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[ "See E ee ee Cae Stuay. on the piacevo and\nmemantine proup 33% and 28% received low-dose neuroleptics,\nspectively, stacpeaants weze sed in 5% and sedate\nlypotics in 1% of pacts in each group. Clay the tat\npup was table unl week 26 sod decd in all cine\nstents at eck 82 (42 pints on ADAS-Cog, 1 Son MMSE,\n04-on CDR and I on ADCS-ADL). The S2ueck deine i\ntents on pacho on the ADAS-Cog, MMSE, CDR and ADCS\nADL was 2, 20, 058 and 51 pois, respeciey. With 10,07,\n02 and Spits, the clniel S2ueck decline in study\nsevticionats tance Acs exociomsinn eeee sear", "ee\njicose metabolism from bascline was 2.5% (496%), pO.\nfigafcent renal metabo: medetons were aerhin the\npeal (3.1% (820%), baal ganghonse (27% (600%) and\ntemporal 3% (401%) bain aes (p01 each), Decne in\nhe Font (21% (596%) and cpl (1% (880%) sea\nwere acoriafeant. Langtieal coeptation of sce\nsod S2week follow-up PET studies on MRI rerence ean\nlepicted the dstrintion of functional les overtime. Mos\nAD cass showed a fise glscome metabo. decreas\nvolving all rain arcs, but some, developed sultant\nsymmetie and focally confined reductions in brain metabo\nlam over time (fp 1 A, 8). Memantine tested subjects\nthowed lee nnaaltkelice in coo metallia bri\nares compared ta lake fig 2). The dilfrences wore noe\nigntcant™ In selative tems, the annual decline in lta\njot actabaism in patents on memantine wat 40%\nSees Gas in dois on deme", "BABE & SLOWS BNE CRANBES OF NEN, MONUEREETIE easposnts ower\nime. There was a sgnifeant loss of total brain 2.1% pe yea\np10) sod hippocampal 2.7% pe ea, pe) volumes i\npatients. The annual eduction in total bain vole wa\nmar between the poups (20% placebo vs 23% memantine).\nAt study end, patents on memantine sbowed 106% le\nnppocampl volume reduction than patients on plcebo (2.4%\n“ree", "Mere existed’ no signiicant relationsup Between gona\nchange in glucone metabolism and percentage change in toa\nmain (= ~ 0.02) sna hippocampal (2 = -028) volume Even\nfe ctu with almost comple imponal drop ts ghocz\nmetabo, only minimal sll walening war scent the\nsmal he shen ia Meek chercrinan pedis PR SOA,", "restly due to patient motion dung the 2-min sequstion\nne, Motion ried in acomplia sd ara\nnwt tating in ment eee. Degen on he bs\neqn, many specs wee ealulel fom amly def\npale aay ti dons was ns be bing\nTie Sclaesrate ‘was lowest i she pal cae)\nigi in he cop! (9 cama) bai te. Ana othe\ntng spc al yl sgh itn and ard\narab of al metabole with o cea ends over ine fx\niy patiss ochact nud gations ehyemepa Unta ack acura", "orphologcal neuroimaging feasible in a teatime tl\nments. with modernte AD. This S2wrek study yielded\nfgnfcane reductions tx glucote metabolurn and etal bean\nPd ippocampl snes in group of patents with AD wrth\ndguicine invaldetctoration. Our patent on parts\nowed iar cognitive dnc to tht ported is langeacal\nnial AD tls” and their annual 20% los of toa bai\nsalah oad AGS lem Gf Kdpeccmmesl ctoms sue cle", "ET) rane rtcittnad on aah ete aint tn\nmage (PET) scans rested on Ml an yor fone\npata oho epee od, snot comoie ss a\nuct ston ne tht emptor eon, cote\nreabaism moet ban eps feraned aan unlanged fom\nacon The bee sea deonsvted he pal sya\nenpee paral hpontaolr pets th Aho! disease\nA} The eegstae ites NBL sean sho te, ay Sed\nlarger nthe we fetal oe he pte been\nveauhe (C) and fellve-up 0h.", "iat is is Heels unalone dean Stil elneston aerial orlek\nAD} in 2 S2 wet, randomised, double bing, placebo-cntaed tal on\nte oflect al amenentne om brain morphea, and rotabalam", "al, wich repens a aqucy ard parang\nren \"Grane pens ake Maar Sa", "", "we", "DISCUSSION" ]

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[ "WEN the eelegee of the ‘Choosing Wisely” Top-5 lt of\nstvitles to avoid la 2013\" (Onoha et al. 2014), the\nAmerican Socely of Ancsthesiologists (ASA) identified\nive diagnostic tests or treatments that are commonly\nracticed in the perioperative sting but er Limited to\nno Benelits to patients according to evidence-based\nstudies and may Incr sigaiieant costs to the helt sys\njem\" (Onuoba et a. 20144; Onuoha etal. 2014). Two\naf these items were preoperative recommendations fo\nnusing on unnecessary preoperative testing. They include\nian", "Don't sitein Reseling inborstory siviles in\npatients without sigiicant systemic disease\n[ASA Tor I) undergoing lowers surgery =\npecially complete blood court, base or\ncomprehensive metabolic panel, coagulation\ntudes when blood loss ( Hud shits) are\npected to be minieal, (Onuoha et al 20048\nPecks ok", "Dost shtsin bassline dingnestic canting\nesting (vans thorcielesophageal\n-chocariography ~ TTE/TEB) or cardiac\nire testing in ayrnptomaie stable patents\nwith known cardiac disease (e4. CAD, valvula\nlisease) undergoing low oF moderate risk\nnon-cardiac surgery’ (Austin et al 2014\nBenarroch-Gampel et al. 2012)", "Lica agar im eats dertbel ag Mommeraall\nGampel eal (2012, the authors showed that although\nates testing wer ower inpatients with no combi\nie, aes eerained high, with 54 % of pallets eecelving\nTeast one preoperative test. The overall incidence o\n-omplleatios was less than 1, ad ale contoling fo\npatent comarbidiles and the operative peocedue, nee\nesting noe the presence of abnormal faults were aso\ndated with pestoperave complications. Wilh the com\nination of toute preoperative testing in the sting of\num increasing prevalence of ambulatory surgery, the oh\nination of tirindeated test in low-rk patients woul\npromote patent safety, better quality of eae and res\nsubstantial cost savings (Beowe and Brown 201;\nFleisher LA 2013; Schein et al. 2000).", "TE RRO Re “Ok Demin: Nesting 18, Heenan\npatents has eemalned a hot topic for much over a dec\nde (Benatroch-Gampel eal. 2012; Rolzen 1997; Vogt\nund Henson 1997), In addon, the number of surgi\nprocedures now performed on an outpatient basis co\nines to increase (Flsher LA 2013; Rickman 2010\nestimated that about 30 mallon peopl undergo suger\nually i the USA, of which approximately 6070 ae\nbulatory procedures (Benarroch-Gampel etal 2012\nPesher LA 2015; Richman 2010), Ambulatory procedure\nre often performed is low-sk patens—healhy indi\nals or thow with table conic medial condtions—and\nested to procedures of shart duration with alow ask\nnf intraoperative surgleal complications (Benarroch\nGampel et a. 2012. Despite existing evidence-based\nidles advising the contrary, a baltery of preoperative\ness continue o be performed ia low-risk patents under\njing low-risk ambulatory surgery (Benarroch-Gampel\nal 2012 Brown and Bown 2011; Fisher LA 2013\nchan 2010, Schein eta. 200; Sones De ea. 2015;\nVogt and Henson 1997). Routine preoperative tts when\nperormed in low-sk patents rarely change management\nes auch co 90 cf eee tele 0 at", "While mcet of the body of respanch ditving evidience-\npaved guidlines originate from academe trary isi\ndons, it snot clear whether such istttions adhere to\nhese guidelines, and hence, display a lower incidence o\nerase of preoperative test in lowsk patients under\nging ambulatory surgery than stated in the erature\nTo establish and quantly the incidence of the ordering\nof us-indcated preoperative tests nan academic teria\ntnbustory center, we conducted a retrospective chor\ndy of al paints who underwent outpatient surgery a\nhe Perelman Center for Advanced Medicine (DCAM)\nHospital of the University of Pennsylvania ducing 3\né-month period.", "Ne obtained approval from the anstitutiona’ Review\npour ofthe Perelman School of Medicine, Univer of\nSecaieetie", "Dota was setcacted Som the EPIC medical recente of\n3918 patlents who underwent ambulatory surgery a\nPCAM between the months of November 2012 and\nApril 2013.", "We restricted’ Our sample £0 patients scheduled jor am-\nplatary surgery only in this dedicated fclty. Ambul\nory surgery wis defined as a “stme day of 23-hour ty\nlective procedure” ‘Scheduled outpatient procedure\nupgraded to inpatlent status due to intropertive events\nvere included inthe study sample since unplanned in\noperative events have no effect on the Inia pre\nspeatve testing decisions. In addition, we excluded\nprocedures that used only local anesthesia oF com\nous sedation without an aneithesologist or mid\nevel anesthesia provider yielding fnal cohort\n$111 patienss,", "Background", "Methods", "", "Participants" ]

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[ "rontoparietal lobe was hyperactive during set-shifting\naks tn AN patients.", "Cognitive inflexibility, mental rigidity, and difficulty\nwth decision making processes ate probably al involved\nthe etiopathogenesis and maintenance of AN [10].\n\nAlthough it could be speculated that a correlation\npte cognitive inplsment and malnutrition in AN i\npossible, recent evidence suggest that neuropeycholog\n\na performance is untelated to Body Mass Index (BMI\nbr starvation [3.1]. Therefore, farther research is war\nanted to determine what factors contribute to cognitive\nfexiblity impairment in AN. Two recent meta-analyses\n5.12], regarding neuropschologeal performance in AN,\nported that prior etdies were liited by all sample\n2es and not controling for confounding factors (6.\n\nJemographic and clinial characterises). To date, i\npatents with ED there iso information regarding cog\nve esbility sp verbal ables. These sil are impor\nant in psychotherapy, the peimary therapeate approach\nssd'in tho tomionens al aie", "TRAE =e tieice. Saeninetiog «peak (eth) Wm\ned in this dy to obtain a verbal domain messire of\nrogntive rigidity. The HSCT te neuropeychologica\nest of executive function created by Burgess ad Sha\nice [13] and i isa useful instrument to assess Af AN\npatients can perform tasks using both a good and ex\nle strategy while exerting appropiate contol inhibi\nlon of thelr responses. Indeed It is 4 measure of\ncogltive flexibility, response ination, and response\nsuppression. In the existing Iteratre, the HSCT has\npen successfully use to evaluate these neuropycholo\neal factors in patients with Parkinson's Disease [14] i\nikren with Attention Deficit Hyperactivity Disorder\n15, recently inpatients with Unipolar Depression (16,\nand in IMIR studies on prefoatal activation in Bipla\nDisorder and Schizophrenia [171", "SEE Any 2 DOE ay We te 8) See Pence ee\ngarding cognitive flexibility and decision-making\npaiement in a cohort of AN-R patients, b) bette\nunderstand whether cognitive inflebilty pers i ver\n\npal tasks as measured on the HSCT, and e) examine\nwether dferences in neuropsychologcal test peor\nance ate associated wih years of education, BMI, dis\nase duration, and depression severly. We hypothesized\nhat cognitive lmpalrment would be confirmed ia AN-R\npatents using the HSCT, and tha differences in cog\nve inflexiilty between AN-R and healthy controls\nwould be independent of the above mentioned demo\n\nsraphic and clinical vartables.", "rype (AN-R) and 30 age-matched healthy controls (HC).\nThe AN-R patients were conseeutvely recruited from\nhe Eating Disorders Center ofthe University of Turin\nSan Giovanni Batista Hospital). OF the 30 patients 1\nvere partially hospitalised, 3 were hospitalised, and 17\nwere oulpitients. All participants provided written\nnormed consent according to the Ethical Commitee of\nhe Department of Neuroscleace ofthe Universit o\nroma", "ae Sample for tis study consisted of 60 participants,\nSO patina dinmsosedl otis Anemenls'Haicusen Mesictes", "Fettonts were inciuced in this study who met [he\ntrctured Clinical Intervie for DSM Disorders (SCID-\n) [18] diagnose criteria for Anorexia Newosa Restc\nuve type (AN-R) theoughout the peor year. The SCID\nwas administered by an experienced psychiatrist Incl\n\non ereria were a) no severe medical comorbidity (eg.\npilepsy oF dabetes)b) no deug dependence: and\nfemale gender, Patients were all Caucasian. Helly co\nrol (HC) participants were recruited from the Univer\n\nity of Turin, and were only included in the study\nhey were free of peychiatric and medical illnesses.", "ber sampler se Ready Eee apeceene athe a\npatients underwent individualized pharmacotherapy aad\npsychotherapy. Because of illness severity and now-\ncaponsiveness to treatment, a large part ofthe sample\nf= 12) had aleady recived previous teateat in ou\nED Program.", "Me decided not to include the AN Binge “urging sub-\nype (AN-BP) because iti known that AN-BP indivi\nIuals are diferent trom AN-R patients conceening\nseveral features that could affect neuropeychologit per\nformance, In detail personality characterises ~ mall\nmpulsivity- [2.19], obsessive tits [2021], prognosis\n2}, and se shifting [11] have been shown to be sigai\ncantly different between subgroups. Moreover, zecent\npcliminary neuroimaging data showed hoe AN-BP and\nAN-R individuals differ, particulary with regard o\necuiaioier Ea", "AAS ih teh ey ae enews CWee Cae ee\njerentiate these two subtypes on neuropsychoogca\nests, This could representa limitation for this study\nnd future esearch thus ature investigation of ANC-BP\ntubtype ia needed.", "We sensened chamnctechtics of the eating (enter Miness tn\nthe AN-R sample with the Eating Disorder lnventory-2\nEDL) [24] and Body Mass Index (BMI, and depression\nevery was evaliated with the Beck Deprestion laventiry\n(BDI [25]. Overall functioning was evaluated with the\nGlobal Assessment of Functioning scale (GAF) [26]", "We used a comprehensive neuropsychological battery\ncomprised of the Wisconsin Card Soeting Test (WCST),", "Methods", "Patients and Procedures", "", "Neuropsychiatric Assessment", "Neuropsychological Assessment" ]

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[ "paticlegicelty slewent lle events hed not been pleted\nip by routine nial messes Hewove, in ip\nfant niarty (ION) of CD cases no severe if event\nsos Shaneiiaiin:", "ius stucly is limited by several potential biases. First,\ncD patent were sera frau epeibit servic\nsnare thereto Hkly tobe lately severe alo\nrove shown le etl resvery, hereby ling ge\nzalabliy. Second, interviewers were winded t\nssecontol tty, although the cnsensn pel\nngevents were: Furthermore, healthy ont dept\nsora to minimize tis ad slightly sorter Hie\npoean 1.96 yen compared to 242 yea) betwee\ndy pid start dates and interview dates leading\npotential recall bis, A sitalar reall bias could\ntur duet ey deft in CD which me elative\ncea epee are fo which hese ei\nJence of actual deft (Broen eal 2013), alto\nermiving such recall ines world only incre th\nliferences we found. Detecting abuse with the LEDS\nsll salt in underettina fog. unig\ndice such sitive infomation during fort\nace inkerviews) or overesimatons eg alse menor\n= confimaory evidence not obtained) although the\npte biases alo crur with ater detection met\nvs (one ct al. 2000),", "PERS 6 Oy St CSD CAREC eR Oe eae\nae poyehotie and endogenous subiypes and wen\noe the ave geographical ares aed snr in ogo\nx nd ey seetreronomic variables to the CD\ntc The hey conto might ave ben pes\nctly matched for all variable a evidences by the\nignfcanty higher mean 1Q in contol (102.5) con\npred to CD patients (100.3) which i Hkly to el\nom 4 bins mong Ge belt indvidls sep\nriations 1 fake parts the stay. Finally thes\nwas on neurological conte group ancl eleva ra\ni ile events have been fou in take (Hove\n950) and muiple seers (Grant fa. 1989 lb\nconsiderably lower sales than fund in CD in his\ntuady with sinlar methods (LEDS), It should ale be\note ates aointed with the onset r eran\npon of many other neurologic disorders, forex\nample migraine (Perot 2018) and cpp\nWassensrct 2014), a wel many’ othe non neu\ngia! doorders, for example myocar snarton\nWel et af. 2014) and ponciacia (Fitenter etal. 2083).", "En terms of speciicity of the results, although psych\nsrc conteols ere avaiable they were om a eat\ntudy so cannot be considered flly\"malched! like he\npathy conta and there i nt comparable dato\nQ and HADS scores, However these depression\nmes were inkervicwed wong the Pres Si\nScamination (Wing ta 1970), wth supplementary\nwestions to encble remarch disguoene crite", "Although our finding of elevated rates of stressors in\nhe year before onset of CD spots he poyhologic\nmodel it ofcourse doce not eblish aetiogial ee\nrane expecly sours highlights tha tas\nme sltvely etmanom contol In any given id\nrikal chance could therefore somata te presene\nnha strona, and evidently this would become mor\nily with nceasing He eee stressor a hn\nom onset However the apy escalating ates\nvere events we found CD, but nak cots, ith\neven proinly to sympa enact provide up\nort for chological velevanee", "Table 4. Rates of abuse in conversion disorder (CD), healthy controls (HC) and depression (DEP)", "<5 cen,", "", "", "linplications", "The psychulogical modet" ]

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[ "Nasopharyngeal carcinoma (NPC) is a malignant tumoe\nhat ass in the mucosal epithelium ofthe poste wal\nothe nasopharys [1 selina presentation epidem\n\nlogy, and Ihstopathology are diferent fom other sq\nns ell carcinomas ofthe head and nck [2]. NPC hs\nmarked ethne and geogrophl distribution, Speiealy,\nost common fom, Werld Healt Organization (WHO)\nye Is highly prevalent in southers China, Southeast\nAsa, Nowth Aca, and Greenland and is suongly assoc\nted wih the Epstin-Bare virus (EBV) [5-7]-In Moroco,\nNPC i the mast frequent tumor ofthe ead and neck\nelon accounting for 7—12% ofall ances in men [8 9\naterestngly, NPC has also been reported to be the ros\ncommon neoplaa of the nasopharynx and. cespcairy\nrac in cidren in Morocco and Tunisla accounting fo\n5-20 % of childhood malignancies [10 1, 9], This even\nhigher than ts inedence inthe high endemic NDC aes\nChina, where ie 01% in cildren (12,13). Dillerence\nNPC incidence ae also reported in the same gogeaple.\n\ncal locations between members f diferent edhale group\n1, 15]. Cerain detary habs such as consumption of\nsled sh and preserved food containing volatile mitrss\n\nines are als Feported to ply some cole inthe ely\nDENDC [16-18] Regardless of inesdence and geographieal\nlisubuton, is development has been attabuted to an\nteraction of multiple fete: environment including\nEBV infection and genetic factors [1, 20), Chromosotal\nAbnormal and abetant promoter hypermethyation\nhow a snaar pattern in diferent geographies regions\ncarding to one study so far, supporting a common ca\ndecals yathamey tn S00: ieap cs ck vagion AT", "eee ey ee eee Clagnosed’ In advanced\nages when treatment resus ate neaisicory This\nargly due tothe non-speic local symptoms [3 22-24)\nDisgnosis of NPC at stages r Is aso ith high\nural fate (om average 95), whereas the sural rat\njust above 50% when diagno i made late at stages I\nor I [25]. Because of 4 higher care rate for eae sage\nNPC, the concep of sereeing for the disease has an\ntuilve appeal. Further development of therapies is ne\ncesar but not slcent to impove the suv of NPC\npatents [26 The development of rlable, noninvasive,\nnd costeffecive eaiy-dtetion methods for NPC & 3\nhgh peoety. Applicaton of tumor markers thus provides\nrelevant approach to achieve eal detection of NPC.\nThe rapid acquisition of fly sequenced cancer genome\nwl be one poweral tol to ently biomarker candidates\nior eels doreciloc, uh, wal cuacer ecrasaine OA", "sepia mien aaenebringeranieana nina pemaneaer tere aae\nay dive epigenetic changes in normal epithelal cells\na promote tumorigenels [31]. But genetic alterations\neluding, deoxyribonucleic acd (DNA) metiyation of\nsjelin-dependent Kinase inhibitor 2 (P16) and RASSFLA\nJoc Rave been reported o acct pealignantnasophe\nyal epthelam even peor to EBV infection (32), Aber\nant methylation of tumor suppresoe genes (TSG),\n\nP16, sa fequent event NPC [3], DNA methylation also\nlays an important ele the maintenance a specie EBV\nsteny program in the NPC call [34,31 35, Aberrant\nmethylation of both ved and cellar genes ay thus be\nvalved inthe tansrmaton and progression of axophe\n\nyngeal epithelial cls ito malignant ones [36-8], Screen\n\nng for DNA hypermethylated msker gene, eg, TSG,\npasa great potential t be wae as an ay for etly detec\njon of NPC [39], Moreover, the EBV hast epigenetic inter\nay andthe reversible nature of epgenctic mechanism of\ngene egulation in NPC make ach nes interesting ali\nhe context-af NPC therapy and. prevention [40-42\nRecent was demonstrated that gastie carcinoma a8\nsated with EBV i strongly hypermethylated (a a whole\numoe subgroup camped to EBV negative gsi crc\n\naay", "Ri has hoon suggested thet concer con be initiotedl by\nspigenetic change before any mutations take place. This\npigenetic progenitor hypathesis is supported by expee\nmental dats on, eq. colon cancer [28) Ths mabes ep\nSuMae auntoe Hagel Sckeceotie et amy Oaguacls os", "Several techniques for analyzing ON methyiation status\npave ben developed, each one wih advantages and mt\njons. As an example, methylation specie PCR (MSP)\nlows detection of one methylated gene copy among 100\nuamtylated copes 16] but can only be applied to one\njena a a tne, For high-throughput methylation studi,\nstate-of heart equipment and quaiied bsinformatics ar\neuted. Until now, this makes such teniques unable\nthe clinallvel [4]. De to this, we previously deve\npped a simple and rapid PCRbased assy designated\nmultiplex methylation specie PCR (MSP) which could\ntet the methylation satus of multiple markers in\ncis nection saencueweete", "iNest apfhed 2 Sees Sy epee aS Mee\nNPC risk than China like Morocen, Noe Alta (medium\nis) Ms performance deerssed, and this, we teed\nody the aay to obtain good speci and sens\nfor tumors in auch area Tht modified MMSD asst\neludes, as before, prealence of the EBV nuclear antigen\n1 (EBNAL) (nt methylated), portant for distinguishing\npatween EBY. pote and EBV negative subtypes of NPC\nnon-cancerous conta samples. The expression level\nEBV encoded latent membrane peotein-1 (LMP!), which\nan EBV oncoprotein, expressed in approiately 65% o\nEBV: positive NPC patients and was elated by promote\nethation [9]. Outcome of LMPL i the MMSP panel\nwould rellect LMPexpesion status. In addon w the\nEBV genes, tee TSGs namely integrin, alpha 9 UTA)\ntas asocation (RAIGDS/AF-6) domain amily member 1\nRASSFIA); and PI6 were included after screening the", "Background" ]

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[ 1, 1, 1, 1, 1, 1, 2 ]

[ "eeend, Ae Oe nD. Pee areas events nee Ie\nued sania (1 = 3 paints) and gastroenteris (2 = 1)\nthe add-on itium group and mania (n= 6), agresion\nr= 1, sty = 1), and no therapeu response (r=\n1 in the add-on plcebo group. The SAES of emergent\nania led to study discontinuation in two palente in\nfhe add-on lithium and sx patients inthe add-on placebo\nan", "ANCRRECee 28. Cte. ateniewy tewied te EE>. Were\n1689 in the add-on lth and 6% inthe add-on pla\ncho group ind tem in 156% and 49% of patients,\nspectively All hee TEAFs were mid to moderate i i\nesl. Two TEAFs (wemor and dystonia) resed in ty\nJscontinution in the add-on placebo group. The majo\nnf patents showed eiher Improvement or no change i\nEPS severity davig the study assessed by SAS, AIMS, and\nBARS scores For example, SAS score Was improved i\n116% and 2% of the addhon Utkin and plcebo ad\ngroups, respectvaly, unchanged in 67.1% and 7548 and\nworsened in 156% and 938%, espectively at day 43. No\npatents nated anticholinergic medion fr new-ose\nos.", "Po. As patently Beaten 02 canny Were error\nherkir Wai sede CedeabieDeicias Semis aioe Seal", "eto\nsecclinn laboarved coos data, ITT set,", "re eee Sennen Tere Deeps Se ee ee\nsrimary and sacomaiary efficacy mensures @TT et)", "", "I\nhe ~" ]

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[ "ine equating process for Bart 2 was similar except that\nhe base form was 2009/3, and the pass mark wt se\nie", "POO aes, Mere. Seng Was. tetrodecee then wae\nsuggestion that alkbough the pas rate seemed to have\nmained constant in UK. graduates (the eeferenc\nroup) the pas ate a non-UK graduates had increased\nfeature noticed fsty in the Part 1 examination and\nhen also noticed inthe Part 2 examination when sal\nical equating was intzoduced It tok Several yeas foe\nJo become clear whether the phenomena were ral and\nJong-lved, and during that time reaearch was begun t\nretin aft aouued bo be Sejament chereen", "formed’ the relerence group, ane other candidates (non-\nUK). The latter i inevitably a heterogenous geoup wit\nome candidates being on UK taining schemes, some\nworking in the UK and not on training schemes, and\nany others working in other countries and who Bave\nnever worked in the UK. Relatively few buckground dat\nre avalabl for dese candidates, beyond age sx, and\nlate and place of primary medical qualificatien,", "ie Erhinacy Sate Soe ie RnR yeee Sp. CMe APAUME OS SAE,\ndates taking MRCD(UK) Pat 1 fom 2008/2 2013,\njot Past 2 from 2002/2 to 2013/1, and in addition\nPACES data were avalble fom 2001/1 to 2013/1, Not\ndata wore used forall anayeen. Results are generally\nmpresed as pass of fall with more detalled analyse\nsing individual eek, typically expres at marks ce\nstv to the pass mark. Detaled data om individual tes\nsnswered covet were aso used for dierent item\nfunctioning (DIF) analyses. Candidates were divided int\nthose who had qualified at UK medical schools, and who", "Commmatiqnal Hanisicel anatyess were coctied ou: muing\nSPSS v2, and eoutine IRT analyse, including satis\nsquat. were carted out using Whats, Dire\ntem analyses were carried out using Bulog: MG v3.0.", "Ethical permission was not required for this study as it in-\nvolved the routine analysis of educational test da, and\npence was exempted from teguing permssion unde\necmplion eof the UCL Research Ethics Commit\nhttp, /fethice grad.uclacul/exemptions php),", "SRE ees eee aes ot es et ane\nigure 2 shows pass fates fr MRCD(UK) Pat 2 In each\nigure the pass fates (vera) are shows for candidates\nreach dit (horizon), divided as UK fst ie takers,\n2 UK candidates, non-UK Test te takers, and all non\nUK candidates, The eed box indicates the dit fr which\natstical equating was used, and the green vera\nows indicate the diet used as the base form, and the\net for which re-equating occurred. There are thre\nets per year and for convenience the vertical blu\nrows indicate the third diet ofeach yar. Two separate\nsfiects of statistical equating seemed ts be apparent.", "For Part 1 there is a strong suggestion, at least visibly,\nat although the average pas rate for UK graduates re\nmains sable, the pas fate for non-UK graduates jus\ner the introduction of stats equating and remain\nhigher foe the nea four yeas. ina effects ate also ap\nparent for Part 2 but age not to be as large. Table 1\nrompares the averaged pass ates for the various groups\npe and postequating. Changes for the UK groups ar\nral nal cases, However, for non-UK groupe ii clea\nhat the pass rate as gone up by about 170s for Dat\nand somewhat less, by about 1.25 for art 2.A simple\nMana-Whitney U-test on the 30 Part 1 pass cates (0\nhe 25 Part 2 pass rats), comparing those belore and\nfer statistical equating was intoduced, shows highly\nignlfeant increase in pass fates for non-UK takes o\npart 2 witha signet effect alo for Noa-UK Ist ne\ncoer", "a a ee a a\nwere chon for showing appropriate levee of\n‘fet and iem-toal corelations and hence\nperforming well They should slo be representative\n(ofthe examination ata whole, covering al ofthe\nvatious domains inthe Blueprint.\n\n5. Candidate scores ae escultd forthe canddates i\nthe anchored easton. Since thete ae onthe\nsame scale a inthe concurrent cation, those\nscoring 521 or more pss the exam and others i,\n“That pss mark oa the common scale can be\n‘converted into a simple pereenage of tems correct,\ndnd that percentage used to score all candidates,\nTaking dhe examination, incding those who are nat\nUK fst tine takers\n\ns Atte next dit, which was 2009/1 the process\nrepeats, with an anchoved eabraton based oa\nanchor Kms which had previously been used,\n‘stimaton of dices foe peevieusly unused tems\nfd the addon of thelr dificult othe ban,\n‘aleulation ofa perentage pas mark based on the\n‘equated pss mask of 321, andthe cleulationof|\nps orf forall endidats taking the examination\n‘That process then repeats for each new dit of the", "Different pass rates in UK graduates and non-UK graduates", "Method", "Statistical methods", "Ethics", "", "increased pass rate of non-UK candidates" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 3, 2, 2, 2, 2, 2, 2 ]

[ "Se ee ee\naration following trauma, research ftom cont regions shows tat almost everyone develops posta\nmae sess divrder (PTSD) i teaumaexponre reaches exzeme lve. Theor evaluating the let\nmule trauma exposure of union importance a tds ivesiatn tk factors for PISD. Ye\nssatal loan Gaon donated bu: auateate Taomr fits Innnecinet qusiasmmental tame Sachor ean be bait eeueiirid,", "nf 227 Ugandan rebel war survivors. Trauma exposure Was modeled a the numberof traumatic even pe", "om the umber of diferent traumatic event types experienced, incusion of event feguencies igh\naonsoved tha prodiction of current PTSD.", "onsumingssesmeat ad ads to the Best prediction of ete PTSD, we reommend ths measure for\nseeuhi on Pr) llslone", "", "I: | EDGUSTEIRY COURTFIES, THE NCRRIE PrEVANCAEE OF posts\n‘uaumatie suess disorder PTSD) was estimated t\nhe below 10 although the jority fiddle\nported at east one waumatc expenene (Kesler, Soames,\nBromel, Hughes & Neon, 1998). These findings su\nved high variably inthe psychological response t\nsua and raised the interest i individual PTSD es\nators (DiGangt et al, 2013) including genetic suscep\nity factors (Cornel, Nugent, Amtadter, & Koen,\n>010).", "symptom severity in a dose-dependent mannet, a phe\nnomenon termed buling Hock effect (Kelas eta\n2010; Molica, Melons, Poole, & To, 1998, Newgehaue\nnt al., 2009: Neuner et al., 2004).", "Sear cesponse varniion folowing single irauma is\nhgh, PTSD prevalence approaches, 100% at extreme\neves of tauna exposure (Kolasa, El, Kol, Onyut\n& Elbert, 2010: Neuner et al., 2004). Cumulative expo.", "a ee\nactors need 10 consider the fet of cumulative tea\natc exprinces To obtain valid conclusions. For i\nance, iis highly recommended to include (aus\nxposute ib gent studies o PTSD risk and to mod\ngene envionment interactions (Cornelis etal, 2010\nWilker & Kolssa, 2013). However, in comtast 10 th\nsgreement on the necessity to include trauma exposure i\niological esearch on PTSD, relatively litte research has", "", "RCS NNR Te Or MANNA Puralo, JONES HOpPKInG HOOD SCHANN Of PUP, LA.", "nan be found at wwwejpt.net", "A oltre fi rib ken erllpary er Peel Ptah ella\nVio ntematona.Alenabach, Garmany. “Ciical Payehology, Unwery of Konstanz, Konan\nSoran Ee bean A Monin Gaenes", "How to quantify exposure to traumatic stress? Reliability\nand predictive validity of measures for cumulative\ntrauma exposure in a post-conflict population", "Sarah Wilker \"|, Anett Preitfer”, Stephan Kotessa', Daniela Kosiowski',\nThomas Elbert? and Iris-Tatjana Kolassa’" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1 ]

[ "pmbryas, whereas H-Positive superior cervical ganglia (8CG) and the\note (i A). Tose whether ie impreon War al,\nnothet ie deny of te renal dopanierge pojcton a\nfr /~ embryo ain Ap © > teat Besa te rot\nfidence, te length of developing sal projection was oat st", "Quantification camed out on a very large Sumber of embryos (Apri\n+t embryen a= 20, pd ~/~ emo n = 2) resale» igh\nenn glen ned wh A\npeng eso n/p bt te\nenghos (SCG) wich contin THerening sens ha et\nSoa A/a pe 0, eae\neth Sg eth PR ps st", "eet eee ot ee ee\nrep in dng iin et ca, AP\ncy aid min Spee mo os\ni il avr ont oh ee\nsfc evblshed at E12 and EL, CONF enhanced ston gro\nerst tl 108), These dene been GDNF and AP\nfe inlaw he abered nthe developing peril nev\nru (PS) betwen cane sereonie facts an TNISF mem\nWes nevi nd sf GNF ly pes\nlope [vin 2) member of th TNS ht af he ro\npenta windows (vse al 200, Kaen aby 2013\nenn tly 2036, Oks 208) wih te exepton\nRANKL which as oer a extended pid of postal evelopment\nteres ta 0). While APRIL ar been shown teshne 360,\ndal nero (Oerio 30 wae mt mented bet\nee", "Socked by sbt:BCMA (ova 701 ABRIL ral ang\ncored pete, bt proceed the Gg spurte by 3\nver cay to genres Hlopaly nite scted pron\npes reset 20) ease erred APA can fea\nredness he wen mi\nteat eth ad tanker nee", "", "sion santa to spear oatagl oF stioned meade Gece\nTse inde heer meee the CONF tay ear\nHanger eal, 1098), emi (lsh el, 1996) and peep\nbod ca. 1980, VEGF protein nen ea 201, POG\net 1980), PACAP (aes), members 9 1\nian, nding TOP 1,2 and selene. 1590),\nregina eta 98S) and DFAS (Sela a 200), FOF\nOch a, 203) and te more een ntl ele ton\nEDN and MANE (odin ca Fo es, 200) My\natria, CONF, MANE, PDGF, FBO and PACAP (uncom sa\n\nle Vales 207), However, nebo abana mid\nrain dopamine eon phere as ben reported in ie at\nack nyo ths facts (ist 2) an whee 2 no\nete warn repre amie with sandal dln\ni theta (Fs 20), camped sa\nmulti mouse nese tad any shoo! dopa phe\nSee Oe", "aly» es i elgg oe nh\nfr\") mie compared wih dp + mee. The gneat de\nPh aN ki te Sa Al nd A/c, Th\nSgn satan nh esa Sew\njon wa sla np\" nd ped me ageing a\ni dow it eh a I ab pan\nsane of muraindopanisegie aetrns and wheter Apr\nsce develop a maar eect ith age Finally, brave epeneaion\nhe opin ner poecin 2 er of kia", "", "suigls fines esechoesha pean or ash bos POR", "", "", "" ]

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[ "Me ee on SSbeayed by Google Scholar in 30 steps\nXf 20 references each. This, behavior of Googe\nScholar outdated in a world where the Natio\nLibary of Medicine allows the complete downoad a\nVea ecole peneen", "pene the epee oe ee,\nWichout a history function and without convenient\nSearch expression builder might be tleabe fo\n‘power use’ who ate aecstored to working wit a\nteat editor in combination with a ing search\n‘expression enry Geld for dispatching. Far the ros\nInformation specs and scientists such a work bs\nrot acceptable and obstructs thei reality on\n‘subject matter. For the high takes documentation\ntasks of curent systematic reviews, at least a history\n‘cine eee", "ee ee ee ee\nshove are already implemented in Google Scholar and\nner Google praduts, but may be aricily rested\nbe nat fully functional in the Google Scholar search\nterface. Hence, it might be a question of plley and\negal Issues which hamper Google to provide a full\nfedged profesional scenic search tol, It was alway\n1 tain goal of Google to provide the implst search\nterface forthe average internet user. A high end scien\nite Hurature rtieval search interface i a. specialized\nfr researchers that might not Ot kn thi porto,\nOn the other hand, some content providers and pub\nhers might reset the use of tei reference informs\nson for Google Scholar users to a hind of “erppled\nscces\" wo protect thir own databases, scence porta\nind search interfices. Without a clear and trustworthy\nrommitment of Googe, Google Scholar will valve\nany a8 tool witha very limited scape of use. In i\nrutent state Google Schaar should nat be employed\nlone in structured sclentie work which alway celle\na ae", "Nithough Google Scholar was quickly adopted by the\ncienie community forts obvious ments and its easy\nser interlace [54], should be propagated with eae fo\nlimited application seope. The centile community\nspecilly inthe biomedical domain, has a high demand\nfo ey to use and relible search interfaces. chi wel\nstifled quirement is met by premature and overly op\numistie expectations in new tecnology, users may tend\n0 leave wal approved methodology. Hence, as educs\nor of sclentiie methodalogy, we rast be careful on\npaw ta connmunicate new technology to users. A goal of\naur research should be to indicate wetknesss of new\nechnology to thelr providers Providers can enhance\nir tals based on this information so that thelr prod\nuct consequently meets more extra for professional\nvoholesty week,", "This Sadly is Eeiied due to the emel camber of i\nduded Cachrane reviews fom fw medial dommtins and\nhe overall Limited sizeof the alternative gold standard\naul st of about 400 included references, The raul\ntis study were not intended tobe generalizable to al\nyes of erature search or all types of contents, We\nunderstand this study ab 4 case series which provides\nimited evidence for the Yypes of studies investigate\nsan", "Aa tated betore, maother important Eeitation of one\nstudy i that we did ot full optimize the applied Goo-\nle Scholar searches. We developed the searches based\nbt the original MEDLINE searches frm the Cochrane\neviews with the limitation ofthe Google Scholar search\ninterface. We only optimized the Search expressions fo\nvous errs in 4 short Merton eyle. Optimization of\nGoogle Scholar search expression lay outside the spe of\nis research. Therefore the reported results, especialy\non precision, must be read with eae in light of potenti\nnptimization, tis well possible, to enhance precision\na ies ih oe Ge,", "my the past, studies from a broad’ fel’ of medica’ ane\nfener scenic subjects were chosen to investigate the\nperformance of Google Scholar. However, even a large\nmumber of studies and ceviews from a variety of\nJomains should be retrospectively investigated for the\nperformance of Google Scholar under “real world\ncs contend", "Google Scholar search expression optimization is an-\nther area for fture research, Given the Limited capabi-\nles and. the nontransparent ranking algorithms,\nould be empirically vestigated how search expres\nons can be optimized for precision and real It might\npe possible, that conventional search expression gener\nton established for other scientiledatabuses could be\nsaiiid tor Goss Shaler", "2 Ee ee 2 ee\nnthe retrieval tool, comparative prospective studies ae\npacestary. Only with this design it becomes posible to\ncompare the systematic search approach of traditional\niteatue retteval with new methods, especially Gaogl\nScholar, with minimized biases, However, depending on\nformation specialty in ts implementation, cis type\nof research is methodologically diel: independent\ncams of information specialists search forthe same #e\narch questions with diferent tools and are eventually\ncompared on thee eetseval performance. With this ap\nproach, confounding parameters due to unbalanced\nrmpeencis inthe teas can only hardy be contol\nHowever, with complex (coss-over) designs, the let\nst ach belie rote cnc ened Be tonto", "Limitations of the study", "Further research" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2 ]

[ "a oe eee See ee\nile In this context, led but sigaiieant alterations\nthe carbon fx dstibuton over the central metabo\nsm have been recently reported [21-24]. Also, amino\nsid supplementation ofthe growth medium has been\nhows to partly unbueden cellar metablisn daring\ncombinant proteln production in yeast (23.25.27) ln\nresting, such sts iP. pastors have provided novel\nidence thatthe adaptation of the central metabolism\no combinant protein production can not only be ex\nplsined by an increased drain of precursors for protein\nathe [23]. Indeed, amino acids are not only impor\nIn precursors for protein syathess but als participate\nthe regulation of jr eneabole pathways, Glutamic\nund Aspartic aid for instance, are components of the\nspartate/malate redox shutle [28] and their concent\nions may inde impact on the rate of oxidation of\nSosiete MATE", "Me Dave previously reported’ the Denelicia’ impact of\nnypanta condions on recombinant pratsn production\n8 P.pastori 29}. The pysaogial bases ofthis benef\nial effoct were further investigated ina recent mulllevl\ndy including transciptome, proteome and eetabolc\nux analyses [0]. These studs allowed to gather infor\nation on the bologialproceaes involved tn the adap\nation to hypoxia and thelr relation with exteacllua\ncombinant protein production in P pastoris. However\nhe potential eflet of oxygen avalbilty anda recon\npnant protein production on the itacllulr metab\njevee(partculil of the amino ald precursors used fo\nsroteln synthesis) remains to be elucidated.", "non producing) strain () and further combiner wn\nhe metalic Manes related fo protein synthesis and lo\npal transcriptome dataset from ou previous study per\narmed with dhe same strains and analogous eulthation\ncndtlns (30), Overall hs study aimed at understanding\nther dhe behvour of the variations ln ntracell ating\nsci levels a a reall ofthe diferent oxygenation candi\nions employed, aswell a gaining further insight in the\npotential interactions between energy metabolism and\nrina acd neta and, how auch iterations ay be\n= oka lr Leteaslagiens vials ection pelea", "Te investignts the potential impact of foreign protein\nexpression and serelion on amino acid metabo, the\nee intracellular amino acids pools were alyzed in car\npon lied ehemasttcultvations ata xed growth rat\nsnd diferent oxygenation conditions, using 4 recombi\nnant P. pastoris strain Sereting an antibody Fab Tag\nment (E), The results are compared to the reference", "ee re ae a ee\nyeas and, in artical, pastors, has been rece\nsuggested to impact the central metabolism even at el\ney low expession lees, Le where increased eee\n(atin sed) demands for recombinant poten produc\njon maybe nelle [10.23.24] Intgaon of wanserp\nemie, fuxomie and melabolomie dita of recombinant\nlls under diferent envisonmental conditions nay bel\n0 understand the metabolcadapations af the ells ce\nval metabolism to protein production under diferent\n-vronmental condtlons, partly in relation to amino\nsid metabo. In thi study, intracellular amino acid\npols of «recombinant P. pairs strain expresing an\nsnubody Fab fragment under the contol of const\nive PGAP promoter were measured dusing growth i\nicone ited cherostt cultures under diferent oxygen\nvallblty conditions, The macroeopic growth parr\ners for bith the contd and Fab-poduting P. pastor\nruins during growth at thive diferent oxygenation\njevele ae given in Table 1, Coherent with previous studi\n3031, the adaptation from norm fully aerobic) to\nnypont: conditions lead to shift frm fll eepratoy\n1 veqpiro-fermentative metabolism, as well as increased", "ale 1 Summary of macromolecular\nar culture parameters", "hn pay Comin at Gen eta a wich Hn ge BEM yl i", "Remained ype Raman Oita ypn", "Results and discussions", "Growl and’ recombinant protein secretion in\ncomiieeth pase" ]

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[ 1, 1, 1, 1, 1, 1, 1, 4, 2, 2 ]

[ "phe ost Chllcult aspect of aggregating cata from multiple sources, aside trom the\nmethodological variation in its creation, i the valaton in degree of description and\nrms used to describe the data. Data ute agreements can be used to declare a tin\nmum standard for upload and inclusion.", "‘Dota wes aguementy com be used to sees the quelilicetions of hath dein depositor\nund data user. Mees such as quality of dala against standardized metrics such a\nphantoms, for example or other quantitative measures can qully depotitors. Uses of\nhe data may aso need to be qualified expeclly i there ae rel costs astacated with\nllvering the dit. Can the user accommodate the volume of data? Have they seedy\necuested the sane data in the recent past? Are they adhering tothe rules ofthe dat\nuse agreement in the pst uch providing usage updates, credting the dita source o\naeaving iniiaiahdp cans?", "Data Use Agreements should consider the following;", "ae et ee ee ee ee eee ee ee\nsy) applicant qualifications are met, some type of appleation process may be war\nanted. Without placing undue burden oa the applicant, descriptions of specie re\nearch hypatheses and raionale for why the requested dataset is sulable along with\nseulitic plas micist'bs indocmaion", "‘Perception of fines ancl openness ane Important, Therefore, an independent access\ncontrol adiinistratr (atthe archivist else there maybe the perception of too much\ncontol concentrated by one entity) should review the request, evaluating the rede\nils ofthe requestor andthe siete merit ofthe propoted project as spud i\nhe data use policy. In most eases dealing with human subject data, the sequesor wil\npovide ll elevant information including) Copy of approved IRB oF Crtietion of\nExemption from IRB Review (if applicable), i). Completed and signed of Data Use", "OF RO Ce PRCT HARE Aendt CEacloreS a the aan\n2) Establish who i permuted to use or recive the data\n) Establish rules and requirments fr acknowledgement ofthe data sour, esting\n‘ofthe project, funder and others as required.\n) Ensure that the recipient or investigator we\n4. Not use o further diclowe the information other than as permitted inthe\nagreement or as eequed by lave\n1 Use appropriate sueguads to prevent use or disclosure ofthe information ater\n‘han as provided inthe agreement\nReport tothe archive administrators any unpeemited uses or disclosures;\n4. Ensure that anyone to whom she provides the data (allowable) agrees to the\nsame resections and conditions with respect to the information:\nNot atempt to deny the information oe contact the individuals kom whom\nhe data was collected.\n) Agee to provide study results atthe condhsion of their investigations (i equ)\n5) Investigators depositing data may ned to:\n4. Poses val IRB approval or Certification of Exemption fon IRB Review for\nprospective studies [47]\nb. Provide a copy of thelr Standard Operating Procedures document." ]

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[ 1, 1, 1, 1, 1, 3 ]

[ "pinuons on these videos Tiny. the social media website\nTumble which allows users to aggregate content accord\n\nng 10 tops (Lagging), was also reviewed for mentions\nof the word “bli”, This earch resulted in an tea\n‘ool of approximately 200 statements about bulimia,", "es es wee eee be ee ee\nnumberof items [St], conducted by the fest author\nhrough «procest of discussion with the second and\nied authors This involved organising items together\npase om thee salar subject mater, and resulted in sik\nairy coherent themes, cach comprising 20-30 state\nments, These themes were: bulimia as a problem, bu\nja a8 a solution, bulimia as choice, bulimia as\nperson, bulimia as normative, and bulimia as marina\nsed. Statements were then refined within each of thes\nhemes ths involved eliminating items that were repel\nsous, breaking up double are sems, and editing and\newording statements to prove thle readalty [S1,In\nvie of this al statements used the tr ulin\nhe han uli nervosa the teri wore, and a\nshir ainiooe tllaical ood leew ridelp Mecmes bem,", "ihe statement refining process resulted in a Q set of\n4 tems, which was plted with volunteers using the\nweb-based software Q-Assesior [60]. In response\nheir feedback am the tems and the Q sorting task, this\ntem pool was further shortened and refined to fal Q\naura sient", "mn methodology, recruitment of participants is @ stra-\ngic, rather than random, process [51] Patepants i\nhe tudy were recruited through two channel to\nmaximize the possbilty that a variety of perspectives\nould be expressed [46]. The fist group comprised 71\ndividual (39 women, 9 men, My = 22, SD = 6, fr\nher three did not provide demogeaphic deta), who\nented as having i least a general nawledge of bu\nna they were recruited though undergraduate psych\nlogy courses. It standard practice in Q methodology\n2 include individuals inthe P set whose viewpoats at\nparticular sigieance tothe reiearch focus (51). The\nst group ofthis sample fll this bl a5 ty shewed\nards younger wotnen, the dermographic in which et\nng disorders are most cornmon [34 further, as pepe\nlogy students, these individuals are assumed to have\nomne knowledge and interest in mental health To Gur\nher sii this ecommendation, the sscnd group of\nparticipants consisted of ix women who reported\naging ls bulimic behaviors (My. = 20, SD = 3). They\nwere reeruted through advertising on socal media and\nrough plat mater in public sites on university cn\ncor ene camen Genoen", "participants aid’ not provide cemograpluc details, some-\nhing that may have been due to technical dificult\nssocated with online dala collection, human eeeo\ne. missing a question oF closing the window eat),\norto a resistance to providing any personal or poten\nlly Mentifying information, While this stmple size\night be considered sal for conventional factor ans\nys, the nate ofthe tatstal technique in Q method\nslog, where the analysis 6 inverted, makes this sample\nprecy adequate (45) Indeed, the ele of unum offered\nfor use in Q methodology stds [29] indicates tata pr\nicipant pool of between 40 and 60 i stisctry for Q\nsass. The majority of ini n theD set indicated\nhe cultural group with which they identified as Anglo\nAustralian (528), followed by European (14%) and\nMiddle-eastern (13%).", "The Gnal F eet of 77 participants ranged i age fence\n17 to 50 (65 women, 9 men, M.,, = 22° SD = 6) Three", "Harticipants completed’ the 02 sorting task online, using\nthe website Q-Assessor [60).On the introduction page\nhey were asked to rank a Set of 42 statements fom\nhose they most agreed (+4) with to those they most dis\ngreed (4) with, based on how well they represented\nheir own understanding and thoughts about bli\nThe software directed participants trough thee stages\nof srting. In the est cach participant organised the\nstatements into thee categories those they aged wit,\nhose they disagreed with, and those they were nut\nout. At the second stage a fixed quasi-noemal ditib\nson (Figure 1) was introduced. This i standard tol in\nQ sorting the forced distutionsinplis later sta\nical procedures without impacting the fctrs that a\nproduced [6], while the quasi-normal shape reflect\nhat pstlpants wll el comparatively strongly about\nmuted number of items [51 Parucpants were fst\nshed to sort the poles (+4 and ~ they were able to\nSick through the statements, fat in the “age”, and\nhen “dares, category, to select and “sot” the two\nhey fel most strongly about. ln the third tage, pat\npants were fee to rank the mainder ofthe statement\nno the distbution, moving them around and reviewing\nhie placement up until they selected “submit Follow\nng the sorting tak, patcpants were asked a sre of\naperresponse quetions, These allowed partcipants to\nlabora how they found the ask and why thy sorted\nhe statements in the way Uy did (patil the poles)\nThere were albo a number of questions asking participants\nout their own understanding of bulimia, thei level of\npersonal involvement with the topic and how Uy care\nty aut of mak Lneulodes atone taeda", "Pachor enelyets is 9 common statistical method He classi\nfing variables; in Q methodology these variables are", "Recruitment and participants — the P set", "Procedure — Q sorting", "Q analysis and factor interpretation" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2 ]

[ "ceveral PEKies Sane Seeperd Ue Space of VN, ot\npid abundance using BBS data, Fujisaki etal. [24], fo\nexample, used change point analysis to detect abrupt\npopulation changes in bird populations and used the\nlecline of counts of American Crows in Maryland and\nVirginia in the wake of WNV emergence ss a ca\ndy. While the resulting change point estimates ace\n\nately reflect the time when WNV emerged in thes\ntates, the method does not lend itself to impact quant\natlon, Koenig ta. [25] found a significant decline in\ncord species between 2004 and 2005, concurrent wit\nwidesptead transmission in California,", "btained Dy two other methods, incluaing one similar\n‘0 the method used by LaDeau et al [26],", "LaDenn of al, [26] weed om extrapolation method t\nestimate the impact of WNV on bieds. They fit over\nlispersed Poisson models to 26 yeas of BBS count\nJt, adjusting for observer effects and macro-climate\njagcal factors. Based on the resulting parameter est\nmates and covatate profiles after WNV emergence\nhey constructed hypothetial count esjectoies that\night have been observed inthe abuence of WNV and\nrould be contrasted with observed counts. This\nmethod found a sigaiicant decline ln seven species of\npede and estimated a regional decline of American\nCrows by 45%, Wheeler et al. 27] used the same\nmethod, in combination with seroprevalence, dead bird\nsurveillance and suscepubilty data and found tha\npsides American Crows, populations of Howse Finches\n(Carpdacus mexicanas), Black-erowned Night Heros\nNeticonas nytioras), Western Seeub Jas (Aphelo\noma californica) and Yellow-billed Magpies (Plea nu\nall) were particularly affected by WNV. These\nstudies, however, did not take into account temporal\nutocorelation of bird counts that results from the\nfact that one year's population includes some of pre\nious yeas individuals ae well as previous year's of\nspring. An autoregressive model may therefore be\nmate appropeate forthe quanlifcalion of the impact\nDEWNV than a model that ignores ths dependence\nThe purpose of our study was to quantify the impact\nof WHY on six Novth American bin species using an\niutoregresive approach, Firat, we Bt autoregressive\nwwerdspersed Poisson models to annual bird counts\nhat included an indicator of WNV teananstion inte\nity. This type of model i intuitive, a8 It accounts fo\nhe underlying demographic process. Yeat-to-yea\nchanges in bird populations due to WNV ae likely\nmediated by WNV-asociated mortally. Using para\nmeter estimates obtained by fing such models, bu\nmitting terms associated with WNV transmission, we\nhen constructed counterfactual (hypothetical) count\nrajetories that can be compared to observed counts.\nThe difference between hypothetical and observed\ncounts is interpreted at impact due to WNV. We com-\nsee tha torciiing Supact estimates im satiuintes", "~ounts oF all Species varied considerably over the iv\nyears petind. American Crows appeared to decline\nwith the emergence of WNV in Illinois (IL), Lousiana\n(LA), Maryland (MD) and possibly Florida (FL (Figure\n1) Im Massachusetts (MA), both American Robins and\nHouse Sparrows appeared to decline once WNV\nemerged (Figuee 1). The count trajectories predicted by\nhe model ft the data overall quite well Most count\nwere contained in the 95% credible interval associated\nwith the coresponding model prediction (Additional\nile 1, Figures S156). Among the 54 models examined\nmote than half (29) explained atleast 50% ofthe total\ncount varanee (Table I) In FL, MA, MD and Minne\n\nota (MN), 25% oF more ofthe variance in American\nCrow counts was explained by WNV. Similarly high\npoportons of the vatance in the abundance of Amet-\nran Robins was explained by WNV in California (CA),\nMA, MN and Tennessee (TN). Only in MN, a substan\nlal proportion of the variance in Blue Jy abundance\nmost a. thid-was due. to WNV. In IL, WNV\n.ceounted for two fifth of the variance in Mourning\nDoves (Table 1). The impact of WNV on bieds varied\npy species and state. (Figure 2). American Crows suf\n\nered a substantial negative impact due to WNV. Le\n95 credible intervals did not reach hove zero in si\nof the ten states (FL, IL, MA, MD, MN and TX). The\nmost deleterious effect was found in IL (58% 95% Cl:\nTet, 31M), where In 2010 less than alf ofthe bird\nhat would have been expected in absence of WNV\nweve counted. In MA (2003: -41%; “62%, -13%), MD\n2008: -47%;-68%, -18W) and MN (2010: 50% -67%,\n27%) and TN (2010: 33% 39%, 1%) the lnegest nega\n\nive impact was somewhat less deamati, but stil sub\n\nstantial. In most of these cases, with the possible\nception of TN, where American Crows appeared t\n-ontinue thelr decline in response to WNV, the negative\nimpact af WNV seemed to have stabilized in recent\nyears (not shown). No ater species was a consistently\nlected. American Robins sullered substantally in MA\n2010: 50%; -70%, -238), MD (2008: -23%, -41%, 2%)\nsad MN (2007: -32%, 49%, -138), but in CA thei\npopulations thived after WNV emergence (2010 51%\n13%, 100%). House Spacows were regionally affected\nwith 4 more than four ith decline sn MA (2008: 4%\n100%, -32%) and reduction by almost two thie i MN\n2010: -62%, “88%, 8%). Like Northern Cardinals and\nue Jays, Mourning Doves appeared mostly unalfectd\nput in IL their numbers more than doubled (2010\n1n6te $4%, 258%).", "Results and Discussion", "Model fit and impact estimates" ]

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[ 32279.102100855787, 4628.709827811719, 117037.21909048874, 134812.93205485865, 1233.6138951325702, 1305.0178509042307 ]

[ 1, 1, 1, 1, 2, 2 ]

[ "py Simmondsia chinensis (Jojoba) oil (35), Helianthus\nsams seed (Sunflower) ol (33), Butyrpermu park\nShea) butter (29), Cera alba (bees wan) (23), Prunus\numydals dle (almond) ol (23), Olen europaea (ave)\nnl (21), Alue barbacdensis gel (17), Glycine soja (soybean)", "ee Company WHE the Lowest Sequency. Macnlinctners\nof expensive products tend ta specify more natural sub-\ntances on tir ingredient Hes than ther competitors\nling products at low prices Xanthan gum was the nat\nvral substance most frequently listed (50 times) followed", "Table 3 The ten companies of the present study and their brand specific selection of natural substances:", "", "" ]

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[ 14763.202567545697, 14724.670834627002, 4604.631487269464, 5435.944992030272, 250685.58252378437 ]

[ 1, 1, 1, 1, 4 ]

[ "iy Seeman Pe catet Bincyen), Tide amrannhvody\ndepositions were negative atthe begining a the chal\nenige study,", "Mtogether Tour cetlac cisease patients belonging to the\nrderate gluten dove group discontinued the study due\n2 abdominal symptoms shorly alter the challenge was\nited (aller the, eight, ten and 23 days), and they\nwere excluded fram the final analyses. Celie serology\nmained negative in all The fist two drop-outs with\ntremely bee gluten challenges underwent the follow\nup endoscopy, and no small- bowel mucosal detectors\n\nee wes ere", "The remaining 31 patente compciend the Smal study\npopulation (Tables 2 snd 3) for whom the gluten chal\nfenge lasted a median of 84 days {range 29-103 days)", "1 ree eee oe he oe eee ee\nan", "SE ENS COS SS Nae RS Te OS pees on ee ee eee ee\ndepth rato (VRID), densities of CD3+ intraepithelial ymphocytes EL] and gastrointestinal symptoms in trate\ncaliac disensa pationts", "“humo:\n\\ ray Hasidic", "aad ee\nse dap.\n\nSpo ye on pe = gyn = Mt gn,\n\nPais asp then al ape up peta ES cena nNOS EL i wan yt", "ie men Pray wore\nnanan of ghcn ie de san ang yas,", "No Maan daily ghten Intake (g) Curation of gluten challenge (days) == Smalihowel opsy = Syrmptomet" ]

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[ 1, 1, 1, 1, 1, 1, 1, 4, 4 ]

[ "in beth dhe gtomerelll qacl cbaies im sections of the diabetic Midaey (Figuenc-t, -2). ln\nhe diabetic kidney sections, the signals af 0-GleNAcylated -actinin 4 were increased\nspecially in the podocytes ofthe glomerul (Figure 6-1D). The localizations of O-\nGleNAcylated actin, actin 4, and myosin shown by a situ PLA were almost the\nsams $a sind sissicvedl les ic comeenttanal teieniacehiniaclinulesd tude (Feces Ss", "sctinin 4 Electron meroscopc appearance of mcroidh ofthe woul Af) and mmmunoelecton®\nmerocopelnanenefrvnn 4 n mc) din the thes ren FC) of des 1\nCompan techon megaphone: a erate tan abet\ntreguld Ferns of rma an ate te\nri ain! m8 pa hey on ne md\nmeal of roel tases nt abet sey 0} Cray ore fal Ss\nrete paring actin n he mca fr rand Gen aoe ny ed be)\niw othe mas St ete 0 cre tart The\noe ga ee aang eae ee ae sens oe ee ens", "Wistar rat GK rat\"\nTE OW Os\nLie i ' a\n\nih My) He AN ya\n\neh fy a a eA ae f\n‘ Ve eK\n\neh a et) ; 4\n\n7 Dy dais 4 A\n\nNe | So ib eh teat\ni; | eee S\nWistar rat ra ._—<= a>." ]

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[ 24136.97273946693, 42611.076898416504, 151750.08449686243 ]

[ 1, 1, 5 ]

[ "inhibitors (Fig. 1). Modeling studies suggest that the y-fluorine atom in the core of\naminoelfonylbydoxaile sed reidues appear to influence the relative potenele via\npecie nhbitor-pepidase interactions, including short Muorine-hydeogen contact,\nwithin the enzyme’s subpockets (Behrends et al. 2015).", "NO study MMS aCeNIRY In. VINO in disease, racholabeled MNES Nanctioning a8 racio-\nracers have been syathesied and evaluated by means of SPECT and PET. Unfort\nnately, most ofthe radiolabeled MMPIe suffer fom insult metabole instability,\nast excretory elinination and inaulicient target binding. Charscterstealy, the fst\nood clearance and therefore insulficient bioavalabilty of radiolabeled MMPI\nsased on a very efficient hepatobiliary tracer elimination (Matusiak et al. 2013).", "Te latroduction of urine atom|s) Into organic molecules is Known to influence their\npharmacokinetics, binding afte and lpopliity (Hagan, 2008; Purser etal. 2008\nBegud and Banset-Depo, 2008; Yamasaki etal. 2008; Gils eta. 2015 Huchet et\n2015; Meanwell, 2018) Thus, inkage of an addtional furine-comtaining funciona\nyoup in remote position tothe zine binding moiety might contbute to moe ecient\nnding of the intr inthe active center ofthe enzyme (eltends et al. 2015). More\nett could enhance the metabolic tablty and might retard heptablary eiinain\nsulting in abit ofthe clearance towards ior seal elimination due to change i\nophilty In addition, a radolabeled y-uorinated -aminohydroxamic acd coul\npssly represent an effective radiotracer or imaging MMP-2 and -9 wih improved\npharmacokinetic properties and overall target binding afinitis. Hence, the ain of ths\nwork Is the synthesis of a y-Muornated MMD-2 and -9 Inhibitor based on\n-alfonylaminohydronatie aid with an addinalfurine-containingaubttuent alla\nog \"E-radilbelng and evaluation of ts potential for the application aa radiaracer to\nsage MMP activity tn vivo.", "nL SATE RAE we RC MONFENPo Tee Apes, oF Ee, Senne sere <a\nyade, purchased fora commercial sources and used without further purieation unless\ntherwise specified All sir and molsure-sensitive reactions were performed unde\nugon atmosphere. Sokents were pured and deed analog to Merature methods\nwhere necessary. The malting points (mp) ate uncoeected and were determined in ex\nnillary tubes on a Stuart Scientific SMPS capillary melting point apparatus. Column", "Faia Reh Some iee ote ae enue en een enrages\nshareon oh 1957. Scccrmfinn at al 2000, Bohweech ato. 2015)", "", "Methods", "General methods and chemistry" ]

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[ 1, 1, 1, 1, 1, 4, 2, 2 ]

[ "EE\nraegles for presenting a aysterate review. Two tl\nwere found that offered promising res but reported\ndy quality was United due to thi al samples and\nprtispants tat were dravm Gorn a convenience spl\nfisted wth the Cochrane Callboraton [1,15]. At\nsul, we found no studies tha rigaouely evahted the\nnp of diferent formas for systematic revs with nd", "Ne Geveloped’ two shortened’ systematic review lormats to\nhance thet use In cial dca eaking that cold be\nore 3s companion product to a fullength s)stematic\neven. The prtatypes were developed sing ira\nvce ncding a mapping execs, a erie evaluation,\ned cla content review which was follawed by fc\nrope and wat testing with lias [1618 In de\na asst thee shortened fora, an online randomized\ncontroled tal & planned 19 make comprsons to a ful\nJeng systema eiew where the purpose a the ul scale\naedocied controlled ral wil be to determine the pac\ntwo distinct shortened sistema reve formats con\npared with 2 traditional fallength presentation of a ss\n\neat revew on generalist physicians understanding of\nence andthe ability to apy to a patient ina lina\nscenario. The peimary outcome wil be the proportion o\nSnslans who appropriately aply the evidence fon each\nsystematic review format tothe paint in the clea sce\naro ae metsured by agreement with an expert pls rc\nonendaton, and the secondary outcome wil be the\npoportion of dinans who acciatly define the “linea\npot in” compared with Hat of an expert pand. Pot\ntudes are a inprtant precursor to false als and\nther evalatlons of interventions a they provide che op\n\nportunity to implement and test dhe context and cond\n\nsons of fill ndomized tal [9], The Medial Research\nCouncil (MC) framework provides a model to adres\nome of the inticices in developing and eraluating com\nlex interventions [20) The updated 2008 MRC famewosk\n21] lfers focused atenton to early phase pling and\nsessment of feasblty(2]-I entiies that re-sale\nvaluations canbe undermined by dificalies suchas ac\n\n~pabllty, compliance, andthe delivery a the Intervention\n21], The ploting sage peonides the opportunity to «st\nate rates of rcrultment and rteton and calcul ap\npopte sample ss [21] To prepare forthe full-scale\nval, we conducted plot study. The purpose ofthe pot\nstudy so tet methods and procedres in order to refine\nios pepeees Set hr loner econ oie", "Se\nFie Seaieine woo eas", "i SgeRe OE: ee NRE EY Were Un tetrcenne Uae\neaubly of (1) aseting partipant’ anawers and C2)\nsorution putiiousis ian tase mame A wit", "Phere is Ho Toemal guidance for the reporting of pilot studies\njo eandomized conrad als however Thabane and ca\nagus [19] provide \"Recommendations fr Reporting the\nsulle of Pee Studies” adopted from the CONSORT\nstatement [23] dat are followed for this study (Additional\nfe 1). Two aerate systematic review formats wer deve\napd focusing on taking talons sptematc reviews\nshorter in length wea the sme ve mating exe\nfal nfo fr cial decson- making. This proces\ndescribed in previous publiations [16-18]. Heel,\nprototypes for two formats ofa shortened systematic\neview were developed in collaboration with human\nactors engineer bused on principles of user-centered\nJesign and included a mapping exercise to Identify ab\ntacles described by ciiclans in using clinical ev\nJence in decision-making. «heute evaluation ofthe\nprototypes, and a clinical content review of the re\nformatted reviews [16]. erative fos groups were then\nconducted inorder to line the faa of the ploype,\nfollowed by waht testing to tt the layout design, ad\nresentation dara inal sessions [17,18 The foes\ngroups and uslity testing were camplted with pear\nae physicians and relnerents were made la a ince\nental process, flowing each round of data callecion. A\nse stidy inched ia the fest shortened format 1\npresent contextualized information (ese-based. fora)\nnd the second shortened fonnatintegtes evidence and\nSinical expertise (eidence-expert format) This tert\nevelopment proces ented component erent of the\nyout and placement of information resulting in tempat\nor each ofthe shortened frat As a seal tempi\nwere Mentied that canbe used wit idvidal ate\nenarmapahenteiptnonkermsivn", "ee See eee eee 2s\nhe pt tiny fromm a tof rece published epsterat\n‘eviews supplied by the Health Information Unit at", "BZ measure independent reviewers agreement of\nrespondent answers with a kappa state of 60\n‘or greater. Values of kappa between 040 and 059\nhave been considered to reflect fr agreement,\nbetween O60 and 0:74 to reflect god aprement\nand 075 of move ta reflect excelent agreement [22\n\n2. To ecru toa of 5 physicians for participation\nwithin month tine frame,\n\n3 To have 280 of participants who started the plot\nstudy eead the systematie review and complete the\n‘questions elated tothe linia senaeio within a\ntae,", "Objectives", "Methods", "Description of pilot study" ]

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[ 1, 1, 1, 1, 1, 1, 3, 2, 2, 2 ]

[ "where is geographically Close to the South China Sea.\nThe ation suggest hat Lujan aan night feed cope\nnods, shrimpe and inall pelagie fishes in coral ecosystem.", "ratty acid’ signature Tas been increasingly used’ to study\nhe diet of ¢ umber of marine species. The peseal\ndy suggests that dit ofthe coral fish species Lada\nnus luianns changed in acordance with growth. Fur\nhermore,diferences sity aid peas night not jst\npe considered wih respect to the dit, but might be\npased on the hablat and migration. Further studs ae\nneeded to study for various organises in oral ecoys\nmusing fatty ach signature for understanding Ife his\nocr ond eculces delete $a the comel See eaclon", "sonadlosomadic tne (St) Hor each leh was colcued\nsth tn seme", "Ai Specimens of the Digeye snapper Cutjanus lutjanus\nwere cillected atthe Bidong Island in the South Chin\nSea, Malaysia (0537 12\" N, 1030412\") between 27\nsnd 28 October 2013 (Figure 4). Bidoag Ishnd located\nff Terengganu State on the east coset of Penineula\nMalaysia, Known fr is well-developed coral ret ecoeys\nJems thal support variety af coral and rocky reef aso\ndated fishes [10]. AU shes were collected by means of\nih taps and hook and line. After collecting, ll fishes\nweze immediately stored in ice chest, brought buck 1\naboratory, were kept in 20 feeze. Fatty acid ana\nyses were conduct within one month after sampling.\nA toll of 45 fish samples were measured in total length\nTL), Body weight (BW), and each sh was dissected i\nder to determine er and gonad weights (Tale 1). I\nhe present study, hes were categorised as ether ara\ndum of large acording to thei ses Table 1) Sto\nee eth Sek ce rice De fs mt ec", "Liver samples of Lujenme iajaunr wire ensiyeed for\ntty seid compostion fllowing the ane sep method\n9-1] Liver samples were combined to frm pooled is\nse simples for each size group. The sample ses o\nsmall, medium and large groups were tvee, seven and\na, respectively (Table 2 Each Wer sample was med\nvith dtl of hexane (Merck, Germany) and 1 al of i\nema standard solution ina 50m centrifuge tube. After\n1dding 2 ml of 14% BES in methandl, the tube was\nshed with nitrogen gas. The capped tube was hested\nna hotplate at 10°C for 120 mi. One ml of hexane\nvas added followed by 2 ml of dstled water. The tbe\nwas then shaken vigorously for 1 min and centrifuged\nMSE Haveer 15/80, MSE Ltd United Kingdom) fo\nSinan at D0 epi", "Samples were then analysed using a tn) AGE he.\nShimazu, Japan. Separation was peeformed with an\nFFAP pola capllry column (30m 032 mum ine\nameter, 0.25 mln thickness). Hydrogen Was used 36 3\ner gas. AMler injection a 6, the oven temperature\nvat raed to 19°C at rate 40°C mi then to 24°C a\nC min and aly held constant foe 30 min. The fare\nrization was held’ at 240°C. Peaks were Mente by\ncomparing thee eetenton tines with those of authentic\nstandards (Supelco Inc, Sigma Aldsich, USA). Fat acid\nvere designated at an pax, where i the number of\nbon atoms in the aliphatic chain, is the number of\njouble bonds and x is the poaition of the fst double bond", "gg ee — eee\net of Pentrauls Malaysia,", "| BSS", "Conclusions", "Methods", "Fish", "Patty acid analysis" ]

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[ 8112.632958178176, 27375.05562210735, 3338.8773959408863, 50249.258184293285, 39981.804950259626, 36132.396497350186, 4975.370575970679, 81713.42789890981, 647.5971241600055, 473.98784110001, 166.00634797482053, 764.7243824126781 ]

[ 1, 1, 1, 1, 1, 1, 1, 5, 2, 2, 2, 2 ]

[ "Re eal WEIS EM fae tereanee! ny to EMr\n2.6%) stimulation. In women, only Blue stimulation\nyoked increase in MEV in the RMCA (26%) and\nIMCA (22%),", "One MANOVA was applied to MEY dats set 80 assess\nferences between measurements in the RMCA and\nLMCA in men and wormen, with a2 x 5 x 2 design\nwo lees of GENDER (Men and Women), ve levels of\nSTIMULATIONS, (Dark, Light, Blue, Yellow, and Red)\nund two levels of ARTERY (RMCA and LMCA). The\nMEV was analyzed a che dependent varable, There was\n| main effect of GENDER, F198) = 65:4, MSE = 68166,\np< 0.0001. There was 4 main elfect of STIMULA.\nTIONS, A376) = 56, MSE = 1117, P< O01. Ther\nwh 0 mala eet of ARTERY, P = NS. However, there\nwat STIMULATION x ARTERY interaction, F376) =\n83, MSE = 596, P < 0.05.", "PAS Si Semenreirs te Caveman Spec\nJensity plots for each artery during Dark, Light, Blu\nand Yellow stimulations in men (Figures 2A-B) and\nwomen (Fgutes 2C-D), respectively In general oral\ntimulations in bath ron and women there were thre\npeaks designated as fundamental (F-pea), coral (C\npeak) nd subcortical (S-pea), which occured at eeu\nar fequency intervals ofthe fest (0.125 Ha), second\n0.25 Ha) and third (0375 Hz) harmonies, respectively\nGiven the differentisl MEV response in men and\nwomen, the spectral density estimates for men and\nwomen were analyzed separately, to uncover changes 3\nvertical and subcoetical peake", "Eat Shiene, eae 6 Rraieaey Ok aubcOkeen Pee 6 Be\nhigher than cortial peaks in men. There was 4 man\nlect of STIMULATIONS, FU,24) = 12, MSE ~ 11586,\nP <OO1. These was no main elfet of ARTERIES, P~\nNS. There was 4 REGIONS » STIMULATIONS inter\nion, FA24) = 48, MSE = 31945, P<OOI. There wis no\nREGIONS x ARTERIES interaction, P= NS, There wi\n, STIMULATIONS x ARTERIES interaction, F24) =\n17, MSE = 7397, P ct. Thee was a Uee-way intr\nsion, REGIONS » STIMULATIONS » ARTERIES, F\n424) = 476, MSE = 25392, P <DOL. Figures 3(A-D)\nhows the plat of means ofthe three-way interaction of\nhe spectral denuity estimates for all study conditions at", "A MANONA With repeated measures was applied to\npects density estimates in a 2 x 5 x 2 design two\nevel of REGIONS (Corteal, Subcortia, fie levels o\nSTIMULATIONS (Dark, Light, Blue, Yellow and Red)\nund two levels of ARTERIES (RMCA and LMCA). I\nsen, tare wus no aisle ofect of MEGIObE, Fb", "pagure 2 (0-0) displays the conventional overtaid spectral\nark Ugh le an Yellow im men igure 24 nd\nSe lac ieth cae,", "Figure 3 (4:0) shows the plot of means of the thseway\ntraction of he seca deraty estimate or al tay\nons 2 pecan Sens ken Figure 3h and\ntine oe Dh mepesaly", "elete 7 Been 68 endl Perma Gonteets of ley\nchanges during Visual Simulations from Dark Basen", "", "", "i" ]

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[ 8823.555822736293, 34484.12331124465, 34681.625026857946, 36097.28340747673, 16420.321376882493, 7190.336030792911, 7296.938385700807, 5398.009977602749, 37507.22533965568, 40580.616834000044, 38284.46756531997 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 4, 5, 5 ]

[ "Table 1 Immunology genes modulated by IGKV3-20 at 24 h", "Doweregulted fleft) asd upregulated (ght) genes.", "aoe 0 Sew eel ere ae ea\n\na\n\npnt Co Chemokine car? aria ADORE Adare Ansgar\n\nso CIR Campa far ep 012 kmh ao\n\npias Caine sa 18k be\n\nusr C8 Gyeeme 2 tapenade S024 LR Teper ano\n\n70 ay gehen 2 Dasa km 2 ep, aa\n\nese FAH Furano ene SHED nk 6\n\nused FHP Fatman «STREAK ear?\n\nnee FUCA Fuse phat te 295120 MMOT Mara mealapepcie?\n\n5074 FD Fuse pha pena «120 NPN ne\n\nUs GTA cpt ape Dosn74 NB? Re cc apse pepe ene\nSiig taupe Inde pss\n\nmnie GN Gal, owe oa Pope eta\n\nos HSE Het oh esr7s Pc Pegdn reap\n\nise HAGMAN a Od Dan274 16S? Psapp me?\n\nicin NGPA HC a LP at mss Soo? Spouse rate?\n\naM NORA HC aw OR eat EAP TN abode on\n\nseis Htc eens + Darr? REREB TN cp ipety Ib\n\nem UKEP Iain dg pte SMS TAF TNF capri ment\n\neee GRD amg tn? ess TRAP TN epanace fe\n\npsoi2 GK agin aS\n\nust RCI Hana mentonC ype\n\nMON SRI Naoopage eee\n\npm MAGA Nacnconrmndne 2\n\nmn NER Nga tale or\n\nya Matalin\n\nou TRS ———_Tolitbercapcr" ]

[ [ 56.69, 88.37, 296.98, 98.68 ], [ 56.69, 722.33, 214.07, 730.2 ], [ 56.69, 100.82, 538.5799999999999, 720.76 ] ]

[ 2476.217304000049, 1239.367526240443, 298741.9926677306 ]

[ 1, 1, 4 ]

[ "ponsuitadon) and stall type (eg. Gl practice nurse,\netal hel aurse,dstict nurse) and then assigned an\nerage costs listed in the Unit Cost of Health and So\nial Care 2010 from the Personal Social Services Re\ncach Unit (PSSRU) [31], Where average cost pee hou\nvas the oalycost published inthe Unit Costs af Health\nind Socal Care, the UK GP workload survey [22] wa\ntse in order to determine the average length of the\nconsultation. From ths ire, the average cast per com\n‘idlan could Ve clea", "ee ee oe oe a eee\nsdmisions. From the care pathway outline inthe NICE\nidelines for ADHD, we would not expect patients to\npe routinely adnited to hosptal as a dee eesult of\nheir ADHD [16]. However, chile and adolescents\nvith ADHD may be mone prone to other problems se\ntring adknloslon ouch in wecldaete we eattoeen Thad", "L shales palice miasraenesqambmirie tareselabtediat and\npocesed into Healthcare Resource Groupe (HRGS) ising\nHIG-+ grouper [23], The HRGs were then matched to\nNHS Reference Coss 2009-2010 [3] It was not possbl\n2 diferente between electhe or emergency diy-as\njdlaions from the dat avilable, and ao costs wer\nseraged by ratio of ech admission type. Dats on proce\nues were not avalale snd 40 all costs were inated by\n175 the average diference between procedural and\nnon-procedural admissions.", "pres Xe Coenen Ae Se eee oe ee\nes sala Bemduns chasactacielins um diated ic he", "EE? cance with ADHD and 7427 matched control par\nsens were enti in CDRD (Table 1). The mean age a\nJagnoala was 10.4 (ad 59) years for cases and 10.4 (61)", "i Ney Nine, ean, Neicisierice, Oe ee erent Bene\nages was 69 cases per 100.000 population (perk\nFigure 1). This peaked in 2007, with 122 eases perl00k\nan increase af 78%). Overall, the incidence of diagnosed\nADHD had fallen by 200 to BS per00k (an increase of\n28% reve to 1999, The idence of diagnosed ADHD\na chdren and adolescents aged 6 to 17 years incensed\norm 383 pert in 1998 to 780 pert0 (10145 increase\nsig 1998 as a eeference) in 2007 before decreasing t\n9,7 per 100k (52% increase rom 1938) a 2010 (Figure Ib)\na 1998, the incidence of ADD was 10 tines Hager i\nales than in females fr patents age 6 to 17 years bu\nnly ve ties higher in 2010. The incidence eaten adults\nvas much lower than for pallens aged 6 to 17 years and\nnezeased from 0.2 per100k in 1998 to 1.1 pert00k (3938\nzeae rom 198) 2008 before fling to 09 per00k\n86%) in 2010 (Figure 1) For alls, he incidence rat\nmals ws 1 tines higher than in eas 198 bt\naly 1.1 times higher ia 2008, The lacidence of tested\nADHD was 48 perl00k in 1998 and reached 2 peak of\n118 pertO0k (145%) in 2007 (igure 2} before decreasing\n10 1011 peri00k (109%) in 2010,", "cone verah Prevalence (and percentage Change using\n1998 as the reference) of dagnosed ADHD increased\nrun 305 perlO0k kn 1988 to 889 per100K (1928) in\n2007 (Figure. 3a). The pretalence then fell to 815\nper 100k (167%) in 2009 (Figure 3a). The dlagnosed pee\nlence of ADHD was much higher in children aged 6\n2 17 years than in adults. However, the prevalence in\naries tc ete pices batman 1608 und SOOT. ba 2958", "Figure 4 Distribution of healthcare costs im the first year following index date", "ie", "Hospital admissions", "", "of diagnosed ADHD\nIncidence and prevalence of diagr" ]

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[ 26428.387050334655, 19241.43031590688, 26240.03453799477, 5307.217050250911, 8174.687873248127, 60202.28177748015, 22100.965640508104, 2481.165286033589, 96088.66679275548, 833.2116068404721, 384.2192571499909, 1927.4412966945965 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 5, 2, 2, 2 ]

[ "Sopttved quintile G.3% in 1993 to 3.3% i 2010) and\neatest forthe least deprived quintile (3.6% in 1993 19\n7.1% in 2012) (Figure 3),", "residing in the least deprived quintile increased) across the\nuy period (PR: 1.25, 98% CL 220 1.29 in 2008-2012\nceed win: 13-0071 Chie).", "ieepreicihhiaetpal stars: dacaeiemreemanerdvaienn adhere\ndenis being inthe oldest age group (ver 85 yeas increased\nover the study piod (PR: 1.43, 95% CL 1.39 10 148 in\n2008-2012 compa with 1999-1997) Among decedents\nwith caper conditions, ivepancreatc cancers increased\nmast ovr de time potiod (PR: 1.34, 98°C. 1.3010 138i\n2008-2012 compaed with 1993-1997), However, the bis\n\ngst increase Was for nocancer condition (PR: LAL, 98%\nCl: 1.37 to 146). The likelihood of hospice decedents", "This population-based study of inpatient hospice deaths\nnas shown that bah the absolute and elative numbers of\npople dying i inpatient hospices in England increased\nprice 1998 and 2012, though numbers remain Low with\nust 6.0% ofall deaths in 2012 occurring in an inpatient\nhospice. Although there has been a recent increase in the", "eee ee Ne a ee ae MAGSIS), 1993-1997 (08 97.523),\n1998-2002 (n= 11 1.248), 2003-2007 (n= 1 14,842) and 2008-2012 (n= 123,202). ’", "", "aes 8 oe ae Nolen WM\nen ruts 506 49les 50S su287 S06 S899 Soy sis, «so\nrset (30) 699 (124) — 99125) mare)\nyer)\nhae soup (er)\nSine soles Bauman, 7B wD 77 90 el\nGauoinsnim! 98492 «19920552211 22453104 AI? IT ATS\nTae wa 197 21m aa 10) 21388— tw 214807\nee a7 196 200% © 206 0 199 Ale 9S N00 a\nwe sia 205 i971 203. 379 aa HssT— 206 25703208\nSe ea eras) 98 1698917521329 92, 28020309212", "Discussion" ]

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[ 6652.2332999999635, 7205.221199999796, 24974.324100000318, 16712.386799999513, 7972.076184468198, 696.0055679999932, 219542.2956, 829.3557599999476 ]

[ 1, 1, 1, 1, 1, 1, 4, 2 ]

[ "GP stated that (s)he “wouldn't normally prescribe dis\noot tne welt oon”", "Second, there war controversy Shoat whedher ACK\nJhould be prescribed in primary cate in this age group,\nvith one saying (he “usually not prescribe for chit\nren” and another saying (s)he avoided orstat\"wheve\nposible.” Meuformin wat wed elther “on advice of\nspecialist only.\" or had specialist follow-up after initiation.", "Thied, CFs noted comcem shout the eilicacy of these\ndays “Inadequate counseling” lack of dg availability\nud patient compliance (eleatly patient yas Hot able to\nSema\") wears lorpiePhadlenl tauren loc Saetiedtineme,", "Sixty-two GPs wanted improved support, primarily split\nita two nisin chemnes. Ft, they requested improved\nagetelated guidance for prescribing AOD that i \"teal\n\nst’, with ‘clear [and] concise’ advice including “ow\ndiagrams’ and ‘stepwise advice” This would include\n\nstructions on asessment prior to initiation, indication\nindications, containdications, monitoring, safety adie,\nduration, targets and indications for stopping weatment\n\nSecond, they wanted improved guidance for managing\npatients with obesity, namely advice about. Wexye\n\nmanagement and deta of available interventions. GPs\nrequested details of “non-drug weatments” including\ncommunity support for adolescents” and “special clini\nor monitoring and support of patients” One GP high\n\nghted that “nowarug Weatments need to be key along\n\nie ewe oeeaee”", "Tels bs detailed cade of primary core prescciing\nof AODs in CXP at the individual patient level Suna\nnumbers of prescriptions were ised in this age group,\nwth most practices surveyed prescribing just a single\nAOD to acid of young person. However, lear patterns\nwere detected that can help guide preseribing of current\nand future generations of AODs.", "major prescribing patterns were seen: arilseat was\nargely initiated independently to those over 15 years,\nsnd metformin was largely recommended by special\nsts to girls with either poljeyse ovarian syndzame or\nsturbances in glucose homeostasis. Comparison with\nNICE guidelines for orlistat showed lowe compliance\nvith national prescribing recommendations, namely\now prevalence of camorbidides and drug initiation\nwithout specialist advice. Given that most orlistat\nprescriptions were for thoae above 16 years, it could be\nhypothesised that thove aged 16 years and over were\nreated as adults, with drugs prescribed in line with\nadult guidelines that do not necesitate presence of\nsencruiitien", "Recipients oF om ACK) were largely female, with\nwo-thirds (65%) of the sample aged 16 or aver. Two", "Our Radings sagment the very limited existing data\n‘lating to AOD rates of inilation and cessation’ and\nexperiences of XP presctibedan AOD.’ A paired study\nby our research eam investigating patient experiences\nof AODs found high levels of side effets low levels of\nprofesional support managing these side effects, and\nslimately families deciding to stop the AOD due to\nthe disadvantages of the side effects outweighing the\nperceived benefits of the drugs.” This conteasts with\nndings fom tis study where no patients actively\ndiscussed sde effect profiles with their GPs, and GPs\nbeing aware of side effects in only two patients. This\nsnudy docs not explsin the disconnect between the\nexperiences of patients and clinicians, and further\nwork should exatnine ways vo support families so they\nie able to eflectively manage the side effects of these\n‘rugs.", "GPs reported low confidence in prescribing AOD to\nCYP, despite high evelsof confidence when prescribing\n0 adults, This fits with findings from our paired\ndy, which showed that families notice this unease\npritary care, and which can result in heightened\njunilial concerns about AOD usage.’ GPs reported 4\ndesire for improved guidance on drug initiation and\nmonitoring, and on lifestyle interventions, implying", "rigure 4 Festogram summarising generat practitioner confidence in prescribing antlobesity drug to children and young people\nset and odulta Gott),", "‘ua.’ fl", "DISCUSSION" ]

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[ 3972.278639999975, 17701.02720000001, 11695.140000000014, 45675.24367999984, 19581.237359999912, 40390.36441999953, 5813.395380000002, 49035.272461785935, 24227.157263998874, 6416.024191948469, 60958.30768008006, 574.9620000000141 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 5, 2 ]

[ "ey enperties To pases the eicacy of coamputed tomogapy £1) in aeelusing peients with pancesti", "Seta We User & Rapective melee Of pil Eakin Peers SCATINRN > Wap Chae Mieco\nCenter fom January 2004 1 June 2006, Every patients underwent abdominal CT scan in emergency depariment\nandthe CT scans wee obzained witha foursice heleal CT. Dagnosis ofa panceatic injury i these patents wa\nBy surgical observation o by CT findings Raciogaphie pancreatic injunes were casiled as deep superical\nsion Deep lesans were dened ar the hematomas or lacratone >S0 thickness ofthe ances. Supe\nesions were described asthe hematomas or lacerations <SU thickness of the pancreas, pancreatic edema; and\ntocol fui sccurruletion wound te pencees", "Results: Ninetzen patients with pancrestic trauma, fourteen males and five females, average age 40:6: 21.4 years,\nwere included. Most patents (737%) with pancreabe trauma had associated organ injuries CT was performed in al\npatents and laparotomy in 14 patents. CT was 72% seneve mn detecting pancesti rauma, All deep pancreatic\nsons revealed on CT requted sugcal westment and complcaton was dscovered in two patents undergong\ndelayed surgery. Superficial lesions were managed conservatively.", "emer a ee ee oe ea Cee roa Peed Tepe 2) Fae, Dee tees Teepe OUNaE.\nDelayed operation might result in complications and Is associated with prolonged hospital stays", "Pamcneetic trams Se TRCHRMRON RAM BLOT TEHNELA SE\nscons have lite experience in managing the condition\n12}, To complicated matters, most patients with pa\nreal trauma have concomitant injures, [2] which fe\nquently obscure the symptoms of pancreaue tau and\ndetract the attention af the trtma surgeon. Serum\ntylae and lipase tents have been proved either sens\nsve nor specifi [A]. Maccover, the pancreas deeply\ncated i the retroperitoncur and there ae difficulties\nsing physical examination, sonography and diagnostic\nsesaa looms te lnesliete Oe wo [LEA", "organ injuries require CT imaging. However, the reliability\nCCT in detecting pancreatic trauma ie atill debated [7-9]", "Norse Computed’ tomography scanning (.') is cur-\nently the most useful tal in evaluating patients who\npave sustained torso trauma. The majrity of stable\nauma patients with a high auspicion of intra-abdominal", "REAE ns eco Eee WO aneee. ie eeicacy OF Coe\nsvauating patients with pancreatic trauma and examine\nnow CT findings influence the management of thew\nvetionte,", "7 us sttidy was approved by the institutiona® ieview\nBoard of Chi-Mei Medial Center. We performed 3 ee\noapective chart review inal blunt trauma patient\nsited to Chi-Mel Medial Center from aly 2003 t\nSeptember 2006. Papers and electonle medical seco\nwere searched by the five authors to ently the eases\nof pancreatic injury. Diagnosis af a pancreatic injury i\nhese patents was by surgical observation (14 patents)\no by CT findings (5 patents). Every patients underwent\nibdorninal CT scan in emergency department and the\nCT sean were obtained with a helical CT(Four Sic:\nHliSpeed CT, GE). All patients received intravenous", "wmeh—x", "Wei-Jing Lee, Ning-Ping Foo, Hung-Jung Lin, Yen-Chang Huang, Kuo-Tai Chen:", "The efficacy of four-slice helical CT in evaluating\npancreatic trauma: a single institution experience", "Abstract", "introduction", "Methods" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 2 ]

[ "Seaustica! anayss. 'npaired’ i-tests were perlormed using\nMicrosoft Excel to determine the statistical significance\nof quantified data. Resuls ae preseated asthe mean of\nnce individual experiments with standard err of\nmean (SEM) and p value < 0.05 considered significant.", "2O wet 5 SGN microspheres We perlormed’ @ one-step\nethanol immersion method, Ethanol was added to TIPS\nmicrospheres suspended in serum-supplemented cell\nculture medium. ‘The sinking of microspheres in\nmedium was wed 38 an indicator of wetting. as prvi\nously described 2?", "Milcrospheres were wetted with 2270 {viv}, Wve (viv)\nand 100% industrial methylated pits containing 9%\nethanol) over 30 min, 3 h and 24 time periods, under\nstandard culture editions (37°C, 3% COs, 95% humid\niy). We obsred thit_microsphere preweting. was\ndependent on ethanol concentration and the length\nGOmin, 3h and Mh) of the wetting procedure\nMicrospheres exposed t 70% (vs) and 100% ethan\nbecame immersc in medium containing 20% FES) afer\n3h, but thos expose o 35% y) ethano required 24\nbefore they were completely submerged (Figure 2).", "ee ee ee\nwetting can be mexifed to various extents by altering\ncanal concentrations and exposure times with thi\nwlvent. To our knowledge, our study is the fst to\nShow that dose- and time-dependent exposure 1 eth\nsai eum be peed 1o wet PLGA TRS ecbronceres,", "See ea ee ee ee is\nhydrophilation of hydrophobic polymers.\" We\ntherefore, investigated the correlation between Serum\nprotein adsorption and wetness of PLGA TIPS micro\nspheres. Microsphetes wore incubated with 38% (7)\nor 70% (vs) ethanol in medium containing 2%, 10%\nand 20% serum (FBS).", "crosperes Decame compiciely SUDMerECe in ve\n(uy) and 10% (4x) FBS preparations (with 70%\nethanol fr wetting after 3h, But those exposed 10 29% (\n») FS became immersed in medium after 24h (Figure\n3.) After 3 himicrosphers exposed to 20% (/¥Jor 10%\nvi) FBS adsorbed similar amounts of peotsin approxi\nmately 24g total protein} and a signifcandy lower\n(p= 0.05) amount of protein approximately 14s tua\nprotein) ws adsorbed to those exposed 0 2% (s/s) FBS\n(Figure 3b). Under conditions applying 38% (vv) eth\nnol that allowed only partial wetting of microspheres\nmicrospheres di not sink after 3h (Figure 4). Instead\nter 24h proportion of microspheres treated with 2%\nFBS and 35% or 70% ethanol Bocane submerged, bu\nthe majority of thowe treated with 20% FBS including\n35% of 70% ethanol sank in medium (Figure 4),", "ope ae ee ee\nand those ated with 20% FBS-+38% cthanol\nidsorbed similar amounts of serum” prosins\n(Figure 5). By contrast after 3 incubation, micro\nspheres weated with 20% FBS + 70% ethanol adsorbed\nnificantly greater (p= 001) amounts of serum pro-\ncin than those treated with 20% FBS + 35% ethanol\nmaapweting thet the inssenaed wotuem of micreaphese", "Se cece ter at oc nee ee nee kee Oana th on Whee hen olatad Meera Ben On che, i oo Mab Reames og\nmum cantaning OX, 2% or 20% FAS and treated with 39% (9) or TOK wy) ethane! (ECON), for 30min 3 and 24h Arrows ad", "S08 AE\n20", "mesults", "WUOEINg Of Titan mECrospreres & enmance? Well\nexposure to increasing concentrations of ethanol", "serum protem coerpton to Fifah minapneres\naccelerates wetting" ]

[ [ 62.36, 297.62, 297.66, 355.21000000000004 ], [ 62.36, 429.15, 297.62, 498.7 ], [ 62.36, 500.93, 297.68, 630.1800000000001 ], [ 62.36, 632.4, 297.62, 701.9499999999999 ], [ 310.39, 333.51, 545.69, 415.03 ], [ 310.39, 417.25, 545.76, 606.31 ], [ 310.39, 607.13, 545.67, 701.95 ], [ 62.36, 256.9, 545.67, 287.28999999999996 ], [ 65.69, 68.61, 542.26, 246.26999999999998 ], [ 62.36, 378.61, 102.31, 389.8 ], [ 62.36, 396.39, 281.32, 421.65999999999997 ], [ 310.39, 300.75, 528.63, 326.02 ] ]

[ 13546.541528803646, 14456.604981896118, 29915.394836173626, 15998.706165849697, 17556.443109053886, 43975.119267957285, 22165.86720566172, 13745.098640183278, 84668.58064855004, 447.0835808138654, 5522.997133247904, 3667.338158066792 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 5, 2, 2, 2 ]

[ "eet < eS ee ee ee ee\nanging fom “never” (nthe past 3 months) to \"daly o\nmost daly\", whereas Questions 6 and 7 use thee\ngory rating (\"no never’ “yes in the past 3 months\nyes bul notin the pas 3 months) The aa sere cl\nculated asthe aura of scones received for Questions 2\nthrough 7 inclusive, ie bound to measure one latent Cc\nothe specie substance invalverent score as defined\npy the ASSIST, here the cannabis involvement score.", "nis scare enabled’ us to identity three groups Of Can\nits eae", "a Ee ee Soca, Scences,\nSPSS Inc, Chicago, IL) and AMOS 19.0 (Analysis o\nMoment Stuctures SPSS Ine, Chicago, IL) software\nprograms were used to perform the statstieal analyse,\nThe dstibuton of se repoted canmabis use was com\nvared by type af survey using 4? teats,", "ee See ee ey ee eee\nthe Web survey by Cronbach alpha coelicient\ndely, «should be above 0:70, but ack mich higher\nnoe ae", "separately, from witch the conligural mode’ is derived.\nGiven that one of cur research questions concern\nmeasurement equivalence across groups, statistical ana\nses focus on configura Invariance and measurement", "ERE Ee Ey SECS PONE, WE HANG Ve\nteuctural equation modeling (SEM) procedure described\nby Jieskog [4]. Depending on the research question,\narching for group equivalence may imply 2 series of\nst performed in the following restrictive order: cong\nwal equivalence, measurement equivalence, and stu\nural equvalence, Confqural invariance tesing focused\nithe extent to which the number of factor and the\npattern of thee structure are sar between groups. I\nesting for measurement and structural invariance, we\njocused more specially an the extent to which param\ntre inthe metaurement and structural components of\nhe model are equivalent across groups [19-51) It\nwocth noting. however, thatthe determination of an ap\nvropeiate baseline model ie required foe each group", "A mendes goodness of St ly exomdned thacmgh various\nindices, a8 described below [52-54]:", "Changes In goodnen-cFi® mtatitice were 9p exam\nned to detect differences in the models. A sigan\nllference in values between nested models means\nhat all equality constants do ot hold across. the\nroups. Since the vatables are measured on an ordinal\nale with relatively few categorie and the values be\nween eategories are not equldstant, asymptote\nlistibutiorfee estimation instead of maximum lke\npood etination was used here as one ofthe sree\nip ucceamnadiae usa-usrmely Satineiea dan", "Sample size plays an important role in providing un-\npase parameter estimates and accurate mode infor\nmation. Bentler and Chou [55] recommended a rai o\nleast 5 of subjects to variables for noemal and ell\nscl dstubutions, and thre seems to be a general con\ncensus among researchers to adopt this ral, Howeves,\njor categorical or non-normal dstabuted variables, 3\nthe ease ere, lege samples are required than fo\ncontinuous or normaly disteibued variables, A eat o\nleast 10 subjects per variable for ths type af dstabu\nion is recommended [5556]. The sample in the curent\nstudy fulfila this requirement.", "© sample oF 1382 persons participated in the web stucy.\nwherets 150 persons fled in the PaP questionnaire. In\nhe Web survey, 1% of the participants were exclded\npecause of missing dal, leaving a sample size af 1366\natthe analysis There were no missing daa in the DaP\nmn", "“were were staristica 'y sign icant diberences between\nhe to groups forall ASSIST questions (Table 1), Par\nscipants rom the Web survey seored higher on all", "on nee ee ee ee ee\n‘expressed concern about your use of cannabis?\n\nQ7- Have you ever tried 0 cote cut dawn o top\n‘using eaneabie?", "=. PAE ER: ACRE ORL ie aE as Leow Tee,\nof ealth and other problems fom hse current\npattern of se\n\n- Moderate isk (core: 4-26): The ptipant is at\nrik of heath and oer peoblems em hier\ncurvent pattern of substance we.\n\n- Highs (Score =27): The partlpant sat ih ri\nof expevincing severe problems health, soi\nfancil, egalrelaionship seul of hither\n‘coun vaca af ans tcl lb Maly tobe degen:", "a. The x’ to degrees of freedom ratio (y'/dt)\n\n) The comparative ft index (CH)\n\nThe oot mean square eroe of approximation\n(RMSEA)", "Statistical analyses", "Evaluation of model fit", "Sample size considerations", "", "Cannabis use" ]

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[ "Pe TIES SORSEEERE (WNOAES) hee Senet See\nity af herbaceous vascular pants (see Table 3) as com\npred to rest ofthe communities, despite the influence of\nsnthropogenie disturbances. Some factors like sil qual-\n1; forest product, Nat favorable topography, and\nwerlapping of diferent plant assemblages forming an\nscotone of evergieen coniferous fret and xed broad-\njeaved forest of the lower elevation region atibute for is\nich floristic diversity", "The coniierons wendiand, Abine—Jivediadinedres Com\nuit, she least species rch community (se Table 3)\nAdhikai (2005) reported that seeding establishment of\nhe dominant species, A. densa Griff, of this community", "Table 1 Classification of study plots", "etnies Mepatcecs Mnctientst Sedecriptes", "one Lindl. Jensiparns op. Mrededesdren op. end Ber-\nbers sp and herbaceous plats ke Fragaria dale\ntiana J.Gay, Primula spp, Gaulherateichopyla\nRoyle, and Arisaema lephas Buchel ate seen an is\nround Moos\n\nJuniperus Sera Comnmuniy (Pat 7-8)\n‘This fs small community forming above timber\nline vegetation (Figures 4, 50 Mainly composed\nof Juniperus recurve Buch Ham. ex D. Don and\n‘quamata Bch-Hamn. ex D.Don, tis tnaderatly to\nIighly scattered vegetation (Table 3). Gentana sp.\nand Rhodadendron nivale Hook. (are sine other\nCommon species found in such community\n\nt Rhododendron Krumsmhal Community (lot 9-10)\n‘The Rhdadendron heumoubole is another type of\ncommunity forming. abive timberline vegetation\nwith arch growth of bryophytes on ite ground fooe\n(Figure Se). Keammhols here is referred to a8 the\n‘crooked snd contorted forest formed by the effect of\nthe wind current (Figure Sd), It isa fey mined vege\ntation of sparse and dense dstibution of Rhodaden\ndion sp. Open grounds, gaps, and margins of such\ncommunity unuly have high diversity of herbs\neous vascular plats (Table 3)- Potent saute\n‘ana vat. eaesptosa (Lehn) Th. Wall Primula sp.\nBergen purpurascens (Hook. £ & Thomson) Ea\nOxygrapisendicheri (Walp) Bennet & Summ. Chan\ndraare same other taxa found inthis type of oma\niy\n\n5 Alpine meadow Community (Pot 11-12)\n“The Alpine Community (lo see Figures 4,5) of he\n“Merak Himalaya has a hgh diversity of eebaceous\nvascular plans (Table 3). This fag natural moun\nTain meadow fe mostly adoened by the abundant\ngrowth of PotentilacortandifoliaD. Don, Bistrta\nSpe Chanantlas macrocalyx subsp. spathuliflis\n(Nant) KK Shrestha, shrubby Rhododendron seo\nsum D. Don, and numerous species of unidentied\nesses", "1. Riverine community (Piet 1)\nSuch type of community usually occurs alongside\nthe versteams (Figures 3,4, 5a), where some of ts\npotion experiences severe flooding duting the heavy\n‘moasoun. ti composed of multiple micahabiats\nSuch 35 terse Serubs, open ground, and aquatic.\nterrestrial transition, Most common teeta plants\nadorning auch community are Senecio raphanfolas\nWall x DC, Rhododendron campylocarpur Hook,\n{, Rumes nepalents Spreng. Pedicularssiphonan\ntha D- Dos, snd Geranium spp. Mricaria rosea W.\nWS, Cardamine gif Hook. £& Thomson and\nEpilobium gous PH. Raven ste some aqualic-ter\nrest tation plats. Fragaria mubicola (Hook.\n£) Lindl ex Lacata and Anaplals spp. are among\nthe herbaceous plants chat occupy the open ground\nhabit\n\n2. Abies-Rhodadendron Connuniy (Pat 2-6)\n\n‘This type of community is eather restricted tothe\nwoodland habitat with sparsely occurring epiphytic\neens and dense bryophytes. Its maa composed of\n1 single tee species A. densa Grif—with high can-\n‘py and Rhododendron sp. as moderate accpants\nforming ts understory vegetation (Figures 4,5, 6)\nSuch vegetation is usally filly with slopes of 245°\n(lable 3. A very few species of sheubs like Rosa ser" ]

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[ 24139.824306531344, 11810.309987532906, 1590.6801110992928, 65055.54211552326, 94862.08609481156, 65053.36219554581 ]

[ 1, 1, 1, 4, 3, 3 ]

[ "The interactions saagng the pacnmneters on the geuczt\nil rejection and permeate Max in Ueee dimensional\nurfce plote and two dimensonsl contour plots ar\nee ks Fees § ad", "a a ee a\ncular weights of the antibiotics compounds, The best\njection wis oblalned for aml (936%), which has\nhigher molecular weight than ampilin (3654 g/moh.\nThere i consenas chat nonionazable orp oles with\nmolecular weights between 200 and 400 ginal at\nficiently rejected by RO/NF membranes [39,40}", "oe ee Sen Fe eee ee eee\nate fax and ejection. Higher x values were oblaned\n13 bar for appled amouein and ampicilin (1854\nLh, (Tables 3 and 4 far amon and ampiii,\nrespectively).", "eS es ee ee eee Soe\n13 bar would lad the fe to increase as we which was\nue to the soluton-dlifision model. Aso, the condensed\nmembrane increases the stale reitnce and then mor\nluts ae ejected 1] On the oer hand, Dx under the\nperimental conditions aso a fancion of a etention,\nthe read fons acute in the boundary lye of\nhe membeane where the concentration polarization efi\nsmposes a esate pressure and edu the effective\nving force scons the membrane [2], By increasing feed\nese, the diving frce wil increase and the overcame\nSercienss taldeun DAORARAM, a Gee ee eceecic", "MID respect to The experimental concliions used in this\nstudy, the Prue ( 0.00) showed thatthe pressure and\npH have significant eff on the rection of amoxil\nsed ampiclin indiduly, But all interaction llc\nmong the operating parameters inthis study were isi\ncant for selected anil rection. AS presented i\nTables (5 and 6), salu forall Iterations were high\nhain 0.", "Retention of ongenic pelltents in merabeane peper-\nlon processes depends on the characteristics of both\nmembrane and the pollutant [5] In addon, most of\nhe papers reviewed by Bellona etal. have showe tha\nhe transport of uncharged organic compounds through\nverse osmosis (RO) membrane s controled mainly by\nhe sieving mechanism (46. However, the rejection of\nhe uncharged orginie by RO/NF membranes ts often\nfaced by. physo-cherial properties of the system,\nand in the cae of fazed organics, the charge exclusion\nplays a significant cole in the rejection process [3839],\nThe sevngsnechaniam of solite rejection i dependent on\nhe reation between the sizeof sohte molecules and the\nine af the menbane pores An RO membrane as Vey\ncall molecular weight cut-off (MWCO) and lt can retain «", "ee eae\nslieins al pumimates:", "eS ee een PRO An! eee\nsthects of parameters", "", "", "" ]

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[ 9333.569058149471, 18912.885792551097, 11574.939609315828, 33317.75794568984, 19758.76496814005, 41744.481142162345, 3264.58787399999, 3219.02225550008, 63888.09348902169, 61779.35917774751, 570.2673805299855 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 4, 4, 2 ]

[ "Pesan (Ne ae os ee eee oe Pe ee en ee\npone-patella tendon bone autograft for aneircrucat ligament reconstructon offers mary theoretic advantages\nlung the potential 0 fer 2 more economical and iological alternative to screw faaton. Tis technique has\nnot been subjected to biomechanical testing. We hypothesized that a wedged bone plug fration technique\norovides equivalent tense load to failure as titanium interference screw fixation.", "Methods In 2 controlled laboratory setting, anterior cruciate ligament reconstruction wes performed in 36 bowine\nness ung bone-ptell-bone autograt. 20 knees tal fsation reled upon a standard cuboid bone boc and\neteferencescev In eght knees 8 wedge shaped bone block wth an 11 mm by 10 mm base wethout a screw\nnas used Ina further eight knees a simlar wedge th 213 mm by 10 mm base was used, Each specimen used 2\nandar 10 mm tbal tunnel The recansuctions wee tested Biomechancaly n 2 physolagis envronment\nusing an Instron machine to compare ultimate failure loads and modes of failure.", "RN Ae eyes Mae! Rel Send Clerence Letawen weds Maton ac) screw Ruption fp = (16),\nor between individual groups fnterference screw versus 11 mm versus 13 mm wedge fication) (P = 035)", "Conclusions: Tibial tunnel foation using an impacted wedge shaped Dane block in anterior cruciate ligament\nreconstruction has comparable ukimate tense strength to titanium interference screw fixation.", "The Keel chelce of gra Sec Anterior Crnciate Ligement\n‘ACL) eeconstruction controversial, however bone\npatellar tendon-bone (BPTB) autogratt is 3 well\ntablshedand appropriate option [I] The optimal frm\nof graft fixation for BDTB grat eemins unclear with 3\nsi of mio is cose aes TUL", "MBL cont and the Requcemnent 220 Fedora) ror 20\nevsion surgery, which may need supplemental bone\npalling and a tworstage procedure. Bloabsorbable\nplans have been designed to address some of thes\nsues and have been shown to have simular fixation\nrengths and clinical results [1-6 Neverthe le screw\npeakage, biocompatibility, tunnel widening and delayed\nsynoviis have been zeported 3b potential aeas of co\neen [7-10]. Serews made from allograft bone have pro\nyen more dificle to handle and more expensive but do\nhow complete bony integration at 24 months [11\ninterference screws of any sort can be associated wit\nsalt laceration, bone plug advancement and reduced\nfration etrength due to divergence.", "SE ES FECES Le ewe <a ee\nvide adequate Ublal bone block fixation. Titanium\nimplants have been used to reduce problems astocated\nwth subsequent magnetic resonance imaging (MBI) and\nfor reasons of bacormpabity. Titanium implants have\nS meniber uf dcrvtaria baciodtun latesioencs with", "Fixation without the use of any implant is appealing\nfot a number of reasons: cost may be reduced: there ate", "Charles A Willis-Owen’ , Trevor C Hearn“, Gregory C Keene’, John J Costi~", "Biomechanical testing of implant free wedge\nshaped bone block fixation for bone patellar\ntendon bone anterior cruciate ligament\nreconstruction in a bovine model", "Abstract", "Background" ]

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[ 25540.939483842463, 31159.01546648587, 10322.119730342412, 9635.995234109578, 15577.339065469336, 37843.45913725812, 16432.348803845234, 5244.44458578038, 3983.6663218331523, 41062.540899725456, 451.40478740871913, 649.6607187179325 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2 ]

[ "Background: Case reports and case senes studies suggest @ positive association between intussusception and\nceliac disease (CD).", "Methedin We contacted Sweden's 28 pathology Gepert ments and obtsined cats on 22,006 patents with\nbops-reiied CD (equal to Mash stage 3) through biopsy repos. Patents with CD were matched forage, sx\nandar period and count of residence with up to fie reference nid ftom the general population\nn= 14 522). Cases of intussusception were iSentibed rom natonvide ination, hogpta-baeed outpatient aed\nday surgery data from the Swedish Patient Register.", "Ore atios (CR) for Bane CD in patients with In uLEcepcon wae eSeirinie Using Conciions! Inglett:\nregression.", "nz i+ acaba acta ar lieth oleh el aN elo, Maal de nchie and\nsuggesting that nussuscepton was not ask ac fo ate CD (R= 1.17, 95% confidence interval Ci} =082-\nIAL ti Om for COD in Gatmoris ik ot lose ce recxida of bniumncncucdion wan 1A) BEE C1=0S-a9q:", "i CONTE, & POSLTOG Sunes SHacegc! Wek CO) wae SecA! WB SLeMtiCRy Sn cerdly Incr! FC OF\nmussuception after CD diagnosis (haar ratio= 195, 95% C= 101-37 however, thi anaes was bated on\nonly 12 caves with both CD and intussusception.", "Sareea Ee ne See Rel0Y endeiey INA Cpr TKS MOAT YE and TAO TNC Ieee Ti\nof intussusception after a dlagnosis of CD.", "Keywords: Celiac, Coeliac, Gluten, Inflammation, Intussusception, Population-based", "nut organic Chsorders such as malignancy tend to pre-\nJominate in. adults", "nlussusception is 4 condition in which a segment of in-\nestine Invaginates into another section of intestine,\nSigns and symptoms of intussusception include acute\npln nausen lethargy, vomiting and sometimes bleeding\nrom the rectum (ed cureant jell) [1 Although ints\nusception generally remits spontaneously, in numb\nof cites either contrat enema oe aurgery is needed t\nreal the disorder [2], The causes of intussusception in\n“lade infections and vaccination with rotavirus vaccine,", "ellac absense (C9) is a chronic inflammatory sma\"\netna disorder that occurs in about 1-2% ofthe ge\nzal population (34) Undiagnosed CD is characterned\npy small bowel inflammation (5) and will sometimes\nsuse small bowel wall edema [6 intestinal yp node\nwelling [7] and dysmotiy (7 but als ulers and sti\nures [8H has therfore boon suggested that untested\nCD may be inked to intussusception: a number af ese\nports and case series eubsaniate this hypothesishess\nrid] Ina recent paper fom a tertay institution\nhe US [14], 3/252 (128) of ealdren with newly dag\nposed CD had a history of intussusception compared\nwith 0.07% of the child population attending this center.", "httpo!/ www. beomeccentraLoony'1471-230%/ 12/89", "Jonas F Ludvigsson'*~ , Agneta Nordenskjéld\", Joseph A Murray” and Ola Olén'?", "A large nationwide population-based\ncase-control study of the association between\nintussusception and later celiac disease", "Abstract", "Background" ]

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[ 5915.042680741928, 23310.115319031407, 5236.99987842649, 15595.0361091448, 12711.670690885046, 7244.934380798717, 3762.0257248201524, 3497.1354890195653, 25005.523383244174, 36123.56409858726, 1478.1014467709592, 4477.561667736518, 31186.84041849748, 453.70184174999304, 655.0555694299983 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2 ]

[ "ets ae ee eee Cee eee a ee: We, ee\nronda a karape nthe 19 Hower, ie markt clap\now in pr fo eferemnet of sflaein regulations sn Earp (sh\nlr in} imrove knowtadge of he elegy of afta con\nninainn in Za may tee manage! opin (ay\n\n—.", "mekr inner pur Raies ahoreran Aer ehrg—t", "Miiataxin contamination is caused by crop infection by one or more\nexes ei Te pre ri\ndaring op development nd wars and hamid afer cop ma\nerin aor harvest (ct) ao Inne Ctl 207) Th apc\nmat notorious fr cop contamination ae Aeris fl (rds\nnamed na Sy nb aston) od Sy ath Bad a\neins Cty tn 208 Pao a 2010, At pradacs a\nen med onthe bef let mominagy (Oy 8)\nmerhonype fat pede fe lage slr avrge ter»\n{00 ym) and § maroc fng pee sumo al sees\narea ameter © lbp (exh, 19), Pang hs mol\nrojucmly proce Inge guns of ato Meer pyle\nte sulies gg $ bphalype alt podues af ata\nrel sper 2) A fone § si; b) Latha Mtns Pang\nAPY 8 tht vetlel ae dd many desi\nenya rabies 2007) he named aon yo os Wes Ae\nCoy sl Cael, 190) an €) Amilo (Fos\nApt ety oi ta\nmparance of specie etal sens ay try fom oe ep\nother (styl. i reguecer Wf aati rodeo\nnner tat may caer tone iio ping ene\nvce contamination of sonata fat ad rant (Bayes", "Zann, conpeions of pera ec Fa erm 0\nharacerard abd rte fo Aer sein Free mon\nstl wap pre wa an ps\nsei ton Free neo es pe", "cnc mein an hate agroeclgies esate I, a\nyee a 1095). Agoeaogy the ober mo wh ee\neal temperate, 30-33\" (nyo es, 105). Agroclgy I\nci a 1 vera el eerie Agee\nee Gn", "Maize (a = 250) and sromnnnat (a © 162) samples from 2 peewioms\nend (fachapla a 2017) epreseting 27 asics na a te\nrons of Zambia (st 2} wee led te care\nmuy. In aon, 20 sls were sampled fom aise Sl\nf= 10) and fom soca areas (= 6D) in 1 dai co\nring al thee sponges (1). By, a let lain\nfar were sapien each dare. Thee conpote sal ane\n00175 ele sie fom ne lly coping sal a\npeta te rdom locaton in each fel deh of 2m\nCony, 1997. each agroclgy, cop ad sal samples were eal", "Destnibution of feng of Asergiiss eectoon Flari on meen .", "\"Roa dae aoe amore un CF tee gwar al Ve awed et cach h(a ow eh ie\nCa, nissc Aoi unen tier ests ead salp eer a", "", "", "2.1. Study area", "2.2. Sampling", "" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 4, 2, 2, 2, 2 ]

[ "betas weighing. Selected samples were frenen af -20°C\nsad lyophilized for 48h.", "ee oe ee eee Se peer ae ey\nJetermine both extraction efficieney and economics. A\n130 ratio of defatted snal to slvent, and an extraction\nime of 120 min were ulled in thle study, as recom\nmended by Disa etal. (2005). To avoid protein pee\ntution and achieve the naximum protein extraction,\nImportant to avoid pH near the solectrie poi o\npoten. Based on the Merture, the holetie precipi\nlon of B juncea protein has been found to ect a\napproximately pH 6.0 (Moure etal. 2006). Therefore,\nlaine conditions (pH > 7.0) were chosen to study pro\nin extraction. Ground defatted meal (50 g) was mixed\nwith 150 ml of centrifuged TS. The pH ofthe system\nvas adjusted to pH 76-104 using allalinegheerol fom\nbiodiesel plant (-10% KOH) of 10 N'HCL NaCl was\nised to adjust the lone strength ofthe ceatuged TS.\nThe concentrations of NaCl ranged from 3.4 x 10? M\n@ 1.2 M. The pl and salt concentration employed ae\nscovided in Table 1.", "The mastand meql-T'S mtxtuce wns stierecl continw-\nnul for 2h at room temperature (250). Ale sing\nhe solution was centfaged at 10,00 zp for 10 mn\n14°C to emove suspended solid. The supernatant was\nreexe-dred, alter which the protein content of the\necre-dried protein ofthe undissolved solids were ana\n\naed, The moisture content of the undissolved solid\nwas also determined, The conditions tht provided the\nmaximum protein extraction efficiency in this study\n(NaCI concentration of LO M and pH 100) were used\nsubsequent studies of the effets of TS constituent\non proeln exteaction eiciency. A conta extraction\nvith allaline NaCl solution (L0 M NaCl i detonized\nwater, pH 10.0), hereafter termed NaCl solution, was\nronducted. The quality of the protein products froma the\nsatel eull'TE cracls war comeinal.", "esonance and high pectocmance liquid chremahogrgey\n(HDLC) were ullized to determine the content o\nnganic compounds including lon chromatography and\nductvely coupled plasma mass spectroscopy (ICP-MS)\nprovided 2 detailed analysis of inorganic constituents", "ache 2 eouaneD apichdinica te rindi thane pace iae ee\nRatanapariyanuch et al. (2011). Nuclear magnetic", "a ee eS Pee 22 ee een poet\nsuse for protein extraction from mustard mea. Ce\nraged TS was fltered though a 3,000 MWCO rege\nrated cellulose membrane (Milipore Corp, Bedford,\nMA, USA) asin a sted ultrafiltration cell (lipo\nCorp, Bediord, MA, USA), running at 55 pst with\neae cate of 200 rpm. A salaton of NACL (1.0 M and\nDH of 100) was selected to obtain the highest protein\netaction elcency (based on results fom the previous\nexperiment above). Protein was extracted as described\nabove. The supernatant from the centefaged protein\nolution was dalyaed using Spectra/Por moleular-por\nbus membrase tubing 6.500 MWCO, Speceum Labora\njories Ine, Rancho Dominguez, CA, USA) at a\nsupernatant to deionized distilled water rato of 1:00.\nWater exchange with fresh deintaed water ws repeated\nheee times a day untl the conductivity of permeate\nwater was qual Lo that of deionised distiled water fe\nsh of dali. The protein solution obtained by dials\nvas freeze deed. Freeze-dred protein and undissolved\nlids were analyzed for protein content and the moist\nie content of undieslved solide was also determined\nProtein products from TS and NaCl extraction were\npooled according to extraction solution type, and then\ninalyzed to determine the molecular weight, peptide\nsequence, amino acid composition, digestibily, and\nvine availability of the proteins.", "Moleculor weights of the exteacted proteins wece Geter:\nmined by electrophoresis separation using sodium dode\nyl sulfate-polyscrylamide gel eleceophoresis (SDS.\n\nPAGE) (Laem, 1970). Ten micrograms of protein\nfom TS or NaCl extraction and 5.0 yg of SeeBlue™\npus? Pre-Stained Standard (Invitrogen, Calsbad, CA\nUSA) with a eange of 250 KDa were applied onto 86\nom 68 om Ready Gels (Tee HCL 4-158, 10 wel, Bio\ntad Laboratories, Hezcles, CA, USA). Each ofthe pro\nins products was mined at: rato with loading bu\nfer (10 M Tris HCI, pH 68, containing 20% glyero\n10% SDS, 0.4% bromophenol blue), and heated om 3\nGene Amp PCR System 9700 (Applied Biosystems, Fos\ner City, CA, USA) at 95°C for 3 min. The Min PRO-\nTEAN ' cel (Bio-Rad Laboratories, Hercules, CA, USA)\nvas fled with cunning buler (Tes base 3.028 gy\n\n‘ine 14414 g/l, SDS 1.0 gil) adjusted pH to #3, and\nSlectrophoresia was perlotmed for 30 min at 50 V. The", "Ee eee eee Uae ae\nfy the effect of pt and alt (Nall concentration on\nite eatin emetanas", "", "", "The effects of pri and salt on protein extraction", "Thin stillage composition", "Protein extraction efficiency", "Molecular weight" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 4, 2, 2, 2, 2 ]

[ "Nee ee eas csumates ot materna’ ut not\nteal ond ate ight han tose bad on\nrm erogapic nd heh uve OFS). We\nesiat th canis oping of peal\ndear prtenbeprayrosd she ert polara-anl", "———E———————e ee\nnatal phan pele hoe rounds 3\naspect oie ers in Manca (1088—\nZO) weh esate tor OHS saveys and UNAIDS\nnal pojcar. We vested to constr of\npring of paral sui staus acss te tree\nound and carpaed etna fds mol fom\nhe phan ta th dec estimates Hom canoer.\nalowp ofa goer pepubn cor. Que\nFes coiscind a peeie emis tet hearin,", "ee\npeeing n Zimboe Maters repre as deceased i\noutdo the Manaand suvey were more ly an\nters tobe rp se nos or [333%\n3.48). Te pte vs mat apart erg aug\nhier. The quate ergs sues that aster,\nret sonst nape chen 35 he rata\ncrm", "eee\nening ol ster pats 2s natal pnts. This\npea ob prea carmen ang fester mates\ncou party ela he dcop bates\nmabe! mada ad ONS estate of metal\nvmhenhood.", "minect emiparical’ estimation of orphan numbers i\nmany developing counties comes from demo\nphic snd health surveys (DHS). These\nptionsl cotraectonal, household surveys con\nJute evry 4-8 years, Concomitantly, UNAIDS\nUNICEF, USAID and the US Census Buea bave\nlevdoped matkematal models (Spectum) t\npodice demopphic projections caternd\nternal and unl orplan'revlenee—both all\nruse and orphans apa rect of AIDS i\ntes expetecing nor HIV epi, bee\nevens iT HIV pnbakeee#", "NAEIONS POPUAEON MIVISION'S POPUAHON projec:\ntons could have caused an overestimate ol\natcral orphans, Aleratvey, the howsbol\nsrveys mthodclogy could have ed to 4 systema\ntic bie in the reperving of maternal orphans.", "rphans found that matersl orphan estimate:\nfom Spectr vwee agian higher this\nhoe fe DHS\" This ence was wrt\national HIV prevalence among counties sub\nchar Alea sgting tht the dferenc\nvere not caused by nimi about” AD)\nJonha The soumplont abut uedyng ad\nsat cid casa Gpeenne one ca eed", "UN Ropulstion Drsion mode. fe tables to\nroduc revised estimates of orphans” However\nese new mathe mod nl nto\nhe prevalence of maternal crphashood when\ncompared to the DHS estimates sors sever\nnibSaharan Aft counts (gD, although the\ndffeence isles pronounced than for the 201\neimates* The model peictons fhe pevlnc\nof paternal orphaoed compute well th the\nrc aaiene", "1 pnan esta are 2'30 used fo indirect'y estimate\nadult morality in counties without vital eita\nron gytems* This mcthod can. give tase\nmtinates if thre is udereparing f eileen\nhone parents ded when they tere young,\nfeats of reports being based nthe trv\natus of thei ving fate! paentthe “adoption\nsec\" Str mothers oe more tke than\nfone lathes to be marepored as natural rents\nhis could pay expan the lacepancy bate\nthe model tad DAS eatinates of tera span\nonl", "Manicland, Zimbabwe, to vestigate Bas i the\nporing of neal id gated\nCale maths were walt expe pie\nSe ect tet", "Vemograpnc an’ eat Surveys sare\nvations, costetionsl, household surveys. I\ntach sary, a sample anging ro 3800 #0 900\nRowahold is seloie in cach county using\ntrnifed random sample of chuner that\nchaen to be representative of urban snd ral\nteat DHS have fren conduit in Zinkabve in\n1963, 194,199 and 2008.6\" A quertionnaie\ncompleted foreach housed in wich al ind\ndul ceaent in the housed a lated. or each\nchild under 18 yen: (20086) or under 18 yer\n(968-99) the gueston “ls NAME’ biclopes\nmoterEather alive?” is asked. A chld wn deine\nira pateral orphan if ther father had ded\nmpdes ofthe survival sats of thir ncthen—\nhats the definition of ptermal orphans ince\nseuble arphans Atel’ qobaibion ec emerseaal", "meee\nieee", "aon pide, ps\ncee\na\nee\nergs\nrai", "Discrepancies between UN models and DHS survey\nestimates of maternal orphan prevalence: insights\nfrom analyses of survey data from Zimbabwe", "ABSTRACT", "METHUUS", "Demeograpmc and health surveys" ]

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[ "materia’s at 60% and’ 63%. respectivey. naar\nce betnen the opal properties of SODFIA TH. FB whether\nin sclution or encavaulshed crate", "ee eee fee eee a eee eee ee\nost decal othe vlan state mearuement tment\nFpe th Furthernwe the ro open cde «dein\nbe broadening ofthe band wi 4 mam 3 65 am apd\nshighenergy shoulder t 547 nm. This ndcatve fs small\ngre of spreaton,altiough the smal shift of the emission\natraam (fat 15 ma) when pared fe he scion sn\ncolt i's eu of daa fis es healing como\n\nsation and separation ofthe Buoropores bythe ier matic\nheal ercace for tha comet Em te plorcoer\n\nsence quantum yielie (PLQY) of the solution and encapeulated", "oO ener Study the color conversion capaniines\nBODFAATHLEB was integrated withthe transparent CHDV\nyer and deposited on a flly-packaged bse LED. After cxtng\nhe oanie mater mtr tare formed slid dome on op\nofthe LED chip There blue LED andthe sme LED enesp\n\nted withthe npaie material (1 (wo) BODFATH FB wth\n1% PAG) ae shown in Figure 2s sd crespecve. Ar an\nhe seen in Figure 2c the entire cup, containitg the LED with", "Figure 2. 2-d) Photographs of the {a,b} bare blue LED and {cd} the same LED encapsulated with the organic material (195 (w/¥) [BODFUTRLFG with\nTPAC) wil the LED fa) swtched of snd fo) unde soward cent of 75 mA e) EL spec of he lu LED before and afer encapeltion\nmvt aene wel canes Te pee wromalsd eth He LED peak testy Cham degay (E128) sewing\nSS Aree crite Gaee lil hshmnreeeis as ecaaes looms toadenitend tasters ehavameeea uh Lgkabeaaet ariealae Eni Eee naeenon", "Table 1. Summary of the propertes of (BODFluTh), FB.", "", "fa) 9 eer iy +++ blueLED 7]\n5 —whteLeD |\ngost | 4\nA pr | {\nSoa | 4\ni Boal |\nBoo Lut =~\n2°\" G90 500 600700 800\nWavelength (xm)\nTam\n9 @\neV\nos\noa |\n02\n00\n0002 04 06 08" ]

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[ 6652.766854068963, 29133.988696800196, 21059.49332629051, 18797.370657096617, 1939.6713505251028, 26156.803619100006, 180314.532864 ]

[ 1, 1, 1, 1, 1, 4, 5 ]

[ "Backgroune: The perfusion Index, denver from the pulse cximeter signal, seems to be an accurate preciictor for\nrigh ilpess seventy in newbs. The aim of ths study was to detemne the persion inex values of cnically\nsnd hemodynamically stable preterm newborns in the fist week of if.", "So Perea imeer Neveplnn Pigg Wee bes eae, Mn) Wee eae Wee ee ever ee 0 20 Pee\nrenborns. The state of heath was asessed according to crcl and behaviour evaluation and othe Score fo\nNeorta) Acute Prosiology,", "Results: The medianfinterquarile range) periusion incex values were: 0:590.5) on the first, 1.2(1.0) on the thine, ane\n1.3109) on the seventh day, with a significant increase between the fist and the third day.", "Conclusions: Peslusion index psoved to be an ssely applicable, non-inuesve method for monkoring Say\npostnatal changes in peripheral persion ts tend dung the fst week of fe sugges that ts clinical apoieati\nauld take age nto secount Furtarstudes are naeded to obtain reference perfson index values om a ger\nample of preterm newborns to identiy specific gestational age-related cutoft values for ness and to test the\nwe ofl perfusion bude: in snorihotiey crticaly i Ceoretes.", "Newhecns admitted te neonatal intensive care malts\n(NICU), and in particular preterm newborns are at high\nink for morbidity and mortality during the st week of\nfe because of respiratory dstress and bronchopulmonary\nspas, apnea and bradyeard, necrotizing entercolt,\natraventicular hemorthage and periventricular akon\ncfg dite, ypogiycenia, hyperblainri\nsnd neonatal sepsis [1]. Most ofthese neonatal morbid\nes, and in particular severe neonatal sepals, which\nscouts for 1% - 27% of NICU admissions [2-4], are\noften ssoited with high mortality eates. Early lagna\nnf these neonatal complications fepreseas one a the\ns ssleat alisames to sncnuialeehts", "mopectedl be aedlect resi-tiene changes in peripheral blood\nDow [6:7] and to Wently inadequate peripheral pela\nion in critically ill newboras. In particular, low\nvalues have been demonstrated to bean acura pee\ndctor for high illness severity in newborns (8) The\nalse oximeter an easly applicable, nom-invasve dag\nposte toa for eal screening of peraatal inflammatory\nlveatestuch as subciniel chorioamnioniis [9-11\nReference Pl values in newborns have been recently\npublished [12]. However, only few literature data on\nPI values in preterm neonates are available.", "Je She lateay Tearee Uae PTEe-Chunyetce Haw DeCnine #\nital NICU instrument [5]. The perfusion index (PD),\nlerived from the pulse oximeter signal, has been", "SE ee ee ee eee ee\nally and hemodynamically stable preterm newborns in\nhe Fst week of ie as a prelude to the clita applica\nnarreepeal", "REET Geter: DEW ETnY Aang Taare Raley UE\nNeonatal Care Unit (Regia Margherita Children's Hos\nvital, Turin, Italy) were recruited consecutively for this", "Francesco Cresi’ , Emanuela Pelle’, Roberto Calabrese“, Luciana Costa’, Daniela Farinasso , Leandra Silvestro’", "Perfusion index variations in clinically and\nhemodynamically stable preterm newborns in the\nfirst week of life", "Abstract", "Background", "Methods", "" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 2 ]

[ "a ae\nparnacogal statis which ve netophs to undergo propane ell death (apoto) have\nen chw foie thereon of eaten Bathe ya dependet lier\nCok savin atic aha rane pop th\nses he we dere he en, ated nverigatin othe lg peta esa\nces fd cepa rained by ana Recotine wh we la NO doa mas\nCorpor 2 Su 0 x sysbsned cmpaunds wre tee pte po ssi en\nSy promi an tol pps ae hah camped Band wed\npunk eva ft tyres NO (a ND sao} a ter NO share se\nfe tt ae pogo he risers tha\nNae nara ene ae ree ccreitioe, These dans show teat novel -", "—", "ney Se ee eee eee cee\nlamatian can occur Apopttlc granaoytes ae Fp te\noved fom inflammatory ses by macrophage pays th\nomsequa!danpening ofsfamnation “Prevails was ele\nhaatereemovatebeesus ofthe the reslton\nation was merely a pase process secondary othe catabolism\ninfantry editors More recently a nceaing ube\nan active ces involving Several cele prceses includ\npops ad phagocyte cesranc of apoptotic cell tht cab\nmodulated by eadogenass specalieed provesoing Medta\nSPh, These include eyeopentanone prostaglandins. oxi\nsaving, proteclasoeuoprtetins, and areas” Whe\nation eslution als, the granulocytes can de by aero\nalternative fom cll death that saves tpt of cla\netabrane wih consequent reise of sameeyte hist Co\nents the extacelar ne, Thiscan pepe nflsmmate\neading to ehnicy, wih dysregulated granloyte appt\ningen the pathogenic a seera! human larly\nseats The developmen’ of pharmacological agents or steatee\npablo selectively incre sing rane apoptosis potent\nmer therapmunie tecatney te odace ‘othe cama and’ chrenks", "Tndiamenation is the ost response 00 tissue inpury or iniecrion.\nsed at estoring damaged ste o Romeo Flowing\ney of endogenous medatr ae eased which edt\ndial igus of olacimation: bea, redness swag ad pa\nVscuctve ames, ozo eyes, ctoine, is. eas\nois elting an Mint system products, ic nie (NO)\nnd eacie agen species (ROS). are re a the portant med\nors ivaved Daring a episedef acute lamsnation compe\ntts aleventsocusiacutngtheserltent leukacys oth\nlage sue Graulsyes which eompes neuopiscsio\nhls and basops rete fist eukooyer abe recrued lowe\nby monecyejmarophage and ympacte nfiain ino the i\nede Ti cue bf aca nt\nmul\" ter emovl othe sein ifanatery ils\ns canned thar guamsiocytes dle by opeeanaie. a proatunmad and", "* Conrespomdiing aathor. Tel: +39 (0}11 G707ESO: fax: +39 (0)11 G7O72B6.", "", "", "Mt Contes far fgflosustatiinn ttoseontth hua’ bleh esenunch fmsertuve, Unsicertity uf tebiahuneh Adeuien! Se act. tel\nAEC fain Rah, Qe Mal carh ee, Lea of rh Mel cho Eb 6 Une ig\nDae eee eee are Seton Seren Sis Sadaeetye Sf iaayh nl beak Sieg ST AE tet es", "Gabriele Montanaro *, Massimo Bertinaria*, Barbara Rolando’, Roberta Fruttero**,\nChristopher D. Lucas®, David A. Dorward”, Adriano G. Rossi®, lan L. Megson‘, Alberto Gasco*", "Novel R-roscovitine NO-donor hybrid compounds as potential\npro-resolution of inflammation agents", "", "" ]

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[ 49845.170122966636, 1783.0845117793942, 57615.58496977389, 41738.409965386614, 2068.328561253671, 626.7986466583679, 738.3693378163734, 10522.524859860074, 11800.09761988584, 11116.962218859291, 718.271987365355, 589.2780872398725 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2 ]

[ "1 0.98-1.42) (Fig. 2). A higher CT score was signifi-\nly asocisted with depron satay expliing\n2% of variame (yosi2e10-™), Multiplicative\nications ere fouel bese polygenic mes fx\nMDD and CT (fig. 2) The interaction at py <0\nmplined 19% of variance in the phenotype ened wa\ngnficant afer mliple ting conection (p= 0.002}\nThere wat an inverse misocstion between ner\nscion and MDD stats (OR=096, 95% CI 091-098)\nTo wnulze these el, nections were lated be\nvice clegoris of CT (none, mid, modersesevers)\nind PRS standardized to mean snd so. 1, Ping\nog crt of depen by pgm sore foreach\nCT eaegory a the p value tesold with mos sii\nant interaction (p< O18; p= DAK) allows vse\nfon of the rolls (Fg. 3) For invite who ha\nnot experienced CF, a higher PRS for MDD was a0\nned with» higher sso the disorder (Fig. black\nine). Individuals in the mild CT category were at an", "RRS CIP Se Sn eenee ae Ue et SED ane sack ir\nlepedetly oftheir genetic Habit Gritd-gey le)\nThowe who had expecenced) moderstaevere Cl\nwere mt deprene cans but resesingly the id\nisha ighest ik in hs category bad ower PRS\nhan average (Fg. & light grey ln), Thee were\nteractions beeen PRS and CT under adlve mod\nas (online Supplementary cnateril),", "SS, Sees wees Epes | be\npreen PRS for MDD and mumber of SLE. Signfcan\norlations wer found within the MDD cases spe\nlly weit dependent (py <000%; p=0.002) and not\nJependentSLEs (online Supplementary mater). Ne\nigrifcet cormetions were Fouad between polygen\ncore and CT score inthe RADIANT UK sample (ow\nine Supplementary exataria, Ae te ioucecticn", "Fig. 2. Polygenic risk scones (PRS) for major depressive disorder and multiplicative imeraction with childhood trauma (CT)\ndt ped epson inthe RADIANT UX sample The ye eae Nagra eae of\nnan ele On the ni ine ae hele on single cee pyro ne dace\nsiaos cos tad te bt pusp eles ceil \"9-19 SNE en belear Cpe ome Gen ole eee", "—\n* = P,<0,0001\n= P,<0.001\n= P,<0.01\n= Pr <0.05\n7 = P04\n0.015 = Pp<02\n“ © Pr<03\n= © Pr<0.4\n3 PL<05\n2\ngoor0\nR\n0.005\n0.000\n7 a", "Gene-enviromnent correlations" ]

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[ 49084.35284852376, 19641.760310429614, 20553.941642152146, 18200.423778784927, 159565.71559334343, 1386.8380726826144 ]

[ 1, 1, 1, 1, 5, 2 ]

[ "ee ee en ee\nNy (ra SAL THM? cells could give rise to NY -expessng Teel\nnT cls ound expression DN ces could aa", "EA\nted population confirmed ytokine uty ofthe sorted el\naso} The THI TB sed Tels gonested in his mane\nete then e-stimulted ia the presence or abvence of 12501\nfr two diye Ia vehicle-treated reatinlated populations,\nserved plasticity of phenstype herween TRY, Th171 and Th", "aera eae eee reece eee ey\nnT cals pro-commuicted tent? and TRI Enanotypes ruapoctiaty,", "sresietesh adi mitsteneay meabnmemelsncl<us8 ta Reogpeneaaes priocepacacets SoeERNL a. LRP) epee bf otipeepmeeten ar leturiemt'Sc oe eoey emcee ators\nte wit aga noncancer sce 125, 2) Fyfe ening Ny 2 Gui a\nnm near sa REN, 1a) oe ya) a of LanyDy oo ye\nemer enon merry ce hy recy ot pot ce umes cau condone lower Geency tt of 0.015 ws eng tr thee cates", "A. JL17 b.\n\n3 a go, 7\n\nBa = ee]\n\niq + fas\n\njie 3 Pot =\noe i\n\nida Ea i\n\nit qE ie.\n\nwo ae ‘Naive Memory\nee is\n\npi a\n\nBag Te eS\n\neas ie\nCTLAA 4 CTLA-4\n\noe) eee a\n\nial “Zt hit\n\net! =" ]

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[ 8942.364872333594, 15613.813737226184, 5072.745732525131, 26948.791422252543, 191745.58888700002 ]

[ 1, 1, 1, 1, 5 ]

[ "Wale beret As, Thergiomy, cle-seR Ag forms munch mere enengeticnly stable Gaplenes\nvith thes targets than tran-asRNAs, General, ci-asRNAs are associated with mobile\ngenetic elements such as plasmids, phages and transposons. They contribute significant\no the regulation of plasmid copy suber, conjugation, phage Me cyle and uanspostion,\nSeveral anti-toxicity activities have also been reported for some cis aaRNAS [1, 10}", "APE REAE were (tee Cetecied, eo Vicceees Liven De overpere and Mnaby x Cary\nses According to thir relative orientation and degre of overlap they ae clase\nno 3 categories; head-to-head (3° to 5), ta-to-tal (3 to 3) and fully overlapping\nTallto-ailorentation seems to be the most common type. Overlapping traneript\nmight comprise two protea-encoding genes, one proten-encoding and one non\nencoding gene, or two non-encoding transcripts [11]", "Fig. 1 Gene slencing by natural arnsense FINAS in bacteria. &\\ = Ceranmsense Riis (clash) ate encoded\nhap eer l career eae AB Tera Sts fra ae ce\nttn pert to wae rf re-post gue an RIAs\ni ae arg a Gey ner carte star et\nrv rae the ere ened eter i sae ian ahem\nSr eee ee eC oran neta anti tae te nent eee:", "Table 1 Cifferentiation of cis- and rrans-asiNAs", "Dek prc tera gue Dig inp etn ths\n\niene ath ee ee ‘Spey ere age See\n\nage ti iN Tage ples ge ant tm omen\n\nYost Fg rg sal hue sae\nCarpi ae istry,", "a\nAeneas\nSNe\nmou ow yea\nae pemmen t" ]

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[ 23875.156482160557, 27278.73612263985, 19775.613109840313, 1748.8249136013328, 43005.71775186306, 91842.58128100999 ]

[ 1, 1, 1, 1, 4, 5 ]

[ "G)roprcesins secreted inl pasene fom T cee infected’ win humnen Enmuncceency vive (rN) leseng nectar\nmay provide night ito undersandng the host espense to HW ifection in ia Ghycoproteomis, which valutes\nhelevel ofthe gheopreteome, remains a novel approach to study ths het esperse to HV. n de to idenay|\nnuma ghcoprotens secreted frm T calls wth intent HV ifection, the medum from cuted HA repcaton\ncompetent Teel va cerpaed withthe medium fam cued parental A201 cals ia oid phase extraction of\nalyeopepides (SPE) and high-performance quid chrematography tandem mass specromeny (HPLC MSM) Using\nhese methods, 59 human glycoproteins wee iertfed as having soncaty deren abundance levels beeen the\nmela fom these te cll ines. The relevance of these 59 pratense HV infection in vio was assessed in plasma fom\nHW\" and HV subjects. Comparson between T cell and plasma reveled that sc alycoproens(galectin-binding\nprot, Laeectn neagenn adenosine desminase CECRI, COS ign and phosphalp tans poten) vere\noneal elated inthe HV\" T ces and plasma sures These frings sugges thatthe espense fT cl harbering\nlatent HV infection contbuted in par, to the ghcopraten changes in HV\" plasma, These pretens once valde,\ncould provide insight into host HV interaction.", "Keywords: Glycoproteomics, SPEG, HIV, T cells, Medium, Plasma", "SETTLER, GURGROES, PCOGRAES, SERINE, POOCICTION Smt\nhe elucidation of the pathogenesis of these disease,\nproteomic studies have demonstrated thei applicability\na high throughput fashion [9-11] However the urgent\nned for the identiication of biomarkers of HIV and is\nrelated diseases remains unmet [8", "ny 201 there were approximately 53 million indwidua’s\nving with HIV [Un the same yea, tis estiated tha\nhare were approximately 25 milion new infections and\n17 million AIDS elated deaths [1] Although tremen-\nJous efforts have been devoted to prevent HIV transmis\non, to date, no effective HIV vaccine is aval [2\nastead, highly active atizetroval therapy (HAART) is\noutiney used to teat patients infected with HIV and\nhas bee shown tobe elective inthe prevention of HIV\nvansmission [3], HAART has greatly improved the ie\npan and quality of feof the HIV’ infected population\n4. Howeve, HIV related nese such as neurodegen\nitive daeass, cancers, and bacterial infections have\ninerged a8 important lrues in HIV\" patients [5-4]. To\nddentify proteins in a complex sample for the (eatly)", "‘HIV Ie a dentiviras which belangs to the retrovirus\naly (12). 1 priearly nfects immune ells containing\nCDs veceptors, such as helper T cll, dendrite cll\n(DC) and macrophages, and establishes latent infection\nthese call [13] An inevitable step in the via epics\nson cele the iteration of vl DNA into the T cel\ngenome pir to either latent infection ot active produc\nnon of ions [14]. The infection of the immune cll,\nwhich reside in the blood and dining lymph tissues,\nlls inthe atypia secretion and shedding of disease\nlated proteins ito the peripheral blood [15]. Thus, the\npod of patients infected with HIV i consdered tobe an\nexcellent source to Kentify proteins that are associated", "Soa Chdeare Strat, CRON Ronen 3 nhO Galtimewe MOTI, USA", "Weiming Yang, Han-Ving Zhou, Li Chen, Minghui Ao, Shisheng Sun, Paul Aiyetan, Antoine Simmons,\nHui Zhang’ and Jay Brooks Jackson", "Glycoproteomic analysis identifies human\nglycoproteins secreted from HIV latently infected\nT cells and reveals their presence in HIV* plasma", "Abstract", "introduction" ]

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[ 1, 1, 1, 1, 1, 1, 1, 2, 2, 2 ]

[ "Oe ee ee eo\nnary at seas (CAD the wal A ppd\nsed, os Sectial sey was canfutod et 3143\nfs aged 40 years fo 12 ano select\nmms Krah, Flin gat fon smog\nven of mate CAD kat (betes, ype\non, besty ajiitema) tan men. etnis CAD\nitr and wave EC) was mare pret me\nhan women (61% vs 40% p = 00 nearest,\nshoe aré major ES charges ware ie 5\neu n women asin rn 2.05 vs 158%, and\n7 vs 108%; pDOOT fer each spiny\nmenses of CAD wer stn pede by te\ntaal soma, us hat ad ta aca rte\nyet poder of £05 abearmatosn werent it\nnen, Ta ngs indicate tee in ve missed\nats tn Plan may have uso CAD.\nWomen ore at groatar rak than man.", "irial registration number: WU) lUs2/5/ 6", "See ee ee aye ne Oe ee ees\nsseptbtes to coronary artery disease (CAD)\nhe wor\" andi ie terfoe unsurpeiing ta\nCAD i now the leading esse of death nthe ldo\nseisstan eoeadtneee®", "ee ee\nsuggests a almost 25d a inthe prevalence 0\nCAD in two decades fron 3.6% in the 19st\n7% in the 1990s in people aged 38 years in\ntan Indin® With increasing utarisaton tn the\nuhcontinen, CAD presence can only continu\nore, and ths undeines the ned Yo undertone\nks and deterninants of ase inthis poplin\nS ebscn pavathe ence", "DIAGNOSES, ancl Pedr ssociabions Wally Fisk factors,\nhave not been formally sted in ltge population\nfmplet. fom the lndo-Pskistan_scontinent,\ncisties sha chsies ok domaken Guede", "EEE\nzuopean populations te burden of erase\nstra factor sn indo Asan, such a byperten\nion, diabetes, dyipdsemia,ckesty, ilu\neral obesty, and pyscl inact, ae lea\nutenti atria women th a ea\nronespondinpy the ender difesence im pele\nCAD my slio be attenuated even abled\nado-Anans, depending upon the diagnose x\ncra employed\" Population based thes ree\nsabsed, noninvasive memures of CAD\" Is\nfvcopingcoustcy, in pater doctor\nay be based by perder ferences im healthcare\neling behavioural and gnostic prie\nces On theater hand, ECG eterna ough\nbof ee prageat iacancs in wemen\nHowever, gender dllernces in prevalent CAD\neucac to naihie non ioeaner cata de", "pendes differences inthe prevalence of CAD using\nnon‘aasve enter, and their asocston ith\ntandovecala ek fcr a poplaon trp\nfrom Karachi, Pakistan,", "committee at the Aga Khan University, Pakistan.", "BO eee ee ee.\nss of 3. population based sample studied fo\nrerun to 4 dsr candoried taal\ntratges to contre hypertasaes (Teal rept\nvom tumber NCTUISI7S74) All subjects aged\nyea ae able to ge thir consent Wer\nclude nthe study. Posy mall patients, tow\nmentaly incompetent snd unable to ge consent\nor patents who had sown advanced ler\nLid‘ey failure or paegnancy were enchaded.", "ity of Karachi into SOD custers each of about 250\nhoticholds On average, ach Kowseeld contin\nven peopl, 20% of whom are aged 40 years\nAbou 85% of ll ster (200) ae in the low\nacome pop seghbourhcods (eveage howchol\ncome les thn $12/month) and ere mapped\nato 12 geagagbcally coatgueus areas of 50\ncaters each Gos later wa randomly selected\n(computer seated) foe ach ars fr elson\nnthe study. Acenms was dove, anda iting of al\npeople fom all hoses inthe selected seas\nmale", "ene th alana Sahin ony tration smen cn\nvst to the selected Subjects and ted them to\npertpate in the ated Al subjects vee eal\ncated by 3 sigrouly tasted Bld tear compas\nng Feld worker, tures and techn) fe\ncaning informed consent, The eration\ncluded the flowing (2) story and pis\ncamination; (b) questionnaire dealing smoking\nsatus food fegueney questionnaire sod the\nLeste factor, slfveprted dctor diagnos o\nbert dese, the World Health Organisation Ros\nqoetnrmare* for angina, aed the international\nPiya activity quesionnaie;() asst\nSd coe wits ccamamied cooeined daves", "DTH dar, Cncal\ncry ea Soe\nIne i a\ncrs Psa te", "aeaamen al tema\nnn Crm\ncy ei nl", "1H Jafar,’* 2 Qadri,’ N Chaturvedi-", "Coronary artery disease epidemic in Pakistan: more\nelectrocardiographic evidence of ischaemia in\nwomen than in men", "ABSTRACT", "METHUUS", "Study design", "camping details" ]

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[ "PUR ERAOE GROUSE WAH a palced p-tvet. Bor thls wala\njroup analysis, we also calulated the effect size (ES)\n(Cohen's a. For all analyses, P< 0.05 was considered\ngnfcant. In analyses involving Bonferrons adjustment,\nPc DOI? wa considered significant. All statistical cal\nculations were performed using Graphpad Prisms\n(GraphPad Sontware Inc, California, USA). The effect\nize (ES) caleulation was performed using a web\nesource hitp|/wwwacesedu/~facultylbecker/_ All\nvalues are mean + SD, unless otherwise stated.", "ar re ee el ha AE 2) ane Soe\n£15 1075 = 19 mM (P « 0.008), respectively (Table\n). The NpPROCHO beverage was associated with\nhigher BUN values after 120 min of cycling than the\nCHO beverage (P < 0.017), an effect that was not quite\nound for the PROCHO beverage (P = 0.03) (Table 3).\nNo difference was found between PROCHO and\nNpPROCHO beverages (P = 0.44).", "During the prolonged’ cycling the alleles were exercis-\nng a€ 62 2 1% 0f VOanr Ingestion of the thee supple\nments CHO, PROCHO, and NpPROCHO did ot\nprovide ferences in HR, VO, o# RER at 30 eu, 60\nin 90 mia, 120 nin ofthe prolonged submasima\n‘cling (Table 2). Nor did the the beverages result i\nferences in blood glucose and blood lactate (Table 3)\nbin RPE (mean vals eanging fom 1.1 to 13.5 across\nme points and supplements during the prolonged\nclings dats not shown. The supplements dl, howeve,\naul in diferences inthe concentration pote of BUN,\nWhile ingestion of CHO dd not result in changes i\nBUN levels between baseline (63 = 1.5 mM) and 120\nmin (6:7 = LS mM) of steady sate cycling, ingestion of\nPROCHO and NpPROCHO resulted in changes frorn", "wiean power output during the >-min mean-power test\nwas not diferent between beverages: CHO 339 = 42,W\n5:4 = 05 Wks\"), PROCHO 390 » 31 W (5.3 = 05\nWig) and NpPROCHO 399 = 33 W (54 = 03 Wg\n) (P = 029, Figure 2). No diferences were found i\nconral parameters RPE and blood lactate between be\nrages ax sampled directly afer the S-min tean-power\nst (data not shown). However, a negative correlation\nwas found between performance inthe NpPROCHO 5:\nmi fmenn-power test and athletic performance level\nmeasured asa performance factor, as developed in\nTable 1 (Pearson R = -074 with 95% condence intra\n1092 to 0.29, P= 0.006, Figure 3) a correlation that\nwas also found between NpPROCHO 5-min mean:\npower performance and each ofthe subcomponents of\nhe performance factor (Winn Pearson R = \"0.74, P=\n005; VOrn,Peaeson R = \"0.57, P= 002 and 5-ain\nmean-power-output from the familiarization test,", "Fats 2 Hert rete FR), oxygen comsenptien [Wota) endl reqpielery sachenges reve (88) Maing 120 ran abeeminel\nying a 50% of maximal oerbie power with ingestion of either carbohydrate (CHO), protein + carbohydrate\nSaneues ex ekteasiaart ¢ pashan o codcenhene terensice", "eee 2 eens ree eens eae eee) ee. eee) fees Seegenr eee Eerie eevee: PrWvitees dee ane\nsn ater 120-min of sbmarimal ceing at 50% of maximal aerobic power with ingestion of ether carbohydrate\nSCREPA, Eemtelax «cote laedaehn GPRENEaIND or Riumneetaer™ « iemeteha 4 ciceahaniggs EaePEEIEIPA.", "", "ae", "Degree of completion HR Gopm) ______VO2 bnbgeteni ty _\nGio PROTO AGRO CHO PROCHO Np ROH _c10__ PROTIO_RPROCT", "Depo ct cemplction Letetetmeelt} _GiawseGeme) Ne\nGio POCO _NPROTO_CHO—_PROCHO_NBROT_C10_—_PROCRO__1pFROTS", "", "120 min subrnaxirnal exercise", ">-min mean-power test performance" ]

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[ "ze ee injection. In Wak Type mesenteric arteries, b> administration\ngan alenated the cata response othe c-aenaepo\neons hele (FE) (hg SA: POLS) Ts using theca\nrace espe wa prevented in the presence af NAME (i 5)\nhha here was ologer asa leer vases\npete saline treated Psst wildtype mie Ta ai\nhat increased NOS-detved NO i response forthe decrease\nseco espana seni ates rm Peat vi\nYe. Sma Bigs were ao observed when Iremboxane A\nit GGT wat aed Se 081 suggesting he hae\naocostctr response wa ot eto spec etn of cep\ngaling oa axa sath mast ces Incest\nins ia wiype mie LS eaten i Gh ere me ese\nao niet alain vatcosttr response a ether PE\nD468 (Fig 3A and B especie) Further, NAME eaten\nhan elle on contac respnse in LS wented Cah\ncites Seen,", "es aarennrar reir pi bonept enare-pentors.mumsprale repre mrs\npons o acetylcholine was sigcanty pated in hI Tez\nresents when copare with hat nw ype mesenter\nsess (P- 0001 alain Sweat ede dpendet\nsedation was significantly mpaedin wild-type mesenteric ate\n(05) but unred in anTadre eseatee\nht endathchum dependent acaaion was lege een be\nween LSet wd typeans eae Ghat sete\nreves (fig 3) Fuerte LPS emesis reduced the\note af eadotelum ndependent vasodilatation to SNP ia\nype mesenteric ates when compare to mesentei ais fo\nne trated wide mc (Fie 3. P= O05. contast PS eat\nnet hs se let nederdel\nion to mesh dee meson ate Thing nie\nht nde cel I eles Sind vase ditution", "ee ee eee\na futon in espns 10a ier dos ofS ap dear ndction\nsur NOS expression slated mouse St ings om wl\nnd ohare ie were ince in Dube Made Eg\nedn (DMEM) wher wahoo Stor 2 Flowing\nuhaon, CCH protein expression, Bt ad al opera evel\nveep incase both wpe and ah Tees\na0 Band) The ndction of ths pty assent set\nin Wye ras, eng the endothe component se\npase. Watern Bl aaj demostated that eNOS std 10\ntein expesions were as sini snreased nba wl\nype and Crh Tiedt ots allowing LS incon (Fi\nrd) pata the inaction ts NOS snd sNOS by LPS was\n12 shales magnitae in bach genanypes,", "Wie nes Senegal is aie at emnetenee call ne Aenea\nsear uncon in sti igs ete ih 5 i. nai\nvith LS sigan unease contrac fucin of wl\nype ari igs vespanse fo phesiephie (PE) computed\nine teed wid-¢ype cata the presence of UNAM soc\nron wasinresid sich ha vsootarcion was to tanger ier\nnf ete cond LS ete aorta In oh see sts\neaation wih LS had no sgn elt ot vsocnealyco\na a eat nected toh tito eaten he oa,", "a ee\nease vasculat GTPCH and BH levels in wipe ie, bl he\nogni of thi ntee is ated in Geheare ie\n\nenaaing pc nl lc of hs en\nsponse san patent ef enatele-dpendent a ep\n\nfect vsdiutaton in mesenteric arenes fom wd-ype mis\n\netch ae peeved in sentria om Gh Mihce wae\nonstrvesposes in wy abi, which aga does ot oc\ni Gh eee srs dspe bdctonf NDS and eNOS protein\n\nresin sb gets eth the lk endothe cel Bi\n\nlls ina ales of LPS-induced hypotension. Together hese\nndings emontae or the it net dienyl\n|G apd hs IM sates aloe suet a pete agi\nPndcd vec tacts tiypetenon add by te se\n195 wed here idcating a ove leo date ell Ch an\nsu dependent NOS elton inte pthagenes lS nde as\nein leaner", "Se ee ee\nil B-dependent NOS ceultion inthe plhogeness of LP\nsndurod unstedar dyafimction ead byypensaeics: The safer Radiat of", "ele rlo dlalersinaeeianr serine nian tai ngpiaaarmte\npci PS causes an crease ia vasclt Geh mRNA, CTP presen\nexpres and eves cori mie wih NOS mR\nih ht Vasc NOS-erved NO inrented (2.2125, Conse\nly GTR pret a Bel ene el eh ses Sc\nsas lana eas Fos wale me We tae peu\nved thatthe my of vasa GTPCH and Ba ashes\n70) are contbated bythe etl shel mice [7 an\naan 1] Th the eden nye pel ste of sy\nbis alowing LS tester ned endtela dena ds\ndation asc Bv eel aorta om DS ated wd\nbat natered in LPS tetedCchiTeaee ie, densa\nvolvement of eat els CTPH apd BH teats\nPrinduced endnote Hower, a siitesnt ition oe\nsleeved in Cee srt ese el pe\napelin at panier an", "a gia rs cletahr ab tet hacia = ce\nsean sorte NOS protein noth type and Gen Tere ie\nwas served nesting) ar NOS expesioa was ao marked\ncreated in bth genayper flowing PS ex i, Tis aces\nNOS expression ay ae aba polecve bcs in endtonera\netinaingt the eanenaes of micron ew However\nhe ti balan stem acs inthe absenee fled ow a\nhe suing shee stress an the vessel wal ae ast be ken\n\nraping hese ress ote ive Stull However cease\nNOS expessn hasbeen dounened neste ais al hl\n\nal mule ora vo expestetal Model of LS indeed\ndora) cota eNOS expression eened i vac\n\nrte om npr deo sre cept shock 2d\n\nating tar vac eNOS expression dependent on he seve\nses ney LS nthe preset sty we und th ee\nascot sponse eee by LAME in eset ater\nom wi ypemicelallowing Lin tsi hat iss eat\n\nby LPS induced inreass oni NOS detivedNO. acon\nwd ype mesenteric\n\ntor responses nese arteries tom Gehl\" dere mice\n\nila findings were as observed in condi arteries (ots) fo\nchP enon aie pee lncubaned wth IPS x vie.", "ey Ca eee ee ee eee a tolone\njon were enplzed in esenaiatetes om wile mie low:\ngsi Tis ids vas coset wth revous pet Wh\nrials desiedderene sensi to NO wing LS eat\nea and hs as sown to be NOS dependent he mseney 5\n9} teats LPS a sian elec on ele endatelas\nJpendeno independent vasodilation a Cb \"ede me\nsoning LPS hr viv. indicating thar che inabliy on induce ondathatta", "Coa", "" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2 ]

[ "pus elicactously reiecting the ebects of environmental\nchanges (Figures 4 and SB) On the contrary, the average\nsbundances of sampled maccoinverteates fled to detec\nhis change in two out of three basins (m2 and 3) char\nacterized by more steady 1sets of phyleal-chemia\nverameters (Figure 5A).", "_Nempora’ changes in the degree of specialization were\nsociated with the environmental ictustons, which\nver turn elated to the ferent sates of the hab.\nThe highest values of SI have been recorded during the\npal period, when the lack of human intervention mod\nid the euelemementad enututers cites aueins uecio", "Table 2 List of the benthic macroinvertebrates found in the Tarquinia Saltworks during the fourteen years of the study", "saree ee Gomes apd tech Bras Pen) EASTON EEOC Teneo \"", "ee... 2...\nPhyl carer sn beat Ta Eanophene\nTas aepa—TRaeare SSS aT Bae\n2 Cerapancpnss Gnbudgaum gute 182) Mere x .\n2: Nespas toi cmiOh4 981 Say .\n‘ rumors Oatimante Dm) Smash x\ns Cepancse darmans Cian engienin Mae .\n‘cen 18\n5 otis ews Atma ach 8) decsh .\nCeniagece Bagi tr gs .\n8 Wytods —ayeaserp Moneta 8H) Mare .\n1 Amels Potent Gai) Ranma igas Gabe HSS) Mere x .\nn Spends Gockacier Gate WD Mme .\n2 Catalin Gptecptan a, VR) Commaplon x .\nFen\n2 Presoads Neh mas lng, 186) Mme\n“ meetin Gute, 8k) Mare x .\n5 ptosis Mr .\n, Sotalas Aryans 1S) Mere\nnske Pots Capa 188) Mae .\nmi\n\" ety olga rae Comapion x .\n9 Anopass Vabcnacs hopes tab Palak 72) Salk .\n0 \\grovarosmne Fea 72) Mere\n. its reson Me x .\n2 Germccanpeast nares 188) Mere x .\neats team ins) ig TS Common x .\n6 (omen) nse) Cexmoplan .\ntenes rola Menatiea Cenphnmencn? sea 8) reach .\n8 Pnfernes Rhaaps als Spach ap Eerbg1) Mane .\nCnn Anberlin Fn me, Mahe ." ]

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[ "eres The Comler ancl mcdecuiey reacrenisns of iiigamnetcry Ecawe Ciapees Bee nee Gy UNCER\nreweve, data inte that uncontold chan infammon induced by bacteal gene product including\nipotechoie ald LTA), may tnger colonic inflammation resuting in cesave pathageness LTA 9 constuent\naycolid of Gran-postve bacena that shares many ilammatory properties with ipopalysccharide and pays a\ntal ol nthe pathogenesis of severe ilarmatory responses va Toke ceptor 2. Accordingly, we elicit\nfi role of LTA In bamene stiadetion end Inckuced cola bs vivo.", "Methedn To better understand tie moleculer mechesioms Usllzed by the intestinal microbiots end their gene\nproducts to induce or subvert lamation, specially the eflecs) of atered suace layer protein exesson on\nhe LTasmediated proinflammatory response the Lactobacs acdophiussutace layer eoten (Sb) genes\nencoding ip and SIpK were delete resuting i 2 Sips and SIpK mutant that continued to expres SIpa\nsccaney 6s NOREEN.", "mE NN, Slates eM EEUTS aeat e Te S e eene Reee e eee Pee ae\npurified Stgphyacaccus aueusLTA In contrary tothe LTAdeficentsvain NCQOZS, the LTA-expresing strans\nNCQOS are NCKSE, aswell 35S aureus4TA induce prosnfammatory innate and Tell mmiane responses In\nvio, Additonal nether NCI2O3! nor 5. queus4TA supplemented in dnkng water protected mie fom\n\nDes colin, Luk iratend, induced slgrlicarst hnestiel Ilemention resting kreeene colts and Govue destruction", "Comckeioens These findings suggest thet claected eeration of tan of te f ackkpeaar MCFA-Sps ol nok\nsrulicede LTAMrchzad pre iilocmatcry igus end asteoreart colle.", "Keywords: Dendritic cell, Dextran sulfate sodium, Inflammatory bowel disease, Lipoteschoic acid, Toll-like receptor 2", "cratrce REbanGn Wa. bare, Het Foe bere Gelcee nee\n2.31. Although the etiology of IBD ts stl unknown,\nsaggerated inflammation induced by activate innate\nrmmune celle via thelr interaction wth the microbiota\nind their gene products, as well as inflating CDA”\nIFNy’ T cell, likely play key roles in uncontrolled\niflamation and teue destruction 1-6) Foxpl reg\ntory T cells (Teegs) also critially contol intestinal\nnilammation [7] and sigalicaally prevent clits [8].\nigen 8 pivotal role for Tregs in intestinal immune\neink", "tas Ipceaeeiaadba ent act hnae deere ior\ndent commensal mlcroorganers while raining the\nbility to defend against potential microbial challenge.\nThis lmeoune tolerance isa highly regulated proces\ncomprised af a myriad of bological checkpoints neces\nary to malstain homeostasis between the host and the\njut microbiota [1 In instances of inlammatory bowel\nlisease (IBD, this tolerance between immune cll and\nntestinal bacteria is disrupted; however, causes of this", "A eniamentel challenge in payweating am knbelenced\nromune rexponse isthe understanding of ow the hos\nmune system distinguishes a pathogen from norma\niceestinad naan, (les ob toe cxmeenamedl eclorcermeadans", "Mojgan Zacieh’, Mohammad W Khan’, Yong Jun Goh’, Kurt Sella’, Jennifer L Owen’, Todd Kiaenhammer’ and\nMansour Mohamadzadeh\"™", "Induction of intestinal pro-inflammatory immune\nresponses by lipoteichoic acid", "Abstract", "Background" ]

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[ "mchediy Seereneenh ie ONerm, Mievia) Tene Oe ire\nin v0 (P=O0i8, Fig. te). ln conclusion, these in wo\nperiments suggested that GPA i ental for promot\nny the peritoneal metastasis of GC celle.", "arnngeams conticmed thet BOC-SAH/NC andl MERINGMA.\nvis developed larger tumors with more organ iavave\nment in the abdominal cavity (peitoneum, mesentery,\nLaphragm, and ler) (ite and Figure 55. Moreove,\nice inoculated with GC-#23/¢h call exhibited longe\nwerall survival chan mice injected with BGC-823/NC\nsella (P — 0.025, Fig. 4d). In contrast, upregulation of GOA", "Sereeel SP 1-einding shee wore Kieatiied on the pee\nmoter of GPA, and the knockdowa of SPI in BGC-823\nlls markedly decreased GOA expresion (Fig $3). On the\npase of these findings and thove of cur previous sty\nowing that Reg IV activates SPI, we transfected Reg\nV into MKNC28 cele These cols exhbied signal\nneeased GIA and p-SPL protein levels (Fig 5) Fur\nhermare, the depletion of SPL expression abrogated the\nduction of G9A by Reg IV (Pi. 5), and G9A suppres\non also attenuate the eflets of RegV on adhesion snd\nvasion (P< 005, Fg. Sy). Moreover, a. chromatin\nmmunopreciptaion (CAD). assy in BGC823. ells\nJemonateated that $P1 drelly bound to the G9A pro\nater and promoted GOA transcription (Fig. 5d), This\nnding wae contrmed by the ca-transtction of Reg IV\nandthe GIA promoter which increased lcferase actly\nin GC ells, whereas the depletion of SPL expression\nenuated the dneeate in lucierase activity in MKN-28\nlls (P<, Fg 5). ERK, an upstream molecular o\nSL, is abo activated by Reg IV. Therefore, we inves\nated its role in GBA induction by examining pSPL. As\nhows in Fig. Sf, peeveatment with the ERK isha\nPDORISD attenuated increases in the GPA and p-SPI\npoten levels. These results demonstrated that the p\nERK/p-SP! pathway i ati for the link betwen Reg IV\naa", "EDGES: & member of the integrin tamiy. pays\nportant role in the peritoneal metastasis of GC\nTherefore we examined the ably of GOA to regulate\nSTGRS expreacion in GC celle. Specifically, silencing GOA", "pordelireesener pismo pinerhn canal", "Table? Multivariate Cox regression analysis of the\ncel sual at 10) oc eect.", "", "——————\nFosine Wine\nne ina3s)\neen se", "", "Reg IV promotes G9A expression via phospho-extracellular\nsal-remsisted|kdimes Lb tainty SP seeaotion", "————E————EE—E\ninduced THGDn enpieeetan" ]

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[ "ee eee ee Se cee ree ee ee\nance il ey proms Rgh durability he parte resanes\ncare Nevers the deployment of vases with PIB o Fath\ntoca wena doar sb ied empresa\navid gale oper aapation to genes cated wih\na", "DE aS i Sees 1 eee eee Ce\nsnang plats and ave bon well decanted fr higher plat\nrie aad, es Na hs Dns\nemer older leaves aking yung eve ore ative\nstore (oly, ou Ae, 1950), Perera gates\nrots betes and dues (eye 2, Young pet\neigen tendo been eet (isl, 88); eee\nretiring ce aul be expected fo make hie owes\nbere estan parla in ais wih ao resin\nees Hower, several Sas sgt tha his ental tthe\nie, bt that oer ce plants on ecm cen ra\nsore, pores plntappes and leatopper (bins\nsaa cay 20,2), Te ese om the pest sy a\nan te in Rng rsa opathoppes ole\ntat ng sn venti Fre\nx plant age even on copie varieties eran e205) Wi\nty tat sch pal bret nee the resane of 12 o", "Pend snpaerbacengy- ditched heer daria omer eames\nian speals such a monopapocs planers a ele\nin oe yn ad nt eatin wih\nrhage pala ying\nants can often cmpemate wel or berber damage by rou\ntet anion els or by praing new es (se sod Oh", "am renter plant stearce (Rubin ct ol., 2900), This mppeeny to reinte 2\nerasing ty fr rer plat parton revue sy as\nmg an tv fe he ng tod ae\nNishi and Hench 1007 bre a, 109; abi Sache es\n\noo", "We expected that older IR20 and IN62 plants (at low nitrogen levels)\nvould tert plathoppers by coniutg t route mae 0 Fe\nroduc ngs uh alsa ra erga 2)\na rene experimen, IZ plans need le sage he\nser li) cnet ae rece hn Pa\nbal peo the lanier a pele bat oer\nas mere aot appeeialy more ser than jouer plan,\noaghthe ot ad bot a RG planed a ea ering\nDAS tendo onercompente fa plntopper amaze The gree\nees tlre in ering IE (ompared to rela 2)\nernest whee rented nee innate Pr\nanhapper on ling RGD plane dept decrening plop\nann en Decresing lean made IG pan te\npli, bt might be duct eclogite fs beeen reste\nlier msstnaes oom us snd Larchra 20 es\nln et 20), Peo sadist ater ce beivees ve\nnicted ler tolerance and preter efi o iel pareaah\nee cites vies sheds as cual ig cnet deans umes", "in our experiments, planthopper fines ofira ineressed om. high\nsoon pam, pars rng ate ering stage (5, DAS\nrh ange ferent esitance snes campromard by hgh\n\noes criens Slim snd Sonn 994, Vac a 204 Hora\na aes ssn al 2010, he pest tay, plntoppet\ncer high nigen However, mph blamasdensy dein i\npared change in pahopper bana (parila anf\nmales nd eg yng daring poplin evelopment. Tir war ee\nened under higher nope eines during the 2011 eld exper\n\nenn to hgh ling a2 pam toplabonpe dag\n012 (thee centr were sported by vee fom te srenhoa\nperiment). Ths apart apc of R62 to ter late ro\nanapper damage than IE andthe posit hat folerance\nsth ame ines os kr ph tan hon\nown plathopper damage sang ls grown re pln and\neningy severe damage dew bown fathers nde igh a\n\nroe (Cy ea, 197; hang ad Cheng 2008 Cr 201\nea als) Wetabeve that hi iference ay bette\npean nN ance preva ese oy xine eas\ncept artes (ua Sache t 199, Snasan ea\n\nwhongeamenpryp try", "cota results indicate: that farmers msing high fertilizer applications on\n52 wil not apprecalyscteerate adaptation by plnthoppers othe\nae) specie resistance poe, However, ents R62 tera\nfey lnboppr th Sei (noted nc Bl experiment\nere potest for lstopper dap tthe are ae Fer\n1S, 2s foe ater af popper adoption RS). Cae\nnmr cal 904 Set 190) and by avg eugene\npete (Gallahe o y 904 ih, 190 19040) eal\nsce pan thrugh actos of interacting gens (Fs cra\n\nsa Hoga (2018) have need tse all\naes hgh to pes he Bt lca othe lend reed\ncurate lingerie aunt he ron lathe ve i\nilpnes~ highlighting the rl of cece ce gees Sd ah\nrin enhancing restoce ea Fale ase, 2012)\nfathermere nit ca”) hve deat tat platoon\nri the Hpi Tony atlang the developing ee panies bu\nrat he ph Tease By atincking the Gevelopiag ie panicles bus", "4.3. Ontegenetic changes in resistance and tolerance", "4.4. Stability of resistance and tolerance under high nitrogen", "4.5. implicanons for crop management" ]

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[ 13407.663241889415, 65550.21255326737, 27867.56672228407, 13228.87058329722, 52250.54650753038, 82225.27121826727, 57502.304663484916, 1743.0302480979808, 2018.5536351806513, 1294.8375123381848 ]

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[ "Purpose: G Protein-Coupled Receptors (GPCRs) are a large family of therapeutically important proteins and as diverse\nX-ray structures become available it is increasingly possible to leverage structural information for rational drug design,", "We FREE Nagel SPEER CTS Tt Ue GEC REET MIERACIES CORN) WEN QTE, BUEVEYS Co the Kincing we\n(AID, proving an enhanced uggabity an ligand desgn approach, vith actual understanding of hgand\nbinding, including a ‘magic’ methyl and binding site mutations, and a fast new approach to genevate and score waters", "Methods: The GRID program was used to identify lpaphaic and hyciragen bonding hotspots Expicit Rall water\nretwors were generated and scoed for (pseudclapo stucres and igandpreten complexes sing anew preach\nWatrFLAP (Molecular Discover), together wth Wate (Schrodinger fr (aseudolapo structures. A Scoving\nfunction (Metacore) was developed using 2 fast computational protocol based an several short adiabatic\nbiased MD simulations followed by multiple short well-tempered metadynarnics runs.", "Results: Analysis of diverse ligands binding ta the adenosine Aa, receptor tagether with new structumes for the\nSik/y opioid and CCRS receptors confimed the key role of lipophilic hatspts in driving ligand binding and\nhas design the displacement of unhappy waters generally found in these regions provides a key binding\nenergy component. Compete explicit water networks could be robustly generated for protein ligand complexes\nsing @ WatetFLAP based approsch. They provide a structural understanding of stucureactivty relationships\ntuch 35a magic methy effect and with the metadynamics approach a useful estimation of the binding eneray\n“hanges resulting from active site mutations.", "Conclusions; The promise Of full stucture-besed Orug Gesign GEDC) for GPCRs [5 now posse using & combination:\nof advanced expetmenal and computational data, The conformational themasablton of ta protein rouge\nhe ably to easly gaverate biophysical screening data nding including Fagments, kinetics) and to get etal,\nsructures with bath potent and weak igards. Expt water networks for apo and igand: complex structures ae\niia thd cimension’ for SEDO and ae key for understanding gad binding energies and knetics. GIO\nipophllc hotspots are found tobe key cvers fr binding In this context high ena GPCR ligand design is now\nrabled.", "Keywords: GPCR; StaR, GRID; WaterMap, WaterFLAP, metadynamics; A».", "Jonathan S Mason\", Andrea Bortolato\"\", Dahlia R Weiss\", Francesca Deflorian', Benjamin Tehan'\nsnd Fiona H Marshall?", "High end GPCR design: crafted ligand design and\ndruggability analysis using protein structure,\nlipophilic hotspots and explicit water networks", "Abstract" ]

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[ 1, 1, 1, 1, 1, 1, 1, 2, 2 ]

[ "eee a eae eso wheezng Gunny early chwanooe\nnay ndeate eences ae. a pags af\nexpat ese. Ingrvd haratisson of\nseing phen cau ad tothe eatin ot\nitera eres on he delogment of asthma\nval cians ences ld eatheceeed Kenai", "arrays hem pate tare ee\nies rom bt a7 yes am 8265 chien n 3.\nanti Beth Eat he ALSPAC stu) were\nrsd. Late dass tas was sed 1 assign\nnays based on pata of whee. Measures\nap, aay acon fled expat vires\nFE) mi faced erty tow FE ad\nwonchial responsiveness wore mada at 78 years of age", "ersten irae Linehan mieten al\nsoci haley away espsiness we\nand for eemedate oe! (18 nat) whozng (OR\ner py 836, 95% 05.2 013A man erect\n\nos espns a matali 17,041.41 8 2.1\nFV, pro congue wih euenove whee\nhana Lat ent whoeang ate 2 mans) was\nis associated wih apy (ORB, 95% C7 to 94).\nrd arwayresprseess (ex fierce 181, 95% 0\n137 t 185 SFE, per yn, arse and preoged\nsty eee wr et asad wath gy Bt were\nvey aso wth reed sy espe\nrd prsston heared meme assosatns wi\nHeageerdanle", "Se ee yee\nsocaled with py asa esses we\norcteod by et tr age 8 mat. Th hs\nel implant tig of rere\nmeres on te ton of ape wee ety\nan", "nstima is @ Complex heterogeneous disease come\nrising a numberof discrete phenotypes such that\nhe tem “asthia\" hae recently been called into\njusion’ Cao! studies fllowed to adulthood\nfave spate hat more even chldhod wheezing\nshenotypes se ler ely to remit in later ie\nlmonsry fuetion abnormalities asecated with\nprasent wheazing bocome estab daring\nly choad and wack toad ie, suggesting\nha eal ie exporues sects is deeming\nhe onart and natural history of wheezing i\nnesses” Ap improved undentnding of thes\nshentypes i therfore of fundamentl spor\nance to suis of nid factors for atonal\nvisising Masia ie ade,", "J & semi’ report sased on be vueson\nChildsen's Respirtory Study, Marines and col:\nleaguer proposed. three putea of heen\ndang the fat 6 ens of lie leading to the\nconecpts of tans eit wheeaing ot the st\nS yeas, soatopc whertng in he, preschool\njena tnd Igbrasdated wheeze ov ‘thr\nAithough these have served ar sch modelo\nwheeting phenotypes carly cilhood these\nwen hae pheno.\nSyed and a ent pat deed weitions\na iamune vapors within seemiogly Rome\npeneous phenotypes of Ige-mediated arta’ We\ncud 2 novel symptomdevenapproseh to sein\nweting phenctfoct tng ope eneturcment\nowhecte ding theft? yer of chldhood in\niige populaion-hued bith cohort study, the\nfo Longitudinal Sud of Parent and Chien\n(ALSPAC) We svetigated ssoctons of thes\nphenotypes with physcin-dagnosed ath and\nSbjectly measured stop and ay Factions\nope 7-9 years,", "Aa Bs a long tudina’ population sased bats\ncohort study that retuned 14 541 pregant\nwomen resident in Avon, UK with expected date\nof devery 1 Apel 1991 t0 31 Decmber 192\nThere were 14003 liven chien, The study\npetal bat hen decid, previously\" \"and\nfarther details are shown onthe ALSPAC: webs\n(hetp://wwrwralepac bris-acuk).", "By ee\nstudy mothers were set a selfeompletion ques\ntone aout the eslth of thei ch They wer\nfled to teprt the occurence of 18 ornmon\nspams, slang wheesing, 2 the previous\nUF months (6 monte forthe ial queens)\nsdf erent, whether they consulted a doctor I\nseparate section they were shed whether inthe\npst 12 months (6 months in the fast question\nnie) their ch bd \"heen with hing on\nthe chest when (he breathed Ar OT months o\nage mothers wreaked in a separstequetonnaiz\ntcp if 3 pyc had ter to therm tha\na ad kod pane.", "ae NeOple status OF ne chu ren was determines\na 7-8 years fag by skin prick test esponses to\nual oF up ust comune amare ctadinn", "", "", "et He, ay of\nsata a ea\nate\nSet\neee\nee a\ntomtom\naie\nee\ncrite\neS\net ange", "Associations of wheezing phenotypes in the first\n6 years of life with atopy, lung function and airway\nresponsiveness in mid-childhood", "ABSTRACT", "METHODS", "Particapants", "Data collection" ]

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[ "arpeining Taek Phe stay sacwwed Chek: tae hewbenits level of\nlation reflects tat ofthe wan, as does the associated\nisk of anemia, The use of unbyglni ats i an impor:\nnt factor in Bangladesh because of the increased rk of\nvaraaitkc infestation ln the tropical climate. The asgoclation", "of woleppanic toilets with ansunia 39 explained by poor gra\nal health andor conic Mood las through gastos:\nial parasite infestaon. The majsty ofthe population o\nBangladeshi Musi. Now Muslin, mostly Hindus and\nSenindshc ieee a hile Migker raareiouee of icemeia ae", "Ean EBVCES OF CARTICGIRASEC BIC SOCIORCONOTTEC MACKIE Ch SENTRA LIFINE) [MURENNEOGRARC FERRERON, NENT PARGTION, amr arieeria\nwomen agad 15-40, Ranciatech 2011", "", "— aS a as eee\nPray tN ca ome on om sn aes\nPray tN) one cows ss oss tan ae\nnye ie ge\nes a et\nene at\n\ncaer concn we eons aos peas ows coe ae\nesa et\n\ncaer bestons mse anes pea tas ie\nesa et\n\nse srrone ane ams pea tats ae ae\nes a et\nde Pr aos aust cs mes tm wa\n\nIe Coup eae com peat aes ima\n\npo) ye Fk 1-200\n\nMeese\nroi tT ase ame peat owt eos ae" ]

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[ 13839.781196081312, 13781.96031372156, 6136.950295089497, 1639.436180978635, 255685.57711808675 ]

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[ "volumetric flask (5 ml) and made to volume with water.", "mani phat l,PO,) (859) were wei in", "meri seven water under ee eat and made ol", "Pl th the xepin of an eat hee ony = tne a", "foe a abl Zou eal 207), A weight of pondered de\n10 mg) was aed ta enrfge tbe (15 ml Coming) The rae\nume ofeach sc soon etn above) nd water are\nenpratre and hen pl adjutd agai a ble. Tuhes ae the\nsored in an oral shale and inca for 24h af 37°C a\nsl dg the ented (1,000 puna he pea\n0 wa sampled io determine the sland da conta\nERIC, leapeaadltins ca eetemrel ta ato!", "men are presented ni 1a broad range of sobly vasa\nered wh tg ty oe en\nrial fi (SF) andor human neti A HE\na 2010 and ar pled 1. Those ess aeons\naur Amarie-rmahnanacerape-pan.srdaryranenamiandah’ ng", "SO 00 al tie oe ee a ee\nal 2017) Dal meaarement ae ted for Cch dr lng Wi\nhe fal ange dats and played by sop. Fe si ge 2\nfe ste wth he lui of phenytoin very coset wl\nlmathcin shits nrge vray. respective pa of the\ndigs and 45 cul ex th erence sce peste\nend oer the experimental pl range whi inane Pe\nfinn nee Innis ndonetoine me opie og\np= 4:3} whic linen te ierction with he cle pare Fo\nase rags 1b) aaa eave te pei ed a\ned apepint nt show te sane cess. The fal ange De\nhs fd wale (ocr of magia) nao the bation\nher darts Ths compa har the hgh log Pele (34\nep which ned rs ios\nad eel iannlins as alse tania sts aeasn cue", "sao secmeesen peeiemes salaeecassces Bia ene noon he\nee: gies tyre a ach Dk i epi\ncei ha ln np me eye\ngn ya ei\nrico ar i", "", "AIOE 4S.ain AMD tl ime inn AN accel LOG iat", "", "i WEt gees 8\ntity\nAd gee", "23.2 Preparation of aqueous stock solutions", "23.2 Preparation of measurements solutions", "2.3.4. Determination of equilibrium sottbiliry", "", "2.1. Eguilibrian solubiliry measurements", "" ]

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[ "factors, for example, specimen quality, in more detail. The ethic-\naly approved databace doce not contain general practze dt\np we cannot sue poeumona incidence in peer practice\n“tough other sues hve done tha!” We san anno deny\nwhether gral changes ware made i refer patie ding\nhe sud perio, although there was no evadence of map\nripct ofthe reorganisation of uta hours erie i 2008\nEven within our homptal data, tw ky test roti aed\nspose and se peumona Were not sale, arc che\nKrys and loo gate meter were other ei dat sch 3\nood presure and eaprzry rate Wie thee would have\nsen sional infrmation, he lick of cially elvan\nanges in other important seventy biomarkers soggss they\nwosld he ually to produce stanly eiferent rl\nOther penal confounding Iaor tha cama be acoanted\njoe any dying secondary dats clade howe casey\nfenge in cgaetoal clare o ot recoded nthe pt\nstem homere, we could not Menly any major changer\nRsthar provision that coveted wth the are in Poe\nmonia rend rom 2008. Our dy 3 ingle opal pou,\nsn 2 recent stdy investigating CAP in people oer 68 years\nmin the UK community fund an anenpectedly high weal\nze nthe South Central region which oat hort eve) fo\nrasont which ae uacem aa further stdir ae nerd to\nplore the generality of thee Bindings. However, hi\npe cali wh the rowel elle data mali, =\nsa knowledge ter only one other UK hosp group with\ncomparable database kinking admissions to Lbtratoss texe.", "Toe Lies tapeee Dee Rene etree Re be a hey Caen Oat\nJsgensawithing, ean tthe appearance of Eling paca\nmae betwee 2003 and 2009,\" which may not be mie\nHowever ts not he catne of the peamonin reese eon\nhere tl ely acorn a ur om (200\npomary dagose neler species in 2014), and sho i\npsy an serening Wend. A moore recent US adh which\nmumted separ diaproes together with pcan found an\neal irene bec 1993 ad 2011 we sp Denk ther\nvor large national ces nthe pacumnonia explo te\nstwcen 1997 and 2011 Hoeven le nt ans al hes\nrae ed dagen codes nolan. We were not ae oe\nfot lage popalinrbned sade, sea sure\nsama kaseriar ct paasmule meena of ebaieen,", "of comet, whet Capel we cio wheat 2? Wie Rave lnrentignied\nvera poten cae, bat fuer ponies ncade chang\nlevels of deprivation, a8 cree sn comorbidities not cap\ncred witha our dat (ven the confounding ofthe Chas\nomorhiey sore by coding depth five one spleen\nigre SI and 2) and redaced aces to wut of hors prin\nie lntng people to come dey to het. Nevertrle\n= ely tat mull factors are contig to the nce,\nsther than thee ing 2 single cate. Hitorcall, peu\nav been comidered predoransotly hace in atl ith\nptemorise the leading orgasim\" Howene, we fond\nnone organi relly rately in only 59H of ees 201\nio where a clare ap pecfommed, potentially Beso o\nopto on curly antbiote iitaon in emergency a\nons though so ly dae to ieretcificales in lating\nzoning ing colurchased metods Vaction pro\nganmer have nignieany redaced the scence of vai\npocumococtal dace st southern Eagan” ough\nrye), but S.fctmomae wan il the mom comer\naonve organi found. However, dominance i decree\nng, ahd ober oranuins,partully Enteracenacse sac\n2B col and Kleblla spare becoming more prevalent. Thi\n= pariclny concerning pen thr high rates Of eine\nspiel antoncr commonly recommended for CAB\nAenough these pathogens fine traiomally been viewed\nsot with hon acied pean we found se\nCAP eres in pants woe any recent previo hori\nSpore, ond aecimens we then voy clan fo uinionoe\nogesing ths highly wntly eo be deven by mca\npopalacgured paeumons Tere were no changes in hor\npocedre mprng specimen callow procentng tat col\npve came tho: any eve sch changes would be aoa\nvith an immediate snidene change eather thas the prada\nvvar-on-year increme we observed.", "ae, Raia, eta eee queen te, eee ee\nsasas Set the cheateed Lecmanas to CAR aad cacoma named", "Dep eeey eet eee ien Wn ine oe cee\nor spel otnote pring the UK, scouting for ov\nS096 of prscpions Thus CAP cress wll dave ince\n annbine preebing and, unalone, hinder our ex\nfhemps fo seer ana mes key pare nce\nrtimahal tnce, Animal suds mage that stb\nJnven mcrbora depletion can ipa saeco\nrlonas™ and acer challenges\" ring he ncing pom\nrity he ineesing we of ani ese prnied ace\nrfp could suaiy be havng the unter comsexuee\ni iocrening their inckenceFarher rene micreie\nodes could ivesigae ths Iypothess m_umanc. Wear\nrate to anew Whether namacoblgially confined CAP\nes actly wth the dats avai and wale HIN pa\nlec infenza may hae ben partly espensbl for ince\n2009 2010, ths would or explain the eeersncenng wend\nDelp rap pinta gna t dently ial vem\npater atopy wil be cui to supprt the clan in a\ncing the ney senrtion of ani (empaied b\nsonal” snd sternasonal” pucines, agains reac\nvoneewaryannotc procnpions A beter andertanaing\norccause or talred sadhode dart may sl sti\nducing antibiotic exposure.", "‘fn summary, this study suggests that rather than discounting\nporcncs fr pemmnin wivaaiocs w singly inicave of\nrows, ageing population, or an area of documentation o\nrlthaeseching Eckavow, we shold be actively scacing\nforthe reason behind the incemey a0 well a planning ou\nlth sens apropritly—for the increase admin\n“and ta mitigare’ the porential ‘colloreral damage’ ol", "Figure 3 Micrabiologicaly canfiemed community-acquired preumania\nhe ert Sire trar yeni peor arg", "‘atoll:\n“HGEGEERELEEEEEE" ]

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[ 1, 1, 1, 1, 1, 1, 1, 5 ]

[ "qe ee a a routes 8\ncal dened mul eles COM) fave nat\nwrvicuty boon irwastigatod.", "guia hile anorertinsrreie- Paneer\nsus corpased, patna, of Heathy sje,\nresthy ats ler tan CONS tet. stents\nfat by cher alc drases ad co cat\nalta yer anos bt sched fer\nenyaphy WAC) bind anderwet carb\nentra an etsane ele Dp ih esa\ni exainaten (CESECD) aed at detcig tes\nwo of fe prance of anorabus vero ata.\ncringe TEESE seen patente an HA\nter revert scl ergy of the nus\nruven jst with enous presse", "ee ee ae\nsete darataly associate (3, 95% C120 0 5,\n<A) Subsementy, veagaphy dononsited\nPOMS, ad at nal, the presence ruie\nes entavai sens, frig the chee\neros venus Segre, is pos acto\nani cetebospalvnes isuficerey (COS wrth\nju rent patos of dba of snus ae\nistic Moot ren ng an\neons pogesive cuss wee asecated wth\nSM patos signin eet om hose\nrina pogese p=0.00). Fahy, he pressure\nant moasyed acess the vas isos was\nsofty but signdicardy higher.", "maeag-ipeiiied dade We emncd i haadals\nnao ths ot pris been seed\ntafcteod by abel vrs haemosarics\neerie by bacanl mule vos cus of\nknown rig. Theat eau bean ys\niy rob detain the local couse af te\nFog", "Seat te te AE ce dy come\ninating. daease of the central nervous system\n(CNS) of unknown pathogenei” MR venoges\nthy and portions ude have demons\n capegric comrpondenee beeen MS plaque\neral venous system. The drainage through\nhe etrcrnial vena crtflow eutes as no\nsreviously been tweatigated in MS patients,", "grocene favours venous return fo ee night neat,\nich can be easly assed with high elton\nmtoclour Doplr (ECD) an ener calour\nded Dope sonography (TCC), which represent\nsn ideal metho ty whch to investigate the hao\nByes of cobra eras exam\" In aon\nECD cain the postural conta of the ecarai\nseclow pushonie’ be bike", "says fundamental role sm ensuring the core\nirvepinal wacus rtf A the eof ei\non the ntathorace psu is approxi\n“Sem HO, and iapsstion causes 8 epatoy\nmisc ation tat cn generate an een\ntatharaci pocsoure, fon HO. The resulting", "SB contrast, Ny and Selective injection venogra:\nphy se of course listed in evaluating cerebral\nvenous buemodynamice under ellen postr\nfad stpatony conditions, Howevey, the ter\ncecaly prove ceclent. morphol ba\na dee", "UNE Present phe restits OF & stucly Bhat evaluates\nthe abnormalities ofthe cerebral venous outflow i\nptients wath MS using ECD-TCCS and selective\nen", "ee ee ee oy conway\nfined MS (CDMS) and diagnosed accarding\nthe reviaed McDonallesteaa” Thr group\ncluded 35 patente with a relapsing emirin\n(RR lineal ours 20 ith secondary proses\nSP), and. 10 with primary propessve (P\ncutee\" A relative expanded diy dee\ncore (EDSS) wa attributed t0 each group\nDet data sguing ther lina, demopeaphi,\nted. genetic chancteistcn, MAI examination\npeace of cipeconal bands in the cvbrepind\nusd (CSF) are provided in table. PP patient an\n1d cut of $8 RRSP were nt under treatment a\nhac of as enon,", "eee ee\ndivided as follow:", "", "“~", "iy Dagarrnent of Heard,", "” ant pathway in the supine position, com\nEred by a increased era score\nthe itera jugar vein (CSA) rated\nincreised Hood ahi in that postr; and\n\n» retrcion of weno Ha to the vectra\n‘eins (VV) occurs in the upg postion\neins (VV) occurs in the upright pastion", "appr wth MS pets MC).\n\n, Bie dnay\nSohvesetig ty\nSerine\nSinlgep relate\nthe das", "Chronic cerebrospinal venous insufficiency in\npatients with multiple sclerosis", "ABSTRALT", "METHODS", "Non-invasive screening", "Pabents and controts" ]

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[ "oximetry, and tests of functlona® capabwities. fcic-\nconsultations have been found to be feasible,” reli\nable,\" and dramatically reduce the amount of\nrave by patients” Teleconsultations ae a promising\nmeans fo connect rural patients with respiratory spe\ncilists and provide an exciting opportunity #0\nimprove access to consultation services.", "SS ee\ndeliver information and services that pertain tothe\nmanagement of patients\" condition. Such platforms\ncan be designed far HCPs to enhance knowledge of\ndisease management program components as well a\nfacilitate the delivery of an intervention to patients\nTele-education platforms can also be designed for\npatients to facilitate dissase self-management knowl\nedge and support the uptake of self-management\ninterventions. There is a growing interest among\nCOPD patients to use web-based and alternative tech\nnologies to receive disease-management information\nA survey conducted by Rogers etal. in 75 COPD\npatients indicated that 77% of respondents wanted to\nreceived health and disase-management information\nusing either web or phone-based applications, with\n$1% preferring to access information with a computer.\nGiven the interest among patients o access information\nabout disease management, tis important that quali\nfied clinicians and researchers develop accurate, use\nful, and user-tiendly resources fr patients to access\nCurrently, there are numerous online education\nplatforms Tor patients with COPD, including those\ndeveloped by professional associations, as well as\nhose developed public-private partnerships, such as\nLiving Well with COPD (LWWCOPD; available a\nLivingWellWithCOPD.com).", "Oo he paysician af fhe ost institubon Vid vidcocon-\nferencing software, The telehealth sites joined the\neducation sessions atthe host institution remotely\nvia videoconferencing software and patients\nrecived supervised exercising training at «Local\ninstitution. Both groups demonstrated similar\nattendance, improvements in exercise capacity, and\npealth-related quality of life (HRQOL). This center\npase telchealth PR study provides a useful model to\nJevelop future telchealth PR initiatives and may be\n1 important step toward addressing PR accessibility\nchallenges.", "veleneait LS is @ type of felencalli intervention\nthat involves the delivery of PR content through var\nious communication modalities (eg. videoconferen\ncing, telephone), which connects patients to HCPs\nTelchealth PR sessions may be delivered within a\nhealthcare institution, or to within the patients\nhomes. Telemonitring may be used in conjunction\nwith telehealth PR however, the impact of monitor\ning physiological variables on PR outcomes and\npatient self-management is unclear. Stickland\nct al.™ compared PR delivered via telehealth to 147\nCOPD patients with PR delivered in person at 3\nhealthcare institution to 262 COPD patients. Telecon-\ncltation was used in the initial patient assessment\nprocess, with an HCP at the satelite site performing\nand communicating chest auscultations, vital signs\npulse oximetry, and tests of functional capabilities", "ee i\nJesigned to improve access to PR services, including\nhe delivery of telehealth home-based interventions\nHolland et al\" examined the effectiveness of a\npome-based PR program in patients with moderate\nCOPD. Readily available teleheath equipment was\ninstalled in patients\" homes to allow for videoconfer\nsaci, along with an exercise bicycle and pulse oxi\nmeter. During the inchome exercise sessions, patients\nmonitored their symptoms and 2 HCP monitored the\npatient, thei heart rate and SpO: via videoconferen-\nsng. All participants who completed the S-week pro\ngram had clinically significant improvements in\nexercise capacity and the dyspnea subscale of the\nChronic Respiratory Questionaire. Tsai ct al” con-\nducted a randomized controlled trial of 37 COPD\npatients that compared an in-home telehealth PR pro-\ngram to a no PR control group. This intervention\nincluded telemonitoring, telehealth PR, and tlehealth\nconsultations. The telehcalth PR program included in\nhome virtual supervision of walking, cycling on an\nexercise bike, and strength training. The telehealth\nPR group had improved exercise capacity, self\nfficacy, and mood at the end of the intervention, a\ncompared to the non-PR control group. However,\nclinically and statistically significant improvements\nin HRQOL were not observed, which may indicat\nhat some aspect ofthe intervention environment docs\nsot mimic that of traditional institution-hased PR.\nWhile not PR, Nield and Hoo” conducted a rando-\nmized controlled trial to determine the efectiveness\nof pursed-lip breathing intervention delivered via\nSkype™ software. The 4-week intervention included\nfeedback onthe technique as well as instruction on the\napplication of pursed-lip breathing to activities of\nily living, such as walking. The intervention group\npad a decrease in dyspnea intensity and increase in\nsocial support; however, no differences in functional\nexercise capacity, dyspnea severity, or dyspnea" ]

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[ 19964.05519861012, 80193.41633711476, 33555.5787834879, 51062.355508159846, 118204.70584996045 ]

[ 1, 1, 1, 1, 1 ]

[ "Background: Exposure to respirable crystalline silica particles, as opposed to amorphous silica, ts associated with\nung infammation pumonary fibres (scos, and potently with lung cancer We used Afhmetna/GeneSiter\nmicroaray analysis to determine whether gene expression profes deed in a human bronchial epithelial ell ne\nEAS 28) eyposed to crstabalite ws. amorphous sea parices at nentooc and equal surface aeas (5 and 150 x\n1 um’/em) Bio-Plex ana was aso used to detemane profes of secreted cytones and chemokines in\nsponse to bath particles Finally, primary human bronchial epeheal ces (NHBE) were used to comparatively\nscsess siica particle Induced alterations in gene expression.", "Results: Microancy analysis at 24 hours In BEAS 28 revesied 233 and 631 significant alterations in gene expression\nduced by cistobalte at lo (75) and high (150 x 1am) amounts, respectively (p< G0S/aur off = 2001\n“hang. Exposure to amorphous sica mir-paricles at high amounts (150 x IO\"ym“fen?) induced 108\nignieant gane changes. Bc Plex analyse of 27 human cjokines and chemokines revealed 9 secreted meclators\ni < 005) induced by cyaline sca, bt none were induced by amorphous sca. CRT-PCR revealed that\nsstablte selectively upregulated sveselted genes and cytokines FOS ATF3 U6 and 8} early and aver tne\n2,4 8 and 24 h. Patens of gene expresson in NHEE calle were sar overal to BEAS 28 call. At 75x TUR’\ncm, here were 339 significant aerators in gene expesion induced by cxstabale and 42 by amorphous sia.\nCompson of genes in response to crstbalte (75 x I0hum/em?) revealed 60 common, scant gene\nstexabora in Nowe onal DEAS 24 cat", "Canclustons: Ciistoballte silica, as compared to synthetic amorphous silica particles at equal saface area\n-anceritstons, had compatabe effects on the vailty of human bronchial epcheal cell. However, ects on\ngene expression, ae well ar sertion of eteines and chemokines, asia fered, a the enstalie sa\nduced mote intense responses Our tudes indeate tht fonclogics testing of partulates by surveying vay\nand/or metabolic act is insuicient to predict thar pathogercy. Moreover, they show that acute responses of\nhe lung epthelum, including upeguation of genes inked to inlammaton,cxiative ses, and proliferation, 35\nwell 35 secretion cf inlammaton and proierave mediators can be indeatve of pathologic potetal using ether\nrnmoraized lies (BEAS 28) primary cel (NEE, Assessment ofthe degre and magntude of these responses,\nI Lido ave auggesied bs pracicive In determining de petiogericiy of pureniialy henetul preculsies,", "Nimathy W Peridns:, Arti Shulda, Paul Mi Peeters’, Jeremy L Steinacher’, Christopher C Landry’,\nSherril A Lathrop!, Chad Steele*, Niki L Reynaert?, Emiel FM Wouters? and Brooke T Mossman!”", "Differences in gene expression and cytokine\nproduction by crystalline vs. amorphous silica\nin human lung epithelial cells", "Abstract" ]

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[ 35197.53865566035, 50178.0729336408, 48331.5929143792, 10765.525047026138, 30310.243845144694, 451.39273097892146 ]

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[ "EE EE Ee\neducions in CRD (mean change ~32 mL) afer two\nmonths [31], A simular reduction in CRD following pee.\npdoaal treatment was reported among pallens with CKD\nan Halan-ased study mean change -21 mg) [31\nGraal and colleagues, na prospective cahoe including\n20 healthy people, reported tat succes periodontal\nveatment improved eystatia C levels but had no\ncet on GFR after 3 months (mean change ~14 ml\nmin/.73 a) [32]. In a non-randomised clinical trl\nvolving 40 people, Artese et al reported that periodontal\nherapy sigaicanly improved eGFR among patents wi\nCKD (mean change 42 ml /n/.73 me), wheres tee\nwere no diferences in serum creatinine [33]. A reduction\nproteinuria was obtained following a peiedontal iter\nyenon among 11 patients wah Iga nephropathy bt al\npatents were children [34]. There are substantial shoe:\nromings with each ofthese studies al have small spl\nues, most ave oly ane periodontal therapy session ad\npone were randomised controlled tals. There are als\nconsiderable dillerences in patient populations: dhe sever\nty of CKD among our Aboriginal group wil be grates\nsuggesting the posit of Increased ela af the pee\npdoaal treatment Shortcomings aside, the evidence Su\nfete that periodontal held tay improve renal heath,\naeeetieg n anets saint cided] tel aly nie.", "beens: EP 5 O98) WA ant Be ole Nenete. EF ak eee\ntrated improved FMD after 2 months (absote dference\n)9 %; P=0.02) and 6 months (absolute diference 20\n0.001) forthe intervention group who reeived intense\nperiodontal therapy (43). The degree of improvement was\nsscited with improvement in measures of periodontal\ndisease (f = 0.29, P= 0.003).", "Thene is some evidence that CVD i tafinenced by per\nadontl health. Pion et al. eepocted a diminution i\notidiatina media thickness (eIMT: an establshed\npon-invisive measure of atherosclerotic burden pee\npusly alldated against stlogy specimens. CIMT is\nsociated with cardiac rik factors, and predicts incident\nSrdhovaacala events) [35-39], 12. montha, flowing\nperiodontal treatment among 35 otherwise healthy adults\nean change -0.12 mm, P< O00) [38]. I our recent\nperiodontal intervention among Aboriginal adults in the\nNorthern Teriary, eIMT decreased in those rando\nmised to the periodontal intervention (-0026 mm\n95 % Cl 0048, -0005), P=003) compared to conta\ngroup [39]. The magnitude of the reduction in carotid\nIMT wth peodontalaervenion in the il was equ\nnt tothe effects of reversal of 4 years of aging Bgl?\njer body mass index or 25 nmbig lamer systole Mood\npeste, Mercanoglt and cilleagute provided the fi\nidence that treating periodontal daese results ina\nfunctional improvement ia cardiovascular stats [40\nAmong 5 otherwise healthy patents, low mediated ds\nson (FMD) a measure of endothelial function eepesen\nnga important ery stage ofaherosleroi 41), with\nts presence in coronary or peripheral vessels constituting\nun independent predictor of cardiovascular events [12\nieeuoeed ince el 00 19:7 % & seas peak oocioaecte", "_— ee ee ee ee\nmong a group of Aboriginal adults with CKD and to\nJtermine if comprehensive peviodoatal therapy might\neduce progression of CKD, noa-imvasive measures ol\nrdonaculr disease (CVD) of CKDICVD elated death\nimongst people with CKD over 6 to 24 months, The\nfeailee sees aul Sreatbenes om", "SANE Ee CNT ON IERET VER hohe WHE OE PU\npans ulmatly reeling the perodootal intervention\npenefits (Fig. 1).", "Phe study was approved by the University of Adelaide\nHuman Research Ethics Commitee and the Cental\nAustaln Human Reach Ethics Commits. Writen\nformed consent wil be cbained ffor study partic\nvants before thelr involvement in the trial.", "Mboriganal people aged’ 18+ years who have lived in the\nstudy locaton for 2+ years, and who plan to lve atthe\nrurrentloeation for the next 2 years with CKD (4 on\nalas eGR levels of <6 nls/nin/.73 x? (CKD\ntages 3 5) i ACR 280 mgimmol respective o\n-GER (CKD Stages and 2) W- diabetes plus albumin\nia (ACR2 3 mgimmol)leespective of eGFR), witha\natt 12 teth at baseline and having moderate o sever\nperiodontal dsese wil be invited to takepart in the\nik Padaleedd Ghovias wil be aneened ws Ges UX", "na a\ndisease ina group of Aboriginal aduks with CKD.\npote: The extent ad severly of peredontal\ndisease an Aburiinal population with CKD wil be\nhigh compared wits national evel indiator.\n\nAi 2: To examine the effects of «comprehensive\nperodontal intervention among an Aborgal\npopulation with CKD.\n\nHypothesis: Exposure toa comprehensive peradontal\ntervetion wl reduce progreson of CKD, now-asive\nmeasus of CVD or CKD/CVDelted deat amongst\neen", "Can CVD progression be reduced by periodontal therapy?", "Aims and hypotheses", "Methods", "Study design", "Ethical approval", "" ]

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[ "ee ee ee een ee eee\nectnlogies) and imaged wing the LECOR Odyssey (U-COR\nCamnbehdee: UK) aa previously deserted |14),", "en ee Tapa skin tissues were dissected me\nied in neta! bleed formalin for 8 h Sura sup ad\npan sia samples were acquired wa the Taysie Tstue Bah\nDunde, UK unde ete approval uber T0002. Tsses wer\nciyarited,parfinembeded, sectioned (8) std found on\npert shes VW ternational) Fc stoptlogial ta\ntection weit acarfiird and henutaspineca sane\nruciua denied Gomecake", "ie Sere ineseace ee tine, 2 en Bes anes eee ee\nsis mounted on spertost ps sides, were used. Sets wer\naed cold methaastane (1) ike th 1 (wv)\neu or 15 min at nr epertre, eat Wh 15\nDD att (ab15560, Aba Cambie UK), 1200 a8 at\nLG [34 o 12500 abt nt- ah21175 Aca) primary abo\nes dea 10%) gut sera PBS and nested overnight at\ntons were washed ith IDE (uy) a sear, probed wt\n350 Alena Fla 8 goa sna (Le Technolgies) or 250\nlena For 48 goa anbbit (ile Technologies) fr | hat oon\nernest, washed nd countersied wih DAP (1a PRS)\njt} min Inmunotunrescence was imaged wig he Else £60\npsorscet microscope (ion, UK) Histaogy was aged wig a\ntodas (zeien, USA", "SEEN eee ee ee eee ee\n2 see 5 -CCACAAGCCUGCCCAGUATT-,noa-targeting con\nNCS see 3 UNCCEACUAAACACAUCAATE) and pat\nargetng conta (NPT, seve 5-CCANGCTECTCCCCCECEATT-3)\nRNAS were syothesied by Euan MIG Operon (Ebersterg\ncennany)Selieivey modified Acel™ NAG were syathesize\npy Dharticon Research (There Fhe Scent) Standard conta\ntig (3 COICTIACCTAGTIACAATTEATA'T) and ageing\naD (9 CATEGTCCCTTIACCAACAGTAC) native nd sl\nvery madd (Vio) morphol atsense agentes wer\nS Aannd arenes (uae Ct", "were evaluated in rowing a lable HaCaT human keratocyte\nine expresing lp (Kaz (Zhao. 211 86) Be D0\nswell were plated in 96 well plates ip DMEM(IOE (yy) FCS\nchute for 18h ranserted Io OMEM at seated afte\noacentations = codon) cuted or 20 supplemented\nwith CSt02% (yy) and ineuate or an sonal 34 Cel iad\nty was determined by action of 23M (fal) eesazuia dy\nSigma) and ication at 37 “Car 9 min, Florescencel el vs\njuantifed using a microtiter pate reader (530 nm excitation\n30 remission), taciferate alvy was stayed sing the\nitr OPTIMA plate rade (MG Labtec Aylesbay UX) ater\ning an equal volun of 2 Lucern bier (50 Np\nate p78, 16 mk MgCl, 2 mM DT, 228 Tein X10, 30\nwi iver, | mM ATP wv BSA By Solum pyrophosphate\n2 gl Lira) a ech wel Te ological replat expe\nvate were performed.", "es le en ee Cee Oe ee ee\nslUCAP-2 oF NSCA) of alive of Vivo-MOS (LUCZP-MO. 0\nntl MO) were pepued i ster PS. or vio wansteton\nagent studies, 13 naive sRNA Slutins were prepared i\nene 95. aivietaminet 20 (Le Technologies) and let\nBocellchalenge, rane) 15 pM SRNR solutions were prepare\nSconiins ts ta cnatecinary legtaeciions", "Ror each eatment group (3-6 animnals/group, as indicated). Base:\nine (Le. preteeatnent) 28 acerase at ais were define\nng Vs 200 fo 5 consecutvedays Bowing aging pas\nied lactating NAS MOs al igh ps ceived conta\nSRNAG ox Mos For eich stot ame of 40 dws tad\nnected with 29 gauge acd eral aio anal jects\njot vie cota were jee bah hele and igh pats\ncet actiy was nine desc bea 2h! te", "in, -ya rereelbsredebtsuntebaakihetst sls anlar eens deters\n3748 Apo heli intent (Earn, USA with 30 plo\ntivo elmo sl Je2P2 NSCS or NPT RNAS ig\npat stled Paster pipette. Aquaphorb-TG-s8NA mstres wer\npated by mining Aquapor® healing cates (23 4) wilt Pe\nTero Fier Seni) oa Heal concent of 202) (8\na 30 pn of ative Ace odie SLID 2, NCA oN\nsRNAG Acs bedp bse lucas activity was lined pi\nita topical emulation apatin Flowing frmulaton api\nthe armas were kept anesthetized al SNA penetration\niS i). Each pplication was tepeatd fr five consectve dy\nst actions echinr on naioend or 4alionr Keterisie", "ce ee ee\nhe bits and exci expen a agen othe kta\npanules ofthe satin gras] Ths was done weg human\naga (PC) promoter deve vey acersewanigene FIO\nudp). bic contains 20 kh odie FL poner (-10 I\ncsteum a the FI angen sats agen of 00 a\nhe UTR athe arma co-opt pee deste\ninp flys ene (ig a). Aig copy Luz rans\nmowue was generated nu embcniste ol gee are it the", "eee ee\nsed to characterize ip gene expen pers FL cp\"\nmead eve ston bsteral Syme luninesent acy\nnthe forepaws and hindpaw of hese anal (Fg. 1b) Mach\neskrhserce ey as obsered athe al aso ei\ntd pein eins as lls shaved drs and vent Supp\nmentary Fig Ia) unanaba an gRT- PCR ana skin es\nconfined ha ip aNA was os abun i the dpa and\nhat iuerase protein nas aly detectable By Umble\nNndpaw (supplementary Pg tnd) nly, cwmunotarecence\nSaining demented tht both endagenous mouse Hagges and\nuct wee apposed wn be sowie ps\nFic heap\" tue (Fig hy", "re ee ee eee ee ee\npuna epietm and mouse pa epider ses Supplement\ni eevee tht the a epee ene ten rea\nurine epider tha ast sey modes the seater\nSan an ak tar one ts ace Ee eee", "2.6. Histology and imununofluorescence", "2.7. SIRNA and MO reagents", "24. in vitro luciferase assays", "2.9. intradermal paw injections", "2.10. Topica’ siRNA formuftation and in vive application", "", "7.!. Generation and characterization of FLG-luc2p~ ~ mouse mode!" ]

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[ "Ree rreney pases Despiie high Fong-tenm survives rales In patients with Wim turnice, there I & rape\ndevelop beter prognortie biomarkers in oder to maximize cute whe avoiding treatment aeocated morbidities\nTumorasiocated macrophages have been recently associated with poorer prognoss and increased disease\nprogression in a namber of adult ances We investigated the reatrship beeween macrophages and\n‘iricopetholoocal felors in ths pedlebic sol! wamor", "Seas Tsu micrcerrey Sections Of 124 Wine Sumer Coens Caeined! feo the Coopesstive Humen Teeve\nNetwerk were stained with CDSS, 2 macrophage marker using standar immunahitochemical techniques and\nauantified using dgtal image processing techniques. Macrophage dertes wee coelte by tuner tage, and\n‘vival analyses wee conducted wth avalablecinkcal data, Inmunahstochemistry was pronmed on 25\nsional Wis tumor cates cbt fom the tumor bank at Columbia Univerty Maciel Center and comeated\nwith presence of tumor microvascular invasion.", "Results: Mean macrophage count densities in stage {WV tumars were significantly greater than densities in stage |\nand tumor (p=021, 036) Akfaugh the overall and sear free survival did nt eifer between high and ow\naciophage presence groups acres al stages increased macophage presence was associated with decreseed\ndisease fie survival in patents with stage I tumors (p=0025), Increased macrophage presence may have ao\nrelated with decreased dsease‘fee sural n stage MV patients, but the sample sze was too salt allow\ndetection ofthis diference with sgricance (o=0575) Inceased macrophage presence was associated with tame\nsiciaenider busi 010004.", "Conclusion: Our results suggest that macrophage recruitment may be associated with disease progression in\nWms tum. Quanttation f macrophage presence may therefore be a seul adjunct in vefnng staging\ngore for patients with tage I Wms tumor. Such data might be ueful inthe effort fo recuce the rk\nssrctue ellects eovocioted with onder- or overbestment of this Peoples,", "Keywords: iVilms tumor, Tumor-associated macrophages, Wilms tumor staging, Lymph node sampling", "Mans tumor have Gramaticaly improved (2). With these\nvances, a foc on refining therapy to reduce adverse ef\nfects whe maintaining exellent outcomes has become\nnreaingly important However, an array of biomarker\nhat may be useful is this refinement ae sil lacking\nThus, new biomaker disaivery could reduce bath\nwerteatinent of low-risk tumor and underreatment of\nga tumor, lnting unnecesury morbidity and Un\niesived outcomes in these children,", "oe ae ee a\nignancy, and the second mast common abdominal sli\namar in children [I]. There ate approximately 500 new\nues diagnosed inthe United States each yea. Dut to\nhe development of evidence-based treatment protacl\nand thei elinement by the mulidicplinary cooperative\nvroups over the last 40 years, long-term survival rates in", "a ee ee ae eee, See 2 Cee\nnil bsed upon tumor staging the presence of favorable\nir unfavorable histology, and age, using protocols", "Peter Liou’, Leah Bader’, Antai Wang”, Darrell Yarnashiro*’ and Jessica J Kandel”", "Correlation of tumor-associated macrophages and\nclinicopathological factors in Wilms tumor", "Abstract", "introduction" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2 ]

[ "pede te a acheter dal ack dl ccna har tached oe al tae Reel\nwoman vith a hitor of caine ure wha presented with a complaint of 2 painful ash of 23 months duration on\nner extemites, cheeks, nose and ealcbes She had net experenced ever, weight ls, alopecia, dry eyes, orl\ncers photosestvy, or antag, Examination revealed tender purpurc eruptions wih canal necoss on her\nnose, cheeks, exiobes and exes Laboratory investigations reveled neutropenia, an elevated erythrocyte\nfedimentation rate (ESA, presence of lupus antccaguar, ow complement component 3 (C3) and presence of\nperinuclear ant-neutrephl ctepasmic antibody frANCAY.A rine toxiclogyscten was poste fr cocaine, and\naos chomatography-massspecromeny was poste for lvamiole skin biopsy showed lewcytocasic asl\nind sll yee! tombsis Neri sons ofthe nose ld to ts sltamputation. Large bullae on the ower\nete ruptured, eating to wound infecton and exerive necro tht requied mute surgical\nJebidements When necrosis progessed despite debridement, ater aboveknee amputation ofthe kgs was\nperformed, Once new lesons topped appesting the patent vas dscharged home. THo rmerths later, she hada\necurtence related to cocane use To the best of our knowledge, this nly the second reported case of\nlevamisole induced vasculitis that required above-knee amputation.", "Keywords: Levamisole, Cutaneous vasculitis, Retforn purpura, Leukocytoclastic vasculitis", "Meraluire, anc’ if is also one of the MNst reported’ cases\nwith laboratory confirmation of levamisole exposure.", "According to July 2009 estimates, 07% of the cocaine\nized by the US Drug Enforcement Adminstration\nDEA) i adulteated with levamisole [12]. Levarnisole\nveterinary anihelminthic agen that has recealy been\nhed to vascultis and neutropenia in people with co\ncine use [Sa]. We describe a coctine ser wit\nJevamisle-induced necrosis of the akin oft ne, and\ncalage resulting in nasal amputation, earlobe necro\nsn bilateral above nee amputation (AKA). To the best\nof our knowledge, ths is only the second case o\njvamisoleinduced vasculitis requlrag above-knee a\nmutation to be reported in the English language", "Se ee eee a\nhypertension and asthma presented tothe hospital wit\ncomplaint of a panfl Fash on her extremities of 2\n3 months’ duration, The rash est appeared on. he\nupper extremities and then progressed to her les\nchecks, noe, and earlobes, She denied a history of fever,\nweightloss, alopecia, dry mouth, oral ulcers, pala red\nyes photosenstvily, mall, arrays, joi swelling\nIsphagi, misarages, or blood clots. The patient had\n hvonie history of crack cocaine use and 1 among\nhistory af five pack-years On examination, het it\nign were sable. Skin extmination reveled erythems\n‘xs maculopapular purpuric lesions on her nose,", "seood Macical Can, 4401 Sant Acton Stet Detrit 250018 LSA", "Natasha Purai Arora , Tania Jain, Ravinder Bhanot and Suganthini Krishnan Natesan", "Levamisole-induced leukocytoclastic vasculitis\nand neutropenia in a patient with cocaine use:\nAn extensive case with necrosis of skin, soft\ntissue, and cartilage", "Abstract", "Background", "" ]

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[ 72729.10130688455, 4025.3531481013633, 5141.813480629702, 33421.157264972106, 36219.90884459857, 3899.2055484807934, 4327.026813357341, 39450.428190971434, 453.7018417500076, 655.0555694299983, 750.5927068066085 ]

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[ "wee to examine relationships between vertetion in genes Involved in onidetive strom\n(CAT, GPX, SEPPI, SODE, and OD2) and DNA repair (ERCC2, ERCCS, ERCCS, and\nPARD!) and pre-adjuvant therapy CF in postmenopausal women with ealy tage breast\nncer Furthermore, cumulative mult-gene, mult-plymorphism genetic esk sores\n(GRS4) were caleulited to evaluate the collective effect of possesing mulple significant\npolymorphisms.", "Participants in this condiciate gone seseclation study wore recruited Som a larger parent\ndy investigating the effect ofthe adjuvant aromatase inhibitor therapy, anastrozole,\non changesin CF in postmenopausal women with brest cancer (Render et l.2015). The\nample (N = 219) was comprised of 138 women dlgnosed with beast cancer and 81\nsge- and education-matched conto with no personal history of breast cance. All par\nicpants weee no greater than 75 years of age abl to speak and ead English completed\n1 least 8 years of education, and had no previous history af cancer psychic nes,\nor neurologic dleeaseftrauma a ie of enrllinent into the parent study. In addition,\nwomen with breast cancer had 2 diagnosis of estrogen receptor positive, earystage\npeas cancer (stages 1,2 F 3s) based onthe Tumor, Nodes, Metastasis Classification\nnf Malignant Tumors with no clinical evidence of distant metastases (Edge et 2010)\nThis study was approved by the University of Pitsburgh Institutional Review Board\ninformed consent was obtained from all individual partlpants included in both the\nparent and genetic ancillary study.", "A battery of newropeychelogice Coste wae med te aeons cognitive Sanction (CF).\nWomen with eancer completed copniive assessment after primary surgery but poe to\nation of aduvant therapy. Control women completed the sume cogalivesstesamet\nThe neuropsycholoycl test battery was individually administered to study partlpants\nby trained research nurses. The selection af aeuropsychological ets forthe atery and\neduction of individual neuropsychologicl test data into the eight following CF com\npostes based on explostry factor analyse ave been described in deal previously\nBender eta. 2015}", "1. Attention—Cambridge Neuropsychological Test Automated Battery (CANTAB)\nRapid Visual Information Processing (Robbins eta. 194)\n\n2 Concenteation— Digit Viglance (Lyfayett Cline lasturments Company 1989)\n\nMental FlebiktyDelis Kaplan Executive Function Syste Color-Word Intertr\nence (Delis etal 2001)\n\n1 Executive FunctionCANTAB Stockings of Cambridge (Robbins etal, 1994) and\nCCANTAB Spatial Working Memory (Robbins et 199)\n\n. Psychomotor Speed-—Grooved Pegboard (Klove 1963) and Digt Symbol Substiu\nLon (Weehser 198)\n\n5 Veal Memory—Rey Auditory Verbal Learning (Rey 1954), Verbal Fluency Test, and\nRivermead Story (Cockburn and Smith 193)", "Methods", "Study participants", "Evaluation of cognitive function" ]

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[ 1, 1, 1, 3, 2, 2, 2 ]

[ "SO summarize, among all investigated systems, only\namino compounds have showa the desied, howeve\nmuceobase dependent, bond breakage upon acing\nhe oaly problem being thatthe nulophe water and\nnot the 2- or 3~ hydro groups. The Hhydeowstear\nci containing nucelpde are stable in oth acide and\npase conditions, This diference between «and Bde\nWes Is analogues presous eleuations (dane on a\ndel in which the nucleoside had buen replaced by ame\nhl group), showing thatthe formation a sk membered\ntermediate by the attack of the Peatbonyl group\nhigher in energy (5 Kealmol-l) than the five-membered\ning formed by an a-carboxy grup [22 The proposed\nmechanism, predicting ake instability, in Scheme 1b\nupposted by the fat that only amino derives cleaved\ntthe desited oad, de tothe prefered peotomtion of 3\nsssnslancasalisie cera phesnbomeeee.", "To a solution of a-hydroxy stearic acid 3 (10 g,\n33.28 mmol), ethylamine (673g, 9.25 ml 6656 mma\nTBAL (123 g, 3.33 mmol in toluene (150 mi), beryl\npomide (574,508 ml, 38:3 mmol added, and held\nNOC overnight. After the completion of the reaction, the\nection mint i ttuated with diethylether the pe\nspite formed was washed wit eer and died to obi\nhe desired compound 4 as white solid (7.25 g. 55.70), \"H\nNMR (300 MI, CDCI, pn: 7.37 (my SH, Ae), 525\ng, 2H, CH,), 423 (m, 1M), 279 (be 1H, OH), 182\n193 te, 1H), 1.69 (mm 1H), 1.25 (, 28H, -CH,), 090\n(-CH. BC NMR (300 MHz, CDC, ppm) 8 17541(C =\n0), 135394-C), 12875 (CAN), 12K6 (C-A2), 12844 -C-\nAa, TO6L (CH), 6736 (ACH), 3452 (CH), $205\nCH), 2082 (CH,}, 29.79 -CH,), 2966 -CH,), 29.58\nCH,), 2949 (CH), 2478 (-CH,), 2281¢-CH), 14.24\nCH). HRMS (ESIs) miz Caleuated for CusHas0,\n(MH): 391.212 found 3912869. Cx.H,O,Na (MNat)\nee", "CHah 0.9 (SH, CHa), (S00 MES, CDCI 172.00 (C=\n0), 135:3(C Ph), 12K28(C-Ph), 128.02(C-Ph 127.92\nC-Ph), 6773(C, COM), 66:121C, CHy-Ph), 41.08 (C\nCH,)3624 (C, CH), 31.60 (C, CH,), 2937 (C, CH,\n29.34 (C, CH}, 29.26 (C, CH,), 29.24 (C, CH}, 29.20\nC. CH), 2908 (C, CH), 25.14 (C, CH), 2236 (C\nCH), 13.78 (C, CH). HRMS(ES+) mz Caleulated fo\nCyHixO, (MH): 391.3206, found 391.3199.", "To a sokrtion of Prhipdeoxy stearic act & {2 gf, 6.6 mmol},\nvichyamine (12 ml, 865 mmol, and TEAL (025 g\n65 mma) la toluene, benz Bromide (L14 g, 8 ml\n565 mmol) was added, and sired at 90C overnight\n\nAfter the completion of he eeacton, the reaction mitre\n5s utuated with dathyl ether, and the precipitate formed\nwas washed with diethyl ether (2 50 mi). The residue\n\npained was puted on silica gel column chromatog\naphy using dichloromethane to obtain the desied con\npound 9 (46) a8 white solid (LA7 4, 56%). HNMR\n300 MHz, CDCL) 734, SH-Ph, 5.4 (8, 2H, CH\nPh), AOL (a, 1H), 29 (bes, 1H, OF), 258-2. (m, 2H,\nCH,), 143(m, 2H, CH), 1-41(m, 2H, CH,), 1.25 (s, 24H,", "Fo a stirring mixture of benzyloxy bis(N, N -dlisopropy-\njaino)phosphine (10g 29.55 mal) and alpha-hydeoxy\npenal stearate (5:7 g YL77 mano in dry DCM (100 ra),\nwas adel 05 M Solution of 1H-Tetazole (296 ml\n147 mmol) ACN dropwise at OC. Aer the adton,\n\ncoolng bath ws retnoved and the reacton mite wa\nowed to stir at rt for 15 min. The reaction mixture\nvas uted with DCM (200 ml), and the organic lye\nvas washed with 1M TEAB solution. The eatracs were\nied over NaSO, and concentrated in vacuum and\npurified by fash column chromatography using eluent\n100S0e10-HenaneHOAGTEA (R/=03) to obtain the\nphosphoramidite 12 (7.10 g, 715). P™ NMR (CDCI 8\n149.10, 148.69.", "To a stirring mixture af benzyloxy Bis(N, N -dlisopropyla-\nino) phosphine (1 74 g, 5.12 mmal) and Bhydeoy\nease benzyl ester (8, 1 ¢ 256 mmol) in dey DCM\n10 mL) was added 05 M solution of 1H-tteaol\n5.12 ml, 2.56 mma) in ACN dropwise at OC. Alter the\ndon, cooling bath wat retmoved and the reaction ens\nure was allowed toate at ren temperate fr 15 min,\nThe reaction misture was dated with DCM (150 ea),\nand was washed with 1M TEAB (100 mL) solution.\nDichlocomnethane ayer was dried over Na,S0O, and con\ncentrated in vacuo, and the obtained ail was puried by\nica gel fash colina chromatography using the eluent\n1005010-HexaneEIOACTEA (Rf=05) to get 1335 an\npale yellow oll (0985 g, 61%). \"P NMR (300 MH\nCDCI, ppm): 147.63, 147.07.", "To a stirring solution of diacetone glucose (10 g,\n3842 mmol) i anhydrous DMF at OC, was added\nour hydeide (60% ln mineral oll (wi) total 23 4,\n7.63 mmol) portion wise. Sliving was continued fo\n{hat OC, and then benzyl bromide 55 g, 46.10 ral)\nwah ade dropwise. After addition ie bath was removed,\nnd tring continued cveright a rootn trnpersure\nAu compludien of fen'reaction eacuss of ween Ina", "Experimental", "Benzyl 2-hydroxyoctagecanoate (4)", "Benzyl 3-hydroxy stearate (9)", "Benzyl, (benzyl stearate)-2-y1, N, N-diisopropyl\nshoaphorsmidiee [0-12)", "penzy’, Menzy’ Stenrater3-y', N Nemsopropy!\nshesphorarnidive (0-13)", "3 O-beney!-1.2:5,6-D+-0-sopropylidene-a-0-glucofuranose\n™" ]

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[ 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 2, 2 ]

[ "lescribed at some length in prior publications [99,90].\nThese data were collected a a 50 % 50 nm! ares, Le.\ncach pel coresponds to 1 1 A% the lie constant\nofthe material 6 38 A. The Z positon of the plezo was\ncorded on a separate chanel pric to the Ztedback\nlisengage at the beginning ofeach biss waveform se\nquence, euling in 150 x 150 pice topographic map.\nThe Z chansel spectroscopy image and the average\nspectroscopy signal are shown ia Figure 23, and the\nset ih the top right corner Is the average eutrent-\nvoltage (IV) curve forthe entre image- Approximate\nquisition te forthe CITS map was 8 to 10 which\nsulted in some def, apparent inthe botiom portion\nigure 2s", "region. in the third eigenvector, loading pair shown in\nFigure 2c, the varaton also tore prominent in the\nnegative Half of the bas range where the current for\nell compared tothe smooth decay behsvor in the\nserge IV. Therefore, changes in the cuzent a agate\nia are strong sources of daa valance n the sytem and\nnas bs cuacened to coeweical euoeipcinon se'fes oe", "Re spat’ varighity of the electronic Denavior across\nhe surface was analyaed using PCA [35-8797] DCA\nigenvector and loading map pairs for components 2\nahd 3 are shown in Pure 2be forthe Pee Sey\nCITS data st It is used to analyze the eigenvector\nin loadings simultaneously to examine the changes in\nhe signal fist (he eigenvector here) and Is spatial\nlsubution next (the loading). From a stalstical perspec\nve, we are mapping soures of electronic inbomogenciy\nising Gorn the nepali portion of the 1V eure in bath\ncomponents, as illustrated in Figure 2be. The second\nierector shown in Figure 2 (upper sight corner ise)\nhows an increase in the 005 to V ball of the range,\nshims Con erecute cipal! kas a evaniies sie tn Bs oe", "Ee, Ene, COANE See Ney eee ae\nelect major changes in the vathblty of the data, the\nconnection to the physical properties PCA highlights\nways non-trivial. Ths 6 mostly due to Ue act that i\njormation variance, dhe property wih respect {0 which\nPCA organizes the data, i sensitive tothe varity i\nhe signal, rather than the physical olga of the change,\nThis suggests that PCA allows one to de-olse, de\nsorrate and Vsualze spatial varlabity of the eespoase\npat does aot dielly yi addtional knowledge with\npect to the effets that are being studied, In the ease of\nCITS data om FeTe Sep rests ofthe third compo\nnent, Figure 2, can be legimately questioned as the\njoading map Seems to suggest behavior that is erat\nind typleal of an unstable ip surface tunneling regime.\nthen necestry to use cher methods in order t\nsupplement PCA results and determine the undetying\nsource of varlance inthe signal and its veleance t the\nproblem at hand, as wil be lustated by Bayesian de\nmixing analysis of the local conductance Behavior inthe\nsection ‘Deep learning’ [40.58.59].", "Pigtare 2 Unsuperdsed learning methods, PCA, and means on the FeSele CIS data (a) 150 x 130 poset CMS cata fom the Zchannel before\neee abd the Wiecapy, rer sho th seae Whe ta ct (Seen CA oi fhe TS a oe\nmite he evens (Td PAloeg fe Cis dsstown nae thw een (ne crer", "a rey, | 8 7 Moo\naes we\nees ARS\neee aa 02\ncease pte\na |: saat sy\ni i" ]

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[ 36845.49868074304, 19258.45913223643, 38940.14417378325, 57431.963304971345, 15741.672791252146, 116273.07166003 ]

[ 1, 1, 1, 1, 1, 5 ]

[ "and 2 number of inimnmatory maskers nave Deen investigated as\na natic haiiatems fa comes sutienia Gena", "One such Diomarier, the neunophi~iymphocyre rano (Nex)\nps een associate with reduced survival in many slid tumour\n12.15, Atte ferent wate col count i eulypeslorme\nthe management af ancer pales, NUR i a elaely si\nrd inepensivehamarer to plemeat in out clase pa\nie However is usual pac o oly record tll white Boa\nWA au dite mapa ANC a dat\niting, Aa esl died version the derived NLR (ANU)\npee developed sing WHC and ANC paar ads epoted\nve asia progaatic value to MIR sing a opine\nSee", "2 Hills Sey Na Smeets Ce PgR: eles af EE on\nropes fee sual (PFS) and overall seal (05) a oto\ngeal cancer pints rested with JER inthe SCOPE (Stal\na Chemoradiaterapy io OesoPhaea Cancer wth of without\nitu) ial We als aimed to dently the optimal aNLE eat\nvalue ta this patient group.", "ee Nae ete Senos an) Se ee\nSCOPE! Study was To compute the elle of CRT wh ad witout\nluuiabensurstalin patents wth oesophageal cance deemed\nssl for surgery. 236 pets were cred om cele\nthe UK betwee Fbrany 2008 and Janry 2012. The CHT\nnen cnisted of 2 eyes a inion cpatin-apectabn\nhenaerapy flowed by alter 2 eyees ten eoncrent\nvith cforms external bet adateray (30 Gin 25 acon\nwer Sees) with or wiout 12 weeks of cetatab, The SCOPE\ndered to thereof CONSORT: the al desig, lgily cite\nia and esis have been sepotedpreviwiy [3.15 White\nformed consent was cane rom al ecruited patent Abowd\nne was then in the week or to staring eaten! i al\nints ele to the tl: WBC and ANC were documented 2\nne cane report font.", "A ansiical analyses were pre-planned and conducted using\nata SE Ld We clelated of al dose (actual ttl dase divided\nby prec tol dst) and doe intesty actual dose inten\nse per unit time] divided by protocol dose intensity) for eat\notal dr as messes uf camplance As hasbeen dane ese\nier, patents wo progres or ded during the eaten pe.\nod had denomiaators clelated up tothe pt where the\nporesed of died (16) Lewis for aditherapy we calculate\nof fll proaco dase reclved by each patent and for thos\nho progres ted during the testinent period the denon\ni a ale wp he pit where hey ogee 0", "ea ee\nne brmuda [14h", "aquare tests. Kaplan Meler’s carves were tised to display the prog-\nposi value of the inary ANE variable or diferent yes a su.\nsal measure overall survival (0S). pouesion free Sul\nPS), lat progression fee sural inside te ata vl\n{PTS lat progression fe survival outie the fadton ol\nse (Sd ant renin inal (OS, We\ncid epson yy de or, yesh i\nfe ie they wee lat knw to Be event ee, Unvarabe(\nary aNLR) and mulvaabe Cox regression models were se\natte the proghoatic efecto NER onthe diferente fu\nal ato time points ~ pe treatment (Bseine) ad follows\nwo eles of adaction cheretherapy’ porto dC. The mle\nible model incled natn tote binary dN. SCOPE\nil arn as eto fr ot receiving sgery, sk, WHO pero.\nance status at baseline, dase stage tumour type, ration\nomplance, <span compliance, capeciabine compliance\notal decent covariates ad trestng cet ea shared\nfay. Adaioaly a Cox ode ha teaent-aNLR lve\nred between the two gNLE groups Ia each as, the vai\nhe pfopartona hagrds assuinptaon was checked Us COX\nee eee eee", "ee eae eee ee ey eeeene) Cra thee vase\nom a receiver-apeating thaaceniste (HOC) cave that ax\nmie he penta crt ied fy rein\nThe balance ofthis inary UNLR varable acess prognosi\nCoarectertoses of the SLLWPEL patients vans asarsard! useeg chi", "eee ee eee en) tri between\nbusty 2008 and Febuaty 2012. 257 Rad both pe tested\nWHC and ANE resus collected and were weed in these sales\nThe eda low-up (QR) was 45.2 (359-483) nats or su\nng patents Te dtbutien of ALR wae postely ewe\nvith median of 186 (IQR: 145-245, ranges 075-26.) Th\nOC aa the Sens dd speicy of NLR in eect\nfeath within 24 mane afer andocwstin was perrted\n50 (972) patient (1 patent di at nave a pre-teen NL\naa andre F were oto lwp rar ta 24 oat\nSupplemental materi, Fig. 81). Using ROC curve analysis, he\npial NLR cut value was eae 36 2029 (ses\na's an imacinctey « SPS) Mesiieeeeebeiemene dea oe", "eee ee ere eee\n<2 v= 2) ate shown Taf the ccopatloieal fe\nes ale se, peloeance Status and ta date length\nwere signal associated with pre-weatmentdNLE However\n(using 2 Bonferron correction (p~ 005/11 = 0005), only se\nsoe sielicantly ansociated with aL.", "ee EES ee ee eee nee tea hes\nJemonstated 2 survival advantage for patients with aN «2\n1) Median OS was 36 months (95% 1275-424) fr pate\nith AMLR-2 ad 184 months (95% CL 141-249) lo pet\nvith datiased OS in bath uvaible aaa (HR 124 (95\n\"130-225, p-<0001) and tulvasable analy (HR\n117-229), p 0004) (Table 2} i subgroup analysts, NLR »2\nwas a independent proses lator or poor OS i alent wth\namuse cena (HR = 205, 95% Cl: 1253.4, p= 005\npt he evidence was weak fot adencainomajuderentite\nnus (R233, 9% Ce: 088-729, p= 0085) or whom th\nne size was salle (Supplemental aera. Tate 1) PS\nPFS. LPSo and DPFS were al sgniealy seduced patent\nvith aNLR= 2 in both unvaable and elvanabe soap\nae Gaaeeeenemeanatiaasen,", "Bn ihe analysis of OS according to arm allocation witlie the\nSCOPE! tl dNUR Was no peeve oe eaten let (12\nTaide 3}. Tha anion of cotccionts te CRT wnt nat aneactanea tab", "", "Study design and setting", "", "" ]

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[ "Postoperative chemotherapy is currently administered to\npatents with pathologeal stage (pStage) IB cance, a\nhe efficacy of postoperative adjuvant chemotherapy i\nhese plents has been proven in several global studs\n1-3], and postoperative ofa tgafurural has proved\nMicaious in a group of Japanese patients [85]. A\nesent paints with Stage A cancer often oa rece\nfollow-up care after surgery because thelr outcome i\njenerally favorable without postoperative cheratherapy.\nTherefore, It dificult to determine the elfeacy 0\npostoperative chematerapy in these paints. In atin,\nchemotherapy including tegafuraraell not curtenly\nministered to patients with Stage IA disease, because\nthe cbserved adverse effects. However, entiation of\npatents with pSlge 1A dase who have a high sk of\ncurrence may seule in further improvemsent in the\nneicene of fae eotienta", "eee eet a actor used a the tamor-noee\nmetals (TNM) cassia, and is importance as\npoor prognotic fictor has been demonstaed in sever\ntudes [6-11] In the 7th editon of the Union for later\natonal Cancer Control TNM Chsifaton, published in\n2009, PL. wae seapprased asa pathologies! factor tha\nlistinglaesp-Stage IA from pStge IB disease. While\nvasion at the pleural surface denoted plage 15 i\nhe previous editions, invasion beyond the pleural esti\nayer became a citeron for deterring Stage IB inthe\nth edon. Travis etal. [213] recommended the use of\nlati fer staining to improve the accriey of i\naranimeing", "Despite many previously pebilished siuctes reporting\nat vascular invasion, comprising blood vessel asin\nand iymphatie vessel invasion (h). was a strong inde\npendent prognostic actae for eecustence in pints wit\nStage U primary nossa al lng cancer (NSCLC)\nJesions <3 om in ameter [1011623], was no consered\nactor inthe new TNM clseifeaton. Tie may explain\nchy there so standard pathologcal assessment method\nie eciarienmton,", "———EEE EE ee\nft recurtence rates according to vascular invasion are\nwef In reconsidering the application of additonal\nvostperetive treatment.", "Accordingly, we assessed vascular invasion in patients\nwith Stage I NSCLC lesions =3 cm diameter, using\npematoxylin-cosin (HE), Elastica van Gleson (E¥G), and\nD2-10 antibody immunohistologil talning wo examine\nwhether viselar invasion can be atsssed using HE\ntaining lone In addon, we evaluated whether vse\nse invasion was a useful progaasticfictor in paints\nwith pStage I NSCLC lesions 3 em in diameter. We\nsessed the impact of vascular invasion by using the\nnumber of tnvaded vascular channels at a prognostic\nator and compared its prognostic accuracy with the\npresence of abeence of PL. Furtherinoe, we investigated\nwheter ¥ and ly are independent progoosti ctr rr\nvurrence in patients with p-Stage I NSCLC by comparing", "A total of 467 patients with p-itage I NECLO who\nunderwent a radial lobectomy dvng the period beeen\njanuary 2000 and December 2005 at Kamas Cance\nCentr Hospial were eraunted. Totaly, 35 punts were\nlagnosed wit pStage LA or IB disease Based ona lon\nue 33 cm in dameer and the presence or absence of PL\nobservation period: 84010 das: mean 2292 days); 132\npatents were diagnosed with pStage IB disease with a\numor ameter of 3-5 em lrespecive of PL (observation\nprod: 31-3999 days; median: 19325 day) Al paints\nvere consecuthely enrolled, and none were excluded, The\npatients did ot zecelve preoperaive Leatment\nditional postoperative treatment during the recurrence\nte follow-up perio. The study was performed according\nothe requirements ofthe lasttutonal Review Board\nKanagawa Cancer Center.", "HA study on the signiicance of vascular invasion in\npatents with pStage I NSCLC lesions <3 em\n‘lameter was performed in 335 patent wth Stag\n[or IB cancer based on the presence of PL\n1) Objective determination of vascular ivasion\n\nA comparative study was performed focusing on\n‘elieand PL which shouldbe eegarded as factors\n‘ting the recleifeation of Thun cancer\nlesons <3 cm in dimer at T2 cancer in the\n“AN TNM classifeation, Uniatiate and\n‘mulivariate analyses were performed for\necurence fee survival (RS) peviods with age\nSex PL and vascu invasion a varables\n\n‘To examine vascular lvason, simples for HE\nand EvG stalning and immunctaning with ant\npodoplanin antibody (lone D240) were newly\npreped from whole parafisbloks ofthe ages\n{mor sections, The stained sample were eve\nMedi the sforementoned order to perm con\nprion ofthe fndings ofthe respective stained\nSamples. st, the presence oe absence of vay\nin the ag sectlons was iter n HE sa\n{ng alone: The ction forthe presence o absence\noffen was detction ofthe vasa wll\nfurther ineasion no the vascular lren. Later the\npresence or abuece of vorly was determined by\ntng EG or D2-0stsning especie. The HE\nWea een ee eee atone", "Background", "Methods", "", "Study design" ]

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[ "for nonviolene political activicy, (5) where exvensive\npolitical imprisonment and political murders ate com\nmon, (4) with lege numbers of murder, imprison\nment, and disappearances, and (5) with terros\nexpanded to the whole population (xe Poe, Carey\nse Vazquez, 2001: 658).", "‘Changes In human rights ere generally dilficule ve\nexpuin because the eel of cbservable repression change\nony very slowly; the extent of represion a time eth\nhighly dependent on the level of repression at cme 1\n(Carey, 2010). This is not only because government\nchange thet behavior very slowly, bu alo Because com\nmon human rights measutescaprute broad and therefor\nrlaively sable categorie. For a country to move fom\none category to another of the Poiial Terror Scale\n(Wood & Gibney, 2010), substanial changes is human\nrights conditions are necessary.", "that the killing of a Journalier leads wo 2 change in the\ncoding ofthe human rights condition. As shown below,\nthe overwhelming majoriy of journals led work for\nJacally owned news oudets and the perpetrators remain\nunconfirmed. These caer receive ile attention, and\ndue 1o lack of evidence, governments ate not held\nscountable. To further account for potential problems\nof endogencty, we model the telaionship between jour\nnals Kling in che previous year and repression in the\nallowing yeu, and look at evo, dc, fou, and five yea\naes of journalists killed.", "While using a broad Auman rights measure makes\ndtcting and explaining changes more dificult avoid\npotential problems of endogeneity. where changes in ou\nmain indiaor, the Kling of ouraliss, could automat\ncally wiggr changes inthe recorded level ofrepession\nOur mesure of kil journals isles dependent\nchanges in media report than measures that attempt\ncount instances of epresin, such as data on one-sided\nillings, for example (see Weidmann, 2016)\" I dhe\nilling of journals aucomatilly led coders put the\ncounty in a worse human rights category. the resus\nwould be driven by the coding procedures Given the\nbroad nature of the PTS categories, it is highly unlikely", "See Peso ated Eee Stereo Reece Wee Ce Ore\nwhelming majority of all journalist killed berween\n2002 and 2013 were working in their home country\nExcluding accidents, 938% ofall journalists kiled were\nworking locally: only 79 of all journalists killed wer\nworking in a foreign county. ince we do not identify\nthe country of tesidence of the foreign journalist, the\ncount ako includes instances where the killed journalist\nvas based ina neighboring county. Hence, nol inter\nrational journalists represen large international medi\noutlets. The distinction between national and intern\ninal journalists helps us understand whar the poten\nfects on the information envionment ate in the afr\nmath of a member of the press being killed. While the\nilling af prominent interational journalists is usually\nmet By international outrage, che kiln of local journal\nsts generally draws fr less atention, panticulay wher\na eet mmasin iesconliomed.", "The lek and middie panel of Figure 5 discingutsh\nperween journalists who were killed during an armed\nconflict and those ouside of conic years (as defined\nby Melnder, Petterson &¢ Themnér, 2016). Ae Figure 2\nready shawed, more journalist ae led dating armed\nconflict years, and the level of represion during these\nvears is very high.", "__AS cur study only cavers recent years (afer 11 Seprember 2001).\nwe expect the efit of changer he lel of nent repreion\ni wh hn FT ob ig at", "igure 5. Journalists killed in and outside of conflict years, 2UU2~15", "" ]

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[ "ee ee a oe\nserena (chad ot at aun}.", "Sr ae eee ee ees Cee\nceshavan, 2015; san det Mee eal. 201) have fecused on the\nperobiology of sight i Schzopivena sing paradigns thl\nirecly or unc involve monitoring othe el or seeevn\nformation, Atsctins have been found between por chai\nsight and increased connectivity i the sel teleretal eter\nith the let ssa ding test (Cvs ca 2014), Dee\nnal insight satiation othe inferoe onal yrs teri\naa aod infer parietal lobule dung slerettion (a de\neee a 2013 and between symptom unawareness nd a\nation of many eas inuding the prefontalpartl and en\nreas wih more specie asoktons between symptom mi\nbuon ad lcd eons wi the petra atox a\nral ang, ding 2 slates ask (sa sn Kesha,", "i See Tee eee ee oe\nsal ig pcan tty xing eco\nents with poor a well as preserved cae sight eave\nch other tea soup of hea patient The functoa\nperounatory of verbal self-onitorng fa healy peop i\nHades the ntti gute cree (ACC doseaterl peat\ntex (DLPFC, et ifr frontal cortex, paren, tempor\ntex posterior eaigulte and theif paral came\nlel 20) Puetoning a many hese areas, based o\nes ste of ing in pon (Ct ta 20\n13), apfears tobe vad in isitainng 9 good nigh i\nchiropvenia, Previous studies have consistent shown reduce\nupeornidie temporal labe acy during varants of th\neal sel-mantoring tsk (Fel 2005 serie i 2000\niat ea. 200} bat bo publabed sty o ou wedge\nhs examined verbal self mnarng performance ofthe fuse\nning of the associated ural network ia ela Co heel\naren japerduarvaueg", "ee ee ee ee ee ne anng setfnonitoring er\nsnp sh pen 7 de\nvat, 3015 va de Meret aly 2013), we Iypotesied th\npatients with poor insight compared to thse with preserved i\neh wl dh tess curate seleanonitorng pavers a\nbetan MR espace i the eral el montring neal et\nvon Poo, ut not preserved ight pases were expected\nhaw markedly inpaved performance and perfomance ete\nSay petted mitten incite nea,", "OES > 3° Or ennai. 2:3 Sea), Hoar pee Sneha: potion\ned to follow the task instrctions, and performance dat ro\npor and 5 preserved insight patents were unaalable (i\n\neat tte) dung MRL Twenty healthy putin, seemed\nfo eiclude newopsyeuaie condos ug the SCID (aan po\n\nent version (SCID-NP) and matched, om average (0 the to po\n\nfet groups, forage and ek were tude for camparison pu\n\nposes, with 16 providing useable dat 3, movement artes\n\npnt technical fae) hove eating i the fal sample 1\npatents (9 poor ish. 10 preserved insight) and 11 bel\npateputs were aa incladed ia our eave sty (Saree\n\npau", "rhe study involved GO right-handed participants ih torah me\nanual of Mel sds (034, laut don DSM, 1\n254 dg of sehizopnenia (Structured Chal nevi fo\nps Se, Ft a 103) Of these 2D paints were Pe\nlected tov reserved night a 20 to have po ight ou\nager pot of 7 atin (se resin a ish igh sgh\ngouge) Al coed patente ee ob on sabe es\namipaehone eda for at ea hee month and inthe\nable (oni) puse ofthe fines OF 4 patents inal Sn\ntide, 14 pies (7 oor and’? preened sgh) had 0 be\neee ae eee ee eee en oe", "in Fopigh -riegadercntanin earlier phen\nommatee ofthe Isiate of Payehaty and South London a\nausey NS Tras London, Al parspats ponded write", "Insight was assessed using the Rircnwood insight scale (Bis)\nuchsuod ea, 1951). THe BIS assesses thee ehnensins of\ncl isight (Di, 1990, namely) the presence of 2 ental\nness tens 2a 7), the need fee eaten! ters 3.45 a\nabd (i) the ideatcaon of symptoms 36 anal er\nand) Each Sem i tte a agree -dsagrew or unsure\nvag aie score of 1 for sure ad © or 2 for agre ad\nages depending on whether agreement vi the stateen\ndats god ish (tems eountrbulaned for response\n\neee “Ry sayin bos ecessay” was old, a\nve did no ince any inpatients, Tis yield a maxim\not (hom the femaing 7 sem) i hs dataset stead fT\nvod 1) Suggested a oe out oF 1) athe mn\nood lia ing. addon inal patents sjnpto wer\nese sng the Pstve and Negus Syndrome ele (PANS\nay tal, 57) and predicted was seed in al partipant\nsing the National Adult Reading Test (NART) (Nels sd\n\nang ian", "Nee ea ne aS ine Deserve or poor insight\nrou, ater conservatively by defining preserved insight 3\noreo o above aed por inh a 8 or es out of\nmu 4) wo ensure distinct insight lees in preserved and oo\nugh group (sr. 201) Patents were supervised hi\nompetig the BS The HS ha adequate ternal consistency ad\nstator testes etait tion eal 10) apd HS\nght scares create positively wah sores om iiante\nessures of insight suchas the Scale to Assess Unwaenes\neat Disorders (SUMD: far ss Dat. 200) and the Ex\npanded Schedule of Assessment af Insight (SALE: avd\nSon Sin eames ened. Ee een an, SO,", "AM Participants performed 2 sel-mondoring task (Kumari et at.\nol) whist undergoing INL Pariipants were presented with\nge words on computer scinen (Vale for 750 inert\npul interval 1625), viewed (weting DMR compatible se\nriveze seeded) vn a prismatic moe Hite inthe degen\npu ea they aid the scar, and were instructed to ea\nach word sad The patipants speed was wansorsed el\nine tough a soflare roganime anda DSPIX dal eles\nroessor (Power Teal. Caer, USA), aplied by\nSeer pend cou ad ead ack ah pemuiaic to", "", "21. Participants and design", "", "2.3. Creation of preserved ard poor insight groups", "24. JMR! paradigms and procedure" ]

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[ "piesa iin ohne cl hella iil hin ea da\nand renting eveence demanstates sgnfiant neutnal damage as occurs and is azacted with permanent\n{unctionalimparment. Cuent MS therapies hae med ably fo prevent neuronal damane, suggesting 2dtonal\nneuroprotective therapies a needed Compounds tht activate the NAD-dependent SRT! deacejase prevent\nrewonal losin an uteimmune-medated MS model bu the mechanism of ths efi s unknown, and itis unclear\nwheter ST activating compound eet slr effects In demyelinating dene nducedby ether etiologies We\nmeasured neuronal oss in CS7BL/8 mice inacubted with a newouepc Svan of mouse epatts wus, MHVA59, hat\nchuces on MS a dhesee,", "ee ee ree Teen am Ui ee) ee Anpeeg Sia ed eee at Sere ee Oe\nnerves and prevented neuronal loss duting optic neurts, an inflammatory demmyeinating optic nerve lesion that\n2ccurs in MS an ts animal models, ME-ASD induced neuronal lose wae atsocited vith reactive oxygen speci\nOS) accumulation, and SETAWOM treatment significant reduced ROS levels while promoting increased expen of\nsayin invved in rtochondal uncon and reduction of RO, SETAWDM exerted lar protective eects in EAE\nscikdl cords with decremsed demyelination,", "riage lpn dieijl-thset idle t chariot anaes least ncaa bdehclbes to plmcee prtchdcileh ca A\nAgee similar to thei efacts in autoimmune-medated disease. One mechanism ofthis neuroprotective effect\nvols ieeasng mtochondil bogeness wih reducton of endive sess SRT! activators represent a potential\nnewoprotective theapy fr MS Understanding cormmen mechanisms af these eft mn stint dsease models il\nheip identify targets for more specific therapies.", "Keywords: Demyelinating disease, Mouse hepatitis virus, SIRT], Neuroprotection, Oxidative stress, Optic neuropathy", "eTO), SUBBESTING additional therapies With neuropro-\nective besefits are needed.", "weultipre sclerosis (VS) is an iniammatory Cemyelinating\nsais ofthe ental nervous system (CNS) [] Sign\nnt neuronal damage aso occurs ia MS, and cores\nvith permanent neueloge dysfunction (26). Cueen\ntherapies reduce the inflammatory component of MS,\nbut thetr ability t0 prevent neuronal damage is limited", "_Wihule evidence suggests M's is an autoimmune disease\nsgainst CNS myelin, the exact etiology s not known\nOther evidence suggests. genetic and. vita mediated\nriggers [1], Because the eolgy is unkown, several MS\nlal models ae used, The most common MS model\nperimental autoimmune encepalomyeliis (EAE) i an\ntokmmune deven CNS demyelinating disease [12] that\nko exits neuronal damage [13-15]. Another MS model\ninduced by infection with neurotropic stain of mouse\npeat vius (MH), MHV-AS9 (167. Whe MV”\nA59 induces CNS inflammation and demyelination simi\n0 EAE, the etiology is distinct, lwoling direct neuronal", "sont tcieses EET isbn Ponies baeemaee Reais ier Beal\nes alan Oth Nearer Ca cor, Nata Ye Bo\neprint pei Shae Heise any a\nwoking erent Umer\nMotecuiar Cpthalmalogy, Siar Chance |", "Reas S Khan’, Kimberly Dine’, Jayasri Das Sarma* and Kenneth $ Shindler”", "SIRT1 Activating compounds reduce oxidative\nstress mediated neuronal loss in viral induced\nCNS demyelinating disease", "Abstract", "Background" ]

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[ "Backround: To evaluate the Importance of oral glucose toferance test (O17) In preclicting diabetes and\nsarovarcular eae inpatients vith and without Metabolic Syndrome fam 2 population treated ina prima", "perez ten-fold latne deca dee laa sacl la nas govlans-seieak Feariciealle dled\nprimary cate uni of Hospital de Clinicas de Pot Alegre. Partipants underwent a 75 g OGTT. Metabolic syndrome\nHefinitcn wen based on the crterta of IDF/NHA/NHLEG 2010.", "Results: Farticganis mean age was 61-12 years (males 35% whites: 67%), Of the 148 subjects Inchuced, 127 {36%}\nwere flowed for 3614 months, 21 (4) wer los. Subjects were classified ino four groups based on baseline\nOG: 29% normal f= 43), 28% impaired fasting glucose (FG. n=42), 20% mated glucose tolerance (GT, n= 38),\nand 173s dabetes (1 =28) Metabo syndrome prevalence was over in norma group (23), termediate in FG\n(2) and IGT (658) grougs, and higher among subjects with dabetes (2% P-<O00). ncdence of abet\nereased along withthe Sages af lucose metabolim disturbance (norma Oi FG. 16h IT: 28% P0008) No\npatent with normal OGT developed diabetes, regardless metabolic syndrome presence. Dabetes a bassline was\nthe major determinant of cardovasculr seas cccuence (norma: 3, FG. IG OX, cabetes: 24 P=0001)\nmn Cocregresson analysis, ony the 2 OGTT rests were assole wh chabetes (R103 SSC) 101-106 P\n20.001) and cardiovascular disease development {OR = 1,013; 95%CI 1.002-1.025; P0024).", "Conclusions: In this sample of subjects undergoing diabetes screening, the OGTT predicted diabetes and\ncardiovascular disease more effectively than the metabolic syndrome status.", "Keywords: impaired fasting glucose, impaired glucose tolerance, type 2 diabetes, metabolic syndrame,\ncm lioweciat Gwoe", "paired Tasting glucose (6G) and impaired glucose tol-\nance (IGT) assed based om glucose level t Esti\nand alter a glucose challenge (oral glucose tolerance test\nOGTT) [i]. Both condilons are associated wit\nnested rsh for DM [5,6]. Predlabetes i a rs facto\njor eardioascular evens [7] and ecenty, IGT has ben\nstoclated with microvascular disease, retinopathy and\nmicrotbursinusa, conditions tadilonlly ated to\nDM [8-13].", "Hyperglycemia is a well-known risk factor for micro-\nund macrovascular disease [I] and Is associated with\nnereased morbity and mortality [23]. alterations on\nucote homeostasis Rave been described preceding ds\nbetes melts (DM) dlagnonis, and are known as \"pee\nliabetes\", Prediabetes comprises two subcategories,", "Metabouc Syndrome (viet), @ cluster of cardhovascu-\nar risk factors characterized by insulin resistance, ab\nJominal obesity, dyslipidemia. and hypertension, i", "Camila Furtado de Souza’, Mérlane Boelra Dalznchio’, Francisen Jorge Arsago de Oliveira , Jorge Lutz Gross’\nand Cristiane Bauermann Leitso”", "Glucose tolerance status is a better predictor of\ndiabetes and cardiovascular outcomes than\nmetabolic syndrome: a prospective cohort study", "Abstract", "Background" ]

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[ "Ben Opa anes ile eee eee of GU etree Pe a ee ee\njaht onthe mechanisms tat regulate entry of clay prtens into the compartment Here, we focus onthe\nmechanisms tht regulate clay en of cytosolic molecules. Studies have revealed a sze exclusion mechanism fs\niar etry tha simi othe barre 10 nuclear enay Active impor into the clay compariment ivoles\nnucear taffcking components indoding imporins, a Ran-guanosine wiphesphate gradient and nudeopens\nTogether tis wotknceates that nace and ila share molecu, sructral and mechanistic components that\nrequiate import into the compartments.", "Keywords: Cilia, Ciliary pore complex, Flagella, Nuclear impor, Nuclear pore complex, Nucleoporin, Ran, S@e exclusion", "[ae Sn eee ey ee\n“liopathies [3,4].", "ape Soe ae eres Ss ee ee ee\nons and maxpholoyis by compartmentalzng celular ac\nives within toplagealy distin organs such 36 the\nmelas, mechondsion td endopleamle reli, Re\nrent work has suggested thatthe cllum ial « specalized\npanel. Cla aed fagela are microtubule based orga\nes hat peotrde fom the cl surice and func ne\nlr entity and extocellaar sensing. For example, ati\nsla (® Mage) beat to move mucus up the repo\nvat tablish efght asymmetry inthe enbeyont nde\n2d peopel spe, Non-mnotile cil, bio called primary o\nsensory cli, were once belleved tobe vestigial organs\nwithout complex function. They are now knows to ac\ncelular signaling antennas” responsible fora vty\nof functions including olfsction in olfctory neurons,\nphotoreeption in photoreceptor alls, mechanosensing\nid flow in Key epithelial calls and responding t\ntac signals ike Hedgehog, Wat and platelet\nJerived growth factor ligands (reviewed in (1.2). The\nmodern View of peimary cla a8 sensory antennae has\npeen deven by recent ndings that defects in clay\nformation, function and/or signaling underlle a group", "An important Characteristic of the cium of iagenun\nthat the organelle protrudes fom the cal susface such\nhat the clay membrane is continuous with theplsmna\nmembrane and the invaclary space is exposed to the\ntowolie space, Ths rates the lnportantquetion of how\nlary components ae targeted to andlor retained inthe\nnganele For example, suueturl components such a\nhe outer dynein arm and radial spoke complexes of\ntile cia are assembled inthe cytosol and teficed\npecially tothe eum [5 In addition, the enic\nment of many membrane and saluble signaling factor\nthe ellary compartment ls required for proper mati\nsnd Sensory fanclon. For eampl, nthe Hedgeog path\na, eaficking of soluble Gi ranseripon factors though\nhe clay compartments requited for proper Gi peony\nis and sabeeqaent transcriptional output [78].", "Eairy into the cHBFY Compartment takes place at a regon\ntthe ae ofthe clu tered the tration zone, where\nhe baal body tansions into the axoneme (Figure 1)\nstructurally the easiion zone i characterized by trans\njon fers and ink structures that nk the basal body\nsoneme to the membrane and by manbrane potions\njermed the clary necklace (reviewed by (9.10) Figure 1).\ntwas hypothesized that the transition bers might be\ncomponents of 4 fagellar/cllary pore complex (CPC)\nthat controls the entry of cillary proteins ina sleve-like", "Gimmie", "H Lynn Kee and Kristen J Verhey", "Molecular connections between nuclear and\nciliary import processes", "Abstract", "", "" ]

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[ "Soe wy nm et ee ee es\n12422423), eyeln-dependent kinase 2 (CDK2; 1218), and etn\n(TEN, 24812)\" Signa or migerive linkage with knee\nmuscle sengeh was found fr the rons comprising COKE\n(LOD 34, p=D0000, Ry (LOD 274, p= O02) and IGF\n(LOD 2.6 f= 0.0002),", "Pselpepnirh-g dvcherhainenahenmel. -amuenirnetiag haan\ninkage with muscle strength choracteisties We therefor\npored a penome-wide nkage sean wing 6008 SNP marks,\nining to tenly gence regi haboutig canine gnc\nhae ete variation in MBA, metre torue ad the tongue\nsae uscloadile oF tha tee ieee oa ronan,", "ae gn an Ruan Dhded aoeae tik, conne cnniettn uclees\nnouring ase of eandate pene, with some overlapping resins\noe dierent eng characteris, rugerting plastopi fee", "Sr ee cee Peat goa oe ae,\nand ethical committee of the Katholieke Universitet Leuven\nfoe partipation, the pupote and prcedurs ofthe study\nwere ehpsined in deta nd the sujet gave thie writes\ncea commen", "SP easeain Ai bcaiillcn nase Ghlasind cide amin ont nt onans\n36 years in 105 famuies wee selected this group was composed\nof {3 quads, 47 toe ad 45 pis of brothers tenting 20\npeirwisesmnpssons The sig pis wereld tse on\nheir lvel of ducrdanc fo different suengehphenctypes, The\ncenitme proces and ane cazatetiea have bees\nieecribed in detail previoualy.*", "* Ceeaie’ overview oF ie ant ropometrica’ ane _musce\ntrengsh measurements in the LGIMS projet ean be Found i\neyancral™ =", "cee eee Lo Was estimated: Daset on ehe circumier’\nence of the mid thigh corrected for skinfold thickness atthe mi\nigh", "Ne Ho TERE REE MRE Eh IBN (skinton’ Ehickness ric\nthigh xn/10)3)/{dxn),", "od are deaiked ip nee belek\nand are described in more detail elsewhere.”", "or 3D seconds In secordance withthe torque length relation\nhip of» mule, optim stengeh is genested st loge\nac length-that i at an ange of 60\" or Koos exten\nGuadsceps) and for ne Besson (hrstringe). The torque\nength elstonship for knee feon and extension a\njute by ealelating che ratio of true a the joint al\nwhich the lowest meta sometc fre ts produced (0 o\nion, 30\" for extenson) ever trque st the ut angle with\nRe ighest mean wort ace output (\"for fleion 60 or\ncomstoay, muieiotied i 10m", "Sain, Mec Wa TIT aan saad ce es\nRonkonkoma, New York, USA) was used to asses. the\nmaxutn acmetic and tonqueingch knee sragth cara\nsteer S10 minute warertp prod en at ergometer\nsds and ight stretching exes sults were potioned on\nhe dynamometer, ‘ollowsng the manufacturers nerutone.\nAnatomical seo seta fll extension of the hace ad the\nation sus of the jot was aligned with the mechanical\nothe dynamometer Two sometne and fur concen\nutensil le preceded the seas tet, to allow familar\nation with the wtag procedure (angle, eye of sation\nloc). Maximal uametne knee teen was mcsuted 3\nto angles (20° and GD). At each angle highest toque value\n(Nn) Garng a” Gaecond annctne contraction of thee\nsedans Stine and deaglon coneueicue qruis musta", "isometric Hexion torque at 6U'/isometrc torque at 30°} x 100.", "ee ee\nhe level of dally physical acuity and more specially\nbeet! sports partepation in the Spore Indee. Descriptive\natisis tnd phenotypic cordatons besween the diferent\nregth characrats and covaaes wee cated ing\nSAS ¥79.1SAS Institute Inc., Cary, Noth Carolina, USA).", "Sey Wwas extracted’ using the Svemagic SNe mood xi on an\nwutomatedChemapie Magnetic Separation Module |\nCChemapen, Bserweles, Germany) anda. Muliprobe |\nTerkinBimer, Waltham, Masachuses, USA) robotic sation\nAn Onagene sla kit (Cencrek Gente, Ottawa, Ontai\nCanada) was povided to aings who wer not slo deliver\naod sample DNA fom these salva kts war extracted\nSusman ths wsddeleas of cha eneutoniane", "aotyping, The pane includes 6008 SNP markers estribute\nnly actos the genome. The average and median inte\npeeh marker wee 462K (0.654 cM) and 296K (0.38\nexpectively The ler interval between size geno\nel marae was 802 eM on chromosome 8 The fin\nines were typed with the Maina BestationSIOCK,\ncso wi the manufac sanded coer\nons. The genotype stress ate was 99.6% (8 SNP xe\nolor ga or htt oe steiral SNPs\naed fer tanta tralpece", "ee\nhe varsnce-components (VC) analysis procedure ia QTDT.\"\nThs atte includes coenmon environmental vation i\nition to the additive genetic component, because thes\nactors nat be erated wth sling pars only. Hees\ncued to epistack keckshnicn,", "Sparel ecbis-elberiaenbeiiiy’seabireieaiieetenie. Sell sourenel cama\ntimated Using the Genetic Power Calculator based on the\npertablty sates estimated sp OTDT (assumptions: 00\ntive QTL variance 37%, common reidl shared variance\na, us eae, malic! conceal euers a aces", "De enn tat ee\nM sutosomer using the revised Haseman Elston, regression", "METHODS", "Subjects", "", "Body composition", "Niusche strength", "Daecke Sport index", "UNA collection", "Wenotyping", "Statistical analysis", "enitabibty estenatons", "Power analysis", "LINKage analyses" ]

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[ "The Free Radical or Quidatve Stress Theory of Aging Is one of the most popular theones in aging research and has\nbeen extensively tuded over the past several decades However, recent evidence using tansgerchanockouk mice\nhat overexpressor donn-egulate antidanterzymes challenge the veracity ofthis theory since the animals\nsrw na ineeaee or decrease in Mspan, These resus serouy call info question the rle of anidative damage!\n75 In the aging process in mammal. Therefore the theory requis significant moclcatons if we are to\nunderstand the relationship between aging and the equation of oxidative sess Our aborstary has been\nDamining the impacts of thioredoxin (Ta) in the cytasl and mitochondia, on aging and ageelted diseases\nOur dita from mice tat ae ether upequsting or down tequlating Tx im diferent cele compartments, that\nhe esol ar mitochondia, could shed Some lighten the fle of axe stess and is pathophysiolgical\nsecs The results generated fom cu ab and ethers may indicate that) changes in oat sess and the\nedox tate in the cyto, mitochondria or nuceus mgt play deren os in the aging proces 2) te roe of\ndative stress and redox tate could have diferent pathophysogical consequences in diferent isueseels or\neammple moi vs postmatc 3) cxitive sess could have differen pathophysalogial mpacs in young 2d\nad animaly and 4 the pathonhyslogi! fle af endive sess and redox safe could be controled tough\nchanges in edaxensitwe sqnalng, which coud have more diverse effects on pathophysiology than the\nscumulation of ondative damage to vanour molecules To citcaly test the role of andatve stress on aging and\nage-related diseases, futher sy requed using animal models that regulate oxidative svess level ferent in\nsch cella comparment, each tssue/ogan andr at ferent stages of le young, middle and ald to change\nredox sensitive signaling pathways,", "Keywords: Thioredoxin, Transgenic mouse, Knockout mouse, Oxidative stress, Cancer, aging", "oe ee © ae ee eee\nthe age-related increase in pathology and the progres\nve decline ia the functional ficiency of varius cella\nar processes [1-3].", "ee SS ee ee ee See\nane of the most popular theorls in aging research and\npas been extensively audled aver the pest several dec\nes, This theory s based on the fet at els exit\nchronic state of exidative stress resulting fom animal\nance between pro-oidants and alioidans. Because o\nhie imbalance, which occurs as a consequence af ar\nsbic metabolism, Its proposed that an accumulation of\ndive damage acura with age in avaty of macro\nmolecules within the cell This steady state of increased", "at ee ee ee be Pee Cae ee\nive tress hypothesis of aging is the lange amount of\nfata that has shown an age-elted increase of oxidative\nJamage ina variety af molecules (pds, proteins and\nDNA) in organisms ranging fom invertebrates to\npumans [14-10 Another tong line of evidence comes\nrm manipulation studies that increase Ispan, Cale\nstition (CR), which extends expan and delays gig\nvarious species, has buen shown to reduce the level\ndative damage in tas as measured by a decree in\niposcin (11-13), lipid. peroxidation [13-18 protein\nidatio [1019-23] and DNA ouidation [24-26]. Subse\njuently. CR mice have also been shown to be more", "Use © Flores’, Melanie Ort , Sere Dube’, Gene B Hubbard”, Shula Les\", Adam Salmon, Vigteng Zhang’\nand Yuji Ikeno!245*", "Thioredoxin, oxidative stress, cancer and aging", "Abstract", "", "Oxidative stress theory of aging" ]

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[ "ahume. and te Cast per dose of nese capital investments was\nely distbuted over ten yeas. Commas, Wansport. cn\nigh a shed eal syste costs were excluded Up cn\nlation with local experts. we sessed our ital estimate\nclude on al of personnel costs The atonal hat the ez\npected tobe much iawer than the average aor cot pe doe\naang & lower, bur tl consersnve, bo einate ys 8 el\neco a ley 5994 We ee hs Vrle he", "he home for darshen 25). However, the 2014 Demogiapi\nelt Survey reports tat approximately 36% of chen unde\nie eceive eaten! fom a ayo feral prover 0) T\ncount for the populticn that seeks care iformaly and t\napuze these foal costs we slleentite cases iat thos\nte feceve fotal orion cre and 46H of those sean\nreament veceive formal eae, thi implies 408 (is, 036/038)\ntthoveseking cre wil secive care in facty. Te retain\ngat kr lek cea rl eng Ts\ntermine the poplin tht ack ae for rt", "ee ee ee ee ee ee\ntn the as of nota tral outpatien ora inate\nae Providers (eg he goverment wl nc oss for formal\ntpalen t feral inpatient cate We tess nora a\njn oupatient case fo household and providers and then\nread an diteass Inpatians caves for beusabcite and peeves,", "ated om ase a apd sumo $1.17 [31 Hausa cst ass\nted wah foal open ete af estiated om the se\nrc and ttl $1.30 These neal sd outposts\nneat lal SL. or oma outpatient ce based estat\nposed and provider ots Das et dont ma hs isin\nfail double ouning we allocate css by category a aca\nne othe bows ot preter sh atempl adequate\nestat the costs borne By ach stop. Estiates of provider cs\nay be conservative sey are gathered rom stud of heel\nredial expenditure. Any provide oss ha ze na passed of\ntint wi be undetestated hu woud ave 8 snl pt\nests While ineret, our estes ae inthe rage of thos\nported in Rhogas ef SL ncesing or conden aout et\nmeee [}", "SO a ne eed et os Acne eee\ntal $51.2 or households and $11.41 for providers 35) Inpatient\nect ets Sich as lst wages Al cost inputs were adie\n2016 USD sing the period average ofl exchange ate ad th\ncenonmar pric’ facies (94351", "Wie poset Reve epeerine Saee commepens is Mave atin\nora estimates sectuding alow estimate high estate, an\ndpa estimate [2 The senaios ar dtaed i Ts\nnd ulsteate the poet of oats vacation overt yar\npening it 2017. Al model inp ae onset across the ce\nasios wth the exception of the case aay ate fr sever ds\nase. Vaition sh the ase aay ate used to ence pe\nacinton rts marta inthe model Ih ea cent we\nsea vac pic per dose that cous fora Gav subsidy a\ncreases ve ne fn 8016 2017 to $0.58 by 2028 We\niis tas al coat or uneaciae en tp ee Gee", "sae eatin lath mt ey cr ee mar\netd inthe high metal steno fo S1A/DALY averted i\npic of $2.19 pet dase the cot DALY rats substantially igh\naging om S6ISIDALY averted i the igh aray scenario\nSALT aver ine low ral sea Cs er eth", "nso ote, Das etal 0 not dstiaguish costs by dlscaseseverny, We use the", "", "", "", "", "", "", "", "", "" ]

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[ "mn age later nae nnd lietelee dea ae phd\npoodly distributed, The NMICPs were previously reported a\nand plant Embyophyta) restricted (Cis et al 2013, bu\npete ne idntfed hemologsincharophyte algae upplemen\nary fig S1A, Supplementary Matera enn) Signi\now sequence conservation between NMCRS frm even cl\nly related ata suggests tat, sar to NUP, NNICP dt\nbuon maybe boc, but cent ols are unable o detec\nsy sch putative degent homologs. The major ue wt\ndentiying distant homelgs of cael preter in genera\n= that certain amino ace ae favored depenang onthe\npositon within the heptad repeats of the aol to enable\nhe coledcol interaction with the other chain)\nconsequent, ther sa cera eel of sequence sin\nsen between coiedall rters with presumed indepen\ndent orgs (evalestypkaly between 1E=04 and 1E-07\nThus proteins that diverged to this evelofsimiary cannot\nsamc deteined a homoge, even they were\nact cos related. Furthermore, coled-a laments are gen\naly prone to rapid evolution (Fler-Aubusscn 2003; Gouk\ntal 2011; Holden etl 201), ely du to fw interaction\nwth ether poten watin a cl leury-usson 2003)\nwell a5 the lovesequence complesty within eoled-<ol re\nons. Asa reat, coled<ol proteins belonging to the am\namily often delay smiar lve of divergence as that be\nteen proteins frm unrated fares and this makes iden\nfeton of stant homologs of any calc pron\nscl tack Tha tse concems both NUP-) and RAC\nney ack the dsincive or eriminatoryconered da\nsupplementary fig. S1B, Supplementary Material onfine).", "vr contrast, mevazoan lamins possess 2 high clsunctve\nnina lamin tal demain LTD) that bears an mmunedlob\nin-tefld (echat ea 2008), Our expanded trate ho\nnology earch fr amin enifed sgnfcant its ra mc\nreader aray of potsts than prevusy. Altogether, wx\ncurd lan homologs in 12 dstnet eukanete lineages\nweazea,Choarflageltes, Flaterea, htyospores\ntoss, Rhizaria, Hapopintes, Onofagelates,Biosce\nida, Hyphochyteiomyeetes, Oorycetes, and Ochophyt:\nfig, 1 ard supplementary table, Suppementary Matra\nolin) Al canidates were veri by reverse BLAST aga\netazea and retured lamin as top his. By usr ether the\nhal amin roth sequences or pectic drain ar ques\nfound that al hamlogs could be ened using the LT\nSoman alone, whie some horaogs ales obe four whe\nete with ist the od domain and other cleo pote\nere equenty dentified as unspent. Ti suggests tha\nputatie lin homologs with cvergent or no LTD may be\n‘hallenging to identify.", "ee\nregjons OF ctherlmin-tke features and hence can be ex\nclued as dec amin relatives. Nevertheless, this aes the\npesty that the TD domain descended rom prokaryote\nSet ith an ancestral cosedol protein nthe couse\nearly eukaryotic evolution to produce the eukaryotic lamin.", "ee eg ee eee ne\nn avarey of bacterial rete, Including enzymes that ae\nSealy not amins, but were retieed by searches using the\nTD as query. Poin wth uch an LTD-ke domain are pre\nsent ako in several eukaryotes (supplementary table ‘51,", "P* BIYIOGENENC lee OF entined lamin nomalogs marors ie\ncurent ew of eukaryotic evolution, tse deve from py\njogeetceconsucions sing concatenated dat from hu\neds of proteins (Burk 2014) (ig. 1). Such a coineers\ntopology between species and gene tees & sang evidence\nfor eral evolution, suggesting that MGT eensare une\nThe most prsimericus interpretation is dec descent from\nsn ancient eukaryotic lain. though the oot poston wth\nhe eukaryotic plogey is uncertain (Burk 2014) the mos\nfavre unkont-bxont roan, supported by recent sty\nDele eta. 2015) suggests a pelas eukaryotic common\nzncestor LECA amin ong as homologs ae present in both\nareal", "Sy comparing homologous farm sequences, we a\ntempted to reconsrct thearcestal lain i 2 and supple\nmertay fi. $2, Supplementay Merl ening All mac\ncakaryoic Ineages posesng dentate amin homologs\nako possess representatives with wellconserved domain a\ncteture, retaining all sequence mois pica for metazoan\namine CDK! phosshangation ste, monepartite nicl\ncaizaton signal (NS), and a aa prenation motif (Oech\net a 2008). The lee of consenton between these wel\ncatered line ther underned by coneened intrup\nfo the predicted calecal regen (upeiemensay fg\n2, Supplementary Meal ening. The ancestral eukaryote\namin therefore pected ery smlar tothe ype mis\nof metazoa but likely pasassed an addtional heptac\nrepeat intrusion (LO ig, 2 and supplementary fg. 52\nSupplementary Matera one). Te lanins of Comte,\nDinalagelates and Haptophyes are mest smi to ths ar\nmil ochtechure,", "ne conservation of precacted! secondary structure, even in\ndotant lamin homoog, implies conserved uncon. Genes\nook are Smited or absent fom the pros where now\nmins were dented so we tured toa marnalanhete\nslogous system. We selected two candidate lami rom the\ncleat elated to animals for which an entice mRNA cong\nsequence was avalable and expressed them as Nerina\n{aon wth eGFP in HER2O3T cle. One homolog sled\nvas rom Symbiodinium gorau, a Diotagelate, and the\ncond trem Phytophthora infestans, an Comyeete Both\nproteins were detected as flamertous seucures within the\nrules (ig. 3). The lamin ofS. grea was preset as long\nlaments = um) concentrating tte rear periphery. The\nfiarnts of the P. ivkestons lenin were dhorier era) vend", "Evolution of Lamins" ]

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[ "Recaro Tine Cepectie Of tis Sialy wes tO eauete the Inpect of Semele Seeks FA) On pants\nTmunity and Idendly deewse and ther factors such es fetigue thet most Influence senal reetiorshice,", "Set A SpeCEic prelrte CEMETTCNTIIEE Wags Sent (6 28 members ote French patient psocisicon (ANDAR,\nQuestions related to demographics, disease satus, quatyof le (tty ESD), pan, psychological satus (eos,\nalge and emotional and seal reatorships. Te solat the impact of RA an aterpt was made include a\nanched semple from the general population,", "prarwal installer. Arsslelt-sepstteenpellateeridiendesesetsehc lidedbeadlck es Uhre.» phases echedar erik de eee Aaa\nherefere be considered with caution. The two groups were similar in terms af age, gender stibuton, ving\nconiions and isases other than RA However, patients Scoted worse fr global health mond fatigue, had a\nover uty (055 versus 088). Contas were more acive sonal 63% versus 6385) 1m partculat women (71%\nrss 6050) Age, gender, ving alone, pyseal function and mod were significant predictors for being sexual\nsctive for patients for controls, age and overall quality of ie (utility) were sgnificant predictors.", "Sree rn ees Wat Be rene © ie oe Tae 200 Deer Seta, Dies ene weer ete Sie Ds\n© quantify the prblem Our study highlights the negative impact of RA on patent’ semay, and tigger the\nauction frow be Include ths expect Im care.", "Keywords: Rheumatoid arthritis, Fatigue, Quality of life, Sexuality", "Se ee eg a ee et aeenaes\nwere quality of le (QoL) measurements were Incded\nclini rl in the mild-ighes [1], Today Investig\nng ptlnt-eported outcomes has become standard i\nlineal reearch and a numberof meanies are rutinely\nmncluded in trials [2]", "ee Ce ee, pee ane econ\nimitations have been shown [3-5], control of thes\nymploms may not fully estore all plyseal, social and\nmental aspect of QoL. Studies in France on these tops\nre rate. The international erature provides an aver\new of itues suchas fatigue, depression, sleep disorder,\nroping [6-11] and social interactions, fay We and\nsexuality [12-15] In a survey among French patient\nround half answered that RA impacted negatively on\nhie fay le andor sexuality [16 In another obser\ntional atkdy in France 80% of patents spontaneously\nported fatigue a the mot dificult sepect to cope with\ndaly Me, whe 15% indicated problems with sexuality\n17)", "te on oe ee ee en\nsense modihing treatments avalable to the Uwealing\nheumatolgi, the focus in clinical practice is move on\ncntel of those objectively measurable disease symp\njos such as disease actly targeted by these Ue\nmens than on the moce subjective and less obvious\nvarts of patients’ well-being. While the relationships", "ihe objectives of the current study were therelore to\nvestigate the impact of RA on patent intnate and\nnual relationships and identify sigaifeant facts such\nis functional handicap, pain and in particular fatigue", "httpe!/ www. beomeccentraLoony'1471-2474/13/1 70", "Gisele Kobelt™ , Brigite Tester-fichesc’, Syivein Wimourn', Anne-Sophie Wiceonom’, Devéd-Romein Bertholon’,\nAleth Perdriger®, Yves Maugars® and Bernard Combe”", "Rheumatoid arthritis and sexuality: A patient\nsurvey in France", "Abstract", "Background" ]

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[ "ch len sean “rscheearch led aceite ile eee learnt. ymlred lar ire\nfluences on mine vertebrates While most theoy and application for OA is based on relatively physical abe\naceanc ecological ystems, ler is row about the elects of accion on nearshore and estuarine stems\nHote, ve Invesigated the tung ofa berthic infaunal commun ina topleal estuarine sytem along 2 seep\nany and pH gacent, arising largely fom ac sulphate groundwater isfows(Sunga rune Estuary, Sores, Jy\n2011. June 2012).", "erp lle scr lana breech abel dca sec cinead an cheba ce call\nmainland in coespondence with the aove-seckment estuarine water ality (ange: 258 ~ 2.2 peu) whereas he\npore-nater pH ange 647-772 was generally lower and less variable tan the estuarine water pH (ange 578-83),\nslog the estuary. Of he thity sx specs (aa) ecded the polychaetes Neanthes sp, Anup oncvega, Nereida\nand the amphipod Corophide sp, were numerically dominant Caled mirocrusaceas (ea, Cyeopaida sp and\nCorophidae ep were abundant aa taone and there wat no lear distinion in dtrtion pattem along the\ntune between clic and nrcalied groups. Species richness increased seaward, though aburdance (esi\ntowed no dnt econ tend. Dversty neces were genetaly postvely ost Spearman rank coreston wth\nlint and pH fp <DD5 and necately wih day ac ergarse mater, exept for everres vas (9 >005) Te faite\nsemblanes were dstrgushed (I) need celpoidsabeld (2) cotophidaptlld and (3) onuphi- ated captell\nThese respectively assorted wth oer slyfpH and a muddy bot lo alty/PH ana sandy bttom, and high\ninte and a sandy botom However, CCA sugges tat specs disrnaon ar cemmunitystuctng & more\nstrongly influenced bry sediment partite characteris than by the chemical properties of the water (pH and salinity).", "supe ren dines cmetaba rabies ihe atrt Ache i aanee eee apache dk\ness expose, ls senstve, and less vulnerable than epberic or pean commis to futher acfcatin of\nsbovesecmént water, These data question the etert to whch al mate fra communes ncing sarc\ncommunities, are likely to be affected by future global CO,-driven acidification.", "Keywords: Community structure, Infauna, Soft-bottorn, Tropical estuary, Salinty, Acidification", "pe 8 268 Om ae eee bacon, we bee bw aoe\nthe more saline areas (6; the sunolf trom the ASS\ncn reduce the pH of adjacent estuaries to a8 low 36 2\n7. Many studies ave demonstrated cat aquatic orga\nzm have trouble surviving i pH levels drop under 8 o\nise above 9 [7], lucating pH may compromise opt\nmally elated Me processes (such as metabolism and\nowt), but also potentially increase the solubliy of\nmln exrbonates and the blowalabllty of metal\n8.10 In the acidic condition toxic metals i the esta\nne sediment can be resuspended in the water columns\nwhich have indirect detrimental impacts on many", "Many tropical and subtropical estuaries experience acie\nfication (ow pH) resulting fom acd sulfate sil (ASS)\nflows [I-5] ASS perturbation occurs when pyrite is\nproduced dung bacterial breakdown of organic mate\nnthe presence of sulfate and ion oaides in sediment\n1], Though the estuarine pH levels yenerally vary trom", "eniien bein hastidionine Redttee\noper eer ees ial Ss\nee", "M Belal Hossain’ and David J Marshall’", "Benthic infaunal community structuring in an\nacidified tropical estuarine system", "Abstract", "Background" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2 ]

[ "RRRRER AED OMEN On tad pete Bend zene oe Ces\nieipts diemacrnatiion Goma dale tenarenard Cheble", "Weight loss {42%} and mucositis (42%) were the mast\nwo common moderate to severe acute toxicities tha\nvas found inthis protocol Severty of mucositis was\nJemonstrated in Figure 2 and 3. Myelosuppression\npecurted subsequently, including leukopenia (39%), ae\nropenia (208), anemia (124) and thrombocytopeni\nGR). Only 8% of patients had moderate to severe", "Rg ARENG LO DenpONiees em Cacia Deias Se PNET\nite and neck nade had achieved an objective respons\nate of 100%. The primary site showed 3 92% complete\nsponse and partial response was 8%. Siaty-four percent\nM neck node sites showed a complete response and 36%", "", "=\na\nas" ]

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[ 5071.033454172313, 19214.19068406918, 13622.207639865112, 1887.4547149550926, 249401.2132301497 ]

[ 1, 1, 1, 1, 5 ]

[ "Bis to hoepitel ave Kiely te sellect « mixture of CA-\nmi CA.tais (153", "‘The oversit high proportion of BEis thet wor\nJeccted <2 days after admission is similar to th\n81% proportion of CA- and HCA-BSI reported by\nLaupland er al for children aged 30 days to <I\nyears in Canada [5] Evidence is lacking on the timing\nof positive samples of BSI by pathogen in relation t\nhospital admission for chikiren in England:\nEnglish, one-conte study reported BSIs in chide\nby pathogen but only distinguished between chide\nwith and without serious underying medical cond\nons rather than CA- of HA-BSI du to a recognition\nofthe changing epidemiology of pathogens causing\nBSIs and the emergence of HCA infections [16].", "needed to develop statistion! models to identity patient\ntnd clinical characteristics such as age, previous\npealthcare contact, invasive procedures and underly\nig chronic conditions that may help to diferent\nCA. HCA and HA-BSI and to guide empirical", "‘The Gate linkage seeults, nlong with our previows\nreview of the puediati literature and other studi\ni adult patents argue thatthe timing of positive\nblood specimens in relation to hospital admission i\ninsufficient on is own to difeentate CA- from\nHCA-BSI in order to inform empirical antibiotic ther\napy [10, 13], Further analysis of these linked data is", "For pappAanantary magierin! acocmepanying thls pape\nvisit http:/idx.doi.org/10.1017/S0950268814003306,", "No external funding was received for this study and 1t\nwas competed within Public Health England’\nHealthcare Associated Infection & Antimicrobial\nResistance departmental resources.", "‘Tha research recelved no specific grant from any\nfunding agency, commercial or not-for-profit sectors.", "Table 1. The proportional distribution by time of 12 pathogen groups of 1386 positive bacterial isolates between\n5 dee before and 3D clays after hospital admission ia chitéren aged 3 months te 5 years, Kuglond", "“The total dct not double coust the Stapylcorcr meus olae teed for methicilin susspiy [msthiiin\ncapil S air (SSA), etin-esstunt Sours (MRSA\n\n| Nampyogeiesteplooelaculer:Abinrophie defect, dercores 0S acidominins, Sacto, S engine\nS bors S msl, dapalactae Spondon group C eeplococin,proupD seeplacoctn, Sintered, 5 ler\nsoup mon S. mis, Sma Sona parcangins oavrie Sanguine S sabrina S abr Sears\nS vides, other Streptecoccur opp.", "Poe Spleen aS ao ae aniS\nNegative chriche col 3 Sh 295) BH II GAD\nSains, 33 TBs t00) He EO)", "SUPPLEMENTARY MATERIAL", "ACKNOWLEDGEMENTS" ]

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[ "rases to upper level trauma sites lor delnitive care. it re-\nains posse that some level IV centers nay have ied\no teat few severe Lures because of tfer ise.\nThese few cues, however, are unllkey to lfluence met\nTeed trond te uendieeae ead eevee hacion", "wolemont 2011) Cound also be influencing changes in €x-\nposure. The nonrincreae in agdeutual injuries ove\nime among individuals 20 yeas old oe younger tay\nartily be attributable to prevention efforts such athe\nNorth American Guidelines for CidrensAgecultur\nTasks (Lee & Matlenga 200), which provide factors fo\nparent to consider in tack ssigament. A sigiteant de\nline inthe number of agrcultal injures among in\nial les than 20 years old was observed between 1995\n0 2006 in another study (Hendeichs &e Hendeicks 2010)\nThe on-deline in youth injury found in the cucent\ndy may be du to a focus on snore severe injuries and\nir eosin of tection accoudiied ap Warman lel FV,", "‘We Kognad a decting in the mrmater of egricwitecel Ia-\nris among females while the trend for male injures\npas shawn a ignfcnt increase, This difrence ini\nry ends by sex could be explained by changes in task\nssigaments. Women may have worked in less danger\nstake eve time while ten may have continued to\ngage in more hazardous tasks. Greater slaty practiced\nby women compared to men (Van den Broucke &", "Table 2 Number of injuries Dy age groups, meachanion and type, and regression estimates", "wip = 12 205/58: al eg N= 1 UNOS OOLENT, Ba M12 (ERODE; Ne N= 6 SOS)\ning auc on spn We man spe es\nned ts cg at rt i ay ad a i ct en", "si Neo Noo Wee) forse\n=\n1-2 Poy sa NF AR 96) 12) 74H) SH 9M) ASK OD aD\nnet 41453) GDH} 47H) HTEEG 124029 WOW! UDINE NOTH neEKE 5172957 anor\nst aug 22m AEM 207) MOH OAM ANIM 31128 SEA) st 44d aD!OE\nvse 07m ep SHS) THLE) ISN 9 HAL HILT HEH UI sIaD 1295 ns\namie Maa RM UAH ACOH 10MM TO] AS) AN aD ABP as\nvatieey 68) THEO EA A09) AAH aaMy a7aA s4UIBH BME es 227 aMHH\na NOt 79H WEE 34) KOE WEED OL WoL HED wR As aD\nromperatone 208M 1612) ED) WEAN IEA waI WMI 28458) 0K\" NM) 235 amos\ninekbyasine RMR] NGEOTO) 1961) AH BM BUI 2H Me — Lm am\nwal RM GEN SOD HAH 9M 2m KR oH» ass soon\nuipecein/ 60 ¢RO OIG HIE OI HOR RMS AH 107 Sem ad aN\nSingin WR MARY NAD HR) HAH HOS 4uH MEH 4a as am\nine\nome 2540) BUNA ERD 57.80) HOH HHH KS UIA TEU) eDIEr VO 701 aM\nnineyy dH ARE ECA) OHO FeO) HOH ALAN SME TINO aw De\nimputers 9115) 22S WER 2104) HEH 2205 WAS] 13H EHO woe OOH\ni\ncpriiond §— 6ft0d SRD GAH AER I6HDH rSGOH WHOA DKA MRD 8 127 aNd\nmenage RMR MR TOMS) 7H) 9M) 744) 1H 1S) sn mer\num MOM OR Gk) 8G] Nee Oe 8B NMG 28 O55 om\nHiccrtovienh MON 6K) 8K) GA BAN 96H 6om@ eR) 280m? ae" ]

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[ 1, 1, 1, 1, 1, 4 ]

[ "properties In previous published studies, we identified 39 MS strain from pediatric patients undergoing ful:\nretin Inv lied tes, id 3 MS om pot at dig\nrow dna ehh, cing al andlor separ of carous lees and pplication", "ee ee", "MS isolates were subjected to arbtrarlyprimed- polymerase chain rection (AP-PCR) for iecifcation o\nsac stuns and irre spitinbion experiment To more recs delinesesin dsb wii", "haiti, with several new emergent strains The majonty ofthe elisical MS strains, as well a the\nwith 2 48-5.$8% xylitol, with vome clinical MS strains being significantly more resistant in vitro.", "rans are dominant at I-year postdental rehabilitation. Most ofthe eical MS strains are sma a yo", "hildhood varies full-mouth dewal rehabiliation thenpy =", "", "eed’ Coie Miuaieraia FMEA Protein” CAEEI Shakeedl al mentee Beetneel Gen cdma\nPorland, OR; ‘Academic DMD Program, OHSU School of Dentistry, Portland, OR: “integrative\nBlosciences, OMSL Schod! of Dent, Porland, OR: “OMSL School of Nursing, Para, OR:\nOregon Cirical and Tanalalonal Research Insite, OHSU, Potand, OR: “Dion of\nBioinformatics and Computetonal Biology. Department of Medial Informatics and Ciical\nBedemology, OHSU School of Meche, Prtand OR, Oral Pathology and Radlogy,\n\nOHSU Scheet of Dentiotry, Portland, OR", "Mutans streptococci genetic strains\nin children with severe early\nchildhood caries: follow-up study at\none-year post-dental rehabilitation\ntherapy", "Elizabeth A. Palmer , Alex Vo\"', Shelby B. Hiles ',\n\nPatricia Peirano\"’, Samyia Chaudhry*\", Amy Trevor’,\n\niraj Kasimi’, Jill Pollard’, Christopher Kyles”, Michael Leo’,\nBeth Wilmot®®, John Engle’, John Peterson’, Tom Maier*”’\nand Curtis A. Machida'**" ]

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[ 14382.91631588072, 8684.593365965178, 15317.255494052428, 16832.939618234057, 13013.595229393686, 5047.190494858543, 1355.9060909450636, 24441.503631298663, 40160.03025564138, 25705.37515088648 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 2, 1 ]

[ "maturation, phagosomes acquire numerous proteins, inchuding\npyraases, proton pup ATP subunits nd endasome fusion pro\nin 16) Changes in the phagosome membrane ands cote\nSp ee nee anty nated dal umaiulie alte toad", "Agee font _sgnery menenemeadiagr as harorhag_semamecdaer\nvith seaomes which cyan asenal endl enyes ad\nstmerblal peptides (10, The aie and highly oxidative env\nment a the phagosome i essental forthe aehation\nathepains, dats a eatin peptides which eventually lea\n pemaien leis ral cleecaetins", "Researchers have employed 2 variety of assays to study phago-\nyoni, nl and confoal microscopy, Now este\nsnaging ow ejtomety and specrlsoremery. However\nchal and practi tatons ae sscated with al of thes\ncliques such a dye quencing, law tue gle ea\npoint readots and often subjective quntiation.ESSEN Bis\nence developed the Incyte 2DOM a plato wich ute\nirony monitor phagacytoss inva time. tn this su\nve report the optinzaion and validation of is lve cel ag\ntorn To quaaly piimary mine and human macroptog\nhagacyenis We show bt ths lato 20 ties moe sens\nive than spectrofuramety and an detect ious fom te\nssimary macrovhage papal-stons.", "ee ee ee eee ee ee eet ene\num, phorbol. I2-mystate13-acetate (PMA). Baflonyei A\nNovas and cytochalasin D were purchased froth Sigma\nsich (Ciinghar, Dare, UK POS was Kom Lonza (Stave\nIk) EDTA was purchased fom VAVR techocoger East instead\nOK} Oph | reduced serum medium, ive Ce nase Sai\nso, PesllaStreptoml, gee piodo\"E ol id sed Sau\nropes\" wet oa ie Techasope (Paley. UN), Stet\ncute\" green plicado” E cl and Zyrosan wete purchase\nfom SSEN Biosience (Wein Caden ‘iy UX). Cytsic\nInterferon (Fy) etedeuia “4 (IL-4) and I-10) were fom\nvoprntech (loadon Uk),", "eee nes were originally fom american Type Culture Collec:\nion The RAW264.7 and THD cellines were a Kind gift om Po\natnon Cad, the BV-2 cl ine war Lindy provided om Pe\npaid Vou Macrophage cll ines tpasage ube were cl\nedi RN 10 medi contig 108 TBS and 1% Pedi\nteponyei at 37 C)St COy Ces ete passaged every the\nys THE cells wore stimulated with SO nel PMA forfour dy\nbefore the phagocytosis assay.", "Retiey sentra: pinnae pir tnererninnriair natin Eine\nspproval rom the Dun School of Pathology toca tba Review\nGuidance on the Operation of Annas, Sent Procedes Ae\n1965) Male §-10 week old CS7BLJ) mice (25-30) were pur\nhased frm Harlan Labratses (Bicester, UK) Alanna were\nposed in 4 12 ghar ye uit wih ee aces oon", "Tee ad Pee ee tented na ce ena a\nibige apd fers om ale CSTE) mice were Mashed wi\npS aod bone marrow cele were v-suspened i Dulbeo Mode\nfed Eagles Medium supplemented with 10 heat-inactivated 8S\n10-15%\" 1925cendivoned mesium (22) apd Te Perlis\nrepomyci Calls were ted fr seen days at 37% C,\nSeseptomyeit. Cells were", "esearch Auton, NHES Commitee South Ceteal ~ Berkshire\nI~ REC 10050571) reprogsamsned wing standardized pot\nsin the nes Mata ter Cel acy st Wl Du ch\n5 Pathlogy, and ther SNP datatets nd ansrigtme ata\nsuse depated in Gene fxpesion Obs (CED) whet\ncession numbers CSE 51425 23) For dus study, MPSCs wer\nhaved and ete a described sn |, Dllecentaiono mac\nhges via emteyold Bal foemation abd ected lento\nsas pracieusie descrteaimaah", "ee ee ee\ntat clear bottom Black waled polystyrene tsue-culte treated\npirplates (Corning, Flats, UK) and allowed to adere\nplod page bioartes were added a hated com\netralions abd the pats were tanslered nto the Inca\nZOOM\" plan wich vias housed isi a el Inaba\n37-58 Cy, unl the end ofthe asa. Two ages pe well fom\na tech seplaes wee taken every TO i for 1 ating\n20% bjetive lens a then analyed ing the neue Basi\noftware ieea channel acgustion tie as 400 ms, wheres\nje channel scquston tine was 800 cn in phate cota el\nentation was achive by applying maskin ode to exch\niste bch Ante ite ns apedto aca\nlow 30 Cen ad re channel ckground aie wae\nraced withthe Top Hat toethod of ckound non-ora\ntection wath a aus of 20 [25] and a thesbol of 2 ee\nded corrected units Muarescece signal Was guaied ap\nng mss (Fig. 1A; mg particles Fig 18; 10 ln bop\nches} Moreover, as seen in 1 the absence othe ees\nol the ste rectgzes the indicate objet at One, where\nrine edge spit sapped, the abet ze recognized a ul\nasl spaced objets Ee splt as theeare sed as or\nA eae nnn ot ieee eet", "ERS (1 = 80\" calls por weelly earn sondied inte TEEN pple\naswell plates (Muni, Gea) in OpUNEM median\nlowed to adhere or? Media were removed ad replaced wit\nther 200 gl plod fed. ures pats st 20\nTC conjugated Zymosa Aor FITC-conjugated ja latex bead\notyscences In, PA USA) dite sn Lie Cll imaging Slaton\nll were ince for nat 37-€ CO llowed by extensive\nwashing Nu\" Live ReadyPobes\"Reageat i ve celia\nlution (Thermarsher Seni, MA. USA) vas added to sl\npce ges were acquied with 160 ebjetive lens using a\nympas 1200 confacl mcrstope (lympas, PA USA) te\ntha temperature controled stage sett 37“ and analy wit\naaa) aofkenre vin", "", "21. Reagents", "", "", "24. fone marrow-derived macrophages ( BMDMs)", "25. Human induced Pluripotent Stem (hiPS) cell-derived macrophages", "2.6. IncuCyte ZOOM” phagocytosis assay", "27. Confocal microscopy" ]

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[ 10331.145844047976, 14308.59717458568, 32581.271926390473, 29561.25724804285, 19297.52694152482, 18516.801481948, 16617.631907944684, 29925.264461977407, 59297.16064408515, 32370.267678691074, 994.4167863236653, 452.7528587712368, 453.7289894991991, 422.60994189142366, 1731.624675240353, 2394.1987862507813, 1484.9955631434568, 854.0831507928087 ]

[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 2, 2, 2, 2 ]

[ "fish eaters (nor the vegans, perhaps because of limited\nnumbers) compared with meat eaters in EPIC Oxford\nHowever, given the much higher fates of PSA testing\nin the Adventist Health Study2 (733% ws 31.5% in\nEPuCiCheliredl. abtensien Scans peraucine exe Baie oo", "be ciirent in. fhe tro popelntions, and therefore tae\nresus might not be direcdy comparable. Sila 10 our\nStudy, the Adventist Healt Study? also eeposted lower\ner use of HRT (adjusted forage and race) i peseones-\nstarians (21.0%) and lactovegetariane (204%), and the", "Table 5 Medication use for specific conditions by diet group of participants in the EPIC-Oxford study\"", "ondon an the eed (1D-ea follnap uesonnare\n\ntm reparing te coetan fran ets ce oped gross and rumbet (taking sopoprate mascaon were ae bsare\nrevlence mins eestor te won dase of ot sage ln apt, ant, tS 90-54 5-58, Soe, O58\non, yea) region lesen (og eps slteprted cert eat cele goo a, poe unin yer sce repre\neg bland you of town queso caieton ee pats yuo Gagoaes 28, ra 8 oD pone ow.\nra naber fat pasted passe or andi? 3\".\n\npared wef! stone famed eral urere, propre, stra endo, hop and nein\n\nparted ne fast one strana ndsmariin\n\nepred uefa sat one of becemethasne an ssa\n\nyrPosted use of at leeat one", "Penticipaste reperting the Pesticipente taking\n‘ondtion,n mean years since appropiate\nCondiion/det group ___reported agnosis medication, n(Csht Prevalence ratio 9S: Ciht\nHigh bid pressuet\nMaat eaters 497 05) 2572 (8.5) +0008\nFen eaters 68603) 3871620) 0.97 (088 01.08)\nVogetarans 9ua@0) 420 486) 091 @.82t0 1.01)\nVegans seo) ours) 0.92 (087 0 128)\nP netorogenaty=0.57\nHigh bod cholesterl§\nMaat esters 3351 63) 1646 42.9) +00 08\nFen eater 58163) 209,073) (0.88 (07610 101)\nVogetarans 645.65) 24a @77) 0.94 (08 to 1.08)\nVegans “on 14,818) 074,040 128)\nP neterogenaty=0.20,\n‘Asha\nMeat esters 1385 25.3) 737 08.) ‘00 08\nFen eaters 496 902) 1604.1) (0.98 (082%0 1.17)\nVogetarans 758 23) 246 @2.5) 097 (88% 114)\nVegans aera) 17193) 0.87 (041 10 1.09)\nP reterogenaty=0.45,\nDiabetes\nMaat esters 707 100) 446 62.9) +00 8\nFen eaters 751148) 41647) 0.78 (058 01.08)\nVogetarans 119108) 4705) 1.05 (28 to 1.35)\nVegans 7032) 657) 1.07 045%0251)\nP neterogenaty=0.48,\nThy scasett\nMeat esters 1505 132) 1191 07.9) ‘0008\nFen eaters 880 118) 23018) 0.95 (083 01.09)\nVogetarans 485 (112) 337 (25) (097 (08540 1.10)\nVegans ss (118) 37 66.1) (0.88 (0.83 0 122)\nP heterogeneity=0.78" ]

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[ 14973.812200000044, 14942.673339999747, 4389.981596269754, 40756.56029439997, 242193.30407800002 ]

[ 1, 1, 1, 1, 4 ]

[ "The cocestelk between TWIGTT sad Intermediories of eiiesat coll signaling pati\nways as previously ben demonstete. thas been reported that TWIST has ani\nverse cortlation with SNAIL in ESCC KYSESO cells with the suggestion that enforced\nexpression of TWISTS may negatively regulate SNAIL expeesion [16]. Furthermore, 3\nnew connection between TWISTI and the teseule cancer antigen MAGEAA was te\ncently reported for KYSE3D eal. The performed functional study on ESC calls\nowed an elevated level of MAGEA@ expression aller TWIST! ectopic expression, and\nconfiemed indiect binding of TWIST! tothe MAGEAS promoter eon lading tin\ncron enrmeosinn ot MEAGEAS ot bow Yan mich aud joniein inesis [ETL", "eh ena Be gRCRS, Comeeceoes, etree 2 verse AL AA: Xe ce ee\nripion factor of Uke Notch signaling pathway, was reported for ESOC patient\nrough advanced stages of the disease, suggesting new crostalk berween thes\nsiciees Se GCC ees eal eaatastenis EL", "ore eens tie Breet patente Oe 2 ee te eee reer\nof a wide spectrum of genes involved in vatous cell signaling pathways. In line wit\nhs statement, dhe impact of TWISTS ectopic expression on OCT# gene expression\nwas revealed in this study. The OCT upstream region consists ofa proximal promote\ncated ear the tanscription stat ste and a umber of distal enhances. As showa i\nFig 2, there are seven diferent E-bores inthe OCT# promoter region. TWIST may\npind ether dieetly oF indectly to Use sequences and teanserptonally upeegult\nOCT gene expression. Confirming this cortlation, our in sco analysis introduced\nETS2 protein as an important linkage between TWIST1 and OCT¢. As depicted in", "COE 2 BAS NURSE SRO HORMONE OF ECR TIRUCRCCED CONSENEUE SACHANNCR (CARTERS In\nocr umsciggon unt", "", "i a\ndoraet73-7410155-0 4, 10485-10704 96-420 43-438\n‘Sousa\n\nmci ayaa veasiesnnasainao ras\n‘oa 28 See 985 10895- 10584) 10640\n\n- ‘54am. 6-052 12388-1226412518° 1252813805\n\nSawiisoa 1a a\n\nware 8 2am aaa 10" ]

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[ 43805.52686198242, 16719.980419747764, 44564.51303797588, 4401.502541922586, 858.4977340189216, 103108.72288259203 ]

[ 1, 1, 1, 1, 1, 4 ]

[ "relating fo His elects on Gr Dealt, the eliect of Fax\nonsumption on oral health parameters has sessed\niediel atieatien C1 3.", "We ae ee ee ee\nJependeat nature ofthis probiotic bacterium ia 2p\nf compete denture wearers following 4-week perio\nof Yakult consumption. LeS was detected by cule i\natv ad ia tongue and deatre biol upto 7 week\nom easing consumption, but here was ao ideation o\nsermanent colonization (20).", "ee ed\nYakult containing LeS on oral microbiota ia eal\nvidal ith fall dettion was evaluated. For the Gt\nim the efet of Yakult consumption onthe levels o\nVSCs preseat in morning breath Was vestigated. Th\napablity of LeS to colonize oral surfaces and pers\nJung and postconsumption ia salva and. tongu\nofl was also investigated using slctive culturing\nsad saslendes Uieniincgtunn eaedrade,", "poved well or differential Kolation and quantification\npresumptive LS fom saliva and tongue plague Fit\nive poco of tested salivary and toague plague oat\nwore postive for tbe presence of LeS specific antigen\nJtected with ELISA, ad marked 299% sna o\namplified sequences to L parece! and L.parcase\nubsposesparacae.The probit stein Le belongs to\nespecies pratt sccoudng to recent recacsifen\njon (38, Utilzation of LeS Selet medium revealed\npesnce of LeS in saliva and colonization ofthe dors\ngion of the tongue (upto 10\" CFU per mite o\nalia and per square ceatineue of tongue surface\nJung Yaklt consumption. During the washout pid,\nounts decreased to pe-eatment level indicating thal\nhis trai didnot colonize the oral suiTaespermanetl\nThese findings are ia agreement with the esl of ou\nvious ivestigationl study involving complete denture\nwearers, where LeS was detced ia saliva, in dors\nongue plaque, and on denture saface during and post\ntecmeation, int Se us iecisod ems cay CX.", "speculate sat the resident microbiota ip chitrea st\nmature and thus easier to medily 39. The evidenc\nom intestinal studies also confi transient and\nonsumption-dependent character of LS (13)- Iso\nhat Scan be detected faseal samples for only inte\nseriod after the end of probiotic ingestion (29),", "eee\nsterventon has received some atteaton (10, 35-38)\nColonization i thought to be teguted in onde to ats\nhe composition oestblsed fn, suchas subginga\nof tongue plague. The authors (10, 38-38) found that\nobits were only trasietly present in orl sup\nunl slr during the consumption period und shor\ner discontinuation ofthe eaten, eventually con\nng undetectable In terms of permanent colonization o\nhe oral eaiy there is only one case of sable and long\ncemestablshnent of pobiots described by V-Kauutt\nal. BT, i which an individual received Lactbcl\nammasus stain GG. probiotic therapy at the age o\n(Oyeursand became permanent colonized, The chat\ncs of Gis checeeeaee ie ein: hee pec", "ae ene een TLenOes Ab Cos®, lrequency fone to a\nouple ines po da}, or dation of probit consump\nSon (inl # couple of weeks} described i in io Wal\nno permanent colonization of oral surfers has bee\neorted. Authors have alo investigated a variety ol\nJlivery vebiles such as Hiquid (mil, yoghurt, jue, 0\nmoutvash), sold cheese, lozenge, abet, or capsule)\nind various other dvies (chewing gum, teas contain\nng probiotic, or pacemakers) ih onder to investiga\nwhether increased contact time with oral surfaces i\nroves colonization. Consequnils it hs been propose\ntat, repulse of the vehicle, in the presence of the\ndigenous microbiota found i adults epeated applic\njon of dietary probiotics i necessary t maintain the\nJsred probiotic eect tis possible that the alead\ntabled microbial ecology prevents introduced po\ntice from colonization and becoming 4 part of the\nsen pnwheal bhatilee", "ee Se eee ae\nesnce of Le alate existing microbial populations in\nhe mouth. Consumption of LS didnot appear to hav\nany effect on naturally cccuring orl candida found i\n3% of participants eegardless of whether it was a om\nant of temporary eumige of the yeast Consumption\nlependet colonization of LeS hd no sgnicaat effet\nothe viable count of salivary or tongue plague candid\nouahout the studs. Acording to ou ero iad\nion studies (uapublshed data, asther LeS aor Yakul\nxerted antifungal proper on monoculture of 1s\nins of Candide of clinical candida isolates (C\n\naWicans, C. krusel C. tropicalis, and C. guilliermondi,", "eee\nound inthe moming breath is generally recognized as\nurtogste method for evalting the electvenes ol\nrarous haiti treatments (40) With the exception o\nome individual eases, there was no ovr signiean\nfet on momning breath measured with the Halinets\nand OralChioma during the Yakult phase. This may b\nue tothe lage variation between sepeated readings i\nhe maj of subjeets While the present stay wa\natid ut with limited number of individuals, ti\nworth acting tht a plot study performed in ou labo\nory, which involved 19 bealthy partipants and\nhe same Yakull-diaking segs, showed very smi\nHalimcer resus fo this ial which stengtbeas the out\nsome of the current investigation (reculte not presented)", "an Bis study, & portable gas chromatograph Ora\nChroma (23) was used to measute individual conceatr\nions of the three gases in morning mouth ait. In ous" ]

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[ 1, 1, 1, 1, 1, 1, 1, 1, 1, 1 ]

[ "reas? A) signilicant'y correlate with longer follow-up\nof patents, Our results suggest that on average, the\npesence of protective allele atthe helerozygous stats\nwould crete patent fllow-up by SI months wl\nhomozygous atus would increawe this index by\n77 months. Ths, these SNPs could be used a8 prognos\nie Homarkers for length of fllowsup following radio\nherpy, a8 patents huboring protective alles. hae\npigher probably to lve longer (Figure 2)- Estimated\nmedian fllow-up suggest that harboring one protective\nlle ofeach ofthese SNPs would inresse survival by\nbout 4 years, while having the 2nd protective all\nseid nat 2 seca woe", "Sennen int Kagrermen, Maat neseeees Oe komt\ncet of vatious Hk factors, has conte the assocation\npetween HDM2 TIG ws2279744, HDA T/A es 196233,\nTGFBI CIT est800469, XRCCI GIA 125487, follow-up\nand radlosenstvty (Table 2). These are intresting resus\nhat plaid in favor ofthe potent use of genetic marker\n4s predictors af normal sue esponse and prognestco\nfllowup. This is an important concusion since the\nsubjects curently aot top debate [7] Far instance,\nargs pompective study hat fled to replicate previously\neported ssociations between indvidual SNP” genotype\nsnd radiation toi [7]. On the contrary, genome-wide\nscmichdines Gly sudaation eucmie apduaction", "re) eee reece Ot eee Serene Pe ee eee See eee eee eee ae el eee\nminional {contookes @D-2) of aavere (casas: 43-2) late reactions (Misreals) after endiotherapy", "asia 1 vectentny as udtd-tnre aeee \" Adele >: ano\nAbela 1: majority or wild-type alike.” Adele 2: winatty or varand allake. Nt Nes tsformasive because cf low frequency.", "" ]

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[ 34620.24675985379, 36131.96325622685, 8932.096168199976, 4146.061646128655, 202394.85374096181 ]

[ 1, 1, 1, 1, 4 ]

[ "Clinical and Wboratary characteristics of the enrolled patients are\nom in Table | in which piers are segregated according tet\nluna ae els No flees were ered between he te\npasa in, except fo CPR (p= Ot) an lod leat (p=\nNON) af wich eels ere ger ate upp ees We made\nia anal comping soups ol nds septate scr\neres of iy take sine No gicant derence was ound\nweaned tha graces tn any of tha teetad varishlas (net shown)", "TE nen oe eee ne ee\njune, both plasma CRP ad ie level wee grouped into ets\nce, mdthaale odin egit cagresion nae wee pre\noases the lain beeen CRD series ars deren ete\nama ae whe wing the est CD ere she eletence group\nthe wasted model (Model!) apd aller egsessive adn\nforge geet. hypersaline, ba\npercentage an se of stats (adele 4) he ihe ee\nnc presented ie ssecton with igher CRP (Fe) The ae\nody iste oan stash CR eels (p02)\nwith kaye (p= 8) We repented the mulivarible odia\ngai repenon nde to ses he lation been CR caer\nos dierent elo da tate a ne There aso Siac\ncin td abd ole sein een", "Alpe Cheumn tn Table 2, Mare wee ne sguticont dilhernce\nMD, ma of nia ert MT, een BT 21. CAC\nsence of crea plague, remodeled corona plague lo\ntenuation nnckied coronary plague between snc ete Uke\nvc thee wasn sigan dlerenc betwen the groupe in cao\nel complane sis inde ot Young’ modulus eve et\njsting forage gender, yperteiondabets, goer aio\ntan ue fins Tale 1) These ngs ened a Sat\nys when we ected sls based on he pst\nin else oy ei ae feat ana", "ad arterecioric iseaca has boon tased desea sconcistont asso\nao wih jemi alamantary marke. Te presen stad es\nns asumpion nthe very elderly, bch ss popaltion expel\noe taste nuritonal decency, screed intr\nty ad ati wal dees Aabough we ound igi as\non ween ste arnt acta plas i ve\nae wn ta a ln bene pl a prope", "pou also have endo hen Cysrunctsan and increased arterial walls.\npes and aero, However, nour coor, pasa i\nvelo dl nate of ne was at asocted with emda\nuncon bod presse, ate wal stifles or aera bu\nse in eta coronary ater a mechanistic posto ie\ncommie hove inamenatry ae lets he aspera\nyin sever aes The ft ean change ne dsb in pl\nmand sues wba alec the tll sn sto By irene\nly hatin individuals with ly levated 5st inflaton\ntv. such hat nde by aerosols\nte pase flammatory respoase Ths ssumpion must Be cn\nand epee Aan", "ent ofc astoated with increased serena iflanatn\nloins 15} Axhough cella ana past concentrations of\nrao copra avers rua betwoon pasta tn\ntreaty acti has ss ben feported and wis conned\ni dy Acorn these iatatodty oer a neo\nadi empect Gaad Sedtuhieehi passin eaten d olancoe sine Seek", "SN Se ee ee ee\nnd crower disease was sil eporteds younger ads\n17.18] a the prespective Pisin Heat Stay 9\naii aged SO yeas ae that were andere to at\nonal supieeotaan withthe daly recommended dose a\n11 mglay) 0 plcbo ding 12 yes Ts cur een cigs\nerp To previo eens td suggest tithe e asc\nion sexended tthe ver ede This ay be putty concen\nsei hat Aeris spend wand $2 bo ea an mt\nannie sppemet20) andy the ageot 71 yet ler, 38\nretain espn [21] Sa evidence eis sepa\nTee eae dene", "_The association lerween systemic immnmation and passa zinc\nwha hd upto ve ane te econimended etary alwace ef se\n22 ndeating ak ht i regan intake. Consent\npatents wath umn a see acy beter pedi\npls ine than dary actors [23 nhs context, we ured tat\nhe ai between the las vals and itary ike of ie was\navery create with CRP pasa levels suggesting tna\n\noption ab stem iflanination ae Unk Inded nese\n\nanmatry ait was previ fod toe peice fede\nin raster acti in india ith ype 2 diabetes melts\nDejandeteay (zs)", "Reridenthe steel of taiemmnetiome niac oenepareers nat, Oy comes\nenc, abserpton fom dit, plsna zinc concentration al\nate tos Gatchuton eeween exces fd yl so sues\nan anal tel was shown tthe Wer expres of\nransporters i pegulted by itl [25] Cancels\ntein ss Stns RD sats by the We\nnance production of hs kine, bse aged inal\nay satanecnsly under bth the production of CRP and the i\nrene ohepat pak oli Tha ahh in ea nd\ndtr ea elated tbh store a pas conn\nio (7th soction deco due othe nce ofan\nSaeed meee eadden tn,", "ee ee eS eee\neset ndings The fs al mes portato ses\npronrnad vaby of car facings. Wie abeead ws taustigane cadicnecsfer", "", "MEE I EE Ce\n SmPeniaa i: Maat Aupetneied teres ecmutec teeanemien onteinn anauemae tarde ape uel eaesteme", "", "", "" ]

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[ "PRICE OF EIR Yeates EEA Figen: Thee 2\nrapmentation pltem perfectly matched t the nce\nscue tt EO,", "Setermined inona the Micheelis-Menten plet fee Kinetic\nanalyses (Figure 3B). Reconsttuted HgD catalyzed\ning cleavage in a substrate apeciic manner with only\nHQ as the feacon substrate. Neither substitute\npydroquinones (eg. Chlorohydeoquinone) or othe\npphenole compounds (eg, catechol, resorcinol\n‘Morocatechol and nittocatechal) were used as the\naction substate by this enzyme (ata not shown).\nim presence af ferrous ton cheator eg 2.2-dipeidyl\nhe actly of HqD from stain S)98 was completly\nbalished.' The inactivation of enzyme. activity\nsppeared lreversible since it could nat be zestored by\ntended incubation at lower temperatire. with o\nwithout Fe(ID. Rapid and complete inactivation of\nconstituted HgD also occurred upon incubation\nwith 100 4M hydrogen peroxide. Incubation at 40°C\nfor 30 tin and ASC for 15 min also resulted in\nmuvinis tnnchoaiten of tae Teal anthony", "vatal'ytic properties of Fig) were routinely analyzed with\npectophotometsc assay that monitors ring cleavage\nising HQ as reaction substrate and realing in forms\nson of 4~HMS (as descbed above. HgD actly was\nserved only in presence af Fell) and maximum act\nty was measured at 100 uM FeSO, HgD fom stain\n}98 shows a broad pH optima ranging fom pHi 7.0 ~\n3.0 with maximum actly at pH 72 (Figure 3). Opt\nmal temperature for HgD actly was abserved in 3\nange of 25 ~ 30°C [Figure 360). Kinele analyse\nowed a Vinay of 985204152 ymole min yg and\nKm of 653241049 pM (at pH 7.0 and 25°C) 2", "ee ee tee eet\ninehed upemtr of rp ad pp ane 2 Indes hl ce ate of ppl and pg Lane 3 Soper fp] ae\nrs pot rete pn ae pred an pret el rd pe ec Seon\nneriogsy of abut ot yemunane Sone ing phe Gl Reon re eed a rom he kan\nmand be 3 mona a en Pe aged anand be onar 29 10 a Mie fat\nccna cst pony sd newt he pss dane eae ae", "A mM 1203 4 5 6 7 8\nswoon gg\na0 Ss oe\now. Ss se\ntom B= Se\n25 gs .\naa\nB\nf fw far\n4 i z l\\\nA . }\\\n7 oe a leasnanssad) euscee)", "catalytic properties, suljstrate spectiscity anc’ stabuliy 01\nep) from semin S10" ]

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[ 1, 1, 1, 1, 5, 2 ]

[ "Apt PRR 2s Se eter Oe Oe Pee Ot arenes\n3 displayed. From Figure 3, can be seen thatthe pee\nvalence of pais of diseases increases with age ad tha\nhe pair of greatest prevalence for most ages dlabetes\nn combination with AMM, and the pai of smallest pre\nlease te CVA ta eumbiaeihen witremaees", "soon that for disenes combinations wlhent cancer,\nsbserved minus expected co-occurrence of disease pls\nereates with age. For combinations of dieses includ\nng cancer, observed minus expected co-occurrence\nnegative in an age range cough frm 60 to 75 or 80\nyears, The abwolute degree of “unexpected” co-oveur\naoe bs Mahaet fox es eomdaeaion Onshates tod AAA", "Figure 4 displays observed minus expected joint dis-\ncase prevalence, indicating to what extent diseases co\npceur more often than ls to be expected under the\nrssumption of independence. From Figure 4 it ean be", "Te appraciete the wacertelnty eucrounding this out-\ncome measure, Figure 5 displays confidence interval\ncround observed minus expected co-occurrence for all", "ee\nsroportions observed In a particular year tn the POLS suxvey).", "53] os] 2] = °\n\nis en is Cd 4\n\n8 weit |g scr\n—s ——s\n\ni i\n\naan > | E28,\n\nBS Bas| ts sagt\n\n#2 eS] GE tee\n\ntg 3, te Z\n\n: fel, 7\n—s —\n\ni i\n\nols Seiko” . °) = Skier”\n\nB eG Be] 2\n\nbe ges) oo\n\npe sens] Ee aoe\n\nrs a es | eS ,.,\n\na moore |g ‘\nee ees" ]

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[ 1, 1, 1, 1, 1, 5 ]

[ "INTRODUCTION", "METHODS", "RESULTS", "DISCUSSION", "Qualines Delp smokers tn stop but ew\nsie ave exloed bow behavioral nd\nmedical errno can be opi\nLee via the route! One of ee na\nthe PORTSSS eri wick found tha fer\ngree nicotine replacement they\nINR) vouchers dil noe ncese coon\nmics compared wih no ier alo\nound tats \"proatine”, mote intensive el\npie foc cents dil at prone ce\nom atrovent car’ Wa pole\ntar pariante who did not race 3\nrocker for NRT sought out and wed\nmer forms of cenation spor, which\nminnie any elec of receiving the NET\nrucher) Use of noma suppoe varied\nrom PORTSSS eral terete\nsui this analy te sgh to deter\nmine weer or ot se of ths sea\ncally affected tial Gacinge.", "eee\nsing a parllroup, coral 22\ndesign. Noni suppor wed by pati\npar inloded “one the couaer™ NRT\n(2-498; 19.29), NIT fom hea profes\ntonal (795, 18S%9), bupropion 7\n140), waren (165; 68), NHS op\ncoking serie mipor (125; 4.890, NHS\nones. derapy (21; 4.5%) and a\nnom NHS gine (0; 1.599) any spor\nO78, 37%). Binary” vara wen\ncae for each suport spe with ep\nct coded and moet We\nmed the same meltvarabke ppeson\nmodel 3 nthe orga ial ana wh\nhe ef of tresmene soup aed Fo\nss gender, ag: of Snshing edaton and\nbemines fk nd he analy\nsated for each of te bay intro\nse of oer spor 0 te hee\nss dhensd hadnt arimeanee,", "Se ye eee ee apreee\ndomed participant ofthe PORTSSS\na PORTS. ws tandemicd con\nrolled eal (RCT) of an Enlsh\nsverment funded gun, compara\nSe tenis cr usinciecel abate alae", "ae\nfable 1) show ile erence the al\nEodinge wh sepect to the primary\ncco, prolonged cen a on\n(il model OR 086, 95% C17 vo 106\nstonal model OR 0.84, 9585 Cl .66 2\n1.07) or any af the secondary outcome\nirepectne of whether selfropred\nvalidated smoking ounonmes are ceed.", "Se er ee ee\nhe negative POKTSSS trl ndings et\nopt NRL We identi ony on\nher paper mesic\nprmeen ineotces abe of he\norm of pp found tae smoker\nwho had ened tbe types of como\npar peor to gavin eae me\nore Ly to ssesely op aman\nvith tine help. ale kaon south\nls conten of guns sd om\njtline apport so smoking ceo: om\nring and ealsing the elon\nowt eeston ppt to cme\nfamure quéline audies important.", "Key messages", "0 cour Knanwiedee, Os is the inst analysis to\nvege the ele of aden com\nsuppor othe pone of ree NT prove\nWi from a quidine. The findings squea", "relation to nicotine replacement therapy (NRT)\nTable 1 Smoking cessation outcomes in relatic ppli", "cle Teac Comal dee Urheaa gd\ncee reba Cora sas, Uy\nrg hea\n\ncn enh bt one\naoe Sa ey", "The PORTSSS tsied Femme thest ciering\n‘re NAT voucher to tine ents\nid not improve cessation rates.\n\n» Use of ote eto ipa ed\n‘vee the al dno empl he\nnegate PORTSSS tia naings with\nresect to NRT.", "Does use of ‘non-trial’\ncessation support help explain\nthe lack of effect from\noffering NRT to quitline\ncallers in a RCT?", "Aadhy Ohcfnan Linke Bould? Ten\nAndy Mcfuren.” Unde Bauld? Tom Coleman!", "MikWpeonoiimtalu~n\ntAdkStionully adjeste forall forms af tow trial support.", "SO ee Se ee A\nNinior_Wetase Atos ateepeae)oncrpuon) fpr)\n\nans mae\n\nTalngedente Inc ueonin si 0185) 21 9ON) 8 OAS NIOWIOG emARKI owt mss\n\n(eon re pan pa ram\n\nCeormeniealisdeelendacon 201A 2B KH CwTMSMOM, EBReRoe San wOe\neau pa rome\n\nSega aon 2 ap S105) mn p1a) amps) Easmmw ro, SusleMeIe; emer era\npass pa ram\n\nCromemitaliadcemtntersrae 2007 1982) m2) a MNOM EMT eON da NA HOHE\npeacit peed rome\n\nepee aston 2 oss) 76066) WN BHMEe LO, Loser OAs\npass pale ran\n\nepsom me git men eg 24ht S25) 29023) msm) waa Tamer TS MaN tse\nrs pe ra\n\na J 98. gustan pet any 202 = os\n\nbaa ann 8\n\nTelnet oe i st i040) G01) 2040) ONS MAS IIE Lo EeLI Lame\npass pase post\n\npea catn 27 img me mma ane Ewawer oNM eae\noa = na" ]

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[ 2, 2, 2, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 3, 2, 1, 1, 4 ]

[ "a ere ae en eS eee\nmortality and morbidity of patents a ceitial condition.\nThere is debate over whether ealy tracheostomy within\ndays, shouldbe or nat performed during the sty inthe\ntensive eae wit and it eatonaip with improverent\nmortality and morbidity at discharge and 28 days\nRecall contlled clink tal to determin that\nhere no difference between eal o ate wacheoston\nHowever a subsequent meta-analysis determined tha\nFthece 1s improvement in the realization of atl\nceases", "Deteeming if there be association between the spallantion\nearly teacheostomy in the meta and complications\nof adult patients in the intensive care uait at discharge\nii 38 a.", "Historical cohort study of siek andl association. Data weap\nroapectvely collected for consecutive adult pation\nsdmitted to Agustin O°Horan Hospital ICU Mesa\nMexico, between January 2011 ad Jl 2014, who under\nvent inpatient medical treatment using electronic files.", "racheostomy. OF the 595 patients collected, patients\nwith early acheostomy after admission (a= 419,\n19.2%), and late tracheostomy (a=434, 50%) were\nmatched in two groups. These two groups were well\npalanced with respect to al varables collected, The eat\nracheostomy group had at decreased sk of mortal 3\nCU discharge, rele rk rato 078; 95% Cl (078-97\nwith 4 decreased isk of 22% vs the late tracheostomy\njroup who had increase rik of death at ICU discharge,\nlave rk rato: 115; 95% CI (105-117), No sigan\nferences in mortality were found at 28 days and no\nferences i complication, Earl tracheostomy was a0\nated with decreased mortality whitout additonal comm\nslicationa; this association was statietically important.", "Rie: arenes Compete Ge aru iethcm geen ea een ee\nible. Early tracheostomy was quite common, with an\nneidence of 49.2%, Patents were propensity matched\nbased Gu Cache ameclation With deel on carte", "Figure 1 Mortality at ICU Discharge.", "sul:", "introduction", "Objectives", "Methods", "", "Association of early tracheostomy with the\nmortality and complications of adult patients in\nintensive care unit", "MF Aquilar Arzapalo’ , VL Avendafio*, AM Escalante*, J Gongora Mukul*, MA Cetina Camara’," ]

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[ "a Oe rates OY Single age: Obsesvee in the carencr yours Vso in 200 ane iorecasee wn our\nexe model nthe yeas 20200 fr waren he UK Ql ac Orato Te tanto\nre", "aaa" ]

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[ 9298.243689858937, 170500.5751375754 ]

[ 1, 5 ]

[ "music therapy [55] and’ sensory ivision, Nearing. sme\nuch and taste) intervention (3638), and care when\nsecsian fas end of Rie", "articipants with dementia and’ carers were clear they\nwanted to be, and remain in 4 famllar envionment,\nwith their awn belongings and familar things. Pract\nomer, howevet, ed the dea of «dying rant to which\nhey could move a person who & dying and in which\nhey could create an atmosphere of calm. Pracitloner\nso liked the ies of dying box frm which they could\nlect items to creat calming, homely space. Thee\nsupport for the benef elects of providing a calm en\nronment in dhe Iteratre an the Narmste approach to\nhe cate of people with advanced dementia. lvolvement\na Namaste Care hat been shown to improve interest i\nhe envconment and for cesdents who are withdrawn\nor have reduced social interaction: patelpating in the\nprogram decreased some indicators of delim, and de\ncreased the need fr administration af ant-aniey ed\ncations (39). While this research focussed on peopl\nwith advanced dementia they were aot at the stage\nwhere transfer toa dying room would be considered\nHowever itis not unressonabe to extrapolate the bene\nsofa eal environment, without necessary a tans\nion igen eh ome,", "Peaticipents with Gementin aad Gully corey were\ndear they waned cae and an envgonment that ensured\nlignity and pelvacy. Most of them were slo clear ofthe\nned to ensure this increses with increasing copntv\nmpaement and this particulely related to having ex\nsre to ensuite bathrooms. Practitioners were, ca\nrerned about the bulance between privacy and aie ~\npossibly reflection of a focus on desig to enable fl\nment of duty of care as opposed to failing a “good\nrnd. All participants recognised the need for fly\nmembers to have aces a qt, priate spc to es\noni wis ieee", "Of \"endl of Mie’, with 9 Secns on the actual event of death\n40). A recent review of the Ieature found sulipl\nstudies abserving higher usage of restraint, sedation and\nube feeding among people the final stages of dementia\nhan in other trial netes or those whe were dying\nwithout dementia (26). Ths esearch and the responses\npovided inthis study, suggest that cere tle aware\npss of the benefits ofa reationship-bused care model\nwith iis focus on leadership, teamwork, professional\npursing practice, patent care delivery system, resource\nriven practice and outcome ineaurement with the po\nsent ad fay at the centre of all activites [41], Ther\nneed for increased research, education and approtches\nend of if car for those providing care to people ving\nresidential eae, especally chose with dementia nearing\nfee cod ot sk ieee tae", "Rive EHS 8 EE Pemcunnniere ave Oe [ere\ncrn as they difer 50 much fom what we would like to\nink ts nora, good practice. However they may be a\nstark reminder of ral. They recognised thelr practic\nvas constrained by organisational and institutional fc\nos, ach a8 funding arangements for delivering care,\nesurce and safing levels and inadequate design of\nate stings, They ako appeared to be unconsciously\nconstrained by unquestioned practices, such as institu\nng syringe driver on recognition that someone\ning and the practice af bling pallets according to\nheir needs of levels of impairment. These seemed 0\nquence thle perceptions on the Importance or aterwis\nof aspects of the enviconment for people with dementia\nparing the end of ie. A study of Gl care managers’ per\ncplons and practices toward end of fe care in as\nst Li con homes eee 4 ees Gt eeepc", "Sees eeesente dl ee Ce ey Oe eee enrres ae\nved from the Meature review ad expanded on by the\nacu groups, the panel of experts showed a high degre\nof green on a et ofdesiable features and were able\nent, and agree on, a set of additional features,\nThus, the environment should.", "The qlements of these design Seetunes ony eymucnactped\na Fig 2 These can be understand as environmental\nurements for mesing the paychosocl needs of peopl\nwth dementia while they recive care atthe end of thee\nses, and support findings by Godwin and Water who\need the wishes of 12 people with advanced dementia\non what constitutes a helpful environment for end of life", "5 Support the coneinued’ use of the senses\n2 Provide access to the outdorsinatual environment\n3 Provide acces to nature indoors (eg, plants natal\nlight, sh a)\n\n4. Provide opportunities or engagement with spel\naspects fie\n\n5. Provide opportunites for social engagernent\n\n6 Promotes sense of faniaity and homens\n\n7, Provide opportunities to be wih my\n\n8 Promote calmness\n\n9. Provide petvacy\n\n10, Foster digi\n\nI. Suppor safety and security\n\n12 Suppot staf. residents and vistors to Bnd thee way\n\naround/Knaw where things are\n\n12 Enable vel monoring by staf ~via human\n\n‘contact and not through the peton being placed ia\n2 public area\n4, Reduce physcal stress (eg provision of appropiate\nIedsimateesss, managing odours and temperature)\n5, Faclitate nursing cae (eq flat bathing. eding\ngoing to the tale, moving and handling sist\nptr harhephorpnioarenr ing" ]

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[ 1, 1, 1, 1, 1, 1, 1, 3 ]

[ "ee ee pee ees\nhove questio, which were reducing reliability.\nhove questions.", "OS eee\npeacties and behavouts (questions 12-18) To facta\ncompletion and scoring, the numberof posible response\nper question was limited to Ue (a, bc}: with answers is\nhea eatezory deemed appropriate ordesable coe o\nbles thaw ideal (core of 1), and °° ndiatng\npotential eause for concernlacion Score of) Allitemsi\nhe qustionnaie were scored equal given the absence o\nata regarding the rlativecontibution to dietary riko\nferent items. The maximum total score obtainable wa\n22 from 11 questions ia Sections I and 2 Details of th\nNateicheQ questionnace as administered is shown i\nTle Prior ovation, principal component anal\nPCA) was used to identy underlying components the\nqustionnaite, whereas Cronbach's alpha Was used as\nvat of teliability (Stage 3) (30). The ‘Cronbach's alpha if", "NutriCne was administered to participants of hens\nNPNS fvaldation study, Suge 3) conduct by Uni\nerly College Dublis (UCD) and Univesity Colles\nCork (UCC) as pst of the lish Universes Nuttin\nAlliance (www net). NutricheQ scores were the\nompared with relevant fod, nutint, and aathropo\npeti and ifs parameters collected inthe NPNS by\nained researchers as outined below. Ethical approval\nvas obtained from the Clinical and the Human Ethic\nResaich Committee of UCC and UCD, respectively,\nund informed consent was obtained in accordance with\nfe Hisicite! charade", "Pee a. Giverview ot the development and valkialion process ol Nulrichetl)", "I\n=", "Valoation study", "study Gesgn" ]

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[ "An sesccistion Hesamer De acenicepy apace, & Ciavene cf te wiille matter of the been, enc! senckingy heecin ie\nwel recognized, This paper describes 27 cass cf leuloencephalopathy identified in two cies in Bish Columbia,\nCanada 2001-2006; the largest number of geographically and temporally defined reported cases in North America", "ESSAY ates ia geen ees cena eels eee) TH AN ees Shel ee ec\n© uly 203; sever Further cases were dented in Vitora September 2005 August 206. Twenty (74) of al cases\nwere mal, two couples wete repated and eleven cass (5S) had Asian eth One case reported seeking\nreoin on a single accasion and developed mid symptoms: al ather cases were hosptalzed, Thirteen (88) cases\neal had smoked hewn fora minimum of 3 yeas Testing of one avaiable heron sample Wdensed no\nsikiarice cihat Gon comuecis culting eerie.", "Aithough 2 speciic etiology wes not identlied our study supports Gee theory of an internMent exposure tos\njonc agent added to the herin ora combustion by-product. also suggests a dose response elect ater than\naeneticpredspostion, Calaerston wth pubic heath, heath profesional lw enforcement and persons who\nise legal rugs, wil facitate the erly ensicaton of cases to enable timely and compete fobowrup including\nSbaining samples. Tesing of implicated herein samples may all ientficaton ofthe contaminant and therefor\norevent further cases t Is therefore Important to ensure key stakeholders are aware of our findings.", "leukoencephalopathies [1]. Toxic exposure from heroin\ninduced leakoencephalopthy typialy involves the vec\n\nital lobes and cerebellum bterally, characteristic ey\nsssicic peocas cos es some ns neeabeacion EOE", "Leper prmipetny) Meters 10; Meee 0 he Wie Set\ner ofthe brain and therefore can involve motor, se\nory, and visu ystems, Leukooncephalopaty can als\nlsrupt cognitive and emotional function. There ae\nany etiologies of leukoencephalopathy, including\njenetc disorders, cetebrovasculat disease, elampla and\note exposures The dna! manestaton of the disease\nreflection ofthe areas ofthe brain involved in the\nlisease process. Clinical features range from inattention,\njorgefulness and personality changes, to dysarthria,\ntala, dementia, coma and death [1]; Toluene, ethane\ncaine, methylenediorymethamphetamine (MDMA o\nvecstacy”) and heroin have all been associated with toxie", "en re ee a\nsong hervin has beon recognized for over 25 year,\nthough the exact pathogenesis still not well under\nstood. In chasing the dragon, heroin is placed on\npiece of aluminium fol, heated with a flame from\nplow, and the resulting vapour (pyolyste) inhaled\nwth a straw of athertube-ke structure. The practic\nwat fie cecognized in Hong Kang inthe 1950 but ha\n\"ow spread te users worldwide [6h", "Albough the practice of ‘chasing the dragon’ i net\nuncommon, the associated leukoencephalopathy has\npeen carly reported The Get and largest cutheak of\nJeukoencephalopathy linked to chasing the dragon was\nTepuctel SOUS tn tus Pottoman endl ncieaed &F", "tana A Euacton “\", Renee Sebastian”, Lome Clearsicy’, Natalie Angus, Lena Shah”, Marcas Len’\nsian D Spacey?", "Chasing the dragon - characterizing cases of\nleukoencephalopathy associated with heroin\ninhalation in British Columbia", "Abstract", "introduction" ]

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[ "Synergistic effect of paclitaxel and epigenetic\nagent phenethyl isothiocyanate on growth\ninhibition, cell cycle arrest and apoptosis in breast\ncancer cells" ]

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[ "", "rnp (Topcee a 27; Anderson et 209; 2\n\nma Mec 31; Andere a eds, 3), revi ae\noe expen pr thee, cepa, a neato\nrest wh (gery ea 207; Wh and Valin, 2004\nfpane et 2017 ut tay 205 Pre tl 2012, One ga\n\nste sy with oes group ane oie the opal age\nSendo teament potas for deren bat hens ere\ner er experience ad eed potas tht wee developed on\nne ass os porate survey (os der ana).\nling sty soda ania eatin of hs develope\necon mena ean care ions 10) Thy a\nne erate sever unique fexture The say ft examined the\nepi pectin on burlap\nio a far depen. The ay empayed » guna tery\npond approach gin idee igh and abdrened ere! do\nmsn of avin hang yntervewing te esp afer hey", "The aim of tis exploratory pilot study was to generate hypotheses\nentity alias scl bars for plemening a 12-ecks\nrect pon he pecepns of tied peas who exper\ncf pon of te eset esi ne", "he Earopean Projet ECOMPARED (i stpuraa), that Wa\necient fs bended een stent sree ih ropes\nnie ilar cl 2010) The mai ejecie a Germany\nPT far ad ith ago of jer Depreie Dorr (MDD\nesr orem ean (FAL) rary cre BY a a\nfared by pcnogs in 2 ply andl atin univer\nne TAU war the roti ere patent eee by GP te es\nnhl eel oes en bray 2018 o Aug 206\nidan sigond abe rent canine TAU (n= 7) BO\nado", "The stody was approved by the ethics committee of the German\ncity of Pciogy (DG) and veitere in the German Cline\ni Reps (000K on December 2014). erp", "iho ope he dies te whl he ae\nsmc i sa ecp ah nd", "wher oie: Ibarananoraie character (ese 2)\n> yeanngs an aerave eaten! fo peal practioner\nthe Geman hats ere se. The psn provided sc\nrestment mle hteeork exec oed pg» led,\neoiging eye. A thera poral eabed heaps fo met\nce uns ene ue, vide ech om tr", "The patients treated by he interviewed therapists of this study\nWV = 72) were on erage #4 (SD = 13.16 Range = 19 1070) yar\nay female (82), igh eduested (5399), and ad pal\nob sh) 718% had no carer xprence wih peychothey 0\npts epee li 2 eon, 75 al ten enine sos\nfy had 7 ff seine on serge (0 = 1.6, ange 1 6)\nnelees eam es Reese dn as ohana", "sed meron. Thee clot parte benef nero\nsia. tect eceaestia, es or ahtaaee endich in da uadlanue", "AM Participants were women, young (d= 22.40 years old,\n= 28 ed ain dpe pg i\nTar ate enperince a hap war 2 month (SD = 28.39)\nboa revo erperence a BY oe oh) Thy wer empl\nsen May 2018 and Desens 20%6 sod tenet ave\nets wih or prenion All he herp ete ae th\nit prtcl ander the person of am experienced, ered", "sod te ees buns Rae on online of fu omic oe\ndeny bares and faites (Cael, 200 Compl et 2\nhand beige ap bene eveach ad pace aes\na.", "The interview guide was developed after 9 Bterature review 2¢-\nring tothe there dmains emer (TDF) wi 4 do\npotential ever eerie (se 201) and hay\nsox Sails fl anid UE: Gicuglen? emcees ol Lecco oo", "tenple characteristics of expert interveew perticipernts.", "Senate emennietee oferpen tanetes penigome,\nTerni epee Sees\nScart sis\nSeedpeer eau", "", "2.1. Design of the nal", "", "2.3. Participants", "2.4. Design of quatitarive study and data collection procedures", "" ]

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[ "file 1: Figure 51). At the 15-month time point, all groups\nof animals showed siniar performance on the running\nwal but witha light increase inthe steady state lee\nnf the hormone treatment groups (See Additonal le\nFigure Sib).", "Sontrals reached the platform (Figure 3b). This find:\nng may indicate that Al reduces cognition and epi\nearning aby. Supplementation ‘with E plus P and\nAl improved cognition and spatial leering ability t\nhalter tials, which showed a positive elective of\nE and P treatment (Figure 3b). The most effective\nhormone treatinent combination was E pls P pls T\nsteady state and cycle hormone treatient mimic\nng estrous cycles, which showed ~80% improvement\nnthe learning memory of mice (Fgute 3b). Further\napproximately 70% of animals reached the platform in\nhe E (40 pglnl) plus P (6 age), F (100 pa/ml)\nlas P (6 ngiml, and menstl levels of hormone\nreated groupe (Figure 3b).", "vO access spatia’ “earning ability: We used’ water maze\nexperiments Intaly al animals showed comparatively\nsual cagivebehvioe with to 16% of animals reach\nng the platform (Fue 3). Aer the wis, mice tated\nvith AU showed the las improvement in spatial lat\nng memory because only 34% of animals succeeded\ni encanta Ghote ohana 0h of cnmieriemtant", "Aland hormones acpording to the experrmental setup described in igure { in Methods Tumor growth was measured twice a week and\nareca or an mee eshed +P hea Pr (oa) nd EP Merl mer te hr ae\natl Ec ch tes sore uy ftir and ened heath tie de oncom ened mi\nrated mce sed eth cana tru the pried E+?) na EP (UO up ana owe a eh\ncorre ae ee ot tans ety ea bee ee", "2 0)\nin LE eee\nz Sr he oa\ninl La\n: ee snd\n5 200 PAF =\n\n. shel\na sti\n\ni =\nass a a)\n3 ee\n\n3| Zo aria\n\n7 mau\n\naetoa tia ie ieee ioctl", "" ]

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[ "Gackgroun® In our previous stucles, we Pound that the le334Thr SNP in the melanapsin gene (OPN) was\nfunctional assodated with the puplay light reex This indates the possiblity that OPR¢MTE3OTHr is associated\nwith ther nor-mage fring responses. The im of hissy was therefore to determine whether CPIM# e394\ns associated with sleep/wake timing,", "bien fader! shen gle atatarkartvai: earache corti ineh cok alah ine ad ss aaa ahah\ngenotype the le304Thr SNP of OPN Sleep habs, including bectime, wake ime and sleep duration, were asesed\nepartly fr weekays and weekends A total of 328 samples, including 273 samples wih TT genotype, 91 with\nTe genotype and 14 with CC genotype, were used for sata analy No igrvicant eifleence nage of male’\nfemale distribution was found among the three genotype groups,", "Results: There was no significant dilference in circadian preference among the genotype groups. During weekiclays,\npecime, wake time and midpoint of sep for CC subjects were signa ater han thes for TT and TC subjects\nHowever, there was no dfference between TT and TC subjects in ary of ther sleep has. Dutng weekends, bedtime\nof CC subjects was signcay ater than thos of Tard TC subjects, and the midpoint of sleep of CC subjects was,\nsignificantly later than that of TC subjects.", "Comcieeiemes Our Encinige Copmncisiriec’ Bigt CPW Re soe Ta is srscciete! wis Menges tening, Wie eo Kare) tet\nthe sleep/wake timing of subjects with the CC genotype was later than that of subjects with the TT or TC genotype.", "Keywords: Genotype, Human, Melanopsin gene (OPN4), single nucleotide palymerphism (3NP}, Non-image forming\nresponses, Sleep.", "important as, OF even more important than, that of the\n“sssical photoreceptors (rods and cones).", "wistanopsin, @ photopigment contained’ in a small subset of\ntinal angio cel plays an important ele n0-mage\njorming (NIE eesposes, including ceadan photoental\nnent [I] elton suppesion [2], pupllary light ete\nSal sleep behavior (5.65) and alertness [7.8], by tase\ning phate inadance Infomation to the ben. Parl\nules using genetic ablation of melanopia (Op) i\nice (19), using a slent-subsutin eethed hur\nfj, and using blind subjects [101] have. denoted\nhat the contribution of melanopsin to NIF responses is as", "Se ee eee oe ee ee\nSNP (1079610) inthe melanopsin gene (OPNS) was\nancionally asocated with pupllary ght rex (PLR)\nand that subjects with diferent genotypes of He394The\nSNP showed diferent degrees of responsiveness to Hight\n12.1). Thus, OPN e394 Thr ght be a factor ivoled\ninterindividual differences in other NIE reponses de\npending om ight such as ceeadian phase-shifting but ths\nromaine unclear,", "SR ae a ee Se\nstained epilation with a period of about 24 hous. I\nfact the cada clock runs fre without entrainment\nsynchronization) to envionmental signals, expecially the", "sang-il Lee’, Akiko Hida*, Shingo Kitamura’, Kazuo Mishima* and Shigekazu Higuchi’", "Association between the melanopsin gene\npolymorphism OPN4*lle394Thr and sleep/wake\ntiming in Japanese university students", "Abstract", "Background" ]

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[ "The wee of aucrobetbie contrast can improve ding\nnostic accuracy for echocardiography, and has been\ned to enhance parenchymal tumor evaluation in ls\nal and research settings [13,1]. Contrast-enhanced\nultrasound (CEUS) enables visualization of vascula\nrehitecture in realtime, without exposing the patient\n2 soning radiation; this may be particularly advanta\nscous to populations in whom auch expoaure i of ca\nren (such 3 children) or in whom Serial examinations\nmay be necessary (such as patients with vasularmalfor\nations). These features suggest that CEUS may be use\nfal o supplement oF even replace MRI or conventional\nanglography in some istancea. We report the fist cat\nft which CEUS has been used to evaluate avascular\nalfoemation.", "welling in the sce, Initial HAR imaging demensizated &\nvasculae malformation (Figute 1). Arteriovenous shunt\nng sgnving some component ofan arteriovenous ma\njormation was suspected based on the presealing\ncomplaits and liieal characterises ofthe tense, sw\nJe lesion. Diagnostic arteriography showed a soft sue\nmalformation with dee regions of arteriovenous shunt\nng Sdenlfed, supplied predominantly by sual branches\nofthe right popliteal artery. Sonography with contrast.\n\nhanced and conventional two-dimensional (2D) colo\nsnd pulsed Doppler was performed to obtain addtona\nMtetiovenous shunt informstion prior to therapeutl\nseen.", "A 26-yoer-old womnea wich « anees in ler eight colt since\nfo ceo at 9 cremmrad With coniiniane pola ana", "Sonographic imaging was performed initially using a\nplips 1E58 ultrasound machine with 22D transduce\nS5-L1. 17 - 3.4 MH). The mlcrobubbe contrast agent\nDefinty Lantheus Medical, Billerica, MA) was pre\nsctivated for 45 seconds using « standard diffusion\nfevice (Vialmix, Boston Myers Squibb Medical Image.", "erale with a palnul taraiat malformation of he right lower eg winh a cincaly vous vers poerponent was valued for arteovenous,\nPuno (Pagal acing MR mage wh eran guru cate Severed a ee vax maton he\nit pacers anf gel rteonsngoy oe ntog steel pope ge and poe tae\n\nsi saleiaprinel cpanel ho, ayrhandnnp raat s brebtlade./yiny de famardins w nerves d adept", "1 A] res x |\nrae f A", "Methods" ]

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