Datasets:

bigbio

/

muchmore

like 0

Follow

BigScience Biomedical Datasets 112

[ { "id": "ZfuerRheumatologie.00590314.ger.abstr-passage-0", "type": "abstract", "text": [ "Studienziel : Untersuchung der analgetischen Wirksamkeit eines chemisch standardisierten Weidenrindenextraktes bei der Behandlung von Arthrose . Methoden : Weidenrindenextrakt , in einer Dosis entsprechend 240mg Salicin pro Tag , wurde in einer2-woechigen, doppelblinden randomisierten Studie , gegen Placebo geprueft . Hauptzielparameter war die Schmerzdimension des WOMAC-Arthrose-Indexes . Als Nebenzielparameter dienten die WOMAC-Teilscores zu Steifigkeit und Funktionsfaehigkeit , taegliche visuelle Analogskalen ( VAS ) zu Schmerz und Bewegungseinschraenkung und das abschliessende Gesamturteil sowohl des Patienten als auch des Arztes . Ergebnisse : 78 Patienten ( 39 Weidenrindenextrakt , 39 Placebo ) nahmen an der Studie teil . Ein statistisch signifikanter Unterschied zwischen Verum- und Placebogruppe wurde fuer die WOMAC-Schmerzdimension beobachtet ( d=6,5mm, 95% C.I. =0 , 2-12 , 7mm , p=0,047); waehrend der Behandlung verringerte sich der WOMAC-Schmerzscore gegenueber dem Ausgangswert um 14% in der Verumgruppe , verglichen mit einem Anstieg von 2% in der Placebogruppe . Dieses Ergebnis wurde durch die VAS der Patiententagebuecher bestaetigt . Die abschliessenden Gesamturteile zeigten eine deutliche Ueberlegenheit des Weidenrindenextraktes gegenueber Placebo ( Patientenurteil p=0,0002; , Arzturteil , p=0,0073). Schlussfolgerung : Weidenrindenextrakt zeigt eine moderate analgetische Wirksamkeit bei Arthrosepatienten ." ], "offsets": [ [ 0, 1442 ] ] } ]

[ { "id": "ZfuerRheumatologie.00590314.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 119, 129 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Arthrose" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022408" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Methoden" ], "offsets": [ [ 145, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "doppelblinden" ], "offsets": [ [ 257, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525065" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Placebo" ], "offsets": [ [ 301, 308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Schmerzdimension" ], "offsets": [ [ 347, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Schmerz" ], "offsets": [ [ 529, 536 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Bewegungseinschraenkung" ], "offsets": [ [ 541, 564 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035260" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 612, 621 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Arztes" ], "offsets": [ [ 635, 641 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 660, 669 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Placebo" ], "offsets": [ [ 700, 707 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Placebogruppe" ], "offsets": [ [ 800, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 924, 934 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Placebogruppe" ], "offsets": [ [ 1074, 1087 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Patiententagebuecher" ], "offsets": [ [ 1130, 1150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Placebo" ], "offsets": [ [ 1273, 1280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Patientenurteil" ], "offsets": [ [ 1283, 1298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Arzturteil" ], "offsets": [ [ 1311, 1321 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "type": "umlsterm", "text": [ "Arthrosepatienten" ], "offsets": [ [ 1423, 1440 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022408" } ] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t5", "type": "umlsterm", "text": [ "Arthrosepatienten" ], "offsets": [ [ 1423, 1440 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.00590314.ger.abstr-s1-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s1-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s2-r1-t1.2-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s2-r2-t1.2-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-r1-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-r2-t4.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-r3-t4.1-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-r4-t2.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-r5-t2.1-t1.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s4-r6-t3.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s5-r1-t1.1-t2.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s6-r1-t2.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s6-r2-t2.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r1-t4.1-t5.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r2-t4.1-t3.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r3-t1.1-t4.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r4-t5.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r5-t4.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r6-t3.1-t5.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r7-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r8-t3.1-t2.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r9-t3.1-t4.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r10-t3.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r11-t2.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590314.ger.abstr-s8-r12-t5.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.00590314.ger.abstr-s8-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.00590321.ger.abstr-passage-0", "type": "abstract", "text": [ "Trotz der zunehmenden internationalen Verbreitung der naturheilkundlichen und speziell der homoeopathischen Behandlung mangelt es bisher an kontrollierten Untersuchungen zu deren Wirksamkeit . In der vorliegenden Studie sollte die Frage beantwortet werden , ob eine Behandlung mit einer Kombination von Formica rufa D6 und Eigenblut-Injektion wirksamer ist als eine Placebo-Behandlung . 104 Patienten mit einer ankylosierenden Spondylitis in einer Rehabilitationsklinik wurden in die prospektive , randomisierte , placebokontrollierte und doppelblinde Studie aufgenommen und erhielten - zusaetzlich zu den balneophysikalischen Massnahmen - ueber vier Wochen entweder zweimal woechentlich 1 Ampulle Formica rufa D6 und 1 ml Eigenblut intramuskulaer oder 1,5 ml NaCl . Vor Beginn der Studie und am Ende der Behandlung wurden Beweglichkeitsausmass Atembreite und die Arzteinschaetzung , zum Gesundheitszustand erhoben . Zusaetzlich wurde der Gesundheitszustand aus Patientensicht mit einer deutschen Version der Arthritis Impact Measurement Scales zu Beginn und am Ende der Behandlung sowie vier zwoelf und vierundzwanzig Wochen , nach der Behandlung erfasst . Bei keinem der genannten Parameter fanden sich Unterschiede zwischen der Verum- und der Kontrollgruppe . Somit ergaben sich keine Hinweise auf eine Wirksamkeit der untersuchten Behandlungsform bei Patienten mit ankylosierender Spondylitis ." ], "offsets": [ [ 0, 1398 ] ] } ]

[ { "id": "ZfuerRheumatologie.00590321.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "naturheilkundlichen" ], "offsets": [ [ 54, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0349590" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 108, 118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 266, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Eigenblut-Injektion" ], "offsets": [ [ 323, 342 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Eigenblut-Injektion" ], "offsets": [ [ 323, 342 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Placebo-Behandlung" ], "offsets": [ [ 366, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Placebo-Behandlung" ], "offsets": [ [ 366, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 391, 400 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Spondylitis" ], "offsets": [ [ 427, 438 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038012" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "placebokontrollierte" ], "offsets": [ [ 514, 534 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "doppelblinde" ], "offsets": [ [ 539, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525065" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t5", "type": "umlsterm", "text": [ "Eigenblut" ], "offsets": [ [ 723, 732 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 805, 815 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Arzteinschaetzung" ], "offsets": [ [ 864, 881 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Gesundheitszustand" ], "offsets": [ [ 888, 906 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018759" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Gesundheitszustand" ], "offsets": [ [ 939, 957 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018759" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Patientensicht" ], "offsets": [ [ 962, 976 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 1009, 1018 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 1071, 1081 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 1137, 1147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1355, 1364 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Spondylitis" ], "offsets": [ [ 1385, 1396 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038012" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-r1-t2.1-t2.2", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-r2-t5.1-t4.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-r3-t1.1-t4.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-r4-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-r5-t5.1-t2.2", "type": "isa", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-r6-t2.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-r7-t1.1-t2.2", "type": "isa", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s2-r8-t2.2-t2.1", "type": "derivative_of", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r1-t4.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r2-t1.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r3-t2.1-t5.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r4-t5.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r5-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r6-t5.1-t5.2", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r7-t3.1-t2.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r8-t5.2-t2.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r9-t5.2-t5.1", "type": "derivative_of", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r10-t2.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s3-r11-t2.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s4-r1-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s4-r2-t3.1-t1.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r1-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r2-t3.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r3-t2.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r4-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r5-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r6-t1.1-t5.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r7-t2.1-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r8-t5.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r9-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r10-t1.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s5-r11-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590321.ger.abstr-s7-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.00590321.ger.abstr-s7-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.00590334.ger.abstr-passage-0", "type": "abstract", "text": [ "Eine 33-jaehrige Patientin , bei der vor zwei Jahren eine undifferenzierte Kollagenose mit sekundaerem Antiphospholipidsyndrom bei arteriellen Thrombosen , zwei Aborten und Myokarditis diagnostiziert worden war , hatte trotz effektiver Immunsuppression und Antikoagulation eine deutliche Progredienz der initial milde ausgepraegten praekapillaeren pulmonalen Hypertonie . Hinweise auf thrombembolische Ereignisse , kardiopulmonale oder andere systemische Erkrankungen als Ursache der pulmonalen Hypertonie fanden sich nicht . Nach Einleitung einer kontinuierlichen intravenoesen Iloprost-Therapie mit Dosissteigerung bis 4,5 ng/kg/min zeigte sich nach insgesamt fuenfzehnmonatiger Therapie sowohl eine verbesserte Belastbarkeit im Gehstreckentest ueber sechs Minuten ( von 210 auf 315 m ) als auch eine Reduktion des pulmonalvaskulaeren Widerstandes ( von 1710 auf 1111 dynxsxcm-5) und des pulmonalarteriellen Mitteldrucks ( von 64 auf 54 mmHg ) . Durch den partiellen Erfolg der konservativen Therapie konnte die Indikation fuer eine kombinierte Herz-Lungentransplantation zunaechst relativiert werden ." ], "offsets": [ [ 0, 1104 ] ] } ]

[ { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Thrombosen" ], "offsets": [ [ 143, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040053" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Aborten" ], "offsets": [ [ 161, 168 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000786" }, { "db_name": "UMLS", "db_id": "C0040364" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Myokarditis" ], "offsets": [ [ 173, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027059" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Immunsuppression" ], "offsets": [ [ 236, 252 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021079" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Hypertonie" ], "offsets": [ [ 359, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "pulmonalen Hypertonie" ], "offsets": [ [ 348, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020542" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Hypertonie" ], "offsets": [ [ 495, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020538" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "pulmonalen Hypertonie" ], "offsets": [ [ 484, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020542" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 681, 689 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Belastbarkeit" ], "offsets": [ [ 714, 727 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085086" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Mitteldrucks" ], "offsets": [ [ 910, 922 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 994, 1002 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Herz-Lungentransplantation" ], "offsets": [ [ 1047, 1073 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018787" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Herz-Lungentransplantation" ], "offsets": [ [ 1047, 1073 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024109" } ] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Herz-Lungentransplantation" ], "offsets": [ [ 1047, 1073 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r1-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r2-t4.1-t2.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r3-t2.2-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r4-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r5-t5.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r6-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r7-t2.2-t6.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r8-t5.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r9-t2.2-t3.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r10-t4.1-t5.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r11-t5.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r12-t1.1-t3.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r13-t5.1-t1.1", "type": "co-occurs_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r14-t1.1-t2.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r15-t1.1-t6.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r16-t2.2-t5.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r17-t2.2-t2.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r18-t1.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r19-t4.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r20-t1.1-t5.1", "type": "co-occurs_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r21-t1.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r22-t4.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r23-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r24-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r25-t1.1-t5.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r26-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s1-r27-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s2-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s2-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s3-r1-t3.1-t1.2", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s3-r3-t3.1-t1.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s4-r2-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s4-r3-t1.2-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590334.ger.abstr-s4-r4-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.00590334.ger.abstr-s4-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.00590343.ger.abstr-passage-0", "type": "abstract", "text": [ "Insuffizienzfrakturen werden als Kontinuitaetstrennungen nicht-tumoroes erkrankten Knochens ( z.B. bei Osteoporose , Rheumatoider Arthritis oder nach Radiatio ) bei normaler Belastung definiert . Zwei Faelle dieser Frakturen am Os ileum und Os sacrum werden exemplarisch vorgestellt . Risikofaktoren klinisches Bild , Diagnostik und Therapie , werden geschildert ." ], "offsets": [ [ 0, 364 ] ] } ]

[ { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Insuffizienzfrakturen" ], "offsets": [ [ 0, 21 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016658" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Knochens" ], "offsets": [ [ 83, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Osteoporose" ], "offsets": [ [ 103, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 130, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Belastung" ], "offsets": [ [ 174, 183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015264" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Rheumatoider Arthritis" ], "offsets": [ [ 117, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Frakturen" ], "offsets": [ [ 215, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016658" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Os sacrum" ], "offsets": [ [ 241, 250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036037" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Risikofaktoren" ], "offsets": [ [ 285, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035648" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Diagnostik" ], "offsets": [ [ 318, 328 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" } ] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 333, 341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r1-t5.1-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r2-t1.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r3-t4.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r4-t4.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r5-t1.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r6-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r7-t5.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r8-t2.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r9-t1.1-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r10-t6.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r11-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r12-t6.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r13-t2.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r14-t5.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r15-t4.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r16-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r17-t1.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r18-t5.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r19-t6.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r20-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r21-t1.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r22-t3.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s1-r23-t3.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s2-r1-t1.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s2-r2-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s3-r1-t2.1-t1.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s3-r2-t1.1-t3.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.00590343.ger.abstr-s3-r3-t2.1-t3.1", "type": "precedes", "arg1_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.00590343.ger.abstr-s3-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059i021.ger.abstr-passage-0", "type": "abstract", "text": [ "Die inflammationsmediierte Osteopenie ( IMO ) ist ein Tiermodell fuer die durch chronische Entzuendung ausgeloeste Osteopenie . Pathogenetisch spielen eine Abnahme der Hormonform von Vitamin D ( Calcitriol ) und erhoehte Spiegel von Zytokinen eine Rolle . Kennzeichnend ist eine Verminderung der Knochenneubildung und Osteoblastenaktivitaet . Durch Behandlung der Tiere mit 1,25-Dihydroxy-Vitamin D ( Calcitriol ) laesst sich im Tiermodell die Knochenstoffwechselstoerung verhindern ." ], "offsets": [ [ 0, 484 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Osteopenie" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029453" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Tiermodell" ], "offsets": [ [ 54, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Entzuendung" ], "offsets": [ [ 91, 102 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021368" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Osteopenie" ], "offsets": [ [ 115, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029453" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Hormonform" ], "offsets": [ [ 168, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019932" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 183, 190 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Calcitriol" ], "offsets": [ [ 195, 205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006674" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 248, 253 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Vitamin D" ], "offsets": [ [ 183, 192 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042866" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Knochenneubildung" ], "offsets": [ [ 296, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Knochenneubildung" ], "offsets": [ [ 296, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Osteoblastenaktivitaet" ], "offsets": [ [ 318, 340 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029418" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 349, 359 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Tiere" ], "offsets": [ [ 364, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Calcitriol" ], "offsets": [ [ 401, 411 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006674" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Tiermodell" ], "offsets": [ [ 429, 439 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "Knochenstoffwechselstoerung" ], "offsets": [ [ 444, 471 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t6", "type": "umlsterm", "text": [ "Knochenstoffwechselstoerung" ], "offsets": [ [ 444, 471 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025519" }, { "db_name": "UMLS", "db_id": "C0025520" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r1-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r2-t4.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r3-t3.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r4-t3.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r5-t1.1-t3.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r6-t3.1-t4.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r7-t4.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r8-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r9-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r10-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r11-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r12-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r13-t4.1-t3.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r14-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s1-r15-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r1-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r2-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r3-t1.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r4-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r5-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r6-t2.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r7-t5.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r8-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r9-t5.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r10-t5.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r11-t3.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s2-r12-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-r1-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-r2-t3.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-r3-t1.1-t3.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-r4-t3.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-r5-t1.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-r6-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s3-r7-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r1-t6.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t6", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r2-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r3-t1.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r4-t4.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r5-t1.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r6-t6.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t6", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r7-t5.1-t2.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r8-t5.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r9-t3.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r10-t3.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r11-t6.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t6", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r12-t5.1-t4.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r13-t5.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-r14-t5.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059i021.ger.abstr-s4-t6", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059i028.ger.abstr-passage-0", "type": "abstract", "text": [ "Aktive Vitamin D-Metabolite sind nicht nur entscheidend am Knochenmetabolismus beteiligt , sondern erfuellen darueber hinaus wichtige immunmodulatorische Funktionen im Rahmen von entzuendlichen Prozessen . Ziel unserer Studie war es , den Effekt einer Kurzzeittherapie mit 1-Hydroxycholecalciferol auf entzuendliche Aktivitaet und Knochenmetabolismus bei Patienten mit rheumatoider Arthritis ( RA ) zu evaluieren ." ], "offsets": [ [ 0, 414 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 7, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Kurzzeittherapie" ], "offsets": [ [ 252, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Kurzzeittherapie" ], "offsets": [ [ 252, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 355, 364 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 382, 391 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "rheumatoider Arthritis" ], "offsets": [ [ 369, 391 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-r2-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-r4-t5.1-t2.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-r5-t5.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-r6-t2.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-r7-t4.1-t2.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-r8-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059i028.ger.abstr-s2-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-passage-0", "type": "abstract", "text": [ "Glukokortikoide sind an der Regulation zahlreicher physiologischer Prozesse beteiligt . Die meisten ihrer Wirkungen werden vom Glukokortikoidrezeptor ( GR ) durch Aktivierung und Repression von Genexpression vermittelt . Waehrend die Aktivierung eine Bindung des Rezeptors and DNA erfordert , erfolgt die Repression in den meisten Faellen durch Protein-Protein-Wechselwirkung mit anderen Transkriptionsfaktoren . Zur Analyse des molekularen Mechanismus des GR wurden mittels gene targeting \" Maeuse \" mit einer Punktmutation in einer der Dimerisierungsdomaenen des Rezeptors erzeugt , welche den Verlust der DNA-Bindung zur Folge hatte . Diese GRdim-Maeuse ueberleben bis ins erwachsene Alter und erlauben sie die Analyse der Wirkungsweise des GR in physiologischen Prozessen . Insbesondere stellt sich heraus , dass die Stresserythropoese die DNA-bindungsabhaengige Funktion des GR benoetigt , waehrend die antitumorigene Wirkung des GR in der Haut durch Protein-Protein-Wechselwirkung mit dem Transkriptionsfaktor AP-1 vermittelt wird . Des Weiteren zeigt sich , dass die immunsuppressive und anti-inflammatorische Wirkung des GR weitgehend unabhaengig von dessen DNA-Bindung ist . Dies deutet daraufhin , dass GRdim-Maeuse in der Zukunft moeglicherweise zur Identifizierung steroidaler anti-inflammatorischer Substanzen mit geringeren Nebenwirkungen verwendet werden koennen ." ], "offsets": [ [ 0, 1379 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "physiologischer Prozesse" ], "offsets": [ [ 51, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031845" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Genexpression" ], "offsets": [ [ 194, 207 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017262" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Genexpression" ], "offsets": [ [ 194, 207 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "DNA" ], "offsets": [ [ 277, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012854" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Protein-Protein-Wechselwirkung" ], "offsets": [ [ 345, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Protein-Protein-Wechselwirkung" ], "offsets": [ [ 345, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Transkriptionsfaktoren" ], "offsets": [ [ 388, 410 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040648" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Analyse" ], "offsets": [ [ 417, 424 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "gene" ], "offsets": [ [ 475, 479 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Maeuse" ], "offsets": [ [ 492, 498 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025914" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Punktmutation" ], "offsets": [ [ 511, 524 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162735" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "erwachsene" ], "offsets": [ [ 676, 686 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001675" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Analyse" ], "offsets": [ [ 714, 721 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "physiologischen Prozessen" ], "offsets": [ [ 750, 775 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031845" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Haut" ], "offsets": [ [ 945, 949 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Protein-Protein-Wechselwirkung" ], "offsets": [ [ 956, 986 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Protein-Protein-Wechselwirkung" ], "offsets": [ [ 956, 986 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Transkriptionsfaktor AP-1" ], "offsets": [ [ 995, 1020 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085828" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s1-r1-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s1-r2-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s2-r1-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r1-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r3-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r4-t1.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r5-t4.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r6-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r7-t4.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r8-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r9-t4.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r10-t2.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r11-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s3-r12-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-r1-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-r2-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-r3-t4.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-r4-t1.1-t3.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s4-r5-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s5-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r1-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r2-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r3-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r4-t4.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r5-t4.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r6-t2.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r7-t1.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r8-t3.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r9-t2.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r10-t4.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r11-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-r12-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059i0i1.ger.abstr-s6-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-passage-0", "type": "abstract", "text": [ "Glukokortikoide sind an zahlreichen Prozessen in Geweben von Saeugetieren beteiligt . Sie kontrollieren Vorgaenge des Energiestoffwechsels , der Differenzierung , des Wachstums , des Zelltods und der Entzuendungshemmung ." ], "offsets": [ [ 0, 221 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Geweben" ], "offsets": [ [ 49, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Saeugetieren" ], "offsets": [ [ 61, 73 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024660" } ] }, { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Energiestoffwechsels" ], "offsets": [ [ 118, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025519" }, { "db_name": "UMLS", "db_id": "C0025520" } ] }, { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Wachstums" ], "offsets": [ [ 167, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s1-r1-t2.1-t3.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s1-r2-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s1-r3-t1.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.0059i0i6.ger.abstr-s2-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-passage-0", "type": "abstract", "text": [ "Interaktionen des Endokriniums , vor allem der Hypothalamus-Hypophyse-Nebennierenrinden-Achse und dem Immunsystem sind gut bekannt . Nur wenige Publikationen befassen sich allerdings mit den komplexen Einfluessen der Zytokine auf die Wirksamkeit der Glukokortikoide ( GK ) im Gewebe . Osteoblastenkulturen sind ein etabliertes Modell , um Interaktionen von GK und Zytokinen im Knochen zu studieren . Wir untersuchten deshalb zwei Zelllinien des humanen Osteosarkoms ( Saos-2 und MC-63) mit unterschiedlichen Differenzierungsgrad und unterschiedlicher konstitutiver IL-6-Produktion ( 3,4 +/- 0,3 ( SEM ) und 3309 +/- 578 pg/106 Zellen ) . Wir bestimmten die Dichte des Glukokortikoidrezeptors ( GR ) und seine Affinitaet in Abhaengigkeit unterschiedlicher IL-6-Mengen. Inkubationen von IL-6 ueber 20 h in zunehmenden Konzentrationen bis maximal 2000 pg/ml ergaben eine signifikante Zunahme der Bindungsstellen fuer den GR in beiden Zelllinien . Weiter konnte IL-6 den Hemmeffekt von Dexamethason ( 1 µmol/l) auf den GR aufheben . In MG-63-Zellinien, die eine hoehere Konzentration des GR verursachen , fuehrte eine Abnahme von IL-6 mittels eines spezifischen IL-6-Antikoerpers ( 100 ng/ml ) zu einer signifikanten Abnahme des GR . In den Saos-2-Zellen dagegen , welche eine niedrigere Konzentration des GR verursachen , erhoehte eine 40-stuendige Inkubation mit humanem IL-1 sowohl die IL-6- als auch die GR-Konzentration . Die gleichzeitige Behandlung mit dem IL-6-Antikoerper hob diesen Effekt wieder voellig auf . Nach unseren Ergebnissen besitzt IL-6 deshalb eine positive autokrin-modulierende Wirkung auf die Dichte des GR in humanen Osteoblasten ." ], "offsets": [ [ 0, 1653 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Immunsystem" ], "offsets": [ [ 102, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Publikationen" ], "offsets": [ [ 144, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Zytokine" ], "offsets": [ [ 217, 225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079189" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 250, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Gewebe" ], "offsets": [ [ 276, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Osteoblastenkulturen" ], "offsets": [ [ 285, 305 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029418" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Osteoblastenkulturen" ], "offsets": [ [ 285, 305 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010453" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Knochen" ], "offsets": [ [ 377, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 627, 633 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "IL-6" ], "offsets": [ [ 785, 789 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021760" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Konzentrationen" ], "offsets": [ [ 816, 831 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "IL-6" ], "offsets": [ [ 958, 962 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021760" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Dexamethason" ], "offsets": [ [ 982, 994 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011777" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Konzentration" ], "offsets": [ [ 1066, 1079 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "IL-6" ], "offsets": [ [ 1126, 1130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021760" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Konzentration" ], "offsets": [ [ 1284, 1297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "IL-1" ], "offsets": [ [ 1369, 1373 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021755" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 1441, 1451 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "IL-6" ], "offsets": [ [ 1549, 1553 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021760" } ] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "Osteoblasten" ], "offsets": [ [ 1639, 1651 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029418" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-r1-t4.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-r2-t3.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-r3-t4.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-r4-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-r5-t2.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s2-r6-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-r1-t3.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-r2-t1.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-r3-t3.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-r4-t1.1-t3.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s5-r1-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s5-r2-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s6-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s6-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-r1-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-r2-t1.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii103.ger.abstr-s10-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-passage-0", "type": "abstract", "text": [ "In frueheren Studien an Ratten wurde gezeigt , dass eine Dysfunktion der Hypothalamus-Hypophysen-Nebennieren ( HHN ) -Achse vor allen Dingen im Bereich des Hypothalamus lokalisiert ist ( genetisch determinierte inadaequate Sekretion von corticotropin-releasing-hormone ) . Dieser Defekt trug entscheidend zur Entwicklung einer Modell-Arthritis in diesen Tiermodellen bei . Beim Menschen stellt sich diese Situation allerdings anders dar : hier scheint der Defekt vor allen Dingen im Bereich der Nebenniere lokalisiert zu sein , wodurch es zu einer inadaequat niedrigen Kortisolproduktion bei chronisch entzuendlichen Erkrankungen in Relation zum systemischen Entzuendungsausmass kommt . Neben Kortisol ist auch ein anderes adrenales Steroid , das Dehydroepiandrosteron ( DHEA ) , drastisch erniedrigt . Die Ursache fuer die Stoerung der adrenalen Steroidproduktion bei rheumatoider Arthritis und anderen chronisch entzuendlichen Erkrankungen ist zur Zeit nicht bekannt . Da DHEA sowohl den Tumor-Nekrose-Faktor Alpha ( TNF ) als auch Interleukin IL ) ( -6 in vitro und in vivo hemmen kann , hat dieses adrenale Steroidhormon ebenso wie Kortisol wahrscheinlich eine antiinflammatorische Bedeutung . Die Wirkung des DHEA ist dabei durch eine Hemmung des nukleaeren Faktors NFB vermittelt . Des weiteren kann DHEA in peripheren Zellen wie beispielsweise Makrophagen zu antiinflammatorisch wirksamen Geschlechtshormonen wie Testosteron umgewandelt werden . Bei Patienten mit chronisch entzuendlichen Erkrankungen ist gerade DHEA deutlich erniedrigt , was durch eine zusaetzliche Glukokortikoidtherapie noch verstaerkt wird . Dieser Ueberlick demonstriert , warum gerade die Produktion von DHEA bei chronisch entzuendlichen Erkrankungen erniedrigt ist . Die Bedeutung der DHEA-Verarmung wird am Beispiel der Osteoporose demonstriert . Es wird dargestellt , weshalb die parallele Therapie mit Glukokortikoiden plus DHEA eine interessante Therapieoption bei chronisch entzuendlichen Erkrankungen darstellt ." ], "offsets": [ [ 0, 2000 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Ratten" ], "offsets": [ [ 24, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034693" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Hypothalamus" ], "offsets": [ [ 156, 168 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020663" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Sekretion" ], "offsets": [ [ 223, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036536" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Modell-Arthritis" ], "offsets": [ [ 327, 343 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Tiermodellen" ], "offsets": [ [ 354, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Menschen" ], "offsets": [ [ 378, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Nebenniere" ], "offsets": [ [ 495, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Entzuendungsausmass" ], "offsets": [ [ 659, 678 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021368" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Kortisol" ], "offsets": [ [ 693, 701 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020268" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Steroid" ], "offsets": [ [ 733, 740 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Dehydroepiandrosteron" ], "offsets": [ [ 747, 768 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011185" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Steroidproduktion" ], "offsets": [ [ 847, 864 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 882, 891 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Zeit" ], "offsets": [ [ 950, 954 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "rheumatoider Arthritis" ], "offsets": [ [ 869, 891 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Tumor-Nekrose-Faktor" ], "offsets": [ [ 990, 1010 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Tumor-Nekrose-Faktor" ], "offsets": [ [ 990, 1010 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Interleukin" ], "offsets": [ [ 1034, 1045 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021764" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Steroidhormon" ], "offsets": [ [ 1111, 1124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "type": "umlsterm", "text": [ "Steroidhormon" ], "offsets": [ [ 1111, 1124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019932" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "type": "umlsterm", "text": [ "Kortisol" ], "offsets": [ [ 1136, 1144 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020268" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t7", "type": "umlsterm", "text": [ "in vitro" ], "offsets": [ [ 1056, 1064 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021135" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 1325, 1331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Makrophagen" ], "offsets": [ [ 1351, 1362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024432" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Geschlechtshormonen" ], "offsets": [ [ 1396, 1415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036884" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "type": "umlsterm", "text": [ "Testosteron" ], "offsets": [ [ 1420, 1431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039601" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1457, 1466 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Osteoporose" ], "offsets": [ [ 1803, 1814 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 1874, 1882 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "type": "umlsterm", "text": [ "Therapieoption" ], "offsets": [ [ 1932, 1946 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s1-r1-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s1-r2-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s1-r3-t2.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s2-r1-t1.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s2-r2-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s3-r1-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s3-r2-t1.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-r3-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-r4-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-r5-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s4-r6-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s5-r1-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s5-r2-t1.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r1-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r2-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r3-t1.1-t6.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r4-t6.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r5-t2.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r6-t4.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r7-t1.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r8-t5.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r9-t6.1-t1.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r10-t5.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r11-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r12-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r13-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r14-t5.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r15-t3.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r16-t6.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r17-t6.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r18-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r19-t3.1-t1.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r20-t4.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r21-t2.1-t6.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r22-t4.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r23-t5.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r24-t6.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r25-t6.1-t2.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r26-t4.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r27-t2.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r28-t1.1-t2.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r29-t5.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r30-t3.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r31-t6.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s6-r32-t3.1-t2.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r2-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r3-t4.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r4-t1.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r5-t4.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r6-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r7-t3.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r8-t4.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r9-t3.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-r10-t2.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii108.ger.abstr-s8-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Nebennieren vereinen in engem Kontakt wesentliche Komponenten des autonomen Nervensystems und der Hypothalamus-Hypophysen-Nebennieren ( HHN ) -Achse . Aus morphologischen Analysen wie Immunhistochemie , In-situ-Hybridisierung , der neuen Technik der Laser-Capture-Mikrodissektion und der Elektronenmikroskopie wurden gezeigt , dass die chromaffinen Zellen des Nebennierenmarks und die Steroid-produzierenden Zellen der Nebennierenrinde eng verwoben sind . In In-vitro-Studien wurde eine Vielzahl verschiedener vom Nebennierenmark sezernierter Faktoren identifiziert , die die adrenokortikale Funktion beeinflussen . Eine isolierte , aus dem Gewebeverband herausgeloeste Nebennierenrindenzelle , die nicht mehr durch die Innervation oder durch interzellulaere Kommunikation mit chromaffinen Zellen , den Blutgefaessen oder Immunzellen beeinflusst wird , verliert ihre normale Kapazitaet , Glukokortikoide zu produzieren und somit adaequat auf stressbedingte homoeostatische Veraenderungen zu reagieren . Andererseits produzieren adrenokortikale Zellen in Kokultur mit chromaffinen Zellen die zehnfache Menge an Glukokortikoiden wie die selbe Anzahl isolierter Rindenzellen . Gleichzeitig wird in diesen Zellen die in isolierten Zellen reduzierte mRNA-Expression von Cytochrom-P450-Enzymen und StAR hoch reguliert . Dass die beidseitige Abhaengigkeit von sympathomadrenalem System und HHN-Achse auf der Ebene der Nebenniere fuer die physiologische Funktion in vivo wesentlich ist , wurde an transgenen Tiermodellen mit Ueberexpression oder Deletion von Genen der Katecholaminbiosynthese oder einer veraenderten Funktion von Komponenten der HHN-Achse gezeigt . Desweiteren beschrieben wir einen neuen nichtzytokinvermittelten Mechanismus , der immun-endokrinen Interaktion der auf direktem Zell-Zellkontakt zwischen Lymphozyten und Nebennierenzellen beruht . Veraenderungen in der interzellulaeren Kommunikation , der lokalen Produktion von Neuropeptiden , Wachstumsfaktoren und Zytokinen so wie die aberrante oder ektope Expression von Rezeptoren auf Nebennierenzellen koennen zu Veraenderungen im Nebennierenwachstum und zur Tumorbildung fuehren . Darueber hinaus zeigen neuere Daten , dass die immun-endokrine Regulation der Kortisol- und DHEA-Produktion moeglicherweise in der Pathophysiologie der Rheumatoiden Arthritis und anderer Autoimmunerkrankungen von Bedeutung ist ." ], "offsets": [ [ 0, 2379 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Nebennieren" ], "offsets": [ [ 4, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Nervensystems" ], "offsets": [ [ 80, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027763" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "autonomen Nervensystems" ], "offsets": [ [ 70, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004388" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Analysen" ], "offsets": [ [ 175, 183 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Immunhistochemie" ], "offsets": [ [ 188, 204 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021044" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "In-situ-Hybridisierung" ], "offsets": [ [ 207, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162788" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Technik" ], "offsets": [ [ 242, 249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039421" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Elektronenmikroskopie" ], "offsets": [ [ 292, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026019" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Elektronenmikroskopie" ], "offsets": [ [ 292, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013852" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t7", "type": "umlsterm", "text": [ "Elektronenmikroskopie" ], "offsets": [ [ 292, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026018" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t8", "type": "umlsterm", "text": [ "chromaffinen" ], "offsets": [ [ 340, 352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008574" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t9", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 353, 359 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t10", "type": "umlsterm", "text": [ "Nebennierenmarks" ], "offsets": [ [ 364, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001629" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t11", "type": "umlsterm", "text": [ "Nebennierenmarks" ], "offsets": [ [ 364, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t12", "type": "umlsterm", "text": [ "Nebennierenmarks" ], "offsets": [ [ 364, 380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376152" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t13", "type": "umlsterm", "text": [ "Steroid-produzierenden" ], "offsets": [ [ 389, 411 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 412, 418 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t15", "type": "umlsterm", "text": [ "Nebennierenrinde" ], "offsets": [ [ 423, 439 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t16", "type": "umlsterm", "text": [ "Nebennierenrinde" ], "offsets": [ [ 423, 439 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007452" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "type": "umlsterm", "text": [ "chromaffinen Zellen" ], "offsets": [ [ 340, 359 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376604" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Nebennierenmark" ], "offsets": [ [ 518, 533 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001629" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Nebennierenmark" ], "offsets": [ [ 518, 533 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Nebennierenmark" ], "offsets": [ [ 518, 533 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376152" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Gewebeverband" ], "offsets": [ [ 645, 658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Gewebeverband" ], "offsets": [ [ 645, 658 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013119" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Nebennierenrindenzelle" ], "offsets": [ [ 674, 696 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Nebennierenrindenzelle" ], "offsets": [ [ 674, 696 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "Innervation" ], "offsets": [ [ 724, 735 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021516" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t6", "type": "umlsterm", "text": [ "Kommunikation" ], "offsets": [ [ 763, 776 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009452" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t7", "type": "umlsterm", "text": [ "chromaffinen" ], "offsets": [ [ 781, 793 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008574" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 794, 800 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "type": "umlsterm", "text": [ "Blutgefaessen" ], "offsets": [ [ 807, 820 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005847" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "type": "umlsterm", "text": [ "Immunzellen" ], "offsets": [ [ 826, 837 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 892, 907 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "type": "umlsterm", "text": [ "stressbedingte" ], "offsets": [ [ 946, 960 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t13", "type": "umlsterm", "text": [ "chromaffinen Zellen" ], "offsets": [ [ 781, 800 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376604" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 1048, 1054 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Kokultur" ], "offsets": [ [ 1058, 1066 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0282547" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "chromaffinen" ], "offsets": [ [ 1071, 1083 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008574" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 1084, 1090 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Rindenzellen" ], "offsets": [ [ 1163, 1175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "chromaffinen Zellen" ], "offsets": [ [ 1071, 1090 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376604" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 1206, 1212 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 1231, 1237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Nebenniere" ], "offsets": [ [ 1415, 1425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Tiermodellen" ], "offsets": [ [ 1504, 1516 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Genen" ], "offsets": [ [ 1555, 1560 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Katecholaminbiosynthese" ], "offsets": [ [ 1565, 1588 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002508" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-t5", "type": "umlsterm", "text": [ "Katecholaminbiosynthese" ], "offsets": [ [ 1565, 1588 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005572" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Lymphozyten" ], "offsets": [ [ 1817, 1828 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024264" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Nebennierenzellen" ], "offsets": [ [ 1833, 1850 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Nebennierenzellen" ], "offsets": [ [ 1833, 1850 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Kommunikation" ], "offsets": [ [ 1899, 1912 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009452" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Wachstumsfaktoren" ], "offsets": [ [ 1958, 1975 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018284" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t3", "type": "umlsterm", "text": [ "Nebennierenzellen" ], "offsets": [ [ 2053, 2070 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "type": "umlsterm", "text": [ "Nebennierenzellen" ], "offsets": [ [ 2053, 2070 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "type": "umlsterm", "text": [ "Nebennierenwachstum" ], "offsets": [ [ 2100, 2119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001625" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "type": "umlsterm", "text": [ "Nebennierenwachstum" ], "offsets": [ [ 2100, 2119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "type": "umlsterm", "text": [ "Tumorbildung" ], "offsets": [ [ 2128, 2140 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Pathophysiologie" ], "offsets": [ [ 2282, 2298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 2316, 2325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "type": "umlsterm", "text": [ "Rheumatoiden Arthritis" ], "offsets": [ [ 2303, 2325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s1-r1-t1.1-t2.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s1-r2-t1.1-t3.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r1-t1.1-t8.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r2-t3.1-t4.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r3-t17.1-t15.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t15", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r4-t3.1-t12.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r5-t3.1-t8.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r6-t17.1-t4.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r7-t8.1-t12.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r8-t14.1-t15.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t15", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r9-t17.1-t12.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r10-t14.1-t8.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r11-t8.1-t15.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t15", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r12-t9.1-t8.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r13-t1.1-t6.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r14-t9.1-t12.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r15-t17.1-t12.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r16-t17.1-t16.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r17-t12.1-t4.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r18-t8.1-t14.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r19-t3.1-t6.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r20-t17.1-t11.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r21-t9.1-t15.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t15", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r22-t14.1-t12.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r23-t14.1-t12.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r24-t8.1-t9.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r25-t9.1-t4.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r26-t17.1-t10.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r27-t14.1-t11.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r28-t12.1-t8.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r29-t16.1-t4.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t16", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r30-t14.1-t10.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r31-t3.1-t1.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r32-t8.1-t12.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r33-t14.1-t16.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t14", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r34-t9.1-t16.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r35-t9.1-t12.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r36-t8.1-t11.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r37-t9.1-t11.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r38-t6.1-t4.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r39-t1.1-t4.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r40-t9.1-t10.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r41-t17.1-t8.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r42-t1.1-t12.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r43-t8.1-t10.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r44-t8.1-t4.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-r45-t8.1-t17.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s2-t17", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r1-t11.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r2-t7.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r3-t5.1-t11.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r4-t1.1-t4.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r5-t5.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r6-t5.1-t12.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r7-t12.1-t5.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r8-t2.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r9-t7.1-t5.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r10-t1.1-t2.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r11-t11.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r12-t11.1-t9.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r13-t9.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r14-t2.1-t12.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r15-t5.1-t12.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r16-t12.1-t11.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r17-t9.1-t11.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r18-t2.1-t5.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r19-t12.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r20-t2.1-t10.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r21-t2.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r22-t11.1-t5.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r23-t9.1-t8.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r24-t9.1-t12.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r25-t11.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r26-t1.1-t5.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r27-t9.1-t10.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r28-t2.1-t8.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r29-t7.1-t12.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r30-t12.1-t5.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r31-t11.1-t10.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r32-t9.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r33-t1.1-t13.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r34-t7.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r35-t7.1-t8.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r36-t1.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r37-t12.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r38-t1.1-t9.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r39-t12.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r40-t2.1-t13.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r41-t2.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r42-t9.1-t5.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r43-t2.1-t11.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r44-t7.1-t10.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r45-t11.1-t12.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r46-t2.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r47-t11.1-t8.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r48-t7.1-t11.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r49-t11.1-t13.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r50-t1.1-t8.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r51-t9.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r52-t9.1-t13.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r53-t7.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r54-t2.1-t12.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r55-t1.1-t12.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r56-t1.1-t11.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r57-t1.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r58-t7.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r59-t1.1-t10.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r60-t7.1-t9.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r61-t7.1-t13.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r62-t11.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-r63-t9.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-r1-t3.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-r2-t2.1-t3.1", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-r3-t3.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-r4-t3.1-t6.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s5-r5-t3.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-r1-t3.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-r2-t1.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-r3-t1.1-t2.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-r4-t3.1-t2.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s7-r5-t3.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s8-r1-t1.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s8-r2-t2.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s8-r3-t2.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s8-r4-t3.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r1-t4.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r2-t3.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r3-t4.1-t7.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r4-t4.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r5-t3.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r6-t4.1-t5.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r7-t5.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r8-t6.1-t7.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r9-t3.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r10-t4.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r11-t5.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r12-t2.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r13-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r14-t7.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r15-t7.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r16-t2.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r17-t2.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r18-t7.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r19-t3.1-t7.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r20-t2.1-t7.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r21-t6.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r22-t4.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r23-t5.1-t7.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r24-t6.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r25-t2.1-t7.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r26-t7.1-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r27-t5.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r28-t2.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r29-t7.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r30-t1.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r31-t2.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-r32-t5.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii12.ger.abstr-s10-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-passage-0", "type": "abstract", "text": [ "Zahlreiche Veteranen des Golfkriegs leiden unter vielfaeltigen Symptomen einschliesslich unspezifischer Hauterscheinungen und Arthralgien , die moeglicherweise eine gemeinsame immunologische Ursache haben . Andere Golfkriegsveteranen zeigen Symptome des Post-traumatic Stress Disorder ( PTSD ) , eine Angststoerung mit chronischer Stressreaktion . Ob chronischer Stress die Widerstandsfaehigkeit des Organismus gegen Krankheiten beeinflusst , wurde bislang nicht umfassend geklaert , neuere Forschungen aber belegen , dass ein gestoertes Gleichgewicht von Zytokinen , welche von T-Helferzellen produziert werden , stressvermittelte Krankheiten verursachen koennten . Es ist allgemein bekannt , dass eine ausgewogene Immunantwort ( zellvermittelt und humoral ) einen bedeutenden Abwehrmechanismus darstellt . Obwohl der Mechanismuns/die Mechanismen , welche die Balance des Immunsystems beeinflussen , nicht voellig klar sind , duerften stressinduzierte Veraenderungen des Cortisols und der Katecholamine verursachend sein , da beide sowohl die zellulaere als auch die humorale Immunitaet veraendern . Aufgrund dieser Zusammenhaenge untersuchten wir die Funktion sowohl des humoralen als auch des zellulaeren Arms des Immunsystems zusammen mit den Zytokinmustern dieser verschiedenen Immunfunktionen bei erkrankten Veteranen des Golfkriegs im Vergleich zu Kontrollgruppen von gesunden Golfkriegsveteranen und an erkrankten Patienten mit gleichen Symptomen , die nicht am Golfkrieg teilgenommen hatten ." ], "offsets": [ [ 0, 1501 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Veteranen" ], "offsets": [ [ 11, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042610" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Golfkriegs" ], "offsets": [ [ 25, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018041" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Golfkriegs" ], "offsets": [ [ 25, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043027" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Hauterscheinungen" ], "offsets": [ [ 104, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Arthralgien" ], "offsets": [ [ 126, 137 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003862" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Golfkriegsveteranen" ], "offsets": [ [ 214, 233 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018041" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Golfkriegsveteranen" ], "offsets": [ [ 214, 233 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043027" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Golfkriegsveteranen" ], "offsets": [ [ 214, 233 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042610" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Stress" ], "offsets": [ [ 269, 275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "PTSD" ], "offsets": [ [ 287, 291 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038436" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Angststoerung" ], "offsets": [ [ 301, 314 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003469" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-t7", "type": "umlsterm", "text": [ "Stressreaktion" ], "offsets": [ [ 331, 345 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Stress" ], "offsets": [ [ 363, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Krankheiten" ], "offsets": [ [ 417, 428 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Forschungen" ], "offsets": [ [ 491, 502 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Gleichgewicht" ], "offsets": [ [ 538, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014653" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-t5", "type": "umlsterm", "text": [ "Krankheiten" ], "offsets": [ [ 632, 643 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Immunsystems" ], "offsets": [ [ 873, 885 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "stressinduzierte" ], "offsets": [ [ 936, 952 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Cortisols" ], "offsets": [ [ 972, 981 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020268" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Katecholamine" ], "offsets": [ [ 990, 1003 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007412" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Immunitaet" ], "offsets": [ [ 1077, 1087 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020964" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "humorale Immunitaet" ], "offsets": [ [ 1068, 1087 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003261" }, { "db_name": "UMLS", "db_id": "C0020967" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Arms" ], "offsets": [ [ 1208, 1212 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003792" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Immunsystems" ], "offsets": [ [ 1217, 1229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Veteranen" ], "offsets": [ [ 1314, 1323 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042610" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Golfkriegs" ], "offsets": [ [ 1328, 1338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018041" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "type": "umlsterm", "text": [ "Golfkriegs" ], "offsets": [ [ 1328, 1338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043027" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "type": "umlsterm", "text": [ "Golfkriegsveteranen" ], "offsets": [ [ 1384, 1403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018041" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "type": "umlsterm", "text": [ "Golfkriegsveteranen" ], "offsets": [ [ 1384, 1403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043027" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "type": "umlsterm", "text": [ "Golfkriegsveteranen" ], "offsets": [ [ 1384, 1403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042610" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1422, 1431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t10", "type": "umlsterm", "text": [ "Golfkrieg" ], "offsets": [ [ 1470, 1479 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018041" } ] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t11", "type": "umlsterm", "text": [ "Golfkrieg" ], "offsets": [ [ 1470, 1479 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043027" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-r1-t5.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-r2-t1.1-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-r3-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s1-r4-t2.1-t3.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r1-t5.1-t7.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r2-t7.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r3-t4.1-t6.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r4-t3.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r5-t3.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r6-t3.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r7-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r8-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r9-t4.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r10-t4.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r11-t4.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r12-t7.1-t5.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r13-t6.1-t4.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r14-t1.1-t2.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r15-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r16-t5.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r17-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r18-t6.1-t7.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r19-t5.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r20-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r21-t6.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r22-t4.1-t5.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r23-t5.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r24-t6.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r25-t7.1-t6.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r26-t6.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r27-t1.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r28-t1.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r29-t6.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r30-t1.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r31-t7.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r32-t5.1-t4.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r33-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r34-t7.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r35-t3.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r36-t7.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s2-r37-t7.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r1-t2.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r2-t2.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r3-t4.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r4-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r5-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r6-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r7-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r8-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r9-t4.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r10-t1.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r11-t4.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r12-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r13-t3.1-t4.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r14-t5.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r15-t1.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r16-t5.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r17-t5.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r18-t1.1-t2.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r19-t1.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r20-t1.1-t5.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r21-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s3-r22-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r2-t5.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r3-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r4-t3.1-t6.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r5-t4.1-t6.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r6-t6.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r7-t6.2-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r8-t6.2-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r9-t2.1-t6.2", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r10-t6.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r11-t2.1-t6.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r12-t6.2-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r13-t5.1-t6.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r14-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r15-t2.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r16-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r17-t5.1-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r18-t5.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r19-t6.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r20-t2.1-t6.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r21-t6.2-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r22-t5.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r23-t4.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r24-t6.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r25-t3.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r26-t2.1-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r27-t6.2-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r28-t4.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r29-t2.1-t5.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r30-t2.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r31-t3.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r32-t3.1-t2.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r33-t4.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-r34-t6.1-t6.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r1-t9.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r2-t8.1-t9.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r3-t8.1-t7.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r4-t8.1-t11.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r5-t10.1-t11.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t10", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r6-t8.1-t6.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r7-t3.1-t11.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r8-t8.1-t10.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r9-t3.1-t7.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r10-t3.1-t9.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r11-t6.1-t7.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r12-t4.1-t7.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r13-t3.1-t10.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r14-t8.1-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r15-t10.1-t7.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t10", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r16-t3.1-t6.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r17-t6.1-t11.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r18-t4.1-t11.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r19-t8.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r20-t9.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r21-t3.1-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r22-t1.1-t2.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r23-t9.1-t7.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r24-t9.1-t11.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r25-t3.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r26-t6.1-t5.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r27-t9.1-t8.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r28-t9.1-t6.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r29-t4.1-t5.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r30-t10.1-t5.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t10", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r31-t9.1-t10.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-r32-t9.1-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t9", "arg2_id": "ZfuerRheumatologie.0059ii124.ger.abstr-s6-t5", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii127.ger.abstr-passage-0", "type": "abstract", "text": [ "Fragestellung : Es sollte herausgefunden werden , was Kinderrheumatologen unter einer niedrigdosierten Kortikosteroid-Langzeittherapie ( low-dose long-term corticosteroid therapy ) , verstehen ." ], "offsets": [ [ 0, 194 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii127.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "corticosteroid" ], "offsets": [ [ 156, 170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001617" } ] } ]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-passage-0", "type": "abstract", "text": [ "Die systemische Osteoporose gilt als eine haeufige und pathogenetisch heterogene Komplikation bei entzuendlich-rheumatischen Erkrankungen . Ausgehend von der Annahme , dass der Knochenabbau durch inflammatorische Prozesse beschleunigt ablaeuft , wurde in der vorliegenden Prospektivstudie der Knochenmetabolismus bei insgesamt 51 Patienten ( innen ) , davon 29 mit Spaetform einer rheumatoiden Arthritis und 22 mit einer Polymyalgia rheumatica zum Diagnosezeitpunkt und nach 6- bis 7-monatiger Glukokortikoidtherapie untersucht . Zur Objektivierung der Knochenmasse wurde die Photonenabsorptionsmetrie ( DEXA ) an den Lendenwirbelkoerpern 2-4 ap , seitlich und am Ward'schen Dreieck des linken Schenkelhalses angewandt , die biochemische Analyse umfasste die Bestimmung von Markern der Osteoblastenaktivitaet ( Osteokalzin alkalische Phosphatase und Ostase ) . , Zum Diagnosezeitpunkt bestand noch keine rheumatische Therapie , im weiteren Verlauf wurde eine initiale Glukokortikoidgabe von 25-30 mg/Tag eingeleitet mit anschliessender Reduktion . Eine Langzeittherapie bestand waehrend des Beobachtungszeitraumes ebenso wenig wie eine den Knochenmetabolismus beeinflussende Medikation . Zum Diagnosezeitpunkt ergaben sich in beiden Patientenkollektiven keine pathologischen Veraenderungen des Knochenmetabolismus im Sinne einer Osteoporose , nach 6- bis 7-monatiger Therapie waren bei 16/51 Patienten ( innen 31% ) ) ( erniedrigte Knochendichtewerte ( T-Score -2 , 5 SD ) und teils pathologische Veraenderungen der biochemischen Knochenmarker verifizierbar , davon bei 10/29 Patienten ( innen ) mit Spaetform einer rheumatoiden Arthritis und 6/22 Patienten ( innen ) mit Polymyalgia rheumatica . Zusammenfassend laesst sich in den ersten Monaten unter einer systemischen Glukokortikoidgabe einer Spaerform einer rheumatoiden Arthritis als auch einer Polymyalgia rheumatica nur bei einem Drittel der Patienten ( innen ) eine Alteration des Knochenmetabolismus verifizieren , so dass die Glukokortikoide neben einer adaequaten Suppression des inflammatorischen Prozesses wohl eine osteoprotektive Wirkung bei einem ueberwiegenden Teil der Patienten ( innen ) bewirken . In therapeutischer als auch prophylaktischer Hinsicht unterstuetzen die Ergebnisse die Forderung , bei hohem Steroidbedarf moeglichst rasch , d . h . schon in den ersten Monaten nach Diagnosestellung , eine weitere immunsuppressive Langzeittherapie einzuleiten , um die zunaechst vorhandene osteoprotektive Glukokortikoidwirkung nicht in einen osteoporoseinduzierenden Mechanismus - als mit gravierendste Nebenwirkung einer langfristigen Glukokortikoidtherapie - umzuwandeln ." ], "offsets": [ [ 0, 2645 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Osteoporose" ], "offsets": [ [ 16, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Komplikation" ], "offsets": [ [ 81, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Knochenabbau" ], "offsets": [ [ 177, 189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 330, 339 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 394, 403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Diagnosezeitpunkt" ], "offsets": [ [ 448, 465 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 381, 403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Polymyalgia rheumatica" ], "offsets": [ [ 421, 443 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032533" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Knochenmasse" ], "offsets": [ [ 553, 565 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "DEXA" ], "offsets": [ [ 604, 608 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011322" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Lendenwirbelkoerpern" ], "offsets": [ [ 618, 638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024091" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Analyse" ], "offsets": [ [ 738, 745 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t5", "type": "umlsterm", "text": [ "Markern" ], "offsets": [ [ 774, 781 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t6", "type": "umlsterm", "text": [ "Osteoblastenaktivitaet" ], "offsets": [ [ 786, 808 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029418" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t7", "type": "umlsterm", "text": [ "alkalische Phosphatase" ], "offsets": [ [ 823, 845 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002059" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Diagnosezeitpunkt" ], "offsets": [ [ 867, 884 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 917, 925 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Langzeittherapie" ], "offsets": [ [ 1053, 1069 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Langzeittherapie" ], "offsets": [ [ 1053, 1069 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Diagnosezeitpunkt" ], "offsets": [ [ 1192, 1209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Patientenkollektiven" ], "offsets": [ [ 1233, 1253 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Osteoporose" ], "offsets": [ [ 1329, 1340 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 1367, 1375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t5", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1392, 1401 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t6", "type": "umlsterm", "text": [ "Knochendichtewerte" ], "offsets": [ [ 1432, 1450 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "type": "umlsterm", "text": [ "Knochenmarker" ], "offsets": [ [ 1530, 1543 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t8", "type": "umlsterm", "text": [ "Knochenmarker" ], "offsets": [ [ 1530, 1543 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t9", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1576, 1585 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t10", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 1629, 1638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t11", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1648, 1657 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t12", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 1616, 1638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t13", "type": "umlsterm", "text": [ "Polymyalgia rheumatica" ], "offsets": [ [ 1672, 1694 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032533" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 1826, 1835 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1900, 1909 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 1987, 2002 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 2138, 2147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t5", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 1813, 1835 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "type": "umlsterm", "text": [ "Polymyalgia rheumatica" ], "offsets": [ [ 1851, 1873 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032533" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Steroidbedarf" ], "offsets": [ [ 2278, 2291 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Diagnosestellung" ], "offsets": [ [ 2352, 2368 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "Langzeittherapie" ], "offsets": [ [ 2401, 2417 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "type": "umlsterm", "text": [ "Langzeittherapie" ], "offsets": [ [ 2401, 2417 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "type": "umlsterm", "text": [ "osteoporoseinduzierenden" ], "offsets": [ [ 2513, 2537 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s1-r1-t2.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s1-r2-t1.1-t2.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r1-t1.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r2-t6.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r3-t6.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r4-t3.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r5-t1.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r6-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r7-t4.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r8-t4.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s2-r9-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r1-t6.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r2-t3.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r3-t7.1-t5.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r4-t4.1-t5.2", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r5-t7.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r6-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r7-t3.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r8-t6.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r9-t3.1-t6.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r10-t7.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r11-t4.1-t2.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r12-t5.2-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r13-t2.1-t7.1", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r14-t6.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r15-t1.1-t3.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r16-t4.1-t7.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r17-t1.1-t6.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r18-t4.1-t2.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r19-t7.1-t6.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r20-t1.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r21-t6.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r22-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r23-t2.1-t5.2", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r24-t4.1-t7.1", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r25-t6.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r26-t4.1-t5.2", "type": "measures", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s3-r27-t1.1-t6.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r1-t7.1-t12.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r2-t8.2-t12.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r3-t4.1-t10.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r4-t4.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r5-t6.1-t10.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r6-t7.1-t6.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r7-t6.1-t7.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r8-t7.1-t10.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r9-t8.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r10-t6.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r11-t6.1-t13.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r12-t4.1-t9.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r13-t7.1-t6.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r14-t8.2-t10.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r15-t6.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r16-t7.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r17-t8.2-t13.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r18-t6.1-t12.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r19-t4.1-t11.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r20-t4.1-t4.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r21-t6.1-t7.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r22-t7.1-t13.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r23-t4.1-t13.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r24-t8.2-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t8", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r25-t7.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t7", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r26-t4.1-t12.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s6-r27-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r1-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r2-t6.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r3-t1.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r4-t5.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r5-t5.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r6-t3.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r7-t6.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r8-t6.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r9-t1.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r10-t3.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r11-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-r12-t5.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.0059ii137.ger.abstr-s10-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-passage-0", "type": "abstract", "text": [ "Bis vor kurzem galt das Zentralnervensystem ( ZNS ) als ein immunprivilegiertes Organ , d . h . , ein Organ das keiner Immunueberwachung unterliegt . Man ging davon aus , dass die hochspezialisierte endotheliale Blut-Hirn-Schranke ( BHS ) eine unueberwindbare Barriere fuer zirkulierende Lymphozyten darstellt . Waehrend entzuendlicher Prozesse im ZNS erhalten jedoch zahlreiche mononukleaere Zellen Zugang zum ZNS Parenchym . Die molekularen Mechanismen der Rekrutierung von Lymphozyten durch die BHS wurden bislang vorwiegend im Tiermodell der experimentellen autoimmunen Enzephalomyelitis ( EAE ) studiert . Die EAE ist das beste derzeit verfuegbare Modell fuer humane entzuendliche demyelinisierende Erkrankungen des ZNS wie der Multiplen Sklerose ( MS ) . Da Endothelzellen aktiv den Eintritt von Lymphozyten in Organe regulieren , kann man davon ausgehen , dass das spezialisierte BHS-Endothel spezifische Rezeptoren , die als Verkehrssignale \" \" fuer zirkulierende Leukozyten dienen , exprimiert . Die Identifizierung dieser BHS-spezifischen \" Verkehrssignale \" ist von grosser klinischer Bedeutung , da ihre Blockade eine selektive Inhibition einer im ZNS ablaufenden Entzuendungsreaktion erlauben wuerde . Eine solche Therapie steht zur Zeit noch nicht zur Verfuegung . Vielmehr wird die akute MS mit hochdosierten Glukokortikoiden therapiert . Die bislang vorliegenden Evidenzen , dass der Erfolg der Glukokortikoidtherapie auf der Inhibition der Expression von Adhaesionsmolekuelen und somit der Inhibition der Lymphozyten-Rekrutierung durch die BHS beruht , wird diskutiert ." ], "offsets": [ [ 0, 1587 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Zentralnervensystem" ], "offsets": [ [ 24, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007679" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "ZNS" ], "offsets": [ [ 46, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007679" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Immunueberwachung" ], "offsets": [ [ 119, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026428" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Blut-Hirn-Schranke" ], "offsets": [ [ 212, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Blut-Hirn-Schranke" ], "offsets": [ [ 212, 230 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Lymphozyten" ], "offsets": [ [ 288, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024264" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "ZNS" ], "offsets": [ [ 348, 351 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007679" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 393, 399 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "ZNS" ], "offsets": [ [ 411, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007679" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Lymphozyten" ], "offsets": [ [ 476, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024264" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Tiermodell" ], "offsets": [ [ 531, 541 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Enzephalomyelitis" ], "offsets": [ [ 574, 591 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014070" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "ZNS" ], "offsets": [ [ 721, 724 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007679" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Sklerose" ], "offsets": [ [ 743, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036429" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Endothelzellen" ], "offsets": [ [ 764, 778 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014257" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Endothelzellen" ], "offsets": [ [ 764, 778 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Lymphozyten" ], "offsets": [ [ 802, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024264" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "type": "umlsterm", "text": [ "Leukozyten" ], "offsets": [ [ 972, 982 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023516" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "ZNS" ], "offsets": [ [ 1160, 1163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007679" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 1227, 1235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "Zeit" ], "offsets": [ [ 1246, 1250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "type": "umlsterm", "text": [ "Lymphozyten-Rekrutierung" ], "offsets": [ [ 1522, 1546 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024264" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r1-t3.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r2-t1.2-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r3-t3.1-t1.2", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r4-t1.1-t1.2", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r5-t1.2-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r6-t1.2-t1.1", "type": "derivative_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r7-t3.1-t1.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r8-t1.1-t3.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s4-r9-t1.1-t1.2", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s5-r1-t2.1-t1.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s5-r2-t2.1-t3.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s6-r1-t1.1-t2.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s6-r2-t3.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s6-r3-t1.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s6-r4-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r1-t3.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r2-t2.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r3-t4.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r4-t4.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r5-t1.1-t4.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r6-t1.1-t2.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r7-t1.1-t4.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r8-t3.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r9-t4.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r10-t4.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r11-t2.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-r12-t1.1-t3.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.0059ii18.ger.abstr-s8-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-passage-0", "type": "abstract", "text": [ "Im Gehirn und in der Hypophyse kommen zwei Arten von Kortikosteroid-Rezeptoren vor , die eine wichtige Rolle bei der Regulation der Hypothalamus-Hypophysen-Nebennierenrinden-Achse spielen . Diese beiden Rezeptoren , der Mineralokortikoid-Rezeptor ( MR ) und der Glukokortikoid-Rezeptor , binden Glukokortikoidhormone . Offensichtlich ist eine genaue Kontrolle der Konzentration und Funktion dieser Rezeptoren ausserordentlich wichtig fuer den Erhalt und die Wiederherstellung der Homoeostase nach stressvollen Ereignissen . Hier beschreiben wir einen neuen Mechanismus , der einen raschen Anstieg der MR-Dichte im Hippocampus ( limbische Struktur , die ganz wesentlich in die HPA-Achsen-Regulation involviert ist ) nach einer akuten , psychologisch stressvollen Herausforderung zeigt . Dieser MR-Anstieg geht mit einem staerkeren - MR-vermittelten - inhibierenden Einfluss auf die HPA-Achse einher . Somit resultiert eine akute stressvolle Erfahrung in einer Reorganisation der HPA-Achse , bei welcher dem hippocampalen MR eine Hauptrolle zuzuschreiben ist . Dieser neue Mechanismus koennte fuer die Erweiterung unseres Verstaendnisses hinsichtlich der Entstehung stressbedingter Erkrankungen von Bedeutung sein ." ], "offsets": [ [ 0, 1213 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Gehirn" ], "offsets": [ [ 3, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Hypophyse" ], "offsets": [ [ 21, 30 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032005" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 103, 108 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Konzentration" ], "offsets": [ [ 364, 377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Wiederherstellung" ], "offsets": [ [ 458, 475 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009940" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Homoeostase" ], "offsets": [ [ 480, 491 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019868" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "stressvollen" ], "offsets": [ [ 497, 509 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "stressvollen" ], "offsets": [ [ 749, 761 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "stressvolle" ], "offsets": [ [ 928, 939 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Erweiterung" ], "offsets": [ [ 1100, 1111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012356" } ] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "stressbedingter" ], "offsets": [ [ 1164, 1179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r1-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r2-t4.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r3-t1.1-t3.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r4-t3.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r5-t3.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r6-t1.1-t3.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r7-t4.1-t3.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r8-t1.1-t3.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r9-t4.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r10-t4.1-t1.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r11-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r12-t1.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-r13-t3.1-t1.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii22.ger.abstr-s7-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-passage-0", "type": "abstract", "text": [ "Wegen ihrer anti-inflammatorischen Effekte und ihrer Potenz , die Synthese der meisten Zytokine und die Balance Th1/Th2 zu beeinflussen , tragen die endogenen Glukokortikoide zur basalen Regulation der Immunzellen bei . Immunologische Prozesse verursachen die Produktion von Zytokinen , wie IL-1, IL-2, IL-6, IL-11, IL-12, TNF- , INF- , welche ihrerseits die HPA Achse stimulieren koennen . Der dadurch vermittelte Anstieg von Glukokortikoiden wirkt entweder direkt oder ueber die Beeinflussung der Produktion von Zytokinen auf immunologische Zellen , was die Existenz eines zytokinvermittelten immunregulatorischen Regelkreises mit der HPA Achse nahelegt . Es gilt als gesichert , dass dieser Regelkreis eine bedeutsame Rolle spielt bei der Kontrolle einer ueberschiessenden Immunantwort und der Unterdrueckung der Expansion von Immunzellen mit fehlender oder nur geringer Affinitaet zu Antigenen , welche die spezifische Immunantwort ausloesen ." ], "offsets": [ [ 0, 947 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Zytokine" ], "offsets": [ [ 87, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079189" } ] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 159, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Immunzellen" ], "offsets": [ [ 202, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 543, 549 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 721, 726 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Immunzellen" ], "offsets": [ [ 830, 841 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Antigenen" ], "offsets": [ [ 888, 897 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003320" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-r1-t1.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-r2-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-r3-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-r4-t2.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-r5-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s1-r6-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-r2-t3.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059ii26.ger.abstr-s4-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-passage-0", "type": "abstract", "text": [ "Es gilt als gesichert , dass ein immunregulatorischer Regelkreis von Zytokinen mit der Achse Hypothalamus-Hypophyse-Nebennierenrinde /HPA) waehrend verschiedenster pathologischer Ablaeufe wirksam ist . So konnte beispielsweise gezeigt werden , dass IL-1 der wichtigste Mediator des Anstiegs von ACTH und Kortikosteron im Blut in Tiermodellen viraler Infektion und bakterieller Endotoxine ist . Diese endokrinologische Antwort hat protektive Effekte im septischen Schock . In experimentellen Tumormodellen ergaben sich ebenfalls klare Hinweise , dass der Glukokortikoidanstieg im Blut , welcher waehrend des Wachstums von Lymphomen beobachtet wird , durch Mediatoren des Immunsystems vermittelt ist und den begleitenden Entzuendungsprozess hemmt . Die Unterbrechung des Zytokin-HPA-Achse-Regelkreises kann fuer die Autoimmunerkrankungen praedisponieren . Dies konnte fuer die Tiermodelle der spontanen Autoimmunthyreoiditis , Lupus-aehnlicher Erkrankungen und experimenteller Arthritiden gezeigt werden . Erst kuerzlich wurde demonstriert , dass der intakte Regelkreis zur Vermeidung oder mindestens Abschwaechung autoimmunologischer Reaktionen beitraegt . Die Erholung von Tieren mit experimenteller Autoimmunenzephalitis ( EAE ) eindeutig abhaengig vom Anstieg endogener Glukokortikoide . So konnte gezeigt werden , dass diese endokrine Antwort zumindest teilweise durch die Immunantwort gegen das Enzephalitis-ausloesende Antigen vermittelt ist und zwar durch das IL-1, welches waehrend der Erkrankung gebildet wird . Diese Beispiele verdeutlichen das Konzept einer protektiven Rolle , die der Zytokin-HPA-Achsen-Regelkreis waehrend verschiedener pathologischer Zustaende spielt . Seine Stoerung kann zur Ausloesung von Autoimmunerkrankungen beitragen oder ihren Verlauf unguenstig beeinflussen ." ], "offsets": [ [ 0, 1798 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "IL-1" ], "offsets": [ [ 249, 253 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021755" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "ACTH" ], "offsets": [ [ 295, 299 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001655" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Blut" ], "offsets": [ [ 321, 325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Tiermodellen" ], "offsets": [ [ 329, 341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Infektion" ], "offsets": [ [ 350, 359 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Endotoxine" ], "offsets": [ [ 377, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014264" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Tumormodellen" ], "offsets": [ [ 491, 504 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Blut" ], "offsets": [ [ 579, 583 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Wachstums" ], "offsets": [ [ 607, 616 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018270" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Lymphomen" ], "offsets": [ [ 621, 630 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024299" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "Immunsystems" ], "offsets": [ [ 670, 682 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Tiermodelle" ], "offsets": [ [ 875, 886 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Autoimmunthyreoiditis" ], "offsets": [ [ 901, 922 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0677607" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Erholung" ], "offsets": [ [ 1160, 1168 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034872" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Tieren" ], "offsets": [ [ 1173, 1179 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 1272, 1287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Enzephalitis-ausloesende" ], "offsets": [ [ 1399, 1423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014038" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Antigen" ], "offsets": [ [ 1424, 1431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003320" } ] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 1580, 1585 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r1-t5.1-t3.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r2-t6.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r3-t6.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r4-t1.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r5-t5.1-t3.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r6-t6.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r7-t5.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r8-t5.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r9-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r10-t6.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r11-t3.1-t3.2", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r12-t2.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r13-t3.1-t3.2", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r14-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r15-t3.1-t4.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r16-t3.2-t3.1", "type": "derivative_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r17-t1.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r18-t5.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r19-t3.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r20-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r21-t2.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r22-t3.2-t2.1", "type": "consists_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r23-t3.2-t5.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r24-t1.1-t5.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r25-t1.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r26-t5.1-t3.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r27-t3.2-t1.1", "type": "consists_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r28-t5.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r29-t2.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s2-r30-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r1-t2.2-t4.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r2-t2.2-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r3-t2.2-t5.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r4-t1.1-t2.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r5-t2.2-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r6-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r7-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r8-t4.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r9-t2.2-t2.1", "type": "derivative_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r10-t4.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r11-t4.1-t2.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r12-t2.1-t2.2", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r13-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r14-t2.1-t5.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r15-t2.1-t2.2", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r16-t1.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s4-r17-t2.2-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s6-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s6-r2-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s8-r1-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-r1-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-r2-t2.1-t1.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii31.ger.abstr-s10-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-passage-0", "type": "abstract", "text": [ "Im Zuge psycho-neuroimmunologischer Forschung ist inzwischen gesichert , dass das Immunsystem mannigfaltigen Einfluessen des Zentralnervensystems unterliegt . Eine Strategie zur Untersuchung dieser Interaktionen ist die Stressforschung . Waehrend das Phaenomen stressinduzierter Veraenderungen immunologischer Parameter bereits lange bekannt ist , konzentrieren sich neuere Arbeiten auf moegliche Moderatoren und Mechanismen solcher Reaktionen . Die bisherigen Ergebnisse belegen , dass der Freisetzung von Katecholaminen eine fundamentale Bedeutung in der oftmals beobachteten Stress-induzierten Leukozytose zukommt . Die vorliegende Studie wurde durchgefuehrt , um zu pruefen , ob Veraenderungen der Anzahl von Lymphozyten im peripheren Blut in vergleichbarer Weise von Noradrenalin- bzw. Adrenalinanstiegen nach Belastung abhaengen . Des weiteren war von Interesse , ob das Ausmass katecholaminerger Veraenderungen mit dem der subjektiven Befindlichkeit assoziiert ist . Unter Verwendung des Paradigmas der Oeffentlichen Rede \" \" gelang es , bislang publizierte Befunde stressbedingter Anstiege der peripheren CD8+- und CD56+-Zellen zu replizieren . Nach Einteilung der Probanden in solche mit hoher vs. niedriger Katecholaminfreisetzung zeigte sich deutlich , dass die Highresponder \" \" mit den deutlicheren zellulaeren Veraenderungen reagierten ungeachtet , dessen , ob Noradrenalinreaktionen oder solche des Adrenalins als Einteilungskriterium herangezogen wurden . \" High responder \" unterschieden sich aber nicht in Hinblick auf subjektive Angaben zum Stresserleben . Die Ergebnisse werden vor dem Hintergrund moeglicher Mechanismen katecholaminerger Einfluesse auf das Migrationsverhalten lymphoider Zellen , aber auch hinsichtlich der vermeintlichen Diskrepanz zwischen objektiven und subjektiven Indikatoren der Stressorwirksamkeit diskutiert ." ], "offsets": [ [ 0, 1855 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 36, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Immunsystem" ], "offsets": [ [ 82, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Zentralnervensystems" ], "offsets": [ [ 125, 145 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007679" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Stressforschung" ], "offsets": [ [ 220, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Stressforschung" ], "offsets": [ [ 220, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "stressinduzierter" ], "offsets": [ [ 261, 278 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Arbeiten" ], "offsets": [ [ 374, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Katecholaminen" ], "offsets": [ [ 507, 521 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002508" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Stress-induzierten" ], "offsets": [ [ 578, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Leukozytose" ], "offsets": [ [ 597, 608 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023518" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Lymphozyten" ], "offsets": [ [ 713, 724 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024264" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Blut" ], "offsets": [ [ 739, 743 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Noradrenalin-" ], "offsets": [ [ 772, 785 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028351" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Belastung" ], "offsets": [ [ 815, 824 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015264" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Verwendung" ], "offsets": [ [ 980, 990 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "stressbedingter" ], "offsets": [ [ 1073, 1088 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Katecholaminfreisetzung" ], "offsets": [ [ 1217, 1240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002508" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Noradrenalinreaktionen" ], "offsets": [ [ 1375, 1397 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028351" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Adrenalins" ], "offsets": [ [ 1414, 1424 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014563" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 1709, 1715 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "lymphoider Zellen" ], "offsets": [ [ 1698, 1715 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086574" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s2-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s2-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s3-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s3-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s4-r1-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s4-r2-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s4-r3-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s4-r4-t1.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r1-t1.1-t2.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r2-t2.1-t2.2", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r3-t2.2-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r4-t2.2-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r5-t2.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r6-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r7-t4.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r8-t2.2-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r9-t1.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r10-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r11-t2.2-t2.1", "type": "derivative_of", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-r12-t2.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-r3-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-r4-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-r5-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-r6-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.0059ii43.ger.abstr-s8-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-passage-0", "type": "abstract", "text": [ "Ausgehend von vorangegangenen Befunden , wonach Stoerungen des Feedbacks zwischen Immunsystem und Gehirn zu pathogenen Immunreaktionen praedisponieren , konzentriert sich unser Interesse auf die Rolle von adrenergen/cholinergen Neurotransmittern im Rahmen der Neuroimmunomodulation . Die Daten im Ratten- und Mausmodell zeigen , dass 1 ) sowohl Katecholamine als auch Azetylcholin potente immunregulatorische Eigenschaften besitzen , 2 cholinerge Mechanismen ) entscheidend an den afferenten Signalen des aktivierten Immunsystems beteiligt sind , und 3 Lymphozyten ) nicht nur funktionelle adrenerge/cholinerge Rezeptoren exprimieren , sondern auch in der Lage sind Neurotransmitter , wie Azetylcholin , , zu synthetisieren und in quantitativer Abhaengigkeit des zellulaeren Aktivierungszustandes zu sezernieren . Laufende Untersuchungen haben zum Ziel , die Rolle dieser nicht neuronalen Neurotransmitter in Immungewegen , sowie die Relevanz exzitatorischer Aminosaeuren als wichtige zentrale Neurotransmitter im Rahmen des Dialoges Gehirn-Immunsystem aufzuklaeren ." ], "offsets": [ [ 0, 1067 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Feedbacks" ], "offsets": [ [ 63, 72 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015744" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Immunsystem" ], "offsets": [ [ 82, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Gehirn" ], "offsets": [ [ 98, 104 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 195, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Neurotransmittern" ], "offsets": [ [ 228, 245 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027908" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Ratten-" ], "offsets": [ [ 297, 304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034693" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Mausmodell" ], "offsets": [ [ 309, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025914" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Katecholamine" ], "offsets": [ [ 345, 358 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007412" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Immunsystems" ], "offsets": [ [ 517, 529 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Lymphozyten" ], "offsets": [ [ 553, 564 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024264" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Neurotransmitter" ], "offsets": [ [ 666, 682 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027908" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 859, 864 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Neurotransmitter" ], "offsets": [ [ 889, 905 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027908" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Aminosaeuren" ], "offsets": [ [ 959, 971 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002520" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Neurotransmitter" ], "offsets": [ [ 994, 1010 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027908" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "type": "umlsterm", "text": [ "Gehirn-Immunsystem" ], "offsets": [ [ 1034, 1052 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t6", "type": "umlsterm", "text": [ "Gehirn-Immunsystem" ], "offsets": [ [ 1034, 1052 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-r1-t3.1-t2.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-r2-t3.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-r3-t5.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s1-r4-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r1-t3.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r2-t6.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t6", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r3-t5.1-t6.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r4-t5.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r5-t3.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r6-t5.1-t2.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r7-t6.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t6", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r8-t5.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s2-r9-t5.1-t4.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r1-t3.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r2-t4.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r3-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r4-t5.1-t6.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r5-t5.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r6-t4.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r7-t5.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r8-t2.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r9-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r10-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r11-t5.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r12-t2.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-r13-t4.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.0059ii49.ger.abstr-s3-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-passage-0", "type": "abstract", "text": [ "Kontrollierte Studien adrenaler Steroide bei praemenopausalen Frauen mit rheumatoider Arthritis ( RA ) ergaben subtile und widerspruechliche Erniedrigungen der Funktion der Glukokortikoidsteroide ( GKS ) , aber deutliche Defizite adrenerger Androgener ( AA ) . Diese Ergebnisse legten den Schluss nahe , dass Hypoandrogenitaet bei jungen Frauen zur RA disponieren koennte . Neuere prospektive Studien mit Bestimmungen von Kortisol und Dehydroepiandrosteronsulfat ( DHEAS ) im Serum vor dem Beginn der RA ( x = 12 Jahre ) bieten jedoch eine andere Perspektive . Eine signifikante Dissoziation der Serumspiegel von Kortisol und DHEAS wurde allein in jener Subgruppe praemenopausaler Frauen gefunden , die die RA vor dem 50. Lebensjahr manifestierten . Nur diese Subgruppe hatte deutlich niedrigere Spiegel fuer DHEAS ." ], "offsets": [ [ 0, 816 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Steroide" ], "offsets": [ [ 32, 40 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 62, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 86, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Androgener" ], "offsets": [ [ 241, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002844" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "rheumatoider Arthritis" ], "offsets": [ [ 73, 95 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 338, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Kortisol" ], "offsets": [ [ 422, 430 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020268" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Dehydroepiandrosteronsulfat" ], "offsets": [ [ 435, 462 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0057277" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Dissoziation" ], "offsets": [ [ 579, 591 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086168" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Kortisol" ], "offsets": [ [ 613, 621 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020268" } ] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 681, 687 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r1-t4.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r2-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r3-t4.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r4-t5.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r5-t3.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r6-t5.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r7-t1.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r8-t1.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r9-t4.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r10-t2.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r11-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s1-r12-t1.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s3-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s3-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-r1-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-r2-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.0059ii54.ger.abstr-s4-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-passage-0", "type": "abstract", "text": [ "Die rheumatoide Arthritis ( RA ) ist eine systemische entzuendliche Erkrankung mit erhoehten Spiegeln proinflammatorischer Zytokine im peripheren Blut , z . B. Interleukin-6 ( IL-6), Interleukin-1 ( IL-1) und Tumornekrosisfaktor ( TNF ) , die immunologische Aktivitaet der Erkrankung reflektieren . Eine veraenderte zirkadiane Rhythmik des Kortisols mit insgesamt erhoehter Kortisolfreisetzung in Abhaengigkeit von der entzuendlichen Aktivitaet der RA ist bekannt ." ], "offsets": [ [ 0, 465 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 16, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Zytokine" ], "offsets": [ [ 123, 131 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079189" } ] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Blut" ], "offsets": [ [ 146, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "rheumatoide Arthritis" ], "offsets": [ [ 4, 25 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Interleukin-6" ], "offsets": [ [ 160, 173 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021760" } ] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Interleukin-1" ], "offsets": [ [ 183, 196 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021755" } ] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Rhythmik" ], "offsets": [ [ 327, 335 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031084" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r1-t3.2-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r2-t2.1-t3.2", "type": "indicates", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r3-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r5-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r6-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r8-t3.2-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r9-t1.1-t3.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r11-t3.2-t2.1", "type": "consists_of", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r13-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r14-t2.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r15-t2.1-t1.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r16-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-r17-t2.1-t3.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.0059ii62.ger.abstr-s3-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-passage-0", "type": "abstract", "text": [ "Der guenstige Einfluss einer Schwangerschaft auf die rheumatoide Arthritis ( RA ) ist seit 1938 bekannt und wurde mehrfach fuer 75% der RA-Schwangerschaften bestaetigt . Eine Besserung der Symptome macht sich in der Regel schon im ersten Trimester bemerkbar und nimmt im Verlauf der Schwangerschaft zu . Eine Verschlechterung der RA wird bei den meisten Patienten innerhalb von 6 Monaten nach der Entbindung beobachtet . Zunaechst glaubte man , die Besserung sei durch den Anstieg des Kortisols waehrend der Schwangerschaft verursacht , doch wiesen drei Studien der Fuenfziger und Sechziger Jahre keinen Zusammenhang zwischen den Kortisolspiegeln und der Krankheitsaktivitaet auf . Auch entsprach der Zeitpunkt der schwangerschaftsbedingten Besserung und der postpartalen Verschlechterung nicht dem Ansteigen und Abfallen der Kortisol-Plasmawerte . Neuere Forschung hat neuroendokrine Stoerungen bei der RA gezeigt , die ein relatives Versagen der Glukokortikoidregulierung beinhaltet . Die komplexen hormonellen und immunologischen Veraenderungen der Schwangerschaft normalisieren moeglicherweise voruebergehend die neuroendokrinen Stoerungen . Die tatsaechliche Rolle der Glukokortikoide bei der schwangerschaftsbedingten Besserung der RA muss noch geklaert werden ." ], "offsets": [ [ 0, 1268 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Schwangerschaft" ], "offsets": [ [ 29, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 65, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "rheumatoide Arthritis" ], "offsets": [ [ 53, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Schwangerschaft" ], "offsets": [ [ 283, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 354, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Entbindung" ], "offsets": [ [ 397, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011209" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Schwangerschaft" ], "offsets": [ [ 508, 523 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 856, 865 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Schwangerschaft" ], "offsets": [ [ 1052, 1067 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 1164, 1169 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 1174, 1189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-r1-t2.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-r2-t1.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-r3-t1.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-r4-t3.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s3-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii70.ger.abstr-s3-r2-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.0059ii70.ger.abstr-s8-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-passage-0", "type": "abstract", "text": [ "Systemische Symptome werden bei rheumatoider Arthritis ( RA ) zumindest teilweise durch erhoehte IL-6-Spiegel vermittelt . Interleukin-6 ( IL-6) stellt einen potentiellen Ausloeser der menschlichen HPA-Achse dar . Wir haben kuerzlich in einer Studie beobachtet , dass die 24-h-Plasma-ACTH- und -Kortisolspiegel sowie die Spiegel des freien Kortisols im Urin von nicht behandelten Patienten mit RA sich trotz der aktiven Krankheit nicht signifikant von den entsprechenden Spiegeln einer Kontrollgruppe unterschieden . Der morgendliche Peak von Plasma-ACTH- und -Kortisolspiegel wurde jedoch bei RA-Patienten frueher als bei den Kontrollpersonen gemessen . Die Plasma-ACTH- und -Kortisolantwordt auf oCRH waren bei RA-Patienten und den Kontrollgruppen aehnlich . Die Plasma-IL-6-Spiegel zeigten eine verstaerkte zirkadiane Variation und waren bei RA-Patienten im Vergleich zur Kontrollgruppe signifikant erhoeht . Es wurde bei RA-Patienten eine positive zeitliche Korrelation zwischen dem II-6-Plasmaspiegel und dem ACTH-Kortisolspiegel gemessen , wobei der IL-6-Plasmaspiegel dem ACTH eine Stunde und dem Kortisol zwei Stunden vorausging . Bei derselben Patientengruppe beobachteten wir , dass Kortisol mit einer Latenzeit von fuenf Stunden einen negativen Effekt auf IL-6 ausuebte . Bei Patienten mit unbehandelter RA im Anfangsstudium bleibt die gesamte sekretorische Aktivitaet der HPA-Achse \" inadequat \" normal trotz eines erhoehten IL-6-Plasmaspiegels. Endogenes IL-6 stimuliert ACTH- und Kortisolsekretion . Die gemessenen inadequat normalen Kortisolspiegel sind offensichtlich nicht ausreichend , um den Entzuendungsprozess befriedigend zu begrenzen . Bei Patienten mit Sjoegren Syndrom war die ACTH- und Kortisolantwort auf CRH-Stimulation stark erniedrigt . Patienten mit systemischem Lupus erythermatodes zeigten waehrend des Insulintoleranztestes eine erniedrigte Kortisolantwort im Vergleich zu Kontrollpersonen . Diese Ergebnisse zeigen eine direkte und/oder indirekte Beteiligung einer defekten HPA-Achse bei der Pathogenese von manchen pathologischen Syndromen mit Autoimmunbeteiligung ." ], "offsets": [ [ 0, 2102 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 45, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "rheumatoider Arthritis" ], "offsets": [ [ 32, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Interleukin-6" ], "offsets": [ [ 123, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021760" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Urin" ], "offsets": [ [ 353, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 380, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Krankheit" ], "offsets": [ [ 420, 429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "ACTH" ], "offsets": [ [ 1079, 1083 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001655" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Kortisol" ], "offsets": [ [ 1104, 1112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020268" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Patientengruppe" ], "offsets": [ [ 1153, 1168 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Kortisol" ], "offsets": [ [ 1193, 1201 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020268" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "IL-6" ], "offsets": [ [ 1267, 1271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021760" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1287, 1296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "IL-6" ], "offsets": [ [ 1468, 1472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021760" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1663, 1672 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s11-t2", "type": "umlsterm", "text": [ "Syndrom" ], "offsets": [ [ 1686, 1693 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1767, 1776 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "type": "umlsterm", "text": [ "Lupus" ], "offsets": [ [ 1794, 1799 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024131" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "type": "umlsterm", "text": [ "Insulintoleranztestes" ], "offsets": [ [ 1836, 1857 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021641" } ] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s13-t1", "type": "umlsterm", "text": [ "Syndromen" ], "offsets": [ [ 2066, 2075 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s3-r1-t1.1-t3.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s3-r2-t3.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s3-r3-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s7-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s7-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s8-r1-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s8-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s11-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-r2-t3.1-t2.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-r3-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-r4-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t3", "arg2_id": "ZfuerRheumatologie.0059ii75.ger.abstr-s12-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-passage-0", "type": "abstract", "text": [ "Wir untersuchten moegliche Korrelationen der Blutspiegel von Prolactin und verschiedenen Autoantikoerpern , welche beim Lupus erythematodes ( SLE ) auftreten koennen ." ], "offsets": [ [ 0, 167 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Blutspiegel" ], "offsets": [ [ 45, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Prolactin" ], "offsets": [ [ 61, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033371" } ] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Autoantikoerpern" ], "offsets": [ [ 89, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Lupus" ], "offsets": [ [ 120, 125 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024131" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r2-t3.1-t1.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r3-t4.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r5-t3.1-t4.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r6-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r8-t4.1-t1.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r9-t3.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r11-t1.2-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r12-t4.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r13-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r14-t1.2-t4.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-r15-t1.2-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t1", "arg2_id": "ZfuerRheumatologie.0059ii80.ger.abstr-s1-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-passage-0", "type": "abstract", "text": [ "Zwei Drittel aller Patienten mit rheumatoider Arthritis ( RA ) entwickeln im Laufe ihrer Erkrankung radiologisch nachweisbare Erosionen . Glukokortikoide haben kurz- und mittelfristig zunaechst eine schnelle und nachhaltige Wirkung auf die Symptome der Entzuendung . Es werden Daten vorgestellt , welche einen langfristigerer Effekt nahelegen ( laenger als ein Jahr ) . Neuere Studien belegen eindeutig einen retardierenden Effekt auf die Gelenkdestruktion bei RA . Indem man die Kurzzeiteffekte der Entzuendungshemmung von den Langzeitwirkungen auf die Gelenkdestruktion unterscheidet , geben diesen neueren Studien zusaetzlich Einblicke in die der Krankheit zugrundeliegenden pathophysiologischen Prozesse . Die Ergebnisse dieser therapeutischen klinischen Studien unterstuetzen die Sicht , dass Entzuendung und Gelenkdestruktion parallele Prozesse sind , welche durch die dahinter stehenden Ursachen der RA nur lose verbunden sind , sich aber in einem gewissen Umfang unabhaengig voneinander entwickeln . Es ist interessant zu spekulieren , ob diese verschiedenen Effekte der Glukokortikoide sich auf unterschiedliche Mechanismen , dargestellt an anderer Stelle auf diesem Symposion , beziehen koennten ." ], "offsets": [ [ 0, 1207 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 19, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 46, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "radiologisch" ], "offsets": [ [ 100, 112 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "rheumatoider Arthritis" ], "offsets": [ [ 33, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 138, 153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Entzuendung" ], "offsets": [ [ 253, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021368" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Gelenkdestruktion" ], "offsets": [ [ 439, 456 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Kurzzeiteffekte" ], "offsets": [ [ 480, 495 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Langzeitwirkungen" ], "offsets": [ [ 528, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Gelenkdestruktion" ], "offsets": [ [ 554, 571 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Krankheit" ], "offsets": [ [ 650, 659 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Entzuendung" ], "offsets": [ [ 798, 809 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021368" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Gelenkdestruktion" ], "offsets": [ [ 814, 831 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "gewissen" ], "offsets": [ [ 955, 963 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009790" } ] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 1079, 1094 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s1-r1-t4.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s1-r2-t1.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s1-r3-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s2-r1-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s2-r2-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s5-r1-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-r1-t2.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-r2-t1.1-t3.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-r3-t1.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-r4-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-r5-t3.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.0059ii85.ger.abstr-s7-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-passage-0", "type": "abstract", "text": [ "Glukokortikoide koennen eine schwere Osteoporose verursachen und bei Patienten , die ohnehin bereits unter einer entsprechenden Grundkrankheit leiden , zu einer erheblichen Komorbiditaet fuehren . Diese Substanzen interagieren mit dem Kalziummetabolismus auf verschiedenen Ebenen und reduzieren in Osteoblasten vor allem die Synthese bestimmter zentraler Proteine der Knochenmatrix . Weiter erniedrigen sie die Konzentrationen der Sexualhormone vor allem bei Maennern und postmenopausalen Frauen . Glukokortikoide bewirken einen raschen Knochenverlust bereits Wochen nach Therapiebeginn , welcher sich bei chronischer Applikation ueber Jahre fortsetzt . Etwa ein Drittel der Patienten entwickelt Knochenfrakturen , wobei Patienten mit bereits vorher bestehender reduzierter Knochendichte ( insbesondere postmenopausale Frauen ) ein hoeheres Risiko tragen . Das individuelle Frakturrisiko bestimmt sich aus dem Alter des Patienten , seinem Gewicht , der Dauer der Steroideinnahme , der durchschnittlichen Glukokortikoiddosis , sowie der Vorgeschichte in bezug auf Knochendichte und Frakturen . Bei Patienten mit hohem Frakturrisiko kann die Knochendichte erhoeht werden durch Substitution mit Sexualsteroiden ( bei Frauen und Maennern mit nachweisbarem Hormondefizit ) oder durch die Gabe von Bisphosphonaten ( so Etidronat Alendronat , Risedronat ) . , Kalzitriol Kalzitonin und Fluoride , koennen als Zusatzmedikation Verwendung finden , ihr Wirksamkeitsnachweis ist bislang jedoch unbefriedigend . Aerzte , die Patienten unter Langzeittherapie mit Glukokortikoiden fuehren , haben die Verpflichtung , sich ueber den Zustand des Knochens ihrer Patienten Klarheit zu verschaffen und wann immer es erforderlich ist , eine Osteoporoseprophylaxe durchzufuehren ." ], "offsets": [ [ 0, 1759 ] ] } ]

[ { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Osteoporose" ], "offsets": [ [ 37, 48 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 69, 78 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Grundkrankheit" ], "offsets": [ [ 128, 142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Osteoblasten" ], "offsets": [ [ 298, 310 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029418" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Proteine" ], "offsets": [ [ 355, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Knochenmatrix" ], "offsets": [ [ 368, 381 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005962" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Konzentrationen" ], "offsets": [ [ 411, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Maennern" ], "offsets": [ [ 459, 467 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 489, 495 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Glukokortikoide" ], "offsets": [ [ 498, 513 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017710" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Knochenverlust" ], "offsets": [ [ 537, 551 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Therapiebeginn" ], "offsets": [ [ 572, 586 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 675, 684 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Knochenfrakturen" ], "offsets": [ [ 696, 712 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Knochenfrakturen" ], "offsets": [ [ 696, 712 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016658" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 721, 730 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Knochendichte" ], "offsets": [ [ 774, 787 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005938" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 819, 825 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-t7", "type": "umlsterm", "text": [ "Risiko" ], "offsets": [ [ 841, 847 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 920, 929 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Steroideinnahme" ], "offsets": [ [ 963, 978 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Knochendichte" ], "offsets": [ [ 1063, 1076 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005938" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Frakturen" ], "offsets": [ [ 1081, 1090 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016658" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1097, 1106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Knochendichte" ], "offsets": [ [ 1140, 1153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005938" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Sexualsteroiden" ], "offsets": [ [ 1192, 1207 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 1214, 1220 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-t5", "type": "umlsterm", "text": [ "Maennern" ], "offsets": [ [ 1225, 1233 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-t6", "type": "umlsterm", "text": [ "Hormondefizit" ], "offsets": [ [ 1252, 1265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019932" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-t7", "type": "umlsterm", "text": [ "Etidronat" ], "offsets": [ [ 1313, 1322 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086268" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-t8", "type": "umlsterm", "text": [ "Alendronat" ], "offsets": [ [ 1323, 1333 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0102118" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Kalzitonin" ], "offsets": [ [ 1364, 1374 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006668" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Fluoride" ], "offsets": [ [ 1379, 1387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016327" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Verwendung" ], "offsets": [ [ 1419, 1429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Aerzte" ], "offsets": [ [ 1500, 1506 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1513, 1522 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "type": "umlsterm", "text": [ "Langzeittherapie" ], "offsets": [ [ 1529, 1545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "type": "umlsterm", "text": [ "Langzeittherapie" ], "offsets": [ [ 1529, 1545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t5", "type": "umlsterm", "text": [ "Knochens" ], "offsets": [ [ 1630, 1638 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1645, 1654 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "type": "umlsterm", "text": [ "Osteoporoseprophylaxe" ], "offsets": [ [ 1721, 1742 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-r1-t4.1-t3.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-r2-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-r3-t4.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-r4-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-r5-t1.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s1-r6-t2.1-t3.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-r1-t2.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-r2-t3.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-r3-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-r4-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-r5-t1.1-t3.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s2-r6-t2.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s4-r1-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s4-r2-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s4-r3-t1.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r1-t3.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r2-t4.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r3-t6.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r4-t1.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r5-t6.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r6-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r7-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r8-t3.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r9-t3.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r10-t3.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r11-t6.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s5-r12-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-r1-t4.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-r2-t2.1-t4.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-r3-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-r4-t3.1-t2.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s6-r5-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r1-t6.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r2-t7.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r3-t2.1-t6.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r4-t4.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r5-t6.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r6-t3.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r7-t1.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r8-t3.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r9-t2.1-t3.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r10-t7.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r11-t1.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r12-t5.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s7-r13-t2.1-t7.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s8-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s8-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r1-t7.1-t4.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r2-t1.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r3-t1.1-t2.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r4-t2.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r5-t6.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r7-t1.1-t7.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r8-t4.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r9-t4.2-t7.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r10-t6.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r11-t4.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r12-t7.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r13-t7.1-t6.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r14-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r15-t1.1-t6.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r16-t7.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r17-t7.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-r18-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.0059ii97.ger.abstr-s9-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560001.ger.abstr-passage-0", "type": "abstract", "text": [ "Obwohl Arbeitsunfaehigkeit ( AU ) eine direkte Folge der durch die Erkrankung reduzierten Arbeitskraft ist , wurde sie im Fruehstadium der chronischen Polyarthritis ( cP ) kaum untersucht . Deshalb wurden die Haeufigkeit und die Dauer der AU in einer multizentrischen Querschnittsstudie von Patienten im Fruehstadium der cP ( =12 Monate Krankheitsdauer ) im Vergleich zu Pflichtmitgliedern der gesetzlichen Krankenversicherung ermittelt . 134 ambulante erwerbstaetige Patienten erfuellten die Kriterien des American College of Rheumatology fuer die cP von 1987 : 85 Frauen ( 63% von 134 Patienten ) , Alter im Median 50 Jahre . AU wurde entsprechend den Patientenangaben zur Krankschreibung \" \" dokumentiert . Bei der im Median 7 Monate bestehenden Erkrankung trat bisher wenigstens einmal AU wegen cP bei 102 Patienten ( 76% ) auf . Sie bestand bei den Maennern fuer ca. 11 Tage pro Monat , d.h. ca. ein Drittel der Krankheitszeit , und bei den Frauen fuer 8 Tage pro Monat entsprechend ca. einem Viertel der seit Beginn der cP vergangenen Zeit . AU wegen cP dauerte fast fuenfmal laenger als aufgrund der Referenzdaten zu erwarten war . Ueber die \" Krankschreibung \" wegen cP hinaus waren diese Patienten wegen anderer Erkrankungen etwa im gleichen Ausmass wie in die Referenzpopulation arbeitsunfaehig . Der grosse Anteil der von Arbeitsunfaehigkeit wegen cP betroffenen Patienten und die Dauer der AU verdeutlichen das Ausmass gravierender Beeintraechtigungen der Erwerbstaetigkeit bereits im ersten Jahr der cP ." ], "offsets": [ [ 0, 1517 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560001.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 151, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "chronischen Polyarthritis" ], "offsets": [ [ 139, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 291, 300 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Krankenversicherung" ], "offsets": [ [ 407, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021682" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 468, 477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 566, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 587, 596 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patientenangaben" ], "offsets": [ [ 654, 670 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Krankschreibung" ], "offsets": [ [ 675, 690 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 810, 819 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Maennern" ], "offsets": [ [ 854, 862 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 946, 952 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Zeit" ], "offsets": [ [ 1041, 1045 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Krankschreibung" ], "offsets": [ [ 1151, 1166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1197, 1206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Referenzpopulation" ], "offsets": [ [ 1270, 1288 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032659" } ] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1374, 1383 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560001.ger.abstr-s2-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560001.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s3-r1-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s3-r2-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560001.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s3-r3-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560001.ger.abstr-s3-r4-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560001.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560001.ger.abstr-s9-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560008.ger.abstr-passage-0", "type": "abstract", "text": [ "17 Studien ueber die Wirksamkeit der Akupunktur bei Chronischer Polyarthritis ( CP ) , Spondarthropathien ( SPA ) , Lupus erythematodes LE ) , ( lokalisierter und systemischer Sklerodermie ( SD ) wurden bezueglich ihrer Resultate und ihrer wissenschaftlichen Qualitaet durchgesehen . Zur Therapie der CP , der SPA , des LE und der SD kann die Akupunktur zur Zeit nicht empfohlen werden . Die ueberwiegende Mehrheit der durchgesehenen Arbeiten lassen deutliche Maengel erkennen ." ], "offsets": [ [ 0, 478 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Akupunktur" ], "offsets": [ [ 37, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 64, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Lupus" ], "offsets": [ [ 116, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024131" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Sklerodermie" ], "offsets": [ [ 176, 188 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011644" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Chronischer Polyarthritis" ], "offsets": [ [ 52, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "systemischer Sklerodermie" ], "offsets": [ [ 163, 188 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036421" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 288, 296 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Akupunktur" ], "offsets": [ [ 343, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001299" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Zeit" ], "offsets": [ [ 358, 362 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Arbeiten" ], "offsets": [ [ 434, 442 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Maengel" ], "offsets": [ [ 460, 467 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011155" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-r1-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560008.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.70560008.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560008.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.70560008.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560008.ger.abstr-s1-r3-t1.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560008.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.70560008.ger.abstr-s1-t6", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560021.ger.abstr-passage-0", "type": "abstract", "text": [ "Der Einfluss von Meloxicam , einem neuen nichtsteroidalen Antiphlogistikum , auf die spontane Arthrose der Sprunggelenke von Crl : CDBR-Ratten wurde untersucht . Das Medikament war in einer Dosierung von 0,4 , 0,6 und 0,8 mg/kg/Tag ueber einen Zeitraum von 2 Jahren 50 maennlichen und 50 weiblichen Ratten ( pro Dosis ) mit dem Futter appliziert worden . 100 maennliche und 100 weibliche unbehandelte Tiere dienten als Kontrollkollektiv . Histologisch wurden unterschiedliche arthrotische Veraenderungen in Hueft- , Knie- und Sprunggelenken bei behandelten und unbehandelten Tieren beobachtet . Am haeufigsten traten schwere Gelenkveraenderungen in den Sprunggelenken auf . Wesentliche strukturelle Unterschiede zwischen behandelten und unbehandelten Tieren konnten histologisch nicht nachgewiesen werden . Es wird geschlossen , dass Meloxicam in der angewandten Dosierung keinen wesentlichen Einfluss auf die Sprunggelenkarthrose der Ratten ausuebt und damit fuer diese Spezies als chondroneutral zu betrachten ist ." ], "offsets": [ [ 0, 1017 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560021.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arthrose" ], "offsets": [ [ 94, 102 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022408" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Sprunggelenke" ], "offsets": [ [ 107, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003087" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Medikament" ], "offsets": [ [ 166, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "maennlichen" ], "offsets": [ [ 269, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024554" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "weiblichen" ], "offsets": [ [ 288, 298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Ratten" ], "offsets": [ [ 299, 305 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034693" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "maennliche" ], "offsets": [ [ 359, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024554" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "weibliche" ], "offsets": [ [ 378, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015780" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Tiere" ], "offsets": [ [ 401, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Sprunggelenken" ], "offsets": [ [ 526, 540 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003087" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Tieren" ], "offsets": [ [ 575, 581 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Gelenkveraenderungen" ], "offsets": [ [ 625, 645 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Sprunggelenken" ], "offsets": [ [ 653, 667 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003087" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Tieren" ], "offsets": [ [ 751, 757 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Sprunggelenkarthrose" ], "offsets": [ [ 910, 930 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003087" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Sprunggelenkarthrose" ], "offsets": [ [ 910, 930 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022408" } ] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Ratten" ], "offsets": [ [ 935, 941 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034693" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560021.ger.abstr-s1-r1-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s7-r1-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560021.ger.abstr-s7-r2-t2.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.70560021.ger.abstr-s7-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560031.ger.abstr-passage-0", "type": "abstract", "text": [ "Das Behçet-Syndrom charakterisiert das Zusammentreffen von oralen und genitalen Ulzerationen mit okulaeren Laesionen und gilt als vaskulitisches Geschehen . Wegen der Seltenheit des Syndroms stuetzen sich therapeutische Richtlinien heute noch auf kleinere Fallzahlen oder Kasuistiken . Ein betraechtliches Letalitaetsrisiko bei M. Behçet stellt die ZNS-Beteiligung dar , manifest als nekrotisierende Meningo-Enzephalitis des Hirnstamms , der Capsula interna oder der Basalganglien ." ], "offsets": [ [ 0, 482 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560031.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Syndroms" ], "offsets": [ [ 182, 190 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.70560031.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Hirnstamms" ], "offsets": [ [ 425, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006121" } ] }, { "id": "ZfuerRheumatologie.70560031.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Hirnstamms" ], "offsets": [ [ 425, 435 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.70560031.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Basalganglien" ], "offsets": [ [ 467, 480 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004781" } ] }, { "id": "ZfuerRheumatologie.70560031.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Capsula interna" ], "offsets": [ [ 442, 457 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0152341" } ] } ]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.70560053.ger.abstr-passage-0", "type": "abstract", "text": [ "Der Nachweis von anti-Doppelstrang-DNS-Antikoerpern ( dsDNA-Ak ) , ein Kriterium des American College of Rheumatology ( ACR ) zur Diagnostik des Systemischen Lupus erythematodes SLE ) , ( stellt insbesondere bei aktiven Verlaufsformen , bei klinischer Einordnung und Beachtung der ACR-Kriterien ein hervorragendes Instrument in der Hand des Klinikers dar . Kommerzielle ELISA-Testsysteme sind sehr vorteilhaft bei der routinemaessigen Bestimmung einer grossen Anzahl von Seren , weisen jedoch haeufig nicht-SLE-spezifische Antikoerper nach und geben daher falsch positive Ergebnisse ." ], "offsets": [ [ 0, 584 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Diagnostik" ], "offsets": [ [ 130, 140 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" } ] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Lupus" ], "offsets": [ [ 158, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024131" } ] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Instrument" ], "offsets": [ [ 314, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Hand" ], "offsets": [ [ 332, 336 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Systemischen Lupus erythematodes" ], "offsets": [ [ 145, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024141" } ] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Antikoerper" ], "offsets": [ [ 523, 534 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-r1-t1.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560053.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-r2-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.70560053.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-r3-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560053.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-r4-t1.1-t3.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.70560053.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-r5-t5.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.70560053.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-r6-t3.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-r7-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560053.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560053.ger.abstr-s1-r8-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560053.ger.abstr-s1-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560063.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Diagnostik vieler rheumatischer Systemerkrankungen wird heute durch den Nachweis von Autoantikoerpern unterstuetzt und erleichtert . Fuer die Serodiagnostik der Rheumatoiden Arthritis ( RA ) stehen nur die doch wenig spezifischen Rheumafaktoren zur Verfuegung . Mit dem Ziel , neue krankheitsspezifische Autoantikoerper nachzuweisen , erfolgte eine besondere Proteinaufarbeitung aus Synovialisbiopsien und anderen Geweben . Western Blots der gewonnenen Proteine wurden eingesetzt , um Seren von RA-Patienten und solchen mit anderen rheumatischen Erkrankungen zu untersuchen . Die signifikanteste Immunreaktion von RA-Patienten richtete sich gegen ein 68k-Antigen, welches vermutlich ubiquitaer exprimiert wird , da es nicht nur in Synovialis , sondern in allen weiteren untersuchten Humangeweben und HeLa-Zellen nachgewiesen werden konnte . Der isoelektrische Punkt liegt bei 5,1 , das Protein ist O-glykosyliert und im endoplasmatischen Retikulum und/oder Cytoplasma lokalisiert . Antikoerper gegen dieses 68k-Antigen waren bei 110 von 167 RA-Patienten nachzuweisen , was einer Sensitivitaet von 66% entspricht . Ihr Vorkommen war unabhaengig vom Rheumafaktornachweis , da sie auch bei 7 von 12 seronegativen RA-Patienten zu finden waren , dagegen nur bei einem Patienten aus einer Kontrollgruppe von 98 Patienten mit anderen rheumatologischen Krankheitsbildern , bei einem von 22 HIV-Patienten und ueberhaupt nicht bei 55 Gesunden . Daraus resultiert eine RA-Spezifitaet fuer diesen Antikoerper von 99% . Wegen der auffaelligen Krankheitsspezifitaet der anti-68k-Antikoerper liegt es nahe , nach korrespondierenden autoreaktiven T-Zellen zu suchen , um die Rolle dieser neuen Autoreaktivitaet in dem Pathomechanismus der RA zu analysieren ." ], "offsets": [ [ 0, 1746 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560063.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Diagnostik" ], "offsets": [ [ 4, 14 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Autoantikoerpern" ], "offsets": [ [ 89, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Serodiagnostik" ], "offsets": [ [ 146, 160 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600324" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 178, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Rheumafaktoren" ], "offsets": [ [ 234, 248 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035448" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Rheumatoiden Arthritis" ], "offsets": [ [ 165, 187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Autoantikoerper" ], "offsets": [ [ 308, 323 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004358" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Proteinaufarbeitung" ], "offsets": [ [ 363, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Geweben" ], "offsets": [ [ 418, 425 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Proteine" ], "offsets": [ [ 457, 465 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Synovialis" ], "offsets": [ [ 735, 745 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039099" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Humangeweben" ], "offsets": [ [ 787, 799 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040300" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Protein" ], "offsets": [ [ 890, 897 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Retikulum" ], "offsets": [ [ 942, 951 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035295" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Antikoerper" ], "offsets": [ [ 986, 997 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1267, 1276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1309, 1318 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Antikoerper" ], "offsets": [ [ 1489, 1500 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "T-Zellen" ], "offsets": [ [ 1635, 1643 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039194" } ] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 1663, 1668 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560063.ger.abstr-s1-r1-t1.1-t2.1", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r1-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r2-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r3-t1.1-t3.1", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r4-t3.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r5-t3.1-t1.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r6-t4.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r7-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r8-t3.1-t4.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s2-r9-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-r2-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-r3-t1.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-r4-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-r5-t2.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s3-r6-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s5-r1-t1.1-t2.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s5-r2-t2.1-t1.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s6-r1-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560063.ger.abstr-s6-r2-t1.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.70560063.ger.abstr-s10-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560071.ger.abstr-passage-0", "type": "abstract", "text": [ "Zielsetzung Bestehen Zusammenhaenge zwischen Helicobacter-pylori-induzierten und NSAR-induzierten gastrointestinalen Schleimhautlaesionen und resultiert daraus ein erhoehtes Risiko ? Welche diagnostischen und therapeutischen Konsequenzen sind zu ziehen ?" ], "offsets": [ [ 0, 254 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560071.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Schleimhautlaesionen" ], "offsets": [ [ 117, 137 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026724" } ] }, { "id": "ZfuerRheumatologie.70560071.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Risiko" ], "offsets": [ [ 174, 180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035647" } ] } ]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.70560080.ger.abstr-passage-0", "type": "abstract", "text": [ "Mit Hilfe von Musterpatienten \" paper patients \" verglichen wir die Therapieprinzipien von Hausaerzten und Rheumatologen bei rheumatoider Arthritis und Gonarthrose . Unsere Umfrage bestand aus drei Fallbeispielen mit verschiedenen Schweregraden der rheumatoiden Arthritis ( RA ) und einem Fall einer Gonarthrose . Von randomisiert ausgewaehlten 252 Hausaerzten antworteten 111 und von 132 Rheumatologen 78 Kollegen . Wir stellten fest , dass Rheumatologen bei der Therapie von RA vermehrt nichtsteroidale Antirheumatika ( NSAR Basistherapeutika , Steroide und physikalische Therapie ) , einsetzten ." ], "offsets": [ [ 0, 599 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Musterpatienten" ], "offsets": [ [ 14, 29 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Therapieprinzipien" ], "offsets": [ [ 68, 86 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Hausaerzten" ], "offsets": [ [ 91, 102 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031835" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 138, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Gonarthrose" ], "offsets": [ [ 152, 163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0409959" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "rheumatoider Arthritis" ], "offsets": [ [ 125, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 262, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Gonarthrose" ], "offsets": [ [ 300, 311 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0409959" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 249, 271 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Hausaerzten" ], "offsets": [ [ 349, 360 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031835" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 464, 472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Antirheumatika" ], "offsets": [ [ 505, 519 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003191" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Steroide" ], "offsets": [ [ 547, 555 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 574, 582 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "physikalische Therapie" ], "offsets": [ [ 560, 582 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031818" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r1-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r2-t2.2-t5.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r3-t2.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r4-t5.1-t2.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r5-t2.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r6-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r7-t6.1-t2.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r8-t2.2-t4.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r9-t5.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r10-t1.1-t2.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r11-t4.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r12-t2.2-t1.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r13-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r14-t5.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r15-t6.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r16-t2.2-t6.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r17-t6.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r18-t2.2-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r19-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s1-r20-t4.1-t2.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-r1-t3.1-t1.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-r2-t4.2-t1.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-r3-t4.1-t1.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-r5-t1.1-t4.2", "type": "method_of", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-r6-t1.2-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-r7-t1.2-t4.2", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560080.ger.abstr-s4-r9-t3.1-t4.2", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.70560080.ger.abstr-s4-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560089.ger.abstr-passage-0", "type": "abstract", "text": [ "Eine 56jaehrige Patientin mit chronischer Polyarthritis und histologisch verifizierter Vaskulitis mit Nagelfalznekrosen und Fingerendgliedgangraen an beiden Haenden sowie Hautulzera an beiden Unterschenkeln wurde ueber 16 Wochen mit Cyclosporin A , Prednisolon und Alprostadil behandelt ." ], "offsets": [ [ 0, 288 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 42, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Vaskulitis" ], "offsets": [ [ 87, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042384" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Nagelfalznekrosen" ], "offsets": [ [ 102, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027342" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Nagelfalznekrosen" ], "offsets": [ [ 102, 119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Fingerendgliedgangraen" ], "offsets": [ [ 124, 146 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017086" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Haenden" ], "offsets": [ [ 157, 164 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "type": "umlsterm", "text": [ "Cyclosporin" ], "offsets": [ [ 233, 244 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010592" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "type": "umlsterm", "text": [ "Prednisolon" ], "offsets": [ [ 249, 260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032950" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "type": "umlsterm", "text": [ "Alprostadil" ], "offsets": [ [ 265, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002335" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "type": "umlsterm", "text": [ "chronischer Polyarthritis" ], "offsets": [ [ 30, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "type": "umlsterm", "text": [ "Cyclosporin A" ], "offsets": [ [ 233, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010592" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r1-t6.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r2-t3.1-t4.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r3-t3.1-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r4-t8.1-t9.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r5-t7.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r6-t6.1-t10.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r7-t3.1-t9.1", "type": "consists_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r8-t4.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r9-t8.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r10-t8.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r11-t9.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r12-t4.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r13-t3.1-t8.1", "type": "consists_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r14-t7.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r15-t7.1-t10.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r16-t3.1-t11.1", "type": "consists_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r17-t8.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r18-t3.1-t7.1", "type": "consists_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r19-t9.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r20-t9.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r21-t3.1-t5.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r22-t9.1-t10.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r23-t11.1-t8.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r24-t6.1-t9.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r25-t7.1-t8.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r26-t1.1-t10.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r27-t7.1-t11.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r28-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r29-t6.1-t8.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r30-t3.1-t6.1", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r31-t6.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r32-t11.1-t10.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r33-t6.1-t11.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r34-t6.1-t3.1", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r35-t4.1-t10.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r36-t4.1-t5.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r37-t6.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r38-t7.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r39-t8.1-t11.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r40-t6.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r41-t9.1-t8.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r42-t8.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r43-t3.1-t10.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r44-t9.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r45-t11.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r46-t8.1-t10.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r47-t11.1-t9.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r48-t9.1-t11.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r49-t7.1-t9.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r50-t1.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r51-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t1", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r52-t11.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560089.ger.abstr-s1-r53-t11.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t11", "arg2_id": "ZfuerRheumatologie.70560089.ger.abstr-s1-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560105.ger.abstr-passage-0", "type": "abstract", "text": [ "Vaskulitiden sind seltene meist systemische entzuendliche Erkrankungen , , die das Gefaesssystem in unterschiedlichem Ausmass und Verteilungsmuster betreffen . Primaere aetiologisch ungeklaerte und sekundaere , , auf andere Ursachen ( Infektionen Medikamente , Tumoren ) , zurueckfuehrbare Formen muessen unterschieden werden . Die Panarteriitis nodosa bei der chronischen Hepatitis B und die gemischte Kryoglobulinaemie bei der Hepatitis C sind klassische Beispiele fuer durch Infektionen induzierte Vaskulitiden . Bei der Vielzahl an Patienten mit chronischen Virushepatitiden stellt die Entwicklung einer Vaskulitis jedoch eine seltene Komplikation dar . Auch bei der HIV-Infektion kommen Vaskilitiden vor , was durch haeufige und chronische opportunistische Infektionen oder Defekte in der Immunregulation erklaert werden kann . Daneben sind in Einzelberichten oder kleinen Serien eine Vielzahl von teils sehr verbreiteten Erregern als Verursacher von Vaskulitiden beschrieben worden , entweder durch direkte Infektion des Endothels oder durch die Induktion eines immunologischen Prozesses , der zur Gefaessschaedigung fuehrt . Es wird postuliert , dass bei jenen Patienten , die durch immunologische Mechanismen ausgeloeste Vaskulitiden bei Infektionen entwickeln , eine praedisponierende Reaktionsweise des Immunsystems vorliegt . Nach erfolgreicher Behandlung der Infektion bessert sich in der Regel die Vaskulitis . Da somit eine kausale Therapie moeglich ist , sollte bei jeder Vaskulitis auch nach einer zugrunde liegenden Infektion gesucht werden ." ], "offsets": [ [ 0, 1559 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560105.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Infektionen" ], "offsets": [ [ 235, 246 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Medikamente" ], "offsets": [ [ 247, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Tumoren" ], "offsets": [ [ 261, 268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Hepatitis" ], "offsets": [ [ 373, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019158" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Kryoglobulinaemie" ], "offsets": [ [ 403, 420 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010403" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Hepatitis" ], "offsets": [ [ 429, 438 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019158" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Infektionen" ], "offsets": [ [ 478, 489 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t5", "type": "umlsterm", "text": [ "Panarteriitis nodosa" ], "offsets": [ [ 332, 352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031036" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t6", "type": "umlsterm", "text": [ "chronischen Hepatitis" ], "offsets": [ [ 361, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019189" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t7", "type": "umlsterm", "text": [ "Hepatitis B" ], "offsets": [ [ 373, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019163" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t8", "type": "umlsterm", "text": [ "Hepatitis C" ], "offsets": [ [ 429, 440 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019196" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s3-t9", "type": "umlsterm", "text": [ "chronischen Hepatitis B" ], "offsets": [ [ 361, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0524909" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 536, 545 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Vaskulitis" ], "offsets": [ [ 608, 618 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042384" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Komplikation" ], "offsets": [ [ 639, 651 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "HIV-Infektion" ], "offsets": [ [ 671, 684 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019693" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Infektionen" ], "offsets": [ [ 762, 773 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "opportunistische Infektionen" ], "offsets": [ [ 745, 773 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029118" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Infektion" ], "offsets": [ [ 1013, 1022 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Endothels" ], "offsets": [ [ 1027, 1036 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014257" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1168, 1177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Infektionen" ], "offsets": [ [ 1246, 1257 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Immunsystems" ], "offsets": [ [ 1313, 1325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020962" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 1356, 1366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Infektion" ], "offsets": [ [ 1371, 1380 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Vaskulitis" ], "offsets": [ [ 1411, 1421 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042384" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 1446, 1454 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Vaskulitis" ], "offsets": [ [ 1487, 1497 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042384" } ] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "type": "umlsterm", "text": [ "Infektion" ], "offsets": [ [ 1533, 1542 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560105.ger.abstr-s2-r1-t1.1-t3.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s2-r2-t2.1-t1.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s2-r3-t2.1-t3.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s2-r4-t3.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-r1-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-r2-t2.1-t3.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-r3-t3.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-r4-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-r5-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s4-r6-t3.1-t2.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s6-r1-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s6-r2-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s7-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-r1-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-r2-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-r3-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-r4-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-r5-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s8-r6-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s9-r2-t3.1-t1.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s9-r4-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s9-r5-t1.2-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560105.ger.abstr-s9-r6-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560105.ger.abstr-s9-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560114.ger.abstr-passage-0", "type": "abstract", "text": [ "Da die monotherapeutischen Behandlungsverfahren der chronischen Polyarthritis noch nicht ihren Anspruechen genuegen , wird vielerorts an Strategien zur Kombination der in Frage kommenden Einzelsubstanzen gearbeitet . Im Anschluss an eine vor zwei Jahren erstellte Literaturuebersicht fasst die nachstehende Arbeit vor allem die in den Jahrgaengen 1995 und 1996 erschienenen Publikationen zusammen . Die meisten Studien gruppieren sich um MTX , fuer das in Zweifachkombination mit Chloroquin ( -derivaten Cyclosporin oder Sulfasalazin ) , guenstige Ergebnisse berichtet wurden . Insbesondere erscheint die Dreifachkombination von Methotrexat mit Hydroxychloroquin und Azathioprin erfolgversprechend zu sein , auch wenn die vorliegenden Studien wegen methodischer Unschaerfen noch keine abschliessende Wertung zulassen . Fuer die Kombination von Sulfasalazin mit intramuskulaerem Gold , von Sulfasalazin mit Methotrexat und Hydroxychloroquin sowie von Methotrexat mit intramuskulaerem Gold reicht die Datenlage fuer eine Beurteilung bei weitem noch nicht aus ." ], "offsets": [ [ 0, 1058 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560114.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 64, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "chronischen Polyarthritis" ], "offsets": [ [ 52, 77 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Literaturuebersicht" ], "offsets": [ [ 264, 283 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Arbeit" ], "offsets": [ [ 307, 313 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Publikationen" ], "offsets": [ [ 374, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Cyclosporin" ], "offsets": [ [ 504, 515 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010592" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Sulfasalazin" ], "offsets": [ [ 521, 533 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036078" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Methotrexat" ], "offsets": [ [ 629, 640 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025677" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Hydroxychloroquin" ], "offsets": [ [ 645, 662 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020336" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Azathioprin" ], "offsets": [ [ 667, 678 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004482" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Sulfasalazin" ], "offsets": [ [ 844, 856 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036078" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Gold" ], "offsets": [ [ 878, 882 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018026" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Sulfasalazin" ], "offsets": [ [ 889, 901 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036078" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Methotrexat" ], "offsets": [ [ 906, 917 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025677" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Hydroxychloroquin" ], "offsets": [ [ 922, 939 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020336" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "Methotrexat" ], "offsets": [ [ 950, 961 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025677" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "type": "umlsterm", "text": [ "Gold" ], "offsets": [ [ 983, 987 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018026" } ] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t8", "type": "umlsterm", "text": [ "Beurteilung" ], "offsets": [ [ 1019, 1030 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560114.ger.abstr-s3-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s3-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-r3-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-r4-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-r5-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s4-r6-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r1-t8.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t8", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r2-t7.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r3-t7.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r4-t7.1-t8.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r5-t7.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r6-t7.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r7-t2.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r8-t7.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r9-t2.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r10-t7.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r11-t2.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r12-t8.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t8", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r13-t2.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r14-t2.1-t8.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r15-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560114.ger.abstr-s5-r16-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.70560114.ger.abstr-s5-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560127.ger.abstr-passage-0", "type": "abstract", "text": [ "Ziel der Arbeit : Entwicklung und Evaluation einer Modifikation der Larsen-Methode zur quantitativen Beschreibung des roentgenologischen Verlaufs der chronischen Polyarthritis mit dem Ziel einer eindeutigen verbalen Definition der verschiedenen Stadien und einer besseren Korrelation der numerischen Skala mit dem Ausmass der Gelenkdestruktion . Beschreibung der Methode : Waehrend die in Europa haeufig verwendete Original-Larsen-Methode im wesentlichen auf dem Vergleich der Roentgenbilder mit Standardreferenzfilmen bei nur vager verbaler Definition beruht , werden in der Modifikation die verschiedenen Stadien auch verbal durch semiquantitative Angabe des Ausmasses der Destruktion der Gelenkoberflaeche definiert : das StadiumI ist durch Weichteilschwellung und ggf. gelenknahe Osteoporose bzw. auch Gelenkspaltverschmaelerung charakterisiert und bleibt damit gegenueber der Originalmethode unveraendert ; das Stadium II entspricht einer Destruktion der Gelenkoberflaeche bis zu 25% der gesamten Gelenkoberflaeche , im StadiumIII sind 26-50% , im Stadium IV 51-75% und im StadiumV ueber 75% der Gelenkoberflaeche destruiert . 32 Gelenke der Haende und Vorfuesse werden bewertet , so dass sich ein Gesamtscore von 0-160 ergibt . Bespiele fuer die verschiedenen Stadien im Sinne von Standardreferenzfilmen fuer die Fingergrund- , Fingermittel- und Handgelenke sowie die Zehengrundgelenke werden gezeigt . Evaluation der Methode : Standard-ap-Aufnahmen der Haende und Vorfuesse von 24 Patienten mit frueher erosiver chronischer Polyarthritis ( c.P. ) zum Zeitpunkt 0 ( T0) und nach 36 Monaten ( T1) wurden von zwei Untersuchern ( G.H. und R.R. ) bewertet . Der Unterschied der Bewertung zwischen den beiden Untersuchern ( Inter-Observer-Differenz ) wurde mit dem Unterschied zwischen den beiden Zeitpunkten ( T0 und T1) beim gleichen Patienten ( Intra-Patienten-Differenz ) mittels einer hierarchischen Varianzanalyse ( ANOVA ) verglichen . Dabei erwies sich die Intrapatientenvarianz ( von T0 nach T1) als 8 mal groesser als die Varianz zwischen den Untersuchern . Der mit der Methode gefundene Unterschied zwischen beiden Beobachtungszeitpunkten ist also real und nicht durch Unsicherheit bei der Bewertung bedingt . - Zusaetzlich wurde die Methode bei Patienten einer zweijaehrigen Basistherapiestudie mit Roentgenaufnahmen zu Therapiebeginn sowie nach 6 , 12 und 24 Monaten angewandt . Dabei konnte eine Verzoegerung der radiologischen Progression nach dem sechsten Monat durch parenterales Gold und Methotrexat demonstriert werden . Schlussfolgerung : Die Modifikation der Larsen-Methode erweist sich als zuverlaessiges Mass zur Beschreibung des radiologischen Verlaufs der chronischen Polyarthritis . Weitere Verbesserungsmoeglichkeiten der Methode werden diskutiert ." ], "offsets": [ [ 0, 2777 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arbeit" ], "offsets": [ [ 9, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 162, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Gelenkdestruktion" ], "offsets": [ [ 326, 343 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "chronischen Polyarthritis" ], "offsets": [ [ 150, 175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Methode" ], "offsets": [ [ 363, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Europa" ], "offsets": [ [ 389, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015176" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Standardreferenzfilmen" ], "offsets": [ [ 496, 518 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Standardreferenzfilmen" ], "offsets": [ [ 496, 518 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026601" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Gelenkoberflaeche" ], "offsets": [ [ 691, 708 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "gelenknahe" ], "offsets": [ [ 773, 783 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t7", "type": "umlsterm", "text": [ "Osteoporose" ], "offsets": [ [ 784, 795 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t8", "type": "umlsterm", "text": [ "Originalmethode" ], "offsets": [ [ 881, 896 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t9", "type": "umlsterm", "text": [ "Gelenkoberflaeche" ], "offsets": [ [ 960, 977 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t10", "type": "umlsterm", "text": [ "Gelenkoberflaeche" ], "offsets": [ [ 1002, 1019 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t11", "type": "umlsterm", "text": [ "Gelenkoberflaeche" ], "offsets": [ [ 1101, 1118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 1135, 1142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Haende" ], "offsets": [ [ 1147, 1153 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Standardreferenzfilmen" ], "offsets": [ [ 1287, 1309 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Standardreferenzfilmen" ], "offsets": [ [ 1287, 1309 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026601" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Fingergrund-" ], "offsets": [ [ 1319, 1331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016129" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Fingermittel-" ], "offsets": [ [ 1334, 1347 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016129" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "Handgelenke" ], "offsets": [ [ 1352, 1363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043265" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t6", "type": "umlsterm", "text": [ "Zehengrundgelenke" ], "offsets": [ [ 1374, 1391 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040357" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "type": "umlsterm", "text": [ "Zehengrundgelenke" ], "offsets": [ [ 1374, 1391 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Methode" ], "offsets": [ [ 1424, 1431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Haende" ], "offsets": [ [ 1460, 1466 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1488, 1497 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 1531, 1544 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "chronischer Polyarthritis" ], "offsets": [ [ 1519, 1544 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1837, 1846 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Varianzanalyse" ], "offsets": [ [ 1906, 1920 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002780" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Varianzanalyse" ], "offsets": [ [ 1906, 1920 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "ANOVA" ], "offsets": [ [ 1923, 1928 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002780" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Methode" ], "offsets": [ [ 2081, 2088 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Methode" ], "offsets": [ [ 2246, 2253 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 2258, 2267 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t3", "type": "umlsterm", "text": [ "Basistherapiestudie" ], "offsets": [ [ 2288, 2307 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t4", "type": "umlsterm", "text": [ "Roentgenaufnahmen" ], "offsets": [ [ 2312, 2329 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043299" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "type": "umlsterm", "text": [ "Therapiebeginn" ], "offsets": [ [ 2333, 2347 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Verzoegerung" ], "offsets": [ [ 2411, 2423 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011100" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "radiologischen" ], "offsets": [ [ 2428, 2442 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t3", "type": "umlsterm", "text": [ "Gold" ], "offsets": [ [ 2498, 2502 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018026" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "type": "umlsterm", "text": [ "Methotrexat" ], "offsets": [ [ 2507, 2518 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025677" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "radiologischen" ], "offsets": [ [ 2654, 2668 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t2", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 2694, 2707 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "type": "umlsterm", "text": [ "chronischen Polyarthritis" ], "offsets": [ [ 2682, 2707 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "type": "umlsterm", "text": [ "Methode" ], "offsets": [ [ 2750, 2757 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-r1-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-r2-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-r3-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t2", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-r4-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t2", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s1-r5-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-r1-t8.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t8", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-r2-t7.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-r3-t1.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-r4-t7.1-t8.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s2-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-r5-t1.2-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s2-r6-t7.1-t1.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s3-r1-t1.1-t2.1", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s3-r2-t2.1-t1.1", "type": "interconnects", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t2", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r1-t3.1-t5.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r2-t7.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r3-t3.1-t7.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r4-t5.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r5-t6.1-t5.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t6", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r6-t7.1-t6.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r7-t4.1-t5.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r8-t5.1-t6.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r9-t7.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r10-t6.1-t7.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t6", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r11-t5.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s4-r12-t4.1-t7.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s4-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-r1-t4.1-t3.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-r2-t1.2-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-r3-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-r4-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-r5-t3.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s5-r6-t3.1-t1.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s6-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s6-r2-t1.1-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s6-r3-t3.1-t2.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r1-t1.2-t3.2", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r2-t1.2-t3.2", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r3-t1.1-t3.2", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r4-t3.1-t1.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r5-t3.2-t1.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r6-t3.2-t1.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r8-t1.2-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r9-t3.2-t5.1", "type": "precedes", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r10-t5.1-t1.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r11-t1.2-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s9-r12-t3.2-t3.1", "type": "precedes", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s10-r1-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s10-r2-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s10-r3-t4.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s12-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560127.ger.abstr-s10-r4-t4.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560127.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.70560127.ger.abstr-s11-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560136.ger.abstr-passage-0", "type": "abstract", "text": [ "27 Patienten mit sternocostoclaviculaerer Hyperostose ( SCCH ) und/oder Pustuloeser Arthroosteitis ( PAO ) wurden knochenszintigraphisch und konventionell-radiologisch sowie mit anderen radiologischen Methoden ( CT , MRT ) untersucht . 25 der 27 Patienten mit SCCH zeigten eine charakteristische Mehrbelegung der sternocostoclaviculaeren Region in Form eines Stierkopfes \" . \" Dabei repraesentiert das Manubrium sterni den Kopf und die entzuendeten sternoclaviculaeren Gelenke und die angrenzenden Klavikeln die Hoerner dieses Stierkopfes \" . \" Bei 19 von 27 Patienten mit SCCH zeigte die Sklettszintigraphie zusaetzliche Manifestationen ( Spondylitis Sakroiliitis , Ostitis/Periostitis ) . , Wenn die Patienten eine Pustulosis Palmoplantaris ( PPP ) und/oder eine Psoriasis haben , erlaubt das szintigraphische \" Stierhorn-Zeichen \" die Diagnose der PAO ( 19 Patienten ) mit groesster Sicherheit . Patienten mit SCCH ohne Hauterkrankung zur Zeit der Diagnosestellung ( 8 von 27 Patienten ) klassifizierten wir als inkomplette PAO , da sie im spaeteren Verlauf der Erkrankung Hautmanifestationen entwickeln koennen ." ], "offsets": [ [ 0, 1116 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 3, 12 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Hyperostose" ], "offsets": [ [ 42, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020492" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "knochenszintigraphisch" ], "offsets": [ [ 114, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "konventionell-radiologisch" ], "offsets": [ [ 141, 167 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "radiologischen" ], "offsets": [ [ 186, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Methoden" ], "offsets": [ [ 201, 209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 246, 255 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Stierkopfes" ], "offsets": [ [ 359, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Kopf" ], "offsets": [ [ 423, 427 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 469, 476 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Hoerner" ], "offsets": [ [ 512, 519 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019939" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Stierkopfes" ], "offsets": [ [ 527, 538 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018670" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 559, 568 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Spondylitis" ], "offsets": [ [ 640, 651 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038012" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 702, 711 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Psoriasis" ], "offsets": [ [ 765, 774 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033860" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Stierhorn-Zeichen" ], "offsets": [ [ 814, 831 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019939" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Diagnose" ], "offsets": [ [ 838, 846 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 860, 869 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "Sicherheit" ], "offsets": [ [ 886, 896 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036043" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 899, 908 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Hauterkrankung" ], "offsets": [ [ 923, 937 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Zeit" ], "offsets": [ [ 942, 946 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Diagnosestellung" ], "offsets": [ [ 951, 967 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t5", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 979, 988 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t6", "type": "umlsterm", "text": [ "Hautmanifestationen" ], "offsets": [ [ 1076, 1095 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037285" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r2-t2.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r3-t1.1-t4.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r4-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r5-t6.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r6-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r7-t1.1-t5.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r8-t1.1-t6.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s1-r9-t1.1-t6.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r1-t1.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r2-t2.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r3-t2.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r4-t4.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r5-t3.1-t2.1", "type": "interconnects", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r6-t1.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r7-t3.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r8-t3.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r9-t2.1-t3.1", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s3-r10-t4.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s4-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-r1-t2.1-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-r2-t6.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-r3-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-r4-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s5-r5-t2.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s6-r1-t2.1-t4.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560136.ger.abstr-s6-r2-t6.1-t2.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.70560136.ger.abstr-s6-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560156.ger.abstr-passage-0", "type": "abstract", "text": [ "Nach neuen epidemiologischen Untersuchungsergebnissen ist die genetische Haemochromatose eine der haeufigsten genetisch determinierten Stoffwechselerkrankungen in der kaukasischen Population . Die lebenslang waehrende Eisenueberladung fuehrt bei mehr als der Haelfte der Patienten zu einer teilweise schweren Arthropathie . Die haemochromatotische Arthropathie wird haeufig als Arthrose oder Rheumatoide Arthritis fehlgedeutet , obwohl sie einige recht typische Besonderheiten aufweist . Bei ca. 5000 Patienten , die in die Rheumasprechstunden der Kliniken Bad Nauheim und Frankfurt wegen unterschiedlichster rheumatologischer Diagnosen ueberwiesen wurden , konnten bislang 11 Patienten mit manifester Haemochromatose aufgrund des typischen Gelenkbefalls entdeckt werden . In allen Faellen fanden sich bereits ausgepraegte Organschaedigungen , so dass die Lebenserwartung dieser Patienten eingeschraenkt ist . Diese Untersuchung zeigt , dass die genetische Haemochromatose eine haeufig uebersehene Erkrankung ist . Die Kenntnis des Befallsmusters kann zur fruehen Diagnose einer genetischen Haemochromatose fuehren und somit Organschaeden vermeiden ." ], "offsets": [ [ 0, 1150 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560156.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Haemochromatose" ], "offsets": [ [ 73, 88 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018995" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Stoffwechselerkrankungen" ], "offsets": [ [ 135, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025519" }, { "db_name": "UMLS", "db_id": "C0025520" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Population" ], "offsets": [ [ 180, 190 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032659" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Eisenueberladung" ], "offsets": [ [ 218, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022084" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 271, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Arthrose" ], "offsets": [ [ 378, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022408" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 404, 413 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Rheumatoide Arthritis" ], "offsets": [ [ 392, 413 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 501, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Bad" ], "offsets": [ [ 557, 560 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0150141" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Diagnosen" ], "offsets": [ [ 627, 636 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 677, 686 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "Haemochromatose" ], "offsets": [ [ 702, 717 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018995" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t6", "type": "umlsterm", "text": [ "Gelenkbefalls" ], "offsets": [ [ 741, 754 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Lebenserwartung" ], "offsets": [ [ 856, 871 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023671" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 879, 888 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Haemochromatose" ], "offsets": [ [ 957, 972 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018995" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Diagnose" ], "offsets": [ [ 1064, 1072 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Haemochromatose" ], "offsets": [ [ 1091, 1106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018995" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560156.ger.abstr-s1-r1-t2.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s1-r2-t1.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s1-r3-t2.2-t2.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r2-t2.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r3-t5.1-t3.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r4-t5.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r5-t2.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r6-t6.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t6", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r7-t5.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r8-t3.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r9-t6.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s4-t6", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s4-r10-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560156.ger.abstr-s5-r1-t1.1-t2.1", "type": "property_of", "arg1_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.70560156.ger.abstr-s7-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560173.ger.abstr-passage-0", "type": "abstract", "text": [ "Autologe und allogene Stammzelltransplantationen werden heute intensiv diskutiert als moegliche Behandlung fuer Patienten mit schweren Autoimmunkrankheiten . Tierexperimentelle Daten und Fallberichte von Patienten mit gebesserter Autoimmunkrankheit nach Stammzelltransplantation wegen einer anderen Erkrankung unterstuetzen dieses Konzept . Um moeglichst bald klare Antworten auf die vielen offenen Fragen zu erhalten , haben die Europaeische Liga gegen Rheumatismus EULAR und die Europaeische Gruppe fuer Blut- und Knochenmarktransplantation EBMT gemeinsam Richtlinien fuer ein gezieltes Vorgehen erarbeitet . Sie werden hier vorgestellt . Klare Daten fehlen zur Zeit . Die noch vereinzelten Fallberichte sehen vielversprechend aus und erste Studien sind in Vorbereitung . In wenigen Jahren sollte es bei koordiniertem Vorgehen moeglich sein , den Stellenwert dieser Behandlungsmethode beurteilen zu koennen ." ], "offsets": [ [ 0, 910 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560173.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 96, 106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 112, 121 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Autoimmunkrankheiten" ], "offsets": [ [ 135, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004364" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Tierexperimentelle" ], "offsets": [ [ 158, 176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003043" }, { "db_name": "UMLS", "db_id": "C0003062" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Fallberichte" ], "offsets": [ [ 187, 199 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007320" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 204, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Stammzelltransplantation" ], "offsets": [ [ 254, 278 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242603" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Rheumatismus" ], "offsets": [ [ 454, 466 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035435" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Blut-" ], "offsets": [ [ 506, 511 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Knochenmarktransplantation" ], "offsets": [ [ 516, 542 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005961" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Knochenmarktransplantation" ], "offsets": [ [ 516, 542 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005953" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t5", "type": "umlsterm", "text": [ "Knochenmarktransplantation" ], "offsets": [ [ 516, 542 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040732" }, { "db_name": "UMLS", "db_id": "C0040733" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t6", "type": "umlsterm", "text": [ "gezieltes" ], "offsets": [ [ 579, 588 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018017" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Zeit" ], "offsets": [ [ 664, 668 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Fallberichte" ], "offsets": [ [ 693, 705 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007320" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560173.ger.abstr-s1-r1-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s1-r2-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s1-r3-t3.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s1-r4-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s1-r5-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-r2-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-r3-t1.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-r4-t2.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-r5-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s2-r6-t1.1-t2.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r1-t2.2-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r3-t4.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r4-t2.2-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r5-t4.1-t2.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r6-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r7-t4.1-t2.2", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r8-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r10-t4.1-t2.2", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r11-t1.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r12-t2.1-t4.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r13-t1.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r14-t1.1-t2.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r15-t2.2-t4.1", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r16-t4.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r17-t5.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560173.ger.abstr-s3-r19-t2.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.70560173.ger.abstr-s3-t5", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560190.ger.abstr-passage-0", "type": "abstract", "text": [ "Der Stellenwert der arthroskopischen Synovektomie wird nach wie vor kontrovers diskutiert . Eine Auswertung der erreichbaren wissenschaftlichen Daten soll zur Standortbestimmung beitragen ." ], "offsets": [ [ 0, 189 ] ] } ]

[]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.70560200.ger.abstr-passage-0", "type": "abstract", "text": [ "Knie- und Funktionsscore von 28 Patienten mit Rheumatoider Arthritis wurden prospektiv praeoperativ , nach 3 Monaten und in Jahresintervallen postoperativ nach Implantation von 34 kreuzbanderhaltenden PFC-Knieprothesen mit dem Knee Society Clinical Rating System erfasst . Die Beobachtungszeit betrug durchschnittlich 3,4 Jahre ( 2-5 , 5 Jahre ) . Ueber 80% der Kniegelenke waren bei der letzten Beobachtung schmerzfrei . Bis auf einen konnten alle Patienten mehr als 500m gehen . Knie- und Funktionsscore stiegen signifikant von durchschnittlich 30,1 bzw. 35,0 auf 83,8 bzw. 74,6 an P 0,000001 ) . ( Postoperativ nahm der Kniescore rasch zu und blieb auf gleichem Niveau , waehrend der Funktionsscore einen langsameren kontinuierlichen Anstieg bis zur 5-Jahresbeobachtung aufwies . Als Komplikationen wurden eine Subluxation und eine tiefe Beinvenenthrombose beobachtet . Rheumatische Kniegelenksdestruktionen lassen sich mittelfristig mit ungekoppelten Oberflaechenersatzprothesen mit guten klinischen und funktionellen Ergebnissen versorgen , insbesondere was die Schmerzlinderung angeht . Die Verwendung von dualen Scores mit getrenntem gelenkbezogenem und funktionellem Resultat wird empfohlen ." ], "offsets": [ [ 0, 1200 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560200.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 32, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 59, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Rheumatoider Arthritis" ], "offsets": [ [ 46, 68 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Kniegelenke" ], "offsets": [ [ 362, 373 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Beobachtung" ], "offsets": [ [ 396, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 449, 458 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Komplikationen" ], "offsets": [ [ 787, 801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Beinvenenthrombose" ], "offsets": [ [ 841, 859 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023216" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Beinvenenthrombose" ], "offsets": [ [ 841, 859 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042449" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Beinvenenthrombose" ], "offsets": [ [ 841, 859 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040053" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Kniegelenksdestruktionen" ], "offsets": [ [ 886, 910 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Oberflaechenersatzprothesen" ], "offsets": [ [ 955, 982 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0175649" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Schmerzlinderung" ], "offsets": [ [ 1067, 1083 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Verwendung" ], "offsets": [ [ 1097, 1107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "gelenkbezogenem" ], "offsets": [ [ 1141, 1156 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560200.ger.abstr-s1-r1-t3.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s1-r2-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-r1-t1.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-r2-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-r3-t3.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-r4-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-r5-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-r6-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560200.ger.abstr-s7-r7-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560200.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560200.ger.abstr-s7-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560207.ger.abstr-passage-0", "type": "abstract", "text": [ "Ziel unserer 3jaehrigen , prospektiven Studie war die Wirksamkeit einer Radiosynoviorthese mit Rhenium-186 oder Erbium-169 , und zwar in der Therapie der rheumatischen Artikulosynovitis , anhand klinischer und radiologischer Parameter vergleichend zu beurteilen . Als Kontrolle diente die Injektionstherapie mit Triamcinolonhexacetonid . Als Studienkriterien wurden definiert : 1. Grunderkrankung chronische Polyarthritis ( ARA-Kriterien 1988 ) , 2. Patientenalter ueber 40 Jahre , 3. standardisierte , medikamentoese Therapie mit Methotrexat ( seit mind . 1/2 Jahr vor Studienbeginn und waehrend der gesamten Studie ) , Prednisolonaequivalent bis 7,5mg/d und Diclofenac bis 150mg/d, 4. keine Vorbehandlung des Gelenkes durch Injektionen oder Operationen . Die Behandlung erfolgte an Schulter- , Ellenbogen- , Hand- und Sprunggelenken mit Rhenium-186 ( Gruppe 1 , Kontrollgruppe=Gruppe 2 : je 50 Gelenke ) , an Fingergelenken ( MCP PIP ) , mit Erbium-169 ( Gruppe 3=131 Gelenke , Kontrollgruppe=Gruppe 4=86 Gelenke ) . Die Nuklide wurden jeweils in Kombination mit Triamcinolonhexacetonid injiziert . In den Kontrollgruppen erfolgte die alleinige Steroidinjektion in gleicher Dosierung . Waehrend des Studienzeitraums wurden Schmerz synovitische Schwellung , Bewegungsausmass und das radiologische Stadium , nach Larsen-Dale-Eek beurteilt . Nach 3 Jahren Follow up konnten entsprechend den genannten Kriterien in Gruppe 1=41 , Gruppe 2=21 , Gruppe 3=113 und Gruppe 4=53 Gelenke beurteilt werden ." ], "offsets": [ [ 0, 1496 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560207.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 141, 149 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "radiologischer" ], "offsets": [ [ 210, 224 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 408, 421 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Patientenalter" ], "offsets": [ [ 450, 464 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 518, 526 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Methotrexat" ], "offsets": [ [ 531, 542 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025677" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t5", "type": "umlsterm", "text": [ "chronische Polyarthritis" ], "offsets": [ [ 397, 421 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t6", "type": "umlsterm", "text": [ "medikamentoese Therapie" ], "offsets": [ [ 503, 526 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013216" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Diclofenac" ], "offsets": [ [ 660, 670 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012091" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Gelenkes" ], "offsets": [ [ 711, 719 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Injektionen" ], "offsets": [ [ 726, 737 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 761, 771 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Schulter-" ], "offsets": [ [ 784, 793 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037004" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Hand-" ], "offsets": [ [ 810, 815 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Sprunggelenken" ], "offsets": [ [ 820, 834 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003087" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 896, 903 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "Fingergelenken" ], "offsets": [ [ 911, 925 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016125" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t7", "type": "umlsterm", "text": [ "MCP" ], "offsets": [ [ 928, 931 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024994" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t8", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 970, 977 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t9", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 1007, 1014 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Steroidinjektion" ], "offsets": [ [ 1147, 1163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Steroidinjektion" ], "offsets": [ [ 1147, 1163 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Schmerz" ], "offsets": [ [ 1225, 1232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "radiologische" ], "offsets": [ [ 1284, 1297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 1470, 1477 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r1-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r2-t3.2-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r3-t5.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r4-t3.2-t5.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r5-t3.2-t1.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r6-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r7-t6.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r8-t1.1-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r9-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r10-t6.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r11-t1.1-t6.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r12-t3.1-t3.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r13-t6.1-t3.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r14-t5.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r15-t1.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r16-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r17-t6.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r18-t3.2-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s3-r19-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r1-t3.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r2-t3.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r3-t2.1-t6.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r4-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r5-t3.1-t9.1", "type": "interconnects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r6-t2.1-t5.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r7-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r8-t3.1-t8.1", "type": "interconnects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r9-t7.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r10-t2.1-t4.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r11-t2.1-t9.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r12-t3.1-t6.1", "type": "interconnects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r13-t2.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r14-t3.1-t5.1", "type": "interconnects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r15-t2.1-t8.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.70560207.ger.abstr-s5-r16-t3.1-t4.1", "type": "interconnects", "arg1_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560207.ger.abstr-s5-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560214.ger.abstr-passage-0", "type": "abstract", "text": [ "Infektionen mit Borrelia burgdorferi werden vereinzelt im Zusammenhang mit der Entwicklung einer diffusen Fasziitis ( eosinophile Fasziitis - Shulman's-Syndrom ) beschrieben . Es wird ueber einen solchen Fall eines 25-jaehrigen Patienten berichtet , bei dem aufgrund der Anamnese und typischer labormedizinischer Befunde eine Borrelieninfektion als moegliche Ursache einer nachfolgenden diffusen Fasziitis angenommen werden kann . Der histologische und molekularbiologische Nachweis von Borrelien bzw. Borrelien-DNA ( nested-PCR ) im Hautexzisat gelingt nicht ( mehr ) nach schon auswaerts begonnener Tetrazyklintherapie ." ], "offsets": [ [ 0, 622 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Infektionen" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021311" } ] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Borrelia" ], "offsets": [ [ 16, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006033" } ] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Fasziitis" ], "offsets": [ [ 106, 115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015645" } ] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Fasziitis" ], "offsets": [ [ 130, 139 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015645" } ] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Borrelia burgdorferi" ], "offsets": [ [ 16, 36 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006034" } ] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 228, 237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Fasziitis" ], "offsets": [ [ 396, 405 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015645" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r1-t2.1-t4.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r2-t2.1-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r3-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r4-t5.1-t4.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r5-t5.1-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r6-t2.1-t3.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r7-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r8-t5.1-t3.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r9-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r10-t1.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r11-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r12-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r13-t3.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r14-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r15-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r16-t4.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r17-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s1-r18-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560214.ger.abstr-s2-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.70560214.ger.abstr-s2-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560245.ger.abstr-passage-0", "type": "abstract", "text": [ "Erkrankungen des Bewegungsapparates verursachen in der Regel Schmerzen , eine Einschraenkung der physischen und psychischen Gesundheit , eine Beeintraechtigung bei der Ausuebung der Taetigkeiten des Alltags , des Berufs sowie des Rollenverstaendnisses in der Familie und der Gesellschaft . Dadurch kommt es oft zu einer erheblichen Verminderung der Lebensqualitaet . Mittlerweile ist es unumstritten , dass Patienten durchaus in der Lage sind , ihre Symptome und Funktionseinschraenkungen zuverlaessig zu beurteilen , insbesondere dann , wenn ihnen standardisierte und relevante Fragen gestellt werden . Krankheitsmodelle erleichtern dabei das Verstaendnis fuer die Messung der unterschiedlichen Outcome-Dimensionen . Heute ist eine standardisierte , gueltige und zuverlaessige Erfassung der Krankheitsauswirkungen mit Patientenfrageboegen die Grundlage weitreichender Forschungsvorhaben auf dem Gebiet der klinischen Epidemiologie , der oekonomischen Evaluation und der Gesundheitsforschung . Im Gegensatz zur breiten Anwendung der patienten-zentrierten Messung der Krankheitsauswirkungen in der Forschung , ist deren Einsatz in der klinischen Praxis jedoch noch nicht etabliert ." ], "offsets": [ [ 0, 1181 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 61, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Gesundheit" ], "offsets": [ [ 124, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018684" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Berufs" ], "offsets": [ [ 213, 219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028811" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Rollenverstaendnisses" ], "offsets": [ [ 230, 251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Familie" ], "offsets": [ [ 259, 266 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015576" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Gesellschaft" ], "offsets": [ [ 275, 287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037455" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t7", "type": "umlsterm", "text": [ "psychischen Gesundheit" ], "offsets": [ [ 112, 134 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025353" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Lebensqualitaet" ], "offsets": [ [ 349, 364 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034380" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Lebensqualitaet" ], "offsets": [ [ 349, 364 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 407, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Krankheitsauswirkungen" ], "offsets": [ [ 792, 814 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Patientenfrageboegen" ], "offsets": [ [ 819, 839 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Epidemiologie" ], "offsets": [ [ 918, 931 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014507" }, { "db_name": "UMLS", "db_id": "C0014508" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "patienten-zentrierten" ], "offsets": [ [ 1033, 1054 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Krankheitsauswirkungen" ], "offsets": [ [ 1067, 1089 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 1097, 1106 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Praxis" ], "offsets": [ [ 1145, 1151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033174" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r1-t5.1-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r2-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r3-t1.1-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r4-t7.1-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r5-t5.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r6-t4.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r7-t6.1-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r8-t2.1-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s1-r9-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s2-r1-t1.1-t2.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s5-r1-t1.1-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s5-r2-t1.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s5-r3-t3.2-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s5-r4-t2.1-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r1-t1.1-t4.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r2-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r3-t3.1-t4.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r4-t1.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r5-t2.1-t4.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r6-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r7-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r8-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r9-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560245.ger.abstr-s6-r10-t1.1-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.70560245.ger.abstr-s6-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560255.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Untersuchung der Effektivitaet und Kosten-Wirksamkeit von Interventionen , die Evaluation von epidemiologischen Studien der Krankheitsauswirkungen sowie Versorgungsstudien und klinisches Qualitaetsmanagement bedingen alle die standardisierte Erfassung von patienten-relevanten Parametern mit validierten , metrisch getesteten , zuverlaessigen und verlaufsempfindlichen Frageboegen . Dabei ist die sorgfaeltige Auswahl und Testung des Outcome-Instrumentariums in der Planungsphase aus wissenschaftlichen , ethischen und schlussendlich auch oekonomischen Gruenden ausschlaggebend . Die Auswahl von Instrumenten umfasst die Recherche mit Hilfe von medizinischen Datenbanken ( z . B. MEDLINE ) , die Pruefung der Face-Validitaet ( misst ein Instrument , was wir zu messen beabsichtigen ? ) und der Kompatibilitaet ( wird das Instrument international verwendet ? ) . Die Testung von Instrumenten umfasst die Pruefung der Zuverlaessigkeit ( reliability ) , der internen Konsistenz ( internal consistency ) und der Empfindlichkeit ( sensitivity ) . Wichtig ist die Pruefung der praktischen Eignung ( Interpretation der Skalen und Scores , Akzeptanz in der Studienpopulation ) . Vor Einsatz eines Instrumentes empfiehlt sich die Ruecksprache mit den Entwicklern ( Copyright Fragen , Scoring , aktuelle Version ) ." ], "offsets": [ [ 0, 1309 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560255.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Krankheitsauswirkungen" ], "offsets": [ [ 128, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "patienten-relevanten" ], "offsets": [ [ 260, 280 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Instrumenten" ], "offsets": [ [ 600, 612 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "MEDLINE" ], "offsets": [ [ 684, 691 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025141" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Instrument" ], "offsets": [ [ 741, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Instrument" ], "offsets": [ [ 825, 835 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Instrumenten" ], "offsets": [ [ 882, 894 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Eignung" ], "offsets": [ [ 1087, 1094 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003646" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Studienpopulation" ], "offsets": [ [ 1153, 1170 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032659" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Instrumentes" ], "offsets": [ [ 1193, 1205 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Copyright" ], "offsets": [ [ 1260, 1269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009993" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560255.ger.abstr-s1-r1-t1.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.70560255.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.70560255.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560255.ger.abstr-s8-r1-t2.1-t1.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.70560255.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.70560255.ger.abstr-s9-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560266.ger.abstr-passage-0", "type": "abstract", "text": [ "Die zuverlaessige ( reliable ) , gueltige ( valid und verlaufsempflindliche ( sensitive ) Beurteilung ) von Krankheitsauswirkungen setzt die Verwendung von standardisierten Messmethoden voraus . Fuer die Erfassung der allgemeinen Gesundheit stehen dabei ausgezeichnete , hinreichend erprobte und fuer den deutschen Sprachraum adaptierte Instrumente wie der SF-36 zur Verfuegung . Hingegen liegen krankheits- und problemspezifische Outcome-Instrumente oft nur in einer englischen Version vor und muessen fuer die deutsche Sprache adaptiert werden . Bei der Adaptation eines Instrumentes fuer den deutschen Sprachraum handelt es sich in der Regel nicht um eine simple Uebersetzung . Damit Resultate des gleichen Instrumentes in verschiedenen Sprachraeumen und Kulturen vergleichbar sind und ein Instrument z . B. in internationalen Multizenterstudien eingesetzt werden kann , ist einerseits eine inhaltliche und anderseits eine metrische Equivalenz der Instrumente erforderlich . Das typische Vorgehen bei der Adaptation eines Instrumentes umfasst die Uebersetzung , Rueckuebersetzung , Review und Testung . Die Testung umfasst einerseits die metrischen Eigenschaften ( Faktoren Zuverlaessigkeit , interne Konsistenz ) und , andererseits die Gueltigkeit des Instrumentes . Die Neuentwicklung eines Instrumentes sollte man nur dann in Erwaegung ziehen , wenn kein geeignetes Instrument zur Verfuegung steht . Die Neuentwicklung auch von kurzen Instrumenten ist zeit- und kostenintensiv . Idealerweise weisen neuentwickelte Instrumente Intervalleigenschaften auf ." ], "offsets": [ [ 0, 1560 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560266.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Beurteilung" ], "offsets": [ [ 90, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Krankheitsauswirkungen" ], "offsets": [ [ 108, 130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Verwendung" ], "offsets": [ [ 141, 151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Gesundheit" ], "offsets": [ [ 230, 240 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018684" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Instrumente" ], "offsets": [ [ 337, 348 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Sprache" ], "offsets": [ [ 521, 528 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023008" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Instrumentes" ], "offsets": [ [ 573, 585 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Uebersetzung" ], "offsets": [ [ 666, 678 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040712" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Instrumentes" ], "offsets": [ [ 710, 722 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Kulturen" ], "offsets": [ [ 758, 766 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010453" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Instrument" ], "offsets": [ [ 793, 803 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Instrumente" ], "offsets": [ [ 951, 962 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Instrumentes" ], "offsets": [ [ 1025, 1037 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Uebersetzung" ], "offsets": [ [ 1050, 1062 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040712" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Instrumentes" ], "offsets": [ [ 1256, 1268 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Instrumentes" ], "offsets": [ [ 1296, 1308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Instrument" ], "offsets": [ [ 1372, 1382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Instrumenten" ], "offsets": [ [ 1441, 1453 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "zeit-" ], "offsets": [ [ 1458, 1463 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Instrumente" ], "offsets": [ [ 1520, 1531 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560266.ger.abstr-s1-r1-t2.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560266.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.70560266.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s1-r2-t3.1-t1.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.70560266.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560266.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s1-r3-t1.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560266.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.70560266.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s2-r1-t2.1-t1.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560266.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.70560266.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560266.ger.abstr-s5-r1-t3.1-t1.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560266.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.70560266.ger.abstr-s11-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560287.ger.abstr-passage-0", "type": "abstract", "text": [ "Die durch einen Silastik-Platzhalter nach Swanson stabilisierte Resektionsarthroplastik gilt als Standardverfahren bei fortgeschrittener rheumatischer Destruktion des Fingergrundgelenkes . Drei Patientengruppen mit 57 ( Gr . I 91 ( ) , Gr . II ) und 102 ( Gr . III operierten Metacarpophalangealgelenken ) konnten postoperativ durchschnittlich nach 3,5 Jahren ( Gr . I ) , 4,3 Jahren ( Gr . II ) und 10,1 Jahren ( Gr . III ) nachuntersucht werden . In GruppeI wurden zusaetzlich Titangrommets verwendet . Nahezu alle Patienten gaben eine Schmerzlinderung an . Die mittlere Ulnardeviation wurde von praeoperativ 22 Grad ( Gr . I ) , 23 Grad ( Gr . II ) , 34 Grad ( Gr . III ) mittelfristig mit bzw. ohne Grommets auf 8 bzw. 7 Grad und langfristig auf 12 Grad postoperativ korrigiert . Die durchschnittliche aktive Beweglichkeit betrug praeoperativ 33 Grad ( Gr . I ) , 38 Grad ( Gr . II ) , 42 Grad ( Gr . III ) und war postoperativ mit 42 Grad ( Gr . I ) , 37 Grad ( Gr . II ) , 36 Grad ( Gr . III ) nicht wesentlich veraendert , wobei der Bewegungsbereich in einen funktionell guenstigeren Sektor verlagert wurde . Eine anhaltende Verbesserung der Handfunktion wurde mittelfristig von 82% und langfristig von 75% der Patienten angegeben . Die radiographisch erkennbare Rate der periimplantaren Osteolysen und der Implantatbrueche waren langfristig ( Gr . III ) mit 89,4% und 26,9% deutlich hoeher als mittelfristig ( Gr . II ) mit 63,5% und 16,5% . Mit zunehmender Implantationszeit kommt es zu einer Zunahme der radiologischen Veraenderungen . Durch die zusaetzliche Verwendung von Grommets ( Gr . I ) konnten mittelfristig Implantatbrueche verhindert werden und die Osteolyserate gesenkt werden . Die zusaetzliche Verwendung von Grommets ist daher empfehlenswert , obwohl ein wesentlicher Einfluss auf das klinische Ergebnis nicht zu erkennen ist ." ], "offsets": [ [ 0, 1851 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560287.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Standardverfahren" ], "offsets": [ [ 97, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038137" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Fingergrundgelenkes" ], "offsets": [ [ 167, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016129" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Fingergrundgelenkes" ], "offsets": [ [ 167, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Patientengruppen" ], "offsets": [ [ 194, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 517, 526 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "Schmerzlinderung" ], "offsets": [ [ 538, 554 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s22-t1", "type": "umlsterm", "text": [ "Handfunktion" ], "offsets": [ [ 1149, 1161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018563" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s22-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1218, 1227 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s23-t1", "type": "umlsterm", "text": [ "radiographisch" ], "offsets": [ [ 1244, 1258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s23-t2", "type": "umlsterm", "text": [ "Osteolysen" ], "offsets": [ [ 1295, 1305 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029435" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s26-t1", "type": "umlsterm", "text": [ "Implantationszeit" ], "offsets": [ [ 1466, 1483 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022023" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s26-t2", "type": "umlsterm", "text": [ "Implantationszeit" ], "offsets": [ [ 1466, 1483 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s26-t3", "type": "umlsterm", "text": [ "radiologischen" ], "offsets": [ [ 1514, 1528 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s27-t1", "type": "umlsterm", "text": [ "Verwendung" ], "offsets": [ [ 1569, 1579 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s28-t1", "type": "umlsterm", "text": [ "Osteolyserate" ], "offsets": [ [ 1669, 1682 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029435" } ] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s29-t1", "type": "umlsterm", "text": [ "Verwendung" ], "offsets": [ [ 1717, 1727 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560287.ger.abstr-s1-r1-t1.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560287.ger.abstr-s29-t1", "arg2_id": "ZfuerRheumatologie.70560287.ger.abstr-s26-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560287.ger.abstr-s1-r2-t3.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.70560287.ger.abstr-s26-t3", "arg2_id": "ZfuerRheumatologie.70560287.ger.abstr-s29-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560322.ger.abstr-passage-0", "type": "abstract", "text": [ "Lebensqualitaet und patienten-zentrierter Gesundheitsstatus haben in der Vergangenheit zunehmend an Bedeutung gewonnen . Zeitgleich wurde eine Vielzahl von Verfahren entwickelt , um Lebensqualitaet standardisiert zu erfassen . Hierbei lassen sich 3 verschiedene Methoden unterscheiden : ( 1 ) die Beurteilung durch einen Mediziner , ( 2 ) die Durchfuehrung standardisierter Aktivitaeten durch den Patienten und dessen Beurteilung ( z . B. Keitel Index ) und die Beantwortung standardisierter Frageboegen seitens der Patienten . Diese Arbeit beschreibt eine Auswahl von Instrumenten zur Erfassung von Funktion , Gesundheitsstatus und Lebensqualitaet bei Patienten mit rheumatischen Erkrankungen . Es werden Empfehlungen ausgegeben , die helfen sollen , Instrumente fuer unterschiedliche Zwecke in Praxis und Forschung auszuwaehlen . Dabei beschraenken wir uns auf Instrumente , deren Validitaet ( Gueltigkeit Reliabilitaet ( ) , Zuverlaessigkeit ) , und Sensitivitaet ( Verlaufsempfindlichkeit ) nachgewiesen und in der wissenschaftlichen Literatur dokumentiert wurden ." ], "offsets": [ [ 0, 1069 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560322.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Lebensqualitaet" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034380" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Lebensqualitaet" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "patienten-zentrierter" ], "offsets": [ [ 20, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Gesundheitsstatus" ], "offsets": [ [ 42, 59 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018759" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Lebensqualitaet" ], "offsets": [ [ 182, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034380" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Lebensqualitaet" ], "offsets": [ [ 182, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Methoden" ], "offsets": [ [ 262, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Beurteilung" ], "offsets": [ [ 297, 308 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 397, 406 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Beurteilung" ], "offsets": [ [ 418, 429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 516, 525 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Arbeit" ], "offsets": [ [ 534, 540 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Instrumenten" ], "offsets": [ [ 569, 581 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Gesundheitsstatus" ], "offsets": [ [ 611, 628 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018759" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Lebensqualitaet" ], "offsets": [ [ 633, 648 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034380" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Lebensqualitaet" ], "offsets": [ [ 633, 648 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 653, 662 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Instrumente" ], "offsets": [ [ 752, 763 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Praxis" ], "offsets": [ [ 796, 802 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033174" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 807, 816 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Instrumente" ], "offsets": [ [ 863, 874 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Literatur" ], "offsets": [ [ 1038, 1047 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560322.ger.abstr-s1-r1-t4.1-t2.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s1-r2-t1.1-t2.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s2-r1-t1.1-t2.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-r1-t1.1-t1.2", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-r2-t4.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-r3-t1.2-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-r4-t3.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-r5-t3.1-t1.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s3-r6-t1.1-t4.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-r1-t6.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-r2-t4.1-t5.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-r3-t2.1-t5.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-r4-t2.1-t1.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s5-r5-t4.1-t1.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s6-r1-t3.1-t1.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560322.ger.abstr-s6-r2-t3.1-t1.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.70560322.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.70560322.ger.abstr-s7-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560334.ger.abstr-passage-0", "type": "abstract", "text": [ "Es wurde geprueft , inwiefern sich Fibromyalgiepatienten nicht nur in der somatosensorischen , sondern auch in der Wahrnehmung und Verarbeitung externer Reize von Kontrollprobanden ohne generalisierte Schmerzen unterscheiden . Dazu wurden 30 Fibromyalgiepatienten mit 36 ueberwiegend schmerzfreien Kontrollprobanden hinsichtlich auditiver Wahrnehmungsleistungen verglichen . Die Gruppen waren nach Alter und dem Ausmass hoerorganisch nachweisbarer Schaedigungen parallelisiert . Audiometrisch wurden Aversions- und Hoerschwellen bestimmt . Zusaetzlich machten die Teilnehmer Angaben zur Laermerfahrung im Alltag , zur Vulnerabilitaet fuer Laermstress und zu fibromyalgieassoziierten Beschwerden . Die Ergebnisse zeigen bei Fibromyalgiepatienten die erwartete frequenzunabhaengig reduzierte auditive Aversionsschwelle sowie im oberen Frequenzbereich einen asymptomatischen Hoerverlust . Als gruppenuebergreifend signifikantes Korrelat der Hoerschwellenerhoehung erwies sich die selbstberichtete Laermerfahrung am Arbeitsplatz , die bei Fibromyalgiepatienten erhoeht war . Die Bewertung von Alltagslaerm kovariierte ebenso wie die bewertungsabhaengige auditive Aversionsschwelle mit der klinischen Schmerzausdehnung . Aversions- und Hoerschwellendifferenzen werden als zwei Formen vorbewusster oder bewusster Methoden der Reizabschirmung bei Fibromyalgiepatienten interpretiert . Die Ergebnisse sprechen fuer eine nicht nur schmerzspezifische Stoerung der Reizverarbeitung . Erhoehte multilokulaere Druckschmerzhaftigkeit bei Fibromyalgie kann als eine von mehreren Manifestationen einer durch allgemeine Schwellenveraenderungen und reduzierte Differenzierungsfaehigkeit gekennzeichneten Reaktion auf externe Stimulation verstanden werden ." ], "offsets": [ [ 0, 1738 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560334.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Wahrnehmung" ], "offsets": [ [ 115, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030971" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 201, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Aversions-" ], "offsets": [ [ 500, 510 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022023" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Hoerschwellen" ], "offsets": [ [ 515, 528 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004312" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Laermerfahrung" ], "offsets": [ [ 587, 601 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028263" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Laermstress" ], "offsets": [ [ 639, 650 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028263" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Laermstress" ], "offsets": [ [ 639, 650 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038435" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Aversionsschwelle" ], "offsets": [ [ 799, 816 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022023" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Hoerverlust" ], "offsets": [ [ 872, 883 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011053" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Hoerschwellenerhoehung" ], "offsets": [ [ 938, 960 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004312" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Laermerfahrung" ], "offsets": [ [ 994, 1008 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028263" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Arbeitsplatz" ], "offsets": [ [ 1012, 1024 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162579" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Alltagslaerm" ], "offsets": [ [ 1089, 1101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028263" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Aversionsschwelle" ], "offsets": [ [ 1159, 1176 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022023" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Schmerzausdehnung" ], "offsets": [ [ 1196, 1213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Aversions-" ], "offsets": [ [ 1216, 1226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022023" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Hoerschwellendifferenzen" ], "offsets": [ [ 1231, 1255 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004312" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s9-t3", "type": "umlsterm", "text": [ "Methoden" ], "offsets": [ [ 1307, 1315 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "schmerzspezifische" ], "offsets": [ [ 1422, 1440 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Druckschmerzhaftigkeit" ], "offsets": [ [ 1497, 1519 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t2", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 1524, 1536 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560334.ger.abstr-s1-r1-t2.1-t1.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t2", "arg2_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s5-r1-t2.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t2", "arg2_id": "ZfuerRheumatologie.70560334.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s5-r2-t1.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.70560334.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s5-r3-t3.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560334.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s5-r4-t3.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.70560334.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s6-r1-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.70560334.ger.abstr-s7-r1-t1.1-t3.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.70560334.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.70560334.ger.abstr-s9-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.70560342.ger.abstr-passage-0", "type": "abstract", "text": [ "Arthrose ist die haeufigste Form der Gelenkerkrankungen . Neben verschiedenen bekannten Faktoren wie z.B. Genetik , Alter und Hormonstatus werden chronisch-repetitive Mikro- und Makrotraumatisierungen bei der Fingerpolyarthrose ( FIPO ) als Ursache diskutiert ." ], "offsets": [ [ 0, 261 ] ] } ]

[ { "id": "ZfuerRheumatologie.70560342.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arthrose" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022408" } ] }, { "id": "ZfuerRheumatologie.70560342.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Gelenkerkrankungen" ], "offsets": [ [ 37, 55 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.70560342.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Genetik" ], "offsets": [ [ 106, 113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017398" }, { "db_name": "UMLS", "db_id": "C0017399" } ] }, { "id": "ZfuerRheumatologie.70560342.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Hormonstatus" ], "offsets": [ [ 126, 138 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019932" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.70560342.ger.abstr-s1-r1-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.70560342.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.70560342.ger.abstr-s2-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570005.ger.abstr-passage-0", "type": "abstract", "text": [ "Bei der Beurteilung der Kniegelenksfunktion bei Varusgonarthrose kommt der Untersuchung von Propriozeptionsveraenderungen eine wachsende Bedeutung zu . In Anbetracht der in der Literatur gegenueber den Gelenkstellungssinn-Messungen geaeusserten Methodenkritik entwickelten wir ein eigenes Verfahren zur Bestimmung der Kniegelenkskinaesthesie als wichtigem Parameter der Propriozeption . Dabei wird bei 5 unterschiedlichen Winkelgeschwindigkeiten der passiven Kniegelenksbewegung die Faehigkeit sowohl zur Bewegungs- als auch zur Stopdetektion bestimmt . Wir untersuchten mit dieser Methode 25 Patienten mit klinisch und radiologisch gesicherter Varusgonarthrose ( VGA ) sowie 20 altersgleiche Normalpersonen . Neben einer Zunahme der propriozeptiven Faehigkeiten mit steigender Winkelgeschwindigkeit erbrachte die Detektionsfehler-Analyse signifikant hoehere Fehlerraten bei der Bewegungs- und Stopdetektion in der VGA-Gruppe gegenueber der Kontroll-Gruppe und somit ein deutliches propriozeptives Defizit bei Gonarthrose . Dagegen zeigten sich bei korrekter Detektion keine signifikanten Unterschiede in den Schwellenwerten der Bewegungs- und Stopdetektion zwischen der VGA- und der Kontroll-Gruppe . Anhand der vorliegenden Kinaesthesiemessungen konnten wir ein deutliches propriozeptives Defizit bei Varusgonarthrose zeigen . Das Fehlen von Unterschieden in den Detektionsschwellenwerten zwischen Kontroll- und VGA-Gruppe einerseits und die deutlich erhoehten Detektionsfehlerraten der VGA-Patienten andererseits betrachten wir als Hinweis darauf , dass das propriozeptive Defizit bei Varusgonarthrose massgeblich in einer Stoerung der Verarbeitung propriozeptiver Afferenzen seinen Ursprung hat ." ], "offsets": [ [ 0, 1700 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570005.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Beurteilung" ], "offsets": [ [ 8, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Kniegelenksfunktion" ], "offsets": [ [ 24, 43 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "wachsende" ], "offsets": [ [ 127, 136 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043076" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Literatur" ], "offsets": [ [ 177, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023866" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Methodenkritik" ], "offsets": [ [ 245, 259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Kniegelenkskinaesthesie" ], "offsets": [ [ 318, 341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Kniegelenkskinaesthesie" ], "offsets": [ [ 318, 341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022701" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Propriozeption" ], "offsets": [ [ 370, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033499" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Kniegelenksbewegung" ], "offsets": [ [ 459, 478 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Faehigkeit" ], "offsets": [ [ 483, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085732" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Methode" ], "offsets": [ [ 582, 589 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 593, 602 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "radiologisch" ], "offsets": [ [ 620, 632 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Normalpersonen" ], "offsets": [ [ 693, 707 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027361" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Faehigkeiten" ], "offsets": [ [ 750, 762 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085732" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Gonarthrose" ], "offsets": [ [ 1010, 1021 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0409959" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Schwellenwerten" ], "offsets": [ [ 1109, 1124 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0752076" } ] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Kinaesthesiemessungen" ], "offsets": [ [ 1226, 1247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022701" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570005.ger.abstr-s1-r1-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s1-r2-t2.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r1-t5.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r2-t4.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r3-t2.2-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r4-t2.1-t5.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r5-t2.1-t4.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r6-t2.2-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r7-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r8-t2.2-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s2-r9-t5.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-r1-t1.2-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-r2-t4.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-r3-t1.2-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-r4-t1.2-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-r5-t4.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-r6-t4.1-t1.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570005.ger.abstr-s4-r7-t4.1-t1.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570005.ger.abstr-s4-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570011.ger.abstr-passage-0", "type": "abstract", "text": [ "Leukotriene stellen neben den Prostaglandinen wichtige Vermittler der Entzuendungsreaktion dar . Waehrend durch NSAR eine wirksame Prostaglandinsynthesehemmung moeglich ist , sind therapeutische Einfluesse auf die 5-Lipoxygenase , das Schluesselenzym der Leukotriensynthese , begrenzt . Harzextrakte von Boswellia serrata ( H15, indischer Weihrauch ) , ein Wirkstoff der ayurvedischen Medizin , hemmen in vitro die Leukotriensynthese . Einzelfallberichte lassen auf eine klinische Relevanz bei der cP hoffen . Methodik : Ambulante Patienten mit einer langjaehrigen , nach ACR-Kriterien sicheren chronischen Polyarthritis wurden bei konstanter Steroiddosis und Basistherapie mit 9 Tabletten/Tag H15 oder Placebo ueber 12 Wochen therapiert . NSAR konnten bedarfsweise angepasst werden . Vor Therapiebeginn , nach 6 und 12 Wochen wurden Daten zur Beurteilung der Effektivitaet dokumentiert : Ritchie Index Schmerz , Ritchie Index Schwellung , BSG , CRP , subjektive Einschaetzung des Patienten auf visueller Analogskala und NSAR-Verbrauch ( Skala zur relativen Aenderung , -5 bis +5 ) . Mittelwerte und Mediane wurden berechnet und die Gruppen verglichen . Ergebnis : Insgesamt 78 Patienten wurden in 4 Zentren therapiert . Die Ergebnisse wurden bislang nur als Abstract publiziert . Uns standen nur Daten der 37 in Ratingen rekrutierten Patienten zur Verfuegung : Es wurden 18 Patienten mit Verum und 19 mit Placebo therapiert und von einem Untersucher ( G.H. ) befundet . Bei keinem der untersuchten subjektiven , blutchemischen und Laborparameter kam es zu signifikanten oder klinisch relevanten Aenderungen zum Ausgangswert oder zu Unterschieden zwischen Verum- und Placeboguppe . Die Dosisreduktion der NSAR lag im Median bei beiden Gruppen bei 0 , im Mittel bei -5 , 8% ( H15) und -3 , 1% ( Placebo ) . Nur jeweils ein Patient der Verum- und Placebogruppe zeigte eine deutliche Besserung saemtlicher Parameter . Jeweils vier Patienten beider Gruppen zeigten einen Anstieg der Krankheitsaktivitaet . Die Aenderungen bei den uebrigen Patienten waren gering . Schlussfolgerung : Die Therapie mit H15 hatte bei unseren Patienten keinen messbaren Effekt . Kontrollierte Studien bei einer groesseren Patientenzahl waeren erforderlich um dieses Ergebnis zu bestaetigen oder zu widerlegen ." ], "offsets": [ [ 0, 2285 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570011.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Leukotriene" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023545" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Prostaglandinen" ], "offsets": [ [ 30, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033554" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Prostaglandinsynthesehemmung" ], "offsets": [ [ 131, 159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033554" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "5-Lipoxygenase" ], "offsets": [ [ 214, 228 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003693" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Schluesselenzym" ], "offsets": [ [ 235, 250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014442" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Medizin" ], "offsets": [ [ 385, 392 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025118" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "in vitro" ], "offsets": [ [ 402, 410 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021135" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Methodik" ], "offsets": [ [ 510, 518 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 531, 540 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 607, 620 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Steroiddosis" ], "offsets": [ [ 643, 655 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Basistherapie" ], "offsets": [ [ 660, 673 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "Placebo" ], "offsets": [ [ 703, 710 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t7", "type": "umlsterm", "text": [ "Ambulante Patienten" ], "offsets": [ [ 521, 540 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029921" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "type": "umlsterm", "text": [ "chronischen Polyarthritis" ], "offsets": [ [ 595, 620 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Therapiebeginn" ], "offsets": [ [ 789, 803 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Beurteilung" ], "offsets": [ [ 844, 855 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Schmerz" ], "offsets": [ [ 903, 910 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 981, 990 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1178, 1187 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1335, 1344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1375, 1384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "type": "umlsterm", "text": [ "Placebo" ], "offsets": [ [ 1406, 1413 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s12-t1", "type": "umlsterm", "text": [ "blutchemischen" ], "offsets": [ [ 1513, 1527 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s13-t1", "type": "umlsterm", "text": [ "Placebo" ], "offsets": [ [ 1794, 1801 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s14-t1", "type": "umlsterm", "text": [ "Patient" ], "offsets": [ [ 1822, 1829 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s14-t2", "type": "umlsterm", "text": [ "Placebogruppe" ], "offsets": [ [ 1845, 1858 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s15-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1928, 1937 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s16-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 2035, 2044 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 2083, 2091 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 2118, 2127 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "type": "umlsterm", "text": [ "Patientenzahl" ], "offsets": [ [ 2197, 2210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570011.ger.abstr-s1-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s1-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-r3-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-r4-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-r5-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s2-r6-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s3-r1-t2.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r1-t3.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r2-t5.2-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r3-t8.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r4-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r5-t5.1-t7.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r6-t5.2-t8.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r7-t8.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r8-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r9-t7.1-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r10-t1.1-t8.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r11-t8.1-t7.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r12-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r13-t7.1-t5.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r14-t2.1-t5.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r16-t3.1-t8.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r17-t3.1-t7.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r18-t2.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r19-t7.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r20-t8.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r21-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r22-t5.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r23-t2.1-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s5-r24-t5.1-t8.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s5-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-r1-t3.1-t1.2", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-r2-t4.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-r3-t1.1-t1.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-r4-t1.1-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s7-r5-t1.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s11-r1-t2.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s11-r2-t1.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s12-r1-t1.2-t1.1", "type": "derivative_of", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s12-r2-t1.1-t1.2", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s14-r1-t1.1-t2.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s17-r1-t1.1-t1.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570011.ger.abstr-s17-r2-t1.2-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570011.ger.abstr-s17-t1", "arg2_id": "ZfuerRheumatologie.80570011.ger.abstr-s18-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570025.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Kombinationstherapie der rheumatoiden Arthritis will eine bessere Krankheitskontrolle erzielen als die konventionelle Monotherapie . Auf dem Boden vieler klinischer Studien , die mehr oder weniger positive Ergebnisse erbrachten , sind verschiedene Kombinationen untersucht worden : ..." ], "offsets": [ [ 0, 289 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Kombinationstherapie" ], "offsets": [ [ 4, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022023" } ] }, { "id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Kombinationstherapie" ], "offsets": [ [ 4, 24 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 42, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 29, 51 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570025.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Boden" ], "offsets": [ [ 145, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037592" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570025.ger.abstr-s1-r1-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570025.ger.abstr-s1-r3-t1.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570025.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570025.ger.abstr-s1-r4-t1.1-t2.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570025.ger.abstr-s2-t1", "arg2_id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570025.ger.abstr-s1-r5-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.80570025.ger.abstr-s1-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570050.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Ochronose ist eine seltene , autosomal rezessiv vererbte Stoerung des Tyrosinabbaus . Ihre Symptome manifestieren sich ueberwiegend am Bewegungsapparat . Entzuendungsschuebe insbesondere an den grossen Gelenken koennen eine Chronische Polyarthritis ( CP ) vortaeuschen . Charakteristisch sind braeunliche Verfaerbungen der Skleren und Knorpel , die Diagnose kann dann durch typische Roentgenveraenderungen der Wirbelsaeule und den Nachweis von Homogentisinsaeure im Urin gesichert werden . Wir beschreiben den Fall einer 53-jaehrigen Patientin mit Ochronose und einer zusaetzlichen CP ." ], "offsets": [ [ 0, 590 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570050.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Ochronose" ], "offsets": [ [ 4, 13 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028817" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Tyrosinabbaus" ], "offsets": [ [ 74, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041485" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Bewegungsapparat" ], "offsets": [ [ 139, 155 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026860" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Gelenken" ], "offsets": [ [ 206, 214 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 239, 252 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Chronische Polyarthritis" ], "offsets": [ [ 228, 252 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Knorpel" ], "offsets": [ [ 339, 346 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007301" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Diagnose" ], "offsets": [ [ 353, 361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Wirbelsaeule" ], "offsets": [ [ 414, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037949" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Homogentisinsaeure" ], "offsets": [ [ 448, 466 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019881" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "Urin" ], "offsets": [ [ 470, 474 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Ochronose" ], "offsets": [ [ 552, 561 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028817" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570050.ger.abstr-s1-r1-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s1-r2-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s3-r1-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r1-t1.1-t2.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r2-t2.1-t5.1", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r3-t1.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r4-t2.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r5-t5.1-t4.1", "type": "consists_of", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r6-t5.1-t1.1", "type": "derivative_of", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r7-t2.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r8-t4.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r9-t5.1-t2.1", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r10-t1.1-t5.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570050.ger.abstr-s4-r11-t4.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570050.ger.abstr-s4-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570082.ger.abstr-passage-0", "type": "abstract", "text": [ "Borrelia burgdorferi - spezifische DNA laesst sich mittels Polymerase-Kettenreaktion ( PCR ) in verschiedenen Untersuchungsmaterialien von Patienten mit einer Lyme-Borreliose ( LB ) nachweisen . Ziel der vorliegenden Untersuchung ist es , den Wert der PCR-Untersuchungen von Urin im Hinblick auf die rheumatologische Diagnostik der Lyme-Borreliose zu ueberpruefen . Von 77 Patienten ( LB n=34, undifferenzierte Arthritis ( UA ) n=25, Arthralgien/Myalgien ( AM n=18) und 15 Kontrollpersonen ) wurden Urinproben untersucht . Als Zielsequenzen dienten Flagellin-Gen ( 60 Proben ) oder OspA-Plasmid ( 32 Proben ) . Es fand sich eine Sensitivitaet der Flagellin-nested-PCR von 27% , mittels OspA-nested-PCR wurde dagegen nur ein positiver Befund erhoben . Trotz formal niedriger Sensitivitaet konnte bei 2 Patienten mit einer UA erst durch die PCR die Diagnose LB gesichert werden . In Einzelfaellen bietet die PCR somit diagnostisch wertvolle Hinweise bei klinischem Verdacht auf eine LB ." ], "offsets": [ [ 0, 985 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Borrelia" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006033" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "DNA" ], "offsets": [ [ 35, 38 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012854" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Polymerase-Kettenreaktion" ], "offsets": [ [ 59, 84 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032520" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "PCR" ], "offsets": [ [ 87, 90 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032520" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 139, 148 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Lyme-Borreliose" ], "offsets": [ [ 159, 174 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024198" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t7", "type": "umlsterm", "text": [ "Borrelia burgdorferi" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006034" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Urin" ], "offsets": [ [ 275, 279 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Diagnostik" ], "offsets": [ [ 317, 327 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Lyme-Borreliose" ], "offsets": [ [ 332, 347 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024198" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 373, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 411, 420 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Urinproben" ], "offsets": [ [ 499, 509 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 801, 810 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "PCR" ], "offsets": [ [ 839, 842 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032520" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Diagnose" ], "offsets": [ [ 847, 855 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "PCR" ], "offsets": [ [ 906, 909 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032520" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r1-t4.1-t2.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r2-t5.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r3-t6.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r4-t7.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r5-t7.1-t6.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r6-t6.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r7-t4.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r8-t1.1-t6.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r9-t6.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r10-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r11-t6.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r12-t6.1-t5.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r13-t5.1-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r14-t2.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r15-t3.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r16-t6.1-t7.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s1-r17-t3.1-t2.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s2-r1-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s2-r2-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s2-r3-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s2-r4-t1.1-t3.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s2-r5-t2.1-t1.1", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s3-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s3-r2-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s3-r3-t3.1-t2.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570082.ger.abstr-s6-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570082.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.80570082.ger.abstr-s6-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570101.ger.abstr-passage-0", "type": "abstract", "text": [ "Fuer die Behandlung von Patienten mit therapierefraktaerer rheumatoider Arthritis ist die orale Gabe von Cyclophosphamid ( CYC ) eine in ihrer Wirksamkeit gesicherte Alternative . Allerdings findet diese Therapieform in der klinischen Praxis wegen z.T. betraechtlicher Nebenwirkungen wie Myelosuppression und Kanzerogenitaet nur noch selten Anwendung . Dabei ist jedoch durch die bisher veroeffentlichten Studien die Frage nach einem vernuenftigen Dosiskompromiss zwischen Toxizitaet und Wirksamkeit nicht befriedigend beantwortet ." ], "offsets": [ [ 0, 532 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 9, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 24, 33 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "therapierefraktaerer" ], "offsets": [ [ 38, 58 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 72, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Cyclophosphamid" ], "offsets": [ [ 105, 120 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010583" } ] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "rheumatoider Arthritis" ], "offsets": [ [ 59, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Therapieform" ], "offsets": [ [ 204, 216 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Praxis" ], "offsets": [ [ 235, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033174" } ] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Toxizitaet" ], "offsets": [ [ 473, 483 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040539" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r1-t3.2-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r2-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r3-t5.1-t6.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r4-t3.2-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r5-t5.1-t3.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r6-t1.1-t5.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r7-t3.1-t5.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r8-t3.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r10-t2.1-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r11-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r12-t6.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r13-t5.1-t3.2", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r14-t6.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r15-t5.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r16-t1.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r17-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r18-t6.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s1-r19-t1.1-t3.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s2-r1-t1.1-t1.2", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570101.ger.abstr-s2-r2-t1.1-t1.2", "type": "isa", "arg1_id": "ZfuerRheumatologie.80570101.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570101.ger.abstr-s2-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570108.ger.abstr-passage-0", "type": "abstract", "text": [ "Fragestellung : Mit der vorliegenden Studie sollte die Wirksamkeit , Patientenakzeptanz und das Nebenwirkungsprofil von Oxaprozin im Vergleich zu Diclofenac retard bei Patienten mit aktivierter primaerer Arthrose geprueft werden ." ], "offsets": [ [ 0, 230 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Patientenakzeptanz" ], "offsets": [ [ 69, 87 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Diclofenac" ], "offsets": [ [ 146, 156 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012091" } ] }, { "id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 168, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Arthrose" ], "offsets": [ [ 204, 212 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022408" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570108.ger.abstr-s1-r1-t2.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570108.ger.abstr-s1-r2-t4.1-t3.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570108.ger.abstr-s1-r3-t4.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570108.ger.abstr-s1-r4-t2.1-t4.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.80570108.ger.abstr-s1-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570114.ger.abstr-passage-0", "type": "abstract", "text": [ "Wir berichten ueber eine 26-jaehrige Patientin mit einer seit dem 10. Lebensjahr bekannten Dermatitis herpetiformis Duhring , die ueber arthritische Kniegelenksbeschwerden , rezidivierende Diarrhoen und eine Sicca-Symptomatik klagt . Klinisches Bild , serologische Befunde und die Histologien von Duodenalschleimhaut und Lippenbiopsie ergeben als Diagnose eine Zoeliakie und ein Sjoegren-Syndrom . Nach unseren Erkenntnissen ist ein gemeinsames Auftreten dieser verschiedenen Krankheitsbilder bisher nicht beschrieben worden . Durch die Einleitung einer glutenfreien Diaet kommt es zu einer schnellen Besserung der klinischen Symptomatik , so dass die Zoeliakie als die eigentliche Stoerung im Gefuege der einzelnen immunologischen Krankheitsbilder betrachtet werden kann ." ], "offsets": [ [ 0, 773 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Dermatitis" ], "offsets": [ [ 91, 101 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011603" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Kniegelenksbeschwerden" ], "offsets": [ [ 149, 171 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Diarrhoen" ], "offsets": [ [ 189, 198 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011991" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Dermatitis herpetiformis Duhring" ], "offsets": [ [ 91, 123 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011608" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Histologien" ], "offsets": [ [ 281, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019638" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Duodenalschleimhaut" ], "offsets": [ [ 297, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026724" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Lippenbiopsie" ], "offsets": [ [ 321, 334 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023759" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Lippenbiopsie" ], "offsets": [ [ 321, 334 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005558" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Diagnose" ], "offsets": [ [ 347, 355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Zoeliakie" ], "offsets": [ [ 361, 370 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007570" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t7", "type": "umlsterm", "text": [ "Sjoegren-Syndrom" ], "offsets": [ [ 379, 395 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037230" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Diaet" ], "offsets": [ [ 567, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012155" } ] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Zoeliakie" ], "offsets": [ [ 652, 661 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007570" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-r1-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-r2-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-r3-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-r4-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-r5-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s1-r6-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r1-t2.1-t7.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r2-t3.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r3-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r4-t5.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r5-t3.1-t7.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r6-t5.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r7-t2.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r8-t7.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r9-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r10-t5.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r11-t3.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r12-t4.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r13-t4.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r14-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r15-t7.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r16-t7.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r17-t4.1-t1.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s2-r18-t2.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570114.ger.abstr-s4-r1-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570114.ger.abstr-s4-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570118.ger.abstr-passage-0", "type": "abstract", "text": [ "Bei einer 57-jaehrigen Patientin mit einer progressiven systemischen Sklerodermie wurde eine prolongierte Therapie mit Iloprost ueber 21 Tage durchgefuehrt . Die Dosierung betrug ueber eine Einschleichphase von 6 Tagen 2 ng/kgKGxmin . Die Therapie fuehrte zu einer Verbesserung der Entzuendungsparameter , der Lungenfunktion , insbesodere der Diffusionskapazitaet und der ausgepraegten akralen Durchblutungsstoerung . Die Kasuistik unterstreicht die Notwendigkeit einer kontrollierten Studie , die den Effekt einer Verlaengerung der Therapie mit Iloprost im Vergleich zu bisher durchgefuehrten Studien , die in der Regel ueber drei bis fuenf Tage erfolgten , auf Symptome der Sklerodermie untersucht ." ], "offsets": [ [ 0, 701 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Sklerodermie" ], "offsets": [ [ 69, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011644" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 106, 114 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Iloprost" ], "offsets": [ [ 119, 127 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079594" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "systemischen Sklerodermie" ], "offsets": [ [ 56, 81 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036421" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 239, 247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Lungenfunktion" ], "offsets": [ [ 310, 324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024109" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Diffusionskapazitaet" ], "offsets": [ [ 343, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022023" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Durchblutungsstoerung" ], "offsets": [ [ 394, 415 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022116" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 533, 541 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Iloprost" ], "offsets": [ [ 546, 554 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079594" } ] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Sklerodermie" ], "offsets": [ [ 676, 688 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011644" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-r1-t1.1-t2.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-r2-t2.2-t4.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-r3-t2.2-t1.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-r4-t2.2-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-r5-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-r6-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s1-r7-t2.2-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s3-r1-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s3-r2-t1.2-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s3-r3-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s3-r4-t3.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s4-r1-t1.2-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s4-r2-t1.2-t3.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s4-r3-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570118.ger.abstr-s4-r5-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.80570118.ger.abstr-s4-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570139.ger.abstr-passage-0", "type": "abstract", "text": [ "Mit einem zunehmenden Kentnisstand ueber pathogenetische Mechanismen , die bei der rheumatoiden Arthritis zu einer Gelenkdestruktion fuehren , haben sich neue Therapieprinzipien entwickeln lassen , die durch eine Blockade von proinflammatorischen Zytokinen oder der Anwendung von antiinflammatorischen Zytokinen den Krankheitsverlauf zum Teil ausserordentlich guenstig beeinflussen . Mit den zusaetzlichen Moeglichkeiten , Gene fuer antiinflammatorische Therapieprinzipien wie den Interleukin 1 Rezeptorantagonisten in Zellen einzubringen , sind auch erste Versuche , basierend auf vorangegangenen Experimenten im Versuchstier , bei Patienten mit einer RA vorgenommen worden , mit dem Ziel die Krankheitsaktivitaet durch die intraartikulaere Injektion von transduzierten autologen Zellen zu behandeln . Die ersten Versuche sind ermutigend , doch ist es zu frueh , dieses Therapieprinzip als eine Behandlungsmethode fuer die rheumatoide Arthritis anzubieten . Weitere Untersuchungen , nicht zuletzt hinsichtlich der Bereitstellung besserer Vektoren sind notwendig , um eine Gentherapie der rheumatoiden Arthritis zu realisieren ." ], "offsets": [ [ 0, 1128 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 96, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Gelenkdestruktion" ], "offsets": [ [ 115, 132 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Therapieprinzipien" ], "offsets": [ [ 159, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 83, 105 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Gene" ], "offsets": [ [ 423, 427 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Therapieprinzipien" ], "offsets": [ [ 454, 472 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Interleukin" ], "offsets": [ [ 481, 492 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021764" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 519, 525 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Versuchstier" ], "offsets": [ [ 614, 626 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003064" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 633, 642 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t7", "type": "umlsterm", "text": [ "Injektion" ], "offsets": [ [ 742, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t8", "type": "umlsterm", "text": [ "Zellen" ], "offsets": [ [ 781, 787 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t9", "type": "umlsterm", "text": [ "intraartikulaere Injektion" ], "offsets": [ [ 725, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021488" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Therapieprinzip" ], "offsets": [ [ 871, 886 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 936, 945 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "rheumatoide Arthritis" ], "offsets": [ [ 924, 945 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Gentherapie" ], "offsets": [ [ 1073, 1084 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017296" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Gentherapie" ], "offsets": [ [ 1073, 1084 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Gentherapie" ], "offsets": [ [ 1073, 1084 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 1102, 1111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 1089, 1111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-r1-t2.1-t3.2", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-r2-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-r4-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-r5-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s1-r7-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r1-t8.1-t9.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t8", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r2-t9.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t9", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r3-t1.1-t5.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r4-t4.1-t9.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r5-t1.1-t8.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r6-t4.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r7-t6.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r8-t6.1-t9.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r9-t8.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t8", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r10-t4.1-t5.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r11-t2.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r12-t1.1-t4.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r13-t4.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t4", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r14-t9.1-t7.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t9", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r15-t2.2-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r16-t2.2-t8.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r17-t8.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t8", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r18-t2.2-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r19-t8.1-t5.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t8", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r20-t2.1-t7.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r21-t1.1-t2.2", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s2-r22-t6.1-t7.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s3-r1-t1.2-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s3-r2-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s3-r3-t1.1-t1.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s3-r4-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r1-t1.1-t3.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r2-t3.2-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r3-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r4-t5.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r5-t2.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r6-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r8-t2.1-t3.2", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r9-t1.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570139.ger.abstr-s4-r10-t1.1-t3.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570139.ger.abstr-s4-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570147.ger.abstr-passage-0", "type": "abstract", "text": [ "Zielsetzung : In einer retrospektiven Studie untersuchten wir die Ergebnisse der okzipitozervikalen Fusion mit der Y-Platte bei 39 Patienten ( 32 Frauen und 7 Maenner ) mit chronischer Polyarthritis , die zwischen 1987 und 1994 an der Schulthess-Klinik Zuerich mit einem Durchschnittsalter von 62,6 Jahren ( 47 bis 79 Jahre ) operiert wurden . Die Indikation zum chirurgischen Eingriff wurde bei Instabilitaet des okzipitozervikalen Uebergangs und in Faellen mit basilaerer Impression und/oder nach transoraler Densresektion gestellt , wobei die Ausdehnung der Fusion vom Ausmass der pathologischen Veraenderungen der mittleren und unteren Halswirbelsaeule abhing . Material : Praeoperativ klagten 35 Patienten ueber starke und 4 ueber mittelstarke Schmerzen im Nacken und/oder Hinterkopf , die auf einer linearen Skala von 0 bis 10 mit durchschnittlich 8,1 ( 4 bis 10 ) beurteilt wurden . Bei 31 Patienten war eine atlantoaxiale Instabilitaet und bei 19 Patienten eine basilaere Impression des Dens in das Foramen magnum vorhanden . Eine zervikale Myelopathie wurde in 20 Faellen diagnostiziert . Die Fusion erfolgte vom Occiput bis C2 in 22 , bis C3-C5 in 8 und bis C7-Th2 in 9 Faellen . Bei 13 Patienten wurde vor der dorsalen Stabilisierung eine transorale Densresektion durchgefuehrt . Ergebnisse : 32 Patienten konnten mit einem Mindestzeitraum von 12 Monaten ( durchschnittlich 32,2 Monate , Minimum 12 Monate , Maximum 66 Monate ) nachkontrolliert werden . Nach den Kriterien von Conaty wurde in 24 Faellen ( 75% ) ein befriedigendes und in 8 Faellen ( 25% ) ein unbefriedigendes Resultat erzielt . Zum Nachkontrollzeitpunkt wurde der Schmerz mit durchschnittlich 2,3 ( 0 bis 10 ) angegeben . Eine Myelopathie war bei 2 Patienten vorhanden . Bei 6 Patienten wurden weitere Operationen an der Halswirbelsaeule noetig . Bei 4 Patienten musste die Fusion nach kaudal verlaengert werden , da eine Instabilitaet in den Segmenten unterhalb der Spondylodese aufgetreten war . Die Fusionsrate betrug 96,9% , obwohl es bei 3 Patienten zu einem Plattenbruch und bei 2 zu einer Schraubenlockerung gekommen war . Schlussfolgerung : Die Ergebnisse zeigen die Effektivitaet der okzipitozervikalen Fusion bei Patienten mit chronischer Polyarthritis . Eine transorale Dekompression halten wir nur bei den Faellen fuer indiziert , in denen eine durch den Dens axis oder das retrodentale Pannusgewebe hervorgerufene Kompression des Myelons nicht durch eine Extension behoben werden kann oder in denen eine basilaere Impression mit Myelonkompression vorliegt ." ], "offsets": [ [ 0, 2549 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 131, 140 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 146, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Maenner" ], "offsets": [ [ 159, 166 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025266" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 185, 198 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "chronischer Polyarthritis" ], "offsets": [ [ 173, 198 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Halswirbelsaeule" ], "offsets": [ [ 640, 656 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Halswirbelsaeule" ], "offsets": [ [ 640, 656 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037949" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 701, 710 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 749, 758 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 897, 906 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 955, 964 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Foramen magnum" ], "offsets": [ [ 1007, 1021 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016519" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Myelopathie" ], "offsets": [ [ 1049, 1060 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037928" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1197, 1206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1307, 1316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Schmerz" ], "offsets": [ [ 1643, 1650 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Myelopathie" ], "offsets": [ [ 1706, 1717 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037928" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s11-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1728, 1737 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s12-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1756, 1765 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s12-t2", "type": "umlsterm", "text": [ "Halswirbelsaeule" ], "offsets": [ [ 1800, 1816 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027530" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s12-t3", "type": "umlsterm", "text": [ "Halswirbelsaeule" ], "offsets": [ [ 1800, 1816 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037949" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s13-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1832, 1841 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s13-t2", "type": "umlsterm", "text": [ "Spondylodese" ], "offsets": [ [ 1946, 1958 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0600339" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s14-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 2024, 2033 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s14-t2", "type": "umlsterm", "text": [ "Plattenbruch" ], "offsets": [ [ 2043, 2055 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005971" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s15-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 2202, 2211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s15-t2", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 2228, 2241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s15-t3", "type": "umlsterm", "text": [ "chronischer Polyarthritis" ], "offsets": [ [ 2216, 2241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "type": "umlsterm", "text": [ "Dekompression" ], "offsets": [ [ 2260, 2273 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011117" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "type": "umlsterm", "text": [ "axis" ], "offsets": [ [ 2351, 2355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004457" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "type": "umlsterm", "text": [ "Extension" ], "offsets": [ [ 2447, 2456 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040597" } ] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t4", "type": "umlsterm", "text": [ "Dens axis" ], "offsets": [ [ 2346, 2355 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028881" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r1-t4.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t4", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r2-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t4", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r3-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r4-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r5-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r6-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t4", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r7-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r8-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s1-r9-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s2-r1-t2.1-t1.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s2-r2-t1.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s11-r1-t1.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s12-r1-t2.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s12-r2-t3.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s13-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s13-r2-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s14-r1-t1.1-t2.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s15-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s16-r1-t4.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t4", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s16-r2-t2.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570147.ger.abstr-s16-r3-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570147.ger.abstr-s16-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570159.ger.abstr-passage-0", "type": "abstract", "text": [ "Bei der Katzenkratzkrankheit ( KKK ) handelt es sich um eine in Deutschland wenig bekannte Infektionskrankheit . Erst vor wenigen Jahren konnte der Erreger , Bartonella henselae , isoliert werden . In der Mehrzahl der Faelle findet sich ein typisches Krankheitsbild mit Hautveraenderungen im Bereich von Katzenbiss- oder Kratzwunden und einer benignen Lymphadenopathie . Weniger haeufig kommt es zu weiteren Organmanifestationen . Wir berichten ueber eine 47-jaehrige Patientin , die nach einem Katzenbiss eine reaktive Spondarthritis mit Synovialitiden der Fingergelenke , Polyarthralgien der mittleren und grossen Gelenke und entzuendliche Lumbalgien entwickelte . Die rheumatische Symptomatik war zeitlich limitiert und sprach gut auf NSAR an . Bislang sind nur wenige Faelle von Gelenkbeteiligung im Rahmen einer KKK beschrieben worden . Da die Durchseuchung von Katzen mit Bartonella henselae in Europa jedoch hoch ist , koennte es sich um eine haeufigere Ursache von Gelenkbeschwerden handeln , als bislang angenommen . Die Diagnostik der KKK wurde in den letzten Jahren durch die Entwicklung serologischer Teste erleichtert . Wir geben einen Ueberblick ueber die klinischen Manifestationen und fassen die diagnostischen Kriterien dieser Erkrankung zusammen ." ], "offsets": [ [ 0, 1265 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570159.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Katzenkratzkrankheit" ], "offsets": [ [ 8, 28 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007361" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Deutschland" ], "offsets": [ [ 64, 75 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Infektionskrankheit" ], "offsets": [ [ 91, 110 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009450" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Bartonella" ], "offsets": [ [ 158, 168 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004770" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Bartonella henselae" ], "offsets": [ [ 158, 177 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242631" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Hautveraenderungen" ], "offsets": [ [ 270, 288 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037274" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Hautveraenderungen" ], "offsets": [ [ 270, 288 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Katzenbiss-" ], "offsets": [ [ 304, 315 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007450" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Lymphadenopathie" ], "offsets": [ [ 352, 368 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024228" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Katzenbiss" ], "offsets": [ [ 495, 505 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007450" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Fingergelenke" ], "offsets": [ [ 558, 571 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016125" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 616, 623 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Gelenkbeteiligung" ], "offsets": [ [ 783, 800 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Katzen" ], "offsets": [ [ 867, 873 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007450" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Bartonella" ], "offsets": [ [ 878, 888 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004770" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Europa" ], "offsets": [ [ 901, 907 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015176" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t4", "type": "umlsterm", "text": [ "Gelenkbeschwerden" ], "offsets": [ [ 973, 990 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t5", "type": "umlsterm", "text": [ "Bartonella henselae" ], "offsets": [ [ 878, 897 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0242631" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Diagnostik" ], "offsets": [ [ 1030, 1040 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" } ] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "serologischer Teste" ], "offsets": [ [ 1099, 1118 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036743" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570159.ger.abstr-s1-r1-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s1-r2-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s1-r3-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s1-r4-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r1-t4.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r2-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r3-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r4-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r5-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r6-t1.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r7-t2.1-t3.1", "type": "property_of", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r8-t2.1-t3.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r9-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s3-r10-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-r2-t1.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-r3-t5.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s8-r4-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570159.ger.abstr-s9-r1-t2.1-t1.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.80570159.ger.abstr-s9-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570207.ger.abstr-passage-0", "type": "abstract", "text": [ "Der Einsatz von Antioxidantien , und hierbei vor allem Vitamin E , als Therapeutikum hat in den vergangen Jahren zunehmendes Interesse gefunden . Dieses Interesse gilt auch verschiedenen rheumatischen Erkrankungen wie der chronischen Polyarthritis und Osteoarthrose . Dabei ist dieser Ansatz bei weitem nicht neu , und erste Fallbeschreibungen ueber einen positiven Effekt von Vitamin E in der Behandlung degenerativer Erkrankungen reichen ueber 30 Jahre zurueck . Doch viele der nachfolgenden Studien genuegen in keiner Weise wissenschaftlichen Guetekriterien , so dass der breite Einsatz von Vitamin E zurecht eher kritisch betrachtet wurde . Neuerliche epidemiologische und klinische Untersuchungen lassen jedoch zunehmend vermuten , dass Vitamin E in der Behandlung des Schmerzes bei chronischer Polyarthritis und Arthrose durchaus wirksam ist . In dieser Arbeit geben wir eine Zusammenfassung der wissenschaftlichen Studien ueber die Wirksamkeit von Vitamin E bei rheumatischen Erkrankungen und beschreiben potentielle Wirkmechanismen ." ], "offsets": [ [ 0, 1041 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570207.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 55, 62 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Vitamin E" ], "offsets": [ [ 55, 64 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042874" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 234, 247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "chronischen Polyarthritis" ], "offsets": [ [ 222, 247 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 377, 384 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 394, 404 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Vitamin E" ], "offsets": [ [ 377, 386 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042874" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 594, 601 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Vitamin E" ], "offsets": [ [ 594, 603 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042874" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 742, 749 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 759, 769 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Schmerzes" ], "offsets": [ [ 774, 783 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 800, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Arthrose" ], "offsets": [ [ 818, 826 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022408" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "Vitamin E" ], "offsets": [ [ 742, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042874" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t7", "type": "umlsterm", "text": [ "chronischer Polyarthritis" ], "offsets": [ [ 788, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Arbeit" ], "offsets": [ [ 860, 866 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 955, 962 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Vitamin E" ], "offsets": [ [ 955, 964 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042874" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570207.ger.abstr-s1-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s1-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s3-r1-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s3-r2-t2.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s3-r3-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s4-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s4-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r1-t2.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r2-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r3-t6.1-t7.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r4-t6.1-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r5-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r6-t1.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r7-t6.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r8-t6.1-t4.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r9-t3.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r10-t2.1-t6.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r11-t6.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r12-t1.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r13-t2.1-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r14-t6.1-t7.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s5-r15-t1.1-t7.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s5-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s6-r1-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570207.ger.abstr-s6-r2-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570207.ger.abstr-s6-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570215.ger.abstr-passage-0", "type": "abstract", "text": [ "In einem randomisierten , doppelblinden Parallelgruppenvergleich wurde die Wirksamkeit und Vertraeglichkeit von hochdosiertem Vitamin E ( 3x400mg RRR--Tocopherolacetat/d) gegen Diclofenac-Natrium ( 3x50mg/d) bei stationaeren Patienten mit gesicherter chronischer Polyarthritis geprueft . Nach einer dreiwoechigen Behandlung war sowohl unter der Vitamin E-Therapie n=42) als ( auch unter der Behandlung mit Diclofenac ( n=43) eine deutliche Besserung aller untersuchten klinischen Parameter zu beobachten . Die Dauer der Morgensteifigkeit verringerte sich unter der Vitamin E-Therapie von 90min auf 68min , unter der Diclofenac-Einnahme von 68min auf 30min . Der Gelenk-Index nach Ritchie ging von 56 auf 46 ( Vitamin E ) bzw. von 49 auf 34 ( Diclofenac ) zurueck . Die Griffstaerke erhoehte sich sowohl in der Vitamin-E-Gruppe als auch in der Diclofenac-Gruppe . Ebenso war in beiden Gruppen eine deutliche Verringerung des Schweregrades der Schmerzen , beurteilt anhand einer 10cm visuellen Analogskala zu beobachten . Das Gesamturteil von Arzt und Patient zum Therapieerfolg fiel fuer die beiden Arzneimittel aehnlich positiv aus . Insbesondere vor dem Hintergrund des Risikoprofils der NSAR in der Langzeitbehandlung der chronischen Polyarthritis stellt die Einnahme von hochdosiertem Vitamin E eine moegliche Alternative in der Behandlung entzuendlich rheumatischer Erkrankungen dar ." ], "offsets": [ [ 0, 1388 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "doppelblinden" ], "offsets": [ [ 26, 39 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525065" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 126, 133 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Diclofenac-Natrium" ], "offsets": [ [ 177, 195 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0700583" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 225, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 263, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Vitamin E" ], "offsets": [ [ 126, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042874" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t7", "type": "umlsterm", "text": [ "stationaeren Patienten" ], "offsets": [ [ 212, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021562" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "type": "umlsterm", "text": [ "chronischer Polyarthritis" ], "offsets": [ [ 251, 276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 313, 323 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 345, 352 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 391, 401 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Diclofenac" ], "offsets": [ [ 406, 416 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012091" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 565, 572 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Gelenk-Index" ], "offsets": [ [ 662, 674 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 709, 716 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Diclofenac" ], "offsets": [ [ 742, 752 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012091" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Vitamin E" ], "offsets": [ [ 709, 718 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042874" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Griffstaerke" ], "offsets": [ [ 769, 781 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0220843" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Griffstaerke" ], "offsets": [ [ 769, 781 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038179" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 942, 951 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Arzt" ], "offsets": [ [ 1041, 1045 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Patient" ], "offsets": [ [ 1050, 1057 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Therapieerfolg" ], "offsets": [ [ 1062, 1076 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085415" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Therapieerfolg" ], "offsets": [ [ 1062, 1076 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-t5", "type": "umlsterm", "text": [ "Arzneimittel" ], "offsets": [ [ 1098, 1110 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013227" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Langzeitbehandlung" ], "offsets": [ [ 1201, 1219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Langzeitbehandlung" ], "offsets": [ [ 1201, 1219 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 1236, 1249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "type": "umlsterm", "text": [ "Vitamin" ], "offsets": [ [ 1288, 1295 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042890" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 1332, 1342 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "type": "umlsterm", "text": [ "chronischen Polyarthritis" ], "offsets": [ [ 1224, 1249 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "type": "umlsterm", "text": [ "Vitamin E" ], "offsets": [ [ 1288, 1297 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042874" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r1-t8.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r2-t5.1-t8.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r3-t3.1-t5.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r4-t8.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r5-t5.1-t7.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r6-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r7-t8.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r8-t3.1-t8.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r9-t8.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r10-t2.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r11-t8.1-t7.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r12-t5.1-t8.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r13-t5.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r14-t5.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r15-t2.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r16-t5.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r17-t2.1-t8.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r18-t3.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r19-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r20-t5.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r21-t3.1-t8.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r22-t3.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s1-r23-t5.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s2-r1-t4.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s2-r2-t3.1-t4.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s2-r3-t1.1-t4.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s2-r4-t2.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-r1-t3.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-r3-t4.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-r4-t4.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-r5-t2.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s4-r6-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-r1-t3.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-r2-t1.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-r3-t1.1-t2.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-r4-t2.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-r5-t4.1-t4.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-r6-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t4", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s7-r7-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r1-t3.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r2-t2.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r3-t5.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r4-t7.1-t3.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r5-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r6-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r7-t7.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r8-t6.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r9-t5.1-t7.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r10-t2.1-t7.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r11-t7.1-t6.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r12-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r13-t3.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r14-t6.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r15-t6.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r16-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r17-t6.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r18-t3.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r19-t7.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570215.ger.abstr-s8-r20-t7.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t7", "arg2_id": "ZfuerRheumatologie.80570215.ger.abstr-s8-t6", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570285.ger.abstr-passage-0", "type": "abstract", "text": [ "Wir beschreiben den Fall eines 55-jaehrigen Patienten mit seit 5 Jahren bestehenden Kniegelenkerguessen beidseits , der uns zur Radiosynoviorthese zugewiesen wurde . Klinisch und laborchemisch ergaben sich zunaechst keine Anhaltspunkte fuer eine entzuendlich rheumatische Erkrankung . Weder Radiosynoviorthese noch offene Synovektomie mit partiellem Kniegelenkersatz des rechten Knies fuehrten zu einem Rueckgang der Ergussbildung . Ein Jahr spaeter wurde anlaesslich einer Harnleiteroperation die Diagnose eines Morbus Ormond gestellt . Die histologischen Studien von Kniegelenkssynovialmembran und Retroperitonealgewebe zeigten vergleichbare Strukturen . Die Diagnose einer seronegativen Oligoarthritis mit retroperitonealer Rheumaknotenbildung und Ausbildung eines sekundaeren Morbus Ormond war damit wahrscheinlich . Unter einer immunsuppressiven Therapie mit Azathioprin haben sich die retroperitonealen Rheumaknoten vollstaendig zurueckgebildet , die erforderlichen Kniegelenkspunktionen deutlich abgenommen ." ], "offsets": [ [ 0, 1015 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570285.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 44, 53 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Kniegelenkerguessen" ], "offsets": [ [ 84, 103 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Kniegelenkersatz" ], "offsets": [ [ 350, 366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Harnleiteroperation" ], "offsets": [ [ 474, 493 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041951" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Diagnose" ], "offsets": [ [ 498, 506 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Diagnose" ], "offsets": [ [ 661, 669 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Ausbildung" ], "offsets": [ [ 751, 761 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013622" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 851, 859 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Azathioprin" ], "offsets": [ [ 864, 875 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004482" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Kniegelenkspunktionen" ], "offsets": [ [ 972, 993 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022745" } ] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Kniegelenkspunktionen" ], "offsets": [ [ 972, 993 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034117" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-r1-t4.1-t1.1", "type": "precedes", "arg1_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-r2-t4.1-t1.2", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-r3-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-r5-t4.1-t1.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570285.ger.abstr-s7-r6-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.80570285.ger.abstr-s7-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570294.ger.abstr-passage-0", "type": "abstract", "text": [ "In kontrollierten klinischen Studien zur Wirksamkeit und Vertraeglichkeit von verschiedenen monoklonalen anti-TNF-Antikoerpern und sTNFR-IgG-Fusionsproteinen bei rheumatoider Arthritis wurde nachgewiesen , dass die systemische und synoviale Blockierung der TNF-Aktivitaet eine tiefgreifende und langhaltende Wirkung auf die Symptome der Erkrankung hat . Die parenterale Verabreichung ( i.v. oder s.c. ) von Einzelgaben und wiederholte Applikationen ueber mehrere Wochen/Monate haben einen signifikanten dosis-abhaengigen Effekt auf klinische Wirksamkeitsparameter ( Gelenk-Schwellung und -Druckempfindlichkeit ) sowie auf ESR und CRP . Aus Untersuchungen zur Rolle von TNF und anderer pro-inflammatorischer Zytokine bei Synovitis und Gelenkdestruktion sowie zum immunpharmakologischen Profil von anti-TNF-Therapien laesst sich schliessen , dass durch Blockierung/Neutralsation von TNF wichtige an der Pathogenese beteiligte Effektormechanismen moduliert werden koennen . Die Hemmung der durch pro-inflammatorische Zytokine induzierten Bildung pro-inflammatorischer Mediatoren vom Typ der Prostanoide und Leukotriene fuehrt zur Verringerung von Schmerz , Schwellung und Druckempfindlichkeit . Durch Modulierung der zytokin-abhaengigen Aktivitaet der Adhaesionsmolekuele ICAM-1 und ELAM-1 in Endothelzellen und Synoviozyten wird die trans-endothelialen Praesentation von Entzuendungszellen und Immunzellen blockiert . Der signifikante Effekt von anti-TNF-Therapien auf die zur Matrixdegradation fuehrende Freisetzung von Metalloproteinasen hat das Potential , destruktive Gelenkveraenderungen im Verlaufe einer Langzeitbehandlung zu verlangsamen oder zu verhindern ." ], "offsets": [ [ 0, 1664 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570294.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 175, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "rheumatoider Arthritis" ], "offsets": [ [ 162, 184 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Gelenk-Schwellung" ], "offsets": [ [ 566, 583 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "-Druckempfindlichkeit" ], "offsets": [ [ 588, 609 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 659, 664 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Zytokine" ], "offsets": [ [ 707, 715 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079189" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Synovitis" ], "offsets": [ [ 720, 729 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039103" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Gelenkdestruktion" ], "offsets": [ [ 734, 751 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Zytokine" ], "offsets": [ [ 1014, 1022 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0079189" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Leukotriene" ], "offsets": [ [ 1104, 1115 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023545" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Schmerz" ], "offsets": [ [ 1144, 1151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Druckempfindlichkeit" ], "offsets": [ [ 1169, 1189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033095" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "ICAM-1" ], "offsets": [ [ 1269, 1275 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0063695" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "ELAM-1" ], "offsets": [ [ 1280, 1286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0115305" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Endothelzellen" ], "offsets": [ [ 1290, 1304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014257" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Endothelzellen" ], "offsets": [ [ 1290, 1304 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Immunzellen" ], "offsets": [ [ 1392, 1403 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007634" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Gelenkveraenderungen" ], "offsets": [ [ 1570, 1590 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Langzeitbehandlung" ], "offsets": [ [ 1609, 1627 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Langzeitbehandlung" ], "offsets": [ [ 1609, 1627 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570294.ger.abstr-s2-r1-t2.1-t1.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-r1-t4.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-r2-t2.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-r3-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-r4-t2.1-t3.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s3-r5-t3.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s4-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s4-r2-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r1-t3.1-t4.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r2-t4.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r3-t1.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r4-t5.1-t3.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r5-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r6-t5.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r7-t2.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r8-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r9-t3.1-t5.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r10-t1.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r11-t4.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r12-t1.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r13-t2.1-t5.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r14-t3.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r15-t5.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r16-t2.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r17-t4.1-t3.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s5-r18-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570294.ger.abstr-s6-r1-t1.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570294.ger.abstr-s6-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570302.ger.abstr-passage-0", "type": "abstract", "text": [ "Ziel der folgenden Studien war die Dosisoptimierung fuer eine Therapie der chronischen Polyarthritis mit TNFR55-IgG1 durch Erfassung der Wirksamkeit , Sicherheit , Vertraeglichkeit und Pharmakokinetik . Methode : In zwei doppelblinden , placebokontrollierten , multizentrischen Studien ( Europa und USA ) wurden insgesamt 218 Patienten mit refraktaerer , florider chronischer Polyarthritis nach Auswaschen der Basistherapeutika bei gleichbleibender Dosis von NSAR und ggf. Steroiden mit monatlich i.v. Placebo , 0,01 , 0,05 , 0,2 oder 0,5mg/kg TNFR55-IgG1 behandelt . In einer weiteren deutschen Studie wurde eine Erhaltungstherapie von 14taetig 20mg TNFR55-IgG1 i.v. verglichen mit einer monatlichen Gabe von 50mg . Zuvor hatten die 60 Patienten in dieser Studie eine initale Dosis von 100mg erhalten . Ergebnis : In allen drei Studien zeigten Patienten , die mit TNFR55-IgG1 behandelt wurden , eine rasche und deutlische Besserung aller gemessenen Parameter bereits einen Tag nach der ersten Gabe . Das Maximum des therapeutischen Effektes war von der Dosis abhaengig und wurde nach zwei Wochen erreicht . Nachfolgend kam es trotz der weiteren Gabe der Pruefsubstanz zu einem Anstieg der Entzuendungsparameter . Parallel konnten anti-TNFR55-IgG1 Antikoerper nachgewiesen werden , die die Clearance der Pruefsubstanz beschleunigten . Die Pruefsubstanz wurde in den drei Studien gut vertragen . Diskussion : Intravenoeses TNFR55-IgG1 war rasch wirksam und gut vertraeglich bei Patienten mit therapierefraktaerer \" chronischer Polyarthritis . \" Mit den geprueften Therapieschemata konnte aber die initial erreichte Besserung nicht aufrecht erhalten werden ." ], "offsets": [ [ 0, 1656 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 62, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 87, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Sicherheit" ], "offsets": [ [ 151, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036043" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Pharmakokinetik" ], "offsets": [ [ 185, 200 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031327" }, { "db_name": "UMLS", "db_id": "C0031328" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "chronischen Polyarthritis" ], "offsets": [ [ 75, 100 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Methode" ], "offsets": [ [ 203, 210 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "doppelblinden" ], "offsets": [ [ 221, 234 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525065" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "placebokontrollierten" ], "offsets": [ [ 237, 258 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Europa" ], "offsets": [ [ 288, 294 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015176" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "USA" ], "offsets": [ [ 299, 302 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041703" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 326, 335 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 376, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t8", "type": "umlsterm", "text": [ "Steroiden" ], "offsets": [ [ 473, 482 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t9", "type": "umlsterm", "text": [ "Placebo" ], "offsets": [ [ 502, 509 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032042" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "type": "umlsterm", "text": [ "chronischer Polyarthritis" ], "offsets": [ [ 364, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 737, 746 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 845, 854 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Antikoerper" ], "offsets": [ [ 1248, 1259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1477, 1486 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "therapierefraktaerer" ], "offsets": [ [ 1491, 1511 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t3", "type": "umlsterm", "text": [ "Polyarthritis" ], "offsets": [ [ 1526, 1539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162323" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "type": "umlsterm", "text": [ "chronischer Polyarthritis" ], "offsets": [ [ 1514, 1539 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Therapieschemata" ], "offsets": [ [ 1563, 1579 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r1-t4.1-t4.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r2-t2.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r4-t4.2-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r5-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r6-t4.2-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r7-t1.2-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r8-t2.1-t1.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r9-t1.2-t4.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r10-t1.1-t4.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r11-t4.1-t1.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r12-t4.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r13-t4.2-t1.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r15-t1.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r16-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s1-r17-t1.2-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r1-t1.2-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r2-t9.1-t7.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t9", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r3-t5.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r4-t6.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r5-t4.1-t10.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r6-t7.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r7-t3.1-t10.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r8-t6.1-t1.2", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r9-t5.1-t10.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r10-t7.1-t10.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r11-t1.2-t9.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r12-t3.1-t7.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r13-t6.1-t9.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r14-t1.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r15-t10.1-t1.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r16-t7.1-t1.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r17-t4.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r18-t10.1-t6.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r19-t7.1-t6.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r20-t10.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r21-t9.1-t10.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t9", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r22-t10.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r24-t7.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r25-t6.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r26-t7.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t7", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r27-t1.1-t10.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s2-r28-t10.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s2-t10", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-r2-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-r3-t2.2-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-r4-t3.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-r6-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-r7-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t3", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570302.ger.abstr-s10-r8-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570302.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570302.ger.abstr-s11-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570307.ger.abstr-passage-0", "type": "abstract", "text": [ "Ziel : Beurteilung der langfristigen Sicherheit , Vertraeglichkeit und Wirksamkeit einer Therapie mit einem Tumornekrosefaktor alpha p55 Rezeptor IgG1 Fusionsprotein ( TNFR55-IgG1) am eigenen Kollektiv . Methode : 80 Patienten mit florider , refraktaerer , langjaehriger cP wurden von uns in Phase II Studien eingebracht und ueber 2 bis 30 Monate mit monatlich 2,5 bis 100mg TNFR55-IgG1 therapiert . Die kumulative Dosis betrug 40-940mg. Krankheitsaktivitaet ( Zahl geschwollener Gelenke , Blutsenkung , C-reaktives Protein ) , Therapie und Nebenwirkungen wurden dokumentiert . Ferner wurde die Pharmakokinetik , der anti-TNFR55-IgG1 Antikoerper- und der TNF Spiegel nach der ersten und dritten Injektion bestimmt . Ergebnis : 80 Patienten konnten kumulativ 170 Patientenjahre dokumentiert werden . Fuenf Patienten ( 6% ) sind an ihrer kardiovaskulaeren Grunderkrankung verstorben , davon einer unter Therapie . Ein weiterer Patient starb 6 Monate nach Beendigung der Studie an einer septischen Arthritis nach auswaertiger intraartikulaerer Corticosteroid-Injektion . 11 Patienten werden weiterhin mit TNFR55-IgG1 therapiert . Haeufige Begleiterscheinungen unter der Therapie waren myalgiforme Beschwerden . Eine Patientin mit erosiver cP ( ANA und anti-dsDNS positiv bereits vor TNFR55-IgG1) entwickelte eine Lupusnephritis 18 Monate nach der letzten Injektion des TNFR55-IgG1. Anti-TNFR55-IgG1 Antikoerper korrelierten mit einer Verkuerzung der Halbwertszeit . Veraenderungen der Glykosylierung des Fusionsproteins beeinflussten Pharmakokinetik und Effektivitaet der Therapie . 9 Patienten zeigten eine anhaltende deutliche Besserung auch 2 Jahre nach der letzten Injektion . Durch eine ueber 30 Monate fortgesetzte Therapie konnte bei 11 Patienten eine Reduktion der Zahl geschwollener Gelenke um 81% erreicht werden ." ], "offsets": [ [ 0, 1821 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Beurteilung" ], "offsets": [ [ 7, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Sicherheit" ], "offsets": [ [ 37, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036043" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 89, 97 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Tumornekrosefaktor" ], "offsets": [ [ 108, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027651" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Tumornekrosefaktor" ], "offsets": [ [ 108, 126 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027540" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Methode" ], "offsets": [ [ 204, 211 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 217, 226 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 480, 487 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Blutsenkung" ], "offsets": [ [ 490, 501 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005833" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Protein" ], "offsets": [ [ 516, 523 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033684" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 528, 536 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Pharmakokinetik" ], "offsets": [ [ 595, 610 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031327" }, { "db_name": "UMLS", "db_id": "C0031328" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Antikoerper-" ], "offsets": [ [ 634, 646 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Injektion" ], "offsets": [ [ 695, 704 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 730, 739 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Patientenjahre" ], "offsets": [ [ 762, 776 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 805, 814 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 901, 909 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Patient" ], "offsets": [ [ 925, 932 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 995, 1004 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Corticosteroid-Injektion" ], "offsets": [ [ 1041, 1065 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0001617" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Corticosteroid-Injektion" ], "offsets": [ [ 1041, 1065 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "type": "umlsterm", "text": [ "septischen Arthritis" ], "offsets": [ [ 984, 1004 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003874" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1071, 1080 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 1167, 1175 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Lupusnephritis" ], "offsets": [ [ 1310, 1324 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024143" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "Injektion" ], "offsets": [ [ 1352, 1361 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s10-t3", "type": "umlsterm", "text": [ "Antikoerper" ], "offsets": [ [ 1396, 1407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Pharmakokinetik" ], "offsets": [ [ 1531, 1546 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031327" }, { "db_name": "UMLS", "db_id": "C0031328" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s11-t2", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 1569, 1577 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s12-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1582, 1591 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s12-t2", "type": "umlsterm", "text": [ "Injektion" ], "offsets": [ [ 1666, 1675 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021485" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 1718, 1726 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1741, 1750 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "type": "umlsterm", "text": [ "Gelenke" ], "offsets": [ [ 1789, 1796 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r1-t5.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r2-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r3-t3.2-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r4-t1.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r5-t5.1-t3.2", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r6-t5.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r7-t2.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r8-t2.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r9-t3.2-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r10-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r11-t3.2-t5.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r12-t1.1-t3.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r13-t3.2-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r14-t1.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r15-t3.1-t3.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r16-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s1-r17-t2.1-t3.2", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s3-r1-t2.1-t3.1", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s3-r2-t2.1-t4.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s3-r3-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s4-r1-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s6-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s6-r2-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r2-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r3-t1.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r4-t5.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r5-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r6-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r7-t5.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r8-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r9-t3.1-t5.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r10-t4.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s7-r11-t5.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s10-r1-t3.1-t1.1", "type": "indicates", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s10-r2-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s10-r3-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s10-r4-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s12-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570307.ger.abstr-s13-r1-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t3", "arg2_id": "ZfuerRheumatologie.80570307.ger.abstr-s13-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570320.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Hypothese von der rheumatoiden Arthritis ( RA ) als T-Zell-vermittelter Erkrankung hat zur Entwicklung zahlreicher Therapieansaetze gefuehrt , welche auf die Modulation der Funktion aktivierter T-Zellen gerichtet sind . An die Behandlung der RA mit Antikoerpern gegen das CD4-Molekuel auf T-Zell-Oberflaechen haben sich Hoffnungen auf einen therapeutischen Durchbruch geknuepft . Nach guten Ergebnissen in offenen Studien haben Doppelblindversuche den Nachweis der Wirksamkeit dieser Therapie jedoch bisher nicht erbringen koennen . Die Gruende fuer dieses Scheitern sind vielfaeltig und beinhalten neben grundsaetzlichen Zweifeln an der T-Zell-Hypothese der RA auch Schwierigkeiten beim Studiendesign und pharmakologische Probleme . Eine endgueltige Bewertung der Wirksamkeit einer anti-CD4-Therapie wird erst nach Abschluss von Studien mit nichtdepletierenden anti-CD4-Antikoerpern moeglich sein ." ], "offsets": [ [ 0, 903 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 35, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Therapieansaetze" ], "offsets": [ [ 119, 135 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "T-Zellen" ], "offsets": [ [ 198, 206 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039194" } ] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 22, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 231, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Antikoerpern" ], "offsets": [ [ 253, 265 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003241" } ] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Doppelblindversuche" ], "offsets": [ [ 432, 451 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525065" } ] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 488, 496 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-r1-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570320.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-r2-t2.2-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.80570320.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-r3-t2.2-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-r4-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-r6-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s1-r7-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.80570320.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s3-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570320.ger.abstr-s3-r2-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.80570320.ger.abstr-s3-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570330.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Verpflichtung der Selbstverwaltung zur Qualitaetssicherung ist im deutschen Sozialrecht festgelegt . Die konkreten Wege zur Umsetzung dieser Verpflichtung werden von den Selbstverwaltungspartnern in eigener Verantwortung vereinbart und realisiert . Die Einfuehrung pauschalierter Verguetungsformen hat die steigende Bedeutung der Qualitaetssicherung als Wettbewerbsparameter deutlich gemacht . Um dieser steigenden Bedeutung gerecht zu werden , gibt die Gesundheitspolitik der Selbstverwaltung Hilfestellung durch die Foerderung von Modellvorhaben . Diese haben ihr Schwergewicht in juengster Zeit vermehrt auf global wirkende Ansaetze des umfassenden Qualitaetsmanagements gelegt ." ], "offsets": [ [ 0, 686 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570330.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Gesundheitspolitik" ], "offsets": [ [ 458, 476 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0018735" } ] }, { "id": "ZfuerRheumatologie.80570330.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Zeit" ], "offsets": [ [ 597, 601 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] } ]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.80570335.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Bedeutung der Begriffe \" Qualitaet Versorgungsqualitaet \" und \" Qualitaetsmanagement \" \" , \" wird anhand international gebraeuchlicher Definitionen geklaert . Daran anknuepfend werden Leitgedanken Konzepte und Ziele , eines Qualitaetsmanagements in der Medizin erlaeutert . Abschliessend folgt ein Ausblick auf qualitaetsbezogene Zukunftstrends , welche Herausforderungen fuer die aerztliche Profession und die Medizin insgesamt darstellen ." ], "offsets": [ [ 0, 445 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570335.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Medizin" ], "offsets": [ [ 257, 264 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025118" } ] }, { "id": "ZfuerRheumatologie.80570335.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Medizin" ], "offsets": [ [ 415, 422 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025118" } ] } ]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.80570340.ger.abstr-passage-0", "type": "abstract", "text": [ "Begriffe wie \" Kostensenkung \" , \" Kosteneffizienz Wirtschaftlichkeit \" oder \" Verbesserung \" , \" der Ressourcenallokation \" sind zentrale Begriffe in der aktuellen gesundheitspolitischen Diskussion . Dagegen wird der Terminus \" Rationierung \" weitgehend vermieden . Unverkennbar stellt die implizite Rationierung ( z.B. bei der Festlegung von Gesamtbudgets fuer Gesundheitsausgaben oder bei der Festlegung von Niederlassungssperren fuer Fachaerzte ) jedoch eine allgegenwaertige Gestaltungsgeste im deutschen Gesundheitswesen dar . Nur in geringem Masse stuetzen sich Rationierungsentscheidungen bislang auf empirische Grundlagen . Eine wesentliche Aufgabe der Wissenschaft ist die Bereitstellung von Daten zu Kosten und Effekten medizinischer Interventionen im Rahmen soziooekonomischer Untersuchungen . Mit Hilfe entscheidungsanalytischer Verfahren lassen sich diese Daten fuer konkrete Entscheidungsprozesse aufbereiten . Auf Ebene der Wissenschaft ist hierfuer eine Zusammenfuehrung klinischer und oekonomischer Kompetenzen von herausragender Bedeutung . Dagegen sind seitens der Forschungsfoerderer oeffentlich getragene Projekte , die der Komplexitaet soziooekonomischer Fragestellungen in der medizinischen Versorgung Rechnung tragen , dringend erforderlich ." ], "offsets": [ [ 0, 1267 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570340.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Kosteneffizienz" ], "offsets": [ [ 35, 50 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013682" } ] }, { "id": "ZfuerRheumatologie.80570340.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Gesundheitsausgaben" ], "offsets": [ [ 363, 382 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015318" } ] }, { "id": "ZfuerRheumatologie.80570340.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Gesundheitswesen" ], "offsets": [ [ 510, 526 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525053" } ] }, { "id": "ZfuerRheumatologie.80570340.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Wissenschaft" ], "offsets": [ [ 662, 674 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036397" } ] }, { "id": "ZfuerRheumatologie.80570340.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Wissenschaft" ], "offsets": [ [ 940, 952 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036397" } ] }, { "id": "ZfuerRheumatologie.80570340.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "medizinischen Versorgung" ], "offsets": [ [ 1201, 1225 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011211" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570340.ger.abstr-s3-r1-t1.1-t2.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.80570340.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.80570340.ger.abstr-s3-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570351.ger.abstr-passage-0", "type": "abstract", "text": [ "Mit dem Curriculum \" Aerztliches Qualitaetsmanagement \" liegt seit 1996 ein dreistufiges Fortbildungkonzept vor . Gemaess dem auf dieser Basis entwickelten zielorientierten Kursangebot wurden bisher im ZQ vier Grundkurse , vier Stufe-II-Kurse und vier Stufe-III-Kurse durchgefuehrt . Damit sind inzwischen 50 Aerzte/innen fuer neue Rollen als Qualitaetsmanager im Krankenhaus qualifiziert . Die Ergebnisse der Teilnehmerbefragungen zeigen , dass das Konzept positiv bewertet wird - inzwischen auch von anderen Berufsgruppen im Gesundheitswesen . Nach nunmehr zweijaehriger Erfahrung steht eine Aktualisierung der Inhalte bevor , insbesondere vor dem Hintergrund neuer anstehender Qualitaetsdarlegungsmodelle fuer deutsche Krankenhaeuser ." ], "offsets": [ [ 0, 738 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570351.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Curriculum" ], "offsets": [ [ 8, 18 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010478" } ] }, { "id": "ZfuerRheumatologie.80570351.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Fortbildungkonzept" ], "offsets": [ [ 89, 107 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013626" } ] }, { "id": "ZfuerRheumatologie.80570351.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Rollen" ], "offsets": [ [ 332, 338 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.80570351.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Krankenhaus" ], "offsets": [ [ 364, 375 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": "ZfuerRheumatologie.80570351.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Teilnehmerbefragungen" ], "offsets": [ [ 410, 431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021822" } ] }, { "id": "ZfuerRheumatologie.80570351.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Berufsgruppen" ], "offsets": [ [ 510, 523 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027363" } ] }, { "id": "ZfuerRheumatologie.80570351.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Gesundheitswesen" ], "offsets": [ [ 527, 543 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525053" } ] }, { "id": "ZfuerRheumatologie.80570351.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Krankenhaeuser" ], "offsets": [ [ 722, 736 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570351.ger.abstr-s4-r1-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570351.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570351.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570351.ger.abstr-s4-r2-t2.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570351.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570351.ger.abstr-s5-t1", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570375.ger.abstr-passage-0", "type": "abstract", "text": [ "Waehrend des Lebens unterziehen sich Knorpel und Knochen in Anpassung an sich veraendernde Belastungsbedingungen einem Remodelling \" , \" welches normalerweise ein physiologisches Gleichgewicht zwischen Abbau und Neusynthese von Matrixkomponenten darstellt . Bei differenten Gelenkerkrankungen ist dieses Gleichgewicht zugunsten der Destruktion verschoben . Beim normalen \" turnover \" und gesteigert unter pathologischen Gelenkverhaeltnissen koennen intakte und framentierte Matrixbestandteile in die Synovialfluessigkeit , in das Blut und den Urin austreten und dort nachgewiesen werden . Eine Messung von Markern in der Synovia hat eine hoehere Gelenkspezifitaet , waehrend Serum- Plasma- oder Urinmessungen , eher den systemischen Stoffwechsel reflektieren . Der Forschungsprozess der letzten Jahre hat die Hoffnung bestaerkt , eventuell durch kombinierte Messungen mehrerer biochemischer Marker der Synthese und Destruktion des Knorpels und Knochens einen fruehen diagnostischen Zugang , eine vermehrte prognostische Aussagefaehigkeit und eine Hilfe in der Therapiekontrolle zu erhalten . Durch diese Markerstudien kann ein Beitrag zum besseren Verstaendnis des Knorpelmetabolismus und des Krankheitsmechanismus auf dem Gewebs- und Zellniveau geleistet werden . Es besteht die Notwendigkeit einer intensiven Forschung auf dem Gebiet der biochemischen Markersuche zur Nutzung im Bereich der Fruehdiagnostik , der Verlaufsbeurteilung , der Kontrolle der Entzuendungsaktivitaet sowie der Therapie- und Rehabilitationseffizienz bei degenerativen , traumatischen und entzuendlichen Gelenkerkrankungen , woran weltweit gearbeitet wird . Mit der Anwendung von biochemischen Markern wuerde besonders die klinische Pruefung verschiedener Therapieformen auf eine solidere Basis gestellt . Die gewebsspezifischen Marker des Knorpelmetabolismus versprechen in Zukunft nuetzliche Werkzeuge in der klinischen Anwendung zu werden , mit weiteren Moeglichkeiten fuer interessante Studien . Da die hauptsaechlichen Publikationen zu diesem Themenkreis in das Ende der achtziger und in die neunziger Jahre datieren , kann behauptet werden , dass die Forschung noch am Beginn steht ." ], "offsets": [ [ 0, 2165 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570375.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Lebens" ], "offsets": [ [ 13, 19 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0376558" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Knorpel" ], "offsets": [ [ 37, 44 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007301" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Knochen" ], "offsets": [ [ 49, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Gleichgewicht" ], "offsets": [ [ 179, 192 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014653" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Gelenkerkrankungen" ], "offsets": [ [ 274, 292 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Gleichgewicht" ], "offsets": [ [ 304, 317 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014653" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Gelenkverhaeltnissen" ], "offsets": [ [ 420, 440 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Synovialfluessigkeit" ], "offsets": [ [ 500, 520 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039097" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Blut" ], "offsets": [ [ 530, 534 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005767" }, { "db_name": "UMLS", "db_id": "C0005768" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Urin" ], "offsets": [ [ 543, 547 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Markern" ], "offsets": [ [ 606, 613 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Synovia" ], "offsets": [ [ 621, 628 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039097" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Gelenkspezifitaet" ], "offsets": [ [ 646, 663 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Gelenkspezifitaet" ], "offsets": [ [ 646, 663 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037791" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "Urinmessungen" ], "offsets": [ [ 695, 708 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-t6", "type": "umlsterm", "text": [ "Stoffwechsel" ], "offsets": [ [ 733, 745 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025519" }, { "db_name": "UMLS", "db_id": "C0025520" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Marker" ], "offsets": [ [ 891, 897 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Knorpels" ], "offsets": [ [ 931, 939 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007301" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Knochens" ], "offsets": [ [ 944, 952 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Aussagefaehigkeit" ], "offsets": [ [ 1020, 1037 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085732" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Therapiekontrolle" ], "offsets": [ [ 1060, 1077 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085421" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "Therapiekontrolle" ], "offsets": [ [ 1060, 1077 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t7", "type": "umlsterm", "text": [ "biochemischer Marker" ], "offsets": [ [ 877, 897 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206015" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Markerstudien" ], "offsets": [ [ 1104, 1117 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 1311, 1320 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Markersuche" ], "offsets": [ [ 1354, 1365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Fruehdiagnostik" ], "offsets": [ [ 1393, 1408 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Verlaufsbeurteilung" ], "offsets": [ [ 1415, 1434 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t5", "type": "umlsterm", "text": [ "Therapie-" ], "offsets": [ [ 1488, 1497 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "type": "umlsterm", "text": [ "Gelenkerkrankungen" ], "offsets": [ [ 1580, 1598 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Markern" ], "offsets": [ [ 1670, 1677 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Therapieformen" ], "offsets": [ [ 1732, 1746 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "biochemischen Markern" ], "offsets": [ [ 1656, 1677 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206015" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Marker" ], "offsets": [ [ 1805, 1811 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "type": "umlsterm", "text": [ "Publikationen" ], "offsets": [ [ 2000, 2013 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034036" } ] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 2133, 2142 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570375.ger.abstr-s1-r1-t3.1-t2.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s1-r2-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s1-r3-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s1-r4-t2.1-t3.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s2-r1-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-r1-t3.1-t2.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-r2-t3.1-t1.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-r3-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-r4-t1.1-t3.1", "type": "connected_to", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-r5-t1.1-t3.2", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s3-r6-t3.1-t3.2", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-r1-t4.1-t6.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-r2-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-r3-t6.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-r4-t6.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-r5-t1.2-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-r6-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-r7-t3.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s4-r8-t4.1-t3.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r1-t3.1-t2.1", "type": "surrounds", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r2-t4.1-t6.1", "type": "precedes", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r3-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r4-t7.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r5-t2.1-t3.1", "type": "developmental_form_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r6-t4.1-t1.2", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r7-t1.1-t6.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r8-t2.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r9-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r10-t7.1-t6.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s5-t7", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r11-t1.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s5-r12-t3.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r1-t2.2-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r2-t2.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r3-t5.2-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r4-t2.1-t1.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r5-t2.1-t5.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r6-t5.2-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r7-t1.1-t4.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r9-t5.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t5", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r10-t3.1-t5.1", "type": "precedes", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r11-t3.1-t2.2", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r12-t1.1-t2.2", "type": "measures", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r13-t2.1-t3.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s7-r14-t3.1-t4.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s8-r1-t1.1-t2.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t1", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570375.ger.abstr-s8-r2-t3.1-t2.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.80570375.ger.abstr-s8-t3", "arg2_id": "ZfuerRheumatologie.80570375.ger.abstr-s10-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570392.ger.abstr-passage-0", "type": "abstract", "text": [ "Aufgabenstellung : Die entzuendliche Aktivitaet der rheumatoiden Arthritis ( RA ) spiegelt sich nur unzureichend in Laborparametern wider . Proteolytische Enzyme , die an der Gelenkzerstoerung beteiligt sind , koennten geeignete Marker der Krankheitsaktivitaet darstellen . Die vorliegende Studie vergleicht die Wertigkeit von zwei Proteasenfamilien , der Matrix-Metalloproteinasen und der Cysteinproteinasen Cathepsin B , H and L und ihrer jeweiligen Inhibitoren fuer die Beurteilung der klinischen Aktivitaet der RA ." ], "offsets": [ [ 0, 519 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570392.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Arthritis" ], "offsets": [ [ 65, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003864" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "rheumatoiden Arthritis" ], "offsets": [ [ 52, 74 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003873" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Enzyme" ], "offsets": [ [ 155, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014442" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Gelenkzerstoerung" ], "offsets": [ [ 175, 192 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022417" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Marker" ], "offsets": [ [ 229, 235 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Proteolytische Enzyme" ], "offsets": [ [ 140, 161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030940" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Proteasenfamilien" ], "offsets": [ [ 332, 349 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030946" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Proteasenfamilien" ], "offsets": [ [ 332, 349 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015576" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Matrix-Metalloproteinasen" ], "offsets": [ [ 356, 381 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0623362" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "type": "umlsterm", "text": [ "Beurteilung" ], "offsets": [ [ 473, 484 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0022423" } ] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t5", "type": "umlsterm", "text": [ "Cathepsin B" ], "offsets": [ [ 409, 420 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0699919" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-r1-t3.2-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-r2-t4.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-r3-t4.1-t3.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-r4-t3.2-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-r5-t1.1-t3.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s2-r6-t1.1-t4.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r1-t4.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r2-t3.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r3-t4.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r4-t5.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r5-t4.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r6-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r7-t1.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r8-t5.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r9-t4.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r10-t5.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t5", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r11-t3.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t3", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r12-t1.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570392.ger.abstr-s3-r13-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570392.ger.abstr-s3-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570399.ger.abstr-passage-0", "type": "abstract", "text": [ "Die schwangerschaftsinduzierte Algodystrophie ist eine seltene Erkrankung , die zudem kaum diagnostiziert wird , da die Beschwerden haeufig als statische oder ligamentaere , durch die Schwangerschaft bedingte Probleme verkannt werden . Eine rechtzeitige Diagnosestellung ist jedoch ebenso wie die Einleitung einer adaequaten Therapie notwendig , um Komplikationen zu verhindern sowie Schmerzen zu bekaempfen . In dieser Arbeit wird ueber den aktuellen Kenntnisstand zu dieser Erkrankung berichtet . Darueber hinaus werden anhand von zwei Erkrankungsfaellen der klinische Verlauf und die phasenspezifische Diagnostik und Therapie dargestellt . Im Ergebnis unserer klinischen Beobachtungen stellen wir die bisher uebliche Trennung von schwangerschaftsinduzierter Algodystrophie und postpartaler Osteoporose in Frage und diskutieren die Vermutung , dass es sich hierbei um zwei Krankheitsbilder handelt , die sich ueber die Stoerung des Knochen- und Kalziummetabolismus gegenseitig beeinflussen ." ], "offsets": [ [ 0, 993 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570399.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Algodystrophie" ], "offsets": [ [ 31, 45 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205930" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Schwangerschaft" ], "offsets": [ [ 184, 199 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0032961" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Diagnosestellung" ], "offsets": [ [ 254, 270 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 325, 333 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Komplikationen" ], "offsets": [ [ 349, 363 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009566" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 384, 393 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Arbeit" ], "offsets": [ [ 420, 426 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043227" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Diagnostik" ], "offsets": [ [ 605, 615 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011900" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 620, 628 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Beobachtungen" ], "offsets": [ [ 674, 687 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Algodystrophie" ], "offsets": [ [ 761, 775 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0205930" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Osteoporose" ], "offsets": [ [ 793, 804 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029456" } ] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Knochen-" ], "offsets": [ [ 934, 942 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-r1-t3.1-t2.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-r2-t1.1-t2.2", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-r3-t2.2-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-r4-t1.1-t2.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-r5-t2.2-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-r6-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s2-r7-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s4-r1-t1.1-t2.1", "type": "precedes", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s5-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s5-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s5-r3-t4.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570399.ger.abstr-s5-r4-t2.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.80570399.ger.abstr-s5-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570410.ger.abstr-passage-0", "type": "abstract", "text": [ "In den letzten Jahren wurde in Deutschland eine Budgetierung der Ausgaben im Gesundheitswesen unter staatsoekonomischen Aspekten durchgefuehrt . Seit einem Jahr sind Ansaetze zu einer differenzierten Steuerung der Ausgaben bei chronischen Krankheiten erkennbar . Im Mittelpunkt dieser Ueberlegungen steht Qualitaetssicherung , die vorrangig prozessual ( Vernetzung ) und fiskalisch ( Einsparung ) definiert ist . Vertragsrechtliche und betriebswirtschaftliche Konsequenzen fuer den Unternehmer \" Fachrheumatologe in eigener Praxis \" werden aufgezeigt ." ], "offsets": [ [ 0, 552 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570410.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Deutschland" ], "offsets": [ [ 31, 42 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "ZfuerRheumatologie.80570410.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Gesundheitswesen" ], "offsets": [ [ 77, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0525053" } ] }, { "id": "ZfuerRheumatologie.80570410.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Krankheiten" ], "offsets": [ [ 239, 250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.80570410.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "chronischen Krankheiten" ], "offsets": [ [ 227, 250 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008679" } ] }, { "id": "ZfuerRheumatologie.80570410.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Praxis" ], "offsets": [ [ 524, 530 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033174" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570410.ger.abstr-s1-r1-t1.1-t2.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.80570410.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.80570410.ger.abstr-s2-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570413.ger.abstr-passage-0", "type": "abstract", "text": [ "Qualitaetsmanagement in der Rheumatologie dient dem Ziel , das Behandlungsergebnis ( Outcome ) zu optimieren . Dies geschieht durch prospektive Laengsschnittbeobachtung des Patienten mit moeglichst standardisierter Dokumentation des klinischen , radiologischen , und funktionellen Zustandes ( z.B. Disease Activity Score , Funktionsfragebogen Hannover , Roentgenscore Short , Form 36 ) und Anpassung der Behandlung auf der Grundlage der gemessenen Daten . Um diese Aufgaben erfuellen zu koennen , benoetigt das Fachkrankenhaus eine bestimmte Struktur . Dazu zaehlt u.a. die Moeglichkeit der direkten Einweisung durch den Hausarzt , Ambulanz zwecks Langzeitbeobachtung , ein multidisziplinaeres therapeutisches Team mit Internisten/Rheumatologen , Orthopaeden/Rheumachirurgen mit Weiterbildungsmoeglichkeit in beiden Disziplinen auf dem Boden eines entsprechend grossen Diagnose- und Operationsspektrums , Physio- und Ergotherapie , spezialisierte Pflege , psychologische und soziale Betreuung , Labor , Roentgenabteilung , Kooperation mit weiteren fachaerztlichen Disziplinen , Kooperation mit den niedergelassenen Aerzten und Patientenselbsthilfeorganisationen etc. Faktoren , die die Prozessqualitaet als Voraussetzung fuer gute Ergebnisqualitaet beeinflussen , sind u.a. Auswahl , Schulung und Motivation der Mitarbeiter , einheitliche Befundung und Dokumentation , woechentliche Chefvisiten , taegliche Fall- und Roentgenbesprechungen , interdisziplinaere Fallvorstellungen und regelmaessige gegenseitige Konsiliartaetigkeit der beiden Abteilungen , institutionalisierte Teambesprechungen , Koordination der Arbeitsablaeufe aller Abteilungen zur Vermeidung von Leerlaeufen , Fortbildungsveranstaltungen fuer Aerzte sowie auch fuer Physio- und Ergotherapie , Pflegedienst und Labor , Kongressteilnahme , eigene wissenschaftliche Taetigkeit etc. Die Prozessqualitaet sollte dabei durch interdisziplinaere und abteilungsuebergreifende Kommunikation regelmaessig dokumentiert und optimiert werden . Die Ergebnisqualitaet ist durch regelmaessige ambulante Ueberpruefung von Therapie und Befund unter Einschluss des Patientenurteils mit Anpassung der Behandlung an die erhobenen Daten zu sichern . Fuer die Zukunft anzustreben ist eine einheitliche Dokumentation aller Patienten durch klinische und niedergelassene Rheumatologen mit zentraler Datensammlung , zeitnahe Rueckmeldung der eigenen und Gruppendaten zum Zweck der Therapieoptimierung und damit auch Anhebung der Qualitaet der rheumatologischen Versorgung in Deutschland ." ], "offsets": [ [ 0, 2529 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570413.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Rheumatologie" ], "offsets": [ [ 28, 41 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035452" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Behandlungsergebnis" ], "offsets": [ [ 63, 82 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0085415" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Laengsschnittbeobachtung" ], "offsets": [ [ 144, 168 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 173, 182 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Dokumentation" ], "offsets": [ [ 215, 228 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012972" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "radiologischen" ], "offsets": [ [ 246, 260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034546" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Funktionsfragebogen" ], "offsets": [ [ 323, 342 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034394" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 404, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Fachkrankenhaus" ], "offsets": [ [ 511, 526 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019994" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Hausarzt" ], "offsets": [ [ 621, 629 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031835" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Langzeitbeobachtung" ], "offsets": [ [ 648, 667 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Langzeitbeobachtung" ], "offsets": [ [ 648, 667 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0302523" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Boden" ], "offsets": [ [ 836, 841 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037592" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t5", "type": "umlsterm", "text": [ "Diagnose-" ], "offsets": [ [ 869, 878 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t6", "type": "umlsterm", "text": [ "Pflege" ], "offsets": [ [ 947, 953 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028682" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t7", "type": "umlsterm", "text": [ "Aerzten" ], "offsets": [ [ 1115, 1122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "type": "umlsterm", "text": [ "Patientenselbsthilfeorganisationen" ], "offsets": [ [ 1127, 1161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t9", "type": "umlsterm", "text": [ "Patientenselbsthilfeorganisationen" ], "offsets": [ [ 1127, 1161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036592" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t10", "type": "umlsterm", "text": [ "Patientenselbsthilfeorganisationen" ], "offsets": [ [ 1127, 1161 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0029246" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "type": "umlsterm", "text": [ "Motivation" ], "offsets": [ [ 1297, 1307 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026605" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t12", "type": "umlsterm", "text": [ "Dokumentation" ], "offsets": [ [ 1353, 1366 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012972" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t13", "type": "umlsterm", "text": [ "Aerzte" ], "offsets": [ [ 1712, 1718 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t14", "type": "umlsterm", "text": [ "Pflegedienst" ], "offsets": [ [ 1762, 1774 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028682" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t15", "type": "umlsterm", "text": [ "Kongressteilnahme" ], "offsets": [ [ 1787, 1804 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009753" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "type": "umlsterm", "text": [ "Kommunikation" ], "offsets": [ [ 1936, 1949 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009452" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t17", "type": "umlsterm", "text": [ "niedergelassenen Aerzten" ], "offsets": [ [ 1098, 1122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033131" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 2073, 2081 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Patientenurteils" ], "offsets": [ [ 2114, 2130 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 2149, 2159 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Dokumentation" ], "offsets": [ [ 2247, 2260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012972" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 2267, 2276 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Datensammlung" ], "offsets": [ [ 2341, 2354 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0010995" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "zeitnahe" ], "offsets": [ [ 2357, 2365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "type": "umlsterm", "text": [ "Therapieoptimierung" ], "offsets": [ [ 2422, 2441 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t6", "type": "umlsterm", "text": [ "Deutschland" ], "offsets": [ [ 2516, 2527 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570413.ger.abstr-s1-r1-t2.1-t1.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-r1-t6.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t6", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-r2-t2.1-t5.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-r3-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-r4-t2.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-r5-t2.1-t6.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s2-r6-t2.1-t4.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r1-t16.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r2-t5.1-t11.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r3-t10.1-t14.1", "type": "carries_out", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t10", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t14", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r4-t14.1-t16.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t14", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r5-t5.1-t16.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r6-t10.1-t12.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t10", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r7-t8.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r8-t3.1-t16.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r9-t15.1-t16.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t15", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r10-t14.1-t11.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t14", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r11-t3.1-t11.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r12-t9.1-t11.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r13-t10.1-t16.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t10", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r14-t8.1-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r15-t5.1-t16.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r16-t11.1-t16.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r17-t10.1-t5.1", "type": "carries_out", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t10", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r18-t2.1-t16.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r19-t8.1-t16.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r20-t8.1-t17.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t17", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r21-t8.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r22-t12.1-t16.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t12", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r23-t4.1-t16.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t4", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r24-t10.1-t3.1", "type": "carries_out", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t10", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r25-t16.1-t17.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t17", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r26-t8.1-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r27-t8.1-t13.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r28-t8.1-t14.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t14", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r29-t9.1-t16.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t9", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r30-t16.1-t13.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t13", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r31-t2.1-t11.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r32-t8.1-t9.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r33-t16.1-t8.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r34-t16.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r35-t8.1-t16.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r36-t15.1-t11.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t15", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r37-t11.1-t16.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r38-t8.1-t12.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t8", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t12", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r39-t10.1-t16.1", "type": "carries_out", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t10", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r40-t11.1-t2.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r41-t16.1-t11.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t16", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r42-t5.1-t11.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r43-t10.1-t9.1", "type": "carries_out", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t10", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r44-t11.1-t15.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t11", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s4-t15", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s4-r45-t3.1-t2.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s5-r1-t1.2-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s5-r2-t1.1-t1.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s5-r3-t3.1-t1.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s5-r4-t1.2-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-r1-t2.1-t3.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-r2-t5.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-r3-t3.1-t4.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-r4-t2.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570413.ger.abstr-s6-r5-t2.1-t5.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.80570413.ger.abstr-s6-t5", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570420.ger.abstr-passage-0", "type": "abstract", "text": [ "Das Qualitaetssicherungsprogramm des VDR und die Veroeffentlichungen zur Qualitaetssicherung der DGRh geben den Rahmen fuer die externen Qualitaetssicherungsmassnahmen vor . Durch Einfuehrung eines umfassenden Qualitaetsmanagements in einer Rehabilitationsklinik konnte die Qualitaet messbar gesteigert werden . Die Verbesserungen wurden durch Umsetzung zielgerichteter Massnahmen und Veraenderung von Klinikstrukturen erreicht . Bisher standen Massnahmen bezogen auf Patientenbeduerfnisse und die Aufarbeitung von internen Behandlungsablaeufen im Vordergrund . Zur Erhoehung der Mitarbeiterzufriedenheit und -qualifikation wurden rehabilitationsspezifische Fortbildungsreihen durchgefuehrt . Neue zukunftsweisende Perspektiven konnten gemeinsam mit anderen Partnern entwickelt werden ." ], "offsets": [ [ 0, 786 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570420.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Patientenbeduerfnisse" ], "offsets": [ [ 468, 489 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] } ]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.80570424.ger.abstr-passage-0", "type": "abstract", "text": [ "Durch den Aufbau von Rheumazentren in Deutschland konnte in den letzten Jahren eine Vernetzung von ambulantem und stationaerem Bereich mit den darin taetigen niedergelassenen Hausaerzten , internistischen und orthopaedischen Fachrheumatologen , Krankengymnasten , Ergotherapeuten und Psychologen sowie den Akut- und Rehabilitationskliniken erreicht werden . Diese Strukturverbesserung in der Versorgung chronisch Rheumakranker muss in Zukunft auch eine Prozess- und Ergebnisoptimierung nach sich ziehen . Rheumatologische Leitstellen koennen auf Dauer dazu beitragen , die Kooperation zwischen allen an der Versorgung Rheumakranker beteiligten Aerzten , Therapeuten und Kliniken weiter zu verbessern und eine kontinuierliche und langfristige Behandlung und Betreuung chronisch Rheumakranker im Sinne eines komprehensiven rheumatologischen Qualitaetsmanagements quantitativ und qualitativ sicherstellen ." ], "offsets": [ [ 0, 903 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570424.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Deutschland" ], "offsets": [ [ 38, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "ZfuerRheumatologie.80570424.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Hausaerzten" ], "offsets": [ [ 175, 186 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031835" } ] }, { "id": "ZfuerRheumatologie.80570424.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Krankengymnasten" ], "offsets": [ [ 245, 261 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570424.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Aerzten" ], "offsets": [ [ 644, 651 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.80570424.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 742, 752 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570424.ger.abstr-s1-r1-t2.1-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570424.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.80570424.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570424.ger.abstr-s1-r2-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570424.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.80570424.ger.abstr-s3-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570424.ger.abstr-s3-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570424.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570424.ger.abstr-s3-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570434.ger.abstr-passage-0", "type": "abstract", "text": [ "Selfmanagement laesst sich beschreiben als ein Verhalten des Patienten im Umgang mit einer chronischen Erkrankung . Dieses Verhalten umfasst die Selbstbeobachtung oder Messung , die Entscheidung ueber notwendige Massnahmen , Selbstbehandlung und schliesslich Dokumentation . Selfmanagement laesst sich foerdern und traegt zu einer optimierten Behandlung der Erkrankung bei ." ], "offsets": [ [ 0, 374 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570434.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Verhalten" ], "offsets": [ [ 47, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "ZfuerRheumatologie.80570434.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 61, 70 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570434.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Verhalten" ], "offsets": [ [ 123, 132 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "ZfuerRheumatologie.80570434.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Selbstbehandlung" ], "offsets": [ [ 225, 241 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.80570434.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Dokumentation" ], "offsets": [ [ 259, 272 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012972" } ] }, { "id": "ZfuerRheumatologie.80570434.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 343, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570434.ger.abstr-s1-r1-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570434.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.80570434.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570434.ger.abstr-s1-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570434.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.80570434.ger.abstr-s2-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570437.ger.abstr-passage-0", "type": "abstract", "text": [ "Ein nach Prinzipien der Erwachsenenbildung ( Andragogik ) von der Projektgruppe \" Fortbildung und Qualitaetssicherung \" der AG Regionaler Kooperativer Rheumazentren entwickeltes Fortbildungskonzept fuer niedergelassene Hausaerzte ( 3 ) wurde im Rahmen eines BMG-gefoerderten Projektes ( FB 2-43346-8/63 ) als Instrument der Qualitaetssicherung in der Rheumatologie erprobt und evaluiert . Das Fortbildungskonzept ist zum Einsatz in hausaerztlichen Qualitaetszirkeln vorgesehen . Evaluiert wurde das Konzept in jeweils 2 Qualitaetszirkeln der KV Hessen und der KV Niedersachsen . Beteiligt waren insgesamt 39 Hausaerzte und 3 Rheumatologen in der Funktion des Experten \" . \" Behandelt wurde in allen evaluierten Qualitaetszirkeln das Thema \" Schulter-Nacken-Schmerz \" unter Verwendung vorbereiteter didaktischer Materialien . Als Evaluationsinstrumente dienten Frageboegen und die Dokumentation von Patienten mit Schulter-Nacken-Schmerz durch die teilnehmenden Aerzte . Die Evaluation wurde wissenschaftlich begleitet durch das Wissenschaftliche Institut der Aerzte Deutschlands ( WIAD ) . Es wurden insgesamt 2151 Patienten mit Schulter-Nacken-Schmerz dokumentiert ; davon 1193 vor Absolvierung des Qualitaetszirkels und 957 nach erfolgter Fortbildung . Dokumentiert wurde die klinische Diagnose sowie das diagnostische und therapeutische Vorgehen . Vor und nach Intervention wurden 10 MC-Wissensfragen zum Thema vorgelegt . Am Ende des Qualitaetszirkels wurde ebenfalls mittels Fragebogen die Akzeptanz des Fortbildungskonzeptes bei den Teilnehmern ermittelt . Es wurde mit einem Akzeptanzindex von durchschnittlich 9,6 Punkten von maximal 7,0 moeglichen - und unguenstigstenfalls 31,0 Punkten - eine hohe Akzeptanz des Fortbildungskonzeptes bei den Teilnehmern ermittelt . Die bestehende Wissensluecke wurde gleichmaessig ueber alle 4 Qualitaetszirkel verteilt um durchschnittlich 30% verkleinert . Im diagnostischen und therapeutischen Verhalten der Aerzte konnte eine bessere Spezifikation der Einzeldiagnosen zum Thema Schulter-Nacken-Schmerz , eine signifikante Reduktion nicht indizierter , z.T. kostenintensiver diagnostischer Massnahmen ( z.B. CT ) sowie eine Abnahme kontraindizierter therapeutischer Massnahmen ( z.B. Massagen Fango , Salben , Gele ) , zugunsten sinnvoller Massnahmen ( z.B. Krankengymnastik , lokale und systemische Kortikosteroid-Therapie ) registriert werden . Das Ergebnis der Evaluation zeigt , dass andragogisch konzipiertes interaktives Lernen in kleinen Gruppen ( Qualitaetszirkel ) zur Verbesserung der Versorgungsqualitaet bei Patienten mit Erkrankungen aus dem rheumatischen Formenkreis beitragen kann . Das innovative Fortbil-dungskonzept wird von den Aerzten akzeptiert und kann als Alternative und Ergaenzung zur formalen Frontalfortbildung empfohlen werden ." ], "offsets": [ [ 0, 2801 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570437.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Fortbildung" ], "offsets": [ [ 82, 93 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013626" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Hausaerzte" ], "offsets": [ [ 219, 229 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031835" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Instrument" ], "offsets": [ [ 309, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Rheumatologie" ], "offsets": [ [ 351, 364 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035452" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Hausaerzte" ], "offsets": [ [ 608, 618 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031835" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Schulter-Nacken-Schmerz" ], "offsets": [ [ 741, 764 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037004" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Schulter-Nacken-Schmerz" ], "offsets": [ [ 741, 764 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Verwendung" ], "offsets": [ [ 773, 783 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042153" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Dokumentation" ], "offsets": [ [ 880, 893 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012972" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 898, 907 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Schulter-Nacken-Schmerz" ], "offsets": [ [ 912, 935 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037004" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Schulter-Nacken-Schmerz" ], "offsets": [ [ 912, 935 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-t5", "type": "umlsterm", "text": [ "Aerzte" ], "offsets": [ [ 960, 966 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Aerzte" ], "offsets": [ [ 1058, 1064 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Deutschlands" ], "offsets": [ [ 1065, 1077 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017480" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Wissenschaftliche Institut" ], "offsets": [ [ 1027, 1053 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021622" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 1114, 1123 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Schulter-Nacken-Schmerz" ], "offsets": [ [ 1128, 1151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037004" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s8-t3", "type": "umlsterm", "text": [ "Schulter-Nacken-Schmerz" ], "offsets": [ [ 1128, 1151 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s8-t4", "type": "umlsterm", "text": [ "Fortbildung" ], "offsets": [ [ 1240, 1251 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013626" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Diagnose" ], "offsets": [ [ 1287, 1295 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Fragebogen" ], "offsets": [ [ 1479, 1489 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034394" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s13-t1", "type": "umlsterm", "text": [ "Qualitaetszirkel" ], "offsets": [ [ 1837, 1853 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086888" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t1", "type": "umlsterm", "text": [ "Verhalten" ], "offsets": [ [ 1939, 1948 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004927" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t2", "type": "umlsterm", "text": [ "Aerzte" ], "offsets": [ [ 1953, 1959 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t3", "type": "umlsterm", "text": [ "Einzeldiagnosen" ], "offsets": [ [ 1998, 2013 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t4", "type": "umlsterm", "text": [ "Schulter-Nacken-Schmerz" ], "offsets": [ [ 2024, 2047 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037004" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t5", "type": "umlsterm", "text": [ "Schulter-Nacken-Schmerz" ], "offsets": [ [ 2024, 2047 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t6", "type": "umlsterm", "text": [ "Massagen" ], "offsets": [ [ 2229, 2237 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024875" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t7", "type": "umlsterm", "text": [ "Gele" ], "offsets": [ [ 2255, 2259 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017243" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s15-t1", "type": "umlsterm", "text": [ "Lernen" ], "offsets": [ [ 2472, 2478 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023185" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s15-t2", "type": "umlsterm", "text": [ "Qualitaetszirkel" ], "offsets": [ [ 2500, 2516 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086888" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s15-t3", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 2565, 2574 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "type": "umlsterm", "text": [ "Aerzten" ], "offsets": [ [ 2692, 2699 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031831" } ] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "type": "umlsterm", "text": [ "Frontalfortbildung" ], "offsets": [ [ 2764, 2782 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013626" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570437.ger.abstr-s1-r1-t1.1-t3.1", "type": "method_of", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s15-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s1-r2-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s1-r3-t2.1-t3.1", "type": "issue_in", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s15-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s5-r1-t3.1-t1.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s15-t3", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-r1-t2.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-r2-t2.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-r3-t5.1-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t5", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s6-r4-t5.1-t2.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t5", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s7-r1-t1.1-t3.1", "type": "manages", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s15-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s8-r1-t1.1-t4.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-r1-t2.1-t1.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-r2-t2.1-t6.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-r3-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-r4-t6.1-t5.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t6", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s14-r5-t3.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s15-t3", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s14-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.80570437.ger.abstr-s16-r1-t1.1-t2.1", "type": "performs", "arg1_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t1", "arg2_id": "ZfuerRheumatologie.80570437.ger.abstr-s16-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.80570446.ger.abstr-passage-0", "type": "abstract", "text": [ "Erst in den letzten Jahren wird zunehmend ein Instrumentarium dafuer erarbeitet , die traditionell subjektiv und empirisch determinierten Therapieentscheidungen zum Einsatz von Basistherapeutika mehr auf den Boden objektiver Qualitaetskriterien zu stellen . Ein optimiertes Qualitaetsmanagement fuer diese Therapie sollte Faktoren wie fruehestmoegliche Diagnosestellung ( als Voraussetzung fuer die Einleitung einer Basistherapie ) , zuverlaessige Einschaetzung der individuellen Krankheitsprognose ( als wichtige Entscheidungshilfe fuer die Wahl der geeigneten Substanz ) , rasche Festlegung und Einleitung der ausgewaehlten Therapie und eine optimale Langzeit-Durchfuehrung dieser Therapie ( mit zuverlaessiger Ueberwachung von Effektivitaet , Vertraeglichkeit und Compliance ) beinhalten . Die hierfuer noetigen Werkzeuge stehen bisher nur teilweise zur Verfuegung , so z.B. validierte Diagnosekriterien und Ueberwachungsrichtlinien . Neben den partiell noch fehlenden geeigneten Instrumenten steht einem optimalen Qualitaetsmanagement aber gegenwaertig - bedingt durch einen Mangel an Spezialisten bzw. deren zu zoegerliche Miteinbeziehung - auch eine mangelhafte rheumatologische Fachbetreuung vieler Rheumatiker entgegen . Dennoch ist aufgrund der neueren Entwicklungen zu hoffen , dass die Luecke zwischen Bedarf und Moeglichkeiten des Qualitaetsmanagements immer geringer wird ." ], "offsets": [ [ 0, 1386 ] ] } ]

[ { "id": "ZfuerRheumatologie.80570446.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Therapieentscheidungen" ], "offsets": [ [ 138, 160 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Boden" ], "offsets": [ [ 208, 213 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037592" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 306, 314 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Diagnosestellung" ], "offsets": [ [ 353, 369 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Basistherapie" ], "offsets": [ [ 416, 429 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 626, 634 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Langzeit-Durchfuehrung" ], "offsets": [ [ 653, 675 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0040223" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t6", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 683, 691 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t7", "type": "umlsterm", "text": [ "Compliance" ], "offsets": [ [ 767, 777 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009563" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Diagnosekriterien" ], "offsets": [ [ 889, 906 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Instrumenten" ], "offsets": [ [ 983, 995 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0021632" } ] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Mangel" ], "offsets": [ [ 1079, 1085 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011155" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-r2-t6.2-t1.2", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-r3-t6.2-t1.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570446.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.80570446.ger.abstr-s2-r4-t6.2-t3.2", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t6", "arg2_id": "ZfuerRheumatologie.80570446.ger.abstr-s2-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s001.ger.abstr-passage-0", "type": "abstract", "text": [ "Die Intergration nozizeptiver Signale umfasst periphere spinale und supraspinale Strukturen , des Nervensystems . Unterschiedliche exzitatorische und inhibitorische Neurotransmitter und -modulatoren nehmen an der Schmerzverarbeitung und -modulation teil . Chronische Schmerzzustaende spiegeln sich in neuroplastischen Veraenderungen auf verschiedenen Ebenen der Integration nozizeptiver Information wider . Die Vielzahl dynamischer Veraenderungen in den pharmakologisch unterschiedlichen Systemen bieten neue pharmakotherapeutische Ansatzpunkte ." ], "offsets": [ [ 0, 546 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s001.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Nervensystems" ], "offsets": [ [ 98, 111 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027763" } ] }, { "id": "ZfuerRheumatologie.8057s001.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Neurotransmitter" ], "offsets": [ [ 165, 181 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027908" } ] }, { "id": "ZfuerRheumatologie.8057s001.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Schmerzverarbeitung" ], "offsets": [ [ 213, 232 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s001.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Schmerzzustaende" ], "offsets": [ [ 267, 283 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] } ]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s005.ger.abstr-passage-0", "type": "abstract", "text": [ "Depression und Fibromyalgie ( FM ) weisen gemeinsame Symptome auf , welche auf eine enge Beziehung zwischen beiden Erkrankungen hinweisen . FM-Patienten zeigen haeufig Symptome der Major Depression . Genetisch-epidemiologische Studien belegen , dass Vererbung eine wesentliche Rolle spielt . Molekulargenetische Studien werden gegenwaertig durchgefuehrt . Das Promotergen fuer den Serotonintransporter ist u.U. assoziiert mit neurotischer Anxiety und FM . Biochemische Studien weisen darauf hin , dass bei beiden Erkrankungen das Serotonin- und Norepinephrinsystem gestoert sein kann . Diese Theorie wird unterstuetzt durch die Response auf die Behandlung mit Antidepressiva ." ], "offsets": [ [ 0, 676 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Depression" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 15, 27 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "FM-Patienten" ], "offsets": [ [ 140, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Depression" ], "offsets": [ [ 187, 197 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0011570" } ] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 277, 282 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Promotergen" ], "offsets": [ [ 360, 371 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 645, 655 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Antidepressiva" ], "offsets": [ [ 660, 674 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0003289" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s1-r1-t2.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s1-r2-t1.1-t2.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s2-r1-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-r1-t1.1-t2.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t1", "arg2_id": "ZfuerRheumatologie.8057s005.ger.abstr-s7-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s008.ger.abstr-passage-0", "type": "abstract", "text": [ "C-Faser Nozizeptoren haben neben ihrer afferenten auch lokale efferente Funktionen , wie Vasodilatation , Plasmaextravasation und die Modulation neuronaler Aktivitaet , die durch Freisetzung der Neuropeptide Substanz P , Neurokinin A und Calcitonin Gene-Related Peptide ( CGRP ) an der peripheren Endigung ausgeloest werden . In der Haut der Saeugetiere ( einschliesslich Mensch ) ist CGRP der wichtigste Mediator der Flarereaktion . Die Vasodilatation wird beim Schwein durch Aktivierung von spezifischen Hitzenozizeptoren induziert . Bei der Taube wird die antidrome Vasodilatation durch intrinsisch freigesetztes Galanin gehemmt . Plasmaextravasation kann beim Schwein in Hautblasen und mit der Mikrodialyse durch Histaminsuperfusion , nicht aber durch elektrische Stimulation und Capsaicin , ausgeloest werden . Die neurogene Komponente der Histaminantwort ( 64% ) wird durch NK2-Rezeptoren vermittelt und kann durch CGRP moduliert werden . Die genannten Neuropeptide koennen zur Sensibilisierung und unter bestimmten Bedingungen zur Stimulation von Nozizeptoren fuehren . Die erhoehte Sensitivitaet der Flarereaktion bei Fibromyalgiepatienten deutet auf eine veraenderte Funktion der C-Faser Nozizeptoren hin ." ], "offsets": [ [ 0, 1215 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Nozizeptoren" ], "offsets": [ [ 8, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028246" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "afferenten" ], "offsets": [ [ 39, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026447" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "afferenten" ], "offsets": [ [ 39, 49 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030854" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Vasodilatation" ], "offsets": [ [ 89, 103 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042401" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Neuropeptide" ], "offsets": [ [ 195, 207 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027895" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Calcitonin" ], "offsets": [ [ 238, 248 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006668" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t7", "type": "umlsterm", "text": [ "Peptide" ], "offsets": [ [ 262, 269 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030956" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "type": "umlsterm", "text": [ "Substanz P" ], "offsets": [ [ 208, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038585" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "type": "umlsterm", "text": [ "Neurokinin A" ], "offsets": [ [ 221, 233 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038581" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Haut" ], "offsets": [ [ 333, 337 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Saeugetiere" ], "offsets": [ [ 342, 353 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0024660" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Mensch" ], "offsets": [ [ 372, 378 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020114" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Vasodilatation" ], "offsets": [ [ 438, 452 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042401" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Schwein" ], "offsets": [ [ 463, 470 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039005" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Taube" ], "offsets": [ [ 544, 549 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031905" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Vasodilatation" ], "offsets": [ [ 569, 583 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042401" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Galanin" ], "offsets": [ [ 616, 623 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0060993" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Schwein" ], "offsets": [ [ 664, 671 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039005" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Hautblasen" ], "offsets": [ [ 675, 685 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Hautblasen" ], "offsets": [ [ 675, 685 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005758" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Mikrodialyse" ], "offsets": [ [ 698, 710 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0206056" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "Capsaicin" ], "offsets": [ [ 784, 793 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006931" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "type": "umlsterm", "text": [ "elektrische Stimulation" ], "offsets": [ [ 756, 779 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013786" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Histaminantwort" ], "offsets": [ [ 845, 860 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0019588" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Neuropeptide" ], "offsets": [ [ 959, 971 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027895" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Nozizeptoren" ], "offsets": [ [ 1054, 1066 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028246" } ] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Nozizeptoren" ], "offsets": [ [ 1197, 1209 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0028246" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r1-t1.1-t6.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r2-t8.1-t9.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r3-t5.1-t8.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r4-t8.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r5-t5.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r6-t1.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r7-t6.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r8-t9.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r9-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r10-t5.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r11-t8.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r12-t4.1-t9.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r13-t6.1-t8.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r14-t8.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r15-t9.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r16-t9.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r17-t2.1-t4.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r18-t9.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r19-t4.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r20-t4.1-t8.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r21-t1.1-t2.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r22-t6.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r23-t5.1-t9.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r24-t1.1-t9.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r25-t8.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r26-t5.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r27-t8.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r28-t4.1-t6.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r29-t6.1-t9.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r30-t1.1-t8.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r31-t9.1-t8.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t8", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r32-t6.1-t7.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r33-t9.1-t6.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t9", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r34-t4.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r35-t1.1-t7.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r36-t6.1-t5.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s1-r37-t5.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-r1-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-r2-t1.1-t3.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-r3-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-r4-t1.1-t3.1", "type": "property_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-r5-t1.1-t2.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s2-r6-t1.1-t2.1", "type": "property_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s3-r1-t1.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s4-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s4-r2-t3.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s4-r3-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r1-t5.1-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r2-t6.1-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r3-t4.1-t5.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r4-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r5-t6.1-t5.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r6-t2.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r7-t3.1-t2.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r8-t3.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r9-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r10-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r11-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r12-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r13-t3.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r14-t4.1-t2.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r15-t2.1-t1.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r16-t2.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r17-t5.1-t3.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r18-t5.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t5", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r19-t2.1-t1.1", "type": "property_of", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r20-t6.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-r21-t6.1-t4.1", "type": "isa", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t6", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-r1-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-r2-t1.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s008.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s008.ger.abstr-s7-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s014.ger.abstr-passage-0", "type": "abstract", "text": [ "Schmerz ist das komplizierte Resultat verschiedener neuronaler Aktivitaeten unseres Gehirns und nicht nur ein einfaches Ergebnis der Taetigkeit des peripheren nozizeptiven Systems . Schmerz resultiert aus dem Zusammenspiel verschiedener Module im Gehirn , die sich in verschiedenen Hirnarealen befinden und durch Erwartung , Lernen , Erfahrung und aehnliches modifiziert werden . Elektrophysiologische Begleiterscheinungen , die mit der Schmerzverarbeitung assoziiert sind , erlauben dabei eine Charakterisierung der ablaufenden Informationsverarbeitungsprozesse . Neben der grundlagentheoretischen Bedeutung spielt hier die Evaluation verschiedener Therapieansaetze eine herausragende Rolle . Zusaetzlich koennen mittels der Registrierung hirnelektrischer Prozesse Vorgaenge der funktionellen Plastizitaet im Zusammenhang mit der Schmerzverarbeitung untersucht werden . Neue quellenanalytische Ansaetze lassen dabei einen deutlichen Erkenntnisgewinn ueber die Rolle einzelner Hirnstrukturen bei der Verarbeitung und Behandlung von Schmerzen erwarten ." ], "offsets": [ [ 0, 1052 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Schmerz" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Gehirns" ], "offsets": [ [ 84, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Schmerz" ], "offsets": [ [ 182, 189 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Gehirn" ], "offsets": [ [ 247, 253 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Hirnarealen" ], "offsets": [ [ 282, 293 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Lernen" ], "offsets": [ [ 325, 331 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023185" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Schmerzverarbeitung" ], "offsets": [ [ 437, 456 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Therapieansaetze" ], "offsets": [ [ 650, 666 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 686, 691 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "hirnelektrischer" ], "offsets": [ [ 740, 756 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Schmerzverarbeitung" ], "offsets": [ [ 831, 850 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 961, 966 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Hirnstrukturen" ], "offsets": [ [ 977, 991 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 1017, 1027 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 1032, 1041 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s2-r1-t3.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s2-r2-t2.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s2-r3-t1.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t1", "arg2_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-r1-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-r2-t3.1-t4.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t3", "arg2_id": "ZfuerRheumatologie.8057s014.ger.abstr-s6-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s019.ger.abstr-passage-0", "type": "abstract", "text": [ "Die bisherige Forschung zu dem Phaenomen erhoehter Schmerzempfindlichkeit beim Fibromyalgie Syndrom ( FS ) ergab Hinweise sowohl fuer eine erhoehte Schmerzstaerke nach nozizeptiven Reizen ( Hyperalgesie ) als auch fuer eine generelle Verstaerkung sensorischer Wahrnehmungen ( Hypervigilanz ) . Um zwischen diesen beiden Aspekten gestoerter sensorischer Verarbeitung zu unterscheiden , wurden zerebral evozierte Potentiale nach kurzen , schmerzhaften Laser- und auditiven Reizen bei 10 FS-Patienten registriert . Die Ergebnisse wurden mit denen von gleichaltrigen schmerzfreien Kontrollpatienten verglichen . Die Amplituden der Komponenten mittlerer ( N1) und spaeter ( P2) Latenz aus den Laser evozierten Potentialen ( LEP ) waren bei FS-Patienten signifikant groesser als in den Kontrollen . Auch die Laser-Schmerzschwelle , nicht aber die Empfindungsschwelle , waren bei FS-Patienten gegenueber der Kontrollgruppe erniedrigt . Im Gegensatz hierzu unterschieden sich die akustisch evozierten Potentiale zwischen den beiden Studiengruppen nicht . Die vergroesserten N1- und P2-Amplituden der LEP deuten auf eine verstaerkte sensorische und aufmerksamkeitsabhaengige Verarbeitung nozizeptiver Information bei FS hin . Das Fehlen von Unterschieden nach auditiven Reizen stellt das Konzept der Hypervigilanz in Frage . Allerdings wird die Bedeutsamkeit unangenehmer Intensitaeten auditiver Reize , die in dieser Studie nicht verwendet wurden , als Voraussetzung diskutiert , um uebermaessige perzeptive Reaktionen auch durch nicht-nozizeptive Reize bei FS ausloesen zu koennen ." ], "offsets": [ [ 0, 1575 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 14, 23 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 79, 91 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Syndrom" ], "offsets": [ [ 92, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Schmerzstaerke" ], "offsets": [ [ 148, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "Schmerzstaerke" ], "offsets": [ [ 148, 162 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038179" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Hyperalgesie" ], "offsets": [ [ 190, 202 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020429" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "type": "umlsterm", "text": [ "Wahrnehmungen" ], "offsets": [ [ 260, 273 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030971" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Laser-" ], "offsets": [ [ 450, 456 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Kontrollpatienten" ], "offsets": [ [ 577, 594 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Laser" ], "offsets": [ [ 688, 693 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Laser-Schmerzschwelle" ], "offsets": [ [ 802, 823 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0023089" } ] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Laser-Schmerzschwelle" ], "offsets": [ [ 802, 823 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r1-t4.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r2-t7.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r3-t7.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r4-t5.1-t6.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r5-t5.1-t2.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r6-t2.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r7-t1.1-t7.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r8-t2.1-t7.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r9-t7.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r10-t7.1-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r11-t5.1-t7.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r12-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r13-t2.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r14-t3.1-t7.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r15-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r16-t6.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r17-t3.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r18-t5.1-t3.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r19-t5.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r20-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r21-t1.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r22-t4.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r23-t5.1-t4.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r24-t6.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r25-t1.1-t5.1", "type": "measures", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r26-t5.1-t2.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r27-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r28-t5.1-t3.1", "type": "diagnoses", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r29-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r30-t4.1-t7.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t4", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r31-t6.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r32-t6.1-t7.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s019.ger.abstr-s1-r33-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.8057s019.ger.abstr-s5-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s027.ger.abstr-passage-0", "type": "abstract", "text": [ "Patienten mit Fribromyalgie leiden manchmal unter sensiblen und Bewegungsstoerungen , die eine gewisse Aehnlichkeit mit denjenigen bei akinetischen Syndromen aufweisen . Die Akinesie wird durch Funktionsstoerungen in dem kortiko-thalamo-nigro-striatalen System und assoziierte Areale verursacht . Der Grund fuer diese Stoerung liegt bei der Parkinsonschen Krankheit in der verminderten Anzahl dopaminerger Neuronen in der Substantia nigra , pars compacta . Veraenderungen anderer Neurotransmitter , wie GABA oder Serotonin , sowie in den Neurotransmitterreceptoren , sekundaeren Botenstoffen , und sekundaeren Modulierungen nach medikamentoeser Behandlung treten auch auf . Die Aetiologie der nigralen Dysfunktion ist nur in seltenen Faellen bekannt . Toxische Substanzen und Mutationen gewisser Gene sind bekannte Beispiele in der Aetiologie von Bewegungsstoerungen im Allgemeinen . In anderen akinetischen Syndromen , wie die Multisystemaffektion , die kortikobasale ganglionaere Degeneration und die progressive supranukleare Laehmung , wurde ein komplexerer Befall weitere Hirnareale festgestellt . Diese pathologisch-anatomischen Veraenderungen haben typische klinische Folgerungen , die mittels Bildgebung und physiologischen Messungen in vivo untersucht werden koennen . Da die Basalganglien zudem eine Rolle in der Schmerzwahrnehmung spielen , erscheint eine vergleichende Untersuchung ihrer Stoerungen bei Nozizeption ( inklusive Fibromyalgie ) und bei Bewegungsstoerungen vielversprechend , vor allem wenn es dann darum geht neue , rationalere Therapiemodalitaeten , zu finden ." ], "offsets": [ [ 0, 1588 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Bewegungsstoerungen" ], "offsets": [ [ 64, 83 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026650" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Syndromen" ], "offsets": [ [ 148, 157 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Krankheit" ], "offsets": [ [ 356, 365 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Neuronen" ], "offsets": [ [ 406, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027882" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Substantia nigra" ], "offsets": [ [ 422, 438 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038590" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Neurotransmitter" ], "offsets": [ [ 480, 496 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027908" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "GABA" ], "offsets": [ [ 503, 507 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016904" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Serotonin" ], "offsets": [ [ 513, 522 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036751" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-t4", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 645, 655 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Aetiologie" ], "offsets": [ [ 678, 688 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Mutationen" ], "offsets": [ [ 776, 786 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026882" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Gene" ], "offsets": [ [ 796, 800 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0017337" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-t3", "type": "umlsterm", "text": [ "Aetiologie" ], "offsets": [ [ 832, 842 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-t4", "type": "umlsterm", "text": [ "Bewegungsstoerungen" ], "offsets": [ [ 847, 866 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026650" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Syndromen" ], "offsets": [ [ 908, 917 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Laehmung" ], "offsets": [ [ 1029, 1037 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030440" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Hirnareale" ], "offsets": [ [ 1077, 1087 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0006104" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Basalganglien" ], "offsets": [ [ 1285, 1298 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004781" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Rolle" ], "offsets": [ [ 1310, 1315 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035820" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "type": "umlsterm", "text": [ "Schmerzwahrnehmung" ], "offsets": [ [ 1323, 1341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "type": "umlsterm", "text": [ "Schmerzwahrnehmung" ], "offsets": [ [ 1323, 1341 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030971" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 1439, 1451 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "type": "umlsterm", "text": [ "Bewegungsstoerungen" ], "offsets": [ [ 1462, 1481 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026650" } ] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "type": "umlsterm", "text": [ "Therapiemodalitaeten" ], "offsets": [ [ 1554, 1574 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s1-r1-t3.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s1-r2-t2.1-t1.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s3-r1-t2.1-t3.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s3-r2-t3.1-t2.1", "type": "adjacent_to", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s3-r3-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s3-r4-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-r1-t1.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-r2-t4.1-t3.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-r3-t3.1-t2.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-r4-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-r5-t2.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-r6-t2.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s4-r7-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-r1-t1.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-r2-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-r3-t3.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-r4-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-r5-t1.1-t3.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-r6-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s6-r7-t3.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s7-r1-t3.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s7-r2-t3.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r1-t5.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r2-t2.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r3-t3.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r4-t1.1-t6.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r5-t5.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r6-t4.1-t5.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r7-t6.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r8-t1.1-t5.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r9-t7.1-t3.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r10-t5.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r11-t6.1-t7.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r12-t3.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r13-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r14-t3.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r15-t7.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r16-t5.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r17-t6.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r18-t6.1-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r19-t7.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r20-t7.1-t5.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t5", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r21-t4.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r22-t1.1-t7.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t1", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r23-t4.1-t6.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-r24-t7.2-t4.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t7", "arg2_id": "ZfuerRheumatologie.8057s027.ger.abstr-s9-t4", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s031.ger.abstr-passage-0", "type": "abstract", "text": [ "Chronische grossflaechige Schmerzen im muskuloskelettalen System werden seit der Antike berichtet . Die kritische klinische und experimentelle Forschung zu diesem Thema wurde jedoch erst in den letzten ein bis zwei Jahrzehnten intensiviert . Bezueglich vielfaeltiger Aspekte dieses Problems existieren kontroverse Vorstellungen : Klassifikation und Nosologie , kausale Mechanismen , Verlaeufe und Folgen sowie therapeutische Strategien . Das Fibromyalgie Syndrom ( FMS ) ist keine Krankheit im herkoemmlichen Sinne , sondern als eine funktionelle Stoerung anzusehen . Verschiedene typische Auspraegungen als auch disponierende Faktoren wurden bislang identifiziert . Unter diesen Gesichtspunkten ist fuer das Verstaendnis der komplexen multifaktoriellen Wechselwirkungen beim FMS eher ein neues biopsychosoziales Paradigma der personenbezogenen Dynamik erforderlich als die Suche nach einem spezifischen Agens oder Umweltfaktoren . Konzeptionelle Modelle zu Aetiologie und Forschungsmethoden sind bisland nur unzureichend entwickelt , um solche komplexen , multifaktoriellen Mechanismen zu untersuchen . Neue Wege der Forschung lassen verbesserte Behandlungsmethoden fuer FMS-Patienten erwarten ." ], "offsets": [ [ 0, 1196 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 26, 35 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 143, 152 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Klassifikation" ], "offsets": [ [ 330, 344 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008902" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 442, 454 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Syndrom" ], "offsets": [ [ 455, 462 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "Krankheit" ], "offsets": [ [ 481, 490 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012634" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "disponierende Faktoren" ], "offsets": [ [ 613, 635 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014024" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Umweltfaktoren" ], "offsets": [ [ 915, 929 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0014406" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Aetiologie" ], "offsets": [ [ 958, 968 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015127" } ] }, { "id": "ZfuerRheumatologie.8057s031.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Forschung" ], "offsets": [ [ 1118, 1127 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0035168" } ] } ]

[]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s036.ger.abstr-passage-0", "type": "abstract", "text": [ "Bei der Fibromyalgie beobachtet man in gleicher Weise wie bei unspezifischen chronischen Lumbalgien klinisch und roentgenologisch sehr haeufig Haltungsstoerungen der Wirbelsaeule , insbesondere Skoliosen . Darueber hinaus lassen sich ebenfalls bei beiden Erkrankungen in einem hohen Prozentsatz segmentale oder ausgedehnte Funktionsstoerungen des Achsenorgans nachweisen . Vermutlich sind die Wirbelsaeulenveraenderungen oft fuer die Erstmanifestation der Fibromyalgie verantwortlich , die sich ja meist monolokulaer vor allem in der Lumbal- und Cervicalregion findet . Die spaetere Ausbreitung der Schmerzen erfolgt wahrscheinlich auf neuralen und muskulaeren Wegen , wobei psychische Faktoren akzentuierend wirken duerften ." ], "offsets": [ [ 0, 726 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 8, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Wirbelsaeule" ], "offsets": [ [ 166, 178 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037949" } ] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Skoliosen" ], "offsets": [ [ 194, 203 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0036439" } ] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Wirbelsaeulenveraenderungen" ], "offsets": [ [ 393, 420 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037949" } ] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 456, 468 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 599, 608 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-r1-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s036.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-r2-t1.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s036.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-r3-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s036.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.8057s036.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-r4-t3.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s036.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s036.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s036.ger.abstr-s3-r1-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s036.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s036.ger.abstr-s3-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s047.ger.abstr-passage-0", "type": "abstract", "text": [ "Bei der Fibromyalgie finden sich morphologisch , insbesondere in laengergehenden Krankheitsstadien , mit konventionellen muskelbioptischen Methoden ueberwiegend unspezifische Befunde , wie eine Typ II-Faser-Atrophie , wie sie auch bei Inaktivitaetsatrophie , Affektionen der kortikospinalen Bahnen , steroidbedingter Atrophie und anderen neuromuskulaeren Stoerungen vorkommen , eine Mikroangiopathie und eine leichte Neutralfett- sowie Mitochondrienvermehrung . Einige der akkumulierten Mitochondrien zeigen eine abnorme Struktur . In eigenen Untersuchungen liessen sich in einem Teil der Faelle einzelne , sog . ragged red fibers nachweisen , denen in einigen Faellen Deletionen der mitochondrialen DNA zugeordnet werden konnten ." ], "offsets": [ [ 0, 731 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 8, 20 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "laengergehenden" ], "offsets": [ [ 65, 80 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0080331" } ] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Methoden" ], "offsets": [ [ 139, 147 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Inaktivitaetsatrophie" ], "offsets": [ [ 235, 256 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0752352" } ] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t5", "type": "umlsterm", "text": [ "steroidbedingter" ], "offsets": [ [ 300, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038317" } ] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "type": "umlsterm", "text": [ "Atrophie" ], "offsets": [ [ 317, 325 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004255" } ] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Mitochondrien" ], "offsets": [ [ 487, 500 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026237" } ] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "DNA" ], "offsets": [ [ 700, 703 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0012854" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r1-t2.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r2-t3.2-t6.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r3-t2.1-t3.2", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r4-t6.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r5-t5.1-t3.2", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r6-t5.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r7-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r8-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r9-t1.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r10-t3.1-t6.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r12-t6.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r13-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r14-t1.1-t6.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r15-t5.1-t6.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t5", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r16-t6.1-t1.1", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r17-t6.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r18-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r19-t3.2-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r20-t6.1-t3.2", "type": "degree_of", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t6", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r22-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r23-t3.2-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t3", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-r24-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s047.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s047.ger.abstr-s1-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s052.ger.abstr-passage-0", "type": "abstract", "text": [ "Einleitung : Das Fehlen von Daten zur Pathophysiologie der Fibromyalgie sowie von kranheitsspezifischen Laborparametern bereitet Schwierigkeiten , die Erkrankung als Entitaet anzuerkennen . Auf der Suche nach charakteristischen Merkmalen der Fibromyalgie bestimmten wir die Konzentration der Kollagen-Crosslinks im Urin und im Serum der Patienten . Methoden : Die Patienten mit Fibromyalgie wurden entsprechend den American College of Rheumatology-Klassifikationskriterien in die Studie eingeschlossen . Von 39 Fibromyalgie-Patienten und von 55 gesunden Kontrollpersonen wurden unter standardisierten Bedingungen Urin- und Serumproben genommen . Pyridinolin Pyd ) und Desoxypyridinolin ( ( Dpyd ) , lysyloxidasevermittelte Produkte und bindegewebs- und knochenumbaudeterminierende Marker des Kollagenstoffwechsels , wurden mittels HPLC detektiert . Hydroxyprolinspiegel ( Hyp ) , ein Marker des Kollagen-Turnover , wurden ebenfalls gemessen . Die Ergebnisse wurden auf den Kreatininspiegel normiert und der Pyd/Dpyd-Quotient gebildet . Ergebnisse : Die Pyd/Dpyd-Ratio in Urin und Serum und der Hyp-Spiegel im Urin waren bei den Fibromyalgie-Patienten im Vergleich zu den Kontrollpersonen signifikant vermindert . Schlussfolgerung : Die gefundenen , verminderten Kollagen-Crosslinks-Spiegel sind moeglicherweise auf ein Remodelling der extrazellulaeren Matrix und der Ausbildung von Kollagenablagerungen um preterminale Nervenfasern in der Haut von Fibromyalgie-Patienten ( abgesenkte Schmerzschwelle ? ) zurueckzufuehren . Die Analyse eines gestoerten Kollagenmetabolismus durch histologische Untersuchungen oder , besser , durch HPLC-Analyse der Kollagen-Crosslinks im Urin oder Serum kann moeglicherweise zum weiteren Verstaendnis der Pathogenese der Fibromyalgie beitragen ." ], "offsets": [ [ 0, 1777 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Pathophysiologie" ], "offsets": [ [ 38, 54 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0031847" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 59, 71 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 242, 254 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Konzentration" ], "offsets": [ [ 274, 287 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0086045" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Urin" ], "offsets": [ [ 315, 319 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 337, 346 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Methoden" ], "offsets": [ [ 349, 357 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025663" }, { "db_name": "UMLS", "db_id": "C0025664" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Patienten" ], "offsets": [ [ 364, 373 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030705" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 378, 390 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Urin-" ], "offsets": [ [ 613, 618 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "knochenumbaudeterminierende" ], "offsets": [ [ 753, 780 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005931" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t2", "type": "umlsterm", "text": [ "Marker" ], "offsets": [ [ 781, 787 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t3", "type": "umlsterm", "text": [ "Kollagenstoffwechsels" ], "offsets": [ [ 792, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009325" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t4", "type": "umlsterm", "text": [ "Kollagenstoffwechsels" ], "offsets": [ [ 792, 813 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025519" }, { "db_name": "UMLS", "db_id": "C0025520" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t5", "type": "umlsterm", "text": [ "HPLC" ], "offsets": [ [ 831, 835 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0008562" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Hydroxyprolinspiegel" ], "offsets": [ [ 849, 869 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0033382" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-t2", "type": "umlsterm", "text": [ "Marker" ], "offsets": [ [ 884, 890 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005516" }, { "db_name": "UMLS", "db_id": "C0001730" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Urin" ], "offsets": [ [ 1071, 1075 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Urin" ], "offsets": [ [ 1109, 1113 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t1", "type": "umlsterm", "text": [ "Ausbildung" ], "offsets": [ [ 1367, 1377 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0013622" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t2", "type": "umlsterm", "text": [ "Kollagenablagerungen" ], "offsets": [ [ 1382, 1402 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0009325" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t3", "type": "umlsterm", "text": [ "Nervenfasern" ], "offsets": [ [ 1419, 1431 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0027749" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "type": "umlsterm", "text": [ "Haut" ], "offsets": [ [ 1439, 1443 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t5", "type": "umlsterm", "text": [ "Schmerzschwelle" ], "offsets": [ [ 1484, 1499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162703" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t6", "type": "umlsterm", "text": [ "Schmerzschwelle" ], "offsets": [ [ 1484, 1499 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "type": "umlsterm", "text": [ "Analyse" ], "offsets": [ [ 1527, 1534 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0002778" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t2", "type": "umlsterm", "text": [ "Urin" ], "offsets": [ [ 1670, 1674 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0042036" } ] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 1753, 1765 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-r1-t2.1-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t2", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-r2-t1.1-t4.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-r3-t2.1-t1.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t2", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-r4-t1.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s2-r5-t1.1-t2.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-r1-t3.1-t1.2", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-r2-t1.2-t1.1", "type": "uses", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-r3-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s3-r4-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r1-t2.2-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r2-t2.2-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r3-t4.2-t3.1", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r4-t3.1-t2.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r5-t2.1-t4.2", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t2", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r6-t3.1-t4.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r7-t3.1-t1.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r8-t4.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r9-t4.2-t4.1", "type": "assesses_effect_of", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r10-t1.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r11-t1.1-t4.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-r12-t4.2-t2.2", "type": "analyzes", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s5-t4", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-r1-t2.2-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-t2", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-r2-t1.1-t2.2", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s6-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-r1-t1.1-t4.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-r2-t3.1-t4.1", "type": "part_of", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-r3-t3.1-t4.1", "type": "conceptual_part_of", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-r4-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-r5-t4.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-r6-t1.1-t3.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-r7-t6.1-t4.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t6", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s9-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-r1-t3.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-r2-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-r3-t1.1-t3.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-r4-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t1", "arg2_id": "ZfuerRheumatologie.8057s052.ger.abstr-s11-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s056.ger.abstr-passage-0", "type": "abstract", "text": [ "Der Rheumatologe muss sich oft mit chronischen Schmerzsyndromen befassen , die von der Fibromyalgie ( FM ) unterschieden werden muessen , auch wenn sie mit ihr gleichzeitig auftreten koennen . Ihre Verwechslung mit der FM liegt nahe 1. auf Grund des Auftretens generalisierter Schmerzen , 2. der Chronizitaet , 3. des bevorzugten Befalls von Frauen in einigen dieser Schmerzzustaende , und 4. des Fehlens objektivierbarer Befunde von bildgebenden Verfahren und labortechnischen Untersuchungen . Schmerz wird hervorgerufen durch die Stoerung normaler Funktionen ( \" Dysfunktionelle Syndrome \" , MASI , Ref. 6 ) . Die Diagnosestellung fusst auf der Untersuchung des Bewegungssystems nach biomechanischen Gesichtspunkten sowohl in Ruhe als auch Bewegung . Dementsprechend koennen dann Hyper- und Hypomobilitaetssyndrome unterschieden werden . Ihre Behandlung zielt auf die Normalisierung der biomechanischen Funktion ab . Ausserdem muss die Haut zur Erkennung einer Pannikulose ( \" Zellulitis \" ) untersucht werden ; eine Verwechslung mit der FM liegt wegen des bevorzugten Auftretens bei peri- und postmenopausalen Frauen nahe . Selbstverstaendlich muessen die vorgenannten Syndrome bei der Behandlung einer koinzidenten FM bzw. bei Studien zu FM angemessen beruecksichtigt werden ." ], "offsets": [ [ 0, 1280 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Schmerzsyndromen" ], "offsets": [ [ 47, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Schmerzsyndromen" ], "offsets": [ [ 47, 63 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 87, 99 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Schmerzen" ], "offsets": [ [ 277, 286 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 342, 348 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Schmerzzustaende" ], "offsets": [ [ 367, 383 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Schmerz" ], "offsets": [ [ 495, 502 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Dysfunktionelle" ], "offsets": [ [ 565, 580 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0041600" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Syndrome" ], "offsets": [ [ 581, 589 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Diagnosestellung" ], "offsets": [ [ 616, 632 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0348026" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s6-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 845, 855 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t1", "type": "umlsterm", "text": [ "Haut" ], "offsets": [ [ 938, 942 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037267" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t2", "type": "umlsterm", "text": [ "Erkennung" ], "offsets": [ [ 947, 956 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0025260" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "type": "umlsterm", "text": [ "Zellulitis" ], "offsets": [ [ 979, 989 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0007642" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t4", "type": "umlsterm", "text": [ "Frauen" ], "offsets": [ [ 1113, 1119 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0043210" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "type": "umlsterm", "text": [ "Syndrome" ], "offsets": [ [ 1172, 1180 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 1189, 1199 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s1-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s1-r2-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s1-r3-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s1-r4-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s3-r1-t2.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s3-r2-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s3-r3-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r1-t3.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r2-t1.1-t3.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r3-t1.1-t2.1", "type": "measurement_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r4-t3.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r5-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r6-t2.1-t3.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r7-t3.1-t2.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r8-t1.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r9-t1.1-t2.1", "type": "result_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r10-t3.1-t1.1", "type": "evaluation_of", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r11-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r12-t2.1-t1.1", "type": "affects", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-r13-t4.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t4", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s7-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-r1-t2.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-r2-t1.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t1", "arg2_id": "ZfuerRheumatologie.8057s056.ger.abstr-s8-t2", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s061.ger.abstr-passage-0", "type": "abstract", "text": [ "Obwohl die familiaere Haeufung des Fibromyalgie Syndroms FMS ) ( schon mehrfach beschrieben wurde , finden sich bislang nur wenige genetische Untersuchungen zu diesem Thema . So haben einige wenige Studien diese familiaere Haeufung zusammen mit einer Assoziation im HLA System berichtet . Unsere eigene Forschungsgruppe hat aktuell in einer Studie die Verbindung von Fibromyalgie Syndrom und HLA System in Familien mit mehrfach an FMS Erkrankten untersucht ." ], "offsets": [ [ 0, 458 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s061.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 35, 47 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s061.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Syndroms" ], "offsets": [ [ 48, 56 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s061.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Assoziation" ], "offsets": [ [ 251, 262 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0004083" } ] }, { "id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 367, 379 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-t2", "type": "umlsterm", "text": [ "Syndrom" ], "offsets": [ [ 380, 387 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-t3", "type": "umlsterm", "text": [ "Familien" ], "offsets": [ [ 406, 414 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0015576" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-r1-t1.1-t3.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-t1", "arg2_id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-r2-t2.1-t3.1", "type": "occurs_in", "arg1_id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-t2", "arg2_id": "ZfuerRheumatologie.8057s061.ger.abstr-s3-t3", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s063.ger.abstr-passage-0", "type": "abstract", "text": [ "Im Gegensatz zur Situation vor wenigen Jahren ist das heute international weitestgehend anerkannte Modell in der Pathogenese des Fibromyalgie Syndroms FMS ) ( eher das einer Stoerung zentralvenoeser Schmerzverarbeitung als das einer peripheren Muskelerkrankung . Abnormalitaeten der Serotoninspiegel aus Thrombozyten sowie von Substanz P im Liquor deuten auf Mechanismen der Erniedrigung der Schmerzschwelle hin . Inwieweit diese Mechanismen spezifisch fuer das FMS sind , wird die weitere Forschungsrichtung in der Zukunft bestimmen . Ein besseres Verstaendnis der Ursachen des FMS bedeutet auch einen Schritt vorwaerts in der Therapie dieser Erkrankung ." ], "offsets": [ [ 0, 656 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-t1", "type": "umlsterm", "text": [ "Fibromyalgie" ], "offsets": [ [ 129, 141 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0016053" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-t2", "type": "umlsterm", "text": [ "Syndroms" ], "offsets": [ [ 142, 150 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039082" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-t3", "type": "umlsterm", "text": [ "Schmerzverarbeitung" ], "offsets": [ [ 199, 218 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-t4", "type": "umlsterm", "text": [ "Muskelerkrankung" ], "offsets": [ [ 244, 260 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0026845" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Abnormalitaeten" ], "offsets": [ [ 263, 278 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0000768" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Thrombozyten" ], "offsets": [ [ 304, 316 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0005821" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t3", "type": "umlsterm", "text": [ "Schmerzschwelle" ], "offsets": [ [ 392, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0162703" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t4", "type": "umlsterm", "text": [ "Schmerzschwelle" ], "offsets": [ [ 392, 407 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t5", "type": "umlsterm", "text": [ "Substanz P" ], "offsets": [ [ 327, 337 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0038585" } ] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Therapie" ], "offsets": [ [ 628, 636 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" }, { "db_name": "UMLS", "db_id": "C0039798" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-r1-t1.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-r2-t4.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-r3-t3.1-t2.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-r4-t3.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t3", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-r5-t2.1-t4.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-r6-t2.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-r7-t1.1-t3.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s1-r8-t4.1-t2.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-r1-t5.1-t1.1", "type": "complicates", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-r2-t4.1-t1.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t4", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-r3-t5.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-r4-t2.1-t1.1", "type": "location_of", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-r5-t5.1-t1.1", "type": "causes", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t5", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-r6-t1.1-t4.1", "type": "associated_with", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s4-t1", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t4", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-r7-t2.1-t5.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t2", "arg2_id": "ZfuerRheumatologie.8057s063.ger.abstr-s2-t5", "normalized": [] } ]

[ { "id": "ZfuerRheumatologie.8057s072.ger.abstr-passage-0", "type": "abstract", "text": [ "Eine reduzierte Produktion von Wachtumshormonen ( GH ) wird bei 30% der Fibromyalgie-Patienten beobachtet . Die Behandlung dieser Fibromyalgie-Patienten mit rekombiniertem Wachstumshormon verbessert verschiedene klinische Symptome einschliesslich der Zahl der Hauptschmerzpunkte . Die reduzierte GH-Sekretion duerfte durch einen erhoehten Tonus der Somatostatin-Freisetzung im Hypothalamus bedingt sein . Es wird die Hypothese vorgestellt , dass diese gestoerte GH-Sekretion verursacht wird durch intermittierende Phasen erhoehter Cortisolspiegel , die wiederum die Dichte der -adrenergen Rezeptoren im Hypothalamus erhoehen . Die daraus resultierende Erhoehung des -adrenerrgen Tonus stimuliert die Freisetzung von Somatostatin mit der Folge der reduzierten GH-Sekretion ." ], "offsets": [ [ 0, 773 ] ] } ]

[ { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s2-t1", "type": "umlsterm", "text": [ "Behandlung" ], "offsets": [ [ 112, 122 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0039796" } ] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s2-t2", "type": "umlsterm", "text": [ "Hauptschmerzpunkte" ], "offsets": [ [ 260, 278 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0030193" } ] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s3-t1", "type": "umlsterm", "text": [ "Hypothalamus" ], "offsets": [ [ 377, 389 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020663" } ] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t1", "type": "umlsterm", "text": [ "Cortisolspiegel" ], "offsets": [ [ 531, 546 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020268" } ] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t2", "type": "umlsterm", "text": [ "Hypothalamus" ], "offsets": [ [ 603, 615 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0020663" } ] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t3", "type": "umlsterm", "text": [ "-adrenergen Rezeptoren" ], "offsets": [ [ 577, 599 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0034783" } ] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s5-t1", "type": "umlsterm", "text": [ "Somatostatin" ], "offsets": [ [ 716, 728 ] ], "normalized": [ { "db_name": "UMLS", "db_id": "C0037659" } ] } ]

[]

[]

[ { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s2-r1-t1.1-t2.1", "type": "treats", "arg1_id": "ZfuerRheumatologie.8057s072.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-r1-t2.1-t3.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t3", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-r2-t2.1-t1.1", "type": "produces", "arg1_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t2", "arg2_id": "ZfuerRheumatologie.8057s072.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-r3-t1.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s072.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-r4-t3.1-t1.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.8057s072.ger.abstr-s5-t1", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-r5-t3.1-t2.1", "type": "disrupts", "arg1_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t3", "arg2_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t2", "normalized": [] }, { "id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-r6-t1.1-t3.1", "type": "interacts_with", "arg1_id": "ZfuerRheumatologie.8057s072.ger.abstr-s5-t1", "arg2_id": "ZfuerRheumatologie.8057s072.ger.abstr-s4-t3", "normalized": [] } ]