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Clinical features were those of a cicatricial pemphigoid, with prominent mucosal involvement leading to conjunctival and nasal scarring.
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The rapid progression under medical therapy prompted us to replace the thoracic aorta with an 8-mm polytetrafluoroethylene graft, using extracorporeal circulation and core cooling.
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Acute neutrophilic dermatosis induced by all-trans-retinoic acid treatment for acute promyelocytic leukemia.
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Medulloblastoma in a patient successfully treated for immature teratoma of the ovary.
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Pulmonary tuberculosis in a child receiving intensive chemotherapy for acute myeloblastic leukemia.
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The cornea showed diffuse edema and a stromal ring infiltrate (disciform in appearance).
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Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies.
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The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).
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Physicians in the United States, especially those who practice primary care, hematology/oncology, and infectious diseases, must be aware of the availability and use of metamizole in specific patient populations and its potential for harmful side effects.
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PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.
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Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis.
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They are usually localized reactions such as ecchymoses, erythematous plaques, and nodules.
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After therapy with parenteral amiodarone (2300 mg in 3 days) and other measures, signs of congestive heart failure disappeared; subsequently the patient developed jaundice, marked increase in serum transaminase levels and fall in prothrombin time, and histologic changes of severe centrilobular necrosis were observed in...
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Vicks VapoRub induces mucin secretion, decreases ciliary beat frequency, and increases tracheal mucus transport in the ferret trachea.
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Chemoradiation therapy used on pediatric oncology patients often causes dental developmental anomalies that affect future dental care.
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We present four cases of iatrogenic epidural spinal abscess directly caused by externally introduced catheters or probes.
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Reversible methotrexate-associated lymphoproliferative disorder resembling advanced gastric cancer in a patient with rheumatoid arthritis.
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He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.
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It most commonly occurs in association with hematologic malignancies and appears a few hours to a few days after initiation of specific chemotherapy, as the result from the release of intracellular components into the bloodstream due to abrupt malignant cell death.
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Accidental intrathecal injection of the wrong drug was suspected and a used ampule of tranexamic acid discovered in the trash can.
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Stupor from lamotrigine toxicity.
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Rituximab-CHOP induced interstitial pneumonitis in patients with disseminated extranodal marginal zone B cell lymphoma.
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Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).
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Aminophylline hypersensitivity apparently due to ethylenediamine.
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Ataxia caused by propafenone has been reported to the pharmaceutical companies and drug monitoring agencies, but has not been well described or emphasized in the medical literature.
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The Naranjo probability scale indicated a probable relationship between apnea and exposure to lamotrigine through breast-feeding in this infant.
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Multiple reports in the last decade have shown increased mortality and increased utilization of resources in patients who received catheterization of the right side of the heart.
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The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.
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However, recurrent staphylococcus aureus sepsis developed during CyA therapy.
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The mechanism remains unclear.
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One of the side-effects of intravitreal triamcinolone is the development of cataract, and it is known that cataract extraction can exacerbate macular degeneration.
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Well tolerated, midodrine appears to be a suitable and effective agent as it raises blood pressure significantly via its effect on peripheral alpha-adrenergic receptors.
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Spontaneous hemothorax following anticoagulation with low-molecular-weight heparin.
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Three patients were weaned from the VADs, and two survived.
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The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue and hypertension.
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The respiratory rate improved within 5 to 10 minutes of methylene blue administration and continued over a period of 2 hours.
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Power spectrum analysis of heart rate variability is useful in this instance because it magnifies the trace and detects even minor disturbances.
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CONCLUSIONS: Blood data did not always reflect marrow status.
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Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity.
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Medications having adverse effects on potassium metabolism were considered, and the patient's use of timolol maleate eyedrops was discontinued.
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Pulmonary edema as a delayed complication of ritodrine therapy.
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A 33-year-old man with advanced testicular cancer underwent high-dose chemotherapy combined with peripheral blood stem cell transplantation.
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His AFP was initially 9828 microg/L and rapidly dropped to 5597 microg/L in ten days after oral sorafenib treatment.
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All patients had typical radiological, magnetic resonance imaging or pathological changes of osteonecrosis involving the femoral heads, while two also had superimposed avascular necrosis involving the humeral heads.
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Fludarabine monophosphate, a purine analogue is used in the treatment of lymphoid malignancies.
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Apomorphine and diphasic dyskinesia.
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This is one of the few cases of drug-induced LAD in which the target antigen profile has been characterized, and the first in which the antigen has been shown to correspond to collagen VII.
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Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy.
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Acute aflatoxicosis: case report.
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We describe the development of methicillin-resistant Staphylococcus aureus osteomyelitis of the scaphoid in a 49-year-old man from an infection occurring around a catheter in the radial artery.
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Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C.
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An anovulatory patient was treated with human menopausal gonadotropin and human chorionic gonadotropin.
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He was admitted to the hospital for treatment after failing to improve on oral ciprofloxacin and inhaled tobramycin.
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Both patients with NMS had been treated with neuroleptics, including CYP2D6 substrates.
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Polymorphic ventricular tachycardia (PVT) is a form of ventricular tachycardia characterized by QRS complexes that seem to change direction during the tachycardia.
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Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.
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Hyperammonemia has been described as a complication of valproic acid therapy but may often be overlooked as a cause of lethargy in the postictal patient who presents to the emergency department.
1
Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.
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These evolutional changes in both proteinuria and glomerular histology suggest a close linkage between the M-CSF treatment and macrophage-related glomerular injury.
1
Secondary pancreatic involvement by diffuse large B-cell lymphoma presenting as acute pancreatitis: treatment and outcome.
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BACKGROUND: Bupropion, a novel antidepressant, has been reported to produce fewer adverse effects than the tricyclic antidepressants.
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An acquired form of sideroblastic anemia has been described in association with several drugs, especially anti-microbial agents.
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Suramin has demonstrated modest activity against prostate cancer and is being investigated in clinical trials.
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After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.
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Linezolid is relatively well tolerated and is not believed to be nephrotoxic.
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He had an extensive psychiatric history significant for schizophrenia and multiple past hospital admissions, starting at age 14 years.
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Nephrotic range proteinuria gradually regressed after stoppage of local injection of IFN-beta without glucocorticoid treatment.
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ADR induced by drug treatment can be a side effect of treatment with antipsychotic drugs and other drugs; however, there have been no reports of lamivudine-induced ADR in the English literature.
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With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.
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Use of somatostatin for complications occurring after liver transplantation.
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A case of severe acute hepatitis caused by cyproterone acetate in a 71 year old man with prostatic carcinoma is reported with a review of the literature on hepatic reactions to this drug.
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Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient.
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In these four patients, plasma carbamazepine concentrations after clarithromycin coadministration were approximately twice as high as those after its discontinuation.
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Successful long-term control with lamivudine against reactivated hepatitis B infection following intensive chemotherapy and autologous peripheral blood stem cell transplantation in non-Hodgkin's lymphoma: experience of 2 cases.
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There have been more than 20 observations of the appearance or aggravation of this granulomatosis with interferon alfa and more recently with the combination of interferon alfa plus ribavirin.
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A patient with torsade de pointes risk factors (female sex, advanced age, extreme bradycardia and renal failure) who developed the condition on the fourth day of 400 mg/day of oral moxifloxacin treatment is presented.
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Three of the 4 patients with hydrocephalus secondary to CNS tumor suffered secondary shunt complications during periods of severe neutropenia resulting from chemotherapy (6 weeks to 6 months after shunt insertion).
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Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.
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The bilateral ptosis markedly improved after 7 days of pyridoxine and pyridostigmine treatment and completely resolved after two weeks.
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Report of two cases, personal experience and review of the literature.
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In 3 of the 5 patients (60%) at 12 months after treatment, plasma cell dyscrasias could not be detected.
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A child with respiratory distress was found to have been given an antibiotic which was reconstituted with methadone.
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Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.
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Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.
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Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.
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Despite reduction in the dose of immunosuppression and localized radiotherapy, the tumor had rapidly progressed to involve the soft tissue of the right hand.
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OBJECTIVE: Omeprazole is one of the most widely prescribed gastric antisecretory drugs.
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Primary cutaneous coccidioidomycosis and subsequent drug eruption to itraconazole in a dog.
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Proteinuria resolved after the initiation of oral prednisolone therapy (1 mg/kg per day).
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A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment.
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Its etiology has still not yet been fully resolved.
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We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.
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Infant twins sustained severe circumoral and pharyngeal burns from a concentrated solution of benzalkonium (Zephiran) chloride prescribed for treatment of candidiasis.
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We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA).
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About three weeks into the therapy regimen, he complained of severe retrosternal chest oppression.
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The catheter was removed after 14 days because a local infection developed that resolved uneventfully with antibiotic therapy.
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The second patient, who developed cholestasis after receiving trimethoprim-sulfamethoxazole, had marked duct paucity in the liver biopsy.
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Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation.
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While doxorubicin was administered, the patient presented thoracic pain and breathing distress due to superior vena cava perforation by the central catheter and subsequent extravasation of the drug into the mediastinum.
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The patient received treatment with dexamethasone 0.2% eyedrops every 2 hours.
0