Datasets:

dotan1111

/

MSA-amino-10-seq

like 0

YYYYYYYYYYILIIVIIIIIISITTIILTSTTTTTTTTNTEEEDEEEEEEVVVTVVVVVVRRRRRRRRRRNSSSSKNSTSYYYYYYYYYYRKRKKRRRKKCCCCCCCVTADENDDDDDNEIIVVIIIIVV----A-----VVVVVVVVVVAALAAAAAAAYFYFFYYYFFKKKKKKKKKKGDGGGGGGGGKKKKKKKKKKTMTTTTTTTTIIIMGVIIIIKKKKKKKKKKIVTVVVIVVVQQEEEDENEEGAEAAEGEAVSAAAAAAAAAQQQKKRQRKQGAAAAAVAAASSSSNSSSSLTHTTTTTTTH--------H-RRRRRRRRRRVVVVVVTVVVLLLALLLLLLLLLLLLLLMLQQQQQQKQQQALAAPASAAARRRRRKRRRRSSSGSSFSSSTAAASAAAAA

LLLLLLLLLLLFFFFLLLFFIVVVVIIVIVVIVMMIVIMMRRRRRRKRRRFFFTTFFFTTRKKKKKKKKKDDDDDDDDDDPPPPPPPPPPEAAAAEEAAAGGGGGGGGGGNNNNNDNGNNSTTSTSSSSSAAATTAAATTSTTTTTSTTTQKKLRQQKKKAAAAAAPAAASSSNSSSSSSMMMMMMMMMMAAAAAAAAAAAAAAAAAAAAMMIIMMMMMMPPPDDPPPDDDKKDDDDDDDLLLLLLLLLISSSSSSSSSSTEETTTVTTTGGGGGGGGGGQQQKKQQQKKRRRRRRRRRRKKKKKKRKKKLLLLLLLLLLIFFFFFFFFFVLLIILVLIILLLILLLLIICCGCCCCCCCIIIIIIIIFFNNNNNNNNNNKKRKAKKKKK

SSSSSSSSSSMMIMIMVLIMQQHQEQQQKNNNGGGGGGGGSSSSSSSSSSKKKAAAAAKAPPKKKKKKKKEEEEEEEEEEWWWFWWWWWFFFFFFFFFFFAAAAASSSAAHQQQQQQEQQIIIIIIIIMIQQQPPPPPQPCCCRCCCCCRDDNEEEEENEPPPTTPPSPTAAAAAAAAVAGGGGGGGGGGLLLLLMLLLLEADEEEEEDERRRLLRRRRLPPPPPPPPPREEEEEEEEEEIIVVVVVVVVMMMMMTQMCLLLLLLLLLLLDDDDDDDDDDDDDDDDDDDDSSSSSSSSSSGGGGGGGGGGSSSASSSSGSRRRRRRRRRRSSSTTTTSSTEEDDDDDDDDAAAAAAAAAALLVLLLLLLLCSSSTSSPSTFFFFYFFFFF----F-----

YYFYYYFYYYRRRKRRKKRRITIVTIIILINGKKSKKESKWWWFWWWWWWPPAPPPAPPPLIIMIMIMIIVVVVVVVVVVAAAAAAAAAAPPPPPPPPPPQQQKQQQKQQTQTTQTTSSTEEEEEEEEEEDEDDEDDDDDVVALVLALVLGGGGGGGGGGDDDEDDDDDTRRRRRRRRRRGRGGLGGGGGLVLMLLLLLLGGGGGGGGGGEEEEEEDEEELLLFLLFLLLVIVHIIVHIVEEETETETETRRRRRRRRRRAAAGAAAGAALLLLLLLLLLWWWWWWWWWWIIIIIIIIIIPPPLPPPLPPGGGGGGGGGGWWWWWWWWWWSSSDSDSDSDILLLLLLLLL

SNSSSGSSASLIIILIIILILILLLLLLLVLLLLILLLILDDDDDDDDDPM-LLM-LMMMM-LLM-LLFLVAVVVAVVVVKNHHHNNNKNFFFFFFFFFFTTTTTTTTTTPPPPPPPPPPRRPPRRRRRKMVMMMVSNMNLLLLLLLLLLEEEEEEEEEEDEDDDETTDTSSSTSSSSSSSTTTSTTTSAYYYYYYYYWYSSSTSSSSSSEVAAVVVVVVIIIIIIIIVIAAAAAAAAAARRKKKRKKRKPPPPPPPPPPEEEEEEEEEEEEEEEEEEEEPPPPPPPPPPLLVLLLLLLLNNDDNNNNNNTTTTTTTTTTKKKKKKKKKRTEDDTDDDTD

YYYYYYYYYYSSSSSRASTSSAAAHAAAAAAAAAAAASAASSSTSSSSSSAAASATATAAPPPPPAPPPAQQQQQQQQQQFFYFFLFFFFLILLILILILPPPPPPPPPPFFFFFFFFFFLLLLLLHLLLMMMLMLMLMLPPPPPPPPPPKKKKKKKKKKDDDDDEDDDDRRRKRRRRRRLLLLLVLLLVIILLILILILGGGGGGGGGGGGGGGGGGGGHHHYHYHYHYDDDDEKDDDRDDNDDDDDDDVIVVIIVVVIYYYYGYYYYYRRRRRRRRRKSGSSGSGSGSMMMMMMMIMMKIAKIKIKIQVVVYVYVYVYAAAAAAAAAANNNNNNNNNNLLFLLMLLIMYYYYYYYYYYWWWWWWRWWWDDDDDDGEDDKVKWVWVWVWTTTTTTTTTT

EEDEEDEDEEFFFFFFFFFFTTLLTVTLTLKKKKKKKRKKFYYYYYFYYYMRARRARARRRRRRRRRRRRLILLILILVLILIIIIIIIILLLTLELEQSGGGGGGGGGGDDDDDNDDDDNNNNNNNQNNPPPPPPPPPPNSNDSNNNSNLLIYLLLLLLRRRRRRRRRREEEEEPEEEELLLLLLLLLLSCCCCCSCCCPPPPPPPPPPLLLLLLLLLLRKRRKRKR-RDDDDDDDD-NVVVVVVVV-VNNNDNNNN-DRRRRRRRR-RFFYFFYFY-YVVVVIVVV-VKKKKKKQK-KNNGSNNNN-NSSSSSTST-SIVIIIIII-I

MMVMLLVMLMQQPPPPPPPQLLLILLILLLPPPPPPPPPPLLLLAKLMMLRRRRRRGRRREEDDEDDEEERRRRRRRRRRMMMMLMMLLMKKKKKKKKKKAAAAASAAAACCCCCCCCCCDEDDDDDDDDHHHHQHHHQHYYYYAYYAAYEEEEDEEDDEIIILLIIILIIIIIIIVIIIFFFHFHFFFFAAAAAAAAAAVVVVVVVVVVDDDDDDDDDDAVSNSSSSSVQQQQQEQQQQSGSSSSSSSSVVVVVVVVVVGGGGGGGGGGDDEEDEEEDDTTPPPPPPPTPPPPPPPPPPDPVVTTVTTPEEKEEEKEEELFLLLLLLLFFSLLFFLFFC

KKEKKKKKKKYLVLLLLLLLSSASSSSSSSSTSSSSGSSSCCSSSCCSSCVVVVVVVVVVRRRRRIRRRRMMLLLMMLMMFFLFLCLFFVPPPPPPPPPPLLLLLLLLLLRRRRRRRRRRGAASAAASAAGGGGGGGGGGLLLLLLLLLIAAGGGAAGAARRKTKRRTRRGEAAAEEGSAKKRKRKKKKKGGGGGGGGGGIIQTQII-QIIILIIII-IIWYLWWWYWWWSSSTSSSTS-CCCCCCCCC-GGGGGGGGGGEEEKEEEKEE---------P---------S---------D---------S---------D---------M---------I---------K---------S---------A---------N---------V---------I---------V---------N---------P---------I---------A---------E---------W---------K---------R---------A---------S---------L---------Q---------Y---------K---------Y---------L---------V---------W---------V---------K---------KGGGGGGGGGGILIIIIIIIIEEEEEEEEEEAA-A-AAASDPP-P-PLPPPII-I-VIIIISGSSSGGSRSYYYYYYYYYYPPPPPPPPPPAAAAAAAAAAVVVVVVVMLICTTTTTTTATKRKKKKKKKKSSAAASSAASLLLLLLLLLLAARARAAAAP

HFHHHFFFFFPVPPPPVVVPGGGGGGGGGGTLTTLLLLLLLLLLLLILLLYYYYYFYYYFNNNNNNNNNNVVVVVVVVVVEEEEEEEEDERRRRRRRRRRNNSSNNNYNNSSSSSSSASPQVQQTRIVVRAAASAAAAAASSASASSSSSSTSSSSSTTSYFFFFFFFFFPAPPPPAAAQMIMMMTIIIMLLLRLLLLLLAAAAAAAAAAKSKKKSSSSSVVVIVVVVVVWWWWWWWWWWIVIVIIVVFIGGGGGAGGGGLILLLLVVVLTATTTAAPSAPPPPPPPSSTTETHTSEEETTTTTTTTTATIILLIIIIIVDEDDDEEEEEPSSSSSSSSS

FILMLMVIIQKRKRRKRRRKRRRRRRRRRRNDNNPNNPNSSSSS-SS-SSIIII-II-IIGGGG-GG-GGGGGG-GG-GGPPPPPPPPP-HQHQQHQQQ-FFFFFFFFF-TTTTTTTTT-TTTTTTTTT-YFYFFYFFF-LTLLSLTSS-VVVVVVVVV-SSSSSSSSS-NNNNSNNSNNKKKKNKKNKKTTTTTTTTATPPPPPPPPPPTTTTSTTTTTGGGGGGGGGGIIILIIIIIIH-HS-HS-SHVIILIIIIIVTSTTPTTPTSQRRRRRRRRRLLLLLLLLLLILILIIILIISATAATAASSSNNNNNNNNNIIIIIIIIIIFFFYFFFFFFHHHHHHHHHHEEEEEEEDRELALAALAAALEEEEEEDEEEAQAAQAQQKAGGGGGGGGGGAAAAAAAAAELLLLLLMLLLLMLIMLMMIL

DADDDDADDAWWWWWWWWWWLLLLLLLLLLTTAATTTATALLLLLLLLLLDEDDEDEDEDRRKKMRRKRKLIMMIILMILGGGGGGGGGGKQ--KKK-KK-L--LLL-L--V--VVV-V--R--KKK-K--N--NNN-N--Y--YHY-H--I--IVI-I--E--SSE-S--M--MMM-M--G--GAG-G--R--RRR-R--A--AAA-T--A--AAA-A-EA--EEE-EEAG--AYG-GTII--III-IIEE--EEE-EEWW--WWW-WTGG--GGG-GGVV--VVV-VVSG--GGG-GGPP--PPP-PP-A----A-A--T----T-T--R----T-T--H----H-H--F----F-F--I----I-I--L----L-L--A----A-A--Y----Y-Y--N----N-N--N----N-N--V----I-I--V----V-I--P----P-P--A----A-A--K----K-K--K----K-K--V----L-L-TTSSTTTSTSKQKKKKQKRKCCCCCCCCCCSSSSTSSSSSKKKKKKEKKKDGDDEDGDDDIIIIIIIIIIEAAAAAAAAA--EE---E--EEEEEEEEEEAAAAAMAAAAEEEEEEEEEAAAAAAAASAAVVMMVVVMVM--RR---R-RSASSAAASASTMTTTTQTMTKKKKKEKKKKDEDDDDDDDDNNNNNNNNNN

NNNNNNNNNNAAAAAAAAAAPPPPAAAPPAYYYYYYYYYYLLLLLLLLLIQQQQQQQQQQLLLLLLLLLLPSSSSSSSSSLIILLLLILLSTSSSSSSSSIIIIIIIIIILLILLLLMLLDDDDDDDDDDPPPPPPPPPPSILS-S-ASSEQQE-E-EEEGGGGGGGGGGKRRRRRRRRRPPPPEPEPPPVIIVVVVLVVNNNNNNNNNNLLLLLLLLLLRRKRRRR-RRLLLLLLL-LADDDDDDDDDDEETEEEEQEEETTQEQETTQPPPPPPPPPPNNNNNNNNNN-LLLFFFLLF-HHHLHLHHS-IIIVIIIII-AAAAAAAAA-DDDDDNENDASSAAAASSA

IVIVIIIVVVSSAVSSSSSSVVVEVVVEEVWWWQWFFWWWEEEEEREEEEVVVVVVVVVVLLLLLLLLLLKKKKQQQKRKEEEEEKEEEEQNNNNNNNNNLLLLLQLLLLRRRKRTTRRRRKRRKQKRRKDDDDDDDDDDAAAAAAAAAAEEKSEEEEKESSSSSASSSSGGGGGGGGGGTGTSSSSSSSSSSSSTTSSSATASAAASSAIFIFLLLFFF-------E---------Y---------R---------S---------W---------D---------I---------T---------H---------L---------L---------E---------P---------I---------A---------L---------D---------G---------L---------Y---------P---------C---------E---------G---------G--RRRRRRRRRRRRRKRRRRKRMLMLMLLLLLIVVVVVVVVVSTSNSGSSSSVVVVVVLVLVQQQQQQQQQQPPPPPPPPPPTTTTTTNTTTGASAVVVMSAKNKKKKKKKKAMVMMMCMMM

GGGGGGGGQSRRRRRRRRRRNDDDDEDDEDLLLLLLLL-LMIMMMMMM-MCCCCCCCC-CALLLLVLL-VCCSI-C-C-CIIVVIIII-IKKTTKKKK-KPAAAAAAA-AAAAASAAS-AWYYYWWWWWWSGQQSSSSSSDDDDDDDDDDYYYLQRQYRYLLIILLLLLLEEDEEKEEEEKKKKKKKKKKKKKKKKKKKKHHHHHHHPHHPAAAAAAAAPLLMLRLSLLLVVVVVVVVVVDDDDDDDDDDIIIIVIIIILIIIIIIIIIINPPPNSNNNNTTTTTTTTTTTTTTTTTTSTKNKKKRKKRKHHHHHHHHHHDDDDNDDDDMSSLLSSSSSSEEEEEDEEEEKKKRKKKKKKAAAAAAAAAALLLILLLLLLGGGGGGGGGGTTTTTTTTTTLLLLLLLLMLKKKKKKKKKKHHLLHHHHHH

MMMMMMMMMMQ--Q--QN--MMMMMMMMMMLLLLLLLILLKRRKRRKKRYKPPKPPKKPPYYYFYYFFYYNHHAQNDDHGVVVVVVVVVIKKKKKKKKKKSTTSVVSSVVVVVVTLVVALEVIEVMEEVVAAASAPAAAPDDDDDDQDDDILLAIIGALITTTQTTEQTTKKKKKKKKKKAAAAAAAAAAPPPPPPPPPPEEEEEEEEEEANNANNAANNNCVNNRNNNRVEEVLVVVEVEEEEEEEEKERRRRRRRRRRRRRRRRRRRRKRFGRKGGRKVVVVVVCVVVVLLVIIVVIITTTDTTADTTTVVTIIDTVI

KKKKKKKKKKTTTTTTTTTTVVVVVVVVVVLLLLLLLLLLHHNNHNHNHNRRRRRRRRRRQQQQQQQQQQRRRRRRRRRRREERKERRKEYYYYYYYYYYVVIVVIVVVILYYLLYLLLYPPPPPPPPPPLLLMLLLLLLQQQKKQQKKQQQNQQQQQQQFYYFFYFFFYVVAVVAVVVVVIILIIVIIIDDDDDDDTDDWWWWWWWWWWNNNNNNNNNNSSSSSSSSSSPPPPAPPPPPNNNDNNNDTNERRRRRKRRR---FF--FF----AA--AA-E-EEEEEEEE-------K---------T---------T--I-IIIIIIVIANNNNNSNNNVVVVVVVVVVWWWWWWWSWWPLLILLPLLLGGNGGNGGGNQQQRQQQQHQLLLLLLLLLFDDDDQDDDKEKVVMMVKMADAKKATKAATKKKKRRKKQRKPPPKPPPVPPREERRDRRRE

VVVVVVVVVVLLLLLLLLLLFWWIWWASWALAGLGLLLALPPNPNPP-PPRRRRRRRRRREEEEEEGEEGDQQDQQQQQQQQQQQQQQRQFFFFFFFFFFQKKTKQQQKQKNKKKKKKKKWWWWWWWWWWLLLLLLLLLLLLILLLVLLVNPDDDDDDDDGGGGGGGGGGKKKKKKKKTKDDNDNDDDDDRRRRRRRRRRFYYFYYFLYFSTTTTTTTDTAAAASAAAAADDDDDDDDDDPPPPPPPPPPQPEQEQQQQQLLFLFFLLFILLLILLLLLLPPPPPPPPPPSSSSSSCCSCDDDDDDDDDDEEEEEEEEKESSASSSLCSSPPPPPPPPPPDTTDTSDDTDPPKPKPAAQGKKKKKKKKKKFFFFFFFFFFFVVVVVVVVVIVIIIVVVIVAQAAAAAAAA

EDEEEEEDEEG-GQGGE-GEA-A-A-----V-I-I-----D-D-D-----T-T-T-----G-G-G-----Y-Y-A-----A-A-S-----P-P-P-----N-N-N-----T-T-T-----R-R-R-----G-G-G-----L-L-L-----V-I-I-----F-F-F-----LVLLMMLVMLLLLLLLLLLLYLFYFFYLFYMIMMMMMMMMQHQQQQNQQNDDDNDNNDTNDDDDDEDDDDGGGAGGGGGAIVIVIIVVIVTETETEEEEEWSWWWWWLWWVSVSVSSSSSQQQQQQQQQQPSPPPPPSPP----Y-----QQQQQQQQQQGGGGGGGGGGATAAAAATAA-D-D--DD-D-E-E--EE-E-G-G--GG-G-Y-Y--YF-Y-T-T--TT-T-G-G--GG-G-N-N--NN-N-D-D--ED-D-A-V--AV-A-V-V--VV-V---Q--K--K-S-G--GG-G-N-K--TK-K-A-V--VA-V-P-P--PP-P-E-E--EE-EEEEDENEEEETTTQTTTTTTLLLLLLLLLLPPPPPPPAPPDDDEDDDDDDEEEEEEEEEEPPPPPPPPPPKKKKKKKKEKVVVVVVVVVV

DDD-DDDDEDQQQ-QQQQQQNNKNNKKKKKTTGKGGNGGGEDDEDDDDDDVVAVVAVVVVDDDDDDDEDDLLLLLLLLLLEEVEEEEEEELLLLLLLLLLNNNNNNNNNNTTTVTTTTTNNNNNNNNYNYMMMMLIMMMMVVVVAVVVVVLLLLLLLLLI----T--S-S----Y--Y-YGGGGGGGGGGLYLLLLLLLLEQEEEEEEEELLVLILI-V-ETSSASS-S-SSSSSSSSASVVVVIVTIVITSKTKKKKKKSSSSSSSSSSDDADDADDMDDDEDEEEEEEAAAAIAAIAIVIILILIIIIVVVVMTVVVVVVIVIVA-VIMMMMMMM-MLAASASSS-SSPPAPFAPFAFYYYYYYYYYYTTTTCTCCTCKKQKKQKKRKLLLLLLLLLIGGGGGGGGGGNNNNNNNNNNSSSSTSTKHK

AAATAAATAANNNNNNNDNNFFFFYFYYYYPPPPPPPPPPLLLLLLLLLLQQQQQTQQQQRRRRRRVRRQVVVVVVVLVVKEE-EEEEEEVVVVAVGVVAFFFFAIFFFFTSSSNSSSSNFFFFFFFFFFQQQQQQQQQQSSSTSSSSSSPPPPPPPKPPDDDEESEEEEPPPRRPRHRRKKKKQKKKKKQQQQQQQQNQTTNTTTTTTTVVVVIVIVVIYYYYYYYYYYVVVIIIIIILAAAASAAAASITIIFIIIIFWWAWWWWWWWVVVVVVVVIVWWWWWWWWWWILLLQLQLLQCCCCCCCCCCQEQQQQQQQQQQQQQQQQQQYYYYFYYYYYMMMAMMMMIMWWWWWWWWWWIVVTIIIFIIGGGGGGGGGGDDEDDDDDDREEEQQEQQEQLLLLLLLLLL

RRRRRRRRRRPPPPPPPPPPAAAVAKAAKKYFYYYYYYYYLAAACAAAAAAAAAAAAPAAIALLLLLLLIFYNYYYYYYYIIILLLILLLAAAKKKKKKKCCSCCCCCCCLLLLLLLILILLLLLLLLLLYYYYFFYFFFAAAAAAATTAGGSGGGGGGGDEDEDDDDDDAHAAAATAAARRRRRRRRRRNNNNNKNNNNYYYYYYWYYYFFFYYYYYYYGGGSGGGGGGYYYYYYYYYYIVVVVVVVIVIIIIIIIVVIFFFFFFFFFFLLLIVIIIIIDDDDLDDEDDRKKKKKKRKKRRTRRRRRRRHHHHHHHHHHRRRRRRRRRRKKKKEKKKKKTCTTTTYTTTSSSSCSSSSSTSSSASSSSAGGGGGGGGGGCCCCCCMCCCYYYYYYYYYYKKKK--KKK-

--LLLLLLLLDDNNDNNNDDHHHHNHHHHHSSSSAASASSSSVVAVVVVAFFFFFFFFFFFFFYFFFFFFDDDDDDDDDDTTTTTTTTTTAAAAAAAAAAVVVIVVVVVVVVRICIL-MCAAAAAAA-ATNENNNWNWNNLLLLLFLLLLIVIIIIIMIIFFFFFFY-FFRRRRKRR-RRRRT-R-T-RRITI-I-I-IIAAAAAAA-AACCCCCCCCCCAAAAAA-AAAQQRIMI-IIIYYYYYY-YYYVVVVVV-VVVLL--------SSSPSP-PSSVVLVIV-VVVEEGGED-DGGVVLVVI-IVVGGSAGS-SGGKKKKKK-KKKPPPPPP-PPPRRRRRR-RRRGGGGGG-GGGIII-I---IINNYNTN-NNNGGGGGGGGGGQHQQQQQQQQAASAAAAAAAGGGGGGGGGG

AAAAAGAAAAVVVVIVIIVVCCCCCCCCVCEQQEEEEEEEGEENNNNNNGLVLLLLLLLLPPPPPPPPPPLLLLLLLLLLKKKKKKKKKKNRQQQQQQQDGRRVRRRRRRLLLLFLLLLLIVVVVVVVVIKKKKKKKKKKRRRRRRRRRRDEESEEEEEQAAAAGAAAAAFFFF-LLLFFLLLL-LLLLLAAVAAAAAAAKKKKKKKKKKHYYHHHHHHHDEESEEEEEDNSNNNNINSNKRKKKKKKKKQQQQRRRRQQCCCCAAEACVKKKKK-KKKRVIIII-IIIIYFYYYYYYYYKKKKYKKYKKRNNRNNDNNRTSATAAAAATIIVIIIIILIAFFAAAAAAAHHQHHQHHHHDEDDDDDDDDIAVIVVVVVI---F---------S---------R---------D---------E---------E---------A---------V---------D---------M---------T---------L---------T---------Q---------R---------R---------E---------G------CLLCCCCCVCVVIVA-IIIVNNNNNNNNNN

DDDDDDDDDDYFFYYFFYYY-QQ-QQQ--Q-II-III--IHRRHHRRHHHRRRRRRRRRKRRRRRRRRRREEEEEEEEEEFYYYYYYYYYTTQTTQQTTTNRRRRRRRDRSSTSSSSSSSHHYHHHYHHHLIILIIILLILLLLLLLRLLDDDDDDDDIDSGGSGGGVSSSRTASTTSSSDSPSSSPSDA-AQ-EEQ--E--L-------EVVEVVVEEEMAAAAAAMMAIIIVIIIVVIHSSHHSSHHHLHALAAALYA-RRRRKR--R-QQEQQQ--QLLLLLLLLLLDDDDDDDDDDRRRRRRRRRRTNNNNNHNTNDDDEEDDTDE-HVVIVVI-A-WWWWWWW-W-SSNNASN-N-----S-----QQQQQQH-QQNNNNNNQQSKKKKKKKKKKRRRRRRRRRRDDDDEDDNDDNQQEQQQNNQQQEQQQEQQQVILAVLLVVVKKLKKLLKKKGGGGGGGGGGPPPPPPPPSPHHGHHHGHHY

IIIIIIIIVIKRRRRRRRRRPPPPPPPPLPWWWWWWWWWWRDKKKKKKKRFLLLLLLLLLVLVVVVKVVVMCCCCCCCCMEEEEEEEEEDYYYYHYLYYYLLLLLLLLLLGGGGGGGGGNHHYHHDHHHHGGGGGGGGGGSSASSSDDSSFFLFLFFFYFNKNNNNKKNNLIIIIIIIILSRRRRRRRRREEEEEEEEEERRTNTNNNNRIIIIIIIIIINNNNNNNNNNHHRHRHHHHHDDDDDDDDDDKKKKRKKKKKPPPDPNDDDPPPLFLLLLLPWWWWWWWWWWYYYYYYYYYYIIIIIIIIIIHHHHHHHHHH

LLLLLLLLVLRRRRRRRRRRKKNKRKKKRKWWWWWWWWRWFFFFFFFFFFSNNESSNNNNLLLLLLLVLLRRRRKRRRRRRQKKKRKKKKDNNDDDNNDDTTTTTVTTTTLIILLLIILLGGGGGGGGAGGGGGGGGGGGGGGGGGGGGGGTAGGGGAGGIVGIIIIGIIMMMMMMMMMMGAASSSAMAKEEEEEEEEEE-------C--KEEEEEEEEAAAAAAAAAAAKKEKKKKKKKDD-DDDD-DDYY-HYYY-YH-----V---------S---------T---------I---------A---------K---------P---------T-------S---------L---------F---------L---------T---------A---------A---------N---------L---------T---------P---------A---------R---------G---------L---------L---------W---------A---------A---------R---------L---------H---------S---------V---------S---------P---------F---------L---------P---------A---------L---------T---------Q---------P---------N---------V---------T---------Q---------A---------P---------F---------I---------R---------V---------S---------IV-----TSRTTTDSTTIIIIIIIIIIGAAGGGAAGGEDDDDEDDGDNDGSSDDGDDRQQRRRRQRRPPPPPPPPPPVVVTIVIVAVVVVVVVVVVVSGGSSTGGGGSSGSSASGSSPPPPPPSPPPSQQSSAQEQQ-------R--

LLIVIVVILVAAAAAAAAAAAVPPPPPPPP---GGGGGGGIIIVVVVVVVILIVIIIIIIGGGGGGGGGGIIIIIIIIIIQQQQQQQQQQLLLLLLPLLLVVVVVVVVVVLLFFFFFFFFTTTEEEETTEWFWWWWWWWWHHHHHHHHHHTTTTTTTTTTKEKKKKKKKK---KQKKL-L---PPPPP-P---LQQQE-Q---MMMMM-M---APRQP-P---VVVVV-V---TTTTT-T---RRRRR-R---GGGGG-G---QQSSE-Q---AAAAA-A---GGGGG-G---DAAAA-A------L------AVAAA-A---LLLFM-T---GGGGG-G---YHYYH-H---AMVVV-V---VVVVV-I------W------RRRRR-R---LLLLM-L---GAGGG-G---YYYYY-Y-------G-----LLLLL-L---LIIII-I---IIIII-I---DDDDK-E---SSSSS-S---PPPPP-P---RRRRK-R---PDQDD-D---AAAAA-A---SSSSK-S---DDDDD-D---VVVVL-L---QSQQQ-Q---EDDED-D---GGGGG-G---QEEEE-E---GGGGG-G---LLLLL-L---YYYYY-Y---CICCC-C---SSSSS-S---IIIII-I---YYYYH-YTNTTTNTTTTMIMMMMMMMMFFFFFYFFFVQQQRQRRQQQYYLRRRRHYRLLLLLILLLLGGGGNGGGGGMMMMMMMMMMMMMMMMMMMMLLL-------RRGSSSSSTS-K--------LLLLLMMLLL-----SS--------KK--------KK--------GD--------VV--------PP--------II--------FF---ASAAAAAAAAVIFFFFFFFFLLLIIMINIIIIILIIIIIIVVVIVVAVVVFFFFFFFFFFYYYYFFMFYFIIAMMMMMMMTTTTTTTTTTMMMMMMMMMMYCACCCCCCCCCCCCCCCCCEEEEEEEEEE

EEEEEAEEEETTTTTTTTTTLLLLLLLLLLSSLESSLSASSSNSSSSSSAVVVVVVVVVVVTTNTTTTTTKPKKPKKEKKFLFLLLFIFFLLLLFLLLLLQQQQAQQQQQILLMLFLLILIEIIEIIVIIDDDDNDQDDDLLLLLLLLLLSSSSSSTNSSVEQEEEKEEKTLLVLILLTLVIVIIIVIIVFFFFFFFFFFWWWWWWWWWWKKSKKKKKKKESESSSESEEVVVIIIVVVVQHQKQKTQQQPPPPPPPPPPAAAAAAAAAAWWWWWWWWWWDDDDDDDDDDTTTTTTTTTTKKKRKKKKKKSASSASSSSA-C--C-----ILIILLVLILIIIVIIIIIITSSESESSTGSSSTSSSSSAYYYYYYYYYYSSSSSSSSSSFFFFFFFFFFLLLLLLLLLVEDQEDEQDEQCCRCCCCCCC

TVTAVVTVDTIIIIVVIVVIEEEEEEEEEESNGGNNKNNGQQQQQQQQQQNDNNDENDNDDDNDDDDDDDTTVVTTTTTIFFFFFFFFIFAAAAAAAAAAILIILLLLIIMMQIWMMWMMDDDDDDDDDDDDDDDDDDDDILIILILLIIAAAAASAAAATTTTTTTTTTTTTVTTTTTTKSKQ-QQQQQDDDDDADDDDTDTTEEDETTHHHHHHHHHHVVVVVVVVVVEEEEDEEDEEEQQQQQQQEQVVVVAVVTVVNNNNGNNGNNCIIAIIIIAIPPPPPPPPPPRMRRMMQMRRKKKKKKKKKKAAWAAAAAAADNTTAADADT

LLLLLLLLLLEEEEEEEEEEVMIILVIIIITVVVVTVVVVEEEVEEQEEERRKRRRQKLRLLLLALLLLLYYYYYYFYYYSAGAASAGSAEEEEAEEEEEKKKRKKQKKKRRTRRRRRRRQQQQQQQQQQTCCCCQCCCCASAAAAAAAANHRARNKRNRVAAVVVVAVVEAEEEQEEEESSSQSSSSSAPPPPPPPPPPEEEEEEEEEEGAGTGGTGGTIILIVVIIVILLLLLLLLLLLLLMLLLVLLQKQQQQQQMQRRRRRRRRRRQQQQQQQQQQGGGGGGGGGGNNNDNSNNNNCCCCCFCSCCEQQSQESQQQQHHKKQKHQK

TTTTTTTTTTLLLLLLLLLLAAAAADAAAAEEEEEDEEEEDDDDDDDDDDEEEEEEEEEEDDDDDDDDDDTATVTTATTAVIMVIVVVLVSVSSSSTSSVTTTTTIVVTTRQRQQQQQQQDDDDDDDDDDSTSWTQTQKTIIIIIIIIIIP-PPPP-PP-AIAYYYYYAIEEEEEEEDEEAAAAAGAAAAIIIIIIIIIITTTVTTVTTTLLLLLLLLLLQKQKKKKRRKYFYFFFFFFFETASTATAATYHYYYYHYYHMIVMMMMKMMIVIVVVVVIVRRRKRRRRLK-P----P--P-L----L--L-V----V--V-L----L--L-D----D--D-Q----Q--Q-S----S--S-Q----Q--Q-E----E--E-C----C--C-I----L--I-L----L--L-G----G--G-F----M--M-I----I--I-A----A--A-V----V--V-S----S--S-G----G--G-L----L--L-H----N--H-G----G--G-V----V--V-V----V--V-I----I--I-I----I--I-V----T--V-A----E--A-P----P--P-E----E--E-D----E--D-E----E--E-M----M--M-E----E--E-F----F--F-A----A--A-A----A--A-K----K--K-L----L--L-I----V--I-L----L--L-V----V--V-E----E--E-W----W--W-R----R--R-D----D--DKQKKQKQKKQEDEDDDDNDDRKRRRRRRRRTTTTTTTTTTKKKKKMKKKRL-LL-L-LL----M------NDNDDDDDEDDDDDDDDDDDFYFFFVYFFYACAAAAAAACDVDDDDDNDVEEEEEEEEEERRRRRRRKKRSASSSSASSA

AAEAAAAAAADDDDKDDDDDFFFFFFFFFFSASSSSFSSS---V------DDDDEDEDDDVFFFFFFFFFCCCCCCCCCCI-VLIIII-IS-SNSKSS-SK-KKKKKK-K------E---I-VVVIVV-VEEEEEQEEEEQQEQEQEQQEKVVKKKKKVVRRRRRRRRRRTTTTTTTTTTQQAQQQQQQSEEEEKEEEEE-R---------E--------PPPPPPPPPPWWWWWWWWWWSSSSSSSSSSIAAIAIAAAAPPPPPPPPPPIIIIIIIIIILLLLILLLLLRRKRRRRRRRFFFFFFFFFFMIIIVIYVIIAASAAAAAAA------I---------E---------V---------F---------E---------R---------Q---------K---------S---------D---------D---------P---------R---------S---------T---------G---------D---------L---------R---------P---------N---------N---------I---------F---------V---------A---------Y---------E---------K---------S---------D---------V---------K---------R---------D---------V---------E---------I---------V---------E---------N---------N---------L---------L---------R---------L---EEEEEEEEEEDDDDDDEDDD---------A---------V---------I---------E---------NAATAAAAAAAVVVVVVVVVVEAEEEEEEAEATTTTTTTTTAAAAAAAAAA--P-------EQEEPEPEQEKTTKRKNLTTQQQQRQRQQQSTTSTSTTTTGGGGGGGGGGEEEREEEEPE-----S----SC-SSSSSA-AA-AAAAAA-SGGSGGGGGGRYFRFFFVWF

AASAAAAAAATTTTTTTTTTGGNGGGGGGGFFFFFFFFFFSSSSSSSSSSETEEEQEEETPPPKPPDPPPLLLLLLLILLEEEEEEEEEALLLLNLLNLQVVVVIVVIVVKKKRRKKKKKYYYYYYYYYYKKKAKKKKK-K-KKKKKK--L-LLLLML--R-RRRRRR--AAAAAAAA--DLDDDYDD--LFLLLFLL--LLILFLLL--MMLMMMLM-------G----SASSSSSS--LILLLI-L--RYRRRYRR--ILLLLLLL--VVVVIVVI--DDDDDDDD--ED--DDE---LLPLLLL---FFFFFFF---FFFFFFF---FFFFFFF---ESQQESK---AATTAAT---VVLLLVL---YFYYHFFH--STGGSTGS--NNNDNNKN--FFFYFFRF--EEDDDEDDD-GGGGGGGGG-LLLLLLLL--VV--VVVV--

FFFFFFFLFFATQEQQAEEQKKKKKKKKRK---N----N-FYYYFFFYYFFFFFFFFFFFNMQREQNQRTQQQQQQQQQQTTTSTTTTTTSNQASSSSSSEDEEEEEEEEKKKKKKKKKKDDDDDDDDDDNAAAAANSATDEEDEEDDDEDEEEEEDEEEDSDDDDDDDDAASAEGAAAEIIIIIIIIIIDDDEEDDEEDSAATQASSSALLLLFILLLLPAVPPAPPPPLLLILLLLLLIVVIIVIIIILLLLLLLLLLWWWWWWWWWWLLILLLLLLLLILFLLLTFLVIIVVIVVVVVVVVVVVVVVIIILIIILLIGGGGGGGGGGFFYFYYFFFYLQELQQLLLQ

QEQQQQQEQQLLLLLLLLLLRRSRRRRRKRIIVIILIIIIKKKKKKKKKKGGGGGGGGGGPPSVTPSSTSPPPPPPPPPPFFFFFFFFFFRRRRRRRRRRAAAAAAAAAAAAAAAAAAAAVIVIIVIVIVMMMMVMMMMMASAAAAAAAAEEEDEEEEQEGGNNNGNGNN-L--------WWRWWWWWWWT---------KKKKFKFKKKDDNNNDNDNKYYYYYYYWYYLLLLLILVLLGSGGGSGSGGK---------F---------HHQGHHHHHQIILLIIIILLCCLMCCCCMLSSSSSSSCSSLLLLLLLLLLVVVVVVVVLVHHKHNHNHHKDDDDDDTDDDSSFFSSSSSF

EEEEEEKEDEYYYYYYYYYY-D---------R---------A---------P---------F---------L---------A---------Q---------R---------E---------T---------R---------G---------K---------K---------P---------Q---------S---------Q---------L---------S---------Q---------N---------K---------R---------------N---------F---------Y--LLCCLLLLLCFFIIFFFFYIMMMMIMMMMMKKKKKKKKKKVVIIVVVVVVDDDDDDDDDDEENEEEEEEEDEQQEQQEDQEEEEEEEEEEYYMYYYYYYYEAEEEEEEEELLMMLLILLMAQGAAAAAAATTIISTTTTIYYYYYYYYYYMMASMNNMMSFFFIFFFFFFAAAATFAAAAGGGGGGGGGGVVVVVIIVVVNEKENQQENEKKRKKKKKKKEDEEEEEDEEAMAAAAAAAAFYFHFYYYYYEEEEEEEVEDKRRNKKKKKKCCCCCCCCCCLVLLLLLVLLRLLLRLLLRLKKKKKKKKKKMTMMMLLIMM

LLILLLLLILNNNNNNNNNNAA-AAAAAAACCCCCCCCCCSDDDDDDDDDFFFFFFFYFFVVVKVVIVVVRKRKKKKKQKAAAAAAAAAAIIIIIIVIIIFHFYFRHFFYMLMLLLLMMLLLLLLLLLLLPPPKPPPPPTDEDDDDDDDDLLKLLLLLLLQSGSSQSSSSDDDDDNDDDDSSSHHSSSSKK--KK--K-KM--II--M-IEEDEDEEPDEEEEQGEEEEQMRRQR-RRRRKRRRRRRKRRTIVTQIITITNETDNQENQDRSGSSSSASSRKKKKKKKKKSSSTTSSSGTKRRKKRRKRKTATTTTTTTTYYYYYYYYYFSSSSSSSSSSDDDDDDDDDDNNNNNNNNNNYYYYYYYYYYLLLLLLLLLLLLLQLLLLWVLLMMLLLLMLLLLIILLLLIPPPFPPPPPP

NNNNNNNNNNDDDDDDDDDDYYYYYYYWYYPPSSPPQPPPLLMMLLLLLLKKSSKKKKKKRRRRRRRRRRNNGNNTNNNSWWFYWWWWWWFFFFFFFFFFDDDDDSDDDDYLAAAADLATGGGGGGGGGGAAAAGAAAGAIIIIIIVIIIPPPPPTPPPPSSSSASSSSSKKKKKKKQKVIIIIIIIIIIVFVVVVVFVVDDDNNDDDDDAAEEEEAATEAAEEEEASEEPPPPPPPPPPAEAAAAAEAAWWWWFWWWWW-------N--IIVVIVIIIVLLIILLLLLLAEEEEEAEEEHKHHHIHNHLHHHHHHHHHHVCYYCCCCCSRRRRRQRRRRAAMMAAAAAALLLLLLLLLLAARRPEAAPPHHHHHHHHNHIIMMIIIIVIAQAAAAAQAA

SSAASSSSSSQEQQQQQQQQRRRRRRRRRRDDDDDDDDDDVIVVIIEEIILLLL--LLM-ESTTSSTTSSYHYYQHHHHHKKKKKKKKKKTTTTTTTTTTSTTTTATTTTEKEEEEEEKEIIIILIIIILDDDDDDDDDDAAAAAAAPAALLLLLLLLLLYYYYYYTTYYVVVITVVVIVKKKKKKKKKKLRILMTMMMKKKTTKKKKKKKKKKKKKKKKEDEEDDEEDDIIIIVILLIINNNNNNNNNNSGTSDDEEKDKKKKKKKKKKQFQQSSQQTSQQQQQQQQQQQQQQMMQQKMQQTQQQEEQQMLMMLLMMLLQAEELAEEAAKGKKKKKKGKLLTTLLLLLLQQQQQMQQQQRETTRRKKER-E--QEEEEV

LLIVIIIILIQQKQQRQQQQYYYYYYYYYYEEDEENEEEEAALAVAVVANNSFRFNHFNNNDDDDDDDDDVPVVVVVVPVIIIIITIIIIIILLMLLRILGHMHMHMMHHGGGGGGGGGGVVIVIVIVVVPPPPPPPPPDAVAAAATAVAKKKKKKKKKK----A--A------F--F--NRNNQNNNRNRRRRSRRRRSVIILIILIIIIVIIIIILILNHNSASSAHS-F--------EEYHYHYYEHT-TTTKTTTT--YYYYYY-YDDSDNDNNDDTTATVTVVTTHHQHHHHHNHGGGGGGGGGGIIIVIIIIIIAAAAAAAAAAILIIIIFILIEEQEQEESEEKKKKKKKKKKRRRRRRRHRRLLLLLLLLLLRRKRKKKKRKVVIVVIIIVIIIIIIIIIIILLLLLLLLLLTEGGGGGGEG

RERRRR-RR-SSSSSSSSSSVMMTLVTVVSLLLILLLLLLIIIILIIITIMMMMAMMMMMVAAAAVMVVAFFFFFFAFFFS-SSSSSAAS-AA-A------LL-L------MM-M---------L------AA-N-----IVVIIIIIIIPAAPAIPPPPHYHHHHHHHHTA-TSSTGATVP-PPVPVVPAAAAAARAASIIIIIIVIIVANNNNANAANAAASAASAASL-LKLLILLILLLLLLL-LLDAESEQEDDEYHHYHHYYYYEDEDEEDEEDCCCCCCCCCCEGGGGGGGGGKRGKRKRKKRYYYYYYFYFYIVVKIITIITDDDDDDDDDDPPPPPPPPPPVTTYTTTVVTVVVFVVFVLFLLLLLLLLLL--Y-------GGGGGGGGGGLLLLLLLVVLLLLIVLILLIVVLVVVVVVATTTSTTSY-SLIILLLLLLLGGGGGGGGGGLLLTLLLLLLSNNNNSNSSNVVVLVILVVL

AVLAAAAIALEEEEEEEEEELIIMLMMIMMDDDGDDDEDDYSYYIYIYYYFFFFFFFFFFEEEEEEEEEE-PP----P---T---------S---------A---------R---------S---------K---------T---------G---------N---------K---------S---------L---------D---------S---------R---------S---------M---------F---------H---------F---------A---------L---------N---------R---------F---------S---------V---------F---------W---------I---------N---------Y---------D---------C---------A---------G---------P---------A---------N---------V---------F---------T---------G---------TS----S---EQ----Q---SS----S---DD----D----P----P---KK----K---MM----M---LL----L---FF----F---GG----G---ED----D---VV----V---NN----N---QR----R---PP----P---KK----K---VV----V---YY----Y---SS----S---LL----L---KG----K---LL----L---YY----Y---QR----Q---SA----A---SS----S---AA----A---PP----P--STTSTSTTST--K-------DEEEEEEEEEQRKTRQRRTRLLLMLLLLLLLLLILLLLILGGGGGGGGGGVIIIIIIIIISSSPSSSS-SSTTTTTTTTTKKKKKKKKKKPPPPPTPPPPTEEDETDEEEPP-PPPP-PPYYYFYYLYYYYYYLYYYYLYPPPPPPPPPPEEEEEEEEEEEDDEDEDDEDDRRRRRRRRRTATTTTVTTTEEEDEEEEEE---S----S----F----F----A----A-AVVVVAVVAAKKKKKKKKKKQRRENQNRERF---------GNNGGGGNGG----L---------E---------A---------Q---------A-----ENNDDERNDN----R-----GGGGGGGGGGAAATAAAAAGPPPPPPPPPPRRRRRRRRRRHNQYRHNQYNLLVLLLLVLLRRRRRRKRRR

RRRSRRNRRRCCCCCCCCCCLMMMLVVMMNPP-PPPPPPPDDDDDASDDDNNNGNNNNRNDDDDGDDNDDSNKNNSSSSNVVVVVVEVVVAAAAAAAAAATSTTSTNTTTVVVVVVVVVVKKKKKKKKKKGGGAGGGGGAQRKRHRRRRRAAAAAAAGGAQRRRRQQQQREEEEEEEEVEMILLILLL-LEEEEEEEDEE-QQRQ----R-LLLL----L-YYYY----Y-MLLL----L-LLLL----LACCCCCCATCTTTTTTCTTTMMTMLLLMMMSEEEESSSSEYYYYFYYFFYEE-EEEEEEEEEEEEDEEEESSSSSSSQANRNRRSRRRRRQNNNNNDQQNGGGGGGGGGGSNYNNNNSSNCCCCCCCCCCFFFFFFFFFFASAAAAVMMA-FY-F-----TTTTTSSTTTLLLLLLLLLLNNKNNKKNNNGGGGGGGSAGHHHHHRRHHHRKRRRRRRRRQSSQAQQ--QEEEEEEE--E

LLKKLKRKRLAMSAAAAAAAVVVVVVVVVVEEEEEEEEEECSCCCVVCVEKKNKKKKKKKGNGGGGGGGGVVVVVWVVVVRKRARRRRRKNDDDNDDDEDSSSSSSSSSANNNNNNNNNNFFFFFFFFFFIIIIIILILVEKEEEEEEEKIILVIIILIIKKKKKKSKSKSSSSSSSSSSSSSSSSSSSSHHYNHYYYYHNNDDNDDDDNLFFFFFFFFFNNNNNNNNNNAQAAAVVAVQYYYYYYYYYYYYYYYYYYYYDDHDDDDDNDAAAAAAAAQASSTSSSSSSSEEKKEKKKKESSSSSSSSSSLLLLLLLLLLAAGGASAGAA

VVVVILVVVVVVVVVVVVVQLLLLLLLLLLVVVVVVVVVVSSNSSSSATNVVVVVVVVVVF------F--KQRKKKKKRRQQQQQQQQQQLLLLLLMLLLKKRNNNNRKRFFFFFFFFFFVIIIIIIIIIV-LMMMMLLLMMVMMMMMMMPPPPPPPPPPAVVAAAAAVVLLLLLLLLLLTSSSSSSSSSDDENNNNDDEGGGGGGGGGGSSSSSSPSTSSSSTTTTSSSKQKKKKKKEKD--DDAAD--VVVVVIVVVVGDNNNNRGDNKEEQQQAKEEGGGGGGGGGGLLLMMMMLILHRWRRRRHR-SSSSIIISS-HSDHHHHHA-ACAAAAAACAYYYYYYYYYYDDDDDD-DGDTKKKKKKTKKEQEEEEEEEE

D--NDDD---E--EEEE---GLLGLLGLRLEEEEEEEEEEHHHHNHYHHHVIIIIIVIIIKMLKLMKYMMEEREEEEKKDNNNNTNNNNNEEEEEEEEEEIIIVIMIIINLLMLLLLMMLEEQEEEEMQEPVTASTPSTIYYYYYYYYYYSSSDSSSSSS-GGGEEGGGGLLLLLLLLLICCCCCCCCCCMTTTTTMTTTHVARRRHTTNSTTSTTSTTAIIVIIIIVVIAAAAAAAAAAFFLFYYFFLFFFFFFFFFFFFFFFFFFFFFSRRRSPSRRKGGAGNGGGAGDDEDDDDDEDFFFFFIFFFFYYYYYYYYYYIIIIIIIIII

PPPPPGGGPGQQQQQQQQQQGGGGGGGGGGPPPPPPPPPPCCCCCCCSCCVLLLLLLQLLHHHHHHHHHHAAAAAAAAAAVVVVIVVCVVFFFFFFFFFFVNNNNNNNVNYYYYYYYYYYDDDEEEEGDSHHHHHHHHHHP-PPPPPPPPRRRRRRRRRKEEEDEEEEEEPLPPLPPPPPRRRQRRQRRQVMLMMLLVVLVVVVTVVVVVSSSSSSSTSSSPPPPPPPSPDDDDDDNDDNSSSSSAAASAFFFFFFFFFFLLLLILLLLIIIIIIIIIIIRRRRRRRRRKVLVLVVVIVVIIIIIIIIIIEEEEEEEEEERR-RRRRRRRGGGGGGGGGGHSNNNTNNNNTTNTTNDSTDSTSSSSNTPN

---------V---------F---------Y---------K---------L---------Q---------V---------K---------Y---------I---------H---------A---------I---------I---------A---------H---------A---------A---------L---------L---------D---------K---------W---------A---------S---------L---------A---------SCCCCCCCCCCSSKKKSKSSSGGKKKGKGGGQEEEEEEQEQGDDDDDDDDGHVVVVVVVVTRRRKRRRRQRVLLLLVLVLVTTTTTTTTTTSAAAAAASASKKKKKKKKKKAAAAAAAAAAGGGGGGGGGGPPPPPPPPPPTTTTTTTTTTHHHHHHHHHHGGGGGGGGGGLLLLLLLLLLNNNNNNNNNNEEEEEEEEEESSSESSSSSSNQERQQQQQQPPPPPPPPPPGGGGGGG-GGFFLLFFFFYFVYYYYYYVYVNRRRKRKNRNLLLLLLLLLLAFLLLQLLLLDDDDDDDDDDKNTKTT-KTKIKIIII-IKINYNKNN-NNNRRKEKR-RRRDDDDDD-DDDFFFFFL-FFFVIVVVV-VIVVVVVVV-VVVTVSSST-TATGGGGGG-GGGMIIIII-IIMEESSEE-EEEVIIIVV-VIV

IIIHIVILVIPPPPPPPPPPNDDDDDDDDDSSSSSNSSNSPPPPPDPPDPIIIIIIIIIILLLLLLLLRLYYYYYYYFYFLLLLLLLLLLKKKKKKKKTKTTTTTTTTTTNNNNNNNNNN---TTST-T-EQEQKRQQQQQQQQQQQDQQGTGAAAAAAAMMMAAAAMAMSSSSSSSSNSEEEQEEDQEEQQQAQAQQQQLLLLLLLLLLASSSSSSSSCMMMMMMMMMMQQQTDDDDDDVVVVVVVVVVKRKRRRRRNRLLLLLILLLLLLLLLLLLILAAAAAAAAAADDDDDDDDDDWWWWWWWWWWRKKKKKKKKKRRRRQRRRRKRRRRRRRQRRKKKKKKKKKRSHPHHHHHHHCCCCCACAKAEEEEEEEEEEGGGGGGGGGGGGGGGGGGGGWWWWWWWWWWD---------KNDHHLHNHN---KKRK-R-

LLLLLLVLLLCCCCCCCICTVVVVVVVVVVGGGGGGGAGALLLLLLLLLLKKKKKKKRKRMMMMMMMMMMYYYHYYYYYYIIIIITTTITKKKKKKKKKSGAGGGAAAGAKKKKKKKEKEAAAAAAQAAARRRRRRRRRRVFLIFFFFIFDNDDDQQRNQSSSSSSSTSSLLLHLIIILITTTTT---T-LLLLL---I-KRKKR---K-VVVVV---V-HHHHHHRRHRLMLLMMMALDDDDDDDDDDDLLLLLLMLLLQQEQQQQQQQDDDDDDDDDEDDDDDDDDDDAAAAACCVALWWWWWWWWWWVVVVVVVVVVIIIIIIHHIHEEEEEEEEEERRRRRRRRRRK-KKKKKSRSTTTTTTTTTQ

SSDDDSDSSDTTMSTTTTTTVVVVVVVVVVNSQSSSSNNSILLLLLLLILEQQQQQQEEQKKKKKKKKKKPSPSSSSPPSNENNNENNNNGPAAAPAAGALLLLLLLLLLEEEEAEEEEAPLPPPPPPPPPPPPPPPPPPSDDDDDQDDDAAAQAAKAAASTTTTTTVSTKKKKKKKKKKLHLHNHHLLNKKKKKKKKTKVIMLIILMVIKKKKKKKKKKVFIFLFFVVFYIFIIIIFYIVVVVVVVVVVKKKKKKKKKKVVIIIIIIVIKNNNKNNNKKCCCCCCRCCCVVVAVVAVVVKEEEEEEEEELLLLLLLLLLREEEEEEERERRRRRRRRRREEEEEEEEEENGNGGGGNNG

IILIILVIVIILILIILILLNDNNNTDNNQLRFILIRLIRAATAATAAAAVSASTASAASGGGGGGGGGGKKKKKKKKKKSSTTSTSSTTPAPPPPAPPVKKKKKKKKKKITISIITIRT-----K---------G---------A---------N---------K---------G---------G---------L---------G---------Q---------K----RRRRRRRRRRGGGGGGGGGGYYYYYYYYYYYYYYYYYYYYKKKKKKKKKKKKKKKKKKKKPPPPPPPPPPSSKSSSSSSSEEEEEEEEEPAAAAAEAAAAKGAGAAGAGGMMMMMMMMMMMTTTMTTTTTNNNNNNNNNNAAIAVVAAARIIIIIIIIIVKAKKKKTKRRFWYFFFFFFFSASSSSASSAQQQQQEQQQQQQQQQQQQQRFFFFFFFFFF----M---------K---------L---------G---------K---------P---------E---------E---------M---------L---------P---------Y---------K---------E---------E---------Y---------R---------R---------G---------G---------A---------S---------I---------D---------E---------M---------G---------V---------M---------D---------T---------F---------K-----FFFFFFFIFFMMMMMMMAMMCCCCCCCSCCESEEEESEEEFFFFLFFFFFGGGGGGGGGGFFFFFFFFFF

LFFFFLLFLL-----A---------P---------W---------V---------S---------I---------D---------H---------P---------E---------T---------L---------V---------A---------S---------S---------I---------G---------M---------S---------K---------P---------E---------S---------A---------T---------V---------Y---------V---------N---------G---------M---------F----STTTTADTTS----D---------G---------M---------M---------D---------K---------T---------H-----VIILIILIIVPPPPPQPSPPVIIIIIIVIVPPPPPPPPPPKKHEEEEEEKLLLHLLLLLLQEEQQEDQQQRRRRRRRRRRKKKATKKAKKCCCTCQCCYCHDDNNNNNNNAAANGAANGAKKEKKKKKKKVVVVVIIVVVAAAIVAAVVA-RRKKRRKK--EEEEEEEE--GGGGGGGG--IILIIIII--RRDKWWKR-AAAVVAAVIASSSSSSSTGSEEEEEEEEEEAAAATAAEAA-HHHQHHHH-RRKTRRRKRRLMMLLMMLLLYYHFFYYFYYGGGGYGGGGGNNNHNNNHNNRKKKKKKKKREEEEEEEEEE

GGGGGGGGGGEEEEEEEEEEIIIIIIIIVITTTTTTTTTTVVVVVTVVVVASSSRSSSDSTTTTIITIIIMMMMMMMMMMLILCMLCLLLGGGGDDGDDDATTTAVTSVQFFWFFFFFFFRRHRRRRRRRVVRRVVRVVVEEEEEEEEEEKKEDKKDKKKVIIVIIVIIIRRRRRRRRRRLMIILLILLLSSSSSSSSLSGGGGGGGGGGIIIIIIIIIIEEQEEDNEEEFFFFFFFYIFRRRRRRRHRRSSSESSSSSSEEEEEEEEEECCCCACCCCCTTTTTTTTTTPPPPPPPPPPIIIIIVILVLEEEEEEEEEEIIIIIIIIIITSSSTTSTTTGGGGGGSGGGRRRRRRRRRRNNNNKKNKKK

EEEEEEQEEESSSSAAAAASAAAAAAAAAAMLMLMMMMMLFYFYFFYFFFDNDNEDEDDDVVVIFVIVVIFFFFFFFFAFPPPPPPPPPPGGGGGGGGGGGGGGGGGGGGSSSSSSSTSSSGSGSSHSSGPPPPDPDPPPEEEEEEEEEEVAAASAAAAAIILIVLILLIQQQPQQQQQQEQEQEEEEEEGGGGGGGGGGKKKKKKKKKKYFYSYYYYYYLLFLLFLFFLLLLLLLLLLLLLLLLLLLLLEEEEEEEEEEAVA-AAAAAANGN-NNNKNNVIFIIIIIIIAAAASASAAAFFFFFFFFFFIIIIVIIIVIYYYYYYYYYYYMYA-YEYYMVVVV-VVVVVLLLL-LLLLLL---------K---------T---------T---------S---------K---------K---------T---------I---------W---------D---------G---------Y---------D---------G---------S---------A---------F---------G---------K---------E---------F---------M---------D---------I---------K---------T---------T---------C---------S---------K---------V---------T---------VVVI-VVVVVNNNNNNNNNNDDGDDDD-DDFHHHYLLHHHIVVVVVVVVV

IIIIIIIRARRRRRRRRRARFFFFFFFFFLQQQQQQQQQQLLLIILLLILMTTTTTTTTTHHHNHHHHNHMLLLLLLALLGGGGGGGGGGCCCCCCCCCCRKRRKRRRRRPAAPAPASPSKKKKKKKKKKTIMIIIIIVVKMFMMMFMMMLIVIIIILILLLLLLLFLLLNNNNNNNNNNDEEEEDEDEDQGGQGQGQQQL-LL-LLLLLP-PP-PPPPPA-SA-ASAAAN-QT-SQSTSV-VV-VVVVVH-HY-HQHYHK-KK-KKKKKYYYYYYYYYYMLLLLLLILLFFFFFFFFFFKKKKKKKKKK----E-----GGGGGGGGGGYFFYFYFYYYIQIIQIIIVIYQQVQNQNNNDGGSGSGDSD

KRRRRRRRRR-DGADDTGGA-IIIILIIII-A--AA-----H--HH-----S--SS-----E--EE-----Q--QQ-----R--RR-----L--LL-----H--HH-----R--RR-----Y--YY-----E--EE-----A--AA-----Y--YY-----I--LL-----D--ED-----F--FF-----F--FF-----K--KK-----A--AA-----V--VV-----Y--YY-----K--KK-----D--DD-----D--DD-----D--DD-----S--SS-----N--NM-----L--LL-----Q--KQ-----K--KK-----M--MV-----I--VV-----Q--QR-----NKKNNTNKK-IIIILIIII-DDDDDDDDT-TIIIIIIVI-AAAAAAAAA-GGGGGGGNG-LLLLLLLLL-HHKHHRHQR-IILILLIILKKKKAKKKKKGGGGGGGGGGNNNNNNNNNNLLMVLLVLMVGGGGGPGGGGNNNNNNNNNNKKKTKKTKKTEEENEEQEEEVVVVVVMVVVFFFYFFYFFYTALAAAAAAASGGDGGGGGGRRRRRRRRRRKNKKTTKKKKIIILIILIILIIVAVVVIVV--IV--V-IVGGGGGGGGGGEEETEEKEEKRRRRRRRYRRSSSASSSTASEEEEDDEEEEQQQNRQAQQQPPRPPPPPPPIFFFFFFI-FHHHHHHHHHHQQQQQLQQQQRRRRRRRRRRAAAHAGHAAHLLLLALLLLLYYYYYYYYYYML--HH-L--FF--IF-F--DD--DD-D--AA--AA-A--HH--EH-H--QQ--QQ-Q--II--VV-V--

GGGGGGGGGGNHHHHHHHHHTTTTTTSTTSNNNNNQNNNNTMTTTMTTMTFSIFLFFFFFAAGGAAAAAAFHYYFFYFLYDEDDDEDDEDKKEEEKENKE-----I---------F---------F---------E---------K---------A---------E---------Y---------G---------V---------E---------A----AAAAAAAAAAAAAAAASAACLLLLLLLLLLRRRRRRRRRRLL--LL-LL-KLKKGLRGKQTTLTTTTTTTLLLLLLLVLLPPPPPPPPPPVVVVVVVVVVGGGGGGGGGGGGGGGGGGGESASSSASSSSRRRRKREQREAAARAAAAAAAAAAAAGAAGEKEEEREERERRRRRRRRRRAAAATAAAHELLLLLLLLLLAAAAAASAAAFHHHHHHHHHLILLMLLLLLVVVVVVIVVIIIIIIIIIII----T--T------Y--Y------L--L------R--R------N--S------S--S------K--K--SSSSSSSSSS--------M-HHDHWHHHHHKEENEETEEEAEMAAEAAAAEEEEEEDEEDRRKRRRRRRRNNNNNNNNNNGGGGGGAGGARCRRRCRRRR

MMMAAMMMMLEEEEEEEEEEGGGGGGGGGAETEEEEEETEMFMMMMDMMMNEENNNNNENRRRRRRRRRRHHHHHHHHHHAAAAASASAALLLLLLLLLLLLLLLLLLLLGEEEEAAGEEIIMKMIIIIAHHHHHHHHHHSEEEEEEEEELIAIIVVIIIQQHQKQQQMAQQQQQTNTQQKKKKKKKKKEILLLLIIILLSSSAASSSSSEQQQQEEEQHLLLLLMLLLLAAAAAAAAASFFFFFFFFFFHHHHHHDHHHSSASSSSSSSILLIIIIILITETLTPPPTTRRRRRRRRRRLLLLLLLLLLQQQQQQKSQQ

LMMMLMLLMLDSDNASSSNSEEEEAEEEEEEEEEEEEEEEIIIIIVIIIISSSSESEESDMHMHHHHHHHLLLLLLLLLLVVVVIVIIVVDDDDDDDDDDEEEEEEEEEETTTTTTTTTTQQQQRRRRRRPPPPPPPPPPYYYYYYWYYYKKKKKKKKKKGGGGNGGGGG----R---------V---------F-----KQKQEQEEQKSGSSAATAAAKKKKKQKKRKCACCCCCCYCAAAAAAAAAAVVVVVVVVVVTTTTVVVVVVRHHHRHRRHHEEEEEDEEEEVVVVCTCCVCCCCCCCCCCCVIVVVLVVIIDDDDEEEEDETTTTTTPPTTEEEEEEDDEDATGTTTTTTTAAAAAAAAAAFFFF------LLLL------DDDD------TPTPPPPPPPHHHHHHHHHHEEEEKEKKEKIVIIITIIIINGNNNNNNNNEEEEEEEEEEGGGGGGGGGGWWWWWWWWWWMMMMMMIIMM

DGGGDGGGGGRRRRRRRQRRFFFFFFFMFFVVVTTVVIVV--MM--MVM---TT--SSS---II--IVE-VVVVAVVVVVEEEEEEEEEEPPPPPPPPPPEEEEKEEEEEQDTDQQEDDDFFYYFFYYYFPPPSPPPPPPACCCACCCFCDDENDDDDDDSSCCSSSSSSAAAAAAAAAAYYYYYYYYYYKEKKKKKKKKIILIIIIIIIQKTTKKTKKKEEQQDDQQQEQQQQQQRQQQYYYYYYYRYYHHHHHHRHHHAAAAAAAAESPPPPPPPPPPITTTIITTTTLLLLLLLL-LILIIIIIIIIFYFFFFFFFFSSTSSSSSSS------A---------Y---------S---DGGGHSGGGGPPPPPPPPPPRKKKRRKKKKQEEEQEDEEQEEEEKEEEEERGMMWRLGGGNNNNNNNNNNSSSSSSFSSSNNNNNNNNNNQQQQAQEQQQSVSSSSSNSTLLLLLLLLLLGGGGGGGGGG

TTTTSTTTKTIIIIIIIIMIRRKRRRRRRRPPPPPPPPPPDDDDDDDDDDFFFFFFFFFFEEEEEEEEEEVVVIIVVVVVHHHHHHHHDHKKKKKKKKKKVVVTVVVVVVKAAAAAAAAADSSDDDNDEDRRKRRKKRRRKKKRRGKKKKQGGQQGGGGQFIIFFIIIIFLLLLLLLLLL--------R-QRRSSRRRRQEDDEEEDDDETTTMTTTTTTHHHPPHHHHHWWWWWWWWWWKKKEEKKKKKKKKKKKKKKKAAAAAAAAAARRKRRKKKRRIIVHTVVVIIHKKHYKKKKHSSSSSSSNSSSSSSSSSSSSASSSSSSSSANNNNNNNNNNKKKKK-KKKKLLMMM-MMMMSSSYSSSSSSLLLEEILLLLAAAAAAAAAA---------S---------R--A--A----ATTVVTTTAA

EEEEEEEEEDASSSQSSSSSASSSAASSSSQQQQQQQQAQPPPPPPPPPPLLLLLLLLLLVLLLVLLLLLQTSTHQSSTSKPPPKPPPPPRRRRRRRRRRPPPPPPPPPPLLVLIVLVLLWWWWWWWWWWAAASAAAAAAMAMAMTMMAARRRRRRRRRRTRTTTTTTTTIIVIIIIIIIGGGGGGGGGGTITITLIIIIIIIILIIIILITSTTTTTTTYYYYYHYHYYVLVIVVVVVVKVRRKKRRRRVIVVVIIVIITSSSTTSESSLVLVLLLLVLLVLVLLIVVVLLLLLLLLLL---V------RRRRRRRRRRYYYYYYYYYYHHHHHHQHHHERSREESSRSKKNKKKKKKKAAAAAAAAAAIIVVIVIVIVCCCCSCCCSCDDDDDDDDDD

VVVVVVVVVVSSSSSSSSSSTTTTTTTSTTLMLMILMLMLARIKAARRARRRRRRRRIRRVIVLIIVIVIEDSEEEKDEDAQAAAAAQAQGGGGGGGGGGWWWWWWWWWWSSSGSSSSSSCACACCAACAGGGGGGGGGGILLLLLLLLLFFFFFFFFFFLLL-LLLLLLSTSCASCTTTLLLLLLLLLLGGGGGGGGGGVIVIVVIIIIRRRKRRRRRRAAAVAAVSASLL-LLLLLLLQK-AQQKQKQAS-QAAQSASVVIVVIVVIVEEEEEEEEEESSSSSSSSSPA-A-AT----MMLMLLMMMMPHPPPPPQPHVTVVVVVTVSKAMAQNAVAVYHYYYYYYYYDTVQVTTSTTVVVVVVVVVVFLLLLLLLLLNKNNNNNKNKAVRVRAVAVVEPEPEEPPPP

PPPPPPPPPPAAAAAAAAAAIIIIIIVVMVLLLLFFFFLFYYYYYYYYYYYYYYYYYYYYIIVIVILLVLLLMLLLLLLLTTTTDDDDTDSSSSSRSRSSKKKKKKKKKKASAAVVVVAVLLLLLLLLLLSSSTSSSSSSDDDDEEDDDDKKKKKKVASALLLLLLLLLLDDDGDDDDDDLLLWLLLLLLDDDQEEEEDEIIIIIIIIIIGGTGAAAGAAKKKKKRKKKKMNLNNTTTLTAASAAAAASAEEEEEEEEENLLLLLLLLLLLLLLLLLLLLRRKRRRR-K-RRRRRRR-R-VVVVIII-V-HHHHHHA-H-FFFFFFF-F-EEEEEED-E-KKKKRRK-K-

CCCCVCVVCASSSSSSSSTSKKKKKKKKKKAAAAAAAAAAKKKKKAKKKKGGGGGGGGGG------N---------D---------K---AAGGASASGAGGGGWGGGGGQEDDDDDDDDEEEEEEEEEENQSSQQQQQEAAVVAAAAAAGGGGGGGGGGITIIIIIIVIAAAAAAAAAAKKKKKKKKKKTVPPTSTTTTQQQQQEQQKQVVVVTVVVVVWWWWWWWWWWDDDDDDDDDDPPPPPPPPPPAAAAAAAACAKKKKKKKKKRIIVVIIIIILHHHHHHHHHHKKKKKAKKKKAAGGAGAAAAFFLFFFPFFFVVVVVVVVVVGGGGGGGGRGGGGGGGGGGGDDDDEDDDDDRRKKRRRRRRIIIIKILLILTATTTTTSTTKKKKKKKKKKVVIVILILIILLLLLLLLLLLLLLMLLLLLGGGGGGGAGAPPAAPAPPAPTTTTTTSTTT

EQSQKQQLQQFFFLFFFFFFEEEEEEEEEEAEAAASVSVAQQTTQQHQHHPPPPPPPPPPIIIIIIVIIISSSSTSSSSSAAPPAAPAAAQKKKQKKKKKIIIIIIIIIIRRRRRRRRRRDDTTDDTDTTEEAAEEAETAGGGGGAGAGGEDDDDDDDDDLLLLLLLLLLIHLLIILIIIGA--GG-GGGPE--PD-DNDDD--DD-DDDGGGGGGGGGGRRRRRRRRRKSFYFFFFFFLSSSSSSSNSSSSGAAAAAAGQQHHQRHHHHNNNNN-N-NDDDDDD-D-DDNNNNN-N-NN--NN--N---DDDDD-D-DDEEEEDEEEEEFFFFFFFFFFPPPPPPPPPPKNKTKKKKKK

QVEVQVEVVVDDDDDDDDDD-----G----AAAAVASAAARRRRRRRRRREEEEEEEEEENNNNNNNNNNYHYHYHYYHHLLLILLLLLVLLLLMLLLLLSNNNNNNHNN-D-D-D--DDSDNDSDDNDDEEEEEEEEEEVVVAVVVVVLLLLILILVILETETETDDTTLVIIILIVIVFFFFFYFFFFIVIVIVIIVVRKKKKKKKKTYFYFYFYFFAAASAAAAAAANTNNNNNNNNATVTITTTTTHHHHHHHHHHISITITTTTSVSSSASSSNSSSSASSSSSSQQQEQQQQEQVVVVVVVVVVLTLLLVLLLTGGGGGGGGGGKKKKKKKKKKEEEDEEEVEEASAAAAAAASYFFFYFFFFISSSSSSSSASIIVLIIIITIEEEEEEEMED

GGGGGGGGGGPPPPPPPPPPIVIIVVVVAIFFFFFFFFFFVVVVVVVVVVDDDDDDEDDDLLLLLHLLLLNNNDNNNNNDPPPPPPPPPPEEEEEEEEEEFFFFFFFFFFIIMLVMMIMMTSSSSYYSSSPP--P--P--RRRRRRRRRR-P--P------H--H-----YHYYHYYYYYFFFFFFFFFFKKKRRKKKKKRRRRRRRRRRKKKEKKKKKEIILLIILILLVILLILLIFLHYYYYYYYYYKKKKKKKKKKFYFCICAFCCIVVVVVVVVVVVVVVVVVVVAAAAAAPAPAVAV-VVVAVVVVVVVVVVIVEEEEEEEEEELLLLLLLLMLKKKKKKKKKQDNNNDNNNNNPPPPPPPPPPDDDDDDDDDDQDDDDDDDEDMLMMLLLMMMKKQQKCCKKQGGGGGGGGGG

AAAAAAAAAAIILMMIILIMSSSSSSTSTSFFFFFFFFFFTTVVVTTVTVNNNNNKNNSNGGSNSGNSNNNNNNNKNNNNGAGGGGGGGGLLLLLILLLLDDNNNDNNNNQRMMMRRMRMVVVTVVVIVVVVMCCVVVVCHNNNNNNNNSLLLLLLILLVVVVVIVVVVVEEENEEEAEKVVIVVVIVII------P-P-TTRKKTTKTKFFFFFFFFKFAAAAAAKAKAPPPPPPPPPPIIIVIIIIIIFFFFFFFFFFTTTTTTDTVTHHHHHHHHHHFFFFFFFIFFEEEEEEEEEEHHHHHHHHMHYYLLLFFLFLKKKKKKKKKKPPPPPPPPPP

EEQEEEEEEENNNRNNNRNNFAFIFIVIIIEEDQDQEQQQDDDDDDDDDD---------YKDKKKKEKKKQKQKQEKKKKLLTLTLLLLL--A-G-------C-A-----FYFYFYYYYYRRRRKRRRRRLAAAAAAAAAGGGGAGGGGGVVAVAVVVSVYYYYYYYYYYSTSSSNSSSSDAEAENAAAACICVCA-VLLGGGGGGGDGGLLLVLLLVVVAIVVVVIVVITTTVTTTVVVDGDEDDGDDDEEEEEEEEEECACCCCAACCDEDDEDDDDDLLLLLLLLLVAAAAAAAAKAVIVVVVIVVVGGGGGGGGGGYYIYYYYYYYAAAAAAAAAA---G---GGG---L---LILGGGGGGGGGGHGHGHGGGFGGGGGGGGGGGKKKKKKKKKKPPPLPPPFLPKKKRKKKRKKIMIVIIMVVVKRKRKRRRRR

LLLLLLLMLLNNDNNNNNYNLLLLLLLLLLKMKKNKKKKKFFFFFFFFFFVVVVVVVVVVHKHHHHHHHHLLFLLLLLLLGGGGSGGGGGDDDDDDDDDDRVVVHVSMIVPPQQPPPQPPKKPKKKKKKRVVLVVVVVVVVVVVVVVVVVHHHHHHHHHHYYYYYYYFYFFFYYFFFFFFFFYYFFFYFY----W-W---EEEEEEEEEENNNNNNNNNNVVVVVVVLVLIIIIIIIIIIKKQQFKMQKSDDPPDDDPDPRRRKRRRRRRRRRRRRRKRKEEEEEEEEEENSTTSSSSSSIILLIIILILHHHHQHQHHEPPPPPPPPPPRQKAQRSQQQPPPPPPPPPAIIIIIVILILLLILILILLLGGGGGGGGGGHHHHHHHHHSMMLMMMMMMM

LHLLLHLLIHAAAAAAAAAANNNNKNNNNNRVRVIVVVIVKKKKKKKKKKPPPPPPPPPPAAAAAAAAAATASTTATTTA-----P---------N----GGGGGNGSGGSSSSSSSSSSEEEEEEEEEEKQKKKQKKKQSDSDDDDDDDIIIIIIILIIGGGGGGGGGG--A---------S---------S---------E---------A---------G---------L---------S---------N---------F---------N---------G---------I---------A---------L---------Q---------E---------Q---------R--------I--------DDDDEDDDDDRWRHRHHHRHPPPPPPPPPPRKRKKKKKKKLLLLLLLLLLTSGTTETTTSLLLLLLLLLLLALSAASSAADEDEEEEEEEDNDDDDDDDNRRRHRRHHARGGGGGGGGGGDDDDDDDDDDLLLLLLLLLL-------P---------L---------I---------T--YYYFYYYFYYRRRRRRRRRRRWRWWWWWWWLLLLLLLLLLCCCCCCCCCC

IIIVIIIVIYT---------L---------NEKDDDDKDNPPPPPPPPP-F---------Y--------YEEEEEEEEEESSGSSSSGSSRKK-RKQKKR--T----S----V----V----K----K----L----L----L----L----G----G----K----K----M----M----R----K----L----L----N----N----Q----Q----A----A----C----A----C----C----E----E----M----M----R----R----K----K----G----G----K----L----P----P--PPP-PPPPPPIII-IIIMIIIII-VLHILIKKR-KEKREKVIIIIIILIVLLLLLLLLLLILLLLGFLLIIIVTTTNATIVVIVVVVIVVIIIIIIIIILAASSSSSGSGIIVVVSVVVILLLLLLLLLLLVTIVVVTVLVLVVVVVVVVLLLVVVVLVLLLLLLLLLLLRRRRKRRRRRLLLIIIILILVVVVVVVVVVG-SGGGGSGGW-WWWWWWWWQQTQQQETQHKKKRKLLKLKVVVVVVVVVVTTPTTTTPTTNDDDDDDDDNDDSDDDDSDDEEEEEAEQEAAAAAAAAAAAIIVIIIIVIVIIIIIIIIIIAAVVVIIIIA

DDDGDDDDDDNQDNDNDHDD-R---------M---------I---------N---------V---------D---------T---------H---------D---------L---------L---------A---------F---------G---------V---------A---------F---------F---------K---------G---------V---------G--------DDDDDDDNDDAAAAGAAAAAIFFVLLFFLVGGGGGGEGAG--Q-QQ--QQ--E-AE--EE------L---------A---GGGGGGGGGGGGGGGGGGGGVLVIVVVVVV--P-PP--PP--L-LL--LLAPPPPPPPPPEQEEQQEEEESSSSASSSSSIYYIYYYFYYFFLFFFFFFFWWWWWWWWWW-------G---------P---------W---------L---------K--ILPILLLLPPMMMMMMMMTINNNNNKNNCCDEEEEEEDEELVILVVLLVVGSQSSSSSSSIIIIIIVVLLLLILLLLLLTAGGGGGGGGGKKKKKKKKKKDDEDEEDD--KKKKKKKK--GGGGGGGGGGWWWWWWWWWWLVVLVVVVIIFFFFFFFFFFKRRVRRQRRREEEEEEEEEERRRRGRRRRRNTQTVTTTTTFFFFFFFFFFIVLVIIIILLYYYYYYYYYYGGGGWGGGGG----K---------V---------R---------P---------H---------A---------K---------I---------L---------S---------I---------S---------L---------V---------L---------K---------K---------D---------E-----

IIIVT-IIIILLLII-ILILHHHSV-AAAHHHMHHHHHPHAAATASAAAAKKKVEVEKESAAAAAAAAAALIVLLLLLLLIVVVVVVIVVLLLLLLLLLLNNDNTNTNND----M-M-M-----I-I-I-----K-K-K-----P-P-P-LLLLLLLLFLIIIFRFIIIIIII-I-IIITVVVVVVVVVVAAERARRMAATYYYYYYYYYYYYYYYYYYYEEEEEEEEEELLLLLLLFLLEQQEQEEEEQIVVVVVVVVVIVVIVVVVVIQQQQQQQQQQVVVVVVVVVVRKRKKKKRKRPPAPPPPGPALVVIIIIIIVMMMVVVVMVMVVVVLAIVVVEEEDEDEEKEEAEEEEEDEELLLLLLLVLLQRLQQQQEQLIVITITIIIIGGG------GDDD------DMMMMVPVMMMEEEEEEEDEE

FFFFFFFFFFGGGGGGGGGGPPPPPIPPPPTLSLTSSTSTNNNNNNNNDNFFIFLIILIFHKKKKKKRKKKKKKKKKKKKFFFFFFFFFHAAAAAAAAAALFLLLLLRLLKKKKKKKKWKGGKGGKKGKGRRRLSRRRRRRRRRRRRRRRVIIIIIIIYVNNNNGNNGNNPPSPPPPPSPEEEEEEEEEKLLALLLLLLLNNNNNNDNNNTTMTTTTTMTSSGSSSGSGSKKEKEEEEEKDEQEREENEDIIIIIIIIIIKRKRKKKEKKKKKKKKKKKKGAPAPPPPPAKKKKKKKKKKIIIIIIAIIIYYYYYYYYYY--S-----S---N-----D-SSASSAASASAAAAAAAAAANNKNNGKSKNMMQMMQQMQM

PPPPPPPPPPTTTTTTTTTTAAAAAAAAAVIAASTVAAAAKKKKKKVKKKPPPPPPPPPPVATVVASIVV--AA--AAAA--EE--EEEE--LM--LMMM--LL--LLLL--KK--KKKK--TT--TSTT--CC--CCCC--AP--APPP--PP--KPPP--LF--LWLW--SS--SSSS--TT--TTTT--AA--AAAA--SP--SPPPAAAAAAAAAALLFLLLLLLLVVAAVVSAVAKKKTKKKKKKDNDDSNDNDDQQLLQKLIILQQQQQQQRQQIILIIIIVIIYYHYFYHHHYTIIITIIIIILLLLLLLLLLAAAAAAAAAALLLLLLLLLLPPPPPAPPPPDDEDDGEDDDQKKKQKKKKKIITVIVTAAIKQQQKQQQQQAAGGAAGGGGGGGGGGGGGGEEEEEEEEEELLLLLYLLLLRRRRRRRRRRTTTTTTTTTTAAAAAAAATAHHGNHHGGGNQQRRQQNRNQGAAAGAASMA

FFFFFFFFFFWWWWWWWWWWHEEEEEEEEERRRRRRRRRR--L-------PPPPPPPPPP--------E---------K---------P---------S---------L-VVVVVVIIVIAAAAAAAAAARKRRRRRRRRLLLLLLLLLLHHHHHHHGHHGGGGGGGGGG-STSSSSSSSTTTTTTVVTTNNNNN-NTNNDEDDDDDDDD-E---------K---------V---------K--------IVIIIIIIMIGGGGGGSSGSKKKKKKNNKTHHHHHRHTHHAAAAAAASAASSSFFSSSSS-----L----TTTTTTVVAAKKKKKKKKKKEEEEEESEEESSSSSSSSSSLLILLLLLLL-----L----RKRRRKRRRR-K---------H---------R--------AAATAARRARPPPPSPPPPPWWWWWWWWWWNNNNNNNNNNQLQHHMQLQQ

KKKKKKKRKKLVVLVVVVIVRRRRRRRRRKQSQQEQSQQQEQEEEEQEEEKKKKKKKKKKWWWWWWWWWWRR-RRRR-R-IV-IILV-L-LT-LVLT-L-GG-GGGG-G-NN-NNNN-N-VV-VVLV-V-RW-RRRR-R-VV-VVTV-T-NN-NNGN-G-SL-LIIL-L-RR-RRKR-K-WW-WWWW-W-LL-LILL-L-NN-NNNN-N-DK-DKKK-K-EE-EEEE-E-VV-VVVA-V-SS-DSTA-T-EE-EEEE-E-FF-FFFF-F-DD-DDDD-D-AAAAAAAAAAFFFFFFFFFFIIIVLIIVIFAAAAAAASAALLLLLLLLLL

EEEEEKEEEKPMMPMFPPPLPPPPPPPPPPSSSSSSSSSGAKVAAAAAAASVSSVQSSSQKKKKKKKKKKLIIIIIIIII--D--D---D--L--L---LRRRRRRRRRRPPPPPPPPPPVVIVVIVVVILLFLLLLLLFGVAAAFAGGAVVIVVVVVVVRRQRKQRRRQSSSSSSSSSSILIIIIIILIEQQQQQQEEQHRHHRRHDDRDDDEDDEDDDRNHRHHRRRHAGASGASAAALMILMMLLLMIIIIIVIIIVRKKRRRRKKRNNNNNNNSSNAAAAAAAAAAPPPPPPPPPPEAAAAAAEEEVVILVIVVVIQEEEEEEEEEQQQQQQQQQQLFLLFVILLVLLLLLLLLLE-----C----LLLLLLLLLLFFFLFTLFFF-------S---------T---------V---------I--VVVIVVVVVVVIVAVVAVVVLLLLLLLLLTAAAAAVAAAA

GYYGYYYGYYTTTTTTTQTT---I---I--QEEQEEEQEEGGGGKGGGGGTTTTTTTTTNEEEEEEEEEEEDEEEEEEEEIIILIIIIIIGAAAAAAAAADPPQPPPQPPLLLLQQLLQGNNNNNNNNNNGGGGGGGGGGRRRRRRRRRREEEEEEEEEKPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPAAPGGAPGGRRTRRRRRRRL-LL---L--A-AA---A--D-DD---D--P-PP---P--KKKRKKKRKKGGGGSGGGSSVVVVKIVVKKASDSSSSSSS-L--------IIIMIVIIIIQEEEHEEEEHAAAASAAASSD---------LLILLLLLLLAGAAGGGADG--------N-NNNNNDNNNKYYYYYYYYYYAPPPPPPPPPCCCCCCCCCCFNFFFFFFIFVVVVVTVVVVWWWWWWWWWWDRDDKRRDQKKKKKKEKKKKKRQNRRRSQREEEEPPPEPPAAAAAAAAAAWYYYYYYYYF------M---

MMMMMMMYMMMIMIIIIIMIRRRRRRRRRRVVVVSVVTVVTTTTTTTTTTQRQQQRQQQQYYYYYYYYYYRRRRRRRRRRAAAKAAAGAALLILLLLLLMHRHRRRRRHRAAAAAAAAAAGLGGGGGGGGEEEEDEEDEEIIIIIVILVINNNNSENNNNHQHHQQHHHHMMMMIMMMMMRRRRRRRRRRRRRRARRAKRVIVVVVVVVTQQQQQKQQQQKKKKKKRKKRILIIILVIIVLLLLLLLLLLIFIIIFIIIITTTTTTTTTTEAEDEDDDDDHHHHHHHHHHPPPPPPDPPDLLLLLLLLLLPTPSESTEPTQAQQQAQSPQEEEEDEEEEERRKRLRLLRLSSSSSSRSSSASAASSSSAS

------D---------G---------V---------P---LLLLLLLLLLSSSSSSSSSSIIIIIIIIVIALAALLLLAAHRHYRRRRHHKKPKKKKRKKGGGGAAGAGGIIVITTISIIL---------QQQQQQQQQQAAAVSAAAAADDDNDDDDDDIVLIFFFFLLVVVVVVVVVVGGQGSSGSAQAAAAAAAARA----D-----FYFFFFFFFF-H--HHHH--LLLLLLLLLLKRRRRRRRRR-Q--------TTTTTTTTTTSSTSSSSSSTFFFFFFFFFFEKDEKRKKEENSSNSSSSSSPPPPPPPPPPRRKRRRRRKKLQQLQQQQQQRRQRHRRRCSLALLLLLLLMFFFFWFFWFFSGTSIIKISSQRQNQQQQQQAAAAAAAAYTKKKKKKKKKKIIVILIIIVVSSSSSSSSSSQNEQNNNNDDVVAVAAAAAAVVIIVVVVVVSNSSKKNKSSSSNSASSASSEEEEEEEEEELLLLLLLMLL

AAATTTTTATTTTTTTTTTTEEEQQQQQEQRRRRRRRRRRRRRRRRRRRRGEGGGGGGEGLELLLLLLELLLLLLLLLLLKKKKKKVVKKQRQRRRRRRRRRRRRRIIRRDDDDDDDDDDNKKKKKKKEKYYYYYYYYYYSSSSSSSNSSTSTTTTVVTTTEEPPPPPEPTCTCCCCCCCAAAAVISAAWVVVVVVVVVVEEEEEEVVEEIIIIIIILIIPPPPPPPPPPCCCCCCCCCCYDYYYFYYDYPPPPPPPPPPAAAAAADDAAPPPPPPPPPPAAAAAAAAAAHHHHRHHHHHVTIIIITTTTPPPPPPPPPPII-AVVIVIVLLLLLLLMLL-I---------A---------L---------M--------AAAEEEAAAAATACCCCSTN---III----VVVVVVVVVVKDKSPPPPRPGGGGGGGGGGEEEEEEEEEEFFFFYFFFFFPPPPPPPPPPMMMMMMMMMKFFFFFFFFFF

VVVVVVVVVVTTSTTTTSTTVVIVLVVVVINSNNNNNNNNRRRRRRRRRRDDDDDDDDDDFFQFLLIFNQFFYFFFFFYYSSASSSSSAAKKKKKKKKKKLAALLLLLLL---------L---------T---------G---------E---------E---------T---------G---------I---------A---------G---------E---------E---------T---------LNNTNQNTDTTAAAAAAAAIADEDEDDEDDDNNNNNNNNNNKKKKKKKKKKAGGGGGGGGGYYYYYYYYYYGGEGGEGGEEYYNYYYYYNNIVDVIAVIDD---N------NNNNNINNNNSGTGSTGSTTWWWWWWWWWWLLLLLLLLLMLLLLLLLLLLGGGGGGGGGGVVVVVVVVVVLLLLLLLLILKKSKQQKQQQPPPGPPGPPPLLVLLVLLIVTTMTTTTTMQGGGGGGGGGGLLLLLLILLL

NN--------AAMAMMATAAGGGGGGGGGREEEYEEEEEEGGGGGGGGGAYYYYYYYYYYSSQQQQQQQQMMMMMMMMMMKKKKQKKRKKLLVTVVVVVVEEEEEEEEEEYYDYDDYFFY-DDDEDDDDDFFFFFFIFFFEEEEEEEEEECC--------KK--------EE--------RK--------SS--------TTVTVVTSSTEEEEEEEDDQLIIVLVIVVTIIIIITIIIIRTTTTTTTTTLLLLLLLILLDNDDDDDDDDNNNNNNKNNNTAAAAAAAAAVAKEKEVVVVHHKKKKHAKHDNNNNNNNNNRRRRRRRRRRLLVVVVLMMLEEEEEEEEEEKKQMQQQQQQ--YYYY-YY-PPPPPPPPPP

KKKKKKKKKKAAASAAASASQQHQHHHQQQ---H-----YGGGGGGGGGGAGGGGGGGGGFIIIIIIIII----R---------P---------F---------R---------G-----NSSSKSSSRSVVVVVVVVVV-GGGGGGG-GPPPPPPPPPPLLLLLLLSLLIIIIVIVIIITTTTRTTTTTTTTPTTNPTPPPPPPPPPPPPDEDNEDEEDVLVLVVVVVLFFFFFFFFFFKKKKKKKKKKMLMLMMMLML---E------VVVAVVVAVALTITIIITLTYHYYYFYYYYQQQQRQRQQQGGGGGGGGGGYYYYYYYYYYFFFFFFFFFFTTTTTTTTTTWWWWWWWWWWPPPSPPPTPSAAAAAAAASAMPPPPPPPMP

SSSSSSSSSSVVVVVVIIVVTITIITLLIIDLNLLNNNNELLLMILTTLIAAAAAAAAAATTTTTTTNTTNTNTTTQQTTGGGGGGGGGGVVVVVVVVVVLLLLLLLLLLVVVVVIVVVVLFLFFLIILFQQHKQQQEQQVVIVVIPPVVESESSEEEESLLLLLLAALLAAAAAAAALAGGGAGGGGGGVIIIIVVIIVTTTTTSTTTTIAIVVILIIVHEHEEHEEEEYYYYYYYYYYLLLLLLLVLL----L-------S-------RRRRRRRRRRSSSKKSPSSSL-L--L----F-F--F----V-V--V----TTTTTTTTTT-------A--GGGGGGGGGGGGGGGGGGGGAAAAAAAAAANNNNNNNNNNPPPPPPPPPPYFYFFLFFFFDDDDDDNDDDPPPPPPPPPPASASSASSSSTTTTTTTTTTGGGGGGGGGGVVVVVVLGVV-------L---------N---------L---------L---------A---------S---------S--

EEEEEEEEEEVVVVVVVVVVGGGGGGGGGG------Y---------D---------S---------F---------I---------T---------A---------K---------D---------F---PPPPPPPPPPEEEEEEKEEEASAAAAAAAA-KNK---K-KTLLLITIIILRRRRRRRRRRDDDDDDDDDDYYYYYYYYFYLLLLLLLLMLSNNNNTNNNNVVVVVVVVVVILVIVVVVVVHHHDQHHHHHQQQQQQQQQQVVVAVAVVVVLLLLLLLLIVVLLLMVMMMMLLLLLLLLLLLLLLLLLLILCCCCCCACCCLLLLFLLLLLAAAAAASAAAPPPPPSPPPPAAAAAAAAAARRRRRRRYRRLLLLILLLLLMMMEKMMMMIVMMMLVLMLLATTTTQTTGTQPPPEQEEEEVKKKKIKKKKAHAHAAAAAAGGGGNGGGNGLMMMMLMMMMKQEQQKQQQQTCCCHTTCITIVIVLIIILIHHHHHHHHHHVIIIIVIIIIKKQKRKKKRK-SSSS-SSDSAAPAAAAAAA

AAKRSRRAKKTSSSTSSTSSAAAAAAAARRVVFFIFFIFFLLVVLLILLLAATTETTESKNNNNNNNNNNAAAAAAAAAALLVVLVVLVVGANNGNNGNNEEEEEEEEEEAAAAAAAAAALLLLLIVLLLEEEEEEEEEEIIIIIVVIIIAAVAAAGAAAFFFFFFFFFFKKKKKKKKKKGGGGGGGGGGIIFFIFFIFILPDDSDDADDGKGGGGGAGGGGGGGGGGAGVVAVVIVVIILQLLLMILLLLLLLQLLQLLMMMMMRMMMMHHSHHHHHHHQTTTTTTTTTMMMMMMMLTMLLVVLVVLVVLLLLLILLLLQQQQQQQQQQSSSSSQSNSSTTIVTTTTQQFFFFFFFFFFYFIIYVVYVVKKTRKRRKRR

LLLLLLLLLLIIIIIIVVVVTIIIMMTTTTIFFVIVVIAVVIIVAVLVLLQ---QEQRQNI---LLLLLLI---IIMMMKD---DDDDDDI---IVLILL----SAAAAA----VIIIVMM---MMMMMMS---SSSSSNE---KKVEVVQ---SSQQQQA---AAAAAAM---LLMMMMY---YYYYYYIRRRRRKKKHEEEEEEEEEESSSSSSSSSSPPPPPPPPPPIVVVVIIIIIA-----GGGGRKKKKKRRKKKQQKKKEKKKLILLILLLLFFFFYFFFFFFEEEEEEEEEEEEEEDEDDDEPPPKPPPPPPAAAAAACACCDDEDNNDDADEEEEEEKKKKYYAYYYYYYYIMILIILLLLDDDDDDDDDDSTSSSSSASSRQQQQQRRRRGGGGGGGGGD

KKKKKKKNKKRRRRRRRRRRSSSSSSSSSETTTTTTTTTTNNNTKQSNNNYHYYYYYYYYWWWWWWWWRWTTTTTVTTTTSSSSSSSSSSDDDDDDDDDDLLLLLLLLLLFFFFFFFFFFRRRRLRRRRRPPPPPPPPPPVVVVVVVVVVLIIILLIIIIIALLLEELLLAAAAAAA-EAAEESAED-EETTTTTTT-TTKNNNKNN-NNPVVVPVA-VVPPPPPPK-PPYFFFYFY-FFPPPPPPP-PPGKNGGGG-GGKKKKKKK-KKRRRRRRR-RRPPPPPPP-PPVVVVVTT-VVLLLLLLF-LLHHHHHHHHHHNRRRRKKRKRPLLPPLLPPPNNNMNNGNNNSSSSSSSASSPPPPPPPPPPRRRSRSARRREFFFTFFFFFDEEEEEEEEE

A-SAGSAASALLLLLLLLLLSSSSSSSSSSFMWFLMFFWFKKKKKKKKKKDGGGGGGGGGPPPPPPPPPPCCCCCCCCCCDDDDDDDNDDYGGAYGGAGYVVVVVVIIVVLFCLLFLLFLTTHTTATLTTM--AL-AA-AI--II-II-IK--KK-RR-KPPPPPPPPPPSSSSSSTTSSEEEEEEEEEEVVVVVVVIVVMMMMMMMMMMLLLNLLLLLLLVIILIIIILEEEEEEGEEEQHQQQHQQQQPPPPPPPPPPEEAEEEEEEEGAGGGGGGGGVVVVVVVVVVFAFLFAFFFFFYFFFFFFFFAESEADEEEAATTAATAATAERRRRRRRRRHHHDHHHHHHNAAARAAAAR

SNNNSSSSNS--E-----E-FFFYFFFFFFLIIIIIILIITVVVVVVTVVLIIIIIIIIIVVVVVVVVVVWWWWWWWWWWEEEEDDEEEEM---IMMM-MAQQQKKKAQQVVVIVVVVVVSSSSSSSSSS-------T---------P---------F--IIIIVVVIIISAAAVVAAGADDDDEEDDDDEKKKKKKKKKVVVVVVVVVVIIIIIIIIIINNHHNNNNHNLLLLMMMLLFIVVVVIIIVFDEDDDDDDDDFLFFFFFFFFVVIVVVIVVVSSASSTSSSSVVVQVVVVVVSSSCASSSSSLLLLLLLLLRGGGGDDDGGGFMQLMLLLQLKKKKRRRKKKVVAAAPEAAAGGGGGGGGGGFFIVFFFMIFWWWWWWWWWWGGGGSSAGGGDDDDDDDDDDSTTTNNNNTTGGGGGGGGGGLLLLLLLLLL

D-DDNDD-DDG-GGGGG-GRNNQNNNNNHNEEDEEEDEEESPPPSPPPPSVIVIVVVIVVTSTSTTISVTIIIIILIVMIRRRRRRRRRKRRRQRRRRRRTSTSTTTSTTSDDDSDDDDSEEEEEEEENEIVIIIIIVIIAAAAAAAAAVL-L-LLL-ILG-N-GNN-NSE-D-EEE-EED-D-DDD-DDQ---------A-A-AAA-AA--------K---------Q---------P---------Q---------L---------T---------P---------K---------R---------T-P-V-PVV-AAP-P-PPP-PPE-R-ERK-RRG-G-GGG-GGI-P-IPP-PIQ-Q-QQQ-QQL-L-LLL-LLD-E-DDE-DES-S-HSS-PSF-F-FFF-FFI-I-III-IIR-R-RRR-RRT-T-TTT-TTK-K-KKK-KKV-V-VVV-VTM-R-MRR-RRA-A-ALA-VAL-L-LAL-GIV-V-VMV-LVF-F-FFF-FFS-S-SSS-SSG-G-GSG-GGS-S-SAS-SS

RKRRKRRKKGDDDEDDDDDDQAQQQQKQQQKKKKKKKKKEYYYYYYYYYYKKKKKKKKRKFFFFFLFFFFGGGGGGGAAGAAAAAAAATAM-MMMMM--FGGGGGGGGGGKAKKKKKAAKYYYYYYYYYYSSSSSSSAASGSGGRGGRRRKKKENEEKKKMTMMMMM-TMHHHHHHQ-HHIIIVIVV-RIQKQQQQQ-KQEEEEEDD-EEAAAAAAA-AAVVFVVAV-IVPPPPPPP-PPEDE-EEE-TEHHH-HHH-HHWWMWWWW-WWVVVVVVV-AVKKKKKTT-KKYYYYYYY-YYRRRRRQRRRRVVVILLIVVVDEDDRDDDEDPPPPPPPPPPIVVIIIIVVILLLLLLLLLLNNNNNNNNNGKQKKQKKQGQAAAAAAAAEASSSSSSSSSSRKKEKRRKKK

MMTLTMTMMTAAFGTAGAAARRRQRQRKKRYYYYYYYYYYFFFFFFFFFFSSSSSSSSSSIIIIIIIILIEEDEDEDEEDPPPPPPPPPPAVPAAAAAAPVIIIIIIIYI-VS-V-V--L-II-I-I--I-EE-E-E--ETTVTTSVTTILLLALALAALLLLLLLLLLL-----A----AAAAAAAAAA-------A---------I---------Y---------V---------E---------Y---------I---------A---------I---------A--PPPPPPPPPPWWWWWWWWWWSSSSSSSSSY-LL-L-L--LEEEEEEEEEEFLLLLLLLLLLLLLLLLLLLSSSSSSSSSSGGGGGGGGGGLLLLLLLLLLRRARSKEKRSEEEEEEEEEEVIIVIVILVI--N-N-N--NKKKKKKKKTKGGGGGGGGGGFFFFFFFFFFLALLLLLLLLYYYYYYYYYY