324344158,
-0.02587815746665001,
0.025528429076075554,
0.2057458460330963,
0.031449392437934875,
-0.21082253754138947,
-0.1960868537425995,
0.09110531955957413,
0.0676538422703743,
-0.1943053901195526,
-0.10248751938343048,
0.16689017415046692,
0.02382580004632473,
-0.03253701329231262,
0.032263271510601044,
0.08193004131317139,
0.038217902183532715,
0.2028871774673462,
0.10681971162557602,
-0.16013203561306,
0.06935172528028488,
-0.20972587168216705,
0.17716564238071442,
-0.04486137628555298,
-0.06857501715421677,
-0.09346503019332886,
-0.44981592893600464,
-0.015945376828312874,
-0.12867434322834015,
-0.0034194837789982557,
0.08509378880262375,
0.0439985953271389,
0.12484170496463776,
-0.04720580577850342,
0.12413256615400314,
0.15293391048908234,
-0.3894067704677582,
0.35371658205986023,
-0.03542662784457207,
-0.08114506304264069,
0.4203382730484009,
0.19858381152153015,
-0.12438427656888962,
-0.012439204379916191,
-0.15014494955539703,
-0.03248199447989464,
0.09910192340612411,
-0.04739920422434807,
-0.10186972469091415,
-0.05768101289868355,
-0.05898568034172058,
0.1334027647972107,
0.183069109916687,
0.16147801280021667,
0.18717505037784576,
0.00246100639924407,
-0.00016809761291369796,
0.03871540725231171,
-0.1991281658411026,
0.1252276450395584,
-0.1145404800772667,
-0.1312396377325058,
0.10026367008686066,
-0.025175435468554497,
0.16011729836463928,
-0.21347223222255707,
0.1021413654088974,
0.12557688355445862,
0.2051793783903122,
-0.04178755730390549,
-0.13061244785785675,
-0.018344078212976456,
0.2220696210861206,
-0.08618525415658951,
-0.05641935020685196,
-0.06087544187903404,
0.07829294353723526,
-0.12982359528541565,
-0.061067380011081696,
-0.037074584513902664,
0.13111792504787445,
-0.07756567001342773,
-0.23307065665721893,
-0.16196435689926147,
0.22950667142868042,
-0.10003133863210678,
-0.0067713018506765366,
0.10957396030426025,
0.30352258682250977,
0.051552847027778625,
0.4065243601799011,
-0.16568225622177124,
-0.078312449157238,
0.10619930177927017,
0.018196623772382736,
0.24286887049674988,
-0.17916156351566315,
0.11532928794622421,
-0.10032796859741211,
0.051995955407619476,
0.20311066508293152,
0.019732622429728508,
0.37286412715911865,
0.2700944244861603,
-0.3276243507862091,
0.029663899913430214,
0.07494804263114929,
-0.20693081617355347,
-0.22612716257572174,
0.08099203556776047,
-0.03301325812935829,
0.16431957483291626,
-0.10339146852493286,
-0.18780340254306793,
0.011020160280168056,
0.19115050137043,
-0.3736801743507385,
0.16938026249408722,
0.1371360570192337,
0.10633121430873871,
0.03621473163366318,
0.10506623983383179,
-0.0021948767825961113,
0.11306548118591309,
-0.07554903626441956,
0.06745688617229462,
-0.18088558316230774,
-0.1861942559480667,
-0.22028133273124695,
0.09120147675275803,
0.11725294589996338,
0.07619170844554901,
-0.07706581056118011,
0.08809243142604828,
-0.03688874468207359,
0.13009819388389587,
0.08993344008922577,
-0.11383328586816788,
0.15997549891471863,
-0.23126725852489471,
-0.09629503637552261,
-0.2309877872467041,
0.09956501424312592,
0.4927135109901428,
0.02669443003833294,
0.15871067345142365,
0.14445722103118896,
-0.18916237354278564,
0.19504952430725098,
-0.30465930700302124,
-0.06512010097503662,
-0.1088886708021164,
0.12998069822788239,
0.19805672764778137,
0.12645283341407776,
0.106819748878479,
0.03306078165769577,
-0.2217579483985901,
0.026718519628047943,
0.21124807000160217,
-0.057633087038993835,
-0.08427693694829941,
-0.03770933300256729,
-0.3183656334877014,
0.19915838539600372,
0.0868631973862648,
0.15442585945129395,
0.3334329426288605,
0.09258919209241867,
-0.2890188992023468,
-0.16747435927391052,
-0.10926555842161179,
-0.08501880615949631,
0.2152072936296463,
-0.27814558148384094,
-0.10536769032478333,
-0.10623323172330856,
0.079025499522686,
-0.2342870533466339,
-0.0881940945982933,
-0.264830619096756,
-0.16674046218395233,
-0.18698421120643616,
-0.08041559904813766,
0.011266815476119518,
0.052910495549440384,
-0.007153917104005814,
-0.007173364516347647,
-0.25678643584251404,
0.32333841919898987,
-0.0037223990075290203,
0.1013406440615654,
-0.03284621611237526,
0.40206480026245117,
-0.05379344895482063,
0.02479398436844349,
0.2119971215724945,
-0.1940835863351822,
-0.05490986257791519,
-0.032742228358983994,
0.06562776118516922,
0.08713651448488235,
0.07716662436723709,
-0.04258814454078674,
-0.2180333286523819,
-0.10019506514072418,
0.0069603025913238525,
0.06928304582834244,
0.017578519880771637,
0.16750553250312805,
0.0065233358182013035,
-0.00904143787920475,
-0.16949880123138428,
-0.056995220482349396,
-0.011440891772508621,
0.14857704937458038,
0.1393395960330963,
0.07231175899505615,
-0.16572412848472595,
-0.26845601201057434,
-0.13607150316238403,
0.016887027770280838,
0.07950402796268463,
-0.2356533408164978,
-0.2907900810241699,
-0.16169486939907074,
-0.43271782994270325,
-0.08213654160499573,
-0.12790924310684204,
0.1184607744216919,
0.3141001760959625,
-0.024818217381834984,
0.044155288487672806,
-0.18203607201576233,
-0.22027935087680817,
-0.04625178501009941,
-0.13129810988903046,
0.24604935944080353,
0.03896334767341614,
0.09718336910009384,
-0.13003621995449066,
-0.24409639835357666,
-0.19076888263225555,
-0.09249569475650787,
0.17244671285152435,
0.22098878026008606,
0.03215210139751434,
-0.18663789331912994,
-0.029015036299824715,
0.14702744781970978,
0.1691656857728958,
0.16746938228607178,
0.0735446885228157,
-0.12768268585205078,
0.03756646066904068,
-0.1722550094127655,
0.14360611140727997,
-0.18396930396556854,
0.0685117319226265,
0.021897878497838974,
0.09795642644166946,
-0.024937300011515617,
0.029151801019906998,
-0.1503208726644516,
0.40823304653167725,
-0.3142102360725403,
0.11567046493291855,
-0.25299450755119324,
-0.08941357582807541,
-0.09090817719697952,
0.28470173478126526,
0.185561865568161,
0.12905967235565186,
-0.14745211601257324,
0.07569670677185059,
0.17674726247787476,
0.07420796900987625,
0.005801765713840723,
0.1720016449689865,
-0.07299653440713882,
-0.17235855758190155,
-0.16352908313274384,
0.12281011044979095,
0.07335752248764038,
-0.26563718914985657,
0.10801203548908234,
-0.08039306849241257,
-0.02221566252410412,
-0.055527180433273315,
-0.04536408185958862,
-0.3572457730770111,
0.18931178748607635,
-0.06860287487506866,
0.0536133274435997,
0.06319230794906616,
0.053328126668930054,
0.06111025810241699,
-0.11780297756195068,
0.15078482031822205,
0.0865800678730011,
0.0826367661356926,
0.12393810600042343,
0.029775412753224373,
-0.08478184044361115,
-0.16732507944107056,
-0.2989223301410675,
0.20571276545524597,
-0.24770496785640717,
-0.0021308003924787045,
-0.10512633621692657,
-0.02699412778019905,
0.09322062134742737,
-0.023452278226614,
0.13867880403995514,
-0.09869320690631866,
-0.17032746970653534,
0.12182608991861343,
-0.23417013883590698,
-0.14071892201900482,
-0.30874407291412354,
0.08258083462715149,
0.24664552509784698,
-0.0181219931691885,
-0.11831526458263397,
0.017131522297859192,
0.006580510176718235,
-0.1581224948167801,
0.049800992012023926,
-0.22616760432720184,
0.23702014982700348,
-0.2114136964082718,
-0.31725990772247314,
-0.12960246205329895,
0.08779814839363098,
0.007229870650917292,
0.08332880586385727,
-0.039048630744218826,
-0.009893818758428097,
0.0029136943630874157,
-0.17353373765945435,
-0.032671160995960236,
-0.203688383102417,
0.2912091314792633,
0.15177445113658905,
-0.2399868369102478,
-0.20364512503147125,
0.1093507632613182,
0.23438110947608948,
0.09041145443916321,
-0.1166016235947609,
-0.25700727105140686,
-0.0556316077709198,
-0.18469862639904022,
0.20013168454170227,
0.0899777039885521,
0.18145106732845306,
0.06906980276107788,
-0.12614452838897705,
-0.05769446864724159,
0.061899274587631226,
0.22607165575027466,
0.16997160017490387,
-0.19883017241954803,
0.3321208953857422,
0.05520525947213173,
0.030292397364974022,
-0.1454322785139084,
0.0863424614071846,
-0.12731297314167023,
0.15630477666854858,
0.3535406291484833,
0.2730333209037781,
0.15383420884609222,
-0.0711325854063034,
-0.10422950237989426,
0.07326533645391464,
0.04202288016676903,
0.0310660507529974,
0.18787436187267303,
-0.06872650235891342,
-0.2529805600643158,
-0.21532875299453735,
0.09870201349258423,
0.2514582574367523,
-0.16655868291854858,
0.03732611984014511,
0.04200608655810356,
-0.08000018447637558,
-0.07755831629037857,
-0.21985763311386108,
-0.2033529132604599,
0.19565248489379883,
0.08262929320335388,
0.2873517870903015,
0.08765837550163269,
0.30919015407562256,
0.01995518058538437,
-0.08519894629716873,
0.2830026149749756,
-0.19532033801078796,
-0.02684379182755947,
0.07367502152919769,
-0.08864881843328476,
-0.0035622494760900736,
-0.0732826516032219,
-0.3065827786922455,
-0.2133878469467163,
-0.13748279213905334,
0.18459802865982056,
0.3054698407649994,
-0.0465889610350132,
-0.046342045068740845,
0.06636593490839005,
-0.007275855168700218,
-0.3660035729408264,
-0.07217367738485336,
0.19509363174438477,
0.1865798830986023
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. % in the Jamaican Cohort Study , and in 1.7% to 13.2% of Africans.Although urinary excretion of hydroxyproline has been shown to be significantly increased in persons with sickle cell disease compared to controls (presumably due to bone involvement), glycylprolinuria has not been reported in SCD. More importantly, although individuals with prolidase deficiency can have mild findings of hemolysis, they do not have veno-occlusive episodes. SCD is caused by biallelic pathogenic variants in HBB and inherited in an autosomal recessive manner.Beta-thalassemia is characterized by reduced synthesis of the hemoglobin subunit beta (hemoglobin beta chain) that results in reduced amounts of hemoglobin A, microcytic hypochromic anemia, and an abnormal peripheral blood smear with nucleated red blood cells. Affected individuals with other hemoglobinopathies such as β-thalassemia can also have chronic leg ulcers , but again no imidopeptiduria is known to occur. Persons with prolidase deficiency should | [
-0.08995116502046585,
0.01224587019532919,
-0.061418987810611725,
-0.05066448077559471,
0.17022134363651276,
0.07743322104215622,
0.34504446387290955,
-0.12107989937067032,
-0.09430132061243057,
-0.1974654644727707,
0.2852937579154968,
0.23362745344638824,
0.2525050640106201,
0.031381722539663315,
-0.17720672488212585,
0.21065989136695862,
0.030036287382245064,
0.18776197731494904,
-0.20442694425582886,
-0.10437972098588943,
0.0018231944413855672,
-0.062250107526779175,
0.1318955272436142,
0.11604320257902145,
-0.03499028459191322,
-0.09656041115522385,
0.010363226756453514,
0.08816099911928177,
-0.28181397914886475,
0.36420050263404846,
0.2556641101837158,
-0.0965966135263443,
0.2023753523826599,
-0.1278008371591568,
0.17146722972393036,
-0.0655083879828453,
-0.2946625351905823,
-0.13908345997333527,
0.2857854962348938,
0.04306555539369583,
0.033970385789871216,
0.046497758477926254,
0.12747682631015778,
-0.03921082615852356,
-0.12148629128932953,
-0.049502305686473846,
0.011992880143225193,
-0.12490536272525787,
0.06127187982201576,
0.08687137067317963,
0.024179523810744286,
-0.11928199231624603,
-0.2202368527650833,
-0.009486027993261814,
0.08738095313310623,
0.10416486859321594,
0.03131362795829773,
0.027833005413413048,
-0.025327708572149277,
0.2861495316028595,
-0.04762011766433716,
-0.13516481220722198,
-0.02161569707095623,
-0.24563661217689514,
0.2405005693435669,
-0.2571982443332672,
-0.20381581783294678,
-0.14216621220111847,
-0.03840513899922371,
0.37986892461776733,
0.39182043075561523,
-0.09853781014680862,
0.020201176404953003,
0.06308062374591827,
-0.27268314361572266,
-0.06019144132733345,
0.10516902059316635,
-0.41558772325515747,
-0.006259160116314888,
-0.3004648685455322,
-0.08121205121278763,
0.04799048230051994,
-0.058416109532117844,
0.07416584342718124,
-0.3134710490703583,
-0.07034223526716232,
-0.06450974941253662,
-0.06868486851453781,
-0.05612144619226456,
0.40010347962379456,
0.06970610469579697,
0.08670876920223236,
0.02052529715001583,
0.11197768151760101,
-0.08821935206651688,
-0.07518043369054794,
0.19844116270542145,
-0.14920395612716675,
0.10982222855091095,
-0.008482227101922035,
-0.02815287560224533,
0.026935042813420296,
-0.03521997854113579,
0.09151483327150345,
-0.2641562223434448,
-0.2333793193101883,
-0.16292352974414825,
-0.1259843409061432,
-0.2707069516181946,
-0.028992120176553726,
0.253500372171402,
-0.162880539894104,
-0.10610785335302353,
-0.21432115137577057,
-0.17693468928337097,
0.18028554320335388,
-0.0443618968129158,
0.25282248854637146,
0.09187552332878113,
-0.07136442512273788,
0.10005690157413483,
-0.029314499348402023,
0.008692874573171139,
0.0048951865173876286,
-0.13032670319080353,
0.15706315636634827,
-0.0021693273447453976,
0.08871453255414963,
0.30130183696746826,
0.21798160672187805,
0.03953217342495918,
0.08125796914100647,
0.22671160101890564,
-0.21382823586463928,
-0.13134033977985382,
-0.04523732140660286,
-0.3031936585903168,
0.041338350623846054,
-0.16582907736301422,
0.03195924311876297,
-0.28670671582221985,
-0.05058726295828819,
0.15806972980499268,
0.4375021159648895,
-0.11157442629337311,
-0.2458096295595169,
0.4212642312049866,
0.10176853090524673,
0.15352822840213776,
-0.149819478392601,
0.28847190737724304,
-0.23156793415546417,
0.3767462372779846,
-0.08927085250616074,
-0.32144227623939514,
0.26846128702163696,
-0.0387335829436779,
-0.0063154809176921844,
-0.1151275709271431,
-0.3185761570930481,
0.3005940616130829,
-0.08048131316900253,
-0.035770684480667114,
-0.000551799254026264,
0.04023260250687599,
-0.029243122786283493,
0.016961468383669853,
-0.06151812523603439,
0.2289571613073349,
0.27960100769996643,
-0.16614174842834473,
-0.04341282695531845,
0.041077326983213425,
-0.005950083024799824,
0.3695427477359772,
0.11400827020406723,
-0.0397220104932785,
-0.04513855651021004,
-0.24807456135749817,
-0.09010762721300125,
-0.09185155481100082,
0.11579880118370056,
0.020478591322898865,
-0.20448677241802216,
0.11083496361970901,
-0.10125971585512161,
0.20785877108573914,
0.13345713913440704,
-0.2700899541378021,
0.06894943863153458,
0.2715480625629425,
0.10989230871200562,
0.10787590593099594,
0.041289038956165314,
-0.16583414375782013,
-0.06863830238580704,
-0.1711951196193695,
0.0162894818931818,
0.2021772563457489,
-0.36089345812797546,
0.3461623787879944,
-0.15898151695728302,
-0.0665540099143982,
0.1192842647433281,
-0.04941800981760025,
-0.06541545689105988,
0.13881678879261017,
0.16992606222629547,
-0.1669054478406906,
0.3415435552597046,
0.1661572903394699,
0.16829365491867065,
-0.11474446207284927,
-0.12880860269069672,
-0.059615008533000946,
-0.13764066994190216,
-0.15492701530456543,
-0.09106769412755966,
0.10003380477428436,
0.1200493797659874,
0.19240981340408325,
0.12577424943447113,
0.20187221467494965,
-0.30425503849983215,
-0.21951498091220856,
-0.05163087695837021,
0.05926856771111488,
0.0750640481710434,
-0.27498942613601685,
-0.047912441194057465,
-0.10498428344726562,
0.038088515400886536,
0.09589112550020218,
-0.10071320831775665,
-0.04669097065925598,
-0.11254964023828506,
-0.13926561176776886,
0.18717870116233826,
0.09471311420202255,
0.05784548074007034,
-0.2579520344734192,
0.1631290167570114,
0.078841932117939,
-0.07348807156085968,
0.043504662811756134,
0.24146144092082977,
-0.2677125632762909,
0.14607350528240204,
-0.5133954882621765,
-0.01606880873441696,
-0.08119337260723114,
0.05594756826758385,
-0.1314685046672821,
0.01782851479947567,
-0.2737223505973816,
-0.152465358376503,
0.21476392447948456,
-0.021581968292593956,
-0.006714911665767431,
0.14011983573436737,
0.1606932282447815,
0.003348124213516712,
-0.1558981090784073,
-0.21661490201950073,
-0.019925525411963463,
-0.2844773828983307,
-0.23403266072273254,
-0.005192595534026623,
0.05645546689629555,
-0.36778807640075684,
0.005836097057908773,
0.10843873769044876,
0.1547279953956604,
-0.011086998507380486,
-0.06707866489887238,
0.1664511114358902,
-0.06506748497486115,
0.182956725358963,
0.13083185255527496,
0.14987313747406006,
-0.2738313674926758,
0.06504655629396439,
0.07425730675458908,
0.1643848419189453,
0.213775172829628,
-0.29476624727249146,
-0.1622626781463623,
-0.12742109596729279,
0.005101874470710754,
-0.11653504520654678,
-0.1880752593278885,
0.2710898220539093,
-0.1607218086719513,
0.1429229974746704,
0.3260163366794586,
0.00010862736962735653,
-0.14510737359523773,
-0.11663039028644562,
-0.012465293519198895,
-0.12482830882072449,
0.16135285794734955,
0.18201002478599548,
-0.0007363984477706254,
0.13547228276729584,
-0.13679276406764984,
-0.17685741186141968,
0.220842182636261,
0.0013070165878161788,
-0.05797922983765602,
0.20938640832901,
-0.1665918231010437,
-0.19319941103458405,
-0.022793635725975037,
0.13344669342041016,
-0.25413089990615845,
-0.1276901215314865,
0.03656577691435814,
0.050181083381175995,
0.2410711944103241,
0.13949541747570038,
0.17615506052970886,
-0.06833890825510025,
-0.06650730222463608,
0.2913263440132141,
-0.12078394740819931,
0.2733703553676605,
-0.07540634274482727,
0.02000105194747448,
0.0027875250671058893,
-0.21432434022426605,
0.11262968182563782,
0.13760460913181305,
-0.05189749598503113,
0.03593800961971283,
0.15038542449474335,
-0.0383843295276165,
0.16233742237091064,
0.056852929294109344,
-0.03855311498045921,
-0.1283041089773178,
0.04435640573501587,
-0.26066526770591736,
0.1250613033771515,
-0.2615588903427124,
0.2740279734134674,
-0.04974391311407089,
0.044596314430236816,
0.15126630663871765,
0.309663325548172,
-0.11878985911607742,
-0.1898980736732483,
0.19217464327812195,
0.08831937611103058,
0.22474832832813263,
0.22548280656337738,
-0.37373119592666626,
-0.0823206752538681,
0.04141297563910484,
0.20581971108913422,
-0.0866725817322731,
-0.3054766058921814,
0.11425352096557617,
-0.013296667486429214,
-0.20314696431159973,
0.09088563919067383,
0.21439450979232788,
-0.052787646651268005,
0.3863527774810791,
0.04692911356687546,
0.10737776756286621,
0.43736976385116577,
-0.04234065115451813,
0.2553102374076843,
0.10792703181505203,
-0.03189770132303238,
-0.09530509263277054,
-0.16909314692020416,
0.28120145201683044,
-0.11064494401216507,
0.06924387812614441,
0.015605723485350609,
0.20628851652145386,
0.23980902135372162,
0.01150419469922781,
0.3041151463985443,
0.21874913573265076,
-0.10377761721611023,
0.15496645867824554,
0.1366218626499176,
-0.34494397044181824,
0.3130843937397003,
0.10178617388010025,
-0.07508094608783722,
0.03490876033902168,
-0.1602969914674759,
0.2415148764848709,
0.09009121358394623,
0.2160927951335907,
-0.10779756307601929,
-0.11619590222835541,
0.04545499384403229,
-0.023409651592373848,
0.14995239675045013,
0.07617881149053574,
0.10032830387353897,
0.03214292973279953,
-0.04216371476650238,
0.2214408963918686,
-0.24193276464939117,
0.17502178251743317,
0.139583557844162,
0.014984332025051117,
-0.014064228162169456,
-0.07332193851470947,
-0.008260013535618782,
-0.1613234579563141,
0.07753822207450867,
-0.09843460470438004,
0.387178510427475,
-0.023433832451701164,
-0.4315619170665741,
-0.05466224625706673,
0.1646692156791687,
0.044443294405937195,
0.0009644909296184778,
-0.09841389209032059,
0.12944769859313965,
0.19171863794326782,
0.33959609270095825,
0.002257336163893342,
0.12838643789291382,
-0.034152645617723465,
-0.08908996731042862,
-0.22916923463344574,
0.3569791913032532,
0.13547098636627197,
-0.10124083608388901,
0.08727921545505524,
0.16078311204910278,
-0.2488337755203247,
0.26586416363716125,
0.34692540764808655,
-0.16660833358764648,
-0.06299933791160583,
-0.10259925574064255,
0.22531388700008392,
-0.13832205533981323,
0.17950138449668884,
-0.29314088821411133,
0.15475335717201233,
0.1460084766149521,
-0.1915837675333023,
0.10333942621946335,
0.267221599817276,
-0.031120043247938156,
-0.07598058879375458,
0.06360739469528198,
0.003937163390219212,
-0.37796056270599365,
-0.1561041921377182,
0.05428958684206009,
0.162599116563797,
0.30608078837394714,
-0.14554722607135773,
0.35240691900253296,
-0.028710298240184784,
-0.3466266691684723,
0.04730330780148506,
0.14521504938602448,
0.14030279219150543,
0.05387420207262039,
0.08339609950780869,
0.15113011002540588,
-0.01934306137263775,
-0.03898455575108528,
0.059085290879011154,
0.027718590572476387,
-0.31464388966560364,
0.01817120611667633,
0.4555215835571289,
0.18222589790821075,
-0.0567806251347065,
-0.1704229712486267,
0.17437036335468292,
-0.07864858210086823,
0.22784988582134247,
0.019633693620562553,
-0.26783984899520874,
0.28310778737068176,
-0.1284593939781189,
0.47414690256118774,
0.05732209235429764,
0.28039655089378357,
0.29588374495506287,
-0.10545911639928818,
-0.2738092839717865,
-0.04421817138791084,
-0.2293165624141693,
-0.014397410675883293,
-0.23546133935451508,
0.00965938251465559,
0.034391190856695175,
0.017340708523988724,
0.1463186889886856,
-0.22079525887966156,
0.29163631796836853,
-0.2495318204164505,
-0.0994848757982254,
0.012929211370646954,
0.10135478526353836,
0.16305217146873474,
-0.13472804427146912,
0.011613966897130013,
-0.2255467176437378,
0.13959725201129913,
-0.34485578536987305,
0.3225516676902771,
0.21882463991641998,
0.07368873804807663,
-0.259506493806839,
-0.02284335158765316,
-0.12440299242734909,
0.1410638391971588,
0.08590535819530487,
-0.20247894525527954,
0.13126102089881897,
-0.0926966592669487,
0.13579681515693665,
-0.3277639150619507,
-0.053292449563741684,
-0.28274261951446533,
-0.10788943618535995,
-0.30591705441474915,
0.24557264149188995,
0.14815473556518555,
-0.1617651879787445,
0.08195867389440536,
-0.023089667782187462,
0.00812182854861021,
0.2268175184726715,
-0.14741522073745728,
-0.014676366932690144,
-0.12468267232179642,
0.1277792602777481,
-0.2756825387477875,
-0.1100602000951767,
0.04104341194033623,
-0.16864125430583954,
-0.05074906721711159,
-0.11927559226751328,
-0.14589591324329376,
-0.1214076578617096,
0.11389537155628204,
0.2509886920452118,
-0.01876768469810486,
0.08702695369720459,
0.08993057906627655,
-0.23127073049545288,
0.03646519407629967,
0.11883377283811569,
0.11785434186458588,
-0.2475324273109436,
-0.2526591420173645,
-0.07997548580169678,
0.09189072251319885,
0.17900203168392181,
0.003259170101955533,
0.0464329794049263,
0.22445499897003174,
-0.3481629192829132,
-0.06708122789859772,
0.19771146774291992,
0.1339522749185562,
-0.10545200109481812,
-0.2490265816450119,
-0.13718894124031067,
-0.2295769304037094,
0.10281231999397278,
-0.14210385084152222,
0.21502424776554108,
-0.0012788111343979836,
0.20315006375312805,
-0.019365496933460236,
-0.03703341633081436,
-0.11915640532970428,
0.172373428940773,
0.0704333707690239,
0.051262952387332916,
0.0504327118396759,
0.00654738862067461,
-0.12720555067062378,
-0.05391816794872284,
-0.04051591455936432,
0.19410303235054016,
0.17763462662696838,
0.20526595413684845,
0.11875036358833313,
-0.08877673745155334,
-0.08889840543270111,
0.07906091958284378,
0.3034852147102356,
0.16393457353115082,
0.11534328013658524,
-0.06690291315317154,
0.14450573921203613,
-0.20158709585666656,
0.23661111295223236,
-0.24172036349773407,
0.1822117269039154,
0.0682772621512413,
-0.09323812276124954,
-0.1515139490365982,
0.1799333542585373,
0.14283546805381775,
0.17181825637817383,
-0.1406378298997879,
0.07793014496564865,
-0.22607779502868652,
-0.0705714300274849,
-0.04077993705868721,
0.4101065993309021,
-0.02059115283191204,
0.008916197344660759,
0.09332254528999329,
-0.3276709318161011,
0.20097696781158447,
-0.07688044011592865,
-0.027008643373847008,
-0.02968467026948929,
-0.1723964810371399,
-0.38460832834243774,
-0.13427403569221497,
-0.2495948076248169,
0.12346550077199936,
-0.3420774042606354,
0.05435629561543465,
0.07606952637434006,
-0.09746142476797104,
-0.1745261549949646,
-0.27380579710006714,
-0.018461525440216064,
0.15607509016990662,
0.06933382153511047,
0.3049684464931488,
0.15527716279029846,
0.09650028496980667,
-0.036635804921388626,
-0.12393584102392197,
0.04810743033885956,
-0.05003735423088074,
0.23507067561149597,
0.06281112134456635,
-0.07412164658308029,
0.23894336819648743,
-0.04811473563313484,
-0.2620152533054352,
0.1117565929889679,
-0.2591607868671417,
0.2667976915836334,
-0.2998800575733185,
-0.017490075901150703,
0.2646549940109253,
-0.11043067276477814,
0.06118651106953621,
-0.09528109431266785,
-0.09694641828536987,
0.24446628987789154,
-0.017604604363441467,
-0.04564763233065605,
-0.3097057342529297,
-0.030625274404883385,
-0.026041477918624878,
-0.1572592407464981,
0.18934959173202515,
-0.14220796525478363,
-0.022104617208242416,
-0.3102649748325348,
0.040977343916893005,
-0.25730836391448975,
0.14959919452667236,
0.01079321838915348,
-0.4215148091316223,
-0.19565759599208832,
-0.005999038461595774,
-0.07185573875904083,
0.15463975071907043,
-0.09064509719610214,
0.17404648661613464,
-0.0854179710149765,
-0.001404580776579678,
0.08032097667455673,
-0.5400575995445251,
0.4449591636657715,
0.27490368485450745,
-0.15314148366451263,
-0.24873796105384827,
0.13269846141338348,
0.008802242577075958,
-0.17658811807632446,
0.08925469219684601,
-0.2713412046432495,
-0.13686734437942505,
-0.24589096009731293,
-0.016942588612437248,
-0.10175751149654388,
-0.06407245993614197,
0.09294427931308746,
-0.16718511283397675,
0.07307583093643188,
-0.022589318454265594,
-0.14392466843128204,
0.15546199679374695,
-0.26060569286346436,
0.4350799322128296,
-0.0062461490742862225,
0.015917731449007988,
-0.3151852488517761,
0.2373318374156952,
-0.21028833091259003,
0.035110872238874435,
-0.012509392574429512,
0.257894366979599,
0.1070191040635109,
-0.3230215311050415,
-0.030739756301045418,
-0.08531348407268524,
0.11152606457471848,
-0.16339558362960815,
0.30691489577293396,
-0.18758073449134827,
-0.2758113741874695,
-0.313882052898407,
0.0913010761141777,
0.05387793481349945,
-0.340767502784729,
0.09537458419799805,
-0.0688467025756836,
-0.07179883867502213,
-0.011397047899663448,
0.059251077473163605,
-0.3186415433883667,
0.1665167659521103,
-0.14102207124233246,
0.15648113191127777,
-0.08945222198963165,
0.24735771119594574,
-0.06416064500808716,
-0.037392377853393555,
0.15975524485111237,
-0.2198256105184555,
-0.1138419359922409,
0.13178972899913788,
-0.015840118750929832,
-0.02136397175490856,
-0.15855684876441956,
-0.01323355920612812,
-0.19022271037101746,
-0.4063490629196167,
0.03620859980583191,
-0.0003341732663102448,
-0.03330554440617561,
-0.2441171109676361,
0.02909654751420021,
0.002006972674280405,
-0.1107848510146141,
-0.2610679566860199,
0.08883188664913177,
0.11941544711589813
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. by biallelic pathogenic variants in HBB and inherited in an autosomal recessive manner.Beta-thalassemia is characterized by reduced synthesis of the hemoglobin subunit beta (hemoglobin beta chain) that results in reduced amounts of hemoglobin A, microcytic hypochromic anemia, and an abnormal peripheral blood smear with nucleated red blood cells. Affected individuals with other hemoglobinopathies such as β-thalassemia can also have chronic leg ulcers , but again no imidopeptiduria is known to occur. Persons with prolidase deficiency should have a normal hemoglobin electrophoretic pattern. β-thalassemia is caused by biallelic pathogenic variants in HBB and inherited in an autosomal recessive manner.Acquired causes of lower-extremity ulcers include arterial insufficiency, venous insufficiency, pressure ulcers, vasculitis, systemic lupus erythematosus, and infectious etiologies, among others. Although glycineprolinuria could be anticipated in cases of secondary skin ulcers given the high content of collagen in the dermis, a number of patients with extensive skin ulceration have been tested | [
-0.10195135325193405,
0.16111665964126587,
0.01814674399793148,
-0.05037180706858635,
0.20752346515655518,
0.13624943792819977,
0.12418078631162643,
-0.14203433692455292,
-0.2116234451532364,
-0.21447913348674774,
0.3278059959411621,
0.09854067116975784,
0.2098015546798706,
0.023559805005788803,
-0.211961567401886,
0.3550991714000702,
-0.048556797206401825,
0.18176208436489105,
-0.1432829648256302,
-0.20910155773162842,
-0.063611701130867,
-0.02583901956677437,
0.05886109545826912,
0.14434941112995148,
0.07944242656230927,
-0.060209695249795914,
-0.045981813222169876,
0.13120415806770325,
-0.33150747418403625,
0.32681187987327576,
-0.03086886927485466,
-0.07674093544483185,
0.17525345087051392,
-0.2113938331604004,
0.09821520745754242,
-0.08211468160152435,
-0.2132125198841095,
-0.2583116590976715,
0.3512285053730011,
0.09188573807477951,
-0.04646192491054535,
0.06072504445910454,
0.07061009109020233,
0.038345012813806534,
-0.167422354221344,
-0.05266984924674034,
0.04496227949857712,
-0.009402547031641006,
-0.08572075515985489,
0.08962231129407883,
0.17302155494689941,
-0.14566154778003693,
-0.062114082276821136,
0.0022731481585651636,
0.13791035115718842,
0.09056416153907776,
0.0776941105723381,
0.2039598822593689,
0.02323894016444683,
0.17310486733913422,
0.07218702882528305,
-0.1294056475162506,
-0.01729622855782509,
-0.41803160309791565,
0.3788202404975891,
-0.35739535093307495,
-0.18817682564258575,
-0.1929267793893814,
-0.016994120553135872,
0.33027559518814087,
0.4133250415325165,
0.0006702296668663621,
0.02244238741695881,
0.16371005773544312,
-0.22989606857299805,
-0.16198579967021942,
0.16132616996765137,
-0.23427461087703705,
-0.07251816987991333,
-0.3051222562789917,
-0.2109234631061554,
0.07012002915143967,
-0.00276319426484406,
0.09835514426231384,
-0.20558594167232513,
0.11016958951950073,
0.07961305975914001,
0.0822514146566391,
-0.160301074385643,
0.26177123188972473,
0.11292736977338791,
-0.07180503755807877,
-0.00917214434593916,
0.04534244164824486,
-0.011659061536192894,
-0.15733858942985535,
0.2527557611465454,
-0.24986502528190613,
0.03219609335064888,
-0.024804269894957542,
-0.004879684653133154,
-0.01760954223573208,
0.023980194702744484,
-0.09271203726530075,
-0.18921694159507751,
-0.14766770601272583,
-0.31589213013648987,
-0.050409168004989624,
-0.16641756892204285,
0.0037983101792633533,
0.15133444964885712,
-0.1999075710773468,
-0.06619971245527267,
-0.2728404998779297,
-0.16535280644893646,
0.258124440908432,
0.022888196632266045,
0.19074374437332153,
0.08155669271945953,
-0.1680103987455368,
0.001227573724463582,
-0.07581111788749695,
0.02735607698559761,
-0.08451353758573532,
0.003969163633882999,
0.19626684486865997,
0.10130070149898529,
0.012545091100037098,
0.24029673635959625,
0.15851855278015137,
-0.0034600836224853992,
-0.10125903785228729,
0.09881676733493805,
-0.409221351146698,
-0.23649203777313232,
0.1143396869301796,
-0.18959535658359528,
-0.07996287196874619,
-0.30924737453460693,
-0.04199681058526039,
-0.2390114814043045,
-0.09519699960947037,
0.17641212046146393,
0.4419070780277252,
-0.17601549625396729,
-0.10861364752054214,
0.5336054563522339,
0.13391649723052979,
0.10680839419364929,
-0.267262727022171,
0.260355681180954,
-0.18286050856113434,
0.4583779275417328,
0.052364494651556015,
-0.2350156456232071,
0.22714771330356598,
-0.19544048607349396,
0.0016685391310602427,
-0.18093180656433105,
-0.43850430846214294,
0.31840500235557556,
-0.096950463950634,
0.0736086443066597,
0.06329021602869034,
-0.023411521688103676,
0.058459389954805374,
-0.08180341869592667,
-0.13340908288955688,
0.24876169860363007,
0.2616187334060669,
-0.040973834693431854,
-0.12455493211746216,
0.08713850378990173,
0.08302538096904755,
0.376590758562088,
-0.1248539611697197,
-0.09518773853778839,
-0.12313611805438995,
-0.2197607010602951,
0.008012578822672367,
-0.03793438896536827,
0.10315835475921631,
-0.06939563900232315,
-0.20956747233867645,
0.039397723972797394,
-0.11822829395532608,
0.1082310602068901,
0.22198669612407684,
-0.09244561940431595,
0.0251288041472435,
0.19579783082008362,
0.20440733432769775,
-0.035694416612386703,
-0.02006307803094387,
-0.07680586725473404,
-0.20247232913970947,
-0.14552786946296692,
-0.043219082057476044,
0.06260620057582855,
-0.2465144693851471,
0.3933078944683075,
-0.18167321383953094,
0.12351787090301514,
0.14196144044399261,
0.05666668713092804,
-0.08959157019853592,
0.09707121551036835,
0.3032644987106323,
-0.12424441426992416,
0.2611596882343292,
0.2798497676849365,
0.19367867708206177,
-0.09570957720279694,
0.03301449492573738,
-0.14217253029346466,
-0.11134788393974304,
-0.17209839820861816,
-0.13739286363124847,
0.038056790828704834,
0.04456288740038872,
0.017111865803599358,
0.047668784856796265,
0.08905085176229477,
-0.4013659954071045,
-0.11944261938333511,
0.047268372029066086,
-0.011609957553446293,
0.1325145810842514,
-0.24590297043323517,
-0.047017935663461685,
-0.08391013741493225,
0.17568552494049072,
0.15893831849098206,
-0.023247193545103073,
-0.05992809310555458,
-0.17069275677204132,
-0.056637559086084366,
0.29529792070388794,
-0.007101595401763916,
0.027535993605852127,
-0.19209374487400055,
0.20360572636127472,
0.07679381966590881,
-0.10048875957727432,
0.023956364020705223,
0.21584700047969818,
-0.29088523983955383,
0.1612146496772766,
-0.43868395686149597,
-0.09187952429056168,
-0.04270672798156738,
-0.07545579969882965,
0.07695841044187546,
-0.0999729111790657,
-0.34612876176834106,
-0.08994419127702713,
0.2694340944290161,
0.010469643399119377,
0.16487160325050354,
0.08848065882921219,
0.17430107295513153,
-0.10018712282180786,
-0.058407627046108246,
-0.09121429175138474,
0.14582322537899017,
-0.10769663006067276,
-0.1126650720834732,
0.06247980520129204,
-0.01876794546842575,
-0.567327618598938,
-0.02166750095784664,
-0.012696309015154839,
0.19263677299022675,
-0.036623742431402206,
-0.003547720378264785,
0.11065930128097534,
-0.3307124674320221,
0.16820965707302094,
0.02385200932621956,
-0.006255313754081726,
-0.15790978074073792,
0.03718043118715286,
-0.006527953315526247,
0.01512168999761343,
0.2701173424720764,
-0.19060973823070526,
-0.2398567497730255,
-0.04772934317588806,
-0.07736346125602722,
-0.11027920246124268,
0.05424114316701889,
0.17967739701271057,
-0.2177685648202896,
-0.036752767860889435,
0.2891799807548523,
-0.04817541688680649,
-0.28099358081817627,
-0.06861671805381775,
0.04532795771956444,
-0.04765966534614563,
0.20663848519325256,
0.09689963608980179,
-0.1196175068616867,
0.1422135829925537,
-0.11156746000051498,
-0.0775165855884552,
0.13575221598148346,
-0.03277517855167389,
-0.043265316635370255,
0.16223910450935364,
-0.059717483818531036,
-0.18344441056251526,
-0.01962285302579403,
-0.07772950083017349,
-0.36428046226501465,
-0.17467491328716278,
-0.012229240499436855,
0.02955775335431099,
0.19199195504188538,
0.06934764981269836,
0.2043810337781906,
-0.08880696445703506,
0.025787968188524246,
0.28523045778274536,
0.08294525742530823,
0.23052768409252167,
-0.013470623642206192,
-0.14402033388614655,
-0.030176503583788872,
-0.1923791766166687,
0.09789102524518967,
-0.04340106621384621,
-0.13319246470928192,
0.1571187973022461,
0.13157175481319427,
0.0066140699200332165,
0.21476218104362488,
-0.12463515996932983,
-0.10789833217859268,
-0.3300555944442749,
0.16276702284812927,
-0.23374336957931519,
0.1909959763288498,
-0.34136804938316345,
0.05724446102976799,
0.07546314597129822,
0.04752059280872345,
0.26816344261169434,
0.14470820128917694,
-0.16200093924999237,
-0.21221700310707092,
0.02332945726811886,
-0.002546651754528284,
0.1631511151790619,
0.2748631536960602,
-0.27556312084198,
-0.17643016576766968,
0.0371442474424839,
0.21163037419319153,
-0.29984456300735474,
-0.23033425211906433,
0.19022290408611298,
0.2569024860858917,
-0.29573264718055725,
0.11852045357227325,
0.3796784281730652,
-0.07010513544082642,
0.2592734098434448,
-0.14526516199111938,
-0.004577962681651115,
0.1459953486919403,
-0.16845226287841797,
0.23078544437885284,
0.2751491665840149,
0.010376889258623123,
-0.08949905633926392,
-0.21446414291858673,
0.2615695297718048,
-0.015120597556233406,
0.06848345696926117,
-0.015868501737713814,
0.3596688508987427,
0.17392055690288544,
0.08086154609918594,
0.20622819662094116,
0.31967633962631226,
-0.15736471116542816,
0.3072649836540222,
-0.020306430757045746,
-0.28181859850883484,
0.3203745186328888,
0.17427247762680054,
-0.19736149907112122,
0.06927783042192459,
-0.2690230906009674,
0.1820051372051239,
0.05743205174803734,
0.07400518655776978,
-0.20416980981826782,
-0.026504088193178177,
0.003177558071911335,
-0.04550478234887123,
0.15844093263149261,
0.15671424567699432,
0.26770302653312683,
0.17854878306388855,
0.057153698056936264,
0.18748992681503296,
-0.11531057208776474,
0.09764133393764496,
0.1605852097272873,
-0.09160143882036209,
0.010335671715438366,
-0.10930511355400085,
0.02995387092232704,
-0.15258575975894928,
-0.032010406255722046,
0.017700685188174248,
0.4077087342739105,
0.01960812322795391,
-0.4078708291053772,
-0.08743833750486374,
0.2604151666164398,
-0.019714990630745888,
-0.19416208565235138,
0.09595713019371033,
0.15260495245456696,
0.024591658264398575,
0.2287270724773407,
-0.08126530796289444,
0.2832362949848175,
-0.07558812946081161,
0.030043825507164,
-0.19503290951251984,
0.4070168733596802,
0.11234985291957855,
-0.15581171214580536,
0.07104126363992691,
0.32577213644981384,
-0.09602826833724976,
0.27371945977211,
0.1492769569158554,
-0.25004643201828003,
-0.17445918917655945,
-0.24641504883766174,
0.23825733363628387,
-0.2815341651439667,
0.2140112966299057,
-0.0956328883767128,
0.12049199640750885,
0.14755460619926453,
-0.04389674961566925,
0.31494051218032837,
0.11270241439342499,
-0.1565409153699875,
-0.18327225744724274,
-0.10816700756549835,
-0.04329315572977066,
-0.3310595452785492,
-0.029698990285396576,
-0.034244637936353683,
-0.020306462422013283,
0.1409277766942978,
-0.3786064088344574,
0.22560818493366241,
0.07941664010286331,
-0.38662591576576233,
-0.00433393893763423,
0.19456200301647186,
-0.05781840160489082,
0.10337905585765839,
0.11449417471885681,
0.24785499274730682,
-0.05804399400949478,
-0.17280074954032898,
0.13946548104286194,
0.026224493980407715,
-0.1677454710006714,
-0.1582929641008377,
0.42121902108192444,
0.1768786460161209,
0.22024312615394592,
-0.19958780705928802,
0.13084262609481812,
-0.040613386780023575,
0.22480124235153198,
0.05158064514398575,
-0.3032515347003937,
0.3592752516269684,
-0.20245470106601715,
0.3366314470767975,
0.10298626124858856,
0.13321705162525177,
0.3914062976837158,
-0.07042263448238373,
-0.31355971097946167,
-0.0629042536020279,
-0.22841042280197144,
0.05112346261739731,
-0.22627288103103638,
0.0790068507194519,
-0.08056838810443878,
-0.07270794361829758,
0.14304719865322113,
-0.0725724846124649,
0.14672300219535828,
-0.15660037100315094,
-0.17028525471687317,
0.17743080854415894,
0.07145380973815918,
0.36945557594299316,
-0.18536972999572754,
-0.036696869879961014,
-0.33387133479118347,
0.09041287750005722,
-0.23843669891357422,
0.3980697691440582,
0.14400796592235565,
0.17531824111938477,
-0.21021156013011932,
-0.06799248605966568,
0.056951601058244705,
0.24014979600906372,
0.24485398828983307,
-0.11772025376558304,
0.029108796268701553,
0.04755420237779617,
0.08954017609357834,
-0.43088123202323914,
-0.11041191965341568,
-0.11790943890810013,
-0.22290490567684174,
-0.2826418876647949,
0.24259236454963684,
0.028484312817454338,
-0.18201765418052673,
-0.05801618844270706,
-0.018631979823112488,
0.10312148928642273,
0.15906308591365814,
-0.08138949424028397,
0.03722301125526428,
-0.13312654197216034,
0.28094902634620667,
-0.2046029418706894,
-0.08985963463783264,
0.08490611612796783,
-0.1750563234090805,
-0.16321760416030884,
-0.1857246607542038,
-0.09203699231147766,
-0.11864949017763138,
0.06440269947052002,
0.2894204258918762,
-0.06569456309080124,
0.05403445288538933,
-0.07288268208503723,
-0.3339395821094513,
-0.013900266960263252,
0.03450794145464897,
0.08885404467582703,
-0.1878427416086197,
-0.1581355780363083,
-0.10429199784994125,
0.08193742483854294,
0.18736952543258667,
-0.13866588473320007,
0.16754178702831268,
0.14275236427783966,
-0.2806002199649811,
-0.08638418465852737,
0.17316323518753052,
0.12263311445713043,
-0.29404687881469727,
-0.3882025182247162,
-0.172823965549469,
-0.2470635622739792,
0.06489095091819763,
-0.21094490587711334,
0.24834607541561127,
-0.05731586739420891,
0.059546735137701035,
-0.01280047558248043,
-0.11835130304098129,
-0.2511817216873169,
0.11642405390739441,
0.05434514209628105,
0.11100339889526367,
0.14409248530864716,
-0.05652952194213867,
-0.07426642626523972,
-0.1290023773908615,
-0.04323447495698929,
-0.059737429022789,
0.3320881128311157,
0.198917955160141,
0.13828067481517792,
-0.19081228971481323,
0.09119079262018204,
0.14204519987106323,
0.25241875648498535,
-0.007615428883582354,
0.031755249947309494,
-0.05405903607606888,
0.11736635118722916,
-0.13920480012893677,
0.25450125336647034,
-0.17872966825962067,
0.2411397099494934,
-0.020687483251094818,
0.1071125864982605,
-0.024748140946030617,
0.2281522899866104,
0.1373467594385147,
0.1967463493347168,
-0.09701073169708252,
0.03771944344043732,
-0.2948359251022339,
-0.16337944567203522,
-0.15111008286476135,
0.2597806751728058,
0.022537004202604294,
0.04566524922847748,
-0.004073729272931814,
-0.3610721826553345,
0.28611645102500916,
-0.07578496634960175,
-0.07415811717510223,
-0.07739432901144028,
-0.07092491537332535,
-0.2323928028345108,
-0.15609507262706757,
-0.1525406390428543,
0.09213206171989441,
-0.30721983313560486,
0.20332959294319153,
0.30812203884124756,
0.07125570625066757,
-0.06675565242767334,
-0.21340635418891907,
-0.04522816836833954,
0.0078032128512859344,
-0.03573029115796089,
0.2649000883102417,
0.1225685104727745,
0.08639896661043167,
-0.050572674721479416,
-0.07418680936098099,
0.20591655373573303,
-0.10298392176628113,
0.24609124660491943,
-0.033117543905973434,
0.0036268357653170824,
0.1588854193687439,
-0.08564626425504684,
-0.12106255441904068,
0.12337885051965714,
-0.33304363489151,
0.23564991354942322,
-0.2713369131088257,
0.06951852142810822,
0.0657166838645935,
-0.11462627351284027,
0.15356431901454926,
-0.1304125338792801,
-0.10869202017784119,
0.26715710759162903,
-0.171973317861557,
-0.08401814848184586,
-0.2899056673049927,
0.03189248591661453,
-0.12166619300842285,
-0.17767949402332306,
0.199744313955307,
0.027227452024817467,
-0.05497092753648758,
-0.33018529415130615,
-0.12505699694156647,
-0.29960981011390686,
0.1912396103143692,
-0.06806682050228119,
-0.35549473762512207,
-0.24322116374969482,
-0.03255019336938858,
-0.17971500754356384,
-0.031555768102407455,
-0.07096134126186371,
0.13203467428684235,
0.04171125590801239,
-0.0024634297005832195,
-0.004067238885909319,
-0.4372791349887848,
0.4566052556037903,
0.11034014821052551,
-0.15817758440971375,
-0.3264622390270233,
0.25479191541671753,
0.14483869075775146,
-0.13919557631015778,
0.034368839114904404,
-0.12028808891773224,
-0.20478761196136475,
-0.2592962682247162,
0.030648954212665558,
0.033533331006765366,
-0.00041394223808310926,
0.018024735152721405,
-0.11781100928783417,
-0.00576832564547658,
0.04385759308934212,
-0.08502147346735,
0.06502296030521393,
-0.3463040888309479,
0.33409586548805237,
-0.03607144206762314,
0.01804676093161106,
-0.31708621978759766,
0.14978960156440735,
-0.18337437510490417,
0.2541992962360382,
-0.09128124266862869,
0.2736217975616455,
0.07576771825551987,
-0.32187509536743164,
-0.15831990540027618,
0.008003412745893002,
0.006157694850116968,
-0.1381770521402359,
0.31935086846351624,
-0.1576346755027771,
-0.3100990951061249,
-0.38573747873306274,
-0.07004950195550919,
0.24895784258842468,
-0.1567414104938507,
0.18788589537143707,
-0.04988287389278412,
0.012203601188957691,
0.03859231248497963,
0.1513577252626419,
-0.11288981884717941,
0.2580912709236145,
-0.17318294942378998,
0.2764299809932709,
-0.06051696836948395,
0.2882469892501831,
-0.0963679775595665,
-0.20057278871536255,
-0.0313657782971859,
-0.28505584597587585,
-0.21899864077568054,
0.08233408629894257,
-0.006465021055191755,
0.045670632272958755,
-0.012314306572079659,
-0.07223863154649734,
-0.17220036685466766,
-0.2979041635990143,
0.0031689689494669437,
0.1269191950559616,
-0.08240418881177902,
-0.29873496294021606,
-0.08390531688928604,
-0.02679116278886795,
-0.03847923502326012,
-0.21669510006904602,
0.05247250944375992,
0.15781669318675995
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. Persons with prolidase deficiency should have a normal hemoglobin electrophoretic pattern. β-thalassemia is caused by biallelic pathogenic variants in HBB and inherited in an autosomal recessive manner.Acquired causes of lower-extremity ulcers include arterial insufficiency, venous insufficiency, pressure ulcers, vasculitis, systemic lupus erythematosus, and infectious etiologies, among others. Although glycineprolinuria could be anticipated in cases of secondary skin ulcers given the high content of collagen in the dermis, a number of patients with extensive skin ulceration have been tested, and imidodipeptiduria was only found when accompanied by severe concurrent bone disease (e.g., multiple fractures) .Disorders with Hyper IgEAutosomal dominant hyper IgE syndrome (AD-HIES) is a primary immune deficiency syndrome characterized by the classic triad of recurrent skin boils, cyst-forming pneumonias, and extreme elevations of serum IgE. It is now recognized that other common manifestations include eczema, mucocutaneous candidiasis, and several | [
-0.23764830827713013,
-0.04922042414546013,
-0.1131904348731041,
-0.12995553016662598,
0.3009112477302551,
0.025850774720311165,
-0.002443725010380149,
-0.051776397973299026,
-0.23754644393920898,
-0.16561006009578705,
0.29014256596565247,
-0.03284034878015518,
0.24280066788196564,
0.15141050517559052,
-0.0396355576813221,
0.2308698445558548,
-0.0273189228028059,
0.14657820761203766,
-0.07769817858934402,
-0.04859767109155655,
-0.10401841253042221,
-0.034494657069444656,
0.017144689336419106,
0.21350686252117157,
0.2973928153514862,
0.10220492631196976,
-0.03212696313858032,
0.08250414580106735,
0.010917773470282555,
-0.031373560428619385,
-0.05994098633527756,
0.054633405059576035,
0.17317183315753937,
-0.1546199768781662,
0.11904185265302658,
-0.08135127276182175,
-0.26214441657066345,
-0.17716602981090546,
0.08569162338972092,
-0.041530855000019073,
-0.09164658933877945,
-0.15022467076778412,
0.07140925526618958,
-0.07053406536579132,
0.10291282087564468,
0.04391489550471306,
-0.06966785341501236,
-0.04291080683469772,
-0.08253680914640427,
-0.02016291953623295,
0.046432554721832275,
-0.07438510656356812,
0.09457480162382126,
0.01828783191740513,
0.05843046307563782,
-0.05992510914802551,
0.11334981769323349,
0.1584508717060089,
-0.08168363571166992,
0.16971200704574585,
0.010668191127479076,
-0.07170595973730087,
0.15372085571289062,
-0.3734986484050751,
0.1484721601009369,
-0.15641935169696808,
-0.10523006319999695,
0.12029954046010971,
-0.0015736306086182594,
0.1654643416404724,
0.3124488592147827,
0.08961650729179382,
0.018878400325775146,
0.08182776719331741,
-0.06247889623045921,
-0.28401729464530945,
0.1795129030942917,
0.0713980495929718,
0.0562785267829895,
-0.2669852674007416,
-0.2247212827205658,
0.14577171206474304,
0.08515044301748276,
0.17316089570522308,
-0.14122387766838074,
0.2795123755931854,
0.14626921713352203,
0.10634825378656387,
-0.03567222133278847,
-0.07437557727098465,
0.19362011551856995,
-0.12088803201913834,
0.1448959857225418,
-0.004240489564836025,
-0.013064936734735966,
-0.09430015087127686,
0.11961957812309265,
-0.1300167739391327,
-0.03137930855154991,
0.06271421164274216,
-0.11285900324583054,
0.12197015434503555,
0.03511930629611015,
0.07330487668514252,
0.08220113068819046,
-0.16534049808979034,
-0.2578354477882385,
-0.059020575135946274,
-0.28411030769348145,
-0.215984046459198,
0.008290558122098446,
-0.06530147790908813,
0.01982145383954048,
-0.008862778544425964,
-0.04188767820596695,
-0.013980718329548836,
-0.08612678945064545,
-0.10175032913684845,
-0.016184527426958084,
-0.03220156580209732,
-0.010555379092693329,
-0.0039943247102200985,
0.04782971367239952,
0.078408382833004,
0.25695574283599854,
0.2129499316215515,
0.11456923931837082,
0.07599426805973053,
0.35893714427948,
0.14238442480564117,
0.15521065890789032,
-0.23408202826976776,
-0.10853451490402222,
-0.2520121932029724,
-0.01621413044631481,
0.01209285669028759,
-0.12428099662065506,
-0.2788286507129669,
-0.0929236114025116,
-0.0031828053761273623,
-0.014810127206146717,
-0.04104498028755188,
0.16547584533691406,
0.2406298816204071,
-0.1471833437681198,
0.05335092172026634,
0.5114244818687439,
0.05601155012845993,
0.048633500933647156,
-0.05949966982007027,
0.14901146292686462,
-0.08126089721918106,
0.2913435995578766,
-0.09126085042953491,
-0.12145053595304489,
0.1713593453168869,
-0.3272765874862671,
0.1394747495651245,
-0.04179051145911217,
-0.24335242807865143,
0.02001979947090149,
-0.011281856335699558,
0.0823289081454277,
-0.3894151449203491,
-0.07864946126937866,
0.1066930890083313,
0.005908818915486336,
-0.1661706268787384,
0.23143576085567474,
0.05701733008027077,
0.1236145943403244,
-0.06253013014793396,
-0.21728749573230743,
0.20990997552871704,
0.3364560306072235,
-0.059412725269794464,
0.12901461124420166,
-0.03279761224985123,
-0.09042489528656006,
0.14427730441093445,
-0.09296795725822449,
0.016939787194132805,
-0.30434370040893555,
-0.11659852415323257,
0.08432392030954361,
-0.11989875882863998,
0.03083394654095173,
0.1809920221567154,
-0.012884032912552357,
0.07069218158721924,
0.12606853246688843,
0.0945848673582077,
-0.1587897092103958,
-0.026146849617362022,
-0.04409819841384888,
-0.2740683853626251,
0.060908302664756775,
-0.13985733687877655,
-0.056164778769016266,
-0.11975548416376114,
0.30653223395347595,
-0.2879909873008728,
0.12942741811275482,
0.07138406485319138,
0.15081638097763062,
0.04666560888290405,
-0.030915696173906326,
-0.002272400539368391,
0.09776267409324646,
0.2928394675254822,
-0.03328859433531761,
0.2261779010295868,
-0.06904486566781998,
0.07076907902956009,
-0.16606579720973969,
0.022792285308241844,
-0.2411998063325882,
-0.11676305532455444,
-0.05339033529162407,
-0.09987487643957138,
-0.13306808471679688,
-0.04189237579703331,
-0.007732804398983717,
-0.3323342800140381,
-0.03255647420883179,
0.053249988704919815,
-0.033066779375076294,
0.1438485085964203,
0.10734307020902634,
0.08858322352170944,
-0.18978920578956604,
0.12327611446380615,
0.03341051563620567,
0.09737633168697357,
-0.18049189448356628,
-0.20633858442306519,
-0.011793812736868858,
0.1375577598810196,
0.04760510474443436,
-0.04270106926560402,
-0.07427975535392761,
0.10306964069604874,
-0.04218977689743042,
-0.01672603003680706,
-0.020919855684041977,
0.04055865481495857,
-0.22545161843299866,
0.05832934007048607,
-0.12906281650066376,
0.014992760494351387,
-0.0532698929309845,
-0.20156912505626678,
0.22167202830314636,
0.0743911862373352,
-0.37003472447395325,
-0.22192907333374023,
0.08162863552570343,
-0.12402766942977905,
0.14421631395816803,
0.19971877336502075,
0.15729331970214844,
-0.08583077043294907,
0.09883721172809601,
0.16470004618167877,
-0.06918596476316452,
-0.1008710265159607,
-0.09885966777801514,
0.04098207503557205,
-0.11345316469669342,
-0.28180235624313354,
-0.06884922087192535,
0.15092098712921143,
0.27655184268951416,
-0.009939095936715603,
-0.12125071883201599,
-0.016432465985417366,
-0.052379462867975235,
0.0033395078498870134,
0.11006887257099152,
-0.0074255638755857944,
0.16410189867019653,
0.08539438992738724,
0.10714498162269592,
0.02977685071527958,
0.21658244729042053,
0.11522304266691208,
-0.10078605264425278,
0.16124999523162842,
-0.06364042311906815,
0.00872595515102148,
0.06794557720422745,
0.2203224152326584,
-0.08179649710655212,
0.0005928374012000859,
0.01891123503446579,
-0.09948267787694931,
-0.10864061862230301,
-0.13456124067306519,
0.26082202792167664,
0.05858100205659866,
0.11351717263460159,
0.13513720035552979,
-0.25730544328689575,
0.011078406125307083,
-0.0336742140352726,
0.02360006608068943,
0.2897185683250427,
0.08573585748672485,
-0.038798730820417404,
-0.05591357871890068,
-0.2004357874393463,
-0.09962731599807739,
0.01890048012137413,
-0.06884995102882385,
-0.11981935799121857,
-0.01587444543838501,
-0.08840025216341019,
0.003225575666874647,
0.016780609264969826,
-0.10555583238601685,
-0.014136020094156265,
0.023481084033846855,
0.05451725050806999,
0.35028210282325745,
-0.034298066049814224,
0.13930922746658325,
0.00663151778280735,
-0.11026426404714584,
-0.06536992639303207,
-0.08625954389572144,
0.04571564868092537,
0.04806722328066826,
0.03477556258440018,
0.1413872092962265,
-0.06340903788805008,
0.32536476850509644,
0.15499922633171082,
-0.032361406832933426,
-0.12401632219552994,
-0.22658413648605347,
0.04232977703213692,
-0.30214962363243103,
0.05073748528957367,
-0.21726979315280914,
0.02190650813281536,
0.1561419665813446,
0.1679036170244217,
0.1705046445131302,
0.11076278239488602,
-0.085812509059906,
-0.3033122718334198,
-0.08481749892234802,
0.003968076780438423,
-0.09161907434463501,
0.21432675421237946,
-0.052802637219429016,
-0.18016363680362701,
0.030864892527461052,
0.20589867234230042,
-0.15755033493041992,
-0.1283942610025406,
0.14808687567710876,
0.11774474382400513,
-0.10151746869087219,
0.21547438204288483,
0.13736692070960999,
0.009718833491206169,
0.16501329839229584,
0.03623005002737045,
-0.11387266218662262,
-0.057356689125299454,
-0.03267836198210716,
0.1236199364066124,
0.05652821063995361,
-0.2545298933982849,
-0.04899263381958008,
-0.036593008786439896,
0.10904548317193985,
-0.1690412312746048,
-0.006728335749357939,
-0.2132723480463028,
0.30329349637031555,
0.10876831412315369,
0.2646467983722687,
0.15697328746318817,
0.28801992535591125,
-0.023181818425655365,
0.24196863174438477,
-0.11718358844518661,
0.0011730121914297342,
0.26847198605537415,
0.1522350013256073,
0.14841493964195251,
0.13529439270496368,
-0.1844327598810196,
0.14845508337020874,
0.08184514194726944,
-0.07474376261234283,
-0.18912819027900696,
-0.05754915252327919,
-0.02232900634407997,
-0.06594192981719971,
0.3156118392944336,
0.27051129937171936,
0.24317428469657898,
0.1912502944469452,
-0.08798252791166306,
-0.00021274421305861324,
-0.07134255766868591,
0.08168650418519974,
0.004126603249460459,
-0.14493608474731445,
-0.15360958874225616,
-0.07326769828796387,
-0.035868771374225616,
-0.04312990978360176,
0.04924352839589119,
0.12563839554786682,
0.17752645909786224,
0.12696202099323273,
-0.15132640302181244,
-0.030024027451872826,
0.24898265302181244,
-0.07885333150625229,
-0.1116190180182457,
0.14427614212036133,
0.07513485848903656,
0.010765505954623222,
0.2047966718673706,
-0.008306008763611317,
0.11074744910001755,
0.21420706808567047,
0.04555986076593399,
0.015140208415687084,
0.28220653533935547,
0.03555180877447128,
-0.03434503450989723,
0.15599168837070465,
0.19601868093013763,
-0.0750139132142067,
0.2734128534793854,
-0.1161060556769371,
-0.017956601455807686,
-0.08291779458522797,
-0.08685505390167236,
0.026728766039013863,
-0.06418296694755554,
0.08751580119132996,
0.1677800714969635,
0.09231308102607727,
0.04470217600464821,
-0.10792415589094162,
0.2808760404586792,
0.011765561997890472,
-0.1501961648464203,
-0.04630472883582115,
-0.10083317756652832,
-0.2395133078098297,
-0.23553167283535004,
-0.013586698099970818,
-0.006447718013077974,
-0.061183515936136246,
0.0004594290512613952,
-0.13179466128349304,
0.10021694749593735,
0.24949613213539124,
-0.2858646512031555,
0.06257395446300507,
-0.11728240549564362,
0.14315086603164673,
0.0982683077454567,
0.044567983597517014,
0.20706352591514587,
-0.007199198938906193,
0.00644509494304657,
-0.17181698977947235,
0.05056215450167656,
0.12399286776781082,
-0.07409049570560455,
0.23225848376750946,
-0.03341521695256233,
0.038807693868875504,
-0.2069389820098877,
0.06664077937602997,
0.1333220899105072,
-0.05121201276779175,
0.2372196614742279,
-0.26538577675819397,
0.17696216702461243,
-0.05061223357915878,
0.055584922432899475,
0.08857372403144836,
-0.03159315884113312,
0.3526209890842438,
0.07487515360116959,
0.06747697293758392,
-0.02242659591138363,
-0.16133198142051697,
0.044318124651908875,
-0.1848834604024887,
0.1870311200618744,
-0.11142352223396301,
-0.025689903646707535,
0.2653944492340088,
0.017465440556406975,
-0.13586290180683136,
0.07526378333568573,
-0.23737722635269165,
0.03936750441789627,
0.2299455851316452,
0.22605746984481812,
-0.03377189859747887,
-0.09300702065229416,
-0.23031045496463776,
0.04772656783461571,
-0.13625553250312805,
0.00312003749422729,
0.1261766254901886,
0.289747416973114,
0.06682920455932617,
-0.054206982254981995,
-0.1378210335969925,
0.056255538016557693,
0.1429266333580017,
-0.04033493623137474,
-0.15654531121253967,
0.04459110274910927,
-0.06203313171863556,
-0.3295882046222687,
-0.03179583325982094,
0.05204196646809578,
-0.17717377841472626,
-0.10044367611408234,
-0.04382375255227089,
0.11368252336978912,
-0.1982107311487198,
-0.01601511240005493,
-0.01286538876593113,
0.008173873648047447,
-0.07465974241495132,
-0.14792831242084503,
-0.052018504589796066,
-0.12772390246391296,
0.126443549990654,
-0.12267902493476868,
0.01807587593793869,
0.021550452336668968,
0.1334618628025055,
0.0666612833738327,
0.03749758377671242,
0.058647166937589645,
-0.14048784971237183,
-0.02306409925222397,
0.14501693844795227,
0.06373946368694305,
-0.007543215528130531,
0.06827118992805481,
-0.11065038293600082,
-0.0534253753721714,
0.04126584157347679,
0.058534566313028336,
0.07879599183797836,
0.05972188711166382,
0.07330907136201859,
-0.045672036707401276,
0.1274336576461792,
-0.0972028374671936,
-0.024975471198558807,
-0.08664513379335403,
-0.23724541068077087,
-0.09179501235485077,
0.10638882964849472,
0.019847271963953972,
-0.21852371096611023,
-0.1070161908864975,
-0.2103653848171234,
-0.13019423186779022,
-0.039676010608673096,
-0.07727739214897156,
0.10328828543424606,
-0.07462801784276962,
-0.0365341454744339,
0.1713830530643463,
-0.1029137372970581,
-0.09203822910785675,
-0.054955147206783295,
0.020296847447752953,
0.08166924864053726,
0.11574647575616837,
0.11151309311389923,
0.28248298168182373,
-0.161499485373497,
0.06970042735338211,
-0.129103884100914,
0.17845706641674042,
0.050198063254356384,
0.12838226556777954,
-0.2521117627620697,
-0.05891938880085945,
-0.06227676570415497,
0.23412346839904785,
0.07858675718307495,
-0.2674741744995117,
-0.03883204609155655,
-0.15813666582107544,
0.00118624372407794,
0.045565973967313766,
-0.1471458375453949,
0.1784859150648117,
0.15687061846256256,
-0.09485577791929245,
0.11597555875778198,
0.13545194268226624,
0.09291010349988937,
0.1942656934261322,
-0.11388102173805237,
-0.012012937106192112,
-0.26208868622779846,
-0.1503569483757019,
-0.05236074700951576,
0.08868660777807236,
-0.15197783708572388,
0.23967766761779785,
-0.09887770563364029,
-0.10125435888767242,
0.11748266220092773,
-0.04207267984747887,
-0.1764577180147171,
0.06857803463935852,
-0.038035377860069275,
0.040892258286476135,
-0.09663645923137665,
-0.11301685869693756,
0.10373435169458389,
-0.11916667222976685,
0.26172199845314026,
0.143469899892807,
0.28273308277130127,
-0.1482590287923813,
-0.014455869793891907,
-0.000925017986446619,
-0.15918292105197906,
-0.16442954540252686,
0.12505507469177246,
-0.06599301844835281,
0.290466845035553,
-0.03552108630537987,
-0.3341740667819977,
0.10732617229223251,
-0.118135467171669,
0.22991938889026642,
0.03558194637298584,
0.0034312389325350523,
-0.012109201401472092,
-0.035775650292634964,
0.043286122381687164,
0.1672201007604599,
-0.21141517162322998,
-0.012887083925306797,
-0.16029463708400726,
0.15301787853240967,
-0.008959447033703327,
-0.2127271294593811,
-0.07165194302797318,
-0.09774839878082275,
-0.1593277007341385,
0.11702405661344528,
-0.2576446235179901,
0.09078262746334076,
-0.11770763993263245,
0.14850948750972748,
0.21873806416988373,
-0.04157332703471184,
0.032412685453891754,
0.10771314054727554,
0.04105672240257263,
-0.12729355692863464,
-0.12461062520742416,
-0.15342649817466736,
0.3116030693054199,
-0.07350217550992966,
-0.2528435289859772,
0.0015585303772240877,
0.02286183461546898,
-0.043677087873220444,
0.02691766619682312,
0.02951488085091114,
-0.0021088074427098036,
0.08469442278146744,
-0.12376715242862701,
-0.1225048303604126,
-0.15236526727676392,
0.02163221873342991,
0.0558074451982975,
-0.17764171957969666,
-0.19969376921653748,
0.33056020736694336,
0.12159621715545654,
0.06091232970356941,
-0.08795896172523499,
0.12072765082120895,
0.01250139158219099,
-0.0009658606722950935,
0.06972266733646393,
0.07780871540307999,
0.1731933057308197,
-0.06454171985387802,
0.0018268647836521268,
-0.06575057655572891,
-0.02059047855436802,
0.006058219354599714,
-0.021954620257019997,
-0.049319468438625336,
0.18338865041732788,
0.032314278185367584,
0.17785686254501343,
-0.21429568529129028,
-0.10568154603242874,
-0.07009527087211609,
0.22003184258937836,
-0.07672100514173508,
0.2238725870847702,
0.12167132645845413,
-0.17239174246788025,
0.03520886227488518,
0.18933209776878357,
0.21874938905239105,
0.01896907016634941,
0.0852130651473999,
-0.037726569920778275,
-0.1256645917892456,
-0.23796965181827545,
-0.008585451170802116,
0.24625049531459808,
-0.05566804111003876,
0.05253695696592331,
-0.035698164254426956,
-0.18004822731018066,
0.0467793308198452,
0.12825478613376617,
-0.1143903061747551,
0.1666467785835266,
-0.12671345472335815,
0.13067923486232758,
0.06654463708400726,
0.09304824471473694,
-0.01992826536297798,
-0.17045201361179352,
-0.27054861187934875,
-0.07860107719898224,
-0.1246664896607399,
0.0911942571401596,
0.06780773401260376,
-0.02417483553290367,
0.14001555740833282,
-0.0623650848865509,
-0.20033757388591766,
-0.09447307884693146,
0.03622647747397423,
0.22347453236579895,
-0.06661288440227509,
-0.009623900055885315,
0.012646290473639965,
-0.006205399055033922,
-0.06747560948133469,
0.1318787783384323,
0.09268118441104889,
0.13509362936019897
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. extensive skin ulceration have been tested, and imidodipeptiduria was only found when accompanied by severe concurrent bone disease (e.g., multiple fractures) .Disorders with Hyper IgEAutosomal dominant hyper IgE syndrome (AD-HIES) is a primary immune deficiency syndrome characterized by the classic triad of recurrent skin boils, cyst-forming pneumonias, and extreme elevations of serum IgE. It is now recognized that other common manifestations include eczema, mucocutaneous candidiasis, and several connective tissue and skeletal abnormalities like osteopenia, minimal trauma fractures, and scoliosis. AD-HIES is caused by mutation of STAT3. A Grimbacher score of >40 is suggestive of AD-HIES.Autosomal recessive hyper IgE syndrome (AR-HIES) (OMIM 243700) is a distinct clinical disorder, characterized by elevated serum concentration of IgE, severe eczema, and recurrent skin and lung infections , all of which can also be seen | [
-0.39197489619255066,
-0.13050583004951477,
0.02768193557858467,
-0.06334255635738373,
0.135463148355484,
-0.08326856791973114,
0.04190724715590477,
-0.028757676482200623,
-0.2904563844203949,
-0.1747485250234604,
0.26373744010925293,
-0.14899300038814545,
-0.044642288237810135,
0.16022104024887085,
-0.030072199180722237,
0.16297799348831177,
-0.009930298663675785,
0.1267799735069275,
0.023631267249584198,
0.17110949754714966,
0.02473585680127144,
0.13982059061527252,
0.04670536890625954,
0.19945764541625977,
0.25696316361427307,
-0.1991175264120102,
-0.08397352695465088,
-0.06618693470954895,
0.22911998629570007,
0.016102641820907593,
0.055196210741996765,
0.21004390716552734,
-0.033180270344018936,
-0.17585605382919312,
0.10573641210794449,
-0.1023898720741272,
-0.04543912783265114,
-0.13527613878250122,
-0.17710641026496887,
-0.20057082176208496,
-0.13563649356365204,
-0.22259962558746338,
-0.14831827580928802,
-0.15477637946605682,
0.049991074949502945,
0.028940429911017418,
-0.05301681533455849,
-0.03837217763066292,
-0.27528485655784607,
-0.14284412562847137,
-0.035884127020835876,
0.08782923221588135,
0.08345440775156021,
0.05955522879958153,
0.09876560419797897,
-0.09559622406959534,
-0.04653127118945122,
0.1941760927438736,
-0.1966473013162613,
0.25104331970214844,
-0.21775251626968384,
-0.2977287471294403,
0.16274394094944,
-0.3570978343486786,
0.04332540184259415,
-0.06017144024372101,
-0.012416074052453041,
0.1579039841890335,
0.10880368947982788,
0.05914115905761719,
0.1856318563222885,
0.20073853433132172,
0.034478265792131424,
0.0346723310649395,
-0.025812825188040733,
-0.11235290765762329,
-0.03921909257769585,
0.07021242380142212,
0.04128703847527504,
-0.256107896566391,
-0.18193481862545013,
0.39510685205459595,
-0.0992458313703537,
0.23313993215560913,
-0.1274784356355667,
0.12732432782649994,
0.16941781342029572,
0.007607453037053347,
-0.056184571236371994,
0.02298690751194954,
0.23393909633159637,
-0.05323566496372223,
0.01844830997288227,
-0.04573707655072212,
-0.05205758288502693,
-0.06898177415132523,
0.03709820657968521,
-0.10948994755744934,
-0.06766536086797714,
0.027116524055600166,
-0.15316447615623474,
0.13290181756019592,
-0.03659405559301376,
0.1704675853252411,
-0.07805962860584259,
-0.2190539389848709,
-0.20553995668888092,
-0.07826951891183853,
-0.21568845212459564,
-0.2103840857744217,
0.23570603132247925,
0.08976852893829346,
0.16286228597164154,
0.26323413848876953,
0.022443614900112152,
0.07494301348924637,
-0.15040463209152222,
-0.023049630224704742,
-0.17314252257347107,
0.009771808050572872,
-0.008921043016016483,
0.04770023748278618,
0.12248095870018005,
0.029461462050676346,
0.20610323548316956,
0.21453021466732025,
-0.025132393464446068,
-0.18637967109680176,
0.47587350010871887,
0.010648226365447044,
0.06253392994403839,
-0.14834479987621307,
-0.25694918632507324,
-0.12542885541915894,
0.11794905364513397,
-0.027472523972392082,
-0.10735046863555908,
-0.37771880626678467,
-0.06982550024986267,
-0.07109105587005615,
-0.05129215493798256,
0.16786590218544006,
0.21403919160366058,
0.23841850459575653,
-0.05332079157233238,
0.07387609034776688,
0.5545075535774231,
-0.07262488454580307,
-0.014038287103176117,
0.08545127511024475,
0.13163593411445618,
-0.0806950107216835,
0.20529933273792267,
-0.15733064711093903,
-0.15651559829711914,
0.14080464839935303,
-0.30095356702804565,
0.20528282225131989,
0.037211429327726364,
-0.07732997834682465,
-0.10295170545578003,
-0.006997986230999231,
-0.049127161502838135,
-0.6673547029495239,
-0.11942470073699951,
-0.0072916834615170956,
0.16890718042850494,
-0.166655495762825,
0.22417210042476654,
-0.045512501150369644,
0.17471857368946075,
-0.11257479339838028,
-0.323361337184906,
0.15266506373882294,
0.2651512324810028,
-0.0069238715805113316,
0.11824274063110352,
-0.20073561370372772,
0.07242192327976227,
0.14456717669963837,
-0.120688296854496,
-0.0312645398080349,
-0.30128440260887146,
-0.059231601655483246,
0.12354602664709091,
-0.4417085647583008,
0.1690026819705963,
0.16249389946460724,
0.1508389711380005,
0.06086743623018265,
0.22897909581661224,
0.19452866911888123,
-0.15074509382247925,
-0.07181398570537567,
-0.07271020114421844,
-0.3797602355480194,
0.08193108439445496,
-0.2754615247249603,
-0.0004414135473780334,
0.09812632203102112,
0.09032980352640152,
-0.21190065145492554,
0.11423320323228836,
0.060476113110780716,
0.10687310248613358,
0.021902013570070267,
0.07646986097097397,
0.029272908344864845,
0.1425623893737793,
0.3457041382789612,
-0.08294952660799026,
0.3466516137123108,
0.019549598917365074,
0.08263713866472244,
-0.12157036364078522,
0.09120035171508789,
-0.1373373419046402,
-0.14757561683654785,
0.007700126618146896,
-0.11577315628528595,
-0.04675407335162163,
0.02468673326075077,
0.04072006791830063,
-0.3996424376964569,
-0.02890106663107872,
0.11456262320280075,
-0.037187185138463974,
-0.0880742222070694,
0.1423012763261795,
0.04383069649338722,
-0.12623849511146545,
-0.07061818242073059,
-0.008113212883472443,
0.06818176805973053,
-0.08350785821676254,
-0.29358747601509094,
0.1566881388425827,
0.05711265653371811,
0.041256580501794815,
-0.035818006843328476,
-0.09106774628162384,
-0.17495310306549072,
0.055646028369665146,
0.013601575046777725,
-0.11421232670545578,
-0.08673275262117386,
-0.07047978043556213,
-0.0008823042153380811,
0.06202935054898262,
-0.025142449885606766,
-0.03907552361488342,
-0.0710417851805687,
0.1210285946726799,
0.08713522553443909,
-0.24517445266246796,
-0.19337180256843567,
-0.08041739463806152,
-0.17900845408439636,
0.10792654007673264,
0.1729355901479721,
0.12443984299898148,
0.15849143266677856,
0.14736084640026093,
0.2216135710477829,
0.00522293895483017,
-0.1532844454050064,
0.11735322326421738,
-0.01522333174943924,
-0.0021477555856108665,
0.0067662522196769714,
-0.1308363974094391,
0.26182088255882263,
0.19395668804645538,
0.007611743174493313,
-0.1448821723461151,
-0.0048193419352173805,
0.05465012043714523,
-0.13757428526878357,
0.19182699918746948,
-0.013188430108129978,
0.09117583185434341,
0.012637093663215637,
-0.07452385872602463,
-0.03195846080780029,
0.24601729214191437,
0.10776979476213455,
-0.03547021374106407,
0.09170526266098022,
-0.09640492498874664,
-0.023389240726828575,
-0.10726988315582275,
-0.045359037816524506,
-0.009267644956707954,
0.10617627948522568,
-0.006446962244808674,
-0.03283090889453888,
0.023251978680491447,
-0.16556715965270996,
0.2889782786369324,
-0.032371994107961655,
0.16395767033100128,
0.18991005420684814,
-0.24030029773712158,
-0.05476002022624016,
0.027061592787504196,
0.19774946570396423,
0.24363021552562714,
0.1273423433303833,
-0.15603145956993103,
-0.16801171004772186,
-0.3381459414958954,
-0.10916956514120102,
0.16478469967842102,
0.09438628703355789,
0.06124705448746681,
-0.06751187145709991,
-0.028086112812161446,
0.13390104472637177,
0.13624036312103271,
-0.08825569599866867,
-0.12725916504859924,
0.13356563448905945,
-0.08406591415405273,
0.30751219391822815,
-0.0746174082159996,
0.09189511090517044,
0.02388974279165268,
0.03237878158688545,
-0.22035139799118042,
-0.026163944974541664,
0.01616121269762516,
-0.03813279792666435,
0.07434579730033875,
0.029675068333745003,
-0.23311974108219147,
0.1599927693605423,
0.20057626068592072,
0.02762790210545063,
-0.04204899072647095,
0.08529616892337799,
0.06901755183935165,
-0.4187657833099365,
0.012401444837450981,
-0.08178246021270752,
0.06692847609519958,
0.08178690820932388,
0.03379163146018982,
-0.01623684912919998,
0.1333063542842865,
-0.2337016761302948,
-0.3008670508861542,
0.09502142667770386,
-0.16305013000965118,
-0.12517845630645752,
0.04317706078290939,
-0.053321607410907745,
-0.1234067752957344,
0.06912203878164291,
0.15264812111854553,
-0.09465819597244263,
-0.2230503112077713,
-0.061174821108579636,
-0.12804268300533295,
0.06548366695642471,
0.03446362912654877,
0.1880868524312973,
-0.22559373080730438,
0.23985733091831207,
0.08474952727556229,
0.03872867673635483,
-0.046709269285202026,
0.03969356417655945,
0.2627207636833191,
-0.1325608640909195,
-0.29181942343711853,
-0.14572195708751678,
0.0318806990981102,
0.06420954316854477,
-0.22271008789539337,
-0.17820759117603302,
-0.2578750252723694,
0.18717800080776215,
-0.012935742735862732,
0.23582521080970764,
0.17456868290901184,
0.02258479781448841,
0.011208784766495228,
0.07448913902044296,
-0.2541482448577881,
0.0903325006365776,
0.19418630003929138,
-0.0037558318581432104,
0.048789892345666885,
0.1032419502735138,
-0.07384611666202545,
-0.035711657255887985,
0.10519785434007645,
-0.16661831736564636,
-0.3214561343193054,
0.009758206084370613,
-0.17886203527450562,
0.0748840942978859,
0.24956700205802917,
0.33218303322792053,
0.2482154667377472,
0.218034029006958,
-0.09856802970170975,
-0.11510632932186127,
-0.05595683678984642,
0.058104902505874634,
-0.2026335746049881,
-0.10860131680965424,
-0.18663017451763153,
-0.1607167273759842,
-0.016850300133228302,
0.0756063163280487,
0.21793867647647858,
0.16855700314044952,
0.20964796841144562,
0.2022245079278946,
0.030152861028909683,
0.023703603073954582,
0.2575676441192627,
0.059270668774843216,
-0.03540241718292236,
-0.07850129902362823,
0.18935291469097137,
-0.1480572670698166,
0.11794088780879974,
0.015637991949915886,
-0.01559442188590765,
0.24035170674324036,
-0.11276158690452576,
-0.1355612576007843,
0.019802646711468697,
-0.04886237159371376,
0.208578422665596,
0.09315958619117737,
0.16077059507369995,
-0.21437951922416687,
0.23099717497825623,
-0.29988226294517517,
-0.061810754239559174,
-0.015730950981378555,
0.03357867896556854,
0.021907294169068336,
-0.023440437391400337,
-0.08298168331384659,
0.12568113207817078,
0.07378300279378891,
0.0019655562937259674,
-0.07632520794868469,
0.24559612572193146,
0.033915046602487564,
-0.13652247190475464,
-0.028247574344277382,
0.12509170174598694,
-0.2406211495399475,
-0.07265063375234604,
-0.1496456414461136,
0.06025458127260208,
-0.21566131711006165,
-0.08477549254894257,
-0.11233790218830109,
0.2097388505935669,
0.35454514622688293,
-0.3539993166923523,
-0.19201627373695374,
-0.15201245248317719,
0.06711051613092422,
0.0572018064558506,
-0.07316751033067703,
0.00788427796214819,
-0.11488845944404602,
-0.04851488769054413,
-0.448874294757843,
-0.0037880954332649708,
0.029855899512767792,
-0.052304647862911224,
0.08812103420495987,
-0.11783129721879959,
-0.011240455321967602,
-0.12145833671092987,
0.20293202996253967,
0.25149402022361755,
-0.07446330785751343,
0.3132270276546478,
0.012988054193556309,
0.022984154522418976,
0.03836037963628769,
-0.024069769307971,
-0.03292768448591232,
0.053288813680410385,
0.14382660388946533,
0.10398049652576447,
0.0606977678835392,
-0.10353057831525803,
0.031230034306645393,
0.08368486166000366,
-0.045756470412015915,
0.01029041688889265,
-0.07456651329994202,
0.11174819618463516,
0.017718838527798653,
0.08433839678764343,
-0.020350618287920952,
0.2583494782447815,
-0.19101858139038086,
-0.120453380048275,
0.2182699739933014,
0.27149298787117004,
0.1648726463317871,
-0.11879047006368637,
-0.2817135751247406,
0.12778083980083466,
-0.061359845101833344,
-0.005398518871515989,
0.2866896092891693,
0.2592798173427582,
0.0795055478811264,
-0.04925976321101189,
-0.40863269567489624,
-0.02674652449786663,
0.05213475599884987,
0.08684832602739334,
-0.30494245886802673,
0.19552142918109894,
-0.09915826469659805,
-0.06013873592019081,
-0.01097758300602436,
-0.002390136942267418,
-0.08656516671180725,
-0.3048611283302307,
0.03570066764950752,
0.16335341334342957,
-0.04479493945837021,
-0.03358796611428261,
0.17338232696056366,
-0.26197800040245056,
-0.21627677977085114,
-0.1220134049654007,
0.21909251809120178,
-0.05604816600680351,
0.017526187002658844,
-0.0006539907772094011,
0.09525880217552185,
-0.11708459258079529,
0.11508847028017044,
0.1526515632867813,
-0.1560661792755127,
0.14529401063919067,
-0.15988478064537048,
0.07150575518608093,
-0.03298747539520264,
0.017648568376898766,
0.08885962516069412,
0.10830049216747284,
-0.12825709581375122,
0.018680132925510406,
0.14584900438785553,
0.0021273489110171795,
0.07223310321569443,
-0.08507806062698364,
0.0000969949978752993,
-0.0886920690536499,
0.009240133687853813,
0.08017127215862274,
-0.04273393005132675,
-0.08133745193481445,
-0.1240449771285057,
-0.2372908890247345,
-0.07093536108732224,
0.09055567532777786,
-0.06447384506464005,
0.08207642287015915,
-0.15315720438957214,
-0.15996620059013367,
-0.23709997534751892,
-0.017611991614103317,
0.04921700060367584,
-0.09530242532491684,
-0.033402178436517715,
-0.028871363028883934,
0.015441506169736385,
0.07358129322528839,
0.06168214976787567,
-0.05511990934610367,
-0.022110100835561752,
0.05576807260513306,
-0.041636593639850616,
0.3042427599430084,
-0.17198532819747925,
0.08483736217021942,
-0.05663760378956795,
0.1442563533782959,
-0.010987398214638233,
0.21660736203193665,
-0.041319891810417175,
-0.23983551561832428,
-0.12642650306224823,
0.17192402482032776,
0.07695452868938446,
-0.22588181495666504,
0.0039880163967609406,
0.01954028382897377,
-0.04800504818558693,
0.0052688526920974255,
-0.25293949246406555,
0.09994623810052872,
0.0978991910815239,
-0.23937095701694489,
-0.027495279908180237,
-0.019516652449965477,
0.1099843755364418,
0.1033773273229599,
-0.11177890747785568,
-0.025362487882375717,
-0.0813683345913887,
-0.11573731154203415,
-0.2998288571834564,
0.06084466725587845,
-0.21612903475761414,
0.21699029207229614,
-0.04578359052538872,
0.048601675778627396,
0.2320566624403,
0.0604991614818573,
-0.33391159772872925,
-0.04556974768638611,
-0.060153134167194366,
0.03482413291931152,
-0.04963386803865433,
-0.20046517252922058,
0.03956166282296181,
0.05292072519659996,
0.025753704831004143,
-0.09061680734157562,
0.29444923996925354,
0.1351185292005539,
0.06783057749271393,
-0.2197171002626419,
-0.1827254444360733,
-0.21277697384357452,
0.05190976336598396,
-0.1458497941493988,
0.13301999866962433,
-0.1634511500597,
-0.38900473713874817,
0.07134009897708893,
-0.025777067989110947,
0.24433425068855286,
0.19708581268787384,
0.1335912048816681,
-0.06161101534962654,
0.05879640951752663,
0.03713732957839966,
0.19512560963630676,
-0.055938709527254105,
-0.04384917765855789,
-0.09519359469413757,
0.02934562973678112,
-0.02642296440899372,
-0.22788958251476288,
-0.17002712190151215,
-0.20095941424369812,
-0.25006571412086487,
-0.19496247172355652,
-0.18446940183639526,
0.3414902091026306,
-0.15136310458183289,
0.14383654296398163,
0.40601420402526855,
0.042161017656326294,
-0.04554353281855583,
0.1424197107553482,
0.018151257187128067,
-0.012317202985286713,
-0.08753705769777298,
0.09328585118055344,
0.2982389032840729,
-0.10788741707801819,
-0.32557186484336853,
0.13007846474647522,
0.15330466628074646,
0.14015623927116394,
-0.014638650231063366,
-0.028291000053286552,
-0.1529466062784195,
-0.09679243713617325,
0.06685339659452438,
-0.16160255670547485,
-0.14279882609844208,
-0.13220727443695068,
0.032104454934597015,
-0.04753398150205612,
-0.03822443634271622,
0.41944560408592224,
0.031790997833013535,
0.12251561880111694,
-0.10315673053264618,
0.16751453280448914,
0.3127664029598236,
0.16489799320697784,
0.0043752435594797134,
-0.030888579785823822,
0.14185810089111328,
-0.13200056552886963,
-0.08869589120149612,
-0.1517581045627594,
-0.15621335804462433,
0.04268879443407059,
0.02203868143260479,
-0.08257643133401871,
0.10865943133831024,
0.014074995182454586,
0.26801779866218567,
-0.17490531504154205,
-0.08616586774587631,
-0.14127829670906067,
0.11541132628917694,
0.04886847361922264,
0.05067841336131096,
-0.07796220481395721,
-0.18514718115329742,
0.08381271362304688,
0.32590252161026,
0.28230249881744385,
0.3304476737976074,
-0.03440285101532936,
-0.14299902319908142,
0.061826884746551514,
-0.21414609253406525,
-0.08701532334089279,
0.11561881005764008,
-0.0213894322514534,
0.07513649761676788,
0.0489162877202034,
-0.2597777545452118,
-0.01926151104271412,
-0.0019267103634774685,
-0.2866690754890442,
0.173054501414299,
0.0024845071602612734,
0.147578626871109,
0.07014676183462143,
0.0635206326842308,
-0.0002960202400572598,
-0.2660444378852844,
-0.19815099239349365,
0.2292352169752121,
0.0069970255717635155,
0.07459928840398788,
0.16152870655059814,
0.04063147306442261,
0.22985364496707916,
0.04523824527859688,
-0.20544837415218353,
-0.24613213539123535,
-0.0569230355322361,
0.19724349677562714,
0.0040589589625597,
0.09931379556655884,
0.12243007123470306,
0.029098019003868103,
0.036957014352083206,
0.13923585414886475,
0.05796720087528229,
0.18105798959732056
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. eous candidiasis, and several connective tissue and skeletal abnormalities like osteopenia, minimal trauma fractures, and scoliosis. AD-HIES is caused by mutation of STAT3. A Grimbacher score of >40 is suggestive of AD-HIES.Autosomal recessive hyper IgE syndrome (AR-HIES) (OMIM 243700) is a distinct clinical disorder, characterized by elevated serum concentration of IgE, severe eczema, and recurrent skin and lung infections , all of which can also be seen in prolidase deficiency. Prolidase deficiency differs from AD-HIES by an increased incidence of neurologic abnormalities, an increased occurrence of viral infections of the skin (e.g., Molluscum contagiosum, warts) and virus-driven malignancies, as well as absence of the non-immunologic findings of AD-HIES (e.g., connective tissue, skeletal and dental involvement) . AR-HIES is caused by biallelic pathogenic | [
-0.286933571100235,
0.02403167262673378,
0.14939405024051666,
-0.045107994228601456,
0.06402166932821274,
0.01571648381650448,
0.03681100159883499,
-0.050993070006370544,
-0.19321991503238678,
-0.20701204240322113,
0.23562487959861755,
-0.010722874663770199,
0.008942251093685627,
0.04599201679229736,
-0.12058603763580322,
0.028584102168679237,
-0.008726920932531357,
-0.02472943812608719,
0.011162377893924713,
0.05760817974805832,
0.04179548844695091,
-0.04589717462658882,
0.25788408517837524,
0.15067851543426514,
0.3033974766731262,
-0.13900065422058105,
-0.009045770391821861,
-0.03777909651398659,
0.1646217405796051,
0.15307699143886566,
0.08559723943471909,
0.14333732426166534,
-0.061244845390319824,
-0.1222899928689003,
0.1315775364637375,
-0.009873495437204838,
-0.04923072084784508,
-0.051587674766778946,
0.06354027986526489,
-0.28597691655158997,
-0.10445848107337952,
-0.020259814336895943,
-0.13462550938129425,
-0.02283708192408085,
0.07239920645952225,
-0.02623388171195984,
-0.02803957089781761,
0.08818745613098145,
-0.3243485987186432,
-0.0037375858519226313,
0.0802098959684372,
0.014889783225953579,
0.0032460400834679604,
-0.06117992103099823,
0.2268189936876297,
0.019291400909423828,
-0.0862942785024643,
0.21889030933380127,
-0.19618017971515656,
0.20624209940433502,
-0.07571309059858322,
-0.3222670555114746,
-0.0001138850930146873,
-0.37843000888824463,
0.15794767439365387,
-0.03176193684339523,
0.02705513872206211,
-0.012678286992013454,
-0.0365438312292099,
0.009659607894718647,
0.29443803429603577,
0.1095198318362236,
0.15053699910640717,
0.07085806131362915,
-0.13719137012958527,
-0.13453401625156403,
-0.0307461004704237,
-0.009180768392980099,
-0.0076514785178005695,
-0.222666397690773,
-0.1596020609140396,
0.3550425171852112,
-0.13394494354724884,
0.2031237781047821,
0.012152006849646568,
0.3225361108779907,
0.27779772877693176,
0.10244201123714447,
0.11672425270080566,
0.035059332847595215,
0.16178680956363678,
-0.16738060116767883,
0.07519295066595078,
-0.13377317786216736,
-0.10270465165376663,
-0.10387961566448212,
0.04595835134387016,
-0.14407001435756683,
-0.06566160172224045,
0.10966465622186661,
0.02052050456404686,
0.004800081718713045,
0.030425066128373146,
0.12575097382068634,
0.10150977969169617,
-0.07847816497087479,
-0.14625869691371918,
-0.057029061019420624,
-0.21126502752304077,
-0.13625958561897278,
0.189500629901886,
0.18947234749794006,
0.011881024576723576,
0.15170013904571533,
0.0458320789039135,
0.08388156443834305,
0.045513782650232315,
-0.09897670149803162,
0.060350202023983,
-0.0650734081864357,
-0.10777457803487778,
0.14490924775600433,
0.1298903524875641,
-0.039866577833890915,
0.0891529992222786,
0.2321372926235199,
-0.04192541539669037,
-0.036407675594091415,
0.36687108874320984,
-0.0150575190782547,
0.0448450930416584,
-0.03637446090579033,
-0.143805593252182,
-0.07185740768909454,
-0.11272098869085312,
0.0268589835613966,
-0.24666139483451843,
-0.21748055517673492,
-0.07632797956466675,
-0.13815201818943024,
0.07449439913034439,
0.019244901835918427,
0.17761923372745514,
0.34301966428756714,
0.020048784092068672,
0.09681954979896545,
0.42297136783599854,
-0.000423628807766363,
-0.01974332705140114,
0.015689792111516,
0.05476309731602669,
-0.09355436265468597,
0.4136650264263153,
-0.10607857257127762,
-0.08679131418466568,
0.15956807136535645,
-0.22527219355106354,
0.14380572736263275,
-0.06282369047403336,
0.0728875920176506,
0.05431206896901131,
-0.045888468623161316,
-0.02934814617037773,
-0.38983044028282166,
0.020454369485378265,
0.015827547758817673,
0.004995452240109444,
-0.10784029960632324,
0.1301829069852829,
-0.05926664173603058,
0.05059749633073807,
-0.07924339175224304,
-0.20535480976104736,
0.15597140789031982,
0.1662432998418808,
-0.1584051549434662,
0.020374538376927376,
0.0214551892131567,
0.1177271157503128,
0.05809146165847778,
-0.018482673913240433,
-0.07989748567342758,
-0.16330403089523315,
-0.06627225130796432,
-0.008063078857958317,
-0.26042047142982483,
0.24978868663311005,
0.19902196526527405,
0.08727087080478668,
-0.03580436855554581,
0.24060165882110596,
0.12328532338142395,
-0.1289331167936325,
-0.10666435211896896,
0.1773984283208847,
-0.365153431892395,
0.17182676494121552,
-0.23460079729557037,
-0.028418539091944695,
-0.05283359810709953,
0.15022537112236023,
-0.38387832045555115,
0.09758805483579636,
0.10198767483234406,
-0.05340498685836792,
0.12270648032426834,
-0.11302492022514343,
-0.05391794815659523,
0.04122865945100784,
0.4040396511554718,
0.036193158477544785,
0.28823283314704895,
0.06694275140762329,
0.16344064474105835,
-0.18480509519577026,
0.09392998367547989,
-0.21371003985404968,
-0.16942937672138214,
0.0196123905479908,
-0.18764816224575043,
0.014015473425388336,
0.08162300288677216,
0.03502551466226578,
-0.33215463161468506,
-0.0053533269092440605,
0.21866890788078308,
-0.02898603305220604,
-0.015216468833386898,
-0.04212842509150505,
0.12046322971582413,
-0.12545573711395264,
0.005614015273749828,
0.06274144351482391,
0.11366485804319382,
-0.16817840933799744,
-0.19192169606685638,
0.1568833738565445,
0.04028113931417465,
0.17425161600112915,
-0.02425074577331543,
-0.3194767236709595,
0.022205762565135956,
-0.011045671999454498,
-0.04547920450568199,
-0.19569900631904602,
0.13246341049671173,
-0.21558132767677307,
0.036528579890728,
0.09732037037611008,
-0.06395325809717178,
-0.07514572888612747,
-0.025506723672151566,
0.10318021476268768,
-0.03578605502843857,
-0.5362944602966309,
-0.07213042676448822,
0.10637418180704117,
-0.17125171422958374,
0.12253071367740631,
0.06026535481214523,
0.14329175651073456,
0.005242799874395132,
0.12409588694572449,
0.17779287695884705,
0.07416091114282608,
-0.0065207211300730705,
-0.06304517388343811,
0.031083278357982635,
-0.09700587391853333,
-0.056551363319158554,
-0.0540945939719677,
0.0652584508061409,
0.11564196646213531,
0.10014767944812775,
-0.18347905576229095,
-0.06955750286579132,
-0.15585917234420776,
-0.006975730415433645,
0.18976494669914246,
-0.102230004966259,
-0.012730752117931843,
-0.060170192271471024,
-0.07609391212463379,
0.022955551743507385,
0.23205852508544922,
0.021267812699079514,
0.13739226758480072,
0.054542191326618195,
-0.24726828932762146,
-0.051972661167383194,
0.04496094211935997,
0.023360388353466988,
-0.08396915346384048,
-0.04822823777794838,
-0.03550737723708153,
-0.025558801367878914,
-0.08532202243804932,
-0.05533493682742119,
0.1222342923283577,
0.060602303594350815,
0.20869135856628418,
0.12160395085811615,
-0.055151939392089844,
0.002357254270464182,
-0.008873984217643738,
0.022010354325175285,
0.1253904402256012,
0.09815210103988647,
-0.27742162346839905,
0.015452594496309757,
-0.24114318192005157,
-0.028890028595924377,
0.0588865652680397,
-0.08901672065258026,
0.02270529232919216,
-0.11333926767110825,
-0.22614865005016327,
0.09834052622318268,
0.20554174482822418,
0.04198319837450981,
0.13634967803955078,
-0.05051653832197189,
0.032845739275217056,
0.2459924817085266,
0.03608158603310585,
0.031520504504442215,
0.005307062063366175,
-0.01046848762780428,
-0.08965488523244858,
0.0533180870115757,
-0.022832252085208893,
-0.20411212742328644,
0.08712939918041229,
0.06719157844781876,
-0.08477236330509186,
0.06925265491008759,
0.17920684814453125,
-0.124611496925354,
-0.10711833089590073,
0.09173843264579773,
-0.019092652946710587,
-0.09531258046627045,
0.009786279872059822,
-0.21920086443424225,
-0.033831916749477386,
0.09245550632476807,
0.07183722406625748,
-0.029949281364679337,
0.1476406753063202,
-0.22033362090587616,
-0.17829544842243195,
0.0835033655166626,
-0.1098843663930893,
-0.14877153933048248,
-0.03602151945233345,
0.10247309505939484,
-0.14967098832130432,
0.040152087807655334,
0.25343963503837585,
-0.19786007702350616,
-0.1899804025888443,
0.07375195622444153,
0.049676284193992615,
0.0015464070020243526,
0.10486415773630142,
0.13968171179294586,
-0.05847436562180519,
0.24663807451725006,
0.13709139823913574,
0.041742872446775436,
-0.024868933483958244,
-0.02734985575079918,
0.19736631214618683,
0.011597633361816406,
-0.10785404592752457,
-0.16117264330387115,
-0.08082573115825653,
0.08478385955095291,
-0.17869912087917328,
-0.13483355939388275,
-0.294116735458374,
0.010414954274892807,
0.0915435180068016,
0.18182246387004852,
0.08361393213272095,
0.16645099222660065,
-0.003793202806264162,
0.10823143273591995,
-0.07238532602787018,
-0.015210665762424469,
0.1819874346256256,
0.16598577797412872,
-0.012807784602046013,
0.050659745931625366,
-0.12009681016206741,
0.020714007318019867,
0.07490614801645279,
-0.13109420239925385,
-0.22199608385562897,
0.10474269837141037,
-0.05115148797631264,
-0.018240300938487053,
0.18015101552009583,
0.3238178789615631,
0.2828451991081238,
0.2096727043390274,
-0.01666075922548771,
0.09356678277254105,
-0.023474497720599174,
-0.09631724655628204,
-0.004879998043179512,
-0.11690504848957062,
-0.16239511966705322,
-0.14057223498821259,
0.09313409775495529,
-0.046356525272130966,
0.06763198226690292,
0.15673092007637024,
0.26368510723114014,
0.10540494322776794,
-0.08082505315542221,
-0.15710479021072388,
0.25513917207717896,
0.1102118268609047,
0.13349391520023346,
-0.041068825870752335,
0.1790475696325302,
-0.20784339308738708,
0.07634921371936798,
0.006077953148633242,
0.02711847797036171,
0.12770870327949524,
-0.06870543211698532,
-0.12083137780427933,
0.2700709402561188,
0.08746064454317093,
0.2847307324409485,
0.1900789737701416,
0.2069968730211258,
-0.07700731605291367,
0.17003679275512695,
-0.08519095182418823,
-0.19493460655212402,
-0.026130499318242073,
-0.04069877043366432,
0.10118832439184189,
-0.14278897643089294,
0.04257652536034584,
0.06575426459312439,
0.07899251580238342,
0.12473656237125397,
0.003224367741495371,
0.2362343817949295,
-0.0717761293053627,
-0.19828520715236664,
0.12137377262115479,
0.02656858041882515,
-0.13770553469657898,
-0.04458867758512497,
-0.0855010449886322,
0.08470553904771805,
-0.02517417073249817,
-0.008944223634898663,
-0.13255426287651062,
0.12662722170352936,
0.26353365182876587,
-0.2126436084508896,
-0.1939096301794052,
-0.05281109735369682,
0.0637521743774414,
0.21239794790744781,
0.03117729350924492,
-0.12778019905090332,
-0.019750237464904785,
-0.03796110302209854,
-0.08193088322877884,
-0.016038183122873306,
0.047125499695539474,
-0.16704541444778442,
0.14501726627349854,
-0.16475003957748413,
0.06401211023330688,
-0.1693815141916275,
0.09125932306051254,
0.1356845200061798,
-0.014861821196973324,
0.20908375084400177,
-0.08599919080734253,
0.16189247369766235,
0.09330157935619354,
-0.053469572216272354,
-0.009735386818647385,
0.002925292821601033,
0.23379133641719818,
0.03202314302325249,
-0.12760505080223083,
-0.11329954862594604,
0.038007788360118866,
0.09311757981777191,
-0.013852296397089958,
-0.05866613611578941,
0.013072974979877472,
0.21333681046962738,
0.1539856642484665,
0.22255291044712067,
-0.132187619805336,
0.1285567283630371,
-0.15950055420398712,
0.08661377429962158,
0.22023817896842957,
0.3369859755039215,
0.1272326111793518,
-0.15714944899082184,
-0.10185089707374573,
-0.001880574505776167,
-0.047451164573431015,
0.10142852365970612,
0.09847040474414825,
0.3672891855239868,
0.119859978556633,
0.10831142216920853,
-0.33351263403892517,
-0.0458061583340168,
0.06575208157300949,
-0.021664654836058617,
-0.18232835829257965,
0.06325787305831909,
-0.10800286382436752,
-0.20599667727947235,
-0.2124321460723877,
-0.08056404441595078,
-0.1768496185541153,
-0.18648235499858856,
-0.0102548161521554,
0.05752104893326759,
-0.12803100049495697,
-0.005427871830761433,
0.049730509519577026,
-0.03277333080768585,
-0.21528689563274384,
-0.1432066261768341,
0.12162179499864578,
-0.029185429215431213,
-0.0024243409279733896,
-0.0327262282371521,
0.10815445333719254,
-0.16965961456298828,
0.02490062080323696,
0.049506451934576035,
0.0011089297477155924,
-0.0025645974092185497,
-0.08313870429992676,
0.026524703949689865,
0.07928019762039185,
0.03526604175567627,
-0.031254515051841736,
0.052024003118276596,
-0.20436644554138184,
-0.0018497069831937551,
0.12149347364902496,
-0.08515828102827072,
-0.02135147899389267,
-0.23278114199638367,
-0.0887797474861145,
-0.11306662112474442,
0.06654010713100433,
0.055530279874801636,
0.027397122234106064,
-0.017494002357125282,
-0.11615920066833496,
-0.09966692328453064,
-0.06771785020828247,
0.08443760126829147,
-0.3378121852874756,
-0.08474123477935791,
-0.07582995295524597,
-0.1681109219789505,
-0.22708283364772797,
-0.13358187675476074,
0.003963509574532509,
-0.08137165755033493,
-0.12258174270391464,
-0.07174021750688553,
0.21570399403572083,
0.07860878109931946,
0.11977524310350418,
0.017197389155626297,
-0.027586083859205246,
0.14757229387760162,
-0.06049516797065735,
0.21774883568286896,
-0.2113502472639084,
0.023869754746556282,
-0.25568923354148865,
0.22032126784324646,
0.06400904804468155,
0.02082107402384281,
-0.10846816748380661,
-0.1179724633693695,
-0.09100329130887985,
-0.02854817733168602,
0.10202895849943161,
-0.13031105697155,
-0.07006917893886566,
0.03059595823287964,
0.07635315507650375,
0.1127561703324318,
-0.321247398853302,
0.11113860458135605,
0.04867086187005043,
-0.08096157759428024,
-0.1777322143316269,
-0.009217344224452972,
0.014318347908556461,
0.19417811930179596,
0.006009981036186218,
0.10486190021038055,
-0.21051989495754242,
-0.18492476642131805,
-0.20486606657505035,
0.15923555195331573,
-0.040960680693387985,
0.1395299881696701,
-0.2614123225212097,
0.010334729216992855,
0.12336256355047226,
0.12782157957553864,
-0.16528229415416718,
0.03273497894406319,
0.042660653591156006,
0.018332086503505707,
-0.028208144009113312,
-0.12509208917617798,
0.0950867161154747,
-0.08038527518510818,
0.16085825860500336,
-0.05358864739537239,
0.44370168447494507,
0.18034246563911438,
0.03433755785226822,
-0.10379182547330856,
-0.153561070561409,
-0.19701839983463287,
0.12700483202934265,
-0.11130981147289276,
0.2800905406475067,
-0.12656140327453613,
-0.03498147055506706,
0.14146125316619873,
-0.03950843587517738,
0.2519349753856659,
0.13399218022823334,
-0.01565517671406269,
0.07651183754205704,
0.011138948611915112,
-0.032457586377859116,
0.1583135426044464,
-0.003044543555006385,
-0.045738209038972855,
-0.18185129761695862,
0.08322441577911377,
-0.06476130336523056,
-0.2616862952709198,
0.034370094537734985,
-0.09068412333726883,
-0.20453298091888428,
0.035299137234687805,
-0.06408420205116272,
0.056844767183065414,
-0.13576996326446533,
0.132509246468544,
0.2678314447402954,
-0.010692182928323746,
-0.06962908059358597,
0.12967123091220856,
-0.09821046888828278,
-0.0033188792876899242,
-0.05772412195801735,
0.07724321633577347,
0.1668003648519516,
-0.09834979474544525,
-0.19741453230381012,
-0.024487728253006935,
0.07924950122833252,
0.15823578834533691,
-0.04022880643606186,
-0.0323336236178875,
-0.029928239062428474,
0.031470127403736115,
0.09317733347415924,
-0.07594817876815796,
-0.07116208225488663,
-0.0595506988465786,
0.06166204437613487,
-0.22934003174304962,
-0.09273216873407364,
0.26693370938301086,
0.15621452033519745,
-0.012928924523293972,
-0.13969683647155762,
0.11958012729883194,
0.15817676484584808,
0.05220475047826767,
0.10297046601772308,
0.04649755731225014,
0.02348479814827442,
0.08713432401418686,
-0.07467450946569443,
-0.08512170612812042,
-0.0864211916923523,
-0.04215412214398384,
0.10017511993646622,
-0.17315050959587097,
0.14173874258995056,
0.09486093372106552,
0.16182513535022736,
-0.12886759638786316,
-0.2476120889186859,
-0.10416392982006073,
0.10256754606962204,
0.05252964422106743,
0.07774722576141357,
-0.10878210514783859,
-0.2545822858810425,
-0.07739841192960739,
0.23500443994998932,
0.11345770955085754,
0.3353063762187958,
0.058344919234514236,
-0.1550675630569458,
-0.03655851632356644,
-0.11192214488983154,
-0.24286353588104248,
0.13792777061462402,
-0.01531558483839035,
0.12449165433645248,
0.07495182752609253,
-0.13830484449863434,
-0.014856774359941483,
-0.024822788313031197,
-0.08263982832431793,
0.23357240855693817,
0.0923428013920784,
0.10019084811210632,
0.1993352770805359,
0.15648801624774933,
-0.07909811288118362,
-0.030125394463539124,
-0.21403947472572327,
0.027298787608742714,
0.012161657214164734,
0.07273533195257187,
0.12793609499931335,
-0.03226552903652191,
0.024816393852233887,
0.07565905898809433,
-0.19209648668766022,
-0.19889657199382782,
0.08249061554670334,
0.1689588576555252,
-0.07705099880695343,
0.0690169632434845,
-0.026732072234153748,
-0.013155371882021427,
0.022273696959018707,
-0.038117412477731705,
-0.07049459964036942,
0.21122056245803833
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. of which can also be seen in prolidase deficiency. Prolidase deficiency differs from AD-HIES by an increased incidence of neurologic abnormalities, an increased occurrence of viral infections of the skin (e.g., Molluscum contagiosum, warts) and virus-driven malignancies, as well as absence of the non-immunologic findings of AD-HIES (e.g., connective tissue, skeletal and dental involvement) . AR-HIES is caused by biallelic pathogenic variants in K8.ManagementEvaluations Following Initial DiagnosisTo establish the extent of disease and needs in an individual diagnosed with prolidase deficiency, the following evaluations are recommended:Review of systems to assess for the possibility of pulmonary complications. In those with a history of pulmonary complications, consider chest imaging, pulmonary function tests, an echocardiogram to assess for pulmonary hypertension, and consultation with a pulmonologist.Physical examination to evaluate for splenomegaly. If present, perform an abdominal ultrasound examination to | [
-0.073826864361763,
0.11797019839286804,
0.19810529053211212,
-0.20413978397846222,
0.07811540365219116,
0.09133726358413696,
-0.003754245350137353,
-0.04755910113453865,
-0.031532589346170425,
-0.1498102843761444,
0.13870275020599365,
0.040502436459064484,
0.08895243704319,
0.09081745892763138,
-0.12503953278064728,
0.05793464556336403,
0.09818783402442932,
-0.09350286424160004,
-0.08306542783975601,
0.05739781633019447,
-0.03991089016199112,
-0.11098255217075348,
0.4211987853050232,
0.04112985357642174,
0.11393518000841141,
-0.14817720651626587,
0.010964025743305683,
-0.03561084344983101,
0.04989948496222496,
0.13344360888004303,
0.06485921889543533,
0.06562039256095886,
-0.11732286214828491,
-0.10884275287389755,
0.0817972794175148,
-0.03580566123127937,
0.006693896371871233,
-0.032790154218673706,
0.07865597307682037,
-0.14520329236984253,
-0.1907925307750702,
-0.039255302399396896,
-0.0486636720597744,
0.0829620286822319,
0.13751104474067688,
-0.19730539619922638,
0.05050988122820854,
0.012035959400236607,
-0.1946360468864441,
0.0778033658862114,
0.1695725917816162,
-0.07295683026313782,
0.1132124662399292,
-0.18312709033489227,
0.20012767612934113,
0.09195151925086975,
-0.0394272543489933,
0.1664845496416092,
-0.16344282031059265,
0.28098955750465393,
0.015417948365211487,
-0.1136409342288971,
-0.07331962883472443,
-0.2851179242134094,
0.10738546401262283,
0.01854555308818817,
0.053107693791389465,
-0.12466789782047272,
-0.023012863472104073,
-0.04668636620044708,
0.2131595015525818,
0.013664240017533302,
0.21524964272975922,
0.03230246901512146,
-0.11476477980613708,
0.025419514626264572,
0.017825912684202194,
-0.13912054896354675,
-0.013847422786056995,
-0.06599429994821548,
-0.14901714026927948,
0.2220110297203064,
-0.1916436403989792,
0.19645334780216217,
0.095609150826931,
0.3385266661643982,
0.14220167696475983,
0.04372107610106468,
0.155125692486763,
-0.03232420235872269,
0.05156271159648895,
-0.23301063477993011,
0.07190094888210297,
-0.09376919269561768,
-0.14513830840587616,
-0.05975756421685219,
0.033706892281770706,
-0.12102764844894409,
-0.14483335614204407,
0.11978169530630112,
0.020425457507371902,
0.00007528319110861048,
0.017162101343274117,
0.22040094435214996,
0.03685475513339043,
-0.14338499307632446,
-0.1667875051498413,
0.040166743099689484,
-0.2291664183139801,
-0.07277947664260864,
0.22059862315654755,
0.17502611875534058,
-0.16742350161075592,
0.10394327342510223,
-0.03155195713043213,
0.049324072897434235,
0.16039787232875824,
0.020835494622588158,
-0.024199509993195534,
0.022426830604672432,
-0.05897413194179535,
0.11382130533456802,
0.15815302729606628,
-0.09377466887235641,
0.17163100838661194,
0.2013566642999649,
0.035418473184108734,
0.06263745576143265,
0.3023979961872101,
0.09965244680643082,
-0.1694888472557068,
0.030881425365805626,
-0.10694178193807602,
0.07305603474378586,
-0.09121343493461609,
0.06121719628572464,
-0.2786184251308441,
-0.21115893125534058,
0.06514469534158707,
-0.0006275446503423154,
0.04454151913523674,
-0.07922177016735077,
0.11030934751033783,
0.3232954442501068,
-0.1626623570919037,
0.13209626078605652,
0.3391391336917877,
0.04120660200715065,
0.0004951738519594073,
0.07378984987735748,
0.05499260500073433,
-0.07209396362304688,
0.4395527243614197,
-0.06891504675149918,
-0.12625114619731903,
0.15315517783164978,
-0.22287943959236145,
-0.06957510858774185,
-0.3636750280857086,
0.04363158345222473,
0.08291394263505936,
0.019151564687490463,
-0.044748082756996155,
-0.2422381490468979,
0.09141495078802109,
-0.052241045981645584,
-0.0634169951081276,
-0.14996610581874847,
0.16225269436836243,
0.1076512336730957,
-0.05717272683978081,
0.06810173392295837,
0.06788467615842819,
0.04118996113538742,
0.19188562035560608,
-0.0842718705534935,
0.0036560536827892065,
0.022244492545723915,
0.001229535904712975,
-0.109439916908741,
-0.032683830708265305,
-0.08121884614229202,
-0.19820959866046906,
0.007598229683935642,
-0.12728199362754822,
-0.2792474031448364,
0.10765169560909271,
0.10453733801841736,
0.12375038862228394,
-0.013975584879517555,
0.09032033383846283,
0.11944909393787384,
0.011512369848787785,
-0.21449756622314453,
0.1694258749485016,
-0.20405824482440948,
0.1332670897245407,
-0.17303350567817688,
-0.015796169638633728,
-0.06958705186843872,
0.17767348885536194,
-0.34420526027679443,
0.13041333854198456,
-0.05193886160850525,
-0.10495176911354065,
0.025664562359452248,
0.09206657856702805,
0.019691526889801025,
-0.06988413631916046,
0.3300928473472595,
0.08350080251693726,
0.1984868049621582,
-0.0245426744222641,
0.20630164444446564,
-0.07761578261852264,
0.03161943703889847,
-0.23140648007392883,
0.0016252181958407164,
-0.0009940206073224545,
-0.15281203389167786,
0.026408463716506958,
0.0832570493221283,
0.21044059097766876,
-0.27194249629974365,
-0.10561440885066986,
0.052925191819667816,
-0.04491371661424637,
0.013145539909601212,
-0.12303535640239716,
0.06221505254507065,
-0.08966251462697983,
-0.01939881034195423,
0.0841318815946579,
0.14585968852043152,
-0.08089619129896164,
-0.035431310534477234,
0.1009715124964714,
0.12806829810142517,
0.16858506202697754,
-0.01232602633535862,
-0.29147589206695557,
0.035778094083070755,
0.07527724653482437,
0.035568203777074814,
-0.1062699556350708,
0.038010939955711365,
-0.06966051459312439,
0.2090984731912613,
0.09873528778553009,
-0.07243051379919052,
-0.09415319561958313,
0.06370793282985687,
0.146664097905159,
-0.03954704478383064,
-0.4682953953742981,
0.07733196765184402,
0.07168953865766525,
-0.13065065443515778,
0.06861285865306854,
0.012226157821714878,
-0.016605280339717865,
-0.030081624165177345,
0.017952047288417816,
0.14570483565330505,
0.14657437801361084,
-0.010640825144946575,
-0.09028693288564682,
0.029061798006296158,
-0.12326978892087936,
-0.008103464730083942,
0.051581017673015594,
0.21183636784553528,
0.11176878213882446,
0.185129776597023,
-0.2650934159755707,
-0.1158180683851242,
-0.13743136823177338,
0.06981073319911957,
0.26416972279548645,
-0.16046011447906494,
-0.08185692876577377,
-0.05356113240122795,
-0.05898908153176308,
-0.019646551460027695,
0.09412308782339096,
0.1331583857536316,
0.14922232925891876,
-0.016390368342399597,
-0.15687108039855957,
0.1379891335964203,
0.03540491685271263,
0.004948833025991917,
-0.07483436167240143,
-0.11783337593078613,
-0.2134384661912918,
0.013149598613381386,
-0.0049031926319003105,
0.03447557985782623,
-0.04765259101986885,
-0.010404558852314949,
0.18970845639705658,
0.12473303824663162,
-0.03348063677549362,
0.016977883875370026,
-0.11982352286577225,
0.024715527892112732,
0.08174483478069305,
0.06583495438098907,
-0.21721941232681274,
0.05886787176132202,
-0.33452507853507996,
0.022285016253590584,
0.0398128479719162,
-0.1281198263168335,
-0.05650711432099342,
0.01276212465018034,
-0.30136728286743164,
0.14007548987865448,
0.13043053448200226,
0.07906682044267654,
0.1352122724056244,
-0.1640665978193283,
0.14878438413143158,
0.04384242370724678,
-0.06782504916191101,
0.04536966606974602,
-0.09923965483903885,
0.09147549420595169,
0.07319001853466034,
0.026915745809674263,
-0.044268567115068436,
-0.07286260277032852,
0.1855682134628296,
0.15255337953567505,
-0.03729523718357086,
-0.10067132115364075,
0.18333275616168976,
-0.15195530652999878,
-0.113325335085392,
-0.1358492523431778,
0.09349938482046127,
0.013748647645115852,
-0.11321612447500229,
-0.07305358350276947,
-0.022346746176481247,
0.0049601211212575436,
-0.003970526624470949,
-0.05195371061563492,
0.04695376008749008,
-0.14569035172462463,
-0.20675797760486603,
0.05487874522805214,
-0.0030436988454312086,
-0.1916944831609726,
0.09506627172231674,
0.1168031245470047,
-0.12805497646331787,
0.11428432166576385,
0.15537570416927338,
-0.13291291892528534,
-0.2284771353006363,
0.06673624366521835,
0.12275735288858414,
-0.1112111434340477,
0.06372464448213577,
0.1448974609375,
-0.008823329582810402,
0.20403169095516205,
0.11275695264339447,
0.2434503734111786,
0.0615491084754467,
-0.08286841213703156,
0.11971919983625412,
0.02700902707874775,
-0.07022227346897125,
-0.04531494155526161,
-0.16954360902309418,
0.043169111013412476,
0.05392739549279213,
-0.1601511687040329,
-0.08250276744365692,
-0.04456454515457153,
0.09622267633676529,
0.1646655797958374,
0.024139370769262314,
0.06302956491708755,
-0.06113081052899361,
0.050683796405792236,
-0.08374817669391632,
-0.07733146101236343,
0.02121921069920063,
0.24095503985881805,
0.13411998748779297,
-0.0017920827958732843,
-0.05369054898619652,
0.05335201323032379,
-0.0012229048879817128,
-0.06266024708747864,
-0.1036129966378212,
0.07219991087913513,
0.001632177154533565,
0.014992360025644302,
0.1388479471206665,
0.11782081425189972,
0.11248388886451721,
0.0593189038336277,
0.15575604140758514,
0.22429534792900085,
0.11904264986515045,
-0.01576896943151951,
0.10303938388824463,
-0.04764467850327492,
-0.06893474608659744,
-0.03793572634458542,
-0.016246164217591286,
-0.10653693974018097,
-0.011171313934028149,
0.18848377466201782,
0.2541237473487854,
0.15395702421665192,
-0.17713947594165802,
-0.04249180853366852,
0.2648654878139496,
0.04775131493806839,
-0.0249633751809597,
0.021222949028015137,
0.213908851146698,
-0.20974327623844147,
0.10473788529634476,
0.01980506256222725,
0.10835206508636475,
0.11705873906612396,
-0.05436599254608154,
0.13019439578056335,
0.26092633605003357,
0.1134239137172699,
0.255582720041275,
0.02148839831352234,
0.09424646943807602,
0.08182979375123978,
0.06967144459486008,
-0.02844368666410446,
-0.17955733835697174,
0.004558740183711052,
-0.052479326725006104,
0.08049209415912628,
-0.1025051698088646,
-0.022336969152092934,
0.10914591699838638,
0.025320246815681458,
0.11953724175691605,
-0.08335524052381516,
0.16815656423568726,
-0.11439980566501617,
-0.16730321943759918,
0.16281694173812866,
0.02226954512298107,
-0.07829711586236954,
0.015721503645181656,
-0.2244570404291153,
0.09435082972049713,
0.06479193270206451,
0.07304571568965912,
-0.031851474195718765,
0.2228246033191681,
0.14865252375602722,
-0.1350456327199936,
-0.06194893270730972,
0.009430901147425175,
-0.061404332518577576,
0.3774586021900177,
0.007243256084620953,
-0.03751400485634804,
0.07331753522157669,
-0.03524213656783104,
-0.11900487542152405,
0.1111854687333107,
-0.11218233406543732,
-0.18811757862567902,
0.14581085741519928,
-0.08370710909366608,
-0.02347678132355213,
-0.14561596512794495,
0.05239402502775192,
0.11750120669603348,
-0.026996370404958725,
0.03406759351491928,
0.00240720110014081,
0.16578657925128937,
0.16486504673957825,
0.1297956109046936,
-0.034452565014362335,
0.05207665637135506,
0.3756691813468933,
0.05703463405370712,
-0.23717346787452698,
0.0021879763808101416,
-0.01005853246897459,
0.030493296682834625,
0.004204186610877514,
0.03425676003098488,
-0.014322389848530293,
0.023581264540553093,
0.13765329122543335,
0.16865378618240356,
-0.0813198834657669,
0.032817959785461426,
-0.11050060391426086,
0.11159460246562958,
0.15732015669345856,
0.23874244093894958,
0.04197258502244949,
-0.12301885336637497,
-0.05974350869655609,
0.10007752478122711,
-0.1457516849040985,
0.18485932052135468,
0.16303004324436188,
0.12026666104793549,
0.054061226546764374,
0.12104461342096329,
-0.22970452904701233,
-0.08542284369468689,
0.06551538407802582,
0.06621512770652771,
-0.20723611116409302,
-0.07541298121213913,
-0.04619530588388443,
-0.12658661603927612,
-0.22868846356868744,
-0.14026063680648804,
-0.1596313863992691,
-0.2102959305047989,
-0.09460072964429855,
0.0665457621216774,
-0.027305565774440765,
-0.06585098803043365,
-0.022278957068920135,
0.060723625123500824,
-0.14131540060043335,
-0.19033284485340118,
0.03160880506038666,
-0.019818725064396858,
-0.03777902573347092,
-0.1207643672823906,
0.061343248933553696,
-0.2004443258047104,
0.01786174811422825,
0.09772570431232452,
0.07678969949483871,
0.014609801582992077,
0.10171034187078476,
-0.1366369128227234,
0.15401390194892883,
-0.14222730696201324,
0.016685329377651215,
0.0381634347140789,
0.04403386637568474,
-0.18626029789447784,
0.05407698452472687,
-0.026806004345417023,
0.016654791310429573,
-0.1188734695315361,
-0.09569557011127472,
-0.11249895393848419,
0.09430427849292755,
0.0938931405544281,
0.0025656369980424643,
0.02472591958940029,
-0.1327630579471588,
-0.21725152432918549,
-0.20118311047554016,
-0.017426367849111557,
-0.31946831941604614,
-0.11721191555261612,
-0.0065732309594750404,
-0.06856397539377213,
-0.24950291216373444,
0.03485465049743652,
0.12133299559354782,
-0.09736071527004242,
-0.06458931416273117,
-0.032529354095458984,
0.17509940266609192,
0.08386868983507156,
0.23015856742858887,
-0.11473019421100616,
-0.0015449401689693332,
0.17644628882408142,
-0.0761684849858284,
0.0034254032652825117,
-0.1613815426826477,
-0.12709200382232666,
-0.09402785450220108,
0.30535513162612915,
-0.08791597932577133,
0.08260338753461838,
-0.007136642467230558,
-0.2024356573820114,
-0.112532839179039,
-0.15519487857818604,
0.1406981199979782,
-0.048673320561647415,
-0.17173759639263153,
0.09969649463891983,
0.09171753376722336,
0.05788586661219597,
-0.3552488088607788,
-0.03074481338262558,
-0.10135635733604431,
0.026017077267169952,
-0.22120411694049835,
-0.03609875962138176,
-0.01740293763577938,
-0.00828920304775238,
-0.044660016894340515,
0.09945274889469147,
-0.07746677100658417,
0.024382958188652992,
-0.13992126286029816,
0.17653892934322357,
0.07574664056301117,
0.06312453001737595,
-0.29029303789138794,
0.10675708949565887,
0.1697165071964264,
0.20229694247245789,
-0.08915975689888,
-0.07922153919935226,
-0.04987964779138565,
0.03177851438522339,
0.08709776401519775,
-0.14834539592266083,
-0.027352454140782356,
-0.10968811810016632,
-0.028609033674001694,
-0.18555492162704468,
0.32644122838974,
0.12433221936225891,
-0.02999642677605152,
-0.1255594789981842,
0.051483385264873505,
-0.04163508862257004,
0.16231438517570496,
-0.2791103422641754,
0.3305743336677551,
-0.09515745937824249,
-0.020412016659975052,
0.09108784794807434,
0.03287890553474426,
0.20701490342617035,
0.07525341957807541,
-0.08804810047149658,
0.12176966667175293,
-0.08962763100862503,
-0.037381380796432495,
0.0019460446201264858,
0.09974926710128784,
0.12488129734992981,
-0.1408969610929489,
0.10543382167816162,
-0.08381873369216919,
-0.05683542788028717,
0.1649990677833557,
-0.007419487461447716,
-0.1948169469833374,
0.12321268767118454,
-0.020507454872131348,
-0.1637589931488037,
-0.09690206497907639,
0.3537313938140869,
0.14139387011528015,
-0.05338617414236069,
0.06008715555071831,
0.11087354272603989,
-0.10002896934747696,
0.011111042462289333,
-0.051809340715408325,
-0.15753693878650665,
0.029848016798496246,
-0.013946733437478542,
-0.24416927993297577,
0.013852035626769066,
-0.010800882242619991,
0.08698712289333344,
-0.047172289341688156,
-0.07326477766036987,
0.06991511583328247,
0.04437198117375374,
0.10242953151464462,
0.016721930354833603,
-0.1685440093278885,
-0.026347162202000618,
0.1276462823152542,
-0.1403835266828537,
-0.0898318961262703,
0.19451451301574707,
0.08825739473104477,
0.0018646091921254992,
-0.14201657474040985,
0.15998266637325287,
-0.009907661937177181,
0.03923691809177399,
0.15978020429611206,
0.03482067212462425,
0.041469115763902664,
0.07038716226816177,
-0.06979476660490036,
-0.08118631690740585,
-0.001357087166979909,
-0.11486844718456268,
-0.004235135857015848,
-0.150038480758667,
0.1069265827536583,
-0.03515312448143959,
0.21298711001873016,
-0.08984024077653885,
-0.2356988489627838,
-0.0787566527724266,
0.16322699189186096,
-0.060796089470386505,
0.1027834340929985,
-0.12666301429271698,
-0.13750599324703217,
0.06788375228643417,
0.178379625082016,
-0.030556729063391685,
0.10363072901964188,
0.03184543550014496,
-0.13941271603107452,
-0.13134288787841797,
-0.14138031005859375,
-0.2276860624551773,
0.08541274070739746,
0.011012042872607708,
0.027939923107624054,
-0.0267493799328804,
0.024235544726252556,
-0.15695084631443024,
0.02569243498146534,
0.09550309926271439,
0.12439783662557602,
-0.02866598591208458,
-0.004908725153654814,
0.1469726711511612,
0.16627013683319092,
-0.08015051484107971,
-0.06811821460723877,
-0.17015522718429565,
-0.007243363652378321,
0.1326814740896225,
0.08393877744674683,
-0.04637077450752258,
-0.003217292483896017,
-0.0016529860440641642,
0.1319892853498459,
0.03211372345685959,
-0.17239299416542053,
0.031130770221352577,
0.16823287308216095,
-0.10739152133464813,
0.08699797838926315,
-0.08599655330181122,
-0.11561925709247589,
0.01832016557455063,
0.058138247579336166,
-0.16796869039535522,
0.10342544317245483
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. caused by biallelic pathogenic variants in K8.ManagementEvaluations Following Initial DiagnosisTo establish the extent of disease and needs in an individual diagnosed with prolidase deficiency, the following evaluations are recommended:Review of systems to assess for the possibility of pulmonary complications. In those with a history of pulmonary complications, consider chest imaging, pulmonary function tests, an echocardiogram to assess for pulmonary hypertension, and consultation with a pulmonologist.Physical examination to evaluate for splenomegaly. If present, perform an abdominal ultrasound examination to evaluate the extent of splenomegaly.Complete blood count to evaluate for anemia and thrombocytopeniaLiver function tests to assess for the possibility of elevated liver enzymesDevelopmental assessmentConsultation with a wound care specialistConsultation with a clinical geneticist and/or genetic counselorTreatment of ManifestationsNo curative treatment is available.Care is preferably provided by a multidisciplinary team. Supportive treatment of skin, lung, and immunologic manifestations has been efficacious in some (but not in all) | [
-0.04069884866476059,
0.12369035184383392,
0.08623568713665009,
-0.31850647926330566,
0.16853845119476318,
0.1822201907634735,
0.10743916034698486,
-0.027038222178816795,
-0.0689229667186737,
-0.1271815448999405,
0.004173908848315477,
0.19599342346191406,
0.11852268129587173,
0.03822606801986694,
-0.16596218943595886,
0.1210385411977768,
0.16600219905376434,
-0.11010750383138657,
-0.0034930985420942307,
0.1013638824224472,
-0.028871998190879822,
-0.1319372057914734,
0.40420129895210266,
0.03819796070456505,
0.18203245103359222,
-0.1563577950000763,
0.013048052787780762,
-0.07512462884187698,
-0.05140281096100807,
0.06284249573945999,
0.02861781418323517,
-0.046391624957323074,
-0.12529617547988892,
-0.10934404283761978,
0.025828948244452477,
-0.0638788565993309,
-0.0565548911690712,
-0.10468220710754395,
0.10526062548160553,
-0.018865428864955902,
-0.22857175767421722,
-0.08987841755151749,
0.12804624438285828,
-0.022323355078697205,
0.11001256108283997,
-0.28330764174461365,
0.07624118030071259,
-0.011671039275825024,
-0.11230488121509552,
0.11809659004211426,
0.20943936705589294,
-0.1440304070711136,
0.06014317646622658,
-0.17533324658870697,
0.15050412714481354,
0.02112661488354206,
-0.02307755872607231,
0.1207100972533226,
-0.06701624393463135,
0.12069351226091385,
0.12587399780750275,
-0.08610817044973373,
-0.09989327192306519,
-0.2645947337150574,
0.2214965522289276,
-0.07978948205709457,
0.10060886293649673,
-0.18051685392856598,
-0.1653212010860443,
-0.06335045397281647,
0.2359253317117691,
0.03320051357150078,
0.17968566715717316,
0.028186872601509094,
-0.05596136674284935,
0.10424696654081345,
0.055433180183172226,
-0.08996463567018509,
0.09998244792222977,
-0.16528195142745972,
-0.16514649987220764,
0.1890714019536972,
-0.1627493053674698,
0.1436411589384079,
-0.02850939705967903,
0.26117074489593506,
0.14648211002349854,
0.08174600452184677,
0.18169789016246796,
0.02528725564479828,
0.05655559152364731,
-0.2139154076576233,
0.10496509820222855,
-0.022797605022788048,
-0.03958984091877937,
-0.19753259420394897,
0.055243246257305145,
0.02365054562687874,
-0.11258359253406525,
0.07667325437068939,
0.04430375248193741,
0.13938668370246887,
0.03019688092172146,
0.2306751310825348,
0.00421646423637867,
-0.20736458897590637,
-0.1581471860408783,
-0.020204512402415276,
-0.13421468436717987,
-0.08616893738508224,
0.25845015048980713,
0.06677716225385666,
-0.11418356001377106,
-0.00889411848038435,
-0.11945508420467377,
-0.0038290887605398893,
0.10660675913095474,
0.06980650871992111,
-0.16910205781459808,
0.016019046306610107,
-0.03709951043128967,
0.03797740861773491,
0.08314667642116547,
-0.1654551923274994,
0.27414461970329285,
0.13628773391246796,
0.14381884038448334,
0.03577854111790657,
0.20980152487754822,
0.03490551561117172,
-0.06443772464990616,
0.05243441462516785,
-0.08883210271596909,
-0.05050361156463623,
-0.09887108951807022,
-0.029892615973949432,
-0.23220141232013702,
-0.1949564516544342,
-0.02675500139594078,
0.0019502649083733559,
-0.04146059229969978,
-0.0048881033435463905,
0.18148426711559296,
0.2658362090587616,
-0.17267411947250366,
0.05799238383769989,
0.3824334740638733,
0.13124510645866394,
-0.02853279560804367,
0.184195414185524,
0.09047776460647583,
-0.15021032094955444,
0.343252032995224,
0.03121393918991089,
-0.10618244111537933,
0.08341701328754425,
-0.21812520921230316,
0.058805543929338455,
-0.2593519687652588,
0.07023321092128754,
0.17535828053951263,
0.004512081854045391,
0.026531221345067024,
-0.18412630259990692,
0.18354041874408722,
-0.0657760351896286,
-0.07936523109674454,
-0.11331278830766678,
0.1626385897397995,
0.12423316389322281,
-0.08685828745365143,
0.02888297289609909,
0.09395457804203033,
0.0761197879910469,
0.21610480546951294,
0.027153775095939636,
-0.0011155825341120362,
0.06345529854297638,
-0.027185097336769104,
-0.1624995470046997,
-0.021988606080412865,
-0.07123015075922012,
-0.14348164200782776,
0.008137774653732777,
-0.009456856176257133,
-0.2181575894355774,
0.035924531519412994,
0.13363321125507355,
0.08121506869792938,
0.1891382336616516,
0.10062938928604126,
0.1824684590101242,
-0.014997218735516071,
-0.2521319091320038,
0.07598858326673508,
-0.2360633909702301,
0.10542702674865723,
0.012376226484775543,
-0.018461162224411964,
-0.11316115409135818,
0.2346363514661789,
-0.17753244936466217,
0.09726623445749283,
-0.10877086967229843,
-0.0867573469877243,
0.05524342507123947,
0.1320570409297943,
-0.021104220300912857,
-0.07668096572160721,
0.26495712995529175,
0.054318271577358246,
0.08441882580518723,
-0.0520872101187706,
0.2832982540130615,
-0.017410097643733025,
-0.06571727991104126,
-0.1981498748064041,
-0.07538552582263947,
-0.00008150343637680635,
-0.0650293305516243,
0.005747679620981216,
0.02958706021308899,
0.1358325481414795,
-0.20392148196697235,
-0.12880758941173553,
0.026431666687130928,
-0.09854646027088165,
-0.0004886359674856067,
-0.12637409567832947,
-0.03148330748081207,
-0.09085811674594879,
-0.017599185928702354,
0.1310223639011383,
0.16201116144657135,
-0.028615359216928482,
-0.07281315326690674,
0.03390172868967056,
0.3221435248851776,
0.21015402674674988,
-0.048923179507255554,
-0.14118562638759613,
0.06352504342794418,
0.17479421198368073,
-0.06330668926239014,
-0.09460431337356567,
0.09313658624887466,
-0.05813723802566528,
0.145629420876503,
0.012959172017872334,
-0.029977718368172646,
0.026179933920502663,
0.07770958542823792,
0.09224314242601395,
-0.04567916691303253,
-0.38775476813316345,
0.010031239129602909,
0.023094210773706436,
-0.07194268703460693,
0.11704224348068237,
-0.02060735784471035,
-0.04617013409733772,
-0.04130491241812706,
0.16549523174762726,
0.10839300602674484,
0.07560567557811737,
-0.0978277325630188,
-0.051893461495637894,
0.014195227064192295,
-0.06875599175691605,
-0.17688918113708496,
0.03318365290760994,
0.14897507429122925,
0.046091556549072266,
0.12305708974599838,
-0.21099676191806793,
0.020000234246253967,
-0.15952076017856598,
0.0967271625995636,
0.184451624751091,
-0.08578159660100937,
-0.044643666595220566,
-0.014525724574923515,
-0.1614445447921753,
-0.00614274712279439,
0.09458226710557938,
0.08246806263923645,
0.05253336951136589,
0.050106920301914215,
-0.02891375496983528,
0.015631163492798805,
0.0662858709692955,
-0.019640758633613586,
-0.012473402544856071,
-0.06705092638731003,
0.01382681354880333,
0.08556760847568512,
-0.05326728895306587,
0.0555742010474205,
0.0008635013364255428,
0.022234996780753136,
0.16871458292007446,
0.20545777678489685,
-0.0019507133401930332,
-0.04107525199651718,
-0.1629362851381302,
0.04092603549361229,
0.07776905596256256,
0.0963701605796814,
-0.13299009203910828,
0.14134825766086578,
-0.24008721113204956,
-0.026602881029248238,
-0.028919311240315437,
-0.17792931199073792,
-0.007424597628414631,
0.017952678725123405,
-0.19686220586299896,
0.14906461536884308,
0.13676810264587402,
0.020746121183037758,
0.14506888389587402,
-0.11559918522834778,
0.0749114528298378,
0.15688973665237427,
-0.06878397613763809,
0.056800875812768936,
-0.09467847645282745,
0.14123035967350006,
0.09965842217206955,
-0.040695831179618835,
-0.06328973174095154,
0.0014800248900428414,
0.10750684887170792,
0.007781316060572863,
0.10732761025428772,
-0.09471926093101501,
0.29070308804512024,
-0.13530370593070984,
-0.09800925850868225,
-0.10194386541843414,
0.07927066832780838,
0.01843445934355259,
0.006601089145988226,
-0.048214126378297806,
-0.08699464797973633,
-0.002324509434401989,
0.11169777810573578,
-0.04288148880004883,
0.08911971002817154,
-0.08343067765235901,
-0.1419139802455902,
-0.03796440735459328,
-0.002613438991829753,
-0.2450501024723053,
0.15367677807807922,
0.10292905569076538,
-0.04100660979747772,
0.11249423772096634,
0.13988865911960602,
-0.17892761528491974,
-0.16304247081279755,
0.03000332973897457,
0.265207976102829,
-0.15445813536643982,
0.14704196155071259,
0.15565095841884613,
-0.007883233018219471,
0.09625363349914551,
0.12932619452476501,
0.19811135530471802,
0.13375870883464813,
-0.038813550025224686,
0.10579072684049606,
0.12408251315355301,
-0.01938704587519169,
0.023897962644696236,
-0.24123553931713104,
0.16159138083457947,
0.025872593745589256,
-0.0842522531747818,
-0.042941004037857056,
0.09537436813116074,
0.033387329429388046,
0.07349753379821777,
0.04037674516439438,
0.06900061666965485,
-0.0987972691655159,
0.16488489508628845,
-0.045556869357824326,
-0.1803159862756729,
0.03693271800875664,
0.16663499176502228,
0.20041249692440033,
-0.011013871058821678,
-0.06355708092451096,
0.02969738468527794,
-0.04261837154626846,
-0.11026258021593094,
-0.048310503363609314,
0.014603914692997932,
-0.0496721975505352,
0.015788177028298378,
0.2236962914466858,
0.04179786890745163,
0.03657598793506622,
0.03122541680932045,
0.10179508477449417,
0.21536897122859955,
0.19925719499588013,
-0.024895666167140007,
0.14331582188606262,
0.06219930946826935,
-0.07781604677438736,
-0.009745472110807896,
-0.04809168353676796,
-0.035013191401958466,
-0.13716012239456177,
0.1919727325439453,
0.15198856592178345,
0.08097142726182938,
-0.1484169363975525,
-0.06369052082300186,
0.1732090413570404,
-0.04578543081879616,
-0.1352306306362152,
0.0343383364379406,
0.13144703209400177,
-0.10472133755683899,
0.13373738527297974,
0.09482842683792114,
0.1591511070728302,
0.08599809557199478,
-0.10218480229377747,
0.16079415380954742,
0.15465335547924042,
0.05433531105518341,
0.27735140919685364,
0.03648306801915169,
0.1496962308883667,
0.10692767798900604,
0.11927824467420578,
0.026247890666127205,
-0.14632458984851837,
-0.0017071653855964541,
-0.07098916918039322,
0.07164251059293747,
0.0067042275331914425,
0.0852939710021019,
0.15796323120594025,
0.06921342015266418,
0.10571270436048508,
-0.17255264520645142,
0.10747361183166504,
-0.11745026707649231,
-0.12063337862491608,
0.1454685926437378,
0.012651638127863407,
-0.10985249280929565,
-0.04016908258199692,
-0.17670036852359772,
0.018600815907120705,
0.1262882649898529,
0.029829533770680428,
-0.007020811550319195,
0.10832903534173965,
0.10867385566234589,
-0.13229967653751373,
-0.07212691754102707,
0.042688287794589996,
-0.10974451154470444,
0.29276832938194275,
0.07969581335783005,
0.05052288994193077,
0.062082644551992416,
-0.10653658211231232,
-0.14930713176727295,
0.20101028680801392,
-0.026347724720835686,
-0.09264685213565826,
0.19607406854629517,
-0.008246200159192085,
0.01635797880589962,
-0.2020263820886612,
0.08331844955682755,
0.06006486713886261,
0.025473006069660187,
0.07350946217775345,
-0.1064433827996254,
0.09826389700174332,
0.06502311676740646,
0.045119114220142365,
-0.06288684159517288,
0.06261753290891647,
0.2877677083015442,
0.14458304643630981,
-0.24290576577186584,
-0.01784125342965126,
-0.17699474096298218,
0.11056765168905258,
-0.02396191470324993,
0.0851433128118515,
0.012766078114509583,
-0.11739993840456009,
0.22003430128097534,
-0.010830947197973728,
-0.04084638133645058,
0.07855217903852463,
-0.02982814610004425,
0.0023590056225657463,
0.1365555375814438,
0.17070326209068298,
-0.08231208473443985,
-0.07216542959213257,
-0.029928522184491158,
0.03993253782391548,
-0.24417704343795776,
0.16179215908050537,
0.2447013109922409,
0.03090842068195343,
0.05359325930476189,
0.12693575024604797,
-0.11310776323080063,
-0.031129563227295876,
0.09203622490167618,
0.0599328987300396,
-0.17021544277668,
-0.09194552898406982,
0.04248230904340744,
-0.0440804623067379,
-0.25748130679130554,
-0.15351086854934692,
-0.15956157445907593,
-0.1691243201494217,
-0.10720674693584442,
0.09081752598285675,
-0.022071117535233498,
-0.12839071452617645,
-0.01572810672223568,
-0.09251320362091064,
-0.06962063163518906,
-0.18310631811618805,
0.06077907234430313,
-0.012325851246714592,
0.01144763920456171,
-0.1958330124616623,
0.07316843420267105,
-0.05944589152932167,
-0.056028418242931366,
0.025977877900004387,
0.0693129450082779,
0.0007488540722988546,
0.060997124761343,
-0.08842131495475769,
0.0930587500333786,
-0.15350143611431122,
-0.06897202134132385,
0.04031944274902344,
-0.08466082066297531,
-0.23899798095226288,
0.0054686302319169044,
-0.09965049475431442,
-0.062069639563560486,
-0.04562905803322792,
-0.05539536476135254,
-0.17035023868083954,
0.1513988971710205,
-0.011853858828544617,
-0.10931986570358276,
-0.006444379221647978,
-0.11041866987943649,
-0.2112705111503601,
-0.1266818791627884,
0.004720557946711779,
-0.2970479726791382,
-0.128165140748024,
-0.02013486437499523,
-0.08888706564903259,
-0.1977633535861969,
0.024446696043014526,
0.15872980654239655,
-0.07944807410240173,
-0.0678761675953865,
-0.009514285251498222,
0.18211407959461212,
0.07875226438045502,
0.19177593290805817,
-0.14722277224063873,
0.09051284193992615,
0.15574675798416138,
-0.1434399038553238,
0.08233615756034851,
-0.08777202665805817,
-0.1010148748755455,
-0.01683250069618225,
0.21542051434516907,
-0.042982276529073715,
0.0622297003865242,
-0.026193398982286453,
-0.16774523258209229,
-0.11690772324800491,
-0.23798063397407532,
0.10952474921941757,
-0.0504416823387146,
-0.17205782234668732,
0.08473476767539978,
0.013967613689601421,
0.08280190825462341,
-0.19367006421089172,
-0.058496639132499695,
-0.020351704210042953,
0.03902881592512131,
-0.22897490859031677,
0.0503675676882267,
-0.0001350676320726052,
0.1401989758014679,
-0.087335504591465,
0.1216328963637352,
0.0022811663802713156,
0.08919641375541687,
-0.21807076036930084,
0.18991194665431976,
0.12891793251037598,
0.06183977425098419,
-0.21957629919052124,
0.02736426517367363,
0.1381511092185974,
0.10452696681022644,
0.041526783257722855,
0.0006590262055397034,
-0.08373501151800156,
0.02318836748600006,
0.031536001712083817,
0.01017216220498085,
-0.01606469228863716,
-0.12036087363958359,
0.006762557663023472,
-0.14443311095237732,
0.22579625248908997,
0.0056676110252738,
-0.056137342005968094,
-0.07230188697576523,
0.08777951449155807,
0.010070470161736012,
0.08335461467504501,
-0.28240320086479187,
0.22690421342849731,
0.046296436339616776,
-0.031937506049871445,
-0.02127385325729847,
-0.09885059297084808,
0.05588731914758682,
0.09969805181026459,
-0.09958759695291519,
0.06858503073453903,
-0.08655427396297455,
-0.08951031416654587,
0.03798279911279678,
0.045816078782081604,
0.07056030631065369,
-0.09367042779922485,
0.080001100897789,
-0.0011312534334138036,
-0.04162956029176712,
0.2534457743167877,
0.008973859250545502,
-0.09006385505199432,
0.08766589313745499,
0.04077642410993576,
-0.08502338826656342,
-0.0403984934091568,
0.3672856092453003,
0.07899219542741776,
-0.09160993993282318,
0.0633242204785347,
0.06680691242218018,
-0.04102788865566254,
-0.03702773153781891,
-0.09792468696832657,
-0.26721182465553284,
0.05745704099535942,
0.045945197343826294,
-0.23220714926719666,
-0.0827014148235321,
-0.051531363278627396,
0.060834240168333054,
0.013504487462341785,
-0.08822832256555557,
0.07684870064258575,
0.015865834429860115,
0.09095703810453415,
0.002996977651491761,
-0.1945294439792633,
0.0269581601023674,
0.2085406333208084,
-0.14897353947162628,
-0.10849875956773758,
0.1806468367576599,
0.058311838656663895,
-0.019648894667625427,
-0.09212438762187958,
0.11384830623865128,
-0.0612608939409256,
-0.005442359484732151,
0.13770988583564758,
0.03660022094845772,
0.07602949440479279,
0.11326255649328232,
-0.058548253029584885,
-0.11744516342878342,
0.07847971469163895,
-0.0726933628320694,
-0.009244120679795742,
-0.13630375266075134,
0.16439396142959595,
-0.07957962900400162,
0.14863909780979156,
-0.19927410781383514,
-0.041495006531476974,
-0.025424275547266006,
0.2040524184703827,
0.03037906065583229,
0.23385784029960632,
-0.028226707130670547,
-0.15514887869358063,
0.205067440867424,
0.07391267269849777,
-0.1703912764787674,
0.11904270946979523,
0.11896751075983047,
-0.057220786809921265,
-0.17805390059947968,
-0.242341086268425,
-0.24284303188323975,
0.03723549097776413,
-0.07542219012975693,
0.08814141154289246,
-0.0526733435690403,
0.007853860966861248,
-0.04646923020482063,
0.12425307184457779,
0.14206108450889587,
0.18112455308437347,
-0.010223804973065853,
-0.01991434395313263,
0.05615832284092903,
0.13120926916599274,
0.02638707123696804,
-0.17234370112419128,
-0.1370866894721985,
-0.08650418370962143,
0.10053485631942749,
0.0966268852353096,
-0.009958390146493912,
0.021167902275919914,
-0.07319950312376022,
0.0174030102789402,
0.018836263567209244,
-0.2155487835407257,
0.0014985937159508467,
0.0347520112991333,
-0.10020359605550766,
0.026913588866591454,
-0.08038051426410675,
-0.1138521060347557,
0.046939119696617126,
0.008665845729410648,
-0.13498751819133759,
0.008081723004579544
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. perform an abdominal ultrasound examination to evaluate the extent of splenomegaly.Complete blood count to evaluate for anemia and thrombocytopeniaLiver function tests to assess for the possibility of elevated liver enzymesDevelopmental assessmentConsultation with a wound care specialistConsultation with a clinical geneticist and/or genetic counselorTreatment of ManifestationsNo curative treatment is available.Care is preferably provided by a multidisciplinary team. Supportive treatment of skin, lung, and immunologic manifestations has been efficacious in some (but not in all) patients. Caution is warranted in the treatment of infections, which can be fulminant and fatal.Click here (pdf) for further details, including treatments in which only partial or short-term benefit was reported.Prevention of Secondary ComplicationsThose who have undergone splenectomy should be appropriately immunized and treated promptly with antibiotics at the first sign of infection.Antibiotic prophylaxis should also be considered in the appropriate setting.SurveillanceIn the absence of formal surveillance guidelines, the authors recommend:Annual:Skin | [
-0.07610432803630829,
0.109010249376297,
-0.09268473088741302,
-0.29966723918914795,
0.15226778388023376,
0.11050553619861603,
0.06328126788139343,
0.02328784205019474,
-0.10638558864593506,
-0.067140594124794,
0.06711935997009277,
0.2845139503479004,
0.14004632830619812,
0.004510485101491213,
-0.15186026692390442,
0.10536644607782364,
0.10889366269111633,
-0.05322271212935448,
-0.012184332124888897,
0.1578899770975113,
0.06636609137058258,
-0.16139237582683563,
0.3850223124027252,
0.020722532644867897,
0.15254193544387817,
-0.08693930506706238,
-0.002928376430645585,
-0.12451236695051193,
-0.003415237180888653,
0.026750946417450905,
0.06778659671545029,
-0.011887595057487488,
-0.003228863002732396,
-0.23545044660568237,
-0.08675890415906906,
-0.03712862730026245,
-0.09198825806379318,
-0.12665218114852905,
0.13343198597431183,
-0.006687916349619627,
-0.14871113002300262,
-0.16530434787273407,
0.1726776659488678,
0.05187657102942467,
0.088811494410038,
-0.1604047566652298,
0.053311243653297424,
0.03433597832918167,
-0.052043501287698746,
0.11847235262393951,
0.09725925326347351,
-0.11553936451673508,
-0.05052454024553299,
-0.07776155322790146,
0.17160767316818237,
0.06847712397575378,
-0.0378502793610096,
0.08481814712285995,
-0.05516060069203377,
0.07833798974752426,
0.1403147280216217,
-0.07015237212181091,
0.026938900351524353,
-0.2905223071575165,
0.12307333946228027,
0.06538724899291992,
-0.02079274319112301,
-0.2357320338487625,
-0.06604555994272232,
-0.09923281520605087,
0.3870113492012024,
0.091171495616436,
0.09121712297201157,
0.09546810388565063,
-0.06455279141664505,
0.05485085770487785,
0.12055245041847229,
-0.1412651389837265,
0.11420412361621857,
-0.21547259390354156,
-0.2062320113182068,
0.04339231923222542,
-0.13644415140151978,
0.014703700318932533,
-0.07188408821821213,
0.2057686746120453,
0.07974345982074738,
0.08086195588111877,
0.13811610639095306,
0.01743227243423462,
0.03881581500172615,
-0.14568766951560974,
0.03162840008735657,
-0.021970082074403763,
-0.09806785732507706,
-0.2504775822162628,
-0.0011560306884348392,
0.0006417904514819384,
0.04887785762548447,
0.12598460912704468,
0.10352327674627304,
0.13760894536972046,
0.08719738572835922,
0.11710018664598465,
0.09388835728168488,
-0.1731114685535431,
-0.11057170480489731,
-0.009079841896891594,
-0.11157792061567307,
-0.004789858590811491,
0.18538488447666168,
0.08034482598304749,
0.03321472182869911,
-0.05618205666542053,
-0.09548546373844147,
-0.07649481296539307,
0.17741701006889343,
0.10180296003818512,
-0.05973857268691063,
-0.025553492829203606,
-0.07818440347909927,
0.02998567745089531,
0.046728383749723434,
-0.1332625150680542,
0.23223678767681122,
0.07710690051317215,
0.01677505485713482,
-0.051607757806777954,
0.08057373017072678,
0.007495322730392218,
0.026513205841183662,
-0.021905111148953438,
-0.021845711395144463,
-0.2125154286623001,
-0.23204855620861053,
0.0038729917723685503,
-0.20587584376335144,
-0.10396251827478409,
0.040708232671022415,
-0.016961513087153435,
-0.04602951556444168,
0.1296759992837906,
0.20506489276885986,
0.1903182864189148,
-0.08134568482637405,
0.07515224814414978,
0.4072164297103882,
0.12978632748126984,
0.06480191648006439,
0.018353350460529327,
0.021046767011284828,
-0.13031241297721863,
0.2712098956108093,
0.05258826166391373,
-0.12229258567094803,
0.10505647212266922,
-0.15192332863807678,
0.14403307437896729,
-0.30898815393447876,
0.02041071280837059,
0.05475360527634621,
-0.04556834325194359,
0.04837771877646446,
-0.11282747983932495,
0.2065878063440323,
-0.0175287127494812,
-0.05890520662069321,
-0.06270230561494827,
0.00043612730223685503,
-0.04513885825872421,
-0.0788998231291771,
0.045117009431123734,
-0.054064974188804626,
0.06406361609697342,
0.12297629565000534,
0.020918354392051697,
-0.015349154360592365,
0.018628187477588654,
-0.009843231178820133,
-0.057677630335092545,
-0.08682572096586227,
-0.04976743459701538,
-0.0021420889534056187,
0.00863547995686531,
0.001337149878963828,
-0.24857254326343536,
0.013720805756747723,
0.13056866824626923,
0.09752354025840759,
0.1803729385137558,
0.15350311994552612,
0.08562958985567093,
-0.10509252548217773,
-0.1814763993024826,
0.08997282385826111,
-0.18211491405963898,
0.029923124238848686,
0.0625087320804596,
0.006019718945026398,
-0.14760158956050873,
0.13577836751937866,
-0.13904160261154175,
0.09176816791296005,
-0.12744861841201782,
-0.009982769377529621,
-0.00398046663030982,
0.0788915678858757,
0.014913358725607395,
-0.07758527249097824,
0.10517658293247223,
-0.0590394027531147,
0.03627317398786545,
-0.1124555915594101,
0.10630033165216446,
-0.07580723613500595,
0.026598261669278145,
-0.19756624102592468,
-0.10378313809633255,
-0.05856410786509514,
-0.030248655006289482,
-0.11755480617284775,
-0.03223055973649025,
0.0173735860735178,
-0.19527935981750488,
-0.144539475440979,
0.02676982991397381,
-0.060967717319726944,
0.023641029372811317,
-0.0537882074713707,
-0.037827227264642715,
-0.10079678893089294,
0.08333420753479004,
0.07802353799343109,
0.1558825522661209,
-0.09095893055200577,
-0.07938118278980255,
-0.026751048862934113,
0.25380373001098633,
0.12642934918403625,
-0.07730219513177872,
-0.006036901846528053,
0.11523594707250595,
0.1940397471189499,
-0.18856167793273926,
-0.07706098258495331,
0.13221347332000732,
-0.023251283913850784,
0.09319456666707993,
0.0065853470005095005,
-0.059233713895082474,
-0.05122283473610878,
0.061522677540779114,
0.1289154291152954,
-0.05466846004128456,
-0.3227292001247406,
0.05733555927872658,
0.12420130521059036,
0.031783610582351685,
0.11815496534109116,
-0.07720895111560822,
-0.04620416834950447,
-0.08389248698949814,
0.17757238447666168,
0.01143952552229166,
0.05629580840468407,
0.027550192549824715,
-0.07979261130094528,
0.09377965331077576,
-0.03410015255212784,
-0.1971515715122223,
-0.07366841286420822,
0.10565658658742905,
0.029535958543419838,
0.11252301186323166,
-0.07636453211307526,
-0.0252531711012125,
-0.25667816400527954,
0.10288495570421219,
0.2470732033252716,
-0.06290053576231003,
0.1313520073890686,
0.07661721110343933,
-0.04324307292699814,
0.01758364774286747,
0.09734237194061279,
-0.01645914651453495,
0.09693565219640732,
0.1229032576084137,
0.0794871374964714,
0.07143799960613251,
0.13911636173725128,
0.1159931942820549,
-0.004334894474595785,
-0.004244518466293812,
0.11553679406642914,
0.1517394483089447,
-0.17839132249355316,
0.09623102098703384,
0.10899379849433899,
-0.04901307821273804,
0.0343550443649292,
0.14996656775474548,
-0.1275724619626999,
-0.0787205919623375,
-0.14662368595600128,
-0.10622440278530121,
0.048370111733675,
0.06310420483350754,
-0.008010633289813995,
0.2790069282054901,
-0.07127728313207626,
-0.03720991313457489,
-0.08696377277374268,
-0.1327516734600067,
0.07754732668399811,
0.015455622225999832,
-0.23127859830856323,
0.16050077974796295,
0.09102734923362732,
-0.06804129481315613,
0.21102072298526764,
-0.22067171335220337,
0.0751299262046814,
0.23695532977581024,
-0.10948542505502701,
0.04597831889986992,
-0.11247798800468445,
0.08138071745634079,
0.0849049910902977,
0.014438093639910221,
-0.03174343332648277,
-0.040283214300870895,
0.12191097438335419,
-0.06598538160324097,
0.05660255253314972,
-0.03605177253484726,
0.267514705657959,
-0.15098582208156586,
-0.08306477963924408,
-0.07792013883590698,
-0.020296890288591385,
-0.022960178554058075,
0.11249063909053802,
-0.1655815839767456,
-0.17522071301937103,
-0.08834995329380035,
0.08178703486919403,
-0.08923376351594925,
0.20206935703754425,
0.050712693482637405,
-0.10939866304397583,
-0.07239048182964325,
-0.025609495118260384,
-0.23523280024528503,
0.15824000537395477,
0.10700225085020065,
0.04190091788768768,
0.014703337103128433,
0.1620655655860901,
-0.17256176471710205,
-0.15471039712429047,
0.07756458222866058,
0.26463255286216736,
-0.14729046821594238,
0.2511371076107025,
0.09591532498598099,
-0.03224810212850571,
0.011158987879753113,
0.07372695952653885,
0.07287485152482986,
0.04822276905179024,
0.006816132925450802,
0.10716806352138519,
0.10447078198194504,
-0.03252595290541649,
0.030935829505324364,
-0.12392584979534149,
0.18141894042491913,
-0.16368748247623444,
-0.07707297801971436,
-0.007468544878065586,
0.015466880053281784,
0.10523828119039536,
0.06581416726112366,
-0.005414002109318972,
0.045438189059495926,
-0.11760497093200684,
0.11829300969839096,
-0.06447713822126389,
-0.11974527686834335,
0.10383840650320053,
0.18790526688098907,
0.12840016186237335,
0.07802298665046692,
-0.057178765535354614,
0.04845033213496208,
0.0048356070183217525,
-0.07028335332870483,
-0.004118146374821663,
0.006711568683385849,
-0.04416700080037117,
-0.11821666359901428,
0.2016911804676056,
0.043145451694726944,
-0.05002898350358009,
-0.04475313425064087,
0.0440346822142601,
0.131325364112854,
0.061999592930078506,
-0.05932895094156265,
0.19693848490715027,
-0.010358700528740883,
-0.0406535305082798,
-0.02843192219734192,
0.08663175255060196,
0.01703394204378128,
-0.21188871562480927,
0.07245787233114243,
0.17553363740444183,
-0.04601908475160599,
-0.08085176348686218,
-0.13415832817554474,
0.11881361156702042,
-0.04940936341881752,
-0.12993304431438446,
0.07762996107339859,
0.0654052272439003,
0.039809297770261765,
0.08402199298143387,
0.20190773904323578,
0.31317567825317383,
0.15733176469802856,
-0.02119205705821514,
0.09075391292572021,
0.16029147803783417,
-0.004849521443247795,
0.08163704723119736,
0.018725106492638588,
0.23600201308727264,
0.038338419049978256,
0.09610964357852936,
0.06674166768789291,
-0.1499345600605011,
0.022246530279517174,
-0.025830473750829697,
0.047387897968292236,
-0.0368889644742012,
0.119255430996418,
0.1392410844564438,
-0.012382975779473782,
0.0679575651884079,
-0.07447917014360428,
0.06218956038355827,
-0.08233485370874405,
-0.11573628336191177,
0.06745074689388275,
-0.056671082973480225,
-0.10806020349264145,
-0.059791199862957,
-0.1217106506228447,
-0.05880322307348251,
0.16153186559677124,
-0.041585929691791534,
0.08267108350992203,
-0.02101636491715908,
0.0404854379594326,
-0.17603804171085358,
0.019412146881222725,
0.0625089704990387,
-0.0997835099697113,
0.05438348278403282,
0.078178770840168,
0.03197110444307327,
0.027164401486516,
-0.14165562391281128,
-0.18366406857967377,
0.12774094939231873,
0.13701917231082916,
-0.04661513492465019,
0.1994132101535797,
0.00919465720653534,
-0.09943556040525436,
-0.14491456747055054,
0.012073850259184837,
0.0025070805568248034,
-0.06343936920166016,
0.06614739447832108,
-0.1618845909833908,
0.054141752421855927,
-0.03309527412056923,
0.002065689768642187,
-0.006272844970226288,
-0.016383826732635498,
0.2453092634677887,
0.15471145510673523,
-0.13509942591190338,
-0.03011789172887802,
-0.27891233563423157,
0.11743734776973724,
-0.044519148766994476,
0.08387663215398788,
0.027587255463004112,
0.03428133949637413,
0.20735913515090942,
-0.03715994954109192,
0.06591887027025223,
0.11248341202735901,
0.09845167398452759,
0.008430873043835163,
0.0946035087108612,
0.14183641970157623,
-0.017810989171266556,
-0.15950150787830353,
0.02163417637348175,
-0.08799933642148972,
-0.19550225138664246,
0.12064844369888306,
0.14743991196155548,
0.00007041273056529462,
-0.06827206909656525,
0.25596049427986145,
0.020425666123628616,
-0.013853718526661396,
0.15658138692378998,
0.03514323756098747,
-0.05237683281302452,
-0.04029484838247299,
0.0001420282496837899,
-0.15503525733947754,
-0.3319450616836548,
-0.15698236227035522,
-0.20103414356708527,
-0.10326247662305832,
-0.04019125923514366,
0.07939586788415909,
0.0568225271999836,
-0.12565061450004578,
0.03523821756243706,
-0.2327236831188202,
-0.01123043242841959,
-0.12471041828393936,
0.09569350630044937,
0.008207151666283607,
0.0969269871711731,
-0.17517217993736267,
0.23337115347385406,
-0.045272063463926315,
-0.08920802175998688,
0.012479519471526146,
0.024065667763352394,
-0.038772691041231155,
0.0656634122133255,
-0.06614608317613602,
0.12758728861808777,
-0.021692775189876556,
-0.15612371265888214,
0.017898237332701683,
-0.051645778119564056,
-0.23404312133789062,
0.09282437711954117,
-0.09351411461830139,
-0.12712837755680084,
-0.09641037881374359,
-0.06311170011758804,
-0.09030718356370926,
0.07269025593996048,
-0.01217004656791687,
-0.19851411879062653,
0.10723338276147842,
-0.1092173382639885,
-0.1451747715473175,
-0.11357594281435013,
-0.051833510398864746,
-0.25580596923828125,
-0.09598172456026077,
-0.05242070183157921,
0.03575449436903,
-0.1508912742137909,
-0.07614041119813919,
0.1437138170003891,
-0.17111046612262726,
-0.08455798029899597,
-0.03515190631151199,
0.12735889852046967,
0.01875643990933895,
0.11145053058862686,
-0.10834499448537827,
0.05881974846124649,
0.06740305572748184,
-0.03856181725859642,
0.061248600482940674,
-0.12917792797088623,
-0.159910649061203,
-0.1468018740415573,
0.21076293289661407,
0.02341960184276104,
0.02572820335626602,
-0.1385798305273056,
-0.1278168261051178,
-0.14436060190200806,
-0.33103400468826294,
0.16426658630371094,
0.015687566250562668,
-0.10213593393564224,
-0.05236612632870674,
0.0034038934390991926,
0.05171844735741615,
-0.20824909210205078,
-0.019222578033804893,
0.03299994394183159,
0.10920210182666779,
-0.15228354930877686,
0.10146179050207138,
0.020239951089024544,
0.22699382901191711,
0.001544875092804432,
0.0220695398747921,
-0.1990525722503662,
0.006564761511981487,
-0.21512755751609802,
0.1964016556739807,
0.0398973748087883,
0.03145238757133484,
-0.0597912073135376,
0.013472629711031914,
0.0715973824262619,
0.04704360291361809,
0.11104942858219147,
-0.10395923256874084,
-0.06771695613861084,
-0.03363620117306709,
0.06615138798952103,
-0.02050335332751274,
0.012805746868252754,
-0.1042986512184143,
-0.0568104088306427,
-0.1072087287902832,
0.21674400568008423,
-0.08407070487737656,
-0.02050047554075718,
-0.030928058549761772,
0.07801351696252823,
-0.020146554335951805,
0.07838519662618637,
-0.14270003139972687,
0.16218075156211853,
0.05753267928957939,
-0.08396928757429123,
0.052899185568094254,
-0.0790858343243599,
0.10433585196733475,
0.11826413869857788,
0.03539440408349037,
0.028961261734366417,
-0.10545370727777481,
-0.052272167056798935,
0.0720812976360321,
-0.029675524681806564,
0.04436371475458145,
-0.23084886372089386,
0.03717521205544472,
0.015843110159039497,
-0.10342153906822205,
0.18129278719425201,
0.022369151934981346,
0.06917978823184967,
0.033368661999702454,
-0.0018155376892536879,
-0.003167589195072651,
-0.01791113242506981,
0.20191381871700287,
0.10708072036504745,
-0.06803105771541595,
0.06659432500600815,
0.012528447434306145,
0.025754284113645554,
-0.05830121412873268,
0.04214515537023544,
-0.24231970310211182,
0.0873565524816513,
0.04582144692540169,
-0.22737140953540802,
-0.13545723259449005,
-0.10463967174291611,
0.16304391622543335,
0.02817819081246853,
-0.05116856470704079,
-0.007018555887043476,
0.12221969664096832,
0.05427205562591553,
-0.044080011546611786,
-0.13597607612609863,
0.02854921668767929,
0.22863894701004028,
-0.08442653715610504,
-0.04584987461566925,
0.07715587317943573,
0.10732156783342361,
-0.06650658696889877,
-0.07790683954954147,
0.1294352412223816,
-0.10860778391361237,
-0.013100720010697842,
0.12112318724393845,
0.062226537615060806,
-0.055121198296546936,
0.2138165533542633,
-0.03799831122159958,
0.005263321567326784,
0.03946659341454506,
-0.16601569950580597,
-0.11263208091259003,
-0.08805537223815918,
0.0762682780623436,
-0.10504163056612015,
0.04549505561590195,
-0.12137369066476822,
0.08719918876886368,
0.07247864454984665,
0.16093167662620544,
0.06636996567249298,
0.17902760207653046,
-0.06425751000642776,
-0.10531780868768692,
0.07992158085107803,
-0.011818120256066322,
-0.15589340031147003,
0.07753165811300278,
0.1046304926276207,
-0.030685611069202423,
-0.278417706489563,
-0.2717105448246002,
-0.1820090413093567,
0.020651504397392273,
-0.13307268917560577,
0.08810143172740936,
-0.006421669386327267,
-0.0571756437420845,
0.007152263540774584,
0.2367490977048874,
0.1522277593612671,
0.14475883543491364,
0.07841167598962784,
0.006169044878333807,
0.13739646971225739,
0.13049334287643433,
0.0402897410094738,
-0.09379434585571289,
-0.15636888146400452,
-0.1791352778673172,
0.0659126341342926,
0.04811277240514755,
-0.038345929235219955,
0.1146291121840477,
-0.1816404014825821,
0.05977862328290939,
-0.04758149012923241,
-0.19749660789966583,
0.05517297238111496,
0.06889338046312332,
-0.046483010053634644,
-0.018548065796494484,
-0.06548084318637848,
-0.028528431430459023,
0.09088311344385147,
0.023488657549023628,
-0.0864364355802536,
-0.010791409760713577
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. (but not in all) patients. Caution is warranted in the treatment of infections, which can be fulminant and fatal.Click here (pdf) for further details, including treatments in which only partial or short-term benefit was reported.Prevention of Secondary ComplicationsThose who have undergone splenectomy should be appropriately immunized and treated promptly with antibiotics at the first sign of infection.Antibiotic prophylaxis should also be considered in the appropriate setting.SurveillanceIn the absence of formal surveillance guidelines, the authors recommend:Annual:Skin examination for evidence of malignant transformation in persons with chronic recalcitrant skin ulcersComplete blood countLiver function testsAbdominal ultrasound examination to assess liver and spleen sizeFollow up as recommended by a pulmonologist and immunologist;Follow-up assessments of motor and cognitive development as recommended for educational planning.Agents/Circumstances to AvoidIndividuals with prolidase deficiency who have splenomegaly should avoid contact sports given the increased risk for splenic rupture.Evaluation of Relatives at RiskSee Genetic | [
-0.034082647413015366,
0.16564926505088806,
-0.17238323390483856,
-0.3569170832633972,
0.09479208290576935,
0.03856854513287544,
-0.01634933054447174,
-0.08282976597547531,
-0.13675592839717865,
-0.12375566363334656,
0.2862812280654907,
0.08892650157213211,
0.11761069297790527,
0.044478096067905426,
-0.25528183579444885,
0.16532181203365326,
-0.006562928669154644,
-0.02684091590344906,
-0.06477625668048859,
0.15319661796092987,
0.10920527577400208,
-0.18940423429012299,
0.3947661221027374,
0.08019007742404938,
0.16700203716754913,
-0.03631044551730156,
0.04922610893845558,
-0.02207377925515175,
-0.11548135429620743,
-0.004277196247130632,
0.12617462873458862,
0.00594960805028677,
0.09153886139392853,
-0.2070934921503067,
0.017010191455483437,
0.04258251562714577,
-0.22418759763240814,
-0.13368076086044312,
0.21438831090927124,
-0.05986274033784866,
-0.12481369078159332,
-0.16330185532569885,
0.08449254184961319,
0.10524188727140427,
0.10165628045797348,
-0.23313811421394348,
0.10347210615873337,
0.10775268822908401,
-0.16306371986865997,
0.14991505444049835,
0.09527958184480667,
-0.13203537464141846,
0.03963570296764374,
-0.06824024766683578,
0.20849120616912842,
0.045561905950307846,
-0.08676569163799286,
0.14231649041175842,
-0.11075257509946823,
0.07659237831830978,
0.16808108985424042,
-0.2210499793291092,
0.03361591324210167,
-0.3426278531551361,
0.2966863811016083,
0.1960054636001587,
-0.005307481624186039,
-0.19402039051055908,
-0.027028679847717285,
-0.10888193547725677,
0.43721216917037964,
0.08853968232870102,
0.07390310615301132,
0.029224250465631485,
-0.014780004508793354,
-0.017786845564842224,
0.058305904269218445,
-0.09755593538284302,
0.05209733545780182,
-0.3331354558467865,
-0.2339577078819275,
0.021863333880901337,
-0.1267503947019577,
0.08696989715099335,
-0.05534786731004715,
0.12470301985740662,
0.011649851687252522,
0.13102024793624878,
0.02384444884955883,
-0.012327484786510468,
0.03393955156207085,
-0.08167358487844467,
-0.04056404531002045,
0.11013153195381165,
-0.09584125131368637,
-0.2394811511039734,
-0.1590327024459839,
0.026363233104348183,
0.057766206562519073,
0.21235835552215576,
0.1099722608923912,
-0.02978694997727871,
0.03295163810253143,
0.1574985235929489,
0.015869421884417534,
-0.10502032935619354,
-0.1870422661304474,
-0.04693777859210968,
-0.057154059410095215,
0.06370177119970322,
0.2055986076593399,
0.06900360435247421,
-0.029898198321461678,
0.013493502512574196,
-0.15576814115047455,
-0.0254549290984869,
0.14756342768669128,
0.04096883535385132,
0.02029649168252945,
-0.12382011860609055,
-0.06256327778100967,
0.024143323302268982,
0.12370418012142181,
-0.06282144784927368,
0.19742457568645477,
0.07161609083414078,
0.056468382477760315,
-0.09693213552236557,
0.15012383460998535,
-0.04445785656571388,
-0.02770608849823475,
-0.0806201621890068,
-0.11818382889032364,
-0.18033239245414734,
-0.16699260473251343,
-0.05085254833102226,
-0.2120562195777893,
-0.06874299794435501,
0.04910675436258316,
-0.05240284278988838,
0.04846533387899399,
0.08643767982721329,
0.26223281025886536,
0.3440697491168976,
-0.19357620179653168,
0.16016361117362976,
0.3503996729850769,
0.11666198819875717,
0.0011226293863728642,
-0.14110319316387177,
0.0915851965546608,
-0.13676045835018158,
0.2783752977848053,
-0.08279655873775482,
-0.1518540382385254,
0.07931861281394958,
-0.14767241477966309,
0.06998267024755478,
-0.20228463411331177,
-0.09371518343687057,
0.03110373392701149,
-0.019663982093334198,
0.16772615909576416,
-0.15140384435653687,
0.15488070249557495,
0.1955258548259735,
0.01966177485883236,
-0.07777106016874313,
0.07670268416404724,
-0.06582855433225632,
-0.02313121221959591,
-0.04483545199036598,
0.04637977480888367,
-0.024688715115189552,
0.06115183234214783,
0.036124445497989655,
0.011691770516335964,
-0.024566954001784325,
0.05438636988401413,
-0.005666947923600674,
-0.028069835156202316,
0.052762411534786224,
0.06088711693882942,
0.0023272440303117037,
0.033383965492248535,
-0.29057377576828003,
-0.0386812761425972,
0.22548484802246094,
0.046079058200120926,
0.12488827854394913,
0.08944735676050186,
0.05802612006664276,
-0.07053060084581375,
-0.2138223648071289,
0.13400927186012268,
-0.1212083101272583,
0.011687166057527065,
-0.06476566195487976,
0.041323158890008926,
-0.0021471690852195024,
0.015539168380200863,
-0.12935444712638855,
0.14138950407505035,
-0.10235127806663513,
-0.053185347467660904,
-0.02791421301662922,
0.005166429560631514,
0.12952782213687897,
-0.04932659491896629,
0.12858699262142181,
-0.13755324482917786,
0.04868776723742485,
-0.08302107453346252,
0.22873732447624207,
-0.04382556676864624,
0.04266384243965149,
-0.2210802435874939,
-0.04870748147368431,
-0.0634775310754776,
-0.12488570809364319,
-0.125290185213089,
0.06554079800844193,
0.017730405554175377,
-0.2706568241119385,
-0.14188498258590698,
-0.077788807451725,
-0.00790445413440466,
-0.05687721446156502,
-0.04159248247742653,
0.007043471094220877,
-0.13389302790164948,
0.21381664276123047,
-0.000771647784858942,
0.06246854364871979,
-0.1245889887213707,
-0.06166918948292732,
-0.010227110236883163,
0.33815398812294006,
0.03417413309216499,
-0.050644367933273315,
-0.06067580729722977,
0.19252455234527588,
0.13254602253437042,
-0.16328167915344238,
-0.1422717422246933,
0.10313470661640167,
0.05758509039878845,
0.11587785184383392,
-0.03466244786977768,
-0.14603744447231293,
-0.08755423128604889,
0.035366520285606384,
-0.00994101446121931,
-0.016004061326384544,
-0.3890424966812134,
-0.01195212360471487,
0.06411261111497879,
-0.004799888469278812,
0.18791039288043976,
-0.1571558266878128,
-0.02165757492184639,
-0.09429994970560074,
0.06623446196317673,
0.012909344397485256,
0.01506961602717638,
-0.034090556204319,
-0.0914231613278389,
0.08200336247682571,
-0.03512288257479668,
-0.14010031521320343,
-0.1275695413351059,
0.10580744594335556,
0.02154017984867096,
0.12679515779018402,
-0.15868249535560608,
-0.07262367755174637,
-0.2540728449821472,
-0.04388764873147011,
0.381493479013443,
-0.011084651574492455,
0.18440048396587372,
-0.00048203530604951084,
0.0003573996073100716,
-0.004954361356794834,
0.11323513090610504,
-0.02246640808880329,
0.06643709540367126,
0.11868041753768921,
0.10609018802642822,
0.07878615707159042,
0.16188473999500275,
0.13799329102039337,
-0.07594458013772964,
0.03480355814099312,
-0.004219451453536749,
-0.005211045499891043,
-0.19057470560073853,
0.04117773845791817,
0.012158175930380821,
0.007035131100565195,
0.08215229958295822,
0.18218395113945007,
-0.19977885484695435,
-0.08179327845573425,
-0.013423576951026917,
-0.12198831140995026,
0.07933137565851212,
0.10012064129114151,
-0.05967434123158455,
0.2512260377407074,
-0.1292000561952591,
0.01809706911444664,
-0.1008097305893898,
-0.016312867403030396,
-0.11094246059656143,
-0.03568929061293602,
-0.19315548241138458,
0.05111416429281235,
0.020786330103874207,
-0.023753603920340538,
0.1643485426902771,
-0.10492359101772308,
0.0698317363858223,
0.14539580047130585,
0.07268299162387848,
0.0314076729118824,
0.01275963056832552,
0.046605922281742096,
0.05156055465340614,
0.009702778421342373,
-0.010150154121220112,
-0.018508614972233772,
-0.022102847695350647,
0.023174729198217392,
0.04616271331906319,
-0.002467855578288436,
0.28309863805770874,
-0.08315308392047882,
-0.11986405402421951,
-0.16458643972873688,
0.029993735253810883,
-0.061820849776268005,
0.16774491965770721,
-0.2392616719007492,
-0.2459973841905594,
-0.02737782523036003,
0.07888458669185638,
-0.035884659737348557,
0.11437325924634933,
0.01844744384288788,
-0.09269057214260101,
-0.17535445094108582,
0.03706011176109314,
-0.14550243318080902,
0.21875852346420288,
0.18460354208946228,
-0.0021440039854496717,
0.011209395714104176,
0.21069523692131042,
-0.203886941075325,
-0.19237865507602692,
0.11988861113786697,
0.24199888110160828,
-0.15626531839370728,
0.25088566541671753,
0.1682950258255005,
0.01098942942917347,
0.10572244226932526,
0.0632687658071518,
0.12183400243520737,
0.06184199079871178,
0.08218923956155777,
0.20686666667461395,
0.017743119969964027,
-0.08386828005313873,
-0.010364081710577011,
-0.19554927945137024,
0.2353333979845047,
-0.2432371973991394,
-0.1581050455570221,
-0.07642392069101334,
0.01747465878725052,
0.1270638406276703,
0.07650049030780792,
-0.003131299978122115,
-0.0006962031475268304,
-0.2391655445098877,
0.12554003298282623,
-0.11805028468370438,
-0.25428083539009094,
0.10111048817634583,
0.22728149592876434,
0.06610728055238724,
0.11663868278265,
-0.09958156198263168,
0.06273636221885681,
0.04368075355887413,
-0.09131733328104019,
-0.10723293572664261,
0.057875752449035645,
0.024741383269429207,
-0.13532768189907074,
0.22195611894130707,
0.08626767992973328,
0.04303295537829399,
-0.022330058738589287,
-0.08293799310922623,
0.1052757129073143,
-0.09615658968687057,
0.019376711919903755,
0.08917466551065445,
-0.03532719612121582,
0.0979975014925003,
-0.14009873569011688,
-0.006078265141695738,
-0.085995152592659,
-0.14576946198940277,
0.082656130194664,
0.3088908791542053,
-0.08245907723903656,
-0.12019778788089752,
-0.13361778855323792,
0.17169703543186188,
-0.1652395874261856,
-0.1504935473203659,
0.10856898128986359,
0.024710388854146004,
0.08945270627737045,
0.03745599463582039,
0.14510753750801086,
0.31150418519973755,
0.14243961870670319,
-0.008071434684097767,
0.02995241992175579,
0.23674605786800385,
-0.0396612323820591,
0.08403134346008301,
0.10116323828697205,
0.19736669957637787,
0.019360555335879326,
0.09145346283912659,
0.13171865046024323,
-0.1380585879087448,
0.10553434491157532,
-0.05353295058012009,
0.07594215869903564,
-0.037765342742204666,
0.07216637581586838,
0.052904848009347916,
-0.1296251267194748,
-0.03370366245508194,
-0.01569618098437786,
0.11833202838897705,
-0.05322927609086037,
-0.046348936855793,
0.09057524055242538,
-0.08344023674726486,
-0.024165598675608635,
0.027782749384641647,
-0.06447192281484604,
-0.1611897200345993,
-0.0408211313188076,
0.09204046428203583,
0.03251698985695839,
0.05083717778325081,
0.19718889892101288,
-0.24819736182689667,
-0.01639382541179657,
0.009520623832941055,
-0.030934881418943405,
0.1470378041267395,
-0.03641365468502045,
0.04498105123639107,
0.08774062246084213,
-0.19084225594997406,
-0.13742347061634064,
0.09035471826791763,
0.08861251920461655,
-0.06922914832830429,
0.13302330672740936,
-0.04225774481892586,
0.06873749941587448,
-0.1770341396331787,
0.030850093811750412,
0.02899007312953472,
-0.045686591416597366,
0.09260519593954086,
-0.04954744875431061,
0.20505179464817047,
-0.041141923516988754,
0.11694134026765823,
-0.0758621022105217,
0.06836774200201035,
0.2522510290145874,
0.09154213219881058,
-0.11976949870586395,
-0.07407576590776443,
-0.19080054759979248,
0.08517969399690628,
-0.19807398319244385,
0.052657805383205414,
0.05295282229781151,
0.005636939778923988,
0.19766458868980408,
0.008479492738842964,
0.11650597304105759,
-0.025542140007019043,
0.08135263621807098,
-0.007083929609507322,
0.16911812126636505,
0.1912401169538498,
0.039022378623485565,
-0.048272550106048584,
-0.08431071788072586,
-0.01385916955769062,
-0.12561050057411194,
0.12421112507581711,
0.1279689371585846,
0.061696939170360565,
-0.09280338883399963,
0.19488918781280518,
0.10970456153154373,
0.042410943657159805,
0.14061179757118225,
-0.08633890748023987,
-0.06030897796154022,
-0.09658540040254593,
0.0888519287109375,
-0.14028038084506989,
-0.33286935091018677,
-0.07283767312765121,
-0.24995584785938263,
-0.08399185538291931,
-0.05959274247288704,
0.07041990011930466,
0.07846805453300476,
-0.10715153068304062,
0.04150276631116867,
-0.1847875714302063,
-0.10536004602909088,
-0.05533302575349808,
0.1057921051979065,
0.056375253945589066,
0.05365980044007301,
-0.25804346799850464,
0.11160805076360703,
-0.09555617719888687,
-0.09077628701925278,
-0.001594028202816844,
-0.020909231156110764,
0.03809273988008499,
0.15262319147586823,
0.0011977310059592128,
0.0015334398485720158,
-0.05163753777742386,
-0.0904497504234314,
0.06500416994094849,
-0.11840686202049255,
-0.15765628218650818,
0.030948173254728317,
-0.14712728559970856,
-0.20827922224998474,
-0.09121768176555634,
-0.031802110373973846,
-0.01503776852041483,
0.05907284840941429,
-0.018324168398976326,
-0.18288037180900574,
0.04775198921561241,
-0.1550951600074768,
-0.18770849704742432,
-0.08305592089891434,
0.04209161922335625,
-0.2431693822145462,
-0.06852686405181885,
-0.027150021865963936,
-0.1615406721830368,
-0.19528965651988983,
-0.12983492016792297,
0.08262521028518677,
-0.10080064088106155,
-0.1954328864812851,
-0.04004526510834694,
0.006143446546047926,
-0.04014398530125618,
0.15719345211982727,
-0.0435529388487339,
0.06190440058708191,
0.0942419245839119,
0.1367597132921219,
0.0016861706972122192,
-0.11405318230390549,
-0.1845182627439499,
-0.08780328184366226,
0.21334215998649597,
0.051452890038490295,
0.07998060435056686,
-0.13153426349163055,
-0.11966050416231155,
-0.10807180404663086,
-0.2187342792749405,
0.12637819349765778,
-0.007480150554329157,
-0.019326740875840187,
-0.07732157409191132,
0.0202597938477993,
0.034946661442518234,
-0.10724654793739319,
-0.01874653436243534,
0.02052006684243679,
0.12350336462259293,
-0.10929697006940842,
0.11888142675161362,
-0.02886316180229187,
0.16757133603096008,
-0.06275589764118195,
0.0088746203109622,
-0.31040745973587036,
-0.07496312260627747,
-0.2530212104320526,
0.26025423407554626,
0.008682863786816597,
0.10298703610897064,
-0.00586139690130949,
0.008259005844593048,
0.02480972930788994,
0.042051006108522415,
0.05544503778219223,
-0.09766614437103271,
-0.001981824403628707,
-0.06655631214380264,
0.04522879794239998,
-0.0699903666973114,
0.01211047824472189,
-0.024420861154794693,
-0.1056651845574379,
0.0004587737494148314,
0.11856943368911743,
0.03647276759147644,
0.0028747350443154573,
-0.06372193247079849,
0.015243547037243843,
-0.030910659581422806,
0.15386657416820526,
-0.15237613022327423,
0.048692237585783005,
0.03815964609384537,
-0.0844372883439064,
0.08749007433652878,
-0.06035900115966797,
0.14516369998455048,
0.14906050264835358,
0.20223911106586456,
0.021725036203861237,
-0.11631254106760025,
-0.041304249316453934,
0.007539207115769386,
-0.15258952975273132,
0.14545443654060364,
-0.25988152623176575,
0.05514873191714287,
-0.13746421039104462,
0.006643419619649649,
0.1491946429014206,
0.0579838901758194,
-0.022479409351944923,
0.16320763528347015,
-0.17853513360023499,
-0.04727509617805481,
0.09550312161445618,
0.14350831508636475,
0.003352636704221368,
-0.13444562256336212,
0.10442393273115158,
-0.04019996523857117,
0.00810046587139368,
-0.021560102701187134,
0.08368609845638275,
-0.1944325566291809,
0.12933127582073212,
-0.043012555688619614,
-0.2918175458908081,
-0.12719975411891937,
-0.10835757106542587,
0.12403037399053574,
0.01621169038116932,
-0.02955167181789875,
0.0013169832527637482,
0.08000509440898895,
-0.02371405065059662,
-0.09072302281856537,
-0.16063974797725677,
0.13516421616077423,
0.22009363770484924,
-0.12330823391675949,
-0.16295132040977478,
0.09349354356527328,
0.045860905200242996,
-0.10443666577339172,
-0.09475123137235641,
0.09748826175928116,
-0.06351562589406967,
-0.0014141915598884225,
0.19635316729545593,
0.16587059199810028,
-0.12472259253263474,
0.2981950044631958,
-0.07193201780319214,
0.09846480190753937,
-0.04038167744874954,
-0.09547723084688187,
-0.07525546103715897,
-0.15339559316635132,
0.05509791150689125,
-0.0774262398481369,
0.04480954259634018,
-0.13010673224925995,
0.07751888781785965,
0.04695209115743637,
0.0502333790063858,
0.09714455902576447,
0.16142359375953674,
-0.19884748756885529,
-0.07290131598711014,
0.12024030089378357,
0.0759110376238823,
0.01097707450389862,
0.13476309180259705,
0.10036126524209976,
-0.04139265418052673,
-0.2304578423500061,
-0.2502646744251251,
-0.17563821375370026,
0.1746426224708557,
-0.06150204688310623,
0.04155215620994568,
-0.004658108111470938,
-0.09041966497898102,
0.004933053627610207,
0.17277754843235016,
0.03944562003016472,
0.20035947859287262,
-0.00807341281324625,
-0.05845244228839874,
0.19889280200004578,
0.13987906277179718,
-0.0027658070903271437,
-0.1359110176563263,
-0.1442805677652359,
-0.2987953722476959,
0.06839034706354141,
0.072786346077919,
-0.05381138622760773,
0.0008075222140178084,
-0.12596839666366577,
0.08466033637523651,
-0.06380883604288101,
-0.09670829027891159,
0.04364507272839546,
0.11973258852958679,
-0.13178253173828125,
0.04418767988681793,
-0.05967044085264206,
0.04326517507433891,
0.03469639644026756,
-0.012377751059830189,
0.0007950786384753883,
-0.0009412289364263415
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. authors recommend:Annual:Skin examination for evidence of malignant transformation in persons with chronic recalcitrant skin ulcersComplete blood countLiver function testsAbdominal ultrasound examination to assess liver and spleen sizeFollow up as recommended by a pulmonologist and immunologist;Follow-up assessments of motor and cognitive development as recommended for educational planning.Agents/Circumstances to AvoidIndividuals with prolidase deficiency who have splenomegaly should avoid contact sports given the increased risk for splenic rupture.Evaluation of Relatives at RiskSee Genetic Counseling for issues related to testing of at-risk relatives for genetic counseling purposes.Therapies Under InvestigationAdenovirus-mediated gene transfer.
Ikeda et al performed transfer of the human prolidase cDNA into fibroblasts from patients with prolidase deficiency. This increased the fibroblast prolidase activity up to 75 times normal.Intracellular delivery of liposome-encapsulated prolidase.
Perugini et al showed that active prolidase encapsulated in liposomes was completely transported via endocytosis into fibroblasts six days after incubation | [
-0.16542015969753265,
0.1088678240776062,
-0.09182185679674149,
-0.26261448860168457,
0.07007452845573425,
0.044126834720373154,
-0.026975134387612343,
-0.09443123638629913,
-0.1349201798439026,
-0.0799541175365448,
0.13578294217586517,
0.11742371320724487,
0.13358117640018463,
0.142067551612854,
-0.18283839523792267,
0.0971493348479271,
0.021026363596320152,
-0.13068385422229767,
-0.01946478895843029,
0.11662958562374115,
0.11590110510587692,
-0.11556451767683029,
0.3110193908214569,
0.14872212707996368,
0.07396160066127777,
-0.01406126469373703,
0.006151753943413496,
0.04188784584403038,
-0.06910785287618637,
0.13759061694145203,
0.17803026735782623,
0.03566484525799751,
0.015559449791908264,
-0.18259412050247192,
-0.018458370119333267,
0.01148569118231535,
-0.18972265720367432,
-0.04668847844004631,
0.23506402969360352,
-0.008951925672590733,
-0.1472693532705307,
-0.030822664499282837,
0.05806828290224075,
0.08232608437538147,
0.09513992071151733,
-0.26719021797180176,
0.08274325728416443,
0.0400066040456295,
-0.0787239670753479,
0.11563348025083542,
0.1353815644979477,
-0.12848147749900818,
0.09667961299419403,
-0.10097769647836685,
0.1888531595468521,
0.11123230308294296,
-0.04455321654677391,
0.1249161809682846,
-0.14311537146568298,
0.12845763564109802,
0.18985269963741302,
-0.11369041353464127,
-0.03619757667183876,
-0.2918183505535126,
0.27941417694091797,
0.09441699087619781,
-0.016276894137263298,
-0.12694703042507172,
-0.0630369484424591,
-0.0066864266991615295,
0.2909412682056427,
0.0354170948266983,
0.1460713893175125,
0.020538920536637306,
-0.008249761536717415,
0.05907797813415527,
0.022689517587423325,
-0.15979963541030884,
0.1641813963651657,
-0.298442006111145,
-0.0548131950199604,
0.11212388426065445,
-0.016389857977628708,
0.07797034084796906,
0.02608306333422661,
0.2108537256717682,
0.04445376992225647,
0.1017540767788887,
0.04548715054988861,
-0.03165070712566376,
-0.029529796913266182,
-0.06702841073274612,
0.005355075467377901,
-0.012349731288850307,
0.007735511753708124,
-0.18346232175827026,
-0.14403927326202393,
0.14815554022789001,
0.050367437303066254,
0.20951390266418457,
0.07922738045454025,
-0.01203631330281496,
0.016828464344143867,
0.09755280613899231,
0.07095988839864731,
-0.1163456067442894,
-0.1766790747642517,
-0.05923676863312721,
-0.07543552666902542,
-0.01759205013513565,
0.12356958538293839,
0.0616607666015625,
-0.09865260869264603,
0.006082836072891951,
-0.09538418054580688,
-0.015190602280199528,
0.12589024007320404,
0.039969827979803085,
0.03554610535502434,
-0.03194328770041466,
-0.06777290254831314,
0.00033077699481509626,
0.08100056648254395,
-0.027776964008808136,
0.14765551686286926,
0.15436802804470062,
-0.0320071242749691,
0.07906221598386765,
0.11807788908481598,
0.11412016302347183,
-0.0036624956410378218,
0.05486293509602547,
-0.07470918446779251,
-0.047111768275499344,
-0.09171947091817856,
-0.03503179922699928,
-0.20337232947349548,
-0.08370780199766159,
-0.04574985429644585,
-0.019453391432762146,
0.050615813583135605,
-0.02295353077352047,
0.2240239828824997,
0.31900882720947266,
-0.19825035333633423,
0.0955047681927681,
0.2284245491027832,
0.08386532962322235,
0.046904999762773514,
-0.03534506633877754,
0.1314648687839508,
-0.14700235426425934,
0.2697564661502838,
-0.08728879690170288,
-0.07483521848917007,
-0.08926376700401306,
-0.09719167649745941,
-0.0079385656863451,
-0.06729118525981903,
-0.03398098424077034,
0.12805487215518951,
-0.0314466692507267,
0.1712447553873062,
-0.05583375692367554,
0.12585456669330597,
0.017761394381523132,
0.008417632430791855,
0.04114660620689392,
0.08224997669458389,
-0.0031193105969578028,
-0.10289008170366287,
0.1091652363538742,
0.020361999049782753,
-0.08942151069641113,
0.14667218923568726,
0.12018318474292755,
0.01588181033730507,
0.005045290105044842,
0.03968643769621849,
-0.06882584095001221,
0.006222366821020842,
0.06042051315307617,
-0.04520256072282791,
-0.006028851959854364,
-0.0200649444013834,
-0.139055073261261,
0.008271035738289356,
0.23323974013328552,
0.035056859254837036,
0.10135407745838165,
0.08847881853580475,
0.10696534067392349,
-0.03675476834177971,
-0.1664409190416336,
0.19340911507606506,
-0.10466533154249191,
0.07475375384092331,
0.03260530158877373,
-0.1311035007238388,
-0.03758643567562103,
0.07452194392681122,
-0.11251614987850189,
0.11588477343320847,
-0.045032281428575516,
-0.05488196760416031,
-0.10167946666479111,
-0.03288302198052406,
-0.0432216115295887,
-0.10728763788938522,
0.20212699472904205,
-0.07690007239580154,
-0.06004767864942551,
-0.006193164736032486,
0.1297396719455719,
-0.011859679594635963,
-0.010451401583850384,
-0.19299450516700745,
-0.045790597796440125,
0.021216874942183495,
-0.17268945276737213,
-0.03732568770647049,
0.10905838757753372,
0.07221704721450806,
-0.26988160610198975,
-0.10464585572481155,
-0.009725477546453476,
-0.055680789053440094,
0.07483229786157608,
-0.04726603999733925,
-0.0167549941688776,
-0.049331992864608765,
0.18817608058452606,
-0.03131886571645737,
0.061304401606321335,
-0.13457123935222626,
-0.10063714534044266,
-0.01430880930274725,
0.20670625567436218,
0.080510213971138,
-0.0029841861687600613,
-0.09880272299051285,
0.12192890048027039,
0.13592751324176788,
-0.0884455144405365,
-0.10728809982538223,
0.021566612645983696,
0.010720334015786648,
0.10887022316455841,
-0.01197594590485096,
-0.009856412187218666,
-0.08676504343748093,
0.09758296608924866,
0.04272201657295227,
-0.028091760352253914,
-0.3054143786430359,
0.016966858878731728,
0.05115615576505661,
0.017506999894976616,
0.09083475172519684,
-0.033581770956516266,
-0.01463781576603651,
-0.035653453320264816,
0.10171706229448318,
-0.04480903595685959,
0.032039690762758255,
-0.08689842373132706,
-0.12823940813541412,
0.07416509836912155,
-0.11908850818872452,
-0.14781661331653595,
-0.11466296762228012,
0.03224131092429161,
0.14226695895195007,
0.11353026330471039,
-0.23627008497714996,
-0.08768776804208755,
-0.24426254630088806,
-0.057066697627305984,
0.2870757281780243,
0.005477979313582182,
0.043494146317243576,
0.032892875373363495,
-0.037604920566082,
-0.0726354643702507,
0.03382482752203941,
-0.054460469633340836,
0.11314096301794052,
0.020385170355439186,
-0.012407518923282623,
0.025936048477888107,
0.13669608533382416,
0.11194116622209549,
-0.07076267153024673,
-0.07732657343149185,
-0.019511761143803596,
-0.03328073397278786,
-0.0696302130818367,
0.010878747329115868,
0.04848553240299225,
0.04071678966283798,
0.11071417480707169,
0.166488915681839,
-0.10110129415988922,
-0.11438263952732086,
-0.011408963240683079,
-0.059952832758426666,
0.05911906436085701,
0.10482749342918396,
-0.13701272010803223,
0.19687524437904358,
-0.17299515008926392,
0.07494045794010162,
-0.05665527284145355,
-0.04158904775977135,
-0.050416138023138046,
-0.02881617285311222,
-0.2550693154335022,
0.08423109352588654,
0.04312978312373161,
0.06049468368291855,
0.19768944382667542,
0.000028909167667734437,
-0.0212711151689291,
0.15952004492282867,
0.08774416148662567,
-0.011820183135569096,
0.00254177232272923,
0.08324982970952988,
0.010087740607559681,
-0.06381285190582275,
-0.01990329660475254,
0.07587214559316635,
-0.05071122944355011,
0.05402388051152229,
0.05175096169114113,
-0.0993148535490036,
0.19378741085529327,
-0.07389786839485168,
-0.09914644062519073,
-0.05830340087413788,
0.0803387239575386,
-0.057710666209459305,
0.10323790460824966,
-0.06525103747844696,
-0.1745356172323227,
0.013299025595188141,
0.1134222075343132,
0.015184223651885986,
0.02651354856789112,
0.016726695001125336,
-0.0644533559679985,
-0.18967780470848083,
0.11268644779920578,
-0.21481706202030182,
0.09344291687011719,
0.12320656329393387,
-0.0632934719324112,
-0.003851386485621333,
0.15668781101703644,
-0.15687231719493866,
-0.13429699838161469,
0.09305126219987869,
0.20965301990509033,
-0.12022804468870163,
0.27439451217651367,
0.18955184519290924,
0.10032906383275986,
0.12402721494436264,
0.12368908524513245,
0.13260294497013092,
0.09446103125810623,
0.01917078159749508,
0.11436745524406433,
0.008630795404314995,
-0.0738518238067627,
-0.0961003378033638,
-0.11376407742500305,
0.17013894021511078,
-0.07336506247520447,
-0.07070767134428024,
-0.0296472255140543,
-0.02610384300351143,
0.14629562199115753,
0.17173190414905548,
0.007945094257593155,
0.07683584839105606,
-0.20624218881130219,
0.027850255370140076,
-0.05402915179729462,
-0.25503721833229065,
0.040772002190351486,
0.19336363673210144,
0.007168343290686607,
0.041212137788534164,
-0.11438928544521332,
0.01947573386132717,
0.03701181709766388,
-0.06522879749536514,
-0.12237773090600967,
-0.004667581524699926,
-0.051754046231508255,
-0.10580457001924515,
0.13248442113399506,
0.08542248606681824,
0.030162468552589417,
-0.018883049488067627,
-0.07116644084453583,
0.19820809364318848,
0.05715204402804375,
-0.015001997351646423,
0.04680739343166351,
0.012015330605208874,
-0.019533205777406693,
-0.034417156130075455,
0.025844793766736984,
-0.025938399136066437,
-0.05135645344853401,
0.04231835529208183,
0.23470400273799896,
-0.055383093655109406,
-0.16509273648262024,
-0.13801594078540802,
0.18098649382591248,
-0.1438518762588501,
-0.0932302176952362,
0.03493303805589676,
0.1025959700345993,
-0.0023233238607645035,
0.0245373472571373,
0.14349307119846344,
0.23649819195270538,
0.05842716619372368,
0.016042770817875862,
0.07302805781364441,
0.20064029097557068,
0.03744681179523468,
0.11958052217960358,
0.09118686616420746,
0.14402702450752258,
0.0044545200653374195,
0.14426842331886292,
0.11571748554706573,
-0.1555977463722229,
0.020491989329457283,
-0.029807258397340775,
0.0036147357895970345,
0.0059663113206624985,
-0.0377131812274456,
0.06026894971728325,
-0.07297845184803009,
-0.03004312328994274,
-0.03745448216795921,
0.1790475994348526,
0.01725810207426548,
-0.06798447668552399,
0.21544526517391205,
-0.02373438887298107,
0.06299810111522675,
0.01588839292526245,
-0.03472506254911423,
-0.06319579482078552,
0.019713878631591797,
0.11789906769990921,
-0.0010833041742444038,
0.07699976116418839,
0.11744677275419235,
-0.16163772344589233,
-0.05111173167824745,
-0.06689539551734924,
0.017226606607437134,
0.20970261096954346,
-0.009030596353113651,
0.011487946845591068,
0.10781141370534897,
-0.12632952630519867,
-0.012738385237753391,
0.054678577929735184,
0.06036463379859924,
-0.026468168944120407,
0.07515379041433334,
-0.09599953889846802,
0.04591630771756172,
-0.11853952705860138,
-0.041260309517383575,
0.021459266543388367,
-0.03995471075177193,
0.04310736060142517,
-0.0980977937579155,
0.17370998859405518,
0.09202778339385986,
0.049657855182886124,
-0.0549517460167408,
0.07148054987192154,
0.12696875631809235,
0.01256611943244934,
-0.1708448976278305,
-0.06058117374777794,
-0.08621347695589066,
0.005407709628343582,
-0.11239396035671234,
0.09153158962726593,
-0.00777483033016324,
0.021078379824757576,
0.2495032250881195,
-0.03119785152375698,
0.07687747478485107,
-0.12197520583868027,
-0.06044210493564606,
0.11787678301334381,
0.17022277414798737,
0.19202134013175964,
0.059756822884082794,
0.05968838185071945,
-0.056955933570861816,
-0.0832216665148735,
-0.12964093685150146,
0.12304788827896118,
0.12228797376155853,
0.05379234254360199,
0.02525397390127182,
0.0905434787273407,
0.025581343099474907,
-0.0038939379155635834,
0.06763705611228943,
-0.04573081061244011,
-0.10204145312309265,
-0.07082558423280716,
0.029520196840167046,
-0.2044379711151123,
-0.26755762100219727,
-0.006368489004671574,
-0.2033197432756424,
-0.0001244015438714996,
-0.12504123151302338,
0.1068805381655693,
-0.028987746685743332,
-0.05546967312693596,
-0.0419904999434948,
-0.1549246907234192,
-0.07000904530286789,
0.040664300322532654,
-0.009067026898264885,
0.02318742498755455,
0.10290764272212982,
-0.27801039814949036,
0.08902884274721146,
-0.02129337750375271,
-0.004473936278373003,
-0.026463013142347336,
0.1311739981174469,
-0.03731035813689232,
0.15081031620502472,
0.07028590887784958,
0.08318112790584564,
0.005110954865813255,
-0.1574072241783142,
0.09269595146179199,
-0.05911706015467644,
-0.07092519104480743,
0.02500211074948311,
-0.004090116359293461,
-0.1361319124698639,
-0.07421168684959412,
-0.10607300698757172,
-0.023954259231686592,
0.061163850128650665,
0.009907500818371773,
-0.11794895678758621,
0.0892009362578392,
-0.10024043172597885,
-0.12262698262929916,
-0.117989681661129,
-0.025023726746439934,
-0.18608734011650085,
-0.0005298624746501446,
0.11635550111532211,
-0.10627920180559158,
-0.07386942207813263,
-0.036562833935022354,
0.19690436124801636,
-0.08614090830087662,
-0.0645773783326149,
-0.17890557646751404,
0.09425757080316544,
-0.022386208176612854,
0.16103771328926086,
-0.000674991519190371,
-0.0083110136911273,
0.07253202050924301,
0.09843993186950684,
0.09203074872493744,
-0.07884815335273743,
-0.1326049268245697,
-0.07488200813531876,
0.15135180950164795,
-0.03434254229068756,
0.09868451207876205,
-0.1783682405948639,
-0.05660998821258545,
0.026755915954709053,
-0.1554977148771286,
0.17027100920677185,
-0.029118910431861877,
-0.0769810602068901,
-0.051093198359012604,
0.023872800171375275,
0.027632705867290497,
-0.141519695520401,
0.08782757073640823,
-0.026675159111618996,
0.08441801369190216,
-0.12161119282245636,
0.042877838015556335,
-0.00292997807264328,
0.19542138278484344,
0.04486214369535446,
-0.0015276649501174688,
-0.22903789579868317,
-0.04896315559744835,
-0.19984407722949982,
0.16716767847537994,
0.11529413610696793,
0.060871560126543045,
-0.03786621615290642,
0.04745682328939438,
0.01298461202532053,
0.045944467186927795,
0.0437903068959713,
-0.05747327581048012,
0.05339498817920685,
-0.12638364732265472,
-0.03169703111052513,
0.0021475558169186115,
-0.0740179494023323,
-0.0714021548628807,
-0.038313474506139755,
0.0005270557012408972,
0.1841268241405487,
0.16247591376304626,
-0.07954928278923035,
-0.05866427719593048,
0.06211487576365471,
-0.06400787830352783,
0.16636952757835388,
-0.06905277073383331,
0.12309727817773819,
-0.018618855625391006,
-0.013444795273244381,
-0.03592075780034065,
-0.04994236305356026,
-0.014164460822939873,
0.08747903257608414,
0.07445772737264633,
-0.0360201857984066,
-0.049137651920318604,
-0.017736932262778282,
0.04429136961698532,
-0.12713949382305145,
0.14004307985305786,
-0.1220356747508049,
0.02898559719324112,
-0.08139397948980331,
-0.11247824877500534,
0.1320604681968689,
0.09160158038139343,
0.008371014147996902,
0.09708765149116516,
-0.05213537439703941,
-0.04366893693804741,
0.06301724910736084,
0.204328253865242,
0.11952092498540878,
-0.17207874357700348,
0.10335486382246017,
-0.030218513682484627,
-0.016108263283967972,
-0.08631615340709686,
0.03296814113855362,
-0.14552661776542664,
0.12101006507873535,
0.046785131096839905,
-0.12762649357318878,
-0.01870882697403431,
-0.15044112503528595,
0.05905770882964134,
0.07026340067386627,
-0.06738186627626419,
0.0516151562333107,
0.058415208011865616,
0.04342573508620262,
-0.07018164545297623,
-0.16103312373161316,
0.17776435613632202,
0.16006030142307281,
-0.09440932422876358,
-0.052554842084646225,
0.17466585338115692,
0.09817486256361008,
-0.10448446124792099,
-0.09766519069671631,
0.15817168354988098,
0.030001120641827583,
-0.011165332049131393,
0.2149171233177185,
0.07155729830265045,
-0.033630743622779846,
0.23676790297031403,
-0.021632257848978043,
-0.019977115094661713,
-0.03226281702518463,
-0.07412055134773254,
-0.03205244243144989,
-0.10507965832948685,
0.0659835934638977,
-0.03410918638110161,
0.17273782193660736,
-0.09954704344272614,
0.0751509740948677,
0.044377777725458145,
0.04425175487995148,
0.028923505917191505,
0.18532294034957886,
-0.04486943781375885,
-0.07599419355392456,
0.1731194108724594,
0.0583919994533062,
0.004440539050847292,
0.10837674140930176,
0.12256744503974915,
-0.04927736520767212,
-0.07973387837409973,
-0.1913028359413147,
-0.08845649659633636,
0.082952581346035,
-0.09232951700687408,
-0.003937019966542721,
0.07884903252124786,
-0.0034442672040313482,
0.04313362017273903,
0.16981099545955658,
-0.000547020579688251,
0.13786716759204865,
-0.023050641641020775,
-0.11254458874464035,
0.10523249208927155,
0.04874175414443016,
-0.033284202218055725,
-0.13973692059516907,
-0.12335769087076187,
-0.19483232498168945,
0.13578689098358154,
0.06736531108617783,
-0.06117710471153259,
0.028499910607933998,
-0.10545646399259567,
0.15589110553264618,
-0.014184513129293919,
-0.03496744856238365,
0.052562590688467026,
0.002100326120853424,
-0.11853188276290894,
0.05359220132231712,
-0.06989964097738266,
-0.0193952564150095,
-0.0336466021835804,
-0.011356779374182224,
-0.00041292831883765757,
-0.03275226429104805
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK299584/ | NrrA826 | Prolidase Deficiency | C0268532 | 31,758 | prolidase deficiency. of Relatives at RiskSee Genetic Counseling for issues related to testing of at-risk relatives for genetic counseling purposes.Therapies Under InvestigationAdenovirus-mediated gene transfer.
Ikeda et al performed transfer of the human prolidase cDNA into fibroblasts from patients with prolidase deficiency. This increased the fibroblast prolidase activity up to 75 times normal.Intracellular delivery of liposome-encapsulated prolidase.
Perugini et al showed that active prolidase encapsulated in liposomes was completely transported via endocytosis into fibroblasts six days after incubation.Search ClinicalTrials.gov in the US and www.ClinicalTrialsRegister.eu in Europe for access to information on clinical studies for a wide range of diseases and conditions. | [
-0.27767062187194824,
0.01454999390989542,
-0.050771839916706085,
-0.0038672226946800947,
0.037748828530311584,
0.07645653188228607,
0.01692102663218975,
-0.04416622593998909,
-0.160804882645607,
-0.010020259767770767,
0.08209599554538727,
0.12529277801513672,
0.18217746913433075,
0.19394437968730927,
-0.17674510180950165,
0.09719251841306686,
0.04736689105629921,
-0.10692871361970901,
0.016943786293268204,
0.023975683376193047,
0.13101306557655334,
-0.10257351398468018,
0.3271210491657257,
0.21153759956359863,
-0.033112019300460815,
0.07304392009973526,
0.012177643366158009,
0.01888863742351532,
0.001614419394172728,
0.15520569682121277,
0.19082912802696228,
-0.0008130591013468802,
-0.03472527489066124,
-0.16884064674377441,
0.043641846626996994,
-0.06477148830890656,
0.029104171320796013,
-0.06335550546646118,
0.17755770683288574,
-0.07758472859859467,
-0.12211278825998306,
-0.028192536905407906,
0.12330633401870728,
0.03519190847873688,
0.1055208072066307,
-0.20981557667255402,
0.17202191054821014,
0.14701469242572784,
-0.019368216395378113,
0.0662701427936554,
0.24440163373947144,
-0.2200123369693756,
0.09939901530742645,
-0.03443162888288498,
0.15213216841220856,
0.13009460270404816,
0.04884572699666023,
0.1653633862733841,
-0.15629109740257263,
0.004534674808382988,
0.018628405407071114,
0.026989107951521873,
-0.06549128144979477,
-0.33318766951560974,
0.20858274400234222,
0.042592987418174744,
0.06662697345018387,
-0.18030789494514465,
0.008783369325101376,
0.07583009451627731,
0.18144692480564117,
0.004792656749486923,
0.20794546604156494,
0.021151619032025337,
-0.09264404326677322,
0.15274323523044586,
0.11486347764730453,
-0.17888107895851135,
0.08280706405639648,
-0.06581725180149078,
-0.12883108854293823,
0.1496497392654419,
0.08696160465478897,
0.06455659866333008,
0.06420427560806274,
0.19963029026985168,
0.07576090097427368,
0.18759623169898987,
0.06316591799259186,
0.010732092894613743,
-0.0379035510122776,
-0.11203218996524811,
0.06972973048686981,
0.007610220927745104,
-0.08725255727767944,
-0.061708275228738785,
-0.05444556847214699,
0.06431858986616135,
0.14852997660636902,
0.1850869208574295,
0.24434438347816467,
-0.05558869242668152,
-0.07488258928060532,
-0.051263049244880676,
0.10819492489099503,
0.022947881370782852,
-0.09478433430194855,
0.0046944874338805676,
-0.05331101268529892,
0.019505131989717484,
0.06659336388111115,
-0.031105678528547287,
-0.05829564109444618,
0.03877740353345871,
-0.05233075097203255,
-0.04497088864445686,
0.10147970169782639,
0.03195275738835335,
0.0006676673074252903,
0.05872594565153122,
-0.0746304839849472,
-0.007272385526448488,
0.02297511324286461,
-0.10644958913326263,
0.027795761823654175,
0.2315000295639038,
-0.10173525661230087,
0.11938034743070602,
0.13661929965019226,
0.035480059683322906,
0.03913991153240204,
0.026549942791461945,
-0.022902309894561768,
0.04339073225855827,
-0.12478885054588318,
-0.08613016456365585,
-0.048514023423194885,
-0.07418692111968994,
0.07779048383235931,
0.03745856508612633,
0.018505321815609932,
0.0701843872666359,
0.20859138667583466,
0.21067050099372864,
0.037536706775426865,
0.08928488940000534,
0.1111006885766983,
0.02486688457429409,
0.13689973950386047,
0.032254546880722046,
0.008243978023529053,
-0.11898862570524216,
0.32756730914115906,
0.012047231197357178,
-0.05670545622706413,
-0.13654954731464386,
-0.001456688274629414,
0.04438940808176994,
-0.144659161567688,
0.03630225732922554,
0.06307852268218994,
-0.07184519618749619,
0.16062316298484802,
-0.06363590806722641,
0.16384008526802063,
0.07096859812736511,
-0.10288305580615997,
0.1357278674840927,
0.0926794782280922,
-0.03087504580616951,
-0.14391997456550598,
0.11513284593820572,
-0.03775689750909805,
-0.03244121000170708,
0.13148652017116547,
-0.02931392192840576,
0.14747466146945953,
-0.09693213552236557,
-0.031296756118535995,
-0.03307857736945152,
0.057623203843832016,
-0.017834030091762543,
-0.03469935059547424,
0.06934911012649536,
-0.22235453128814697,
0.003714335849508643,
0.22785943746566772,
0.22831183671951294,
0.08189276605844498,
0.08021032065153122,
0.18712399899959564,
0.11058590561151505,
-0.03969482704997063,
-0.13962793350219727,
0.14385877549648285,
-0.10861741751432419,
0.005903280805796385,
-0.007639378774911165,
-0.08275215327739716,
-0.0348844937980175,
0.09314989298582077,
-0.14076638221740723,
0.10235605388879776,
-0.014385330490767956,
-0.010079797357320786,
-0.03729582577943802,
0.02086533233523369,
0.020397040992975235,
-0.08053673803806305,
0.2042076140642166,
-0.1048588752746582,
0.025223301723599434,
-0.023098032921552658,
0.03803781419992447,
-0.024093596264719963,
-0.04078543931245804,
-0.1287301629781723,
-0.05633532628417015,
0.06833923608064651,
0.03540899604558945,
-0.05870354175567627,
0.18573042750358582,
-0.018722161650657654,
-0.13857607543468475,
-0.09788794070482254,
0.11038676649332047,
-0.16347019374370575,
0.09300779551267624,
0.029740145429968834,
0.01881692185997963,
0.049615710973739624,
0.08571348339319229,
0.05583721026778221,
0.09408722072839737,
-0.22805288434028625,
0.029401907697319984,
0.045603856444358826,
0.0700913593173027,
0.11992046982049942,
0.038019560277462006,
-0.23669230937957764,
0.03236210346221924,
0.11098217964172363,
-0.05445266142487526,
0.017872147262096405,
0.06374098360538483,
-0.08186186850070953,
0.05655653402209282,
-0.09138451516628265,
0.07188916206359863,
-0.055128902196884155,
0.0840734988451004,
0.12514080107212067,
-0.1349053531885147,
-0.3168571889400482,
0.1362098604440689,
-0.007267883513122797,
-0.006111781578511,
0.015523266047239304,
-0.08980774879455566,
-0.018377268686890602,
-0.03930564969778061,
0.13826444745063782,
0.02273237332701683,
0.1308271735906601,
-0.006869173608720303,
-0.13889823853969574,
0.19666823744773865,
-0.13889369368553162,
-0.24920590221881866,
-0.20952670276165009,
0.023373646661639214,
0.08668752014636993,
0.023328101262450218,
-0.16210338473320007,
0.005003463942557573,
-0.1509075164794922,
-0.02013881504535675,
0.10943692922592163,
0.008041251450777054,
-0.08939698338508606,
0.14804711937904358,
-0.14803357422351837,
0.04815197363495827,
0.21641407907009125,
-0.04948550835251808,
0.14883968234062195,
0.10105331987142563,
-0.14372815191745758,
0.12367347627878189,
0.1550014466047287,
0.07269150018692017,
-0.1397857367992401,
-0.14065684378147125,
0.03120378591120243,
0.06883791834115982,
-0.04445343837141991,
0.06830400973558426,
0.10930584371089935,
-0.07531014829874039,
0.08368398994207382,
0.04953118413686752,
0.007511212956160307,
-0.14048220217227936,
-0.10696069896221161,
-0.0832720696926117,
0.08564715832471848,
0.022125786170363426,
-0.08922145515680313,
0.1574060320854187,
-0.08127037435770035,
0.059812817722558975,
-0.07435397803783417,
-0.092379130423069,
0.04468875005841255,
-0.07101314514875412,
-0.17429715394973755,
0.06428651511669159,
0.04730797931551933,
0.17520521581172943,
0.1941705197095871,
-0.023579122498631477,
0.04456807300448418,
0.1205325797200203,
-0.15331701934337616,
-0.022551467642188072,
-0.11344834417104721,
0.02444968931376934,
-0.03881412744522095,
0.030253520235419273,
-0.043560586869716644,
0.03925057500600815,
-0.005783064290881157,
0.04971156641840935,
0.038977570831775665,
-0.08159235119819641,
0.12325900793075562,
-0.03473851829767227,
-0.04630526155233383,
0.06077340990304947,
0.09209824353456497,
-0.09775647521018982,
-0.040115393698215485,
0.01931043155491352,
-0.03789757564663887,
-0.15107671916484833,
0.10858144611120224,
-0.17493239045143127,
0.23803502321243286,
0.03855867683887482,
-0.018773244693875313,
0.028909824788570404,
-0.057955365628004074,
-0.13981954753398895,
0.1063799187541008,
-0.03632571920752525,
-0.004712902475148439,
0.016820505261421204,
0.11725973337888718,
-0.045685775578022,
-0.09495507180690765,
0.014937416650354862,
0.20055364072322845,
0.02727033942937851,
0.17259642481803894,
0.026200756430625916,
0.2329384684562683,
0.1726941019296646,
-0.03403458744287491,
0.07444994896650314,
0.04385126009583473,
-0.0911833867430687,
0.019677871838212013,
0.01865733228623867,
-0.05402529984712601,
-0.0376235768198967,
-0.08481843024492264,
0.21397428214550018,
0.049310363829135895,
-0.011442950926721096,
0.02979443408548832,
0.02293950878083706,
0.1494377851486206,
0.09222232550382614,
0.11670362204313278,
0.17249885201454163,
-0.10314391553401947,
-0.15913638472557068,
0.11745196580886841,
-0.10977011173963547,
0.013502457179129124,
0.21320845186710358,
-0.07370531558990479,
-0.004026681650429964,
-0.04955530911684036,
0.03326515853404999,
-0.06557908654212952,
0.004669409245252609,
-0.15313561260700226,
-0.11454401165246964,
-0.04288504272699356,
-0.1576947122812271,
0.04836732894182205,
0.11631232500076294,
-0.02865518443286419,
-0.022867171093821526,
-0.1352834552526474,
0.23054584860801697,
0.03331885114312172,
-0.03959421440958977,
0.07128612697124481,
0.13050517439842224,
-0.14818599820137024,
-0.07162903994321823,
0.19038796424865723,
0.06606411933898926,
0.10638727247714996,
0.003065643599256873,
-0.04960286244750023,
0.07761946320533752,
-0.1272168904542923,
-0.12412184476852417,
0.14174531400203705,
0.009385554119944572,
-0.0019549427088350058,
-0.04809707775712013,
0.04241257533431053,
-0.045569341629743576,
0.0379306934773922,
0.22896631062030792,
0.15483935177326202,
0.19975224137306213,
-0.05074867606163025,
0.0436708964407444,
0.12355630099773407,
0.04320063814520836,
0.12329091131687164,
0.03769098222255707,
0.22335821390151978,
0.0913819819688797,
0.10495734214782715,
0.005324853118509054,
-0.195952370762825,
0.02165571227669716,
-0.03508425131440163,
-0.050755929201841354,
0.037869490683078766,
-0.0063466401770710945,
-0.002508056117221713,
0.06274764239788055,
0.006401933263987303,
0.04207156226038933,
0.1908174753189087,
0.07139339298009872,
-0.08468528091907501,
0.1703956574201584,
-0.00168898596893996,
0.00945331621915102,
-0.049829982221126556,
0.03381200134754181,
-0.01588243804872036,
0.129836305975914,
-0.05254796892404556,
0.06677405536174774,
0.0378497838973999,
0.08703462034463882,
-0.16167402267456055,
-0.034639932215213776,
-0.009027445688843727,
-0.0260136928409338,
0.25814980268478394,
-0.011777589097619057,
-0.1742214560508728,
0.034339286386966705,
-0.061105042695999146,
-0.05719190835952759,
-0.03217751532793045,
0.14211350679397583,
-0.07952861487865448,
0.013166154734790325,
-0.1261167675256729,
0.030774209648370743,
-0.10022027045488358,
-0.11931493878364563,
-0.05840473622083664,
-0.002200447954237461,
0.054594092071056366,
-0.030187394469976425,
-0.003134417813271284,
0.16244682669639587,
-0.025232868269085884,
0.09706144034862518,
0.13594423234462738,
0.0689166709780693,
-0.02526121214032173,
-0.17466072738170624,
-0.13783378899097443,
-0.057711780071258545,
-0.09368456155061722,
-0.028001289814710617,
0.04790510609745979,
0.014772538095712662,
0.10812739282846451,
0.2864623963832855,
0.009323840029537678,
-0.13408009707927704,
-0.004365887958556414,
-0.089509017765522,
0.18290795385837555,
0.14337866008281708,
0.06505174934864044,
0.14498434960842133,
0.018060140311717987,
0.02087440714240074,
-0.057039596140384674,
-0.09944398701190948,
0.07021278887987137,
0.12722358107566833,
-0.053136132657527924,
-0.06592234969139099,
-0.03471927344799042,
-0.10462573915719986,
0.0217638798058033,
0.11893642693758011,
-0.03950018808245659,
-0.1544138342142105,
-0.028440479189157486,
0.013088962994515896,
-0.08452489972114563,
-0.07478974759578705,
-0.027181582525372505,
-0.10854245722293854,
-0.13716909289360046,
-0.146549791097641,
0.08110468089580536,
0.028421811759471893,
-0.02789946272969246,
-0.008885661140084267,
-0.13638842105865479,
-0.07923944294452667,
0.04114631563425064,
-0.07131236791610718,
-0.002447250997647643,
0.03124820813536644,
-0.14007370173931122,
0.15013931691646576,
-0.1094888374209404,
0.0030901292338967323,
-0.005015265662223101,
0.07562410086393356,
-0.11101066321134567,
0.11101267486810684,
-0.07704753428697586,
0.15423661470413208,
-0.0037991832941770554,
-0.26816508173942566,
0.07709614187479019,
0.02366705611348152,
-0.06558974832296371,
0.018053114414215088,
0.07005557417869568,
-0.11915943771600723,
-0.014769842848181725,
-0.08780970424413681,
-0.04377039149403572,
0.11009286344051361,
0.05467013269662857,
-0.018932325765490532,
0.11158192157745361,
-0.0877915695309639,
-0.1445721685886383,
-0.07380212843418121,
-0.04699331149458885,
-0.17613957822322845,
-0.13904547691345215,
0.08200705796480179,
-0.022013088688254356,
-0.06083914265036583,
-0.11042837798595428,
0.14598232507705688,
-0.03723303601145744,
-0.015534439124166965,
-0.1376170665025711,
0.14061692357063293,
0.04878004267811775,
0.14093522727489471,
0.01829737052321434,
-0.025070451200008392,
-0.01008773036301136,
0.026213593780994415,
0.08805182576179504,
-0.06845324486494064,
-0.07777898758649826,
-0.14859896898269653,
0.14769071340560913,
0.12763075530529022,
0.020912375301122665,
-0.18202878534793854,
-0.016733910888433456,
-0.007492888253182173,
-0.22210922837257385,
0.08983664214611053,
-0.025035731494426727,
-0.07233981043100357,
0.06666137278079987,
0.08735912293195724,
0.046394430100917816,
-0.32709240913391113,
0.09786124527454376,
-0.060930997133255005,
0.22752514481544495,
-0.22255931794643402,
0.0013100594514980912,
-0.04042758420109749,
0.30653116106987,
0.08274271339178085,
0.06184331700205803,
-0.11382266134023666,
0.04545445367693901,
-0.13944363594055176,
0.15232567489147186,
0.11967881768941879,
-0.036736633628606796,
-0.1719837784767151,
-0.12968474626541138,
0.014107142575085163,
0.0012013200903311372,
-0.006517520174384117,
0.05539051070809364,
-0.07871599495410919,
-0.0577087439596653,
0.048843927681446075,
-0.01181783340871334,
-0.08139877766370773,
-0.022307751700282097,
0.10502471774816513,
-0.1445416808128357,
0.15073736011981964,
0.10998351126909256,
-0.05836642161011696,
0.008415594696998596,
0.06591862440109253,
-0.02213137038052082,
0.16326910257339478,
-0.09124624729156494,
0.09533406794071198,
-0.05386876314878464,
0.07457557320594788,
-0.02315082773566246,
-0.08832230418920517,
-0.009187844581902027,
0.22040382027626038,
-0.11764262616634369,
0.14490877091884613,
-0.019139453768730164,
0.02079441025853157,
0.07075604796409607,
0.0666978508234024,
0.058035869151353836,
-0.11897215247154236,
-0.04097092151641846,
-0.010658425278961658,
-0.10891364514827728,
0.09231239557266235,
-0.0035848633851855993,
-0.018041010946035385,
0.02171657606959343,
0.06838608533143997,
0.08673036843538284,
0.012320569716393948,
0.174848273396492,
0.01479955855756998,
-0.07343865931034088,
0.022026246413588524,
-0.08657001703977585,
0.11839645355939865,
-0.16349413990974426,
0.08909513056278229,
-0.08852371573448181,
0.06418202817440033,
0.04428863152861595,
-0.17564673721790314,
-0.019534481689333916,
-0.1659965068101883,
-0.017155002802610397,
0.03205377236008644,
0.03920884057879448,
0.10980518162250519,
0.14322644472122192,
0.155075803399086,
0.013252126052975655,
-0.08008988946676254,
0.049821190536022186,
0.05059634521603584,
-0.08036365360021591,
0.08891796320676804,
0.27450892329216003,
0.10185521095991135,
-0.12702766060829163,
-0.15576501190662384,
0.10812823474407196,
-0.07616699486970901,
0.07175511866807938,
0.13110417127609253,
-0.1426541656255722,
-0.00026998735847882926,
0.20963971316814423,
-0.08699993789196014,
-0.10844135284423828,
-0.14484284818172455,
-0.1259855479001999,
-0.02270043082535267,
-0.03573636710643768,
0.03791295364499092,
0.053626883774995804,
0.17756710946559906,
-0.017205417156219482,
-0.0042424811981618404,
-0.02572828345000744,
0.05482969805598259,
-0.0055108442902565,
0.017236066982150078,
0.05026686564087868,
-0.17580871284008026,
0.07923968136310577,
0.0437028668820858,
-0.23817984759807587,
0.18705789744853973,
0.20522873103618622,
-0.06253717094659805,
-0.02574675716459751,
0.014601405709981918,
-0.061148058623075485,
0.12608791887760162,
-0.07561303675174713,
0.06790151447057724,
0.04968249797821045,
0.07258187979459763,
0.09837768971920013,
0.06440408527851105,
0.05692465975880623,
-0.0013334876857697964,
0.050997041165828705,
-0.03303098306059837,
0.1127934604883194,
-0.03207150846719742,
-0.010503115132451057,
-0.0890161469578743,
-0.154591366648674,
-0.05515141040086746,
0.12522634863853455,
0.10114127397537231,
-0.01469523087143898,
0.023551233112812042,
-0.0931670293211937,
0.06410449743270874,
-0.01371187437325716,
-0.19146056473255157,
0.08859337121248245,
0.01922105997800827,
-0.12273897230625153,
-0.009056681767106056,
-0.02896343357861042,
-0.020534634590148926,
-0.018969036638736725,
-0.03170635923743248,
-0.04907567799091339,
0.017782015725970268
] |
orphanet | https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99657 | Q4DAqj3 | Primary dystonia, DYT2 type | C1857093 | 31,759 | primary dystonia, dyt2 type. Primary dystonia DYT2 type is characterized by segmental dystonia that manifests with involuntary posturing affecting predominantly the feet.
Epidemiology
The exact prevalence is unknown. The disease is reported in a limited number of Jewish and Gypsy families.
Clinical description
The onset of the symptoms is early in childhood or adolescence. Progression to generalized dystonia is possible.
Genetic counseling
The DYT2 locus is unknown. Autosomal recessive transmission is suggested. | [
-0.03748225048184395,
0.17009951174259186,
-0.020695945248007774,
0.045645248144865036,
-0.08084611594676971,
-0.18436169624328613,
-0.041327495127916336,
0.10145974159240723,
-0.19253350794315338,
0.19294431805610657,
-0.07106034457683563,
0.23219440877437592,
0.042474471032619476,
0.19231688976287842,
-0.06470919400453568,
-0.02085442654788494,
0.1696787327528,
0.17419151961803436,
-0.05309747904539108,
-0.03430750593543053,
-0.09211769700050354,
-0.2430344671010971,
0.010345125570893288,
0.09259139001369476,
0.22055743634700775,
-0.18002949655056,
0.11169015616178513,
-0.054608989506959915,
0.08759865909814835,
0.2739521265029907,
0.12439248710870743,
0.07358686625957489,
-0.21497522294521332,
-0.0831933468580246,
0.15238726139068604,
0.1200360655784607,
0.011345651932060719,
0.14100192487239838,
0.09773384779691696,
-0.21959981322288513,
0.12025915086269379,
0.17270256578922272,
0.08792411535978317,
0.08901026099920273,
-0.047895267605781555,
0.036914970725774765,
0.132971853017807,
0.0023007001727819443,
0.008789028972387314,
-0.005157508887350559,
0.19931918382644653,
0.2038489431142807,
-0.019465159624814987,
-0.05808860436081886,
0.17758895456790924,
0.0031353901140391827,
-0.1230524554848671,
0.007239204831421375,
-0.3427479565143585,
0.07645101100206375,
-0.03931500017642975,
-0.15980112552642822,
-0.13694363832473755,
-0.24564070999622345,
0.2546818256378174,
-0.014954175800085068,
0.13917838037014008,
-0.09590248763561249,
0.20961084961891174,
-0.11638788133859634,
0.15792420506477356,
-0.278491735458374,
-0.15612953901290894,
-0.055468712002038956,
-0.3922201693058014,
-0.1428104043006897,
0.06192225590348244,
0.17373880743980408,
-0.2608867585659027,
-0.519773006439209,
-0.03616746515035629,
0.08165603876113892,
0.07168252021074295,
0.07357661426067352,
0.19304603338241577,
0.1335383653640747,
0.15171538293361664,
0.07603185623884201,
-0.24265387654304504,
0.45321547985076904,
0.26131671667099,
-0.06695771962404251,
0.024025162681937218,
-0.30383244156837463,
0.12202271819114685,
0.00035705132177099586,
0.07335012406110764,
-0.03728833422064781,
-0.2805689871311188,
-0.03837544471025467,
-0.035891372710466385,
0.07441204786300659,
0.2800455391407013,
0.1023588553071022,
0.20807789266109467,
-0.004979202523827553,
-0.12485227733850479,
-0.024727245792746544,
-0.1721147745847702,
0.08591046929359436,
-0.05119682848453522,
0.06632950156927109,
-0.3148971199989319,
-0.170882910490036,
-0.192783385515213,
0.14541742205619812,
0.32001614570617676,
0.27173224091529846,
-0.34581050276756287,
-0.20220519602298737,
0.20305079221725464,
-0.2156415581703186,
0.16146425902843475,
0.16787485778331757,
0.03889188542962074,
0.018665015697479248,
0.2879655063152313,
-0.16835585236549377,
0.3331120014190674,
0.02627832069993019,
0.17360366880893707,
0.160787433385849,
-0.1673501878976822,
-0.30459657311439514,
-0.07518259435892105,
-0.09785447269678116,
-0.13619844615459442,
-0.15426068007946014,
-0.29002615809440613,
0.04496636241674423,
-0.10828809440135956,
0.27146780490875244,
0.15736518800258636,
0.3125113248825073,
0.02417699433863163,
0.0005060640978626907,
0.31362858414649963,
0.05687868595123291,
0.3071189224720001,
0.18765458464622498,
0.2508525848388672,
-0.0013593838084489107,
0.4335218667984009,
0.008664441294968128,
0.4251886308193207,
-0.09229118376970291,
0.17337583005428314,
0.2411005198955536,
-0.3496367931365967,
0.09176592528820038,
-0.02000417932868004,
-0.2531180679798126,
0.048253532499074936,
-0.24212810397148132,
-0.08046093583106995,
-0.13865111768245697,
0.17600880563259125,
-0.08935273438692093,
0.24162591993808746,
0.17518791556358337,
-0.19000625610351562,
0.0683433786034584,
-0.31781113147735596,
-0.041169196367263794,
0.024614674970507622,
0.1338663250207901,
-0.1409953236579895,
-0.004392213188111782,
-0.16020797193050385,
0.20394887030124664,
-0.015229586511850357,
0.02122834511101246,
0.030242878943681717,
-0.12266728281974792,
0.12042288482189178,
-0.016449743881821632,
0.20866639912128448,
0.07144662737846375,
-0.09867285937070847,
0.33135753870010376,
0.01206275075674057,
0.029035694897174835,
-0.19012656807899475,
0.258348673582077,
-0.14814762771129608,
-0.2946292459964752,
0.032033782452344894,
0.12889549136161804,
-0.05774123594164848,
-0.14224083721637726,
-0.16326919198036194,
-0.21164512634277344,
0.0942811444401741,
0.22896987199783325,
0.07443119585514069,
-0.08011201024055481,
0.014552800916135311,
0.0008864428964443505,
0.05233775079250336,
0.22600792348384857,
0.04599769040942192,
0.29859739542007446,
-0.12933626770973206,
-0.16563336551189423,
0.16235509514808655,
-0.01320931687951088,
-0.00035515648778527975,
0.10027830302715302,
-0.2182973474264145,
0.11803165078163147,
-0.2713029980659485,
-0.16722147166728973,
-0.5810844302177429,
-0.3076969087123871,
-0.0071478611789643764,
0.00009659174975240603,
-0.21960954368114471,
0.1274285614490509,
-0.178610160946846,
0.0676112100481987,
-0.22284790873527527,
0.10395119339227676,
0.07662518322467804,
-0.0840018093585968,
-0.06441684067249298,
-0.285560667514801,
0.1824805736541748,
-0.08212076127529144,
0.5091803669929504,
-0.19902214407920837,
-0.299089640378952,
0.041122645139694214,
-0.07693176716566086,
0.10353593528270721,
0.1351930797100067,
-0.02254660055041313,
0.13235847651958466,
0.14445917308330536,
-0.22123953700065613,
-0.03873980790376663,
0.2634231746196747,
0.04920453205704689,
0.22919277846813202,
0.04030734300613403,
-0.3373844623565674,
-0.03547079116106033,
-0.02609468251466751,
0.014158305712044239,
0.371056467294693,
-0.10243839025497437,
0.08466627448797226,
0.2516632378101349,
-0.10127424448728561,
-0.15610076487064362,
0.13389846682548523,
0.0663246363401413,
-0.38908320665359497,
-0.20744457840919495,
0.05521189793944359,
-0.23652082681655884,
-0.2969023883342743,
0.17859932780265808,
0.21900887787342072,
0.15529969334602356,
-0.0830855518579483,
0.1025649905204773,
-0.04715913161635399,
0.13761258125305176,
0.07724872976541519,
-0.11336714774370193,
-0.25374481081962585,
-0.1314881443977356,
-0.11351197212934494,
-0.17668254673480988,
0.3560880720615387,
-0.32530850172042847,
0.07785075157880783,
-0.23889067769050598,
-0.14521947503089905,
-0.004414750728756189,
-0.07935453951358795,
-0.07140781730413437,
-0.15772536396980286,
-0.14661918580532074,
0.18361161649227142,
0.07192052155733109,
0.24033042788505554,
0.21906886994838715,
0.17222918570041656,
0.14915938675403595,
0.162668839097023,
0.10260708630084991,
0.11177398264408112,
0.1694382131099701,
0.02384999208152294,
0.040847256779670715,
0.2953474819660187,
0.08774997293949127,
-0.21916839480400085,
-0.15146121382713318,
-0.3916708528995514,
0.10304958373308182,
-0.21109195053577423,
-0.03845558315515518,
0.14968232810497284,
-0.15670503675937653,
-0.32518571615219116,
0.09282659739255905,
0.17519356310367584,
0.3170008361339569,
-0.07136829197406769,
-0.08528381586074829,
-0.1222863495349884,
0.2527240812778473,
-0.44840991497039795,
-0.059600722044706345,
0.1523781567811966,
0.0197211354970932,
-0.18548837304115295,
0.0811137706041336,
0.148609921336174,
0.2510017156600952,
-0.15642483532428741,
-0.14662982523441315,
-0.02977035380899906,
-0.03509604558348656,
0.2373284548521042,
-0.2119860053062439,
-0.032836463302373886,
0.15488098561763763,
0.007912427186965942,
-0.46691757440567017,
-0.05217629671096802,
-0.16087649762630463,
-0.19397220015525818,
-0.1190972551703453,
-0.10621285438537598,
0.05529337748885155,
0.27665773034095764,
0.0793231725692749,
0.0710332915186882,
-0.15124401450157166,
-0.09714411199092865,
0.045706745237112045,
0.2661564350128174,
0.0007180654793046415,
-0.016106417402625084,
-0.08848121017217636,
0.05164232477545738,
-0.13697627186775208,
-0.012449837289750576,
-0.25515857338905334,
0.2263435423374176,
0.046710919588804245,
-0.0344335176050663,
-0.11376865953207016,
0.1736467033624649,
0.4156879186630249,
0.2839587926864624,
-0.04910498857498169,
-0.006822898052632809,
-0.4102196991443634,
-0.026380855590105057,
0.2795732021331787,
0.2012728750705719,
0.13144442439079285,
-0.1711059808731079,
-0.15784181654453278,
-0.2817252576351166,
-0.34864339232444763,
0.07577408105134964,
-0.04295269027352333,
-0.09408313781023026,
0.024323390796780586,
-0.32353806495666504,
0.1734990030527115,
-0.15774767100811005,
0.1613614708185196,
0.09940788149833679,
-0.0004213953507132828,
0.3729710280895233,
-0.0461147241294384,
-0.29523760080337524,
0.024496380239725113,
-0.11148735880851746,
-0.08921454101800919,
0.09059784561395645,
-0.1096533015370369,
-0.20193356275558472,
0.18682841956615448,
-0.21745122969150543,
0.015123898163437843,
0.0809675008058548,
0.08687762171030045,
0.03082440234720707,
0.1120985597372055,
0.27021151781082153,
0.19915635883808136,
0.19094540178775787,
-0.027145499363541603,
-0.02230856567621231,
0.09856622666120529,
0.16048389673233032,
-0.1632501780986786,
-0.07835566252470016,
-0.13325604796409607,
0.12870673835277557,
-0.29911699891090393,
-0.07608138769865036,
-0.14769408106803894,
-0.10493087768554688,
-0.0909801572561264,
0.09988125413656235,
0.0944300964474678,
0.13665413856506348,
-0.31474927067756653,
-0.03543915972113609,
-0.24893143773078918,
0.20390096306800842,
0.18358950316905975,
0.3201831877231598,
0.15489450097084045,
-0.6515170335769653,
-0.102665014564991,
0.00901109166443348,
0.14341279864311218,
0.11824116855859756,
0.18261538445949554,
-0.02101648785173893,
0.12411237508058548,
0.2607576251029968,
0.02448735572397709,
-0.06579354405403137,
-0.3151742219924927,
0.042306505143642426,
0.007512348238378763,
0.14796718955039978,
-0.430791974067688,
0.15606333315372467,
-0.07308247685432434,
-0.15002359449863434,
0.025972602888941765,
-0.027628853917121887,
0.16406576335430145,
-0.13572490215301514,
-0.14266899228096008,
0.08998435735702515,
-0.017410818487405777,
-0.04730972647666931,
-0.00016658044478390366,
0.3874627351760864,
0.11825571954250336,
-0.017352748662233353,
-0.24916306138038635,
-0.00846559926867485,
-0.13445530831813812,
-0.20518489181995392,
0.08819878101348877,
0.0985204353928566,
-0.12433227896690369,
0.05466790869832039,
0.20562288165092468,
-0.12490760535001755,
-0.11288365721702576,
0.07474028319120407,
-0.005291176959872246,
-0.10555154085159302,
-0.40398329496383667,
-0.024326417595148087,
-0.3452984690666199,
0.027012795209884644,
-0.10547031462192535,
-0.06437914073467255,
0.1935649812221527,
0.03582864627242088,
-0.11726618558168411,
0.02746901661157608,
0.10553532838821411,
0.248491108417511,
-0.11077511310577393,
-0.1353088915348053,
0.1619129180908203,
-0.02099563740193844,
0.158844992518425,
-0.10487222671508789,
-0.18854044377803802,
-0.12956181168556213,
-0.1581622064113617,
-0.2889055907726288,
-0.2337450534105301,
0.09496207535266876,
-0.008334985934197903,
0.19981728494167328,
0.10168958455324173,
-0.07087761163711548,
-0.15530499815940857,
0.03940990939736366,
-0.2582629919052124,
0.10473727434873581,
0.2904488146305084,
0.010970602743327618,
-0.05233944579958916,
-0.007070546504110098,
-0.20461417734622955,
0.12941862642765045,
-0.12588335573673248,
0.01730155013501644,
0.22659438848495483,
-0.15599417686462402,
-0.03056090697646141,
0.04897206649184227,
-0.0893588587641716,
0.1322324126958847,
0.06943588703870773,
0.2210257202386856,
-0.18415343761444092,
0.16668780148029327,
-0.008948588743805885,
0.19608421623706818,
-0.3179950416088104,
-0.2770960330963135,
-0.007921427488327026,
-0.01752689853310585,
-0.13357971608638763,
0.20977522432804108,
0.18223880231380463,
-0.145829975605011,
-0.010877285152673721,
-0.03579263016581535,
-0.3122115433216095,
-0.3425443470478058,
0.0267596784979105,
-0.0909799262881279,
0.008464401587843895,
0.1722138226032257,
-0.20639990270137787,
0.11366795748472214,
-0.039055392146110535,
0.045142535120248795,
0.010817731730639935,
-0.0674896314740181,
-0.08914999663829803,
-0.05403834208846092,
-0.07750511914491653,
-0.3198176920413971,
-0.19961108267307281,
0.1163371354341507,
0.029742369428277016,
0.12042205780744553,
0.07249385863542557,
-0.13177843391895294,
0.043049536645412445,
-0.319561243057251,
0.15526588261127472,
0.12297897785902023,
0.0031633961480110884,
0.25920289754867554,
-0.023887434974312782,
0.03220207616686821,
-0.00045205705100670457,
-0.305493026971817,
0.23542335629463196,
-0.06632690876722336,
-0.034380827099084854,
-0.310152143239975,
-0.02401117794215679,
-0.5222067832946777,
-0.19055494666099548,
-0.053855568170547485,
0.1977721005678177,
-0.08749085664749146,
-0.2352025806903839,
-0.07258101552724838,
-0.020477844402194023,
-0.05546494200825691,
0.19021010398864746,
-0.009959599003195763,
0.1896010935306549,
0.1341983526945114,
0.07019609212875366,
-0.1468629091978073,
-0.28045782446861267,
-0.17730456590652466,
-0.025015657767653465,
0.22457347810268402,
-0.1145290955901146,
0.07472369074821472,
0.019783029332756996,
0.04099616780877113,
-0.053801681846380234,
-0.09886354207992554,
0.029521651566028595,
-0.11896676570177078,
0.016476009041070938,
0.1802976131439209,
-0.017470525577664375,
0.10694096982479095,
-0.34431686997413635,
-0.04730089381337166,
-0.27838972210884094,
0.16255609691143036,
0.09215748310089111,
0.06998345255851746,
0.021743109449744225,
0.1305866837501526,
0.06020231544971466,
-0.15474040806293488,
-0.1485932171344757,
0.1100630834698677,
-0.18782980740070343,
0.322568416595459,
0.10768317431211472,
-0.13459330797195435,
-0.23701998591423035,
-0.17561638355255127,
0.09350445121526718,
-0.15668754279613495,
-0.16041848063468933,
0.04366612061858177,
0.09303589165210724,
-0.15654517710208893,
0.08151715993881226,
0.3099854588508606,
-0.042278822511434555,
0.22717736661434174,
0.4298582077026367,
0.04316520690917969,
0.04089749976992607,
-0.011758710257709026,
-0.1449161171913147,
-0.11282956600189209,
0.2537783086299896,
-0.23606698215007782,
0.34312447905540466,
-0.26734456419944763,
0.27420341968536377,
-0.05712504684925079,
-0.2835335433483124,
-0.2044869363307953,
-0.0659012645483017,
-0.15055255591869354,
0.10897621512413025,
0.1071445420384407,
0.07652890682220459,
0.11051511019468307,
-0.18866083025932312,
0.33989423513412476,
-0.12089503556489944,
0.28983238339424133,
0.1010930985212326,
0.05132673308253288,
-0.3330342471599579,
0.026108575984835625,
0.023387368768453598,
-0.1648474931716919,
-0.08417213708162308,
-0.03365736082196236,
0.06510964035987854,
0.09962025284767151,
-0.4237372875213623,
-0.017965205013751984,
0.07480938732624054,
-0.002589254407212138,
-0.03482493758201599,
0.1611114889383316,
0.01587882824242115,
0.16330774128437042,
-0.18022465705871582,
0.01873352937400341,
0.16496798396110535,
-0.22109636664390564,
-0.2773462235927582,
-0.037324581295251846,
-0.2355140745639801,
0.0785752534866333,
0.2131255716085434,
0.05563246086239815,
-0.0127658536657691,
0.1356678456068039,
0.11068520694971085,
0.03918924182653427,
-0.20887260138988495,
0.2848440110683441,
0.22498497366905212,
-0.0884355753660202,
-0.09240969270467758,
0.3182325065135956,
0.43542736768722534,
-0.1096685454249382,
-0.2979515492916107,
0.04556053504347801,
0.035344429314136505,
-0.037576138973236084,
0.08294982463121414,
-0.08735137432813644,
-0.09749903529882431,
-0.2780381739139557,
0.05158398300409317,
-0.1641213744878769,
-0.11571802198886871,
0.020117368549108505,
-0.03918362781405449,
-0.26384660601615906,
0.306200236082077,
0.04557549208402634,
0.0014268693048506975,
-0.24528303742408752,
-0.1832890808582306,
-0.16914725303649902,
-0.32254961133003235,
0.018722373992204666,
-0.07402649521827698,
0.15857219696044922,
-0.0629102811217308,
0.051875121891498566,
0.15256714820861816,
-0.10863932222127914,
0.3648134469985962,
0.43946734070777893,
-0.04520704969763756,
-0.19426079094409943,
-0.10437559336423874,
-0.2138296663761139,
0.016336649656295776,
-0.08996104449033737,
-0.18263310194015503,
0.07328470051288605,
-0.025828775018453598,
-0.040134917944669724,
-0.2854088544845581,
-0.04533051326870918,
-0.08501212298870087,
0.12748852372169495,
-0.1776457279920578,
0.2793352007865906,
-0.07399433106184006,
-0.059646330773830414,
-0.025270042940974236,
-0.15301354229450226,
0.1386127769947052,
0.011675048619508743,
-0.20588845014572144,
0.29018518328666687,
0.15803545713424683,
0.00042266398668289185,
-0.01912572979927063,
-0.12974920868873596,
-0.30909767746925354,
-0.06236698105931282,
-0.04279370233416557,
-0.3073233366012573,
-0.08620386570692062,
0.0636909231543541,
0.032808300107717514,
-0.14435341954231262,
-0.3623930513858795,
0.2006044238805771,
-0.024096418172121048
] |
omim | https://www.omim.org/entry/251945 | O0gYNLn | MITOCHONDRIAL MYOPATHY WITH A DEFECT IN MITOCHONDRIAL-PROTEIN TRANSPORT | C1855034 | 31,760 | mitochondrial myopathy with a defect in mitochondrial-protein transport. Schapira et al. (1990) described the 14-year-old daughter of an English father and Chinese mother who had had muscle weakness and exercise intolerance since early infancy. Fetal movements had been reduced during pregnancy. There were no clinical manifestations related to systems other than skeletal muscle. Deficiency of respiratory-chain Complexes I to IV was found. Mitochondrial preparations showed specific deficiencies of both the iron-sulfur protein of Complex III ('Rieske' protein) and the 27.2-kD subunit of succinate dehydrogenase. Similar experiments with muscle homogenates indicated a deficiency of the subunit of succinate dehydrogenase, but normal levels of the precursor Rieske protein. The findings were interpreted as indicating a defect in the transport of the Rieske protein into mitochondria. Schapira et al. (1990) speculated that some iron-sulfur proteins of the mitochondrial respiratory chain may be encoded by a cluster of nuclear genes and that a mutation affecting a single | [
-0.19380415976047516,
0.07194233685731888,
0.3981625735759735,
-0.15095125138759613,
0.11796876788139343,
0.08890431374311447,
-0.18942968547344208,
-0.17525814473628998,
-0.18909232318401337,
0.1110427975654602,
0.1590973436832428,
-0.3392871618270874,
-0.08302303403615952,
0.030830956995487213,
0.22543199360370636,
0.05394129455089569,
0.0922594666481018,
-0.2260340005159378,
-0.004810330457985401,
-0.03725455328822136,
-0.3449620008468628,
0.07426407188177109,
-0.10436566174030304,
0.48335912823677063,
0.025771908462047577,
-0.0014410463627427816,
-0.1830189824104309,
0.17455609142780304,
-0.04272115230560303,
0.17943954467773438,
-0.1718505173921585,
-0.027564426884055138,
0.2002696990966797,
0.05153108015656471,
-0.09750235080718994,
-0.31881165504455566,
-0.2856465280056,
-0.03620210662484169,
-0.08630459010601044,
0.0983799621462822,
-0.34825223684310913,
-0.07815113663673401,
-0.08948183804750443,
-0.30266401171684265,
0.20209147036075592,
0.16181860864162445,
0.08923780918121338,
-0.23371022939682007,
-0.16115476191043854,
0.2980440557003021,
-0.013452162966132164,
0.1842469424009323,
0.26570016145706177,
-0.2299463450908661,
0.33354368805885315,
-0.11301331967115402,
-0.06551574170589447,
0.18947026133537292,
-0.08449596911668777,
-0.25432488322257996,
-0.18903903663158417,
0.19817794859409332,
-0.08518077433109283,
-0.10671549290418625,
-0.2011861503124237,
-0.21403560042381287,
-0.10357770323753357,
0.17008854448795319,
0.29103976488113403,
0.03133029490709305,
0.08749821782112122,
-0.04332498833537102,
0.45602500438690186,
0.20669102668762207,
0.15839388966560364,
-0.20745165646076202,
-0.125418558716774,
-0.10218637436628342,
-0.07098646461963654,
-0.01345314271748066,
-0.16469091176986694,
0.07424522191286087,
-0.13469673693180084,
0.1690855175256729,
-0.017616212368011475,
0.12516994774341583,
-0.14383244514465332,
0.2499263435602188,
0.03459841385483742,
0.09656679630279541,
0.33199048042297363,
-0.03190666437149048,
0.005065798759460449,
-0.17862509191036224,
0.10788086801767349,
-0.15076026320457458,
0.4516180455684662,
-0.18802088499069214,
-0.06408876925706863,
0.12344584614038467,
0.07333721965551376,
0.018462175503373146,
-0.06279391050338745,
0.18022391200065613,
0.09952466189861298,
-0.062115076929330826,
-0.1503589153289795,
0.026962079107761383,
-0.15098880231380463,
-0.07845408469438553,
0.2723255753517151,
0.11133497953414917,
-0.19522154331207275,
0.002038323087617755,
-0.4093394875526428,
0.10620395094156265,
0.23917627334594727,
0.011805307120084763,
-0.14875979721546173,
0.13980095088481903,
-0.3390544056892395,
0.08251197636127472,
0.3480451703071594,
0.10488996654748917,
0.30112749338150024,
0.19928939640522003,
0.17853285372257233,
0.033204931765794754,
0.39166325330734253,
-0.17929404973983765,
-0.21324720978736877,
-0.3772225081920624,
-0.3662351071834564,
0.4312746822834015,
-0.046949602663517,
0.09547368437051773,
-0.23849979043006897,
-0.14745312929153442,
0.022563045844435692,
0.05840378627181053,
-0.02668008580803871,
0.03809208422899246,
-0.056302256882190704,
0.1926303207874298,
-0.24605482816696167,
0.2987854778766632,
0.13575021922588348,
-0.28430381417274475,
0.19516712427139282,
0.0716024786233902,
0.21154846251010895,
-0.2950519621372223,
0.0915655791759491,
-0.235957533121109,
-0.029226595535874367,
0.25045353174209595,
0.0953601598739624,
-0.09941013902425766,
0.028211727738380432,
-0.05091377720236778,
-0.029502227902412415,
-0.009516455233097076,
-0.08886712044477463,
-0.28259849548339844,
-0.46720123291015625,
-0.2444273829460144,
-0.08379638940095901,
0.2597849369049072,
0.2640136182308197,
-0.20548604428768158,
-0.22048301994800568,
-0.004147977102547884,
-0.11946762353181839,
0.3075214922428131,
0.2707117199897766,
-0.07153160125017166,
0.0053733051754534245,
-0.0596824511885643,
0.008815121836960316,
0.19368551671504974,
0.1380089670419693,
-0.3109859526157379,
-0.1783534437417984,
0.25095343589782715,
0.15144428610801697,
-0.2941741943359375,
0.23634859919548035,
0.15955041348934174,
-0.17309340834617615,
-0.012783283367753029,
0.421652227640152,
-0.06488930433988571,
-0.13437339663505554,
-0.05168607085943222,
-0.6997664570808411,
-0.07720977813005447,
-0.02860129065811634,
-0.24340471625328064,
0.1340607851743698,
-0.006753035355359316,
0.31160226464271545,
-0.14157964289188385,
0.1606048345565796,
-0.0461268313229084,
-0.040907155722379684,
0.227373406291008,
0.1427239626646042,
-0.044480904936790466,
0.16277682781219482,
0.08215317875146866,
-0.022508971393108368,
0.24796132743358612,
-0.2782845199108124,
0.14187003672122955,
-0.06952839344739914,
0.23871959745883942,
-0.005086046643555164,
0.06408531963825226,
-0.1248612329363823,
0.07697456330060959,
-0.10163766890764236,
0.09585558623075485,
0.24126729369163513,
-0.25997933745384216,
-0.17221935093402863,
0.1639484018087387,
-0.10955895483493805,
-0.05131048336625099,
-0.02669384330511093,
-0.08806519955396652,
0.2344592958688736,
-0.011822996661067009,
0.10035692155361176,
-0.09063120186328888,
0.007429605815559626,
-0.1021854355931282,
0.15036828815937042,
0.026014111936092377,
-0.17084449529647827,
-0.009433983825147152,
-0.30304014682769775,
-0.11215310543775558,
-0.2675108015537262,
0.1371176689863205,
0.17544348537921906,
-0.12598970532417297,
0.14601168036460876,
0.2099645584821701,
0.26679790019989014,
0.13541845977306366,
-0.007188116665929556,
-0.1504492163658142,
0.22009392082691193,
-0.14311440289020538,
-0.3757600486278534,
-0.10389336943626404,
-0.023273630067706108,
-0.187820702791214,
-0.17389963567256927,
0.41802120208740234,
0.296562135219574,
0.12841308116912842,
-0.06238381192088127,
0.3961571156978607,
-0.3530251383781433,
-0.18402007222175598,
-0.03944976627826691,
0.16345107555389404,
0.0049021379090845585,
-0.0653468519449234,
-0.10338599979877472,
-0.045400675386190414,
0.4444950520992279,
-0.11303771287202835,
-0.16705437004566193,
-0.012302471324801445,
-0.12350412458181381,
0.15690389275550842,
0.2975176274776459,
-0.07531655579805374,
-0.24891069531440735,
0.24463388323783875,
0.018663713708519936,
-0.016140861436724663,
0.326209157705307,
-0.24267049133777618,
0.20210248231887817,
0.08047152310609818,
-0.541670560836792,
0.0435086227953434,
-0.22936508059501648,
-0.009114192798733711,
-0.2922658920288086,
0.1985442340373993,
0.22761869430541992,
-0.041759345680475235,
0.0922253206372261,
0.043494585901498795,
0.27537810802459717,
-0.13763770461082458,
0.036665793508291245,
0.24362924695014954,
0.09737536311149597,
-0.03337160125374794,
-0.42748382687568665,
0.17743034660816193,
0.020416373386979103,
0.013630290515720844,
-0.025492915883660316,
0.1527332216501236,
-0.6709959506988525,
-0.005576946772634983,
-0.00832833256572485,
0.18043212592601776,
-0.37543293833732605,
0.013851098716259003,
-0.061268411576747894,
0.0324065200984478,
-0.04460085928440094,
-0.04724038764834404,
-0.09425827115774155,
0.03788091987371445,
-0.08285824209451675,
0.10056397318840027,
0.037245605140924454,
0.08920536935329437,
-0.15125344693660736,
0.20056404173374176,
-0.20848308503627777,
-0.029430868104100227,
0.129807710647583,
0.10236233472824097,
0.06026181951165199,
0.011884093284606934,
-0.03637036681175232,
-0.021688971668481827,
0.2575082778930664,
0.09573749452829361,
-0.4011043310165405,
-0.4520980715751648,
0.1618824601173401,
-0.3345595598220825,
-0.11758924275636673,
-0.3828546702861786,
0.13838885724544525,
0.19177934527397156,
-0.07359209656715393,
0.408597856760025,
0.15455247461795807,
-0.0629279688000679,
-0.24694763123989105,
0.25570788979530334,
0.0847645029425621,
-0.2818816006183624,
0.14393839240074158,
-0.19266392290592194,
0.055480681359767914,
0.4997446537017822,
0.04686736315488815,
-0.16592003405094147,
-0.14280322194099426,
0.016003495082259178,
0.17047704756259918,
-0.029551537707448006,
0.061448097229003906,
-0.12847892940044403,
0.16441823542118073,
0.07247849553823471,
0.1585991531610489,
0.11765114217996597,
-0.16088402271270752,
-0.08391992747783661,
-0.0794987753033638,
-0.03900502622127533,
-0.3516707420349121,
-0.13706038892269135,
0.033780619502067566,
0.05156306177377701,
-0.00897484552115202,
-0.030636068433523178,
-0.1563495248556137,
0.14926154911518097,
-0.038696058094501495,
0.359943687915802,
-0.00965710636228323,
0.3094923496246338,
-0.028632594272494316,
0.12691007554531097,
0.07052816450595856,
-0.01889689639210701,
-0.32660990953445435,
0.17937369644641876,
-0.07887690514326096,
0.06174831464886665,
0.21072563529014587,
0.21268723905086517,
-0.11741290986537933,
0.11309913545846939,
-0.12571582198143005,
0.03422665223479271,
-0.029262183234095573,
-0.4090330898761749,
0.2990986704826355,
-0.06478624790906906,
0.13145992159843445,
0.1464925855398178,
0.2404446303844452,
0.046383123844861984,
-0.34794676303863525,
-0.07007136940956116,
-0.2686346471309662,
-0.2609114348888397,
0.05101179704070091,
0.0354611910879612,
-0.28279125690460205,
0.005988664925098419,
0.36897188425064087,
0.2310929298400879,
-0.08353569358587265,
0.1570916324853897,
-0.11905614286661148,
-0.16867144405841827,
0.4923807978630066,
-0.08795932680368423,
0.15358057618141174,
0.09676022827625275,
0.15084823966026306,
0.023151474073529243,
0.009938742965459824,
-0.09761404991149902,
0.14715512096881866,
-0.18281280994415283,
0.056399811059236526,
-0.19452576339244843,
0.284129798412323,
0.20096756517887115,
-0.017772462218999863,
0.1588711142539978,
-0.06942835450172424,
-0.047632697969675064,
0.23674651980400085,
-0.05479097738862038,
0.2637118995189667,
-0.14992903172969818,
-0.06009227782487869,
0.25883474946022034,
-0.03911718353629112,
0.21006324887275696,
-0.09349791705608368,
-0.06462959945201874,
-0.0014062562258914113,
0.018104946240782738,
0.3187110126018524,
-0.12851206958293915,
-0.18690453469753265,
0.05944254994392395,
-0.006947665475308895,
-0.1211252436041832,
-0.0013190400786697865,
-0.3316253423690796,
0.16265815496444702,
0.04989971965551376,
0.1867789775133133,
-0.21057794988155365,
-0.03092426247894764,
0.5765684247016907,
-0.28669100999832153,
-0.11671554297208786,
0.1412932127714157,
0.10132100433111191,
0.05720174312591553,
0.05780604109168053,
0.14271216094493866,
0.08389607071876526,
0.18355461955070496,
-0.007435365114361048,
-0.05820385366678238,
-0.0528416782617569,
-0.03527701273560524,
0.08876696228981018,
-0.038506679236888885,
-0.0564718097448349,
-0.23753665387630463,
0.06092534959316254,
0.14762504398822784,
0.0903889387845993,
0.016528969630599022,
-0.21149615943431854,
0.2799883782863617,
0.07764498889446259,
-0.0016060629859566689,
-0.0940646305680275,
-0.17849259078502655,
0.33945319056510925,
0.05270734429359436,
0.03378898277878761,
-0.05724911391735077,
0.01995689794421196,
0.07735949754714966,
0.16188178956508636,
0.07526472210884094,
-0.3055116534233093,
0.09283056110143661,
-0.06854837387800217,
0.19002924859523773,
-0.004053595010191202,
-0.011910873465240002,
-0.3202807307243347,
0.06720833480358124,
0.6633568406105042,
0.1705578863620758,
0.049908414483070374,
-0.12009132653474808,
-0.19491912424564362,
0.06667234748601913,
-0.20264342427253723,
0.22427263855934143,
0.1875251978635788,
0.10282355546951294,
-0.1508483737707138,
-0.11956609785556793,
-0.2376105636358261,
0.13281391561031342,
0.11318034678697586,
-0.09631389379501343,
-0.08110909163951874,
-0.010609793476760387,
0.11421656608581543,
0.009175903163850307,
0.08133691549301147,
0.07669763267040253,
-0.2740303874015808,
-0.22796161472797394,
0.08672609180212021,
0.25692689418792725,
0.0281846821308136,
0.06335987895727158,
-0.21284037828445435,
-0.149959534406662,
0.30136340856552124,
-0.1503629833459854,
0.050440188497304916,
-0.12555621564388275,
0.028954263776540756,
-0.14591467380523682,
-0.16390132904052734,
-0.1253662258386612,
0.07815524935722351,
0.2210378646850586,
0.2431112676858902,
-0.14796946942806244,
-0.13878774642944336,
0.01391621120274067,
0.19972404837608337,
0.013063454069197178,
0.06378398090600967,
0.18675372004508972,
-0.0955517441034317,
-0.1479511559009552,
-0.052223268896341324,
0.15284399688243866,
0.09105528891086578,
0.05119894817471504,
0.13932888209819794,
-0.10762452334165573,
-0.16761870682239532,
-0.07130135595798492,
-0.04785776510834694,
0.04364733025431633,
-0.13695171475410461,
0.04438389465212822,
-0.09579074382781982,
-0.3169073760509491,
0.12955568730831146,
-0.1137460321187973,
0.15325435996055603,
-0.23265740275382996,
0.053788453340530396,
0.49972888827323914,
-0.0053860400803387165,
0.004535996355116367,
0.13124121725559235,
0.07853393256664276,
-0.27330732345581055,
-0.17119100689888,
-0.1787472665309906,
0.3230098783969879,
-0.05714242905378342,
0.17954206466674805,
-0.13709180057048798,
-0.10585632920265198,
0.021814052015542984,
-0.14816147089004517,
0.004276588559150696,
0.3385988771915436,
-0.28905799984931946,
0.09348456561565399,
-0.13111460208892822,
-0.0671406090259552,
0.05852919816970825,
0.10932368040084839,
0.28892412781715393,
-0.20485883951187134,
-0.0879218578338623,
0.05993030220270157,
0.035943545401096344,
0.09485679119825363,
-0.09435980767011642,
-0.23095937073230743,
0.18535883724689484,
-0.19603636860847473,
-0.4123215973377228,
-0.055196404457092285,
0.08780184388160706,
-0.05692014470696449,
0.1453336477279663,
-0.21432234346866608,
-0.09417545050382614,
0.49059802293777466,
-0.019888371229171753,
0.0445600226521492,
-0.05735776573419571,
0.39489811658859253,
-0.0006287568248808384,
0.1319427341222763,
-0.10406830161809921,
0.32061076164245605,
0.010807125829160213,
-0.2746306359767914,
0.1328868567943573,
0.03180396184325218,
0.2751740515232086,
0.16038118302822113,
-0.005013894289731979,
0.027510689571499825,
-0.17697203159332275,
0.19216197729110718,
0.32004398107528687,
-0.17839449644088745,
-0.1800045669078827,
0.04068998247385025,
-0.05079122260212898,
-0.008734303526580334,
0.23729921877384186,
-0.17664767801761627,
0.17282575368881226,
0.10343866795301437,
-0.25120842456817627,
-0.20020151138305664,
-0.0863189622759819,
0.2286812961101532,
0.08281222730875015,
-0.3046114146709442,
-0.16046284139156342,
0.13029709458351135,
0.1326771080493927,
0.07539457827806473,
-0.23018650710582733,
-0.14280551671981812,
-0.1864810287952423,
-0.16076894104480743,
0.016272272914648056,
-0.0820261538028717,
-0.09954404085874557,
-0.007036528550088406,
-0.018116921186447144,
-0.10478644073009491,
0.2127213329076767,
-0.22020862996578217,
-0.22436317801475525,
0.22770866751670837,
0.10372510552406311,
0.12484399229288101,
0.5195516347885132,
0.039064183831214905,
-0.3392467498779297,
-0.16370506584644318,
-0.22200457751750946,
0.03351037576794624,
0.031164294108748436,
0.09784623980522156,
-0.0873507633805275,
0.19444316625595093,
0.125227153301239,
0.07551085948944092,
0.3519567549228668,
0.12172099202871323,
0.05466444417834282,
0.1667521595954895,
-0.02511429972946644,
0.24778449535369873,
-0.11296224594116211,
-0.030194347724318504,
0.19722110033035278,
0.09887208789587021,
0.14681082963943481,
0.5035201907157898,
0.24818676710128784,
-0.08201401680707932,
0.0982268750667572,
0.10892684757709503,
0.2477574646472931,
-0.09705521911382675,
0.19182880222797394,
-0.12767687439918518,
0.10449166595935822,
-0.31986525654792786,
-0.06102406606078148,
-0.21093663573265076,
0.06669377535581589,
0.19256387650966644,
0.09153643995523453,
-0.2979986369609833,
0.2625975012779236,
0.20820404589176178,
0.3809055984020233,
-0.20509544014930725,
0.017268303781747818,
0.10237475484609604,
-0.14417092502117157,
0.009747263044118881,
-0.13164342939853668,
0.07836855202913284,
-0.007456178776919842,
-0.053461816161870956,
0.1669713258743286,
0.08510607481002808,
-0.18960817158222198,
-0.1350741982460022,
-0.07767844945192337,
-0.17948861420154572,
-0.10851969569921494,
-0.05226660147309303,
0.02961086854338646,
-0.0009648894192650914,
0.26478299498558044,
0.31811797618865967,
0.3064332604408264,
-0.17748692631721497,
-0.32253578305244446,
-0.45432567596435547,
0.2688333988189697,
-0.1637355089187622,
0.2144835740327835,
0.23934391140937805,
-0.01963578350841999,
-0.26208505034446716,
-0.07987922430038452,
-0.08459469676017761,
-0.003295487491413951,
0.10538236051797867,
0.1290694773197174,
-0.07525025308132172,
0.00264306110329926,
-0.21208934485912323,
-0.02658754587173462,
-0.1810481697320938,
-0.37747618556022644,
0.3497293293476105,
0.23871342837810516,
0.21708612143993378,
0.0704115703701973,
0.009165470488369465,
0.014447350054979324,
-0.03473938629031181,
0.4012491703033447,
-0.13162314891815186,
0.2158559411764145
] |
omim | https://www.omim.org/entry/251945 | O0gYNLn | MITOCHONDRIAL MYOPATHY WITH A DEFECT IN MITOCHONDRIAL-PROTEIN TRANSPORT | C1855034 | 31,760 | mitochondrial myopathy with a defect in mitochondrial-protein transport. eske' protein) and the 27.2-kD subunit of succinate dehydrogenase. Similar experiments with muscle homogenates indicated a deficiency of the subunit of succinate dehydrogenase, but normal levels of the precursor Rieske protein. The findings were interpreted as indicating a defect in the transport of the Rieske protein into mitochondria. Schapira et al. (1990) speculated that some iron-sulfur proteins of the mitochondrial respiratory chain may be encoded by a cluster of nuclear genes and that a mutation affecting a single coding sequence could account for the double deficiency. This could lead to a reduced synthesis of the 27.2-kD polypeptide and produce changes in the coding of the Rieske precursor sequence such that its receptor-mediated transport into mitochondria is defective.
Muscle
- Muscle weakness
- Exercise intolerance
Misc
- Fetal movements reduced
Lab
- Deficiency of respiratory-chain Complexes I to IV
- Mitochondrial deficiencies of both the iron-sulfur protein of Complex III (' | [
-0.10168342292308807,
0.10510309785604477,
0.2487305849790573,
-0.11137627810239792,
0.11800398677587509,
0.0025305962190032005,
-0.15002059936523438,
-0.14588479697704315,
-0.10577255487442017,
0.06705749779939651,
0.10757064074277878,
-0.23581470549106598,
0.015050036832690239,
-0.04860960692167282,
0.06322334706783295,
0.07031169533729553,
0.10276015847921371,
-0.20506204664707184,
-0.0677003338932991,
0.012012072838842869,
-0.18981756269931793,
-0.016215648502111435,
0.0003589671105146408,
0.38897010684013367,
0.01599491573870182,
0.052825137972831726,
-0.09491237998008728,
0.19822253286838531,
-0.07268964499235153,
0.08384266495704651,
-0.01983506605029106,
-0.06838537007570267,
0.12370290607213974,
-0.029968654736876488,
-0.09436247497797012,
-0.22347481548786163,
-0.14973077178001404,
-0.06948567181825638,
-0.055259037762880325,
-0.018172938376665115,
-0.30068090558052063,
-0.049070749431848526,
-0.026743771508336067,
-0.1535118818283081,
0.10226406157016754,
0.0780295878648758,
0.19432030618190765,
-0.11083533614873886,
-0.012039236724376678,
0.20811651647090912,
-0.06283659487962723,
0.0704101175069809,
0.19954493641853333,
-0.1899062693119049,
0.35469141602516174,
-0.05694625526666641,
-0.01804875209927559,
0.1413431018590927,
-0.06139752268791199,
-0.13441549241542816,
-0.07625224441289902,
0.1743166595697403,
-0.05309707298874855,
-0.10690871626138687,
-0.09782424569129944,
-0.259189248085022,
-0.11520445346832275,
0.16509926319122314,
0.32049503922462463,
-0.041070930659770966,
0.10513675957918167,
-0.028604691848158836,
0.2315922975540161,
0.11950621753931046,
0.12006807327270508,
-0.13816431164741516,
-0.048877544701099396,
-0.11484207957983017,
-0.016347529366612434,
-0.10580400377511978,
-0.14903634786605835,
0.12156679481267929,
-0.019012313336133957,
0.14067357778549194,
-0.0709201842546463,
0.12728531658649445,
-0.1028987318277359,
0.23444630205631256,
0.04837164282798767,
0.023129185661673546,
0.21722760796546936,
0.052207328379154205,
0.10886843502521515,
-0.12015321850776672,
0.14658218622207642,
-0.19751854240894318,
0.2789881229400635,
-0.1535777896642685,
-0.09557236731052399,
0.1139066219329834,
0.1942058801651001,
0.02186913788318634,
-0.1144951581954956,
0.05891447141766548,
0.06547435373067856,
-0.06965909898281097,
-0.13228781521320343,
0.14246194064617157,
-0.11132179945707321,
0.055388569831848145,
0.13208431005477905,
0.04864291846752167,
-0.09834477305412292,
-0.0012624538503587246,
-0.2645372450351715,
0.06693242490291595,
0.14686517417430878,
0.15286637842655182,
-0.11294545233249664,
0.21261484920978546,
-0.15947674214839935,
0.09154432266950607,
0.280146062374115,
0.06673891842365265,
0.22714397311210632,
0.16783180832862854,
0.1264636367559433,
-0.002494487911462784,
0.34095457196235657,
-0.09116272628307343,
-0.16090162098407745,
-0.17752620577812195,
-0.24927781522274017,
0.31813204288482666,
0.08640119433403015,
-0.044480931013822556,
-0.18030065298080444,
-0.19581066071987152,
0.0004829764075111598,
-0.04124278947710991,
-0.010399267077445984,
0.03919750079512596,
-0.01573052629828453,
0.1665409654378891,
-0.165246844291687,
0.1106492429971695,
0.1527942568063736,
-0.12772829830646515,
0.23565715551376343,
0.08059141039848328,
0.2602871060371399,
-0.3104468882083893,
0.11788533627986908,
-0.11856405436992645,
-0.014476231299340725,
0.14269253611564636,
0.14656229317188263,
-0.02679520472884178,
-0.041214264929294586,
-0.02776291035115719,
-0.06520160287618637,
-0.058650750666856766,
-0.09271509945392609,
-0.2290937602519989,
-0.3168272078037262,
-0.021830813959240913,
-0.10250871628522873,
0.17665129899978638,
0.18808715045452118,
-0.21666869521141052,
-0.1916862279176712,
0.12561871111392975,
-0.1571953296661377,
0.12283579260110855,
0.17881625890731812,
-0.015195424668490887,
0.0353853665292263,
-0.06263703852891922,
-0.09273751825094223,
0.09592431038618088,
0.0846518948674202,
-0.11288623511791229,
-0.20834392309188843,
0.11183580011129379,
0.03450000286102295,
-0.11268305778503418,
0.2323780655860901,
0.19015704095363617,
-0.23275521397590637,
-0.0070408848114311695,
0.3481844663619995,
-0.013572213239967823,
-0.04366837441921234,
0.022950679063796997,
-0.4498843550682068,
-0.08498454093933105,
-0.02895287238061428,
-0.1662435680627823,
0.033502887934446335,
0.0036953364033252,
0.23021100461483002,
-0.1457391232252121,
0.11375351995229721,
-0.015627935528755188,
0.014506001956760883,
0.07894256711006165,
0.13383996486663818,
-0.11099658161401749,
0.050636693835258484,
0.03128160536289215,
-0.036931462585926056,
0.14771120250225067,
-0.19679585099220276,
0.06360869109630585,
-0.19212324917316437,
0.17274273931980133,
0.035328928381204605,
0.08873441070318222,
-0.060183413326740265,
0.11832387745380402,
-0.06740982085466385,
0.12371062487363815,
0.109956756234169,
-0.23045530915260315,
-0.07704883068799973,
0.18996955454349518,
-0.28436172008514404,
0.06509466469287872,
-0.033996324986219406,
-0.11250311881303787,
0.13884080946445465,
-0.05550454184412956,
0.02188883163034916,
-0.09012199193239212,
-0.010332885198295116,
-0.0908568799495697,
0.08713819086551666,
0.06543092429637909,
-0.07788514345884323,
-0.061127886176109314,
-0.3165344297885895,
-0.010281339287757874,
-0.257908433675766,
0.05214816704392433,
0.10307477414608002,
-0.1655154675245285,
0.04696324095129967,
0.16031993925571442,
0.14389096200466156,
0.2346092015504837,
-0.038845159113407135,
-0.041139155626297,
0.18236923217773438,
-0.09648725390434265,
-0.3289107382297516,
-0.08709423243999481,
0.03249771520495415,
-0.10405821353197098,
-0.10433780401945114,
0.2557167112827301,
0.23569099605083466,
0.11402484029531479,
-0.10651791840791702,
0.23111481964588165,
-0.3852495849132538,
-0.05186372622847557,
-0.11089266091585159,
0.15670983493328094,
0.0840841606259346,
-0.18358683586120605,
-0.11972416937351227,
0.03455261141061783,
0.3711450695991516,
-0.07357654720544815,
-0.03631215915083885,
0.05352722108364105,
-0.05962718278169632,
0.2081698328256607,
0.33491775393486023,
-0.13322333991527557,
-0.18085849285125732,
0.24428731203079224,
0.012747141532599926,
0.0057204775512218475,
0.32731184363365173,
-0.1786346137523651,
0.12808281183242798,
0.07178575545549393,
-0.3285616338253021,
-0.009666797704994678,
-0.10201135277748108,
-0.0033050645142793655,
-0.21052438020706177,
0.06316628307104111,
0.1356700360774994,
-0.016204645857214928,
0.022223807871341705,
-0.004339827690273523,
0.29557883739471436,
-0.06600116938352585,
0.026390735059976578,
0.14013837277889252,
0.0763699933886528,
-0.04127224534749985,
-0.3621583878993988,
0.10929297655820847,
0.08502111583948135,
0.05265090987086296,
-0.01300357747823,
0.13993652164936066,
-0.4894132912158966,
-0.060009781271219254,
-0.013451777398586273,
0.15329128503799438,
-0.359198659658432,
-0.038316305726766586,
-0.15947438776493073,
0.037715665996074677,
-0.00144280306994915,
0.022189654409885406,
-0.09877524524927139,
0.05919651687145233,
-0.09324772655963898,
0.10036209225654602,
-0.015245593152940273,
0.03568222373723984,
-0.08295542001724243,
0.14142468571662903,
-0.26355570554733276,
0.020519660785794258,
0.12051977962255478,
0.20530524849891663,
0.026904696598649025,
-0.09205927699804306,
-0.01597992144525051,
0.05130772665143013,
0.23308265209197998,
0.050100602209568024,
-0.3078081011772156,
-0.2496122270822525,
0.06879908591508865,
-0.343350350856781,
-0.1357833445072174,
-0.27339380979537964,
0.057113610208034515,
0.11395303905010223,
0.01134711503982544,
0.280059814453125,
0.14083276689052582,
-0.10633392632007599,
-0.2621006667613983,
0.23176489770412445,
0.06900971382856369,
-0.2334779053926468,
0.08225708454847336,
-0.18023210763931274,
0.026177668944001198,
0.38970378041267395,
0.0045017097145318985,
-0.020855342969298363,
-0.10836037993431091,
0.05574757233262062,
0.13127866387367249,
-0.06948421150445938,
-0.02473093941807747,
-0.03795932978391647,
0.11211733520030975,
0.09052041172981262,
0.24042978882789612,
-0.04502052813768387,
0.01151224784553051,
-0.06359118223190308,
-0.09896297007799149,
-0.03694329038262367,
-0.27688702940940857,
-0.10274826735258102,
-0.014133762568235397,
0.017909618094563484,
-0.05365343764424324,
-0.0850619301199913,
-0.025114867836236954,
0.20297671854496002,
0.0403498150408268,
0.31029650568962097,
0.0207122303545475,
0.29016178846359253,
-0.03983446583151817,
0.09898856282234192,
0.10369495302438736,
-0.07646831125020981,
-0.14756883680820465,
0.24379435181617737,
-0.031556110829114914,
-0.07801993191242218,
0.33479949831962585,
0.20460529625415802,
-0.060695040971040726,
0.03668762743473053,
-0.11219292879104614,
-0.05376605689525604,
-0.10809771716594696,
-0.3884832262992859,
0.2066246122121811,
-0.004950900562107563,
0.10425018519163132,
0.09155642241239548,
0.22090989351272583,
0.0890035480260849,
-0.230417400598526,
-0.011536946520209312,
-0.22537674009799957,
-0.10831323266029358,
-0.005515028722584248,
0.04619034752249718,
-0.2260323166847229,
-0.008621416054666042,
0.25882580876350403,
0.28778934478759766,
0.019208809360861778,
0.11319609731435776,
-0.13484631478786469,
-0.20248039066791534,
0.41200315952301025,
-0.11823032051324844,
0.13423652946949005,
0.09427934139966965,
0.1019432321190834,
0.04538440331816673,
0.14888419210910797,
0.0020563583821058273,
0.1148359552025795,
-0.12687402963638306,
-0.00488768657669425,
-0.04396892711520195,
0.16285769641399384,
0.16255134344100952,
-0.0012047762284055352,
0.1064426526427269,
0.011721611022949219,
-0.07614801079034805,
0.24303995072841644,
0.07707664370536804,
0.06649915874004364,
-0.13877318799495697,
-0.0900292843580246,
0.23473739624023438,
0.03432275354862213,
0.17637899518013,
0.003348201746121049,
0.008845160715281963,
0.0024533187970519066,
-0.02205757237970829,
0.24880750477313995,
-0.07908452302217484,
-0.07189063727855682,
0.13301987946033478,
0.08014927804470062,
-0.07856651395559311,
-0.004990318790078163,
-0.2000330686569214,
0.15302088856697083,
0.04023689031600952,
0.2120935171842575,
-0.15962444245815277,
-0.06266716122627258,
0.3992677628993988,
-0.20417149364948273,
-0.0729387104511261,
0.14110910892486572,
0.05773663893342018,
0.028311608359217644,
0.0015066541964188218,
0.035213153809309006,
0.04849996790289879,
0.05420268326997757,
-0.041077446192502975,
0.06896921247243881,
-0.02632712759077549,
-0.08386805653572083,
0.11400523781776428,
-0.0301212165504694,
-0.18025434017181396,
-0.24281127750873566,
0.008680818602442741,
0.18495088815689087,
0.03745851293206215,
-0.06078377366065979,
-0.17290574312210083,
0.2537989914417267,
0.07736238092184067,
-0.0626036748290062,
0.034936919808387756,
-0.04663423076272011,
0.3000216484069824,
-0.07023657858371735,
-0.00565409054979682,
-0.0001501145598012954,
-0.05196772888302803,
-0.08058628439903259,
0.15729087591171265,
0.07701228559017181,
-0.28105056285858154,
0.1548972874879837,
-0.046001020818948746,
0.047818027436733246,
-0.006562064867466688,
-0.11048492044210434,
-0.3787343204021454,
-0.041103802621364594,
0.481259822845459,
0.16606077551841736,
0.024108346551656723,
-0.04705303534865379,
-0.20022964477539062,
0.03689732775092125,
-0.1840783804655075,
0.22676551342010498,
0.22318674623966217,
0.19970999658107758,
-0.18404565751552582,
-0.010979529470205307,
-0.3007873594760895,
0.21137109398841858,
0.09282384812831879,
-0.0450279638171196,
-0.10227922350168228,
0.017688116058707237,
0.11002794653177261,
0.04110864922404289,
-0.02753502130508423,
0.09349318593740463,
-0.1059073954820633,
-0.23273374140262604,
0.09484562277793884,
0.18334902822971344,
0.020396174862980843,
0.15827254951000214,
-0.16326011717319489,
-0.10969754308462143,
0.18723322451114655,
-0.055870793759822845,
0.00849856622517109,
-0.11568428575992584,
-0.011079992167651653,
-0.06367722898721695,
-0.07707221060991287,
-0.12681756913661957,
0.032295066863298416,
0.05913490802049637,
0.20107118785381317,
-0.16563312709331512,
-0.24460375308990479,
-0.02346763014793396,
0.1717686504125595,
-0.032046250998973846,
-0.01252174936234951,
0.1239241436123848,
0.00860865879803896,
-0.08105844259262085,
-0.010127207264304161,
0.09077027440071106,
-0.009594367817044258,
-0.032362379133701324,
0.02539142780005932,
-0.053085483610630035,
-0.10534524917602539,
0.11432972550392151,
-0.09132815897464752,
-0.036295659840106964,
-0.09817545861005783,
0.014989614486694336,
-0.05343378335237503,
-0.1254272758960724,
0.08880558609962463,
-0.14117789268493652,
0.10261710733175278,
-0.18116730451583862,
0.00817052461206913,
0.4003218710422516,
0.11752299219369888,
-0.06553398072719574,
-0.039886344224214554,
0.06868944317102432,
-0.21932944655418396,
-0.015865324065089226,
-0.08993901312351227,
0.16199712455272675,
-0.045192036777734756,
0.20464208722114563,
-0.140121728181839,
-0.1035439744591713,
0.05885157734155655,
-0.12421980500221252,
0.10346107929944992,
0.20585258305072784,
-0.21136905252933502,
-0.010392698459327221,
-0.16527597606182098,
-0.02056640200316906,
0.08732974529266357,
0.02149113081395626,
0.28096914291381836,
-0.036383844912052155,
-0.08097274601459503,
0.07621748745441437,
0.003690089099109173,
0.1014758050441742,
-0.09584183245897293,
-0.03034457005560398,
0.141032874584198,
-0.24421799182891846,
-0.4003761112689972,
-0.009254653938114643,
0.042757049202919006,
0.030579691752791405,
0.12647128105163574,
-0.010567789897322655,
-0.16371473670005798,
0.45314857363700867,
-0.005598106421530247,
0.04680991545319557,
0.049362823367118835,
0.2901134788990021,
0.020643047988414764,
0.030743064358830452,
-0.04393235594034195,
0.22812217473983765,
-0.08068638294935226,
-0.07137799263000488,
0.054314564913511276,
-0.047084126621484756,
0.20559802651405334,
0.09504871070384979,
-0.05266148969531059,
-0.09992924332618713,
-0.11479264497756958,
0.14222261309623718,
0.23091690242290497,
-0.11840038001537323,
-0.12971729040145874,
-0.011431644670665264,
-0.0002490074548404664,
-0.029975280165672302,
0.18074268102645874,
-0.13513129949569702,
0.14001581072807312,
-0.03740904480218887,
-0.24856282770633698,
-0.14077037572860718,
-0.13368506729602814,
0.205902561545372,
0.04420560598373413,
-0.39289841055870056,
-0.04991800710558891,
0.12450491636991501,
0.04157083481550217,
0.2044355571269989,
-0.17818638682365417,
0.023086195811629295,
-0.14422692358493805,
-0.074215367436409,
0.10740482062101364,
-0.14042609930038452,
-0.03497349098324776,
0.03771039471030235,
0.08771387487649918,
-0.0418892428278923,
0.15561416745185852,
-0.22326596081256866,
-0.2090258151292801,
0.05282188206911087,
0.1457279771566391,
0.05883688107132912,
0.31261032819747925,
0.018038434907794,
-0.22693303227424622,
-0.11690019816160202,
-0.04024871438741684,
-0.010472207330167294,
0.057487133890390396,
0.14801670610904694,
-0.130402609705925,
0.07462289184331894,
0.06145446375012398,
0.003959351684898138,
0.31114405393600464,
0.021848399192094803,
0.09972918778657913,
0.24650751054286957,
-0.00018333207117393613,
0.1785838007926941,
-0.12455368041992188,
0.0798741951584816,
0.17969857156276703,
0.036020949482917786,
0.08382140845060349,
0.49186837673187256,
0.2100922167301178,
-0.11395683884620667,
0.0626058429479599,
0.05275977402925491,
0.29230430722236633,
-0.1020338386297226,
0.18988513946533203,
-0.12317407131195068,
0.0048679690808057785,
-0.13571074604988098,
-0.14869192242622375,
-0.17559516429901123,
-0.008825097233057022,
0.01681906171143055,
0.091140978038311,
-0.20608583092689514,
0.27599260210990906,
0.05094257742166519,
0.22865889966487885,
-0.1527959704399109,
0.049539532512426376,
0.04015228524804115,
-0.11810944229364395,
-0.09463146328926086,
-0.11092696338891983,
0.0356023944914341,
0.04026161506772041,
0.027350548654794693,
0.11865919828414917,
0.06488369405269623,
-0.1297265738248825,
-0.018021337687969208,
-0.0746324360370636,
-0.16742372512817383,
-0.10405408591032028,
-0.005311715416610241,
0.0787743404507637,
-0.03645751625299454,
0.18565155565738678,
0.20290324091911316,
0.12003038078546524,
-0.16261281073093414,
-0.19573108851909637,
-0.24655260145664215,
0.12491763383150101,
-0.11203847080469131,
0.20597141981124878,
0.13685660064220428,
-0.09426616132259369,
-0.18668586015701294,
-0.024088548496365547,
-0.09913374483585358,
0.05990153178572655,
0.09954293817281723,
0.13355503976345062,
0.05921173095703125,
-0.08512523025274277,
-0.12560856342315674,
-0.04462151229381561,
-0.1313909888267517,
-0.32867690920829773,
0.2832401692867279,
0.27100348472595215,
0.044896241277456284,
-0.07594534754753113,
0.04213792458176613,
-0.003633220214396715,
-0.021304499357938766,
0.3063225746154785,
-0.07792443782091141,
0.17162971198558807
] |
omim | https://www.omim.org/entry/251945 | O0gYNLn | MITOCHONDRIAL MYOPATHY WITH A DEFECT IN MITOCHONDRIAL-PROTEIN TRANSPORT | C1855034 | 31,760 | mitochondrial myopathy with a defect in mitochondrial-protein transport. by a cluster of nuclear genes and that a mutation affecting a single coding sequence could account for the double deficiency. This could lead to a reduced synthesis of the 27.2-kD polypeptide and produce changes in the coding of the Rieske precursor sequence such that its receptor-mediated transport into mitochondria is defective.
Muscle
- Muscle weakness
- Exercise intolerance
Misc
- Fetal movements reduced
Lab
- Deficiency of respiratory-chain Complexes I to IV
- Mitochondrial deficiencies of both the iron-sulfur protein of Complex III ('Rieske' protein) and the 27.2-kD subunit of succinate dehydrogenase
- Defective transport of the Rieske protein into mitochondria
Inheritance
- Autosomal recessive
▲ Close | [
-0.21375225484371185,
0.017620079219341278,
0.3078675866127014,
-0.14257469773292542,
0.033494751900434494,
0.06673026829957962,
-0.25566422939300537,
-0.12347080558538437,
-0.13752508163452148,
0.14658468961715698,
0.18354469537734985,
-0.266045480966568,
-0.05552728846669197,
0.03403022140264511,
0.1528802365064621,
0.03601652383804321,
0.06375305354595184,
-0.14131425321102142,
-0.01791873201727867,
0.00293633877299726,
-0.26853495836257935,
-0.032451845705509186,
-0.10487250238656998,
0.38847416639328003,
-0.016629356890916824,
0.0379943884909153,
-0.18934467434883118,
0.2925678491592407,
-0.17927294969558716,
0.15387079119682312,
-0.04840339720249176,
0.0083963917568326,
0.1961701214313507,
0.04469529539346695,
-0.07659895718097687,
-0.22585716843605042,
-0.3055567741394043,
-0.10093016177415848,
-0.042773082852363586,
0.06243628263473511,
-0.30392491817474365,
-0.03584979474544525,
-0.08917682617902756,
-0.1263761818408966,
0.20091873407363892,
0.035195305943489075,
0.21071280539035797,
-0.16130918264389038,
-0.0317215733230114,
0.21656838059425354,
-0.03582712262868881,
0.07104392349720001,
0.28906571865081787,
-0.21516229212284088,
0.4492463171482086,
-0.023203114047646523,
-0.05565424636006355,
0.09010070562362671,
0.014089458622038364,
-0.19904354214668274,
-0.11881615966558456,
0.16565172374248505,
0.014699188992381096,
-0.10326428711414337,
-0.08047077804803848,
-0.3004823625087738,
-0.1427592933177948,
0.11097120493650436,
0.3770405054092407,
-0.04337389022111893,
0.09708509594202042,
-0.07366403937339783,
0.18121595680713654,
0.176261767745018,
0.14645035564899445,
-0.11880585551261902,
-0.09072530269622803,
-0.1588677316904068,
-0.004540680907666683,
-0.08154917508363724,
-0.11139411479234695,
0.11690425127744675,
-0.05324598774313927,
0.10829543322324753,
-0.008865531533956528,
0.20803400874137878,
-0.11823061108589172,
0.2248261421918869,
0.09016422182321548,
-0.03878738731145859,
0.24256260693073273,
-0.003428542520850897,
0.1151922345161438,
-0.09207778424024582,
0.19602183997631073,
-0.14799383282661438,
0.28132233023643494,
-0.13741996884346008,
-0.18829114735126495,
0.09542009234428406,
0.12598805129528046,
0.014188735745847225,
-0.07216495275497437,
0.13738468289375305,
0.039907414466142654,
-0.07376169413328171,
-0.20308896899223328,
0.08780312538146973,
-0.09358157962560654,
0.027286624535918236,
0.14627420902252197,
0.05895616114139557,
-0.14968596398830414,
-0.0566956102848053,
-0.2714020609855652,
0.058304477483034134,
0.13591820001602173,
0.11034037172794342,
-0.09000462293624878,
0.18583430349826813,
-0.17909003794193268,
0.10954006016254425,
0.3400135934352875,
0.09703444689512253,
0.21387386322021484,
0.21348461508750916,
0.12417818605899811,
0.022848280146718025,
0.3350428640842438,
-0.09491720050573349,
-0.09315900504589081,
-0.21700221300125122,
-0.19404028356075287,
0.410972535610199,
0.06456978619098663,
0.01342483889311552,
-0.16711845993995667,
-0.18504172563552856,
0.06133711710572243,
-0.002747317310422659,
-0.09152847528457642,
0.008914417587220669,
-0.005624487996101379,
0.0957055613398552,
-0.19742874801158905,
0.24005912244319916,
0.16310915350914001,
-0.22421133518218994,
0.30701643228530884,
0.09767570346593857,
0.2495792806148529,
-0.305059015750885,
0.07405032217502594,
-0.15689551830291748,
-0.05995770916342735,
0.1437441110610962,
0.10284996032714844,
-0.03393378481268883,
0.06589534133672714,
-0.06401228159666061,
-0.042882040143013,
-0.07953418791294098,
-0.16363166272640228,
-0.15990784764289856,
-0.4233487546443939,
-0.10877513140439987,
-0.12372604757547379,
0.18484781682491302,
0.3182474672794342,
-0.16846129298210144,
-0.11645577847957611,
0.11446399986743927,
-0.10545792430639267,
0.14668425917625427,
0.2481246143579483,
0.04204291105270386,
0.06351476162672043,
-0.1492108404636383,
-0.07580525428056717,
0.05634477362036705,
0.049149543046951294,
-0.12133114039897919,
-0.1433979570865631,
0.12329964339733124,
0.06955569237470627,
-0.21130451560020447,
0.2590354382991791,
0.1570233255624771,
-0.25046584010124207,
-0.10296212881803513,
0.33133426308631897,
-0.07217153161764145,
-0.02993595041334629,
-0.03917510434985161,
-0.48159074783325195,
-0.10477814823389053,
-0.05746953934431076,
-0.18688571453094482,
0.052438270300626755,
-0.05318406596779823,
0.17666538059711456,
-0.24584928154945374,
0.15800218284130096,
0.03867057338356972,
0.04949240759015083,
0.1677316278219223,
0.10798867046833038,
-0.057760175317525864,
0.17030617594718933,
0.008723066188395023,
-0.05278026685118675,
0.17223092913627625,
-0.16731895506381989,
0.09878415614366531,
-0.1758446842432022,
0.18364885449409485,
-0.029085785150527954,
0.1322895884513855,
-0.12598752975463867,
0.06827744841575623,
-0.1365526020526886,
0.16677813231945038,
0.23418672382831573,
-0.30576056241989136,
-0.10185771435499191,
0.08757536858320236,
-0.17195530235767365,
-0.03464177995920181,
0.0001643692230572924,
-0.11161934584379196,
0.20751777291297913,
-0.018739189952611923,
0.10642104595899582,
-0.19664578139781952,
-0.01384387444704771,
-0.07707919180393219,
0.12987886369228363,
0.004582221154123545,
-0.0008813912863843143,
-0.07642818242311478,
-0.2667365074157715,
-0.048454441130161285,
-0.28542137145996094,
0.05896461382508278,
0.12422861903905869,
-0.09649229049682617,
0.01606147177517414,
0.21653030812740326,
0.20387305319309235,
0.17920322716236115,
-0.0016340762376785278,
-0.05736098065972328,
0.27042093873023987,
-0.02280678227543831,
-0.40273529291152954,
-0.11916175484657288,
0.02223151922225952,
-0.152242511510849,
-0.07687871903181076,
0.38513776659965515,
0.21904510259628296,
0.0823492780327797,
-0.07074323296546936,
0.27033042907714844,
-0.3289373815059662,
-0.08989328891038895,
-0.10487235337495804,
0.21246154606342316,
0.0663052573800087,
-0.19817878305912018,
-0.1190219596028328,
0.024008505046367645,
0.4175846576690674,
-0.049845751374959946,
-0.13481996953487396,
0.017204148694872856,
-0.10808811336755753,
0.16684070229530334,
0.291199654340744,
-0.09119582176208496,
-0.22145257890224457,
0.2219965010881424,
0.08559171855449677,
-0.026170523837208748,
0.38904663920402527,
-0.25500595569610596,
0.19881075620651245,
-0.022585807368159294,
-0.3707601726055145,
-0.008605550043284893,
-0.1652197241783142,
-0.06926719099283218,
-0.32259485125541687,
0.1047983318567276,
0.17354252934455872,
-0.07933083921670914,
0.06970767676830292,
0.031770993024110794,
0.2928328514099121,
0.053513772785663605,
0.040606431663036346,
0.2615965008735657,
0.03500870242714882,
-0.01953347772359848,
-0.33709603548049927,
0.13741493225097656,
0.04245636612176895,
0.023996980860829353,
0.027894046157598495,
0.1746232807636261,
-0.5465105772018433,
-0.022579722106456757,
-0.06083305925130844,
0.10318391770124435,
-0.2757791578769684,
-0.061666857451200485,
-0.17574411630630493,
0.02076081559062004,
0.05311086028814316,
0.02471698634326458,
-0.09867598116397858,
0.10230471938848495,
-0.20605647563934326,
0.08190752565860748,
-0.026939846575260162,
0.0038156842347234488,
-0.06221410632133484,
0.15148323774337769,
-0.28278079628944397,
0.034380216151475906,
0.04865233972668648,
0.2413259744644165,
0.07468027621507645,
0.05776809900999069,
0.0018897982081398368,
-0.016813497990369797,
0.2852857708930969,
0.06843993812799454,
-0.3012325167655945,
-0.3148769438266754,
0.12135202437639236,
-0.414022833108902,
-0.09524974226951599,
-0.25233957171440125,
0.14459238946437836,
0.11581840366125107,
-0.022687437012791634,
0.35913339257240295,
0.13933932781219482,
-0.0003509465022943914,
-0.2751782238483429,
0.24246837198734283,
0.06730449199676514,
-0.11472471058368683,
0.09803714603185654,
-0.20741866528987885,
-0.0022211354225873947,
0.36168399453163147,
0.021053841337561607,
-0.06311798840761185,
-0.1453334093093872,
0.08028385043144226,
0.08854436874389648,
-0.0433199405670166,
-0.05621767044067383,
-0.05256377533078194,
0.043366845697164536,
0.12934771180152893,
0.20822550356388092,
-0.023882264271378517,
-0.014400635845959187,
-0.07786430418491364,
-0.16025236248970032,
-0.007794826291501522,
-0.3037801682949066,
-0.13321611285209656,
-0.008680367842316628,
-0.009952065534889698,
-0.05178263783454895,
-0.10463235527276993,
-0.04444531351327896,
0.26556095480918884,
-0.013045918196439743,
0.3489169180393219,
0.02014577016234398,
0.3938121497631073,
-0.04231647029519081,
0.07158016413450241,
0.0761970579624176,
-0.028937507420778275,
-0.13836969435214996,
0.2393132597208023,
-0.054043248295784,
-0.03831544145941734,
0.18625953793525696,
0.15997236967086792,
-0.08849509805440903,
0.024973586201667786,
-0.146791011095047,
-0.029233161360025406,
0.00019967157277278602,
-0.3509484529495239,
0.3120253086090088,
-0.0562911294400692,
0.1435304880142212,
0.10322153568267822,
0.17203950881958008,
0.09755357354879379,
-0.20741108059883118,
-0.0839838758111,
-0.23484402894973755,
-0.10031025856733322,
-0.01919098012149334,
0.06407096236944199,
-0.2440270632505417,
-0.05193549767136574,
0.2881644368171692,
0.22087371349334717,
0.03201018646359444,
0.06793376803398132,
-0.1872785985469818,
-0.12716594338417053,
0.4651157557964325,
-0.15980708599090576,
0.09982091933488846,
0.07091556489467621,
0.13098035752773285,
0.03067249059677124,
0.10229873657226562,
0.034257274121046066,
0.13430319726467133,
-0.1536644995212555,
0.022879023104906082,
-0.06605606526136398,
0.20280297100543976,
0.1301586627960205,
-0.02701405994594097,
0.19689452648162842,
0.019063802435994148,
0.03642023727297783,
0.28005608916282654,
0.018667494878172874,
0.0982033982872963,
-0.20318782329559326,
-0.12606142461299896,
0.22372330725193024,
-0.06178875267505646,
0.1683221459388733,
-0.01894247904419899,
-0.040641333907842636,
-0.06077242270112038,
0.018180321902036667,
0.28535977005958557,
0.026281675323843956,
-0.08763722330331802,
0.08644289523363113,
0.08872263133525848,
-0.07199403643608093,
-0.02143210917711258,
-0.129985049366951,
0.17176553606987,
0.025041352957487106,
0.24585925042629242,
-0.23372171819210052,
-0.01079601515084505,
0.43664827942848206,
-0.1123310849070549,
-0.09643584489822388,
0.15639887750148773,
0.12728466093540192,
0.10306015610694885,
0.028364479541778564,
0.05780237913131714,
0.054605044424533844,
0.1553584784269333,
0.02564876526594162,
0.07633698731660843,
-0.03775251656770706,
-0.0760757103562355,
0.05055219680070877,
-0.04788153991103172,
-0.1218629702925682,
-0.21448875963687897,
0.050328776240348816,
0.21948133409023285,
0.08674371242523193,
-0.045836176723241806,
-0.1587756872177124,
0.33641260862350464,
0.03376523032784462,
-0.09917444735765457,
0.10033250600099564,
-0.11764095723628998,
0.3359534442424774,
-0.09115622937679291,
0.03652001917362213,
0.007770759519189596,
-0.029045021161437035,
-0.01985243707895279,
0.15780916810035706,
0.11404326558113098,
-0.29952535033226013,
0.1334000676870346,
0.01980002596974373,
0.1274118721485138,
-0.010050308890640736,
-0.011018967255949974,
-0.29726719856262207,
0.04571761563420296,
0.5684421062469482,
0.24770715832710266,
0.08497679233551025,
0.029212575405836105,
-0.1812833696603775,
0.08571119606494904,
-0.2218363881111145,
0.21407024562358856,
0.2755967974662781,
0.1809074729681015,
-0.14489759504795074,
-0.025197332724928856,
-0.2992078959941864,
0.10939710587263107,
0.18302945792675018,
-0.11170291155576706,
-0.10569500178098679,
0.026502162218093872,
0.043481551110744476,
-0.003276021219789982,
-0.026954151690006256,
0.0831807553768158,
-0.17754149436950684,
-0.2135625034570694,
0.10808835178613663,
0.20572017133235931,
0.00928843580186367,
0.09812615066766739,
-0.08430783450603485,
-0.0433039665222168,
0.2043430358171463,
-0.12492360174655914,
0.029964711517095566,
-0.19132651388645172,
0.017521807923913002,
-0.028889024630188942,
-0.03028208389878273,
-0.13969404995441437,
0.04259585216641426,
0.08497994393110275,
0.13638724386692047,
-0.08270937949419022,
-0.174250990152359,
0.013902969658374786,
0.18711549043655396,
0.025651102885603905,
-0.011178787797689438,
0.16915278136730194,
-0.02214665338397026,
-0.06794538348913193,
-0.0672352984547615,
0.124509297311306,
-0.044619541615247726,
0.0356748066842556,
0.06856226921081543,
-0.07211190462112427,
-0.1905049830675125,
0.05277114734053612,
-0.03772478550672531,
-0.017222149297595024,
-0.08904285728931427,
0.07970653474330902,
-0.11693677306175232,
-0.2252616584300995,
0.15575312077999115,
-0.080693319439888,
0.08309253305196762,
-0.10047245770692825,
0.1583758443593979,
0.3456787168979645,
0.05489141121506691,
-0.02426101826131344,
0.007502836640924215,
-0.05950953811407089,
-0.2113157957792282,
-0.0448148213326931,
-0.1132277101278305,
0.20061376690864563,
-0.10292015969753265,
0.17536558210849762,
-0.12925207614898682,
-0.12381958961486816,
0.029270322993397713,
-0.16908498108386993,
0.11200682818889618,
0.17537648975849152,
-0.2351660281419754,
0.06813523173332214,
-0.23928619921207428,
-0.030240362510085106,
0.03853601962327957,
0.015290236100554466,
0.28020602464675903,
-0.0769207775592804,
-0.09934893250465393,
-0.0016362066380679607,
0.07286356389522552,
0.03304465487599373,
-0.09397315233945847,
-0.12104195356369019,
0.23216977715492249,
-0.16875523328781128,
-0.33219775557518005,
-0.09640005975961685,
0.08990005403757095,
0.04742813482880592,
0.1591845154762268,
-0.08999975025653839,
-0.06946351379156113,
0.3985353112220764,
-0.03139195591211319,
0.1064872145652771,
-0.0065118009224534035,
0.29668211936950684,
-0.01028612069785595,
0.12739251554012299,
-0.06264155358076096,
0.3122510015964508,
-0.030905794352293015,
-0.20929856598377228,
0.16448946297168732,
-0.02071145549416542,
0.18980811536312103,
0.08299145102500916,
-0.17632721364498138,
-0.0799647867679596,
0.02441030740737915,
0.12757979333400726,
0.21444211900234222,
-0.16821470856666565,
-0.1769580990076065,
0.06943339854478836,
-0.031658388674259186,
-0.07449451833963394,
0.17988716065883636,
-0.09762484580278397,
0.17865407466888428,
0.007008961867541075,
-0.17532221972942352,
-0.07154711335897446,
-0.20832516252994537,
0.22498805820941925,
-0.061015188694000244,
-0.3525884747505188,
-0.07378271222114563,
0.17370402812957764,
0.09803993254899979,
0.2599554657936096,
-0.18758399784564972,
-0.008742643520236015,
-0.07317659258842468,
-0.05334660783410072,
0.09528180211782455,
-0.08017616719007492,
-0.02261628955602646,
-0.030502555891871452,
0.01490379124879837,
-0.026759520173072815,
0.2511613368988037,
-0.21937651932239532,
-0.13519857823848724,
0.06654440611600876,
0.21743741631507874,
0.05737592652440071,
0.45090723037719727,
0.13197042047977448,
-0.23216679692268372,
-0.169205442070961,
-0.19628386199474335,
0.04728676751255989,
0.027462836354970932,
0.14671576023101807,
-0.07675280421972275,
0.09371060878038406,
0.04474392160773277,
0.01889670453965664,
0.2906166613101959,
0.0207790769636631,
0.08813159167766571,
0.10472728312015533,
-0.05504380539059639,
0.13556022942066193,
-0.10913395136594772,
0.029992103576660156,
0.21116283535957336,
0.017284421250224113,
0.11936084926128387,
0.5045042037963867,
0.22766174376010895,
-0.15394227206707,
0.10744152218103409,
0.01556126493960619,
0.27374914288520813,
-0.07773303240537643,
0.22468899190425873,
-0.10066715627908707,
-0.015936871990561485,
-0.17343862354755402,
-0.11410098522901535,
-0.27030646800994873,
0.03102058358490467,
0.08008771389722824,
0.04472734034061432,
-0.20357872545719147,
0.29975754022598267,
0.03602299839258194,
0.21313342452049255,
-0.13224510848522186,
0.028136812150478363,
0.03820086270570755,
-0.1084660217165947,
-0.04363420233130455,
-0.07286513596773148,
0.03183702379465103,
0.051799338310956955,
0.08306277543306351,
0.14462347328662872,
0.12191350758075714,
-0.22310441732406616,
-0.12856148183345795,
-0.0526919960975647,
-0.19234225153923035,
-0.08057422190904617,
-0.06778812408447266,
0.14777234196662903,
-0.05360809341073036,
0.17390356957912445,
0.2701028883457184,
0.13594277203083038,
-0.12378890812397003,
-0.16961105167865753,
-0.35575753450393677,
0.18806199729442596,
-0.03806078061461449,
0.18307256698608398,
0.13184386491775513,
-0.12065243721008301,
-0.2179245799779892,
-0.08680053055286407,
-0.16951949894428253,
0.0711083635687828,
0.2044696807861328,
0.1959361881017685,
0.05112799257040024,
-0.03821338713169098,
-0.1722463220357895,
-0.05179057642817497,
-0.20028573274612427,
-0.33122655749320984,
0.2826785445213318,
0.25482502579689026,
0.06267823278903961,
-0.07026416063308716,
-0.035951897501945496,
-0.03614148870110512,
-0.009591735899448395,
0.2561931014060974,
-0.07012899965047836,
0.17050673067569733
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. SummaryClinical characteristics.Proteus syndrome is characterized by progressive segmental or patchy overgrowth most commonly affecting the skeleton, skin, adipose, and central nervous systems. In most individuals Proteus syndrome has modest or no manifestations at birth, develops and progresses rapidly beginning in the toddler period, and relentlessly progresses through childhood, causing severe overgrowth and disfigurement. It is associated with a range of tumors, pulmonary complications, and a striking predisposition to deep vein thrombosis and pulmonary embolism.Diagnosis/testing.The diagnosis of Proteus syndrome is based on clinical criteria that include all three general characteristics (mosaic distribution of lesions, sporadic occurrence, progressive course) and additional specific clinical criteria. Identification of a mosaic, somatic, heterozygous pathogenic variant in AKT1 by molecular genetic testing can establish the diagnosis if the clinical criteria are inconclusive.Management.Treatment of manifestations: Management of overgrowth is the chief concern; the approaches are diverse and include various orthopedic procedures to delay or halt linear bone growth; rehabilitation | [
-0.07815822958946228,
-0.10709679126739502,
-0.14046479761600494,
-0.36379897594451904,
-0.0026512204203754663,
-0.03976122662425041,
-0.09547837823629379,
-0.22837451100349426,
-0.009537270292639732,
0.14805427193641663,
-0.05007155239582062,
0.09513529390096664,
0.02829897403717041,
-0.03215860202908516,
-0.17081446945667267,
0.48471036553382874,
-0.11259285360574722,
0.15440039336681366,
0.14489997923374176,
0.14839746057987213,
0.024422835558652878,
-0.10989673435688019,
-0.10773875564336777,
0.06231525167822838,
-0.010845406912267208,
-0.19233141839504242,
0.26139190793037415,
0.08253596723079681,
-0.10825184732675552,
-0.24665966629981995,
-0.013771072030067444,
0.007229567039757967,
-0.17182868719100952,
-0.5064749717712402,
0.016802551224827766,
-0.34049203991889954,
-0.19777558743953705,
0.024947889149188995,
0.2092665731906891,
-0.009492845274508,
-0.0050715915858745575,
0.0066508143208920956,
-0.2708386182785034,
-0.1862678825855255,
0.3713151812553406,
-0.14817661046981812,
0.10475215315818787,
0.3412773013114929,
0.13697423040866852,
0.29458531737327576,
0.21668246388435364,
0.048555489629507065,
0.09370015561580658,
-0.12593291699886322,
0.13930903375148773,
-0.09035512059926987,
-0.007093637250363827,
-0.160435289144516,
-0.4729493260383606,
-0.016515659168362617,
0.24804720282554626,
0.12928995490074158,
0.21354597806930542,
-0.4322083294391632,
0.04289735108613968,
-0.04171265289187431,
-0.07368484139442444,
0.2746763825416565,
0.08659350126981735,
0.06113860756158829,
0.4327620267868042,
-0.0819099098443985,
-0.12616974115371704,
-0.14552851021289825,
0.15358683466911316,
-0.11892683804035187,
0.2552724778652191,
-0.1728079468011856,
-0.09473353624343872,
-0.13145074248313904,
-0.03796752914786339,
-0.09356816858053207,
-0.23635856807231903,
0.04432911053299904,
-0.34156593680381775,
-0.12975925207138062,
-0.07220140844583511,
-0.1333739310503006,
-0.12558606266975403,
0.011393580585718155,
0.014980718493461609,
0.07089149206876755,
0.16451625525951385,
0.2234109491109848,
0.1745566576719284,
-0.021490957587957382,
0.09900309145450592,
0.0226846132427454,
-0.35749170184135437,
-0.1279928982257843,
0.26389047503471375,
0.385465532541275,
-0.04309454187750816,
0.013620325364172459,
0.0482921302318573,
0.005746819544583559,
-0.20222727954387665,
0.0034027283545583487,
0.06356240063905716,
0.03385547921061516,
0.10256293416023254,
-0.15437056124210358,
-0.08283592015504837,
0.04328015819191933,
-0.37916436791419983,
-0.2108933925628662,
0.007321290671825409,
0.015010248869657516,
-0.05187000334262848,
-0.2740062475204468,
-0.11512426286935806,
-0.0803665816783905,
-0.12334161251783371,
-0.10801945626735687,
0.08831252157688141,
-0.10005895048379898,
0.3908692002296448,
-0.42490991950035095,
-0.017330847680568695,
-0.2275714874267578,
0.1660267412662506,
-0.3744141161441803,
-0.07633412629365921,
-0.28403282165527344,
0.1376211941242218,
0.02831760048866272,
0.061764396727085114,
-0.10150358825922012,
0.22421544790267944,
0.14303112030029297,
0.4614406228065491,
0.09928680956363678,
0.28121843934059143,
-0.18706081807613373,
0.08070635050535202,
0.021610502153635025,
0.2067512422800064,
0.2202160805463791,
0.10266837477684021,
-0.23370644450187683,
0.4200340211391449,
0.03553396835923195,
0.04843689873814583,
0.07848304510116577,
-0.09695558249950409,
-0.06034853681921959,
-0.051931802183389664,
0.17477940022945404,
-0.053855303674936295,
-0.04559290036559105,
-0.015810182318091393,
0.10942263156175613,
0.04506989195942879,
-0.14763961732387543,
-0.06265778094530106,
0.10443542897701263,
-0.12705571949481964,
-0.09014859050512314,
0.03537600487470627,
-0.07115014642477036,
0.0068626501597464085,
0.056486472487449646,
-0.22628414630889893,
-0.0662832111120224,
-0.05453765392303467,
0.12336304038763046,
-0.0724511593580246,
0.021669549867510796,
-0.03885018825531006,
0.08434908092021942,
0.20871703326702118,
-0.0826672613620758,
-0.04184123873710632,
-0.22186186909675598,
-0.07233171910047531,
-0.11619400978088379,
0.1676899939775467,
0.18936890363693237,
-0.09516957402229309,
-0.07525650411844254,
-0.11859480291604996,
0.03757670894265175,
-0.033303048461675644,
-0.031014462932944298,
-0.11866605281829834,
-0.39261165261268616,
-0.022364981472492218,
0.029865751042962074,
0.10039299726486206,
-0.02397671528160572,
0.029859649017453194,
0.014166885986924171,
0.2931880056858063,
-0.0855599120259285,
0.28702136874198914,
0.0776466503739357,
0.1302352398633957,
-0.23931151628494263,
0.16801545023918152,
0.14920471608638763,
-0.10159020870923996,
0.42844003438949585,
-0.05740392953157425,
0.03020002320408821,
-0.032078422605991364,
-0.04402439668774605,
-0.08513934165239334,
-0.22376854717731476,
-0.07012175023555756,
0.27309125661849976,
-0.274036169052124,
0.157382994890213,
-0.17290328443050385,
-0.19342081248760223,
-0.2373277097940445,
0.11499346047639847,
0.00912007037550211,
-0.05377032607793808,
0.11763989925384521,
0.0737953633069992,
-0.19477622210979462,
0.02392234466969967,
-0.041863441467285156,
0.30129706859588623,
0.16703929007053375,
-0.208242267370224,
-0.2301563322544098,
0.34426596760749817,
-0.1287684142589569,
0.17808857560157776,
-0.2921604812145233,
-0.14023321866989136,
0.06317318975925446,
-0.07076513767242432,
-0.19915460050106049,
0.17925739288330078,
0.14197584986686707,
-0.006172291934490204,
-0.12168028205633163,
-0.020698871463537216,
0.20561808347702026,
-0.331635981798172,
0.10944673418998718,
0.31148234009742737,
-0.21512682735919952,
-0.28323841094970703,
0.06964215636253357,
0.12821733951568604,
0.045263778418302536,
-0.031639277935028076,
0.40199732780456543,
0.21476392447948456,
0.3935970962047577,
0.12273743748664856,
-0.21608512103557587,
-0.19487328827381134,
0.0030412047635763884,
0.1498570293188095,
-0.23901218175888062,
-0.34089893102645874,
-0.09418386965990067,
0.3045218884944916,
0.06940608471632004,
0.15597595274448395,
-0.11348192393779755,
0.06991726160049438,
0.15906955301761627,
0.1078735962510109,
0.03067207708954811,
0.20968250930309296,
0.04801652207970619,
0.06120571494102478,
-0.15300987660884857,
0.08518420904874802,
0.307623952627182,
0.3098403811454773,
-0.31445902585983276,
0.12310515344142914,
0.060732245445251465,
-0.10439621657133102,
-0.03481212258338928,
-0.01624867506325245,
-0.03646579012274742,
-0.12267594039440155,
0.09457175433635712,
0.28347349166870117,
-0.11799778044223785,
-0.03287944942712784,
0.18481963872909546,
-0.18105202913284302,
0.004725195467472076,
0.348615825176239,
-0.10185553133487701,
-0.009213306941092014,
0.1867622435092926,
-0.07007052004337311,
0.1833743453025818,
-0.027785994112491608,
0.0031918322201818228,
-0.17074771225452423,
0.009341719560325146,
0.23603223264217377,
0.14794017374515533,
0.22589616477489471,
-0.19090768694877625,
0.06486530601978302,
0.020928729325532913,
-0.000671941030304879,
0.35134509205818176,
0.057667165994644165,
-0.10757634788751602,
0.0037632205057889223,
0.05350236967206001,
0.06703697890043259,
-0.011869622394442558,
-0.09790579974651337,
-0.17705877125263214,
0.434161514043808,
0.0475662425160408,
-0.046414297074079514,
-0.022814540192484856,
0.013018457219004631,
-0.10300369560718536,
-0.055812716484069824,
0.08817586302757263,
-0.09153324365615845,
-0.03597066551446915,
0.017948366701602936,
0.04722316563129425,
-0.027003392577171326,
-0.09459301084280014,
-0.34397146105766296,
-0.08091524988412857,
-0.021070197224617004,
-0.00777070876210928,
0.13174913823604584,
-0.04371260106563568,
0.15869611501693726,
-0.24408428370952606,
-0.16699571907520294,
0.040598947554826736,
-0.20316553115844727,
-0.14255425333976746,
-0.3504529893398285,
0.24903234839439392,
-0.03479980304837227,
0.2752467691898346,
0.07464609295129776,
-0.13754664361476898,
0.17949622869491577,
-0.10805340856313705,
0.10683335363864899,
-0.17070919275283813,
-0.06499791145324707,
-0.23514361679553986,
-0.1322803944349289,
-0.3796384930610657,
0.10107351094484329,
0.18891429901123047,
-0.07261698693037033,
0.23293304443359375,
0.16940633952617645,
0.008568555116653442,
-0.3594616651535034,
0.13902445137500763,
0.3092639744281769,
-0.16605493426322937,
0.15894941985607147,
-0.1644899994134903,
-0.4178556203842163,
0.13011091947555542,
0.2214864045381546,
0.15073023736476898,
-0.05944300815463066,
-0.19502253830432892,
0.010570574551820755,
-0.3134365677833557,
0.2202761322259903,
-0.05639725923538208,
-0.08198932558298111,
0.0780370682477951,
-0.09011128544807434,
-0.13798080384731293,
0.2201344221830368,
-0.051662713289260864,
-0.060500338673591614,
0.03696956858038902,
-0.3373451828956604,
-0.26847875118255615,
0.059815648943185806,
0.08134116977453232,
0.07079169154167175,
0.17695175111293793,
0.19037684798240662,
0.05854241922497749,
-0.03298573940992355,
-0.04363752156496048,
0.09240265935659409,
0.11682099103927612,
0.5215574502944946,
-0.3116050362586975,
-0.02807522378861904,
-0.0591207817196846,
-0.07822285592556,
-0.03724624216556549,
-0.2910963296890259,
-0.1543135941028595,
0.006605513393878937,
0.09641914069652557,
-0.22702425718307495,
0.2649476230144501,
-0.018637707456946373,
0.1272437572479248,
-0.1659807562828064,
-0.18939168751239777,
-0.05515014007687569,
-0.09631354361772537,
-0.005322768818587065,
-0.10796621441841125,
0.23454764485359192,
0.2598130702972412,
-0.20474442839622498,
-0.2698625326156616,
-0.16896943747997284,
-0.053448162972927094,
0.23239988088607788,
-0.055741701275110245,
0.19265559315681458,
-0.09731362760066986,
-0.08477765321731567,
0.2261648327112198,
0.18487505614757538,
0.28613853454589844,
0.04376577213406563,
-0.10337409377098083,
0.046922530978918076,
0.18357394635677338,
0.04276636987924576,
0.028886957094073296,
0.22355212271213531,
0.04077903926372528,
0.03251353278756142,
0.07912366092205048,
-0.09371908009052277,
0.13175702095031738,
0.16682681441307068,
-0.19513627886772156,
-0.015963003039360046,
-0.13259278237819672,
0.08066762238740921,
-0.13696123659610748,
0.13342225551605225,
0.2604668438434601,
-0.049767836928367615,
0.1728152483701706,
0.07749488204717636,
-0.2001757174730301,
0.17146173119544983,
0.05483626574277878,
-0.07218874245882034,
-0.11152517050504684,
0.09714798629283905,
0.1891099065542221,
-0.1575503647327423,
-0.0231950543820858,
0.08497848361730576,
-0.09908302873373032,
0.2683388590812683,
-0.12069199979305267,
0.20506063103675842,
0.21416005492210388,
-0.05400485917925835,
0.2704085409641266,
-0.01665887050330639,
0.06808042526245117,
0.22737586498260498,
0.04485040903091431,
-0.21130427718162537,
0.3591984212398529,
-0.1876981109380722,
0.11282806843519211,
-0.053935639560222626,
0.06672166287899017,
0.476861834526062,
0.014612351544201374,
-0.016513919457793236,
0.19153396785259247,
0.10807736963033676,
-0.0034393351525068283,
0.027295799925923347,
-0.07106591016054153,
0.10134594142436981,
0.24361132085323334,
-0.029158933088183403,
0.0025800110306590796,
0.016054827719926834,
0.023215636610984802,
-0.5579217672348022,
-0.16259121894836426,
0.09817520529031754,
-0.2399839162826538,
-0.2706809937953949,
0.040554847568273544,
-0.19221794605255127,
0.10535289347171783,
0.09649761766195297,
-0.16839158535003662,
0.0446765311062336,
0.1124228984117508,
-0.09696099162101746,
0.01445971243083477,
-0.061680082231760025,
0.15585017204284668,
0.0535423681139946,
0.08249132335186005,
-0.20664212107658386,
-0.2014937400817871,
0.25010916590690613,
-0.1969061940908432,
0.05609633028507233,
-0.20077595114707947,
-0.0251668319106102,
-0.026145363226532936,
-0.03785764425992966,
0.033998340368270874,
-0.04241442680358887,
-0.05602037534117699,
0.04730977490544319,
-0.09848413616418839,
0.13588517904281616,
-0.1450469046831131,
0.2375403642654419,
-0.014294059947133064,
0.1317637413740158,
-0.2064272165298462,
0.05004151538014412,
0.2113862931728363,
0.07411424815654755,
0.02917560376226902,
0.0989457368850708,
0.04037405923008919,
-0.08210908621549606,
0.06282422691583633,
-0.24449017643928528,
-0.11797807365655899,
0.04091084748506546,
-0.039657048881053925,
0.13546063005924225,
-0.06575074046850204,
0.4478973150253296,
-0.03613092377781868,
0.11912954598665237,
0.03626847267150879,
-0.06495998054742813,
0.02863476797938347,
0.17574357986450195,
0.3036234676837921,
-0.0021630669943988323,
-0.097401924431324,
0.16602490842342377,
0.033202823251485825,
-0.16415350139141083,
0.15617935359477997,
-0.2916044294834137,
-0.11184641718864441,
-0.08859942108392715,
-0.13310177624225616,
-0.14132371544837952,
-0.21427574753761292,
0.17118164896965027,
0.149004265666008,
-0.293573260307312,
-0.10875644534826279,
-0.30130013823509216,
0.10851693898439407,
0.35053473711013794,
-0.13929320871829987,
0.3792341947555542,
0.3446243405342102,
-0.010620455257594585,
0.04040918126702309,
-0.19156613945960999,
0.26483678817749023,
0.06815542280673981,
-0.02689441479742527,
-0.08387257158756256,
0.18057221174240112,
-0.0389399453997612,
0.04107556864619255,
0.05995814874768257,
0.07236001640558243,
0.048988230526447296,
-0.16011975705623627,
-0.08351369947195053,
-0.1172788217663765,
0.11276990175247192,
0.11846117675304413,
-0.16069483757019043,
0.3629920780658722,
0.05880138650536537,
-0.28431835770606995,
-0.21407371759414673,
0.16030162572860718,
-0.0031985421665012836,
0.11558760702610016,
-0.45558232069015503,
0.09421435743570328,
-0.0033184890635311604,
0.45532891154289246,
0.02339811995625496,
0.3053774833679199,
0.01098036952316761,
0.16315484046936035,
-0.1705603152513504,
-0.17972485721111298,
0.12225716561079025,
-0.16476145386695862,
-0.14763368666172028,
0.10928001999855042,
0.1353643834590912,
-0.04976844787597656,
0.09281503409147263,
-0.10739482194185257,
0.14320506155490875,
0.05267370864748955,
0.23034252226352692,
0.04143380746245384,
-0.38800016045570374,
0.02503967471420765,
-0.08357594162225723,
-0.041770994663238525,
0.11392899602651596,
0.07245290279388428,
0.11366260051727295,
-0.39737242460250854,
0.22965671122074127,
-0.01936594396829605,
0.010086385533213615,
-0.25716397166252136,
-0.4202834367752075,
-0.2904874384403229,
0.1081152856349945,
0.14531651139259338,
0.028938578441739082,
0.15778976678848267,
-0.17369745671749115,
0.18676644563674927,
0.013101670891046524,
0.0926850363612175,
0.1780196726322174,
-0.1669863909482956,
0.013189494609832764,
-0.03674890846014023,
-0.08402721583843231,
0.19582599401474,
0.11828886717557907,
-0.06376087665557861,
0.23519104719161987,
-0.30172982811927795,
-0.10935527086257935,
-0.36982113122940063,
0.2196168154478073,
0.13501079380512238,
-0.014263936318457127,
0.16295631229877472,
0.058596521615982056,
0.03759225457906723,
-0.14009007811546326,
0.1679016649723053,
0.3850712776184082,
-0.05989549309015274,
-0.3186497390270233,
-0.21078769862651825,
-0.25661057233810425,
0.17381642758846283,
-0.031021054834127426,
-0.09462561458349228,
-0.022342219948768616,
0.27371761202812195,
-0.14729247987270355,
0.08757495880126953,
0.0013160774251446128,
-0.06027751415967941,
-0.018316760659217834,
-0.07292336970567703,
-0.2347225546836853,
0.4976380467414856,
-0.2003055065870285,
-0.09663984924554825,
0.06387029588222504,
-0.12376733869314194,
0.06860781461000443,
0.2638731598854065,
0.03338108956813812,
0.026690296828746796,
-0.1664549559354782,
0.15764985978603363,
-0.46342918276786804,
0.1248437687754631,
-0.1652415245771408,
0.12357883900403976,
-0.27771079540252686,
-0.058231011033058167,
0.1853935271501541,
-0.06272771209478378,
0.36756035685539246,
-0.3278806209564209,
0.09486290067434311,
-0.11706949025392532,
0.09294700622558594,
0.012766754254698753,
-0.021459456533193588,
0.11893434077501297,
-0.09025328606367111,
0.3737702965736389,
-0.11889126896858215,
-0.049754876643419266,
-0.06815065443515778,
0.12582911550998688,
0.05413529649376869,
-0.08049987256526947,
-0.10495897382497787,
-0.20236599445343018,
0.21533961594104767,
0.2761794328689575,
-0.051027387380599976,
0.24809211492538452,
0.09435118734836578,
-0.1141672357916832,
-0.441766619682312,
-0.05864096060395241,
-0.018738286569714546,
0.09282698482275009,
0.02953796461224556,
0.1469055414199829,
-0.19721874594688416,
-0.16576696932315826,
-0.029784640297293663,
0.15423981845378876,
-0.094281405210495,
0.051671192049980164,
-0.05617016926407814,
0.025495577603578568,
0.1749695986509323,
-0.26552456617355347,
-0.29821833968162537,
-0.3043118715286255,
-0.006122761406004429,
-0.1591532677412033,
0.16000942885875702,
-0.28591087460517883,
-0.2726030945777893,
-0.005251026712357998,
0.1178615465760231,
-0.21198543906211853,
0.2656620740890503,
0.1590542197227478,
0.501664400100708
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. .Diagnosis/testing.The diagnosis of Proteus syndrome is based on clinical criteria that include all three general characteristics (mosaic distribution of lesions, sporadic occurrence, progressive course) and additional specific clinical criteria. Identification of a mosaic, somatic, heterozygous pathogenic variant in AKT1 by molecular genetic testing can establish the diagnosis if the clinical criteria are inconclusive.Management.Treatment of manifestations: Management of overgrowth is the chief concern; the approaches are diverse and include various orthopedic procedures to delay or halt linear bone growth; rehabilitation medicine care including physical and occupational therapy; correction of skeletal deformities such as scoliosis; dermatologic management of the skin manifestations, especially the cerebriform connective tissue nevi with pedorthic intervention as needed; monitoring for and treating deep vein thrombosis and pulmonary embolism; monitoring and treating bullous pulmonary disease; developmental intervention or special education for developmental delays; psychosocial counseling is warranted in most instances.Surveillance: Monitoring should be tailored to individual presentation; routine monitoring for evidence of tumor development is by medical history | [
-0.06602969020605087,
-0.09723739326000214,
-0.0604647733271122,
-0.34514763951301575,
0.05869914963841438,
-0.038653768599033356,
-0.11675197631120682,
-0.27466127276420593,
0.028044328093528748,
0.13762395083904266,
0.16391105949878693,
0.16944590210914612,
-0.01615871489048004,
-0.027258433401584625,
-0.30683204531669617,
0.3610430955886841,
0.06936992704868317,
0.04197978600859642,
0.05324137210845947,
0.12820757925510406,
-0.008832077495753765,
-0.08091802150011063,
-0.14493481814861298,
0.06297677010297775,
0.011968087404966354,
-0.18962296843528748,
0.14267587661743164,
0.01465347595512867,
-0.0874817743897438,
-0.1486261487007141,
-0.029754022136330605,
-0.0498216487467289,
-0.21348215639591217,
-0.381966769695282,
-0.007433920633047819,
-0.35920363664627075,
-0.346636027097702,
-0.07034361362457275,
0.12176142632961273,
-0.024765267968177795,
-0.08353102207183838,
-0.05648503452539444,
-0.04859839752316475,
-0.23406368494033813,
0.3448672592639923,
-0.07938126474618912,
0.10699335485696793,
0.08857905119657516,
0.08365112543106079,
0.2504448890686035,
0.20254965126514435,
0.03729921951889992,
0.11803010106086731,
-0.10712971538305283,
0.13586068153381348,
-0.15443968772888184,
0.045756082981824875,
-0.165532648563385,
-0.472251296043396,
0.06489648669958115,
0.37985801696777344,
0.14723023772239685,
0.02738196961581707,
-0.4755678176879883,
0.01179785281419754,
-0.18249905109405518,
-0.08115414530038834,
0.023281801491975784,
0.16899704933166504,
-0.0845445990562439,
0.3816046714782715,
-0.12270557135343552,
-0.05185128003358841,
-0.058777786791324615,
-0.06971261650323868,
-0.169511079788208,
0.1544031798839569,
-0.08286768198013306,
-0.011369245126843452,
-0.27609118819236755,
-0.15786413848400116,
-0.24998675286769867,
-0.26703041791915894,
0.09647119045257568,
-0.3421938121318817,
-0.12856723368167877,
-0.17075179517269135,
-0.02354421839118004,
0.10054534673690796,
0.03183154761791229,
0.16510911285877228,
0.03756880760192871,
0.06820196658372879,
0.28877851366996765,
0.07061738520860672,
0.0070415581576526165,
0.2701666057109833,
0.055806964635849,
-0.23407556116580963,
-0.159323588013649,
0.13365836441516876,
0.445205956697464,
-0.0030586658976972103,
-0.09442952275276184,
0.12605006992816925,
-0.09010282158851624,
-0.16325728595256805,
-0.11468642950057983,
0.1053340956568718,
-0.10846275091171265,
0.0014030026504769921,
-0.08056138455867767,
0.03804205730557442,
-0.029272830113768578,
-0.29324451088905334,
-0.19687709212303162,
0.011593650095164776,
0.15539909899234772,
-0.19758668541908264,
-0.1090766191482544,
-0.045505721122026443,
-0.051060426980257034,
-0.052516426891088486,
-0.1635599285364151,
0.11297034472227097,
0.04132726788520813,
0.3020901083946228,
-0.35536202788352966,
-0.010967915877699852,
-0.16148415207862854,
0.1996006816625595,
-0.24655704200267792,
-0.19083793461322784,
-0.4035971760749817,
0.03749549016356468,
0.0930057093501091,
-0.034905996173620224,
-0.1410135179758072,
0.08359942585229874,
0.1497606784105301,
0.2093672752380371,
0.13855300843715668,
0.39035314321517944,
-0.024448275566101074,
0.016297446563839912,
0.05394013971090317,
0.29312682151794434,
0.1520538479089737,
-0.05165305361151695,
-0.1754935383796692,
0.34099093079566956,
-0.09158574789762497,
0.2488034963607788,
0.11420512944459915,
0.07596546411514282,
-0.10107212513685226,
-0.10007058829069138,
0.2971135675907135,
-0.12236078828573227,
0.012691359035670757,
0.008429975248873234,
-0.015266770496964455,
-0.005193426739424467,
-0.18039800226688385,
-0.04896773397922516,
0.11731292307376862,
-0.05917075276374817,
-0.16747097671031952,
0.046775639057159424,
-0.13275758922100067,
-0.22287799417972565,
0.09821627289056778,
-0.167737677693367,
0.19546136260032654,
0.08398421108722687,
0.12051692605018616,
0.13202746212482452,
0.12856028974056244,
-0.09133465588092804,
0.16433607041835785,
0.23433613777160645,
-0.20259487628936768,
-0.04944603890180588,
-0.135561004281044,
0.09557313472032547,
-0.21232594549655914,
0.1391787976026535,
0.2774543762207031,
-0.22132782638072968,
0.02321637235581875,
-0.07421443611383438,
-0.042537540197372437,
-0.1908046454191208,
-0.053713101893663406,
-0.07044734805822372,
-0.3206283152103424,
0.0035329866223037243,
-0.023210886865854263,
0.13028226792812347,
-0.02630840800702572,
0.06597299128770828,
-0.0017075283685699105,
0.23206426203250885,
-0.10948873311281204,
0.16168446838855743,
0.10635390877723694,
0.21064506471157074,
-0.34718576073646545,
0.08852662891149521,
0.15769582986831665,
-0.13740107417106628,
0.4737028479576111,
-0.08738850802183151,
-0.0038993835914880037,
0.020616088062524796,
-0.13413862884044647,
-0.14595219492912292,
-0.26061031222343445,
-0.23753586411476135,
0.35048335790634155,
-0.3179444670677185,
0.16043423116207123,
-0.025233203545212746,
-0.19240333139896393,
-0.3114292025566101,
0.08296890556812286,
-0.08144401013851166,
-0.1153007224202156,
0.06077101081609726,
0.01628750003874302,
-0.07433658838272095,
-0.027645129710435867,
-0.09330461919307709,
0.16168899834156036,
0.1721026450395584,
-0.3159782588481903,
-0.3209865689277649,
0.3107577860355377,
0.036713894456624985,
0.05063997954130173,
-0.13917997479438782,
-0.04672893136739731,
0.14178676903247833,
-0.13034293055534363,
-0.21691776812076569,
0.15349005162715912,
0.1682671308517456,
0.23611891269683838,
-0.19136852025985718,
0.02033662050962448,
0.159727081656456,
-0.234884113073349,
0.10310182720422745,
0.2240985631942749,
-0.14215871691703796,
-0.1919223517179489,
-0.03812339901924133,
0.09302811324596405,
0.1802036315202713,
-0.02368765138089657,
0.29616501927375793,
0.17897304892539978,
0.43370434641838074,
-0.04881439357995987,
-0.29121729731559753,
-0.22543048858642578,
-0.012795594520866871,
0.2178996056318283,
-0.1499859094619751,
-0.32054030895233154,
-0.14861728250980377,
0.25103670358657837,
0.05634903535246849,
0.1988612562417984,
-0.15243549644947052,
0.0734935775399208,
0.050366297364234924,
0.20776115357875824,
0.06949537247419357,
0.15833161771297455,
0.15085762739181519,
-0.029943358153104782,
-0.17916490137577057,
0.0069568264298141,
0.35178202390670776,
0.22658340632915497,
-0.28163307905197144,
0.21891604363918304,
0.027589211240410805,
-0.09093240648508072,
0.06878183037042618,
0.100367970764637,
0.0400688610970974,
-0.15353482961654663,
0.08479192852973938,
0.21373844146728516,
0.07214910537004471,
0.16231922805309296,
0.19006000459194183,
-0.12347085773944855,
0.054545313119888306,
0.16051526367664337,
-0.13211689889431,
0.04273113235831261,
0.13962756097316742,
-0.25666916370391846,
0.33219292759895325,
-0.08927183598279953,
0.17036990821361542,
-0.13330094516277313,
0.02947612665593624,
0.2614316940307617,
0.0645003691315651,
0.1653640866279602,
-0.18713797628879547,
0.05252475291490555,
-0.11844009906053543,
0.04919549077749252,
0.3151808977127075,
0.06826397776603699,
-0.003087796038016677,
0.03980303555727005,
0.10733050107955933,
0.07803797721862793,
-0.06905122101306915,
0.03821338340640068,
-0.16005761921405792,
0.28748974204063416,
0.010557389818131924,
-0.06481797248125076,
-0.16298098862171173,
0.04141749069094658,
-0.08349113166332245,
-0.1693940907716751,
0.0770404189825058,
-0.2342018038034439,
0.08995356410741806,
0.06873791664838791,
0.15200497210025787,
-0.12185446918010712,
0.04907267540693283,
-0.3252703547477722,
-0.04477157071232796,
-0.13317643105983734,
-0.011922160163521767,
0.1728646457195282,
-0.11859754472970963,
0.011132651008665562,
-0.1141512393951416,
-0.1296771764755249,
0.06497092545032501,
-0.17508022487163544,
-0.0035083203110843897,
-0.37175819277763367,
0.2727130949497223,
-0.014972313307225704,
0.1489957720041275,
0.1390678435564041,
-0.04049995169043541,
0.10964997857809067,
-0.19761306047439575,
0.06677475571632385,
-0.06249381601810455,
-0.1177111491560936,
-0.025751853361725807,
-0.18796448409557343,
-0.34849223494529724,
0.16657838225364685,
0.27377328276634216,
0.016168970614671707,
0.3895537555217743,
0.004744784440845251,
0.011932981200516224,
-0.08896003663539886,
0.13302870094776154,
0.14420753717422485,
-0.19600491225719452,
0.06831346452236176,
-0.11349133402109146,
-0.4312257170677185,
0.15773017704486847,
0.22210967540740967,
0.1649557501077652,
-0.08720176666975021,
-0.2621401250362396,
0.018990574404597282,
-0.30679380893707275,
0.24042098224163055,
-0.059736303985118866,
-0.19803479313850403,
0.17909976840019226,
-0.12759849429130554,
-0.006459043361246586,
0.23573993146419525,
-0.051088303327560425,
-0.08432168513536453,
0.17358562350273132,
-0.25718915462493896,
-0.2292928844690323,
-0.057648684829473495,
0.0546346977353096,
0.04142729192972183,
0.22454579174518585,
0.1980588138103485,
-0.039889801293611526,
-0.20042060315608978,
-0.05594566464424133,
0.08412900567054749,
0.02706068381667137,
0.40448060631752014,
-0.26253172755241394,
-0.12629587948322296,
-0.04068254679441452,
-0.0726584792137146,
0.1298770010471344,
-0.030791310593485832,
-0.07239191979169846,
-0.03952227160334587,
0.08400522917509079,
-0.18155275285243988,
0.12606655061244965,
-0.11907795816659927,
0.08736926317214966,
-0.10756555199623108,
-0.2124074399471283,
-0.030986163765192032,
-0.14695295691490173,
0.05087130889296532,
-0.12270776182413101,
0.19405697286128998,
0.3030812740325928,
-0.12362011522054672,
-0.23265159130096436,
0.08979131281375885,
-0.09634196758270264,
0.18362590670585632,
0.016429075971245766,
0.1521386355161667,
0.008965514600276947,
-0.09262800216674805,
0.23254220187664032,
-0.022578023374080658,
0.2920146584510803,
0.043244924396276474,
0.0003226344706490636,
0.007827958092093468,
0.0335298590362072,
0.14799173176288605,
0.05863495543599129,
0.02003103494644165,
0.015137726441025734,
0.024761348962783813,
0.1101999282836914,
-0.032564304769039154,
0.05240907520055771,
0.18974128365516663,
-0.1816829890012741,
-0.04075782373547554,
-0.13020145893096924,
0.06308313459157944,
-0.16683760285377502,
0.053522225469350815,
0.21443575620651245,
-0.016841357573866844,
0.08402911573648453,
0.19507011771202087,
-0.29949796199798584,
0.1527191400527954,
0.15974396467208862,
-0.008640863932669163,
0.005769208073616028,
0.1466752141714096,
0.1378841996192932,
0.04589615389704704,
-0.09808919578790665,
-0.07495899498462677,
0.07641921192407608,
0.07708116620779037,
-0.05838610231876373,
0.1446235179901123,
0.18751007318496704,
-0.06822589784860611,
0.19332967698574066,
0.14510224759578705,
0.12703321874141693,
0.20339970290660858,
0.05042700096964836,
-0.10855164378881454,
0.19717039167881012,
-0.26751264929771423,
0.12180804461240768,
-0.14349490404129028,
0.03447304293513298,
0.4519657790660858,
0.0485137477517128,
-0.05378933250904083,
0.07498636096715927,
0.09054472297430038,
-0.041795115917921066,
-0.07082682847976685,
0.16388291120529175,
0.1702963411808014,
0.13663825392723083,
-0.01409660279750824,
-0.07291118800640106,
-0.11800119280815125,
0.027081400156021118,
-0.4077111482620239,
-0.32982444763183594,
0.08200915902853012,
-0.28450363874435425,
-0.11596813052892685,
-0.0747925341129303,
-0.11564449965953827,
0.04098530486226082,
-0.016649959608912468,
-0.05499321594834328,
-0.009767978452146053,
0.04270656034350395,
0.027009805664420128,
0.019597599282860756,
-0.001245149876922369,
-0.025058390572667122,
-0.019164366647601128,
0.06557080149650574,
-0.10768655687570572,
0.052859507501125336,
0.1762576550245285,
-0.18300847709178925,
-0.09605928510427475,
-0.1637200266122818,
-0.17006142437458038,
0.055581338703632355,
-0.005556867457926273,
0.07097839564085007,
-0.12251845747232437,
-0.20706866681575775,
0.001026818878017366,
-0.21112340688705444,
0.21249304711818695,
-0.28967511653900146,
0.19610066711902618,
0.20575471222400665,
0.05732130631804466,
-0.09616249799728394,
0.10266774892807007,
0.2708462178707123,
0.06431150436401367,
0.07530674338340759,
0.2697461247444153,
0.030629420652985573,
-0.12592802941799164,
0.06260707974433899,
-0.20963361859321594,
-0.17447951436042786,
0.04436875134706497,
0.13450023531913757,
0.08367250859737396,
-0.09106960147619247,
0.38672202825546265,
0.000612091098446399,
0.06772305816411972,
0.07640482485294342,
-0.06356755644083023,
0.09498059004545212,
0.1862083077430725,
0.23856157064437866,
-0.10537713021039963,
-0.06111835315823555,
0.03404140844941139,
0.09909477829933167,
-0.09041271358728409,
0.12449910491704941,
-0.26692497730255127,
-0.11242736130952835,
0.07439209520816803,
-0.029108356684446335,
-0.08511564135551453,
-0.2870193421840668,
0.23401540517807007,
0.34289857745170593,
-0.2349451333284378,
-0.1986398696899414,
-0.4196290969848633,
0.10325866937637329,
0.30422064661979675,
-0.12369440495967865,
0.26815709471702576,
0.3051931858062744,
-0.05633942037820816,
0.019715821370482445,
-0.10768087953329086,
0.15263846516609192,
-0.0390494167804718,
0.0466398224234581,
-0.1451766937971115,
0.2668013870716095,
0.025766568258404732,
0.08164357393980026,
0.046510614454746246,
0.07573700696229935,
0.0556681789457798,
-0.15922556817531586,
-0.07542569935321808,
-0.005826266016811132,
0.0022539831697940826,
0.06255541741847992,
-0.19735583662986755,
0.12881562113761902,
0.04851255565881729,
-0.20150142908096313,
-0.09823820739984512,
0.09046106040477753,
-0.010739026591181755,
0.20811286568641663,
-0.3878587484359741,
0.09963829815387726,
-0.04137011244893074,
0.28691333532333374,
-0.0339638777077198,
0.30423346161842346,
0.05836723744869232,
0.056564122438430786,
-0.18095016479492188,
-0.1879098117351532,
0.07973664253950119,
-0.0017754562431946397,
-0.04759872332215309,
0.02704685553908348,
-0.04366147518157959,
-0.03243108466267586,
0.019367534667253494,
-0.1700735241174698,
0.07776166498661041,
-0.022774789482355118,
0.10103563964366913,
0.038226958364248276,
-0.18856078386306763,
-0.09879299253225327,
-0.08062651008367538,
-0.04658357426524162,
0.061437562108039856,
0.03466048091650009,
0.3013726770877838,
-0.33840808272361755,
0.027156764641404152,
-0.05193832144141197,
-0.11221855878829956,
-0.19598141312599182,
-0.2736860513687134,
-0.19688576459884644,
0.1450856775045395,
0.07575850188732147,
-0.0036120677832514048,
0.2718842625617981,
-0.17682470381259918,
0.2899499833583832,
0.07533719390630722,
0.10504450649023056,
0.040162645280361176,
-0.051491815596818924,
0.08505977690219879,
-0.04242542386054993,
0.08926451951265335,
0.17923207581043243,
0.13329379260540009,
-0.12281692028045654,
0.131279855966568,
-0.2683824300765991,
-0.14024172723293304,
-0.34510377049446106,
0.27520978450775146,
0.01732882671058178,
-0.038451384752988815,
0.010774781927466393,
-0.0012032106751576066,
0.18535824120044708,
-0.243071049451828,
0.0007339848671108484,
0.2608477771282196,
0.10939587652683258,
-0.2948544919490814,
-0.1623440533876419,
-0.224472314119339,
0.23420576751232147,
-0.11941372603178024,
-0.07416693866252899,
-0.00909610278904438,
0.1227051317691803,
-0.10720591247081757,
0.04350220412015915,
-0.09708818048238754,
0.01326574943959713,
-0.05052682012319565,
-0.13887852430343628,
-0.22515864670276642,
0.5157389640808105,
-0.1582179069519043,
-0.1255573332309723,
-0.07943976670503616,
-0.03834488242864609,
0.05639224871993065,
-0.03438284248113632,
-0.006607367191463709,
0.04945428669452667,
-0.11018736660480499,
0.08336720615625381,
-0.1550077646970749,
0.11806845664978027,
-0.11473755538463593,
-0.025216711685061455,
-0.15344426035881042,
-0.1605491042137146,
0.16581113636493683,
-0.1657050997018814,
0.2765812277793884,
-0.2861543297767639,
0.12261941283941269,
-0.019093425944447517,
-0.013804048299789429,
0.036278869956731796,
0.14718535542488098,
0.12265008687973022,
-0.07684597373008728,
0.22754360735416412,
-0.07744502276182175,
0.07623375952243805,
0.001302940072491765,
0.12276633083820343,
0.032553113996982574,
-0.05154063180088997,
-0.14041535556316376,
-0.31462547183036804,
0.12994806468486786,
0.00020135653903707862,
-0.024522019550204277,
0.25194883346557617,
-0.11269940435886383,
-0.07004262506961823,
-0.3554718792438507,
0.04443562030792236,
-0.038276318460702896,
0.014109068550169468,
-0.028693117201328278,
0.10893485695123672,
-0.13605177402496338,
0.030614502727985382,
-0.04579617455601692,
0.04059845954179764,
-0.12347925454378128,
-0.04178715497255325,
0.017026862129569054,
0.11404073983430862,
0.1885550618171692,
-0.24746175110340118,
-0.22689403593540192,
-0.3642086386680603,
-0.07100572437047958,
0.020425552502274513,
0.18409433960914612,
-0.1494150012731552,
-0.1842186152935028,
-0.10729727894067764,
0.02274741791188717,
-0.24927660822868347,
0.2663818299770355,
0.07723992317914963,
0.20706790685653687
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. linear bone growth; rehabilitation medicine care including physical and occupational therapy; correction of skeletal deformities such as scoliosis; dermatologic management of the skin manifestations, especially the cerebriform connective tissue nevi with pedorthic intervention as needed; monitoring for and treating deep vein thrombosis and pulmonary embolism; monitoring and treating bullous pulmonary disease; developmental intervention or special education for developmental delays; psychosocial counseling is warranted in most instances.Surveillance: Monitoring should be tailored to individual presentation; routine monitoring for evidence of tumor development is by medical history and physical examination; periodic imaging is not indicated.Agents/circumstances to avoid: Medications that increase the risk of deep vein thrombosis or are procoagulant; medications that increase growth (e.g., androgenic steroids or growth hormone).Genetic counseling.All individuals with clinically confirmed Proteus syndrome known to these authors have been simplex occurrences caused by somatic mosaicism for the specific de novo pathogenic variant c.49G>A (p.Glu17Lys). It is hypothesized | [
-0.19915300607681274,
-0.013577737845480442,
-0.005432565696537495,
-0.2900286614894867,
0.12845706939697266,
0.01602932997047901,
-0.05818895995616913,
-0.16581706702709198,
-0.22815406322479248,
-0.175394669175148,
0.1024639829993248,
0.08728933334350586,
-0.09643859416246414,
0.09912724792957306,
-0.2825455069541931,
0.49128395318984985,
-0.15109039843082428,
0.18678751587867737,
0.07431340962648392,
0.042323555797338486,
-0.02776215597987175,
-0.1743454784154892,
-0.07533889263868332,
0.13937824964523315,
-0.10869299620389938,
-0.05257045105099678,
0.20345033705234528,
0.016999879851937294,
-0.06329956650733948,
-0.033079735934734344,
-0.0557670071721077,
-0.06362812221050262,
-0.08241798728704453,
-0.4586505889892578,
-0.15128296613693237,
-0.29793938994407654,
-0.24503907561302185,
0.013684392906725407,
0.11218034476041794,
0.06802424788475037,
-0.03922676667571068,
-0.040709443390369415,
-0.06454064697027206,
-0.10325337201356888,
0.12496090680360794,
-0.04893016815185547,
0.10734913498163223,
0.24876298010349274,
0.04037969559431076,
0.16797029972076416,
-0.017485707998275757,
-0.09262093156576157,
0.09292473644018173,
-0.09293021261692047,
0.059610962867736816,
-0.12656664848327637,
-0.023484840989112854,
-0.02670278213918209,
-0.2937338650226593,
-0.024844154715538025,
0.28144538402557373,
0.03619384765625,
-0.01944819651544094,
-0.367112398147583,
0.09304163604974747,
-0.15791259706020355,
-0.011432678438723087,
0.04844751954078674,
0.07356132566928864,
0.03961429372429848,
0.35558682680130005,
-0.24400895833969116,
-0.039247091859579086,
0.02859549969434738,
0.10116026550531387,
-0.01496999803930521,
0.07569059729576111,
-0.03803248330950737,
-0.025228535756468773,
-0.07429720461368561,
-0.11364564299583435,
-0.05008317157626152,
-0.1861414909362793,
0.012073888443410397,
-0.2778377830982208,
-0.21107105910778046,
-0.15340691804885864,
0.08467619121074677,
-0.08889275789260864,
-0.053800247609615326,
0.07190527766942978,
0.09316308051347733,
0.10646899044513702,
0.089287668466568,
0.12073512375354767,
-0.03354980796575546,
-0.01665933057665825,
0.16769523918628693,
-0.17614391446113586,
-0.033687420189380646,
0.20439712703227997,
0.26906511187553406,
-0.2355373352766037,
-0.07913248240947723,
0.017747847363352776,
-0.08358141034841537,
-0.1138329729437828,
0.02161891758441925,
0.053618721663951874,
-0.0283387191593647,
0.008807084523141384,
-0.053339067846536636,
0.1682690680027008,
0.0016329992795363069,
-0.27144500613212585,
-0.16598843038082123,
0.05466853454709053,
0.09720825403928757,
-0.06652306765317917,
-0.14556585252285004,
-0.15783661603927612,
-0.04528973624110222,
-0.12017755210399628,
-0.16127082705497742,
0.12544046342372894,
0.05684204027056694,
0.2773708403110504,
-0.21239085495471954,
0.04170284420251846,
-0.18739360570907593,
0.19282197952270508,
-0.21078376471996307,
-0.0747755914926529,
-0.292479932308197,
-0.021694106981158257,
-0.028861772269010544,
0.08156070113182068,
-0.17020772397518158,
0.08995014429092407,
0.20263908803462982,
0.26469340920448303,
0.10806003212928772,
0.34106582403182983,
0.09111683070659637,
0.025115033611655235,
0.036137159913778305,
0.3326815962791443,
0.1545664519071579,
0.047683216631412506,
-0.08445946872234344,
0.23213684558868408,
-0.0679369866847992,
0.10856831818819046,
0.10757943987846375,
0.0663265585899353,
-0.16232062876224518,
-0.2173500955104828,
0.16647611558437347,
-0.1604653298854828,
0.05971427634358406,
0.08956382423639297,
-0.09006781131029129,
-0.052706848829984665,
-0.11807196587324142,
-0.11616900563240051,
0.1278214156627655,
0.047765254974365234,
-0.008892498910427094,
0.05557232350111008,
-0.12088898569345474,
-0.0749182179570198,
-0.013720134273171425,
0.014771757647395134,
-0.0031299034599214792,
0.056818004697561264,
0.005921589210629463,
0.1154409795999527,
0.0018442400032654405,
-0.10396885871887207,
0.1399560123682022,
0.08593389391899109,
-0.148465096950531,
-0.10355300456285477,
-0.15807104110717773,
0.02677352912724018,
-0.29839611053466797,
0.05075402930378914,
0.2946702539920807,
-0.18264713883399963,
0.01716405525803566,
0.034410614520311356,
0.07131626456975937,
-0.02906464785337448,
-0.10508204996585846,
-0.0404215008020401,
-0.30269908905029297,
-0.01708686724305153,
-0.1727607250213623,
0.051133979111909866,
0.09641563892364502,
0.07499486953020096,
0.08342690765857697,
0.06398608535528183,
-0.045463018119335175,
0.11407819390296936,
0.10340903699398041,
0.09107949584722519,
-0.25351905822753906,
0.08037111908197403,
-0.07899709790945053,
-0.03868473321199417,
0.332170695066452,
-0.027154790237545967,
-0.046405989676713943,
-0.009465265087783337,
-0.08823995292186737,
-0.16099701821804047,
-0.2928740382194519,
-0.14165185391902924,
0.19774208962917328,
-0.2130039781332016,
0.20545955002307892,
-0.1521029770374298,
-0.17756839096546173,
-0.2793715298175812,
0.13179466128349304,
0.04642104357481003,
-0.06484819948673248,
0.15666629374027252,
0.10734226554632187,
-0.09157287329435349,
0.18588900566101074,
-0.010623455978929996,
0.009981600567698479,
-0.015860540792346,
-0.3633614182472229,
-0.13274605572223663,
0.38353562355041504,
-0.009978331625461578,
0.11406432837247849,
-0.17001080513000488,
0.10425741970539093,
0.19005268812179565,
-0.012506227008998394,
-0.24099776148796082,
-0.03625916689634323,
0.06956770271062851,
0.09208790957927704,
-0.24808597564697266,
0.014970124699175358,
0.06586232036352158,
-0.3139094114303589,
0.09181194007396698,
0.162871852517128,
-0.17736351490020752,
-0.1113106906414032,
0.2131754457950592,
0.13485072553157806,
-0.0042661274783313274,
-0.10255809873342514,
0.20029595494270325,
0.08853807300329208,
0.23336204886436462,
-0.0872562974691391,
-0.28894150257110596,
-0.12372563779354095,
-0.05121408402919769,
0.15776289999485016,
-0.21142570674419403,
-0.30886945128440857,
-0.13060341775417328,
0.1436639428138733,
0.08967038244009018,
-0.041225615888834,
-0.21431463956832886,
0.07715246081352234,
0.014986417256295681,
0.11708404868841171,
-0.051119614392519,
0.2610047161579132,
0.13413479924201965,
0.08929730951786041,
-0.12327368557453156,
0.0025220790412276983,
0.24090974032878876,
0.1821882426738739,
-0.12479802221059799,
0.29239368438720703,
-0.001587978913448751,
-0.00028100929921492934,
-0.0069011300802230835,
0.09343478083610535,
0.0548987053334713,
-0.12037791311740875,
0.2035454511642456,
0.24578909575939178,
-0.027694029733538628,
0.07230640202760696,
0.049005959182977676,
-0.11388258635997772,
-0.028748929500579834,
0.15836015343666077,
-0.20982520282268524,
0.025838004425168037,
0.005557525437325239,
-0.21229493618011475,
0.04803302139043808,
0.110022634267807,
0.07296353578567505,
-0.049191076308488846,
0.037948932498693466,
0.22048558294773102,
0.11853551864624023,
0.06719624251127243,
-0.22685518860816956,
0.0036300395149737597,
-0.1985722780227661,
0.010537263937294483,
0.06620997935533524,
0.0009925831109285355,
0.07999399304389954,
-0.08254888653755188,
0.2612779140472412,
0.07970459759235382,
0.05597444251179695,
-0.06103995069861412,
-0.0688576027750969,
0.286081463098526,
-0.011867196299135685,
-0.0616583414375782,
-0.06623762845993042,
0.2068501114845276,
0.011764259077608585,
-0.0005777882179245353,
0.010227510705590248,
-0.004405375104397535,
0.02112475410103798,
0.058609433472156525,
0.0423533096909523,
-0.17272377014160156,
0.0011948326136916876,
-0.28103184700012207,
0.05723085254430771,
-0.046079136431217194,
-0.053871918469667435,
0.24768882989883423,
-0.015621453523635864,
0.08708129823207855,
-0.09381264448165894,
-0.14025823771953583,
-0.02418275736272335,
-0.25735947489738464,
0.11525231599807739,
-0.3579268753528595,
0.0809318944811821,
-0.058833956718444824,
-0.03584384173154831,
0.05375799164175987,
-0.08157457411289215,
0.09237208217382431,
-0.06915323436260223,
0.04815734550356865,
0.06942405551671982,
-0.1332390457391739,
0.10703025758266449,
-0.018758658319711685,
-0.28581345081329346,
-0.009809103794395924,
0.34010210633277893,
-0.044309280812740326,
0.24316230416297913,
0.10735920816659927,
-0.1063692718744278,
-0.07733478397130966,
0.10162203013896942,
0.17584702372550964,
-0.2958011031150818,
0.08318030089139938,
-0.15192873775959015,
-0.2767093777656555,
0.013188452459871769,
0.21263940632343292,
0.11396566033363342,
-0.031479544937610626,
-0.18518875539302826,
-0.035548411309719086,
-0.2737233340740204,
0.19205477833747864,
-0.235390767455101,
-0.08160477876663208,
0.011941088363528252,
-0.07884909957647324,
0.04224460944533348,
0.1629958599805832,
-0.21433381736278534,
-0.09532642364501953,
0.17659644782543182,
-0.16641855239868164,
-0.3729221224784851,
-0.04621036723256111,
0.03431408479809761,
-0.1670563817024231,
0.17652374505996704,
0.21696676313877106,
0.23063188791275024,
-0.08318448811769485,
-0.10135019570589066,
-0.022188428789377213,
-0.1266060620546341,
0.5458356142044067,
-0.20255887508392334,
-0.08147183060646057,
-0.0012019267305731773,
-0.05258052423596382,
0.05053303390741348,
-0.08759519457817078,
-0.04922007396817207,
0.04254251718521118,
0.07593407481908798,
-0.06773155182600021,
0.20170924067497253,
-0.028889767825603485,
-0.0016568532446399331,
-0.20494402945041656,
-0.30986735224723816,
0.014891502447426319,
-0.04591541737318039,
0.09057021141052246,
-0.0239904522895813,
0.18613386154174805,
0.41741660237312317,
0.09625370055437088,
-0.14455626904964447,
-0.03943437710404396,
-0.13732431828975677,
0.17638520896434784,
-0.02093670889735222,
0.16301067173480988,
0.06316888332366943,
-0.04474800080060959,
0.22004327178001404,
0.030283957719802856,
0.21858282387256622,
0.051130250096321106,
0.013401651754975319,
-0.01335611566901207,
0.0037372156511992216,
0.18230126798152924,
0.17242269217967987,
0.1218670979142189,
-0.05859064310789108,
-0.1400476098060608,
0.048940010368824005,
-0.1153852641582489,
-0.009199309162795544,
0.1910327970981598,
-0.07238785922527313,
-0.05172597989439964,
-0.11705507338047028,
0.18062621355056763,
-0.20786334574222565,
0.03372448310256004,
0.17288494110107422,
0.05359996110200882,
0.09932830184698105,
0.13529181480407715,
-0.3762402832508087,
0.002443019999191165,
0.13068585097789764,
-0.04027493670582771,
-0.04641825333237648,
0.01951107755303383,
0.05863235890865326,
0.020876191556453705,
-0.10735202580690384,
0.02191288396716118,
-0.09941282123327255,
0.2519194185733795,
-0.22498741745948792,
0.07775872945785522,
0.20249789953231812,
0.13073880970478058,
0.0965452790260315,
-0.10698410868644714,
0.07399029284715652,
0.08540651947259903,
0.1546231359243393,
-0.2054523080587387,
0.16044948995113373,
-0.061017971485853195,
0.07338456809520721,
-0.164306640625,
0.06130920350551605,
0.3667002320289612,
-0.12423103302717209,
-0.06422305852174759,
0.10559215396642685,
0.17672079801559448,
-0.034516382962465286,
-0.12531572580337524,
0.013602455146610737,
-0.02203499712049961,
0.04530489817261696,
0.08004935830831528,
0.10561726987361908,
-0.09748842567205429,
0.0228875782340765,
-0.3674558401107788,
-0.17505353689193726,
0.04786108434200287,
-0.10393884778022766,
-0.06067683920264244,
0.04328703507781029,
-0.14289484918117523,
0.015880124643445015,
0.13262787461280823,
0.011964762583374977,
0.029934752732515335,
0.04695180803537369,
-0.012601659633219242,
-0.008872045204043388,
-0.06004464253783226,
0.055631522089242935,
0.014437125995755196,
-0.07097141444683075,
-0.13406717777252197,
0.17827551066875458,
0.17473876476287842,
-0.22614845633506775,
-0.07430517673492432,
-0.0893576517701149,
-0.018320748582482338,
0.08073656260967255,
0.006213795859366655,
0.07817085832357407,
-0.11880051344633102,
-0.058641839772462845,
-0.02799672819674015,
-0.23612502217292786,
0.2159043848514557,
-0.007979127578437328,
0.02773536927998066,
0.22303245961666107,
0.20977765321731567,
0.002475438639521599,
0.10045967996120453,
0.2744831442832947,
0.10101786255836487,
0.12419502437114716,
0.19754479825496674,
0.16416466236114502,
0.02951306477189064,
-0.006025348324328661,
-0.28816837072372437,
-0.10705919563770294,
-0.08632632344961166,
0.2031528353691101,
0.10064475238323212,
0.06471724063158035,
0.2255174219608307,
0.0245728250592947,
0.0391988568007946,
0.16126640141010284,
0.013346451334655285,
-0.06289830803871155,
0.23701153695583344,
0.23986883461475372,
-0.14333322644233704,
-0.10674577951431274,
0.04322582855820656,
-0.002802572213113308,
-0.1398269534111023,
0.1378374993801117,
-0.12495739012956619,
0.010472537018358707,
-0.09513464570045471,
-0.12473317980766296,
-0.12340068072080612,
-0.21173705160617828,
0.3321318030357361,
0.16543197631835938,
-0.26834192872047424,
-0.08147048205137253,
-0.2715013325214386,
0.11168414354324341,
0.2878429889678955,
-0.10495882481336594,
0.4120047092437744,
0.3065260350704193,
-0.10151262581348419,
0.09160494804382324,
-0.12331368774175644,
0.11468662321567535,
-0.09150074422359467,
0.09341248124837875,
-0.05850326269865036,
0.05459725484251976,
-0.04872281849384308,
0.029446907341480255,
0.05909844860434532,
0.08715785294771194,
0.09170078486204147,
-0.0699087455868721,
-0.21690280735492706,
-0.09770204871892929,
-0.02429715171456337,
0.14736734330654144,
-0.26726213097572327,
0.20701786875724792,
-0.03272873908281326,
-0.13944368064403534,
-0.013772043399512768,
0.1697319597005844,
-0.00467311218380928,
0.1774158626794815,
-0.3851800858974457,
-0.08450035005807877,
0.03311868757009506,
0.09076204895973206,
-0.06100562959909439,
0.4470572769641876,
0.16537217795848846,
0.11184030026197433,
-0.19659633934497833,
-0.12843088805675507,
0.1302415132522583,
-0.16003312170505524,
-0.012334681116044521,
0.029725808650255203,
-0.014388197101652622,
0.047273945063352585,
-0.09939958900213242,
0.0000886798879946582,
0.1301725059747696,
-0.11505720764398575,
-0.005142143927514553,
-0.01999085582792759,
-0.23358620703220367,
0.17189647257328033,
-0.1948787271976471,
-0.14874929189682007,
0.17826539278030396,
-0.02929767034947872,
0.21057865023612976,
-0.3170105814933777,
0.16388708353042603,
-0.008098564110696316,
0.021131571382284164,
-0.13920125365257263,
-0.26007896661758423,
-0.15082386136054993,
0.08980602771043777,
0.24788548052310944,
0.01932413876056671,
0.08690381050109863,
-0.04815557226538658,
0.2832716107368469,
0.08276809006929398,
-0.06893782317638397,
0.004075909033417702,
-0.06362206488847733,
-0.05046975612640381,
-0.10126464813947678,
0.07039406895637512,
0.12217026203870773,
0.14583717286586761,
0.006257943343371153,
0.02064954861998558,
-0.2571727931499481,
0.01419978216290474,
-0.16109992563724518,
0.1523887664079666,
-0.07478760182857513,
0.031960468739271164,
0.14388063549995422,
0.07011253386735916,
0.008327922783792019,
-0.19764108955860138,
0.06845161318778992,
0.2693803012371063,
0.07597070187330246,
-0.18662495911121368,
-0.2222217470407486,
-0.09431742876768112,
0.020892130210995674,
-0.1520773023366928,
0.08888518065214157,
-0.06024396792054176,
0.20728786289691925,
0.011616094969213009,
-0.0756521224975586,
0.020997924730181694,
0.1255117803812027,
-0.052358098328113556,
-0.2060750126838684,
-0.1119643822312355,
0.5786916613578796,
-0.15340737998485565,
-0.009592803195118904,
-0.07317101955413818,
-0.03433224931359291,
0.009924598038196564,
0.034855786710977554,
0.05100056901574135,
-0.006281874608248472,
-0.18927189707756042,
0.07212943583726883,
-0.14359374344348907,
0.15695109963417053,
-0.18039585649967194,
-0.06510204821825027,
-0.16397835314273834,
-0.06954334676265717,
0.11005157977342606,
0.0024114346597343683,
0.3255278766155243,
-0.1875772625207901,
0.21402576565742493,
-0.020492268726229668,
0.09957104176282883,
-0.17253223061561584,
0.09461610019207001,
0.013781717978417873,
0.05497065186500549,
0.24321496486663818,
-0.0021489583887159824,
-0.01345484983175993,
0.02117345854640007,
0.3115710914134979,
0.018906351178884506,
-0.06819070875644684,
-0.08917427062988281,
-0.24823597073554993,
0.186966672539711,
0.028209852054715157,
0.10932264477014542,
0.011586813256144524,
-0.18820692598819733,
0.01803949661552906,
-0.14006689190864563,
0.025492515414953232,
-0.11181025207042694,
-0.04479646310210228,
0.1368156522512436,
0.1455807089805603,
-0.1424374133348465,
0.0033413085620850325,
-0.11598468571901321,
0.0807698667049408,
-0.23436397314071655,
-0.021118560805916786,
0.011981510557234287,
0.15774394571781158,
0.14969873428344727,
-0.08320088684558868,
-0.42723366618156433,
-0.20842450857162476,
-0.02703731507062912,
0.05006379261612892,
0.08614858984947205,
-0.1772635132074356,
-0.14320899546146393,
-0.02903693914413452,
0.09521463513374329,
-0.2757783830165863,
0.14945551753044128,
0.10705628246068954,
0.22583310306072235
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. development is by medical history and physical examination; periodic imaging is not indicated.Agents/circumstances to avoid: Medications that increase the risk of deep vein thrombosis or are procoagulant; medications that increase growth (e.g., androgenic steroids or growth hormone).Genetic counseling.All individuals with clinically confirmed Proteus syndrome known to these authors have been simplex occurrences caused by somatic mosaicism for the specific de novo pathogenic variant c.49G>A (p.Glu17Lys). It is hypothesized that a non-mosaic (i.e., germline) AKT1 c.49G>A pathogenic variant would be lethal in early development. There is no known risk to offspring of an affected individual; however, the number of affected individuals who have reproduced is very small. Thus, the risks to the parents of an affected child and to affected persons who do reproduce are not increased compared to the general population. Because Proteus syndrome is not inherited, prenatal testing is | [
-0.016989706084132195,
-0.03180919587612152,
-0.11611561477184296,
-0.2805625796318054,
0.2049895077943802,
-0.03711998835206032,
0.001593323308043182,
-0.2696162462234497,
-0.054011084139347076,
-0.009452537633478642,
0.22268308699131012,
-0.00021135929273441434,
-0.1303558647632599,
-0.11263970285654068,
-0.15171518921852112,
0.3150833249092102,
-0.16287975013256073,
0.14311885833740234,
0.09213811159133911,
0.17163878679275513,
0.029116325080394745,
-0.2529957592487335,
0.12315262854099274,
0.09015873074531555,
0.014189747162163258,
-0.2339753955602646,
0.3473001718521118,
-0.0479578897356987,
-0.22312918305397034,
-0.14004302024841309,
0.0088881216943264,
0.06536770612001419,
-0.22139501571655273,
-0.25092992186546326,
-0.1354971081018448,
-0.4519819915294647,
-0.22288094460964203,
0.027324529364705086,
0.23364971578121185,
-0.04095609858632088,
0.03445664048194885,
0.042036864906549454,
0.06582318991422653,
-0.10983630269765854,
0.06840603798627853,
-0.21243447065353394,
0.0584302693605423,
0.07580266892910004,
0.09258511662483215,
0.20870059728622437,
0.053330130875110626,
-0.044793400913476944,
0.09658944606781006,
-0.09756398946046829,
0.21867495775222778,
-0.03279740735888481,
0.03502228483557701,
-0.04746253415942192,
-0.32754987478256226,
-0.19551517069339752,
0.1856347620487213,
-0.01753411442041397,
-0.021834883838891983,
-0.420148640871048,
0.09997209161520004,
-0.03501209244132042,
-0.005803287960588932,
0.1257353574037552,
0.16578805446624756,
0.038594722747802734,
0.22377116978168488,
-0.29337185621261597,
0.08995839208364487,
-0.1306401491165161,
0.1339704692363739,
-0.0023390534333884716,
0.19659912586212158,
-0.06595639884471893,
0.002095431787893176,
-0.11788520961999893,
-0.15129157900810242,
-0.1546006202697754,
-0.1811387538909912,
0.25776925683021545,
-0.2109619826078415,
-0.24533647298812866,
-0.028506524860858917,
-0.09120577573776245,
-0.046714652329683304,
0.15961390733718872,
-0.035112541168928146,
0.1376013457775116,
0.2065035104751587,
0.2229383885860443,
0.2157621532678604,
0.018468422815203667,
-0.0215394739061594,
0.16528213024139404,
-0.13422341644763947,
-0.017200546339154243,
0.056878019124269485,
0.21571581065654755,
-0.27437472343444824,
0.1547451615333557,
0.06971441209316254,
-0.07791240513324738,
-0.016141168773174286,
0.01565130241215229,
0.07519308477640152,
0.0063552106730639935,
-0.07280365377664566,
-0.0799497589468956,
-0.026770485565066338,
-0.11118149012327194,
-0.08603718876838684,
-0.2549852132797241,
-0.06905297935009003,
0.029439466074109077,
-0.21186693012714386,
0.024214209988713264,
0.025816993787884712,
-0.15532562136650085,
-0.10051374137401581,
-0.033582013100385666,
-0.17268867790699005,
-0.04731820523738861,
0.3026695251464844,
-0.18343240022659302,
0.20458218455314636,
-0.08629544079303741,
0.06797122210264206,
-0.0589575469493866,
0.10118941962718964,
-0.14388030767440796,
0.15920977294445038,
-0.17227180302143097,
-0.1398182064294815,
-0.06946071237325668,
0.09168089181184769,
-0.018344884738326073,
0.20657970011234283,
0.11528065800666809,
0.33033472299575806,
0.07681868970394135,
0.027423955500125885,
0.02765059471130371,
0.36098283529281616,
-0.05665081739425659,
0.11494506150484085,
-0.12608996033668518,
0.20207788050174713,
0.010005990974605083,
0.3206455409526825,
0.11495493352413177,
-0.11821911484003067,
-0.09150656312704086,
-0.18774597346782684,
0.16614316403865814,
-0.2625238597393036,
0.041781846433877945,
-0.00264848698861897,
0.006386599503457546,
0.07781200855970383,
-0.20914267003536224,
0.3069680333137512,
0.07563652098178864,
-0.03301837667822838,
-0.1285402625799179,
0.13270486891269684,
-0.047961220145225525,
-0.1815979927778244,
0.148575097322464,
0.04460146650671959,
-0.033704694360494614,
-0.029645178467035294,
-0.021182725206017494,
-0.06621073931455612,
0.04727908968925476,
-0.10698667168617249,
-0.06190861389040947,
0.011969266459345818,
-0.07670202106237411,
-0.11080888658761978,
-0.1141979992389679,
-0.11627905070781708,
-0.18100380897521973,
0.05200670287013054,
0.2541482448577881,
-0.14549081027507782,
0.08183795213699341,
0.07620105147361755,
0.03349166736006737,
-0.16223421692848206,
-0.2795560956001282,
0.06390170753002167,
-0.2591620087623596,
-0.09880366176366806,
0.03254873678088188,
0.11807466298341751,
-0.22702816128730774,
-0.022313620895147324,
0.16150544583797455,
-0.02248407155275345,
-0.10138407349586487,
0.16449569165706635,
0.07957735657691956,
-0.012889420613646507,
-0.13283929228782654,
-0.10749118030071259,
0.11930537223815918,
0.1360505074262619,
0.2717495262622833,
-0.10577784478664398,
-0.05291977897286415,
-0.05551675334572792,
0.03090430423617363,
-0.0440240353345871,
-0.2771886885166168,
0.10204269737005234,
0.19436626136302948,
-0.1524871438741684,
0.177766352891922,
-0.08756472170352936,
-0.21776530146598816,
-0.1162773072719574,
0.14151312410831451,
-0.0035310012754052877,
-0.04399450495839119,
0.09006118774414062,
0.16739702224731445,
-0.026603419333696365,
-0.03594329580664635,
0.06433418393135071,
-0.013406950980424881,
-0.11309151351451874,
-0.18168160319328308,
0.03344253823161125,
0.15229487419128418,
-0.02488263137638569,
0.06613047420978546,
-0.059156909584999084,
0.021754808723926544,
0.164524644613266,
-0.07700736820697784,
-0.054792940616607666,
0.09864622354507446,
-0.00496165594086051,
-0.03583760932087898,
-0.28869765996932983,
-0.011791438795626163,
-0.014663967303931713,
-0.2510906457901001,
0.17064015567302704,
0.020341617986559868,
-0.22011922299861908,
-0.16210588812828064,
0.031547825783491135,
0.06768083572387695,
0.2132863998413086,
0.04308053478598595,
0.263480007648468,
0.1520226001739502,
0.08472491800785065,
0.07921575009822845,
-0.3317350745201111,
-0.004991477821022272,
-0.1366095095872879,
0.046253547072410583,
-0.12200626730918884,
-0.11629147827625275,
-0.010161934420466423,
0.06457758694887161,
-0.09410862624645233,
0.0021595745347440243,
-0.19546562433242798,
0.09901098161935806,
0.15648691356182098,
0.18601654469966888,
0.014627664349973202,
0.1506449282169342,
-0.024078022688627243,
-0.010588379576802254,
-0.026026790961623192,
0.22878317534923553,
0.21352607011795044,
0.12016936391592026,
-0.17325657606124878,
0.06576969474554062,
0.025434888899326324,
0.015111375600099564,
-0.05821690335869789,
0.20740623772144318,
0.10950644314289093,
-0.03403998911380768,
0.03235051408410072,
0.17359255254268646,
-0.17717228829860687,
-0.07631586492061615,
0.04847215116024017,
-0.11877597123384476,
0.25006577372550964,
0.18799549341201782,
-0.008478038012981415,
-0.09947532415390015,
0.037314049899578094,
0.11226993799209595,
0.24928945302963257,
0.0027872349601238966,
0.08577572554349899,
-0.18392348289489746,
-0.11638985574245453,
0.12959273159503937,
-0.11900293827056885,
0.12715043127536774,
-0.20111525058746338,
0.0984167605638504,
0.048089951276779175,
-0.09488397091627121,
0.17245793342590332,
0.11603084951639175,
-0.07051468640565872,
0.11916274577379227,
0.26496970653533936,
0.046274639666080475,
0.125879168510437,
-0.05889149755239487,
-0.08104982227087021,
0.21353332698345184,
-0.056360874325037,
0.15032030642032623,
0.27909037470817566,
-0.0356263592839241,
-0.06568801403045654,
0.02917628362774849,
0.17563743889331818,
0.09539464116096497,
-0.06280636042356491,
-0.02458486519753933,
-0.14276140928268433,
-0.13629360496997833,
0.019343437626957893,
-0.06810998171567917,
0.015605280175805092,
0.13614462316036224,
0.0005789009155705571,
0.2635272741317749,
-0.07791633903980255,
0.1632107049226761,
-0.24259409308433533,
-0.08985187858343124,
-0.09965557605028152,
-0.2093062698841095,
0.10710451751947403,
-0.22820493578910828,
0.2742536664009094,
-0.10748481750488281,
0.15490727126598358,
0.11769488453865051,
-0.009410020895302296,
0.09023241698741913,
-0.08474323153495789,
-0.01659141667187214,
-0.051401808857917786,
-0.1139010488986969,
-0.008338578045368195,
-0.09738374501466751,
-0.0575447641313076,
0.06387347728013992,
0.1657109260559082,
0.06744746118783951,
0.3888876438140869,
0.10991731286048889,
0.075568787753582,
-0.10616189241409302,
0.05042387917637825,
0.16308923065662384,
-0.15057861804962158,
0.12016105651855469,
-0.03564484044909477,
-0.21339400112628937,
0.1369774043560028,
0.08026573061943054,
0.16745427250862122,
-0.2136421948671341,
-0.009340314194560051,
-0.06249020993709564,
-0.23174722492694855,
0.06329771876335144,
-0.04081603139638901,
-0.17832611501216888,
0.013604122214019299,
-0.053946830332279205,
-0.03652547672390938,
0.06273331493139267,
-0.16881726682186127,
-0.08207564800977707,
0.1919693797826767,
-0.324968159198761,
-0.2374054491519928,
-0.15542645752429962,
-0.13572463393211365,
-0.17251718044281006,
0.0033737223129719496,
0.15908609330654144,
0.058953024446964264,
0.10376095026731491,
-0.010063677094876766,
0.10306080430746078,
-0.08010707050561905,
0.5269882678985596,
-0.03262777253985405,
-0.10007288306951523,
-0.07879248261451721,
-0.15123343467712402,
-0.0715489611029625,
-0.10474146902561188,
0.15506552159786224,
0.08677011728286743,
0.01925760507583618,
-0.1956573724746704,
0.15034978091716766,
0.2914951741695404,
-0.052137769758701324,
-0.13385751843452454,
-0.12730157375335693,
0.023523598909378052,
-0.1295432150363922,
0.04384606331586838,
0.004188070073723793,
0.2769252359867096,
0.1814502626657486,
0.053968645632267,
-0.20370455086231232,
-0.14874091744422913,
-0.023441219702363014,
0.14063720405101776,
0.14954128861427307,
0.03274424001574516,
0.06207205355167389,
-0.0894894152879715,
0.210847407579422,
0.2089439481496811,
0.07968341559171677,
0.06271295249462128,
-0.15093007683753967,
-0.03224405273795128,
-0.018714839592576027,
0.09196788817644119,
-0.011749425902962685,
0.11198516190052032,
0.00036057253601029515,
0.06261670589447021,
0.006399710662662983,
-0.16231976449489594,
0.08670161664485931,
0.19973957538604736,
-0.02707410603761673,
-0.006716624833643436,
-0.07876694202423096,
0.1407046914100647,
-0.2458166629076004,
0.017819631844758987,
0.285492479801178,
0.0012927775969728827,
-0.006954753305763006,
0.025932030752301216,
-0.09779191017150879,
-0.01523725874722004,
0.13689762353897095,
-0.02291112206876278,
-0.0021411373745650053,
0.009115532971918583,
0.14335867762565613,
-0.10236749798059464,
0.018705002963542938,
-0.05228429287672043,
-0.06818918138742447,
0.142142653465271,
-0.25522124767303467,
-0.0141901271417737,
0.25779563188552856,
-0.00473436713218689,
0.15153051912784576,
-0.06609409302473068,
0.08942517638206482,
0.19639700651168823,
0.033519357442855835,
-0.23456227779388428,
0.25537440180778503,
-0.010380493476986885,
0.14113211631774902,
0.014758780598640442,
0.26649752259254456,
0.3713715374469757,
-0.21021342277526855,
-0.20173399150371552,
0.21610118448734283,
-0.08991186320781708,
-0.07860341668128967,
-0.06978969275951385,
0.04297071695327759,
0.16077792644500732,
0.18881288170814514,
0.10866710543632507,
-0.18347856402397156,
-0.054404158145189285,
-0.10679931938648224,
-0.34699952602386475,
-0.10937712341547012,
0.14406460523605347,
-0.15037696063518524,
-0.10862264037132263,
0.17644692957401276,
-0.10275445133447647,
0.07760600000619888,
-0.06806491315364838,
-0.1635620892047882,
-0.13038714230060577,
-0.03916701674461365,
-0.024766886606812477,
-0.044117558747529984,
-0.19262948632240295,
0.16849762201309204,
0.05944986641407013,
-0.048167455941438675,
-0.18489257991313934,
-0.13510124385356903,
0.09697967022657394,
-0.272372841835022,
0.12528856098651886,
-0.21201716363430023,
-0.0647771954536438,
-0.061867352575063705,
0.1352664977312088,
0.04681820049881935,
0.01609393022954464,
0.06389908492565155,
0.07209048420190811,
-0.22582197189331055,
0.07881596684455872,
-0.19548682868480682,
-0.1127476692199707,
0.1057061031460762,
0.12907648086547852,
-0.0055481852032244205,
0.04490397125482559,
0.25445103645324707,
0.041064485907554626,
0.3379492163658142,
0.31755563616752625,
-0.02375362627208233,
-0.22312688827514648,
-0.006714258808642626,
-0.13268280029296875,
-0.2331075817346573,
0.09383693337440491,
0.005200153682380915,
0.034002404659986496,
-0.00503957737237215,
0.31765976548194885,
0.03448505327105522,
-0.1278398036956787,
0.013339745812118053,
-0.023173820227384567,
0.15559303760528564,
0.21946710348129272,
0.22014322876930237,
-0.02062096633017063,
0.04237817972898483,
-0.1369195431470871,
-0.11890441924333572,
-0.10334300249814987,
0.24499940872192383,
-0.12113183736801147,
-0.0026945832651108503,
0.01607118919491768,
-0.22303041815757751,
-0.06466367095708847,
-0.1850765198469162,
0.23153021931648254,
0.1233130693435669,
-0.2625957727432251,
-0.0497141033411026,
-0.15706178545951843,
-0.04992270469665527,
0.2694813907146454,
-0.13069330155849457,
0.13090984523296356,
0.3841109871864319,
0.0037679667584598064,
-0.06754395365715027,
-0.1563025563955307,
0.19216476380825043,
0.03168320283293724,
-0.039886243641376495,
0.0806889459490776,
0.24984470009803772,
0.05962057039141655,
-0.017538057640194893,
-0.03322352096438408,
-0.020472688600420952,
0.11494914442300797,
-0.12251418083906174,
-0.18462678790092468,
-0.04533936828374863,
-0.004702552687376738,
0.06830089539289474,
-0.24456089735031128,
0.2857110798358917,
-0.01393137127161026,
-0.1571824997663498,
-0.11396227777004242,
0.00961429812014103,
-0.026305273175239563,
0.31239888072013855,
-0.21545235812664032,
0.06763360649347305,
0.04739212617278099,
0.3132512867450714,
0.03977184742689133,
0.3697311580181122,
0.12044068425893784,
0.17587807774543762,
-0.2817653715610504,
-0.10364289581775665,
0.356551855802536,
-0.2539542317390442,
-0.12552477419376373,
0.04090031608939171,
-0.06772997230291367,
-0.21112819015979767,
-0.14118428528308868,
-0.07262422889471054,
0.2613941729068756,
0.005978775676339865,
0.09223971515893936,
-0.012654497288167477,
-0.32832732796669006,
0.04696687310934067,
-0.19008108973503113,
-0.04277900606393814,
0.06097453832626343,
-0.00890848133713007,
0.17405158281326294,
-0.3558879494667053,
0.22760318219661713,
0.01469386275857687,
0.02227797731757164,
-0.10886894911527634,
-0.04654928296804428,
-0.002672466216608882,
0.18449781835079193,
-0.02098582312464714,
0.1676017791032791,
0.16175194084644318,
-0.1097591295838356,
0.1049162819981575,
0.008374597877264023,
0.08188281208276749,
-0.07025816291570663,
-0.10125730186700821,
-0.07820411771535873,
0.0010363347828388214,
-0.04873451218008995,
0.10861028730869293,
-0.07144172489643097,
0.02692672237753868,
0.053890619426965714,
-0.28521835803985596,
-0.14688996970653534,
-0.34618714451789856,
0.07675426453351974,
0.07909923046827316,
-0.029597481712698936,
0.12851986289024353,
0.00991806946694851,
-0.09729551523923874,
-0.13714542984962463,
0.033212948590517044,
0.43468916416168213,
-0.11939398944377899,
-0.33063358068466187,
-0.10538938641548157,
-0.07520978152751923,
0.14451859891414642,
-0.07934680581092834,
-0.11424948275089264,
0.10595952719449997,
0.16251376271247864,
-0.1368395984172821,
-0.21240483224391937,
-0.14554791152477264,
-0.10418777167797089,
0.0027462977450340986,
-0.13964512944221497,
-0.02816784754395485,
0.5178003311157227,
-0.004273947328329086,
-0.08594533056020737,
-0.06870454549789429,
0.06487129628658295,
0.03067358024418354,
0.04295358061790466,
0.11069583147764206,
0.05090077593922615,
-0.24151526391506195,
0.12297093868255615,
-0.21122503280639648,
-0.02390526793897152,
-0.16370217502117157,
-0.1451331079006195,
-0.3227468729019165,
0.12711089849472046,
0.05206761881709099,
-0.18250258266925812,
0.09965066611766815,
-0.1565500944852829,
0.215249702334404,
-0.023797178640961647,
0.007824169471859932,
-0.04432143270969391,
-0.030286449939012527,
0.07099293917417526,
-0.25353044271469116,
0.12026087939739227,
0.014574219472706318,
-0.018425675109028816,
0.07093054056167603,
0.12171122431755066,
0.16806860268115997,
0.009824168868362904,
-0.024536458775401115,
-0.31898611783981323,
0.1908896416425705,
0.14317695796489716,
0.0955372080206871,
0.18906724452972412,
-0.04341605678200722,
0.07981906831264496,
-0.144621342420578,
0.23205208778381348,
-0.034780777990818024,
-0.18180051445960999,
-0.08559954911470413,
0.05757550895214081,
0.033661726862192154,
0.031223822385072708,
-0.19384805858135223,
-0.07183615118265152,
-0.16585031151771545,
0.15430620312690735,
0.21355192363262177,
0.06120910122990608,
-0.07845393568277359,
0.09518618881702423,
-0.3440069854259491,
-0.11932829767465591,
0.037761468440294266,
-0.0777498185634613,
0.04459027200937271,
-0.12940216064453125,
-0.02073829062283039,
-0.0031626399140805006,
0.12030476331710815,
-0.1542476862668991,
0.1390703320503235,
-0.023847294971346855,
0.11763275414705276
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. ). It is hypothesized that a non-mosaic (i.e., germline) AKT1 c.49G>A pathogenic variant would be lethal in early development. There is no known risk to offspring of an affected individual; however, the number of affected individuals who have reproduced is very small. Thus, the risks to the parents of an affected child and to affected persons who do reproduce are not increased compared to the general population. Because Proteus syndrome is not inherited, prenatal testing is not indicated.DiagnosisSuggestive FindingsProteus syndrome (PS) should be suspected in a proband with the following.Major findingsDistorting, progressive overgrowth, typically of postnatal onset often resulting in asymmetric distortion of the skeletal architecture. Hemimegencephaly can be prenatal.Cerebriform connective tissue nevi (CCTN), a specific type of connective tissue nevus that is characterized by deep grooves and gyrations as seen on the surface of the brainLinear verruc | [
0.03678436577320099,
-0.09905698150396347,
-0.06952840834856033,
-0.34840378165245056,
0.18199488520622253,
-0.07221391052007675,
-0.08287258446216583,
-0.2563115060329437,
-0.11480829119682312,
0.13899508118629456,
0.293163001537323,
0.09829501062631607,
0.028766466304659843,
-0.10705217719078064,
-0.11141496151685715,
0.1284020096063614,
-0.019181327894330025,
-0.14654667675495148,
-0.09352303296327591,
0.03370372951030731,
0.004931848030537367,
-0.03482728451490402,
-0.07646624743938446,
0.0723453089594841,
-0.026967909187078476,
-0.18683263659477234,
0.21195487678050995,
0.18363314867019653,
-0.0220185536891222,
0.02358791045844555,
0.059937018901109695,
-0.05414910614490509,
-0.08032483607530594,
-0.30389657616615295,
0.08329593390226364,
-0.25098034739494324,
-0.32230138778686523,
-0.07082539796829224,
0.13912785053253174,
-0.13844124972820282,
0.0222790390253067,
0.06282998621463776,
-0.18575453758239746,
-0.2129545360803604,
0.3682347238063812,
-0.10071951150894165,
-0.0485028438270092,
0.2233424186706543,
0.12639132142066956,
0.1421983689069748,
0.35051366686820984,
-0.09776052087545395,
0.21758820116519928,
-0.044228073209524155,
0.16456106305122375,
-0.16153723001480103,
0.003936301916837692,
-0.24531877040863037,
-0.5060260891914368,
0.06181904673576355,
0.17770355939865112,
-0.04513993114233017,
0.18161344528198242,
-0.47427672147750854,
0.04154055565595627,
-0.14990182220935822,
-0.01968914456665516,
0.09033054113388062,
0.1955963522195816,
-0.1011120080947876,
0.37992745637893677,
-0.08171935379505157,
-0.2276497185230255,
-0.13312886655330658,
-0.13823531568050385,
-0.2195308655500412,
0.09128916263580322,
-0.15034805238246918,
-0.09254848957061768,
-0.26957207918167114,
-0.02297843061387539,
-0.14046165347099304,
-0.1298496574163437,
0.0768943727016449,
-0.243772953748703,
-0.09884289652109146,
0.05085716024041176,
0.13839775323867798,
-0.013900686986744404,
0.1483335942029953,
0.06644070893526077,
0.000976146082393825,
-0.02762981876730919,
0.13368043303489685,
0.1581221967935562,
-0.07163560390472412,
0.15852361917495728,
-0.05839480087161064,
-0.16237008571624756,
-0.009330605156719685,
0.04333298280835152,
0.2850237488746643,
-0.014613364823162556,
-0.07012588530778885,
0.12612886726856232,
-0.1800941824913025,
-0.12968678772449493,
0.037898950278759,
0.17305196821689606,
-0.047884222120046616,
-0.12877270579338074,
-0.14036761224269867,
0.02393457479774952,
-0.14048300683498383,
-0.2878608703613281,
-0.23339378833770752,
0.12658990919589996,
-0.12023158371448517,
-0.14560489356517792,
-0.1331981122493744,
0.07452858239412308,
-0.11984017491340637,
0.10234249383211136,
0.03129128739237785,
0.06502368301153183,
0.03092382661998272,
0.2066156268119812,
-0.26054248213768005,
-0.10051193088293076,
-0.08878173679113388,
0.008394727483391762,
-0.0374271459877491,
-0.08329722285270691,
-0.2944576144218445,
0.13423465192317963,
0.25819340348243713,
-0.13282375037670135,
-0.03725621476769447,
0.0999823808670044,
0.08061523735523224,
0.20949819684028625,
0.20793463289737701,
0.3489799499511719,
0.007373003754764795,
0.14510512351989746,
0.046628206968307495,
0.18438127636909485,
0.08355017751455307,
0.12730878591537476,
-0.011795767582952976,
0.33921539783477783,
0.025335483253002167,
0.2726282477378845,
0.034281957894563675,
0.04959931969642639,
-0.15547285974025726,
-0.07956469804048538,
0.020767411217093468,
0.001484410953707993,
0.13942213356494904,
-0.0007825148059055209,
-0.009046518243849277,
-0.016606565564870834,
-0.15069106221199036,
-0.07108501344919205,
0.11543537676334381,
-0.07298100739717484,
-0.07798155397176743,
0.15484923124313354,
-0.08329953998327255,
-0.30502721667289734,
0.10945761948823929,
-0.11309849470853806,
0.1146819069981575,
-0.031093312427401543,
0.06281982362270355,
0.11122453212738037,
0.2495851367712021,
0.016812078654766083,
0.2237798124551773,
0.09812357276678085,
0.04376554861664772,
0.042340949177742004,
-0.2933334708213806,
0.011462951079010963,
-0.16263315081596375,
0.020423369482159615,
0.252474308013916,
-0.2755814492702484,
-0.14002080261707306,
0.08089149743318558,
-0.18737384676933289,
-0.1722768247127533,
-0.09063102304935455,
-0.07758062332868576,
-0.2536080777645111,
-0.1224193125963211,
-0.11216332018375397,
0.12883822619915009,
0.024810612201690674,
0.11256676912307739,
-0.06243514269590378,
0.1520581692457199,
-0.04910251125693321,
0.2611146569252014,
0.20110292732715607,
0.01540222018957138,
-0.2928275465965271,
0.05673011764883995,
0.14173094928264618,
-0.09446815401315689,
0.3966333866119385,
-0.1203305572271347,
0.016681725159287453,
0.04663429409265518,
0.01926005259156227,
-0.1409093141555786,
-0.1785215586423874,
-0.05646920204162598,
0.2799011766910553,
-0.18491411209106445,
0.2565792202949524,
-0.1361750364303589,
-0.24930739402770996,
-0.3896801471710205,
0.09468064457178116,
0.01188870333135128,
-0.03127708286046982,
0.08026008307933807,
-0.019903957843780518,
-0.12867480516433716,
-0.020602431148290634,
0.01659434288740158,
0.16458305716514587,
0.11087856441736221,
-0.18138374388217926,
-0.16533367335796356,
0.19195090234279633,
0.011856582015752792,
0.028329750522971153,
-0.2075721174478531,
0.025416919961571693,
0.0448281392455101,
-0.11864344030618668,
-0.17793023586273193,
0.10148191452026367,
0.03655225783586502,
0.10820508748292923,
-0.10737267881631851,
0.040566105395555496,
0.04147906228899956,
-0.22551675140857697,
0.17684738337993622,
0.08130980283021927,
-0.1316463053226471,
-0.17572717368602753,
0.13448502123355865,
0.030723514035344124,
0.1509731411933899,
0.023251716047525406,
0.2806267738342285,
0.20038871467113495,
0.2537895441055298,
0.08979212492704391,
-0.25784626603126526,
-0.1971176564693451,
-0.07717026025056839,
0.2474837601184845,
-0.08758033066987991,
-0.269343763589859,
-0.20599590241909027,
0.19817157089710236,
0.04450837895274162,
0.11697357147932053,
-0.10721296817064285,
0.005572514608502388,
0.21937480568885803,
-0.02896987646818161,
0.06909053772687912,
0.173411563038826,
0.03809589147567749,
-0.07800077646970749,
-0.07525258511304855,
0.0021039440762251616,
0.41795051097869873,
0.04452156275510788,
-0.3919283449649811,
0.2303621470928192,
0.06704764068126678,
-0.10543176531791687,
0.020113179460167885,
0.1635105311870575,
0.07378901541233063,
-0.04997237026691437,
0.03911048546433449,
0.1861729770898819,
0.01851707324385643,
-0.052116408944129944,
0.2407393604516983,
-0.15213407576084137,
0.11022023856639862,
0.15202045440673828,
-0.11564952880144119,
0.030471332371234894,
0.04008394479751587,
-0.1893121749162674,
0.3178189992904663,
-0.1219722330570221,
0.025743424892425537,
-0.1026417464017868,
-0.15416942536830902,
0.15464141964912415,
0.06960621476173401,
0.14707009494304657,
-0.04120451211929321,
0.007688817102462053,
-0.1826809197664261,
0.10774459689855576,
0.2781178653240204,
0.14332228899002075,
0.08517792075872421,
-0.1024567037820816,
0.09427357465028763,
0.04140324145555496,
0.12324060499668121,
0.14549508690834045,
-0.11615762859582901,
0.20703403651714325,
-0.12488695234060287,
0.08890113979578018,
-0.014094345271587372,
0.09309706091880798,
-0.13501590490341187,
-0.1931382268667221,
0.26301509141921997,
-0.010047877207398415,
-0.037667229771614075,
-0.21427784860134125,
0.07042527198791504,
-0.030444102361798286,
-0.1558476835489273,
-0.21026471257209778,
-0.01423169206827879,
-0.14235743880271912,
0.04736847057938576,
0.10613378137350082,
-0.003149950411170721,
0.05323798954486847,
-0.036380160599946976,
-0.07022671401500702,
0.02034231275320053,
-0.10907238721847534,
-0.026073362678289413,
-0.33051595091819763,
0.08160427957773209,
-0.06008452549576759,
0.12403404712677002,
0.06856314837932587,
0.0057884701527655125,
0.08457580208778381,
-0.16074977815151215,
-0.1186981052160263,
-0.2222951501607895,
0.014241904951632023,
-0.1398991346359253,
-0.1734512448310852,
-0.25200197100639343,
0.05842365697026253,
0.1257718950510025,
-0.048676811158657074,
0.23582778871059418,
-0.0036773281171917915,
0.0992470309138298,
-0.04918133467435837,
-0.03211445361375809,
0.04519135504961014,
-0.1743163764476776,
0.057936377823352814,
-0.237667515873909,
-0.2319134920835495,
-0.0882701650261879,
0.16283631324768066,
0.23755408823490143,
-0.14890705049037933,
-0.15654054284095764,
0.06131664663553238,
-0.3448861241340637,
0.06448646634817123,
-0.08204831182956696,
-0.2767479419708252,
0.15352146327495575,
-0.04408736899495125,
-0.0395018495619297,
0.2762855589389801,
0.0013843589695170522,
0.020420348271727562,
0.029826706275343895,
-0.10046552121639252,
-0.2358357012271881,
-0.04785148426890373,
0.051447559148073196,
-0.002493717707693577,
0.05297284573316574,
0.16971895098686218,
0.08311115205287933,
-0.013163994066417217,
-0.17268891632556915,
0.19797274470329285,
-0.19233635067939758,
0.38802996277809143,
-0.14412321150302887,
-0.10480978339910507,
-0.15851683914661407,
-0.1775498390197754,
-0.03389940410852432,
-0.12984654307365417,
0.0768517479300499,
-0.027657506987452507,
-0.009255790151655674,
-0.11289855092763901,
0.16763415932655334,
-0.21734619140625,
0.10351262986660004,
-0.1293002814054489,
-0.04287965968251228,
-0.032015733420848846,
-0.07371354103088379,
0.13643108308315277,
-0.13420361280441284,
0.2383035123348236,
0.2255576103925705,
-0.2268218696117401,
-0.11806373298168182,
0.20172688364982605,
-0.04583750665187836,
0.19589728116989136,
0.04245186597108841,
0.027365854009985924,
0.02465149015188217,
-0.07357463985681534,
0.27621084451675415,
0.07387880980968475,
0.07035217434167862,
0.010823018848896027,
-0.06466344743967056,
0.0844433605670929,
0.05789382383227348,
0.05459260195493698,
-0.05260717496275902,
0.06454107910394669,
0.007691019680351019,
0.1198502704501152,
0.16660085320472717,
-0.03783635050058365,
0.14218415319919586,
0.15785478055477142,
-0.0787881538271904,
-0.004226839169859886,
-0.19008977711200714,
0.028643663972616196,
0.013231231831014156,
0.09813980013132095,
0.30241742730140686,
-0.1930730938911438,
-0.08111876249313354,
0.16266818344593048,
-0.29954078793525696,
0.10451161116361618,
0.022506821900606155,
-0.010920023545622826,
0.0027187264058738947,
0.0929422602057457,
0.12117677181959152,
-0.07257454097270966,
-0.0784107968211174,
-0.06428961455821991,
0.0401993989944458,
0.06270912289619446,
-0.09255576133728027,
-0.03361217677593231,
0.19210365414619446,
0.07611457258462906,
0.2633151113986969,
-0.07616069912910461,
0.13774718344211578,
0.12008977681398392,
-0.012782083824276924,
-0.10191046446561813,
0.11664633452892303,
-0.23465657234191895,
0.20255161821842194,
-0.07132470607757568,
0.08388561755418777,
0.32599133253097534,
0.041937991976737976,
-0.03348309174180031,
0.0480584017932415,
0.05751492828130722,
-0.106410451233387,
-0.13352632522583008,
-0.00043489865493029356,
0.16453473269939423,
0.16749101877212524,
0.03337349742650986,
-0.06262825429439545,
-0.027095286175608635,
-0.026353731751441956,
-0.33206766843795776,
-0.1776576042175293,
0.03915700316429138,
-0.06622257828712463,
0.0041641551069915295,
-0.024531694129109383,
-0.1949474960565567,
0.11898575723171234,
-0.10529833287000656,
0.029696663841605186,
-0.029316609725356102,
0.1215144619345665,
-0.049086153507232666,
-0.03919711336493492,
-0.02461186796426773,
-0.004115186631679535,
0.016310416162014008,
-0.03984573855996132,
-0.05228270962834358,
0.0006363802240230143,
0.07574386894702911,
-0.06860093027353287,
-0.04485420882701874,
-0.07472671568393707,
-0.07837694138288498,
0.07811329513788223,
0.033836111426353455,
0.14371688663959503,
-0.16641975939273834,
0.02232459932565689,
-0.24790067970752716,
-0.016080470755696297,
0.1401774287223816,
-0.24893954396247864,
0.23185808956623077,
0.16258136928081512,
0.006858367472887039,
0.0025725632440298796,
-0.011246618814766407,
0.11633095890283585,
0.11553800106048584,
0.0425032377243042,
0.191853865981102,
-0.006605984177440405,
-0.08634979277849197,
0.015790827572345734,
-0.08997249603271484,
-0.10028154402971268,
-0.03677995502948761,
0.06459666788578033,
0.03875910863280296,
-0.11975400894880295,
0.34706151485443115,
-0.0903627797961235,
0.12384019792079926,
0.010279708541929722,
0.014812600798904896,
0.1111142560839653,
0.16647593677043915,
0.2405422180891037,
0.057236313819885254,
-0.033285290002822876,
0.062372442334890366,
0.04382313787937164,
-0.01293149869889021,
0.15033495426177979,
-0.23044663667678833,
-0.03863759711384773,
0.05953453108668327,
-0.14296163618564606,
-0.1431031972169876,
-0.3323118984699249,
0.027132811024785042,
0.3115113377571106,
-0.26311102509498596,
-0.029851898550987244,
-0.2535575330257416,
0.038684211671352386,
0.3916536569595337,
-0.11168872565031052,
0.13495521247386932,
0.3739031255245209,
0.08665992319583893,
-0.06031765416264534,
-0.19607892632484436,
0.12862439453601837,
0.08499819785356522,
0.05095643922686577,
-0.04973870888352394,
0.17001204192638397,
-0.08584319800138474,
0.21097567677497864,
-0.004483780357986689,
0.1424940526485443,
0.08604740351438522,
-0.07837788015604019,
-0.0671471357345581,
0.06119021400809288,
-0.07542428374290466,
0.13259416818618774,
-0.208124041557312,
0.13001461327075958,
-0.022351577877998352,
-0.20270101726055145,
-0.17805293202400208,
0.051360633224248886,
0.010660693980753422,
0.2785660922527313,
-0.1640007197856903,
0.21301880478858948,
-0.011954368092119694,
0.3279239237308502,
0.04324190318584442,
0.29616522789001465,
-0.13918298482894897,
0.12837666273117065,
-0.22131097316741943,
-0.06625180691480637,
0.05988924950361252,
0.047491829842329025,
-0.11927732080221176,
0.06640340387821198,
0.05612381175160408,
0.02814125269651413,
-0.05245864391326904,
-0.12748929858207703,
0.05119788646697998,
0.08846452087163925,
0.10211464017629623,
0.03980061411857605,
-0.11640292406082153,
-0.09884405881166458,
-0.17028644680976868,
0.06273310631513596,
0.17502956092357635,
0.024987487122416496,
0.25016799569129944,
-0.11025675386190414,
0.18002185225486755,
-0.059233564883470535,
-0.07600061595439911,
-0.33399248123168945,
-0.2455611675977707,
-0.13775427639484406,
0.05769471824169159,
-0.08966593444347382,
0.1316078007221222,
0.16399353742599487,
-0.00561121292412281,
0.11248549818992615,
-0.008114977739751339,
0.04846145585179329,
0.035991981625556946,
-0.10304921865463257,
0.11828648298978806,
-0.06833062320947647,
-0.007538264617323875,
0.11561897397041321,
0.17240318655967712,
-0.07895871251821518,
0.18036384880542755,
-0.3500809669494629,
-0.1462848037481308,
-0.3471756875514984,
0.1327400803565979,
0.01642526313662529,
0.003795125288888812,
-0.047948695719242096,
-0.06228961423039436,
0.27865904569625854,
-0.1740347146987915,
0.17504636943340302,
0.41502514481544495,
-0.00824109185487032,
-0.1988253891468048,
-0.19216060638427734,
-0.16262802481651306,
0.06156539171934128,
0.049250341951847076,
-0.2264769971370697,
0.0328228585422039,
0.10688462853431702,
-0.08380723744630814,
0.009586293250322342,
-0.09138592332601547,
0.00029917972278781235,
-0.06887449324131012,
-0.10503116250038147,
-0.20582646131515503,
0.3976292312145233,
0.04575614258646965,
-0.1338573843240738,
-0.03719201311469078,
-0.125662162899971,
0.13442784547805786,
-0.05243230611085892,
0.12140300124883652,
0.15756303071975708,
-0.1777237206697464,
0.23466993868350983,
-0.18266339600086212,
-0.008199568837881088,
-0.2095900923013687,
-0.014307337813079357,
-0.054619308561086655,
0.00871066004037857,
0.23426103591918945,
0.060360465198755264,
0.24264076352119446,
-0.23156973719596863,
-0.08839511126279831,
-0.07646419107913971,
-0.08210264146327972,
-0.06893601268529892,
0.01619294099509716,
0.06838443875312805,
-0.14963862299919128,
0.17303824424743652,
-0.028705647215247154,
0.12863421440124512,
-0.13000410795211792,
0.1705700308084488,
0.15710724890232086,
0.01236242987215519,
-0.04365488514304161,
-0.24408578872680664,
0.04989341273903847,
-0.07527864724397659,
0.02341528981924057,
0.18530860543251038,
-0.016123497858643532,
-0.2737308740615845,
-0.2447708398103714,
0.012642467394471169,
0.09778230637311935,
-0.00531409028917551,
-0.015150865539908409,
0.07810980826616287,
-0.17197491228580475,
0.06069197878241539,
0.04744172841310501,
-0.03062848374247551,
-0.15408045053482056,
0.09314415603876114,
0.10217558592557907,
0.17649751901626587,
0.16167448461055756,
-0.25075531005859375,
-0.08840443938970566,
-0.20981751382350922,
-0.01815437525510788,
-0.02078540250658989,
0.05383123829960823,
-0.07108940184116364,
-0.19664275646209717,
0.01642139069736004,
0.026849845424294472,
-0.09783659875392914,
0.25127294659614563,
0.0601421482861042,
-0.1052880585193634
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. inherited, prenatal testing is not indicated.DiagnosisSuggestive FindingsProteus syndrome (PS) should be suspected in a proband with the following.Major findingsDistorting, progressive overgrowth, typically of postnatal onset often resulting in asymmetric distortion of the skeletal architecture. Hemimegencephaly can be prenatal.Cerebriform connective tissue nevi (CCTN), a specific type of connective tissue nevus that is characterized by deep grooves and gyrations as seen on the surface of the brainLinear verrucous epidermal nevus (LVEN), a streaky, pigmented, rough nevus that often follows the lines of Blaschko and can be present anywhere on the bodyAdipose dysregulation including lipomatous overgrowth and lipoatrophyOther:Vascular malformations including cutaneous capillary malformations, prominent venous patterning or varicosities, and lymphatic malformationsOvergrowth of other tissues, most commonly spleen, liver, thymus, and gastrointestinal tractTumors, most commonly meningiomas | [
-0.0525774322450161,
-0.03762168437242508,
-0.028996974229812622,
-0.13740159571170807,
0.19166305661201477,
-0.08216775953769684,
-0.08456344902515411,
-0.18420150876045227,
-0.10716035217046738,
0.03327307850122452,
0.2231874018907547,
0.0010750355431810021,
0.08288563042879105,
0.018511081114411354,
-0.08331698924303055,
-0.01751675084233284,
-0.05141611024737358,
-0.14144690334796906,
-0.11817389726638794,
-0.027495361864566803,
0.10148053616285324,
-0.16679708659648895,
-0.0045459819957613945,
0.15191560983657837,
-0.13654689490795135,
-0.09662332385778427,
0.19915340840816498,
0.3312256932258606,
0.09103553742170334,
0.08631587028503418,
-0.013776464387774467,
-0.01896286942064762,
0.043580178171396255,
-0.25894051790237427,
0.21753822267055511,
-0.15247799456119537,
-0.2425396889448166,
-0.09326718747615814,
-0.04643351584672928,
-0.16390123963356018,
0.05773453414440155,
0.12906645238399506,
-0.23372408747673035,
-0.1695612519979477,
0.22285032272338867,
-0.01592646725475788,
-0.11709682643413544,
0.2320616990327835,
0.06929587572813034,
0.19630667567253113,
0.241715669631958,
-0.1213131994009018,
0.17338310182094574,
-0.0405169352889061,
0.18202431499958038,
-0.26829028129577637,
0.012501376681029797,
-0.19657595455646515,
-0.3964093327522278,
0.20147454738616943,
0.1673804670572281,
-0.021913474425673485,
0.20857538282871246,
-0.371680349111557,
0.08142216503620148,
-0.08735183626413345,
-0.12424954026937485,
0.08102717995643616,
0.1482895463705063,
0.07006306946277618,
0.44940823316574097,
-0.11756986379623413,
-0.19904537498950958,
-0.08374341577291489,
-0.19364865124225616,
-0.2107250988483429,
-0.008183642290532589,
-0.17609162628650665,
-0.02116147242486477,
-0.22377334535121918,
-0.0005956012173555791,
-0.0456811860203743,
-0.00169272325001657,
0.10502680391073227,
-0.22114261984825134,
-0.03095032274723053,
0.02595764957368374,
0.040562696754932404,
-0.05227499455213547,
0.11639948189258575,
0.149179145693779,
0.023406507447361946,
-0.08201681822538376,
0.03321146219968796,
-0.0772172063589096,
-0.09809952974319458,
-0.03259546309709549,
-0.037620481103658676,
-0.02659667655825615,
0.08077224344015121,
0.06837492436170578,
0.16137532889842987,
0.006115988362580538,
-0.14588534832000732,
0.08615758270025253,
-0.1586792767047882,
-0.1329384446144104,
0.12138444930315018,
-0.06401214003562927,
-0.039040833711624146,
-0.24171660840511322,
-0.13294978439807892,
0.046797268092632294,
-0.027278393507003784,
-0.16100440919399261,
-0.1967267394065857,
-0.009511014446616173,
-0.08613768965005875,
0.008856496773660183,
-0.045734159648418427,
0.051829107105731964,
-0.006756652612239122,
0.10732589662075043,
0.09491070359945297,
0.13655675947666168,
0.08974190056324005,
0.08852465450763702,
-0.1574924886226654,
0.0018782003317028284,
0.06133473664522171,
-0.007286785636097193,
-0.046597860753536224,
-0.09129588305950165,
-0.14532865583896637,
0.05198618769645691,
0.19133102893829346,
-0.1949176788330078,
-0.003734131110832095,
0.01475547719746828,
0.12103241682052612,
0.1833195835351944,
0.10183708369731903,
0.32358869910240173,
0.19455254077911377,
-0.12929777801036835,
0.029052963480353355,
0.30765220522880554,
0.11340522766113281,
-0.00432076770812273,
-0.0005955123924650252,
0.239079087972641,
-0.02587742917239666,
0.31450536847114563,
-0.09326530247926712,
0.020714277401566505,
0.08622748404741287,
-0.165299654006958,
0.03862961381673813,
-0.073399119079113,
0.04135989397764206,
-0.09662003815174103,
-0.11028028279542923,
0.08032655715942383,
-0.17583410441875458,
-0.08618197590112686,
0.2615621089935303,
-0.08408144861459732,
-0.2222670167684555,
0.1450466364622116,
0.05919301509857178,
-0.33271706104278564,
-0.016266366466879845,
-0.17848694324493408,
0.08628826588392258,
-0.06344558298587799,
0.06372295320034027,
0.20046259462833405,
0.14932428300380707,
-0.025890078395605087,
0.15138760209083557,
0.07551959902048111,
0.000492930063046515,
-0.01788780838251114,
-0.24499568343162537,
0.05716945603489876,
-0.1586606800556183,
0.03087310492992401,
0.1958610564470291,
-0.2379920333623886,
-0.11384976655244827,
0.06895694881677628,
-0.13919763267040253,
-0.1615423560142517,
-0.1105136051774025,
-0.07986555248498917,
-0.30484312772750854,
-0.05104793980717659,
-0.16052550077438354,
0.132818803191185,
0.1303481161594391,
0.06086679548025131,
-0.016510598361492157,
0.04190239682793617,
0.005151825025677681,
0.046207599341869354,
0.0764806792140007,
-0.00005531645001610741,
-0.292803555727005,
-0.016097646206617355,
0.18790240585803986,
-0.09109961241483688,
0.22040778398513794,
-0.0682276263833046,
-0.10430997610092163,
0.016411831602454185,
0.052701059728860855,
-0.0757741928100586,
-0.13627395033836365,
-0.0789789929986,
0.20859944820404053,
0.004916864447295666,
0.23243162035942078,
0.03981652110815048,
-0.21238946914672852,
-0.47634294629096985,
0.060079459100961685,
-0.012945401482284069,
0.012953960336744785,
0.09656553715467453,
0.036517295986413956,
-0.1446375548839569,
-0.10113893449306488,
0.04025592282414436,
-0.008417962118983269,
0.034834690392017365,
-0.054769814014434814,
-0.024878639727830887,
0.19593852758407593,
-0.03393741697072983,
0.080268494784832,
-0.26190146803855896,
0.09472829848527908,
-0.009926018305122852,
-0.14835825562477112,
-0.23752668499946594,
0.009330221451818943,
0.009343716315925121,
0.11816508322954178,
-0.06403519958257675,
0.030329527333378792,
0.0011225836351513863,
-0.12278294563293457,
0.20014335215091705,
0.14194431900978088,
-0.2101963311433792,
-0.0934576690196991,
0.048936761915683746,
0.042829886078834534,
0.05307741090655327,
0.13791298866271973,
0.15362225472927094,
0.2658424973487854,
0.06296467781066895,
-0.02081926539540291,
-0.15270580351352692,
-0.24080142378807068,
-0.0749039351940155,
0.1249014362692833,
-0.17963096499443054,
-0.31945234537124634,
-0.2344874143600464,
0.3293403685092926,
0.21575018763542175,
0.026999054476618767,
-0.13811452686786652,
0.003616476431488991,
0.1304994374513626,
0.018412694334983826,
0.17166005074977875,
0.10300318896770477,
0.06463577598333359,
0.03567208722233772,
-0.12739010155200958,
-0.11223460733890533,
0.346055269241333,
0.11210881918668747,
-0.25107309222221375,
0.1533937007188797,
0.06510767340660095,
0.007872535847127438,
-0.05427751690149307,
0.0647999495267868,
0.15051384270191193,
-0.014514433220028877,
0.0009293868788518012,
0.1446877419948578,
0.0503447949886322,
-0.03246093913912773,
0.17495086789131165,
0.061425063759088516,
0.08747600018978119,
0.1412309855222702,
0.026328662410378456,
0.10268118977546692,
0.07571352273225784,
-0.15225714445114136,
0.16472846269607544,
-0.006772787310183048,
0.013126363977789879,
-0.13590984046459198,
-0.23517389595508575,
0.02656744420528412,
0.1258913278579712,
0.01488094124943018,
0.08691835403442383,
-0.05692721903324127,
-0.10057854652404785,
0.05862770229578018,
0.16897080838680267,
0.12945401668548584,
0.11540760099887848,
0.06076118350028992,
-0.04316190257668495,
0.19286412000656128,
0.08365072309970856,
0.07117333263158798,
-0.03981275111436844,
0.03967597708106041,
-0.1403951197862625,
0.11944623291492462,
0.022329019382596016,
0.1540592908859253,
-0.004247909877449274,
-0.06326102465391159,
-0.0005384490941651165,
0.02228623256087303,
-0.11852020025253296,
-0.10014332085847855,
0.07899229973554611,
-0.027865413576364517,
-0.1956898719072342,
-0.20278438925743103,
0.08178695291280746,
-0.18306361138820648,
-0.0680876225233078,
-0.0319676399230957,
0.15717531740665436,
-0.06102148815989494,
0.10488121956586838,
-0.09137937426567078,
-0.007982218638062477,
0.038761310279369354,
-0.06125951185822487,
-0.2231292426586151,
-0.16074882447719574,
0.003758782986551523,
-0.040119800716638565,
0.04372265189886093,
0.09306880086660385,
0.09416929632425308,
-0.13409686088562012,
-0.16296201944351196,
-0.21309563517570496,
-0.035096704959869385,
-0.09107732027769089,
-0.144932359457016,
-0.265592098236084,
-0.03441557660698891,
0.24215833842754364,
-0.1434899866580963,
0.2575930655002594,
-0.04538422450423241,
0.16202770173549652,
-0.1583419293165207,
-0.1612163782119751,
-0.07009381800889969,
-0.16356536746025085,
-0.14252808690071106,
-0.13619956374168396,
-0.16580449044704437,
-0.07507839053869247,
0.17503006756305695,
0.15994752943515778,
-0.06086081266403198,
-0.1492605358362198,
-0.0801566019654274,
-0.2566996216773987,
-0.08471163362264633,
-0.13957591354846954,
-0.25843241810798645,
0.2133844643831253,
-0.011876726523041725,
0.0028952164575457573,
0.24691368639469147,
0.08051761239767075,
-0.016485808417201042,
-0.058996111154556274,
0.020309414714574814,
-0.2952745258808136,
-0.0052591231651604176,
-0.09543679654598236,
-0.018033862113952637,
0.18444867432117462,
0.3078216016292572,
0.14703960716724396,
0.029226019978523254,
-0.16439417004585266,
0.12280093133449554,
-0.1869402676820755,
0.25851956009864807,
-0.06708510220050812,
-0.09125975519418716,
-0.2382415384054184,
-0.15842394530773163,
-0.20105065405368805,
-0.17775075137615204,
0.0771590918302536,
-0.0071714650839567184,
0.028198568150401115,
-0.03357623144984245,
0.07392195612192154,
-0.2680908441543579,
0.15102720260620117,
0.026336537674069405,
-0.033692266792058945,
-0.02208169363439083,
0.09387656301259995,
0.17520280182361603,
0.035754937678575516,
0.10889476537704468,
0.3089626133441925,
-0.015419607982039452,
-0.06938137859106064,
0.1890023648738861,
0.07206600159406662,
0.13359050452709198,
0.16029250621795654,
-0.010112160816788673,
0.15136906504631042,
-0.05999818444252014,
0.24759912490844727,
0.07007483392953873,
-0.009646411053836346,
0.029306568205356598,
0.03891763091087341,
0.09674419462680817,
0.055818334221839905,
0.046876754611730576,
-0.17574980854988098,
-0.0620429664850235,
-0.00043068252853117883,
0.09785521775484085,
0.16203321516513824,
-0.038316503167152405,
0.26885923743247986,
0.17517395317554474,
-0.014568968676030636,
0.09213568270206451,
-0.09037986397743225,
0.05265801027417183,
0.30283302068710327,
0.11485583335161209,
0.22883553802967072,
-0.08585347980260849,
0.03601133078336716,
0.15734462440013885,
-0.36210647225379944,
-0.04692032188177109,
-0.02999505028128624,
0.012941486202180386,
0.1723105013370514,
-0.00023524595599155873,
0.03885814547538757,
-0.01764049381017685,
-0.155775785446167,
-0.11155423521995544,
0.08519850671291351,
0.03022894822061062,
-0.049072325229644775,
-0.024239372462034225,
0.10420190542936325,
0.051669925451278687,
0.05331536754965782,
-0.09236592054367065,
0.08461219072341919,
0.009821221232414246,
0.15922322869300842,
0.010997198522090912,
0.24608446657657623,
-0.0722893700003624,
0.06683941930532455,
-0.039755452424287796,
0.0406813770532608,
0.23090872168540955,
-0.010629655793309212,
0.10841985046863556,
0.04579523578286171,
0.10866699367761612,
-0.11870448291301727,
-0.26454561948776245,
0.07806485146284103,
0.05154464766383171,
0.10706744343042374,
-0.08317454904317856,
0.09998339414596558,
0.08383436501026154,
0.029676636680960655,
-0.36893585324287415,
-0.11427316814661026,
-0.13459736108779907,
0.018619094043970108,
0.002976068062707782,
-0.020799759775400162,
-0.10650182515382767,
0.12643425166606903,
-0.1815841794013977,
-0.04201837256550789,
0.07671928405761719,
0.20102711021900177,
-0.03850257024168968,
-0.17523571848869324,
-0.14840169250965118,
0.02433113195002079,
0.0341218076646328,
0.05312125012278557,
0.10404139012098312,
0.06286348402500153,
-0.0035867751576006413,
0.05671703815460205,
0.010979895479977131,
-0.1554611176252365,
0.010424637235701084,
-0.06802111864089966,
-0.029438650235533714,
0.12340252101421356,
-0.23846735060214996,
0.07993172854185104,
-0.2951633632183075,
0.004006954841315746,
0.04497335106134415,
-0.11640599370002747,
0.19211097061634064,
0.12887078523635864,
0.10973019152879715,
-0.03957001492381096,
-0.06469187885522842,
-0.02170191891491413,
0.09265808761119843,
0.10509699583053589,
0.11859389394521713,
0.12799571454524994,
-0.11443662643432617,
-0.0770673006772995,
0.05172888562083244,
-0.1042434349656105,
-0.07549799233675003,
0.18130764365196228,
0.09364192187786102,
0.007747127674520016,
0.3104721009731293,
-0.025603031739592552,
0.053335532546043396,
-0.0756106749176979,
0.07599009573459625,
0.05804625526070595,
0.23456531763076782,
0.3047134280204773,
-0.0008715788717381656,
0.054075054824352264,
-0.16098453104496002,
-0.023800745606422424,
-0.03337864950299263,
0.16880975663661957,
-0.14609739184379578,
-0.0595327764749527,
0.09015705436468124,
-0.09017667174339294,
-0.1395818293094635,
-0.29927194118499756,
0.0812993273139,
0.19722293317317963,
-0.2153000831604004,
-0.17213080823421478,
-0.05025477334856987,
0.10980577766895294,
0.328782856464386,
0.015872210264205933,
0.17435620725154877,
0.3499792814254761,
0.16996191442012787,
0.15144602954387665,
-0.12153388559818268,
-0.0028536065947264433,
0.0006003292510285974,
0.15661919116973877,
0.038077641278505325,
-0.013617591001093388,
-0.06253638863563538,
0.17910590767860413,
0.0034617960918694735,
0.21165215969085693,
0.027798444032669067,
-0.02998955175280571,
-0.12921272218227386,
0.09939848631620407,
-0.042566314339637756,
0.2156871110200882,
-0.3194839656352997,
0.06185019761323929,
-0.08864235877990723,
-0.19067011773586273,
-0.22909663617610931,
0.17511866986751556,
0.012954682111740112,
0.2944549024105072,
-0.28933295607566833,
0.07378959655761719,
0.07036922127008438,
0.16117863357067108,
0.027673421427607536,
0.1932506561279297,
-0.15540778636932373,
0.22252388298511505,
-0.04373348504304886,
0.07644877582788467,
-0.06692972779273987,
0.02374068833887577,
-0.06826388090848923,
0.05027450621128082,
0.03271877020597458,
-0.06976760178804398,
-0.1785096973180771,
-0.03240532428026199,
-0.015320139937102795,
0.13894304633140564,
0.09349791705608368,
0.04202444478869438,
-0.021846476942300797,
-0.07799144834280014,
0.0019489628029987216,
0.0951230451464653,
0.11640587449073792,
0.08264018595218658,
0.27649879455566406,
-0.022698255255818367,
0.17946873605251312,
0.04945134371519089,
-0.1256226748228073,
-0.15158705413341522,
-0.23696832358837128,
0.03907063975930214,
0.06665977090597153,
-0.13046380877494812,
0.09706152230501175,
0.03144200146198273,
-0.03300561010837555,
0.05022730678319931,
-0.040131717920303345,
0.004693253431469202,
0.0006355482037179172,
-0.08074038475751877,
0.008814818225800991,
-0.20618052780628204,
-0.08526530861854553,
-0.04458922892808914,
0.1250068098306656,
-0.08162049949169159,
0.04824252054095268,
-0.22065135836601257,
-0.18717820942401886,
-0.22780606150627136,
-0.03215871378779411,
-0.05322825908660889,
0.05224846675992012,
-0.03853065147995949,
-0.009628119878470898,
0.17637822031974792,
-0.1484483927488327,
0.12271694093942642,
0.2636167109012604,
-0.053364772349596024,
-0.2621303200721741,
-0.16768614947795868,
-0.14354805648326874,
0.14185188710689545,
0.03309135511517525,
-0.04861413687467575,
0.012059584259986877,
0.17656266689300537,
-0.03725828230381012,
-0.044168826192617416,
-0.034338001161813736,
0.058408889919519424,
-0.03660266473889351,
-0.12917712330818176,
-0.12676866352558136,
0.27659305930137634,
0.12440980225801468,
-0.0830300971865654,
-0.047902144491672516,
-0.1496650129556656,
0.11151152104139328,
-0.07697930186986923,
0.1484827846288681,
0.21936354041099548,
-0.12351579964160919,
0.22452732920646667,
-0.11108778417110443,
-0.011241709813475609,
-0.1985379159450531,
0.010652564465999603,
0.15388524532318115,
-0.1695467084646225,
0.17063558101654053,
0.19514016807079315,
0.16428667306900024,
-0.11209239810705185,
-0.31709176301956177,
-0.13149137794971466,
-0.009916683658957481,
-0.026533782482147217,
-0.09357321262359619,
-0.08876606822013855,
-0.10615216940641403,
0.17150063812732697,
0.1500614434480667,
0.12093513458967209,
-0.22904765605926514,
0.11128759384155273,
0.09695442765951157,
0.033601827919483185,
-0.10030898451805115,
-0.31222012639045715,
-0.012315184809267521,
-0.22778163850307465,
-0.07327650487422943,
-0.11261086910963058,
-0.033408023416996,
-0.38696321845054626,
-0.11214906722307205,
0.009300366044044495,
-0.02670893631875515,
-0.04322909936308861,
0.08516822010278702,
-0.04492942616343498,
-0.23005971312522888,
0.04644102230668068,
0.20354683697223663,
0.01900513656437397,
-0.115372434258461,
0.07910595834255219,
0.0823449194431305,
0.1559683084487915,
0.15584179759025574,
-0.11663322895765305,
-0.04548637568950653,
-0.2740473449230194,
-0.08771198242902756,
-0.0025494100991636515,
0.12078870087862015,
-0.10006418824195862,
-0.17996527254581451,
0.16422006487846375,
0.07150588929653168,
-0.04626021906733513,
0.22733573615550995,
-0.007429787423461676,
0.029253611341118813
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. the brainLinear verrucous epidermal nevus (LVEN), a streaky, pigmented, rough nevus that often follows the lines of Blaschko and can be present anywhere on the bodyAdipose dysregulation including lipomatous overgrowth and lipoatrophyOther:Vascular malformations including cutaneous capillary malformations, prominent venous patterning or varicosities, and lymphatic malformationsOvergrowth of other tissues, most commonly spleen, liver, thymus, and gastrointestinal tractTumors, most commonly meningiomas. Ovarian cystadenomas, breast cancer, parotid monomorphic adenoma, mesothelioma, and others have also been reported.Bullous pulmonary degenerationDysmorphic facial features including dolichocephaly, long face, downslanting palpebral fissures, and/or minor ptosis, depressed nasal bridge, wide or anteverted nares, and open mouth at restEstablishing the DiagnosisThe diagnosis of Proteus syndrome (PS) is established in a | [
-0.1363505721092224,
-0.14274495840072632,
-0.019088013097643852,
-0.1138824000954628,
0.09915992617607117,
-0.1446436643600464,
-0.10226620733737946,
-0.03027074784040451,
-0.08323100954294205,
0.0868731439113617,
0.21457314491271973,
-0.00969818327575922,
0.0033749716822057962,
-0.003812492825090885,
-0.049309033900499344,
0.20810140669345856,
-0.27888691425323486,
-0.0974414125084877,
-0.009813575074076653,
-0.04034996032714844,
0.1480253040790558,
-0.09813213348388672,
0.044379010796546936,
0.06714744120836258,
-0.0695124939084053,
-0.13709132373332977,
0.3654012382030487,
0.37778961658477783,
0.05926735699176788,
-0.058965038508176804,
0.03617417812347412,
-0.034269705414772034,
-0.13194496929645538,
-0.31815624237060547,
0.2017093300819397,
-0.2621770203113556,
-0.3069142997264862,
0.1373155564069748,
0.04955334961414337,
-0.15205185115337372,
0.03505701571702957,
0.08523249626159668,
-0.33507323265075684,
-0.10776223242282867,
0.350506454706192,
-0.059683430939912796,
-0.08497027307748795,
0.23950962722301483,
0.1529245525598526,
0.2486640363931656,
0.24457289278507233,
-0.1852039396762848,
0.26442790031433105,
-0.09887075424194336,
0.21367962658405304,
-0.14825071394443512,
0.07873138785362244,
-0.19793151319026947,
-0.42905518412590027,
0.13601058721542358,
0.3543907701969147,
0.04164394363760948,
0.379139244556427,
-0.5323817133903503,
0.0593271404504776,
-0.09036407619714737,
-0.03588876500725746,
0.04994608834385872,
0.01882769726216793,
0.07209067791700363,
0.5722556710243225,
-0.016020797193050385,
-0.004979373887181282,
-0.08885188400745392,
-0.1308603435754776,
-0.051507193595170975,
0.14374960958957672,
-0.20361576974391937,
0.0123725775629282,
-0.07697660475969315,
-0.04880504310131073,
-0.05239240825176239,
-0.05612199753522873,
0.07327225804328918,
-0.2916894257068634,
-0.07879231125116348,
-0.046678654849529266,
-0.1118861585855484,
-0.13211679458618164,
-0.041601479053497314,
-0.06913413107395172,
0.15479621291160583,
-0.11685460805892944,
0.072323739528656,
0.0415009967982769,
-0.17650294303894043,
-0.02312356047332287,
0.04156716912984848,
-0.20226813852787018,
0.010903801769018173,
0.04600673168897629,
0.22041049599647522,
0.04400137439370155,
-0.17023630440235138,
0.07223699986934662,
-0.12222229689359665,
-0.11064475774765015,
0.06877043098211288,
0.07227320224046707,
0.09488438814878464,
-0.15840254724025726,
-0.010155766271054745,
-0.011872951872646809,
-0.232268825173378,
-0.2645743191242218,
-0.11329630017280579,
0.2236090451478958,
-0.08372329920530319,
-0.04891578108072281,
-0.0804358497262001,
0.003786506364122033,
-0.08158143609762192,
0.0026260104496032,
0.1072155013680458,
0.0874405950307846,
0.01782808266580105,
0.17455372214317322,
-0.2809583246707916,
-0.10959899425506592,
-0.1759171485900879,
0.031625162810087204,
-0.15059183537960052,
0.035264596343040466,
-0.3043563663959503,
0.019363535568118095,
0.22931401431560516,
-0.05973748862743378,
-0.034385282546281815,
0.13030055165290833,
0.10156173259019852,
0.2389220893383026,
0.0021162964403629303,
0.3954167664051056,
0.12602262198925018,
0.039645470678806305,
0.08451443165540695,
0.21123725175857544,
0.10419434309005737,
0.11505582183599472,
-0.048367928713560104,
0.31158116459846497,
-0.02096586860716343,
0.15848363935947418,
0.03362424671649933,
0.050763774663209915,
0.17677515745162964,
-0.07364168018102646,
0.12576274573802948,
-0.17948061227798462,
0.022916166111826897,
0.002002055523917079,
-0.12580369412899017,
0.16310478746891022,
-0.17658787965774536,
-0.07749011367559433,
0.20091553032398224,
0.0006008204654790461,
-0.35285818576812744,
-0.02011280693113804,
0.061821069568395615,
-0.3052063584327698,
0.03391129896044731,
-0.1535380482673645,
0.039856068789958954,
-0.19084365665912628,
0.13723166286945343,
0.0319286584854126,
0.1740318089723587,
-0.17168571054935455,
0.15977130830287933,
0.12752509117126465,
-0.05857060104608536,
-0.10115671902894974,
-0.3637172281742096,
-0.012265251949429512,
-0.07279970496892929,
-0.05467402935028076,
0.15292398631572723,
-0.2898929715156555,
0.039819538593292236,
0.054704874753952026,
-0.20735375583171844,
-0.0808124914765358,
-0.11609899252653122,
-0.16698187589645386,
-0.3154813051223755,
-0.09212127327919006,
-0.28298282623291016,
0.11477334052324295,
-0.017365122213959694,
0.11788556724786758,
-0.02305256575345993,
0.09606004506349564,
0.006241372786462307,
0.04402013123035431,
-0.04345974326133728,
0.03161372244358063,
-0.14333437383174896,
0.05269825831055641,
0.18173880875110626,
0.011935574933886528,
0.42232099175453186,
-0.1931307166814804,
-0.13622817397117615,
-0.00551091181114316,
-0.08589884638786316,
-0.10001032054424286,
-0.09797434508800507,
-0.056203074753284454,
0.19372153282165527,
-0.23693197965621948,
0.16623805463314056,
0.06447122246026993,
-0.24320168793201447,
-0.33025673031806946,
0.09720337390899658,
0.050554417073726654,
-0.1366683691740036,
0.15478968620300293,
0.11042322218418121,
-0.07946115732192993,
0.013755430467426777,
-0.06269732862710953,
0.10978683829307556,
0.07539957761764526,
-0.22828461229801178,
-0.03546612337231636,
0.3654620051383972,
-0.1505536586046219,
0.1941709667444229,
-0.15603405237197876,
-0.03536691144108772,
0.011995085515081882,
-0.022801363840699196,
-0.17943057417869568,
0.07651041448116302,
0.08798934519290924,
0.06077250465750694,
-0.057612936943769455,
0.03743254020810127,
0.07180183380842209,
-0.25642597675323486,
0.08977681398391724,
0.2203914374113083,
-0.38257914781570435,
-0.09640046954154968,
0.04292907938361168,
-0.005485726520419121,
0.13245795667171478,
0.1204223558306694,
0.2513408660888672,
0.19177615642547607,
0.1430986225605011,
-0.0565619133412838,
-0.2110677808523178,
-0.154161274433136,
0.037251491099596024,
0.19798588752746582,
-0.322742760181427,
-0.18393942713737488,
-0.1057998538017273,
0.3551739752292633,
0.08029121905565262,
0.051453638821840286,
0.020038476213812828,
-0.034005485475063324,
-0.015531999059021473,
0.041777901351451874,
0.12558653950691223,
0.15581637620925903,
0.0987863764166832,
-0.03642303869128227,
-0.20323048532009125,
-0.0809803381562233,
0.2815183699131012,
0.2808402478694916,
-0.32309508323669434,
0.1756228804588318,
-0.023494720458984375,
-0.13886681199073792,
-0.03377316892147064,
0.17642436921596527,
0.08023220300674438,
-0.12721647322177887,
0.048267289996147156,
0.4404037296772003,
-0.03031463734805584,
0.01222385372966528,
0.1522454172372818,
-0.03988846763968468,
0.1190839558839798,
0.12053153663873672,
-0.06962091475725174,
-0.03928828239440918,
0.13064777851104736,
-0.07324888557195663,
0.0655934140086174,
0.07361088693141937,
-0.014568358659744263,
-0.10272375494241714,
-0.1139993891119957,
0.16632306575775146,
0.038263797760009766,
0.1401812732219696,
0.12656426429748535,
-0.000258208776358515,
-0.20151390135288239,
-0.021435648202896118,
0.24301359057426453,
-0.029860593378543854,
-0.015079312957823277,
0.08949529379606247,
0.09847289323806763,
0.20439699292182922,
0.1563742756843567,
-0.11023140698671341,
-0.03121841885149479,
0.09666190296411514,
-0.16939017176628113,
0.2147996723651886,
0.0392552986741066,
0.018385322764515877,
0.017831776291131973,
-0.06257586181163788,
0.12018825113773346,
-0.060049012303352356,
-0.09129711240530014,
-0.07414428889751434,
0.050617728382349014,
-0.046333227306604385,
0.054466091096401215,
-0.3595956265926361,
0.09731918573379517,
-0.07313728332519531,
0.05540383607149124,
-0.02738875523209572,
0.08014248311519623,
0.1142214983701706,
0.08388137817382812,
-0.1363225281238556,
-0.04170530289411545,
-0.11385940760374069,
-0.12355846911668777,
-0.29824867844581604,
-0.05548054352402687,
0.03194224461913109,
-0.0830560103058815,
-0.05988967418670654,
-0.037338968366384506,
0.2762800455093384,
-0.0936560332775116,
-0.05027313530445099,
-0.18548822402954102,
-0.15592443943023682,
-0.05721123889088631,
0.031412459909915924,
-0.2350260466337204,
0.006443061400204897,
0.2770026624202728,
-0.15828993916511536,
0.37933552265167236,
0.3168378174304962,
0.038359206169843674,
-0.252398282289505,
-0.07343429327011108,
-0.05761723220348358,
-0.2339799553155899,
-0.09131254255771637,
-0.15013231337070465,
-0.16951745748519897,
-0.07543937116861343,
0.20869848132133484,
0.2841630280017853,
-0.1683514416217804,
-0.12488320469856262,
-0.09330432862043381,
-0.3733244836330414,
0.09939981997013092,
-0.14823020994663239,
-0.2517738938331604,
0.26291701197624207,
-0.017036886885762215,
0.004625848960131407,
0.16670189797878265,
-0.18175549805164337,
-0.03852762654423714,
0.06271489709615707,
0.0386616513133049,
-0.30875229835510254,
0.04996125027537346,
-0.13391676545143127,
-0.04253764450550079,
0.1794746369123459,
0.2694239318370819,
0.30527085065841675,
0.034389350563287735,
-0.09445194154977798,
0.06399879604578018,
-0.10775898396968842,
0.34466689825057983,
0.0007432251004502177,
-0.05359805375337601,
-0.01636248640716076,
-0.01646014116704464,
-0.27654343843460083,
-0.2582099437713623,
0.06660816818475723,
-0.011292465031147003,
0.0326860286295414,
-0.08584871888160706,
0.20743057131767273,
-0.21709489822387695,
-0.06878692656755447,
-0.09570222347974777,
-0.21289339661598206,
0.023862069472670555,
0.030667167156934738,
0.11366526782512665,
-0.012956839986145496,
0.13729985058307648,
0.2256285548210144,
-0.16042152047157288,
-0.2248058319091797,
0.04545474424958229,
0.13049115240573883,
0.22734816372394562,
0.09031466394662857,
0.053682900965213776,
0.17916829884052277,
-0.08045965433120728,
0.4470072090625763,
-0.002746275393292308,
0.05092306062579155,
0.0459124892950058,
0.04709332808852196,
0.07264743745326996,
0.13580740988254547,
0.1010725349187851,
-0.0983378142118454,
-0.0032953000627458096,
0.08852073550224304,
0.042451824992895126,
0.07708241045475006,
0.07028879225254059,
0.1923145353794098,
0.13833825290203094,
0.013687091879546642,
0.04427998140454292,
-0.024735840037465096,
0.20074334740638733,
-0.025648390874266624,
0.1498454511165619,
0.15228089690208435,
0.05788761004805565,
0.13393524289131165,
0.1687430739402771,
-0.32631927728652954,
0.07732709497213364,
0.2576849162578583,
0.14854934811592102,
-0.014300758950412273,
-0.04898403212428093,
0.24405862390995026,
0.019084352999925613,
-0.11922647058963776,
0.01654818095266819,
0.039729129523038864,
0.05965794250369072,
-0.027226915583014488,
0.1785200834274292,
0.26303380727767944,
0.09487343579530716,
0.08016440272331238,
-0.09801336377859116,
0.007255095522850752,
0.05438695102930069,
0.14237533509731293,
-0.05578751116991043,
0.3702598810195923,
0.006644261069595814,
0.2871309518814087,
0.10136941820383072,
0.0766109898686409,
0.2913833558559418,
0.08471544086933136,
0.16344523429870605,
-0.0009145559743046761,
0.11699198931455612,
-0.0038469473365694284,
-0.2581574618816376,
0.07152152806520462,
0.2233808934688568,
0.038500476628541946,
0.039807140827178955,
0.011971003375947475,
-0.06283599883317947,
-0.04956965148448944,
-0.3699307441711426,
-0.046525128185749054,
-0.07095818221569061,
0.06782398372888565,
-0.03992489352822304,
0.048996925354003906,
-0.11360406130552292,
0.23812885582447052,
-0.0040372200310230255,
-0.3077771067619324,
0.060548555105924606,
0.11093001067638397,
-0.07403717190027237,
-0.1714353710412979,
-0.12925344705581665,
0.14775283634662628,
0.02918795309960842,
-0.003272255416959524,
-0.12575633823871613,
0.025879228487610817,
0.1318955421447754,
-0.01385409850627184,
0.08574584126472473,
-0.2226310670375824,
-0.0338776670396328,
0.009027965366840363,
0.04239409789443016,
0.0383424386382103,
-0.20359960198402405,
0.04510452225804329,
-0.18244902789592743,
0.040216170251369476,
0.10111845284700394,
-0.12144094705581665,
0.22460319101810455,
0.14075130224227905,
-0.008261146023869514,
-0.015305832959711552,
0.04735589772462845,
0.07441522181034088,
0.16113153100013733,
0.08727306872606277,
0.18996386229991913,
0.13274262845516205,
-0.04876142740249634,
0.0005047889426350594,
-0.08619233965873718,
-0.1126142144203186,
-0.09959806501865387,
0.22673924267292023,
0.06674438714981079,
0.04467953369021416,
0.2553728520870209,
-0.1296427696943283,
0.06962685286998749,
-0.14503033459186554,
-0.03567986190319061,
-0.01347737293690443,
0.24676914513111115,
0.2748470604419708,
0.09142827242612839,
0.024457313120365143,
-0.013112218119204044,
-0.18289898335933685,
-0.17949187755584717,
0.23238493502140045,
-0.1851329505443573,
-0.1676289141178131,
-0.05686699226498604,
-0.17471522092819214,
-0.20821033418178558,
-0.3805156648159027,
0.026689786463975906,
0.26785677671432495,
-0.08890680968761444,
-0.15362323820590973,
-0.01948593743145466,
0.32083120942115784,
0.2904191017150879,
-0.18963153660297394,
0.302144318819046,
0.4025811553001404,
0.06712406873703003,
-0.06093498319387436,
-0.11009621620178223,
0.07772979885339737,
-0.08882181346416473,
0.08018015325069427,
-0.08214698731899261,
0.04203217104077339,
-0.06523644924163818,
0.045561086386442184,
0.03136606514453888,
0.002272919751703739,
0.05617028847336769,
-0.19252006709575653,
-0.16083525121212006,
-0.07934506982564926,
-0.03975217789411545,
0.13209547102451324,
-0.2921007573604584,
0.18617640435695648,
-0.04586993530392647,
-0.1553749293088913,
-0.31072998046875,
0.2301723212003708,
0.015346555970609188,
0.18635162711143494,
-0.25812098383903503,
0.12678162753582,
0.06401585787534714,
0.19424091279506683,
-0.010492402128875256,
0.3315369188785553,
-0.025776246562600136,
0.18750973045825958,
-0.13755884766578674,
0.014102927409112453,
0.2639025151729584,
0.0025470806285738945,
-0.07197069376707077,
0.17531521618366241,
0.0634639635682106,
-0.06040159612894058,
-0.27546563744544983,
-0.12091869860887527,
-0.02102561853826046,
0.043940551578998566,
0.2219526320695877,
0.18088163435459137,
-0.1116439700126648,
-0.006320192478597164,
-0.06239157170057297,
0.01565736159682274,
0.018989374861121178,
0.06353409588336945,
0.38715818524360657,
-0.20593810081481934,
0.3084576725959778,
-0.05150841176509857,
-0.1794191300868988,
-0.26648619771003723,
-0.4217841625213623,
-0.007948639802634716,
0.035220466554164886,
0.10245932638645172,
0.084508515894413,
0.05392933636903763,
0.11804302036762238,
-0.009469825774431229,
0.10882941633462906,
0.08238417655229568,
0.144047811627388,
-0.3067021369934082,
-0.03645806014537811,
-0.21184968948364258,
-0.11462761461734772,
0.006229896564036608,
0.11102180182933807,
-0.14454658329486847,
0.04110727459192276,
-0.273405522108078,
-0.17834249138832092,
-0.37913674116134644,
0.048511918634176254,
0.12237144261598587,
0.08272811770439148,
-0.014474209398031235,
0.13230225443840027,
0.07534125447273254,
-0.2720452547073364,
0.17393337190151215,
0.3173205554485321,
0.05330527573823929,
-0.39751580357551575,
-0.10883188247680664,
-0.2895260751247406,
0.20718513429164886,
-0.05039537698030472,
-0.18465471267700195,
-0.029469268396496773,
0.24283508956432343,
0.028846774250268936,
0.026657087728381157,
0.04285016283392906,
-0.08636466413736343,
-0.1034633219242096,
-0.05972864478826523,
-0.15278391540050507,
0.37247490882873535,
-0.0655418336391449,
-0.030977245420217514,
-0.07016434520483017,
-0.17753399908542633,
0.12243559956550598,
0.0476427897810936,
0.17941370606422424,
0.279826283454895,
-0.25750383734703064,
0.19473934173583984,
-0.11618289351463318,
0.07752406597137451,
-0.08606213331222534,
0.06427141278982162,
0.05363068729639053,
-0.1593323051929474,
0.17499984800815582,
0.14633256196975708,
0.2124747335910797,
-0.08582966029644012,
-0.17736884951591492,
-0.08595679700374603,
-0.054068610072135925,
0.09712771326303482,
-0.14951221644878387,
-0.050119515508413315,
-0.0033245510421693325,
0.1938766986131668,
-0.006045118905603886,
-0.007364731747657061,
-0.2730327546596527,
0.10218452662229538,
0.1218331903219223,
0.038899440318346024,
-0.2593142092227936,
-0.22780242562294006,
0.08470483869314194,
-0.058577269315719604,
-0.07414887100458145,
0.02411702647805214,
0.024568108841776848,
-0.2787516713142395,
-0.2112586796283722,
0.0406370647251606,
-0.18893922865390778,
-0.06958186626434326,
0.08146294951438904,
-0.09840263426303864,
-0.3243393003940582,
0.04901370778679848,
0.06479310989379883,
0.029071617871522903,
-0.038638241589069366,
0.021619483828544617,
0.026185091584920883,
0.0710524395108223,
0.164110004901886,
-0.018900202587246895,
-0.1022297814488411,
-0.1812441051006317,
-0.04367724433541298,
-0.12301011383533478,
0.2288501113653183,
-0.10302269458770752,
-0.14905062317848206,
0.09393642842769623,
-0.05954790487885475,
-0.22081515192985535,
0.20586493611335754,
0.0063765039667487144,
0.19156521558761597
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. s, most commonly meningiomas. Ovarian cystadenomas, breast cancer, parotid monomorphic adenoma, mesothelioma, and others have also been reported.Bullous pulmonary degenerationDysmorphic facial features including dolichocephaly, long face, downslanting palpebral fissures, and/or minor ptosis, depressed nasal bridge, wide or anteverted nares, and open mouth at restEstablishing the DiagnosisThe diagnosis of Proteus syndrome (PS) is established in a proband with the following general and specific criteria. Identification of a mosaic, somatic, heterozygous pathogenic variant in AKT1 by molecular genetic testing (see Table 1) can establish the diagnosis if clinical criteria are inconclusive.ALL of the following general criteria:Mosaic distribution of lesionsSporadic occurrenceProgressive courseANDSpecific criteria from categories A-C:One from category A; ORTwo from category B; ORThree from category CCategories of Specific Criteria to Establish | [
-0.1278943121433258,
0.06876880675554276,
0.06711597740650177,
-0.3665481209754944,
0.12015127390623093,
0.019495224580168724,
-0.14203011989593506,
-0.20301692187786102,
-0.06335493177175522,
0.021338244900107384,
0.19607627391815186,
-0.059263452887535095,
0.02838360145688057,
-0.03338456153869629,
-0.0857364684343338,
0.164857879281044,
-0.0025920819025486708,
0.04468885436654091,
0.022470587864518166,
0.13104183971881866,
0.06125831604003906,
0.008628441020846367,
-0.050706930458545685,
0.06326855719089508,
-0.09130149334669113,
-0.3343536853790283,
0.22313188016414642,
0.10394428670406342,
-0.0017772772116586566,
-0.08993164449930191,
0.19240686297416687,
0.013732449151575565,
-0.2208360880613327,
-0.3072395622730255,
0.03577762097120285,
-0.38721293210983276,
-0.16310782730579376,
-0.05206669121980667,
0.0967957004904747,
-0.12075662612915039,
0.03067401982843876,
-0.02730114571750164,
-0.12663398683071136,
-0.15855620801448822,
0.3738919794559479,
-0.20290477573871613,
0.19142234325408936,
0.027525199577212334,
0.19286853075027466,
0.1687169224023819,
0.16656984388828278,
-0.053351663053035736,
0.16057689487934113,
-0.14754478633403778,
0.12700729072093964,
-0.20349769294261932,
0.01504826545715332,
-0.14210060238838196,
-0.3290044367313385,
0.025972245261073112,
0.24371936917304993,
0.09952491521835327,
0.15911413729190826,
-0.4505895674228668,
0.07518244534730911,
-0.04788262024521828,
-0.09588481485843658,
0.2296302318572998,
0.29271143674850464,
-0.12100903689861298,
0.3590434491634369,
0.11818462610244751,
0.04197699949145317,
-0.13966023921966553,
0.0722619816660881,
-0.10708331316709518,
0.16530615091323853,
-0.08554011583328247,
0.12437155842781067,
-0.24682484567165375,
-0.08069851249456406,
-0.09615173190832138,
-0.17050206661224365,
0.07687322795391083,
-0.22877657413482666,
-0.06885458528995514,
-0.05281628668308258,
-0.1437515765428543,
-0.03461094945669174,
0.07886578887701035,
0.038775380700826645,
0.0444302074611187,
0.048007622361183167,
0.15218335390090942,
0.2884918749332428,
-0.08362241089344025,
0.23562662303447723,
0.2290358990430832,
-0.20590780675411224,
-0.0436331108212471,
-0.02134881541132927,
0.18386614322662354,
-0.020838389173150063,
-0.05902361869812012,
0.08073291927576065,
0.06568606942892075,
-0.15087278187274933,
0.013485980220139027,
0.13009601831436157,
0.022085562348365784,
-0.005883049685508013,
0.031958889216184616,
-0.02184256725013256,
-0.05179331451654434,
-0.12009880691766739,
-0.13911227881908417,
-0.012620564550161362,
-0.06330686062574387,
-0.17905469238758087,
0.06569568812847137,
0.04408010467886925,
-0.04669945314526558,
-0.011532437056303024,
0.12024398148059845,
-0.011899666860699654,
0.009960825555026531,
0.07191310077905655,
-0.3051275312900543,
-0.000747739861253649,
-0.09905130416154861,
0.0926927700638771,
-0.0975426733493805,
0.04821264371275902,
-0.24327614903450012,
0.13170211017131805,
0.07458160072565079,
-0.09925306588411331,
-0.11034160852432251,
0.14290893077850342,
0.09289181977510452,
0.2447267472743988,
0.18089541792869568,
0.28639745712280273,
-0.003964732401072979,
0.043820951133966446,
0.11010703444480896,
0.3454165458679199,
0.08761359751224518,
0.14859387278556824,
-0.02343515120446682,
0.1775190532207489,
0.03554157167673111,
0.10840591043233871,
0.016520466655492783,
-0.0711384117603302,
-0.10650449246168137,
-0.013782265596091747,
0.23740747570991516,
-0.10352721810340881,
0.11206892877817154,
0.05429470166563988,
-0.029287975281476974,
0.12039390951395035,
-0.05086556077003479,
0.10712897032499313,
0.13349169492721558,
-0.010668880306184292,
-0.13997182250022888,
0.10236487537622452,
-0.06891725957393646,
-0.09033782035112381,
0.014530625194311142,
-0.0871148556470871,
0.14524903893470764,
-0.09162139147520065,
0.2721160054206848,
-0.12332046031951904,
0.030991896986961365,
0.0007916653412394226,
-0.06932802498340607,
0.2494414746761322,
-0.10754390060901642,
-0.18646737933158875,
-0.2259974181652069,
-0.054975587874650955,
-0.09281062334775925,
0.06288551539182663,
0.2304837554693222,
-0.15397611260414124,
0.017927121371030807,
-0.06729759275913239,
-0.08384571969509125,
-0.15227526426315308,
-0.0753028392791748,
0.031431082636117935,
-0.34301048517227173,
0.05310835689306259,
-0.05566877871751785,
0.00463455356657505,
-0.15230268239974976,
0.07848869264125824,
-0.0787196084856987,
0.05617663636803627,
-0.10621599853038788,
0.14686456322669983,
0.07823897898197174,
0.06919459998607635,
-0.2682036757469177,
0.07788343727588654,
0.137166365981102,
-0.0021251176949590445,
0.47242480516433716,
-0.15980693697929382,
0.037573616951704025,
-0.041120994836091995,
-0.03397391736507416,
-0.13392619788646698,
-0.19664065539836884,
-0.07533669471740723,
0.19612959027290344,
-0.2356812208890915,
0.2046801596879959,
0.023516163229942322,
-0.1557960957288742,
-0.1811247020959854,
0.1615561693906784,
-0.09595005214214325,
-0.11576865613460541,
0.13081346452236176,
0.0012735696509480476,
0.037102192640304565,
-0.10536520183086395,
-0.027431730180978775,
0.188344344496727,
0.17923878133296967,
-0.30124279856681824,
-0.12704679369926453,
0.32061028480529785,
-0.10599243640899658,
0.042982317507267,
-0.15732231736183167,
-0.09377381950616837,
-0.05157456174492836,
-0.002724024932831526,
-0.04054820537567139,
0.18854239583015442,
0.05300518497824669,
0.20423202216625214,
-0.3302192986011505,
-0.08904535323381424,
0.0926947072148323,
-0.21149542927742004,
0.048416636884212494,
0.1756395846605301,
-0.27319470047950745,
-0.31340402364730835,
0.07868023961782455,
0.035569220781326294,
0.22312265634536743,
0.05316561833024025,
0.21150991320610046,
0.126799538731575,
0.21750903129577637,
0.02479838952422142,
-0.26059240102767944,
-0.1524280607700348,
0.050413914024829865,
0.22478024661540985,
-0.36203381419181824,
-0.0377514623105526,
-0.07078385353088379,
0.28119051456451416,
-0.10480710119009018,
0.23707929253578186,
-0.163044273853302,
-0.12332893908023834,
-0.03135298565030098,
0.03485605865716934,
0.025462927296757698,
0.2428205907344818,
-0.013015658594667912,
-0.10062557458877563,
-0.1726345717906952,
0.07130449265241623,
0.2786399722099304,
0.27723899483680725,
-0.28207024931907654,
-0.015022553503513336,
0.0032931058667600155,
-0.06222831830382347,
-0.06130359321832657,
0.11546771973371506,
-0.07899715006351471,
-0.06943000853061676,
0.0000496988941449672,
0.18314601480960846,
0.07309267669916153,
-0.10943449288606644,
0.20803074538707733,
-0.1456070840358734,
0.1667194366455078,
0.1789272278547287,
-0.025690540671348572,
-0.10620532929897308,
0.12803252041339874,
-0.06380091607570648,
0.2965392470359802,
-0.12934963405132294,
0.10312289744615555,
-0.1047491580247879,
-0.10634436458349228,
0.202714741230011,
-0.08051726222038269,
0.23635047674179077,
-0.06304750591516495,
0.1301691234111786,
-0.05526482313871384,
-0.02715856395661831,
0.2843887507915497,
0.08960070461034775,
-0.17764398455619812,
0.06035562977194786,
0.09578568488359451,
0.12966056168079376,
0.029353847727179527,
-0.011704896576702595,
-0.14218780398368835,
0.18922512233257294,
-0.12214454263448715,
0.17055775225162506,
-0.04492777958512306,
0.08869440108537674,
-0.09080877900123596,
0.10475392639636993,
0.2446383535861969,
-0.24226778745651245,
0.12940393388271332,
-0.07166343182325363,
-0.11455424129962921,
-0.031663406640291214,
0.045373596251010895,
-0.18307213485240936,
-0.1143006905913353,
-0.021996788680553436,
0.012184489518404007,
0.2924001216888428,
-0.10655301064252853,
0.04754636809229851,
-0.2028474360704422,
-0.1397208720445633,
0.06667521595954895,
-0.004290533717721701,
0.058192308992147446,
-0.38366732001304626,
0.1739606261253357,
-0.09988891333341599,
0.013593566603958607,
0.09160821884870529,
-0.06263475120067596,
0.24290427565574646,
-0.14416047930717468,
-0.02518412470817566,
-0.1154935359954834,
-0.05855650454759598,
-0.02061639539897442,
-0.13730488717556,
-0.17016710340976715,
0.27624592185020447,
0.19876039028167725,
0.01070175040513277,
0.24913780391216278,
0.18619614839553833,
0.008562062866985798,
-0.19804160296916962,
0.0484066866338253,
0.1305485963821411,
-0.11441176384687424,
0.10549891740083694,
-0.23939569294452667,
-0.23412999510765076,
0.08654499053955078,
0.10030537098646164,
0.238994762301445,
-0.19944193959236145,
-0.09795068949460983,
-0.044710248708724976,
-0.23904657363891602,
0.10395744442939758,
0.021583309397101402,
-0.08886457234621048,
0.09738649427890778,
-0.05630785971879959,
-0.006592547986656427,
0.007324224337935448,
-0.08077720552682877,
-0.026140796020627022,
0.17031124234199524,
-0.19962184131145477,
-0.2287546694278717,
-0.2228049635887146,
-0.024954212829470634,
-0.10474446415901184,
0.04879346117377281,
0.1872095912694931,
-0.026390062645077705,
-0.019088860601186752,
-0.03027277998626232,
0.21359111368656158,
-0.07037381827831268,
0.39244344830513,
-0.074305459856987,
-0.07196997106075287,
-0.08774539828300476,
-0.07692652940750122,
-0.03521476313471794,
-0.05869843438267708,
-0.06921374052762985,
0.017466185614466667,
-0.0719589963555336,
-0.0984855443239212,
0.2935851216316223,
0.1635579764842987,
0.0007464111549779773,
-0.17807668447494507,
-0.10547622293233871,
-0.002636938588693738,
-0.018630480393767357,
0.075680673122406,
0.08301778882741928,
0.12902241945266724,
0.05516362190246582,
-0.13164979219436646,
-0.041183117777109146,
-0.027831725776195526,
-0.020355673506855965,
0.29159224033355713,
0.1394452303647995,
0.056480806320905685,
0.06948834657669067,
-0.09792095422744751,
0.29766330122947693,
0.024705953896045685,
0.1365339308977127,
0.04133527725934982,
0.030800586566329002,
-0.004720620810985565,
0.060716189444065094,
0.012545156292617321,
-0.045008134096860886,
0.10565710812807083,
0.04380600154399872,
-0.10471596568822861,
0.05564287677407265,
-0.00034941645571962,
0.013025762513279915,
0.16932201385498047,
-0.05416640266776085,
-0.08093888312578201,
-0.0022113220766186714,
0.10241877287626266,
-0.26427391171455383,
0.029376713559031487,
0.24896468222141266,
-0.04793863743543625,
0.23264239728450775,
0.14165975153446198,
-0.1084076538681984,
0.07896600663661957,
0.150624081492424,
0.20854733884334564,
-0.024419954046607018,
0.10955553501844406,
0.15197554230690002,
0.0669284462928772,
-0.12742580473423004,
-0.08986101299524307,
0.16216307878494263,
0.1678726077079773,
0.06245826184749603,
0.040394317358732224,
0.06862536817789078,
-0.04263046011328697,
0.11129732429981232,
-0.0369640551507473,
0.017120976001024246,
0.08786237239837646,
0.18617142736911774,
-0.01782558672130108,
0.2764793634414673,
-0.02553420141339302,
0.13486029207706451,
-0.023105785250663757,
0.1355162113904953,
0.3685963451862335,
-0.08632294088602066,
-0.013142828829586506,
0.08428991585969925,
-0.0007608885644003749,
-0.04976041615009308,
-0.08476239442825317,
0.03000178560614586,
0.31944021582603455,
0.1984836310148239,
0.09227589517831802,
-0.20040611922740936,
-0.14579640328884125,
-0.027894776314496994,
-0.32895776629447937,
-0.20835815370082855,
0.03591467812657356,
-0.13493162393569946,
-0.057311657816171646,
0.11010587960481644,
-0.14544877409934998,
0.2699747681617737,
-0.06884665787220001,
-0.21494674682617188,
-0.07092850655317307,
0.13858406245708466,
-0.006097673438489437,
0.03583896905183792,
-0.06705274432897568,
0.10356921702623367,
-0.052059758454561234,
-0.040788568556308746,
-0.2599482238292694,
0.09426704794168472,
0.0926712304353714,
-0.13200466334819794,
0.05068248510360718,
-0.15772022306919098,
-0.10928983986377716,
-0.021620556712150574,
0.06722088903188705,
0.03392644226551056,
-0.06532589346170425,
0.01045772060751915,
-0.13567008078098297,
-0.08621092140674591,
0.04319098964333534,
-0.3011513650417328,
0.16517263650894165,
0.07650652527809143,
-0.2208762913942337,
0.019471829757094383,
0.01169609185308218,
0.1540217399597168,
0.12345384806394577,
0.14111946523189545,
0.19673316180706024,
-0.01439894549548626,
-0.06952981650829315,
0.0709371417760849,
-0.04014785587787628,
-0.10007545351982117,
0.031132308766245842,
-0.022316809743642807,
-0.10088715702295303,
-0.10486220568418503,
0.39673617482185364,
0.04009073227643967,
0.002621336607262492,
-0.022902751341462135,
-0.04090709984302521,
0.12571941316127777,
0.13536423444747925,
0.1868647336959839,
-0.009354334324598312,
-0.03691069036722183,
-0.023743851110339165,
-0.18007297813892365,
-0.06635332107543945,
0.09955095499753952,
-0.20335987210273743,
-0.06669650971889496,
0.006889920681715012,
-0.10075342655181885,
-0.13388311862945557,
-0.28389978408813477,
0.0331680104136467,
0.20743581652641296,
-0.1944231241941452,
-0.15294010937213898,
-0.23736101388931274,
0.2909172475337982,
0.2554013133049011,
-0.09112026542425156,
0.15118029713630676,
0.25703945755958557,
-0.11895637959241867,
-0.004165286663919687,
-0.07387261837720871,
0.18761558830738068,
0.061766985803842545,
0.0035164065193384886,
-0.10443229973316193,
0.23660098016262054,
0.0012667655246332288,
0.024617215618491173,
0.053971391171216965,
-0.12501026690006256,
-0.0006251293234527111,
-0.3278259336948395,
-0.05967249348759651,
0.06364421546459198,
-0.0567130483686924,
0.12562882900238037,
-0.2484348863363266,
0.10356102138757706,
-0.04409703239798546,
-0.1659693419933319,
-0.144803985953331,
0.09036121517419815,
-0.0969904288649559,
0.1327822357416153,
-0.23279225826263428,
0.11173008382320404,
0.04494664445519447,
0.28191816806793213,
-0.0044325487688183784,
0.27972766757011414,
-0.014416737481951714,
0.18251053988933563,
-0.26475048065185547,
-0.12533321976661682,
0.2938786447048187,
-0.007592965383082628,
-0.09062539786100388,
0.09403730928897858,
0.08479728549718857,
-0.1563636064529419,
-0.06908697634935379,
-0.19757986068725586,
0.10178956389427185,
-0.07873104512691498,
0.10423224419355392,
0.07927394658327103,
-0.2392188012599945,
-0.009452675469219685,
-0.024956904351711273,
0.0490783154964447,
-0.03661108389496803,
0.021798554807901382,
0.17367520928382874,
-0.3661743700504303,
-0.010633942671120167,
-0.052822403609752655,
-0.14261683821678162,
-0.20235897600650787,
-0.327886700630188,
-0.1971997767686844,
0.07844475656747818,
0.12025562673807144,
0.08505723625421524,
0.2579781413078308,
-0.06566924601793289,
0.14923514425754547,
0.11702154576778412,
0.1322309672832489,
0.12917181849479675,
-0.2163247913122177,
0.012574940919876099,
-0.07995927333831787,
-0.08035159111022949,
0.16621454060077667,
0.0755656510591507,
-0.09663482755422592,
0.31668543815612793,
-0.21916158497333527,
-0.037237681448459625,
-0.3873143494129181,
0.1966782957315445,
0.10415027290582657,
0.12592606246471405,
0.13605830073356628,
0.09955579042434692,
0.02458534575998783,
-0.14871016144752502,
0.027893783524632454,
0.36435917019844055,
0.05223226919770241,
-0.45167431235313416,
-0.09763859957456589,
-0.15552489459514618,
0.18981942534446716,
0.024663321673870087,
-0.252210408449173,
-0.11802731454372406,
0.13748003542423248,
-0.07136333733797073,
-0.04956578463315964,
-0.06837509572505951,
-0.17441222071647644,
-0.05810844525694847,
-0.011513504199683666,
-0.07040765136480331,
0.5268660187721252,
-0.12070882320404053,
0.000028333166483207606,
-0.07236499339342117,
0.012804078869521618,
0.04488670453429222,
0.03399794548749924,
0.13243435323238373,
0.1332346498966217,
-0.20733286440372467,
0.28602302074432373,
-0.220913365483284,
0.12004566192626953,
0.0020466623827815056,
-0.017849206924438477,
-0.22419904172420502,
-0.05173728987574577,
0.14777499437332153,
-0.08717161417007446,
0.2934694290161133,
-0.3014000356197357,
0.14975205063819885,
-0.029645947739481926,
-0.0614304319024086,
-0.06892669200897217,
0.028485149145126343,
0.14939959347248077,
-0.08047179877758026,
0.2326825112104416,
-0.03243259713053703,
0.19630324840545654,
0.021826812997460365,
-0.03928740322589874,
-0.007604885380715132,
0.0411352664232254,
-0.13623884320259094,
-0.16364219784736633,
0.14726854860782623,
-0.05803663656115532,
-0.011788385920226574,
0.2049349844455719,
-0.010871377773582935,
-0.023759737610816956,
-0.35801446437835693,
0.18045979738235474,
-0.11661899834871292,
-0.03199564293026924,
-0.06713219732046127,
-0.012640580534934998,
-0.12210862338542938,
-0.03775017708539963,
-0.04886661097407341,
-0.08896132558584213,
-0.009593760594725609,
0.1686607003211975,
0.06935379654169083,
0.12338882684707642,
-0.00997202843427658,
-0.05519193038344383,
-0.18028917908668518,
-0.12460940331220627,
-0.21409475803375244,
-0.03440893441438675,
-0.012166633270680904,
-0.0563519261777401,
0.03169141709804535,
-0.16261227428913116,
0.1364130824804306,
-0.23590423166751862,
0.2198868989944458,
-0.02707105316221714,
0.25635915994644165
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. ) is established in a proband with the following general and specific criteria. Identification of a mosaic, somatic, heterozygous pathogenic variant in AKT1 by molecular genetic testing (see Table 1) can establish the diagnosis if clinical criteria are inconclusive.ALL of the following general criteria:Mosaic distribution of lesionsSporadic occurrenceProgressive courseANDSpecific criteria from categories A-C:One from category A; ORTwo from category B; ORThree from category CCategories of Specific Criteria to Establish the Diagnosis of Proteus SyndromeCategory A. Cerebriform connective tissue nevus (CCTN). See Suggestive Findings.Category BLinear epidermal nevusAsymmetric, disproportionate overgrowth (≥1 of the following):Note: Asymmetric, disproportionate overgrowth should be carefully distinguished from asymmetric, proportionate, or ballooning overgrowth.LimbsHyperostosis of the skullHyperostosis of the external auditory canalMegaspondylodysplasia (i.e., abnormal growth of vertebrae | [
-0.17883369326591492,
0.026317285373806953,
-0.03240208700299263,
-0.322945773601532,
0.09056220203638077,
0.030066872015595436,
-0.10206849873065948,
-0.1622655838727951,
-0.028716914355754852,
0.1110898032784462,
0.2581835389137268,
0.05017977952957153,
-0.04399114102125168,
-0.03799372538924217,
-0.21857579052448273,
0.3054094910621643,
0.0014541068812832236,
-0.1157064214348793,
-0.0868338793516159,
0.11496326327323914,
0.053573668003082275,
0.0039509860798716545,
-0.0015938673168420792,
-0.026155859231948853,
-0.06101284176111221,
-0.19320501387119293,
0.15547575056552887,
0.2455907016992569,
-0.045021601021289825,
-0.11174727976322174,
0.03202960640192032,
0.055077627301216125,
-0.1682501584291458,
-0.32072168588638306,
0.03446897491812706,
-0.3022565245628357,
-0.3236891031265259,
-0.02646287903189659,
0.13159728050231934,
-0.09128735959529877,
-0.0034634408075362444,
0.06513193994760513,
-0.16106468439102173,
-0.1540769636631012,
0.279254674911499,
-0.10985257476568222,
0.04969120770692825,
0.10909855365753174,
0.21863248944282532,
0.26850417256355286,
0.1866219937801361,
-0.021658428013324738,
0.11726169288158417,
-0.11735757440328598,
0.16543130576610565,
-0.20970578491687775,
0.0211795624345541,
-0.2090267837047577,
-0.5570937395095825,
0.01315829623490572,
0.19973155856132507,
0.17354728281497955,
0.2538864314556122,
-0.30654647946357727,
0.06202033907175064,
-0.24281741678714752,
-0.13195770978927612,
0.12318132817745209,
0.20508353412151337,
0.015497931279242039,
0.32912904024124146,
0.02169460989534855,
-0.11418499797582626,
-0.12911321222782135,
-0.16201061010360718,
-0.09367964416742325,
0.2043556272983551,
-0.058222755789756775,
0.14292338490486145,
-0.3205181956291199,
-0.05743226781487465,
-0.11622486263513565,
-0.06127952039241791,
0.1011241152882576,
-0.20578603446483612,
-0.07893399149179459,
0.04101855307817459,
-0.03148231282830238,
0.03664695471525192,
0.08955175429582596,
0.07441463321447372,
0.06023760512471199,
-0.06857381761074066,
0.15364032983779907,
0.19744889438152313,
-0.16975876688957214,
0.14268167316913605,
0.035086020827293396,
-0.16393160820007324,
-0.019984764978289604,
0.15024706721305847,
0.28134921193122864,
-0.028812723234295845,
-0.09890266507863998,
0.11726014316082001,
-0.04398391768336296,
-0.07459226995706558,
0.01009451039135456,
0.07412325590848923,
-0.05231495201587677,
-0.14001011848449707,
-0.03441840782761574,
-0.042799390852451324,
-0.04672949016094208,
-0.17943806946277618,
-0.2479686737060547,
0.1548025757074356,
-0.09415790438652039,
-0.0746607854962349,
0.023554479703307152,
-0.052693530917167664,
-0.021442821249365807,
0.04800906032323837,
0.06568997353315353,
0.047576598823070526,
0.12037833780050278,
0.12159667164087296,
-0.3537518084049225,
-0.1117725595831871,
-0.2633194029331207,
0.017341626808047295,
-0.044466596096754074,
-0.02245890349149704,
-0.31079739332199097,
0.11656013876199722,
0.16584531962871552,
-0.08859284967184067,
-0.09850404411554337,
0.09625671058893204,
0.08472238481044769,
0.20919987559318542,
0.07259388267993927,
0.1786619871854782,
0.03863518685102463,
-0.00034460736787877977,
0.05270833894610405,
0.24653314054012299,
0.009967595338821411,
0.04979982227087021,
-0.041066911071538925,
0.31237637996673584,
-0.03169645369052887,
0.25981515645980835,
0.15750373899936676,
0.08284854888916016,
-0.10704457014799118,
0.039305560290813446,
0.16584298014640808,
-0.05093953013420105,
0.06528709083795547,
0.025480734184384346,
0.020832566544413567,
0.0210847370326519,
-0.176936075091362,
0.007427002768963575,
0.20061810314655304,
0.011133394204080105,
-0.09500309824943542,
0.04921432584524155,
0.0018498513381928205,
-0.15490315854549408,
0.04051417484879494,
-0.09452107548713684,
0.21674680709838867,
0.025531744584441185,
0.08069238811731339,
0.08380549401044846,
0.05844096094369888,
-0.05051853507757187,
0.12102822214365005,
0.16675080358982086,
-0.0014819101197645068,
0.05519063025712967,
-0.2568484842777252,
-0.09220196306705475,
-0.009264208376407623,
0.064166359603405,
0.21492069959640503,
-0.25404173135757446,
0.031379397958517075,
0.1257735788822174,
-0.11707485467195511,
-0.23404958844184875,
-0.13770584762096405,
-0.04339655861258507,
-0.1602853685617447,
-0.06535453349351883,
-0.010693288408219814,
0.07714719325304031,
-0.028991494327783585,
0.03843304142355919,
-0.01805342733860016,
0.13207226991653442,
-0.052228640764951706,
0.17402616143226624,
0.07693181186914444,
0.06435976922512054,
-0.22076120972633362,
0.10448900610208511,
0.11367184668779373,
0.052464794367551804,
0.4212748110294342,
-0.16662989556789398,
0.01852472685277462,
-0.03226802498102188,
-0.071285180747509,
-0.06874004006385803,
-0.0930669754743576,
-0.09442179650068283,
0.30307111144065857,
-0.2295835316181183,
0.22488369047641754,
0.006760432384908199,
-0.19144253432750702,
-0.18621718883514404,
0.08422531932592392,
0.11510705947875977,
-0.10888950526714325,
0.028401454910635948,
0.011966388672590256,
-0.03444969281554222,
-0.07529868930578232,
-0.07349877059459686,
0.06283215433359146,
0.093182273209095,
-0.21721400320529938,
-0.1617095023393631,
0.19148501753807068,
-0.0359305664896965,
0.1132013350725174,
-0.049450553953647614,
0.05961179733276367,
-0.07562410831451416,
-0.029330726712942123,
0.015512000769376755,
0.14774024486541748,
0.09496886283159256,
0.031186219304800034,
-0.23221571743488312,
0.057724129408597946,
0.1283818930387497,
-0.25182944536209106,
0.19923852384090424,
0.0878128856420517,
-0.24643808603286743,
-0.23142895102500916,
0.096279576420784,
0.02410823106765747,
0.14726807177066803,
0.11065539717674255,
0.2737092971801758,
0.2453695833683014,
0.22622020542621613,
0.055511943995952606,
-0.22378990054130554,
-0.11434011906385422,
-0.11220663040876389,
0.1825259029865265,
-0.23287634551525116,
-0.1643422693014145,
-0.10418356955051422,
0.27302980422973633,
0.03353961557149887,
0.1782386600971222,
-0.05084137246012688,
0.07013174891471863,
0.09900953620672226,
0.09246329218149185,
0.06582609564065933,
0.19399894773960114,
0.0793430358171463,
-0.14846336841583252,
-0.06805812567472458,
0.05295803025364876,
0.2897886037826538,
0.07830959558486938,
-0.410222589969635,
0.09977482259273529,
-0.006721124053001404,
-0.05070267990231514,
0.0049196332693099976,
0.057332612574100494,
0.029422912746667862,
-0.1523848921060562,
-0.023944690823554993,
0.1831522285938263,
-0.02957489714026451,
0.01955653727054596,
0.20219723880290985,
-0.1323302686214447,
0.17984794080257416,
0.08180265873670578,
-0.15601155161857605,
-0.0961158350110054,
-0.0157802514731884,
-0.20775604248046875,
0.30854088068008423,
-0.14728595316410065,
0.1303917020559311,
-0.13739809393882751,
-0.02519177831709385,
0.2053750604391098,
0.0800648033618927,
0.12012125551700592,
-0.15860936045646667,
-0.004673379473388195,
-0.11461907625198364,
-0.04920777678489685,
0.3711837828159332,
0.018559807911515236,
0.04678468406200409,
0.04703821986913681,
0.12606213986873627,
0.09457148611545563,
-0.013901565223932266,
-0.017629573121666908,
-0.13665105402469635,
0.05603015422821045,
-0.074759341776371,
0.13246376812458038,
0.06796430051326752,
0.07246668636798859,
-0.020820654928684235,
-0.03444565087556839,
0.09094260632991791,
-0.011884170584380627,
0.03683299571275711,
-0.08866094052791595,
-0.008951916359364986,
0.03334864228963852,
-0.0702977254986763,
-0.32163870334625244,
-0.010001699440181255,
-0.07672274112701416,
-0.03697649762034416,
0.05905301123857498,
-0.07032544165849686,
-0.005274921655654907,
-0.09489606320858002,
-0.10025004297494888,
0.0007591124740429223,
-0.12163205444812775,
0.04773857071995735,
-0.2265755981206894,
0.09160008281469345,
0.022466134279966354,
0.24897199869155884,
0.11342073976993561,
-0.12989328801631927,
0.15268518030643463,
-0.13331420719623566,
0.038052480667829514,
-0.33050933480262756,
-0.0386093333363533,
-0.06335966289043427,
-0.11955217272043228,
-0.3562573492527008,
0.17212294042110443,
0.2401612102985382,
-0.03213775157928467,
0.3520928621292114,
0.06907512247562408,
0.11422748863697052,
-0.08061759918928146,
0.13711413741111755,
0.06521108001470566,
-0.0701940581202507,
0.052966997027397156,
-0.1896304190158844,
-0.23977090418338776,
-0.004684692248702049,
0.11447547376155853,
0.3365228474140167,
-0.1722574084997177,
-0.13761599361896515,
0.026540694758296013,
-0.3368436396121979,
0.03468572348356247,
-0.00983138382434845,
-0.122652567923069,
0.2523159384727478,
-0.019645031541585922,
-0.14545243978500366,
0.11736743152141571,
-0.005673106759786606,
-0.07428359240293503,
0.07931172847747803,
-0.11660671979188919,
-0.23596076667308807,
-0.16380998492240906,
0.019749660044908524,
-0.057470351457595825,
0.04908011481165886,
0.1677878350019455,
0.02821616642177105,
0.06866779178380966,
-0.02081751637160778,
0.1378861367702484,
-0.03604695573449135,
0.36894065141677856,
-0.199115589261055,
-0.08882699906826019,
-0.06381846964359283,
-0.09101744741201401,
0.07254062592983246,
-0.16145604848861694,
0.017014581710100174,
0.03140786290168762,
0.050711363554000854,
-0.14632074534893036,
0.20907819271087646,
-0.16537390649318695,
0.13348153233528137,
-0.10378210991621017,
0.03577665239572525,
0.040217075496912,
-0.008999143727123737,
0.06901273876428604,
-0.037965405732393265,
0.03711104020476341,
0.26666292548179626,
-0.059504084289073944,
-0.14377661049365997,
0.02403382584452629,
0.021069101989269257,
0.20069520175457,
0.08175037056207657,
0.08922862261533737,
0.04489074647426605,
-0.12364106625318527,
0.41211259365081787,
0.07200224697589874,
0.0701981633901596,
-0.025200145319104195,
-0.061495695263147354,
0.11218657344579697,
0.059790126979351044,
0.12869355082511902,
0.005277214106172323,
0.05665839463472366,
0.06730034202337265,
0.08252210915088654,
0.116236113011837,
-0.025663066655397415,
0.09216106683015823,
0.07234989106655121,
-0.05050264298915863,
-0.08859144896268845,
-0.11142370849847794,
0.13857538998126984,
-0.07078222185373306,
0.16244137287139893,
0.24432428181171417,
-0.04421383887529373,
0.07757747918367386,
0.1677471548318863,
-0.29961174726486206,
0.09167908877134323,
0.25640690326690674,
0.12336812168359756,
-0.06126490235328674,
0.05077407509088516,
0.2552264630794525,
-0.02877388708293438,
-0.04159343242645264,
0.02278566174209118,
0.05001410096883774,
0.0654185488820076,
0.04545840248465538,
0.015184596180915833,
0.22277601063251495,
-0.03145419806241989,
0.08969251811504364,
0.018412113189697266,
0.13349416851997375,
0.07924606651067734,
-0.05911952257156372,
-0.08267360180616379,
0.24776481091976166,
-0.16692645847797394,
0.1877284198999405,
0.022758323699235916,
0.03746677562594414,
0.4135407507419586,
0.016349324956536293,
-0.002452700398862362,
0.06615716964006424,
0.08379293233156204,
-0.061793722212314606,
-0.0822763741016388,
-0.01596182771027088,
0.26369887590408325,
0.1838015913963318,
0.03327750787138939,
-0.13719120621681213,
-0.03240321949124336,
-0.10477202385663986,
-0.3839702606201172,
-0.2168322503566742,
0.06505715101957321,
-0.15917034447193146,
-0.004205585923045874,
0.08938517421483994,
-0.10341732949018478,
0.1250249743461609,
-0.08072827756404877,
-0.10656480491161346,
-0.13464711606502533,
0.07569807767868042,
0.040696848183870316,
0.008166900835931301,
-0.09225699305534363,
0.011884071864187717,
0.023224404081702232,
-0.02184406667947769,
-0.18566040694713593,
0.010222209617495537,
0.11705727130174637,
-0.14867030084133148,
0.1520271599292755,
-0.173902228474617,
-0.09799624234437943,
0.0989602729678154,
-0.011025573126971722,
0.137337327003479,
-0.13964669406414032,
-0.08038447052240372,
-0.059837646782398224,
-0.16334268450737,
0.12910662591457367,
-0.2484278380870819,
0.20622554421424866,
0.15947319567203522,
-0.1102343499660492,
0.022168844938278198,
-0.00035975914215669036,
0.0736646056175232,
0.1605375111103058,
0.07512494921684265,
0.24480468034744263,
-0.030311791226267815,
-0.04490120708942413,
0.0921698808670044,
-0.058008454740047455,
-0.16844937205314636,
-0.023314757272601128,
0.08457474410533905,
0.08435498923063278,
-0.0535615049302578,
0.37346014380455017,
-0.01796308346092701,
0.13278302550315857,
-0.06982336938381195,
-0.10575059056282043,
0.012932251207530499,
0.14343906939029694,
0.2727605700492859,
-0.05284389108419418,
-0.030572568997740746,
0.06815232336521149,
-0.13663072884082794,
-0.04242085665464401,
0.22886189818382263,
-0.2436448633670807,
-0.0033113376703113317,
0.07684839516878128,
0.003310663625597954,
-0.10724548995494843,
-0.34735041856765747,
0.14706525206565857,
0.2563910484313965,
-0.19470980763435364,
-0.044617801904678345,
-0.20621316134929657,
0.02072688564658165,
0.34888598322868347,
-0.15104074776172638,
0.12239696085453033,
0.3454943895339966,
-0.04190029203891754,
-0.050053760409355164,
-0.12022727727890015,
0.13073138892650604,
0.13023152947425842,
0.052517201751470566,
-0.10442064702510834,
0.26456528902053833,
0.00298504950478673,
0.10531693696975708,
-0.037121955305337906,
-0.0065230391919612885,
-0.06395944952964783,
-0.16586934030056,
-0.14608988165855408,
0.03674390912055969,
-0.12325828522443771,
0.040129292756319046,
-0.26219794154167175,
0.1889360100030899,
-0.1474924087524414,
-0.22164402902126312,
-0.19244487583637238,
0.02904363162815571,
-0.022842565551400185,
0.16128943860530853,
-0.1436762809753418,
0.13704060018062592,
-0.027689404785633087,
0.17187783122062683,
0.07741143554449081,
0.2808593809604645,
-0.09059704095125198,
0.06889443844556808,
-0.27204278111457825,
-0.025525137782096863,
0.27386945486068726,
-0.01159632857888937,
-0.11807245761156082,
0.13383974134922028,
0.006245082709938288,
-0.012283993884921074,
-0.012396222911775112,
-0.11815248429775238,
0.06258964538574219,
0.030840417370200157,
0.1322995275259018,
0.02720577083528042,
-0.027060113847255707,
-0.10925956070423126,
-0.1059517040848732,
0.004062785301357508,
-0.05375593528151512,
-0.008637540973722935,
0.23597726225852966,
-0.2237503081560135,
0.16618382930755615,
-0.04712381213903427,
-0.04170152172446251,
-0.09109609574079514,
-0.2663050591945648,
-0.06038541719317436,
0.11838460713624954,
0.11642351001501083,
0.06984224170446396,
0.18934942781925201,
0.006482280790805817,
0.22645021975040436,
0.03353122994303703,
0.13566277921199799,
-0.03304118663072586,
-0.14445288479328156,
-0.015426071360707283,
-0.1301501840353012,
-0.09151501953601837,
0.12902553379535675,
0.11542169749736786,
-0.03488221392035484,
0.14653323590755463,
-0.19560524821281433,
-0.20088881254196167,
-0.4066316783428192,
0.09607058763504028,
0.07141730934381485,
0.015264765359461308,
0.03773568570613861,
0.0541587769985199,
0.2223791927099228,
-0.1656513661146164,
0.0722055435180664,
0.35625237226486206,
0.01077120192348957,
-0.2820945382118225,
-0.09584666788578033,
-0.09387005120515823,
0.14192134141921997,
-0.0805787518620491,
-0.20933595299720764,
-0.03262384608387947,
0.18516969680786133,
0.03825988620519638,
-0.038936249911785126,
-0.005584751255810261,
-0.10020525753498077,
-0.1600806713104248,
0.01804909110069275,
-0.2350064069032669,
0.4270697236061096,
0.01783665083348751,
-0.02867819368839264,
-0.0011024009436368942,
-0.024370599538087845,
0.01388854905962944,
0.040863677859306335,
0.12311998754739761,
0.16215874254703522,
-0.19846951961517334,
0.2095395177602768,
-0.19522683322429657,
0.04376420006155968,
-0.16960152983665466,
-0.05698886513710022,
-0.07976758480072021,
-0.11485888808965683,
0.11765886843204498,
-0.0258000660687685,
0.19112564623355865,
-0.17296364903450012,
-0.030403487384319305,
-0.0810680091381073,
0.000331568211549893,
-0.09559563547372818,
-0.026161741465330124,
0.05979735031723976,
-0.09921347349882126,
0.16512124240398407,
-0.12262613326311111,
0.05592501908540726,
-0.13968801498413086,
0.15706965327262878,
0.03741609305143356,
0.011114281602203846,
-0.14316773414611816,
-0.12958745658397675,
-0.09271302819252014,
-0.04840230569243431,
0.017069604247808456,
0.23105448484420776,
-0.11781476438045502,
-0.0927838385105133,
-0.2662432789802551,
0.09518485516309738,
-0.03176945820450783,
-0.0011174629908055067,
0.05562817305326462,
0.05413180589675903,
-0.04568742215633392,
0.06509675830602646,
-0.04409673064947128,
-0.003353044157847762,
-0.15830810368061066,
0.1144375130534172,
0.14789508283138275,
0.1162068322300911,
0.0532904751598835,
-0.13334141671657562,
-0.1591348797082901,
-0.16450516879558563,
-0.1044556125998497,
-0.046750571578741074,
0.12301765382289886,
-0.02945205196738243,
-0.211660698056221,
-0.026349131017923355,
-0.015721796080470085,
-0.16181649267673492,
0.15994028747081757,
0.07724874466657639,
0.06373386830091476
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. of Specific Criteria to Establish the Diagnosis of Proteus SyndromeCategory A. Cerebriform connective tissue nevus (CCTN). See Suggestive Findings.Category BLinear epidermal nevusAsymmetric, disproportionate overgrowth (≥1 of the following):Note: Asymmetric, disproportionate overgrowth should be carefully distinguished from asymmetric, proportionate, or ballooning overgrowth.LimbsHyperostosis of the skullHyperostosis of the external auditory canalMegaspondylodysplasia (i.e., abnormal growth of vertebrae)Viscera: spleen/thymusSpecific tumors with onset before the second decade (either of the following):Bilateral ovarian cystadenomaParotid monomorphic adenomaCategory CDysregulated adipose tissue (either of the following):Lipomatous overgrowthRegional lipoatrophyVascular malformations (one of the following):Capillary malformationVenous malformationLymphatic malformationBullous pulmonary degenerationFacial phenotype (all of the following): | [
-0.19413918256759644,
-0.08039790391921997,
-0.10451000183820724,
-0.2103516012430191,
0.09510097652673721,
0.029313165694475174,
-0.10834893584251404,
-0.07215780019760132,
-0.020432377234101295,
0.1428731232881546,
0.33334633708000183,
0.07546984404325485,
0.03431610390543938,
-0.011446608230471611,
-0.3058576285839081,
0.31036296486854553,
-0.15491130948066711,
-0.08468444645404816,
-0.13410094380378723,
0.09221786260604858,
0.004862142726778984,
-0.01718168891966343,
0.00025587156414985657,
0.05292073264718056,
-0.09647172689437866,
-0.17673367261886597,
0.1707189381122589,
0.31927159428596497,
-0.0654960572719574,
-0.06494790315628052,
0.010674653574824333,
0.09849611669778824,
-0.20233695209026337,
-0.4122200608253479,
0.0584753192961216,
-0.2939232885837555,
-0.37248310446739197,
-0.02827964350581169,
0.052179984748363495,
-0.13801012933254242,
-0.05956387147307396,
0.030561242252588272,
-0.19512709975242615,
-0.09678477048873901,
0.30517229437828064,
-0.05420951172709465,
-0.04221147671341896,
0.12178587168455124,
0.15397417545318604,
0.263985276222229,
0.2277088761329651,
-0.06935355067253113,
0.16510508954524994,
-0.1199042871594429,
0.19174937903881073,
-0.2831881046295166,
-0.04545104131102562,
-0.16765263676643372,
-0.6554613709449768,
0.13974213600158691,
0.27085810899734497,
0.11608551442623138,
0.24262022972106934,
-0.3910314738750458,
0.0051835887134075165,
-0.2305433750152588,
-0.11873368918895721,
0.09250765293836594,
0.07555409520864487,
0.051913321018218994,
0.4462398290634155,
0.04923848435282707,
-0.17717653512954712,
-0.13414952158927917,
-0.1507556140422821,
-0.09849970042705536,
0.1703186184167862,
-0.18595218658447266,
0.15616004168987274,
-0.25370854139328003,
-0.00012812427303288132,
-0.012376419268548489,
-0.05657690390944481,
0.002542714588344097,
-0.19452808797359467,
-0.063317209482193,
0.02599853277206421,
-0.0943780466914177,
0.04132461175322533,
-0.01874137669801712,
0.1338331401348114,
0.007445137947797775,
0.04991254583001137,
0.15303778648376465,
0.12196628749370575,
-0.21493865549564362,
0.10712830722332001,
-0.03525339439511299,
-0.16921266913414001,
-0.05350273475050926,
0.10524801164865494,
0.3049498200416565,
0.05787814036011696,
-0.11952248215675354,
0.08020996302366257,
-0.12275148928165436,
-0.013107392005622387,
0.049519285559654236,
0.1383756548166275,
0.018026059493422508,
-0.17214316129684448,
-0.008086537010967731,
0.02073073387145996,
-0.08030889928340912,
-0.20327630639076233,
-0.2439994513988495,
0.19234363734722137,
-0.10327416658401489,
-0.059701088815927505,
-0.022708913311362267,
0.015356524847447872,
-0.017567753791809082,
0.04911071062088013,
0.10725034773349762,
0.08345148712396622,
0.18945476412773132,
0.1512536108493805,
-0.3625650107860565,
-0.08947206288576126,
-0.2612287998199463,
-0.016656385734677315,
-0.16833829879760742,
-0.06073816865682602,
-0.346085786819458,
0.06105852499604225,
0.21967019140720367,
-0.03838910162448883,
-0.11663348227739334,
0.12953031063079834,
0.07197621464729309,
0.265679270029068,
-0.0013347470667213202,
0.2768097519874573,
0.06315674632787704,
0.042433612048625946,
0.027003798633813858,
0.21153174340724945,
0.02504066191613674,
0.08924521505832672,
-0.10064493864774704,
0.36521995067596436,
-0.030709799379110336,
0.17416886985301971,
0.1297537088394165,
0.13885393738746643,
-0.10360074043273926,
0.05046064406633377,
0.1260189563035965,
0.03780994936823845,
0.0610538050532341,
0.025085153058171272,
-0.030502231791615486,
0.023413505405187607,
-0.19945621490478516,
-0.10391352325677872,
0.3109726011753082,
0.0499604158103466,
-0.20670685172080994,
-0.009706451557576656,
-0.007755605969578028,
-0.18605129420757294,
0.03294917196035385,
-0.21731433272361755,
0.14229929447174072,
-0.11524196714162827,
0.07224010676145554,
0.0830221027135849,
0.10920586436986923,
-0.038158517330884933,
0.18966150283813477,
0.14998193085193634,
0.027502793818712234,
0.056124672293663025,
-0.34845292568206787,
-0.16210994124412537,
-0.09819113463163376,
-0.00014304505020845681,
0.18771882355213165,
-0.2343926578760147,
-0.0009445439791306853,
0.12478221952915192,
-0.20887483656406403,
-0.17397025227546692,
-0.08026889711618423,
-0.04406864568591118,
-0.2123071849346161,
-0.07394633442163467,
-0.035320986062288284,
0.10949882119894028,
0.09251851588487625,
0.07482599467039108,
-0.014366108924150467,
0.23860453069210052,
-0.05624203011393547,
0.07531261444091797,
0.019348306581377983,
0.018851272761821747,
-0.1981484293937683,
0.11389215290546417,
0.11986061930656433,
0.02350727654993534,
0.4583016335964203,
-0.11796654760837555,
-0.03816836327314377,
0.05556170642375946,
-0.07163555920124054,
-0.19152413308620453,
-0.12393900007009506,
-0.12271499633789062,
0.3687732517719269,
-0.22960132360458374,
0.27494433522224426,
0.016715386882424355,
-0.2638840675354004,
-0.283385306596756,
0.10426580160856247,
0.07748617231845856,
-0.10958452522754669,
0.024943703785538673,
0.09035127609968185,
-0.13800112903118134,
-0.02033444494009018,
-0.03648112341761589,
0.1724224090576172,
0.11295021325349808,
-0.2976728081703186,
-0.2255277931690216,
0.229347363114357,
0.038430292159318924,
0.22269123792648315,
-0.040423594415187836,
-0.006839858368039131,
-0.05902715027332306,
0.04433281719684601,
-0.10585261881351471,
0.14965997636318207,
0.006377690006047487,
0.01023771520704031,
-0.17667914927005768,
0.025355791673064232,
0.13853906095027924,
-0.25942152738571167,
0.24159671366214752,
0.05664569512009621,
-0.2262689769268036,
-0.1553603857755661,
0.18548671901226044,
0.005501369945704937,
0.09282248467206955,
0.08365681767463684,
0.23540708422660828,
0.2944379448890686,
0.22781607508659363,
0.02947402000427246,
-0.2182389199733734,
-0.11525577306747437,
-0.08183173090219498,
0.2992880344390869,
-0.2654014229774475,
-0.18098300695419312,
-0.11381328105926514,
0.2647770345211029,
0.09903502464294434,
0.16688115894794464,
0.022270968183875084,
0.0774698480963707,
0.07062610983848572,
0.04219167307019234,
0.04697994515299797,
0.18302443623542786,
0.08407667279243469,
-0.17511533200740814,
-0.0723697617650032,
-0.03358517959713936,
0.363069087266922,
0.07988941669464111,
-0.4269840121269226,
0.20451495051383972,
0.030380772426724434,
-0.0888400748372078,
0.04759780690073967,
0.02992534264922142,
0.06623195856809616,
-0.16402965784072876,
-0.08183623105287552,
0.2549808621406555,
-0.01541075762361288,
0.07530690729618073,
0.2841997742652893,
-0.1014457419514656,
0.11125809699296951,
0.15161330997943878,
-0.24694913625717163,
-0.13085198402404785,
0.011201404966413975,
-0.14210984110832214,
0.20815709233283997,
-0.06194964423775673,
0.011277558282017708,
-0.14535653591156006,
-0.056136079132556915,
0.3055041432380676,
0.11058158427476883,
0.12377883493900299,
-0.1907581388950348,
-0.06837208569049835,
-0.26949721574783325,
0.010016526095569134,
0.34420254826545715,
-0.058308232575654984,
0.026849396526813507,
0.020775998011231422,
0.14884024858474731,
0.10741684585809708,
0.03202638775110245,
-0.05111692100763321,
-0.08624932914972305,
0.08085597306489944,
-0.17862269282341003,
0.15439961850643158,
0.0009769785683602095,
0.06082307547330856,
-0.03489093482494354,
-0.13975071907043457,
0.1050570011138916,
0.0156567245721817,
0.10319846123456955,
-0.11983011662960052,
0.11948788911104202,
0.00031671373290009797,
-0.04151485487818718,
-0.3627936542034149,
0.050077326595783234,
-0.04473242908716202,
-0.03836459666490555,
0.021642174571752548,
-0.09206078201532364,
0.06576322764158249,
-0.07081907242536545,
-0.13113227486610413,
0.0006514065898954868,
-0.09792954474687576,
-0.07237540185451508,
-0.29972484707832336,
-0.03642463684082031,
0.08848422020673752,
0.19174394011497498,
0.002941294340416789,
-0.13006283342838287,
0.1898687332868576,
-0.11055828630924225,
0.06749553978443146,
-0.2854403853416443,
-0.047615136951208115,
-0.11639466136693954,
-0.10028241574764252,
-0.34462642669677734,
0.05723857879638672,
0.3278146982192993,
-0.10079200565814972,
0.36413857340812683,
0.11396986991167068,
0.07308715581893921,
-0.11788789182901382,
0.13360844552516937,
-0.026416946202516556,
-0.2110198438167572,
-0.016477510333061218,
-0.16354092955589294,
-0.19031673669815063,
-0.11317576467990875,
0.12303034216165543,
0.350487619638443,
-0.10509013384580612,
-0.14736740291118622,
0.021387124434113503,
-0.3349933922290802,
0.06218208000063896,
-0.09937813133001328,
-0.18763074278831482,
0.3377840518951416,
-0.011357859708368778,
-0.1719972938299179,
0.18377457559108734,
-0.14350125193595886,
-0.07994528114795685,
0.10756894946098328,
-0.07510603964328766,
-0.26552581787109375,
-0.0071465373039245605,
0.011054271832108498,
-0.0960889384150505,
0.1525050550699234,
0.20028571784496307,
0.13106241822242737,
0.035775572061538696,
-0.08992080390453339,
0.14651326835155487,
-0.02081884816288948,
0.4186590909957886,
-0.1920701116323471,
-0.09173420816659927,
0.014563198201358318,
0.0019129246938973665,
0.040826257318258286,
-0.1797582358121872,
0.06942728906869888,
-0.005870204884558916,
0.11661228537559509,
-0.2271772176027298,
0.24601703882217407,
-0.2651977837085724,
0.17811274528503418,
-0.14712770283222198,
-0.024807095527648926,
-0.036802954971790314,
-0.10476449131965637,
-0.0032477248460054398,
-0.018566811457276344,
0.013088910840451717,
0.25370264053344727,
-0.08991088718175888,
-0.17906653881072998,
0.13196872174739838,
0.039800748229026794,
0.13974718749523163,
0.062486082315444946,
0.15629588067531586,
0.17250880599021912,
-0.1440589874982834,
0.4485946595668793,
-0.0285284873098135,
0.08125375956296921,
0.024900848045945168,
-0.0037517091259360313,
0.08516790717840195,
0.1285080462694168,
0.10512108355760574,
0.06992292404174805,
0.01937718316912651,
0.053928159177303314,
0.017078468576073647,
0.11090552806854248,
0.033384282141923904,
0.11247409880161285,
0.08418780565261841,
-0.09777335077524185,
-0.06441009044647217,
-0.14585241675376892,
0.18945971131324768,
-0.06872835010290146,
0.13501836359500885,
0.19136451184749603,
-0.06079568341374397,
0.032424598932266235,
0.09843984991312027,
-0.33428922295570374,
0.11809290200471878,
0.2305683195590973,
0.1317857801914215,
-0.05914004519581795,
0.043596841394901276,
0.24754469096660614,
-0.030695853754878044,
-0.04846861958503723,
0.05351686850190163,
0.11150911450386047,
0.16395732760429382,
-0.04028113931417465,
0.12048913538455963,
0.22930526733398438,
-0.014924205839633942,
0.04609262943267822,
0.016315137967467308,
0.09885034710168839,
0.09459882974624634,
-0.014568406157195568,
-0.09190914034843445,
0.31665465235710144,
-0.13605253398418427,
0.2015628218650818,
0.02262657694518566,
0.027374405413866043,
0.39141127467155457,
0.01857180707156658,
0.13842271268367767,
0.0945853665471077,
0.24203595519065857,
-0.07389875501394272,
-0.12715549767017365,
-0.05031990632414818,
0.16374653577804565,
0.13221652805805206,
0.04982324317097664,
-0.11069005727767944,
-0.019960079342126846,
-0.056814711540937424,
-0.40434423089027405,
-0.2873113751411438,
0.11423135548830032,
-0.09427661448717117,
-0.04280247911810875,
0.12171127647161484,
-0.14674320816993713,
0.16306361556053162,
-0.01683853194117546,
-0.04809584096074104,
-0.07438121736049652,
0.061004020273685455,
-0.05333961546421051,
0.039277419447898865,
-0.1421290636062622,
-0.006048750132322311,
-0.01743023470044136,
-0.025527700781822205,
-0.22997091710567474,
0.027715174481272697,
0.11164110153913498,
-0.0433105006814003,
0.10776032507419586,
-0.13051395118236542,
-0.07263069599866867,
0.1921377182006836,
0.03333105146884918,
0.09939483553171158,
-0.1511862576007843,
-0.08093816787004471,
-0.07820301502943039,
-0.007972015999257565,
0.13474082946777344,
-0.2538512051105499,
0.21649527549743652,
0.12912800908088684,
-0.10037820041179657,
0.08406926691532135,
-0.006584848742932081,
0.02763083018362522,
0.24088305234909058,
-0.02214019186794758,
0.28614234924316406,
-0.006905088201165199,
-0.006681311875581741,
-0.03222532197833061,
-0.06232349947094917,
-0.13202089071273804,
-0.04008287191390991,
0.2036224901676178,
0.17924587428569794,
-0.0039352718740701675,
0.4017377495765686,
-0.046789925545454025,
0.13819122314453125,
-0.1053944081068039,
-0.10939597338438034,
-0.013110983185470104,
0.12028858810663223,
0.32634514570236206,
-0.041557107120752335,
-0.0932396948337555,
0.07337997853755951,
-0.09123186022043228,
-0.06582190841436386,
0.21673552691936493,
-0.2773604691028595,
-0.08188702166080475,
0.002578592859208584,
-0.032072655856609344,
-0.1415719836950302,
-0.3505784869194031,
0.1788678765296936,
0.30356690287590027,
-0.20096701383590698,
-0.05540262162685394,
-0.24135909974575043,
0.07931842654943466,
0.24904201924800873,
-0.17171655595302582,
0.22513923048973083,
0.37072211503982544,
0.013671615161001682,
-0.04803715646266937,
-0.20030371844768524,
0.20489779114723206,
-0.12241583317518234,
0.09845350682735443,
-0.10671194642782211,
0.15126019716262817,
-0.06460724025964737,
0.128592386841774,
-0.06166639178991318,
0.030872629955410957,
-0.07964147627353668,
-0.20556361973285675,
-0.0917525440454483,
-0.14727874100208282,
-0.06952482461929321,
0.024325454607605934,
-0.26383426785469055,
0.22040347754955292,
-0.11397697031497955,
-0.27946698665618896,
-0.14891628921031952,
0.08295489847660065,
-0.028193023055791855,
0.18395213782787323,
-0.1831173598766327,
0.10103143006563187,
-0.01368971448391676,
0.035971369594335556,
0.07532258331775665,
0.3918551504611969,
-0.0933559387922287,
0.04726143553853035,
-0.22064204514026642,
-0.00879936758428812,
0.3111015856266022,
-0.06648571789264679,
-0.08222707360982895,
0.10472703725099564,
-0.03545084223151207,
0.11256271600723267,
-0.08767762035131454,
-0.11055106669664383,
0.057329315692186356,
-0.0030142958275973797,
0.12047351151704788,
0.11366322636604309,
-0.012958608567714691,
-0.10861147195100784,
-0.10382113605737686,
0.02407144568860531,
0.005223148502409458,
0.04999302327632904,
0.32700690627098083,
-0.21223945915699005,
0.191348597407341,
-0.13103033602237701,
-0.09224316477775574,
-0.14820311963558197,
-0.3459798991680145,
-0.11603962630033493,
0.12467998266220093,
0.19579042494297028,
0.038819875568151474,
0.19759635627269745,
-0.013188762590289116,
0.1668705940246582,
0.01939259096980095,
0.06485295295715332,
-0.0024920932482928038,
-0.22638364136219025,
-0.06807990372180939,
-0.165803462266922,
-0.07105536758899689,
0.10747724771499634,
0.12525701522827148,
-0.12457667291164398,
0.1444007009267807,
-0.17453724145889282,
-0.24342669546604156,
-0.41739970445632935,
0.0683804377913475,
0.15599723160266876,
-0.01840854249894619,
0.08403591811656952,
0.07735523581504822,
0.24602335691452026,
-0.18234297633171082,
0.10270928591489792,
0.49095019698143005,
0.07162486761808395,
-0.31607767939567566,
-0.07468909025192261,
-0.12475016713142395,
0.16327306628227234,
-0.056985724717378616,
-0.2601339817047119,
-0.01393656525760889,
0.18241862952709198,
-0.04775427281856537,
0.024956457316875458,
0.040659625083208084,
-0.06003524363040924,
-0.2533336579799652,
-0.01210588589310646,
-0.24363267421722412,
0.4588871896266937,
0.05656886845827103,
0.047850776463747025,
-0.031694695353507996,
-0.018712984398007393,
0.11028110980987549,
0.07877771556377411,
0.15205541253089905,
0.24527619779109955,
-0.1601763516664505,
0.2096116691827774,
-0.22576777637004852,
0.06829342246055603,
-0.19512704014778137,
0.08501318097114563,
-0.0030011015478521585,
-0.06962674111127853,
0.18446682393550873,
-0.00797541905194521,
0.17891822755336761,
-0.1742963343858719,
-0.04198248311877251,
-0.13981324434280396,
-0.0436050109565258,
-0.05213160440325737,
-0.02185525931417942,
0.050323374569416046,
-0.052011869847774506,
0.13264264166355133,
-0.11736457794904709,
0.10165146738290787,
-0.11799200624227524,
0.17006166279315948,
0.028495680540800095,
0.01870657131075859,
-0.1928713470697403,
-0.1939571499824524,
-0.07315149158239365,
-0.009460637345910072,
-0.0941505953669548,
0.15900444984436035,
-0.0764390230178833,
-0.1250598132610321,
-0.18969006836414337,
0.02961316891014576,
-0.029022211208939552,
0.09109622240066528,
0.08978494256734848,
0.0739797055721283,
-0.1287219524383545,
0.11734798550605774,
-0.041952796280384064,
0.005480409599840641,
-0.14465279877185822,
0.02776891365647316,
0.1201053187251091,
0.20145832002162933,
0.17628510296344757,
-0.1512191891670227,
-0.18444153666496277,
-0.16776305437088013,
-0.07064572721719742,
-0.09225118160247803,
0.24653588235378265,
-0.002490405226126313,
-0.24426433444023132,
-0.0013902847422286868,
-0.08723563700914383,
-0.14171463251113892,
0.18811792135238647,
0.07823030650615692,
0.08951709419488907
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. , abnormal growth of vertebrae)Viscera: spleen/thymusSpecific tumors with onset before the second decade (either of the following):Bilateral ovarian cystadenomaParotid monomorphic adenomaCategory CDysregulated adipose tissue (either of the following):Lipomatous overgrowthRegional lipoatrophyVascular malformations (one of the following):Capillary malformationVenous malformationLymphatic malformationBullous pulmonary degenerationFacial phenotype (all of the following):DolichocephalyLong faceDownslanting palpebral fissures and/or minor ptosisDepressed nasal bridgeWide or anteverted naresOpen mouth at restMolecular Genetic TestingApproaches can include targeted analysis, use of a multigene panel, and more comprehensive genomic testing:Targeted analysis for pathogenic variant c.49G>A (p.Glu17Lys) in the affected tissue, if possible, is | [
-0.07158396393060684,
0.03717122599482536,
-0.007847858592867851,
-0.20133909583091736,
0.14559058845043182,
0.08269398659467697,
-0.09359848499298096,
-0.09471125155687332,
-0.1108260452747345,
0.021924376487731934,
0.15838555991649628,
0.06563165783882141,
0.12449522316455841,
0.004833050537854433,
-0.18413609266281128,
0.08931565284729004,
-0.07279021292924881,
0.07570020109415054,
-0.1945413500070572,
0.04040941596031189,
0.03300098702311516,
-0.09072425961494446,
-0.039494458585977554,
0.1136712059378624,
-0.04519764706492424,
-0.22050613164901733,
0.19490079581737518,
0.12829411029815674,
-0.08528515696525574,
-0.015116303227841854,
0.042793888598680496,
-0.06142980977892876,
0.001914867083542049,
-0.33685335516929626,
0.04260292276740074,
-0.25993961095809937,
-0.08283495903015137,
-0.024325592443346977,
0.1490604728460312,
-0.16446392238140106,
-0.03820943832397461,
-0.025664791464805603,
0.020862998440861702,
-0.1501728594303131,
0.18879102170467377,
-0.1217927411198616,
0.11322647333145142,
0.09703818708658218,
0.156296044588089,
0.15589728951454163,
0.046704769134521484,
-0.10336925834417343,
0.13049101829528809,
-0.08654309809207916,
0.12404274940490723,
-0.1845478117465973,
-0.019756725057959557,
-0.11275708675384521,
-0.2776614725589752,
0.14791622757911682,
0.3427894413471222,
0.031229615211486816,
0.11429595202207565,
-0.49746236205101013,
0.04817786440253258,
-0.11308146268129349,
-0.16800269484519958,
0.06934251636266708,
0.1726752072572708,
-0.028395630419254303,
0.3238592743873596,
-0.03984158858656883,
-0.09844447672367096,
-0.18006667494773865,
-0.08904973417520523,
-0.039922650903463364,
0.09111034870147705,
-0.0835854634642601,
0.07361004501581192,
-0.20800869166851044,
-0.04005281999707222,
-0.2129870355129242,
-0.08260007202625275,
0.008919747546315193,
-0.1427716761827469,
-0.06789836287498474,
-0.10093509405851364,
-0.029763221740722656,
0.04798000305891037,
-0.04392223805189133,
0.04451780021190643,
0.008887946605682373,
0.08103743195533752,
0.07657509297132492,
0.1279923915863037,
-0.13233166933059692,
0.09873510897159576,
0.05385611206293106,
-0.07240521907806396,
0.017239265143871307,
0.016584016382694244,
0.1299380362033844,
-0.056626614183187485,
-0.0008760072523728013,
0.11412665992975235,
-0.20596006512641907,
-0.0020387102849781513,
0.02329556830227375,
0.14980199933052063,
0.058284491300582886,
-0.08516904711723328,
-0.029816359281539917,
0.1187947541475296,
-0.09708435088396072,
0.05126174911856651,
-0.09188603609800339,
0.04520685225725174,
0.0024820403195917606,
-0.16240230202674866,
0.008574483916163445,
0.08975008130073547,
-0.10965694487094879,
0.015049551613628864,
0.13228075206279755,
-0.03540981933474541,
0.003489802358672023,
0.02767314203083515,
-0.09109172224998474,
0.005265307147055864,
-0.022291194647550583,
0.021448969841003418,
-0.07952054589986801,
0.08259602636098862,
-0.2608482241630554,
0.08681503683328629,
0.04510534927248955,
-0.06532341986894608,
-0.25084424018859863,
0.03651394695043564,
0.05257469043135643,
0.2620749771595001,
0.10100416839122772,
0.38301244378089905,
0.1588471382856369,
0.08669392764568329,
-0.0006540962494909763,
0.19059550762176514,
-0.03025834821164608,
0.15873050689697266,
0.1398504227399826,
0.1860060840845108,
-0.04236894100904465,
0.17446275055408478,
0.07827548682689667,
0.037252895534038544,
-0.22523538768291473,
-0.06700392067432404,
0.16478300094604492,
-0.09826502203941345,
0.07810420542955399,
0.006513476371765137,
-0.18741954863071442,
0.02185835689306259,
-0.10571261495351791,
0.04152042418718338,
0.0929861068725586,
-0.012052632868289948,
-0.19950926303863525,
0.047927290201187134,
0.004217423964291811,
-0.3112245202064514,
0.10745318233966827,
-0.011569749563932419,
0.13947336375713348,
-0.1310417503118515,
0.03620043024420738,
0.005495741032063961,
-0.05674275755882263,
-0.11784375458955765,
-0.1290207952260971,
-0.04054492339491844,
-0.019413726404309273,
-0.13130971789360046,
-0.33641573786735535,
-0.14011359214782715,
-0.16880981624126434,
0.04343733191490173,
0.08785364031791687,
-0.18139441311359406,
0.046607062220573425,
0.09318824112415314,
-0.08992235362529755,
-0.11578474193811417,
0.049234505742788315,
0.030150510370731354,
-0.15937432646751404,
0.0075798677280545235,
-0.04746551811695099,
-0.02010752446949482,
-0.10128716379404068,
0.05869484320282936,
0.022862330079078674,
0.05551476031541824,
0.03679874539375305,
-0.01061316393315792,
0.018122030422091484,
-0.00552324065938592,
-0.15883231163024902,
-0.027954408898949623,
-0.003318055998533964,
0.15409867465496063,
0.3248296082019806,
-0.15535365045070648,
-0.07470152527093887,
-0.03839302435517311,
0.000008987278306449298,
-0.12623314559459686,
-0.11934513598680496,
-0.053668539971113205,
0.27916061878204346,
-0.1060871034860611,
0.1569172739982605,
0.0532669797539711,
-0.17884254455566406,
-0.2162618786096573,
0.14415910840034485,
-0.08997348695993423,
-0.09532149136066437,
0.09164225310087204,
0.04525815695524216,
-0.004345359746366739,
-0.015592604875564575,
-0.03150920569896698,
0.168727308511734,
0.06265139579772949,
-0.22513768076896667,
-0.12710657715797424,
0.19432754814624786,
0.05342502146959305,
0.12248086929321289,
0.07774480432271957,
-0.027460122480988503,
0.02726392075419426,
0.01065370999276638,
-0.007431757636368275,
0.06572768837213516,
0.03685494884848595,
0.1672111600637436,
-0.18499955534934998,
-0.04773486405611038,
0.043679118156433105,
-0.15265712141990662,
0.0912497267127037,
0.0616530105471611,
-0.18625514209270477,
-0.15716159343719482,
0.19236592948436737,
0.10807773470878601,
0.07590366899967194,
0.061250027269124985,
0.07673688232898712,
0.04939006268978119,
0.12672771513462067,
0.0418178029358387,
-0.19453547894954681,
0.022838279604911804,
-0.12901397049427032,
0.1849348545074463,
-0.14330144226551056,
0.02999415434896946,
-0.10593428462743759,
0.2397976517677307,
0.0016730624483898282,
0.045649342238903046,
-0.12877407670021057,
0.02461196295917034,
0.007827761583030224,
0.09162604808807373,
-0.02368217147886753,
0.2014187127351761,
-0.027093634009361267,
-0.01539398729801178,
-0.18006931245326996,
-0.021927939727902412,
0.2911558449268341,
0.15172484517097473,
-0.17854264378547668,
0.1760241538286209,
0.0615789033472538,
-0.07225380092859268,
0.05811828374862671,
0.15231093764305115,
-0.05989592894911766,
-0.09153474867343903,
-0.05196775496006012,
0.19444720447063446,
0.03655334934592247,
0.06053003668785095,
0.25062039494514465,
-0.16317124664783478,
0.04319621995091438,
0.12075433880090714,
-0.078162282705307,
-0.02856460027396679,
0.1026787981390953,
-0.06544455140829086,
0.09230659902095795,
0.03336668759584427,
0.028068775311112404,
-0.10819578915834427,
-0.10613425821065903,
0.22425873577594757,
-0.12280504405498505,
0.015455951914191246,
-0.10353841632604599,
0.06634403020143509,
-0.17908693850040436,
0.08457051217556,
0.24423016607761383,
0.06297285854816437,
0.09322959184646606,
0.0708971843123436,
0.1307760626077652,
0.24972133338451385,
0.057572368532419205,
-0.10177745670080185,
-0.15845255553722382,
0.07585056126117706,
-0.1647961437702179,
0.19667275249958038,
0.06450987607240677,
0.06925886869430542,
-0.06828669458627701,
0.002400993835180998,
0.1514776051044464,
-0.12583421170711517,
0.04479045420885086,
-0.11160977184772491,
0.03211570158600807,
-0.07664088159799576,
-0.017482588067650795,
-0.17096978425979614,
-0.061749134212732315,
-0.06444154679775238,
0.04704686626791954,
0.17263491451740265,
0.022510910406708717,
0.018623022362589836,
-0.08201532810926437,
-0.260048508644104,
-0.06810913980007172,
0.015932288020849228,
0.09027542173862457,
-0.28865712881088257,
0.14636662602424622,
-0.02140592597424984,
-0.01467615645378828,
0.046673793345689774,
0.009411592036485672,
0.18402831256389618,
-0.1366683840751648,
-0.02537979930639267,
-0.08934549242258072,
-0.1085108071565628,
-0.016680773347616196,
-0.12315014749765396,
-0.07336246967315674,
0.12640301883220673,
0.16365331411361694,
-0.0530126728117466,
0.2690314054489136,
0.17986324429512024,
-0.04734231159090996,
-0.038819123059511185,
0.06005542352795601,
-0.02192225679755211,
-0.14203661680221558,
0.031707827001810074,
-0.11052437871694565,
-0.14501936733722687,
0.0067273639142513275,
-0.020905908197164536,
0.3557732403278351,
-0.1556800752878189,
-0.05715887248516083,
0.1246781274676323,
-0.18743565678596497,
0.04187608137726784,
-0.020380033180117607,
-0.15077529847621918,
0.2282072752714157,
0.022755512967705727,
-0.0766904354095459,
0.0004695452516898513,
-0.1386699229478836,
-0.04270268231630325,
0.19533482193946838,
-0.01571490988135338,
-0.1677507609128952,
-0.19044338166713715,
-0.13400724530220032,
-0.15592974424362183,
-0.09155122935771942,
0.1556807905435562,
0.08042841404676437,
0.009835534729063511,
-0.08190977573394775,
0.21966339647769928,
-0.05863640084862709,
0.35440191626548767,
-0.007258450146764517,
0.013914794661104679,
-0.07855008542537689,
0.042657520622015,
-0.07745171338319778,
-0.10603711754083633,
-0.06757212430238724,
-0.07937949895858765,
-0.04947447031736374,
-0.13834071159362793,
0.013011040166020393,
0.03591340407729149,
0.10760565102100372,
-0.16289351880550385,
-0.06293442845344543,
-0.027260931208729744,
-0.037703316658735275,
0.10934067517518997,
0.10852470993995667,
0.08381135761737823,
0.22881685197353363,
-0.06970418989658356,
-0.15583446621894836,
0.1258036196231842,
-0.03065008856356144,
0.3138454258441925,
0.006510434206575155,
0.052136823534965515,
0.3053579032421112,
-0.12369279563426971,
0.3061547577381134,
-0.0357634611427784,
0.11172174662351608,
-0.009524635970592499,
-0.048791348934173584,
0.07429957389831543,
0.08859989047050476,
0.030900487676262856,
0.0662977546453476,
0.12256821990013123,
-0.038821544498205185,
0.04209769889712334,
0.07042299211025238,
0.03269815817475319,
0.07647529989480972,
0.12317553162574768,
-0.09516800940036774,
-0.014710585586726665,
-0.13779249787330627,
0.05424455553293228,
-0.11693394929170609,
0.10760990530252457,
0.20964235067367554,
-0.07757941633462906,
0.08538157492876053,
-0.009117943234741688,
-0.12974166870117188,
0.00146024813875556,
0.16643685102462769,
0.1598130613565445,
0.04381110146641731,
-0.0033643683418631554,
-0.056478578597307205,
0.12714530527591705,
-0.12739087641239166,
-0.04979466274380684,
0.019909238442778587,
0.06816107779741287,
0.0056747980415821075,
0.061651162803173065,
0.1600026786327362,
-0.06742849946022034,
0.03310795873403549,
-0.07059191167354584,
0.02694208174943924,
0.033951111137866974,
0.0267952773720026,
-0.016524000093340874,
0.16053195297718048,
-0.061503294855356216,
0.11816828697919846,
0.08306507021188736,
0.15706147253513336,
0.38185450434684753,
-0.08014897257089615,
0.01655426062643528,
0.08505622297525406,
0.11888691782951355,
-0.21150551736354828,
-0.06527122110128403,
0.047053366899490356,
0.09455061703920364,
0.08775188773870468,
0.008515330031514168,
-0.19450408220291138,
-0.11379162967205048,
-0.025445936247706413,
-0.21311601996421814,
-0.20471066236495972,
0.016736546531319618,
-0.05813891440629959,
0.0009570805705152452,
0.06759896129369736,
-0.10884302854537964,
0.0913364589214325,
-0.021748198196291924,
-0.027736946940422058,
-0.13287730515003204,
0.06163229048252106,
-0.12218417972326279,
0.0024438800755888224,
-0.24453815817832947,
-0.027149906381964684,
-0.07157176733016968,
-0.038563184440135956,
-0.221297025680542,
0.015166950412094593,
0.11787381768226624,
0.010700090788304806,
-0.050981927663087845,
-0.1774926781654358,
-0.02546757645905018,
-0.030527528375387192,
0.010937642306089401,
0.1163850873708725,
-0.08487562090158463,
0.08121398091316223,
-0.017245814204216003,
-0.14670245349407196,
-0.06105680391192436,
-0.19730283319950104,
0.11830585449934006,
0.08739419281482697,
-0.09966352581977844,
0.21225044131278992,
0.07387228310108185,
0.09529179334640503,
0.1458681970834732,
0.059769898653030396,
0.2008214145898819,
0.03536556288599968,
-0.11878987401723862,
-0.04790562018752098,
-0.04831261187791824,
-0.1071941927075386,
-0.009325220249593258,
0.1358746588230133,
0.11055861413478851,
-0.07088320702314377,
0.2942359745502472,
-0.041113462299108505,
0.054227642714977264,
-0.07336955517530441,
-0.034305304288864136,
0.047920387238264084,
0.07930736988782883,
0.3045559525489807,
-0.12794634699821472,
0.053609829396009445,
0.04900321736931801,
-0.1818765252828598,
0.01191188208758831,
0.16567879915237427,
-0.1644343137741089,
-0.03174138069152832,
0.009341338649392128,
-0.046911776065826416,
-0.06561929732561111,
-0.19820381700992584,
0.1579214632511139,
0.033606868237257004,
-0.15159375965595245,
-0.16842421889305115,
-0.24479009211063385,
0.19165758788585663,
0.19396387040615082,
-0.16852381825447083,
0.15310172736644745,
0.256964772939682,
-0.01978323794901371,
-0.03637070208787918,
-0.09925048053264618,
0.09199752658605576,
0.0257466621696949,
0.052496664226055145,
-0.017240408807992935,
0.04300956428050995,
-0.012414058670401573,
0.07024714350700378,
-0.11604387313127518,
-0.06251469999551773,
0.09371640533208847,
-0.20767797529697418,
-0.07137357443571091,
-0.029153985902667046,
-0.03884933888912201,
0.06268930435180664,
-0.3017801344394684,
0.22392667829990387,
-0.11900121718645096,
-0.21268770098686218,
-0.10465190559625626,
0.05034608766436577,
-0.04194273054599762,
0.1726672500371933,
-0.07917332649230957,
0.029473964124917984,
0.02253483422100544,
0.21829888224601746,
0.0016038620378822088,
0.27683162689208984,
-0.011475359089672565,
0.13149826228618622,
-0.19171856343746185,
0.04722028225660324,
0.22817671298980713,
-0.04131796956062317,
-0.0174099113792181,
0.11176219582557678,
0.04077407345175743,
0.0828271210193634,
-0.10100185126066208,
-0.19054964184761047,
0.05430931597948074,
-0.13574038445949554,
0.11401409655809402,
-0.04640614986419678,
-0.12781521677970886,
-0.07653075456619263,
-0.11284586787223816,
0.05531095713376999,
0.10476300120353699,
0.06516417115926743,
0.13954979181289673,
-0.22499233484268188,
0.053028568625450134,
-0.014658475294709206,
-0.08718769252300262,
-0.14538346230983734,
-0.1979125291109085,
-0.01726626046001911,
0.13946892321109772,
0.11463213711977005,
0.10213737934827805,
0.1591029167175293,
-0.11337730288505554,
0.18237553536891937,
0.026125194504857063,
0.024981945753097534,
-0.05885245278477669,
-0.12536939978599548,
0.010861402377486229,
-0.14442798495292664,
-0.033538129180669785,
0.058560535311698914,
0.03562407195568085,
-0.09892265498638153,
0.1932544708251953,
-0.1878363937139511,
-0.07122617959976196,
-0.40839043259620667,
0.033704038709402084,
0.18539537489414215,
0.01698981411755085,
0.02839968167245388,
0.10422461479902267,
0.18300993740558624,
-0.06170647218823433,
-0.048237744718790054,
0.322645902633667,
0.05352092534303665,
-0.3542971909046173,
-0.07282394170761108,
-0.12983132898807526,
0.026073945686221123,
0.03009713999927044,
-0.18125301599502563,
0.00038849664269946516,
0.21836979687213898,
0.019706763327121735,
-0.08142177760601044,
-0.14579781889915466,
0.016531314700841904,
-0.02781735546886921,
-0.16165344417095184,
-0.09450391680002213,
0.25990918278694153,
0.09828490018844604,
0.11926005780696869,
-0.06602107733488083,
-0.00925412680953741,
-0.01697285659611225,
-0.026654228568077087,
0.045867085456848145,
0.0853007510304451,
-0.08621753752231598,
0.17303858697414398,
-0.10318020731210709,
0.11525274813175201,
-0.12749771773815155,
-0.14929284155368805,
-0.12014710903167725,
0.19366806745529175,
0.15614554286003113,
-0.05978608876466751,
0.09703896194696426,
-0.09063895791769028,
0.1475164145231247,
-0.1212359294295311,
-0.03923536464571953,
-0.051984112709760666,
0.11080177873373032,
-0.08013251423835754,
-0.00551962573081255,
0.1072792187333107,
-0.037467096000909805,
0.12319619208574295,
-0.038016270846128464,
0.15508905053138733,
0.19519223272800446,
0.042343053966760635,
-0.16407817602157593,
-0.2419508695602417,
-0.01638166420161724,
-0.08679813891649246,
0.03198430687189102,
0.08202451467514038,
-0.09773419052362442,
0.043570298701524734,
-0.21367545425891876,
0.009729468263685703,
-0.055760785937309265,
-0.013559270650148392,
0.008947025053203106,
0.16785813868045807,
-0.07256534695625305,
0.07137208431959152,
-0.031086424365639687,
-0.10420499742031097,
-0.03469211980700493,
0.05173235386610031,
0.06509808450937271,
0.2093515843153,
0.06926009804010391,
0.0452125146985054,
-0.14031147956848145,
-0.10699700564146042,
-0.16026921570301056,
-0.10977618396282196,
0.02348395064473152,
-0.001562065095640719,
0.009246005676686764,
0.15892696380615234,
0.06647644937038422,
-0.2253124713897705,
0.1639874428510666,
0.06167441979050636,
-0.006914879195392132
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. of the following):DolichocephalyLong faceDownslanting palpebral fissures and/or minor ptosisDepressed nasal bridgeWide or anteverted naresOpen mouth at restMolecular Genetic TestingApproaches can include targeted analysis, use of a multigene panel, and more comprehensive genomic testing:Targeted analysis for pathogenic variant c.49G>A (p.Glu17Lys) in the affected tissue, if possible, is performed first.Note: (1) Although a single AKT1 variant has been reported, it is possible that other variants in this gene detectable by sequence analysis could be causative of disease. (2) Because all AKT1 c.49G>A pathogenic variants reported to date are somatic and mosaic, more than one tissue sample may be required for diagnosis. Identification of an AKT1 pathogenic variant requires analysis of affected tissues, typically a punch biopsy of an affected area | [
0.029694804921746254,
-0.01476901676505804,
-0.10744232684373856,
-0.3367518484592438,
0.18122966587543488,
0.03140972554683685,
-0.025427957996726036,
-0.21897834539413452,
-0.04936981946229935,
0.05610375478863716,
0.15983116626739502,
-0.044858984649181366,
0.07297849655151367,
-0.008214927278459072,
-0.24654443562030792,
0.18127979338169098,
-0.03056250512599945,
0.2266799956560135,
-0.03748476132750511,
0.10215669125318527,
0.08454132080078125,
-0.11069491505622864,
0.1280159205198288,
0.10819438099861145,
-0.06005566194653511,
-0.4010290503501892,
0.33712857961654663,
0.09372515231370926,
-0.189421609044075,
-0.08789962530136108,
-0.010057371109724045,
0.06565409153699875,
-0.12148807942867279,
-0.20039302110671997,
-0.0607244037091732,
-0.3574528992176056,
-0.08772557228803635,
-0.017238641157746315,
0.1580917239189148,
-0.024729739874601364,
0.07569725066423416,
-0.016105785965919495,
0.16666467487812042,
-0.2040543556213379,
0.2026507556438446,
-0.21771039068698883,
0.1238870769739151,
0.037498265504837036,
0.1584756076335907,
0.11171142011880875,
-0.01769348978996277,
0.03366123139858246,
0.13648489117622375,
-0.04864604026079178,
0.1552165001630783,
-0.10940442979335785,
0.004108370281755924,
-0.2245187759399414,
-0.29835960268974304,
0.02163608931005001,
0.18442337214946747,
-0.049651097506284714,
-0.02630595862865448,
-0.35933640599250793,
0.10966046899557114,
-0.22136478126049042,
-0.12153729796409607,
0.1345987319946289,
0.20713813602924347,
0.012515373528003693,
0.1773727387189865,
-0.050413161516189575,
0.1480744183063507,
-0.20372356474399567,
0.028958814218640327,
-0.04639600217342377,
0.16722875833511353,
-0.014873113483190536,
0.06007308512926102,
-0.17720536887645721,
-0.19393332302570343,
-0.19750496745109558,
-0.11729509383440018,
0.18679334223270416,
-0.13193213939666748,
-0.18161852657794952,
-0.10956744849681854,
-0.16503900289535522,
-0.0161135271191597,
0.05585163086652756,
0.07555629312992096,
0.1119772344827652,
0.13863033056259155,
0.2648044526576996,
0.11388801038265228,
-0.03908699005842209,
0.12941861152648926,
0.054671257734298706,
-0.17960532009601593,
0.017021939158439636,
0.04940158128738403,
0.17115336656570435,
-0.20749200880527496,
0.10118618607521057,
0.07168932259082794,
-0.12170488387346268,
-0.057462096214294434,
-0.0076695154421031475,
-0.013622259721159935,
0.002423043129965663,
-0.10570491850376129,
-0.06652025878429413,
-0.017537424340844154,
-0.027969904243946075,
-0.01442965492606163,
-0.11371748149394989,
-0.0769011601805687,
-0.010430299676954746,
-0.19915084540843964,
0.1360095739364624,
0.11147791147232056,
-0.13828358054161072,
-0.05695406720042229,
0.12686026096343994,
-0.06105858460068703,
-0.0212874636054039,
0.17016443610191345,
-0.1977144032716751,
0.19689537584781647,
-0.03729121387004852,
0.05748807266354561,
-0.021133005619049072,
0.08872834593057632,
-0.0912061259150505,
0.1722487509250641,
-0.10071907192468643,
-0.1214013397693634,
-0.15667782723903656,
-0.045325957238674164,
0.06884489953517914,
0.2519419193267822,
0.16581521928310394,
0.3762208819389343,
0.11243027448654175,
0.07256956398487091,
0.04346415773034096,
0.28504595160484314,
-0.1454959511756897,
0.05398695170879364,
-0.014770322479307652,
0.08020183444023132,
0.005227500572800636,
0.28607773780822754,
0.021059609949588776,
-0.10329001396894455,
-0.10557122528553009,
-0.10169170796871185,
0.24113662540912628,
-0.20357610285282135,
0.06978202611207962,
0.05600123852491379,
-0.18645189702510834,
0.04540888965129852,
-0.11419371515512466,
0.19359715282917023,
0.16212014853954315,
0.04811493307352066,
-0.16156744956970215,
0.24147674441337585,
0.08900471031665802,
-0.15501590073108673,
0.15398189425468445,
-0.002019077306613326,
0.12604860961437225,
-0.011854046024382114,
0.04821044206619263,
-0.06769634783267975,
-0.011285032145678997,
-0.04827279970049858,
-0.14753250777721405,
-0.05463912710547447,
-0.004356620367616415,
-0.15209057927131653,
-0.17629048228263855,
-0.09901684522628784,
-0.12759636342525482,
0.03662066534161568,
0.1663135141134262,
-0.11965424567461014,
0.1547260284423828,
0.049219902604818344,
-0.04847992956638336,
-0.16264230012893677,
-0.09462539851665497,
0.08381851017475128,
-0.26175564527511597,
-0.01835530623793602,
0.022368676960468292,
0.10600092262029648,
-0.12034942209720612,
-0.012673454359173775,
-0.0002002120454562828,
-0.13610772788524628,
-0.0013100445503368974,
0.051949337124824524,
0.1589546799659729,
-0.07622920721769333,
-0.11994942277669907,
0.029446177184581757,
0.0335952453315258,
0.10202021896839142,
0.37639811635017395,
-0.11267036944627762,
0.032481081783771515,
0.0071837459690868855,
-0.01717902533710003,
-0.10030539333820343,
-0.24927304685115814,
0.04063579440116882,
0.2941948175430298,
-0.11384541541337967,
0.21583124995231628,
0.021101081743836403,
-0.22235877811908722,
-0.22498652338981628,
0.1922631859779358,
-0.14809440076351166,
-0.06040972098708153,
0.050722189247608185,
0.06460678577423096,
0.013870986178517342,
-0.0877402126789093,
-0.07273470610380173,
0.038356710225343704,
-0.04010917618870735,
-0.1507563292980194,
-0.01741904951632023,
0.19561146199703217,
-0.025028282776474953,
0.011589176021516323,
0.027770569548010826,
-0.07796666026115417,
0.0567617267370224,
-0.054248642176389694,
0.014394205063581467,
0.12878429889678955,
-0.021857719868421555,
0.18480947613716125,
-0.3770006597042084,
-0.10689441859722137,
-0.04443926736712456,
-0.16701124608516693,
0.16957764327526093,
0.04741881787776947,
-0.20823748409748077,
-0.25702568888664246,
-0.0159574206918478,
0.03494987264275551,
0.16969187557697296,
0.02169441245496273,
0.10517175495624542,
0.0587574802339077,
0.09049756824970245,
0.10498452186584473,
-0.2441125065088272,
-0.15040971338748932,
-0.1211085394024849,
0.12108971923589706,
-0.20538528263568878,
-0.039261482656002045,
-0.13766364753246307,
0.1530003696680069,
-0.18534934520721436,
0.021626221016049385,
-0.1633099615573883,
0.013278038240969181,
0.14869695901870728,
0.11491518467664719,
0.023271724581718445,
0.15985950827598572,
-0.11579307913780212,
0.01826271042227745,
-0.07536574453115463,
0.11254628747701645,
0.27024227380752563,
0.0011011523893103004,
-0.23305177688598633,
0.07256443798542023,
0.06919029355049133,
0.014556003734469414,
0.01433518435806036,
0.18724216520786285,
-0.019857216626405716,
0.07818672806024551,
0.029264530166983604,
0.11910340934991837,
0.0006928044022060931,
-0.11508707702159882,
0.1778329312801361,
-0.15153934061527252,
0.24432896077632904,
0.21222536265850067,
0.02478121407330036,
-0.10021433234214783,
0.036580052226781845,
0.08754021674394608,
0.1749456226825714,
-0.09526828676462173,
0.06948406249284744,
-0.14620159566402435,
-0.2568093538284302,
0.15690308809280396,
-0.13268156349658966,
0.023159699514508247,
-0.14048418402671814,
0.1545603722333908,
0.06204342469573021,
-0.029802432283759117,
0.18064646422863007,
0.1338515728712082,
-0.1160547211766243,
0.12161991000175476,
0.14362832903862,
0.16635969281196594,
0.05147109553217888,
-0.08863087743520737,
-0.14294768869876862,
0.15099333226680756,
-0.10946130007505417,
0.14836543798446655,
0.14657403528690338,
0.03577931597828865,
-0.11345022916793823,
0.08861538022756577,
0.0946444645524025,
-0.013058754615485668,
0.018702400848269463,
-0.042581621557474136,
-0.11480528861284256,
-0.07840190082788467,
-0.0162904541939497,
-0.11786478012800217,
0.001060609007254243,
0.08488665521144867,
0.021126722916960716,
0.2502553462982178,
0.012033163569867611,
0.0739373192191124,
-0.101198710501194,
-0.12794576585292816,
-0.06318558752536774,
-0.032996855676174164,
0.03458598256111145,
-0.2286948412656784,
0.29406410455703735,
-0.0820222869515419,
0.11960004270076752,
0.01938057318329811,
-0.016207383945584297,
0.15263311564922333,
-0.08595038205385208,
-0.06006859987974167,
-0.10970460623502731,
-0.12842392921447754,
-0.00020735700672958046,
-0.024818044155836105,
-0.0505358949303627,
0.2520759403705597,
0.11948797106742859,
0.04726434871554375,
0.2312845140695572,
0.15942052006721497,
0.0757187083363533,
-0.04528362303972244,
-0.007978703826665878,
0.010410038754343987,
-0.18445704877376556,
0.13266095519065857,
-0.013950838707387447,
-0.14283423125743866,
0.16627052426338196,
0.11806349456310272,
0.1523684710264206,
-0.19109469652175903,
0.006350092589855194,
0.11259199678897858,
-0.19573481380939484,
0.04836711287498474,
0.0759715661406517,
-0.011093128472566605,
0.12807108461856842,
0.050957851111888885,
0.05378952994942665,
-0.05079292133450508,
-0.1003279834985733,
-0.09435221552848816,
0.19836997985839844,
-0.14679227769374847,
-0.2062661498785019,
-0.1683972179889679,
-0.1910981386899948,
-0.1305946260690689,
-0.10208433121442795,
0.14720825850963593,
-0.06290300190448761,
0.04215472191572189,
0.03183276578783989,
0.17395523190498352,
-0.0823691189289093,
0.4099036753177643,
-0.04241827130317688,
-0.07548870146274567,
-0.1769610494375229,
-0.050090283155441284,
-0.06643752008676529,
-0.1336885541677475,
0.10605063289403915,
0.11132758110761642,
-0.008454597555100918,
-0.10963054746389389,
0.12777405977249146,
0.394548624753952,
0.03576592355966568,
-0.21232439577579498,
-0.08145447820425034,
-0.09511499106884003,
-0.11237223446369171,
0.09320227801799774,
0.13542090356349945,
0.12591905891895294,
0.07713005691766739,
-0.03313560411334038,
-0.14822202920913696,
0.017531495541334152,
-0.04641906917095184,
0.1887393444776535,
0.23782563209533691,
-0.020692430436611176,
0.19969715178012848,
-0.16539481282234192,
0.21758216619491577,
0.03539352864027023,
0.08494127541780472,
0.10454753786325455,
-0.06094607710838318,
-0.00930002611130476,
0.013958506286144257,
0.04132963716983795,
0.035326551645994186,
0.03105410560965538,
-0.054596975445747375,
0.010435941629111767,
0.10601650178432465,
-0.027319185435771942,
0.08349628001451492,
0.11174991726875305,
-0.060582321137189865,
-0.034747250378131866,
-0.08901293575763702,
-0.03512359783053398,
-0.1653285026550293,
0.06899385899305344,
0.20941726863384247,
-0.008837457746267319,
0.07700721174478531,
-0.02565903216600418,
-0.029857264831662178,
0.0646766647696495,
0.118244968354702,
0.0974205881357193,
0.06860246509313583,
-0.021388757973909378,
0.04297417774796486,
0.004921625833958387,
-0.09918662905693054,
-0.12671427428722382,
0.031144652515649796,
0.01089506596326828,
-0.12318574637174606,
-0.053604837507009506,
0.1769123375415802,
0.018546272069215775,
-0.021914977580308914,
-0.016506141051650047,
0.04034952446818352,
0.16181311011314392,
0.09689011424779892,
-0.16106297075748444,
0.20761117339134216,
-0.2066645622253418,
0.03846556320786476,
0.02150217816233635,
0.14709198474884033,
0.28728872537612915,
-0.21788561344146729,
-0.10581471025943756,
0.13618965446949005,
0.0284601878374815,
-0.1832246035337448,
-0.08796755224466324,
0.04282517358660698,
0.2658325135707855,
0.036107033491134644,
0.07096676528453827,
-0.1942710280418396,
-0.09897308796644211,
0.053498439490795135,
-0.34070253372192383,
-0.15328025817871094,
0.034474872052669525,
-0.16662615537643433,
-0.052779052406549454,
0.21572671830654144,
-0.18676495552062988,
0.22824330627918243,
-0.11572142690420151,
-0.06140892580151558,
-0.058742716908454895,
0.06280055642127991,
-0.05344695225358009,
-0.010443097911775112,
-0.22491498291492462,
0.020812328904867172,
0.08280187100172043,
-0.07192465662956238,
-0.2654675245285034,
0.00607346324250102,
0.1231168583035469,
-0.06466551125049591,
0.18484371900558472,
-0.21702373027801514,
0.027536246925592422,
-0.15695281326770782,
0.07268933206796646,
0.06653452664613724,
-0.0497807152569294,
0.1152052953839302,
-0.0032901738304644823,
-0.15282051265239716,
-0.05554037541151047,
-0.22628246247768402,
-0.015779759734869003,
0.07885660231113434,
0.012172172777354717,
0.15052127838134766,
-0.0277028139680624,
0.06815328449010849,
0.18482616543769836,
0.26974228024482727,
0.14511574804782867,
-0.07056480646133423,
-0.16491258144378662,
-0.015245035290718079,
-0.043794821947813034,
-0.27027538418769836,
0.025647150352597237,
0.0539306178689003,
0.036806728690862656,
-0.12525391578674316,
0.30680951476097107,
0.10341966897249222,
0.0015234311576932669,
-0.043830063194036484,
-0.051905546337366104,
0.14941047132015228,
0.3229565918445587,
0.12125599384307861,
-0.13192644715309143,
0.10552079975605011,
-0.02265995182096958,
-0.19257752597332,
-0.04449082165956497,
0.3029998540878296,
-0.08770067244768143,
-0.1314154863357544,
-0.11207742989063263,
-0.10709653794765472,
-0.13932019472122192,
-0.15538270771503448,
0.07697205990552902,
0.10682078450918198,
-0.11557666957378387,
-0.11589477956295013,
-0.3207798898220062,
0.14364609122276306,
0.13496358692646027,
-0.1253768503665924,
0.08416061103343964,
0.356738418340683,
0.00953505840152502,
-0.009068513289093971,
-0.12150173634290695,
0.19312143325805664,
0.04438247159123421,
0.013421976938843727,
0.08648447692394257,
0.17795142531394958,
0.03257571905851364,
0.04294315353035927,
-0.16638685762882233,
-0.04918573424220085,
0.1715220808982849,
-0.1868596225976944,
-0.06296193599700928,
0.12448348104953766,
0.04792700335383415,
0.011163054034113884,
-0.19273026287555695,
0.21302857995033264,
-0.021768486127257347,
-0.2520502507686615,
-0.14267344772815704,
-0.01797906681895256,
0.031131194904446602,
0.23369628190994263,
-0.11451157182455063,
0.11580947041511536,
0.1360998898744583,
0.33535832166671753,
-0.016940059140324593,
0.3339281380176544,
-0.06072363257408142,
0.11167321354150772,
-0.27446693181991577,
-0.034070637077093124,
0.251041442155838,
-0.097055584192276,
-0.014516154304146767,
0.1834249645471573,
-0.10787634551525116,
-0.04090356081724167,
-0.188442662358284,
-0.08484314382076263,
0.14666733145713806,
-0.027598077431321144,
0.1596745252609253,
-0.06890552490949631,
-0.32713842391967773,
-0.10562672466039658,
-0.09212604910135269,
0.0800691470503807,
0.0770544782280922,
0.024712661281228065,
-0.03784129396080971,
-0.27343663573265076,
0.010503026656806469,
0.08263827115297318,
-0.08152146637439728,
-0.07567379623651505,
-0.07951240241527557,
-0.04663167521357536,
0.23476262390613556,
-0.0951526090502739,
0.1580769121646881,
0.20265908539295197,
-0.08584406971931458,
0.1669396013021469,
0.07531202584505081,
-0.00671758595854044,
-0.04685811698436737,
-0.08650922030210495,
-0.06854677200317383,
-0.008101842366158962,
-0.11138564348220825,
0.17587816715240479,
-0.004805165342986584,
-0.08327360451221466,
0.18631072342395782,
-0.13488435745239258,
-0.07096900045871735,
-0.32919633388519287,
0.03587106615304947,
0.10202398896217346,
-0.01786794513463974,
0.10533774644136429,
0.10247113555669785,
0.06659726798534393,
-0.08457568287849426,
-0.04987649619579315,
0.34805694222450256,
-0.042714137583971024,
-0.47110286355018616,
-0.061511263251304626,
-0.08524638414382935,
0.09620009362697601,
0.0325399674475193,
-0.12210363894701004,
0.06257208436727524,
0.08849633485078812,
-0.03352176398038864,
-0.20390741527080536,
-0.1475786417722702,
-0.029851878061890602,
0.04484490677714348,
-0.1070626974105835,
-0.058194659650325775,
0.3976300358772278,
0.06082538515329361,
-0.01551155373454094,
-0.13343439996242523,
0.03089703992009163,
-0.003632666077464819,
0.01849086582660675,
0.04192737489938736,
0.11402632296085358,
-0.16406069695949554,
0.23200389742851257,
-0.22889524698257446,
-0.004145197570323944,
-0.13731995224952698,
-0.0639902800321579,
-0.26392248272895813,
0.1259976476430893,
0.13993410766124725,
-0.14302192628383636,
0.09595809876918793,
-0.11303351819515228,
0.20322991907596588,
-0.08289045840501785,
0.08966551721096039,
0.004048128612339497,
0.02399749867618084,
0.14307382702827454,
-0.10739326477050781,
0.1946270614862442,
-0.027420997619628906,
0.11306878924369812,
0.13714195787906647,
0.12764328718185425,
0.14950460195541382,
0.002885161666199565,
-0.10348939150571823,
-0.17693227529525757,
0.09339363873004913,
0.06602776795625687,
0.05538812652230263,
0.06927134841680527,
-0.12823066115379333,
-0.035281240940093994,
-0.16966713964939117,
0.1948656141757965,
0.013262603431940079,
-0.1371924877166748,
-0.04658885300159454,
0.08137242496013641,
0.04668613150715828,
0.023008624091744423,
-0.20994418859481812,
-0.07739752531051636,
0.05631722882390022,
0.17761655151844025,
0.15804700553417206,
0.05072812736034393,
-0.0749497264623642,
0.14178724586963654,
-0.2955007553100586,
-0.14270009100437164,
-0.10940825194120407,
-0.06331972777843475,
-0.0005196609999984503,
0.01006774790585041,
-0.0448119156062603,
0.023746833205223083,
0.08258363604545593,
-0.0969771072268486,
0.1255105435848236,
-0.08408822119235992,
0.14230544865131378
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. , if possible, is performed first.Note: (1) Although a single AKT1 variant has been reported, it is possible that other variants in this gene detectable by sequence analysis could be causative of disease. (2) Because all AKT1 c.49G>A pathogenic variants reported to date are somatic and mosaic, more than one tissue sample may be required for diagnosis. Identification of an AKT1 pathogenic variant requires analysis of affected tissues, typically a punch biopsy of an affected area of skin. (3) A minority of affected individuals (2/31 reported by Lindhurst et al ) with the AKT1 c.49G>A pathogenic variant identified in one or more tissues had the pathogenic variant identified in a peripheral blood sample. Therefore, the absence of a pathogenic variant in a peripheral blood sample is not sufficient to exclude the diagnosis.A multigene panel that includes AKT1 and other genes of interest (see Differential Diagnosis) may | [
-0.030236922204494476,
-0.01211407408118248,
-0.09014357626438141,
-0.23752927780151367,
0.12297223508358002,
-0.03085653856396675,
0.08322235196828842,
-0.12417285889387131,
-0.01394443865865469,
0.03443131968379021,
0.22135549783706665,
0.010934567078948021,
-0.03931427747011185,
-0.08792272955179214,
-0.229813814163208,
0.19847236573696136,
-0.053208500146865845,
0.09370378404855728,
0.0019394803093746305,
0.17845256626605988,
0.13763974606990814,
-0.23178282380104065,
0.1298842430114746,
0.037290818989276886,
0.04631168395280838,
-0.3314458429813385,
0.23588527739048004,
0.19150756299495697,
-0.14519795775413513,
-0.023248838260769844,
-0.056098368018865585,
0.05774620920419693,
-0.035210177302360535,
-0.13005183637142181,
-0.17373350262641907,
-0.22997841238975525,
-0.1355418562889099,
0.11058911681175232,
0.10171826928853989,
0.03641803190112114,
0.13075383007526398,
0.02715775929391384,
0.12064319103956223,
-0.1362832933664322,
0.1711737960577011,
-0.17103272676467896,
0.015960851684212685,
0.02119520492851734,
0.057647597044706345,
0.11595923453569412,
0.013484606519341469,
0.07302368432283401,
0.0966748520731926,
-0.03786997124552727,
0.11499112844467163,
-0.05555783212184906,
0.04480426758527756,
-0.22185979783535004,
-0.26944831013679504,
-0.02164430543780327,
0.1496233493089676,
-0.052494265139102936,
-0.0932217687368393,
-0.179784893989563,
0.08536463975906372,
-0.09319927543401718,
-0.03100099228322506,
0.10601300746202469,
0.1897880882024765,
0.1018134132027626,
0.1802782416343689,
-0.013899999670684338,
0.15131491422653198,
-0.10391569882631302,
0.0976317971944809,
-0.00993640162050724,
0.14703206717967987,
-0.1486617624759674,
0.017342375591397285,
-0.23621618747711182,
-0.1279534101486206,
-0.12637262046337128,
0.04202878475189209,
0.20089596509933472,
-0.0557483471930027,
-0.21716992557048798,
-0.07888048887252808,
-0.08111655712127686,
-0.0801839828491211,
0.20752324163913727,
-0.0376470573246479,
0.1066579818725586,
0.11454597860574722,
0.27510640025138855,
0.13242976367473602,
0.041544076055288315,
0.09708663821220398,
0.09098071604967117,
-0.15361060202121735,
0.03951089084148407,
0.17290648818016052,
0.11292236298322678,
-0.16119921207427979,
-0.010053880512714386,
0.12905751168727875,
-0.02545972354710102,
0.013117142021656036,
-0.008562696166336536,
0.04218222200870514,
0.026719072833657265,
-0.040472034364938736,
-0.03143104910850525,
-0.1446182131767273,
-0.03809116408228874,
-0.06522670388221741,
-0.15548722445964813,
-0.10446784645318985,
0.10537206381559372,
-0.15324218571186066,
-0.020909257233142853,
0.08794376254081726,
-0.08561921119689941,
-0.06933878362178802,
-0.09327900409698486,
-0.13636519014835358,
-0.06081229820847511,
0.21604672074317932,
-0.1854570060968399,
0.11113040894269943,
0.03435462340712547,
0.08199071139097214,
-0.005044662393629551,
-0.001020693453028798,
0.005808653775602579,
0.14334937930107117,
-0.09343042969703674,
-0.15127506852149963,
-0.122625432908535,
-0.02134845405817032,
0.022868948057293892,
0.2000708132982254,
0.14526323974132538,
0.321169376373291,
0.11707885563373566,
-0.10017860680818558,
0.11660639941692352,
0.2858729064464569,
-0.1566847562789917,
0.03849480673670769,
-0.10274670273065567,
0.015044765546917915,
-0.07204710692167282,
0.29971566796302795,
0.021286899223923683,
-0.09577783942222595,
0.005750637501478195,
-0.03255588933825493,
0.25491008162498474,
-0.20469793677330017,
-0.010744472965598106,
0.009380495175719261,
-0.07339996844530106,
0.02638554945588112,
-0.042896173894405365,
0.18639987707138062,
0.15217697620391846,
0.03560085967183113,
-0.2546388506889343,
0.22493252158164978,
0.0920950397849083,
0.011476767249405384,
0.12389557808637619,
-0.03261522948741913,
0.09599553793668747,
0.033756278455257416,
-0.0128713920712471,
0.04366510361433029,
0.10634233057498932,
0.017054647207260132,
0.014112409204244614,
0.029260609298944473,
-0.04750458896160126,
-0.0351259671151638,
-0.020019687712192535,
-0.0630049854516983,
-0.06318668276071548,
0.02390490286052227,
0.10612799227237701,
-0.11290910840034485,
0.1124630719423294,
-0.056511636823415756,
-0.023630980402231216,
-0.03249819204211235,
-0.148372620344162,
0.13851270079612732,
-0.247454434633255,
-0.12031228840351105,
0.022760361433029175,
0.12806090712547302,
-0.16355104744434357,
-0.005134290549904108,
0.02079109102487564,
-0.06070255860686302,
-0.015549608506262302,
0.052337948232889175,
0.10397250950336456,
0.008401969447731972,
-0.09868751466274261,
0.06317956745624542,
0.14105954766273499,
0.14781925082206726,
0.30386418104171753,
-0.07750886678695679,
0.0027425407897681,
0.054291028529405594,
-0.04276508092880249,
-0.0739573985338211,
-0.14937140047550201,
0.012317521497607231,
0.28766417503356934,
-0.16911783814430237,
0.29165711998939514,
0.0885583832859993,
-0.19875973463058472,
-0.2864716947078705,
0.13095544278621674,
-0.06877002865076065,
-0.00888721365481615,
0.019398506730794907,
0.07319233566522598,
0.02459990605711937,
-0.1347593516111374,
-0.09058636426925659,
-0.012703287415206432,
-0.13333186507225037,
-0.19068822264671326,
0.01801413856446743,
0.1066894680261612,
-0.01143425889313221,
0.047027282416820526,
0.09679901599884033,
-0.012726254761219025,
0.07518503069877625,
-0.04463118314743042,
-0.09744119644165039,
0.08426044136285782,
0.009694241918623447,
0.1602824628353119,
-0.2261086255311966,
-0.01397286169230938,
0.05652400478720665,
-0.06588218361139297,
0.253727525472641,
-0.07382423430681229,
-0.1413073092699051,
-0.12617814540863037,
-0.17514356970787048,
-0.10064581036567688,
0.2549555003643036,
0.09451096504926682,
0.08994711935520172,
0.0662846565246582,
0.04697180539369583,
0.025194449350237846,
-0.3292689919471741,
-0.13709846138954163,
0.0346326045691967,
0.14760908484458923,
-0.16792595386505127,
-0.20663084089756012,
-0.1982504278421402,
0.1463613212108612,
-0.17502480745315552,
0.003268014406785369,
-0.03979773819446564,
0.10530110448598862,
0.13771961629390717,
0.09368295222520828,
0.18584753572940826,
0.0028735578525811434,
-0.04926326498389244,
0.027003204450011253,
-0.018986860290169716,
0.11708199977874756,
0.21088875830173492,
0.03574620932340622,
-0.21420611441135406,
0.008670061826705933,
0.08689144998788834,
0.08468160778284073,
0.013497120700776577,
0.2250673770904541,
0.011966361664235592,
0.07215036451816559,
0.06876865774393082,
0.20286758244037628,
-0.011772495694458485,
-0.10317495465278625,
-0.004448596853762865,
-0.09513183683156967,
0.24472422897815704,
0.17114314436912537,
-0.010044455528259277,
-0.04575794190168381,
0.043353766202926636,
0.08195554465055466,
0.22368879616260529,
-0.13682235777378082,
0.08177759498357773,
-0.18041284382343292,
-0.34031739830970764,
0.06973240524530411,
-0.03819594904780388,
0.06571780145168304,
-0.07598324120044708,
0.05388496816158295,
0.0413871668279171,
-0.0881611630320549,
0.05544532462954521,
0.048902712762355804,
-0.16548198461532593,
0.19800007343292236,
0.08725231140851974,
0.09134461730718613,
0.1340557187795639,
-0.03822267800569534,
-0.09601660072803497,
0.15000823140144348,
-0.13813088834285736,
0.10810995101928711,
0.18856656551361084,
-0.008329561911523342,
-0.1637694388628006,
0.07744263857603073,
-0.005569797474890947,
0.08989612013101578,
0.01592252589762211,
-0.03364267945289612,
-0.15618103742599487,
-0.058731697499752045,
-0.03847309201955795,
-0.0792015865445137,
0.10100121051073074,
0.11256841570138931,
0.08921444416046143,
0.1714198738336563,
0.0848134309053421,
-0.02515191212296486,
-0.12830893695354462,
0.0007705432362854481,
-0.06128794327378273,
-0.18099252879619598,
0.06264114379882812,
-0.17594392597675323,
0.22504352033138275,
0.11088100075721741,
0.2217312902212143,
0.06693875789642334,
-0.07582665979862213,
-0.047727327793836594,
-0.021576600149273872,
-0.14216504991054535,
-0.06090090423822403,
-0.1307177096605301,
-0.013982455246150494,
-0.06896661967039108,
-0.010792497545480728,
0.14506910741329193,
0.07931958884000778,
0.06883878260850906,
0.30657896399497986,
0.049854569137096405,
0.04122428596019745,
-0.02506582997739315,
-0.14080922305583954,
0.067950040102005,
-0.1528443545103073,
0.21664085984230042,
-0.022846492007374763,
-0.18240772187709808,
0.17420201003551483,
0.06355039775371552,
0.0710701048374176,
-0.19001170992851257,
-0.06108872964978218,
0.011697310954332352,
-0.18464422225952148,
0.033193476498126984,
0.1087820827960968,
0.01426977850496769,
0.2221578061580658,
0.05044405534863472,
0.023668065667152405,
0.0071408385410904884,
-0.013629702851176262,
-0.023397039622068405,
0.1829267293214798,
-0.21645240485668182,
-0.14946897327899933,
-0.17480991780757904,
-0.12570999562740326,
-0.13260039687156677,
-0.02266054041683674,
0.1702650636434555,
-0.12024559080600739,
0.18675930798053741,
-0.002280671615153551,
0.02156241051852703,
-0.08319486677646637,
0.2643428146839142,
-0.039089299738407135,
0.031544290482997894,
-0.1089937835931778,
-0.09403100609779358,
-0.10893094539642334,
-0.08800897747278214,
0.08602536469697952,
0.1128276139497757,
0.002298563253134489,
-0.14944830536842346,
0.07275941967964172,
0.2604338824748993,
0.04621222987771034,
-0.06292921304702759,
-0.04410407319664955,
-0.09094976633787155,
-0.04927350953221321,
0.17569062113761902,
-0.030573096126317978,
0.12479346990585327,
0.23619991540908813,
0.056307725608348846,
-0.22453419864177704,
0.04170869663357735,
0.08673844486474991,
0.1116836667060852,
0.33786195516586304,
-0.013884589076042175,
0.14876507222652435,
-0.12454945594072342,
0.18613691627979279,
-0.0031493313144892454,
0.11313922703266144,
0.2161913961172104,
-0.08185330778360367,
0.06340830773115158,
-0.04052508994936943,
0.09244362264871597,
-0.0025411518290638924,
0.014735303819179535,
-0.08231368660926819,
-0.05815264210104942,
0.06533622741699219,
-0.011675362475216389,
0.14098688960075378,
0.08146544545888901,
-0.035308800637722015,
0.0037883620243519545,
-0.07569627463817596,
0.03942584618926048,
-0.0728728324174881,
0.0559670552611351,
0.13621261715888977,
0.06488806009292603,
-0.00867161713540554,
0.006951527204364538,
-0.07240260392427444,
0.04208500310778618,
0.13467112183570862,
0.11854007095098495,
0.10829419642686844,
-0.029342269524931908,
0.16065862774848938,
0.007338563911616802,
-0.08041120320558548,
-0.07126068323850632,
-0.008038341999053955,
-0.031094029545783997,
-0.164347842335701,
-0.04895884543657303,
0.11849164962768555,
0.041679635643959045,
-0.022496409714221954,
-0.01847587153315544,
-0.039260391145944595,
0.1658262312412262,
0.12711675465106964,
-0.19050376117229462,
0.15810279548168182,
-0.1454789936542511,
-0.0013122890377417207,
0.0313861221075058,
0.23493127524852753,
0.18536259233951569,
-0.04563204199075699,
-0.13571797311306,
0.21992243826389313,
-0.007473532110452652,
-0.15171125531196594,
-0.18437546491622925,
0.12129008769989014,
0.1930360347032547,
0.06858070194721222,
0.05333242937922478,
-0.05566481128334999,
-0.09327875077724457,
0.07483278959989548,
-0.32709431648254395,
-0.208716481924057,
0.05696209892630577,
-0.19842706620693207,
-0.1041589230298996,
0.14808760583400726,
-0.2676399350166321,
0.06795822829008102,
-0.05794944614171982,
0.029953448101878166,
0.02434832789003849,
0.01584266871213913,
0.045880530029535294,
0.015457251109182835,
-0.08939672261476517,
0.14515267312526703,
0.17131991684436798,
-0.07913481444120407,
-0.16511860489845276,
-0.034133993089199066,
0.08918309211730957,
-0.06724704802036285,
0.1317579597234726,
-0.23028744757175446,
0.02147241309285164,
-0.08242528140544891,
0.03686537593603134,
0.043673280626535416,
0.07559375464916229,
-0.00826325174421072,
-0.0035085869021713734,
-0.13730689883232117,
0.006559666711837053,
-0.15947605669498444,
-0.10240163654088974,
0.17706942558288574,
0.1418166309595108,
0.00984890665858984,
-0.009840312413871288,
0.022234676405787468,
0.08452238142490387,
0.18510250747203827,
0.22926892340183258,
-0.03562105819582939,
-0.06731892377138138,
0.0008792137959972024,
0.044480662792921066,
-0.3081204295158386,
0.03342023119330406,
0.12373864650726318,
-0.08576343208551407,
-0.06013234332203865,
0.2517208456993103,
0.03188946098089218,
-0.027719320729374886,
-0.00988815538585186,
-0.09845931828022003,
0.21608641743659973,
0.3045591413974762,
0.0853768065571785,
-0.01847953349351883,
0.10578277707099915,
-0.07274257391691208,
-0.1187974214553833,
-0.1894933432340622,
0.24746890366077423,
-0.10366235673427582,
-0.16219069063663483,
0.015372293069958687,
-0.22854094207286835,
-0.051855139434337616,
-0.11194361001253128,
0.08191657811403275,
0.17021970450878143,
-0.19779802858829498,
-0.1931164413690567,
-0.17126688361167908,
-0.006069911643862724,
0.02300100587308407,
-0.11351864784955978,
0.04900550842285156,
0.2652827203273773,
0.1549973040819168,
-0.10764018446207047,
-0.18769867718219757,
0.10158148407936096,
0.027082324028015137,
-0.01854950375854969,
0.14629828929901123,
0.11562048643827438,
-0.02832888439297676,
0.05611363798379898,
-0.09995643049478531,
-0.056469615548849106,
0.23991169035434723,
-0.11345022171735764,
-0.12468678504228592,
0.1287878006696701,
0.08075916022062302,
0.03030402399599552,
-0.0652570053935051,
0.17900606989860535,
-0.02423037774860859,
-0.1627003699541092,
-0.17173205316066742,
0.10547462105751038,
0.013672755099833012,
0.32170549035072327,
-0.06809797137975693,
0.14610901474952698,
0.013768265023827553,
0.33845651149749756,
-0.026913128793239594,
0.2750939726829529,
-0.02911747619509697,
0.11320613324642181,
-0.16421851515769958,
0.027730392292141914,
0.22859425842761993,
0.04191391170024872,
-0.029043493792414665,
0.15309306979179382,
-0.0978425070643425,
-0.12120133638381958,
-0.10438322275876999,
-0.074284128844738,
0.0774635300040245,
0.08870246261358261,
0.20002645254135132,
-0.07983127236366272,
-0.16788597404956818,
-0.11986075341701508,
-0.15750949084758759,
0.04880747199058533,
-0.02793983556330204,
-0.09649727493524551,
-0.017375554889440536,
-0.28598254919052124,
0.046730831265449524,
0.10912934690713882,
-0.02492850087583065,
0.04582434147596359,
-0.012607038021087646,
-0.061700187623500824,
0.23695668578147888,
-0.08142907172441483,
0.07362808287143707,
0.061733733862638474,
-0.10885462164878845,
0.15078143775463104,
0.08403943479061127,
0.04226382449269295,
0.011253643780946732,
-0.043686892837285995,
-0.11228855699300766,
0.05347255989909172,
0.0193202905356884,
0.20566733181476593,
0.05341624468564987,
0.037121377885341644,
0.06257809698581696,
-0.09592719376087189,
-0.06378091871738434,
-0.3326165974140167,
0.04584750905632973,
0.08070617914199829,
-0.08483467251062393,
0.07465384900569916,
0.15016688406467438,
0.015439076349139214,
-0.07814150303602219,
-0.026944274082779884,
0.3311200439929962,
0.0011993572115898132,
-0.3998493552207947,
0.003600573167204857,
-0.1241455003619194,
0.1507803499698639,
-0.07881227135658264,
-0.13141466677188873,
0.07872336357831955,
0.07078297436237335,
-0.07298871874809265,
-0.2990778684616089,
-0.12222171574831009,
-0.0009010313078761101,
0.044149186462163925,
-0.04661659151315689,
-0.01939420774579048,
0.3224085867404938,
0.013527658767998219,
-0.03725495934486389,
-0.15340279042720795,
0.011444596573710442,
0.027428237721323967,
0.01830766536295414,
0.08824610710144043,
0.09847047179937363,
-0.2062290608882904,
0.19977150857448578,
-0.20874397456645966,
-0.08869262039661407,
-0.14625926315784454,
-0.019080040976405144,
-0.15159696340560913,
-0.015062161721289158,
0.06246740743517876,
-0.07281330972909927,
0.03630872070789337,
-0.10781113803386688,
0.11626822501420975,
0.00548118632286787,
0.13345269858837128,
0.04597831144928932,
-0.044530708342790604,
0.14349766075611115,
-0.08725551515817642,
0.26783594489097595,
0.03298673406243324,
-0.03158493712544441,
0.1047205924987793,
0.05290112644433975,
0.1472608596086502,
-0.06625240296125412,
-0.045198943465948105,
-0.06610982120037079,
0.10476986318826675,
0.16439780592918396,
0.0578429214656353,
0.09057280421257019,
0.010612767189741135,
-0.12596237659454346,
-0.1305161714553833,
0.2025507390499115,
0.05977308377623558,
-0.17719373106956482,
0.02292613498866558,
0.09255896508693695,
0.08641905337572098,
-0.050518959760665894,
-0.10781047493219376,
-0.106685109436512,
-0.10179981589317322,
0.21125656366348267,
0.1287345141172409,
-0.0332103930413723,
-0.133869007229805,
-0.03277139365673065,
-0.23144203424453735,
-0.16815342009067535,
-0.11317648738622665,
-0.010627013631165028,
0.049250662326812744,
-0.051044393330812454,
-0.08224529027938843,
-0.04278751090168953,
0.04322109743952751,
-0.005268041044473648,
0.06053612008690834,
-0.14712461829185486,
0.07337115705013275
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. biopsy of an affected area of skin. (3) A minority of affected individuals (2/31 reported by Lindhurst et al ) with the AKT1 c.49G>A pathogenic variant identified in one or more tissues had the pathogenic variant identified in a peripheral blood sample. Therefore, the absence of a pathogenic variant in a peripheral blood sample is not sufficient to exclude the diagnosis.A multigene panel that includes AKT1 and other genes of interest (see Differential Diagnosis) may be considered. Note: (1) The genes included in the panel and the diagnostic sensitivity of the testing used for each gene vary by laboratory and are likely to change over time. (2) Some multigene panels may include genes not associated with the condition discussed in this GeneReview; thus, clinicians need to determine which multigene panel is most likely to identify the genetic cause of the condition at the most reasonable cost while limiting identification of pathogenic variants in genes that do | [
-0.07776599377393723,
-0.04301734268665314,
-0.07615716755390167,
-0.2642859220504761,
0.04266262799501419,
0.00937922578305006,
0.07343073189258575,
-0.14963310956954956,
0.03830495476722717,
0.023512938991189003,
0.14953218400478363,
0.00019840270397253335,
-0.022415975108742714,
-0.010645614005625248,
-0.19280748069286346,
0.24410326778888702,
0.002135898917913437,
0.07673264294862747,
-0.05207154154777527,
0.20094245672225952,
0.1108030453324318,
-0.15238142013549805,
0.03435226157307625,
-0.006388824433088303,
0.053549278527498245,
-0.26399150490760803,
0.28791627287864685,
0.1798250526189804,
-0.11267697066068649,
-0.03618459403514862,
-0.12069042026996613,
0.023247702047228813,
-0.13405612111091614,
-0.10720954835414886,
-0.17167973518371582,
-0.2761825621128082,
-0.09943537414073944,
0.04705542325973511,
0.109828881919384,
-0.02919938787817955,
0.07396472245454788,
0.06279648840427399,
0.13529956340789795,
-0.13962826132774353,
0.06624029576778412,
-0.17807430028915405,
0.08193838596343994,
-0.013527875766158104,
0.12322098016738892,
0.21607467532157898,
0.011481896042823792,
0.07335818558931351,
0.031486425548791885,
-0.07086591422557831,
0.09070873260498047,
-0.07888386398553848,
-0.015026991255581379,
-0.2631903886795044,
-0.2680436372756958,
-0.04292046278715134,
0.21101394295692444,
0.005624191369861364,
-0.06303055584430695,
-0.15114726126194,
0.10020489245653152,
-0.1437094509601593,
0.023719800636172295,
0.1848822832107544,
0.12147273868322372,
0.00982959195971489,
0.17941823601722717,
0.015625296160578728,
0.17446553707122803,
-0.16411106288433075,
0.04702109098434448,
0.010963544249534607,
0.0972466990351677,
-0.10343939810991287,
0.06257231533527374,
-0.2831399142742157,
-0.11411984264850616,
-0.19314220547676086,
0.04740991070866585,
0.10015054792165756,
-0.05791877955198288,
-0.13575156033039093,
-0.08473650366067886,
-0.07971081137657166,
-0.014954734593629837,
0.11903552711009979,
-0.03690215200185776,
0.12053696811199188,
0.0747169628739357,
0.14584483206272125,
0.13413743674755096,
0.04863519221544266,
0.19655278325080872,
0.08505234867334366,
-0.13514448702335358,
0.11391196399927139,
0.16931958496570587,
0.08011595159769058,
-0.18766382336616516,
-0.050003137439489365,
0.12207835167646408,
0.008978676982223988,
0.08548631519079208,
-0.054178718477487564,
-0.0044012246653437614,
-0.06287787109613419,
-0.05344058573246002,
0.12611791491508484,
-0.056796420365571976,
-0.0059768459759652615,
-0.03873428329825401,
-0.1332588493824005,
-0.09251628071069717,
0.05470294505357742,
-0.08899859338998795,
0.048043545335531235,
0.03277670219540596,
-0.08741439878940582,
-0.11474721878767014,
-0.07573210448026657,
-0.052467990666627884,
-0.03549685701727867,
0.14281675219535828,
-0.2532025873661041,
0.08617488294839859,
0.07055272161960602,
0.04597524181008339,
0.0035859260242432356,
0.11557752639055252,
-0.0018673214362934232,
0.12348102778196335,
-0.06877794861793518,
-0.12279721349477768,
-0.09286914765834808,
0.09082271158695221,
-0.030738266184926033,
0.13677605986595154,
0.24206818640232086,
0.3323415517807007,
0.06091443821787834,
-0.10350751876831055,
0.13059762120246887,
0.1957508623600006,
-0.17698055505752563,
-0.013439218513667583,
-0.09856970608234406,
0.041923899203538895,
-0.1319446563720703,
0.27082329988479614,
0.08704841881990433,
-0.009946975857019424,
-0.026000572368502617,
-0.07646942138671875,
0.27625036239624023,
-0.1850074827671051,
0.10766544193029404,
0.037357084453105927,
0.01661982759833336,
-0.004423207603394985,
-0.014470260590314865,
0.20134508609771729,
0.09118674695491791,
0.11505935341119766,
-0.09617382287979126,
0.1480003148317337,
0.06274283677339554,
-0.07399135082960129,
0.13346125185489655,
-0.005138421431183815,
0.15199315547943115,
0.0784577950835228,
0.05097881704568863,
-0.005219410639256239,
0.09487024694681168,
0.008179220370948315,
-0.0741444006562233,
0.02850034087896347,
-0.024129433557391167,
-0.07938747107982635,
-0.09971199929714203,
-0.10264220833778381,
-0.06481650471687317,
-0.05170465633273125,
0.10451086610555649,
-0.18248474597930908,
0.05906768515706062,
0.06908074021339417,
-0.1200287938117981,
-0.06918509304523468,
-0.13445603847503662,
0.19150960445404053,
-0.17357026040554047,
-0.05855049565434456,
0.05732462555170059,
-0.00047230496420525014,
-0.23611924052238464,
-0.008312106132507324,
-0.06301984190940857,
-0.070185087621212,
-0.08689437061548233,
0.019749263301491737,
0.11173637956380844,
0.011905818246304989,
-0.10450558364391327,
0.10125301033258438,
0.027334829792380333,
0.15861791372299194,
0.3212841749191284,
-0.07745938748121262,
0.048649441450834274,
-0.0014435501070693135,
-0.050501007586717606,
-0.00009200502245221287,
-0.17487473785877228,
0.03641413524746895,
0.3507584035396576,
-0.17439806461334229,
0.19194307923316956,
0.04583818465471268,
-0.16515633463859558,
-0.11394613236188889,
0.10337596386671066,
-0.019377946853637695,
-0.02603299729526043,
0.0421200729906559,
0.01595107465982437,
0.016541410237550735,
-0.15018953382968903,
-0.09754625707864761,
-0.010669952258467674,
-0.17786571383476257,
-0.15394391119480133,
0.0066373771987855434,
0.10744816064834595,
-0.0022732431534677744,
0.015586051158607006,
0.11204111576080322,
-0.0601835772395134,
0.06514431536197662,
0.021590419113636017,
-0.012930364347994328,
0.07560422271490097,
-0.01219459529966116,
0.09151279926300049,
-0.24119722843170166,
0.04167860373854637,
-0.008541003800928593,
-0.01661360263824463,
0.1800573319196701,
-0.1422305852174759,
-0.2124837189912796,
-0.22081172466278076,
-0.13563606142997742,
-0.07708700001239777,
0.20824554562568665,
0.0363520123064518,
0.08895362168550491,
0.015637410804629326,
0.15445905923843384,
0.02480962686240673,
-0.23142099380493164,
-0.03925154730677605,
-0.059260208159685135,
0.11009959131479263,
-0.24588942527770996,
-0.08854217082262039,
-0.10843763500452042,
0.15855279564857483,
-0.1308249980211258,
0.059982579201459885,
-0.057193856686353683,
0.0822911262512207,
0.11186530441045761,
0.10469476133584976,
0.20276924967765808,
0.009342650882899761,
-0.01630922220647335,
-0.02795315347611904,
-0.05417191982269287,
0.1080474928021431,
0.22625376284122467,
0.05053015053272247,
-0.24255234003067017,
0.05282869189977646,
0.02294120006263256,
0.042321957647800446,
0.04305420443415642,
0.20318949222564697,
0.03378847613930702,
0.04208552464842796,
0.048754699528217316,
0.19693678617477417,
-0.013052710331976414,
-0.031075116246938705,
0.025204451754689217,
-0.10869289934635162,
0.3082330524921417,
0.14468304812908173,
-0.00836831983178854,
-0.051228009164333344,
-0.08231712132692337,
-0.03243613988161087,
0.12250497192144394,
-0.1687769740819931,
0.14564262330532074,
-0.11985891312360764,
-0.24830961227416992,
0.13341593742370605,
-0.14813892543315887,
0.11214853078126907,
0.015251279808580875,
0.0878925696015358,
-0.05692532658576965,
-0.05677378922700882,
0.11921589076519012,
0.13579118251800537,
-0.14176897704601288,
0.14762000739574432,
0.09226752817630768,
0.009202903136610985,
0.07297024875879288,
-0.08493572473526001,
-0.2290058135986328,
0.07961831986904144,
-0.11861222982406616,
0.07110358029603958,
0.12808546423912048,
0.04993882775306702,
-0.12719963490962982,
0.06275251507759094,
0.04098328948020935,
0.023225892335176468,
-0.045616596937179565,
-0.08170635998249054,
-0.22580386698246002,
-0.04933665692806244,
-0.08129825443029404,
-0.13424775004386902,
0.08924684673547745,
0.16044564545154572,
0.05413762852549553,
0.17844103276729584,
0.07850632071495056,
-0.019933033734560013,
-0.09515589475631714,
-0.05523664876818657,
-0.020318418741226196,
-0.171128049492836,
0.02654787339270115,
-0.22466161847114563,
0.21272505819797516,
0.0202558021992445,
0.21876074373722076,
0.1702665537595749,
-0.0704720988869667,
0.031137553974986076,
-0.04652651399374008,
0.005022958852350712,
-0.08228614181280136,
-0.04144991561770439,
0.06584686785936356,
-0.09858686476945877,
0.08176112920045853,
0.09758256375789642,
0.180337592959404,
0.07143045961856842,
0.35384616255760193,
0.0667124092578888,
0.023344488814473152,
-0.012577390298247337,
-0.06021144241094589,
0.058523572981357574,
-0.09245670586824417,
0.1805988997220993,
-0.11417199671268463,
-0.25304052233695984,
0.12634463608264923,
-0.052855730056762695,
0.010687058791518211,
-0.237541064620018,
-0.025900602340698242,
0.14968228340148926,
-0.10325407236814499,
-0.004792548716068268,
0.03661347180604935,
0.003310758387669921,
0.18530578911304474,
-0.03809752315282822,
0.0283528883010149,
-0.05948490649461746,
-0.0232393741607666,
0.03320370987057686,
0.11429011821746826,
-0.1689445525407791,
-0.09883712232112885,
-0.20345915853977203,
-0.07154659181833267,
-0.2151183784008026,
-0.06791552901268005,
0.16091640293598175,
-0.09812044352293015,
0.07221090793609619,
0.048514820635318756,
0.09411031752824783,
-0.006014681421220303,
0.2305890917778015,
-0.10557617992162704,
-0.009142527356743813,
-0.07009755820035934,
-0.09723009169101715,
0.019810717552900314,
-0.11689122766256332,
0.01201066467911005,
0.09499678015708923,
-0.076536625623703,
-0.11977292597293854,
0.09734198451042175,
0.23396871984004974,
0.07064198702573776,
-0.0958671048283577,
-0.04333905130624771,
-0.012109838426113129,
-0.09518709778785706,
0.10719509422779083,
0.009457181207835674,
0.10128257423639297,
0.20987266302108765,
0.045950111001729965,
-0.14278919994831085,
0.10369458794593811,
0.007194668520241976,
0.13318681716918945,
0.29045289754867554,
-0.08060148358345032,
0.07919582724571228,
-0.2113327533006668,
0.19021856784820557,
-0.10215924680233002,
0.04925450310111046,
0.11347784101963043,
-0.01765824854373932,
0.0966956615447998,
-0.017409084364771843,
0.13010001182556152,
0.02587810531258583,
0.013666877523064613,
-0.02893977239727974,
0.029075924307107925,
0.0570906400680542,
-0.007950244471430779,
0.023553913459181786,
0.07012607902288437,
-0.02821073867380619,
-0.1407366842031479,
-0.03707660734653473,
-0.028749214485287666,
-0.17054732143878937,
0.09072714298963547,
0.12047254294157028,
0.06196849048137665,
-0.008788359351456165,
0.011711201630532742,
-0.01792026124894619,
0.05087246000766754,
0.19067847728729248,
0.07042065262794495,
0.040027353912591934,
0.000695531431119889,
0.11074647307395935,
0.06313569098711014,
-0.06692223995923996,
-0.049070004373788834,
-0.017548220232129097,
-0.00021241600916255265,
-0.14011745154857635,
-0.05754634365439415,
0.10095517337322235,
-0.016392437741160393,
-0.09686559438705444,
-0.0667264387011528,
0.017857160419225693,
0.15844057500362396,
0.06351758539676666,
-0.13716962933540344,
0.041286688297986984,
-0.1458863765001297,
0.011793251149356365,
0.09019400179386139,
0.2061711698770523,
0.2558468282222748,
-0.03734852373600006,
-0.1450279951095581,
0.15876010060310364,
-0.12138819694519043,
-0.1753433644771576,
-0.13214191794395447,
0.10598929971456528,
0.24407149851322174,
0.1784970760345459,
0.00578649528324604,
-0.13816729187965393,
-0.1334300935268402,
0.028987087309360504,
-0.1861194223165512,
-0.17448315024375916,
0.003509174333885312,
-0.21308459341526031,
-0.05607210844755173,
0.08129728585481644,
-0.15584412217140198,
-0.0005248207598924637,
-0.010576429776847363,
-0.03168787062168121,
-0.026004264131188393,
0.0840749517083168,
0.09658557176589966,
0.03945447504520416,
-0.11041688919067383,
0.08471693843603134,
0.1767110526561737,
-0.048847757279872894,
-0.17824478447437286,
-0.052273478358983994,
0.051250774413347244,
-0.1794494092464447,
0.039794713258743286,
-0.22217972576618195,
-0.030179958790540695,
-0.001299707917496562,
0.06767083704471588,
0.10431654006242752,
0.10378774255514145,
0.018927527591586113,
-0.054386816918849945,
-0.2822889983654022,
0.0853581503033638,
-0.20981718599796295,
-0.05859425663948059,
0.18418723344802856,
0.006650004535913467,
0.02917085774242878,
-0.01969178020954132,
0.037801340222358704,
0.16257737576961517,
0.1431698203086853,
0.279730886220932,
-0.08068318665027618,
-0.1028892919421196,
0.05850977823138237,
0.09117446839809418,
-0.18850532174110413,
0.00581034179776907,
0.16197635233402252,
-0.11082568019628525,
-0.10024558752775192,
0.2349732369184494,
0.07541736215353012,
0.0012017362751066685,
-0.04926406592130661,
-0.027676943689584732,
0.18432582914829254,
0.21109682321548462,
0.13509570062160492,
-0.015329633839428425,
0.012007362209260464,
0.018087882548570633,
-0.17105087637901306,
-0.09243639558553696,
0.13707225024700165,
-0.07089635729789734,
-0.12086965143680573,
-0.023116936907172203,
-0.05747200921177864,
0.015185521915555,
-0.06448319554328918,
0.029629144817590714,
0.15386149287223816,
-0.1835346817970276,
-0.15222665667533875,
-0.14973407983779907,
-0.005774833727627993,
0.02991289086639881,
-0.1528548151254654,
0.018725136294960976,
0.21236605942249298,
0.058954574167728424,
-0.17468751966953278,
-0.10948509722948074,
0.15174929797649384,
0.08301518857479095,
-0.03243046626448631,
0.09464994817972183,
0.1620408296585083,
-0.017483146861195564,
0.01295467372983694,
-0.10575965791940689,
-0.08887547999620438,
0.2062767595052719,
-0.13118797540664673,
-0.16910848021507263,
0.12597991526126862,
0.052251651883125305,
0.06310230493545532,
-0.11405350267887115,
0.20612028241157532,
-0.02465062588453293,
-0.16178646683692932,
-0.13482044637203217,
-0.013746457174420357,
0.02535908669233322,
0.31684204936027527,
-0.02773558348417282,
0.16989995539188385,
0.013465500436723232,
0.282099187374115,
-0.008900285698473454,
0.20275066792964935,
-0.0341833233833313,
0.024406926706433296,
-0.2065291702747345,
0.05162006616592407,
0.20195931196212769,
0.09126990288496017,
-0.04417435824871063,
0.1884777694940567,
-0.07340899109840393,
-0.07643774896860123,
0.006883359979838133,
0.017752032727003098,
-0.026319056749343872,
0.038330692797899246,
0.14902424812316895,
-0.17503811419010162,
-0.1543310582637787,
-0.10923551023006439,
-0.0368611104786396,
0.012934119440615177,
-0.00552762858569622,
-0.1402752846479416,
-0.05123598873615265,
-0.17391815781593323,
0.060978904366493225,
0.1421753168106079,
-0.04465266689658165,
0.00463520921766758,
-0.04976023733615875,
-0.023480772972106934,
0.178886279463768,
-0.03417446091771126,
-0.015205762349069118,
0.155317023396492,
-0.11900380998849869,
0.26143878698349,
0.15249668061733246,
0.06771659851074219,
-0.030762391164898872,
-0.05157630890607834,
-0.05678850784897804,
-0.03876703232526779,
0.023514743894338608,
0.16374120116233826,
0.10724833607673645,
-0.05248602479696274,
0.07183904945850372,
-0.13349035382270813,
-0.14941348135471344,
-0.2811584174633026,
0.031042076647281647,
0.05281675606966019,
-0.08042348176240921,
0.017454372718930244,
0.05360341817140579,
0.07268446683883667,
-0.006124204024672508,
-0.00572158582508564,
0.26621371507644653,
0.007548339664936066,
-0.25114503502845764,
-0.04176134616136551,
-0.10359630733728409,
0.0881863608956337,
-0.024060580879449844,
-0.18189284205436707,
0.00433276267722249,
0.12612859904766083,
-0.04571113735437393,
-0.2717731297016144,
-0.08114496618509293,
-0.00325100333429873,
0.06871689856052399,
-0.0623091422021389,
0.0635572075843811,
0.3595602214336395,
-0.006839548237621784,
-0.006115711759775877,
-0.23476973176002502,
0.07987120747566223,
-0.015900835394859314,
-0.015764905139803886,
0.11345045268535614,
-0.0007716460386291146,
-0.1588963270187378,
0.1509546935558319,
-0.10732625424861908,
-0.01807902194559574,
-0.0924440398812294,
-0.11697328835725784,
-0.22440150380134583,
0.03572709485888481,
0.12159312516450882,
-0.14745695888996124,
0.11843627691268921,
-0.08818462491035461,
0.11755592375993729,
0.014005515724420547,
-0.006133854854851961,
-0.0022361259907484055,
-0.004819886293262243,
0.09666986763477325,
-0.0651502013206482,
0.16351626813411713,
0.026155993342399597,
-0.07696114480495453,
0.08695383369922638,
0.057084470987319946,
0.079582579433918,
-0.048564162105321884,
-0.08999992161989212,
-0.022328361868858337,
-0.06186114624142647,
0.087992362678051,
0.057420674711465836,
0.12343072891235352,
-0.04368836432695389,
0.002097796183079481,
-0.1503143608570099,
0.1820105016231537,
-0.050035733729600906,
-0.12352071702480316,
0.0508633628487587,
0.03302881494164467,
0.0828295424580574,
0.006340030115097761,
-0.13833168148994446,
-0.15783581137657166,
-0.014392704702913761,
0.2330917865037918,
0.12526145577430725,
0.04911208152770996,
-0.11811014264822006,
-0.018297316506505013,
-0.2559376060962677,
-0.1871229112148285,
-0.10443618893623352,
0.08409758657217026,
0.008814576081931591,
0.023770861327648163,
-0.03061438910663128,
-0.10133807361125946,
0.034395184367895126,
-0.0873422622680664,
0.12188629060983658,
-0.06976768374443054,
0.048778582364320755
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. see Differential Diagnosis) may be considered. Note: (1) The genes included in the panel and the diagnostic sensitivity of the testing used for each gene vary by laboratory and are likely to change over time. (2) Some multigene panels may include genes not associated with the condition discussed in this GeneReview; thus, clinicians need to determine which multigene panel is most likely to identify the genetic cause of the condition at the most reasonable cost while limiting identification of pathogenic variants in genes that do not explain the underlying phenotype. (3) Methods used in a panel may include sequence analysis, deletion/duplication analysis, and/or other non-sequencing-based tests.For an introduction to multigene panels click here. More detailed information for clinicians ordering genetic tests can be found here.More comprehensive genomic testing (when available) including exome sequencing and genome sequencing may be considered. Such testing may provide or suggest a diagnosis not previously considered (e.g., a variant | [
0.02804603800177574,
-0.008310017175972462,
-0.09276659041643143,
-0.17745891213417053,
-0.03849504142999649,
-0.16547122597694397,
0.10085774213075638,
-0.049300167709589005,
-0.008164536207914352,
0.1156214028596878,
0.23227891325950623,
0.0794127881526947,
0.017295731231570244,
-0.04472953826189041,
-0.1504145711660385,
0.16001801192760468,
0.0809531882405281,
-0.12108663469552994,
-0.029112840071320534,
0.23305664956569672,
0.10810306668281555,
-0.023378020152449608,
-0.13212773203849792,
0.04795535281300545,
0.08671745657920837,
-0.08700676262378693,
0.20862330496311188,
0.11824627220630646,
0.06541973352432251,
-0.0013852377887815237,
-0.2672523856163025,
-0.042662363499403,
-0.2674461007118225,
-0.17754195630550385,
-0.16060443222522736,
-0.3288356363773346,
-0.07786881178617477,
0.06006913632154465,
0.043918926268815994,
-0.1264507919549942,
0.006834413390606642,
0.06689867377281189,
0.0206519216299057,
-0.19597561657428741,
0.14301322400569916,
-0.11518795043230057,
0.05717863142490387,
-0.08448263257741928,
0.2632133364677429,
0.23270179331302643,
0.11575383692979813,
-0.042790737003088,
-0.013120713643729687,
0.00569356232881546,
0.09465564042329788,
-0.10515402257442474,
-0.1527363508939743,
-0.267762154340744,
-0.40993672609329224,
-0.04926454648375511,
0.18908338248729706,
0.0435447096824646,
-0.114927276968956,
-0.1932397186756134,
0.1400616466999054,
-0.1786634773015976,
0.06663061678409576,
0.11079462617635727,
0.00023165976745076478,
-0.08700000494718552,
0.149099662899971,
-0.05372658371925354,
0.12258829176425934,
-0.14705759286880493,
-0.006971095222979784,
0.10422372072935104,
0.14020566642284393,
-0.15520909428596497,
0.12973985075950623,
-0.31062546372413635,
-0.03405826538801193,
-0.23121170699596405,
0.1777552366256714,
-0.03813454136252403,
-0.08232007175683975,
-0.10832636803388596,
-0.05256372317671776,
0.032916560769081116,
0.07162894308567047,
0.012895114719867706,
0.09377681463956833,
0.007270295638591051,
0.03883417695760727,
0.0936066284775734,
0.17669226229190826,
-0.16753815114498138,
0.18433944880962372,
-0.005782770924270153,
0.0634293407201767,
0.21701587736606598,
0.16552768647670746,
0.0028894171118736267,
0.04023230820894241,
-0.15501508116722107,
0.13776853680610657,
0.04372865706682205,
-0.034894224256277084,
-0.06694485992193222,
-0.08682291954755783,
-0.04167817160487175,
0.0016935394378378987,
0.2072795182466507,
-0.0785108208656311,
-0.07291550189256668,
-0.09613793343305588,
-0.14022397994995117,
0.08218511939048767,
0.02246314100921154,
0.1321978121995926,
-0.17120683193206787,
0.017799828201532364,
-0.21113017201423645,
-0.07962921261787415,
0.029501942917704582,
-0.003016815520823002,
-0.09088841080665588,
0.23768606781959534,
-0.23429615795612335,
0.0009107342921197414,
0.04292457923293114,
0.04085676372051239,
0.09998062998056412,
0.11348007619380951,
-0.12085530906915665,
0.09208789467811584,
0.04802706092596054,
-0.10166171193122864,
-0.21018154919147491,
0.18402159214019775,
-0.11590776592493057,
0.15075713396072388,
0.208530992269516,
0.32035040855407715,
-0.1002640426158905,
0.028939934447407722,
0.16460469365119934,
-0.000006352818218147149,
-0.20550425350666046,
-0.12446003407239914,
-0.15159133076667786,
0.20534810423851013,
-0.14118120074272156,
0.1597726196050644,
0.0408824160695076,
-0.0730489194393158,
-0.13291475176811218,
-0.12414076179265976,
0.19504095613956451,
-0.22716030478477478,
0.18285056948661804,
0.11794456094503403,
-0.027287917211651802,
-0.01599344238638878,
-0.07481073588132858,
0.16297855973243713,
0.11659318953752518,
0.2304505556821823,
0.0821516364812851,
0.06537075340747833,
-0.032192617654800415,
-0.13145440816879272,
0.10631672292947769,
0.05737534537911415,
0.167056143283844,
0.06193213537335396,
-0.025701187551021576,
0.16873465478420258,
0.05186827480792999,
-0.043694719672203064,
-0.0008304311195388436,
0.10037671774625778,
0.09619317948818207,
-0.07101767510175705,
-0.12613609433174133,
-0.16985493898391724,
-0.0028255919460207224,
-0.05358485132455826,
0.07798881083726883,
-0.19600306451320648,
-0.013710319064557552,
0.21232633292675018,
-0.1904115229845047,
-0.026909204199910164,
-0.09033528715372086,
0.18708527088165283,
-0.19412831962108612,
-0.14433351159095764,
0.05557361617684364,
-0.045285601168870926,
-0.181003600358963,
0.059624820947647095,
-0.05986861512064934,
0.0057931579649448395,
-0.00012374688230920583,
-0.007168381009250879,
0.07702351361513138,
0.1442740112543106,
-0.14184562861919403,
0.10279832035303116,
-0.12223366647958755,
0.18001067638397217,
0.25184276700019836,
-0.2131159007549286,
0.2357426881790161,
0.03900976851582527,
-0.10538831353187561,
-0.06000921502709389,
-0.15263526141643524,
0.047775570303201675,
0.41010525822639465,
-0.2992994785308838,
0.11814320087432861,
-0.12820082902908325,
-0.25128400325775146,
-0.04301099106669426,
0.13374483585357666,
0.056063175201416016,
-0.08962814509868622,
0.09252303093671799,
0.0316879041492939,
0.004191202111542225,
-0.06737512350082397,
-0.14676591753959656,
0.14086879789829254,
-0.2751908004283905,
-0.21255242824554443,
-0.08211254328489304,
0.23119434714317322,
0.1782573014497757,
0.01771162636578083,
0.12308280915021896,
-0.01790541224181652,
0.0732194185256958,
0.20352773368358612,
0.04502502828836441,
0.1844136267900467,
0.021239403635263443,
-0.006850176956504583,
-0.11851765215396881,
0.07899044454097748,
0.16466130316257477,
-0.08472800999879837,
0.057361211627721786,
-0.014694676734507084,
-0.20047596096992493,
-0.2336333692073822,
-0.02238999307155609,
-0.16458071768283844,
0.12696592509746552,
-0.1499166339635849,
-0.03687772899866104,
0.14355595409870148,
0.26309114694595337,
0.12116112560033798,
-0.18268388509750366,
0.09487605839967728,
-0.16885365545749664,
0.13938353955745697,
-0.08760451525449753,
-0.13755564391613007,
-0.1785135716199875,
0.1217203438282013,
-0.007613138761371374,
0.18091312050819397,
0.04585641995072365,
0.03643934801220894,
0.08309587836265564,
-0.010240079835057259,
0.09140867739915848,
0.04614296928048134,
0.01600728929042816,
0.06471630930900574,
0.020270779728889465,
0.04530297964811325,
0.13524861633777618,
0.09107629954814911,
-0.2936187982559204,
0.21536065638065338,
0.08177175372838974,
-0.16342714428901672,
0.05964786559343338,
0.17191173136234283,
0.10500622540712357,
-0.052742768079042435,
-0.02364523522555828,
0.15309828519821167,
-0.08216751366853714,
-0.03782906383275986,
0.09912269562482834,
-0.052672725170850754,
0.3822716772556305,
0.07140513509511948,
-0.1937786042690277,
-0.0620984323322773,
-0.22458793222904205,
0.06325142085552216,
-0.051726069301366806,
-0.09598802775144577,
0.03728852421045303,
-0.04565361887216568,
-0.07236173748970032,
0.048548031598329544,
-0.17669624090194702,
0.10483559966087341,
0.19098110496997833,
0.07700034230947495,
-0.18878154456615448,
0.023911744356155396,
0.09424722194671631,
0.04122751206159592,
0.04624417796730995,
0.08060392737388611,
0.27223560214042664,
0.051781490445137024,
0.04461381584405899,
-0.2197369486093521,
-0.15166109800338745,
0.04830873757600784,
-0.24903051555156708,
0.15952369570732117,
-0.10656989365816116,
0.03274469077587128,
-0.05717000365257263,
-0.179242804646492,
0.09967426210641861,
0.059889256954193115,
-0.010382954962551594,
-0.15906430780887604,
-0.13346964120864868,
0.025325685739517212,
-0.03073127195239067,
-0.3611734211444855,
0.1893463134765625,
0.14635366201400757,
-0.01685458794236183,
0.14054109156131744,
0.10455198585987091,
0.02620399370789528,
-0.07513351738452911,
-0.04363458976149559,
-0.0431739017367363,
-0.1363305151462555,
-0.08540557324886322,
-0.2667023539543152,
0.2869163155555725,
0.10182388126850128,
0.209428071975708,
0.15410412847995758,
-0.08896729350090027,
-0.08041699230670929,
-0.07759543508291245,
0.10609032213687897,
-0.03431149199604988,
0.11875034868717194,
-0.004129542037844658,
-0.05113297700881958,
-0.08530163019895554,
-0.006699963938444853,
0.31420838832855225,
0.04382213577628136,
0.10869166254997253,
0.025912415236234665,
0.0025725667364895344,
-0.05851702392101288,
0.12423569709062576,
0.08579869568347931,
-0.04762488231062889,
0.24439629912376404,
-0.06695245951414108,
-0.15273356437683105,
-0.1044626235961914,
0.09687374532222748,
-0.056252721697092056,
-0.240061953663826,
0.006429068744182587,
0.4448119103908539,
-0.14065127074718475,
0.07684340327978134,
-0.028793057426810265,
-0.08667287230491638,
0.1674841046333313,
-0.012093517929315567,
0.06031768023967743,
0.1478332132101059,
-0.11057395488023758,
0.21766893565654755,
-0.04849283769726753,
-0.1651439219713211,
-0.06982476264238358,
-0.2183915078639984,
-0.07878146320581436,
-0.17031517624855042,
0.008047046139836311,
0.24335041642189026,
0.01954312063753605,
0.045212745666503906,
0.029476962983608246,
0.11493784934282303,
-0.02945837937295437,
0.1614505499601364,
-0.04210129380226135,
0.008195780217647552,
-0.07573706656694412,
-0.028655361384153366,
0.06392476707696915,
-0.12361542135477066,
-0.14046235382556915,
0.04076728597283363,
-0.03173786401748657,
-0.10176967084407806,
0.06447149813175201,
0.00782700628042221,
0.16466262936592102,
-0.09573782980442047,
-0.03007248044013977,
0.034224625676870346,
-0.26678356528282166,
0.009068973362445831,
0.010672932490706444,
-0.08546354621648788,
0.14093895256519318,
0.06683982163667679,
-0.14055302739143372,
0.2997188866138458,
-0.09252598881721497,
0.10328277200460434,
0.12445174902677536,
-0.19137735664844513,
0.1606481522321701,
-0.19057026505470276,
0.09384676814079285,
-0.20197297632694244,
0.055749498307704926,
0.031122306361794472,
0.05952184274792671,
0.042349446564912796,
-0.04331861063838005,
0.03755834698677063,
0.007853088900446892,
0.10789112001657486,
-0.07519900053739548,
0.005063226912170649,
-0.04397508502006531,
-0.09051930159330368,
0.13490764796733856,
0.14754414558410645,
-0.12787850201129913,
-0.14228366315364838,
-0.059402137994766235,
-0.15400856733322144,
-0.18425092101097107,
0.23141349852085114,
0.043485574424266815,
0.03038649447262287,
-0.06813069432973862,
0.06653393805027008,
-0.019129548221826553,
0.00023324674111790955,
0.1367989480495453,
-0.028150172904133797,
0.051334135234355927,
0.12072838842868805,
0.22320611774921417,
-0.012996921315789223,
0.00020206006593070924,
0.05376492813229561,
-0.08471338450908661,
0.0967637374997139,
-0.03067726083099842,
-0.09252316504716873,
-0.06919864565134048,
-0.07643453031778336,
-0.05364416912198067,
-0.18072447180747986,
-0.02901245839893818,
0.09046950191259384,
-0.02709072083234787,
-0.11336752027273178,
-0.13431203365325928,
-0.3185683786869049,
0.0006435778923332691,
0.09130499511957169,
-0.03528213873505592,
0.18044695258140564,
-0.03203043341636658,
-0.10868503153324127,
-0.027722222730517387,
-0.005034143570810556,
-0.1573646068572998,
-0.20017896592617035,
0.07653988152742386,
0.34278902411460876,
0.12129855155944824,
0.0036424098070710897,
-0.1099153459072113,
-0.17093691229820251,
0.08289530128240585,
-0.0817275196313858,
-0.07564964145421982,
0.02811533957719803,
-0.17233142256736755,
-0.13851545751094818,
0.13815130293369293,
-0.022304268553853035,
-0.2221943438053131,
-0.03196517750620842,
-0.060218989849090576,
-0.11530905216932297,
0.06787475198507309,
0.13936938345432281,
-0.016906997188925743,
-0.03699755296111107,
0.12325941771268845,
0.092465341091156,
0.05424019694328308,
-0.22944357991218567,
-0.0390416719019413,
0.07543351501226425,
-0.08372745662927628,
-0.10222231596708298,
-0.17744310200214386,
-0.08293629437685013,
0.045355334877967834,
0.06593801826238632,
0.25910258293151855,
0.12417860329151154,
-0.0051072705537080765,
-0.0730462372303009,
-0.27398350834846497,
0.08610489219427109,
-0.21153782308101654,
0.013550449162721634,
0.21091724932193756,
-0.07353449612855911,
0.09695734828710556,
-0.10147979110479355,
-0.05635964125394821,
0.21208998560905457,
0.12152750045061111,
0.06512792408466339,
-0.10374162346124649,
-0.02200104482471943,
0.15295659005641937,
0.10341471433639526,
-0.05810246989130974,
-0.1825607717037201,
0.16701485216617584,
-0.04924900457262993,
-0.023439185693860054,
0.2034357488155365,
0.0018765042768791318,
0.0881425216794014,
0.046134691685438156,
-0.05636540800333023,
0.1677992343902588,
0.1339017152786255,
0.0471089743077755,
0.14361466467380524,
-0.008088226430118084,
0.305475652217865,
-0.11034674197435379,
-0.05878366157412529,
0.1307690292596817,
-0.06718738377094269,
-0.03366575762629509,
-0.005012942478060722,
0.015176057815551758,
-0.03191930055618286,
-0.13406287133693695,
-0.023436415940523148,
-0.02921593002974987,
-0.19038690626621246,
-0.03388788551092148,
-0.1414557546377182,
-0.05237233638763428,
0.0263303741812706,
-0.23023083806037903,
0.10600869357585907,
0.20450761914253235,
-0.003512193216010928,
-0.22957314550876617,
-0.09982620924711227,
0.2704516649246216,
0.03838900849223137,
-0.05137759819626808,
-0.12397640943527222,
0.1892186403274536,
0.04041951522231102,
0.010489721782505512,
-0.17592206597328186,
-0.03795890882611275,
0.1804807037115097,
-0.18875646591186523,
-0.1271902322769165,
0.07072623819112778,
0.20827241241931915,
-0.018136804923415184,
-0.16414670646190643,
0.27090784907341003,
0.07994664460420609,
-0.19012774527072906,
-0.1560613512992859,
0.08363102376461029,
0.020930206403136253,
0.2463010549545288,
-0.010087408125400543,
0.15908153355121613,
-0.12297485023736954,
0.2602730989456177,
0.08211944997310638,
0.29225921630859375,
-0.2382747083902359,
-0.09769602119922638,
-0.3041948974132538,
0.11196674406528473,
0.20694446563720703,
0.03177947551012039,
-0.13183040916919708,
0.14496542513370514,
-0.04666543006896973,
0.14795145392417908,
0.020118379965424538,
-0.049161359667778015,
-0.01769137755036354,
0.07920075953006744,
0.1638334095478058,
-0.10916943103075027,
-0.2134953737258911,
-0.16680440306663513,
-0.01860545203089714,
-0.09776097536087036,
0.05068840831518173,
-0.12080976366996765,
0.13462036848068237,
-0.057412803173065186,
-0.008143088780343533,
0.08104732632637024,
-0.1708492934703827,
-0.1785365343093872,
-0.1883372962474823,
-0.08136701583862305,
0.156402587890625,
0.025307979434728622,
-0.03572038188576698,
0.27895107865333557,
-0.014726581983268261,
0.39727842807769775,
0.09467218071222305,
-0.05040394887328148,
-0.06124124675989151,
0.0244354959577322,
-0.06230243295431137,
-0.09072669595479965,
0.051055070012807846,
0.14541053771972656,
0.08921054750680923,
-0.03429418429732323,
0.1039925217628479,
-0.18258006870746613,
-0.11601020395755768,
-0.15701167285442352,
-0.03441934660077095,
0.0349227711558342,
-0.006617800798267126,
0.11198875308036804,
0.055699050426483154,
0.3407387137413025,
0.013125119730830193,
-0.007071176078170538,
0.250229150056839,
0.07060158997774124,
-0.22740362584590912,
-0.05817978084087372,
-0.1499093770980835,
-0.13984930515289307,
-0.07954494655132294,
-0.2357317954301834,
0.048367757350206375,
0.2681010365486145,
0.04715793579816818,
-0.05977350473403931,
0.0433284230530262,
0.052548717707395554,
0.03993791714310646,
-0.17540794610977173,
0.0336170457303524,
0.4104001522064209,
0.08065572381019592,
-0.03415825590491295,
-0.20573575794696808,
0.06304150819778442,
0.11528809368610382,
0.013953827321529388,
-0.009061661548912525,
0.06348905712366104,
0.0006114763673394918,
-0.0436595194041729,
-0.13528820872306824,
0.002531349193304777,
-0.2081279754638672,
-0.17289285361766815,
-0.059958238154649734,
-0.0029082256369292736,
0.06213913857936859,
-0.0965360775589943,
0.17675217986106873,
-0.03639925643801689,
0.06636696308851242,
-0.040352098643779755,
-0.1864943951368332,
0.060226745903491974,
-0.0003027596103493124,
0.09499766677618027,
-0.14527346193790436,
0.10013628751039505,
-0.1197250708937645,
-0.254576176404953,
0.2072019875049591,
0.20929645001888275,
-0.00544825941324234,
-0.08972032368183136,
-0.07437869906425476,
-0.17700587213039398,
-0.2529621422290802,
0.09738539159297943,
-0.0699375569820404,
0.13939452171325684,
0.05533377826213837,
0.08658895641565323,
-0.1513095200061798,
0.04421968013048172,
-0.06046245992183685,
-0.06099710986018181,
-0.05740610137581825,
0.24815689027309418,
0.07496123015880585,
0.019120898097753525,
-0.20130254328250885,
-0.11203090846538544,
-0.043949805200099945,
0.0761566162109375,
0.05518290027976036,
0.09314144402742386,
-0.004799104295670986,
-0.18331821262836456,
-0.14285852015018463,
-0.1819271594285965,
-0.04945113882422447,
-0.017225515097379684,
-0.010508999228477478,
-0.06450636684894562,
-0.09340021014213562,
-0.13779708743095398,
0.05381838232278824,
-0.05937689542770386,
0.1782582402229309,
0.04845427721738815,
0.09513435512781143
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. variants in genes that do not explain the underlying phenotype. (3) Methods used in a panel may include sequence analysis, deletion/duplication analysis, and/or other non-sequencing-based tests.For an introduction to multigene panels click here. More detailed information for clinicians ordering genetic tests can be found here.More comprehensive genomic testing (when available) including exome sequencing and genome sequencing may be considered. Such testing may provide or suggest a diagnosis not previously considered (e.g., a variant in a different gene or genes that results in a similar clinical presentation).For an introduction to comprehensive genomic testing click here. More detailed information for clinicians ordering genomic testing can be found here.Note: The methodology used for testing must be designed to detect mosaic variants: that is, variants at a less than 50% allelic level. Some individuals with PS have had variant allele frequencies below 1%, which can be challenging (or impossible) to detect with some assay techniques.Table | [
-0.0057783885858953,
0.009097310714423656,
-0.08546215295791626,
-0.26665952801704407,
-0.022776838392019272,
-0.21911294758319855,
0.13236895203590393,
-0.09377536177635193,
-0.0701313242316246,
-0.0294642336666584,
0.2133583277463913,
0.007877140305936337,
-0.0644809827208519,
0.0038581376429647207,
-0.1431192308664322,
0.0626244843006134,
0.1170351579785347,
0.014517329633235931,
-0.011267832480370998,
0.13908107578754425,
0.06853899359703064,
-0.06976067274808884,
-0.10787734389305115,
0.12783114612102509,
0.17537067830562592,
-0.1294395923614502,
0.18088994920253754,
0.1275404840707779,
-0.03114922158420086,
-0.0050142970867455006,
-0.08587124943733215,
-0.02881687693297863,
-0.0736401155591011,
-0.2303904891014099,
-0.03557746112346649,
-0.2889646887779236,
-0.143827423453331,
0.1162673607468605,
0.13005447387695312,
-0.08123159408569336,
0.07014060020446777,
0.07191800326108932,
0.10498388856649399,
-0.06559867411851883,
0.14740191400051117,
-0.08618239313364029,
0.08184604346752167,
0.0809604749083519,
0.11124996840953827,
0.19006001949310303,
0.062066998332738876,
0.016439974308013916,
-0.027730565518140793,
0.007686644792556763,
0.16520123183727264,
0.0053234342485666275,
-0.025924773886799812,
-0.23088668286800385,
-0.32201334834098816,
-0.28069183230400085,
0.13123050332069397,
0.09988772124052048,
-0.048375021666288376,
-0.18694642186164856,
0.2937679588794708,
-0.15743312239646912,
0.07501376420259476,
0.019606642425060272,
0.14307352900505066,
-0.02939091995358467,
0.24461330473423004,
-0.1349402219057083,
0.14373333752155304,
-0.036489080637693405,
-0.06410759687423706,
0.04207364469766617,
0.06944327801465988,
-0.06393454223871231,
0.03558719903230667,
-0.35975712537765503,
-0.10066916048526764,
-0.18436837196350098,
0.19068026542663574,
0.17671693861484528,
-0.0998765304684639,
-0.12327183037996292,
-0.030067864805459976,
0.09387236088514328,
0.0006995824514888227,
0.23992431163787842,
-0.11485045403242111,
0.01894618570804596,
0.010312323458492756,
0.10105816274881363,
0.2368279993534088,
-0.11824040114879608,
0.13756678998470306,
-0.033492352813482285,
0.05536217242479324,
0.11812981963157654,
0.18430320918560028,
0.08270996063947678,
-0.15909093618392944,
-0.08996259421110153,
0.28513026237487793,
-0.05918487533926964,
-0.05518655478954315,
-0.0730409249663353,
-0.03715969994664192,
0.05455951765179634,
-0.114037424325943,
0.04258134216070175,
-0.004494607448577881,
-0.11662717163562775,
-0.18839377164840698,
-0.009858472272753716,
0.04059401899576187,
0.055328380316495895,
-0.07091191411018372,
-0.10305380821228027,
-0.006707234773784876,
-0.14752086997032166,
0.13401490449905396,
-0.15825246274471283,
-0.033493515104055405,
-0.003189164213836193,
0.2305992990732193,
-0.2681063413619995,
0.05142855644226074,
-0.10724383592605591,
0.1270330250263214,
0.1404465138912201,
0.10176858305931091,
-0.1262686550617218,
0.13220347464084625,
0.013810188509523869,
-0.02306969091296196,
-0.08051948994398117,
0.10493728518486023,
-0.06421645730733871,
0.16872277855873108,
0.22554925084114075,
0.26068055629730225,
-0.01951693929731846,
-0.027059679850935936,
0.0764460414648056,
0.10292385518550873,
-0.25478261709213257,
0.08429087698459625,
-0.07048768550157547,
0.2950339913368225,
-0.19618169963359833,
0.24785815179347992,
0.06358310580253601,
-0.028616197407245636,
-0.2003229707479477,
-0.1457017958164215,
0.12319602072238922,
-0.12955759465694427,
-0.023993998765945435,
-0.0012790234759449959,
-0.05324588343501091,
-0.08306851238012314,
-0.09806482493877411,
0.1820921003818512,
0.06174555420875549,
0.17915363609790802,
-0.06504622101783752,
0.19594037532806396,
0.02604670822620392,
-0.10784819722175598,
0.10460658371448517,
0.15746967494487762,
0.15191996097564697,
0.015182594768702984,
-0.028866056352853775,
0.1113242655992508,
0.1316724568605423,
-0.051383305341005325,
0.011790717951953411,
0.1196330115199089,
-0.05820338428020477,
-0.08443764597177505,
-0.13379259407520294,
-0.194221630692482,
-0.06559568643569946,
0.07368606328964233,
0.14213836193084717,
-0.1438748985528946,
0.138327494263649,
0.17525231838226318,
-0.10966145992279053,
-0.06694453209638596,
-0.1837780773639679,
-0.013422074727714062,
-0.23138661682605743,
-0.05797811970114708,
0.05779396370053291,
-0.05492906644940376,
-0.17997586727142334,
0.03072585165500641,
0.19567617774009705,
0.0062951585277915,
0.12028484791517258,
0.09083328396081924,
0.10974881052970886,
0.0632065013051033,
-0.0972043126821518,
-0.04575420543551445,
-0.0825480967760086,
0.21570034325122833,
0.14823749661445618,
-0.16790007054805756,
0.05330445617437363,
0.014907238073647022,
-0.13962534070014954,
0.05323377624154091,
-0.1607992798089981,
-0.04339098930358887,
0.22978860139846802,
-0.30716922879219055,
0.20303630828857422,
-0.079930379986763,
-0.18024685978889465,
-0.05266483500599861,
0.12929795682430267,
0.04946669191122055,
0.042755261063575745,
0.1231081634759903,
0.08320572227239609,
0.13424983620643616,
-0.037797462195158005,
-0.13851480185985565,
-0.032503243535757065,
-0.22124400734901428,
-0.2374545782804489,
0.009725759737193584,
0.0008091567433439195,
0.21503834426403046,
0.11877384036779404,
0.08551918715238571,
0.10326465219259262,
0.07449155300855637,
0.1607227772474289,
0.08680449426174164,
0.06043635681271553,
-0.02832905389368534,
-0.015716077759861946,
-0.19010955095291138,
0.032505255192518234,
-0.05291184410452843,
-0.034939251840114594,
0.15837708115577698,
-0.05805331841111183,
-0.16793103516101837,
-0.1871652603149414,
0.017178639769554138,
-0.049500856548547745,
0.1709478199481964,
0.024109868332743645,
0.05291741341352463,
0.08812045305967331,
0.09680003672838211,
0.07362381368875504,
-0.2375209927558899,
-0.0053496574983000755,
-0.1643095314502716,
0.012477554380893707,
-0.07858001440763474,
-0.1668470948934555,
-0.15692654252052307,
0.08304106444120407,
-0.012656445614993572,
0.031159615144133568,
0.05697184056043625,
0.1813662350177765,
0.11185295879840851,
0.1467779278755188,
0.08708769083023071,
0.09155038744211197,
-0.05011608451604843,
0.07744747400283813,
-0.038361478596925735,
-0.03954906016588211,
0.19684596359729767,
0.05455030873417854,
-0.2696496248245239,
0.27465084195137024,
0.022137396037578583,
0.0111604118719697,
0.03355715051293373,
0.20064352452754974,
0.0588076151907444,
0.07539576292037964,
0.1192958727478981,
0.23173746466636658,
0.10579331964254379,
0.02656881883740425,
0.06258010864257812,
-0.1689407229423523,
0.29183435440063477,
0.016734767705202103,
-0.17093974351882935,
-0.03009764477610588,
-0.13012751936912537,
0.005745443049818277,
0.1977611780166626,
-0.030779512599110603,
0.11130208522081375,
-0.056268543004989624,
-0.24990089237689972,
-0.057395778596401215,
-0.10352551192045212,
0.07683931291103363,
0.03714588284492493,
0.05426692217588425,
-0.06766894459724426,
0.17769543826580048,
0.1026710569858551,
0.17393897473812103,
0.029212087392807007,
0.13818727433681488,
0.2510301172733307,
0.050121963024139404,
0.05213174223899841,
0.007883241400122643,
-0.17543376982212067,
0.23115406930446625,
-0.052017804235219955,
0.09575764834880829,
0.05316944792866707,
0.03294576704502106,
-0.2074057012796402,
-0.17645306885242462,
0.10183224827051163,
0.09244649857282639,
0.13411153852939606,
0.0021389087196439505,
-0.04549308493733406,
0.0026790304109454155,
-0.037931010127067566,
-0.357602596282959,
0.06416114419698715,
0.11718608438968658,
0.029295243322849274,
0.10124603658914566,
0.007994204759597778,
-0.15145793557167053,
-0.04500669240951538,
-0.09653105586767197,
-0.1685590147972107,
-0.18709337711334229,
0.023575695231556892,
-0.19960179924964905,
0.3227117955684662,
-0.017327623441815376,
0.20067502558231354,
0.11918839067220688,
-0.062159981578588486,
-0.016855470836162567,
-0.0734465941786766,
-0.04191196709871292,
-0.03617985546588898,
0.028884489089250565,
-0.0003012948436662555,
-0.04468291625380516,
-0.037097860127687454,
0.09694348275661469,
0.2041948288679123,
0.07695604115724564,
0.17984236776828766,
-0.0042467680759727955,
0.02516440488398075,
-0.0541018545627594,
0.06609285622835159,
0.031928323209285736,
-0.059608764946460724,
0.13425183296203613,
-0.10123611241579056,
-0.1437176614999771,
-0.07952859997749329,
-0.005991308018565178,
0.034131962805986404,
-0.2008005678653717,
-0.04865526780486107,
0.32241880893707275,
-0.28036627173423767,
0.2002020925283432,
0.07587668299674988,
-0.1354055553674698,
0.2416488081216812,
-0.03466625511646271,
0.10989102721214294,
0.18421824276447296,
0.003205728018656373,
0.2397705465555191,
-0.034274227917194366,
-0.06142260879278183,
-0.06454942375421524,
-0.10211479663848877,
-0.10879866033792496,
-0.13607478141784668,
-0.013796450570225716,
0.19258785247802734,
0.011326340958476067,
-0.04277000203728676,
-0.06783898174762726,
0.01410742849111557,
-0.10929780453443527,
0.3251422345638275,
-0.03144029527902603,
0.07489647716283798,
-0.06081133708357811,
-0.051023371517658234,
0.06402910500764847,
0.03622066229581833,
-0.07978781312704086,
0.011082160286605358,
-0.006301770452409983,
-0.12448084354400635,
0.030410364270210266,
0.05417710915207863,
0.056447166949510574,
-0.04886459559202194,
-0.08867555111646652,
-0.007151230238378048,
-0.0969093069434166,
0.1764744371175766,
-0.13355278968811035,
0.08230070769786835,
0.23518584668636322,
0.008221758529543877,
-0.22089748084545135,
0.14270496368408203,
-0.05814775079488754,
0.10097609460353851,
0.08124005049467087,
-0.1827501505613327,
0.2001081258058548,
-0.0537845715880394,
0.20152822136878967,
-0.07562798261642456,
0.04057684168219566,
0.09443920105695724,
-0.07829543203115463,
0.044192954897880554,
-0.019003938883543015,
0.004922292660921812,
-0.02474861592054367,
0.1465865522623062,
-0.05866057425737381,
0.06622039526700974,
0.03410867601633072,
-0.09494978189468384,
0.13626375794410706,
0.09084977954626083,
-0.09675300121307373,
-0.06366962194442749,
-0.10804406553506851,
0.03398915007710457,
-0.15272396802902222,
0.036540109664201736,
0.11577195674180984,
-0.0620550774037838,
-0.07566925138235092,
-0.040134675800800323,
-0.1660851389169693,
-0.06832973659038544,
0.16601131856441498,
-0.05014823377132416,
0.10367204248905182,
-0.07080966979265213,
0.13286927342414856,
-0.018343761563301086,
-0.004381628707051277,
-0.01547329407185316,
0.003559472970664501,
0.015642553567886353,
0.031251419335603714,
-0.0031715964432805777,
0.025803986936807632,
0.04393891617655754,
-0.06358422338962555,
-0.18962612748146057,
-0.007762246765196323,
0.20550072193145752,
0.0053523532114923,
-0.136942058801651,
-0.1288391500711441,
-0.22107604146003723,
0.07766787707805634,
0.14496250450611115,
0.011395671404898167,
0.20799484848976135,
-0.03617358207702637,
-0.25323835015296936,
0.13799937069416046,
-0.07249342650175095,
-0.18728399276733398,
-0.08170638978481293,
0.08889594674110413,
0.23622585833072662,
0.10001151263713837,
0.007250414229929447,
-0.07017935067415237,
-0.0932074710726738,
-0.059186872094869614,
-0.16390635073184967,
-0.17151735723018646,
0.10160711407661438,
-0.192689910531044,
0.011669684201478958,
0.13325341045856476,
-0.091574527323246,
-0.1384352445602417,
0.07100420445203781,
-0.093360036611557,
-0.057937365025281906,
0.04155226796865463,
0.017723754048347473,
-0.1476338803768158,
-0.06006481871008873,
0.11115418374538422,
0.0651196837425232,
-0.013339278288185596,
-0.14648878574371338,
-0.013258603401482105,
0.13194872438907623,
0.03654063493013382,
-0.11174102127552032,
-0.20402592420578003,
0.03634800761938095,
-0.049310095608234406,
0.018655765801668167,
0.3162906765937805,
0.21684861183166504,
-0.055344223976135254,
-0.10533986240625381,
-0.38683149218559265,
0.10635780543088913,
-0.16517576575279236,
-0.03664419800043106,
0.32561108469963074,
0.04886661097407341,
0.09826812148094177,
-0.11913063377141953,
0.06976224482059479,
0.1610986888408661,
0.28088971972465515,
0.2205912321805954,
-0.021823357790708542,
-0.021087244153022766,
-0.043215107172727585,
-0.0030387400183826685,
-0.22974716126918793,
-0.07978320121765137,
0.11029676347970963,
-0.0062876613810658455,
0.08192058652639389,
0.11550550162792206,
-0.0409795381128788,
0.0516185499727726,
0.13678711652755737,
0.048416800796985626,
0.12088488042354584,
0.17141050100326538,
0.032687295228242874,
0.11288177222013474,
0.07920452207326889,
0.09512259811162949,
-0.10539239645004272,
-0.049158643931150436,
0.16223396360874176,
-0.015340743586421013,
-0.08290094137191772,
0.15020684897899628,
-0.1128358542919159,
-0.014999466016888618,
-0.24038618803024292,
0.07178917527198792,
0.06408929824829102,
-0.25121352076530457,
-0.119179368019104,
-0.16883063316345215,
-0.07065955549478531,
0.03917313367128372,
-0.151031494140625,
0.05397035554051399,
0.27213239669799805,
0.06981726735830307,
-0.12425507605075836,
-0.18258310854434967,
0.16144417226314545,
0.05294325202703476,
-0.08550826460123062,
0.039916686713695526,
0.3100871443748474,
0.12562742829322815,
0.04514988511800766,
-0.00955915730446577,
-0.09910758584737778,
0.13870316743850708,
-0.16264569759368896,
-0.1803392767906189,
-0.021438615396618843,
0.08606338500976562,
-0.05386042967438698,
-0.23403975367546082,
0.20003367960453033,
0.06529754400253296,
-0.04295744374394417,
-0.1539512723684311,
-0.07789497077465057,
-0.010101020336151123,
0.2793782651424408,
-0.139365091919899,
0.17686012387275696,
-0.014687774702906609,
0.3328511118888855,
0.026426667347550392,
0.30678805708885193,
-0.15089286863803864,
0.08266833424568176,
-0.24165484309196472,
0.008026942610740662,
0.22739645838737488,
-0.08607421815395355,
-0.13785472512245178,
0.08682400733232498,
-0.013636806048452854,
0.08936894685029984,
0.040022362023591995,
0.051815327256917953,
0.03349333629012108,
0.04010530561208725,
0.1761508285999298,
-0.0415600948035717,
-0.21042156219482422,
-0.06635142117738724,
-0.07575781643390656,
-0.11794059723615646,
-0.03174643591046333,
-0.1404445916414261,
0.10050785541534424,
-0.20673508942127228,
0.0055307322181761265,
0.08658672124147415,
-0.1642588973045349,
-0.15379023551940918,
-0.07574833184480667,
0.005558536387979984,
0.20195913314819336,
0.09254782646894455,
0.011119235306978226,
0.23121298849582672,
-0.19060976803302765,
0.3359459936618805,
0.1409752368927002,
0.02283639647066593,
-0.1189841479063034,
-0.01915588788688183,
-0.04214739799499512,
-0.03135402128100395,
0.09483278542757034,
0.05176406726241112,
0.03824364393949509,
-0.050830140709877014,
0.021779021248221397,
-0.1368127316236496,
-0.19479979574680328,
-0.2950001358985901,
0.010110488161444664,
0.07463810592889786,
0.03890257328748703,
-0.11130799353122711,
0.14619052410125732,
0.13915345072746277,
0.04430549591779709,
-0.00985176581889391,
0.18161478638648987,
-0.004818950314074755,
-0.40404295921325684,
-0.09248203039169312,
-0.12164457887411118,
-0.09526804834604263,
-0.006684341933578253,
-0.17694540321826935,
0.02997271716594696,
0.14637941122055054,
-0.018511388450860977,
-0.11863131821155548,
0.006737798452377319,
0.045175950974226,
0.02841123193502426,
-0.12909922003746033,
0.08414386212825775,
0.4811045825481415,
0.10157443583011627,
-0.05437428876757622,
-0.16213345527648926,
0.022199338302016258,
-0.06443946063518524,
-0.04020456597208977,
0.002443986013531685,
0.03349626064300537,
-0.14041352272033691,
0.042906492948532104,
-0.08314061909914017,
0.02246256172657013,
-0.2910207509994507,
-0.10763468593358994,
-0.08108513802289963,
0.1088174432516098,
0.031643565744161606,
-0.08903896808624268,
0.22169987857341766,
-0.057646799832582474,
0.16466209292411804,
-0.09291882067918777,
-0.07560357451438904,
-0.0709405243396759,
0.06903503090143204,
0.012146322056651115,
-0.17849110066890717,
0.1287831813097,
-0.10038953274488449,
-0.21425260603427887,
0.1397683024406433,
0.18431556224822998,
0.10041505843400955,
-0.07005741447210312,
-0.04980443790555,
-0.18631446361541748,
-0.11944425106048584,
0.04832734540104866,
0.13773366808891296,
0.1274900883436203,
0.14037419855594635,
0.03145387023687363,
-0.21871785819530487,
-0.00648094667121768,
-0.10319077968597412,
-0.07868880778551102,
-0.009058324620127678,
0.22551202774047852,
0.007718944922089577,
-0.10918153822422028,
-0.1422645002603531,
-0.07242029905319214,
-0.08082575350999832,
0.11778196692466736,
0.024405717849731445,
-0.021378351375460625,
-0.03809080645442009,
-0.10963843017816544,
-0.15063020586967468,
-0.15233571827411652,
-0.1266515552997589,
0.023846009746193886,
-0.0262137483805418,
0.017939750105142593,
-0.10935647785663605,
-0.09960027039051056,
0.09275975078344345,
-0.1211632490158081,
0.14451894164085388,
0.13529744744300842,
-0.0347321592271328
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. g., a variant in a different gene or genes that results in a similar clinical presentation).For an introduction to comprehensive genomic testing click here. More detailed information for clinicians ordering genomic testing can be found here.Note: The methodology used for testing must be designed to detect mosaic variants: that is, variants at a less than 50% allelic level. Some individuals with PS have had variant allele frequencies below 1%, which can be challenging (or impossible) to detect with some assay techniques.Table 1. Molecular Genetic Testing Used in Proteus SyndromeView in own windowGene 1Test MethodProportion of Probands with a Pathogenic Variant 2 Detectable by This MethodAKT1Targeted analysis33/70 3, 4Sequence analysis 4See footnote 5Gene-targeted deletion/duplication analysis 6Unknown 71. See Table A. Genes and Databases for chromosome locus and protein.2. See Molecular Genetics for information on allelic variants detected in this gene.3 | [
-0.010404999367892742,
0.010837558656930923,
-0.09908445179462433,
-0.2464400827884674,
-0.05192628130316734,
-0.18151161074638367,
0.08739582449197769,
-0.05583819001913071,
-0.18203996121883392,
-0.05257505923509598,
0.1984517127275467,
-0.02700802870094776,
-0.0582025945186615,
-0.06554514914751053,
-0.07052066922187805,
0.012983257882297039,
-0.008736122399568558,
0.12053821235895157,
-0.040561992675065994,
0.06885513663291931,
-0.0372418612241745,
-0.08614297211170197,
-0.0541091188788414,
0.21951374411582947,
0.1694653183221817,
-0.02827564999461174,
0.23851248621940613,
0.12361415475606918,
-0.035523366183042526,
-0.05819801613688469,
-0.016059178858995438,
0.05024518072605133,
0.006160368677228689,
-0.24547079205513,
0.0256352536380291,
-0.2870320677757263,
-0.2615654766559601,
0.05192013457417488,
0.2442408800125122,
-0.07559307664632797,
0.12031832337379456,
-0.012229697778820992,
0.006738197989761829,
0.08683229237794876,
0.12829190492630005,
-0.1870313435792923,
0.11102445423603058,
0.14065150916576385,
0.09375444054603577,
0.17832553386688232,
0.024579156190156937,
-0.0516296923160553,
0.03800974786281586,
0.009072236716747284,
0.1400977373123169,
0.04605957493185997,
-0.10105913877487183,
-0.17979340255260468,
-0.22156323492527008,
-0.40944552421569824,
0.10347428917884827,
0.15011730790138245,
0.029939597472548485,
-0.23772335052490234,
0.3400321304798126,
-0.0903657004237175,
0.11692576110363007,
-0.0308382548391819,
0.1816868633031845,
-0.029068317264318466,
0.22718492150306702,
-0.11660659313201904,
0.1116706132888794,
0.04416273161768913,
-0.07252205908298492,
0.0484253354370594,
0.10158108174800873,
0.01626840978860855,
0.0030513822566717863,
-0.21388566493988037,
-0.14028649032115936,
-0.1728571206331253,
0.23676227033138275,
0.32432541251182556,
-0.10546576976776123,
-0.15179015696048737,
-0.04539603739976883,
0.07450073957443237,
-0.017181213945150375,
0.21094848215579987,
-0.1079268828034401,
0.04552897810935974,
0.018436821177601814,
0.03928916156291962,
0.26884305477142334,
-0.12478435784578323,
-0.03868776559829712,
-0.05390369892120361,
0.01725136861205101,
0.06057391315698624,
0.1712503284215927,
0.08472783118486404,
-0.28841060400009155,
-0.022617153823375702,
0.2819252908229828,
-0.06187418848276138,
-0.06483101844787598,
-0.07959236204624176,
-0.0054558999836444855,
0.07352515310049057,
-0.123928964138031,
-0.11255137622356415,
0.05760938301682472,
-0.09137309342622757,
-0.20199142396450043,
0.029630733653903008,
0.053084395825862885,
0.042370401322841644,
-0.0886736810207367,
-0.06987147033214569,
-0.0019963677041232586,
-0.13403800129890442,
0.18122407793998718,
-0.13440535962581635,
-0.08910143375396729,
-0.07990007102489471,
0.09892697632312775,
-0.14944107830524445,
0.11780713498592377,
-0.18223297595977783,
0.17096151411533356,
0.08697354048490524,
0.058888956904411316,
-0.03089914843440056,
0.10895515978336334,
-0.0407714918255806,
-0.015162269584834576,
-0.07668516039848328,
0.07222247123718262,
-0.10860881954431534,
0.16856218874454498,
0.18682080507278442,
0.19755332171916962,
0.011165285483002663,
0.08724717795848846,
-0.016688454896211624,
0.13576467335224152,
-0.2235019952058792,
0.12905536592006683,
0.0018283305689692497,
0.24937213957309723,
-0.17659097909927368,
0.26550137996673584,
-0.0025351704098284245,
-0.02757844887673855,
-0.11725452542304993,
-0.16967029869556427,
0.04883672669529915,
-0.08861500024795532,
-0.0005565437022596598,
-0.11276841908693314,
-0.0627804696559906,
-0.094236820936203,
-0.17317554354667664,
0.19258111715316772,
0.006686207838356495,
0.21127279102802277,
-0.04452001303434372,
0.1663472056388855,
0.044099435210227966,
-0.053633276373147964,
0.08913678675889969,
0.0569937489926815,
0.12018026411533356,
0.03611817955970764,
-0.11068800836801529,
0.07141706347465515,
0.1256808042526245,
-0.03387698903679848,
-0.03279903903603554,
0.1868869513273239,
-0.07302451878786087,
-0.05000321939587593,
-0.12267468869686127,
-0.23114874958992004,
-0.06514838337898254,
0.16464878618717194,
0.16998794674873352,
-0.15487875044345856,
0.1924537569284439,
0.15866030752658844,
-0.09183190762996674,
-0.09510089457035065,
-0.20192280411720276,
0.027530835941433907,
-0.26228317618370056,
-0.0956854522228241,
0.021008402109146118,
0.025554437190294266,
-0.09631664305925369,
0.005851552821695805,
0.3668307662010193,
-0.03946471959352493,
0.14838939905166626,
0.12184080481529236,
0.11536022275686264,
0.03670841082930565,
0.0010667747119441628,
-0.10308912396430969,
-0.014086536131799221,
0.23849500715732574,
0.15601402521133423,
-0.18693296611309052,
-0.01863006502389908,
-0.04121462255716324,
-0.10020197927951813,
0.12214832007884979,
-0.20143632590770721,
-0.06360532343387604,
0.08488120883703232,
-0.3364274799823761,
0.1993446946144104,
-0.1429985612630844,
-0.24739430844783783,
0.025465264916419983,
0.09908967465162277,
0.06120234355330467,
0.037777967751026154,
0.06020517647266388,
0.10703086853027344,
0.19790568947792053,
-0.016799023374915123,
-0.18383574485778809,
-0.11362891644239426,
-0.22893746197223663,
-0.17490774393081665,
0.06713325530290604,
-0.13591325283050537,
0.1465727537870407,
0.07567448168992996,
0.05071152001619339,
0.04873420670628548,
0.07284896820783615,
0.12793183326721191,
0.09907431155443192,
-0.12004197388887405,
-0.031204035505652428,
-0.08203673362731934,
-0.20733684301376343,
0.0209368783980608,
-0.021582314744591713,
-0.1315310150384903,
0.20781776309013367,
-0.08032913506031036,
-0.1482863873243332,
-0.1674838811159134,
0.07350923120975494,
0.06721947342157364,
0.17777925729751587,
0.06262220442295074,
0.018476007506251335,
0.13965684175491333,
0.007646031677722931,
0.10907278954982758,
-0.22220711410045624,
0.040063802152872086,
-0.15890133380889893,
-0.011234031990170479,
-0.10150429606437683,
-0.167397141456604,
-0.22861161828041077,
0.13613809645175934,
-0.025795791298151016,
-0.017128130421042442,
0.07586222887039185,
0.1508420705795288,
0.15873681008815765,
0.17067338526248932,
0.01879030652344227,
0.11740519851446152,
0.039365705102682114,
0.07622504234313965,
0.027949567884206772,
0.0032142256386578083,
0.22262358665466309,
0.004744579549878836,
-0.12002615630626678,
0.2332082837820053,
-0.05172513425350189,
0.11053386330604553,
0.010217471979558468,
0.19479861855506897,
0.12266726046800613,
0.08376912772655487,
0.10169225186109543,
0.23386839032173157,
0.09042515605688095,
0.09252431988716125,
0.1355871856212616,
-0.11755093932151794,
0.27928492426872253,
0.013686902821063995,
-0.12323839962482452,
-0.004701521247625351,
-0.16817468404769897,
0.0709332674741745,
0.19464892148971558,
0.07085192203521729,
0.06592775881290436,
-0.1113998144865036,
-0.26123329997062683,
-0.0630897805094719,
-0.08862932026386261,
0.07435779273509979,
-0.044481389224529266,
0.13522565364837646,
0.003366753924638033,
0.19546832144260406,
0.020266776904463768,
0.22722747921943665,
0.10057466477155685,
0.15846529603004456,
0.1946786642074585,
0.11881028860807419,
0.10810014605522156,
0.011811000294983387,
-0.19381040334701538,
0.24207629263401031,
-0.0019580426160246134,
0.1949353665113449,
0.18057386577129364,
0.008548242971301079,
-0.13919439911842346,
-0.2050659954547882,
0.009175869636237621,
0.13346895575523376,
0.17298562824726105,
0.08194073289632797,
-0.05510503426194191,
0.014660710468888283,
-0.025496473535895348,
-0.3273937404155731,
0.04226129129528999,
0.08791237324476242,
-0.042637892067432404,
0.00503949960693717,
-0.11442162841558456,
-0.2013518065214157,
0.045982081443071365,
-0.10065510123968124,
-0.13495348393917084,
-0.07204356789588928,
0.028121409937739372,
-0.15066072344779968,
0.27997440099716187,
-0.12552835047245026,
0.2466740608215332,
0.09589420258998871,
-0.09239398688077927,
-0.0808698982000351,
-0.07487878203392029,
-0.054628435522317886,
-0.11338624358177185,
-0.02314012497663498,
-0.02115861140191555,
-0.023131268098950386,
-0.12951579689979553,
0.04111521318554878,
0.10853289812803268,
0.032371778041124344,
0.09150450676679611,
0.008527408353984356,
-0.02286890707910061,
-0.007254626136273146,
0.0250843595713377,
0.03512325882911682,
0.0745791345834732,
0.10838129371404648,
-0.07193713635206223,
-0.1357603818178177,
0.004291192162781954,
0.12043649703264236,
0.07318785786628723,
-0.14338520169258118,
-0.07635794579982758,
0.17876307666301727,
-0.3498738408088684,
0.2513345181941986,
0.056587669998407364,
-0.11718117445707321,
0.24826960265636444,
-0.08233968168497086,
0.13846710324287415,
0.26230213046073914,
-0.028043800964951515,
0.20301926136016846,
-0.09670194983482361,
-0.03096904419362545,
-0.00021678612392861396,
-0.044579192996025085,
-0.10121676325798035,
-0.1768931895494461,
-0.06625556945800781,
0.12176790833473206,
0.15132556855678558,
0.023082632571458817,
-0.07036963850259781,
-0.027639465406537056,
-0.1125498116016388,
0.36425232887268066,
-0.00514596002176404,
0.12297854572534561,
-0.12577570974826813,
-0.07926808297634125,
0.07698475569486618,
0.10565080493688583,
-0.03510237857699394,
0.029892411082983017,
0.028294185176491737,
-0.04588508605957031,
0.05204135552048683,
0.014172729104757309,
0.005451575852930546,
-0.0362887941300869,
-0.027957547456026077,
-0.09995745867490768,
-0.04840632155537605,
0.23768402636051178,
-0.10750547051429749,
0.06394602358341217,
0.16796426475048065,
0.021982824429869652,
-0.13832780718803406,
-0.03396396338939667,
-0.14932146668434143,
0.02278848923742771,
-0.03283118084073067,
-0.209307461977005,
0.1860334873199463,
0.004085782449692488,
0.21427355706691742,
-0.03729266673326492,
0.04888296499848366,
0.07809708267450333,
-0.14170296490192413,
0.07095508277416229,
-0.021907810121774673,
0.023012833669781685,
-0.012824924662709236,
0.22273769974708557,
-0.007070532068610191,
0.04475162923336029,
0.08652803301811218,
-0.11525655537843704,
0.11514125764369965,
0.07884658128023148,
-0.11417417228221893,
0.06373488157987595,
-0.14770208299160004,
0.05708817020058632,
-0.16166700422763824,
0.1025695651769638,
0.16866718232631683,
-0.13787008821964264,
-0.013588108122348785,
-0.14730380475521088,
-0.1487901657819748,
-0.18516972661018372,
0.16311679780483246,
-0.1493777632713318,
0.060845114290714264,
-0.07257796078920364,
0.1698000282049179,
-0.1570012867450714,
0.0922793447971344,
-0.06035961955785751,
-0.08203474432229996,
0.015083110891282558,
0.04513898864388466,
-0.03980637341737747,
0.11706656217575073,
0.05684400722384453,
0.03134509176015854,
-0.28788575530052185,
0.05563417449593544,
0.17189763486385345,
-0.0191828403621912,
-0.20310282707214355,
-0.07348250597715378,
-0.12130676209926605,
-0.008906801231205463,
0.10658981651067734,
0.08780886977910995,
0.16226068139076233,
-0.16067366302013397,
-0.1785907745361328,
0.11008915305137634,
0.012705434113740921,
-0.15109826624393463,
-0.039398614317178726,
0.1416293829679489,
0.12233973294496536,
0.1098867803812027,
-0.05634032562375069,
-0.037139154970645905,
-0.01016516424715519,
-0.040050260722637177,
-0.2900036573410034,
-0.1729905754327774,
0.13268716633319855,
-0.11808176338672638,
0.02244814857840538,
0.15512047708034515,
-0.036584507673978806,
0.002191852079704404,
0.036621592938899994,
-0.16002324223518372,
-0.08373714983463287,
-0.02691255696117878,
-0.13670632243156433,
-0.1720195859670639,
-0.15636229515075684,
0.07940133661031723,
0.05689403414726257,
-0.024944396689534187,
-0.11931230872869492,
-0.02139446884393692,
0.10834948718547821,
-0.024987859651446342,
-0.09487868845462799,
-0.2037135660648346,
0.08469255268573761,
-0.1425810009241104,
-0.025018442422151566,
0.26982393860816956,
0.12177301198244095,
-0.03152608126401901,
0.04607425257563591,
-0.36505988240242004,
0.07490718364715576,
-0.1600269228219986,
-0.11837536096572876,
0.3003445863723755,
0.10425104945898056,
0.10412268340587616,
-0.04933406412601471,
0.07437857985496521,
0.11677040159702301,
0.33468538522720337,
0.226671501994133,
0.010694130323827267,
-0.11352792382240295,
-0.16513995826244354,
-0.15520043671131134,
-0.3672724664211273,
-0.03192424774169922,
0.06355797499418259,
0.016560129821300507,
0.14149411022663116,
0.13474798202514648,
-0.11153141409158707,
-0.0318794772028923,
0.19332274794578552,
0.13831402361392975,
0.1621319055557251,
0.26195213198661804,
0.017900627106428146,
0.04414905607700348,
0.07410024851560593,
-0.11280184239149094,
-0.19931063055992126,
-0.09917157143354416,
0.2513488531112671,
0.0875978171825409,
-0.06379657238721848,
0.09030486643314362,
-0.22303663194179535,
-0.02070831134915352,
-0.3287540674209595,
0.09614644199609756,
0.05243244394659996,
-0.22635899484157562,
-0.2212899625301361,
-0.1713891625404358,
-0.1474359631538391,
0.020051004365086555,
-0.08162446320056915,
0.02101629227399826,
0.391541063785553,
0.07706792652606964,
-0.05979698896408081,
-0.22701211273670197,
0.03772253543138504,
0.04593818262219429,
-0.15825587511062622,
0.013128872029483318,
0.24917910993099213,
0.1504134237766266,
0.1432962417602539,
0.05608871951699257,
-0.1457233428955078,
0.07527752220630646,
-0.1347925215959549,
-0.18506629765033722,
-0.059688881039619446,
-0.0012346765724942088,
-0.05231473967432976,
-0.2361983358860016,
0.16578714549541473,
0.07548200339078903,
0.11123503744602203,
-0.16403907537460327,
-0.07527673989534378,
-0.01806718483567238,
0.33936959505081177,
-0.03223830834031105,
0.15821339190006256,
0.02466394379734993,
0.3700500428676605,
0.02093392424285412,
0.31022143363952637,
-0.10230440646409988,
0.1015876904129982,
-0.30079135298728943,
0.04510834440588951,
0.24855880439281464,
-0.1573224663734436,
-0.1750209480524063,
0.06691983342170715,
0.02787952311336994,
0.09786500781774521,
-0.0044975136406719685,
0.07758566737174988,
0.1555464267730713,
-0.0008247262449003756,
0.0916847437620163,
-0.028888292610645294,
-0.20892493426799774,
-0.044924162328243256,
-0.1060623750090599,
-0.12929485738277435,
-0.044649332761764526,
-0.026138851419091225,
0.06683236360549927,
-0.29490959644317627,
0.03768634796142578,
0.041548941284418106,
-0.08184046298265457,
-0.14471369981765747,
0.045450013130903244,
0.05596557632088661,
0.14537596702575684,
-0.00826549157500267,
0.11114432662725449,
0.20723949372768402,
-0.23689822852611542,
0.19703906774520874,
0.07753245532512665,
-0.02887626551091671,
-0.14018620550632477,
-0.01012161560356617,
-0.024416150525212288,
-0.026611175388097763,
0.09317376464605331,
-0.019658250734210014,
0.04132002964615822,
-0.0037215121556073427,
-0.03292880207300186,
-0.016857974231243134,
-0.2424611747264862,
-0.25098440051078796,
-0.04280493035912514,
0.10262419283390045,
0.0387192964553833,
-0.11584196984767914,
0.21789394319057465,
0.07829535007476807,
-0.011909589171409607,
-0.025249484926462173,
0.2881803810596466,
-0.13319462537765503,
-0.38834044337272644,
-0.14432393014431,
-0.030484363436698914,
-0.028440669178962708,
0.04680201783776283,
-0.1798391342163086,
0.10562555491924286,
0.12584838271141052,
-0.04258611798286438,
-0.13673025369644165,
0.08313927799463272,
0.02642141655087471,
0.041291963309049606,
-0.15275435149669647,
0.05931251496076584,
0.5376921892166138,
0.18837368488311768,
-0.09563451260328293,
-0.034517187625169754,
-0.1234835684299469,
-0.016829360276460648,
0.017412422224879265,
-0.04907321557402611,
0.05495566129684448,
-0.15723566710948944,
0.06194283813238144,
-0.08545717597007751,
-0.05238448828458786,
-0.3046993911266327,
-0.034823108464479446,
-0.1516549289226532,
0.2391451597213745,
0.07108275592327118,
-0.05764245614409447,
0.2081167846918106,
-0.01928536593914032,
0.13425563275814056,
-0.13331840932369232,
0.0535697340965271,
-0.027860047295689583,
0.005768641829490662,
-0.010486267507076263,
-0.12699216604232788,
0.19742682576179504,
-0.028291121125221252,
-0.1870400458574295,
0.10220642387866974,
0.15827523171901703,
0.12897133827209473,
-0.0639084130525589,
0.011704374104738235,
-0.11732999980449677,
0.04252001643180847,
0.05492102727293968,
0.25421032309532166,
0.10022399574518204,
0.026301264762878418,
0.060082968324422836,
-0.2356194257736206,
0.06916848570108414,
0.03451835364103317,
-0.18847036361694336,
-0.035299234092235565,
0.2778491973876953,
-0.04763362184166908,
-0.11571645736694336,
-0.10514567047357559,
-0.12330804765224457,
-0.07391747087240219,
0.12719294428825378,
0.06468364596366882,
-0.06239784508943558,
-0.01148085668683052,
-0.05787190422415733,
-0.13168379664421082,
-0.11246221512556076,
-0.10324100404977798,
-0.05367777869105339,
0.00513280788436532,
-0.026289507746696472,
-0.010956655256450176,
-0.030666135251522064,
0.14267946779727936,
-0.10911828279495239,
0.13403697311878204,
0.20767220854759216,
-0.10747548192739487
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. some assay techniques.Table 1. Molecular Genetic Testing Used in Proteus SyndromeView in own windowGene 1Test MethodProportion of Probands with a Pathogenic Variant 2 Detectable by This MethodAKT1Targeted analysis33/70 3, 4Sequence analysis 4See footnote 5Gene-targeted deletion/duplication analysis 6Unknown 71. See Table A. Genes and Databases for chromosome locus and protein.2. See Molecular Genetics for information on allelic variants detected in this gene.3. Somatic mosaicism for the AKT1 c.49G>A variant is the only pathogenic variant identified to date in individuals with clinically confirmed PS .4. The c.49G>A variant can be detected by sequence analysis of the surrounding region. Sequence analysis detects variants that are benign, likely benign, of uncertain significance, likely pathogenic, or pathogenic. Pathogenic variants may include small intragenic deletions/insertions and missense, nonsense, and splice site variants; | [
-0.08002530783414841,
-0.03512611612677574,
-0.05235495790839195,
-0.14058302342891693,
0.12211247533559799,
-0.008704044856131077,
0.048461124300956726,
-0.25808581709861755,
-0.05754290148615837,
-0.06577809900045395,
0.16561594605445862,
-0.061216577887535095,
-0.11822544783353806,
0.08796786516904831,
-0.07008529454469681,
0.26482418179512024,
-0.061437129974365234,
0.2161283940076828,
0.06857899576425552,
0.13794651627540588,
0.020690487697720528,
-0.2689345180988312,
0.08051833510398865,
0.09434053301811218,
0.09162303805351257,
-0.15562447905540466,
0.2998775541782379,
0.03534715995192528,
-0.09177488088607788,
-0.1512703150510788,
0.13756288588047028,
0.039126671850681305,
-0.1019691601395607,
-0.11273394525051117,
-0.10004100203514099,
-0.36933037638664246,
-0.18988071382045746,
0.06711375713348389,
0.17126153409481049,
-0.06212813779711723,
0.12804782390594482,
-0.03366267308592796,
0.04265938699245453,
-0.057108256965875626,
0.15063326060771942,
-0.17392897605895996,
0.13024063408374786,
0.1174846813082695,
0.12059170752763748,
0.24814429879188538,
0.11418509483337402,
0.08996761590242386,
0.05426863208413124,
-0.12920255959033966,
0.03306882828474045,
0.05321729555726051,
0.08863070607185364,
-0.10408011078834534,
-0.2304883450269699,
-0.11894167959690094,
0.1317368894815445,
0.030628526583313942,
-0.0007818085141479969,
-0.3333970606327057,
0.18946492671966553,
0.009017854928970337,
-0.06604960560798645,
0.08878552913665771,
0.25578930974006653,
0.02154119685292244,
0.08729706704616547,
-0.07890044152736664,
0.021326357498764992,
-0.12222245335578918,
0.05105786398053169,
0.005284404847770929,
0.1991879642009735,
0.035427819937467575,
0.0424056276679039,
-0.2522384822368622,
-0.12813319265842438,
-0.13768693804740906,
-0.11952066421508789,
0.2996809780597687,
-0.11846961081027985,
-0.34149324893951416,
-0.06977434456348419,
-0.14061301946640015,
-0.08343343436717987,
0.2522290050983429,
-0.02697211503982544,
0.20786938071250916,
0.21683523058891296,
0.3442500829696655,
0.09743045270442963,
-0.010199621319770813,
0.017703952267766,
0.19052132964134216,
-0.11330049484968185,
0.03685574606060982,
-0.0026737593580037355,
0.1457042545080185,
-0.3412451446056366,
0.05667351186275482,
0.14175598323345184,
-0.09784822165966034,
0.044815290719270706,
-0.10084374994039536,
0.05912939831614494,
-0.05065762996673584,
-0.06730775535106659,
-0.13120293617248535,
-0.12250228226184845,
-0.10893809795379639,
-0.08125295490026474,
-0.19568027555942535,
-0.13829201459884644,
0.05758524686098099,
-0.193999245762825,
0.1589118242263794,
-0.02384764887392521,
-0.06912726908922195,
0.006467267405241728,
-0.048876840621232986,
-0.1788998246192932,
-0.12953969836235046,
0.12759625911712646,
-0.26277559995651245,
0.17325951159000397,
0.029831264168024063,
0.08698845654726028,
0.0019522123038768768,
0.07109095901250839,
-0.026735827326774597,
0.10499229282140732,
-0.17656129598617554,
-0.07158816605806351,
0.0081020537763834,
0.05700831487774849,
-0.02056843973696232,
0.2456163763999939,
0.17452362179756165,
0.3757038414478302,
0.029785726219415665,
-0.02316868118941784,
0.051831554621458054,
0.22719691693782806,
-0.05089369788765907,
-0.026653524488210678,
-0.05278311297297478,
0.0483853705227375,
-0.12318105250597,
0.2852788269519806,
0.07133928686380386,
-0.09556577354669571,
-0.01974409446120262,
-0.05978378280997276,
0.18141783773899078,
-0.17191290855407715,
-0.04809395223855972,
-0.04941565543413162,
0.03362664580345154,
0.05233701691031456,
-0.13206230103969574,
0.31290143728256226,
0.1189802885055542,
-0.012746199034154415,
-0.10028532892465591,
0.11054043471813202,
0.00906312931329012,
-0.0896264836192131,
0.07757703959941864,
-0.09177649766206741,
0.07541967928409576,
0.04428543150424957,
0.01732029765844345,
-0.16344302892684937,
-0.06622350960969925,
0.05452502891421318,
-0.24415554106235504,
0.07012048363685608,
-0.03807297721505165,
-0.025864357128739357,
-0.09768693149089813,
-0.10936909168958664,
-0.13512161374092102,
0.06704914569854736,
0.16998977959156036,
-0.1369689404964447,
0.10675647854804993,
0.04902514070272446,
0.027447285130620003,
-0.15775460004806519,
-0.1795363575220108,
0.07225122302770615,
-0.15988382697105408,
-0.09366117417812347,
0.08948000520467758,
0.08096462488174438,
-0.2655895948410034,
-0.050809744745492935,
0.15990068018436432,
-0.10964285582304001,
-0.12782512605190277,
0.08267887681722641,
0.11369452625513077,
0.055149439722299576,
0.00965861789882183,
0.01248130016028881,
0.15713292360305786,
0.17668285965919495,
0.32358497381210327,
-0.055320363491773605,
-0.05781533941626549,
0.0006161081837490201,
-0.016462741419672966,
0.06805731356143951,
-0.19924256205558777,
0.11400625854730606,
0.18168696761131287,
-0.13244254887104034,
0.12409830838441849,
-0.05052753537893295,
-0.23875722289085388,
-0.13225100934505463,
0.07518786936998367,
-0.038605447858572006,
-0.02273654192686081,
-0.030506763607263565,
0.009165165014564991,
0.13831961154937744,
-0.17644314467906952,
0.028477445244789124,
-0.1485227793455124,
-0.11494190990924835,
-0.07571842521429062,
0.11732280999422073,
0.04772347956895828,
-0.08892250061035156,
0.10739517211914062,
-0.07769648730754852,
-0.07341799885034561,
0.006684199906885624,
-0.05196733772754669,
0.021554268896579742,
-0.08245739340782166,
0.138497993350029,
-0.020981188863515854,
-0.23900751769542694,
0.022493531927466393,
-0.1153172105550766,
-0.019435210153460503,
0.11667964607477188,
-0.06463532149791718,
-0.17919319868087769,
-0.11168259382247925,
-0.09257851541042328,
0.09251750260591507,
0.2318115532398224,
0.14368216693401337,
0.2372826337814331,
0.1371220350265503,
0.07130634039640427,
0.029326919466257095,
-0.2733027935028076,
0.06297076493501663,
-0.0892808809876442,
0.011754110455513,
-0.13045231997966766,
-0.039825793355703354,
-0.06022412329912186,
0.1651267260313034,
-0.09349341690540314,
0.05942181125283241,
-0.11328636854887009,
0.18351364135742188,
0.2683390974998474,
0.19278864562511444,
0.03295745328068733,
0.1778968870639801,
-0.03923062980175018,
0.007443132810294628,
-0.09302062541246414,
0.18022789061069489,
0.20137467980384827,
0.027529176324605942,
-0.17418627440929413,
-0.009813915006816387,
0.003971735015511513,
-0.02551177889108658,
-0.0549958236515522,
0.14951486885547638,
0.03827304020524025,
0.07494165003299713,
0.001807140070013702,
0.15373846888542175,
-0.10664808005094528,
0.036055371165275574,
-0.03175915777683258,
-0.12224212288856506,
0.1458975374698639,
0.18173062801361084,
0.044645264744758606,
-0.09180717170238495,
0.0960790142416954,
0.08180675655603409,
0.24994291365146637,
-0.07813381403684616,
0.18156927824020386,
-0.17852002382278442,
-0.23763211071491241,
0.14838860929012299,
-0.11493755877017975,
0.1483088731765747,
-0.1880624145269394,
0.16658081114292145,
0.1864972710609436,
-0.11574502289295197,
0.11355828493833542,
0.14444653689861298,
-0.15610919892787933,
0.15320689976215363,
0.15240898728370667,
0.07504232972860336,
0.018494151532649994,
-0.013521211221814156,
-0.16620038449764252,
0.12782278656959534,
0.009059264324605465,
0.10760688781738281,
0.25390803813934326,
0.006308493670076132,
-0.20711499452590942,
0.012340357527136803,
0.10427182167768478,
0.006809665821492672,
-0.004723203368484974,
-0.03594936430454254,
-0.2132660150527954,
-0.14791978895664215,
0.03654125705361366,
-0.12816749513149261,
-0.056035544723272324,
0.27458640933036804,
0.10616381466388702,
0.11035855114459991,
-0.05060049518942833,
0.008927981369197369,
-0.1708730310201645,
-0.06322651356458664,
-0.10582416504621506,
-0.11712216585874557,
0.10992216318845749,
-0.10288114845752716,
0.2732716202735901,
-0.1512150913476944,
0.18480198085308075,
0.1838318407535553,
-0.10514403134584427,
0.12186475098133087,
-0.05747377127408981,
-0.04969592019915581,
-0.10402625054121017,
-0.10236471891403198,
-0.10846807062625885,
-0.19083833694458008,
0.05025386065244675,
0.16176612675189972,
0.058793723583221436,
0.12873990833759308,
0.3779485821723938,
0.07776353508234024,
0.11214000731706619,
-0.04001927003264427,
0.024673715233802795,
0.11984103918075562,
-0.11890507489442825,
0.1409706175327301,
-0.06141640245914459,
-0.20630759000778198,
0.22784380614757538,
0.09414439648389816,
0.1250518262386322,
-0.1494913101196289,
-0.030557861551642418,
0.02054578624665737,
-0.18145281076431274,
-0.027922170236706734,
0.042239490896463394,
0.009084991179406643,
0.09206076711416245,
-0.07137387245893478,
0.04045623168349266,
0.027594439685344696,
0.07983426749706268,
-0.0023972901981323957,
0.08933791518211365,
-0.18476136028766632,
-0.1544850766658783,
-0.21182990074157715,
-0.0947444811463356,
-0.2584022283554077,
-0.06946662068367004,
0.07378306984901428,
-0.07191548496484756,
0.03657345846295357,
-0.04186389595270157,
0.06405782699584961,
0.0596473328769207,
0.3812573254108429,
-0.05679040402173996,
-0.015677256509661674,
-0.049176283180713654,
-0.004911317490041256,
-0.10422638058662415,
0.03955231234431267,
0.10518083721399307,
0.03785792365670204,
-0.03703559190034866,
-0.0409797765314579,
0.14889833331108093,
0.36391496658325195,
-0.013351203873753548,
-0.14202836155891418,
0.022449294105172157,
0.007905827835202217,
0.018163910135626793,
0.19310589134693146,
-0.026621026918292046,
0.1812446415424347,
0.22352994978427887,
0.03446714207530022,
-0.19082674384117126,
-0.07355566322803497,
-0.0451982282102108,
0.07639247179031372,
0.2704097330570221,
0.05430404841899872,
0.05578964948654175,
-0.06274396181106567,
0.16587723791599274,
0.08856639266014099,
0.07225405424833298,
0.0876515731215477,
-0.15491938591003418,
-0.07824712991714478,
0.010125366039574146,
0.15205292403697968,
-0.11793156713247299,
0.07493489235639572,
0.011314698494970798,
0.009746243245899677,
0.020631201565265656,
-0.11961601674556732,
0.10223183035850525,
0.04423733428120613,
0.0566902793943882,
0.010325388982892036,
-0.07510419934988022,
0.12140046060085297,
-0.28899386525154114,
-0.015075487084686756,
0.25326335430145264,
0.028996996581554413,
0.06052880361676216,
-0.0582757294178009,
0.00009047733328770846,
-0.049603525549173355,
0.15303504467010498,
-0.1321137249469757,
0.04519366845488548,
-0.08498605340719223,
0.1748238503932953,
-0.11253722757101059,
-0.003336341353133321,
-0.11247292160987854,
-0.037556953728199005,
0.03391353413462639,
-0.08480467647314072,
-0.05622827261686325,
0.30521097779273987,
-0.006021639332175255,
0.06302333623170853,
-0.10554592311382294,
0.06793135404586792,
0.20163336396217346,
0.02313780039548874,
-0.23051507771015167,
0.13846030831336975,
-0.05582714453339577,
-0.012941834516823292,
0.035406067967414856,
0.3437238037586212,
0.1858680695295334,
-0.12374239414930344,
-0.2142416536808014,
0.19591543078422546,
-0.1068544089794159,
-0.1466481238603592,
-0.07598567754030228,
0.07560103386640549,
0.24222975969314575,
0.247121199965477,
0.10129835456609726,
-0.11399295181035995,
-0.023918047547340393,
-0.07625019550323486,
-0.34086206555366516,
-0.1428174525499344,
0.04432870075106621,
-0.20071491599082947,
-0.11536385864019394,
0.1374431550502777,
-0.14176800847053528,
0.20393086969852448,
-0.11143657565116882,
-0.1982324719429016,
-0.13778206706047058,
-0.03419359028339386,
0.0024209977127611637,
-0.06540454179048538,
-0.2249099612236023,
0.051243603229522705,
0.051849815994501114,
-0.006735044065862894,
-0.1864001303911209,
-0.16155371069908142,
0.12257768213748932,
-0.21663792431354523,
0.14176729321479797,
-0.26628491282463074,
-0.027499737218022346,
-0.12453150749206543,
0.13169805705547333,
-0.046999406069517136,
0.16988205909729004,
0.04072948172688484,
0.17281731963157654,
-0.19338680803775787,
-0.03794225677847862,
-0.2542605996131897,
-0.11233195662498474,
0.15280476212501526,
0.1398848295211792,
0.06116520240902901,
0.028633257374167442,
0.2501583993434906,
0.024903999641537666,
0.3560769855976105,
0.22611649334430695,
0.06995119154453278,
-0.24763135612010956,
-0.03068290278315544,
-0.10807156562805176,
-0.31320488452911377,
0.17026108503341675,
0.06505920737981796,
-0.08277728408575058,
0.0036902145948261023,
0.3335582911968231,
0.05405344069004059,
-0.08786892890930176,
-0.0079664196819067,
0.0554131455719471,
0.20629152655601501,
0.19137175381183624,
0.156714528799057,
-0.1138632521033287,
0.0867094099521637,
-0.03603518009185791,
-0.11346838623285294,
-0.21477600932121277,
0.17212066054344177,
-0.03730805590748787,
-0.07956665009260178,
-0.0776129961013794,
-0.2281993329524994,
-0.0318048894405365,
-0.06819500029087067,
0.11941894143819809,
0.14152806997299194,
-0.2497839778661728,
-0.20338138937950134,
-0.1398550570011139,
-0.042044151574373245,
0.15495140850543976,
-0.01611330918967724,
-0.013432184234261513,
0.33365368843078613,
0.05722813308238983,
-0.043510060757398605,
-0.08217791467905045,
0.19352774322032928,
0.05802733823657036,
-0.016403237357735634,
0.1287286877632141,
0.21573102474212646,
0.05988908186554909,
-0.0652557983994484,
-0.07686217129230499,
-0.05294981226325035,
0.11031839996576309,
-0.02085454948246479,
-0.1718621402978897,
0.08401493728160858,
-0.02283097431063652,
-0.007306758780032396,
-0.2307656854391098,
0.1580110788345337,
-0.04634280130267143,
-0.060512810945510864,
-0.2469002604484558,
-0.06842800974845886,
0.03080766461789608,
0.22945892810821533,
-0.10924452543258667,
0.180153951048851,
0.042992327362298965,
0.2754633128643036,
0.0097954161465168,
0.2198989987373352,
0.051959142088890076,
0.1504867523908615,
-0.16258582472801208,
-0.10890154540538788,
0.21858097612857819,
-0.09916675835847855,
-0.11062178015708923,
0.07935280352830887,
-0.02385171316564083,
-0.24843958020210266,
-0.0736091285943985,
-0.09271686524152756,
0.21958330273628235,
0.03876885771751404,
0.22154662013053894,
-0.12960371375083923,
-0.2779904901981354,
-0.029106495901942253,
-0.12046344578266144,
0.11439034342765808,
-0.08965946733951569,
0.025698253884911537,
0.07069703191518784,
-0.34396910667419434,
0.12684287130832672,
0.058923978358507156,
0.02105446718633175,
0.002670454792678356,
-0.03972528502345085,
-0.09106289595365524,
0.1961161494255066,
0.00819508358836174,
0.12364276498556137,
0.14074383676052094,
-0.12579059600830078,
0.1123904436826706,
0.03950472176074982,
0.07444461435079575,
-0.08191678673028946,
-0.14372135698795319,
-0.13509108126163483,
0.01539035327732563,
-0.06636560708284378,
0.18843847513198853,
-0.07876171916723251,
-0.05652016028761864,
0.05550777539610863,
-0.12300736457109451,
-0.09981778264045715,
-0.27345287799835205,
-0.0033577189315110445,
0.210207998752594,
-0.015126475133001804,
0.0029997951351106167,
0.1179034635424614,
-0.13301678001880646,
-0.08099588006734848,
-0.011524061672389507,
0.34532779455184937,
-0.1704571694135666,
-0.2743678092956543,
-0.037368036806583405,
-0.04234878718852997,
0.12545093894004822,
-0.00698305806145072,
-0.026966102421283722,
0.07246145606040955,
0.14234209060668945,
-0.11875848472118378,
-0.17310075461864471,
-0.19230501353740692,
-0.14777617156505585,
0.10451064258813858,
-0.034957338124513626,
0.11817997694015503,
0.47233232855796814,
0.026927553117275238,
-0.08227703720331192,
-0.059119053184986115,
0.10035138577222824,
-0.03056817688047886,
0.05579087510704994,
0.048490941524505615,
-0.08158814162015915,
-0.22226300835609436,
0.1867658495903015,
-0.18494443595409393,
-0.11719819903373718,
-0.20542897284030914,
-0.14114722609519958,
-0.27370187640190125,
0.1779288500547409,
0.0914473608136177,
-0.165885791182518,
0.0021159511525183916,
-0.2605166435241699,
0.21205244958400726,
-0.05735098198056221,
0.06513356417417526,
-0.07727225124835968,
-0.11473558843135834,
0.08484059572219849,
-0.24337072670459747,
0.14632369577884674,
0.14103275537490845,
-0.0721394345164299,
0.10381903499364853,
0.04741627722978592,
0.062032442539930344,
-0.06643837690353394,
0.001044703647494316,
-0.13689105212688446,
0.12943682074546814,
0.07689827680587769,
0.2272844910621643,
0.1341218501329422,
-0.08047034591436386,
-0.043536435812711716,
-0.31319674849510193,
0.21155567467212677,
0.039781179279088974,
-0.21840178966522217,
-0.12403414398431778,
-0.029820352792739868,
0.04769328609108925,
-0.1149032860994339,
-0.16098299622535706,
-0.1719387322664261,
-0.02670186012983322,
0.2903826832771301,
0.19967436790466309,
-0.03865408897399902,
-0.047648169100284576,
0.03417918458580971,
-0.27107536792755127,
-0.07092487812042236,
0.009271706454455853,
-0.1329619437456131,
0.02952747419476509,
-0.048879001289606094,
0.08395295590162277,
0.05984100326895714,
0.21834421157836914,
-0.24394625425338745,
0.0656600371003151,
-0.0802709311246872,
-0.04455862194299698
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. in this gene.3. Somatic mosaicism for the AKT1 c.49G>A variant is the only pathogenic variant identified to date in individuals with clinically confirmed PS .4. The c.49G>A variant can be detected by sequence analysis of the surrounding region. Sequence analysis detects variants that are benign, likely benign, of uncertain significance, likely pathogenic, or pathogenic. Pathogenic variants may include small intragenic deletions/insertions and missense, nonsense, and splice site variants; typically, exon or whole-gene deletions/duplications are not detected. For issues to consider in interpretation of sequence analysis results, click here.5. Although a single AKT1 variant has been reported, it is possible that other variants in this gene detectable by sequence analysis could be causative of disease.6. Gene-targeted deletion/duplication analysis detects intragenic deletions or duplications. Methods used may include: quantitative PCR, long-range PCR, multiplex ligation-dependent probe amplification ( | [
0.04083259776234627,
-0.048153575509786606,
-0.0744125172495842,
-0.032589592039585114,
0.06591228395700455,
-0.12345369905233383,
0.03166402503848076,
-0.17303591966629028,
-0.08039501309394836,
-0.04992571845650673,
0.20880046486854553,
-0.061653174459934235,
-0.04279247298836708,
0.04544651508331299,
-0.09626749157905579,
0.11916691064834595,
-0.052134472876787186,
0.08000922203063965,
-0.04356583580374718,
0.2597799301147461,
0.12129262089729309,
-0.22743938863277435,
0.11494606733322144,
0.05311169847846031,
0.059365592896938324,
-0.20696614682674408,
0.2788683772087097,
0.07853822410106659,
-0.10727224498987198,
-0.11976007372140884,
0.09501469135284424,
0.08589430898427963,
0.0076768179424107075,
-0.19069242477416992,
-0.04434157907962799,
-0.3525192141532898,
-0.16276642680168152,
0.05445684492588043,
0.11613506078720093,
0.00219385395757854,
0.1813926100730896,
-0.034379106014966965,
0.06973596662282944,
-0.02821340411901474,
0.028191903606057167,
-0.17221730947494507,
0.1423294097185135,
0.03416513279080391,
0.08174412697553635,
0.14997577667236328,
-0.06605193763971329,
0.05212979391217232,
0.1276773363351822,
-0.052283406257629395,
0.09571986645460129,
0.012911234982311726,
0.006385245360434055,
-0.14795254170894623,
-0.24599801003932953,
-0.10964438319206238,
-0.03706466779112816,
0.04054289311170578,
-0.12467982620000839,
-0.2881774306297302,
0.26386627554893494,
-0.13039100170135498,
-0.022227264940738678,
0.050680335611104965,
0.24414674937725067,
-0.03455887362360954,
0.0990501195192337,
-0.1368362009525299,
0.010261000134050846,
-0.0689447820186615,
-0.006094370968639851,
-0.059085551649332047,
0.1939174085855484,
0.042661894112825394,
0.1262189745903015,
-0.2844933271408081,
0.006104361731559038,
-0.2131681740283966,
-0.1708112508058548,
0.1890747994184494,
-0.00501974718645215,
-0.32727763056755066,
-0.06963789463043213,
-0.1679784059524536,
-0.04573101922869682,
0.1126335933804512,
-0.05024613440036774,
0.1417590230703354,
0.22404736280441284,
0.3876514732837677,
0.13591909408569336,
-0.046428609639406204,
-0.06146550923585892,
0.11538165807723999,
-0.0913800522685051,
0.0402313731610775,
-0.022228626534342766,
0.11641921103000641,
-0.3157862424850464,
0.03510467708110809,
0.20059551298618317,
-0.045490775257349014,
0.05703221261501312,
-0.11617974936962128,
-0.009535016492009163,
0.002680371515452862,
-0.1056542843580246,
-0.0967898741364479,
-0.10226523131132126,
-0.07996624708175659,
-0.08308406919240952,
-0.1316487193107605,
-0.01858219876885414,
0.05717022344470024,
-0.1682494580745697,
0.0548672080039978,
0.058813855051994324,
-0.076101154088974,
0.013781880959868431,
0.14498333632946014,
-0.023669838905334473,
-0.06609151512384415,
0.2504091262817383,
-0.1686801314353943,
0.14812281727790833,
-0.027262534946203232,
0.051860690116882324,
0.10854768007993698,
0.03554057329893112,
-0.0023622745648026466,
0.07659871876239777,
-0.18326202034950256,
-0.1386176347732544,
-0.044353120028972626,
0.07950245589017868,
-0.030563566833734512,
0.24413566291332245,
0.1861754208803177,
0.2631155848503113,
0.025934545323252678,
0.059242140501737595,
0.04412544146180153,
0.18386366963386536,
-0.11335429549217224,
-0.06419693678617477,
-0.12301529198884964,
0.06591812521219254,
-0.054029081016778946,
0.3128737211227417,
-0.014238345436751842,
-0.08928995579481125,
-0.06778711825609207,
-0.06346076726913452,
0.11544689536094666,
-0.19161896407604218,
0.03890983387827873,
0.07979807257652283,
-0.043148674070835114,
0.12190251797437668,
-0.1430019587278366,
0.28673890233039856,
0.13065488636493683,
0.0891186073422432,
0.021550610661506653,
0.13015532493591309,
-0.01800108328461647,
-0.0713714137673378,
0.04711749777197838,
-0.024655580520629883,
0.0004337175050750375,
-0.04578127712011337,
0.09773902595043182,
-0.04386063665151596,
-0.04730549082159996,
-0.01178177073597908,
-0.14534103870391846,
0.02940082922577858,
-0.1046648770570755,
-0.03197811171412468,
-0.11173241585493088,
-0.08696319162845612,
-0.13642510771751404,
0.00746501749381423,
0.22265319526195526,
-0.17015066742897034,
0.2648395597934723,
0.14648431539535522,
0.05733548477292061,
-0.1195329874753952,
-0.1677001416683197,
0.013221940025687218,
-0.20805662870407104,
-0.01499302126467228,
0.1422886848449707,
0.07331078499555588,
-0.07849112153053284,
0.026219196617603302,
0.07603462040424347,
-0.2154022604227066,
0.04282812774181366,
0.0031918336171656847,
0.1100364401936531,
0.08886729925870895,
0.08364896476268768,
0.06007162854075432,
0.1541556864976883,
0.10449458658695221,
0.19702468812465668,
-0.07378117740154266,
0.04243903607130051,
0.0903104916214943,
-0.13177256286144257,
0.060756534337997437,
-0.17137673497200012,
-0.020559415221214294,
0.2185932993888855,
-0.03579931706190109,
0.13287940621376038,
-0.08859153836965561,
-0.2454623281955719,
-0.06768669188022614,
0.015863928943872452,
-0.09687336534261703,
-0.0643533319234848,
-0.03215951472520828,
-0.02669401280581951,
0.06257595866918564,
-0.05753399431705475,
-0.046217139810323715,
-0.009111288003623486,
-0.20855920016765594,
0.00669841468334198,
0.11908885836601257,
0.028768496587872505,
-0.006416282616555691,
0.11155436187982559,
-0.10052109509706497,
-0.050842151045799255,
0.03910332918167114,
0.048602666705846786,
-0.030628424137830734,
0.006258868146687746,
0.08012476563453674,
-0.06061345338821411,
-0.28534162044525146,
0.08826326578855515,
-0.11983241140842438,
-0.10795781761407852,
0.11876577883958817,
-0.004350947216153145,
-0.29420384764671326,
-0.07842675596475601,
-0.11593976616859436,
0.08272317796945572,
0.15518224239349365,
0.0023921397514641285,
0.17384196817874908,
0.253508597612381,
0.029042953625321388,
-0.08985864371061325,
-0.2708834409713745,
0.06849785149097443,
-0.11669100821018219,
-0.03759680315852165,
-0.053364161401987076,
-0.09703785181045532,
-0.22455652058124542,
0.1382661610841751,
-0.07487180083990097,
0.061772655695676804,
-0.05458441376686096,
0.09936568886041641,
0.19913478195667267,
-0.01716206967830658,
0.17105691134929657,
0.1031966432929039,
0.001752053271047771,
-0.0076898992992937565,
-0.10670669376850128,
0.1946788728237152,
0.14468693733215332,
0.004633344244211912,
-0.11574920266866684,
0.04869982227683067,
0.10657624155282974,
0.020047137513756752,
-0.051454562693834305,
0.19048422574996948,
0.04313679412007332,
0.008701816201210022,
-0.046418312937021255,
0.06854334473609924,
-0.05137159302830696,
-0.03494105860590935,
0.030878519639372826,
-0.14481358230113983,
0.10843291133642197,
0.06500711292028427,
-0.06299672275781631,
-0.11132414638996124,
0.01497679203748703,
0.11573608219623566,
0.06891090422868729,
0.02674565464258194,
-0.0018873057560995221,
-0.06629643589258194,
-0.2068864405155182,
0.11011464148759842,
-0.17015497386455536,
0.1680358648300171,
-0.08157128840684891,
0.19163715839385986,
0.15786860883235931,
-0.07246185839176178,
0.06449777632951736,
0.19016115367412567,
-0.17846515774726868,
0.10621491074562073,
0.23115989565849304,
0.16267341375350952,
0.05257447063922882,
-0.04926413297653198,
-0.18158994615077972,
0.1350708156824112,
-0.08141037076711655,
0.11170366406440735,
0.04327290505170822,
0.018321426585316658,
-0.12993745505809784,
0.0318446084856987,
-0.08139432966709137,
0.1163581907749176,
0.06361199170351028,
-0.03609854727983475,
-0.16795989871025085,
-0.1335505098104477,
0.12335442751646042,
-0.1422615945339203,
-0.07048166543245316,
0.34178611636161804,
0.11863067746162415,
0.10605283826589584,
-0.12303828448057175,
-0.01982080563902855,
-0.05136197432875633,
-0.05502163991332054,
-0.10624101758003235,
-0.17935162782669067,
0.0079043535515666,
-0.08078143000602722,
0.22690396010875702,
0.0701962485909462,
0.2921740412712097,
0.024807211011648178,
-0.14691759645938873,
0.03212825581431389,
0.06046414002776146,
-0.04644519463181496,
-0.17454221844673157,
-0.025700200349092484,
-0.1488451361656189,
-0.0780324637889862,
-0.034565843641757965,
0.13305193185806274,
0.009010745212435722,
0.17160528898239136,
0.2446536421775818,
0.22635197639465332,
0.07391370087862015,
-0.16268965601921082,
-0.06764499843120575,
0.07919400930404663,
-0.18034705519676208,
0.09103265404701233,
0.026117097586393356,
-0.0931529775261879,
0.16940109431743622,
0.19217240810394287,
0.12269110232591629,
-0.15631558001041412,
0.03738677501678467,
0.1257963478565216,
-0.2518732249736786,
-0.006420429330319166,
0.09396886825561523,
-0.04551513493061066,
0.09017735719680786,
0.11268069595098495,
0.1296144425868988,
0.007211335934698582,
0.02559228055179119,
0.05703900009393692,
-0.07856418192386627,
-0.14883556962013245,
-0.12511207163333893,
-0.164437398314476,
-0.21831512451171875,
-0.23554976284503937,
-0.002520481124520302,
0.15589027106761932,
-0.04054522514343262,
0.005681084003299475,
-0.03691819682717323,
-0.03085891157388687,
0.0450744591653347,
0.3242742121219635,
-0.14108367264270782,
0.07422709465026855,
-0.1284172534942627,
-0.08637407422065735,
-0.17739634215831757,
0.006359155755490065,
0.038464177399873734,
0.028298428282141685,
-0.06873361766338348,
-0.0008603341993875802,
0.08522550761699677,
0.30161675810813904,
0.03771137818694115,
-0.06159822642803192,
0.03389129415154457,
-0.0669107660651207,
-0.10163786262273788,
0.25402212142944336,
0.08694197982549667,
0.1659921556711197,
0.2290947437286377,
0.1219198927283287,
-0.16864480078220367,
-0.04269139841198921,
-0.09633611142635345,
-0.013634633272886276,
0.2663894593715668,
-0.08229179680347443,
0.2774161100387573,
-0.1407097578048706,
0.14585129916667938,
0.17191170156002045,
-0.028468463569879532,
0.16817669570446014,
0.047687556594610214,
-0.023916056379675865,
0.013237440027296543,
0.06328295171260834,
-0.04293380305171013,
0.019217289984226227,
-0.08111890405416489,
-0.0070882453583180904,
0.046661850064992905,
-0.17851346731185913,
0.1558089405298233,
0.10874854028224945,
-0.026490284129977226,
-0.009125016629695892,
-0.13955320417881012,
0.01402820460498333,
-0.17243213951587677,
-0.012244676239788532,
0.2698586881160736,
0.037443939596414566,
0.026037391275167465,
-0.06698670983314514,
0.052562978118658066,
0.020272711291909218,
0.16026636958122253,
0.054718922823667526,
0.06230079382658005,
-0.16317644715309143,
0.09787684679031372,
-0.10906726121902466,
-0.005596568807959557,
-0.03902031481266022,
-0.037457723170518875,
0.009757958352565765,
-0.08746612817049026,
-0.00949897337704897,
0.143135666847229,
0.15821178257465363,
0.022163014858961105,
-0.17407283186912537,
0.05170895904302597,
0.21503987908363342,
0.007367484271526337,
-0.09910779446363449,
0.036422766745090485,
-0.10907506197690964,
-0.022830918431282043,
0.03223118185997009,
0.2179315984249115,
0.08723723888397217,
-0.12597350776195526,
-0.1690068244934082,
-0.002729445695877075,
-0.05457335337996483,
-0.1129915714263916,
-0.11703164130449295,
0.030468907207250595,
0.2312351018190384,
0.0944838672876358,
-0.003554902970790863,
-0.07629131525754929,
-0.078578881919384,
0.017785659059882164,
-0.3280109763145447,
-0.03382248058915138,
0.04755068197846413,
-0.2183631956577301,
-0.0033981360029429197,
0.06250833719968796,
-0.17641329765319824,
0.1520056426525116,
-0.2001378834247589,
-0.03034188225865364,
-0.09526479989290237,
0.027625804767012596,
-0.028222888708114624,
0.007603466510772705,
-0.207692950963974,
0.054515495896339417,
0.06071905046701431,
-0.1041186973452568,
-0.3241477608680725,
-0.08224142342805862,
0.21511127054691315,
-0.1664867103099823,
0.076102115213871,
-0.1540982872247696,
-0.04119382053613663,
-0.20027446746826172,
0.13017186522483826,
-0.022283749654889107,
0.1624143421649933,
0.1742745041847229,
0.045253656804561615,
-0.26497170329093933,
-0.01754203625023365,
-0.08961806446313858,
0.02352249249815941,
0.10768197476863861,
0.10362991690635681,
0.014552428387105465,
-0.0836213007569313,
0.15111690759658813,
-0.004184954334050417,
0.43351149559020996,
0.14145419001579285,
0.08493544906377792,
-0.13166415691375732,
-0.018241386860609055,
-0.08308825641870499,
-0.33569830656051636,
0.17321842908859253,
0.16122964024543762,
-0.010948868468403816,
0.10819640755653381,
0.24285006523132324,
-0.0033582996111363173,
0.0072222063317894936,
0.025680383667349815,
-0.0148019352927804,
0.19954897463321686,
0.3059728145599365,
0.07773458957672119,
-0.032107554376125336,
0.08793526887893677,
0.025084180757403374,
-0.26089534163475037,
-0.13612209260463715,
0.2408427596092224,
0.22409123182296753,
-0.07654426246881485,
-0.009360674768686295,
-0.2777644991874695,
-0.08587198704481125,
-0.17390279471874237,
-0.036558497697114944,
0.07355867326259613,
-0.2886433005332947,
-0.0961284264922142,
-0.2235066443681717,
0.13781610131263733,
0.11516920477151871,
-0.06304386258125305,
0.07952206581830978,
0.220147043466568,
0.05878470838069916,
-0.014067290350794792,
-0.10308535397052765,
0.10659929364919662,
0.052709538489580154,
-0.1878937929868698,
0.13712529838085175,
0.20106801390647888,
0.08479756116867065,
0.0032166987657546997,
-0.0668182522058487,
-0.06971806287765503,
0.17175571620464325,
0.021151771768927574,
-0.08715235441923141,
0.062321145087480545,
0.007301562465727329,
0.02216724120080471,
-0.25131383538246155,
0.21943649649620056,
-0.0853436291217804,
-0.13843519985675812,
-0.1403629183769226,
-0.08746843039989471,
-0.0552104189991951,
0.33246734738349915,
-0.21926435828208923,
0.2089982032775879,
0.025999605655670166,
0.3337777256965637,
-0.04016173630952835,
0.29662176966667175,
0.04301552101969719,
0.19122590124607086,
-0.23952201008796692,
-0.16004356741905212,
0.289046049118042,
-0.12683016061782837,
-0.07673739641904831,
-0.0014781856443732977,
-0.05507514253258705,
-0.05788097903132439,
-0.10766160488128662,
-0.14338932931423187,
0.14926867187023163,
0.05848522484302521,
0.06838595867156982,
-0.08027542382478714,
-0.2316875010728836,
-0.0386526845395565,
-0.10841265320777893,
0.02185077965259552,
-0.08864304423332214,
0.07508658617734909,
0.06435146927833557,
-0.23507167398929596,
0.08714129030704498,
-0.06950199604034424,
-0.09438778460025787,
0.0012997358571738005,
-0.02896765060722828,
-0.06404148042201996,
0.20981237292289734,
-0.17838189005851746,
0.058050669729709625,
0.11912757158279419,
-0.20932719111442566,
0.021676303818821907,
0.06717294454574585,
0.10555297136306763,
-0.1065809577703476,
-0.1064845621585846,
-0.10813667625188828,
-0.1459842473268509,
-0.09318789094686508,
0.1998974233865738,
0.04729084298014641,
-0.027167895808815956,
-0.053486887365579605,
-0.018402928486466408,
-0.14710909128189087,
-0.2298373430967331,
-0.021154040470719337,
0.14904700219631195,
0.018090205267071724,
0.06959284096956253,
0.09770400822162628,
0.007964086718857288,
-0.052241358906030655,
0.01976805180311203,
0.2987799644470215,
-0.16609452664852142,
-0.28716519474983215,
-0.08101619780063629,
-0.10342666506767273,
0.03749026358127594,
0.03170835226774216,
0.03921367600560188,
0.1620793342590332,
0.041953980922698975,
-0.15216758847236633,
-0.15100833773612976,
-0.03856769576668739,
-0.10406817495822906,
0.04174716770648956,
-0.07955167442560196,
0.010865586809813976,
0.6158829927444458,
0.04280843585729599,
-0.0687038004398346,
-0.0681292936205864,
0.09614690393209457,
-0.016251176595687866,
0.0996585339307785,
0.04339536651968956,
-0.009389666840434074,
-0.19976989924907684,
0.21119455993175507,
-0.20423802733421326,
-0.020264487713575363,
-0.2972160577774048,
-0.07270987331867218,
-0.22941036522388458,
0.24107691645622253,
0.15937252342700958,
-0.12040822952985764,
0.10455232113599777,
-0.07101910561323166,
0.17217819392681122,
0.03495952859520912,
-0.004160101991146803,
-0.10149604082107544,
-0.12049903720617294,
0.010526366531848907,
-0.23699358105659485,
0.18441730737686157,
0.07953079044818878,
-0.1980382800102234,
0.39299002289772034,
0.047310445457696915,
-0.00675681047141552,
-0.07980523258447647,
0.05430951341986656,
-0.09217601269483566,
0.1819416582584381,
0.15234409272670746,
0.08510956168174744,
0.061046283692121506,
-0.1039462685585022,
-0.017887841910123825,
-0.17482228577136993,
0.1509028971195221,
-0.10021255165338516,
-0.16142790019512177,
-0.08476291596889496,
-0.025295406579971313,
0.05454622581601143,
0.0069777509197592735,
-0.20534469187259674,
-0.10766907036304474,
-0.0834522694349289,
0.2334650754928589,
0.23916175961494446,
0.06357475370168686,
-0.04887440428137779,
0.0043367124162614346,
-0.16112877428531647,
-0.08119428157806396,
0.039259009063243866,
-0.1110139936208725,
-0.021266788244247437,
0.0008153329254128039,
-0.11711769551038742,
-0.04079458490014076,
0.20182745158672333,
-0.0047807819209992886,
0.06190604716539383,
-0.08980884402990341,
0.009986814111471176
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. and splice site variants; typically, exon or whole-gene deletions/duplications are not detected. For issues to consider in interpretation of sequence analysis results, click here.5. Although a single AKT1 variant has been reported, it is possible that other variants in this gene detectable by sequence analysis could be causative of disease.6. Gene-targeted deletion/duplication analysis detects intragenic deletions or duplications. Methods used may include: quantitative PCR, long-range PCR, multiplex ligation-dependent probe amplification (MLPA), and a gene-targeted microarray designed to detect single-exon deletions or duplications.6. No data on detection rate of gene-targeted deletion/duplication analysis are available.Clinical CharacteristicsClinical DescriptionProteus syndrome (PS) displays a wide range of severity. Some individuals are minimally affected, but others are quite severely affected. Among the individuals in the NIH PS cohort, there was a projected 25% mortality before the age of 20 years .Most affected | [
0.005320061929523945,
0.08368752896785736,
-0.01490770187228918,
-0.18681538105010986,
0.11814724653959274,
-0.11614517867565155,
0.04100937023758888,
-0.09215271472930908,
-0.016321640461683273,
0.02919083833694458,
0.1457432359457016,
-0.009896925650537014,
0.06264275312423706,
-0.03702779486775398,
-0.16083763539791107,
0.1851864755153656,
0.05709901452064514,
-0.05816621705889702,
-0.06226619705557823,
0.14071837067604065,
0.01893354393541813,
-0.04310014843940735,
-0.035032372921705246,
0.01782999187707901,
0.15144556760787964,
-0.25913187861442566,
0.2103516012430191,
0.13432253897190094,
-0.12879881262779236,
0.04519180953502655,
-0.0029600176494568586,
0.03433572128415108,
-0.06977012753486633,
-0.2507546842098236,
-0.052843719720840454,
-0.30205193161964417,
-0.1421496421098709,
0.11462675034999847,
0.13989610970020294,
-0.0845787525177002,
0.042127061635255814,
-0.010160664096474648,
0.1078450158238411,
-0.05861474201083183,
0.17708492279052734,
0.03702316805720329,
0.08296319842338562,
0.08413856476545334,
0.09487134218215942,
0.11190936714410782,
0.1374785453081131,
0.032360948622226715,
0.018713857978582382,
0.022246722131967545,
0.11101392656564713,
-0.033721424639225006,
0.02106039598584175,
-0.21908502280712128,
-0.36763855814933777,
-0.12342323362827301,
-0.0013803750043734908,
0.02484109066426754,
-0.05025611072778702,
-0.2929080128669739,
0.14957250654697418,
-0.2665087580680847,
0.05848749727010727,
0.16366635262966156,
0.12727615237236023,
-0.054742272943258286,
0.20013587176799774,
-0.15079587697982788,
0.05395445600152016,
-0.12229592353105545,
-0.031055578961968422,
-0.025598006322979927,
0.04269303381443024,
-0.07078470289707184,
-0.010600883513689041,
-0.3027695417404175,
-0.02875891514122486,
-0.21492284536361694,
-0.01210574246942997,
0.15408852696418762,
-0.052378155291080475,
-0.2078951746225357,
0.04111875966191292,
-0.05267845466732979,
-0.025459451600909233,
0.09970638155937195,
-0.011574387550354004,
-0.09755217283964157,
0.10244527459144592,
0.15924373269081116,
0.1318766474723816,
-0.09045348316431046,
0.07911252230405807,
0.00676346942782402,
-0.1491468846797943,
0.061348941177129745,
0.06264173239469528,
0.08951515704393387,
-0.1696913242340088,
-0.022008487954735756,
0.1736009567975998,
-0.025210600346326828,
-0.03251105919480324,
-0.07698416709899902,
0.05720936879515648,
-0.04782061651349068,
-0.08553290367126465,
-0.02287243865430355,
0.003293478861451149,
-0.0934210792183876,
-0.2846873998641968,
-0.06632134318351746,
0.14171572029590607,
-0.05206703022122383,
-0.17641186714172363,
-0.008139555342495441,
-0.04267245531082153,
-0.09999437630176544,
0.02667943201959133,
-0.0025895689614117146,
0.07651636004447937,
-0.006825584452599287,
0.24121657013893127,
-0.21154730021953583,
0.003319266252219677,
-0.10204960405826569,
0.0853593721985817,
0.08687634766101837,
0.007981535978615284,
-0.20483486354351044,
0.1089528501033783,
-0.014332537539303303,
-0.18915101885795593,
-0.06115187332034111,
0.22037336230278015,
-0.07061267644166946,
0.21707861125469208,
0.22373338043689728,
0.23344503343105316,
-0.01487982552498579,
0.03153231367468834,
0.08324239403009415,
0.21015480160713196,
-0.1353033035993576,
0.06078333035111427,
-0.018178418278694153,
0.11561109125614166,
-0.16444677114486694,
0.2434144914150238,
0.13875821232795715,
-0.06407351791858673,
-0.1679052859544754,
0.01935633085668087,
0.006892884150147438,
-0.2098691463470459,
0.017641209065914154,
0.18225179612636566,
-0.07488734275102615,
-0.030048904940485954,
-0.04952733963727951,
0.2081597000360489,
0.09905478358268738,
0.22937726974487305,
-0.04086033254861832,
0.047104451805353165,
-0.027507860213518143,
-0.12767961621284485,
0.10462062805891037,
0.08277808129787445,
0.18443891406059265,
-0.08506746590137482,
0.01896020956337452,
0.04069508984684944,
0.17466695606708527,
-0.019836559891700745,
0.06834916025400162,
0.14046695828437805,
-0.045736636966466904,
-0.05981184542179108,
-0.23344847559928894,
-0.10845105350017548,
-0.1328819990158081,
0.028171481564641,
0.11303478479385376,
-0.28514647483825684,
0.1613088697195053,
0.16997912526130676,
-0.08102802187204361,
-0.19214779138565063,
-0.09885900467634201,
-0.00045998237328603864,
-0.25524643063545227,
-0.07851812988519669,
0.07210032641887665,
-0.0352371446788311,
-0.04508074373006821,
-0.02027318999171257,
0.08652172237634659,
-0.09797225892543793,
0.06341172009706497,
0.15722322463989258,
0.16666284203529358,
-0.008464226499199867,
-0.042172759771347046,
-0.04376602917909622,
0.027009792625904083,
0.09655702114105225,
0.21920980513095856,
-0.17672564089298248,
0.15343783795833588,
-0.08873751014471054,
-0.0893574133515358,
0.053355734795331955,
-0.1784038543701172,
0.006542841903865337,
0.3330402374267578,
-0.1401287168264389,
0.15721605718135834,
-0.0625038594007492,
-0.1708662062883377,
-0.058720964938402176,
0.1308722198009491,
-0.0524502731859684,
0.037952762097120285,
0.06375173479318619,
-0.056081488728523254,
0.05139355733990669,
-0.00200686720199883,
-0.1427769660949707,
0.10625996440649033,
-0.18541282415390015,
-0.11700368672609329,
0.016312748193740845,
0.09816156327724457,
0.09369736909866333,
0.19667568802833557,
-0.012654686346650124,
-0.028633590787649155,
0.05609199404716492,
0.09078925848007202,
0.09347137063741684,
0.11140424758195877,
-0.04339786246418953,
0.0013139571528881788,
-0.18092501163482666,
0.0917971059679985,
-0.09519731253385544,
-0.15367363393306732,
0.06896801292896271,
-0.014762050472199917,
-0.24092859029769897,
-0.1302335262298584,
-0.019700272008776665,
0.01638832315802574,
0.10846768319606781,
0.06581711024045944,
0.09260230511426926,
0.21146877110004425,
0.1339247226715088,
0.07207880914211273,
-0.3714540898799896,
0.07216493040323257,
-0.10633376240730286,
0.040771931409835815,
-0.11986812204122543,
-0.180526465177536,
-0.1509193778038025,
0.08253618329763412,
0.01783258467912674,
0.07856656610965729,
0.0020770069677382708,
0.12604694068431854,
0.07679136842489243,
0.02802107110619545,
0.24242143332958221,
0.037548575550317764,
0.10464829951524734,
0.008369927294552326,
-0.041879117488861084,
0.10854639858007431,
0.18039244413375854,
0.005480507388710976,
-0.2231215089559555,
0.18174509704113007,
0.02887607552111149,
0.019373849034309387,
0.00747100543230772,
0.31342899799346924,
0.04552977904677391,
-0.080503910779953,
0.018598269671201706,
0.10945475846529007,
0.03637169674038887,
-0.05371202155947685,
0.06583155691623688,
-0.18876269459724426,
0.17658105492591858,
0.04414850473403931,
-0.17569315433502197,
-0.045166078954935074,
-0.07663589715957642,
0.07466655969619751,
0.06531766802072525,
-0.019425584003329277,
-0.006102680694311857,
0.010071937926113605,
-0.13164234161376953,
0.045424651354551315,
-0.09013473987579346,
0.049704935401678085,
-0.010338529013097286,
0.09881950914859772,
-0.0022769602946937084,
0.010683711618185043,
0.15552040934562683,
0.049699075520038605,
-0.06342028826475143,
0.003628938226029277,
0.18354979157447815,
0.006642818916589022,
0.024435654282569885,
0.03040238842368126,
-0.11361164599657059,
0.09550441056489944,
-0.03146129474043846,
0.10620716214179993,
-0.045331474393606186,
0.03284573554992676,
-0.1479843556880951,
-0.12022331357002258,
0.0543220154941082,
0.16427826881408691,
0.06469299644231796,
-0.13811856508255005,
-0.04720853269100189,
0.013998949900269508,
0.008157266303896904,
-0.2381463646888733,
-0.1732282042503357,
0.11736800521612167,
0.10892815887928009,
0.10978973656892776,
-0.062370553612709045,
0.009725590236485004,
-0.045187342911958694,
-0.12527665495872498,
-0.023981411010026932,
-0.21844333410263062,
0.02460094355046749,
-0.23606830835342407,
0.3900395333766937,
0.10651179403066635,
0.22697260975837708,
0.05238981544971466,
-0.054487258195877075,
0.06891831755638123,
0.02816501259803772,
0.05392129719257355,
-0.043084561824798584,
0.06338880956172943,
-0.05086076259613037,
-0.09627483040094376,
-0.009605036117136478,
0.07123935222625732,
0.09102696180343628,
0.12377960234880447,
0.10843823105096817,
0.09327846020460129,
-0.001270590117201209,
-0.04080105572938919,
0.048857029527425766,
0.09149903059005737,
-0.22296258807182312,
0.09764396399259567,
-0.13365140557289124,
-0.05420801416039467,
-0.021891091018915176,
0.014519024640321732,
0.1494143307209015,
-0.2075694352388382,
-0.03384803608059883,
0.210968017578125,
-0.2445487678050995,
0.10086626559495926,
0.08880969136953354,
-0.14808249473571777,
0.147005096077919,
0.05333734676241875,
0.036729730665683746,
0.11307702958583832,
-0.003254220588132739,
0.20258383452892303,
-0.012982138432562351,
-0.14897237718105316,
-0.16231991350650787,
-0.06518738716840744,
-0.12536901235580444,
-0.08288721740245819,
-0.0026659173890948296,
0.23321367800235748,
0.06185102090239525,
0.03357647359371185,
-0.05267628654837608,
0.010684355162084103,
-0.036422789096832275,
0.2699210047721863,
-0.10590845346450806,
0.007917885668575764,
-0.050925228744745255,
-0.06461023539304733,
-0.07843142747879028,
-0.108098104596138,
-0.055430818349123,
0.06661563366651535,
-0.132497176527977,
-0.08950161933898926,
0.04208022356033325,
0.0773727297782898,
0.08873159438371658,
-0.1364675611257553,
-0.1088092252612114,
0.03850437328219414,
-0.20662640035152435,
0.14149779081344604,
-0.03147019445896149,
0.1419087052345276,
0.21677666902542114,
-0.03777196630835533,
-0.24578692018985748,
0.045545805245637894,
-0.03562946617603302,
0.10639121383428574,
0.09312405437231064,
-0.11131331324577332,
0.3225081264972687,
-0.07211486250162125,
0.29380127787590027,
0.048813339322805405,
-0.036462411284446716,
0.02750731073319912,
0.04768775776028633,
0.06374885141849518,
0.01800820790231228,
0.09330200403928757,
0.08249489963054657,
0.08017177879810333,
-0.1069236472249031,
0.06216893345117569,
0.029926732182502747,
-0.05403783544898033,
0.07675255089998245,
0.09707832336425781,
-0.03569209575653076,
-0.0807315930724144,
-0.08339815586805344,
0.10161477327346802,
-0.11546224355697632,
0.05711129307746887,
0.20672041177749634,
-0.0706976130604744,
-0.12199665606021881,
0.035794150084257126,
-0.06880690902471542,
0.033008649945259094,
0.22939074039459229,
0.03964442387223244,
0.03252754732966423,
-0.06824192404747009,
0.018217366188764572,
-0.08489325642585754,
0.0578259713947773,
-0.03713814541697502,
-0.049494095146656036,
0.050614241510629654,
-0.11044318974018097,
-0.03133666142821312,
0.0441536083817482,
0.1287764459848404,
-0.041505228728055954,
-0.14696413278579712,
0.006062292493879795,
0.23470400273799896,
-0.018808072432875633,
-0.10424885153770447,
0.07147425413131714,
-0.18062666058540344,
-0.0330096110701561,
0.08703918755054474,
0.06747715175151825,
0.2302941381931305,
0.05414151772856712,
-0.13762319087982178,
0.06736532598733902,
-0.04269745200872421,
-0.0830269604921341,
-0.16751407086849213,
-0.02109653130173683,
0.190731018781662,
0.04729296639561653,
0.025038087740540504,
-0.036297477781772614,
-0.16176773607730865,
-0.014071192592382431,
-0.29997551441192627,
-0.07035611569881439,
0.12231019139289856,
-0.13436831533908844,
-0.1039465144276619,
0.035370081663131714,
-0.17992839217185974,
-0.07574691623449326,
-0.035999998450279236,
-0.026995470747351646,
-0.1086796447634697,
0.09509110450744629,
-0.01814930886030197,
-0.051511287689208984,
-0.05513754487037659,
0.06131632626056671,
0.031181128695607185,
-0.08991055190563202,
-0.2527017295360565,
-0.08674773573875427,
0.15079884231090546,
-0.0652957558631897,
-0.061079464852809906,
-0.07582030445337296,
0.003162829205393791,
-0.00867138896137476,
-0.020620102062821388,
0.07090847939252853,
0.05831051990389824,
0.12212030589580536,
-0.0720386877655983,
-0.23721522092819214,
0.09752429276704788,
-0.1795492172241211,
0.08462730795145035,
0.19037844240665436,
-0.04000763222575188,
0.050033628940582275,
-0.0706389918923378,
0.12115101516246796,
0.07668855786323547,
0.2030109316110611,
0.2440129518508911,
-0.054969970136880875,
0.04695942625403404,
0.018756499513983727,
-0.0201864056289196,
-0.14766648411750793,
-0.006896712351590395,
0.10883527994155884,
0.018854405730962753,
0.03813338652253151,
0.10564970225095749,
-0.10749523341655731,
0.16057440638542175,
0.05667416751384735,
0.008223019540309906,
0.14329710602760315,
0.2888844311237335,
0.08533619344234467,
0.019978640601038933,
0.06311971694231033,
0.11112985014915466,
-0.17152315378189087,
-0.07796797901391983,
0.22263750433921814,
0.09223630279302597,
0.014339053072035313,
0.04639827460050583,
-0.22894060611724854,
-0.0907699316740036,
-0.22846294939517975,
0.06821013987064362,
0.11452063918113708,
-0.23194672167301178,
0.034170735627412796,
-0.1873600035905838,
0.049993645399808884,
0.04607516899704933,
-0.09652881324291229,
0.08792043477296829,
0.2600404918193817,
0.031184107065200806,
-0.1432236135005951,
-0.10504625737667084,
0.09303049743175507,
0.03885627165436745,
-0.16050219535827637,
0.028617002069950104,
0.25495201349258423,
-0.03842320293188095,
0.025594761595129967,
-0.09452728182077408,
0.003696070984005928,
0.14070363342761993,
-0.1551453173160553,
-0.19003063440322876,
0.09789355099201202,
-0.014187188819050789,
-0.06387583166360855,
-0.24586942791938782,
0.17187227308750153,
0.02594662271440029,
-0.19334056973457336,
-0.07685595750808716,
0.0004712937807198614,
-0.06990504264831543,
0.33236801624298096,
-0.06888244301080704,
0.2006116807460785,
-0.019863782450556755,
0.24005009233951569,
-0.03483358770608902,
0.30494424700737,
-0.07017429172992706,
0.13107356429100037,
-0.32220032811164856,
-0.09624386578798294,
0.24407155811786652,
-0.016762705519795418,
-0.03946215659379959,
0.13396289944648743,
0.008954515680670738,
0.1278303563594818,
0.021446364000439644,
-0.04425797611474991,
0.07159744948148727,
0.0914185419678688,
0.10425443947315216,
0.01560046337544918,
-0.16452017426490784,
-0.14819541573524475,
-0.006310845725238323,
0.04706532880663872,
-0.03924925625324249,
-0.06665793806314468,
0.04320068284869194,
-0.1483856737613678,
0.042204663157463074,
-0.07275596261024475,
-0.07171260565519333,
-0.15984255075454712,
-0.03825727477669716,
-0.018527360633015633,
0.19046781957149506,
-0.07250936329364777,
0.026426061987876892,
0.09900733828544617,
-0.08995531499385834,
0.1861957460641861,
0.07971041649580002,
-0.026877835392951965,
-0.008452188223600388,
-0.14518994092941284,
0.004448221530765295,
-0.1444440484046936,
0.09603916853666306,
0.16313116252422333,
0.09232039749622345,
-0.003260255791246891,
0.04202984645962715,
-0.13978427648544312,
-0.11739012598991394,
-0.18502669036388397,
0.030181946232914925,
0.08465757966041565,
0.05106005072593689,
-0.025141192600131035,
-0.006290481425821781,
0.13842928409576416,
-0.11703412979841232,
0.09214841574430466,
0.28467851877212524,
-0.048352159559726715,
-0.2548843026161194,
-0.02701060101389885,
-0.1631685495376587,
-0.15834689140319824,
-0.02079758606851101,
-0.1601206660270691,
0.0168656874448061,
0.11454561352729797,
-0.004751475062221289,
-0.12002135813236237,
-0.04156103357672691,
0.033427655696868896,
-0.004866151139140129,
-0.11405239999294281,
-0.11884773522615433,
0.5169810652732849,
0.0916944146156311,
0.00001867888931883499,
-0.0784514844417572,
-0.06949443370103836,
-0.0372481644153595,
-0.02393510192632675,
0.08118968456983566,
0.03318922221660614,
-0.12657180428504944,
0.13661734759807587,
-0.27826693654060364,
0.004475272260606289,
-0.19422118365764618,
-0.02041999250650406,
-0.18761584162712097,
0.22457654774188995,
0.06360190361738205,
-0.0628792941570282,
0.17944715917110443,
-0.07840375602245331,
0.07316455990076065,
-0.04689658433198929,
-0.03951346129179001,
-0.05227440595626831,
0.016921749338507652,
0.1251298040151596,
-0.08210914582014084,
0.07028104364871979,
-0.025363681837916374,
-0.20107413828372955,
0.1980539709329605,
0.25364482402801514,
0.034113842993974686,
-0.08778419345617294,
-0.09025950729846954,
-0.11070720851421356,
0.05790248513221741,
0.03719848766922951,
0.025571243837475777,
0.1301383227109909,
0.0387418195605278,
-0.025598229840397835,
-0.216676726937294,
0.0582607202231884,
0.008060730993747711,
-0.13407786190509796,
-0.04283593222498894,
0.1365169882774353,
-0.05614793673157692,
-0.022217679768800735,
-0.2707550823688507,
-0.06614368408918381,
0.017964648082852364,
0.17140987515449524,
0.20057319104671478,
0.08683580905199051,
-0.004310860764235258,
-0.11918100714683533,
-0.20650213956832886,
-0.09455867856740952,
-0.10730680078268051,
0.10293406248092651,
-0.05528596043586731,
-0.014853852801024914,
-0.13428142666816711,
-0.022686844691634178,
0.034653548151254654,
-0.09813426434993744,
0.0955304428935051,
-0.08020707219839096,
-0.09916271269321442
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. -dependent probe amplification (MLPA), and a gene-targeted microarray designed to detect single-exon deletions or duplications.6. No data on detection rate of gene-targeted deletion/duplication analysis are available.Clinical CharacteristicsClinical DescriptionProteus syndrome (PS) displays a wide range of severity. Some individuals are minimally affected, but others are quite severely affected. Among the individuals in the NIH PS cohort, there was a projected 25% mortality before the age of 20 years .Most affected individuals have little or no manifestations at birth. Most typically, the first manifestations of the disorder occur between age six and 18 months with the onset of asymmetric overgrowth; it is most commonly of the feet or hands but may occur anywhere. An exception is that a few (probably <5%) first manifest PS with hemimegencephaly, often associated with CNS migration defects and later intellectual disability. This manifestation is prenatal. In most other affected individuals, the congenital | [
-0.05568387359380722,
-0.1259860247373581,
0.06827894598245621,
-0.34184232354164124,
0.16233709454536438,
-0.03682279586791992,
-0.06349482387304306,
-0.08720190078020096,
-0.12210100889205933,
0.07597542554140091,
0.0027387014124542475,
0.17753538489341736,
0.13332997262477875,
0.021790243685245514,
-0.14637307822704315,
0.025478044524788857,
0.06235721334815025,
0.009255231358110905,
-0.0715080201625824,
0.008112666197121143,
-0.15072110295295715,
-0.13120681047439575,
-0.061783816665410995,
-0.027149327099323273,
0.12379373610019684,
-0.2037046104669571,
0.2356516718864441,
0.05328397825360298,
-0.04706643149256706,
-0.04454803466796875,
-0.000565247843042016,
-0.029479267075657845,
-0.08888557553291321,
-0.1377941220998764,
0.12433399260044098,
-0.11112798750400543,
-0.0884256511926651,
-0.000896377838216722,
0.1808902472257614,
-0.0978301614522934,
-0.06199938803911209,
0.13075269758701324,
-0.12114851176738739,
-0.10867951810359955,
0.36928418278694153,
0.04559515416622162,
-0.15871919691562653,
0.290871798992157,
0.025309240445494652,
0.05422636494040489,
0.21323731541633606,
0.044875528663396835,
0.09905562549829483,
-0.050709616392850876,
0.18068073689937592,
-0.12030517309904099,
0.03979041427373886,
-0.0009483612375333905,
-0.3347003161907196,
-0.010624443180859089,
0.21104227006435394,
-0.1522790640592575,
0.11983640491962433,
-0.40593475103378296,
0.09316658228635788,
-0.2799118459224701,
-0.035960108041763306,
0.15853041410446167,
-0.04637124761939049,
0.05692954361438751,
0.22215574979782104,
-0.35454925894737244,
-0.32337045669555664,
-0.14341236650943756,
-0.18092867732048035,
-0.19723692536354065,
0.040292225778102875,
-0.07771605253219604,
-0.06041228398680687,
-0.08505977690219879,
0.08365810662508011,
-0.017655566334724426,
-0.06928662210702896,
0.1647537499666214,
-0.0978061705827713,
-0.12409269064664841,
0.1390378326177597,
0.13383938372135162,
-0.008627818897366524,
0.11101886630058289,
0.015998294577002525,
-0.18020686507225037,
0.008470394648611546,
-0.0070421709679067135,
0.33290037512779236,
-0.04611241817474365,
0.05418812856078148,
-0.12793849408626556,
-0.19025078415870667,
-0.03969665989279747,
0.0917113646864891,
0.24956268072128296,
-0.029513567686080933,
0.09520211070775986,
0.1015181913971901,
-0.05181531608104706,
0.016398105770349503,
0.16047240793704987,
0.07310708612203598,
0.10267799347639084,
-0.05849377438426018,
-0.19661161303520203,
0.02344861626625061,
-0.16285747289657593,
-0.3917572498321533,
-0.1639346480369568,
0.10145360231399536,
-0.05077747628092766,
-0.2927224040031433,
-0.2504553198814392,
0.0365794375538826,
-0.1213013082742691,
0.09163181483745575,
-0.0008726101368665695,
0.12161414325237274,
0.0962425172328949,
0.17108552157878876,
-0.006085575092583895,
0.1178436428308487,
-0.1273389756679535,
0.0937047153711319,
-0.21834835410118103,
-0.2399536818265915,
-0.3541499674320221,
0.14048141241073608,
0.1188727468252182,
-0.15291424095630646,
-0.14984950423240662,
0.03002297505736351,
0.11875354498624802,
0.2366698831319809,
0.14646907150745392,
0.2686046063899994,
0.08613746613264084,
0.24535898864269257,
0.14949682354927063,
0.1885441094636917,
0.14118854701519012,
0.11468770354986191,
-0.028854647651314735,
0.2363896518945694,
-0.06899905204772949,
0.07881426811218262,
-0.002748270984739065,
0.003614740911871195,
-0.032997988164424896,
0.01335819810628891,
-0.1570972502231598,
-0.18761250376701355,
-0.05625593289732933,
-0.08970555663108826,
-0.07543619722127914,
-0.0734589472413063,
-0.1404925286769867,
-0.20486533641815186,
-0.07346900552511215,
0.018977191299200058,
-0.3110751509666443,
-0.02916540391743183,
-0.06042812019586563,
-0.13436278700828552,
0.02354685217142105,
-0.05869578942656517,
0.21967707574367523,
-0.0207867119461298,
0.03328445926308632,
-0.0005553932278417051,
0.13041521608829498,
-0.050567563623189926,
0.18746288120746613,
0.06619159132242203,
-0.04314052686095238,
0.05586784705519676,
-0.33136796951293945,
-0.0778210461139679,
-0.08796452730894089,
0.034815143793821335,
0.18194623291492462,
-0.3120373487472534,
0.07149489223957062,
0.13868188858032227,
0.05050548166036606,
-0.14867639541625977,
0.026670332998037338,
-0.17941296100616455,
-0.28509223461151123,
0.05246693268418312,
-0.012095815502107143,
0.025366563349962234,
0.15817220509052277,
-0.02275526337325573,
0.01773747242987156,
0.1043904721736908,
-0.006285242270678282,
0.054561033844947815,
0.15091851353645325,
-0.06764248758554459,
-0.16778428852558136,
-0.009583896957337856,
0.07635272294282913,
0.026746906340122223,
0.3837583065032959,
-0.12065202742815018,
0.08861377090215683,
-0.10942534357309341,
0.08322067558765411,
0.08182720839977264,
-0.19537580013275146,
-0.03969469666481018,
0.2015949785709381,
-0.2545277178287506,
0.09697389602661133,
-0.19705066084861755,
-0.1945302039384842,
-0.25410306453704834,
0.16042600572109222,
-0.0952686294913292,
0.12922202050685883,
0.11612682044506073,
0.07108262181282043,
-0.11124482750892639,
0.11908695101737976,
0.011241511441767216,
0.11420351266860962,
-0.10419190675020218,
-0.28649330139160156,
-0.1941431313753128,
0.19564780592918396,
0.01105657871812582,
0.21656952798366547,
-0.21396967768669128,
-0.12048991024494171,
0.10402050614356995,
-0.05928395688533783,
-0.1556592434644699,
0.19047212600708008,
0.04805236682295799,
-0.016168667003512383,
0.06120988354086876,
-0.01762520521879196,
-0.009726393967866898,
-0.26119208335876465,
0.053185056895017624,
0.18671508133411407,
-0.20036998391151428,
-0.21318291127681732,
0.17130891978740692,
0.20823714137077332,
0.07228980213403702,
-0.004516636487096548,
0.18197213113307953,
0.32595956325531006,
0.22859205305576324,
0.13541077077388763,
-0.33790120482444763,
-0.26359936594963074,
-0.050460267812013626,
0.08337019383907318,
0.070024773478508,
-0.23912154138088226,
0.024613987654447556,
0.15499600768089294,
0.0814419835805893,
0.08764206618070602,
-0.14657674729824066,
0.04686437547206879,
0.1387520432472229,
0.028974657878279686,
0.21873220801353455,
-0.08836966753005981,
0.01364720519632101,
-0.056181032210588455,
-0.10640359669923782,
-0.03673248365521431,
0.3080347776412964,
0.01622873730957508,
-0.2368861436843872,
0.3213624656200409,
0.11565521359443665,
-0.07100360840559006,
-0.053625959903001785,
0.2057468444108963,
0.18385930359363556,
-0.13383415341377258,
0.12735924124717712,
0.25925004482269287,
-0.00591700803488493,
0.03944253548979759,
0.28192856907844543,
-0.09980910271406174,
0.11041697859764099,
0.0014947510790079832,
-0.04298066720366478,
0.03736986592411995,
0.10929553210735321,
-0.004114591516554356,
-0.09811665862798691,
0.11793051660060883,
-0.12161967903375626,
-0.1013050228357315,
-0.19541791081428528,
-0.0023116166703402996,
0.12484416365623474,
0.09817531704902649,
0.04536404088139534,
0.004019328858703375,
-0.024365102872252464,
0.26150673627853394,
0.247775137424469,
-0.032236095517873764,
-0.01629752852022648,
-0.1122552752494812,
-0.007247549947351217,
0.11300235241651535,
0.016966521739959717,
0.09352774918079376,
0.09901160001754761,
0.1897803395986557,
-0.03630758076906204,
0.03781833127140999,
0.015315434895455837,
0.2325422465801239,
-0.05027264729142189,
-0.12769551575183868,
0.11324083805084229,
0.025495151057839394,
-0.06365613639354706,
-0.19102703034877777,
-0.11407572031021118,
0.009501278400421143,
-0.1020037904381752,
-0.23821362853050232,
-0.23460203409194946,
-0.31435707211494446,
0.04867846891283989,
0.06846147030591965,
-0.08982160687446594,
0.05975382775068283,
0.015041657723486423,
-0.2600833475589752,
-0.009754150174558163,
-0.05536343529820442,
-0.04604564607143402,
-0.16657401621341705,
0.23276269435882568,
-0.04697582125663757,
0.022598130628466606,
-0.09204114973545074,
0.022642184048891068,
-0.030265972018241882,
-0.02542051486670971,
-0.10756774246692657,
0.04599740356206894,
0.023395562544465065,
-0.16374841332435608,
-0.14010344445705414,
-0.198358416557312,
-0.04358935356140137,
-0.021440917626023293,
-0.05228015035390854,
0.24804385006427765,
0.10173097252845764,
-0.0476258248090744,
0.06761480867862701,
0.16627871990203857,
0.015828920528292656,
-0.3969910442829132,
0.029194863513112068,
-0.21301567554473877,
-0.27489158511161804,
-0.05445237457752228,
0.05027445778250694,
0.0836561843752861,
-0.04664751514792442,
-0.05383802950382233,
-0.07797418534755707,
-0.16761183738708496,
0.37445348501205444,
0.052138496190309525,
-0.2257619947195053,
0.19169488549232483,
0.06462375819683075,
-0.0614362508058548,
0.16048859059810638,
0.019001731649041176,
-0.02514873631298542,
0.1542694866657257,
-0.2134023755788803,
-0.3150654435157776,
0.211580291390419,
0.01842690259218216,
0.0941968709230423,
-0.005021553952246904,
0.11065445840358734,
0.1608605682849884,
0.11067285388708115,
-0.10876677930355072,
0.031182056292891502,
0.007363797165453434,
0.3861933648586273,
-0.16188576817512512,
0.057852279394865036,
-0.17314749956130981,
-0.12515319883823395,
-0.10712047666311264,
-0.249095156788826,
0.032863322645425797,
-0.04949270188808441,
0.019277697429060936,
-0.1011551022529602,
0.14161933958530426,
-0.1363198608160019,
0.11490712314844131,
-0.09099378436803818,
-0.2064056247472763,
-0.03832152858376503,
0.05117770656943321,
-0.11614280939102173,
-0.12588784098625183,
0.24333086609840393,
0.11503972113132477,
-0.11175623536109924,
-0.3635658621788025,
0.16612078249454498,
-0.06553477793931961,
0.21405191719532013,
-0.051665134727954865,
-0.038616959005594254,
0.10924334824085236,
-0.016736654564738274,
0.13932430744171143,
0.15621960163116455,
0.08327244222164154,
-0.05290943756699562,
-0.03532211482524872,
0.1742534339427948,
0.007830047979950905,
0.02909751981496811,
0.09146717935800552,
0.13565389811992645,
0.017957082018256187,
0.03769546374678612,
0.08915088325738907,
0.05937958136200905,
0.003281185869127512,
0.07076708227396011,
-0.09088220447301865,
0.03341938182711601,
-0.12500552833080292,
-0.01717068813741207,
0.053872089833021164,
0.04275870695710182,
0.3812926709651947,
-0.21252773702144623,
-0.02407749928534031,
-0.018064046278595924,
-0.25847047567367554,
0.007895096205174923,
0.135713592171669,
-0.1331973820924759,
0.013417490758001804,
-0.0019081414211541414,
-0.038307733833789825,
-0.13024793565273285,
-0.014328863471746445,
0.0637851431965828,
0.016691353172063828,
0.021787263453006744,
-0.17716774344444275,
0.08298426866531372,
0.09676326811313629,
0.07442829012870789,
-0.05680035427212715,
-0.14012977480888367,
0.028300834819674492,
0.10186329483985901,
-0.09545600414276123,
-0.053046345710754395,
0.1018364429473877,
-0.22063875198364258,
0.10322342067956924,
-0.07690200954675674,
-0.03883067145943642,
0.43942293524742126,
0.13783156871795654,
-0.08444858342409134,
0.11540628224611282,
0.1378045529127121,
-0.03371525928378105,
-0.13066896796226501,
0.17335563898086548,
-0.008389931172132492,
-0.14170683920383453,
0.13101962208747864,
0.059254538267850876,
-0.06470464915037155,
0.02737009897828102,
-0.3579307794570923,
-0.043225374072790146,
-0.014497166499495506,
0.0800110474228859,
-0.1287025362253189,
-0.09919293969869614,
-0.2393278032541275,
0.015244154259562492,
-0.04197941720485687,
0.027575325220823288,
-0.09360581636428833,
0.19705595076084137,
0.029198812320828438,
-0.017832141369581223,
-0.14087174832820892,
0.2168448120355606,
-0.07085197418928146,
-0.13949468731880188,
-0.1496213674545288,
-0.09651235491037369,
0.11939098685979843,
-0.11045721173286438,
-0.2720594108104706,
-0.05882633477449417,
0.048235636204481125,
0.037277814000844955,
0.02055387571454048,
-0.012214499525725842,
-0.04851299896836281,
-0.006897299084812403,
-0.19043025374412537,
-0.05966104567050934,
0.06645049154758453,
-0.14953094720840454,
0.30765557289123535,
-0.012754198163747787,
-0.06225013732910156,
-0.08385956287384033,
-0.02593112550675869,
-0.010780061595141888,
0.20855975151062012,
0.021666761487722397,
0.14301122725009918,
0.11805003136396408,
0.14189213514328003,
0.0970359817147255,
-0.19162675738334656,
0.00805332325398922,
0.04729188606142998,
0.032855190336704254,
0.14606638252735138,
-0.1695043295621872,
0.2536650598049164,
-0.04360432177782059,
0.18238191306591034,
0.11249600350856781,
0.0597241148352623,
0.019720733165740967,
0.13944710791110992,
0.23075343668460846,
0.0010366726201027632,
-0.02132893167436123,
0.02685445174574852,
-0.14451278746128082,
-0.03199375420808792,
0.09925436228513718,
-0.004036964848637581,
0.08413733541965485,
0.017269717529416084,
-0.21183395385742188,
-0.05961854010820389,
-0.21647074818611145,
0.25094419717788696,
0.10432334244251251,
-0.14241190254688263,
0.002581097884103656,
-0.19145013391971588,
-0.03910519927740097,
0.18406343460083008,
-0.23034442961215973,
0.05785035341978073,
0.43516939878463745,
0.13604198396205902,
0.0016225421568378806,
0.005332564935088158,
0.050320517271757126,
0.06450651586055756,
0.006354043725878,
0.05850209295749664,
0.20615260303020477,
-0.12195039540529251,
0.09115578979253769,
0.08211435377597809,
0.17229802906513214,
-0.03190816938877106,
-0.07660753279924393,
-0.1510223001241684,
0.08324628323316574,
-0.1386553943157196,
0.015571574680507183,
-0.28462815284729004,
0.019376806914806366,
0.04172488674521446,
-0.1796896755695343,
0.03365897759795189,
0.03961760178208351,
-0.02424309402704239,
0.19392400979995728,
-0.21931235492229462,
-0.06852559745311737,
0.11374484747648239,
0.28971803188323975,
0.011274541728198528,
0.3786610960960388,
-0.060433097183704376,
0.12575438618659973,
-0.3453480303287506,
0.001081670168787241,
0.07000821083784103,
-0.0924314558506012,
0.0015187776880338788,
0.07746034115552902,
0.1901090443134308,
0.1922372430562973,
0.000027672665964928456,
0.0275570135563612,
0.10914982110261917,
0.0019554877653717995,
0.01295106764882803,
0.2435888797044754,
-0.0856604054570198,
-0.0018768834415823221,
-0.0057604145258665085,
0.1319427341222763,
0.12433556467294693,
0.17538948357105255,
0.09239353239536285,
-0.3385734260082245,
0.1538575440645218,
-0.14832191169261932,
0.0004566218995023519,
-0.28629425168037415,
-0.3814331293106079,
-0.23533816635608673,
0.10771182924509048,
0.01134931668639183,
0.04454518109560013,
-0.04556538164615631,
-0.06726530939340591,
0.05303284153342247,
-0.0019337561680004,
0.011781741864979267,
0.040227897465229034,
-0.1296273171901703,
0.19934546947479248,
-0.14383119344711304,
0.11369135230779648,
-0.05219750106334686,
0.16200260818004608,
0.04277386888861656,
0.07454744726419449,
-0.13688020408153534,
-0.06587214022874832,
-0.2952524423599243,
0.04562553018331528,
0.2003050148487091,
-0.0855807289481163,
0.04871201515197754,
-0.06893586367368698,
0.2889575958251953,
-0.22843454778194427,
0.09765181690454483,
0.39997735619544983,
-0.21191327273845673,
-0.04123656451702118,
-0.20662041008472443,
-0.10211799293756485,
0.08121822029352188,
0.10730795562267303,
0.07036181539297104,
0.048645082861185074,
0.05413051322102547,
0.07037020474672318,
0.004476684611290693,
0.029087230563163757,
0.08211368322372437,
-0.02586839348077774,
-0.16553066670894623,
-0.27747786045074463,
0.363345742225647,
0.09124100208282471,
-0.12764522433280945,
0.030236979946494102,
-0.22095772624015808,
0.06763697415590286,
-0.046139366924762726,
0.031017016619443893,
0.13048110902309418,
0.027344394475221634,
0.1297580748796463,
-0.2142544537782669,
-0.14340683817863464,
-0.14745666086673737,
0.13511432707309723,
-0.14125514030456543,
0.23229676485061646,
0.33616316318511963,
0.16106195747852325,
0.14882491528987885,
-0.19335034489631653,
-0.0008847616845741868,
-0.2652077078819275,
0.03484524413943291,
0.003935521002858877,
0.0385545939207077,
0.13441437482833862,
0.026126429438591003,
0.10883532464504242,
-0.010374720208346844,
-0.0032837858889251947,
0.0725841373205185,
0.3129854202270508,
0.16670091450214386,
-0.014735768549144268,
-0.11746454983949661,
-0.11626630276441574,
-0.10610485076904297,
-0.034370824694633484,
-0.04142181575298309,
0.07835980504751205,
0.014925088733434677,
-0.0991225615143776,
-0.42054301500320435,
0.016904357820749283,
0.02202977053821087,
-0.02071831375360489,
0.15651892125606537,
0.19914595782756805,
-0.15389057993888855,
0.05948387831449509,
0.03432256355881691,
0.11398573219776154,
0.16579245030879974,
-0.06290380656719208,
0.19521798193454742,
0.08373686671257019,
0.15460321307182312,
-0.006314147729426622,
-0.24012230336666107,
-0.041336286813020706,
-0.20882262289524078,
-0.05153525620698929,
0.09051915258169174,
-0.14022071659564972,
-0.26153942942619324,
-0.00872640311717987,
-0.11511638015508652,
-0.1525420844554901,
0.04318058490753174,
0.053960125893354416,
-0.0791269913315773
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. 20 years .Most affected individuals have little or no manifestations at birth. Most typically, the first manifestations of the disorder occur between age six and 18 months with the onset of asymmetric overgrowth; it is most commonly of the feet or hands but may occur anywhere. An exception is that a few (probably <5%) first manifest PS with hemimegencephaly, often associated with CNS migration defects and later intellectual disability. This manifestation is prenatal. In most other affected individuals, the congenital manifestations are so subtle as to be discounted or missed. These include subtle degrees of asymmetry or faint linear nevi.Overgrowth. The overgrowth in PS can be startling in its severity and rapidity of progression in contrast to most segmental overgrowth disorders. The overgrowth in individuals with PS is, for most parts of the skeleton (except congenital hemimegencephaly), absent or minimal at birth, does not typically manifest until age six to 18 months, and has had its onset | [
-0.026006106287240982,
-0.2741605341434479,
0.10252208262681961,
-0.2370007187128067,
0.09151710569858551,
-0.14456623792648315,
-0.017546694725751877,
-0.18060849606990814,
-0.046351633965969086,
0.2165922373533249,
0.09666203707456589,
0.1482153832912445,
0.13453309237957,
0.07708476483821869,
-0.1943879872560501,
-0.10284128785133362,
-0.08060292899608612,
-0.09883464127779007,
-0.159556582570076,
0.09154827147722244,
0.045774951577186584,
-0.14469581842422485,
-0.016722360625863075,
0.14436380565166473,
0.06445463746786118,
-0.09521244466304779,
0.18598684668540955,
0.05102773755788803,
-0.038603853434324265,
-0.13539975881576538,
-0.01517864316701889,
-0.0902528390288353,
-0.0437680222094059,
-0.12737855315208435,
0.1885910928249359,
-0.14623375236988068,
-0.19356127083301544,
-0.08176781982183456,
0.2582648694515228,
0.013861620798707008,
-0.05781795084476471,
0.22622449696063995,
-0.14829452335834503,
-0.12225612252950668,
0.25876566767692566,
-0.07008297741413116,
-0.05744362995028496,
0.13999301195144653,
0.11937311291694641,
0.08927187323570251,
0.19845080375671387,
-0.03408273681998253,
0.1744047850370407,
-0.040242765098810196,
0.21452799439430237,
-0.13933049142360687,
-0.028866345062851906,
-0.12659873068332672,
-0.3422994017601013,
0.06830044835805893,
0.20643486082553864,
-0.13769520819187164,
0.17646154761314392,
-0.4212369918823242,
0.02509717270731926,
-0.39364731311798096,
-0.08184152841567993,
0.16306699812412262,
-0.06687280535697937,
0.13614539802074432,
0.25154978036880493,
-0.29895737767219543,
-0.42783060669898987,
-0.10311438143253326,
-0.2367294877767563,
-0.11063862591981888,
0.10691011697053909,
-0.1184251680970192,
-0.08239167183637619,
-0.06848456710577011,
0.16150937974452972,
0.11915058642625809,
-0.10522416234016418,
0.23400184512138367,
-0.08683733642101288,
-0.04053429886698723,
0.12634243071079254,
0.10907992720603943,
-0.02486812323331833,
0.029480913653969765,
0.14316023886203766,
-0.16912610828876495,
0.10746688395738602,
0.07624989748001099,
0.4070194661617279,
-0.004023716319352388,
0.13528865575790405,
-0.08159666508436203,
-0.1585616171360016,
0.013065648265182972,
0.14059396088123322,
0.39170318841934204,
-0.012156934477388859,
-0.08975271135568619,
0.07872709631919861,
-0.16835612058639526,
-0.1569085717201233,
0.2532768249511719,
0.11364905536174774,
0.1038159504532814,
-0.1406717449426651,
-0.2999739944934845,
-0.03069952502846718,
-0.1390186846256256,
-0.22567282617092133,
-0.1647396981716156,
0.007020116783678532,
-0.04256102442741394,
-0.16470104455947876,
-0.11293934285640717,
0.00492448266595602,
-0.09081795811653137,
0.15058794617652893,
0.16539640724658966,
0.16731451451778412,
0.03429458290338516,
0.1555909514427185,
0.01683380827307701,
0.07306068390607834,
-0.1340969055891037,
0.12237245589494705,
-0.048556238412857056,
-0.28216782212257385,
-0.3352459967136383,
0.1871393620967865,
0.06384751945734024,
-0.05976124480366707,
-0.09577372670173645,
0.10284572094678879,
0.04520292580127716,
0.2047480046749115,
0.07087031751871109,
0.41684427857398987,
0.09863868355751038,
0.22351951897144318,
0.03127546235918999,
0.12401719391345978,
0.2499392181634903,
0.143402099609375,
-0.19432766735553741,
0.2665584683418274,
-0.1633489578962326,
0.13715225458145142,
-0.09216581284999847,
0.024984177201986313,
-0.015398207120597363,
0.09803326427936554,
-0.1469792276620865,
-0.058468855917453766,
-0.11368434876203537,
0.0024421534035354853,
-0.08646385371685028,
0.03025010973215103,
-0.2065882384777069,
-0.2717825770378113,
-0.003034689463675022,
-0.03239482641220093,
-0.2886688709259033,
0.03512534871697426,
-0.11280684173107147,
-0.04217969626188278,
0.05970899015665054,
-0.21005229651927948,
0.0005961882416158915,
-0.04136211425065994,
0.06989859789609909,
0.03994731232523918,
0.07873175293207169,
-0.04095996543765068,
0.2208845168352127,
0.01625254563987255,
0.006090541370213032,
0.10046040266752243,
-0.23489125072956085,
-0.07479843497276306,
-0.21123234927654266,
0.04548538848757744,
0.23505334556102753,
-0.17442473769187927,
-0.011706617660820484,
0.1101350262761116,
0.06473324447870255,
-0.0015329386806115508,
0.06101971119642258,
-0.09614667296409607,
-0.2477797269821167,
0.01879490353167057,
-0.01825815811753273,
0.1500023901462555,
0.1348644345998764,
0.17048637568950653,
-0.030537325888872147,
0.18108104169368744,
-0.005187787115573883,
0.08248739689588547,
0.0642111673951149,
-0.009656702168285847,
-0.0941188633441925,
0.09899242222309113,
0.11997804045677185,
-0.13933861255645752,
0.30725187063217163,
-0.05249959975481033,
0.08216536045074463,
0.01878933794796467,
-0.04531627893447876,
0.03721195086836815,
-0.17192544043064117,
-0.030451318249106407,
0.181010901927948,
-0.22458523511886597,
0.07159692794084549,
-0.2862313687801361,
-0.023821016773581505,
-0.32667776942253113,
0.07612072676420212,
-0.19763386249542236,
-0.15049970149993896,
0.12121319025754929,
-0.028475411236286163,
-0.13292661309242249,
-0.06446746736764908,
-0.059530824422836304,
0.22266851365566254,
-0.038386330008506775,
-0.26088035106658936,
-0.11797598749399185,
0.21560168266296387,
-0.05153137445449829,
0.2667888402938843,
-0.09744647145271301,
-0.2400864064693451,
0.10534370690584183,
-0.09915611147880554,
-0.15644122660160065,
0.05099988356232643,
-0.03294611722230911,
0.012894238345324993,
-0.00636344263330102,
-0.036245182156562805,
0.08686847239732742,
-0.26758646965026855,
0.12844733893871307,
0.14356283843517303,
-0.23231296241283417,
-0.2087651938199997,
0.21779745817184448,
0.05242367088794708,
-0.00040427956264466047,
0.013595298863947392,
0.13801103830337524,
0.36294451355934143,
0.40275147557258606,
-0.10129211097955704,
-0.26886311173439026,
-0.28469568490982056,
-0.08439714461565018,
0.1742563247680664,
0.12898878753185272,
-0.3634687662124634,
-0.046975113451480865,
0.22145961225032806,
0.09084609150886536,
0.03583506867289543,
-0.07277584075927734,
0.028035616502165794,
0.03725014254450798,
-0.0502329058945179,
0.19276916980743408,
-0.024298185482621193,
-0.0049793915823102,
-0.1146995946764946,
-0.06788508594036102,
-0.00270767230540514,
0.39616137742996216,
-0.049143631011247635,
-0.32513976097106934,
0.3060161769390106,
0.05411576107144356,
-0.19476871192455292,
0.002724724356085062,
0.10216125845909119,
0.2099253386259079,
0.03807933256030083,
0.14551664888858795,
0.2503761649131775,
-0.15289314091205597,
0.10136682540178299,
0.315123051404953,
-0.01706821471452713,
0.12844379246234894,
0.1547648161649704,
-0.058243121951818466,
0.008036634884774685,
0.07211463153362274,
-0.05222678557038307,
-0.10422129929065704,
0.015188978984951973,
-0.061823222786188126,
-0.16379669308662415,
-0.10315455496311188,
0.03698278218507767,
0.19726140797138214,
0.09157835692167282,
0.026596305891871452,
-0.015294921584427357,
-0.09533420950174332,
0.18510662019252777,
0.3205852210521698,
0.041337549686431885,
0.009859498590230942,
-0.08037958294153214,
-0.0454096719622612,
0.15571118891239166,
0.06255674362182617,
-0.073859304189682,
0.140764981508255,
0.23254504799842834,
-0.12760354578495026,
0.03248896077275276,
0.02365858294069767,
0.14308716356754303,
-0.02506096102297306,
-0.14289161562919617,
0.123077891767025,
-0.025009918957948685,
-0.06164403259754181,
-0.17877374589443207,
-0.1176588386297226,
-0.042859721928834915,
-0.11374452710151672,
-0.3083445727825165,
-0.1325261890888214,
-0.18002231419086456,
0.0782427191734314,
-0.09910270571708679,
-0.047457676380872726,
0.06383605301380157,
-0.10779005289077759,
-0.17797093093395233,
0.0202092994004488,
-0.016317300498485565,
-0.06235993281006813,
-0.2560962438583374,
0.11726688593626022,
0.06726077198982239,
0.03510987386107445,
-0.0981937050819397,
-0.0484161339700222,
-0.052601706236600876,
-0.07786224037408829,
-0.025687970221042633,
-0.16494272649288177,
0.003257955424487591,
-0.21435114741325378,
-0.05965949222445488,
-0.25981634855270386,
-0.17985178530216217,
0.2097296267747879,
-0.07591382414102554,
0.28976085782051086,
0.037157125771045685,
0.04628844931721687,
-0.05124139040708542,
0.17698028683662415,
0.06342394649982452,
-0.2667904794216156,
0.019399959594011307,
-0.1958073377609253,
-0.33139747381210327,
-0.11953552067279816,
0.16074641048908234,
0.11305873095989227,
-0.12775862216949463,
-0.05214659497141838,
-0.09936613589525223,
-0.15121084451675415,
0.16107329726219177,
0.129240483045578,
-0.2591506540775299,
0.2437623143196106,
0.1487005203962326,
-0.13247331976890564,
0.2856760621070862,
0.1540868729352951,
-0.0731661394238472,
0.019682014361023903,
-0.1254519522190094,
-0.35057342052459717,
0.14851579070091248,
-0.08671282231807709,
0.11646591871976852,
0.14882485568523407,
0.2829236090183258,
0.1405201107263565,
0.08432929217815399,
-0.16922476887702942,
0.15558452904224396,
-0.04405061528086662,
0.27377602458000183,
-0.12172006070613861,
-0.061140600591897964,
-0.20059551298618317,
-0.2421615719795227,
-0.10741539299488068,
-0.25820744037628174,
0.08877400308847427,
-0.14252105355262756,
0.1106705293059349,
-0.17461632192134857,
0.1802443265914917,
-0.24052464962005615,
0.15021288394927979,
0.055874016135931015,
-0.14858843386173248,
-0.1137389987707138,
0.10736840963363647,
0.04420986399054527,
-0.04817090556025505,
0.2500593960285187,
0.2433718740940094,
-0.13617175817489624,
-0.3041265308856964,
0.20051027834415436,
0.018385697156190872,
0.18764184415340424,
-0.06098887696862221,
0.022821616381406784,
0.05805899202823639,
-0.09362035244703293,
0.20437705516815186,
0.10866551846265793,
0.02706320397555828,
-0.12144669890403748,
-0.10799316316843033,
0.24979563057422638,
0.05767008662223816,
0.059603799134492874,
0.03722330182790756,
0.07635067403316498,
0.015632320195436478,
-0.022284433245658875,
0.14526675641536713,
0.11126568913459778,
0.2628968060016632,
0.15535669028759003,
-0.034631624817848206,
0.1751084178686142,
-0.16200897097587585,
-0.10223495960235596,
0.12921640276908875,
0.06311874836683273,
0.32990923523902893,
-0.16102513670921326,
0.05978476628661156,
-0.056552086025476456,
-0.272725909948349,
-0.05586396902799606,
0.1230522021651268,
-0.20265091955661774,
-0.00324517791159451,
0.053014207631349564,
-0.07808849960565567,
-0.10757490992546082,
-0.12817712128162384,
0.01646512746810913,
-0.08121424913406372,
0.06027219444513321,
-0.2684813141822815,
0.13715605437755585,
0.03960372135043144,
0.06682377308607101,
-0.0005647021462209523,
-0.11000651121139526,
-0.026930956169962883,
0.0713731050491333,
-0.08978752046823502,
-0.05952434241771698,
0.1998085081577301,
-0.150343120098114,
0.19111599028110504,
-0.04630475491285324,
-0.0204241331666708,
0.32583850622177124,
0.08539348095655441,
-0.0628361776471138,
0.03554100915789604,
0.18076077103614807,
-0.042922526597976685,
-0.2124127298593521,
0.08589311689138412,
0.06338118761777878,
-0.09247047454118729,
0.020539432764053345,
-0.0376116968691349,
0.14305149018764496,
-0.005655401851981878,
-0.33889544010162354,
-0.0578683465719223,
-0.01358719915151596,
0.1036069393157959,
-0.06240767613053322,
0.04698127880692482,
-0.1855660378932953,
0.027773743495345116,
-0.13917751610279083,
0.04130134731531143,
-0.05402541160583496,
0.004089659079909325,
-0.09591805934906006,
0.020036814734339714,
-0.24536216259002686,
0.17882101237773895,
0.06036031246185303,
-0.04083546623587608,
-0.1275116503238678,
-0.1770874559879303,
0.1465419977903366,
-0.10121140629053116,
-0.24816641211509705,
-0.06630293279886246,
0.011483220383524895,
0.05530553311109543,
0.20978103578090668,
0.13977216184139252,
-0.13865207135677338,
-0.042211636900901794,
-0.08838450908660889,
-0.007299275137484074,
0.07738873362541199,
-0.1361965537071228,
0.3055468499660492,
-0.05041085556149483,
0.11266729980707169,
-0.13808579742908478,
0.05794141814112663,
0.06812527775764465,
0.17916393280029297,
-0.16444703936576843,
0.2644295394420624,
0.19541417062282562,
-0.066938117146492,
0.10492467880249023,
-0.01800367794930935,
0.0353427492082119,
-0.020879361778497696,
0.14263443648815155,
0.050589729100465775,
-0.06695514172315598,
0.3500197231769562,
-0.2163960039615631,
0.004437440074980259,
-0.07619980722665787,
-0.02110331505537033,
-0.011178513988852501,
0.15192300081253052,
0.3362385630607605,
0.11812041699886322,
0.009462356567382812,
-0.007674971595406532,
0.01728302426636219,
0.007447582669556141,
0.1779939830303192,
-0.0024753231555223465,
-0.20583556592464447,
0.11070960760116577,
-0.17812694609165192,
-0.10816950350999832,
-0.24814321100711823,
0.1685902178287506,
0.009976768866181374,
-0.13463889062404633,
-0.12496395409107208,
-0.15364433825016022,
-0.02331589162349701,
0.1644991636276245,
-0.09162052720785141,
-0.054308000952005386,
0.39371630549430847,
0.10995722562074661,
0.02486468106508255,
-0.1432504504919052,
0.08193182200193405,
-0.05690022557973862,
-0.042294636368751526,
0.0727045089006424,
0.09527646750211716,
-0.00520205358043313,
0.11790567636489868,
0.06796610355377197,
0.27517980337142944,
0.013131886720657349,
0.012463929131627083,
-0.10033866763114929,
-0.1068316176533699,
0.09119829535484314,
0.1228472888469696,
-0.26091670989990234,
0.2784845232963562,
0.10201292484998703,
-0.14719648659229279,
-0.07454259693622589,
0.0525289811193943,
-0.017095474526286125,
0.19063399732112885,
-0.2502899467945099,
0.037580765783786774,
-0.009662111289799213,
0.3060242831707001,
0.03890922665596008,
0.4299390912055969,
-0.01746123656630516,
0.10480711609125137,
-0.3109484314918518,
-0.11670754104852676,
0.05850806459784508,
-0.07187796384096146,
-0.056310173124074936,
0.09004631638526917,
0.09091538935899734,
0.07345876842737198,
-0.0691709890961647,
-0.02540845051407814,
0.05043124407529831,
0.07557843625545502,
0.09796606004238129,
0.3202178478240967,
-0.012948469258844852,
-0.11042237281799316,
-0.16231128573417664,
0.1354006975889206,
-0.09023529291152954,
0.16745959222316742,
0.12409225851297379,
-0.30496877431869507,
0.07646661251783371,
-0.18114058673381805,
-0.021805744618177414,
-0.34845712780952454,
-0.32915687561035156,
-0.1666857749223709,
0.14021791517734528,
0.00665418291464448,
0.03537563979625702,
0.06504937261343002,
0.07738178968429565,
-0.024522971361875534,
-0.16913162171840668,
0.13744617998600006,
0.04155859723687172,
-0.07001979649066925,
0.2605591416358948,
-0.060989584773778915,
-0.007183997426182032,
-0.0042044660076498985,
0.20822840929031372,
0.1527864784002304,
0.12409569323062897,
-0.024617508053779602,
-0.06959691643714905,
-0.3884902894496918,
0.036438532173633575,
0.2705693542957306,
-0.10209579765796661,
0.08009782433509827,
0.06317630410194397,
0.17929765582084656,
-0.14753083884716034,
0.18879783153533936,
0.4111810028553009,
-0.1295592337846756,
-0.11856532096862793,
-0.27037033438682556,
-0.17904414236545563,
0.12592625617980957,
0.1841486543416977,
0.056220319122076035,
0.06872085481882095,
0.1330277919769287,
-0.014026188291609287,
0.11254823207855225,
-0.03606913611292839,
0.08175621926784515,
-0.09844402223825455,
-0.1684163361787796,
-0.27888116240501404,
0.4027084410190582,
0.0795070230960846,
-0.15057872235774994,
0.051124151796102524,
-0.2005479484796524,
0.21324168145656586,
-0.013057754375040531,
0.0782347321510315,
0.16585128009319305,
0.06176016107201576,
0.12779705226421356,
-0.2791917622089386,
-0.10292166471481323,
-0.16423100233078003,
0.17920748889446259,
0.03273956850171089,
0.15441887080669403,
0.36005184054374695,
0.09248675405979156,
0.07566392421722412,
-0.16107061505317688,
0.01240591611713171,
-0.24915751814842224,
-0.0005722921341657639,
0.03628172725439072,
0.0020501494873315096,
0.07031573355197906,
-0.13885462284088135,
0.1635054051876068,
-0.09292551130056381,
-0.012199717573821545,
0.08279818296432495,
0.15306422114372253,
0.09602396935224533,
-0.020566992461681366,
-0.08669228851795197,
-0.22653953731060028,
-0.030100692063570023,
0.11214123666286469,
-0.02397199720144272,
0.06451323628425598,
0.05083129182457924,
-0.1647307276725769,
-0.3061027526855469,
0.05698513239622116,
0.04322553798556328,
0.030329890549182892,
0.10018141567707062,
0.14292782545089722,
-0.12801769375801086,
0.034504760056734085,
0.08076445013284683,
0.21966591477394104,
0.0653996467590332,
-0.005575736053287983,
0.14166291058063507,
0.0965379849076271,
0.12645891308784485,
-0.022159220650792122,
-0.10308932512998581,
-0.16067957878112793,
-0.19697967171669006,
-0.1583438217639923,
0.09995997697114944,
-0.23109711706638336,
-0.33865800499916077,
0.08155994117259979,
0.0003146382514387369,
-0.06952709704637527,
0.13434234261512756,
0.11381416767835617,
-0.05951394885778427
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. affected individuals, the congenital manifestations are so subtle as to be discounted or missed. These include subtle degrees of asymmetry or faint linear nevi.Overgrowth. The overgrowth in PS can be startling in its severity and rapidity of progression in contrast to most segmental overgrowth disorders. The overgrowth in individuals with PS is, for most parts of the skeleton (except congenital hemimegencephaly), absent or minimal at birth, does not typically manifest until age six to 18 months, and has had its onset as late as age 12 years. The typical progression of an area of overgrowth in an individual with PS is 15% larger at age one year, 30% larger at three years, and 100% larger at age six years. On plain radiographs the bones affected by PS, especially the tubular bones of the limbs, the vertebral bodies, and the skull, develop distorting, bizarre, irregular calcified overgrowth that can render the bone unrecognizable with time. The rapid and | [
0.05320284143090248,
-0.28649795055389404,
-0.05032588168978691,
-0.21402059495449066,
0.05580075830221176,
-0.16386468708515167,
-0.042792338877916336,
-0.31441402435302734,
-0.09737271815538406,
0.1230175644159317,
0.11793085932731628,
0.16499987244606018,
-0.010906364768743515,
0.11897241324186325,
-0.18764567375183105,
0.09818445146083832,
-0.07156133651733398,
-0.1420179009437561,
-0.09048277884721756,
0.10542666167020798,
0.02685065008699894,
-0.04371614754199982,
-0.013174465857446194,
0.17536568641662598,
0.06890997290611267,
-0.000265049486188218,
0.16635872423648834,
0.14301903545856476,
0.08023316413164139,
0.014096492901444435,
-0.10044078528881073,
-0.19116373360157013,
0.03646024689078331,
-0.32097235321998596,
0.308031290769577,
-0.30392029881477356,
-0.19539956748485565,
-0.04750489816069603,
0.15343189239501953,
0.09705152362585068,
-0.07889976352453232,
0.2653057873249054,
-0.06513680517673492,
-0.11446619033813477,
0.19218868017196655,
-0.043045829981565475,
-0.15234236419200897,
0.11062047630548477,
0.058270569890737534,
0.2179328352212906,
0.12481274455785751,
0.1207338199019432,
0.14555437862873077,
-0.011574901640415192,
0.0011954109650105238,
-0.2319697141647339,
-0.06546063721179962,
-0.04584562033414841,
-0.28641900420188904,
0.0704781785607338,
0.12310942262411118,
-0.12396097183227539,
0.0701778382062912,
-0.29383471608161926,
0.045051176100969315,
-0.27761438488960266,
-0.13204970955848694,
0.24174416065216064,
0.06761174649000168,
0.17968572676181793,
0.3012154996395111,
-0.2828811705112457,
-0.37586939334869385,
-0.04478364437818527,
-0.12325619161128998,
-0.2913654148578644,
0.08641031384468079,
-0.1933552622795105,
-0.07435130327939987,
-0.09711240231990814,
0.11194249987602234,
-0.042503371834754944,
-0.27044495940208435,
0.0167625080794096,
-0.20663665235042572,
-0.03521159291267395,
0.024011807516217232,
0.05798713490366936,
0.02290521375834942,
0.02966390922665596,
0.16837361454963684,
-0.011532844975590706,
0.15589217841625214,
0.1641009896993637,
0.20583203434944153,
0.04563543573021889,
0.1273326575756073,
-0.13504019379615784,
-0.11438777297735214,
-0.07134419679641724,
0.13677413761615753,
0.30966445803642273,
-0.033042289316654205,
-0.027838438749313354,
0.02276812680065632,
-0.15482136607170105,
-0.13004650175571442,
0.23726940155029297,
0.1382376104593277,
0.06319978833198547,
-0.03218842297792435,
-0.25368431210517883,
-0.09456050395965576,
-0.007567822001874447,
-0.3431726098060608,
-0.08970922231674194,
0.04595082998275757,
-0.08203645795583725,
-0.1333293914794922,
-0.25612786412239075,
-0.05782100930809975,
-0.10380863398313522,
-0.0057684131897985935,
0.03787831589579582,
0.19990386068820953,
0.07437559962272644,
0.3794462978839874,
-0.13291919231414795,
0.00069313810672611,
-0.1118258386850357,
0.1234072744846344,
-0.04784853383898735,
-0.0851583406329155,
-0.29493892192840576,
0.26364850997924805,
0.12092618644237518,
-0.11487570405006409,
-0.12054145336151123,
0.11841371655464172,
-0.0454222708940506,
0.20106475055217743,
0.09905759990215302,
0.3821689784526825,
0.2263883352279663,
0.2819785475730896,
0.10147538781166077,
0.11051628738641739,
0.06345576792955399,
0.14998550713062286,
-0.20580293238162994,
0.17373554408550262,
-0.15063650906085968,
0.0548047237098217,
0.037486057728528976,
-0.0009318463853560388,
-0.03254980221390724,
0.08103068917989731,
0.038110099732875824,
0.05698039010167122,
-0.15245012938976288,
-0.046147823333740234,
-0.11680079251527786,
-0.030056554824113846,
-0.30151814222335815,
-0.19314780831336975,
0.08760422468185425,
0.0867871642112732,
-0.12729573249816895,
0.14534291625022888,
-0.09648594260215759,
-0.03614773973822594,
0.06750505417585373,
-0.33049261569976807,
-0.07142149657011032,
-0.025636354461312294,
-0.012412306852638721,
0.1689833402633667,
0.16877032816410065,
-0.0881425216794014,
0.29976335167884827,
0.14225783944129944,
0.061857108026742935,
0.038889095187187195,
-0.07267150282859802,
-0.013633682392537594,
-0.14801152050495148,
-0.04270445555448532,
0.1671174317598343,
-0.06701792031526566,
0.052080489695072174,
0.07046731561422348,
-0.025313036516308784,
-0.002276203129440546,
-0.042063187807798386,
-0.037806589156389236,
-0.297019898891449,
-0.08201228082180023,
0.07628252357244492,
0.08477763086557388,
0.21553543210029602,
0.04176988825201988,
-0.0077950130216777325,
0.16289179027080536,
-0.021621713414788246,
0.10824888199567795,
0.09174805134534836,
-0.004200714640319347,
-0.09739694744348526,
0.09553686529397964,
0.010597800835967064,
-0.20474353432655334,
0.31932029128074646,
-0.06420450657606125,
-0.02171747200191021,
0.09992392361164093,
-0.019504738971590996,
-0.14117608964443207,
-0.17452183365821838,
-0.18265116214752197,
0.17964541912078857,
-0.07649390399456024,
0.2212572991847992,
-0.3150240182876587,
-0.03561852127313614,
-0.3387056589126587,
0.11988750845193863,
-0.03129350021481514,
-0.012406198307871819,
0.10676934570074081,
0.07915370911359787,
-0.18936355412006378,
-0.06584365665912628,
-0.08444522321224213,
0.23340068757534027,
-0.012726092711091042,
-0.18624763190746307,
-0.04040209949016571,
0.18621642887592316,
-0.032449763268232346,
0.21253518760204315,
-0.05523008853197098,
-0.18454089760780334,
0.20430532097816467,
-0.09831447154283524,
-0.12738968431949615,
0.07287099957466125,
-0.0011207052739337087,
-0.020468486472964287,
0.011668129824101925,
0.031467366963624954,
0.06562410295009613,
-0.3034960925579071,
0.17485052347183228,
0.10815466940402985,
-0.1934075653553009,
-0.08242136985063553,
0.1324092447757721,
-0.10193236917257309,
0.10293906182050705,
-0.006676020100712776,
0.052635613828897476,
0.3040708005428314,
0.35853296518325806,
-0.11842649430036545,
-0.20921868085861206,
-0.37568914890289307,
-0.07982277125120163,
0.28966420888900757,
0.033003076910972595,
-0.383456289768219,
-0.07187119871377945,
0.10096637904644012,
0.23922139406204224,
0.021201269701123238,
-0.0378175787627697,
0.14595568180084229,
0.13729585707187653,
-0.10875623673200607,
0.1235886886715889,
0.0931527316570282,
0.1528826355934143,
-0.004729071632027626,
-0.06373386085033417,
0.003856406081467867,
0.35520902276039124,
-0.043265316635370255,
-0.3988805413246155,
0.34803861379623413,
0.03735993057489395,
-0.10129977017641068,
0.03302033245563507,
0.05370069667696953,
0.1616431474685669,
0.06776801496744156,
0.13517524302005768,
0.21961133182048798,
-0.10498232394456863,
-0.11190765351057053,
0.22222472727298737,
-0.09960295259952545,
0.1791003942489624,
0.24965611100196838,
-0.12353616952896118,
0.14056387543678284,
-0.08591573685407639,
-0.024905692785978317,
0.06600283831357956,
-0.0008565793395973742,
0.014758739620447159,
-0.13296285271644592,
-0.06533368676900864,
0.022716108709573746,
0.17748171091079712,
0.0692284107208252,
0.023086396977305412,
0.14971880614757538,
-0.05556227266788483,
0.09281904250383377,
0.26165449619293213,
-0.03970233350992203,
0.09379641711711884,
-0.11799410730600357,
0.014534243382513523,
0.10600125789642334,
0.04737915098667145,
0.09022419899702072,
0.09518276900053024,
0.24624454975128174,
-0.18328721821308136,
0.027521105483174324,
0.017337623983621597,
0.12863177061080933,
-0.10805759578943253,
-0.19873547554016113,
0.11466202884912491,
0.08120384067296982,
-0.14227154850959778,
0.06991024315357208,
0.0895405039191246,
0.02874581329524517,
-0.05905576050281525,
-0.2518647611141205,
-0.0566839799284935,
-0.13625189661979675,
0.11396241933107376,
-0.02828819490969181,
0.020723992958664894,
0.1798972487449646,
-0.0114516019821167,
-0.09320327639579773,
0.021403394639492035,
-0.16745281219482422,
-0.0717225968837738,
-0.40406516194343567,
0.08559096604585648,
0.08542439341545105,
0.10568766295909882,
-0.04442155733704567,
0.00618444150313735,
-0.011972568929195404,
-0.07522377371788025,
-0.0025871603284031153,
-0.3038189113140106,
-0.015600274316966534,
-0.1665380746126175,
-0.06821352988481522,
-0.20387591421604156,
-0.025905856862664223,
0.15559329092502594,
-0.08421244472265244,
0.20826999843120575,
-0.08962614089250565,
0.10373962670564651,
-0.08984693139791489,
0.05689573287963867,
0.09921691566705704,
-0.16928106546401978,
0.013003090396523476,
-0.25165051221847534,
-0.2974136173725128,
-0.1708768904209137,
0.15972651541233063,
0.0006162632489576936,
-0.12413837760686874,
-0.02040998451411724,
-0.024195557460188866,
-0.196202352643013,
0.05006194859743118,
0.06190885230898857,
-0.2684575915336609,
0.21635957062244415,
0.061525821685791016,
0.031338974833488464,
0.29698923230171204,
0.07041244953870773,
-0.039415352046489716,
-0.00922985840588808,
-0.15403108298778534,
-0.20258699357509613,
0.01200549304485321,
0.07273170351982117,
0.13304664194583893,
0.2430463433265686,
0.1893981695175171,
0.04809557646512985,
0.09674055874347687,
-0.06944293528795242,
0.03507133573293686,
-0.1942240446805954,
0.3761559724807739,
-0.2726213037967682,
-0.10977793484926224,
-0.12697745859622955,
-0.20101812481880188,
-0.032454073429107666,
-0.14884570240974426,
0.06117068976163864,
-0.05453677102923393,
0.16231079399585724,
-0.23629313707351685,
0.09084862470626831,
-0.2428310513496399,
0.1944291740655899,
0.025652972981333733,
-0.31986287236213684,
-0.022542573511600494,
-0.08028045296669006,
0.07324458658695221,
-0.10301531106233597,
0.2922777235507965,
0.21916048228740692,
-0.15843383967876434,
-0.1655629277229309,
0.13463649153709412,
0.028131471946835518,
0.03381449356675148,
-0.1712794303894043,
-0.031772807240486145,
0.05144118890166283,
-0.009317096322774887,
0.08007936924695969,
0.01630541682243347,
0.08316843211650848,
0.13692732155323029,
-0.06668664515018463,
0.11851613968610764,
0.0033429062459617853,
-0.00506344111636281,
0.06851927936077118,
0.028105758130550385,
-0.03470490127801895,
-0.11677830666303635,
0.1526152342557907,
0.058149904012680054,
0.3390311002731323,
0.22295965254306793,
-0.13579687476158142,
0.1357932984828949,
-0.21505147218704224,
-0.18291305005550385,
0.02816302888095379,
0.10079097747802734,
0.18295301496982574,
-0.029526010155677795,
0.002334239659830928,
0.04697045311331749,
-0.3423784375190735,
0.02324572019279003,
0.06339100003242493,
-0.1290467381477356,
0.0049547771923244,
0.09076044708490372,
0.01207257341593504,
-0.11208588629961014,
-0.07391515374183655,
0.0181505735963583,
-0.11916195601224899,
0.10568549484014511,
-0.25281786918640137,
0.14951173961162567,
-0.006716190371662378,
0.08884035050868988,
0.026872772723436356,
-0.10139012336730957,
-0.030819350853562355,
0.10571441054344177,
0.0421631820499897,
0.014792939648032188,
0.26231569051742554,
-0.16203252971172333,
0.21256513893604279,
-0.025675253942608833,
0.023999666795134544,
0.3791239559650421,
0.13807007670402527,
0.03124190866947174,
0.10337457060813904,
0.060133546590805054,
0.03755335509777069,
-0.2163025289773941,
0.041934624314308167,
-0.038355469703674316,
-0.031947698444128036,
-0.037527550011873245,
0.04185779392719269,
0.13329631090164185,
-0.04739995673298836,
-0.35442841053009033,
-0.12208187580108643,
0.07076118141412735,
-0.09559503942728043,
-0.06294543296098709,
-0.09973499178886414,
-0.19275866448879242,
0.016689255833625793,
-0.11571632325649261,
0.0057123457081615925,
0.1562652438879013,
-0.023790977895259857,
-0.09939556568861008,
-0.05291902646422386,
-0.1360234022140503,
0.03155054152011871,
0.04737340658903122,
-0.1122685894370079,
-0.04045248031616211,
-0.1713499128818512,
0.18194405734539032,
-0.026248380541801453,
-0.08720559626817703,
-0.07412439584732056,
-0.07365477085113525,
0.11656266450881958,
-0.059115901589393616,
0.25131869316101074,
-0.18514181673526764,
0.0354519747197628,
-0.04857879504561424,
-0.0693911537528038,
0.19326964020729065,
-0.07111465930938721,
0.32514578104019165,
0.0028100060299038887,
0.1921066790819168,
-0.18647122383117676,
0.015107667073607445,
0.11381138116121292,
0.021530628204345703,
-0.0429118312895298,
0.20777632296085358,
0.017174407839775085,
-0.03522730991244316,
-0.03229658678174019,
-0.09659463912248611,
0.11574150621891022,
-0.02948547713458538,
0.20952549576759338,
0.025091970339417458,
-0.02442849799990654,
0.3134053349494934,
-0.12308325618505478,
0.13276545703411102,
-0.027744611725211143,
-0.08142662048339844,
0.08638820797204971,
0.1597209870815277,
0.2942737638950348,
0.03923145309090614,
0.015278098173439503,
-0.012258874252438545,
0.027373293414711952,
0.09041062742471695,
0.30496159195899963,
-0.04477904364466667,
-0.21882423758506775,
0.022121941670775414,
-0.050444893538951874,
-0.10585629940032959,
-0.11058226227760315,
0.156931534409523,
0.19226184487342834,
-0.2641597390174866,
-0.06814310699701309,
-0.19884292781352997,
0.018929392099380493,
0.18902671337127686,
0.06104166805744171,
0.04216798394918442,
0.47718745470046997,
0.07781139761209488,
0.06953272223472595,
-0.025614485144615173,
0.20410166680812836,
-0.060964666306972504,
-0.05881008133292198,
0.018802881240844727,
0.1266176551580429,
-0.04653993621468544,
0.024913471192121506,
0.16656506061553955,
0.41261470317840576,
0.22920238971710205,
-0.06737076491117477,
-0.020146919414401054,
-0.20103810727596283,
0.17168556153774261,
0.10799089074134827,
-0.15578684210777283,
0.35668668150901794,
0.11905927211046219,
-0.12774965167045593,
-0.1581142544746399,
0.14435917139053345,
0.08761994540691376,
0.19304485619068146,
-0.3026537001132965,
0.19746889173984528,
0.03197754546999931,
0.17798210680484772,
-0.030090024694800377,
0.36406248807907104,
-0.12305910140275955,
-0.0037444012705236673,
-0.20273925364017487,
-0.18344873189926147,
0.12532494962215424,
-0.15187664330005646,
-0.09297239780426025,
0.16114863753318787,
0.05910567566752434,
-0.027605848386883736,
-0.05981661006808281,
0.09900493919849396,
0.061036646366119385,
0.14309144020080566,
0.1218138039112091,
0.14325959980487823,
0.13423985242843628,
-0.18269748985767365,
-0.12547481060028076,
-0.08572790026664734,
0.08801300823688507,
0.03432030603289604,
0.05953402444720268,
-0.09028183668851852,
0.0370398610830307,
0.024438023567199707,
-0.1904272437095642,
-0.3567299544811249,
-0.13102202117443085,
-0.13588757812976837,
0.16924764215946198,
-0.1325719952583313,
0.016133563593029976,
0.14465846121311188,
0.007864496670663357,
0.18001553416252136,
-0.2320711612701416,
0.09770289808511734,
0.017700359225273132,
-0.10832225531339645,
0.14412921667099,
0.04978717118501663,
0.011987446807324886,
0.06274967640638351,
0.23432974517345428,
0.0417705774307251,
0.1936800628900528,
-0.031005509197711945,
-0.1667635291814804,
-0.2564411163330078,
0.07801744341850281,
0.1427972912788391,
-0.1403505951166153,
-0.03358680009841919,
0.010731152258813381,
0.14186455309391022,
-0.2056133896112442,
0.14264987409114838,
0.4328456223011017,
-0.08395633846521378,
-0.3843405544757843,
-0.2292705774307251,
-0.28673067688941956,
0.013800124637782574,
0.19724765419960022,
-0.1027008518576622,
0.036827027797698975,
0.0817389115691185,
-0.0692819133400917,
0.03559593856334686,
-0.05518880859017372,
-0.04211404547095299,
-0.014129791408777237,
-0.22831623256206512,
-0.2118651270866394,
0.33723512291908264,
0.12896649539470673,
-0.13466320931911469,
0.026034237816929817,
-0.12319609522819519,
0.1404224932193756,
0.042775221168994904,
-0.07462754100561142,
0.16446571052074432,
-0.004412310663610697,
0.06385333836078644,
-0.3538490831851959,
-0.07700789719820023,
-0.16243794560432434,
0.03096982091665268,
0.0026563447900116444,
0.13173341751098633,
0.34741154313087463,
0.06773822009563446,
0.08664890378713608,
-0.12195878475904465,
0.0032421117648482323,
-0.194809228181839,
-0.075194351375103,
0.12476304918527603,
0.05295056477189064,
0.06031591445207596,
-0.12508751451969147,
0.20179307460784912,
-0.08933678269386292,
-0.10674652457237244,
0.023308292031288147,
0.12444078922271729,
0.016776319593191147,
-0.04925011470913887,
-0.075042724609375,
-0.16476841270923615,
-0.03485669195652008,
0.05077377334237099,
-0.17749324440956116,
0.12221436202526093,
-0.041457388550043106,
-0.2855314612388611,
-0.1419508010149002,
-0.0612788200378418,
0.015799984335899353,
0.04552123695611954,
0.059494856745004654,
0.18452367186546326,
-0.0656159520149231,
0.1503535509109497,
-0.020136946812272072,
0.1542254090309143,
-0.044420111924409866,
0.011850355193018913,
-0.00667561823502183,
0.0824962854385376,
0.16714954376220703,
-0.1395416408777237,
-0.09445241093635559,
-0.2474992275238037,
-0.05520498380064964,
-0.1516846865415573,
0.1374928206205368,
-0.17970529198646545,
-0.38286125659942627,
0.12483865767717361,
0.16623909771442413,
0.066238634288311,
0.16757655143737793,
0.22832058370113373,
0.05183564871549606
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. and has had its onset as late as age 12 years. The typical progression of an area of overgrowth in an individual with PS is 15% larger at age one year, 30% larger at three years, and 100% larger at age six years. On plain radiographs the bones affected by PS, especially the tubular bones of the limbs, the vertebral bodies, and the skull, develop distorting, bizarre, irregular calcified overgrowth that can render the bone unrecognizable with time. The rapid and severe nature of the overgrowth poses a challenge to orthopedic management. It is not uncommon for the overgrowth to accelerate rapidly in childhood, with leg length discrepancies of 20 cm being reported. Scoliotic curves of more than 90° are not uncommon. Any bone can be affected.Many individuals with PS have (often unilateral) overgrowth of the tonsils/adenoids. Splenic overgrowth and asymmetric enlargement of the kidneys and testes are also not uncommon in individuals with PS.Dermatologic findings. Cereb | [
-0.017929518595337868,
-0.25210437178611755,
-0.004522594623267651,
-0.13770174980163574,
0.03675355389714241,
-0.0708567276597023,
0.0035846687387675047,
-0.07104817777872086,
0.011615633964538574,
0.1261162906885147,
0.010775829665362835,
0.25734588503837585,
-0.04449640214443207,
0.15510818362236023,
-0.38118696212768555,
0.13997159898281097,
-0.046797677874565125,
-0.15103840827941895,
-0.09080541133880615,
0.1486067920923233,
-0.1485174596309662,
-0.08208755403757095,
0.005956541746854782,
0.04987970367074013,
0.0313091054558754,
-0.0819413959980011,
0.18508391082286835,
0.22520554065704346,
0.06242382526397705,
0.006063893437385559,
0.03612838685512543,
-0.23307129740715027,
-0.11348456889390945,
-0.36081045866012573,
0.279175728559494,
-0.23670250177383423,
-0.18856991827487946,
-0.06178917735815048,
0.09734996408224106,
-0.007907872088253498,
-0.018987391144037247,
0.20440509915351868,
-0.09661294519901276,
-0.04735776409506798,
0.31099411845207214,
-0.04097241535782814,
-0.26314377784729004,
0.15310567617416382,
0.023706084117293358,
0.02847026102244854,
0.11564980447292328,
0.1893271505832672,
0.16236911714076996,
-0.04169633984565735,
-0.0679258480668068,
-0.32091519236564636,
-0.07517863810062408,
-0.019821694120764732,
-0.3598567247390747,
0.034089818596839905,
0.20406219363212585,
-0.12458399683237076,
0.07954782992601395,
-0.2616107165813446,
-0.07519209384918213,
-0.18726642429828644,
-0.02299986220896244,
0.24326811730861664,
0.130057230591774,
0.1380932629108429,
0.3077607750892639,
-0.23521479964256287,
-0.34948527812957764,
-0.0005344613455235958,
-0.08029085397720337,
-0.23737622797489166,
0.18163394927978516,
-0.16951905190944672,
-0.054660212248563766,
-0.13033252954483032,
0.10600469261407852,
-0.03846416994929314,
-0.3008647561073303,
-0.03784801438450813,
-0.3125145435333252,
-0.1423490047454834,
-0.06625156849622726,
-0.0333002470433712,
0.06329899281263351,
0.035852186381816864,
0.17681829631328583,
-0.15008506178855896,
0.13092215359210968,
0.08417035639286041,
0.09539218246936798,
0.1333460956811905,
0.11470185965299606,
-0.11302398890256882,
-0.08277030289173126,
-0.08793557435274124,
0.016839653253555298,
0.3291611671447754,
-0.08270883560180664,
-0.045672688633203506,
-0.014889420941472054,
-0.1415877491235733,
-0.14128027856349945,
0.21326923370361328,
0.020803606137633324,
-0.03165353462100029,
0.023715851828455925,
-0.14571745693683624,
-0.07794124633073807,
-0.0638054683804512,
-0.38759586215019226,
-0.031345147639513016,
0.07844513654708862,
-0.1812743991613388,
-0.14668428897857666,
-0.4078865051269531,
-0.07283250987529755,
-0.12138588726520538,
0.12458568066358566,
-0.0062532625161111355,
0.23135413229465485,
0.021941762417554855,
0.3662361800670624,
-0.2556180953979492,
0.028146393597126007,
-0.08860595524311066,
0.06378310173749924,
0.0069700428284704685,
-0.05289485305547714,
-0.31507888436317444,
0.1808266043663025,
0.14353536069393158,
-0.23086142539978027,
-0.18804535269737244,
0.209262415766716,
-0.023569274693727493,
0.19096583127975464,
0.0961713194847107,
0.27834734320640564,
0.1565866321325302,
0.2596110999584198,
0.09077265858650208,
0.20326165854930878,
-0.00046938445302657783,
0.13500382006168365,
-0.15732906758785248,
0.3173614740371704,
-0.13398073613643646,
-0.07202672958374023,
0.064005546271801,
-0.05458621308207512,
-0.01779281161725521,
0.05679384991526604,
0.11663547158241272,
0.07036245614290237,
-0.06342759728431702,
-0.06365814805030823,
-0.08591058850288391,
-0.054923489689826965,
-0.41639113426208496,
-0.16697655618190765,
0.07670982927083969,
0.16777819395065308,
-0.16008330881595612,
0.13469956815242767,
-0.10313820838928223,
-0.09844163060188293,
-0.030417080968618393,
-0.2593158185482025,
-0.039376746863126755,
0.012099824845790863,
-0.06973811239004135,
0.28450456261634827,
0.13420218229293823,
-0.1605912744998932,
0.25050726532936096,
0.14388595521450043,
0.10716607421636581,
-0.042525507509708405,
-0.07864522933959961,
-0.10908766090869904,
-0.28126809000968933,
-0.08740255236625671,
0.12038290500640869,
-0.14936673641204834,
0.047418635338544846,
0.16527539491653442,
-0.033286482095718384,
0.0028539004269987345,
-0.13122422993183136,
-0.06360960006713867,
-0.41295403242111206,
0.07821811735630035,
-0.11751663684844971,
0.21058642864227295,
0.1709633618593216,
0.10482319444417953,
-0.06396373361349106,
0.3190469443798065,
0.1267479509115219,
0.013720729388296604,
0.07160453498363495,
0.16791845858097076,
-0.12331750988960266,
0.12930750846862793,
0.07633216679096222,
-0.15779608488082886,
0.24799306690692902,
-0.06322771310806274,
-0.07131475955247879,
0.009271794930100441,
-0.009246792644262314,
-0.1457734853029251,
-0.1997179090976715,
-0.24210835993289948,
0.04881224408745766,
-0.15173394978046417,
0.1283641904592514,
-0.1556563675403595,
-0.08513190597295761,
-0.4145240783691406,
0.05138204246759415,
-0.07174447178840637,
-0.005592190194875002,
-0.14944294095039368,
0.09239189326763153,
-0.25193119049072266,
-0.09237757325172424,
-0.1029973030090332,
0.2086285650730133,
0.03709811344742775,
-0.2739675045013428,
-0.08602483570575714,
0.24090784788131714,
-0.0576007105410099,
0.1690853089094162,
-0.09917549043893814,
-0.11129333823919296,
0.08540251106023788,
-0.17136095464229584,
-0.21455208957195282,
0.17439810931682587,
-0.007804315537214279,
0.023453474044799805,
0.022344080731272697,
-0.054731033742427826,
0.13815031945705414,
-0.19678305089473724,
0.19315119087696075,
0.15495266020298004,
-0.201743945479393,
-0.05093389376997948,
0.10468905419111252,
-0.017098575830459595,
0.03674894571304321,
0.017330270260572433,
-0.07666057348251343,
0.2518408000469208,
0.37918126583099365,
0.05682442709803581,
-0.28232529759407043,
-0.580428421497345,
0.02527441456913948,
0.23312200605869293,
-0.07467024028301239,
-0.19015930593013763,
-0.07659970223903656,
0.2146892100572586,
0.16677561402320862,
0.023834319785237312,
0.010956118814647198,
0.20128153264522552,
0.13420945405960083,
-0.10974107682704926,
0.038155537098646164,
0.1124759167432785,
0.32669299840927124,
-0.04074481129646301,
-0.10793953388929367,
0.05695303529500961,
0.300048828125,
0.03303273022174835,
-0.39159780740737915,
0.29139360785484314,
0.10614937543869019,
0.07935968786478043,
0.0549173466861248,
-0.01375291682779789,
0.17538508772850037,
0.038044631481170654,
0.07017099857330322,
0.252228707075119,
0.027258161455392838,
-0.024230832234025,
0.2429627925157547,
-0.09773221611976624,
0.08018375933170319,
0.29229554533958435,
-0.16984252631664276,
0.01940113492310047,
-0.045129820704460144,
-0.030799854546785355,
0.21372942626476288,
0.1869591623544693,
-0.09396952390670776,
0.016336239874362946,
-0.005128415767103434,
0.020123083144426346,
0.2592410743236542,
0.18821805715560913,
-0.09066233038902283,
0.08885867893695831,
0.011293047107756138,
0.04637425020337105,
0.3559024930000305,
-0.06260193884372711,
0.035659823566675186,
-0.12915070354938507,
0.06413429230451584,
0.06004326418042183,
-0.031130695715546608,
0.08142109960317612,
-0.013166574761271477,
0.12821730971336365,
-0.15755076706409454,
0.02978731133043766,
-0.05432027205824852,
0.11572588235139847,
-0.12354995310306549,
-0.35312625765800476,
0.0388839915394783,
0.04549120366573334,
-0.0013153200270608068,
0.10797683149576187,
0.060487452894449234,
-0.07377781718969345,
-0.023867705836892128,
-0.2878371477127075,
-0.07018643617630005,
-0.20402850210666656,
0.20107470452785492,
-0.03349010646343231,
-0.12452388554811478,
0.16418954730033875,
0.08780238032341003,
-0.18366579711437225,
-0.012009929865598679,
-0.22011372447013855,
-0.16235709190368652,
-0.37064915895462036,
0.13750053942203522,
-0.03230402618646622,
0.01691441610455513,
-0.05784830451011658,
0.12805502116680145,
0.1557805836200714,
-0.13608847558498383,
-0.024359168484807014,
-0.29827067255973816,
0.05894118919968605,
-0.21863466501235962,
0.02072202041745186,
-0.25957340002059937,
0.11485229432582855,
0.2127821296453476,
-0.11294202506542206,
0.22974394261837006,
0.06582038849592209,
0.019795706495642662,
-0.18070027232170105,
0.06272656470537186,
-0.10493190586566925,
-0.33930090069770813,
0.03203407675027847,
-0.27892404794692993,
-0.314113050699234,
-0.23595595359802246,
0.15165607631206512,
0.06798835098743439,
-0.10754606872797012,
-0.03500908240675926,
-0.13233664631843567,
-0.21916905045509338,
0.19493956863880157,
0.060813918709754944,
-0.21893256902694702,
0.16265711188316345,
-0.034920357167720795,
0.13348709046840668,
0.21683953702449799,
0.07990060746669769,
-0.14444765448570251,
0.1395282745361328,
-0.10651250183582306,
-0.2084982991218567,
0.023754455149173737,
0.14853455126285553,
0.06884845346212387,
0.39972347021102905,
-0.008032022975385189,
0.1364673674106598,
0.03782876953482628,
-0.15575405955314636,
0.10954379290342331,
-0.11806964874267578,
0.4166520833969116,
-0.3572293519973755,
-0.20377841591835022,
0.07919146865606308,
-0.06045179441571236,
-0.11521590501070023,
0.013692613691091537,
-0.010317306965589523,
0.03824546933174133,
0.2588641047477722,
-0.09769194573163986,
0.08556865155696869,
-0.13696004450321198,
0.24305163323879242,
-0.10871689021587372,
-0.2574074864387512,
-0.010221490636467934,
-0.1409853845834732,
-0.07108903676271439,
-0.0774274691939354,
0.10676858574151993,
0.06357161700725555,
-0.1418798416852951,
-0.21520087122917175,
0.08061621338129044,
-0.07802574336528778,
-0.04195307567715645,
-0.1970110982656479,
-0.0482737198472023,
0.1295234113931656,
-0.08416703343391418,
0.17826950550079346,
-0.1498197466135025,
0.04720649495720863,
0.10966695100069046,
-0.07828415930271149,
0.1177976205945015,
-0.12079992890357971,
-0.04100289195775986,
0.0901811495423317,
-0.020192885771393776,
0.16929946839809418,
-0.14878959953784943,
0.1859772652387619,
0.02922283299267292,
0.23150135576725006,
0.07700605690479279,
-0.14893658459186554,
0.1976138949394226,
-0.22436314821243286,
-0.04864265024662018,
-0.08206887543201447,
0.09089158475399017,
0.14143022894859314,
-0.04675701633095741,
0.13808268308639526,
0.060064904391765594,
-0.24304011464118958,
0.031964708119630814,
0.01647297665476799,
-0.12362045049667358,
-0.007644788362085819,
-0.054254017770290375,
0.057265426963567734,
-0.16202767193317413,
-0.10784483700990677,
-0.20213757455348969,
-0.06977671384811401,
0.0806765928864479,
-0.275064080953598,
0.2389085292816162,
-0.06568308174610138,
0.05752921849489212,
0.02756878361105919,
0.07490561157464981,
0.04836185649037361,
0.04550401121377945,
0.005182262510061264,
0.14562609791755676,
0.14604823291301727,
-0.27460935711860657,
0.27886441349983215,
-0.06360199302434921,
-0.02479943260550499,
0.43231001496315,
0.16976642608642578,
0.13556891679763794,
0.08418906480073929,
0.13433809578418732,
-0.02029133401811123,
-0.18073703348636627,
0.0830979198217392,
-0.042322997003793716,
-0.08907374739646912,
-0.07321596890687943,
0.0489765889942646,
0.10540712624788284,
0.0310517605394125,
-0.4340973198413849,
-0.13633958995342255,
0.12761151790618896,
-0.020979447290301323,
-0.12063160538673401,
-0.14115141332149506,
-0.19715328514575958,
0.13144157826900482,
-0.11344396322965622,
-0.02831564098596573,
0.1398475468158722,
0.07929959893226624,
-0.12542352080345154,
0.03459610790014267,
-0.057496506720781326,
-0.054080624133348465,
0.06630531698465347,
-0.07689277827739716,
-0.02075769565999508,
-0.23136569559574127,
0.13666555285453796,
0.03288666531443596,
-0.11780484020709991,
-0.09045098721981049,
-0.1777600795030594,
0.19623519480228424,
-0.10528657585382462,
0.2618250548839569,
-0.22953088581562042,
0.07329791784286499,
0.08773127943277359,
-0.1882164478302002,
0.204208642244339,
0.07092209160327911,
0.3089151680469513,
-0.0134839853271842,
0.09656988829374313,
-0.15763318538665771,
0.06398077309131622,
0.07805003970861435,
0.09486496448516846,
-0.05256514623761177,
0.0963478535413742,
0.09897951781749725,
-0.0859338790178299,
-0.07716867327690125,
-0.19810597598552704,
0.03872062265872955,
-0.09922245144844055,
0.1876087784767151,
0.09148953855037689,
-0.01569904386997223,
0.4040491580963135,
-0.02433939091861248,
0.18966947495937347,
0.09442119300365448,
-0.07595974206924438,
-0.09097440540790558,
0.13295350968837738,
0.1897188425064087,
-0.07274497300386429,
-0.017380904406309128,
-0.004648133646696806,
0.0727979838848114,
0.09363728016614914,
0.19864590466022491,
-0.21824227273464203,
-0.18652674555778503,
-0.0740061104297638,
-0.09263140708208084,
-0.06980308890342712,
-0.11418970674276352,
0.16463114321231842,
0.3185534179210663,
-0.2174927443265915,
0.07208264619112015,
-0.12697488069534302,
-0.05896332114934921,
0.254025936126709,
-0.19524385035037994,
0.08248522132635117,
0.4768393039703369,
0.18142497539520264,
0.10103217512369156,
-0.00038119335658848286,
0.3805072605609894,
-0.07706695795059204,
-0.03300923854112625,
-0.11177288740873337,
0.14365270733833313,
0.02246284671127796,
-0.17061761021614075,
0.0935586616396904,
0.25261741876602173,
0.24412420392036438,
-0.24212461709976196,
-0.03741135075688362,
-0.1645679622888565,
0.09710279107093811,
-0.04328141734004021,
-0.08968926966190338,
0.15847617387771606,
0.0917619988322258,
-0.21789398789405823,
-0.07191182672977448,
0.2006160467863083,
0.04590088129043579,
0.15509161353111267,
-0.35194236040115356,
0.11010298132896423,
-0.06229571998119354,
0.2246037870645523,
-0.006669540423899889,
0.37723755836486816,
-0.037730153650045395,
0.0003984812065027654,
-0.13168548047542572,
-0.13211064040660858,
0.21630515158176422,
-0.17123137414455414,
-0.13633805513381958,
0.056977760046720505,
-0.010595878586173058,
0.013205274939537048,
0.022121870890259743,
0.13660986721515656,
0.003539102850481868,
0.07093410938978195,
0.11544439941644669,
0.10726729035377502,
0.08943575620651245,
-0.05008268728852272,
-0.1400628536939621,
-0.06512624770402908,
0.14621831476688385,
0.20349645614624023,
0.02863849326968193,
0.008678458631038666,
0.09418490529060364,
-0.1426287442445755,
-0.25179651379585266,
-0.31442224979400635,
-0.0920637771487236,
-0.0747656598687172,
0.11841526627540588,
-0.037265826016664505,
-0.052643898874521255,
0.15887820720672607,
-0.015370802953839302,
0.2278432697057724,
-0.22147826850414276,
0.05037783086299896,
0.05053701624274254,
-0.12857472896575928,
0.009601949714124203,
-0.02305429056286812,
0.02888215146958828,
0.16745291650295258,
0.0790136381983757,
-0.04810131713747978,
0.09936850517988205,
-0.12752264738082886,
-0.4039556086063385,
-0.18434688448905945,
0.10588308423757553,
0.22301918268203735,
-0.15252114832401276,
0.01396735105663538,
0.12050924450159073,
0.1588592678308487,
-0.22828981280326843,
0.06458113342523575,
0.5105617642402649,
-0.0742969885468483,
-0.362897127866745,
-0.03302842006087303,
-0.24711747467517853,
0.15226934850215912,
0.059472132474184036,
-0.09752215445041656,
-0.05947454646229744,
-0.06280691176652908,
0.03364817053079605,
-0.015160457231104374,
-0.013006326742470264,
-0.10753072798252106,
-0.012823540717363358,
-0.21420936286449432,
-0.2039896696805954,
0.25372427701950073,
0.06468255072832108,
-0.04871427267789841,
-0.053538545966148376,
0.0826941654086113,
0.17277458310127258,
0.14247804880142212,
-0.07942723482847214,
0.11872611939907074,
-0.09801090508699417,
0.1621217280626297,
-0.27219972014427185,
-0.1011226624250412,
-0.172612726688385,
0.10981559008359909,
-0.024721834808588028,
0.1617451161146164,
0.28426703810691833,
-0.014073677361011505,
-0.05369282141327858,
-0.26408645510673523,
0.01992783509194851,
-0.26312822103500366,
-0.15193575620651245,
0.13169434666633606,
0.19340236485004425,
-0.028917880728840828,
-0.1172480434179306,
0.3527681231498718,
-0.16382941603660583,
-0.0038567897863686085,
0.1596893072128296,
0.1714477688074112,
-0.02249608375132084,
-0.08990047127008438,
-0.14469894766807556,
-0.13470251858234406,
-0.15135452151298523,
0.00963005144149065,
-0.15308481454849243,
0.13861629366874695,
-0.050591833889484406,
-0.14650265872478485,
-0.025118757039308548,
-0.034092217683792114,
0.09761177748441696,
0.02965562976896763,
0.047634970396757126,
0.22604426741600037,
-0.07119748741388321,
0.11838875710964203,
0.0034081130288541317,
0.19532151520252228,
0.0352436900138855,
-0.1599116027355194,
-0.005531339906156063,
0.06158355623483658,
0.26855960488319397,
-0.18654799461364746,
-0.08751146495342255,
-0.3061569333076477,
-0.056565139442682266,
-0.17325732111930847,
0.19270329177379608,
-0.15165269374847412,
-0.3470177948474884,
0.1396704912185669,
0.17260831594467163,
-0.028148479759693146,
0.36186927556991577,
0.25196409225463867,
0.1764674335718155
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. time. The rapid and severe nature of the overgrowth poses a challenge to orthopedic management. It is not uncommon for the overgrowth to accelerate rapidly in childhood, with leg length discrepancies of 20 cm being reported. Scoliotic curves of more than 90° are not uncommon. Any bone can be affected.Many individuals with PS have (often unilateral) overgrowth of the tonsils/adenoids. Splenic overgrowth and asymmetric enlargement of the kidneys and testes are also not uncommon in individuals with PS.Dermatologic findings. Cerebriform connective tissue nevi (CCTN) are present in most individuals with PS, and are nearly pathognomonic. CCTNs are rarely present in infancy, typically developing in childhood and progressing through adolescence. They are most commonly found on the sole, hand, alae, ear, and lacrimal puncta. True CCTNs are firm and have a distinct pattern resembling the brain's sulci and gyri (hence the term "cerebriform"). They | [
-0.044627845287323,
-0.20879875123500824,
0.05456918105483055,
-0.17028774321079254,
-0.04822339117527008,
-0.09563031047582626,
-0.08814923465251923,
0.017483077943325043,
0.01484813541173935,
0.16198274493217468,
0.23590506613254547,
0.13564887642860413,
0.0010753629030659795,
-0.01510467380285263,
-0.2934916615486145,
0.04579178988933563,
-0.06932318955659866,
-0.09325481206178665,
-0.12644964456558228,
0.11407861113548279,
-0.16066306829452515,
-0.10401029884815216,
-0.0666826069355011,
0.0039079156704247,
-0.0496501624584198,
-0.17327643930912018,
0.2848929464817047,
0.33905449509620667,
-0.024106504395604134,
0.031589556485414505,
0.013137491419911385,
-0.20245853066444397,
-0.24827927350997925,
-0.28630393743515015,
0.236475870013237,
-0.22758270800113678,
-0.18571658432483673,
-0.003456351812928915,
0.01415290031582117,
-0.0673929825425148,
-0.01607249304652214,
0.0498470738530159,
-0.17592772841453552,
-0.09308494627475739,
0.4093552529811859,
-0.05989478901028633,
-0.2780340909957886,
0.1522974818944931,
0.06081310287117958,
-0.05311834067106247,
0.2733665108680725,
0.07708360999822617,
0.24779793620109558,
-0.024337444454431534,
-0.0482112392783165,
-0.3688654899597168,
-0.05096803605556488,
-0.12778422236442566,
-0.5608846545219421,
0.14460055530071259,
0.3517879843711853,
-0.1222103089094162,
0.20648592710494995,
-0.3130248785018921,
-0.15227541327476501,
-0.23921369016170502,
0.0457613542675972,
0.16346536576747894,
0.1852674037218094,
-0.035512641072273254,
0.45335853099823,
-0.11500155925750732,
-0.2197301834821701,
-0.009101934731006622,
-0.1498652845621109,
-0.20054824650287628,
0.23499982059001923,
-0.07980404794216156,
-0.055962081998586655,
-0.18540523946285248,
0.06742455065250397,
-0.11109594255685806,
-0.17471812665462494,
0.11805486679077148,
-0.4290676712989807,
-0.14423063397407532,
-0.07053989171981812,
-0.20254062116146088,
0.028304047882556915,
0.2659722864627838,
0.16943173110485077,
-0.29595866799354553,
-0.003396576037630439,
0.08620738983154297,
0.05138764530420303,
0.14347754418849945,
0.242218479514122,
-0.08035387843847275,
-0.06644563376903534,
-0.09359534084796906,
-0.08846055716276169,
0.4444587230682373,
-0.08902536332607269,
-0.21183067560195923,
-0.05089375749230385,
-0.2998718023300171,
-0.21560047566890717,
0.12046882510185242,
-0.007244549226015806,
0.05934837460517883,
0.0013484423980116844,
-0.11645549535751343,
-0.1267826110124588,
-0.1776037961244583,
-0.3119375705718994,
-0.10718399286270142,
0.04197712242603302,
-0.3160695731639862,
-0.17762283980846405,
-0.3461637794971466,
-0.02449806034564972,
-0.2275732457637787,
0.1776917278766632,
0.020519763231277466,
0.18922486901283264,
-0.02095853164792061,
0.2549082636833191,
-0.3342357277870178,
-0.07192686200141907,
-0.15735384821891785,
-0.016667403280735016,
-0.12539567053318024,
0.001843315432779491,
-0.40504151582717896,
0.14064250886440277,
0.25297680497169495,
-0.2349507361650467,
-0.2312174290418625,
0.23671117424964905,
0.041800953447818756,
0.1699705868959427,
0.16106049716472626,
0.4011320173740387,
0.04120119288563728,
0.23410071432590485,
0.03879468888044357,
0.3161706328392029,
0.00492864940315485,
0.09844433516263962,
-0.03342496603727341,
0.4097934663295746,
-0.23161953687667847,
0.17774023115634918,
0.07548229396343231,
-0.1474936306476593,
0.03611162677407265,
-0.07097084075212479,
0.021600985899567604,
-0.0911063626408577,
0.04678308591246605,
-0.010925166308879852,
-0.11027268320322037,
-0.025481199845671654,
-0.41982781887054443,
0.0002704087528400123,
0.14498814940452576,
0.09248100221157074,
-0.4082610309123993,
0.26617562770843506,
0.11444742232561111,
-0.1726273149251938,
0.024736549705266953,
-0.2129223644733429,
0.12402716279029846,
0.06042037531733513,
-0.06806071847677231,
0.23347632586956024,
0.11774668842554092,
-0.17278842628002167,
0.16104035079479218,
0.06920398026704788,
0.14430510997772217,
-0.13235056400299072,
-0.23797661066055298,
-0.11546885222196579,
-0.31966859102249146,
-0.13683728873729706,
0.28353631496429443,
-0.2732984721660614,
0.01570681482553482,
0.1333235651254654,
-0.019982364028692245,
-0.09015870094299316,
-0.09396234899759293,
-0.09532617032527924,
-0.4845379889011383,
0.06268531829118729,
-0.26616135239601135,
0.2674841582775116,
0.02464372292160988,
0.3026592433452606,
-0.010116815567016602,
0.3525973856449127,
0.09756217896938324,
0.10347296297550201,
0.13367967307567596,
0.21728606522083282,
-0.26441675424575806,
0.09421561658382416,
0.16351772844791412,
-0.06499373912811279,
0.19197364151477814,
0.07879409193992615,
-0.014590154401957989,
0.050362955778837204,
-0.09520715475082397,
-0.15632401406764984,
-0.17668017745018005,
-0.22215786576271057,
0.18756555020809174,
-0.20480714738368988,
0.1244526132941246,
-0.05058823525905609,
-0.16822326183319092,
-0.3906288146972656,
0.08661704510450363,
-0.03126126527786255,
-0.03302507847547531,
-0.17711162567138672,
-0.03676155209541321,
-0.15018531680107117,
0.00017069437308236957,
-0.16612794995307922,
0.13264574110507965,
0.22107183933258057,
-0.38702139258384705,
-0.18941240012645721,
0.29080694913864136,
-0.022444380447268486,
0.07839831709861755,
-0.1163693219423294,
-0.06134551763534546,
-0.06603360921144485,
-0.224339097738266,
-0.3819877803325653,
0.2754293382167816,
0.014477774500846863,
0.1779204159975052,
-0.0009636945324018598,
-0.07435446977615356,
0.14823420345783234,
-0.0815773606300354,
0.24113355576992035,
0.1826660931110382,
-0.26643142104148865,
-0.17145508527755737,
0.045066311955451965,
-0.024178989231586456,
0.09289047122001648,
0.10965125262737274,
0.13323530554771423,
0.3113173544406891,
0.4167838394641876,
0.03539320454001427,
-0.37628433108329773,
-0.5220096707344055,
0.08245029300451279,
0.2187904566526413,
-0.21396589279174805,
-0.0843115746974945,
-0.10697170346975327,
0.39683881402015686,
0.013803292997181416,
0.06782883405685425,
0.05029910430312157,
0.12548553943634033,
0.13897289335727692,
-0.04546787589788437,
0.04737352579832077,
0.07733263075351715,
0.22761529684066772,
-0.13855430483818054,
-0.12817449867725372,
0.12730714678764343,
0.20795904099941254,
0.1268671602010727,
-0.4272863566875458,
0.3110804557800293,
0.1240435466170311,
-0.043221615254879,
0.10311836749315262,
0.05625632405281067,
0.16611160337924957,
-0.05229106545448303,
0.10307467728853226,
0.19478408992290497,
-0.02680882439017296,
0.03848002851009369,
0.27447131276130676,
-0.07897727936506271,
0.02095261961221695,
0.23400892317295074,
0.022332755848765373,
-0.048764076083898544,
0.10364126414060593,
-0.09351955354213715,
0.3427550196647644,
0.019002284854650497,
0.018022950738668442,
0.034067727625370026,
-0.0397401787340641,
0.17054368555545807,
0.31863802671432495,
0.06329561024904251,
0.008213475346565247,
0.003377265762537718,
0.040298134088516235,
-0.047579698264598846,
0.4752586781978607,
-0.000007202916094684042,
-0.15666650235652924,
-0.06106480583548546,
0.16571183502674103,
0.10537490993738174,
-0.051072198897600174,
-0.021978948265314102,
-0.10965581983327866,
0.13254345953464508,
-0.12909170985221863,
0.16294457018375397,
-0.15642672777175903,
0.02079003117978573,
-0.13227804005146027,
-0.43787267804145813,
0.007286041509360075,
-0.1405961960554123,
0.04109034314751625,
-0.03273146599531174,
0.06760015338659286,
-0.1608406901359558,
-0.09497160464525223,
-0.25020819902420044,
0.06380361318588257,
-0.07803642004728317,
0.026783837005496025,
0.02725992538034916,
-0.07751356810331345,
0.06019924208521843,
0.06800314038991928,
-0.15622900426387787,
-0.014042346738278866,
-0.13062824308872223,
-0.19520317018032074,
-0.3434904217720032,
0.10362400859594345,
-0.16656342148780823,
-0.02693832851946354,
-0.10226250439882278,
0.17776146531105042,
0.24379412829875946,
-0.2676956355571747,
-0.06270458549261093,
-0.26762855052948,
0.13562588393688202,
-0.12499592453241348,
0.0681728720664978,
-0.4845113158226013,
0.13629823923110962,
0.3360716700553894,
-0.10233297199010849,
0.29193082451820374,
0.17592564225196838,
0.09700015932321548,
-0.20988547801971436,
0.06512671709060669,
-0.1414281576871872,
-0.5499141216278076,
0.021938344463706017,
-0.22162505984306335,
-0.2588962912559509,
-0.30126455426216125,
0.2550688683986664,
0.2076239138841629,
-0.12554168701171875,
-0.052215997129678726,
-0.1106719896197319,
-0.2851064205169678,
0.18227772414684296,
-0.018487000837922096,
-0.13281987607479095,
0.2575908601284027,
-0.13657477498054504,
0.12239056825637817,
0.26408037543296814,
0.06849519163370132,
-0.2122235894203186,
0.21364237368106842,
-0.0542936697602272,
-0.20309504866600037,
-0.07861434668302536,
0.036550428718328476,
0.03732448071241379,
0.35309523344039917,
-0.06242077425122261,
0.11730492115020752,
-0.01072484627366066,
-0.2286902517080307,
0.15667374432086945,
-0.10452581197023392,
0.2897757887840271,
-0.2101426124572754,
-0.28630563616752625,
0.02951763942837715,
-0.15244576334953308,
-0.12638217210769653,
-0.03614804148674011,
0.12016443908214569,
0.011189731769263744,
0.22083497047424316,
-0.13293024897575378,
0.07799991220235825,
-0.09947170317173004,
0.15720105171203613,
-0.1779598891735077,
-0.10486132651567459,
-0.07452414929866791,
-0.1270224004983902,
-0.09707416594028473,
-0.13038013875484467,
0.013282367959618568,
0.028337599709630013,
-0.10457993298768997,
-0.13934247195720673,
0.17153462767601013,
-0.018773440271615982,
0.08519383519887924,
-0.1455346792936325,
-0.0777725949883461,
0.29167255759239197,
-0.06805725395679474,
0.316767156124115,
-0.14812111854553223,
0.03250972926616669,
-0.027612444013357162,
0.06209467723965645,
0.10593955218791962,
-0.14386409521102905,
-0.06799580901861191,
-0.05608746036887169,
-0.14905832707881927,
0.16503912210464478,
-0.08757688105106354,
0.1556020826101303,
0.14567726850509644,
0.1323070079088211,
-0.05352136492729187,
-0.05446680262684822,
0.16263478994369507,
-0.21342207491397858,
0.19317860901355743,
-0.22765345871448517,
0.16145865619182587,
0.10714665055274963,
-0.102266326546669,
0.11802645772695541,
0.08897960186004639,
-0.2977299094200134,
0.016284270212054253,
0.043839968740940094,
-0.12213627994060516,
-0.0313037671148777,
0.0189223550260067,
0.2067478597164154,
-0.15016800165176392,
-0.14743991196155548,
-0.2573528289794922,
-0.007890302687883377,
0.09053687006235123,
-0.11817493289709091,
0.06526851654052734,
-0.02449427917599678,
0.1734735369682312,
0.2179630994796753,
0.15259739756584167,
0.053136225789785385,
0.06904574483633041,
0.030202800408005714,
0.033286433666944504,
0.23052945733070374,
-0.47272348403930664,
0.27589815855026245,
-0.15273676812648773,
-0.03114922158420086,
0.463186115026474,
0.08433572202920914,
0.06268748641014099,
0.06507129222154617,
0.28030356764793396,
-0.05053788051009178,
-0.22891415655612946,
0.05847680941224098,
0.12513065338134766,
-0.04672684893012047,
-0.06519689410924911,
-0.025261519476771355,
0.07073619216680527,
0.05828849598765373,
-0.39436599612236023,
-0.35078534483909607,
0.042008645832538605,
-0.020182235166430473,
-0.08757222443819046,
-0.08537749946117401,
-0.20350362360477448,
0.26959627866744995,
-0.018961502239108086,
-0.035780515521764755,
0.09471424669027328,
0.12720640003681183,
-0.12428667396306992,
-0.007121061906218529,
0.11303534358739853,
-0.09960895776748657,
-0.020931730046868324,
0.03715179115533829,
-0.03433917835354805,
-0.1469579041004181,
0.06099667400121689,
-0.0023955004289746284,
-0.03146091848611832,
-0.2786318361759186,
-0.16566550731658936,
0.20993930101394653,
0.10104091465473175,
0.2136516273021698,
-0.3526257276535034,
-0.041482970118522644,
-0.061896875500679016,
0.082169309258461,
0.20894120633602142,
0.016240116208791733,
0.29839494824409485,
0.04082034155726433,
0.04770443215966225,
0.06786505877971649,
-0.00021690840367227793,
0.09957564622163773,
0.13551701605319977,
-0.02643127180635929,
0.10351524502038956,
0.11338695138692856,
-0.18441946804523468,
-0.06911548972129822,
-0.10715612769126892,
-0.18642178177833557,
-0.1807849109172821,
0.048337262123823166,
0.018949389457702637,
-0.10832894593477249,
0.495911180973053,
0.03822578862309456,
0.18549858033657074,
0.05530957505106926,
0.05045243725180626,
-0.09111454337835312,
0.11833981424570084,
0.26685017347335815,
-0.007846333086490631,
-0.13237302005290985,
0.0576704740524292,
0.13445945084095,
-0.019994350150227547,
0.09204888343811035,
-0.3804287016391754,
-0.16343118250370026,
-0.018319176509976387,
-0.19565673172473907,
-0.10174734145402908,
-0.19002801179885864,
0.011938145384192467,
0.38017958402633667,
-0.07515892386436462,
0.04961758852005005,
-0.16355103254318237,
-0.016109727323055267,
0.4457893967628479,
-0.41346535086631775,
0.14051178097724915,
0.34256455302238464,
0.1880929172039032,
0.10027224570512772,
-0.22171956300735474,
0.3262195587158203,
-0.07709186524152756,
0.10135723650455475,
-0.05013657733798027,
0.1929958313703537,
0.1933440864086151,
-0.09135957807302475,
0.04544591158628464,
0.10405723750591278,
0.2055290937423706,
-0.168376624584198,
-0.05308226868510246,
-0.06386853009462357,
0.06906998157501221,
-0.011331387795507908,
0.002658864250406623,
0.042454302310943604,
-0.026464352384209633,
-0.1569809466600418,
0.0017943584825843573,
0.12366844713687897,
0.017603885382413864,
0.31549596786499023,
-0.38011109828948975,
0.0790296345949173,
-0.024216463789343834,
0.23078009486198425,
0.0708017647266388,
0.4124409258365631,
-0.0709523856639862,
0.18728165328502655,
-0.10475602000951767,
-0.061152443289756775,
0.33861619234085083,
-0.046192288398742676,
-0.11809851229190826,
-0.07283788174390793,
0.032606080174446106,
0.04117237776517868,
-0.05236119404435158,
-0.022286223247647285,
0.010263747535645962,
0.10440783202648163,
0.21185225248336792,
0.009879982098937035,
-0.03899727761745453,
0.0924612507224083,
-0.17328859865665436,
-0.02085014432668686,
0.10847748816013336,
0.24423985183238983,
0.17918187379837036,
-0.022335849702358246,
0.13374528288841248,
-0.2149742841720581,
-0.2457646280527115,
-0.2749558091163635,
-0.23969171941280365,
-0.07822339981794357,
0.10233486443758011,
-0.02338484115898609,
-0.10110649466514587,
0.166941300034523,
0.05745615437626839,
0.2002190202474594,
-0.1037067249417305,
0.015692537650465965,
0.10540635883808136,
-0.12820063531398773,
-0.10066569596529007,
-0.09332479536533356,
0.013710089959204197,
0.19193100929260254,
0.002255900762975216,
-0.19346106052398682,
0.054374147206544876,
-0.26511842012405396,
-0.3856549859046936,
-0.27609914541244507,
0.1142096221446991,
0.15584051609039307,
-0.09532831609249115,
0.15653356909751892,
0.23510722815990448,
0.2733103930950165,
-0.3201221227645874,
0.05559517443180084,
0.5039961338043213,
0.037007808685302734,
-0.30121076107025146,
0.17404764890670776,
-0.2025531381368637,
0.28867796063423157,
0.06603123247623444,
-0.13938027620315552,
-0.06769253313541412,
-0.0036762317176908255,
0.07973466068506241,
-0.04523855820298195,
-0.016108037903904915,
-0.1954045444726944,
-0.1353575587272644,
-0.08428295701742172,
-0.2608692944049835,
0.2645430564880371,
0.038986433297395706,
0.08237851411104202,
-0.0010531141888350248,
0.11725020408630371,
0.17382624745368958,
0.10837022215127945,
0.006710084620863199,
0.23326867818832397,
-0.12367615848779678,
0.22402608394622803,
-0.21293023228645325,
-0.04083075374364853,
-0.1789712905883789,
0.23628835380077362,
-0.08231411129236221,
-0.0175588708370924,
0.20656612515449524,
-0.0640813484787941,
-0.0459759458899498,
-0.38786011934280396,
0.05586392432451248,
-0.3784504234790802,
-0.1161094605922699,
-0.032348766922950745,
0.18494772911071777,
0.05379165709018707,
-0.12503975629806519,
0.1834089756011963,
-0.19150762259960175,
0.1294514387845993,
-0.033922016620635986,
0.21699117124080658,
0.08495834469795227,
-0.0072073303163051605,
-0.16072602570056915,
-0.08157382905483246,
-0.10923063009977341,
-0.07902248948812485,
-0.1091729924082756,
0.11088965088129044,
-0.0003063219483010471,
-0.11207251250743866,
-0.07084035873413086,
0.09577669203281403,
0.05643278360366821,
-0.03530922159552574,
0.1085047498345375,
0.14283797144889832,
-0.03477346897125244,
0.04482520371675491,
0.10190660506486893,
0.0322391651570797,
0.04712347686290741,
-0.12064941972494125,
0.12269265204668045,
0.20125432312488556,
0.2768857777118683,
-0.08332010358572006,
-0.04577060043811798,
-0.3103029727935791,
-0.010117864236235619,
-0.15628504753112793,
0.05766754597425461,
-0.1485922932624817,
-0.09933669120073318,
0.01274552196264267,
0.19074933230876923,
-0.15437796711921692,
0.36403921246528625,
0.028696367517113686,
0.1724577248096466
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. .Dermatologic findings. Cerebriform connective tissue nevi (CCTN) are present in most individuals with PS, and are nearly pathognomonic. CCTNs are rarely present in infancy, typically developing in childhood and progressing through adolescence. They are most commonly found on the sole, hand, alae, ear, and lacrimal puncta. True CCTNs are firm and have a distinct pattern resembling the brain's sulci and gyri (hence the term "cerebriform"). They should not be confused with prominent plantar or palmar wrinkling seen in other forms of overgrowth (see Sapp et al for photographic examples of lesions with similar appearance to a CCTN). CCTNs rarely progress in adulthood . The sulci of CCTNs commonly get deep enough in late adolescence to pose challenges with cleanliness and malodor.Linear verrucous epidermal nevi are streaky, pigmented, rough nevi that often follow the lines of Blaschko. | [
0.0637565404176712,
-0.06731291115283966,
-0.008242824114859104,
-0.0979548767209053,
0.0953594371676445,
-0.13106532394886017,
-0.14364714920520782,
-0.06685101240873337,
-0.2167983502149582,
0.058989331126213074,
0.42317065596580505,
-0.0074686394073069096,
0.09708327054977417,
-0.16021114587783813,
-0.005510235670953989,
0.07378920167684555,
-0.16428989171981812,
-0.014145041815936565,
-0.1279081106185913,
0.01656142994761467,
-0.0377238504588604,
-0.08239433914422989,
0.011422745883464813,
0.19918234646320343,
-0.15579526126384735,
-0.035085003823041916,
0.19913174211978912,
0.3942037522792816,
0.011998116038739681,
0.014384537935256958,
-0.08590193837881088,
-0.0040073576383292675,
-0.12343883514404297,
-0.20089614391326904,
0.19974282383918762,
-0.23625390231609344,
-0.22498181462287903,
-0.08491722494363785,
-0.03518589213490486,
-0.07001535594463348,
-0.11332417279481888,
0.0973980575799942,
-0.3054508566856384,
-0.11872010678052902,
0.30910709500312805,
0.0060776458121836185,
-0.10513976216316223,
0.12737825512886047,
-0.026368729770183563,
0.18765850365161896,
0.2499753087759018,
-0.03544589504599571,
0.12226377427577972,
0.09071879833936691,
0.1003463864326477,
-0.2063450962305069,
-0.156717911362648,
-0.2929192781448364,
-0.6097385287284851,
0.09669695049524307,
0.22181206941604614,
0.15929274260997772,
0.24032197892665863,
-0.3647770583629608,
0.11801301687955856,
-0.12465395033359528,
-0.09572410583496094,
0.09255865961313248,
0.24348275363445282,
-0.03149466961622238,
0.43958553671836853,
-0.28134673833847046,
-0.21941089630126953,
-0.1291349083185196,
-0.2200208455324173,
-0.20056897401809692,
0.2042437642812729,
-0.05927510932087898,
-0.09418577700853348,
-0.28641268610954285,
0.11414780467748642,
-0.21625089645385742,
-0.0853569507598877,
0.1940867304801941,
-0.4311528503894806,
-0.20528090000152588,
0.02026323415338993,
-0.03370346501469612,
0.02362873964011669,
0.2842796742916107,
0.2162739634513855,
0.03309201821684837,
-0.16758273541927338,
0.14394298195838928,
-0.09370169043540955,
-0.0543377548456192,
0.19457855820655823,
-0.16828274726867676,
0.02886415272951126,
-0.007431193254888058,
-0.10129465162754059,
0.23702166974544525,
-0.0643853098154068,
-0.18782176077365875,
0.02249891869723797,
-0.27149516344070435,
-0.30224335193634033,
0.13990281522274017,
-0.05366525426506996,
0.0670546367764473,
-0.10499846190214157,
-0.11150900274515152,
-0.13622885942459106,
-0.09431983530521393,
-0.41254112124443054,
-0.17618714272975922,
0.16886743903160095,
-0.097781702876091,
-0.016398226842284203,
-0.1510007232427597,
-0.04855232685804367,
-0.15079262852668762,
0.15351083874702454,
-0.035409003496170044,
0.04718317091464996,
-0.06971684843301773,
0.4344575107097626,
-0.24167920649051666,
-0.17109014093875885,
-0.21845149993896484,
0.06046042963862419,
-0.19355954229831696,
-0.05687772110104561,
-0.2795032262802124,
0.19551366567611694,
0.16731709241867065,
-0.23645956814289093,
-0.0022073735017329454,
0.049599725753068924,
0.12698450684547424,
-0.016895072534680367,
0.10138405114412308,
0.3323807418346405,
0.0024863113649189472,
-0.08704549074172974,
0.13976815342903137,
0.14142946898937225,
0.13836191594600677,
0.04955112934112549,
-0.005283090751618147,
0.20654353499412537,
-0.10716837644577026,
0.28368452191352844,
0.10913342237472534,
0.10247797518968582,
0.10025928169488907,
-0.1714962273836136,
0.0064232079312205315,
-0.23230397701263428,
0.0530875138938427,
0.055233780294656754,
-0.1309196799993515,
0.056211695075035095,
-0.37723156809806824,
0.043944936245679855,
0.28567320108413696,
0.0623486302793026,
-0.26277169585227966,
0.2749537229537964,
0.18035559356212616,
-0.18261311948299408,
0.19680945575237274,
-0.2589462697505951,
0.17771564424037933,
0.02326067164540291,
-0.02117033675312996,
0.3000684380531311,
0.12005931884050369,
-0.19212354719638824,
0.2501508295536041,
0.22704070806503296,
0.025700803846120834,
-0.02073672227561474,
-0.2152082324028015,
0.07222935557365417,
-0.1656665802001953,
-0.1813783496618271,
0.2762031555175781,
-0.3001004457473755,
0.027010660618543625,
0.21947021782398224,
-0.19247570633888245,
-0.2249845713376999,
-0.17482484877109528,
-0.17520447075366974,
-0.38590171933174133,
-0.18991471827030182,
-0.07235138863325119,
0.3578266203403473,
0.06761743128299713,
0.035128384828567505,
0.0622810497879982,
0.20286515355110168,
0.05659736692905426,
0.19963042438030243,
0.15620207786560059,
0.09617026150226593,
-0.39522552490234375,
0.1712547093629837,
0.18676647543907166,
-0.017087694257497787,
0.20059211552143097,
0.18289709091186523,
-0.03255503624677658,
0.03615758568048477,
-0.02583201602101326,
-0.04171096533536911,
-0.025727996602654457,
-0.1834740936756134,
0.2717689275741577,
-0.261669397354126,
0.3173036575317383,
-0.1322125345468521,
-0.13261805474758148,
-0.2911795675754547,
0.1348324418067932,
0.06202620640397072,
0.013412599451839924,
-0.05991586297750473,
0.027589522302150726,
0.009428088553249836,
-0.040306638926267624,
-0.17217327654361725,
-0.04751703888177872,
0.2360360324382782,
-0.3200359344482422,
-0.10676155984401703,
0.21764816343784332,
-0.10191851854324341,
-0.008306043222546577,
-0.3017628490924835,
-0.09694323688745499,
-0.06433125585317612,
-0.110709547996521,
-0.3447057902812958,
0.08697109669446945,
0.12911058962345123,
0.22617660462856293,
-0.1802946925163269,
0.012589724734425545,
0.17115409672260284,
-0.16577744483947754,
0.2533411681652069,
0.16917800903320312,
-0.21538881957530975,
-0.10846856236457825,
0.02166805788874626,
-0.06952933967113495,
0.1749267429113388,
0.14775396883487701,
0.3034842908382416,
0.2264704406261444,
0.2910424470901489,
0.011472425423562527,
-0.27921169996261597,
-0.2762005031108856,
-0.11333193629980087,
0.21768079698085785,
-0.20427165925502777,
-0.26235145330429077,
-0.2510552704334259,
0.29077696800231934,
0.20021963119506836,
0.07564425468444824,
0.2105572521686554,
0.023846978321671486,
0.23385967314243317,
0.0485687181353569,
0.08133038878440857,
0.14421884715557098,
-0.00500558502972126,
-0.09533508867025375,
-0.08936606347560883,
-0.06113145500421524,
0.28990134596824646,
0.07791639864444733,
-0.4289849102497101,
0.2114396095275879,
0.07079840451478958,
-0.10028725117444992,
-0.04236426576972008,
-0.01629309169948101,
0.1377294361591339,
-0.09257994592189789,
0.17427581548690796,
0.14962756633758545,
-0.016198666766285896,
-0.10984496027231216,
0.2482377588748932,
-0.015048387460410595,
0.08675800263881683,
0.1529955416917801,
-0.019257912412285805,
0.1312372237443924,
0.20914146304130554,
-0.2411898374557495,
0.3493644893169403,
-0.1782284677028656,
0.10401389747858047,
-0.07860378175973892,
-0.04225903004407883,
0.23592382669448853,
0.24314554035663605,
-0.02169685997068882,
0.11643322557210922,
-0.004266425501555204,
0.08693235367536545,
0.055189624428749084,
0.3961407542228699,
0.024839239194989204,
-0.10596740245819092,
0.012722313404083252,
0.1100391298532486,
0.12495603412389755,
-0.03191967308521271,
0.14668965339660645,
-0.02241697534918785,
0.20323733985424042,
-0.19830812513828278,
0.15588918328285217,
-0.15111200511455536,
0.06907380372285843,
-0.05558738112449646,
-0.31741517782211304,
-0.054678816348314285,
-0.08926799148321152,
-0.05272447690367699,
-0.17956727743148804,
0.20392166078090668,
-0.055499117821455,
-0.12494466453790665,
-0.35539543628692627,
-0.02457254007458687,
-0.06319023668766022,
-0.16395194828510284,
0.11643553525209427,
0.04043088108301163,
0.061238884925842285,
-0.05956985801458359,
0.11977212131023407,
0.017021020874381065,
-0.05663375183939934,
-0.14244294166564941,
-0.2620307505130768,
0.01303847786039114,
-0.04034948721528053,
0.026678962633013725,
-0.11628395318984985,
0.025467058643698692,
0.15010616183280945,
-0.14359445869922638,
-0.002568267285823822,
-0.3590450882911682,
0.06103741377592087,
-0.12296470254659653,
-0.03773992136120796,
-0.4449462294578552,
0.15190117061138153,
0.30761587619781494,
-0.15939725935459137,
0.3568808436393738,
-0.014422846958041191,
0.19886362552642822,
-0.14421476423740387,
0.10815756767988205,
-0.026279564946889877,
-0.25604504346847534,
-0.19753359258174896,
-0.16372649371623993,
-0.10192519426345825,
-0.2124386429786682,
0.397029310464859,
0.1908147782087326,
0.03168649226427078,
-0.17139525711536407,
0.11132302135229111,
-0.34115663170814514,
-0.08491025120019913,
-0.10066144168376923,
-0.15091101825237274,
0.24998290836811066,
-0.11513615399599075,
-0.0009837449761107564,
0.2475854754447937,
0.04372071102261543,
-0.05001111328601837,
-0.06894606351852417,
-0.03628162294626236,
-0.23095297813415527,
-0.06747055798768997,
-0.1940576285123825,
0.09505198895931244,
0.31375351548194885,
0.08719900995492935,
0.17820648849010468,
0.02179855667054653,
-0.13224764168262482,
-0.05530044436454773,
-0.191682830452919,
0.2725992798805237,
-0.16230571269989014,
-0.24842992424964905,
-0.1528569608926773,
-0.06397610157728195,
-0.18093471229076385,
-0.0453929677605629,
0.2907468378543854,
0.06714333593845367,
0.09693087637424469,
-0.2065398395061493,
0.09995716065168381,
-0.26233139634132385,
-0.017356498166918755,
-0.15032297372817993,
-0.11593185365200043,
-0.05729292705655098,
-0.033663731068372726,
0.11369667202234268,
0.008755551651120186,
0.00427077803760767,
0.15911391377449036,
-0.0736679807305336,
-0.11127698421478271,
0.24620269238948822,
0.05697343870997429,
0.17335079610347748,
0.13649073243141174,
0.04193004220724106,
0.0703093484044075,
0.01527902390807867,
0.39726904034614563,
0.1405610889196396,
0.05573299899697304,
0.05794980004429817,
0.1465613692998886,
0.005469306372106075,
-0.031778544187545776,
0.091384157538414,
-0.09684143960475922,
-0.18396785855293274,
-0.002764296717941761,
0.08278542757034302,
0.12108977138996124,
0.06961424648761749,
0.24864915013313293,
0.11773692816495895,
-0.03463124856352806,
-0.032862864434719086,
-0.21555987000465393,
0.024790367111563683,
0.11987550556659698,
0.10030703246593475,
0.05020700767636299,
-0.05511074885725975,
0.03658374026417732,
0.15950724482536316,
-0.42675909399986267,
-0.05440056324005127,
0.041553910821676254,
-0.15856122970581055,
-0.03256947547197342,
0.12051667273044586,
0.21753372251987457,
-0.0741400495171547,
-0.03454622998833656,
-0.028495078906416893,
0.012075738050043583,
-0.032947294414043427,
0.1758546680212021,
-0.08416563272476196,
0.19438742101192474,
0.2020729035139084,
0.21780163049697876,
-0.014842829667031765,
-0.06192059442400932,
0.1723703294992447,
0.08717934787273407,
-0.02154722809791565,
0.32381144165992737,
-0.26154953241348267,
-0.010010764002799988,
-0.2162473350763321,
0.03244573250412941,
0.5215526819229126,
0.0061041563749313354,
0.006058214232325554,
-0.10330623388290405,
0.02707674354314804,
-0.12716084718704224,
-0.3467588424682617,
0.13093212246894836,
0.1406949907541275,
0.11773291975259781,
0.02237943932414055,
-0.005846365820616484,
-0.03120964765548706,
-0.04566464200615883,
-0.4452279806137085,
-0.2400209903717041,
-0.02633979730308056,
-0.19677790999412537,
-0.03788476809859276,
-0.07489841431379318,
-0.3542318344116211,
0.14283792674541473,
-0.06450238078832626,
-0.09256616979837418,
0.11284969747066498,
0.05518068000674248,
-0.0958777442574501,
-0.18027038872241974,
0.022291330620646477,
0.0346384197473526,
-0.09172523021697998,
0.07409370690584183,
-0.025217175483703613,
0.09576413780450821,
0.1302809715270996,
-0.03375448286533356,
0.043405719101428986,
-0.24867945909500122,
-0.07311774045228958,
0.08495275676250458,
0.1171778067946434,
0.060294926166534424,
-0.2577301859855652,
0.026423882693052292,
-0.10687615722417831,
0.14095385372638702,
0.13738903403282166,
-0.10093605518341064,
0.26267528533935547,
0.1439378708600998,
0.24067004024982452,
0.10484147816896439,
-0.07594458013772964,
0.008022195659577847,
0.15508443117141724,
0.08551827073097229,
0.11676234006881714,
-0.0876554399728775,
-0.22872929275035858,
-0.05673237517476082,
0.07441270351409912,
-0.22391709685325623,
-0.09043580293655396,
0.07189051061868668,
0.0818730816245079,
-0.13585792481899261,
0.40279048681259155,
-0.07374975085258484,
0.14123325049877167,
-0.08863183856010437,
0.04045713692903519,
0.04733911529183388,
0.22808484733104706,
0.3308783769607544,
-0.01935645565390587,
-0.0324399508535862,
0.13257256150245667,
0.08073858171701431,
-0.09271856397390366,
0.27277910709381104,
-0.1454755961894989,
-0.12042282521724701,
0.03336715325713158,
-0.20924462378025055,
-0.07779832184314728,
-0.23638483881950378,
0.05883089080452919,
0.2726118266582489,
-0.13224193453788757,
-0.08079429715871811,
-0.11004026234149933,
0.07742887735366821,
0.47714823484420776,
-0.1268283724784851,
0.1992260366678238,
0.3063108026981354,
0.10494862496852875,
0.15365250408649445,
-0.18238423764705658,
0.17458264529705048,
0.05121534317731857,
0.1477137804031372,
0.06832436472177505,
0.2049625813961029,
-0.08636695146560669,
0.10914202779531479,
0.09087985008955002,
0.12353963404893875,
0.09174466133117676,
-0.11135731637477875,
-0.21548542380332947,
0.07548534125089645,
0.16316762566566467,
0.19044050574302673,
-0.21436208486557007,
-0.0071194833144545555,
-0.04825635254383087,
-0.07335080951452255,
-0.18205511569976807,
0.09711578488349915,
0.017760777845978737,
0.35116198658943176,
-0.34451189637184143,
0.15082332491874695,
0.08541422337293625,
0.13707587122917175,
0.0641600489616394,
0.35414355993270874,
-0.22213244438171387,
0.14319780468940735,
-0.08030753582715988,
-0.005121762864291668,
0.1981634795665741,
-0.06814055144786835,
-0.1678023785352707,
0.11089140921831131,
0.16566163301467896,
-0.06418746709823608,
-0.2262822389602661,
-0.014486257918179035,
0.1713135540485382,
0.2100898176431656,
0.08698105067014694,
-0.024222757667303085,
0.011182204820215702,
0.09925233572721481,
-0.040383171290159225,
0.01321884524077177,
0.11442577838897705,
-0.039620835334062576,
0.298357218503952,
-0.13057100772857666,
0.26388728618621826,
-0.03080500103533268,
-0.21761015057563782,
-0.1508558988571167,
-0.24648769199848175,
-0.05151787027716637,
0.055516649037599564,
-0.2629111707210541,
-0.0336628332734108,
0.14307501912117004,
0.08966704457998276,
0.19468465447425842,
0.01573151722550392,
0.029416387900710106,
0.08823813498020172,
-0.06395517289638519,
-0.07387551665306091,
-0.16463042795658112,
-0.053373873233795166,
0.1391492635011673,
0.24606673419475555,
-0.15651564300060272,
0.08078787475824356,
-0.24199682474136353,
-0.20258499681949615,
-0.2509694993495941,
0.06554460525512695,
-0.024555526673793793,
-0.06521345674991608,
0.2075948864221573,
0.003529592417180538,
0.25294581055641174,
-0.3567962348461151,
0.13441863656044006,
0.3496858477592468,
0.0510113388299942,
-0.19148923456668854,
-0.08959605544805527,
-0.3267456889152527,
0.3374483585357666,
0.09523329883813858,
-0.08737406134605408,
0.03911002725362778,
0.1271326094865799,
0.01948707550764084,
0.06264560669660568,
0.15299005806446075,
-0.11597612500190735,
0.08190691471099854,
-0.13085415959358215,
-0.27184799313545227,
0.45427581667900085,
0.10181375592947006,
-0.001905149663798511,
0.09584715962409973,
-0.055816978216171265,
0.22309906780719757,
0.02039968967437744,
0.09033516049385071,
0.30106833577156067,
-0.18078851699829102,
0.13443773984909058,
-0.14522072672843933,
0.003594609908759594,
-0.05958693474531174,
0.1207098737359047,
-0.08389877527952194,
-0.277648001909256,
0.10749798268079758,
-0.04013097658753395,
0.16077327728271484,
-0.2699600160121918,
-0.1281760185956955,
-0.2238665223121643,
-0.1117447018623352,
-0.14733582735061646,
-0.05722609907388687,
0.18239820003509521,
0.002375236479565501,
0.0388178750872612,
0.025406725704669952,
0.2067764550447464,
-0.3496761918067932,
0.22746865451335907,
0.00288388691842556,
0.1623937487602234,
-0.19786687195301056,
-0.12423015385866165,
-0.06995264440774918,
-0.24620862305164337,
-0.06570228189229965,
0.03163997456431389,
-0.1465601921081543,
-0.3906762897968292,
-0.22826072573661804,
0.11578093469142914,
-0.11048901081085205,
-0.13859140872955322,
0.14274337887763977,
-0.02772803045809269,
-0.06525672227144241,
0.0485985241830349,
0.0894131138920784,
-0.05298646539449692,
-0.038662463426589966,
0.10720851272344589,
0.08722632378339767,
0.26386263966560364,
0.2532464861869812,
-0.11183249950408936,
-0.05984479561448097,
-0.4203408658504486,
-0.0017971204360947013,
-0.02816805988550186,
0.09237794578075409,
-0.21794047951698303,
-0.1568399965763092,
0.030622446909546852,
0.13722556829452515,
0.03375374153256416,
0.23788298666477203,
-0.03585771098732948,
0.13733802735805511
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. form"). They should not be confused with prominent plantar or palmar wrinkling seen in other forms of overgrowth (see Sapp et al for photographic examples of lesions with similar appearance to a CCTN). CCTNs rarely progress in adulthood . The sulci of CCTNs commonly get deep enough in late adolescence to pose challenges with cleanliness and malodor.Linear verrucous epidermal nevi are streaky, pigmented, rough nevi that often follow the lines of Blaschko. They can be present anywhere on the body. They are most commonly recognized in the first months of life and are generally stable over time .Overgrowth of lipomatous tissue / lipoatrophy. It is common for individuals to manifest overgrowth of adipose tissue, most commonly in infancy. Overgrowth of adipose tissue can continue to appear in novel locations throughout childhood and into young adulthood. Similarly, many individuals with PS experience marked regional lipoatrophy, and many manifest both | [
-0.10970212519168854,
-0.18018554151058197,
-0.0008130757487379014,
0.14903686940670013,
0.0826229453086853,
-0.29457327723503113,
-0.037772420793771744,
-0.023965930566191673,
-0.23462197184562683,
-0.02044723555445671,
0.2866581380367279,
0.05283958464860916,
-0.1285114884376526,
-0.06484579294919968,
-0.08277808129787445,
0.16348622739315033,
-0.13357524573802948,
-0.0038274244870990515,
0.058138683438301086,
-0.07613503932952881,
-0.010223965160548687,
-0.0754120945930481,
-0.01328717079013586,
0.07701050490140915,
-0.1342685967683792,
0.048929937183856964,
0.10518641769886017,
0.25005584955215454,
0.015309437178075314,
0.04448860138654709,
-0.12190572917461395,
-0.028670182451605797,
-0.0497547909617424,
-0.07781551778316498,
0.32626619935035706,
-0.1561584770679474,
-0.2029411792755127,
-0.005593132693320513,
-0.0022545575629919767,
0.07303173840045929,
0.1443043202161789,
-0.016427764669060707,
-0.3849169611930847,
-0.23929183185100555,
0.06660948693752289,
-0.09537138044834137,
-0.11374404281377792,
0.16397204995155334,
-0.1144886165857315,
0.18293505907058716,
0.16405121982097626,
-0.16829898953437805,
0.08614859730005264,
0.15492871403694153,
0.12132438272237778,
-0.02530624344944954,
-0.08541496843099594,
-0.061801664531230927,
-0.30665040016174316,
0.020477861166000366,
0.25390496850013733,
-0.01710265316069126,
0.10077270865440369,
-0.46095582842826843,
0.1348147839307785,
-0.050017524510622025,
-0.08767222613096237,
0.14569944143295288,
0.13058140873908997,
0.08712160587310791,
0.3578090965747833,
-0.37362393736839294,
-0.19043999910354614,
-0.12308365851640701,
-0.2260086089372635,
-0.15446460247039795,
0.10778001695871353,
-0.26442191004753113,
-0.04740511253476143,
-0.16818512976169586,
-0.07085154950618744,
-0.11361859738826752,
-0.17009615898132324,
0.18379342555999756,
-0.34801021218299866,
-0.13341768085956573,
0.08323216438293457,
0.09156090021133423,
0.06635970622301102,
0.05700413137674332,
-0.10407482832670212,
0.0759853646159172,
-0.2048874795436859,
0.08733022212982178,
-0.09701152890920639,
-0.26562294363975525,
-0.02859012596309185,
-0.07925612479448318,
-0.08857525140047073,
0.042618777602910995,
0.035991422832012177,
0.22782054543495178,
0.0026386647950857878,
-0.16779397428035736,
0.03989088162779808,
-0.010872012004256248,
-0.18233786523342133,
0.15367338061332703,
-0.06954837590456009,
0.07706142216920853,
-0.14185340702533722,
-0.19135065376758575,
-0.16285288333892822,
-0.16821281611919403,
-0.35018521547317505,
-0.0716555044054985,
0.12115956842899323,
0.02138070948421955,
0.015849465504288673,
-0.20949843525886536,
0.052697230130434036,
-0.03363722935318947,
0.15242153406143188,
-0.03087133914232254,
-0.013936221599578857,
0.00025258350069634616,
0.2703929841518402,
-0.2534445524215698,
-0.09713464975357056,
0.000004827698376175249,
0.09419503808021545,
-0.04778441786766052,
-0.04520200192928314,
-0.3061217665672302,
0.16546368598937988,
0.12010606378316879,
-0.13152700662612915,
-0.05741874873638153,
0.0011232866672798991,
-0.1547161489725113,
0.09441570192575455,
0.01871904917061329,
0.2554527819156647,
0.11186457425355911,
0.053919848054647446,
0.07757504284381866,
0.10903923958539963,
0.023650512099266052,
0.0995340645313263,
-0.18892551958560944,
0.10207071155309677,
-0.03236361965537071,
0.3474990129470825,
-0.0654241219162941,
0.13349756598472595,
0.3708610236644745,
-0.13354520499706268,
0.10029486566781998,
-0.23401184380054474,
-0.06476008892059326,
-0.08218873292207718,
-0.08158550411462784,
-0.061820872128009796,
-0.122974693775177,
-0.07037793099880219,
0.23680773377418518,
-0.3031207025051117,
-0.4560290575027466,
0.055045999586582184,
0.29335716366767883,
-0.13771753013134003,
-0.013271206989884377,
-0.08353117108345032,
0.12255670130252838,
-0.10955709218978882,
-0.07895718514919281,
0.16117006540298462,
0.07814636826515198,
-0.07218670099973679,
0.29972657561302185,
0.21424351632595062,
-0.17243322730064392,
0.03565225377678871,
-0.07574174553155899,
0.0890788584947586,
-0.12859927117824554,
-0.12623335421085358,
0.22138287127017975,
-0.21955272555351257,
-0.09854844212532043,
0.1609634906053543,
0.01777433417737484,
-0.12682566046714783,
-0.1371898651123047,
-0.15992498397827148,
-0.36692774295806885,
-0.18118931353092194,
-0.11324911564588547,
0.25132954120635986,
0.08733171224594116,
-0.08661918342113495,
0.0909370705485344,
0.1620720624923706,
0.028662582859396935,
-0.05270753428339958,
0.11138194799423218,
0.08733394742012024,
-0.232766792178154,
0.04155540466308594,
0.19969815015792847,
0.11151682585477829,
0.25404849648475647,
-0.014934740960597992,
-0.17488184571266174,
-0.023534012958407402,
0.12676481902599335,
-0.049960941076278687,
-0.041993770748376846,
-0.010656118392944336,
0.06819978356361389,
-0.07501482963562012,
0.11422202736139297,
0.11920185387134552,
-0.19520193338394165,
-0.24697455763816833,
0.13247939944267273,
0.0955113098025322,
-0.012405489571392536,
0.1931120753288269,
0.06071663275361061,
-0.011991819366812706,
0.16780991852283478,
-0.051641132682561874,
0.024120936170220375,
0.09175734966993332,
-0.0970684066414833,
0.28545865416526794,
0.10240001231431961,
-0.09049160033464432,
0.1404678374528885,
-0.22050543129444122,
-0.02661067061126232,
-0.02598760463297367,
-0.25588852167129517,
-0.06287721544504166,
0.13926242291927338,
-0.0013666937593370676,
-0.126548171043396,
-0.0789116621017456,
0.06382506340742111,
0.003924067132174969,
-0.1960114985704422,
0.12869809567928314,
0.06321144104003906,
-0.4245505928993225,
-0.09493061155080795,
-0.05397140979766846,
-0.08701247721910477,
0.13049310445785522,
0.24896077811717987,
0.21106760203838348,
0.3103196918964386,
0.11375083029270172,
-0.08092554658651352,
-0.12893466651439667,
-0.20819859206676483,
-0.028517311438918114,
0.14761410653591156,
-0.13170696794986725,
-0.38012561202049255,
-0.18125146627426147,
0.12863513827323914,
0.13794615864753723,
0.006320756860077381,
0.14373661577701569,
0.12985824048519135,
0.21237105131149292,
-0.04401211440563202,
0.16535750031471252,
0.13704553246498108,
0.04058747738599777,
0.06412403285503387,
-0.08852092921733856,
-0.016085121780633926,
0.37663668394088745,
0.22097252309322357,
-0.32373982667922974,
0.1857864409685135,
-0.04772757738828659,
-0.03104313649237156,
-0.140889972448349,
-0.016620298847556114,
0.2597477436065674,
-0.03661946952342987,
0.025109075009822845,
0.31318819522857666,
0.06046094745397568,
-0.07606969028711319,
0.10004684329032898,
0.06986863911151886,
0.10665572434663773,
0.14237669110298157,
-0.10277774184942245,
0.12531206011772156,
0.03857853636145592,
-0.13842928409576416,
0.05979502201080322,
-0.014382654801011086,
0.005342484917491674,
-0.2901704013347626,
0.10007069259881973,
-0.12159249931573868,
0.09495896100997925,
0.05839662626385689,
0.20737503468990326,
-0.08641170710325241,
0.1268721967935562,
-0.015060692094266415,
0.2629659175872803,
-0.027661923319101334,
-0.003216491313651204,
-0.041679006069898605,
-0.03560464456677437,
0.19799089431762695,
-0.01959168165922165,
0.0937240943312645,
-0.046572569757699966,
0.282410591840744,
-0.2820361256599426,
0.14697536826133728,
0.023851320147514343,
0.19249370694160461,
0.06918232142925262,
-0.21158427000045776,
-0.01634054258465767,
-0.059173427522182465,
0.023831963539123535,
-0.12030021846294403,
0.21030212938785553,
-0.025380808860063553,
0.17048078775405884,
-0.3596595525741577,
0.0074729351326823235,
-0.14682802557945251,
0.08752191811800003,
-0.13782089948654175,
0.1918898969888687,
0.062300436198711395,
0.014950660057365894,
0.01240565162152052,
-0.0910731703042984,
-0.18112950026988983,
0.002920181956142187,
-0.16538859903812408,
-0.047527022659778595,
0.056243352591991425,
-0.0191749669611454,
-0.030472267419099808,
0.005102489143610001,
0.041698433458805084,
0.04751436784863472,
-0.14394500851631165,
-0.3441717326641083,
-0.15017886459827423,
-0.3164520561695099,
0.029930930584669113,
-0.3143046796321869,
0.03506651893258095,
0.2604488730430603,
-0.1348850578069687,
0.48570185899734497,
0.03939930722117424,
0.09505792707204819,
-0.06714621186256409,
-0.14392566680908203,
0.07509646564722061,
-0.20805533230304718,
0.007702328264713287,
-0.10785180330276489,
-0.19618473947048187,
-0.0883755013346672,
0.32772982120513916,
0.14184607565402985,
-0.16606517136096954,
-0.12340180575847626,
0.09303172677755356,
-0.19095110893249512,
-0.07681955397129059,
-0.01719958521425724,
-0.29519450664520264,
0.12488017976284027,
-0.022822583094239235,
0.03141956776380539,
0.31659820675849915,
0.13220617175102234,
0.053434643894433975,
-0.06538010388612747,
0.01437609177082777,
-0.28401365876197815,
-0.053074244409799576,
-0.3523101508617401,
0.16878363490104675,
0.2270621806383133,
0.07837633788585663,
0.10916516929864883,
0.1965932995080948,
-0.06877502053976059,
-0.037697069346904755,
-0.04756113886833191,
0.21233420073986053,
-0.09177737683057785,
-0.10537957400083542,
0.058493394404649734,
-0.1002054214477539,
-0.20823006331920624,
-0.06486327946186066,
0.21202106773853302,
0.16261570155620575,
0.00928591750562191,
-0.05117853358387947,
0.12913385033607483,
-0.19641046226024628,
-0.047076597809791565,
0.10547368973493576,
-0.23443980515003204,
0.12029359489679337,
0.2050050050020218,
0.12587575614452362,
0.0536254458129406,
0.18508979678153992,
0.08621151745319366,
-0.23322468996047974,
-0.2793431282043457,
0.04241730272769928,
0.16797472536563873,
0.08084041625261307,
-0.0028977743349969387,
-0.07296987622976303,
0.17284056544303894,
0.09627893567085266,
0.24186299741268158,
0.031262680888175964,
0.102081798017025,
-0.04139336198568344,
0.02871100604534149,
0.08164031058549881,
-0.07332246750593185,
-0.02000967040657997,
-0.33814266324043274,
-0.11043459177017212,
-0.09666735678911209,
-0.0032644181046634912,
0.10789371281862259,
0.05303894355893135,
0.3263307511806488,
0.0880291536450386,
0.0366407074034214,
0.06365969777107239,
-0.10512569546699524,
0.16449332237243652,
0.13494890928268433,
0.05651957541704178,
0.03958692029118538,
0.13167746365070343,
0.14813239872455597,
0.23231163620948792,
-0.12924809753894806,
-0.07746972888708115,
0.08511076122522354,
0.007408946752548218,
0.08568726480007172,
0.15957695245742798,
0.1227487176656723,
-0.1764121800661087,
-0.08443772792816162,
-0.005271376576274633,
-0.0026387106627225876,
-0.04300268739461899,
0.07340874522924423,
0.20849764347076416,
0.3146745562553406,
0.19116449356079102,
0.2582625448703766,
-0.11084603518247604,
0.07792234420776367,
0.22251243889331818,
0.14052605628967285,
0.04703297093510628,
0.4094010889530182,
0.013852073810994625,
0.13407330214977264,
0.1909097135066986,
0.04840412735939026,
0.3310210704803467,
0.16476909816265106,
0.16874323785305023,
0.0029258192516863346,
-0.034668151289224625,
-0.04851440340280533,
-0.4358583688735962,
0.18925869464874268,
-0.05105499178171158,
0.049560870975255966,
-0.053365059196949005,
0.27441319823265076,
-0.09771612286567688,
-0.1119898110628128,
-0.3897222876548767,
0.09869279712438583,
-0.17720386385917664,
-0.09691929817199707,
-0.05626211315393448,
-0.1657169759273529,
-0.12545832991600037,
0.03506318852305412,
-0.1594432294368744,
-0.1660148799419403,
0.13384278118610382,
0.12055628001689911,
-0.056750912219285965,
-0.24778558313846588,
-0.2798217833042145,
0.08593352138996124,
-0.04588087275624275,
-0.028025178238749504,
0.12095938622951508,
-0.16982947289943695,
0.16056181490421295,
-0.0364958681166172,
0.01164946984499693,
-0.24952703714370728,
0.06771750748157501,
-0.0675312727689743,
0.05748111382126808,
-0.02365732565522194,
-0.2877236604690552,
0.019463296979665756,
0.014024592936038971,
-0.025365618988871574,
0.13521982729434967,
-0.10791545361280441,
0.30441761016845703,
0.15295325219631195,
0.24833591282367706,
-0.118754081428051,
-0.054453253746032715,
0.026926672086119652,
0.05569677799940109,
0.04389927536249161,
-0.08620842546224594,
0.024755485355854034,
-0.19973528385162354,
-0.07989949733018875,
-0.11896942555904388,
-0.12321874499320984,
-0.03800042346119881,
0.11665108799934387,
-0.030875928699970245,
0.0558021180331707,
0.2979710102081299,
-0.18363025784492493,
-0.0008941762498579919,
0.03712664917111397,
-0.2026975452899933,
0.0444110669195652,
0.19065575301647186,
0.20311769843101501,
0.29710814356803894,
-0.05347595736384392,
-0.08105269819498062,
-0.18887317180633545,
-0.14318832755088806,
0.19404996931552887,
-0.31149381399154663,
0.031545188277959824,
-0.08522544801235199,
-0.14240910112857819,
-0.20066292583942413,
-0.3322201669216156,
-0.10546176135540009,
0.12372743338346481,
-0.05457604303956032,
-0.06908223778009415,
0.06052028015255928,
0.22345075011253357,
0.1097104400396347,
-0.12440541386604309,
0.22199012339115143,
0.41643792390823364,
-0.10013063251972198,
0.1521667242050171,
0.05849480628967285,
-0.023957092314958572,
0.009820199571549892,
0.005107376724481583,
0.23550651967525482,
0.10034893453121185,
-0.17868313193321228,
0.07620098441839218,
0.20126990973949432,
0.02643890306353569,
0.06410446017980576,
0.02908005192875862,
-0.17311762273311615,
0.05204048380255699,
0.13141390681266785,
0.14078746736049652,
-0.3567425310611725,
0.07924658060073853,
0.08423501253128052,
-0.16883808374404907,
-0.4055333435535431,
0.12466789036989212,
0.0348912850022316,
0.1820148527622223,
-0.42203289270401,
0.15897157788276672,
0.10951673984527588,
0.1261441558599472,
0.17354345321655273,
0.2641139626502991,
-0.14263321459293365,
0.06601690500974655,
-0.13424402475357056,
0.03884102776646614,
0.20969758927822113,
0.1199209913611412,
-0.24431930482387543,
0.12982100248336792,
0.10465304553508759,
-0.10625618696212769,
-0.24343714118003845,
-0.027523227035999298,
-0.020800093188881874,
0.049703724682331085,
0.14107860624790192,
-0.02024780586361885,
0.011655045673251152,
0.02194320410490036,
-0.00421629985794425,
0.08207789808511734,
0.0487087108194828,
0.13038590550422668,
0.28422555327415466,
-0.07815153151750565,
0.22946344316005707,
0.03088480792939663,
-0.07726290076971054,
-0.07060622423887253,
-0.33608880639076233,
0.1316024363040924,
0.10897082090377808,
-0.10228231549263,
0.11104676127433777,
-0.16218571364879608,
-0.13015641272068024,
0.04430622234940529,
0.11967480182647705,
0.018862951546907425,
-0.2109740674495697,
-0.005301939323544502,
0.14130215346813202,
-0.17430807650089264,
0.07552390545606613,
-0.12745921313762665,
0.12445381283760071,
-0.08877330273389816,
-0.1061231717467308,
-0.11989761143922806,
-0.18868696689605713,
-0.45251134037971497,
-0.0795445367693901,
-0.015338916331529617,
0.18489286303520203,
-0.0006984425126574934,
-0.010735560208559036,
0.019644668325781822,
-0.3029120862483978,
0.10691781342029572,
0.22594016790390015,
-0.10436653345823288,
-0.30274131894111633,
-0.22956468164920807,
-0.35295477509498596,
0.2789306640625,
-0.08150195330381393,
-0.0742919072508812,
0.03562895208597183,
0.27544182538986206,
-0.003331555286422372,
-0.03378429636359215,
0.1123647689819336,
-0.07972361147403717,
-0.14848309755325317,
0.05308784916996956,
-0.06675926595926285,
0.45425140857696533,
0.016481420025229454,
-0.24720366299152374,
0.046561889350414276,
-0.12680283188819885,
-0.030328601598739624,
-0.06857645511627197,
0.10609601438045502,
0.22321206331253052,
-0.3456547260284424,
0.01039945613592863,
-0.22037048637866974,
-0.14384789764881134,
-0.048080697655677795,
-0.020556407049298286,
0.024146616458892822,
-0.11769187450408936,
-0.008131907321512699,
0.2719621956348419,
-0.018088921904563904,
-0.18238350749015808,
-0.2107919305562973,
-0.2192566692829132,
-0.15700526535511017,
-0.05710562691092491,
-0.32091447710990906,
-0.11517038196325302,
-0.07089285552501678,
-0.01664127968251705,
-0.05896790698170662,
0.009263901039958,
-0.3364039659500122,
0.08390432596206665,
0.029483873397111893,
0.07223019003868103,
-0.04121899604797363,
-0.08234743028879166,
0.12888799607753754,
-0.12146898359060287,
-0.18824566900730133,
-0.1063033789396286,
-0.038391925394535065,
-0.4270906150341034,
-0.1586454212665558,
-0.0070362635888159275,
-0.10212172567844391,
-0.09329602122306824,
0.1853172481060028,
-0.06351716071367264,
-0.06911497563123703,
-0.07117122411727905,
0.12725575268268585,
0.03666413202881813,
-0.03525447100400925,
0.0040395138785243034,
-0.05479475483298302,
0.18583934009075165,
0.03243258222937584,
0.061919908970594406,
-0.19941392540931702,
-0.14986762404441833,
-0.031012285500764847,
-0.11903832107782364,
0.01789354719221592,
-0.38013020157814026,
-0.28233441710472107,
0.10968966782093048,
0.10114818811416626,
-0.01544217113405466,
-0.08861702680587769,
-0.010921391658484936,
0.2833035886287689
] |
gene_reviews | https://www.ncbi.nlm.nih.gov/books/NBK99495/ | JOqrnDM | Proteus Syndrome | C0085261 | 31,761 | proteus syndrome. Blaschko. They can be present anywhere on the body. They are most commonly recognized in the first months of life and are generally stable over time .Overgrowth of lipomatous tissue / lipoatrophy. It is common for individuals to manifest overgrowth of adipose tissue, most commonly in infancy. Overgrowth of adipose tissue can continue to appear in novel locations throughout childhood and into young adulthood. Similarly, many individuals with PS experience marked regional lipoatrophy, and many manifest both regional lipomatous overgrowth and lipoatrophy. Persons with PS do not have the typical ovoid, encapsulated lipomas common in the elderly and so the term "lipoma" is technically incorrect, but in wide usage. Fatty infiltration of the myocardium, particularly the intraventicular septum, has been observed in a number of children and adults with PS with no functional consequences .Vascular malformations. Many individuals with PS have cutaneous capillary malformations and prominent venous patterning or varicosities | [
0.02919301576912403,
-0.09306620061397552,
-0.05100470036268234,
-0.0039995647966861725,
0.16897469758987427,
-0.20123469829559326,
0.11980756372213364,
-0.0799870416522026,
-0.026212576776742935,
0.19667266309261322,
0.1321098953485489,
0.2389185130596161,
-0.022312983870506287,
0.06380076706409454,
-0.08057805150747299,
-0.009467660449445248,
-0.1472029834985733,
-0.18117819726467133,
-0.02755071222782135,
0.036809634417295456,
0.06179698929190636,
-0.22426201403141022,
0.05923781543970108,
0.089797742664814,
0.12025870382785797,
-0.020926322788000107,
0.3211332857608795,
0.297843337059021,
0.01674552820622921,
0.02788199856877327,
-0.024411235004663467,
-0.0751078650355339,
-0.1023227646946907,
-0.2968076467514038,
0.30290985107421875,
-0.2102893888950348,
-0.19981905817985535,
0.0518585629761219,
0.052759669721126556,
0.0039021684788167477,
-0.07461756467819214,
0.1593404859304428,
-0.11245615780353546,
-0.08297153562307358,
0.15289972722530365,
-0.07045011967420578,
0.10918397456407547,
0.07892315834760666,
0.021545084193348885,
0.20907482504844666,
0.2547760605812073,
-0.12910105288028717,
0.016722600907087326,
0.055797260254621506,
0.2081681787967682,
-0.08755001425743103,
0.08645080029964447,
-0.03249111399054527,
-0.23990562558174133,
0.06452007591724396,
0.1817137598991394,
0.008674882352352142,
0.18558529019355774,
-0.3577837347984314,
0.10434980690479279,
-0.08226612210273743,
-0.04750020429491997,
0.18348003923892975,
0.054514992982149124,
0.12961754202842712,
0.4859958291053772,
-0.25176048278808594,
-0.026889201253652573,
-0.12176336348056793,
-0.012980915606021881,
0.0435611717402935,
0.20316724479198456,
-0.3137877583503723,
-0.19644813239574432,
-0.19792033731937408,
0.11216761916875839,
0.08933930844068527,
0.0017515742219984531,
0.07255708426237106,
-0.2451857626438141,
-0.12550145387649536,
-0.006023897789418697,
0.04557042196393013,
-0.05762381851673126,
-0.03704051673412323,
-0.02810930833220482,
0.07432685792446136,
0.03922067582607269,
0.19323407113552094,
-0.009415347129106522,
-0.14089740812778473,
-0.030760644003748894,
-0.002321704290807247,
-0.14491264522075653,
0.02003829926252365,
0.2489071935415268,
0.30101847648620605,
-0.034659188240766525,
-0.08793819695711136,
0.08734416216611862,
-0.10979841649532318,
-0.17486800253391266,
0.11935926228761673,
0.09467844665050507,
0.08977580815553665,
-0.14187787473201752,
-0.12782400846481323,
-0.027563441544771194,
-0.2030647248029709,
-0.3097102642059326,
0.0796455591917038,
0.110625721514225,
0.02389954961836338,
0.009439869783818722,
-0.17083221673965454,
0.03212220221757889,
-0.021781323477625847,
0.04112173989415169,
0.05626720190048218,
0.09039276093244553,
0.08122774958610535,
0.2706282138824463,
-0.06647203862667084,
0.03402597829699516,
-0.11142222583293915,
0.10147305577993393,
-0.07809703052043915,
-0.12525306642055511,
-0.20525750517845154,
0.0811726525425911,
0.1511414647102356,
-0.23364955186843872,
0.006052736658602953,
0.06105337291955948,
-0.11734086275100708,
0.13784268498420715,
0.002789952326565981,
0.4160788357257843,
0.09179505705833435,
-0.04170232638716698,
0.05366562306880951,
0.24310751259326935,
0.12431500852108002,
0.18309202790260315,
-0.09009191393852234,
0.30377325415611267,
-0.21860428154468536,
0.09080319851636887,
-0.0023892889730632305,
-0.0669940710067749,
0.03088790364563465,
-0.02612322010099888,
-0.060452960431575775,
-0.20674321055412292,
-0.19304265081882477,
-0.02323387935757637,
-0.12614071369171143,
0.03533966839313507,
-0.17285707592964172,
-0.23958435654640198,
0.18491563200950623,
-0.07689067721366882,
-0.1260184645652771,
0.06968970596790314,
0.1668514460325241,
-0.03164851665496826,
0.1415334790945053,
-0.17917132377624512,
-0.15607821941375732,
-0.10152533650398254,
0.08263304829597473,
0.12012466043233871,
0.06656559556722641,
-0.06283465772867203,
0.15536372363567352,
0.20827127993106842,
-0.09743595123291016,
0.06694340705871582,
-0.21176455914974213,
-0.006546089891344309,
-0.2561747133731842,
-0.1273176223039627,
0.3169328570365906,
-0.14883911609649658,
0.07719804346561432,
0.10506151616573334,
-0.03683348745107651,
-0.059764932841062546,
0.08158361166715622,
-0.11218027770519257,
-0.26180532574653625,
-0.12148050963878632,
-0.0640484094619751,
0.18615703284740448,
0.07530029863119125,
0.03444627299904823,
0.04401523247361183,
0.14687258005142212,
0.03678007796406746,
0.05203484743833542,
-0.030702123418450356,
0.1222231462597847,
-0.2093086987733841,
0.0977097675204277,
0.06982458382844925,
-0.03179540857672691,
0.2644234001636505,
-0.029715802520513535,
-0.11236193776130676,
0.038440804928541183,
-0.0649525448679924,
-0.12464222311973572,
-0.10737384855747223,
-0.012934111058712006,
0.17633503675460815,
-0.15969614684581757,
0.2207053154706955,
-0.13141793012619019,
-0.19416765868663788,
-0.3858911991119385,
0.11225314438343048,
-0.030450351536273956,
0.007989753969013691,
-0.02606561779975891,
0.0614963173866272,
-0.049777477979660034,
-0.003653522115200758,
0.03068111091852188,
0.0991406962275505,
-0.07894625514745712,
-0.3324279487133026,
-0.07748047262430191,
0.19635888934135437,
-0.13986019790172577,
0.2847074270248413,
-0.13100159168243408,
-0.0692620575428009,
0.061184387654066086,
-0.19283325970172882,
-0.1071721687912941,
0.09168324619531631,
0.04345479980111122,
-0.03210338205099106,
-0.08294083923101425,
0.07951530069112778,
-0.04014122113585472,
-0.18458501994609833,
0.24189113080501556,
0.06973845511674881,
-0.2599077522754669,
-0.011372809298336506,
0.01902811788022518,
-0.04911426827311516,
0.05424090847373009,
0.1299387812614441,
0.07697030901908875,
0.266597181558609,
0.10926949977874756,
-0.2372456192970276,
-0.39046937227249146,
-0.37102261185646057,
-0.1979018896818161,
0.12794433534145355,
-0.15826545655727386,
-0.31922611594200134,
-0.18450549244880676,
0.14834700524806976,
0.14865271747112274,
-0.11284336447715759,
0.13054205477237701,
0.23000717163085938,
0.022164739668369293,
0.09107991307973862,
0.16645096242427826,
-0.055079616606235504,
0.03838091716170311,
0.08313949406147003,
-0.04500894248485565,
-0.09589064121246338,
0.3680802285671234,
0.07161913067102432,
-0.260986864566803,
0.18897418677806854,
0.05810658261179924,
-0.06963510811328888,
0.06088300421833992,
0.0785871148109436,
0.06149837002158165,
-0.05236288905143738,
0.1098446175456047,
0.29476097226142883,
-0.12679322063922882,
-0.10520951449871063,
0.14750859141349792,
0.09771181643009186,
0.018071742728352547,
0.19333820044994354,
-0.24784305691719055,
0.030084284022450447,
0.21749518811702728,
-0.03220062330365181,
0.09299015998840332,
0.13693027198314667,
-0.09320465475320816,
-0.21230529248714447,
-0.19007782638072968,
0.019111422821879387,
0.06995364278554916,
0.11297638714313507,
0.09560004621744156,
-0.037548914551734924,
-0.05953375995159149,
0.03368168696761131,
0.15175482630729675,
-0.07434852421283722,
0.11875959485769272,
0.037263210862874985,
-0.0767148956656456,
0.05880638584494591,
-0.032512251287698746,
0.060236070305109024,
0.09042825549840927,
0.2943195104598999,
-0.07165983319282532,
-0.015352580696344376,
0.2385120540857315,
0.06185141205787659,
-0.06544595211744308,
-0.2324865758419037,
0.0208694189786911,
-0.006533234380185604,
0.1414535790681839,
-0.03497380018234253,
0.08954469859600067,
-0.02407013811171055,
-0.052199915051460266,
-0.2407996952533722,
0.07750525325536728,
-0.1781686693429947,
0.07871546596288681,
0.0392429381608963,
0.06352608650922775,
0.14406992495059967,
-0.06161753088235855,
-0.13262566924095154,
-0.15115907788276672,
-0.14773492515087128,
0.15112599730491638,
-0.16279488801956177,
0.06495688855648041,
0.118618443608284,
0.10728341341018677,
0.04135450720787048,
-0.10224379599094391,
0.06360380351543427,
-0.021819299086928368,
0.08062121272087097,
-0.2612338066101074,
-0.15502719581127167,
-0.27322569489479065,
0.12222222238779068,
-0.1840810626745224,
-0.10681714117527008,
0.19334374368190765,
-0.153538778424263,
0.43513572216033936,
0.12261707335710526,
-0.15308921039104462,
-0.0993943139910698,
-0.039060626178979874,
0.060693319886922836,
-0.2888530492782593,
-0.01999587193131447,
-0.14085403084754944,
-0.18841469287872314,
-0.2119818925857544,
0.1846308410167694,
0.23293226957321167,
0.034700389951467514,
-0.009330952540040016,
-0.1181560754776001,
-0.20437096059322357,
0.03243378549814224,
-0.03130873665213585,
-0.21884463727474213,
0.18456293642520905,
0.1569434106349945,
-0.03548251464962959,
0.3135571777820587,
-0.00451231375336647,
-0.03564785048365593,
0.015044319443404675,
0.11364131420850754,
-0.29658371210098267,
0.22159889340400696,
-0.15672525763511658,
0.1203756257891655,
0.2999071180820465,
0.1867634356021881,
0.10825098305940628,
0.10749742388725281,
-0.1499624103307724,
0.07229924201965332,
0.007452051155269146,
0.32881975173950195,
-0.14365243911743164,
-0.04128391668200493,
0.10099241882562637,
-0.06957649439573288,
-0.2662217915058136,
-0.13189756870269775,
0.08102715015411377,
0.023806191980838776,
0.07146536558866501,
-0.17107179760932922,
0.04465002939105034,
-0.09799709171056747,
0.1852523535490036,
0.154361292719841,
-0.21680226922035217,
0.00192463758867234,
0.05138193443417549,
0.2143225073814392,
-0.027016211301088333,
0.2675829827785492,
0.3177967369556427,
-0.2783504128456116,
-0.34060603380203247,
0.11884631216526031,
0.16357295215129852,
0.06191130727529526,
0.0837741270661354,
0.18255026638507843,
0.07992258667945862,
-0.02497692219913006,
0.346046507358551,
0.0640627071261406,
0.15244588255882263,
0.08208601176738739,
-0.15965591371059418,
0.12187248468399048,
0.15078338980674744,
-0.0364762619137764,
-0.07109124213457108,
0.1139129102230072,
-0.13087961077690125,
0.02151261456310749,
-0.00779772037640214,
0.06789317727088928,
0.2822153568267822,
0.19029273092746735,
-0.1482224017381668,
0.12096820771694183,
-0.07098239660263062,
0.2663397789001465,
0.09027033299207687,
0.14703847467899323,
0.13784442842006683,
0.15978233516216278,
0.046586766839027405,
0.014178335666656494,
-0.27997487783432007,
0.029583267867565155,
0.04895477741956711,
0.03112356923520565,
-0.013164605014026165,
-0.034022729843854904,
-0.03130481019616127,
-0.12625013291835785,
-0.022031186148524284,
-0.030575213953852654,
-0.15715305507183075,
0.1910714954137802,
-0.29915937781333923,
0.16999559104442596,
0.29372942447662354,
0.00713681522756815,
-0.018155910074710846,
-0.07863333821296692,
0.018041422590613365,
0.1490233838558197,
0.08474961668252945,
-0.11138349771499634,
0.4473274052143097,
0.03914831206202507,
0.15190701186656952,
0.009447180666029453,
0.04819289222359657,
0.2964552640914917,
0.18584448099136353,
0.007492887321859598,
0.19479866325855255,
-0.051584403961896896,
-0.1513235867023468,
-0.26249292492866516,
-0.08332179486751556,
0.04468163102865219,
-0.07772832363843918,
0.08530784398317337,
-0.008156164549291134,
-0.039057500660419464,
-0.04886963590979576,
-0.34417927265167236,
0.019420916214585304,
0.11893123388290405,
0.0057456158101558685,
-0.10794311761856079,
0.20808973908424377,
0.10901841521263123,
-0.014319614507257938,
0.006923360284417868,
-0.12414748221635818,
0.1762271523475647,
0.038748640567064285,
-0.16638962924480438,
0.021967396140098572,
-0.0968974232673645,
0.13082247972488403,
0.19793188571929932,
-0.017926976084709167,
0.033284544944763184,
-0.22233515977859497,
0.25792378187179565,
0.021431636065244675,
0.013125221244990826,
-0.12528681755065918,
0.0817011371254921,
0.12733690440654755,
0.1337602436542511,
-0.019400810822844505,
0.06313639134168625,
-0.07221798598766327,
-0.16826072335243225,
0.04888176918029785,
0.1711423397064209,
-0.1356106549501419,
0.20950756967067719,
0.17491944134235382,
0.09236903488636017,
-0.0152854910120368,
0.14990703761577606,
0.18159575760364532,
-0.01724967733025551,
-0.08056765049695969,
0.360625684261322,
0.17605942487716675,
-0.14361225068569183,
-0.1361740380525589,
-0.06022043526172638,
-0.17669785022735596,
-0.01147498656064272,
0.24062499403953552,
0.05438863858580589,
0.0841769129037857,
0.37564992904663086,
-0.20318984985351562,
0.049592114984989166,
-0.11442629992961884,
-0.04736822471022606,
0.08147188276052475,
0.2414471060037613,
0.3666229248046875,
0.08286438882350922,
0.10814126580953598,
-0.10997597128152847,
-0.06592725217342377,
-0.1042218878865242,
0.2190832793712616,
-0.06272362172603607,
-0.3243078589439392,
0.06962713599205017,
-0.14734064042568207,
-0.10300544649362564,
-0.17516064643859863,
0.12001225352287292,
0.2116849571466446,
-0.26485273241996765,
-0.14376802742481232,
0.05940461531281471,
0.1576516479253769,
0.010105893015861511,
0.01445561833679676,
0.14686395227909088,
0.34351280331611633,
0.07050423324108124,
-0.06512521207332611,
-0.08055554330348969,
0.11482316255569458,
-0.12873999774456024,
0.0644572526216507,
0.057788580656051636,
-0.0028214408084750175,
-0.013214650563895702,
-0.003277305280789733,
0.054267581552267075,
0.10353110730648041,
0.02250712737441063,
-0.06571386009454727,
-0.28498220443725586,
-0.19583219289779663,
0.022223155945539474,
0.17307282984256744,
-0.2545156478881836,
0.23375192284584045,
0.04340660199522972,
-0.11694192886352539,
-0.16940774023532867,
0.20296747982501984,
0.13383348286151886,
0.18043848872184753,
-0.21478798985481262,
0.09547443687915802,
-0.09696231782436371,
0.2001437544822693,
0.013908413238823414,
0.33378490805625916,
-0.04877936467528343,
0.07259877771139145,
-0.08232565969228745,
-0.019330736249685287,
0.22945266962051392,
-0.23034153878688812,
-0.09866239875555038,
0.20369096100330353,
0.05009519308805466,
-0.0766536295413971,
-0.19374944269657135,
-0.014101061038672924,
0.0930243656039238,
-0.06290364265441895,
0.1488344818353653,
0.17690995335578918,
-0.1584312617778778,
-0.12932786345481873,
-0.2294294834136963,
0.0677105039358139,
0.03516460955142975,
0.019197937101125717,
0.389171302318573,
-0.12573908269405365,
0.31269147992134094,
-0.06079570949077606,
-0.12031678855419159,
-0.15610139071941376,
-0.3126817047595978,
-0.04024277627468109,
0.19077807664871216,
0.06940684467554092,
0.13350969552993774,
0.11455032229423523,
-0.038303736597299576,
0.11559799313545227,
-0.20247799158096313,
0.07336552441120148,
0.0536351315677166,
-0.25550568103790283,
-0.10468655079603195,
-0.18680723011493683,
-0.02040228061378002,
0.029356541112065315,
0.07779491692781448,
0.0854397565126419,
0.20372088253498077,
-0.1764795184135437,
-0.2207575887441635,
-0.35250186920166016,
0.036748360842466354,
0.25061702728271484,
-0.03760555014014244,
-0.14996226131916046,
0.06453439593315125,
0.003451984142884612,
-0.2846215069293976,
0.19055324792861938,
0.3543301224708557,
0.003610204206779599,
-0.4804975092411041,
-0.13979560136795044,
-0.4148420989513397,
0.10555687546730042,
-0.042532216757535934,
-0.07600533217191696,
0.023327019065618515,
0.28477105498313904,
-0.06178486347198486,
0.003660062327980995,
-0.11365983635187149,
0.07211211323738098,
0.03618442267179489,
-0.03365645185112953,
-0.21492218971252441,
0.22960524260997772,
-0.07955671846866608,
0.013046663254499435,
0.04453502222895622,
-0.07888192683458328,
0.06548868119716644,
-0.14221787452697754,
0.14870432019233704,
0.21754206717014313,
-0.0991169661283493,
-0.0181996189057827,
-0.3794989287853241,
-0.05356213077902794,
-0.15186087787151337,
0.04600692167878151,
0.050482138991355896,
-0.001695650746114552,
0.10366297513246536,
0.11411834508180618,
0.1838551163673401,
-0.2241932898759842,
-0.05379124730825424,
-0.18501794338226318,
-0.02432643249630928,
-0.05734458193182945,
-0.14256227016448975,
-0.034754566848278046,
-0.13973891735076904,
0.06608524918556213,
-0.10639515519142151,
-0.03950654715299606,
-0.13950705528259277,
0.3259029686450958,
0.07087722420692444,
-0.10766775906085968,
-0.1680757850408554,
-0.23599526286125183,
0.18003016710281372,
0.104524165391922,
-0.08867708593606949,
-0.06557531654834747,
0.13639692962169647,
-0.16361886262893677,
-0.11018366366624832,
-0.04263778775930405,
-0.12268964946269989,
-0.1343010663986206,
0.0950874537229538,
-0.023592283949255943,
-0.1866089105606079,
-0.05837211012840271,
-0.013646659441292286,
0.07686171680688858,
-0.21227768063545227,
0.036305394023656845,
-0.01142242643982172,
-0.041606079787015915,
0.1809801608324051,
-0.09865476936101913,
-0.12323039770126343,
-0.19097201526165009,
-0.13100649416446686,
-0.15403655171394348,
0.31641340255737305,
-0.19970518350601196,
-0.3456791937351227,
0.2429223358631134,
0.05380772054195404,
-0.2409883290529251,
0.015536291524767876,
0.05611289292573929,
0.18551389873027802
] |