unprocessed
stringlengths 301
811
| processed
stringlengths 4
659
|
|---|---|
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Using reverse transcriptase combined with polymerase chain reactions in the analysis of a number of lipoma cell lines and primary lipomas , it appeared that LPP is frequently rearranged also in cases without a cytogenetically detectable involvement of 3q27 - q28 .
### Output Text: | Using reverse transcriptase combined with polymerase chain reactions in the analysis of a number of <span class="disease">lipoma</span> cell lines and <span class="disease">primary lipomas</span> , it appeared that LPP is frequently rearranged also in cases without a cytogenetically detectable involvement of 3q27 - q28 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Two alternative HMGIC / LPP hybrid transcripts have been detected ; the difference between them is mainly the presence of either two or three LIM domains in the predicted HMGI - C / LPP fusion proteins . .
### Output Text: | Two alternative HMGIC / LPP hybrid transcripts have been detected ; the difference between them is mainly the presence of either two or three LIM domains in the predicted HMGI - C / LPP fusion proteins . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript .
### Output Text: | Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human <span class="disease">Huntington disease</span> transcript . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The mutation underlying Huntington disease ( HD ) is CAG expansion in the first exon of the HD gene .
### Output Text: | The mutation underlying <span class="disease">Huntington disease</span> ( <span class="disease">HD</span> ) is CAG expansion in the first exon of the <span class="disease">HD</span> gene . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In order to investigate the role of CAG expansion in the pathogenesis of HD , we have produced transgenic mice containing the full length human HD cDNA with 44 CAG repeats .
### Output Text: | In order to investigate the role of CAG expansion in the pathogenesis of <span class="disease">HD</span> , we have produced transgenic mice containing the full length human <span class="disease">HD</span> cDNA with 44 CAG repeats . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: By 1 year , these mice have no behavioral abnormalities and morphometric analysis at 6 ( one animal ) and 9 ( two animals ) months age revealed no changes .
### Output Text: | By 1 year , these mice have no <span class="disease">behavioral abnormalities</span> and morphometric analysis at 6 ( one animal ) and 9 ( two animals ) months age revealed no changes . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Despite high levels of mRNA expression , there was no evidence of the HD gene product in any of these transgenic mice .
### Output Text: | Despite high levels of mRNA expression , there was no evidence of the <span class="disease">HD</span> gene product in any of these transgenic mice . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In vitro transfection studies indicated that the inclusion of 120 bp of the 5 UTR in the cDNA construct and the presence of a frameshift mutation at nucleotide 2349 prevented expression of the HD cDNA .
### Output Text: | In vitro transfection studies indicated that the inclusion of 120 bp of the 5 UTR in the cDNA construct and the presence of a frameshift mutation at nucleotide 2349 prevented expression of the <span class="disease">HD</span> cDNA . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These findings suggest that the pathogenesis of HD is not mediated through DNA - protein interaction and that presence of the RNA transcript with an expanded CAG repeat is insufficient to cause the disease .
### Output Text: | These findings suggest that the pathogenesis of <span class="disease">HD</span> is not mediated through DNA - protein interaction and that presence of the RNA transcript with an expanded CAG repeat is insufficient to cause the disease . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Rather , translation of the CAG is crucial for the pathogenesis of HD .
### Output Text: | Rather , translation of the CAG is crucial for the pathogenesis of <span class="disease">HD</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In contrast to that seen in humans , the CAG repeat in these mice was remarkably stable in 97 meioses .
### Output Text: | In contrast to that seen in humans , the CAG repeat in these mice was remarkably stable in 97 meioses . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: This suggests that genomic sequences may play a critical role in influencing repeat instability . .
### Output Text: | This suggests that genomic sequences may play a critical role in influencing repeat instability . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: FISH studies in a patient with sporadic aniridia and t ( 7 ; 11 ) ( q31 . 2 ; p13 ) .
### Output Text: | FISH studies in a patient with <span class="disease">sporadic aniridia</span> and t ( 7 ; 11 ) ( q31 . 2 ; p13 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: A 2 year old female presenting with bilateral sporadic aniridia was found to have an apparently balanced reciprocal translocation with a chromosome 11 breakpoint within band p13 .
### Output Text: | A 2 year old female presenting with <span class="disease">bilateral sporadic aniridia</span> was found to have an apparently balanced reciprocal translocation with a chromosome 11 breakpoint within band p13 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Fluorescence in situ hybridisation ( FISH ) studies with distal 11p13 specific cosmids showed that the chromosome 11 breakpoint lay between the aniridia ( PAX6 ) locus and a region approximately 100 kb distal to PAX6 defined by the cosmid FO2121 .
### Output Text: | Fluorescence in situ hybridisation ( FISH ) studies with distal 11p13 specific cosmids showed that the chromosome 11 breakpoint lay between the <span class="disease">aniridia</span> ( PAX6 ) locus and a region approximately 100 kb distal to PAX6 defined by the cosmid FO2121 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Although this patient did not have a detectable deletion within PAX6 , her aniridia may have resulted from a disruption of the distal chromatin domain containing either enhancers or regulators for PAX6 .
### Output Text: | Although this patient did not have a detectable deletion within PAX6 , her <span class="disease">aniridia</span> may have resulted from a disruption of the distal chromatin domain containing either enhancers or regulators for PAX6 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: This case may therefore be another example of aniridia caused by a position effect as recently described in two familial aniridia patients in which the phenotype cosegregated with chromosome abnormalities with 11p13 breakpoints . .
### Output Text: | This case may therefore be another example of <span class="disease">aniridia</span> caused by a position effect as recently described in two <span class="disease">familial aniridia</span> patients in which the phenotype cosegregated with <span class="disease">chromosome abnormalities</span> with 11p13 breakpoints . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Muscle expression of glucose - 6 - phosphate dehydrogenase deficiency in different variants .
### Output Text: | Muscle expression of <span class="disease">glucose - 6 - phosphate dehydrogenase deficiency</span> in different variants . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Muscle expression of G6PD deficiency has been investigated in Mediterranean , Seattle - like and A - variants .
### Output Text: | Muscle expression of <span class="disease">G6PD deficiency</span> has been investigated in Mediterranean , Seattle - like and A - variants . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: G6PD activity was detected in samples obtained from biopsies on the quadriceps muscle of seven males and one female .
### Output Text: | G6PD activity was detected in samples obtained from biopsies on the quadriceps muscle of seven males and one female . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The type of genetic variant was determined by molecular analysis of DNA , extracted from blood samples .
### Output Text: | The type of genetic variant was determined by molecular analysis of DNA , extracted from blood samples . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: All variants showed the enzyme defect in muscle .
### Output Text: | All variants showed the enzyme defect in muscle . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: A statistically significant relationship was found in the activity of G6PD between erythrocytes and muscle of the male subjects ( r = 0 . 968 ; p = 0 . 00008 ) .
### Output Text: | A statistically significant relationship was found in the activity of G6PD between erythrocytes and muscle of the male subjects ( r = 0 . 968 ; p = 0 . 00008 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The equation for the best fit line was Y = 0 .
### Output Text: | The equation for the best fit line was Y = 0 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 390X + 0 .
### Output Text: | 390X + 0 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 198 198 .
### Output Text: | 198 198 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The results suggest that , for a given variant , the extent of the enzyme defect in muscle may be determined , using this equation , from the G6PD activity of erythrocytes
### Output Text: | The results suggest that , for a given variant , the extent of the enzyme defect in muscle may be determined , using this equation , from the G6PD activity of erythrocytes |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Gene therapy for phenylketonuria .
### Output Text: | Gene therapy for <span class="disease">phenylketonuria</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Classical phenylketonuria ( PKU ) is an autosomal recessive disorder caused by a deficiency of hepatic phenylalanine hydroxylase ( PAH ) .
### Output Text: | Classical <span class="disease">phenylketonuria</span> ( <span class="disease">PKU</span> ) is an <span class="disease">autosomal recessive disorder</span> caused by a <span class="disease">deficiency of hepatic phenylalanine hydroxylase</span> ( PAH ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Limitations of the current dietary treatment for PKU have led to the development of potential treatments based on somatic gene transfer .
### Output Text: | Limitations of the current dietary treatment for <span class="disease">PKU</span> have led to the development of potential treatments based on somatic gene transfer . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Three different vector systems have been examined .
### Output Text: | Three different vector systems have been examined . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Vectors derived from a recombinant retrovirus or a DNA / protein complex can efficiently transduce the PAH cDNA into PAH - deficient hepatocytes in vitro , but the application of these vector systems is presently limited by their low transduction efficiency in vivo .
### Output Text: | Vectors derived from a recombinant retrovirus or a DNA / protein complex can efficiently transduce the PAH cDNA into <span class="disease">PAH - deficient</span> hepatocytes in vitro , but the application of these vector systems is presently limited by their low transduction efficiency in vivo . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In contrast , a vector derived from a recombinant adenovirus can restore 10 % - 80 % of normal hepatic PAH activity into PAH - deficient mice , which completely normalizes serum phenylalanine levels .
### Output Text: | In contrast , a vector derived from a recombinant adenovirus can restore 10 % - 80 % of normal hepatic PAH activity into <span class="disease">PAH - deficient</span> mice , which completely normalizes serum phenylalanine levels . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: This treatment is transient and cannot be effectively re - administered due to the presence of neutralizing antibodies directed against the recombinant adenoviral vector .
### Output Text: | This treatment is transient and cannot be effectively re - administered due to the presence of neutralizing antibodies directed against the recombinant adenoviral vector . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: However , these findings suggest that PKU can be completely corrected by somatic gene therapy , and provide some direction for the future development of adenoviral vectors . .
### Output Text: | However , these findings suggest that <span class="disease">PKU</span> can be completely corrected by somatic gene therapy , and provide some direction for the future development of adenoviral vectors . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Exon - intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit ( CHRNA4 ) .
### Output Text: | Exon - intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit ( CHRNA4 ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The human neuronal nicotinic acetylcholine receptor alpha 4 subunit gene ( CHRNA4 ) is located in the candidate region for three different phenotypes benign familial neonatal convulsions , autosomal dominant nocturnal frontal lobe epilepsy , and low - voltage EEG .
### Output Text: | The human neuronal nicotinic acetylcholine receptor alpha 4 subunit gene ( CHRNA4 ) is located in the candidate region for three different phenotypes <span class="disease">benign familial neonatal convulsions</span> , <span class="disease">autosomal dominant nocturnal frontal lobe epilepsy</span> , and low - voltage EEG . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Recently , a missense mutation in transmembrane domain 2 of CHRNA4 was found to be associated with autosomal dominant nocturnal frontal lobe epilepsy in one extended pedigree .
### Output Text: | Recently , a missense mutation in transmembrane domain 2 of CHRNA4 was found to be associated with <span class="disease">autosomal dominant nocturnal frontal lobe epilepsy</span> in one extended pedigree . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We have determined the genomic organization of CHRNA4 , which consists of six exons distributed over approximately 17 kb of genomic DNA .
### Output Text: | We have determined the genomic organization of CHRNA4 , which consists of six exons distributed over approximately 17 kb of genomic DNA . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The nucleotide sequence obtained from the genomic regions adjacent to the exon boundaries enabled us to develop a set of primer pairs for PCR amplification of the complete coding region .
### Output Text: | The nucleotide sequence obtained from the genomic regions adjacent to the exon boundaries enabled us to develop a set of primer pairs for PCR amplification of the complete coding region . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The sequence analysis provides the basis for a comprehensive mutation screening of CHRNA4 in the above - mentioned phenotypes and possibly in other types of idiopathic epilepsies . .
### Output Text: | The sequence analysis provides the basis for a comprehensive mutation screening of CHRNA4 in the above - mentioned phenotypes and possibly in other types of <span class="disease">idiopathic epilepsies</span> . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2 .
### Output Text: | Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: BRCA1 and BRCA2 are the two major identified causes of inherited breast cancer , with mutations in either gene conferring up to 80 - 90 % lifetime risk of breast cancer in carrier females .
### Output Text: | BRCA1 and BRCA2 are the two major identified causes of <span class="disease">inherited breast cancer</span> , with mutations in either gene conferring up to 80 - 90 % lifetime risk of <span class="disease">breast cancer</span> in carrier females . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Mutations in BRCA1 account for approximately 45 % of familial breast cancer and 90 % of inherited breast / ovarian cancer , whereas mutations in BRCA2 account for a comparable percentage of inherited breast cancer cases .
### Output Text: | Mutations in BRCA1 account for approximately 45 % of <span class="disease">familial breast cancer</span> and 90 % of <span class="disease">inherited breast / ovarian cancer</span> , whereas mutations in BRCA2 account for a comparable percentage of <span class="disease">inherited breast cancer</span> cases . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Over 85 distinct BRCA1 mutations and a growing list of BRCA2 mutations have been identified , with the majority resulting in protein truncation .
### Output Text: | Over 85 distinct BRCA1 mutations and a growing list of BRCA2 mutations have been identified , with the majority resulting in protein truncation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: A specific BRCA1 mutation , 185delAG , has a reported increased carrier frequency of approximately 0 .
### Output Text: | A specific BRCA1 mutation , 185delAG , has a reported increased carrier frequency of approximately 0 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 9 % in the Ashkenazi Jewish population , but is also found in rare non - Jewish patients with a different haplotype .
### Output Text: | 9 % in the Ashkenazi Jewish population , but is also found in rare non - Jewish patients with a different haplotype . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The 6174delT mutation in BRCA2 was recently identified as a frequent mutation in 8 out of 107 Ashkenazi Jewish women diagnosed with breast cancer by age 50 ( ref . 8 ) , as well as in three Ashkenazi male breast cancer patients .
### Output Text: | The 6174delT mutation in BRCA2 was recently identified as a frequent mutation in 8 out of 107 Ashkenazi Jewish women diagnosed with <span class="disease">breast cancer</span> by age 50 ( ref . 8 ) , as well as in three Ashkenazi <span class="disease">male breast cancer</span> patients . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We have conducted a large - scale population study to investigate the prevalence of specific BRCA1 and BRCA2 mutations in Ashkenazi Jewish individuals who were unselected for breast cancer .
### Output Text: | We have conducted a large - scale population study to investigate the prevalence of specific BRCA1 and BRCA2 mutations in Ashkenazi Jewish individuals who were unselected for <span class="disease">breast cancer</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: BRCA1 mutation screening on approximately 3 , 000 Ashkenazi Jewish samples determined a carrier frequency of 1 .
### Output Text: | BRCA1 mutation screening on approximately 3 , 000 Ashkenazi Jewish samples determined a carrier frequency of 1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 09 % for the 185delAG mutation and 0 .
### Output Text: | 09 % for the 185delAG mutation and 0 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 13 % for the 5382insC mutation .
### Output Text: | 13 % for the 5382insC mutation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: BRCA2 analysis on 3 , 085 individuals from the same population showed a carrier frequency of 1 .
### Output Text: | BRCA2 analysis on 3 , 085 individuals from the same population showed a carrier frequency of 1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 52 % for the 6174delT mutation .
### Output Text: | 52 % for the 6174delT mutation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: This expanded population - based study confirms that the BRCA1 185delAG mutation and the BRCA2 6174delT mutation constitute the two most frequent mutation alleles predisposing to hereditary breast cancer among the Ashkenazim , and suggests a relatively lower penetrance for the 6174delT mutation in BRCA2
### Output Text: | This expanded population - based study confirms that the BRCA1 185delAG mutation and the BRCA2 6174delT mutation constitute the two most frequent mutation alleles predisposing to <span class="disease">hereditary breast cancer</span> among the Ashkenazim , and suggests a relatively lower penetrance for the 6174delT mutation in BRCA2 |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Dual roles of ATM in the cellular response to radiation and in cell growth control .
### Output Text: | Dual roles of ATM in the cellular response to radiation and in cell growth control . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The gene mutated in ataxia - telangiectasia ( AT ) patients , denoted ATM , encodes a putative protein or lipid kinase .
### Output Text: | The gene mutated in <span class="disease">ataxia - telangiectasia</span> ( <span class="disease">AT</span> ) patients , denoted ATM , encodes a putative protein or lipid kinase . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: To elucidate the functions of ATM , we disrupted the mouse ATM gene through homologous recombination in mice .
### Output Text: | To elucidate the functions of ATM , we disrupted the mouse ATM gene through homologous recombination in mice . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Consistent with cellular defects of AT patients , the ATM - / - cells are hypersensitive to gamma - irradiation and defective in cell - cycle arrest following radiation , correlating with a defective up - regulation of p53 .
### Output Text: | Consistent with cellular defects of <span class="disease">AT</span> patients , the ATM - / - cells are hypersensitive to gamma - irradiation and defective in cell - cycle arrest following radiation , correlating with a defective up - regulation of p53 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In addition , ATM - / - mouse thymocytes are more resistant to apoptosis induced by gamma - irradiation than normal thymocytes .
### Output Text: | In addition , ATM - / - mouse thymocytes are more resistant to apoptosis induced by gamma - irradiation than normal thymocytes . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: ATM - / - fibroblasts are inefficient in G1 to S - phase progression following serum stimulation and senesce after only a few passages in culture .
### Output Text: | ATM - / - fibroblasts are inefficient in G1 to S - phase progression following serum stimulation and senesce after only a few passages in culture . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: They have an increased constitutive level of p21CP1 / WAF1 .
### Output Text: | They have an increased constitutive level of p21CP1 / WAF1 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The ATM protein is therefore critical both for cellular responses to ionizing radiation and for normal cell - cycle progression .
### Output Text: | The ATM protein is therefore critical both for cellular responses to ionizing radiation and for normal cell - cycle progression . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: ATM + / - fibroblasts and thymocytes showed intermediately defective responses to irradiation but no growth defect , suggesting that the increased cancer risk of AT heterozygotes could be attributable to poor checkpoint function . .
### Output Text: | ATM + / - fibroblasts and thymocytes showed intermediately defective responses to irradiation but no growth defect , suggesting that the increased <span class="disease">cancer</span> risk of <span class="disease">AT</span> heterozygotes could be attributable to poor checkpoint function . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Targeted disruption of ATM leads to growth retardation , chromosomal fragmentation during meiosis , immune defects , and thymic lymphoma .
### Output Text: | Targeted disruption of ATM leads to <span class="disease">growth retardation</span> , <span class="disease">chromosomal fragmentation during meiosis</span> , <span class="disease">immune defects</span> , and <span class="disease">thymic lymphoma</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: ATM , the gene mutated in the inherited human disease ataxia - telangiectasia , is a member of a family of kinases involved in DNA metabolism and cell - cycle checkpoint control .
### Output Text: | ATM , the gene mutated in the <span class="disease">inherited human disease</span> <span class="disease">ataxia - telangiectasia</span> , is a member of a family of kinases involved in DNA metabolism and cell - cycle checkpoint control . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: To help clarify the physiological roles of the ATM protein , we disrupted the ATM gene in mice through homologous recombination .
### Output Text: | To help clarify the physiological roles of the ATM protein , we disrupted the ATM gene in mice through homologous recombination . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Initial evaluation of the ATM knockout animals indicates that inactivation of the mouse ATM gene recreates much of the phenotype of ataxia - telangiectasia .
### Output Text: | Initial evaluation of the ATM knockout animals indicates that inactivation of the mouse ATM gene recreates much of the phenotype of <span class="disease">ataxia - telangiectasia</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The homozygous mutant ( ATM - / - ) mice are viable , growth - retarded , and infertile .
### Output Text: | The homozygous mutant ( ATM - / - ) mice are viable , growth - retarded , and infertile . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The infertility of ATM - / - mice results from meiotic failure .
### Output Text: | The <span class="disease">infertility</span> of ATM - / - mice results from meiotic failure . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Meiosis is arrested at the zygotene / pachytene stage of prophase I as a result of abnormal chromosomal synapsis and subsequent chromosome fragmentation .
### Output Text: | Meiosis is arrested at the zygotene / pachytene stage of prophase I as a result of abnormal chromosomal synapsis and subsequent chromosome fragmentation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Immune defects also are evident in ATM - / - mice , including reduced numbers of B220 + CD43 - pre - B cells , thymocytes , and peripheral T cells , as well as functional impairment of T - cell - dependent immune responses .
### Output Text: | <span class="disease">Immune defects</span> also are evident in ATM - / - mice , including reduced numbers of B220 + CD43 - pre - B cells , thymocytes , and peripheral T cells , as well as functional impairment of T - cell - dependent immune responses . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The cerebella of ATM - / - mice appear normal by histologic examination at 3 to 4 months and the mice have no gross behavioral abnormalities .
### Output Text: | The cerebella of ATM - / - mice appear normal by histologic examination at 3 to 4 months and the mice have no gross <span class="disease">behavioral abnormalities</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The majority of mutant mice rapidly develop thymic lymphomas and die before 4 months of age .
### Output Text: | The majority of mutant mice rapidly develop <span class="disease">thymic lymphomas</span> and die before 4 months of age . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These findings indicate that the ATM gene product plays an essential role in a diverse group of cellular processes , including meiosis , the normal growth of somatic tissues , immune development , and tumor suppression . .
### Output Text: | These findings indicate that the ATM gene product plays an essential role in a diverse group of cellular processes , including meiosis , the normal growth of somatic tissues , immune development , and <span class="disease">tumor</span> suppression . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Cloning and characterization of human very - long - chain acyl - CoA dehydrogenase cDNA , chromosomal assignment of the gene and identification in four patients of nine different mutations within the VLCAD gene .
### Output Text: | Cloning and characterization of human very - long - chain acyl - CoA dehydrogenase cDNA , chromosomal assignment of the gene and identification in four patients of nine different mutations within the VLCAD gene . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Very - long - chain acyl - CoA dehydrogenase ( VLCAD ) is one of four straight - chain acyl - CoA dehydrogenase ( ACD ) enzymes , which are all nuclear encoded mitochondrial flavoproteins catalyzing the initial step in fatty acid beta - oxidation .
### Output Text: | Very - long - chain acyl - CoA dehydrogenase ( VLCAD ) is one of four straight - chain acyl - CoA dehydrogenase ( ACD ) enzymes , which are all nuclear encoded mitochondrial flavoproteins catalyzing the initial step in fatty acid beta - oxidation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We have used the very fast , Rapid Amplification of cDNA Ends ( RACE ) based strategy to obtain the sequence of cDNAs encoding human VLCAD from placenta and fibroblasts .
### Output Text: | We have used the very fast , Rapid Amplification of cDNA Ends ( RACE ) based strategy to obtain the sequence of cDNAs encoding human VLCAD from placenta and fibroblasts . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Alignment of the predicted amino acid sequence of human VLCAD with those of the other human ACD enzymes revealed extensive sequence homology .
### Output Text: | Alignment of the predicted amino acid sequence of human VLCAD with those of the other human ACD enzymes revealed extensive sequence homology . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Moreover , human VLCAD and human acyl - CoA oxidase showed extensive sequence homology corroborating the notion that these genes are evolutionarily related .
### Output Text: | Moreover , human VLCAD and human acyl - CoA oxidase showed extensive sequence homology corroborating the notion that these genes are evolutionarily related . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Southern blot analysis of genomic DNA from hybrid cell lines was used to localize the VLCAD gene to human chromosome 17p11 .
### Output Text: | Southern blot analysis of genomic DNA from hybrid cell lines was used to localize the VLCAD gene to human chromosome 17p11 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 2 - p11 .
### Output Text: | 2 - p11 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: 13105 .
### Output Text: | 13105 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Using Northern and Western blot analysis to investigate the tissue specific distribution of VLCAD mRNA and protein in several human tissues we showed that VLCAD is most abundant in heart and skeletal muscle .
### Output Text: | Using Northern and Western blot analysis to investigate the tissue specific distribution of VLCAD mRNA and protein in several human tissues we showed that VLCAD is most abundant in heart and skeletal muscle . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: This agrees well with the fact that cardiac and muscle symptoms are characteristic for patients with VLCAD deficiency .
### Output Text: | This agrees well with the fact that cardiac and muscle symptoms are characteristic for patients with <span class="disease">VLCAD deficiency</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Northern blot analysis and sequencing of cloned PCR amplified VLCAD cDNA from four unrelated patients with VLCAD deficiency showed that VLCAD mRNA was undetectable in one patient and that the other three have mutations in both VLCAD alleles .
### Output Text: | Northern blot analysis and sequencing of cloned PCR amplified VLCAD cDNA from four unrelated patients with <span class="disease">VLCAD deficiency</span> showed that VLCAD mRNA was undetectable in one patient and that the other three have mutations in both VLCAD alleles . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Western blot analysis of patient fibroblasts showed that the identified mutations result in severely reduced amounts of VLCAD protein .
### Output Text: | Western blot analysis of patient fibroblasts showed that the identified mutations result in severely reduced amounts of VLCAD protein . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Molecular bases of combined subtotal deficiencies of C6 and C7 : their effects in combination with other C6 and C7 deficiencies .
### Output Text: | Molecular bases of <span class="disease">combined subtotal deficiencies of C6 and C7</span> : their effects in combination with other <span class="disease">C6 and C7 deficiencies</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Combined subtotal deficiency of C6 and C7 , in which both proteins are expressed at very low levels , has been observed in homozygous form in two families .
### Output Text: | <span class="disease">Combined subtotal deficiency of C6 and C7</span> , in which both proteins are expressed at very low levels , has been observed in homozygous form in two families . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: A defect at the 5 splice donor site of intron 15 of the C6 gene explains the low molecular weight of the C6 protein and is probably responsible for its low expressed concentration .
### Output Text: | A defect at the 5 splice donor site of intron 15 of the C6 gene explains the low molecular weight of the C6 protein and is probably responsible for its low expressed concentration . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The C7 defect is more enigmatic the protein is of normal molecular weight , low circulating concentration , and altered isoelectric point .
### Output Text: | The C7 defect is more enigmatic the protein is of normal molecular weight , low circulating concentration , and altered isoelectric point . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: An Arg > Ser codon substitution in exon 11 is the only molecular alteration within the mature C7 protein .
### Output Text: | An Arg > Ser codon substitution in exon 11 is the only molecular alteration within the mature C7 protein . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These defects are associated with a characteristic set of polymorphic DNA markers in the C6 / C7 region , forming a distinct haplotype .
### Output Text: | These defects are associated with a characteristic set of polymorphic DNA markers in the C6 / C7 region , forming a distinct haplotype . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The haplotype has been found in combination with a number of other haplotypes containing defective genes that lead either to C6 or C7 deficiency , but with different consequences .
### Output Text: | The haplotype has been found in combination with a number of other haplotypes containing defective genes that lead either to <span class="disease">C6 or C7 deficiency</span> , but with different consequences . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Where it is combined with a C6 - deficient gene , the serum C7 levels can be surprisingly high , possibly because there is no C6 generating C56 to consume the C7 .
### Output Text: | Where it is combined with a <span class="disease">C6 - deficient</span> gene , the serum C7 levels can be surprisingly high , possibly because there is no C6 generating C56 to consume the C7 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: In contrast , where the C7 genes are both defective ( but still partially functional ) , there may be a profound deficit of circulating C7 because there is ample C6 to produce C56 and consume the already small amount of C7 .
### Output Text: | In contrast , where the C7 genes are both defective ( but still partially functional ) , there may be a profound deficit of circulating C7 because there is ample C6 to produce C56 and consume the already small amount of C7 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Each molecular defect has also been found in isolation and has the expected effect . .
### Output Text: | Each molecular defect has also been found in isolation and has the expected effect . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Genetic bases of human complement C7 deficiency .
### Output Text: | Genetic bases of human <span class="disease">complement C7 deficiency</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Complement C7 deficiency ( C7D ) is associated frequently with recurrent bacterial infections , especially meningitis caused by Neisseria meningitidis .
### Output Text: | <span class="disease">Complement C7 deficiency</span> ( <span class="disease">C7D</span> ) is associated frequently with recurrent <span class="disease">bacterial infections</span> , especially <span class="disease">meningitis</span> caused by <span class="disease">Neisseria meningitidis</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We report in this work the molecular bases of C7D in two unrelated Japanese males .
### Output Text: | We report in this work the molecular bases of <span class="disease">C7D</span> in two unrelated Japanese males . |