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[ { "id": "NCT03467750_exc_text", "type": "exclusion", "text": [ "Known coagulation defect\nPatients on longstanding NSAID therapy\nKnown renal impairment\nPatients may also be excluded at the discretion of the investigator\n" ], "offsets": [ [ 0, 155 ] ] } ]

[ { "id": "NCT03467750_exc_T1", "type": "Condition", "text": [ "coagulation defect" ], "offsets": [ [ 6, 24 ] ], "normalized": [] }, { "id": "NCT03467750_exc_T2", "type": "Procedure", "text": [ "NSAID therapy" ], "offsets": [ [ 50, 63 ] ], "normalized": [] }, { "id": "NCT03467750_exc_T3", "type": "Temporal", "text": [ "longstanding" ], "offsets": [ [ 37, 49 ] ], "normalized": [] }, { "id": "NCT03467750_exc_T4", "type": "Condition", "text": [ "renal impairment" ], "offsets": [ [ 70, 86 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03467750_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03467750_exc_T2", "arg2_id": "NCT03467750_exc_T3", "normalized": [] } ]

[ { "id": "NCT03467750_inc_text", "type": "inclusion", "text": [ "Diagnosis of sleep disordered breathing or obstructive sleep apnea\nChildren undergoing elective tonsillectomy or adenotonsillectomy at Children's Healthcare of Atlanta Egleston location\nParent or legal guardian willing to participate, and able to understand and sign the provided informed consent\n" ], "offsets": [ [ 0, 297 ] ] } ]

[ { "id": "NCT03467750_inc_T1", "type": "Condition", "text": [ "sleep disordered breathing" ], "offsets": [ [ 13, 39 ] ], "normalized": [] }, { "id": "NCT03467750_inc_T2", "type": "Condition", "text": [ "obstructive sleep apnea" ], "offsets": [ [ 43, 66 ] ], "normalized": [] }, { "id": "NCT03467750_inc_T3", "type": "Person", "text": [ "Children" ], "offsets": [ [ 67, 75 ] ], "normalized": [] }, { "id": "NCT03467750_inc_T4", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 87, 95 ] ], "normalized": [] }, { "id": "NCT03467750_inc_T5", "type": "Procedure", "text": [ "tonsillectomy" ], "offsets": [ [ 96, 109 ] ], "normalized": [] }, { "id": "NCT03467750_inc_T6", "type": "Procedure", "text": [ "adenotonsillectomy" ], "offsets": [ [ 113, 131 ] ], "normalized": [] }, { "id": "NCT03467750_inc_T7", "type": "Scope", "text": [ "tonsillectomy or adenotonsillectomy" ], "offsets": [ [ 96, 131 ] ], "normalized": [] }, { "id": "NCT03467750_inc_T8", "type": "Visit", "text": [ "Children's Healthcare of Atlanta Egleston" ], "offsets": [ [ 135, 176 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03467750_inc_R1", "type": "AND", "arg1_id": "NCT03467750_inc_T7", "arg2_id": "NCT03467750_inc_T8", "normalized": [] }, { "id": "NCT03467750_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03467750_inc_T7", "arg2_id": "NCT03467750_inc_T4", "normalized": [] } ]

[ { "id": "NCT03471117_exc_text", "type": "exclusion", "text": [ "Allergy to Glitazones\nMyocardial infarction\nHeart failure\nAngina\nHistory of kidney stones\nLiver disease (abnormal liver enzymes)\nAnemia (hemoglobin <8 g/dl)\nCancer with current treatment\nPrevious organ transplantation\nImmunosuppressant therapy\nHuman immunodeficiency virus infection\nPregnancy or lactating\nCurrent tobacco use\nDilantin and oral contraceptive usage due to potential drug interaction with glitazones\nSelf-identified history of hypoglycemia\n" ], "offsets": [ [ 0, 454 ] ] } ]

[ { "id": "NCT03471117_exc_T1", "type": "Drug", "text": [ "Glitazones" ], "offsets": [ [ 11, 21 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T2", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T3", "type": "Condition", "text": [ "Myocardial infarction" ], "offsets": [ [ 22, 43 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T4", "type": "Condition", "text": [ "Heart failure" ], "offsets": [ [ 44, 57 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T5", "type": "Condition", "text": [ "Angina" ], "offsets": [ [ 58, 64 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T6", "type": "Condition", "text": [ "kidney stones" ], "offsets": [ [ 76, 89 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T7", "type": "Observation", "text": [ "History" ], "offsets": [ [ 65, 72 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T8", "type": "Condition", "text": [ "Liver disease" ], "offsets": [ [ 90, 103 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T9", "type": "Measurement", "text": [ "liver enzymes" ], "offsets": [ [ 114, 127 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T10", "type": "Value", "text": [ "abnormal" ], "offsets": [ [ 105, 113 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T11", "type": "Scope", "text": [ "abnormal liver enzymes" ], "offsets": [ [ 105, 127 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T12", "type": "Condition", "text": [ "Anemia" ], "offsets": [ [ 129, 135 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T13", "type": "Measurement", "text": [ "hemoglobin" ], "offsets": [ [ 137, 147 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T14", "type": "Value", "text": [ "<8 g/dl" ], "offsets": [ [ 148, 155 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T15", "type": "Scope", "text": [ "hemoglobin <8 g/dl" ], "offsets": [ [ 137, 155 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T16", "type": "Condition", "text": [ "Cancer" ], "offsets": [ [ 157, 163 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T17", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 177, 186 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T18", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 169, 176 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T19", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 187, 195 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T20", "type": "Procedure", "text": [ "organ transplantation" ], "offsets": [ [ 196, 217 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T21", "type": "Procedure", "text": [ "Immunosuppressant therapy" ], "offsets": [ [ 218, 243 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T22", "type": "Condition", "text": [ "Human immunodeficiency virus infection" ], "offsets": [ [ 244, 282 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T23", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 283, 292 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T24", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 296, 305 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T25", "type": "Observation", "text": [ "tobacco use" ], "offsets": [ [ 314, 325 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T26", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 306, 313 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T27", "type": "Drug", "text": [ "Dilantin" ], "offsets": [ [ 326, 334 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T28", "type": "Drug", "text": [ "oral contraceptive" ], "offsets": [ [ 339, 357 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T29", "type": "Condition", "text": [ "drug interaction" ], "offsets": [ [ 381, 397 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T30", "type": "Drug", "text": [ "glitazones" ], "offsets": [ [ 403, 413 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T31", "type": "Mood", "text": [ "potential" ], "offsets": [ [ 371, 380 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T32", "type": "Scope", "text": [ "Dilantin and oral contraceptive" ], "offsets": [ [ 326, 357 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T33", "type": "Condition", "text": [ "hypoglycemia" ], "offsets": [ [ 441, 453 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T34", "type": "Observation", "text": [ "history" ], "offsets": [ [ 430, 437 ] ], "normalized": [] }, { "id": "NCT03471117_exc_T35", "type": "Qualifier", "text": [ "Self-identified" ], "offsets": [ [ 414, 429 ] ], "normalized": [] } ]

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[ { "id": "NCT03471117_exc_R1", "type": "AND", "arg1_id": "NCT03471117_exc_T2", "arg2_id": "NCT03471117_exc_T1", "normalized": [] }, { "id": "NCT03471117_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03471117_exc_T6", "arg2_id": "NCT03471117_exc_T7", "normalized": [] }, { "id": "NCT03471117_exc_R3", "type": "Has_value", "arg1_id": "NCT03471117_exc_T9", "arg2_id": "NCT03471117_exc_T10", "normalized": [] }, { "id": "NCT03471117_exc_R4", "type": "Subsumes", "arg1_id": "NCT03471117_exc_T8", "arg2_id": "NCT03471117_exc_T11", "normalized": [] }, { "id": "NCT03471117_exc_R5", "type": "Has_value", "arg1_id": "NCT03471117_exc_T13", "arg2_id": "NCT03471117_exc_T14", "normalized": [] }, { "id": "NCT03471117_exc_R6", "type": "Subsumes", "arg1_id": "NCT03471117_exc_T12", "arg2_id": "NCT03471117_exc_T15", "normalized": [] }, { "id": "NCT03471117_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03471117_exc_T17", "arg2_id": "NCT03471117_exc_T18", "normalized": [] }, { "id": "NCT03471117_exc_R8", "type": "AND", "arg1_id": "NCT03471117_exc_T16", "arg2_id": "NCT03471117_exc_T17", "normalized": [] }, { "id": "NCT03471117_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03471117_exc_T20", "arg2_id": "NCT03471117_exc_T19", "normalized": [] }, { "id": "NCT03471117_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03471117_exc_T25", "arg2_id": "NCT03471117_exc_T26", "normalized": [] }, { "id": "NCT03471117_exc_R11", "type": "Has_mood", "arg1_id": "NCT03471117_exc_T29", "arg2_id": "NCT03471117_exc_T31", "normalized": [] }, { "id": "NCT03471117_exc_R12", "type": "AND", "arg1_id": "NCT03471117_exc_T32", "arg2_id": "NCT03471117_exc_T29", "normalized": [] }, { "id": "NCT03471117_exc_R13", "type": "AND", "arg1_id": "NCT03471117_exc_T29", "arg2_id": "NCT03471117_exc_T30", "normalized": [] }, { "id": "NCT03471117_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03471117_exc_T33", "arg2_id": "NCT03471117_exc_T34", "normalized": [] }, { "id": "NCT03471117_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT03471117_exc_T33", "arg2_id": "NCT03471117_exc_T35", "normalized": [] } ]

[ { "id": "NCT03471117_inc_text", "type": "inclusion", "text": [ "CKD patients classified as Stage 3 and 4 of National Kidney Foundation Classification with estimated glomerular filtration rate (GFR) between 15 and 59 mL/min/1.73 m2 according to the Modification of Diet in Renal Disease (MDRD) formula based on serum creatinine, age, gender, and race.\nMen and women 35 to 70 years of age\n" ], "offsets": [ [ 0, 323 ] ] } ]

[ { "id": "NCT03471117_inc_T1", "type": "Condition", "text": [ "CKD" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T2", "type": "Value", "text": [ "Stage 3" ], "offsets": [ [ 27, 34 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T3", "type": "Value", "text": [ "Stage", "4" ], "offsets": [ [ 27, 32 ], [ 39, 40 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T4", "type": "Scope", "text": [ "Stage 3 and 4" ], "offsets": [ [ 27, 40 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T5", "type": "Measurement", "text": [ "National Kidney Foundation Classification" ], "offsets": [ [ 44, 85 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T6", "type": "Measurement", "text": [ "estimated glomerular filtration rate (GFR)" ], "offsets": [ [ 91, 133 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T7", "type": "Value", "text": [ "between 15 and 59 mL/min/1.73 m2" ], "offsets": [ [ 134, 166 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T8", "type": "Qualifier", "text": [ "Modification of Diet in Renal Disease (MDRD) formula" ], "offsets": [ [ 184, 236 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T9", "type": "Person", "text": [ "Men" ], "offsets": [ [ 287, 290 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T10", "type": "Person", "text": [ "women" ], "offsets": [ [ 295, 300 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T11", "type": "Value", "text": [ "35 to 70 years" ], "offsets": [ [ 301, 315 ] ], "normalized": [] }, { "id": "NCT03471117_inc_T12", "type": "Person", "text": [ "age" ], "offsets": [ [ 319, 322 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03471117_inc_R1", "type": "Has_scope", "arg1_id": "NCT03471117_inc_T5", "arg2_id": "NCT03471117_inc_T4", "normalized": [] }, { "id": "NCT03471117_inc_R2", "type": "AND", "arg1_id": "NCT03471117_inc_T1", "arg2_id": "NCT03471117_inc_T5", "normalized": [] }, { "id": "NCT03471117_inc_R3", "type": "Has_value", "arg1_id": "NCT03471117_inc_T6", "arg2_id": "NCT03471117_inc_T7", "normalized": [] }, { "id": "NCT03471117_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03471117_inc_T6", "arg2_id": "NCT03471117_inc_T8", "normalized": [] }, { "id": "NCT03471117_inc_R5", "type": "Has_value", "arg1_id": "NCT03471117_inc_T12", "arg2_id": "NCT03471117_inc_T11", "normalized": [] } ]

[ { "id": "NCT03472495_exc_text", "type": "exclusion", "text": [ "Limited English proficiency (LEP)\nPregnant\nPrisoners\nWolff Parkinson White syndrome\nAdministration of electrical or chemical cardioversion before screening\nAdministration of other antiarrhythmics for acute heart rate control (excluding adenosine)\nHistory of allergy or idiosyncratic reaction to diltiazem\nUnable to take oral medications\nHeart rate <60 beats/min\n" ], "offsets": [ [ 0, 362 ] ] } ]

[ { "id": "NCT03472495_exc_T1", "type": "Observation", "text": [ "Limited English proficiency" ], "offsets": [ [ 0, 27 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T2", "type": "Observation", "text": [ "LEP" ], "offsets": [ [ 29, 32 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T3", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 34, 42 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T4", "type": "Person", "text": [ "Prisoners" ], "offsets": [ [ 43, 52 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T5", "type": "Condition", "text": [ "Wolff Parkinson White syndrome" ], "offsets": [ [ 53, 83 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T6", "type": "Procedure", "text": [ "chemical cardioversion" ], "offsets": [ [ 116, 138 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T7", "type": "Procedure", "text": [ "trical or", "ioversion bef" ], "offsets": [ [ 106, 115 ], [ 129, 142 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T8", "type": "Temporal", "text": [ "before screening" ], "offsets": [ [ 139, 155 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T9", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 146, 155 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T10", "type": "Scope", "text": [ "electrical or chemical cardioversion" ], "offsets": [ [ 102, 138 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T11", "type": "Drug", "text": [ "antiarrhythmics" ], "offsets": [ [ 180, 195 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T12", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 200, 205 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T13", "type": "Procedure", "text": [ "heart rate control" ], "offsets": [ [ 206, 224 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T14", "type": "Negation", "text": [ "excluding" ], "offsets": [ [ 226, 235 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T15", "type": "Drug", "text": [ "adenosine" ], "offsets": [ [ 236, 245 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T16", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 258, 265 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T17", "type": "Condition", "text": [ "idiosyncratic reaction" ], "offsets": [ [ 269, 291 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T18", "type": "Drug", "text": [ "diltiazem" ], "offsets": [ [ 295, 304 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T19", "type": "Scope", "text": [ "allergy or idiosyncratic reaction" ], "offsets": [ [ 258, 291 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T20", "type": "Condition", "text": [ "Unable to take" ], "offsets": [ [ 305, 319 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T21", "type": "Drug", "text": [ "oral medications" ], "offsets": [ [ 320, 336 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T22", "type": "Measurement", "text": [ "Heart rate" ], "offsets": [ [ 337, 347 ] ], "normalized": [] }, { "id": "NCT03472495_exc_T23", "type": "Value", "text": [ "<60 beats/min" ], "offsets": [ [ 348, 361 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03472495_exc_R1", "type": "Subsumes", "arg1_id": "NCT03472495_exc_T1", "arg2_id": "NCT03472495_exc_T2", "normalized": [] }, { "id": "NCT03472495_exc_R2", "type": "Has_index", "arg1_id": "NCT03472495_exc_T8", "arg2_id": "NCT03472495_exc_T9", "normalized": [] }, { "id": "NCT03472495_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03472495_exc_T10", "arg2_id": "NCT03472495_exc_T8", "normalized": [] }, { "id": "NCT03472495_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03472495_exc_T13", "arg2_id": "NCT03472495_exc_T12", "normalized": [] }, { "id": "NCT03472495_exc_R5", "type": "AND", "arg1_id": "NCT03472495_exc_T11", "arg2_id": "NCT03472495_exc_T13", "normalized": [] }, { "id": "NCT03472495_exc_R6", "type": "Has_negation", "arg1_id": "NCT03472495_exc_T15", "arg2_id": "NCT03472495_exc_T14", "normalized": [] }, { "id": "NCT03472495_exc_R7", "type": "AND", "arg1_id": "NCT03472495_exc_T11", "arg2_id": "NCT03472495_exc_T15", "normalized": [] }, { "id": "NCT03472495_exc_R8", "type": "AND", "arg1_id": "NCT03472495_exc_T19", "arg2_id": "NCT03472495_exc_T18", "normalized": [] }, { "id": "NCT03472495_exc_R9", "type": "AND", "arg1_id": "NCT03472495_exc_T21", "arg2_id": "NCT03472495_exc_T20", "normalized": [] }, { "id": "NCT03472495_exc_R10", "type": "Has_value", "arg1_id": "NCT03472495_exc_T22", "arg2_id": "NCT03472495_exc_T23", "normalized": [] } ]

[ { "id": "NCT03472495_inc_text", "type": "inclusion", "text": [ ">/= 18 years old\nAtrial fibrillation or flutter on electrocardiogram\nHeart rate >110 beats/min\nSystolic blood pressure >/= 90 mmHg\n" ], "offsets": [ [ 0, 131 ] ] } ]

[ { "id": "NCT03472495_inc_T1", "type": "Value", "text": [ ">/= 18 years old" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T2", "type": "Person", "text": [ "old" ], "offsets": [ [ 13, 16 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T3", "type": "Condition", "text": [ "Atrial fibrillation" ], "offsets": [ [ 17, 36 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T4", "type": "Condition", "text": [ "trial", "lutter" ], "offsets": [ [ 18, 23 ], [ 41, 47 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T5", "type": "Procedure", "text": [ "electrocardiogram" ], "offsets": [ [ 51, 68 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T6", "type": "Scope", "text": [ "Atrial fibrillation or flutter" ], "offsets": [ [ 17, 47 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T7", "type": "Measurement", "text": [ "Heart rate" ], "offsets": [ [ 69, 79 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T8", "type": "Value", "text": [ ">110 beats/min" ], "offsets": [ [ 80, 94 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T9", "type": "Measurement", "text": [ "Systolic blood pressure" ], "offsets": [ [ 95, 118 ] ], "normalized": [] }, { "id": "NCT03472495_inc_T10", "type": "Value", "text": [ ">/= 90 mmHg" ], "offsets": [ [ 119, 130 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03472495_inc_R1", "type": "Has_value", "arg1_id": "NCT03472495_inc_T2", "arg2_id": "NCT03472495_inc_T1", "normalized": [] }, { "id": "NCT03472495_inc_R2", "type": "Has_scope", "arg1_id": "NCT03472495_inc_T5", "arg2_id": "NCT03472495_inc_T6", "normalized": [] }, { "id": "NCT03472495_inc_R3", "type": "Has_value", "arg1_id": "NCT03472495_inc_T7", "arg2_id": "NCT03472495_inc_T8", "normalized": [] }, { "id": "NCT03472495_inc_R4", "type": "Has_value", "arg1_id": "NCT03472495_inc_T9", "arg2_id": "NCT03472495_inc_T10", "normalized": [] } ]

[ { "id": "NCT03472508_exc_text", "type": "exclusion", "text": [ "(1)Women who are pregnant and/or lactating; or women who intend to conceive within a year;\n(2)History of allergies to enalapril, folic acid or other components of the compound drug;\n(3)History of adverse reactions or intolerance to enalapril or other ACE inhibitors, or drugs or supplements containing folic acid;\n(4)Diagnosis or suspicion of secondary hypertension;\n(5)Known serious medical conditions, including: Cardiovascular: patients with clinically diagnosed cardiac dysfunction (NYHA class III and above), hypertrophic obstructive cardiomyopathy, clinically significant valvular heart disease, acute coronary syndrome within the last 3 months, or percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG); or abnormal pre-enrollment ECG test results with clinically significant arrhythmias (atrial flutter, atrial fibrillation, grade II-III atrioventricular block, etc.); Digestive: a previous diagnosis of various types of viral hepatitis that are still in the active phase; abnormal pre-enrollment liver function test results (ALT, AST, GGT, TBIL, or DBIL 3 times higher than normal, ALB = 30g/L); gastrectomy and/or gastrojejunostomy; gastrointestinal dysfunction; Urinary: pre-enrollment serum creatinine greater than 200umol/L; clinical diagnosis of renal artery stenosis, isolated kidney, kidney transplantation and/or other diseases; Endocrine: type 1 diabetes or uncontrolled type 2 diabetes (fasting blood glucose above 11.1 mmol/L at pre-enrollment); previous diagnosis of hyperthyroidism and failure to correct; Respiratory: pulmonary heart disease; chronic obstructive pulmonary disease; Neuropsychiatric: recent transient ischemic attack or stroke (within the last 3 months); peripheral or severe autonomic dysfunction; mental or nervous system dysfunction, inability to express desire; known drug or alcohol dependence; Malignancy, malnutrition, hematopoietic disorders and other serious diseases.\n(6)Significant signs of abnormalities as seen in laboratory tests or physical characteristics, which, at the discretion of the investigators, indicates that the patient is experiencing a serious illness or, may affect the observation and evaluation of the drug's efficacy or adverse events, or renders the patient unsuitable for participating in this study;\n(7)Patients currently taking folate, B12, or B6, or any compounds containing them, who express an inability or a refusal to stop usage;\n(8)Regular usage of folic acid supplements or compounds containing folic acid in the past 3 months;\n(9)Participation in a clinical trial for a drug that has not yet been officially approved for marketing within one month prior to the first visit.\n" ], "offsets": [ [ 0, 2684 ] ] } ]

[ { "id": "NCT03472508_exc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 3, 8 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T2", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 17, 25 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T3", "type": "Observation", "text": [ "lactating" ], "offsets": [ [ 33, 42 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T4", "type": "Person", "text": [ "women" ], "offsets": [ [ 47, 52 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T5", "type": "Observation", "text": [ "intend to conceive" ], "offsets": [ [ 57, 75 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T6", "type": "Temporal", "text": [ "within a year" ], "offsets": [ [ 76, 89 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T7", "type": "Scope", "text": [ "women who intend to conceive within a year" ], "offsets": [ [ 47, 89 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T8", "type": "Scope", "text": [ "Women who are pregnant and/or lactating" ], "offsets": [ [ 3, 42 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T9", "type": "Observation", "text": [ "History" ], "offsets": [ [ 94, 101 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T10", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 105, 114 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T11", "type": "Drug", "text": [ "enalapril" ], "offsets": [ [ 118, 127 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T12", "type": "Drug", "text": [ "folic acid" ], "offsets": [ [ 129, 139 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T13", "type": "Drug", "text": [ "components of the compound drug" ], "offsets": [ [ 149, 180 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T14", "type": "Scope", "text": [ "enalapril, folic acid or other components of the compound drug" ], "offsets": [ [ 118, 180 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T15", "type": "Observation", "text": [ "History" ], "offsets": [ [ 185, 192 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T16", "type": "Condition", "text": [ "adverse reactions" ], "offsets": [ [ 196, 213 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T17", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 217, 228 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T18", "type": "Drug", "text": [ "enalapril" ], "offsets": [ [ 232, 241 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T19", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 245, 250 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T20", "type": "Drug", "text": [ "ACE inhibitors" ], "offsets": [ [ 251, 265 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T21", "type": "Drug", "text": [ "folic acid" ], "offsets": [ [ 302, 312 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T22", "type": "Scope", "text": [ "adverse reactions or intolerance" ], "offsets": [ [ 196, 228 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T23", "type": "Scope", "text": [ "enalapril or other ACE inhibitors, or drugs or supplements containing folic acid" ], "offsets": [ [ 232, 312 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T24", "type": "Condition", "text": [ "secondary hypertension" ], "offsets": [ [ 343, 365 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T25", "type": "Mood", "text": [ "suspicion" ], "offsets": [ [ 330, 339 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T26", "type": "Mood", "text": [ "Diagnosis" ], "offsets": [ [ 317, 326 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T27", "type": "Scope", "text": [ "Diagnosis or suspicion" ], "offsets": [ [ 317, 339 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T28", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 376, 383 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T29", "type": "Condition", "text": [ "medical conditions" ], "offsets": [ [ 384, 402 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T31", "type": "Condition", "text": [ "cardiac dysfunction" ], "offsets": [ [ 466, 485 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T32", "type": "Qualifier", "text": [ "clinically diagnosed" ], "offsets": [ [ 445, 465 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T33", "type": "Measurement", "text": [ "NYHA class" ], "offsets": [ [ 487, 497 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T34", "type": "Value", "text": [ "III and above" ], "offsets": [ [ 498, 511 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T35", "type": "Scope", "text": [ "NYHA class III and above" ], "offsets": [ [ 487, 511 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T36", "type": "Condition", "text": [ "hypertrophic obstructive cardiomyopathy" ], "offsets": [ [ 514, 553 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T30", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 555, 577 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T37", "type": "Condition", "text": [ "valvular heart disease" ], "offsets": [ [ 578, 600 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T38", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 602, 625 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T39", "type": "Temporal", "text": [ "within the last 3 months" ], "offsets": [ [ 626, 650 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T40", "type": "Procedure", "text": [ "percutaneous coronary intervention (PCI)" ], "offsets": [ [ 655, 695 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T41", "type": "Procedure", "text": [ "coronary artery bypass graft (CABG)" ], "offsets": [ [ 700, 735 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T42", "type": "Value", "text": [ "abnormal" ], "offsets": [ [ 740, 748 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T43", "type": "Temporal", "text": [ "pre-enrollment" ], "offsets": [ [ 749, 763 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T44", "type": "Measurement", "text": [ "ECG test" ], "offsets": [ [ 764, 772 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T45", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 786, 808 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T46", "type": "Condition", "text": [ "arrhythmias" ], "offsets": [ [ 809, 820 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T47", "type": "Condition", "text": [ "atrial flutter" ], "offsets": [ [ 822, 836 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T48", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 838, 857 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T49", "type": "Condition", "text": [ "atrioventricular block" ], "offsets": [ [ 872, 894 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T50", "type": "Qualifier", "text": [ "grade II" ], "offsets": [ [ 859, 867 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T51", "type": "Qualifier", "text": [ "e II-", "atr" ], "offsets": [ [ 863, 868 ], [ 872, 875 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T52", "type": "Scope", "text": [ "grade II-III" ], "offsets": [ [ 859, 871 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T53", "type": "Scope", "text": [ "atrial flutter, atrial fibrillation, grade II-III atrioventricular block" ], "offsets": [ [ 822, 894 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T54", "type": "Scope", "text": [ "clinically significant arrhythmias" ], "offsets": [ [ 786, 820 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T55", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 916, 924 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T56", "type": "Condition", "text": [ "viral hepatitis" ], "offsets": [ [ 955, 970 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T57", "type": "Qualifier", "text": [ "active phase" ], "offsets": [ [ 993, 1005 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T58", "type": "Value", "text": [ "abnormal" ], "offsets": [ [ 1007, 1015 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T59", "type": "Measurement", "text": [ "liver function test" ], "offsets": [ [ 1031, 1050 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T60", "type": "Temporal", "text": [ "pre-enrollment" ], "offsets": [ [ 1016, 1030 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T61", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 1060, 1063 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T62", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 1065, 1068 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T63", "type": "Measurement", "text": [ "GGT" ], "offsets": [ [ 1070, 1073 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T64", "type": "Measurement", "text": [ "TBIL" ], "offsets": [ [ 1075, 1079 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T65", "type": "Measurement", "text": [ "DBIL" ], "offsets": [ [ 1084, 1088 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T66", "type": "Value", "text": [ "3 times higher than normal" ], "offsets": [ [ 1089, 1115 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T67", "type": "Scope", "text": [ "ALT, AST, GGT, TBIL, or DBIL" ], "offsets": [ [ 1060, 1088 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T68", "type": "Measurement", "text": [ "ALB" ], "offsets": [ [ 1117, 1120 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T69", "type": "Value", "text": [ "= 30g/L" ], "offsets": [ [ 1121, 1128 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T70", "type": "Procedure", "text": [ "gastrectomy" ], "offsets": [ [ 1131, 1142 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T71", "type": "Procedure", "text": [ "gastrojejunostomy" ], "offsets": [ [ 1150, 1167 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T72", "type": "Condition", "text": [ "gastrointestinal dysfunction" ], "offsets": [ [ 1169, 1197 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T73", "type": "Temporal", "text": [ "pre-enrollment" ], "offsets": [ [ 1208, 1222 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T74", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 1223, 1239 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T75", "type": "Value", "text": [ "greater than 200umol/L" ], "offsets": [ [ 1240, 1262 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T76", "type": "Qualifier", "text": [ "clinical diagnosis" ], "offsets": [ [ 1264, 1282 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T77", "type": "Condition", "text": [ "renal artery stenosis" ], "offsets": [ [ 1286, 1307 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T78", "type": "Procedure", "text": [ "kidney transplantation" ], "offsets": [ [ 1326, 1348 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T79", "type": "Condition", "text": [ "isolated kidney" ], "offsets": [ [ 1309, 1324 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T80", "type": "Condition", "text": [ "type 1 diabetes" ], "offsets": [ [ 1383, 1398 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T81", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 1402, 1414 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T82", "type": "Condition", "text": [ "type 2 diabetes" ], "offsets": [ [ 1415, 1430 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T83", "type": "Measurement", "text": [ "fasting blood glucose" ], "offsets": [ [ 1432, 1453 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T84", "type": "Value", "text": [ "above 11.1 mmol/L" ], "offsets": [ [ 1454, 1471 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T85", "type": "Temporal", "text": [ "at pre-enrollment" ], "offsets": [ [ 1472, 1489 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T86", "type": "Reference_point", "text": [ "pre-enrollment" ], "offsets": [ [ 1475, 1489 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T87", "type": "Scope", "text": [ "fasting blood glucose above 11.1 mmol/L at pre-enrollment" ], "offsets": [ [ 1432, 1489 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T88", "type": "Scope", "text": [ "uncontrolled type 2 diabetes" ], "offsets": [ [ 1402, 1430 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T89", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 1492, 1500 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T90", "type": "Condition", "text": [ "hyperthyroidism" ], "offsets": [ [ 1514, 1529 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T91", "type": "Observation", "text": [ "failure to correct" ], "offsets": [ [ 1534, 1552 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T92", "type": "Condition", "text": [ "pulmonary heart disease" ], "offsets": [ [ 1567, 1590 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T93", "type": "Condition", "text": [ "chronic obstructive pulmonary disease" ], "offsets": [ [ 1592, 1629 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T94", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 1649, 1655 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T95", "type": "Condition", "text": [ "transient ischemic attack" ], "offsets": [ [ 1656, 1681 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T96", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 1685, 1691 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T97", "type": "Temporal", "text": [ "within the last 3 months" ], "offsets": [ [ 1693, 1717 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T98", "type": "Scope", "text": [ "transient ischemic attack or stroke" ], "offsets": [ [ 1656, 1691 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T99", "type": "Qualifier", "text": [ "peripheral" ], "offsets": [ [ 1720, 1730 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T100", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1734, 1740 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T101", "type": "Condition", "text": [ "autonomic dysfunction" ], "offsets": [ [ 1741, 1762 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T102", "type": "Scope", "text": [ "peripheral or severe" ], "offsets": [ [ 1720, 1740 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T103", "type": "Condition", "text": [ "al or", "em dysfunction, in" ], "offsets": [ [ 1768, 1773 ], [ 1786, 1804 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T104", "type": "Condition", "text": [ "nervous system dysfunction" ], "offsets": [ [ 1774, 1800 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T105", "type": "Scope", "text": [ "ALT, AST, GGT, TBIL, or DBIL 3 times higher than normal, ALB = 30g/L" ], "offsets": [ [ 1060, 1128 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T106", "type": "Observation", "text": [ "inability to express desire" ], "offsets": [ [ 1802, 1829 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T107", "type": "Condition", "text": [ " o", "ndence; Ma" ], "offsets": [ [ 1841, 1843 ], [ 1857, 1867 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T108", "type": "Condition", "text": [ "alcohol dependence" ], "offsets": [ [ 1845, 1863 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T109", "type": "Condition", "text": [ "Malignancy" ], "offsets": [ [ 1865, 1875 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T110", "type": "Condition", "text": [ "malnutrition" ], "offsets": [ [ 1877, 1889 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T111", "type": "Condition", "text": [ "hematopoietic disorders" ], "offsets": [ [ 1891, 1914 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T112", "type": "Scope", "text": [ "clinically diagnosed cardiac dysfunction (NYHA class III and above), hypertrophic obstructive cardiomyopathy, clinically significant valvular heart disease, acute coronary syndrome within the last 3 months, or percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG); or abnormal pre-enrollment ECG test results with clinically significant arrhythmias (atrial flutter, atrial fibrillation, grade II-III atrioventricular block, etc.); Digestive: a previous diagnosis of various types of viral hepatitis that are still in the active phase; abnormal pre-enrollment liver function test results (ALT, AST, GGT, TBIL, or DBIL 3 times higher than normal, ALB = 30g/L); gastrectomy and/or gastrojejunostomy; gastrointestinal dysfunction; Urinary: pre-enrollment serum creatinine greater than 200umol/L; clinical diagnosis of renal artery stenosis, isolated kidney, kidney transplantation and/or other diseases; Endocrine: type 1 diabetes or uncontrolled type 2 diabetes (fasting blood glucose above 11.1 mmol/L at pre-enrollment); previous diagnosis of hyperthyroidism and failure to correct; Respiratory: pulmonary heart disease; chronic obstructive pulmonary disease; Neuropsychiatric: recent transient ischemic attack or stroke (within the last 3 months); peripheral or severe autonomic dysfunction; mental or nervous system dysfunction, inability to express desire; known drug or alcohol dependence; Malignancy, malnutrition, hematopoietic disorders" ], "offsets": [ [ 445, 1914 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T113", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1946, 1957 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T114", "type": "Condition", "text": [ "signs of abnormalities" ], "offsets": [ [ 1958, 1980 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T115", "type": "Measurement", "text": [ "laboratory tests" ], "offsets": [ [ 1992, 2008 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T117", "type": "Drug", "text": [ "folate" ], "offsets": [ [ 2330, 2336 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T118", "type": "Drug", "text": [ "B12" ], "offsets": [ [ 2338, 2341 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T119", "type": "Drug", "text": [ "B6" ], "offsets": [ [ 2346, 2348 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T120", "type": "Observation", "text": [ "refusal to stop usage" ], "offsets": [ [ 2414, 2435 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T121", "type": "Observation", "text": [ "inability" ], "offsets": [ [ 2399, 2408 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T122", "type": "Temporal", "text": [ "currently" ], "offsets": [ [ 2313, 2322 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T123", "type": "Scope", "text": [ "folate, B12, or B6" ], "offsets": [ [ 2330, 2348 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T124", "type": "Drug", "text": [ "folic acid supplements" ], "offsets": [ [ 2457, 2479 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T125", "type": "Multiplier", "text": [ "Regular usage" ], "offsets": [ [ 2440, 2453 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T126", "type": "Drug", "text": [ "compounds containing folic acid" ], "offsets": [ [ 2483, 2514 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T127", "type": "Temporal", "text": [ "in the past 3 months" ], "offsets": [ [ 2515, 2535 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T128", "type": "Scope", "text": [ "folic acid supplements or compounds containing folic acid" ], "offsets": [ [ 2457, 2514 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T129", "type": "Scope", "text": [ " usage of fo", "past 3 months;\n(9)Pa" ], "offsets": [ [ 2447, 2459 ], [ 2522, 2542 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T130", "type": "Observation", "text": [ "Participation in a clinical trial" ], "offsets": [ [ 2540, 2573 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T131", "type": "Drug", "text": [ "drug that has not yet been officially approved for marketing" ], "offsets": [ [ 2580, 2640 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T132", "type": "Temporal", "text": [ "within one month prior to the first visit" ], "offsets": [ [ 2641, 2682 ] ], "normalized": [] }, { "id": "NCT03472508_exc_T133", "type": "Reference_point", "text": [ "the first visit" ], "offsets": [ [ 2667, 2682 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03472508_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T5", "arg2_id": "NCT03472508_exc_T6", "normalized": [] }, { "id": "NCT03472508_exc_R2", "type": "Has_scope", "arg1_id": "NCT03472508_exc_T10", "arg2_id": "NCT03472508_exc_T14", "normalized": [] }, { "id": "NCT03472508_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T10", "arg2_id": "NCT03472508_exc_T9", "normalized": [] }, { "id": "NCT03472508_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T20", "arg2_id": "NCT03472508_exc_T19", "normalized": [] }, { "id": "NCT03472508_exc_R5", "type": "Has_scope", "arg1_id": "NCT03472508_exc_T22", "arg2_id": "NCT03472508_exc_T23", "normalized": [] }, { "id": "NCT03472508_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T22", "arg2_id": "NCT03472508_exc_T15", "normalized": [] }, { "id": "NCT03472508_exc_R7", "type": "Has_scope", "arg1_id": "NCT03472508_exc_T24", "arg2_id": "NCT03472508_exc_T27", "normalized": [] }, { "id": "NCT03472508_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T29", "arg2_id": "NCT03472508_exc_T28", "normalized": [] }, { "id": "NCT03472508_exc_R9", "type": "Has_value", "arg1_id": "NCT03472508_exc_T33", "arg2_id": "NCT03472508_exc_T34", "normalized": [] }, { "id": "NCT03472508_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T31", "arg2_id": "NCT03472508_exc_T32", "normalized": [] }, { "id": "NCT03472508_exc_R11", "type": "Subsumes", "arg1_id": "NCT03472508_exc_T31", "arg2_id": "NCT03472508_exc_T35", "normalized": [] }, { "id": "NCT03472508_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T38", "arg2_id": "NCT03472508_exc_T39", "normalized": [] }, { "id": "NCT03472508_exc_R13", "type": "Has_value", "arg1_id": "NCT03472508_exc_T44", "arg2_id": "NCT03472508_exc_T42", "normalized": [] }, { "id": "NCT03472508_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T44", "arg2_id": "NCT03472508_exc_T43", "normalized": [] }, { "id": "NCT03472508_exc_R15", "type": "Has_scope", "arg1_id": "NCT03472508_exc_T49", "arg2_id": "NCT03472508_exc_T52", "normalized": [] }, { "id": "NCT03472508_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T46", "arg2_id": "NCT03472508_exc_T45", "normalized": [] }, { "id": "NCT03472508_exc_R17", "type": "Subsumes", "arg1_id": "NCT03472508_exc_T54", "arg2_id": "NCT03472508_exc_T53", "normalized": [] }, { "id": "NCT03472508_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T56", "arg2_id": "NCT03472508_exc_T57", "normalized": [] }, { "id": "NCT03472508_exc_R19", "type": "Has_value", "arg1_id": "NCT03472508_exc_T59", "arg2_id": "NCT03472508_exc_T58", "normalized": [] }, { "id": "NCT03472508_exc_R20", "type": "Has_value", "arg1_id": "NCT03472508_exc_T67", "arg2_id": "NCT03472508_exc_T66", "normalized": [] }, { "id": "NCT03472508_exc_R21", "type": "Has_value", "arg1_id": "NCT03472508_exc_T68", "arg2_id": "NCT03472508_exc_T69", "normalized": [] }, { "id": "NCT03472508_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T59", "arg2_id": "NCT03472508_exc_T60", "normalized": [] }, { "id": "NCT03472508_exc_R23", "type": "Has_value", "arg1_id": "NCT03472508_exc_T74", "arg2_id": "NCT03472508_exc_T75", "normalized": [] }, { "id": "NCT03472508_exc_R24", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T74", "arg2_id": "NCT03472508_exc_T73", "normalized": [] }, { "id": "NCT03472508_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T77", "arg2_id": "NCT03472508_exc_T76", "normalized": [] }, { "id": "NCT03472508_exc_R26", "type": "Has_value", "arg1_id": "NCT03472508_exc_T83", "arg2_id": "NCT03472508_exc_T84", "normalized": [] }, { "id": "NCT03472508_exc_R27", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T83", "arg2_id": "NCT03472508_exc_T85", "normalized": [] }, { "id": "NCT03472508_exc_R28", "type": "Has_index", "arg1_id": "NCT03472508_exc_T85", "arg2_id": "NCT03472508_exc_T86", "normalized": [] }, { "id": "NCT03472508_exc_R29", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T82", "arg2_id": "NCT03472508_exc_T81", "normalized": [] }, { "id": "NCT03472508_exc_R30", "type": "Subsumes", "arg1_id": "NCT03472508_exc_T88", "arg2_id": "NCT03472508_exc_T87", "normalized": [] }, { "id": "NCT03472508_exc_R32", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T90", "arg2_id": "NCT03472508_exc_T89", "normalized": [] }, { "id": "NCT03472508_exc_R33", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T98", "arg2_id": "NCT03472508_exc_T97", "normalized": [] }, { "id": "NCT03472508_exc_R34", "type": "Has_scope", "arg1_id": "NCT03472508_exc_T101", "arg2_id": "NCT03472508_exc_T102", "normalized": [] }, { "id": "NCT03472508_exc_R35", "type": "Subsumes", "arg1_id": "NCT03472508_exc_T97", "arg2_id": "NCT03472508_exc_T94", "normalized": [] }, { "id": "NCT03472508_exc_R36", "type": "Subsumes", "arg1_id": "NCT03472508_exc_T59", "arg2_id": "NCT03472508_exc_T105", "normalized": [] }, { "id": "NCT03472508_exc_R37", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T56", "arg2_id": "NCT03472508_exc_T55", "normalized": [] }, { "id": "NCT03472508_exc_R38", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T37", "arg2_id": "NCT03472508_exc_T30", "normalized": [] }, { "id": "NCT03472508_exc_R39", "type": "Has_scope", "arg1_id": "NCT03472508_exc_T44", "arg2_id": "NCT03472508_exc_T54", "normalized": [] }, { "id": "NCT03472508_exc_R40", "type": "Subsumes", "arg1_id": "NCT03472508_exc_T29", "arg2_id": "NCT03472508_exc_T112", "normalized": [] }, { "id": "NCT03472508_exc_R41", "type": "AND", "arg1_id": "NCT03472508_exc_T115", "arg2_id": "NCT03472508_exc_T114", "normalized": [] }, { "id": "NCT03472508_exc_R42", "type": "Has_qualifier", "arg1_id": "NCT03472508_exc_T114", "arg2_id": "NCT03472508_exc_T113", "normalized": [] }, { "id": "NCT03472508_exc_R43", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T123", "arg2_id": "NCT03472508_exc_T122", "normalized": [] }, { "id": "NCT03472508_exc_R44", "type": "Has_scope", "arg1_id": "NCT03472508_exc_T128", "arg2_id": "NCT03472508_exc_T129", "normalized": [] }, { "id": "NCT03472508_exc_R45", "type": "AND", "arg1_id": "NCT03472508_exc_T130", "arg2_id": "NCT03472508_exc_T131", "normalized": [] }, { "id": "NCT03472508_exc_R46", "type": "Has_temporal", "arg1_id": "NCT03472508_exc_T130", "arg2_id": "NCT03472508_exc_T132", "normalized": [] }, { "id": "NCT03472508_exc_R47", "type": "Has_index", "arg1_id": "NCT03472508_exc_T132", "arg2_id": "NCT03472508_exc_T133", "normalized": [] } ]

[ { "id": "NCT03472508_inc_text", "type": "inclusion", "text": [ "(1)= 45 years old;\n(2)A diagnosis or previous diagnosis of essential hypertension, including anyone currently taking antihypertensive drugs; or for those who have not taken antihypertensive drugs within the last 2 weeks, two consecutive examinations were conducted at least one day apart, and both sitting blood pressure (mean value of 3 measurements) met the following criteria: diastolic blood pressure (DBP) =90 mmHg or systolic blood pressure (SBP) =140 mmHg (the second blood pressure was measured at V1);\n(3)If a study participant is a woman of childbearing age, she agrees to use a reliable contraceptive method during the trial;\n(4)Voluntarily participates and has signed an informed consent form.\n(1)Completed MTHFR C677T gene polymorphism detection in run-in period or MTHFR C677T genotype already known in advance;\n(2)Exhibited good tolerance to enalapril and good overall medication compliance (>80%) in run-in period or previously exhibited good tolerance and adherence to ACEI drugs in previous medication history.\n(3)Voluntarily continues to participate in this study.\n" ], "offsets": [ [ 0, 1084 ] ] } ]

[ { "id": "NCT03472508_inc_T1", "type": "Value", "text": [ "= 45 years" ], "offsets": [ [ 3, 13 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T2", "type": "Person", "text": [ "old" ], "offsets": [ [ 14, 17 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T3", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 37, 45 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T4", "type": "Mood", "text": [ "diagnosis" ], "offsets": [ [ 24, 33 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T5", "type": "Condition", "text": [ "essential hypertension" ], "offsets": [ [ 59, 81 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T6", "type": "Scope", "text": [ "diagnosis or previous" ], "offsets": [ [ 24, 45 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T7", "type": "Drug", "text": [ "antihypertensive drugs" ], "offsets": [ [ 117, 139 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T8", "type": "Drug", "text": [ "antihypertensive drugs" ], "offsets": [ [ 173, 195 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T9", "type": "Negation", "text": [ "not" ], "offsets": [ [ 163, 166 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T10", "type": "Temporal", "text": [ "within the last 2 weeks" ], "offsets": [ [ 196, 219 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T11", "type": "Multiplier", "text": [ "wo consecutive", "t least one day apart," ], "offsets": [ [ 222, 236 ], [ 266, 288 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T12", "type": "Procedure", "text": [ "sitting blood pressure" ], "offsets": [ [ 298, 320 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T13", "type": "Measurement", "text": [ "diastolic blood pressure (DBP)" ], "offsets": [ [ 380, 410 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T14", "type": "Value", "text": [ "=90 mmHg" ], "offsets": [ [ 411, 419 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T15", "type": "Measurement", "text": [ "systolic blood pressure (SBP)" ], "offsets": [ [ 423, 452 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T16", "type": "Value", "text": [ "=140 mmHg" ], "offsets": [ [ 453, 462 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T17", "type": "Scope", "text": [ "diastolic blood pressure (DBP) =90 mmHg or systolic blood pressure (SBP) =140 mmHg" ], "offsets": [ [ 380, 462 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T18", "type": "Temporal", "text": [ "currently" ], "offsets": [ [ 100, 109 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T19", "type": "Scope", "text": [ "not taken antihypertensive drugs within the last 2 weeks" ], "offsets": [ [ 163, 219 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T20", "type": "Scope", "text": [ "currently taking antihypertensive drugs" ], "offsets": [ [ 100, 139 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T21", "type": "Scope", "text": [ "two consecutive examinations were conducted at least one day apart, and both sitting blood pressure (mean value of 3 measurements) met the following criteria: diastolic blood pressure (DBP) =90 mmHg or systolic blood pressure (SBP) =140 mmHg" ], "offsets": [ [ 221, 462 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T23", "type": "Person", "text": [ "woman" ], "offsets": [ [ 542, 547 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T24", "type": "Observation", "text": [ "childbearing age" ], "offsets": [ [ 551, 567 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T25", "type": "Scope", "text": [ "woman of childbearing age" ], "offsets": [ [ 542, 567 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T26", "type": "Qualifier", "text": [ "reliable" ], "offsets": [ [ 589, 597 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T27", "type": "Observation", "text": [ "contraceptive method" ], "offsets": [ [ 598, 618 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T28", "type": "Temporal", "text": [ "during the trial" ], "offsets": [ [ 619, 635 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T29", "type": "Reference_point", "text": [ "the trial" ], "offsets": [ [ 626, 635 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T30", "type": "Mood", "text": [ "agrees to use" ], "offsets": [ [ 573, 586 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T31", "type": "Observation", "text": [ "signed an informed consent" ], "offsets": [ [ 673, 699 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T32", "type": "Observation", "text": [ "Voluntarily participates" ], "offsets": [ [ 640, 664 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T33", "type": "Procedure", "text": [ "gene polymorphism detection" ], "offsets": [ [ 731, 758 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T34", "type": "Observation", "text": [ "genotype already known" ], "offsets": [ [ 791, 813 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T35", "type": "Qualifier", "text": [ "MTHFR C677T" ], "offsets": [ [ 779, 790 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T36", "type": "Qualifier", "text": [ "MTHFR C677T" ], "offsets": [ [ 719, 730 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T37", "type": "Condition", "text": [ "good tolerance to enalapril" ], "offsets": [ [ 839, 866 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T38", "type": "Drug", "text": [ "enalapril" ], "offsets": [ [ 857, 866 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T39", "type": "Measurement", "text": [ "overall medication compliance" ], "offsets": [ [ 876, 905 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T40", "type": "Value", "text": [ "good" ], "offsets": [ [ 871, 875 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T41", "type": "Value", "text": [ ">80%" ], "offsets": [ [ 907, 911 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T42", "type": "Temporal", "text": [ "previously" ], "offsets": [ [ 933, 943 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T43", "type": "Condition", "text": [ "tolerance and", "EI drugs in p" ], "offsets": [ [ 959, 972 ], [ 988, 1001 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T44", "type": "Drug", "text": [ "ACEI drugs" ], "offsets": [ [ 986, 996 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T45", "type": "Observation", "text": [ "tole", "ence to ACEI drugs in p" ], "offsets": [ [ 959, 963 ], [ 978, 1001 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T46", "type": "Observation", "text": [ "medication history" ], "offsets": [ [ 1009, 1027 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T47", "type": "Scope", "text": [ "good tolerance and adherence to ACEI drugs" ], "offsets": [ [ 954, 996 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T48", "type": "Scope", "text": [ "good tolerance to enalapril and good overall medication compliance (>80%) in run-in period" ], "offsets": [ [ 839, 929 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T49", "type": "Observation", "text": [ "continues to participate in this study" ], "offsets": [ [ 1044, 1082 ] ], "normalized": [] }, { "id": "NCT03472508_inc_T50", "type": "Qualifier", "text": [ "Voluntarily" ], "offsets": [ [ 1032, 1043 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03472508_inc_R1", "type": "Has_value", "arg1_id": "NCT03472508_inc_T2", "arg2_id": "NCT03472508_inc_T1", "normalized": [] }, { "id": "NCT03472508_inc_R2", "type": "Has_scope", "arg1_id": "NCT03472508_inc_T5", "arg2_id": "NCT03472508_inc_T6", "normalized": [] }, { "id": "NCT03472508_inc_R3", "type": "Has_negation", "arg1_id": "NCT03472508_inc_T8", "arg2_id": "NCT03472508_inc_T9", "normalized": [] }, { "id": "NCT03472508_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03472508_inc_T8", "arg2_id": "NCT03472508_inc_T10", "normalized": [] }, { "id": "NCT03472508_inc_R5", "type": "Has_value", "arg1_id": "NCT03472508_inc_T13", "arg2_id": "NCT03472508_inc_T14", "normalized": [] }, { "id": "NCT03472508_inc_R6", "type": "Has_value", "arg1_id": "NCT03472508_inc_T15", "arg2_id": "NCT03472508_inc_T16", "normalized": [] }, { "id": "NCT03472508_inc_R7", "type": "Has_scope", "arg1_id": "NCT03472508_inc_T12", "arg2_id": "NCT03472508_inc_T17", "normalized": [] }, { "id": "NCT03472508_inc_R8", "type": "Has_multiplier", "arg1_id": "NCT03472508_inc_T12", "arg2_id": "NCT03472508_inc_T11", "normalized": [] }, { "id": "NCT03472508_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03472508_inc_T7", "arg2_id": "NCT03472508_inc_T18", "normalized": [] }, { "id": "NCT03472508_inc_R10", "type": "Subsumes", "arg1_id": "NCT03472508_inc_T5", "arg2_id": "NCT03472508_inc_T20", "normalized": [] }, { "id": "NCT03472508_inc_R12", "type": "Has_scope", "arg1_id": "NCT03472508_inc_T19", "arg2_id": "NCT03472508_inc_T21", "normalized": [] }, { "id": "NCT03472508_inc_R11", "type": "Has_qualifier", "arg1_id": "NCT03472508_inc_T27", "arg2_id": "NCT03472508_inc_T26", "normalized": [] }, { "id": "NCT03472508_inc_R13", "type": "Has_temporal", "arg1_id": "NCT03472508_inc_T27", "arg2_id": "NCT03472508_inc_T28", "normalized": [] }, { "id": "NCT03472508_inc_R14", "type": "Has_index", "arg1_id": "NCT03472508_inc_T28", "arg2_id": "NCT03472508_inc_T29", "normalized": [] }, { "id": "NCT03472508_inc_R16", "type": "Has_mood", "arg1_id": "NCT03472508_inc_T27", "arg2_id": "NCT03472508_inc_T30", "normalized": [] }, { "id": "NCT03472508_inc_R17", "type": "Has_qualifier", "arg1_id": "NCT03472508_inc_T34", "arg2_id": "NCT03472508_inc_T35", "normalized": [] }, { "id": "NCT03472508_inc_R18", "type": "Has_qualifier", "arg1_id": "NCT03472508_inc_T33", "arg2_id": "NCT03472508_inc_T36", "normalized": [] }, { "id": "NCT03472508_inc_R20", "type": "Has_value", "arg1_id": "NCT03472508_inc_T39", "arg2_id": "NCT03472508_inc_T40", "normalized": [] }, { "id": "NCT03472508_inc_R21", "type": "Subsumes", "arg1_id": "NCT03472508_inc_T40", "arg2_id": "NCT03472508_inc_T41", "normalized": [] }, { "id": "NCT03472508_inc_R24", "type": "Has_temporal", "arg1_id": "NCT03472508_inc_T47", "arg2_id": "NCT03472508_inc_T42", "normalized": [] }, { "id": "NCT03472508_inc_R25", "type": "Has_temporal", "arg1_id": "NCT03472508_inc_T47", "arg2_id": "NCT03472508_inc_T46", "normalized": [] }, { "id": "NCT03472508_inc_R26", "type": "Has_qualifier", "arg1_id": "NCT03472508_inc_T49", "arg2_id": "NCT03472508_inc_T50", "normalized": [] } ]

[ { "id": "NCT03472846_exc_text", "type": "exclusion", "text": [ "Diabetes mellitus type 1\nrenal insufficiency III-V °\nCirrhosis hepatis (Child B or higher)\nChronic alcohol abuse\nrheumatic disease (RA, SpA, SLE)\nMalignancies (<5 years)\nEating Disorder (anorexia nervosa, bulimia)\nbone-specific pretreatment (DMAB, TPTD, strontium ranelate, SERMs) Bisphosphonate treatment is allowed\n" ], "offsets": [ [ 0, 317 ] ] } ]

[ { "id": "NCT03472846_exc_T1", "type": "Condition", "text": [ "Diabetes mellitus type 1" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T2", "type": "Condition", "text": [ "renal insufficiency" ], "offsets": [ [ 25, 44 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T3", "type": "Qualifier", "text": [ "III-V °" ], "offsets": [ [ 45, 52 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T4", "type": "Condition", "text": [ "Cirrhosis hepatis" ], "offsets": [ [ 53, 70 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T5", "type": "Measurement", "text": [ "Child" ], "offsets": [ [ 72, 77 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T6", "type": "Value", "text": [ "B or higher" ], "offsets": [ [ 78, 89 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T7", "type": "Qualifier", "text": [ "Child B or higher" ], "offsets": [ [ 72, 89 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T8", "type": "Multiplier", "text": [ "Chronic" ], "offsets": [ [ 91, 98 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T9", "type": "Condition", "text": [ "alcohol abuse" ], "offsets": [ [ 99, 112 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T10", "type": "Condition", "text": [ "rheumatic disease" ], "offsets": [ [ 113, 130 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T11", "type": "Condition", "text": [ "RA" ], "offsets": [ [ 132, 134 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T12", "type": "Condition", "text": [ "SpA" ], "offsets": [ [ 136, 139 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T13", "type": "Condition", "text": [ "SLE" ], "offsets": [ [ 141, 144 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T14", "type": "Scope", "text": [ "RA, SpA, SLE" ], "offsets": [ [ 132, 144 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T15", "type": "Condition", "text": [ "Malignancies" ], "offsets": [ [ 146, 158 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T16", "type": "Temporal", "text": [ "<5 years" ], "offsets": [ [ 160, 168 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T17", "type": "Condition", "text": [ "Eating Disorder" ], "offsets": [ [ 170, 185 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T18", "type": "Condition", "text": [ "anorexia nervosa" ], "offsets": [ [ 187, 203 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T19", "type": "Condition", "text": [ "bulimia" ], "offsets": [ [ 205, 212 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T20", "type": "Scope", "text": [ "anorexia nervosa, bulimia" ], "offsets": [ [ 187, 212 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T21", "type": "Procedure", "text": [ "bone-specific pretreatment" ], "offsets": [ [ 214, 240 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T22", "type": "Drug", "text": [ "DMAB" ], "offsets": [ [ 242, 246 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T23", "type": "Drug", "text": [ "TPTD" ], "offsets": [ [ 248, 252 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T24", "type": "Drug", "text": [ "SERMs" ], "offsets": [ [ 274, 279 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T25", "type": "Drug", "text": [ "strontium ranelate" ], "offsets": [ [ 254, 272 ] ], "normalized": [] }, { "id": "NCT03472846_exc_T27", "type": "Scope", "text": [ "DMAB, TPTD, strontium ranelate, SERMs" ], "offsets": [ [ 242, 279 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03472846_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03472846_exc_T2", "arg2_id": "NCT03472846_exc_T3", "normalized": [] }, { "id": "NCT03472846_exc_R2", "type": "Has_value", "arg1_id": "NCT03472846_exc_T5", "arg2_id": "NCT03472846_exc_T6", "normalized": [] }, { "id": "NCT03472846_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03472846_exc_T4", "arg2_id": "NCT03472846_exc_T7", "normalized": [] }, { "id": "NCT03472846_exc_R5", "type": "Has_multiplier", "arg1_id": "NCT03472846_exc_T9", "arg2_id": "NCT03472846_exc_T8", "normalized": [] }, { "id": "NCT03472846_exc_R6", "type": "Subsumes", "arg1_id": "NCT03472846_exc_T10", "arg2_id": "NCT03472846_exc_T14", "normalized": [] }, { "id": "NCT03472846_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03472846_exc_T15", "arg2_id": "NCT03472846_exc_T16", "normalized": [] }, { "id": "NCT03472846_exc_R8", "type": "Subsumes", "arg1_id": "NCT03472846_exc_T17", "arg2_id": "NCT03472846_exc_T20", "normalized": [] }, { "id": "NCT03472846_exc_R9", "type": "Subsumes", "arg1_id": "NCT03472846_exc_T21", "arg2_id": "NCT03472846_exc_T27", "normalized": [] } ]

[ { "id": "NCT03472846_inc_text", "type": "inclusion", "text": [ "Postmenopausal women\nAge 60-80 years\nT-score according to DXA: <-2.5\nindication for osteoporosis therapy according to international guidelines\n" ], "offsets": [ [ 0, 143 ] ] } ]

[ { "id": "NCT03472846_inc_T1", "type": "Condition", "text": [ "Postmenopausal" ], "offsets": [ [ 0, 14 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 15, 20 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T3", "type": "Person", "text": [ "Age" ], "offsets": [ [ 21, 24 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T4", "type": "Value", "text": [ "60-80 years" ], "offsets": [ [ 25, 36 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T5", "type": "Measurement", "text": [ "T-score" ], "offsets": [ [ 37, 44 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T6", "type": "Procedure", "text": [ "DXA" ], "offsets": [ [ 58, 61 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T7", "type": "Qualifier", "text": [ "according to DXA" ], "offsets": [ [ 45, 61 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T8", "type": "Value", "text": [ "<-2.5" ], "offsets": [ [ 63, 68 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T9", "type": "Mood", "text": [ "indication for" ], "offsets": [ [ 69, 83 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T10", "type": "Procedure", "text": [ "osteoporosis therapy" ], "offsets": [ [ 84, 104 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T11", "type": "Condition", "text": [ "osteoporosis" ], "offsets": [ [ 84, 96 ] ], "normalized": [] }, { "id": "NCT03472846_inc_T12", "type": "Qualifier", "text": [ "international guidelines" ], "offsets": [ [ 118, 142 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03472846_inc_R1", "type": "Has_value", "arg1_id": "NCT03472846_inc_T3", "arg2_id": "NCT03472846_inc_T4", "normalized": [] }, { "id": "NCT03472846_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03472846_inc_T5", "arg2_id": "NCT03472846_inc_T7", "normalized": [] }, { "id": "NCT03472846_inc_R4", "type": "Has_value", "arg1_id": "NCT03472846_inc_T5", "arg2_id": "NCT03472846_inc_T8", "normalized": [] }, { "id": "NCT03472846_inc_R6", "type": "Has_mood", "arg1_id": "NCT03472846_inc_T10", "arg2_id": "NCT03472846_inc_T9", "normalized": [] }, { "id": "NCT03472846_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT03472846_inc_T9", "arg2_id": "NCT03472846_inc_T12", "normalized": [] } ]

[ { "id": "NCT03473132_exc_text", "type": "exclusion", "text": [ "recent thrombotic event\n" ], "offsets": [ [ 0, 24 ] ] } ]

[ { "id": "NCT03473132_exc_T1", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03473132_exc_T2", "type": "Condition", "text": [ "thrombotic event" ], "offsets": [ [ 7, 23 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03473132_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03473132_exc_T2", "arg2_id": "NCT03473132_exc_T1", "normalized": [] } ]

[ { "id": "NCT03473132_inc_text", "type": "inclusion", "text": [ "LVAD on warfarin requiring temporary interruption of anticoagulation for procedures\n" ], "offsets": [ [ 0, 84 ] ] } ]

[ { "id": "NCT03473132_inc_T1", "type": "Condition", "text": [ "LVAD" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03473132_inc_T2", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 8, 16 ] ], "normalized": [] }, { "id": "NCT03473132_inc_T4", "type": "Qualifier", "text": [ "requiring temporary interruption of anticoagulation for procedures" ], "offsets": [ [ 17, 83 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03473132_inc_R1", "type": "AND", "arg1_id": "NCT03473132_inc_T1", "arg2_id": "NCT03473132_inc_T2", "normalized": [] }, { "id": "NCT03473132_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03473132_inc_T2", "arg2_id": "NCT03473132_inc_T4", "normalized": [] } ]

[ { "id": "NCT03475589_exc_text", "type": "exclusion", "text": [ "Confirmed allergy to apatinin and or its excipients;\nHypertension (high blood pressure) that can not be controlled by drugs;\nA history of active hemorragge, ulcer, intestinal perforation, intestinal obstruction, or major surgery no older than 30 days;\nNYHA III-IV heart function, or severe hepatic or renal insufficiency (Grade 4);\nPresence of multiple factors that affect oral medications, such as difficulty swallowing, nausea, vomiting, chronic diarrhea and intestinal obstruction;\nPregnant or lactating women, or women of child-bearing potential who have planned a pregnancy, or male and female patients who do not agree to practice adequate contraception during this study;\nPatients who have a history of psychotropics abuse and can not quit, or who have mental disorders;\nParticipation in other drug clinical trial within the last 4 weeks;\nPrior therapy with VEGFR inhibitors such as sorafenib and sunitinib;\nPresence of comorbidities that seriously affect the patient's safety or ability to complete the study, in the investigator's judgment;\nPatients who can not tolerate apatinib treatment as judged by the investigator depending on the their medical history;\nPatients that are considered ineligible for this study by the investigator.\n" ], "offsets": [ [ 0, 1245 ] ] } ]

[ { "id": "NCT03475589_exc_T1", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 10, 17 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T2", "type": "Drug", "text": [ "apatinin" ], "offsets": [ [ 21, 29 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T3", "type": "Drug", "text": [ "excipients" ], "offsets": [ [ 41, 51 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T4", "type": "Scope", "text": [ "apatinin and or its excipients" ], "offsets": [ [ 21, 51 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T5", "type": "Condition", "text": [ "Hypertension" ], "offsets": [ [ 53, 65 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T6", "type": "Condition", "text": [ "high blood pressure" ], "offsets": [ [ 67, 86 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T7", "type": "Qualifier", "text": [ "controlled by drugs" ], "offsets": [ [ 104, 123 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T8", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 118, 123 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T9", "type": "Negation", "text": [ "not" ], "offsets": [ [ 97, 100 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T10", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 138, 144 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T11", "type": "Condition", "text": [ "hemorragge" ], "offsets": [ [ 145, 155 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T12", "type": "Condition", "text": [ "ulcer" ], "offsets": [ [ 157, 162 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T13", "type": "Condition", "text": [ "intestinal perforation" ], "offsets": [ [ 164, 186 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T14", "type": "Condition", "text": [ "intestinal obstruction" ], "offsets": [ [ 188, 210 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T15", "type": "Condition", "text": [ "major surgery" ], "offsets": [ [ 215, 228 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T16", "type": "Temporal", "text": [ "no older than 30 days" ], "offsets": [ [ 229, 250 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T17", "type": "Scope", "text": [ "active hemorragge, ulcer, intestinal perforation, intestinal obstruction, or major surgery" ], "offsets": [ [ 138, 228 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T18", "type": "Measurement", "text": [ "NYHA" ], "offsets": [ [ 252, 256 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T19", "type": "Value", "text": [ "III-IV" ], "offsets": [ [ 257, 263 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T20", "type": "Condition", "text": [ "heart function" ], "offsets": [ [ 264, 278 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T21", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 283, 289 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T22", "type": "Condition", "text": [ "atic or", "ufficiency (G" ], "offsets": [ [ 293, 300 ], [ 310, 323 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T23", "type": "Condition", "text": [ "renal insufficiency" ], "offsets": [ [ 301, 320 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T24", "type": "Qualifier", "text": [ "Grade 4" ], "offsets": [ [ 322, 329 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T25", "type": "Scope", "text": [ "hepatic or renal insufficiency" ], "offsets": [ [ 290, 320 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T26", "type": "Observation", "text": [ "factors that affect oral medications" ], "offsets": [ [ 353, 389 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T27", "type": "Condition", "text": [ "difficulty swallowing" ], "offsets": [ [ 399, 420 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T28", "type": "Condition", "text": [ "nausea" ], "offsets": [ [ 422, 428 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T29", "type": "Condition", "text": [ "vomiting" ], "offsets": [ [ 430, 438 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T30", "type": "Condition", "text": [ "chronic diarrhea" ], "offsets": [ [ 440, 456 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T31", "type": "Condition", "text": [ "intestinal obstruction" ], "offsets": [ [ 461, 483 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T32", "type": "Scope", "text": [ "difficulty swallowing, nausea, vomiting, chronic diarrhea and intestinal obstruction" ], "offsets": [ [ 399, 483 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T34", "type": "Observation", "text": [ "history" ], "offsets": [ [ 699, 706 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T35", "type": "Condition", "text": [ "abuse" ], "offsets": [ [ 724, 729 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T36", "type": "Drug", "text": [ "psychotropics" ], "offsets": [ [ 710, 723 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T37", "type": "Condition", "text": [ "mental disorders" ], "offsets": [ [ 760, 776 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T40", "type": "Drug", "text": [ "VEGFR inhibitors" ], "offsets": [ [ 865, 881 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T41", "type": "Drug", "text": [ "sorafenib" ], "offsets": [ [ 890, 899 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T42", "type": "Drug", "text": [ "sunitinib" ], "offsets": [ [ 904, 913 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T43", "type": "Scope", "text": [ "sorafenib and sunitinib" ], "offsets": [ [ 890, 913 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T45", "type": "Condition", "text": [ "tolerate" ], "offsets": [ [ 1071, 1079 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T46", "type": "Negation", "text": [ "not" ], "offsets": [ [ 1067, 1070 ] ], "normalized": [] }, { "id": "NCT03475589_exc_T47", "type": "Drug", "text": [ "apatinib" ], "offsets": [ [ 1080, 1088 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03475589_exc_R1", "type": "Has_scope", "arg1_id": "NCT03475589_exc_T1", "arg2_id": "NCT03475589_exc_T4", "normalized": [] }, { "id": "NCT03475589_exc_R2", "type": "Subsumes", "arg1_id": "NCT03475589_exc_T5", "arg2_id": "NCT03475589_exc_T6", "normalized": [] }, { "id": "NCT03475589_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03475589_exc_T5", "arg2_id": "NCT03475589_exc_T7", "normalized": [] }, { "id": "NCT03475589_exc_R5", "type": "Has_negation", "arg1_id": "NCT03475589_exc_T7", "arg2_id": "NCT03475589_exc_T9", "normalized": [] }, { "id": "NCT03475589_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03475589_exc_T11", "arg2_id": "NCT03475589_exc_T10", "normalized": [] }, { "id": "NCT03475589_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03475589_exc_T17", "arg2_id": "NCT03475589_exc_T16", "normalized": [] }, { "id": "NCT03475589_exc_R8", "type": "Has_value", "arg1_id": "NCT03475589_exc_T18", "arg2_id": "NCT03475589_exc_T19", "normalized": [] }, { "id": "NCT03475589_exc_R9", "type": "Subsumes", "arg1_id": "NCT03475589_exc_T21", "arg2_id": "NCT03475589_exc_T24", "normalized": [] }, { "id": "NCT03475589_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03475589_exc_T25", "arg2_id": "NCT03475589_exc_T21", "normalized": [] }, { "id": "NCT03475589_exc_R11", "type": "AND", "arg1_id": "NCT03475589_exc_T20", "arg2_id": "NCT03475589_exc_T18", "normalized": [] }, { "id": "NCT03475589_exc_R13", "type": "AND", "arg1_id": "NCT03475589_exc_T35", "arg2_id": "NCT03475589_exc_T36", "normalized": [] }, { "id": "NCT03475589_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03475589_exc_T35", "arg2_id": "NCT03475589_exc_T34", "normalized": [] }, { "id": "NCT03475589_exc_R15", "type": "Has_scope", "arg1_id": "NCT03475589_exc_T40", "arg2_id": "NCT03475589_exc_T43", "normalized": [] }, { "id": "NCT03475589_exc_R16", "type": "Has_negation", "arg1_id": "NCT03475589_exc_T45", "arg2_id": "NCT03475589_exc_T46", "normalized": [] }, { "id": "NCT03475589_exc_R17", "type": "AND", "arg1_id": "NCT03475589_exc_T45", "arg2_id": "NCT03475589_exc_T47", "normalized": [] } ]

[ { "id": "NCT03475589_inc_text", "type": "inclusion", "text": [ "Age of 18 and over, male or female;\nPatients with histologically confirmed advanced (stage IV) gastric cancer, NSCLC, breast cancer or ovarian cancer, who choose monotherapy of oral vascular targeting drug (apatinib) due to intolerability or inappropriateness of other therapies;\nPresence of measurable lesions (=10mm on spiral CT scan) subject to RECIST 1.1;\nBlood pressured controlled at 150/100 mHg following drug administration;\nAn ECOG PS score of between 0 and 1;\nA life expectancy of at least 3 months;\nSubjects who volunteer to participate in this study and have signed the Informed Consent Form (ICF), with good compliance with treatment and follow-up.\n" ], "offsets": [ [ 0, 662 ] ] } ]

[ { "id": "NCT03475589_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T2", "type": "Value", "text": [ "18 and over" ], "offsets": [ [ 7, 18 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T3", "type": "Person", "text": [ "male" ], "offsets": [ [ 20, 24 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T4", "type": "Person", "text": [ "female" ], "offsets": [ [ 28, 34 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T5", "type": "Qualifier", "text": [ "histologically confirmed" ], "offsets": [ [ 50, 74 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T6", "type": "Procedure", "text": [ "histologically" ], "offsets": [ [ 50, 64 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T7", "type": "Qualifier", "text": [ "advanced" ], "offsets": [ [ 75, 83 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T8", "type": "Qualifier", "text": [ "stage IV" ], "offsets": [ [ 85, 93 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T9", "type": "Condition", "text": [ "gastric cancer" ], "offsets": [ [ 95, 109 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T10", "type": "Condition", "text": [ "NSCLC" ], "offsets": [ [ 111, 116 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T11", "type": "Condition", "text": [ "breast cancer" ], "offsets": [ [ 118, 131 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T12", "type": "Condition", "text": [ "ovarian cancer" ], "offsets": [ [ 135, 149 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T13", "type": "Procedure", "text": [ "monotherapy" ], "offsets": [ [ 162, 173 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T14", "type": "Drug", "text": [ "oral vascular targeting drug" ], "offsets": [ [ 177, 205 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T15", "type": "Drug", "text": [ "apatinib" ], "offsets": [ [ 207, 215 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T17", "type": "Scope", "text": [ "gastric cancer, NSCLC, breast cancer or ovarian cancer" ], "offsets": [ [ 95, 149 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T18", "type": "Condition", "text": [ "measurable lesions" ], "offsets": [ [ 292, 310 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T19", "type": "Value", "text": [ "=10mm" ], "offsets": [ [ 312, 317 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T20", "type": "Procedure", "text": [ "spiral CT scan" ], "offsets": [ [ 321, 335 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T21", "type": "Qualifier", "text": [ "RECIST 1.1" ], "offsets": [ [ 348, 358 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T22", "type": "Measurement", "text": [ "Blood pressured" ], "offsets": [ [ 360, 375 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T23", "type": "Qualifier", "text": [ "controlled" ], "offsets": [ [ 376, 386 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T24", "type": "Value", "text": [ "150/100 mHg" ], "offsets": [ [ 390, 401 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T25", "type": "Measurement", "text": [ "ECOG PS" ], "offsets": [ [ 436, 443 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T26", "type": "Value", "text": [ "between 0 and 1" ], "offsets": [ [ 453, 468 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T27", "type": "Observation", "text": [ "life expectancy" ], "offsets": [ [ 472, 487 ] ], "normalized": [] }, { "id": "NCT03475589_inc_T28", "type": "Value", "text": [ "at least 3 months" ], "offsets": [ [ 491, 508 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03475589_inc_R1", "type": "Has_value", "arg1_id": "NCT03475589_inc_T1", "arg2_id": "NCT03475589_inc_T2", "normalized": [] }, { "id": "NCT03475589_inc_R2", "type": "Subsumes", "arg1_id": "NCT03475589_inc_T7", "arg2_id": "NCT03475589_inc_T8", "normalized": [] }, { "id": "NCT03475589_inc_R4", "type": "Subsumes", "arg1_id": "NCT03475589_inc_T14", "arg2_id": "NCT03475589_inc_T15", "normalized": [] }, { "id": "NCT03475589_inc_R5", "type": "AND", "arg1_id": "NCT03475589_inc_T13", "arg2_id": "NCT03475589_inc_T14", "normalized": [] }, { "id": "NCT03475589_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03475589_inc_T17", "arg2_id": "NCT03475589_inc_T7", "normalized": [] }, { "id": "NCT03475589_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT03475589_inc_T17", "arg2_id": "NCT03475589_inc_T5", "normalized": [] }, { "id": "NCT03475589_inc_R8", "type": "Has_value", "arg1_id": "NCT03475589_inc_T20", "arg2_id": "NCT03475589_inc_T19", "normalized": [] }, { "id": "NCT03475589_inc_R9", "type": "AND", "arg1_id": "NCT03475589_inc_T18", "arg2_id": "NCT03475589_inc_T20", "normalized": [] }, { "id": "NCT03475589_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT03475589_inc_T18", "arg2_id": "NCT03475589_inc_T21", "normalized": [] }, { "id": "NCT03475589_inc_R11", "type": "Has_value", "arg1_id": "NCT03475589_inc_T22", "arg2_id": "NCT03475589_inc_T24", "normalized": [] }, { "id": "NCT03475589_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03475589_inc_T22", "arg2_id": "NCT03475589_inc_T23", "normalized": [] }, { "id": "NCT03475589_inc_R13", "type": "Has_value", "arg1_id": "NCT03475589_inc_T25", "arg2_id": "NCT03475589_inc_T26", "normalized": [] }, { "id": "NCT03475589_inc_R14", "type": "Has_value", "arg1_id": "NCT03475589_inc_T27", "arg2_id": "NCT03475589_inc_T28", "normalized": [] } ]

[ { "id": "NCT03476850_exc_text", "type": "exclusion", "text": [ "Chronic pain or narcotic usage during the preceding 30 days\nInfection at or near the intended needle insertion site\nComplex or altered abdominal wall anatomy\nWeight <45kg\n" ], "offsets": [ [ 0, 171 ] ] } ]

[ { "id": "NCT03476850_exc_T1", "type": "Condition", "text": [ "Chronic pain" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T2", "type": "Drug", "text": [ "narcotic" ], "offsets": [ [ 16, 24 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T3", "type": "Temporal", "text": [ "during the preceding 30 days" ], "offsets": [ [ 31, 59 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T4", "type": "Scope", "text": [ "Chronic pain or narcotic" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T5", "type": "Condition", "text": [ "Infection" ], "offsets": [ [ 60, 69 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T6", "type": "Qualifier", "text": [ "intended needle insertion site" ], "offsets": [ [ 85, 115 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T7", "type": "Condition", "text": [ "altered abdominal wall anatomy" ], "offsets": [ [ 127, 157 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T8", "type": "Condition", "text": [ "mplex o", "dominal wall anatomy\nW" ], "offsets": [ [ 118, 125 ], [ 137, 159 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T9", "type": "Measurement", "text": [ "Weight" ], "offsets": [ [ 158, 164 ] ], "normalized": [] }, { "id": "NCT03476850_exc_T10", "type": "Value", "text": [ "<45kg" ], "offsets": [ [ 165, 170 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03476850_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03476850_exc_T4", "arg2_id": "NCT03476850_exc_T3", "normalized": [] }, { "id": "NCT03476850_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03476850_exc_T5", "arg2_id": "NCT03476850_exc_T6", "normalized": [] }, { "id": "NCT03476850_exc_R3", "type": "Has_value", "arg1_id": "NCT03476850_exc_T9", "arg2_id": "NCT03476850_exc_T10", "normalized": [] } ]

[ { "id": "NCT03476850_inc_text", "type": "inclusion", "text": [ "Patients undergoing laparoscopic assisted donor nephrectomy\nPatients that have elected to have a nerve block\n18 years of age or older\nPatients of ASA status I - III\n" ], "offsets": [ [ 0, 165 ] ] } ]

[ { "id": "NCT03476850_inc_T1", "type": "Procedure", "text": [ "laparoscopic assisted donor nephrectomy" ], "offsets": [ [ 20, 59 ] ], "normalized": [] }, { "id": "NCT03476850_inc_T2", "type": "Procedure", "text": [ "nerve block" ], "offsets": [ [ 97, 108 ] ], "normalized": [] }, { "id": "NCT03476850_inc_T3", "type": "Mood", "text": [ "elected to have" ], "offsets": [ [ 79, 94 ] ], "normalized": [] }, { "id": "NCT03476850_inc_T4", "type": "Value", "text": [ " years ", " older\n" ], "offsets": [ [ 111, 118 ], [ 127, 134 ] ], "normalized": [] }, { "id": "NCT03476850_inc_T5", "type": "Person", "text": [ "age" ], "offsets": [ [ 121, 124 ] ], "normalized": [] }, { "id": "NCT03476850_inc_T6", "type": "Measurement", "text": [ "ASA status" ], "offsets": [ [ 146, 156 ] ], "normalized": [] }, { "id": "NCT03476850_inc_T7", "type": "Value", "text": [ "I - III" ], "offsets": [ [ 157, 164 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03476850_inc_R1", "type": "Has_mood", "arg1_id": "NCT03476850_inc_T2", "arg2_id": "NCT03476850_inc_T3", "normalized": [] }, { "id": "NCT03476850_inc_R2", "type": "Has_value", "arg1_id": "NCT03476850_inc_T5", "arg2_id": "NCT03476850_inc_T4", "normalized": [] }, { "id": "NCT03476850_inc_R3", "type": "Has_value", "arg1_id": "NCT03476850_inc_T6", "arg2_id": "NCT03476850_inc_T7", "normalized": [] } ]

[ { "id": "NCT03477851_exc_text", "type": "exclusion", "text": [ "No consent\nSpinal anesthesia or sciatic nerve block contraindicated\nKnown intolerance to tramadol or other contraindications for the drug\n" ], "offsets": [ [ 0, 138 ] ] } ]

[ { "id": "NCT03477851_exc_T1", "type": "Observation", "text": [ "consent" ], "offsets": [ [ 3, 10 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T2", "type": "Negation", "text": [ "No" ], "offsets": [ [ 0, 2 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T4", "type": "Procedure", "text": [ "Spinal anesthesia" ], "offsets": [ [ 11, 28 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T5", "type": "Procedure", "text": [ "sciatic nerve block" ], "offsets": [ [ 32, 51 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T6", "type": "Condition", "text": [ "contraindicated" ], "offsets": [ [ 52, 67 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T7", "type": "Scope", "text": [ "Spinal anesthesia or sciatic nerve block" ], "offsets": [ [ 11, 51 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T8", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 74, 85 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T9", "type": "Drug", "text": [ "tramadol" ], "offsets": [ [ 89, 97 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T10", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 107, 124 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T11", "type": "Drug", "text": [ "the drug" ], "offsets": [ [ 129, 137 ] ], "normalized": [] }, { "id": "NCT03477851_exc_T12", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 101, 106 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03477851_exc_R1", "type": "Has_negation", "arg1_id": "NCT03477851_exc_T1", "arg2_id": "NCT03477851_exc_T2", "normalized": [] }, { "id": "NCT03477851_exc_R2", "type": "Has_scope", "arg1_id": "NCT03477851_exc_T6", "arg2_id": "NCT03477851_exc_T7", "normalized": [] }, { "id": "NCT03477851_exc_R3", "type": "AND", "arg1_id": "NCT03477851_exc_T10", "arg2_id": "NCT03477851_exc_T11", "normalized": [] }, { "id": "NCT03477851_exc_R4", "type": "AND", "arg1_id": "NCT03477851_exc_T8", "arg2_id": "NCT03477851_exc_T9", "normalized": [] }, { "id": "NCT03477851_exc_R5", "type": "AND", "arg1_id": "NCT03477851_exc_T8", "arg2_id": "NCT03477851_exc_T10", "normalized": [] }, { "id": "NCT03477851_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03477851_exc_T10", "arg2_id": "NCT03477851_exc_T12", "normalized": [] } ]

[ { "id": "NCT03477851_inc_text", "type": "inclusion", "text": [ "Patients with foot fracture scheduled for surgical repair in spinal anesthesia\nInformed consent\n" ], "offsets": [ [ 0, 96 ] ] } ]

[ { "id": "NCT03477851_inc_T1", "type": "Condition", "text": [ "foot fracture" ], "offsets": [ [ 14, 27 ] ], "normalized": [] }, { "id": "NCT03477851_inc_T2", "type": "Mood", "text": [ "scheduled for" ], "offsets": [ [ 28, 41 ] ], "normalized": [] }, { "id": "NCT03477851_inc_T3", "type": "Procedure", "text": [ "surgical repair" ], "offsets": [ [ 42, 57 ] ], "normalized": [] }, { "id": "NCT03477851_inc_T4", "type": "Procedure", "text": [ "spinal anesthesia" ], "offsets": [ [ 61, 78 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03477851_inc_R1", "type": "AND", "arg1_id": "NCT03477851_inc_T3", "arg2_id": "NCT03477851_inc_T4", "normalized": [] }, { "id": "NCT03477851_inc_R2", "type": "Has_mood", "arg1_id": "NCT03477851_inc_T3", "arg2_id": "NCT03477851_inc_T2", "normalized": [] } ]

[ { "id": "NCT03479502_exc_text", "type": "exclusion", "text": [ "allergy to Doxycycline or Methylprednisolone,\npregnancy,\ndiagnosis,\nInflammatory arthritis or diabetes,\nsecondary adhesive capsulitis (history of significant trauma, rotator cuff tear injury, stroke)\nevidence of arthritis on x-ray,\ncurrent infectious disease, and\nany previous treatment for the for adhesive capsulitis of the affected shoulder.\n" ], "offsets": [ [ 0, 345 ] ] } ]

[ { "id": "NCT03479502_exc_T1", "type": "Drug", "text": [ "Doxycycline" ], "offsets": [ [ 11, 22 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T2", "type": "Drug", "text": [ "Methylprednisolone" ], "offsets": [ [ 26, 44 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T3", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T4", "type": "Scope", "text": [ "Doxycycline or Methylprednisolone" ], "offsets": [ [ 11, 44 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T5", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 46, 55 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T6", "type": "Condition", "text": [ "diagnosis" ], "offsets": [ [ 57, 66 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T7", "type": "Condition", "text": [ "Inflammatory arthritis" ], "offsets": [ [ 68, 90 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T8", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 94, 102 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T9", "type": "Qualifier", "text": [ "secondary" ], "offsets": [ [ 104, 113 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T10", "type": "Condition", "text": [ "adhesive capsulitis" ], "offsets": [ [ 114, 133 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T11", "type": "Observation", "text": [ "history" ], "offsets": [ [ 135, 142 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T12", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 146, 157 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T13", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 158, 164 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T14", "type": "Condition", "text": [ "rotator cuff tear injury" ], "offsets": [ [ 166, 190 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T15", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 192, 198 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T16", "type": "Scope", "text": [ "significant trauma, rotator cuff tear injury, stroke" ], "offsets": [ [ 146, 198 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T17", "type": "Scope", "text": [ "history of significant trauma, rotator cuff tear injury, stroke" ], "offsets": [ [ 135, 198 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T18", "type": "Mood", "text": [ "evidence of" ], "offsets": [ [ 200, 211 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T19", "type": "Condition", "text": [ "arthritis" ], "offsets": [ [ 212, 221 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T20", "type": "Procedure", "text": [ "x-ray" ], "offsets": [ [ 225, 230 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T21", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 232, 239 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T22", "type": "Condition", "text": [ "infectious disease" ], "offsets": [ [ 240, 258 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T23", "type": "Qualifier", "text": [ "any" ], "offsets": [ [ 264, 267 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T24", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 268, 276 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T25", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 277, 286 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T26", "type": "Condition", "text": [ "adhesive capsulitis" ], "offsets": [ [ 299, 318 ] ], "normalized": [] }, { "id": "NCT03479502_exc_T27", "type": "Qualifier", "text": [ "affected shoulder" ], "offsets": [ [ 326, 343 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03479502_exc_R1", "type": "Has_scope", "arg1_id": "NCT03479502_exc_T3", "arg2_id": "NCT03479502_exc_T4", "normalized": [] }, { "id": "NCT03479502_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03479502_exc_T13", "arg2_id": "NCT03479502_exc_T12", "normalized": [] }, { "id": "NCT03479502_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03479502_exc_T16", "arg2_id": "NCT03479502_exc_T11", "normalized": [] }, { "id": "NCT03479502_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03479502_exc_T10", "arg2_id": "NCT03479502_exc_T9", "normalized": [] }, { "id": "NCT03479502_exc_R5", "type": "Subsumes", "arg1_id": "NCT03479502_exc_T10", "arg2_id": "NCT03479502_exc_T17", "normalized": [] }, { "id": "NCT03479502_exc_R6", "type": "AND", "arg1_id": "NCT03479502_exc_T20", "arg2_id": "NCT03479502_exc_T19", "normalized": [] }, { "id": "NCT03479502_exc_R7", "type": "Has_mood", "arg1_id": "NCT03479502_exc_T19", "arg2_id": "NCT03479502_exc_T18", "normalized": [] }, { "id": "NCT03479502_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03479502_exc_T22", "arg2_id": "NCT03479502_exc_T21", "normalized": [] }, { "id": "NCT03479502_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03479502_exc_T25", "arg2_id": "NCT03479502_exc_T24", "normalized": [] }, { "id": "NCT03479502_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03479502_exc_T25", "arg2_id": "NCT03479502_exc_T23", "normalized": [] }, { "id": "NCT03479502_exc_R11", "type": "AND", "arg1_id": "NCT03479502_exc_T25", "arg2_id": "NCT03479502_exc_T26", "normalized": [] }, { "id": "NCT03479502_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03479502_exc_T26", "arg2_id": "NCT03479502_exc_T27", "normalized": [] } ]

[ { "id": "NCT03479502_inc_text", "type": "inclusion", "text": [ "18 years of age and older,\ndiagnosis of stage II adhesive capsulitis as determined by clinical examination of the treating physician, and\nabsence of abnormal findings on X-ray.\n" ], "offsets": [ [ 0, 177 ] ] } ]

[ { "id": "NCT03479502_inc_T1", "type": "Value", "text": [ "18 years", "and older" ], "offsets": [ [ 0, 8 ], [ 16, 25 ] ], "normalized": [] }, { "id": "NCT03479502_inc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 12, 15 ] ], "normalized": [] }, { "id": "NCT03479502_inc_T3", "type": "Qualifier", "text": [ "stage II" ], "offsets": [ [ 40, 48 ] ], "normalized": [] }, { "id": "NCT03479502_inc_T4", "type": "Condition", "text": [ "adhesive capsulitis" ], "offsets": [ [ 49, 68 ] ], "normalized": [] }, { "id": "NCT03479502_inc_T5", "type": "Qualifier", "text": [ "as determined by clinical examination" ], "offsets": [ [ 69, 106 ] ], "normalized": [] }, { "id": "NCT03479502_inc_T6", "type": "Procedure", "text": [ "clinical examination" ], "offsets": [ [ 86, 106 ] ], "normalized": [] }, { "id": "NCT03479502_inc_T7", "type": "Negation", "text": [ "absence of" ], "offsets": [ [ 138, 148 ] ], "normalized": [] }, { "id": "NCT03479502_inc_T8", "type": "Condition", "text": [ "abnormal findings" ], "offsets": [ [ 149, 166 ] ], "normalized": [] }, { "id": "NCT03479502_inc_T9", "type": "Procedure", "text": [ "X-ray" ], "offsets": [ [ 170, 175 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03479502_inc_R1", "type": "Has_value", "arg1_id": "NCT03479502_inc_T2", "arg2_id": "NCT03479502_inc_T1", "normalized": [] }, { "id": "NCT03479502_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03479502_inc_T4", "arg2_id": "NCT03479502_inc_T3", "normalized": [] }, { "id": "NCT03479502_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03479502_inc_T4", "arg2_id": "NCT03479502_inc_T5", "normalized": [] }, { "id": "NCT03479502_inc_R5", "type": "AND", "arg1_id": "NCT03479502_inc_T9", "arg2_id": "NCT03479502_inc_T8", "normalized": [] }, { "id": "NCT03479502_inc_R6", "type": "Has_negation", "arg1_id": "NCT03479502_inc_T8", "arg2_id": "NCT03479502_inc_T7", "normalized": [] } ]

[ { "id": "NCT03480607_exc_text", "type": "exclusion", "text": [ "known allergy to any of drugs used\ncoagulopathy\nany wound or infection related to puncture site\nmajor illness\nfailure to gain consent of parents.\n" ], "offsets": [ [ 0, 146 ] ] } ]

[ { "id": "NCT03480607_exc_T1", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 6, 13 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T2", "type": "Drug", "text": [ "drugs used" ], "offsets": [ [ 24, 34 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T3", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 35, 47 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T4", "type": "Condition", "text": [ "wound" ], "offsets": [ [ 52, 57 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T5", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 61, 70 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T6", "type": "Qualifier", "text": [ "puncture site" ], "offsets": [ [ 82, 95 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T7", "type": "Scope", "text": [ "wound or infection" ], "offsets": [ [ 52, 70 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T8", "type": "Observation", "text": [ "consent of parents" ], "offsets": [ [ 126, 144 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T9", "type": "Negation", "text": [ "failure to gain" ], "offsets": [ [ 110, 125 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T11", "type": "Qualifier", "text": [ "major" ], "offsets": [ [ 96, 101 ] ], "normalized": [] }, { "id": "NCT03480607_exc_T12", "type": "Condition", "text": [ "illness" ], "offsets": [ [ 102, 109 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03480607_exc_R1", "type": "AND", "arg1_id": "NCT03480607_exc_T1", "arg2_id": "NCT03480607_exc_T2", "normalized": [] }, { "id": "NCT03480607_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03480607_exc_T7", "arg2_id": "NCT03480607_exc_T6", "normalized": [] }, { "id": "NCT03480607_exc_R3", "type": "Has_negation", "arg1_id": "NCT03480607_exc_T8", "arg2_id": "NCT03480607_exc_T9", "normalized": [] }, { "id": "NCT03480607_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03480607_exc_T12", "arg2_id": "NCT03480607_exc_T11", "normalized": [] } ]

[ { "id": "NCT03480607_inc_text", "type": "inclusion", "text": [ "American society of anesthesiologist (ASA) physical status I or II\n" ], "offsets": [ [ 0, 67 ] ] } ]

[ { "id": "NCT03480607_inc_T1", "type": "Measurement", "text": [ "American society of anesthesiologist", "physical status" ], "offsets": [ [ 0, 36 ], [ 43, 58 ] ], "normalized": [] }, { "id": "NCT03480607_inc_T2", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 38, 41 ] ], "normalized": [] }, { "id": "NCT03480607_inc_T3", "type": "Value", "text": [ "I or II" ], "offsets": [ [ 59, 66 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03480607_inc_R1", "type": "Subsumes", "arg1_id": "NCT03480607_inc_T1", "arg2_id": "NCT03480607_inc_T2", "normalized": [] }, { "id": "NCT03480607_inc_R2", "type": "Has_value", "arg1_id": "NCT03480607_inc_T1", "arg2_id": "NCT03480607_inc_T3", "normalized": [] } ]

[ { "id": "NCT03481894_exc_text", "type": "exclusion", "text": [ "Known hypersensitivity to egg, soybean proteins, peanut proteins, corn or corn products, or to any of the active substances or excipients\nSevere hyperlipidemia or severe disorders of lipid metabolism characterized by hypertriglyceridemia (serum triglyceride concentration >1,000 g/dL).\nInborn errors of amino acid metabolism\nCardiopulmonary instability (including pulmonary edema, cardiac insufficiency, myocardial infarction, acidosis and hemodynamic instability requiring significant vasopressor support)\nHemophagocytic syndrome.\nPN in the last 7 days prior to study enrollment.\nNeed for chronic PN before study start\nLiver enzymes (either AST, ALT, GGPT), or direct bilirubin exceeding 2 x upper limit of normal range\nPathologically altered level of any serum electrolyte (sodium, potassium, magnesium, calcium, chloride, phosphate) unless corrected prior to the start of study treatment\nPathologically altered blood pH, or oxygen saturation, or carbon dioxide unless corrected prior to the start of study treatment\nPregnancy or lactation\nParticipation in another clinical study\n" ], "offsets": [ [ 0, 1082 ] ] } ]

[ { "id": "NCT03481894_exc_T1", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 6, 22 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T2", "type": "Drug", "text": [ "egg" ], "offsets": [ [ 26, 29 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T3", "type": "Drug", "text": [ "soybean proteins" ], "offsets": [ [ 31, 47 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T4", "type": "Drug", "text": [ "peanut proteins" ], "offsets": [ [ 49, 64 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T5", "type": "Drug", "text": [ "corn" ], "offsets": [ [ 66, 70 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T6", "type": "Drug", "text": [ "corn products" ], "offsets": [ [ 74, 87 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T7", "type": "Drug", "text": [ "active substances" ], "offsets": [ [ 106, 123 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T8", "type": "Drug", "text": [ "excipients" ], "offsets": [ [ 127, 137 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T9", "type": "Scope", "text": [ "egg, soybean proteins, peanut proteins, corn or corn products, or to any of the active substances or excipients" ], "offsets": [ [ 26, 137 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T10", "type": "Condition", "text": [ "hyperlipidemia" ], "offsets": [ [ 145, 159 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T11", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 138, 144 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T12", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 163, 169 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T13", "type": "Condition", "text": [ "disorders of lipid metabolism" ], "offsets": [ [ 170, 199 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T14", "type": "Condition", "text": [ "hypertriglyceridemia" ], "offsets": [ [ 217, 237 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T15", "type": "Measurement", "text": [ "serum triglyceride concentration" ], "offsets": [ [ 239, 271 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T16", "type": "Value", "text": [ ">1,000 g/dL" ], "offsets": [ [ 272, 283 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T17", "type": "Condition", "text": [ "Inborn errors of amino acid metabolism" ], "offsets": [ [ 286, 324 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T18", "type": "Condition", "text": [ "Cardiopulmonary instability" ], "offsets": [ [ 325, 352 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T19", "type": "Condition", "text": [ "pulmonary edema" ], "offsets": [ [ 364, 379 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T20", "type": "Condition", "text": [ "cardiac insufficiency" ], "offsets": [ [ 381, 402 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T21", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 404, 425 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T22", "type": "Condition", "text": [ "acidosis" ], "offsets": [ [ 427, 435 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T23", "type": "Condition", "text": [ "hemodynamic instability" ], "offsets": [ [ 440, 463 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T24", "type": "Qualifier", "text": [ "vasopressor support" ], "offsets": [ [ 486, 505 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T25", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 474, 485 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T26", "type": "Drug", "text": [ "vasopressor" ], "offsets": [ [ 486, 497 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T27", "type": "Scope", "text": [ "pulmonary edema, cardiac insufficiency, myocardial infarction, acidosis and hemodynamic instability requiring significant vasopressor support" ], "offsets": [ [ 364, 505 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T28", "type": "Condition", "text": [ "Hemophagocytic syndrome" ], "offsets": [ [ 507, 530 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T29", "type": "Procedure", "text": [ "PN" ], "offsets": [ [ 532, 534 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T30", "type": "Temporal", "text": [ "in the last 7 days prior to study enrollment" ], "offsets": [ [ 535, 579 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T31", "type": "Reference_point", "text": [ "study enrollment" ], "offsets": [ [ 563, 579 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T32", "type": "Procedure", "text": [ "chronic PN" ], "offsets": [ [ 590, 600 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T33", "type": "Temporal", "text": [ "before study start" ], "offsets": [ [ 601, 619 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T34", "type": "Reference_point", "text": [ "study start" ], "offsets": [ [ 608, 619 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T35", "type": "Measurement", "text": [ "Liver enzymes" ], "offsets": [ [ 620, 633 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T36", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 642, 645 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T37", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 647, 650 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T38", "type": "Measurement", "text": [ "GGPT" ], "offsets": [ [ 652, 656 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T39", "type": "Measurement", "text": [ "direct bilirubin" ], "offsets": [ [ 662, 678 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T40", "type": "Value", "text": [ "exceeding 2 x upper limit of normal range" ], "offsets": [ [ 679, 720 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T41", "type": "Scope", "text": [ "AST, ALT, GGPT" ], "offsets": [ [ 642, 656 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T42", "type": "Scope", "text": [ "Liver enzymes (either AST, ALT, GGPT), or direct bilirubin" ], "offsets": [ [ 620, 678 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T43", "type": "Value", "text": [ "Pathologically altered" ], "offsets": [ [ 721, 743 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T44", "type": "Measurement", "text": [ "level of any serum electrolyte" ], "offsets": [ [ 744, 774 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T45", "type": "Measurement", "text": [ "sodium" ], "offsets": [ [ 776, 782 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T46", "type": "Measurement", "text": [ "potassium" ], "offsets": [ [ 784, 793 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T47", "type": "Measurement", "text": [ "magnesium" ], "offsets": [ [ 795, 804 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T48", "type": "Measurement", "text": [ "calcium" ], "offsets": [ [ 806, 813 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T49", "type": "Measurement", "text": [ "chloride" ], "offsets": [ [ 815, 823 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T50", "type": "Measurement", "text": [ "phosphate" ], "offsets": [ [ 825, 834 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T51", "type": "Scope", "text": [ "sodium, potassium, magnesium, calcium, chloride, phosphate" ], "offsets": [ [ 776, 834 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T53", "type": "Value", "text": [ "Pathologically altered" ], "offsets": [ [ 891, 913 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T54", "type": "Measurement", "text": [ "blood pH" ], "offsets": [ [ 914, 922 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T55", "type": "Measurement", "text": [ "oxygen saturation" ], "offsets": [ [ 927, 944 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T56", "type": "Measurement", "text": [ "carbon dioxide" ], "offsets": [ [ 949, 963 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T57", "type": "Scope", "text": [ "blood pH, or oxygen saturation, or carbon dioxide" ], "offsets": [ [ 914, 963 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T58", "type": "Condition", "text": [ "lactation" ], "offsets": [ [ 1032, 1041 ] ], "normalized": [] }, { "id": "NCT03481894_exc_T59", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 1019, 1028 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03481894_exc_R1", "type": "Has_scope", "arg1_id": "NCT03481894_exc_T1", "arg2_id": "NCT03481894_exc_T9", "normalized": [] }, { "id": "NCT03481894_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03481894_exc_T10", "arg2_id": "NCT03481894_exc_T11", "normalized": [] }, { "id": "NCT03481894_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03481894_exc_T13", "arg2_id": "NCT03481894_exc_T12", "normalized": [] }, { "id": "NCT03481894_exc_R4", "type": "Has_value", "arg1_id": "NCT03481894_exc_T15", "arg2_id": "NCT03481894_exc_T16", "normalized": [] }, { "id": "NCT03481894_exc_R5", "type": "Subsumes", "arg1_id": "NCT03481894_exc_T14", "arg2_id": "NCT03481894_exc_T15", "normalized": [] }, { "id": "NCT03481894_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03481894_exc_T24", "arg2_id": "NCT03481894_exc_T25", "normalized": [] }, { "id": "NCT03481894_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03481894_exc_T23", "arg2_id": "NCT03481894_exc_T24", "normalized": [] }, { "id": "NCT03481894_exc_R8", "type": "Subsumes", "arg1_id": "NCT03481894_exc_T18", "arg2_id": "NCT03481894_exc_T27", "normalized": [] }, { "id": "NCT03481894_exc_R9", "type": "Has_index", "arg1_id": "NCT03481894_exc_T30", "arg2_id": "NCT03481894_exc_T31", "normalized": [] }, { "id": "NCT03481894_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03481894_exc_T29", "arg2_id": "NCT03481894_exc_T30", "normalized": [] }, { "id": "NCT03481894_exc_R11", "type": "Has_index", "arg1_id": "NCT03481894_exc_T33", "arg2_id": "NCT03481894_exc_T34", "normalized": [] }, { "id": "NCT03481894_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03481894_exc_T32", "arg2_id": "NCT03481894_exc_T33", "normalized": [] }, { "id": "NCT03481894_exc_R13", "type": "Subsumes", "arg1_id": "NCT03481894_exc_T35", "arg2_id": "NCT03481894_exc_T41", "normalized": [] }, { "id": "NCT03481894_exc_R14", "type": "Has_value", "arg1_id": "NCT03481894_exc_T42", "arg2_id": "NCT03481894_exc_T40", "normalized": [] }, { "id": "NCT03481894_exc_R15", "type": "Subsumes", "arg1_id": "NCT03481894_exc_T44", "arg2_id": "NCT03481894_exc_T51", "normalized": [] }, { "id": "NCT03481894_exc_R16", "type": "Has_value", "arg1_id": "NCT03481894_exc_T44", "arg2_id": "NCT03481894_exc_T43", "normalized": [] }, { "id": "NCT03481894_exc_R17", "type": "Has_value", "arg1_id": "NCT03481894_exc_T57", "arg2_id": "NCT03481894_exc_T53", "normalized": [] } ]

[ { "id": "NCT03481894_inc_text", "type": "inclusion", "text": [ "Male or female patients 2 to 16 years of age\nPatients who require at least 80% of their caloric intake as PN at study start, and in whom an indication for PN is expected for at least 5 days\nPatients who require a central venous line to receive PN or already have a central venous line in place for other reasons\nWritten informed consent from legal representative(s)\n" ], "offsets": [ [ 0, 366 ] ] } ]

[ { "id": "NCT03481894_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T2", "type": "Person", "text": [ "female" ], "offsets": [ [ 8, 14 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T3", "type": "Value", "text": [ "2 to 16 years" ], "offsets": [ [ 24, 37 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 41, 44 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T5", "type": "Value", "text": [ "t least 80% of", "aloric intake" ], "offsets": [ [ 67, 81 ], [ 89, 102 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T6", "type": "Procedure", "text": [ "PN" ], "offsets": [ [ 106, 108 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T7", "type": "Temporal", "text": [ "at study start" ], "offsets": [ [ 109, 123 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T8", "type": "Condition", "text": [ "indication" ], "offsets": [ [ 140, 150 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T9", "type": "Procedure", "text": [ "PN" ], "offsets": [ [ 155, 157 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T10", "type": "Multiplier", "text": [ "for at least 5 days" ], "offsets": [ [ 170, 189 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T11", "type": "Mood", "text": [ "expected" ], "offsets": [ [ 161, 169 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T12", "type": "Device", "text": [ "central venous line" ], "offsets": [ [ 213, 232 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T13", "type": "Procedure", "text": [ "PN" ], "offsets": [ [ 244, 246 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T14", "type": "Device", "text": [ "central venous line" ], "offsets": [ [ 265, 284 ] ], "normalized": [] }, { "id": "NCT03481894_inc_T15", "type": "Observation", "text": [ "other reasons" ], "offsets": [ [ 298, 311 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03481894_inc_R1", "type": "Has_value", "arg1_id": "NCT03481894_inc_T4", "arg2_id": "NCT03481894_inc_T3", "normalized": [] }, { "id": "NCT03481894_inc_R2", "type": "Has_value", "arg1_id": "NCT03481894_inc_T6", "arg2_id": "NCT03481894_inc_T5", "normalized": [] }, { "id": "NCT03481894_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03481894_inc_T6", "arg2_id": "NCT03481894_inc_T7", "normalized": [] }, { "id": "NCT03481894_inc_R4", "type": "AND", "arg1_id": "NCT03481894_inc_T8", "arg2_id": "NCT03481894_inc_T9", "normalized": [] }, { "id": "NCT03481894_inc_R6", "type": "Has_mood", "arg1_id": "NCT03481894_inc_T10", "arg2_id": "NCT03481894_inc_T11", "normalized": [] }, { "id": "NCT03481894_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT03481894_inc_T8", "arg2_id": "NCT03481894_inc_T10", "normalized": [] }, { "id": "NCT03481894_inc_R7", "type": "AND", "arg1_id": "NCT03481894_inc_T12", "arg2_id": "NCT03481894_inc_T13", "normalized": [] } ]

[ { "id": "NCT03484091_exc_text", "type": "exclusion", "text": [ "Severe deformity (varus or values from mechanical axis more than 5 degrees\nAllergy to hyaluronic acid\nPain on hip or ankle\nPost-traumatic or post surgery of lower extremity\nPost infection of knee\nPrevious hyaluronic acid injection within 6 months\nPregnancy or lactation\nUnderlying Rheumatoid arthritis, stroke, malignancy, venous occlusion\n" ], "offsets": [ [ 0, 340 ] ] } ]

[ { "id": "NCT03484091_exc_T1", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T2", "type": "Condition", "text": [ "deformity" ], "offsets": [ [ 7, 16 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T3", "type": "Condition", "text": [ "varus" ], "offsets": [ [ 18, 23 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T4", "type": "Measurement", "text": [ "values from mechanical axis" ], "offsets": [ [ 27, 54 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T5", "type": "Value", "text": [ "more than 5 degrees" ], "offsets": [ [ 55, 74 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T6", "type": "Scope", "text": [ "varus or values from mechanical axis more than 5 degrees" ], "offsets": [ [ 18, 74 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T7", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 75, 82 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T8", "type": "Drug", "text": [ "hyaluronic acid" ], "offsets": [ [ 86, 101 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T9", "type": "Condition", "text": [ "Pain" ], "offsets": [ [ 102, 106 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T10", "type": "Qualifier", "text": [ "hip" ], "offsets": [ [ 110, 113 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T11", "type": "Qualifier", "text": [ "ankle" ], "offsets": [ [ 117, 122 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T12", "type": "Scope", "text": [ "hip or ankle" ], "offsets": [ [ 110, 122 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T13", "type": "Temporal", "text": [ "t-traumatic or", "lower extremity\nPo" ], "offsets": [ [ 126, 140 ], [ 157, 175 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T14", "type": "Temporal", "text": [ "post surgery of lower extremity" ], "offsets": [ [ 141, 172 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T15", "type": "Condition", "text": [ "infection of knee" ], "offsets": [ [ 178, 195 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T16", "type": "Temporal", "text": [ "Post" ], "offsets": [ [ 173, 177 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T17", "type": "Drug", "text": [ "hyaluronic acid" ], "offsets": [ [ 205, 220 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T18", "type": "Procedure", "text": [ "hyaluronic acid injection" ], "offsets": [ [ 205, 230 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T19", "type": "Temporal", "text": [ "within 6 months" ], "offsets": [ [ 231, 246 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T20", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 196, 204 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T21", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 247, 256 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T22", "type": "Condition", "text": [ "lactation" ], "offsets": [ [ 260, 269 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T23", "type": "Condition", "text": [ "Rheumatoid arthritis" ], "offsets": [ [ 281, 301 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T24", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 303, 309 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T25", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 311, 321 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T26", "type": "Condition", "text": [ "venous occlusion" ], "offsets": [ [ 323, 339 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T27", "type": "Scope", "text": [ "Rheumatoid arthritis, stroke, malignancy, venous occlusion" ], "offsets": [ [ 281, 339 ] ], "normalized": [] }, { "id": "NCT03484091_exc_T28", "type": "Qualifier", "text": [ "Underlying" ], "offsets": [ [ 270, 280 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03484091_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03484091_exc_T2", "arg2_id": "NCT03484091_exc_T1", "normalized": [] }, { "id": "NCT03484091_exc_R2", "type": "Has_value", "arg1_id": "NCT03484091_exc_T4", "arg2_id": "NCT03484091_exc_T5", "normalized": [] }, { "id": "NCT03484091_exc_R3", "type": "Subsumes", "arg1_id": "NCT03484091_exc_T2", "arg2_id": "NCT03484091_exc_T6", "normalized": [] }, { "id": "NCT03484091_exc_R4", "type": "AND", "arg1_id": "NCT03484091_exc_T7", "arg2_id": "NCT03484091_exc_T8", "normalized": [] }, { "id": "NCT03484091_exc_R5", "type": "Has_scope", "arg1_id": "NCT03484091_exc_T9", "arg2_id": "NCT03484091_exc_T12", "normalized": [] }, { "id": "NCT03484091_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03484091_exc_T15", "arg2_id": "NCT03484091_exc_T16", "normalized": [] }, { "id": "NCT03484091_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03484091_exc_T18", "arg2_id": "NCT03484091_exc_T19", "normalized": [] }, { "id": "NCT03484091_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03484091_exc_T18", "arg2_id": "NCT03484091_exc_T20", "normalized": [] }, { "id": "NCT03484091_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03484091_exc_T27", "arg2_id": "NCT03484091_exc_T28", "normalized": [] } ]

[ { "id": "NCT03484091_inc_text", "type": "inclusion", "text": [ "Symptomatic primary knee osteoarthritis with failed conservative treatment at least 3 months\nKellgren-Lawrence grade I-III\nGave informed consent\nCan do questionnaires\n" ], "offsets": [ [ 0, 167 ] ] } ]

[ { "id": "NCT03484091_inc_T1", "type": "Qualifier", "text": [ "Symptomatic" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T2", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 12, 19 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T3", "type": "Qualifier", "text": [ "knee" ], "offsets": [ [ 20, 24 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T4", "type": "Condition", "text": [ "osteoarthritis" ], "offsets": [ [ 25, 39 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T5", "type": "Procedure", "text": [ "conservative treatment" ], "offsets": [ [ 52, 74 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T6", "type": "Qualifier", "text": [ "failed" ], "offsets": [ [ 45, 51 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T7", "type": "Temporal", "text": [ "at least 3 months" ], "offsets": [ [ 75, 92 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T8", "type": "Measurement", "text": [ "Kellgren-Lawrence grade" ], "offsets": [ [ 93, 116 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T9", "type": "Value", "text": [ "I-III" ], "offsets": [ [ 117, 122 ] ], "normalized": [] }, { "id": "NCT03484091_inc_T11", "type": "Observation", "text": [ "Can do questionnaires" ], "offsets": [ [ 145, 166 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03484091_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03484091_inc_T4", "arg2_id": "NCT03484091_inc_T3", "normalized": [] }, { "id": "NCT03484091_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03484091_inc_T4", "arg2_id": "NCT03484091_inc_T2", "normalized": [] }, { "id": "NCT03484091_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03484091_inc_T4", "arg2_id": "NCT03484091_inc_T1", "normalized": [] }, { "id": "NCT03484091_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03484091_inc_T5", "arg2_id": "NCT03484091_inc_T6", "normalized": [] }, { "id": "NCT03484091_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03484091_inc_T5", "arg2_id": "NCT03484091_inc_T7", "normalized": [] }, { "id": "NCT03484091_inc_R6", "type": "Has_value", "arg1_id": "NCT03484091_inc_T8", "arg2_id": "NCT03484091_inc_T9", "normalized": [] } ]

[ { "id": "NCT03491059_exc_text", "type": "exclusion", "text": [ "not a regular user of e-cigarettes\npregnant or lactating (only excluded from imaging study)\nprisoner\nincapable of giving informed consent\nunable to lie flat on the scanner for extended periods of time\nunstable medical condition like heart disease, uncontrolled hypertension, thyroid disease, diabetes, renal or liver impairment, or glaucoma\nprostatic hypertrophy, stroke, or ulcer in past year\npsychiatric conditions such as schizophrenia, adult ADHD, or bipolar disorder\ncurrent or regular use of psychiatric medications such as tranquilizers, antipsychotics, and/or antidepressants\nuse of medications that are inducers of CYP2A6 (a nicotine metabolizing enzyme) such as rifampicin, dexamethasone, phenobarbital, and other anti-convulsant drugs\nunable to communicate in English\ncurrent use of smokeless tobacco, tobacco cigarettes (5 and fewer a day)\noccasional use of pipes is permitted if subject abstains for the week prior to the study\nolder than 80 years\n" ], "offsets": [ [ 0, 961 ] ] } ]

[ { "id": "NCT03491059_exc_T1", "type": "Person", "text": [ "regular user" ], "offsets": [ [ 6, 18 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T2", "type": "Procedure", "text": [ "e-cigarettes" ], "offsets": [ [ 22, 34 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T3", "type": "Negation", "text": [ "not" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T5", "type": "Person", "text": [ "prisoner" ], "offsets": [ [ 92, 100 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T8", "type": "Qualifier", "text": [ "unstable" ], "offsets": [ [ 201, 209 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T9", "type": "Condition", "text": [ "medical condition" ], "offsets": [ [ 210, 227 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T10", "type": "Condition", "text": [ "heart disease" ], "offsets": [ [ 233, 246 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T11", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 261, 273 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T12", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 248, 260 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T13", "type": "Condition", "text": [ "thyroid disease" ], "offsets": [ [ 275, 290 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T14", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 292, 300 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T15", "type": "Condition", "text": [ "liver impairment" ], "offsets": [ [ 311, 327 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T16", "type": "Condition", "text": [ " or ", "rment, or" ], "offsets": [ [ 307, 311 ], [ 322, 331 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T17", "type": "Condition", "text": [ "glaucoma" ], "offsets": [ [ 332, 340 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T18", "type": "Scope", "text": [ "heart disease, uncontrolled hypertension, thyroid disease, diabetes, renal or liver impairment, or glaucom" ], "offsets": [ [ 233, 339 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T19", "type": "Condition", "text": [ "prostatic hypertrophy" ], "offsets": [ [ 341, 362 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T20", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 364, 370 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T21", "type": "Condition", "text": [ "ulcer" ], "offsets": [ [ 375, 380 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T22", "type": "Condition", "text": [ "psychiatric conditions" ], "offsets": [ [ 394, 416 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T23", "type": "Condition", "text": [ "schizophrenia" ], "offsets": [ [ 425, 438 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T24", "type": "Condition", "text": [ "adult ADHD" ], "offsets": [ [ 440, 450 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T25", "type": "Condition", "text": [ "bipolar disorder" ], "offsets": [ [ 455, 471 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T26", "type": "Scope", "text": [ "schizophrenia, adult ADHD, or bipolar disorder" ], "offsets": [ [ 425, 471 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T27", "type": "Drug", "text": [ "psychiatric medications" ], "offsets": [ [ 498, 521 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T28", "type": "Drug", "text": [ "tranquilizers" ], "offsets": [ [ 530, 543 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T29", "type": "Drug", "text": [ "antipsychotics" ], "offsets": [ [ 545, 559 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T30", "type": "Drug", "text": [ "antidepressants" ], "offsets": [ [ 568, 583 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T31", "type": "Scope", "text": [ "tranquilizers, antipsychotics, and/or antidepressants" ], "offsets": [ [ 530, 583 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T32", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 591, 602 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T33", "type": "Qualifier", "text": [ "inducers of CYP2A6" ], "offsets": [ [ 612, 630 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T34", "type": "Drug", "text": [ "nicotine metabolizing enzyme" ], "offsets": [ [ 634, 662 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T35", "type": "Drug", "text": [ "rifampicin" ], "offsets": [ [ 672, 682 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T36", "type": "Drug", "text": [ "dexamethasone" ], "offsets": [ [ 684, 697 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T37", "type": "Drug", "text": [ "phenobarbital" ], "offsets": [ [ 699, 712 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T38", "type": "Drug", "text": [ "anti-convulsant drugs" ], "offsets": [ [ 724, 745 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T39", "type": "Scope", "text": [ "rifampicin, dexamethasone, phenobarbital, and other anti-convulsant drugs" ], "offsets": [ [ 672, 745 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T41", "type": "Procedure", "text": [ "smokeless tobacco" ], "offsets": [ [ 794, 811 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T42", "type": "Procedure", "text": [ "tobacco cigarettes" ], "offsets": [ [ 813, 831 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T43", "type": "Multiplier", "text": [ "5 and fewer a day" ], "offsets": [ [ 833, 850 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T44", "type": "Scope", "text": [ "smokeless tobacco, tobacco cigarettes" ], "offsets": [ [ 794, 831 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T46", "type": "Person", "text": [ "years" ], "offsets": [ [ 955, 960 ] ], "normalized": [] }, { "id": "NCT03491059_exc_T47", "type": "Value", "text": [ "older than 80" ], "offsets": [ [ 941, 954 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03491059_exc_R1", "type": "AND", "arg1_id": "NCT03491059_exc_T1", "arg2_id": "NCT03491059_exc_T2", "normalized": [] }, { "id": "NCT03491059_exc_R2", "type": "Has_negation", "arg1_id": "NCT03491059_exc_T1", "arg2_id": "NCT03491059_exc_T3", "normalized": [] }, { "id": "NCT03491059_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03491059_exc_T9", "arg2_id": "NCT03491059_exc_T8", "normalized": [] }, { "id": "NCT03491059_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03491059_exc_T11", "arg2_id": "NCT03491059_exc_T12", "normalized": [] }, { "id": "NCT03491059_exc_R5", "type": "Subsumes", "arg1_id": "NCT03491059_exc_T9", "arg2_id": "NCT03491059_exc_T18", "normalized": [] }, { "id": "NCT03491059_exc_R6", "type": "Subsumes", "arg1_id": "NCT03491059_exc_T22", "arg2_id": "NCT03491059_exc_T26", "normalized": [] }, { "id": "NCT03491059_exc_R7", "type": "Subsumes", "arg1_id": "NCT03491059_exc_T27", "arg2_id": "NCT03491059_exc_T31", "normalized": [] }, { "id": "NCT03491059_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03491059_exc_T32", "arg2_id": "NCT03491059_exc_T33", "normalized": [] }, { "id": "NCT03491059_exc_R9", "type": "Subsumes", "arg1_id": "NCT03491059_exc_T32", "arg2_id": "NCT03491059_exc_T39", "normalized": [] }, { "id": "NCT03491059_exc_R10", "type": "Subsumes", "arg1_id": "NCT03491059_exc_T32", "arg2_id": "NCT03491059_exc_T34", "normalized": [] }, { "id": "NCT03491059_exc_R11", "type": "Has_multiplier", "arg1_id": "NCT03491059_exc_T44", "arg2_id": "NCT03491059_exc_T43", "normalized": [] }, { "id": "NCT03491059_exc_R12", "type": "Has_value", "arg1_id": "NCT03491059_exc_T46", "arg2_id": "NCT03491059_exc_T47", "normalized": [] } ]

[ { "id": "NCT03491059_inc_text", "type": "inclusion", "text": [ "males and females greater than or equal to 18 years of age\ncurrent regular user of e-cigarettes (use at least once daily for the past 30 days) with nicotine strength > 6mg/ml\nhealth medical history\nabstinent from any tobacco/nicotine use for 4 hours prior to imaging\n" ], "offsets": [ [ 0, 267 ] ] } ]

[ { "id": "NCT03491059_inc_T1", "type": "Person", "text": [ "males" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T2", "type": "Person", "text": [ "females" ], "offsets": [ [ 10, 17 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 55, 58 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T4", "type": "Value", "text": [ "greater than or equal to 18 years" ], "offsets": [ [ 18, 51 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T5", "type": "Person", "text": [ "user" ], "offsets": [ [ 75, 79 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T6", "type": "Qualifier", "text": [ "regular" ], "offsets": [ [ 67, 74 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T7", "type": "Qualifier", "text": [ "e-cigarettes" ], "offsets": [ [ 83, 95 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T8", "type": "Multiplier", "text": [ "at least once daily" ], "offsets": [ [ 101, 120 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T9", "type": "Temporal", "text": [ "for the past 30 days" ], "offsets": [ [ 121, 141 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T10", "type": "Measurement", "text": [ "nicotine strength" ], "offsets": [ [ 148, 165 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T11", "type": "Value", "text": [ "> 6mg/ml" ], "offsets": [ [ 166, 174 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T12", "type": "Observation", "text": [ "medical history" ], "offsets": [ [ 182, 197 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T13", "type": "Qualifier", "text": [ "health" ], "offsets": [ [ 175, 181 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T14", "type": "Condition", "text": [ "abstinent" ], "offsets": [ [ 198, 207 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T15", "type": "Drug", "text": [ "tobacco" ], "offsets": [ [ 217, 224 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T16", "type": "Drug", "text": [ "nicotine" ], "offsets": [ [ 225, 233 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T17", "type": "Scope", "text": [ "tobacco/nicotine" ], "offsets": [ [ 217, 233 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T18", "type": "Temporal", "text": [ "for 4 hours prior to imaging" ], "offsets": [ [ 238, 266 ] ], "normalized": [] }, { "id": "NCT03491059_inc_T19", "type": "Reference_point", "text": [ "imaging" ], "offsets": [ [ 259, 266 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03491059_inc_R1", "type": "Has_value", "arg1_id": "NCT03491059_inc_T3", "arg2_id": "NCT03491059_inc_T4", "normalized": [] }, { "id": "NCT03491059_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03491059_inc_T5", "arg2_id": "NCT03491059_inc_T6", "normalized": [] }, { "id": "NCT03491059_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03491059_inc_T5", "arg2_id": "NCT03491059_inc_T7", "normalized": [] }, { "id": "NCT03491059_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT03491059_inc_T7", "arg2_id": "NCT03491059_inc_T8", "normalized": [] }, { "id": "NCT03491059_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03491059_inc_T7", "arg2_id": "NCT03491059_inc_T9", "normalized": [] }, { "id": "NCT03491059_inc_R6", "type": "Has_value", "arg1_id": "NCT03491059_inc_T10", "arg2_id": "NCT03491059_inc_T11", "normalized": [] }, { "id": "NCT03491059_inc_R7", "type": "AND", "arg1_id": "NCT03491059_inc_T5", "arg2_id": "NCT03491059_inc_T10", "normalized": [] }, { "id": "NCT03491059_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03491059_inc_T12", "arg2_id": "NCT03491059_inc_T13", "normalized": [] }, { "id": "NCT03491059_inc_R9", "type": "Has_scope", "arg1_id": "NCT03491059_inc_T14", "arg2_id": "NCT03491059_inc_T17", "normalized": [] }, { "id": "NCT03491059_inc_R10", "type": "Has_index", "arg1_id": "NCT03491059_inc_T18", "arg2_id": "NCT03491059_inc_T19", "normalized": [] }, { "id": "NCT03491059_inc_R11", "type": "Has_temporal", "arg1_id": "NCT03491059_inc_T14", "arg2_id": "NCT03491059_inc_T18", "normalized": [] } ]

[ { "id": "NCT03493919_exc_text", "type": "exclusion", "text": [ "Progressive, unstable or uncontrolled clinical conditions.\nHypersensitivity, including allergy, to any component of vaccines, medicinal products or medical equipment whose use is foreseen in this study.\nClinical conditions representing a contraindication to intramuscular vaccination and blood draws.\nClinical conditions.\nSystemic administration of corticosteroids (PO/IV/IM) within 90 days prior to informed consent.\nAdministration of antineoplastic and immunomodulating agents or radiotherapy within 90 days prior to informed consent.\nReceived immunoglobulins or any blood products within 180 days prior to informed consent.\nReceived an investigational or non-registered medicinal product within 30 days prior to informed consent.\nAny other clinical condition that, in the opinion of the investigator, might pose additional risk to the subject due to participation in the study.\nAny history of meningococcal vaccination or meningococcal and gonorrhoea diseases.\nEnrolment in any activity requiring a blood donation greater than 50 mL during the period starting 30 days before the first study visit (Day -83, Day -60 or Day -30) or for the duration of the study period.\nAdministration of long-acting immune-modifying drugs at any time during the study period\nSubjects with blood disorders.\nSubjects with a history of difficulty in providing blood samples\nAny antibiotic intake 7 days prior to blood collection.\nSubjects who donated >450 mL of blood within 60 days prior to any blood collection visits.\nSubjects who lost >200 mL during a single apheresis or who lost red blood cells on more than one occasion during apheresis within the previous 60 days.\nConcurrently participating in another clinical study, at any time during the study period, in which the subject has been or will be exposed to an investigational or a non-investigational vaccine/product\nOngoing anaemia as indicated by haemoglobin values below the lower limit of the laboratory-specified reference range. If the finger prick method demonstrates an anaemia, no further protocol procedures will be performed, and the subject will be referred for appropriate medical management. The subject may participate in this study following therapy and evidence that the anaemia has been resolved.\nHistory of any reaction or hypersensitivity likely to be exacerbated by any component of the vaccines.\nPregnant or lactating female.\nFemale planning to become pregnant or planning to discontinue contraceptive precautions.\nAny confirmed or suspected immunosuppressive or immunodeficiency condition based on medical history and physical examination\nFamily history of congenital or hereditary immunodeficiency.\nSerious chronic illness.\nHistory of chronic alcohol consumption and/or drug abuse.\n" ], "offsets": [ [ 0, 2747 ] ] } ]

[ { "id": "NCT03493919_exc_T1", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 25, 37 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T2", "type": "Qualifier", "text": [ "unstable" ], "offsets": [ [ 13, 21 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T3", "type": "Qualifier", "text": [ "Progressive" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T4", "type": "Condition", "text": [ "clinical conditions" ], "offsets": [ [ 38, 57 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T5", "type": "Scope", "text": [ "Progressive, unstable or uncontrolled" ], "offsets": [ [ 0, 37 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T6", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 59, 75 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T7", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 87, 94 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T8", "type": "Drug", "text": [ "component of vaccines" ], "offsets": [ [ 103, 124 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T9", "type": "Drug", "text": [ "medicinal products" ], "offsets": [ [ 126, 144 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T10", "type": "Device", "text": [ "medical equipment" ], "offsets": [ [ 148, 165 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T11", "type": "Qualifier", "text": [ "whose use is foreseen in this study" ], "offsets": [ [ 166, 201 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T12", "type": "Scope", "text": [ "component of vaccines, medicinal products or medical equipment" ], "offsets": [ [ 103, 165 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T13", "type": "Scope", "text": [ "Hypersensitivity, including allergy" ], "offsets": [ [ 59, 94 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T14", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 238, 254 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T15", "type": "Procedure", "text": [ "intramuscular vaccination" ], "offsets": [ [ 258, 283 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T16", "type": "Procedure", "text": [ "blood draws" ], "offsets": [ [ 288, 299 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T17", "type": "Scope", "text": [ "intramuscular vaccination and blood draws" ], "offsets": [ [ 258, 299 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T19", "type": "Qualifier", "text": [ "Systemic administration" ], "offsets": [ [ 322, 345 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T20", "type": "Drug", "text": [ "corticosteroids" ], "offsets": [ [ 349, 364 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T21", "type": "Qualifier", "text": [ "PO" ], "offsets": [ [ 366, 368 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T22", "type": "Qualifier", "text": [ "IV" ], "offsets": [ [ 369, 371 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T23", "type": "Qualifier", "text": [ "IM" ], "offsets": [ [ 372, 374 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T24", "type": "Scope", "text": [ "PO/IV/IM" ], "offsets": [ [ 366, 374 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T25", "type": "Temporal", "text": [ "within 90 days prior to informed consent" ], "offsets": [ [ 376, 416 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T26", "type": "Reference_point", "text": [ "informed consent" ], "offsets": [ [ 400, 416 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T27", "type": "Drug", "text": [ "immunomodulating agents" ], "offsets": [ [ 455, 478 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T28", "type": "Drug", "text": [ "eoplastic and", "s or r" ], "offsets": [ [ 441, 454 ], [ 477, 483 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T29", "type": "Procedure", "text": [ "radiotherapy" ], "offsets": [ [ 482, 494 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T30", "type": "Temporal", "text": [ "within 90 days prior to informed consent" ], "offsets": [ [ 495, 535 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T31", "type": "Reference_point", "text": [ "informed consent" ], "offsets": [ [ 519, 535 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T32", "type": "Scope", "text": [ "antineoplastic and immunomodulating agents or radiotherapy" ], "offsets": [ [ 436, 494 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T33", "type": "Drug", "text": [ "immunoglobulins" ], "offsets": [ [ 546, 561 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T34", "type": "Drug", "text": [ "blood products" ], "offsets": [ [ 569, 583 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T35", "type": "Temporal", "text": [ "within 180 days prior to informed consent" ], "offsets": [ [ 584, 625 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T36", "type": "Reference_point", "text": [ "informed consent" ], "offsets": [ [ 609, 625 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T37", "type": "Scope", "text": [ "immunoglobulins or any blood products" ], "offsets": [ [ 546, 583 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T38", "type": "Qualifier", "text": [ "investigational" ], "offsets": [ [ 639, 654 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T39", "type": "Qualifier", "text": [ "non-registered" ], "offsets": [ [ 658, 672 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T40", "type": "Drug", "text": [ "medicinal product" ], "offsets": [ [ 673, 690 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T41", "type": "Temporal", "text": [ "within 30 days prior to informed consent" ], "offsets": [ [ 691, 731 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T42", "type": "Reference_point", "text": [ "informed consent" ], "offsets": [ [ 715, 731 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T43", "type": "Scope", "text": [ "investigational or non-registered" ], "offsets": [ [ 639, 672 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T45", "type": "Drug", "text": [ "meningococcal vaccination" ], "offsets": [ [ 896, 921 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T46", "type": "Observation", "text": [ "history" ], "offsets": [ [ 885, 892 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T47", "type": "Condition", "text": [ "ccal and gono", "\nEnrolm" ], "offsets": [ [ 934, 947 ], [ 963, 970 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T48", "type": "Condition", "text": [ "gonorrhoea diseases" ], "offsets": [ [ 943, 962 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T49", "type": "Scope", "text": [ "meningococcal vaccination or meningococcal and gonorrhoea diseases" ], "offsets": [ [ 896, 962 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T50", "type": "Procedure", "text": [ "blood donation" ], "offsets": [ [ 1002, 1016 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T52", "type": "Multiplier", "text": [ "greater than 50 mL" ], "offsets": [ [ 1017, 1035 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T53", "type": "Temporal", "text": [ "during the period starting 30 days before the first study visit" ], "offsets": [ [ 1036, 1099 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T54", "type": "Reference_point", "text": [ "30 days before the first study visit" ], "offsets": [ [ 1063, 1099 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T55", "type": "Temporal", "text": [ "for the duration of the study period" ], "offsets": [ [ 1133, 1169 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T56", "type": "Reference_point", "text": [ "the study period" ], "offsets": [ [ 1153, 1169 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T57", "type": "Scope", "text": [ "during the period starting 30 days before the first study visit (Day -83, Day -60 or Day -30) or for the duration of the study period" ], "offsets": [ [ 1036, 1169 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T58", "type": "Drug", "text": [ "immune-modifying drugs" ], "offsets": [ [ 1201, 1223 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T59", "type": "Temporal", "text": [ "at any time during the study period" ], "offsets": [ [ 1224, 1259 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T60", "type": "Reference_point", "text": [ "the study period" ], "offsets": [ [ 1243, 1259 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T61", "type": "Qualifier", "text": [ "long-acting" ], "offsets": [ [ 1189, 1200 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T62", "type": "Condition", "text": [ "blood disorders" ], "offsets": [ [ 1274, 1289 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T63", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1307, 1314 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T64", "type": "Observation", "text": [ "difficulty in providing blood samples" ], "offsets": [ [ 1318, 1355 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T65", "type": "Drug", "text": [ "antibiotic" ], "offsets": [ [ 1360, 1370 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T66", "type": "Temporal", "text": [ "7 days prior to blood collection" ], "offsets": [ [ 1378, 1410 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T67", "type": "Reference_point", "text": [ "blood collection" ], "offsets": [ [ 1394, 1410 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T68", "type": "Procedure", "text": [ " of bl", " day" ], "offsets": [ [ 1440, 1446 ], [ 1459, 1463 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T69", "type": "Value", "text": [ ">450 mL" ], "offsets": [ [ 1433, 1440 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T70", "type": "Temporal", "text": [ "within 60 days prior to any blood collection visits" ], "offsets": [ [ 1450, 1501 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T71", "type": "Reference_point", "text": [ "any blood collection visits" ], "offsets": [ [ 1474, 1501 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T72", "type": "Measurement", "text": [ "lost red blood cells" ], "offsets": [ [ 1562, 1582 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T73", "type": "Value", "text": [ ">200 mL" ], "offsets": [ [ 1521, 1528 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T74", "type": "Multiplier", "text": [ "single" ], "offsets": [ [ 1538, 1544 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T75", "type": "Procedure", "text": [ "apheresis" ], "offsets": [ [ 1545, 1554 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T76", "type": "Procedure", "text": [ "apheresis" ], "offsets": [ [ 1616, 1625 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T77", "type": "Multiplier", "text": [ "more than one occasion" ], "offsets": [ [ 1586, 1608 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T78", "type": "Temporal", "text": [ "within the previous 60 days" ], "offsets": [ [ 1626, 1653 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T79", "type": "Reference_point", "text": [ "the previous 60 days" ], "offsets": [ [ 1633, 1653 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T80", "type": "Temporal", "text": [ "Concurrently" ], "offsets": [ [ 1655, 1667 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T81", "type": "Observation", "text": [ "another clinical", "t any time dur" ], "offsets": [ [ 1685, 1701 ], [ 1710, 1724 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T82", "type": "Temporal", "text": [ "at any time during the study period" ], "offsets": [ [ 1709, 1744 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T83", "type": "Reference_point", "text": [ "the study period" ], "offsets": [ [ 1728, 1744 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T84", "type": "Drug", "text": [ "vaccine" ], "offsets": [ [ 1842, 1849 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T85", "type": "Drug", "text": [ "product" ], "offsets": [ [ 1850, 1857 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T86", "type": "Scope", "text": [ "vaccine/product" ], "offsets": [ [ 1842, 1857 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T87", "type": "Qualifier", "text": [ "investigational" ], "offsets": [ [ 1826, 1841 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T88", "type": "Qualifier", "text": [ "non-investigational" ], "offsets": [ [ 1822, 1841 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T89", "type": "Scope", "text": [ "investigational or a non-investigational" ], "offsets": [ [ 1801, 1841 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T90", "type": "Temporal", "text": [ "Ongoing" ], "offsets": [ [ 1858, 1865 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T91", "type": "Condition", "text": [ "anaemia" ], "offsets": [ [ 1866, 1873 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T92", "type": "Measurement", "text": [ "haemoglobin" ], "offsets": [ [ 1890, 1901 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T93", "type": "Value", "text": [ "below the lower limit of the laboratory-specified reference range" ], "offsets": [ [ 1909, 1974 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T94", "type": "Procedure", "text": [ "finger prick method" ], "offsets": [ [ 1983, 2002 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T95", "type": "Condition", "text": [ "anaemia" ], "offsets": [ [ 2019, 2026 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T97", "type": "Condition", "text": [ "reaction" ], "offsets": [ [ 2271, 2279 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T98", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 2283, 2299 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T99", "type": "Qualifier", "text": [ "likely to be exacerbated by any component of the vaccines" ], "offsets": [ [ 2300, 2357 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T100", "type": "Drug", "text": [ "component of the vaccines" ], "offsets": [ [ 2332, 2357 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T101", "type": "Scope", "text": [ "reaction or hypersensitivity" ], "offsets": [ [ 2271, 2299 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T102", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 2359, 2367 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T103", "type": "Observation", "text": [ "lactating" ], "offsets": [ [ 2371, 2380 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T104", "type": "Person", "text": [ "female" ], "offsets": [ [ 2381, 2387 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T105", "type": "Person", "text": [ "Female" ], "offsets": [ [ 2389, 2395 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T106", "type": "Observation", "text": [ "planning to become pregnant" ], "offsets": [ [ 2396, 2423 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T107", "type": "Mood", "text": [ "planning to discontinue" ], "offsets": [ [ 2427, 2450 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T108", "type": "Observation", "text": [ "contraceptive precautions" ], "offsets": [ [ 2451, 2476 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T109", "type": "Mood", "text": [ "planning to" ], "offsets": [ [ 2427, 2438 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T110", "type": "Observation", "text": [ "become pregnant" ], "offsets": [ [ 2408, 2423 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T111", "type": "Qualifier", "text": [ "confirmed" ], "offsets": [ [ 2482, 2491 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T112", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 2495, 2504 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T113", "type": "Condition", "text": [ "mmunodeficiency c", "ical hist" ], "offsets": [ [ 2527, 2544 ], [ 2565, 2574 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T114", "type": "Condition", "text": [ "immunodeficiency condition" ], "offsets": [ [ 2526, 2552 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T115", "type": "Observation", "text": [ "medical history" ], "offsets": [ [ 2562, 2577 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T116", "type": "Procedure", "text": [ "physical examination" ], "offsets": [ [ 2582, 2602 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T117", "type": "Scope", "text": [ "medical history and physical examination" ], "offsets": [ [ 2562, 2602 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T118", "type": "Scope", "text": [ "immunosuppressive or immunodeficiency condition" ], "offsets": [ [ 2505, 2552 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T119", "type": "Scope", "text": [ "confirmed or suspected" ], "offsets": [ [ 2482, 2504 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T120", "type": "Observation", "text": [ "Family history" ], "offsets": [ [ 2603, 2617 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T121", "type": "Condition", "text": [ "hereditary immunodeficiency" ], "offsets": [ [ 2635, 2662 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T122", "type": "Condition", "text": [ "y immunode", "us chronic illne" ], "offsets": [ [ 2644, 2654 ], [ 2669, 2685 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T123", "type": "Scope", "text": [ "congenital or hereditary immunodeficiency" ], "offsets": [ [ 2621, 2662 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T124", "type": "Qualifier", "text": [ "Serious" ], "offsets": [ [ 2664, 2671 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T125", "type": "Condition", "text": [ "chronic illness" ], "offsets": [ [ 2672, 2687 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T126", "type": "Condition", "text": [ "chronic alcohol consumption" ], "offsets": [ [ 2700, 2727 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T127", "type": "Condition", "text": [ "drug abuse" ], "offsets": [ [ 2735, 2745 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T128", "type": "Observation", "text": [ "History" ], "offsets": [ [ 2689, 2696 ] ], "normalized": [] }, { "id": "NCT03493919_exc_T129", "type": "Scope", "text": [ "chronic alcohol consumption and/or drug abuse" ], "offsets": [ [ 2700, 2745 ] ], "normalized": [] } ]

[]

[]

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"NCT03493919_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T19", "arg2_id": "NCT03493919_exc_T25", "normalized": [] }, { "id": "NCT03493919_exc_R9", "type": "Has_index", "arg1_id": "NCT03493919_exc_T30", "arg2_id": "NCT03493919_exc_T31", "normalized": [] }, { "id": "NCT03493919_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T32", "arg2_id": "NCT03493919_exc_T30", "normalized": [] }, { "id": "NCT03493919_exc_R11", "type": "Has_index", "arg1_id": "NCT03493919_exc_T35", "arg2_id": "NCT03493919_exc_T36", "normalized": [] }, { "id": "NCT03493919_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T37", "arg2_id": "NCT03493919_exc_T35", "normalized": [] }, { "id": "NCT03493919_exc_R13", "type": "Has_index", "arg1_id": "NCT03493919_exc_T41", "arg2_id": "NCT03493919_exc_T42", "normalized": [] }, { "id": "NCT03493919_exc_R14", "type": "Has_scope", "arg1_id": "NCT03493919_exc_T40", "arg2_id": "NCT03493919_exc_T43", "normalized": [] }, { "id": "NCT03493919_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T40", "arg2_id": "NCT03493919_exc_T41", "normalized": [] }, { "id": "NCT03493919_exc_R16", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T49", "arg2_id": "NCT03493919_exc_T46", "normalized": [] }, { "id": "NCT03493919_exc_R17", "type": "Has_multiplier", "arg1_id": "NCT03493919_exc_T50", "arg2_id": "NCT03493919_exc_T52", "normalized": [] }, { "id": "NCT03493919_exc_R18", "type": "Has_index", "arg1_id": "NCT03493919_exc_T53", "arg2_id": "NCT03493919_exc_T54", "normalized": [] }, { "id": "NCT03493919_exc_R20", "type": "Has_index", "arg1_id": "NCT03493919_exc_T55", "arg2_id": "NCT03493919_exc_T56", "normalized": [] }, { "id": "NCT03493919_exc_R19", "type": "Has_scope", "arg1_id": "NCT03493919_exc_T50", "arg2_id": "NCT03493919_exc_T57", "normalized": [] }, { "id": "NCT03493919_exc_R21", "type": "Has_index", "arg1_id": "NCT03493919_exc_T59", "arg2_id": "NCT03493919_exc_T60", "normalized": [] }, { "id": "NCT03493919_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T58", "arg2_id": "NCT03493919_exc_T59", "normalized": [] }, { "id": "NCT03493919_exc_R23", "type": "Has_qualifier", "arg1_id": "NCT03493919_exc_T58", "arg2_id": "NCT03493919_exc_T61", "normalized": [] }, { "id": "NCT03493919_exc_R24", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T64", "arg2_id": "NCT03493919_exc_T63", "normalized": [] }, { "id": "NCT03493919_exc_R25", "type": "Has_index", "arg1_id": "NCT03493919_exc_T66", "arg2_id": "NCT03493919_exc_T67", "normalized": [] }, { "id": "NCT03493919_exc_R26", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T65", "arg2_id": "NCT03493919_exc_T66", "normalized": [] }, { "id": "NCT03493919_exc_R27", "type": "Has_index", "arg1_id": "NCT03493919_exc_T70", "arg2_id": "NCT03493919_exc_T71", "normalized": [] }, { "id": "NCT03493919_exc_R28", "type": "Has_value", "arg1_id": "NCT03493919_exc_T68", "arg2_id": "NCT03493919_exc_T69", "normalized": [] }, { "id": "NCT03493919_exc_R29", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T68", "arg2_id": "NCT03493919_exc_T70", "normalized": [] }, { "id": "NCT03493919_exc_R30", "type": "Has_value", "arg1_id": "NCT03493919_exc_T72", "arg2_id": "NCT03493919_exc_T73", "normalized": [] }, { "id": "NCT03493919_exc_R31", "type": "Has_multiplier", "arg1_id": "NCT03493919_exc_T75", "arg2_id": "NCT03493919_exc_T74", "normalized": [] }, { "id": "NCT03493919_exc_R32", "type": "AND", "arg1_id": "NCT03493919_exc_T75", "arg2_id": "NCT03493919_exc_T72", "normalized": [] }, { "id": "NCT03493919_exc_R33", "type": "Has_index", "arg1_id": "NCT03493919_exc_T78", "arg2_id": "NCT03493919_exc_T79", "normalized": [] }, { "id": "NCT03493919_exc_R34", "type": "Has_multiplier", "arg1_id": "NCT03493919_exc_T76", "arg2_id": "NCT03493919_exc_T77", "normalized": [] }, { "id": "NCT03493919_exc_R35", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T76", "arg2_id": "NCT03493919_exc_T78", "normalized": [] }, { "id": "NCT03493919_exc_R36", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T81", "arg2_id": "NCT03493919_exc_T80", "normalized": [] }, { "id": "NCT03493919_exc_R37", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T81", "arg2_id": "NCT03493919_exc_T82", "normalized": [] }, { "id": "NCT03493919_exc_R38", "type": "Has_index", "arg1_id": "NCT03493919_exc_T82", "arg2_id": "NCT03493919_exc_T83", "normalized": [] }, { "id": "NCT03493919_exc_R39", "type": "Has_scope", "arg1_id": "NCT03493919_exc_T86", "arg2_id": "NCT03493919_exc_T89", "normalized": [] }, { "id": "NCT03493919_exc_R40", "type": "Has_scope", "arg1_id": "NCT03493919_exc_T81", "arg2_id": "NCT03493919_exc_T86", "normalized": [] }, { "id": "NCT03493919_exc_R41", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T91", "arg2_id": "NCT03493919_exc_T90", "normalized": [] }, { "id": "NCT03493919_exc_R42", "type": "Has_value", "arg1_id": "NCT03493919_exc_T92", "arg2_id": "NCT03493919_exc_T93", "normalized": [] }, { "id": "NCT03493919_exc_R43", "type": "AND", "arg1_id": "NCT03493919_exc_T91", "arg2_id": "NCT03493919_exc_T92", "normalized": [] }, { "id": "NCT03493919_exc_R44", "type": "AND", "arg1_id": "NCT03493919_exc_T94", "arg2_id": "NCT03493919_exc_T95", "normalized": [] }, { "id": "NCT03493919_exc_R46", "type": "Has_qualifier", "arg1_id": "NCT03493919_exc_T101", "arg2_id": "NCT03493919_exc_T99", "normalized": [] }, { "id": "NCT03493919_exc_R47", "type": "Has_mood", "arg1_id": "NCT03493919_exc_T108", "arg2_id": "NCT03493919_exc_T107", "normalized": [] }, { "id": "NCT03493919_exc_R49", "type": "Has_mood", "arg1_id": "NCT03493919_exc_T110", "arg2_id": "NCT03493919_exc_T109", "normalized": [] }, { "id": "NCT03493919_exc_R50", "type": "Has_scope", "arg1_id": "NCT03493919_exc_T118", "arg2_id": "NCT03493919_exc_T119", "normalized": [] }, { "id": "NCT03493919_exc_R51", "type": "Has_scope", "arg1_id": "NCT03493919_exc_T118", "arg2_id": "NCT03493919_exc_T117", "normalized": [] }, { "id": "NCT03493919_exc_R53", "type": "Has_qualifier", "arg1_id": "NCT03493919_exc_T125", "arg2_id": "NCT03493919_exc_T124", "normalized": [] }, { "id": "NCT03493919_exc_R54", "type": "Has_temporal", "arg1_id": "NCT03493919_exc_T129", "arg2_id": "NCT03493919_exc_T128", "normalized": [] } ]

[ { "id": "NCT03493919_inc_text", "type": "inclusion", "text": [ "Subjects who, in the opinion of the investigator, can and will comply with the requirements of the protocol.\nWritten informed consent obtained from the subject prior to performing any study specific procedure.\nA male or female between, and including, 18 and 50 years of age at the time of the first study visit.\nHealthy subjects as established by medical history and clinical examination before entering into the study. Healthy subjects with no medical conditions that, in the opinion of the investigator, prevents the subject from participating in the study.\nSubjects must weigh at least 110 pounds (50 kg), but not to present obesity (BMI < 32kg/m2).\nFemale subjects of non-childbearing potential may be enrolled in the study. Non-childbearing potential is defined as pre-menarche, current bilateral tubal ligation or occlusion, hysterectomy, bilateral ovariectomy or post-menopause.\nhas practiced adequate contraception for 30 days prior to vaccination, and\nhas a negative pregnancy test on the day of vaccination and\nhas agreed to continue adequate contraception during the entire treatment period and for 1 month, after completion of the vaccination series.\n" ], "offsets": [ [ 0, 1163 ] ] } ]

[ { "id": "NCT03493919_inc_T2", "type": "Observation", "text": [ "comply with the requirements of the protocol" ], "offsets": [ [ 63, 107 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T3", "type": "Observation", "text": [ "Written informed consent" ], "offsets": [ [ 109, 133 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T4", "type": "Procedure", "text": [ "study specific procedure" ], "offsets": [ [ 184, 208 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T5", "type": "Temporal", "text": [ "prior to performing any study specific procedure" ], "offsets": [ [ 160, 208 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T6", "type": "Reference_point", "text": [ "performing any study specific procedure" ], "offsets": [ [ 169, 208 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T7", "type": "Person", "text": [ "male" ], "offsets": [ [ 212, 216 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T8", "type": "Person", "text": [ "female" ], "offsets": [ [ 220, 226 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T9", "type": "Value", "text": [ "18 and 50 years" ], "offsets": [ [ 251, 266 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T10", "type": "Person", "text": [ "age" ], "offsets": [ [ 270, 273 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T11", "type": "Temporal", "text": [ "at the time of the first study visit" ], "offsets": [ [ 274, 310 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T12", "type": "Reference_point", "text": [ "the first study visit" ], "offsets": [ [ 289, 310 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T13", "type": "Condition", "text": [ "Healthy" ], "offsets": [ [ 312, 319 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T14", "type": "Observation", "text": [ "medical history" ], "offsets": [ [ 347, 362 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T15", "type": "Procedure", "text": [ "clinical examination" ], "offsets": [ [ 367, 387 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T16", "type": "Temporal", "text": [ "before entering into the study" ], "offsets": [ [ 388, 418 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T17", "type": "Reference_point", "text": [ "entering into the study" ], "offsets": [ [ 395, 418 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T19", "type": "Measurement", "text": [ "weigh" ], "offsets": [ [ 574, 579 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T20", "type": "Value", "text": [ "at least 110 pounds" ], "offsets": [ [ 580, 599 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T21", "type": "Value", "text": [ "east 110", "g), b" ], "offsets": [ [ 584, 592 ], [ 605, 610 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T22", "type": "Scope", "text": [ "at least 110 pounds (50 kg)" ], "offsets": [ [ 580, 607 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T23", "type": "Condition", "text": [ "obesity" ], "offsets": [ [ 628, 635 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T24", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 637, 640 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T25", "type": "Negation", "text": [ "not to present" ], "offsets": [ [ 613, 627 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T26", "type": "Value", "text": [ "< 32kg/m2" ], "offsets": [ [ 641, 650 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T27", "type": "Person", "text": [ "Female" ], "offsets": [ [ 653, 659 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T28", "type": "Negation", "text": [ "non-" ], "offsets": [ [ 672, 676 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T29", "type": "Observation", "text": [ "childbearing potential" ], "offsets": [ [ 676, 698 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T30", "type": "Observation", "text": [ "pre-menarche" ], "offsets": [ [ 770, 782 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T31", "type": "Scope", "text": [ "BMI < 32kg/m2" ], "offsets": [ [ 637, 650 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T32", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 784, 791 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T33", "type": "Condition", "text": [ "bilateral tubal ligation" ], "offsets": [ [ 792, 816 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T34", "type": "Condition", "text": [ "eral tubal liga", "sion, hys" ], "offsets": [ [ 797, 812 ], [ 825, 834 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T35", "type": "Scope", "text": [ "bilateral tubal ligation or occlusion" ], "offsets": [ [ 792, 829 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T36", "type": "Condition", "text": [ "hysterectomy" ], "offsets": [ [ 831, 843 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T37", "type": "Procedure", "text": [ "bilateral tubal ligation" ], "offsets": [ [ 792, 816 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T38", "type": "Procedure", "text": [ "eral tubal liga", "sion, hys" ], "offsets": [ [ 797, 812 ], [ 825, 834 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T39", "type": "Condition", "text": [ "bilateral ovariectomy" ], "offsets": [ [ 845, 866 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T40", "type": "Observation", "text": [ "post-menopause" ], "offsets": [ [ 870, 884 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T42", "type": "Procedure", "text": [ "bilateral ovariectomy" ], "offsets": [ [ 845, 866 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T41", "type": "Scope", "text": [ "pre-menarche, current bilateral tubal ligation or occlusion, hysterectomy, bilateral ovariectomy or post-menopause" ], "offsets": [ [ 770, 884 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T43", "type": "Scope", "text": [ "non-childbearing potential" ], "offsets": [ [ 672, 698 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T44", "type": "Scope", "text": [ "pre-menarche, current bilateral tubal ligation or occlusion, hysterectomy, bilateral ovariectomy or post-menopause" ], "offsets": [ [ 770, 884 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T45", "type": "Observation", "text": [ "contraception" ], "offsets": [ [ 909, 922 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T46", "type": "Qualifier", "text": [ "adequate" ], "offsets": [ [ 900, 908 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T47", "type": "Temporal", "text": [ "30 days prior to vaccination" ], "offsets": [ [ 927, 955 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T48", "type": "Reference_point", "text": [ "vaccination" ], "offsets": [ [ 944, 955 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T49", "type": "Value", "text": [ "negative" ], "offsets": [ [ 967, 975 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T50", "type": "Measurement", "text": [ "pregnancy test" ], "offsets": [ [ 976, 990 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T51", "type": "Temporal", "text": [ "on the day of vaccination" ], "offsets": [ [ 991, 1016 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T52", "type": "Reference_point", "text": [ "vaccination" ], "offsets": [ [ 1005, 1016 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T53", "type": "Multiplier", "text": [ "continue" ], "offsets": [ [ 1035, 1043 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T54", "type": "Observation", "text": [ "adequate contraception" ], "offsets": [ [ 1044, 1066 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T55", "type": "Temporal", "text": [ "during the entire treatment period" ], "offsets": [ [ 1067, 1101 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T56", "type": "Temporal", "text": [ "for 1 month, after completion of the vaccination series" ], "offsets": [ [ 1106, 1161 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T57", "type": "Reference_point", "text": [ "completion of the vaccination series" ], "offsets": [ [ 1125, 1161 ] ], "normalized": [] }, { "id": "NCT03493919_inc_T58", "type": "Scope", "text": [ "during the entire treatment period and for 1 month, after completion of the vaccination series" ], "offsets": [ [ 1067, 1161 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03493919_inc_R1", "type": "Has_index", "arg1_id": "NCT03493919_inc_T5", "arg2_id": "NCT03493919_inc_T6", "normalized": [] }, { "id": "NCT03493919_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03493919_inc_T3", "arg2_id": "NCT03493919_inc_T5", "normalized": [] }, { "id": "NCT03493919_inc_R4", "type": "Has_value", "arg1_id": "NCT03493919_inc_T10", "arg2_id": "NCT03493919_inc_T9", "normalized": [] }, { "id": "NCT03493919_inc_R5", "type": "Has_index", "arg1_id": "NCT03493919_inc_T11", "arg2_id": "NCT03493919_inc_T12", "normalized": [] }, { "id": "NCT03493919_inc_R6", "type": "Has_temporal", "arg1_id": "NCT03493919_inc_T10", "arg2_id": "NCT03493919_inc_T11", "normalized": [] }, { "id": "NCT03493919_inc_R7", "type": "Has_index", "arg1_id": "NCT03493919_inc_T16", "arg2_id": "NCT03493919_inc_T17", "normalized": [] }, { "id": "NCT03493919_inc_R8", "type": "Has_temporal", "arg1_id": "NCT03493919_inc_T13", "arg2_id": "NCT03493919_inc_T16", "normalized": [] }, { "id": "NCT03493919_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03493919_inc_T13", "arg2_id": "NCT03493919_inc_T14", "normalized": [] }, { "id": "NCT03493919_inc_R10", "type": "AND", "arg1_id": "NCT03493919_inc_T13", "arg2_id": "NCT03493919_inc_T15", "normalized": [] }, { "id": "NCT03493919_inc_R11", "type": "Subsumes", "arg1_id": "NCT03493919_inc_T20", "arg2_id": "NCT03493919_inc_T21", "normalized": [] }, { "id": "NCT03493919_inc_R12", "type": "Has_scope", "arg1_id": "NCT03493919_inc_T19", "arg2_id": "NCT03493919_inc_T22", "normalized": [] }, { "id": "NCT03493919_inc_R13", "type": "Has_negation", "arg1_id": "NCT03493919_inc_T23", "arg2_id": "NCT03493919_inc_T25", "normalized": [] }, { "id": "NCT03493919_inc_R14", "type": "Has_value", "arg1_id": "NCT03493919_inc_T24", "arg2_id": "NCT03493919_inc_T26", "normalized": [] }, { "id": "NCT03493919_inc_R15", "type": "Has_negation", "arg1_id": "NCT03493919_inc_T29", "arg2_id": "NCT03493919_inc_T28", "normalized": [] }, { "id": "NCT03493919_inc_R16", "type": "Subsumes", "arg1_id": "NCT03493919_inc_T23", "arg2_id": "NCT03493919_inc_T31", "normalized": [] }, { "id": "NCT03493919_inc_R17", "type": "Has_temporal", "arg1_id": "NCT03493919_inc_T35", "arg2_id": "NCT03493919_inc_T32", "normalized": [] }, { "id": "NCT03493919_inc_R21", "type": "Subsumes", "arg1_id": "NCT03493919_inc_T43", "arg2_id": "NCT03493919_inc_T44", "normalized": [] }, { "id": "NCT03493919_inc_R22", "type": "Has_qualifier", "arg1_id": "NCT03493919_inc_T45", "arg2_id": "NCT03493919_inc_T46", "normalized": [] }, { "id": "NCT03493919_inc_R23", "type": "Has_temporal", "arg1_id": "NCT03493919_inc_T45", "arg2_id": "NCT03493919_inc_T47", "normalized": [] }, { "id": "NCT03493919_inc_R24", "type": "Has_index", "arg1_id": "NCT03493919_inc_T47", "arg2_id": "NCT03493919_inc_T48", "normalized": [] }, { "id": "NCT03493919_inc_R25", "type": "Has_value", "arg1_id": "NCT03493919_inc_T50", "arg2_id": "NCT03493919_inc_T49", "normalized": [] }, { "id": "NCT03493919_inc_R26", "type": "Has_index", "arg1_id": "NCT03493919_inc_T51", "arg2_id": "NCT03493919_inc_T52", "normalized": [] }, { "id": "NCT03493919_inc_R27", "type": "Has_temporal", "arg1_id": "NCT03493919_inc_T50", "arg2_id": "NCT03493919_inc_T51", "normalized": [] }, { "id": "NCT03493919_inc_R28", "type": "Has_index", "arg1_id": "NCT03493919_inc_T56", "arg2_id": "NCT03493919_inc_T57", "normalized": [] }, { "id": "NCT03493919_inc_R29", "type": "Has_multiplier", "arg1_id": "NCT03493919_inc_T54", "arg2_id": "NCT03493919_inc_T53", "normalized": [] }, { "id": "NCT03493919_inc_R30", "type": "Has_scope", "arg1_id": "NCT03493919_inc_T54", "arg2_id": "NCT03493919_inc_T58", "normalized": [] } ]

[ { "id": "NCT03495557_exc_text", "type": "exclusion", "text": [ "Conversion to laparotomy\nEmergent re intervention\nImmunosuppression\nUmbilical hernia\n" ], "offsets": [ [ 0, 85 ] ] } ]

[ { "id": "NCT03495557_exc_T1", "type": "Observation", "text": [ "Conversion to" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03495557_exc_T2", "type": "Procedure", "text": [ "laparotomy" ], "offsets": [ [ 14, 24 ] ], "normalized": [] }, { "id": "NCT03495557_exc_T3", "type": "Procedure", "text": [ "re intervention" ], "offsets": [ [ 34, 49 ] ], "normalized": [] }, { "id": "NCT03495557_exc_T4", "type": "Qualifier", "text": [ "Emergent" ], "offsets": [ [ 25, 33 ] ], "normalized": [] }, { "id": "NCT03495557_exc_T5", "type": "Condition", "text": [ "Immunosuppression" ], "offsets": [ [ 50, 67 ] ], "normalized": [] }, { "id": "NCT03495557_exc_T6", "type": "Condition", "text": [ "Umbilical hernia" ], "offsets": [ [ 68, 84 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03495557_exc_R1", "type": "AND", "arg1_id": "NCT03495557_exc_T1", "arg2_id": "NCT03495557_exc_T2", "normalized": [] }, { "id": "NCT03495557_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03495557_exc_T3", "arg2_id": "NCT03495557_exc_T4", "normalized": [] } ]

[ { "id": "NCT03495557_inc_text", "type": "inclusion", "text": [ "Age = 18 years\nLaparoscopic cholecystectomy\nEmergent/elective\n=2 risk factors: diabetes mellitus, age =70 years, BMI =30, fascial enlargement\n" ], "offsets": [ [ 0, 142 ] ] } ]

[ { "id": "NCT03495557_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T2", "type": "Value", "text": [ "= 18 years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T3", "type": "Procedure", "text": [ "cholecystectomy" ], "offsets": [ [ 28, 43 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T4", "type": "Qualifier", "text": [ "Laparoscopic" ], "offsets": [ [ 15, 27 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T5", "type": "Qualifier", "text": [ "Emergent" ], "offsets": [ [ 44, 52 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T6", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 53, 61 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T7", "type": "Multiplier", "text": [ "=2" ], "offsets": [ [ 62, 64 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T8", "type": "Condition", "text": [ "risk factors" ], "offsets": [ [ 65, 77 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T9", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 79, 96 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T10", "type": "Person", "text": [ "age" ], "offsets": [ [ 98, 101 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T11", "type": "Value", "text": [ "=70 years" ], "offsets": [ [ 102, 111 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T12", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 113, 116 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T13", "type": "Value", "text": [ "=30" ], "offsets": [ [ 117, 120 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T14", "type": "Condition", "text": [ "fascial enlargement" ], "offsets": [ [ 122, 141 ] ], "normalized": [] }, { "id": "NCT03495557_inc_T15", "type": "Scope", "text": [ "diabetes mellitus, age =70 years, BMI =30, fascial enlargement" ], "offsets": [ [ 79, 141 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03495557_inc_R1", "type": "Has_value", "arg1_id": "NCT03495557_inc_T1", "arg2_id": "NCT03495557_inc_T2", "normalized": [] }, { "id": "NCT03495557_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03495557_inc_T3", "arg2_id": "NCT03495557_inc_T4", "normalized": [] }, { "id": "NCT03495557_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT03495557_inc_T8", "arg2_id": "NCT03495557_inc_T7", "normalized": [] }, { "id": "NCT03495557_inc_R4", "type": "Has_value", "arg1_id": "NCT03495557_inc_T10", "arg2_id": "NCT03495557_inc_T11", "normalized": [] }, { "id": "NCT03495557_inc_R5", "type": "Has_value", "arg1_id": "NCT03495557_inc_T12", "arg2_id": "NCT03495557_inc_T13", "normalized": [] }, { "id": "NCT03495557_inc_R6", "type": "Subsumes", "arg1_id": "NCT03495557_inc_T8", "arg2_id": "NCT03495557_inc_T15", "normalized": [] } ]

[ { "id": "NCT03495609_exc_text", "type": "exclusion", "text": [ "History of allergic reaction to compounds of similar chemical or biologic composition to hCG\nreceiving medication that could interfere with the study protocol objectives (hormonal contraceptives, androgens, prednisone, thyroid hormones, insulin)\nprevious treatment with follicle stimulating hormone for assisted reproduction\nuncontrolled intercurrent illness\nHeart disease\nSevere cognitive decline\nPsychiatric desease\nHIV positive\nHepatitis B or C infection\n" ], "offsets": [ [ 0, 458 ] ] } ]

[ { "id": "NCT03495609_exc_T1", "type": "Observation", "text": [ "History" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T2", "type": "Condition", "text": [ "allergic reaction" ], "offsets": [ [ 11, 28 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T3", "type": "Drug", "text": [ "compounds of similar chemical or biologic composition to hCG" ], "offsets": [ [ 32, 92 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T4", "type": "Drug", "text": [ "hCG" ], "offsets": [ [ 89, 92 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T5", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 103, 113 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T6", "type": "Qualifier", "text": [ "could interfere with the study protocol objectives" ], "offsets": [ [ 119, 169 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T7", "type": "Drug", "text": [ "hormonal contraceptives" ], "offsets": [ [ 171, 194 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T8", "type": "Drug", "text": [ "androgens" ], "offsets": [ [ 196, 205 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T9", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 207, 217 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T10", "type": "Drug", "text": [ "thyroid hormones" ], "offsets": [ [ 219, 235 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T11", "type": "Drug", "text": [ "insulin" ], "offsets": [ [ 237, 244 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T12", "type": "Scope", "text": [ "hormonal contraceptives, androgens, prednisone, thyroid hormones, insulin" ], "offsets": [ [ 171, 244 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T13", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 246, 254 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T14", "type": "Temporal", "text": [ "receiving" ], "offsets": [ [ 93, 102 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T15", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 255, 264 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T16", "type": "Drug", "text": [ "follicle stimulating hormone" ], "offsets": [ [ 270, 298 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T17", "type": "Procedure", "text": [ "assisted reproduction" ], "offsets": [ [ 303, 324 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T18", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 325, 337 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T19", "type": "Condition", "text": [ "intercurrent illness" ], "offsets": [ [ 338, 358 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T20", "type": "Condition", "text": [ "Heart disease" ], "offsets": [ [ 359, 372 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T21", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 373, 379 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T22", "type": "Condition", "text": [ "cognitive decline" ], "offsets": [ [ 380, 397 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T23", "type": "Condition", "text": [ "Psychiatric desease" ], "offsets": [ [ 398, 417 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T24", "type": "Condition", "text": [ "HIV positive" ], "offsets": [ [ 418, 430 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T25", "type": "Condition", "text": [ "s B or C in", "n" ], "offsets": [ [ 439, 450 ], [ 456, 457 ] ], "normalized": [] }, { "id": "NCT03495609_exc_T26", "type": "Condition", "text": [ "s B or C", "ion" ], "offsets": [ [ 439, 447 ], [ 454, 457 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03495609_exc_R2", "type": "AND", "arg1_id": "NCT03495609_exc_T2", "arg2_id": "NCT03495609_exc_T3", "normalized": [] }, { "id": "NCT03495609_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03495609_exc_T2", "arg2_id": "NCT03495609_exc_T1", "normalized": [] }, { "id": "NCT03495609_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03495609_exc_T5", "arg2_id": "NCT03495609_exc_T6", "normalized": [] }, { "id": "NCT03495609_exc_R5", "type": "Subsumes", "arg1_id": "NCT03495609_exc_T5", "arg2_id": "NCT03495609_exc_T12", "normalized": [] }, { "id": "NCT03495609_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03495609_exc_T5", "arg2_id": "NCT03495609_exc_T14", "normalized": [] }, { "id": "NCT03495609_exc_R7", "type": "AND", "arg1_id": "NCT03495609_exc_T15", "arg2_id": "NCT03495609_exc_T16", "normalized": [] }, { "id": "NCT03495609_exc_R8", "type": "AND", "arg1_id": "NCT03495609_exc_T15", "arg2_id": "NCT03495609_exc_T17", "normalized": [] }, { "id": "NCT03495609_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03495609_exc_T15", "arg2_id": "NCT03495609_exc_T13", "normalized": [] }, { "id": "NCT03495609_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03495609_exc_T19", "arg2_id": "NCT03495609_exc_T18", "normalized": [] }, { "id": "NCT03495609_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03495609_exc_T22", "arg2_id": "NCT03495609_exc_T21", "normalized": [] } ]

[ { "id": "NCT03495609_inc_text", "type": "inclusion", "text": [ "premenopausal women\nBRCA1 carrier\n" ], "offsets": [ [ 0, 34 ] ] } ]

[ { "id": "NCT03495609_inc_T1", "type": "Condition", "text": [ "premenopausal" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03495609_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 14, 19 ] ], "normalized": [] }, { "id": "NCT03495609_inc_T3", "type": "Condition", "text": [ "BRCA1 carrier" ], "offsets": [ [ 20, 33 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT03497598_exc_text", "type": "exclusion", "text": [ "UTIs = 12 within 1 year\nPregnancy or Lactation\nImmune disease\nLactose intolerance\nUrinary tract anomaly\nSystemic infection\nNewly started hormone therapy within the last 6 months\nAntibiotic prophylaxis within the last 6 months\na-D-mannose intake within the last month\nUse of catheters\nDiabetes mellitus\nParticipation to other studies\n" ], "offsets": [ [ 0, 333 ] ] } ]

[ { "id": "NCT03497598_exc_T1", "type": "Condition", "text": [ "UTIs" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T2", "type": "Multiplier", "text": [ "12 within 1 year" ], "offsets": [ [ 7, 23 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T3", "type": "Temporal", "text": [ "within 1 year" ], "offsets": [ [ 10, 23 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T4", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 24, 33 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T5", "type": "Condition", "text": [ "Lactation" ], "offsets": [ [ 37, 46 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T6", "type": "Condition", "text": [ "Immune disease" ], "offsets": [ [ 47, 61 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T7", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 70, 81 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T8", "type": "Drug", "text": [ "Lactose" ], "offsets": [ [ 62, 69 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T9", "type": "Condition", "text": [ "Lactose intolerance" ], "offsets": [ [ 62, 81 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T10", "type": "Condition", "text": [ "Urinary tract anomaly" ], "offsets": [ [ 82, 103 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T11", "type": "Condition", "text": [ "Systemic infection" ], "offsets": [ [ 104, 122 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T12", "type": "Multiplier", "text": [ "Newly started" ], "offsets": [ [ 123, 136 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T13", "type": "Procedure", "text": [ "hormone therapy" ], "offsets": [ [ 137, 152 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T14", "type": "Temporal", "text": [ "within the last 6 months" ], "offsets": [ [ 153, 177 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T16", "type": "Procedure", "text": [ "Antibiotic prophylaxis" ], "offsets": [ [ 178, 200 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T17", "type": "Temporal", "text": [ "within the last 6 months" ], "offsets": [ [ 201, 225 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T15", "type": "Drug", "text": [ "Antibiotic" ], "offsets": [ [ 178, 188 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T18", "type": "Drug", "text": [ "a-D-mannose" ], "offsets": [ [ 226, 237 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T19", "type": "Temporal", "text": [ "within the last month" ], "offsets": [ [ 245, 266 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T20", "type": "Device", "text": [ "catheters" ], "offsets": [ [ 274, 283 ] ], "normalized": [] }, { "id": "NCT03497598_exc_T21", "type": "Condition", "text": [ "Diabetes mellitus" ], "offsets": [ [ 284, 301 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03497598_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT03497598_exc_T1", "arg2_id": "NCT03497598_exc_T2", "normalized": [] }, { "id": "NCT03497598_exc_R3", "type": "AND", "arg1_id": "NCT03497598_exc_T7", "arg2_id": "NCT03497598_exc_T8", "normalized": [] }, { "id": "NCT03497598_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03497598_exc_T13", "arg2_id": "NCT03497598_exc_T14", "normalized": [] }, { "id": "NCT03497598_exc_R6", "type": "Has_multiplier", "arg1_id": "NCT03497598_exc_T13", "arg2_id": "NCT03497598_exc_T12", "normalized": [] }, { "id": "NCT03497598_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03497598_exc_T16", "arg2_id": "NCT03497598_exc_T17", "normalized": [] }, { "id": "NCT03497598_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03497598_exc_T18", "arg2_id": "NCT03497598_exc_T19", "normalized": [] } ]

[ { "id": "NCT03497598_inc_text", "type": "inclusion", "text": [ "Women\n= 3 UTIs within the last 12 months or = 2 UTIs within the last 6 months;\nLaboratory urine culture: <103 CFUs\nAge > 18 years\n" ], "offsets": [ [ 0, 130 ] ] } ]

[ { "id": "NCT03497598_inc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T2", "type": "Condition", "text": [ "UTIs" ], "offsets": [ [ 10, 14 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T3", "type": "Multiplier", "text": [ "= 3" ], "offsets": [ [ 6, 9 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T4", "type": "Temporal", "text": [ "within the last 12 months" ], "offsets": [ [ 15, 40 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T5", "type": "Multiplier", "text": [ "= 2" ], "offsets": [ [ 44, 47 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T6", "type": "Condition", "text": [ "UTIs" ], "offsets": [ [ 48, 52 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T7", "type": "Temporal", "text": [ "within the last 6 months" ], "offsets": [ [ 53, 77 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T8", "type": "Measurement", "text": [ "Laboratory urine culture" ], "offsets": [ [ 79, 103 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T9", "type": "Value", "text": [ "<103 CFUs" ], "offsets": [ [ 105, 114 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T10", "type": "Person", "text": [ "Age" ], "offsets": [ [ 115, 118 ] ], "normalized": [] }, { "id": "NCT03497598_inc_T11", "type": "Value", "text": [ "> 18 years" ], "offsets": [ [ 119, 129 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03497598_inc_R1", "type": "Has_multiplier", "arg1_id": "NCT03497598_inc_T2", "arg2_id": "NCT03497598_inc_T3", "normalized": [] }, { "id": "NCT03497598_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT03497598_inc_T6", "arg2_id": "NCT03497598_inc_T5", "normalized": [] }, { "id": "NCT03497598_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03497598_inc_T6", "arg2_id": "NCT03497598_inc_T7", "normalized": [] }, { "id": "NCT03497598_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03497598_inc_T2", "arg2_id": "NCT03497598_inc_T4", "normalized": [] }, { "id": "NCT03497598_inc_R5", "type": "Has_value", "arg1_id": "NCT03497598_inc_T8", "arg2_id": "NCT03497598_inc_T9", "normalized": [] }, { "id": "NCT03497598_inc_R6", "type": "Has_value", "arg1_id": "NCT03497598_inc_T10", "arg2_id": "NCT03497598_inc_T11", "normalized": [] } ]

[ { "id": "NCT03499639_exc_text", "type": "exclusion", "text": [ "Patients with combined HCV/HBV co-infection\nhepatocellular carcinoma (HCC)\ndecompensated liver cirrhosis (Child-Pugh score above 6)\nnon-genotype 4\n" ], "offsets": [ [ 0, 147 ] ] } ]

[ { "id": "NCT03499639_exc_T1", "type": "Condition", "text": [ "HCV", "infection" ], "offsets": [ [ 23, 26 ], [ 34, 43 ] ], "normalized": [] }, { "id": "NCT03499639_exc_T2", "type": "Condition", "text": [ "HBV", "infection" ], "offsets": [ [ 27, 30 ], [ 34, 43 ] ], "normalized": [] }, { "id": "NCT03499639_exc_T3", "type": "Condition", "text": [ "hepatocellular carcinoma (HCC)" ], "offsets": [ [ 44, 74 ] ], "normalized": [] }, { "id": "NCT03499639_exc_T4", "type": "Condition", "text": [ "liver cirrhosis" ], "offsets": [ [ 89, 104 ] ], "normalized": [] }, { "id": "NCT03499639_exc_T5", "type": "Qualifier", "text": [ "decompensated" ], "offsets": [ [ 75, 88 ] ], "normalized": [] }, { "id": "NCT03499639_exc_T6", "type": "Measurement", "text": [ "Child-Pugh score" ], "offsets": [ [ 106, 122 ] ], "normalized": [] }, { "id": "NCT03499639_exc_T7", "type": "Value", "text": [ "above 6" ], "offsets": [ [ 123, 130 ] ], "normalized": [] }, { "id": "NCT03499639_exc_T8", "type": "Condition", "text": [ "genotype 4" ], "offsets": [ [ 136, 146 ] ], "normalized": [] }, { "id": "NCT03499639_exc_T9", "type": "Negation", "text": [ "non" ], "offsets": [ [ 132, 135 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03499639_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03499639_exc_T4", "arg2_id": "NCT03499639_exc_T5", "normalized": [] }, { "id": "NCT03499639_exc_R2", "type": "Has_value", "arg1_id": "NCT03499639_exc_T6", "arg2_id": "NCT03499639_exc_T7", "normalized": [] }, { "id": "NCT03499639_exc_R3", "type": "Subsumes", "arg1_id": "NCT03499639_exc_T5", "arg2_id": "NCT03499639_exc_T6", "normalized": [] }, { "id": "NCT03499639_exc_R4", "type": "Has_negation", "arg1_id": "NCT03499639_exc_T8", "arg2_id": "NCT03499639_exc_T9", "normalized": [] } ]

[ { "id": "NCT03499639_inc_text", "type": "inclusion", "text": [ "patients were 18 years old or more,\nnaive to HCV treatment,\nHCV genotype 4,\ncompensated liver disease.\n" ], "offsets": [ [ 0, 103 ] ] } ]

[ { "id": "NCT03499639_inc_T1", "type": "Value", "text": [ "18 years old or more" ], "offsets": [ [ 14, 34 ] ], "normalized": [] }, { "id": "NCT03499639_inc_T2", "type": "Person", "text": [ "old" ], "offsets": [ [ 23, 26 ] ], "normalized": [] }, { "id": "NCT03499639_inc_T3", "type": "Procedure", "text": [ "HCV treatment" ], "offsets": [ [ 45, 58 ] ], "normalized": [] }, { "id": "NCT03499639_inc_T4", "type": "Negation", "text": [ "naive" ], "offsets": [ [ 36, 41 ] ], "normalized": [] }, { "id": "NCT03499639_inc_T5", "type": "Measurement", "text": [ "HCV genotype" ], "offsets": [ [ 60, 72 ] ], "normalized": [] }, { "id": "NCT03499639_inc_T6", "type": "Value", "text": [ "4" ], "offsets": [ [ 73, 74 ] ], "normalized": [] }, { "id": "NCT03499639_inc_T7", "type": "Qualifier", "text": [ "compensated" ], "offsets": [ [ 76, 87 ] ], "normalized": [] }, { "id": "NCT03499639_inc_T8", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 88, 101 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03499639_inc_R1", "type": "Has_value", "arg1_id": "NCT03499639_inc_T2", "arg2_id": "NCT03499639_inc_T1", "normalized": [] }, { "id": "NCT03499639_inc_R2", "type": "Has_negation", "arg1_id": "NCT03499639_inc_T3", "arg2_id": "NCT03499639_inc_T4", "normalized": [] }, { "id": "NCT03499639_inc_R3", "type": "Has_value", "arg1_id": "NCT03499639_inc_T5", "arg2_id": "NCT03499639_inc_T6", "normalized": [] }, { "id": "NCT03499639_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03499639_inc_T8", "arg2_id": "NCT03499639_inc_T7", "normalized": [] } ]

[ { "id": "NCT03500211_exc_text", "type": "exclusion", "text": [ "Patients requiring emergent cesarean birth\nPatients allergic to lidocaine or adhesive\nPatients who have already received an epidural during this admission or requiring general anesthesia for cesarean birth\nPatients using chronic oral neuromodulators\nPatients with cardiac disease or using anti-arrhythmic agents\nPatients with fibromyalgia or chronic pain syndromes such as rheumatoid arthritis, osteoarthritis, or lupus.\nDaily narcotic or opiate use for greater than the 2 months prior to enrollment in the study.\n" ], "offsets": [ [ 0, 514 ] ] } ]

[ { "id": "NCT03500211_exc_T1", "type": "Procedure", "text": [ "emergent cesarean birth" ], "offsets": [ [ 19, 42 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T2", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 52, 60 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T3", "type": "Drug", "text": [ "lidocaine" ], "offsets": [ [ 64, 73 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T4", "type": "Drug", "text": [ "adhesive" ], "offsets": [ [ 77, 85 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T5", "type": "Scope", "text": [ "lidocaine or adhesive" ], "offsets": [ [ 64, 85 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T6", "type": "Procedure", "text": [ "epidural" ], "offsets": [ [ 124, 132 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T7", "type": "Temporal", "text": [ "during this admission" ], "offsets": [ [ 133, 154 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T8", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 158, 167 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T9", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 168, 186 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T10", "type": "Procedure", "text": [ "cesarean birth" ], "offsets": [ [ 191, 205 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T11", "type": "Drug", "text": [ "chronic oral neuromodulators" ], "offsets": [ [ 221, 249 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T12", "type": "Drug", "text": [ "anti-arrhythmic agents" ], "offsets": [ [ 289, 311 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T13", "type": "Condition", "text": [ "cardiac disease" ], "offsets": [ [ 264, 279 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T14", "type": "Condition", "text": [ "fibromyalgia" ], "offsets": [ [ 326, 338 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T15", "type": "Condition", "text": [ "chronic pain syndromes" ], "offsets": [ [ 342, 364 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T16", "type": "Condition", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 373, 393 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T17", "type": "Condition", "text": [ "osteoarthritis" ], "offsets": [ [ 395, 409 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T18", "type": "Condition", "text": [ "lupus" ], "offsets": [ [ 414, 419 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T19", "type": "Scope", "text": [ "rheumatoid arthritis, osteoarthritis, or lupus" ], "offsets": [ [ 373, 419 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T20", "type": "Drug", "text": [ "narcotic" ], "offsets": [ [ 427, 435 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T21", "type": "Multiplier", "text": [ "Daily" ], "offsets": [ [ 421, 426 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T22", "type": "Drug", "text": [ "opiate" ], "offsets": [ [ 439, 445 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T23", "type": "Temporal", "text": [ "for greater than the 2 months prior to enrollment in the study" ], "offsets": [ [ 450, 512 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T24", "type": "Reference_point", "text": [ "enrollment in the study" ], "offsets": [ [ 489, 512 ] ], "normalized": [] }, { "id": "NCT03500211_exc_T25", "type": "Scope", "text": [ "narcotic or opiate" ], "offsets": [ [ 427, 445 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03500211_exc_R1", "type": "Has_scope", "arg1_id": "NCT03500211_exc_T2", "arg2_id": "NCT03500211_exc_T5", "normalized": [] }, { "id": "NCT03500211_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03500211_exc_T6", "arg2_id": "NCT03500211_exc_T7", "normalized": [] }, { "id": "NCT03500211_exc_R3", "type": "Has_mood", "arg1_id": "NCT03500211_exc_T9", "arg2_id": "NCT03500211_exc_T8", "normalized": [] }, { "id": "NCT03500211_exc_R4", "type": "AND", "arg1_id": "NCT03500211_exc_T9", "arg2_id": "NCT03500211_exc_T10", "normalized": [] }, { "id": "NCT03500211_exc_R5", "type": "Subsumes", "arg1_id": "NCT03500211_exc_T15", "arg2_id": "NCT03500211_exc_T19", "normalized": [] }, { "id": "NCT03500211_exc_R6", "type": "Has_index", "arg1_id": "NCT03500211_exc_T23", "arg2_id": "NCT03500211_exc_T24", "normalized": [] }, { "id": "NCT03500211_exc_R7", "type": "Has_multiplier", "arg1_id": "NCT03500211_exc_T25", "arg2_id": "NCT03500211_exc_T21", "normalized": [] }, { "id": "NCT03500211_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03500211_exc_T25", "arg2_id": "NCT03500211_exc_T23", "normalized": [] } ]

[ { "id": "NCT03500211_inc_text", "type": "inclusion", "text": [ "Pregnant patients who require a scheduled or non-urgent cesarean birth\nPatient able to receive neuraxial analgesia\nPatient able to give verbal and written consent for both cesarean birth and study\n" ], "offsets": [ [ 0, 197 ] ] } ]

[ { "id": "NCT03500211_inc_T1", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03500211_inc_T2", "type": "Qualifier", "text": [ "scheduled" ], "offsets": [ [ 32, 41 ] ], "normalized": [] }, { "id": "NCT03500211_inc_T3", "type": "Qualifier", "text": [ "non-urgent" ], "offsets": [ [ 45, 55 ] ], "normalized": [] }, { "id": "NCT03500211_inc_T4", "type": "Procedure", "text": [ "cesarean birth" ], "offsets": [ [ 56, 70 ] ], "normalized": [] }, { "id": "NCT03500211_inc_T5", "type": "Scope", "text": [ "scheduled or non-urgent" ], "offsets": [ [ 32, 55 ] ], "normalized": [] }, { "id": "NCT03500211_inc_T6", "type": "Procedure", "text": [ "neuraxial analgesia" ], "offsets": [ [ 95, 114 ] ], "normalized": [] }, { "id": "NCT03500211_inc_T7", "type": "Mood", "text": [ "able to receive" ], "offsets": [ [ 79, 94 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03500211_inc_R1", "type": "Has_scope", "arg1_id": "NCT03500211_inc_T4", "arg2_id": "NCT03500211_inc_T5", "normalized": [] }, { "id": "NCT03500211_inc_R2", "type": "Has_mood", "arg1_id": "NCT03500211_inc_T6", "arg2_id": "NCT03500211_inc_T7", "normalized": [] } ]

[ { "id": "NCT03506009_exc_text", "type": "exclusion", "text": [ "mRS=2;\nHistory of stroke within 3 months;\nHistory of intracranial hemorrhage;\nSuspected subarachnoid hemorrhage;\nIntracranial tumour, vascular malformation or arterial aneurysm;\nMajor surgery within 1 month;\nSystolic pressure =180 mmHg or diastolic pressure =110 mmHg;\nPlatelet count < 105/mm3;\nHeparin therapy or oral anticoagulation therapy within 48 hours;\nAbnormal APTT;\nThrombin or Xa factor inhibitor;\nSevere disease with a life expectancy of less than 3 months;\nBlood glucose < 50 mg/dL (2.7mmol/L);\nPatients who have received any other investigational drug or device within 3 months;\nPregnancy;\nResearchers consider patients inappropriate to participate in the registry.\n" ], "offsets": [ [ 0, 679 ] ] } ]

[ { "id": "NCT03506009_exc_T1", "type": "Measurement", "text": [ "mRS" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T2", "type": "Value", "text": [ "=2" ], "offsets": [ [ 3, 5 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T3", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 18, 24 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T4", "type": "Value", "text": [ "within 3 months" ], "offsets": [ [ 25, 40 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T5", "type": "Condition", "text": [ "intracranial hemorrhage" ], "offsets": [ [ 53, 76 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T6", "type": "Condition", "text": [ "subarachnoid hemorrhage" ], "offsets": [ [ 88, 111 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T7", "type": "Condition", "text": [ "Intracranial tumour" ], "offsets": [ [ 113, 132 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T8", "type": "Condition", "text": [ "vascular malformation" ], "offsets": [ [ 134, 155 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T9", "type": "Condition", "text": [ "arterial aneurysm" ], "offsets": [ [ 159, 176 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T10", "type": "Procedure", "text": [ "Major surgery" ], "offsets": [ [ 178, 191 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T11", "type": "Value", "text": [ "within 1 month" ], "offsets": [ [ 192, 206 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T12", "type": "Measurement", "text": [ "Systolic pressure" ], "offsets": [ [ 208, 225 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T13", "type": "Value", "text": [ "=180 mmHg" ], "offsets": [ [ 226, 235 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T14", "type": "Measurement", "text": [ "diastolic pressure" ], "offsets": [ [ 239, 257 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T15", "type": "Value", "text": [ "=110 mmHg" ], "offsets": [ [ 258, 267 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T16", "type": "Measurement", "text": [ "Platelet count" ], "offsets": [ [ 269, 283 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T17", "type": "Value", "text": [ "< 105/mm3" ], "offsets": [ [ 284, 293 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T18", "type": "Drug", "text": [ "Heparin" ], "offsets": [ [ 295, 302 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T19", "type": "Procedure", "text": [ "therapy" ], "offsets": [ [ 303, 310 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T20", "type": "Procedure", "text": [ "oral anticoagulation therapy" ], "offsets": [ [ 314, 342 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T21", "type": "Temporal", "text": [ "within 48 hours" ], "offsets": [ [ 343, 358 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T22", "type": "Scope", "text": [ "Heparin therapy or oral anticoagulation therapy" ], "offsets": [ [ 295, 342 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T23", "type": "Value", "text": [ "Abnormal" ], "offsets": [ [ 360, 368 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T24", "type": "Measurement", "text": [ "APTT" ], "offsets": [ [ 369, 373 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T25", "type": "Drug", "text": [ "Thrombin" ], "offsets": [ [ 375, 383 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T26", "type": "Drug", "text": [ "Xa factor inhibitor" ], "offsets": [ [ 387, 406 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T27", "type": "Observation", "text": [ "life expectancy" ], "offsets": [ [ 430, 445 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T28", "type": "Value", "text": [ "less than 3 months" ], "offsets": [ [ 449, 467 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T29", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 415, 422 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T30", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 408, 414 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T31", "type": "Measurement", "text": [ "Blood glucose" ], "offsets": [ [ 469, 482 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T32", "type": "Value", "text": [ "< 50 mg/dL" ], "offsets": [ [ 483, 493 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T33", "type": "Value", "text": [ "2.7mmol/L" ], "offsets": [ [ 495, 504 ] ], "normalized": [] }, { "id": "NCT03506009_exc_T35", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 592, 601 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03506009_exc_R1", "type": "Has_value", "arg1_id": "NCT03506009_exc_T1", "arg2_id": "NCT03506009_exc_T2", "normalized": [] }, { "id": "NCT03506009_exc_R2", "type": "Has_value", "arg1_id": "NCT03506009_exc_T3", "arg2_id": "NCT03506009_exc_T4", "normalized": [] }, { "id": "NCT03506009_exc_R3", "type": "Has_value", "arg1_id": "NCT03506009_exc_T10", "arg2_id": "NCT03506009_exc_T11", "normalized": [] }, { "id": "NCT03506009_exc_R4", "type": "Has_value", "arg1_id": "NCT03506009_exc_T14", "arg2_id": "NCT03506009_exc_T15", "normalized": [] }, { "id": "NCT03506009_exc_R5", "type": "Has_value", "arg1_id": "NCT03506009_exc_T12", "arg2_id": "NCT03506009_exc_T13", "normalized": [] }, { "id": "NCT03506009_exc_R6", "type": "Has_value", "arg1_id": "NCT03506009_exc_T16", "arg2_id": "NCT03506009_exc_T17", "normalized": [] }, { "id": "NCT03506009_exc_R7", "type": "AND", "arg1_id": "NCT03506009_exc_T19", "arg2_id": "NCT03506009_exc_T18", "normalized": [] }, { "id": "NCT03506009_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03506009_exc_T22", "arg2_id": "NCT03506009_exc_T21", "normalized": [] }, { "id": "NCT03506009_exc_R9", "type": "Has_value", "arg1_id": "NCT03506009_exc_T24", "arg2_id": "NCT03506009_exc_T23", "normalized": [] }, { "id": "NCT03506009_exc_R10", "type": "Has_value", "arg1_id": "NCT03506009_exc_T27", "arg2_id": "NCT03506009_exc_T28", "normalized": [] }, { "id": "NCT03506009_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03506009_exc_T29", "arg2_id": "NCT03506009_exc_T30", "normalized": [] }, { "id": "NCT03506009_exc_R13", "type": "Subsumes", "arg1_id": "NCT03506009_exc_T32", "arg2_id": "NCT03506009_exc_T33", "normalized": [] }, { "id": "NCT03506009_exc_R14", "type": "Has_value", "arg1_id": "NCT03506009_exc_T31", "arg2_id": "NCT03506009_exc_T32", "normalized": [] } ]

[ { "id": "NCT03506009_inc_text", "type": "inclusion", "text": [ "18-80 years old;\nDiagnosis of posterior circulation ischemic stroke;\nTime from onset to treatment =6 hours;\nNIHSS: 4-25;\nSigned informed consent by patient self or legally authorized representatives.\n" ], "offsets": [ [ 0, 200 ] ] } ]

[ { "id": "NCT03506009_inc_T1", "type": "Person", "text": [ "old" ], "offsets": [ [ 12, 15 ] ], "normalized": [] }, { "id": "NCT03506009_inc_T2", "type": "Value", "text": [ "18-80 years old" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT03506009_inc_T3", "type": "Condition", "text": [ "posterior circulation ischemic stroke" ], "offsets": [ [ 30, 67 ] ], "normalized": [] }, { "id": "NCT03506009_inc_T4", "type": "Observation", "text": [ "Time from onset to treatment" ], "offsets": [ [ 69, 97 ] ], "normalized": [] }, { "id": "NCT03506009_inc_T5", "type": "Value", "text": [ "=6 hours" ], "offsets": [ [ 98, 106 ] ], "normalized": [] }, { "id": "NCT03506009_inc_T6", "type": "Measurement", "text": [ "NIHSS" ], "offsets": [ [ 108, 113 ] ], "normalized": [] }, { "id": "NCT03506009_inc_T7", "type": "Value", "text": [ "4-25" ], "offsets": [ [ 115, 119 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03506009_inc_R1", "type": "Has_value", "arg1_id": "NCT03506009_inc_T1", "arg2_id": "NCT03506009_inc_T2", "normalized": [] }, { "id": "NCT03506009_inc_R2", "type": "Has_value", "arg1_id": "NCT03506009_inc_T4", "arg2_id": "NCT03506009_inc_T5", "normalized": [] }, { "id": "NCT03506009_inc_R3", "type": "Has_value", "arg1_id": "NCT03506009_inc_T6", "arg2_id": "NCT03506009_inc_T7", "normalized": [] } ]

[ { "id": "NCT03506477_exc_text", "type": "exclusion", "text": [ "Form of diagnosed psoriasis other than chronic plaque psoriasis (i.e. guttate, erythrodermic, pustular)\nDiagnosis of other active, ongoing skin diseases or skin infections that may interfere with examination of psoriasis lesions\nOngoing use of other psoriasis treatment including but not limited to topical or systemic corticosteroids, other topical medications (i.e. coal tar), oral or biologic medications for the treatment of psoriasis, and UV therapy. The following washout periods will be required: 2 weeks for topical therapy; 2 weeks for phototherapy; 12 weeks for biologic or targeted therapies; 4 weeks for other systemic therapies\nUse of oral estrogen therapy, excluding oral contraceptive pills\nWomen who are pregnant, nursing, or of child-bearing potential who are unwilling to use appropriate method(s) of contraception.\nPatients unwilling to limit exposure to UV light\nCurrent significant medical problems that, in the discretion of the investigator, would put the patient at significant risk\nPatients with disorders of calcium metabolism and/or hypercalcemia\nUse of any investigational drug within 4 weeks prior to randomization, or 5 pharmacokinetic/pharmacodynamics half-lives, if known (whichever is longer)\nHistory of allergy to any component of the IP\n" ], "offsets": [ [ 0, 1272 ] ] } ]

[ { "id": "NCT03506477_exc_T1", "type": "Condition", "text": [ "psoriasis" ], "offsets": [ [ 18, 27 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T2", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 28, 38 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T3", "type": "Condition", "text": [ "chronic plaque psoriasis" ], "offsets": [ [ 39, 63 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T4", "type": "Qualifier", "text": [ "guttate" ], "offsets": [ [ 70, 77 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T5", "type": "Qualifier", "text": [ "erythrodermic" ], "offsets": [ [ 79, 92 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T6", "type": "Qualifier", "text": [ "pustular" ], "offsets": [ [ 94, 102 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T7", "type": "Scope", "text": [ "other than chronic plaque psoriasis" ], "offsets": [ [ 28, 63 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T8", "type": "Scope", "text": [ "guttate, erythrodermic, pustular" ], "offsets": [ [ 70, 102 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T9", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 123, 129 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T10", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 131, 138 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T11", "type": "Condition", "text": [ "skin diseases" ], "offsets": [ [ 139, 152 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T12", "type": "Condition", "text": [ "skin infections" ], "offsets": [ [ 156, 171 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T14", "type": "Scope", "text": [ "skin diseases or skin infections" ], "offsets": [ [ 139, 171 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T15", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 260, 269 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T16", "type": "Condition", "text": [ "psoriasis" ], "offsets": [ [ 250, 259 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T17", "type": "Drug", "text": [ "pical o", "rticosteroids," ], "offsets": [ [ 301, 308 ], [ 321, 335 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T18", "type": "Drug", "text": [ "systemic corticosteroids" ], "offsets": [ [ 310, 334 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T19", "type": "Drug", "text": [ "topical medications" ], "offsets": [ [ 342, 361 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T20", "type": "Drug", "text": [ "coal tar" ], "offsets": [ [ 368, 376 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T21", "type": "Drug", "text": [ "al o", "dications f" ], "offsets": [ [ 381, 385 ], [ 398, 409 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T22", "type": "Drug", "text": [ "biologic medications" ], "offsets": [ [ 387, 407 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T24", "type": "Procedure", "text": [ "UV therapy" ], "offsets": [ [ 444, 454 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T25", "type": "Temporal", "text": [ "Ongoing" ], "offsets": [ [ 229, 236 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T26", "type": "Scope", "text": [ "topical or systemic corticosteroids, other topical medications (i.e. coal tar), oral or biologic medications for the treatment of psoriasis, and UV therapy" ], "offsets": [ [ 299, 454 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T27", "type": "Procedure", "text": [ "oral estrogen therapy" ], "offsets": [ [ 648, 669 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T28", "type": "Drug", "text": [ "oral contraceptive pills" ], "offsets": [ [ 681, 705 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T29", "type": "Negation", "text": [ "excluding" ], "offsets": [ [ 671, 680 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T31", "type": "Mood", "text": [ "unwilling" ], "offsets": [ [ 843, 852 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T32", "type": "Procedure", "text": [ "limit exposure to UV light" ], "offsets": [ [ 856, 882 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T34", "type": "Condition", "text": [ "disorders of calcium metabolism" ], "offsets": [ [ 1021, 1052 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T35", "type": "Condition", "text": [ "hypercalcemia" ], "offsets": [ [ 1060, 1073 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T37", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 1237, 1244 ] ], "normalized": [] }, { "id": "NCT03506477_exc_T38", "type": "Drug", "text": [ "any component of the IP" ], "offsets": [ [ 1248, 1271 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03506477_exc_R1", "type": "Has_negation", "arg1_id": "NCT03506477_exc_T3", "arg2_id": "NCT03506477_exc_T2", "normalized": [] }, { "id": "NCT03506477_exc_R2", "type": "Subsumes", "arg1_id": "NCT03506477_exc_T7", "arg2_id": "NCT03506477_exc_T8", "normalized": [] }, { "id": "NCT03506477_exc_R3", "type": "Has_scope", "arg1_id": "NCT03506477_exc_T1", "arg2_id": "NCT03506477_exc_T7", "normalized": [] }, { "id": "NCT03506477_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03506477_exc_T14", "arg2_id": "NCT03506477_exc_T10", "normalized": [] }, { "id": "NCT03506477_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03506477_exc_T14", "arg2_id": "NCT03506477_exc_T9", "normalized": [] }, { "id": "NCT03506477_exc_R6", "type": "AND", "arg1_id": "NCT03506477_exc_T15", "arg2_id": "NCT03506477_exc_T16", "normalized": [] }, { "id": "NCT03506477_exc_R7", "type": "Subsumes", "arg1_id": "NCT03506477_exc_T19", "arg2_id": "NCT03506477_exc_T20", "normalized": [] }, { "id": "NCT03506477_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03506477_exc_T15", "arg2_id": "NCT03506477_exc_T25", "normalized": [] }, { "id": "NCT03506477_exc_R9", "type": "Subsumes", "arg1_id": "NCT03506477_exc_T15", "arg2_id": "NCT03506477_exc_T26", "normalized": [] }, { "id": "NCT03506477_exc_R10", "type": "Has_negation", "arg1_id": "NCT03506477_exc_T28", "arg2_id": "NCT03506477_exc_T29", "normalized": [] }, { "id": "NCT03506477_exc_R11", "type": "AND", "arg1_id": "NCT03506477_exc_T27", "arg2_id": "NCT03506477_exc_T28", "normalized": [] }, { "id": "NCT03506477_exc_R12", "type": "Has_mood", "arg1_id": "NCT03506477_exc_T32", "arg2_id": "NCT03506477_exc_T31", "normalized": [] }, { "id": "NCT03506477_exc_R13", "type": "AND", "arg1_id": "NCT03506477_exc_T37", "arg2_id": "NCT03506477_exc_T38", "normalized": [] } ]

[ { "id": "NCT03506477_inc_text", "type": "inclusion", "text": [ "Provide written, signed and dated informed consent prior to initiating any study-related activities.\nMale or female >18 years of age at the time of screening\nFitzpatrick Skin phototype IV-VI, non-white race/ethnicity, including but not limited to - --African Americans, Asians, Pacific Islanders and Hispanics.\nClinical diagnosis of chronic plaque-type psoriasis of the body\nPlaque psoriasis with =2% Body Surface Area (BSA) involvement (may include scalp involvement), PASI Score = 2, IGA mod 2011 score of 2 or greater (based on scale of 0-4)\nFemales of childbearing potential (FCBP) must have a negative pregnancy test at Screening and Baseline. While using investigational product and for at least 28 days after last application of investigational product, FCBP who engage in activity in which conception is possible must use one of the approved contraceptive options d\nMust be in general good health as judged by the Investigator, based on medical history and physical examination.\n" ], "offsets": [ [ 0, 987 ] ] } ]

[ { "id": "NCT03506477_inc_T2", "type": "Person", "text": [ "Male" ], "offsets": [ [ 101, 105 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T3", "type": "Person", "text": [ "female" ], "offsets": [ [ 109, 115 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T4", "type": "Value", "text": [ ">18 years of age" ], "offsets": [ [ 116, 132 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T5", "type": "Person", "text": [ "age" ], "offsets": [ [ 129, 132 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T6", "type": "Temporal", "text": [ "at the time of screening" ], "offsets": [ [ 133, 157 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T7", "type": "Reference_point", "text": [ "the time of screening" ], "offsets": [ [ 136, 157 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T8", "type": "Measurement", "text": [ "Fitzpatrick Skin phototype" ], "offsets": [ [ 158, 184 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T9", "type": "Value", "text": [ "IV-VI" ], "offsets": [ [ 185, 190 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T10", "type": "Person", "text": [ "non-white race/ethnicity" ], "offsets": [ [ 192, 216 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T11", "type": "Person", "text": [ "African Americans" ], "offsets": [ [ 251, 268 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T12", "type": "Person", "text": [ "Asians" ], "offsets": [ [ 270, 276 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T13", "type": "Person", "text": [ "Pacific Islanders" ], "offsets": [ [ 278, 295 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T14", "type": "Person", "text": [ "Hispanics" ], "offsets": [ [ 300, 309 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T15", "type": "Scope", "text": [ "African Americans, Asians, Pacific Islanders and Hispanics" ], "offsets": [ [ 251, 309 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T16", "type": "Qualifier", "text": [ "plaque-type" ], "offsets": [ [ 341, 352 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T17", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 333, 340 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T18", "type": "Condition", "text": [ "psoriasis of the body" ], "offsets": [ [ 353, 374 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T19", "type": "Condition", "text": [ "Plaque psoriasis" ], "offsets": [ [ 375, 391 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T20", "type": "Value", "text": [ "=2% Body Surface Area (BSA)" ], "offsets": [ [ 397, 424 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T21", "type": "Measurement", "text": [ "involvement" ], "offsets": [ [ 425, 436 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T22", "type": "Measurement", "text": [ "PASI Score" ], "offsets": [ [ 470, 480 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T23", "type": "Value", "text": [ "= 2" ], "offsets": [ [ 481, 484 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T24", "type": "Measurement", "text": [ "IGA mod 2011 score" ], "offsets": [ [ 486, 504 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T25", "type": "Value", "text": [ "2 or greater" ], "offsets": [ [ 508, 520 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T26", "type": "Qualifier", "text": [ "scale of 0-4" ], "offsets": [ [ 531, 543 ] ], "normalized": [] }, { "id": "NCT03506477_inc_T27", "type": "Scope", "text": [ "=2% Body Surface Area (BSA) involvement (may include scalp involvement), PASI Score = 2, IGA mod 2011 score of 2 or greater (based on scale of 0-4)" ], "offsets": [ [ 397, 544 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03506477_inc_R1", "type": "Has_value", "arg1_id": "NCT03506477_inc_T5", "arg2_id": "NCT03506477_inc_T4", "normalized": [] }, { "id": "NCT03506477_inc_R2", "type": "Has_index", "arg1_id": "NCT03506477_inc_T6", "arg2_id": "NCT03506477_inc_T7", "normalized": [] }, { "id": "NCT03506477_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03506477_inc_T4", "arg2_id": "NCT03506477_inc_T6", "normalized": [] }, { "id": "NCT03506477_inc_R4", "type": "Has_value", "arg1_id": "NCT03506477_inc_T8", "arg2_id": "NCT03506477_inc_T9", "normalized": [] }, { "id": "NCT03506477_inc_R5", "type": "Subsumes", "arg1_id": "NCT03506477_inc_T10", "arg2_id": "NCT03506477_inc_T15", "normalized": [] }, { "id": "NCT03506477_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03506477_inc_T18", "arg2_id": "NCT03506477_inc_T16", "normalized": [] }, { "id": "NCT03506477_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT03506477_inc_T18", "arg2_id": "NCT03506477_inc_T17", "normalized": [] }, { "id": "NCT03506477_inc_R8", "type": "Has_value", "arg1_id": "NCT03506477_inc_T21", "arg2_id": "NCT03506477_inc_T20", "normalized": [] }, { "id": "NCT03506477_inc_R9", "type": "Has_value", "arg1_id": "NCT03506477_inc_T24", "arg2_id": "NCT03506477_inc_T25", "normalized": [] }, { "id": "NCT03506477_inc_R10", "type": "Has_value", "arg1_id": "NCT03506477_inc_T22", "arg2_id": "NCT03506477_inc_T23", "normalized": [] }, { "id": "NCT03506477_inc_R11", "type": "Has_scope", "arg1_id": "NCT03506477_inc_T19", "arg2_id": "NCT03506477_inc_T27", "normalized": [] } ]

[ { "id": "NCT03506750_exc_text", "type": "exclusion", "text": [ "previous retinal vein occlusion.\nany intraocular surgery within the previous 12 months.\nmyopia of > or = to 8 diopters.\nactive ocular or periocular infection\ntreatment with an investigational agent for any condition 60 days prior to enrollment.\nevidence of severe cardiac disease.\nclinically significant peripheral vascular disease (previous surgery, amputation, or symptoms of claudication)\nuncontrolled hypertension (treated systolic blood pressure > 155 mmHg or diastolic blood pressure > 95 mmHg)\nstroke within the preceding 12 months.\n" ], "offsets": [ [ 0, 540 ] ] } ]

[ { "id": "NCT03506750_exc_T1", "type": "Condition", "text": [ "retinal vein occlusion" ], "offsets": [ [ 9, 31 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T2", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T3", "type": "Procedure", "text": [ "intraocular surgery" ], "offsets": [ [ 37, 56 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T4", "type": "Temporal", "text": [ "within the previous 12 months" ], "offsets": [ [ 57, 86 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T5", "type": "Condition", "text": [ "myopia" ], "offsets": [ [ 88, 94 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T6", "type": "Value", "text": [ "> or = to 8 diopters" ], "offsets": [ [ 98, 118 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T7", "type": "Condition", "text": [ "periocular infection" ], "offsets": [ [ 137, 157 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T8", "type": "Condition", "text": [ "lar or", "ection\ntr" ], "offsets": [ [ 130, 136 ], [ 151, 160 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T9", "type": "Scope", "text": [ "ocular or periocular infection" ], "offsets": [ [ 127, 157 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T10", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 120, 126 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T12", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 257, 263 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T13", "type": "Condition", "text": [ "cardiac disease" ], "offsets": [ [ 264, 279 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T14", "type": "Mood", "text": [ "evidence of" ], "offsets": [ [ 245, 256 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T15", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 281, 303 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T16", "type": "Condition", "text": [ "peripheral vascular disease" ], "offsets": [ [ 304, 331 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T17", "type": "Procedure", "text": [ "previous surgery" ], "offsets": [ [ 333, 349 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T18", "type": "Procedure", "text": [ "amputation" ], "offsets": [ [ 351, 361 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T19", "type": "Condition", "text": [ "symptoms of claudication" ], "offsets": [ [ 366, 390 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T20", "type": "Scope", "text": [ "previous surgery, amputation, or symptoms of claudication" ], "offsets": [ [ 333, 390 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T21", "type": "Scope", "text": [ "clinically significant peripheral vascular disease" ], "offsets": [ [ 281, 331 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T22", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 405, 417 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T23", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 392, 404 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T24", "type": "Measurement", "text": [ "systolic blood pressure" ], "offsets": [ [ 427, 450 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T25", "type": "Qualifier", "text": [ "treated" ], "offsets": [ [ 419, 426 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T26", "type": "Value", "text": [ "> 155 mmHg" ], "offsets": [ [ 451, 461 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T27", "type": "Measurement", "text": [ "diastolic blood pressure" ], "offsets": [ [ 465, 489 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T28", "type": "Value", "text": [ "> 95 mmHg" ], "offsets": [ [ 490, 499 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T29", "type": "Scope", "text": [ "systolic blood pressure > 155 mmHg or diastolic blood pressure > 95 mmHg" ], "offsets": [ [ 427, 499 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T30", "type": "Scope", "text": [ "uncontrolled hypertension" ], "offsets": [ [ 392, 417 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T31", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 501, 507 ] ], "normalized": [] }, { "id": "NCT03506750_exc_T32", "type": "Temporal", "text": [ "within the preceding 12 months" ], "offsets": [ [ 508, 538 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03506750_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03506750_exc_T1", "arg2_id": "NCT03506750_exc_T2", "normalized": [] }, { "id": "NCT03506750_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03506750_exc_T3", "arg2_id": "NCT03506750_exc_T4", "normalized": [] }, { "id": "NCT03506750_exc_R3", "type": "Has_value", "arg1_id": "NCT03506750_exc_T5", "arg2_id": "NCT03506750_exc_T6", "normalized": [] }, { "id": "NCT03506750_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03506750_exc_T9", "arg2_id": "NCT03506750_exc_T10", "normalized": [] }, { "id": "NCT03506750_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03506750_exc_T13", "arg2_id": "NCT03506750_exc_T12", "normalized": [] }, { "id": "NCT03506750_exc_R6", "type": "Has_mood", "arg1_id": "NCT03506750_exc_T13", "arg2_id": "NCT03506750_exc_T14", "normalized": [] }, { "id": "NCT03506750_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03506750_exc_T16", "arg2_id": "NCT03506750_exc_T15", "normalized": [] }, { "id": "NCT03506750_exc_R8", "type": "Subsumes", "arg1_id": "NCT03506750_exc_T21", "arg2_id": "NCT03506750_exc_T20", "normalized": [] }, { "id": "NCT03506750_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03506750_exc_T22", "arg2_id": "NCT03506750_exc_T23", "normalized": [] }, { "id": "NCT03506750_exc_R10", "type": "Has_value", "arg1_id": "NCT03506750_exc_T24", "arg2_id": "NCT03506750_exc_T26", "normalized": [] }, { "id": "NCT03506750_exc_R11", "type": "Has_value", "arg1_id": "NCT03506750_exc_T27", "arg2_id": "NCT03506750_exc_T28", "normalized": [] }, { "id": "NCT03506750_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03506750_exc_T29", "arg2_id": "NCT03506750_exc_T25", "normalized": [] }, { "id": "NCT03506750_exc_R13", "type": "Subsumes", "arg1_id": "NCT03506750_exc_T30", "arg2_id": "NCT03506750_exc_T29", "normalized": [] }, { "id": "NCT03506750_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03506750_exc_T31", "arg2_id": "NCT03506750_exc_T32", "normalized": [] } ]

[ { "id": "NCT03506750_inc_text", "type": "inclusion", "text": [ "18 years or older\nType 1 or 2 diabetes\nPDR patients requiring surgical intervention for complications of vitreous hemorrhage or traction retinal detachment and pre-operative IVC treatment.\nwomen postmenopausal for 12 months before the study, surgically sterile, or not pregnant and on effective contraception.\n" ], "offsets": [ [ 0, 310 ] ] } ]

[ { "id": "NCT03506750_inc_T1", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T2", "type": "Person", "text": [ "older" ], "offsets": [ [ 12, 17 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T3", "type": "Condition", "text": [ "ype 1", "iabetes" ], "offsets": [ [ 19, 24 ], [ 31, 38 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T4", "type": "Condition", "text": [ "ype", " diabete" ], "offsets": [ [ 19, 22 ], [ 29, 37 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T5", "type": "Condition", "text": [ "PDR" ], "offsets": [ [ 39, 42 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T6", "type": "Procedure", "text": [ "surgical intervention" ], "offsets": [ [ 62, 83 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T7", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 52, 61 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T8", "type": "Condition", "text": [ "vitreous hemorrhage" ], "offsets": [ [ 105, 124 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T9", "type": "Condition", "text": [ "traction retinal detachment" ], "offsets": [ [ 128, 155 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T10", "type": "Qualifier", "text": [ "pre-operative" ], "offsets": [ [ 160, 173 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T11", "type": "Procedure", "text": [ "IVC treatment" ], "offsets": [ [ 174, 187 ] ], "normalized": [] }, { "id": "NCT03506750_inc_T12", "type": "Scope", "text": [ "vitreous hemorrhage or traction retinal detachment and pre-operative IVC treatment" ], "offsets": [ [ 105, 187 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03506750_inc_R1", "type": "Has_value", "arg1_id": "NCT03506750_inc_T2", "arg2_id": "NCT03506750_inc_T1", "normalized": [] }, { "id": "NCT03506750_inc_R2", "type": "Has_mood", "arg1_id": "NCT03506750_inc_T6", "arg2_id": "NCT03506750_inc_T7", "normalized": [] }, { "id": "NCT03506750_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03506750_inc_T11", "arg2_id": "NCT03506750_inc_T10", "normalized": [] }, { "id": "NCT03506750_inc_R4", "type": "Has_scope", "arg1_id": "NCT03506750_inc_T6", "arg2_id": "NCT03506750_inc_T12", "normalized": [] } ]

[ { "id": "NCT03511521_exc_text", "type": "exclusion", "text": [ "Patients with 2 or more doses of methylprednisolone/prednisone per day\nSteroids other than methylprednisolone or prednisone\nPregnancy\nestimated glomerular filtration rate (eGFR) < 45 ml/min/1.73m2\n" ], "offsets": [ [ 0, 197 ] ] } ]

[ { "id": "NCT03511521_exc_T1", "type": "Multiplier", "text": [ "2 or more doses", "per day" ], "offsets": [ [ 14, 29 ], [ 63, 70 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T2", "type": "Drug", "text": [ "methylprednisolone" ], "offsets": [ [ 33, 51 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T3", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 52, 62 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T4", "type": "Scope", "text": [ "methylprednisolone/prednisone" ], "offsets": [ [ 33, 62 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T5", "type": "Drug", "text": [ "methylprednisolone" ], "offsets": [ [ 91, 109 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T6", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 113, 123 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T7", "type": "Drug", "text": [ "Steroids" ], "offsets": [ [ 71, 79 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T8", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 80, 90 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T9", "type": "Scope", "text": [ "methylprednisolone or prednisone" ], "offsets": [ [ 91, 123 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T10", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 124, 133 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T11", "type": "Measurement", "text": [ "estimated glomerular filtration rate (eGFR)" ], "offsets": [ [ 134, 177 ] ], "normalized": [] }, { "id": "NCT03511521_exc_T12", "type": "Value", "text": [ "< 45 ml/min/1.73m2" ], "offsets": [ [ 178, 196 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03511521_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT03511521_exc_T4", "arg2_id": "NCT03511521_exc_T1", "normalized": [] }, { "id": "NCT03511521_exc_R2", "type": "Has_negation", "arg1_id": "NCT03511521_exc_T9", "arg2_id": "NCT03511521_exc_T8", "normalized": [] }, { "id": "NCT03511521_exc_R3", "type": "Has_scope", "arg1_id": "NCT03511521_exc_T7", "arg2_id": "NCT03511521_exc_T9", "normalized": [] }, { "id": "NCT03511521_exc_R4", "type": "Has_value", "arg1_id": "NCT03511521_exc_T11", "arg2_id": "NCT03511521_exc_T12", "normalized": [] } ]

[ { "id": "NCT03511521_inc_text", "type": "inclusion", "text": [ "Patients receiving once daily dosing of methylprednisolone or prednisone in a dose of 10 mg/day or greater\nHyperglycemic (Glucose level > 126 mg/dL)\nDiabetic and nondiabetic patients\nExpected duration of hospital stay and time on steroids >= 3 days\nPatient of appropriate caregiver able to give Informed Consent\n" ], "offsets": [ [ 0, 312 ] ] } ]

[ { "id": "NCT03511521_inc_T1", "type": "Multiplier", "text": [ "once daily" ], "offsets": [ [ 19, 29 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T2", "type": "Drug", "text": [ "methylprednisolone" ], "offsets": [ [ 40, 58 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T3", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 62, 72 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T4", "type": "Multiplier", "text": [ "10 mg/day or greater" ], "offsets": [ [ 86, 106 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T5", "type": "Scope", "text": [ "methylprednisolone or prednisone" ], "offsets": [ [ 40, 72 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T6", "type": "Condition", "text": [ "Hyperglycemic" ], "offsets": [ [ 107, 120 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T7", "type": "Measurement", "text": [ "Glucose level" ], "offsets": [ [ 122, 135 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T8", "type": "Value", "text": [ "> 126 mg/dL" ], "offsets": [ [ 136, 147 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T9", "type": "Scope", "text": [ "Glucose level > 126 mg/dL" ], "offsets": [ [ 122, 147 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T10", "type": "Condition", "text": [ "nondiabetic" ], "offsets": [ [ 162, 173 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T11", "type": "Condition", "text": [ "Diabetic" ], "offsets": [ [ 149, 157 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T12", "type": "Measurement", "text": [ "Expected duration of hospital stay" ], "offsets": [ [ 183, 217 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T13", "type": "Measurement", "text": [ "time on steroids" ], "offsets": [ [ 222, 238 ] ], "normalized": [] }, { "id": "NCT03511521_inc_T14", "type": "Value", "text": [ ">= 3 days" ], "offsets": [ [ 239, 248 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03511521_inc_R1", "type": "Has_multiplier", "arg1_id": "NCT03511521_inc_T5", "arg2_id": "NCT03511521_inc_T1", "normalized": [] }, { "id": "NCT03511521_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT03511521_inc_T5", "arg2_id": "NCT03511521_inc_T4", "normalized": [] }, { "id": "NCT03511521_inc_R3", "type": "Has_value", "arg1_id": "NCT03511521_inc_T7", "arg2_id": "NCT03511521_inc_T8", "normalized": [] }, { "id": "NCT03511521_inc_R4", "type": "Has_scope", "arg1_id": "NCT03511521_inc_T6", "arg2_id": "NCT03511521_inc_T9", "normalized": [] }, { "id": "NCT03511521_inc_R5", "type": "Has_value", "arg1_id": "NCT03511521_inc_T13", "arg2_id": "NCT03511521_inc_T14", "normalized": [] }, { "id": "NCT03511521_inc_R6", "type": "Has_value", "arg1_id": "NCT03511521_inc_T12", "arg2_id": "NCT03511521_inc_T14", "normalized": [] } ]

[ { "id": "NCT03513757_exc_text", "type": "exclusion", "text": [ "Inpatient status, airway abnormalities, allergy to any study medications, eggs and soy, and mitochondrial disorders.\nAll subjects with any cardiac disease or history of cardiac arrhythmias will be excluded.\n" ], "offsets": [ [ 0, 207 ] ] } ]

[ { "id": "NCT03513757_exc_T1", "type": "Observation", "text": [ "Inpatient status" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T2", "type": "Condition", "text": [ "airway abnormalities" ], "offsets": [ [ 18, 38 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T3", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 40, 47 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T4", "type": "Drug", "text": [ "study medications" ], "offsets": [ [ 55, 72 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T5", "type": "Drug", "text": [ "eggs" ], "offsets": [ [ 74, 78 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T6", "type": "Drug", "text": [ "soy" ], "offsets": [ [ 83, 86 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T7", "type": "Condition", "text": [ "mitochondrial disorders" ], "offsets": [ [ 92, 115 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T8", "type": "Scope", "text": [ "study medications, eggs and soy" ], "offsets": [ [ 55, 86 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T9", "type": "Condition", "text": [ "cardiac disease" ], "offsets": [ [ 139, 154 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T10", "type": "Condition", "text": [ "cardiac arrhythmias" ], "offsets": [ [ 169, 188 ] ], "normalized": [] }, { "id": "NCT03513757_exc_T11", "type": "Observation", "text": [ "history" ], "offsets": [ [ 158, 165 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03513757_exc_R1", "type": "Has_scope", "arg1_id": "NCT03513757_exc_T3", "arg2_id": "NCT03513757_exc_T8", "normalized": [] }, { "id": "NCT03513757_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03513757_exc_T10", "arg2_id": "NCT03513757_exc_T11", "normalized": [] } ]

[ { "id": "NCT03513757_inc_text", "type": "inclusion", "text": [ "All children scheduled for outpatient MRI scans with expected duration of scan between 30 minutes and 75 minutes.\n" ], "offsets": [ [ 0, 114 ] ] } ]

[ { "id": "NCT03513757_inc_T1", "type": "Qualifier", "text": [ "outpatient" ], "offsets": [ [ 27, 37 ] ], "normalized": [] }, { "id": "NCT03513757_inc_T2", "type": "Procedure", "text": [ "MRI scans" ], "offsets": [ [ 38, 47 ] ], "normalized": [] }, { "id": "NCT03513757_inc_T3", "type": "Measurement", "text": [ "expected duration of scan" ], "offsets": [ [ 53, 78 ] ], "normalized": [] }, { "id": "NCT03513757_inc_T4", "type": "Value", "text": [ "between 30 minutes and 75 minutes" ], "offsets": [ [ 79, 112 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03513757_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03513757_inc_T2", "arg2_id": "NCT03513757_inc_T1", "normalized": [] }, { "id": "NCT03513757_inc_R2", "type": "Has_value", "arg1_id": "NCT03513757_inc_T3", "arg2_id": "NCT03513757_inc_T4", "normalized": [] } ]

[ { "id": "NCT03513874_exc_text", "type": "exclusion", "text": [ "History of any malignancy or other severe diseases\nFemale patients who are pregnant or breastfeeding before or during the three-year follow-up\nPoor compliance or refusal to participate.\n" ], "offsets": [ [ 0, 186 ] ] } ]

[ { "id": "NCT03513874_exc_T1", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 15, 25 ] ], "normalized": [] }, { "id": "NCT03513874_exc_T2", "type": "Condition", "text": [ "severe diseases" ], "offsets": [ [ 35, 50 ] ], "normalized": [] }, { "id": "NCT03513874_exc_T4", "type": "Observation", "text": [ "Poor compliance" ], "offsets": [ [ 143, 158 ] ], "normalized": [] }, { "id": "NCT03513874_exc_T5", "type": "Observation", "text": [ "refusal to participate" ], "offsets": [ [ 162, 184 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT03513874_inc_text", "type": "inclusion", "text": [ "Type 1 diabetes according to ADA criterias <5 years.\nAge= 18 years and less than 70 years.\nNon-obese: defined as BMI less than 28 kg/m2\nPositive for at least one of the anti-islet autoantibodies: GADA, IA2A, ZnT8A\nFasting or postprandial plasma C-peptide more than 100 pmol/L\nWritten informed consent from the patient or family representative.\n" ], "offsets": [ [ 0, 344 ] ] } ]

[ { "id": "NCT03513874_inc_T1", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T2", "type": "Qualifier", "text": [ "ADA criterias" ], "offsets": [ [ 29, 42 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T3", "type": "Temporal", "text": [ "<5 years" ], "offsets": [ [ 43, 51 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T4", "type": "Person", "text": [ "Age" ], "offsets": [ [ 53, 56 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T5", "type": "Value", "text": [ "= 18 years and less than 70 years" ], "offsets": [ [ 56, 89 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T6", "type": "Negation", "text": [ "Non" ], "offsets": [ [ 91, 94 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T7", "type": "Condition", "text": [ "obese" ], "offsets": [ [ 95, 100 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T8", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 113, 116 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T9", "type": "Value", "text": [ "less than 28 kg/m2" ], "offsets": [ [ 117, 135 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T10", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 149, 161 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T11", "type": "Condition", "text": [ "anti-islet autoantibodies" ], "offsets": [ [ 169, 194 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T12", "type": "Condition", "text": [ "GADA" ], "offsets": [ [ 196, 200 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T13", "type": "Condition", "text": [ "IA2A" ], "offsets": [ [ 202, 206 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T14", "type": "Condition", "text": [ "ZnT8A" ], "offsets": [ [ 208, 213 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T15", "type": "Scope", "text": [ "GADA, IA2A, ZnT8A" ], "offsets": [ [ 196, 213 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T16", "type": "Measurement", "text": [ "postprandial plasma C-peptide" ], "offsets": [ [ 225, 254 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T17", "type": "Measurement", "text": [ "ing or", "ma C-peptide mor" ], "offsets": [ [ 218, 224 ], [ 242, 258 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T18", "type": "Scope", "text": [ "Fasting or postprandial plasma C-peptide" ], "offsets": [ [ 214, 254 ] ], "normalized": [] }, { "id": "NCT03513874_inc_T19", "type": "Value", "text": [ "more than 100 pmol/L" ], "offsets": [ [ 255, 275 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03513874_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03513874_inc_T1", "arg2_id": "NCT03513874_inc_T2", "normalized": [] }, { "id": "NCT03513874_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03513874_inc_T1", "arg2_id": "NCT03513874_inc_T3", "normalized": [] }, { "id": "NCT03513874_inc_R3", "type": "Has_value", "arg1_id": "NCT03513874_inc_T4", "arg2_id": "NCT03513874_inc_T5", "normalized": [] }, { "id": "NCT03513874_inc_R4", "type": "Has_negation", "arg1_id": "NCT03513874_inc_T7", "arg2_id": "NCT03513874_inc_T6", "normalized": [] }, { "id": "NCT03513874_inc_R5", "type": "Has_value", "arg1_id": "NCT03513874_inc_T8", "arg2_id": "NCT03513874_inc_T9", "normalized": [] }, { "id": "NCT03513874_inc_R6", "type": "Subsumes", "arg1_id": "NCT03513874_inc_T11", "arg2_id": "NCT03513874_inc_T15", "normalized": [] }, { "id": "NCT03513874_inc_R7", "type": "Has_multiplier", "arg1_id": "NCT03513874_inc_T11", "arg2_id": "NCT03513874_inc_T10", "normalized": [] }, { "id": "NCT03513874_inc_R8", "type": "Has_value", "arg1_id": "NCT03513874_inc_T18", "arg2_id": "NCT03513874_inc_T19", "normalized": [] } ]

[ { "id": "NCT03518034_exc_text", "type": "exclusion", "text": [ "Participants with congenital or acquired hypogonadism for whom long-term therapy with placebo would not be medically appropriate\nParticipants with prostate specific antigen (PSA) > 3.0 ng/mL (or 1.5 if on 5-alpha reductase inhibitors)\nParticipants who have been treated with testosterone in the past 6 months and for whom testosterone therapy is contraindicated\nConfirmed testosterone < 100 ng/dL\nBody Mass Index (BMI) > 50\nHemoglobin A1c (HbA1C) > 11%\nHematocrit (Hct) > 50%\nEstimated Glomerular Filtration Rate (eGFR) < 30 ml/min\nHistory of deep vein thrombosis or pulmonary embolism or prostate cancer or heart failure (Class III and IV).\n" ], "offsets": [ [ 0, 642 ] ] } ]

[ { "id": "NCT03518034_exc_T1", "type": "Condition", "text": [ "acquired hypogonadism" ], "offsets": [ [ 32, 53 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T2", "type": "Condition", "text": [ "congenital", "hypogonadism" ], "offsets": [ [ 18, 28 ], [ 41, 53 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T4", "type": "Measurement", "text": [ "prostate specific antigen (PSA)" ], "offsets": [ [ 147, 178 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T5", "type": "Value", "text": [ "> 3.0 ng/mL" ], "offsets": [ [ 179, 190 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T6", "type": "Drug", "text": [ "5-alpha reductase inhibitors" ], "offsets": [ [ 205, 233 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T7", "type": "Value", "text": [ "1.5" ], "offsets": [ [ 195, 198 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T8", "type": "Scope", "text": [ "> 3.0 ng/mL (or 1.5 if on 5-alpha reductase inhibitors)" ], "offsets": [ [ 179, 234 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T9", "type": "Drug", "text": [ "testosterone" ], "offsets": [ [ 275, 287 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T10", "type": "Temporal", "text": [ "in the past 6 months" ], "offsets": [ [ 288, 308 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T11", "type": "Condition", "text": [ "contraindicated" ], "offsets": [ [ 346, 361 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T12", "type": "Procedure", "text": [ "testosterone therapy" ], "offsets": [ [ 322, 342 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T13", "type": "Drug", "text": [ "testosterone" ], "offsets": [ [ 322, 334 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T14", "type": "Measurement", "text": [ "Confirmed testosterone" ], "offsets": [ [ 362, 384 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T15", "type": "Value", "text": [ "< 100 ng/dL" ], "offsets": [ [ 385, 396 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T16", "type": "Measurement", "text": [ "Body Mass Index (BMI)" ], "offsets": [ [ 397, 418 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T17", "type": "Value", "text": [ "> 50" ], "offsets": [ [ 419, 423 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T18", "type": "Measurement", "text": [ "Hemoglobin A1c (HbA1C)" ], "offsets": [ [ 424, 446 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T19", "type": "Value", "text": [ "> 11%" ], "offsets": [ [ 447, 452 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T20", "type": "Measurement", "text": [ "Hematocrit (Hct)" ], "offsets": [ [ 453, 469 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T21", "type": "Value", "text": [ "> 50%" ], "offsets": [ [ 470, 475 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T22", "type": "Measurement", "text": [ "Estimated Glomerular Filtration Rate (eGFR)" ], "offsets": [ [ 476, 519 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T23", "type": "Value", "text": [ "< 30 ml/min" ], "offsets": [ [ 520, 531 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T24", "type": "Condition", "text": [ "deep vein thrombosis" ], "offsets": [ [ 543, 563 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T25", "type": "Condition", "text": [ "pulmonary embolism" ], "offsets": [ [ 567, 585 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T26", "type": "Condition", "text": [ "prostate cancer" ], "offsets": [ [ 589, 604 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T27", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 608, 621 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T28", "type": "Qualifier", "text": [ "Class III" ], "offsets": [ [ 623, 632 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T29", "type": "Qualifier", "text": [ "I and", "" ], "offsets": [ [ 631, 636 ], [ 645, 645 ] ], "normalized": [] }, { "id": "NCT03518034_exc_T30", "type": "Scope", "text": [ "Class III and IV" ], "offsets": [ [ 623, 639 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03518034_exc_R1", "type": "Has_value", "arg1_id": "NCT03518034_exc_T6", "arg2_id": "NCT03518034_exc_T7", "normalized": [] }, { "id": "NCT03518034_exc_R2", "type": "Has_scope", "arg1_id": "NCT03518034_exc_T4", "arg2_id": "NCT03518034_exc_T8", "normalized": [] }, { "id": "NCT03518034_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03518034_exc_T9", "arg2_id": "NCT03518034_exc_T10", "normalized": [] }, { "id": "NCT03518034_exc_R4", "type": "AND", "arg1_id": "NCT03518034_exc_T11", "arg2_id": "NCT03518034_exc_T12", "normalized": [] }, { "id": "NCT03518034_exc_R6", "type": "Has_value", "arg1_id": "NCT03518034_exc_T14", "arg2_id": "NCT03518034_exc_T15", "normalized": [] }, { "id": "NCT03518034_exc_R7", "type": "Has_value", "arg1_id": "NCT03518034_exc_T16", "arg2_id": "NCT03518034_exc_T17", "normalized": [] }, { "id": "NCT03518034_exc_R8", "type": "Has_value", "arg1_id": "NCT03518034_exc_T18", "arg2_id": "NCT03518034_exc_T19", "normalized": [] }, { "id": "NCT03518034_exc_R9", "type": "Has_value", "arg1_id": "NCT03518034_exc_T20", "arg2_id": "NCT03518034_exc_T21", "normalized": [] }, { "id": "NCT03518034_exc_R10", "type": "Has_value", "arg1_id": "NCT03518034_exc_T22", "arg2_id": "NCT03518034_exc_T23", "normalized": [] }, { "id": "NCT03518034_exc_R11", "type": "Has_scope", "arg1_id": "NCT03518034_exc_T27", "arg2_id": "NCT03518034_exc_T30", "normalized": [] } ]

[ { "id": "NCT03518034_inc_text", "type": "inclusion", "text": [ "Men between 45 and 80 years age\nParticipants with low serum testosterone concentrations (< 300 ng/dL) who exhibit at least one sign or symptom of hypogonadism and have evidence of cardiovascular (CV) disease or are at an increased risk for CV disease.\n" ], "offsets": [ [ 0, 252 ] ] } ]

[ { "id": "NCT03518034_inc_T1", "type": "Person", "text": [ "Men" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T2", "type": "Value", "text": [ "between 45 and 80 years" ], "offsets": [ [ 4, 27 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 28, 31 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T4", "type": "Measurement", "text": [ "serum testosterone concentrations" ], "offsets": [ [ 54, 87 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T5", "type": "Value", "text": [ "low" ], "offsets": [ [ 50, 53 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T6", "type": "Value", "text": [ "< 300 ng/dL" ], "offsets": [ [ 89, 100 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T7", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 114, 126 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T8", "type": "Condition", "text": [ "sign" ], "offsets": [ [ 127, 131 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T9", "type": "Condition", "text": [ "symptom" ], "offsets": [ [ 135, 142 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T10", "type": "Condition", "text": [ "hypogonadism" ], "offsets": [ [ 146, 158 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T11", "type": "Scope", "text": [ "sign or symptom" ], "offsets": [ [ 127, 142 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T12", "type": "Mood", "text": [ "evidence of" ], "offsets": [ [ 168, 179 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T13", "type": "Condition", "text": [ "cardiovascular (CV) disease" ], "offsets": [ [ 180, 207 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T14", "type": "Mood", "text": [ "increased risk" ], "offsets": [ [ 221, 235 ] ], "normalized": [] }, { "id": "NCT03518034_inc_T15", "type": "Condition", "text": [ "CV disease" ], "offsets": [ [ 240, 250 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03518034_inc_R1", "type": "Has_value", "arg1_id": "NCT03518034_inc_T3", "arg2_id": "NCT03518034_inc_T2", "normalized": [] }, { "id": "NCT03518034_inc_R2", "type": "Subsumes", "arg1_id": "NCT03518034_inc_T5", "arg2_id": "NCT03518034_inc_T6", "normalized": [] }, { "id": "NCT03518034_inc_R3", "type": "Has_value", "arg1_id": "NCT03518034_inc_T4", "arg2_id": "NCT03518034_inc_T5", "normalized": [] }, { "id": "NCT03518034_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT03518034_inc_T11", "arg2_id": "NCT03518034_inc_T7", "normalized": [] }, { "id": "NCT03518034_inc_R5", "type": "AND", "arg1_id": "NCT03518034_inc_T11", "arg2_id": "NCT03518034_inc_T10", "normalized": [] }, { "id": "NCT03518034_inc_R6", "type": "Has_mood", "arg1_id": "NCT03518034_inc_T13", "arg2_id": "NCT03518034_inc_T12", "normalized": [] }, { "id": "NCT03518034_inc_R7", "type": "Has_mood", "arg1_id": "NCT03518034_inc_T15", "arg2_id": "NCT03518034_inc_T14", "normalized": [] } ]

[ { "id": "NCT03519568_exc_text", "type": "exclusion", "text": [ "the history or family history of anaphylaxis, convulsion, epilepsy, encephalopathy and psychosis\nthe history of severe inoculation allergies\npatients with immunodeficiency and malignant tumors during the treatment period, receiving immunosuppressive therapy (oral steroid) or HIV due to low immunity, or family members have congenital immune disease\nNonspecific immunoglobulin was injected within one month\ntemperature=37.1<U+2103> and infectious diseases\nthe history of thrombocytopenia or other thrombocytopenia with a definite diagnosis\nrespiratory disease, acute infection or chronic disease activity period\nsevere cardiovascular disease, liver and kidney disease, and complications of diabetes\ninfectious, suppurative and allergic dermatosis\nother conditions that may affect the evaluation of the trail\nany serious adverse events that have a causal relationship with the inoculation of the upper dose of the vaccine\nthe abnormality of 4 levels (local, systemic adverse reactions and vital signs) was judged to be related to vaccination\nother new standards of exclusion criteria for first needle\nother conditions that may affect the evaluation of the trail\n" ], "offsets": [ [ 0, 1161 ] ] } ]

[ { "id": "NCT03519568_exc_T1", "type": "Observation", "text": [ "history" ], "offsets": [ [ 4, 11 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T2", "type": "Observation", "text": [ "family history" ], "offsets": [ [ 15, 29 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T3", "type": "Condition", "text": [ "anaphylaxis" ], "offsets": [ [ 33, 44 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T4", "type": "Condition", "text": [ "convulsion" ], "offsets": [ [ 46, 56 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T5", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 58, 66 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T6", "type": "Condition", "text": [ "encephalopathy" ], "offsets": [ [ 68, 82 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T7", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 87, 96 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T8", "type": "Scope", "text": [ "anaphylaxis, convulsion, epilepsy, encephalopathy and psychosis" ], "offsets": [ [ 33, 96 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T9", "type": "Scope", "text": [ "history or family history" ], "offsets": [ [ 4, 29 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T10", "type": "Condition", "text": [ "inoculation allergies" ], "offsets": [ [ 119, 140 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T11", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 112, 118 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T12", "type": "Observation", "text": [ "history" ], "offsets": [ [ 101, 108 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T13", "type": "Condition", "text": [ "malignant tumors" ], "offsets": [ [ 176, 192 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T14", "type": "Condition", "text": [ "immunodeficiency" ], "offsets": [ [ 155, 171 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T15", "type": "Temporal", "text": [ "during the treatment period" ], "offsets": [ [ 193, 220 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T16", "type": "Procedure", "text": [ "immunosuppressive therapy" ], "offsets": [ [ 232, 257 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T17", "type": "Drug", "text": [ "oral steroid" ], "offsets": [ [ 259, 271 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T18", "type": "Condition", "text": [ "HIV" ], "offsets": [ [ 276, 279 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T20", "type": "Condition", "text": [ "congenital immune disease" ], "offsets": [ [ 324, 349 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T21", "type": "Scope", "text": [ "immunodeficiency and malignant tumors" ], "offsets": [ [ 155, 192 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T19", "type": "Observation", "text": [ "family members" ], "offsets": [ [ 304, 318 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T22", "type": "Drug", "text": [ "Nonspecific immunoglobulin" ], "offsets": [ [ 350, 376 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T23", "type": "Temporal", "text": [ "within one month" ], "offsets": [ [ 390, 406 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T24", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 407, 418 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T25", "type": "Value", "text": [ "=37.1<U+2103>" ], "offsets": [ [ 418, 431 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T26", "type": "Condition", "text": [ "infectious diseases" ], "offsets": [ [ 436, 455 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T27", "type": "Condition", "text": [ "thrombocytopenia" ], "offsets": [ [ 471, 487 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T28", "type": "Observation", "text": [ "history" ], "offsets": [ [ 460, 467 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T29", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 491, 496 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T30", "type": "Condition", "text": [ "thrombocytopenia" ], "offsets": [ [ 497, 513 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T31", "type": "Condition", "text": [ "respiratory disease" ], "offsets": [ [ 540, 559 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T32", "type": "Condition", "text": [ "acute infection" ], "offsets": [ [ 561, 576 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T33", "type": "Condition", "text": [ "chronic disease activity period" ], "offsets": [ [ 580, 611 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T34", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 612, 618 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T35", "type": "Condition", "text": [ "cardiovascular disease" ], "offsets": [ [ 619, 641 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T36", "type": "Condition", "text": [ "kidney disease" ], "offsets": [ [ 653, 667 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T37", "type": "Condition", "text": [ "nd ki", ", and c" ], "offsets": [ [ 650, 655 ], [ 667, 674 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T38", "type": "Condition", "text": [ "complications" ], "offsets": [ [ 673, 686 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T39", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 690, 698 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T40", "type": "Condition", "text": [ "us, suppur", "is\nother c" ], "offsets": [ [ 707, 717 ], [ 744, 754 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T41", "type": "Condition", "text": [ "ive and all", "is\nother c" ], "offsets": [ [ 719, 730 ], [ 744, 754 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T42", "type": "Condition", "text": [ "allergic dermatosis" ], "offsets": [ [ 727, 746 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T44", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 812, 819 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T45", "type": "Condition", "text": [ "adverse events" ], "offsets": [ [ 820, 834 ] ], "normalized": [] }, { "id": "NCT03519568_exc_T46", "type": "Procedure", "text": [ "inoculation of the upper dose of the vaccine" ], "offsets": [ [ 876, 920 ] ], "normalized": [] } ]

[]

[]

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[ { "id": "NCT03519568_inc_text", "type": "inclusion", "text": [ "aged = 6 months\nsign the informed consent form\nthe legal guardians participate in all the planned follow-up and be able to comply with all research procedures\nthe subjects have completed the basic immunization of 2 needle recombinant hepatitis B vaccine, there is no inoculation history of EV71 vaccine, and no history of EV71 infection\nthe last vaccination intervals = 14 days\ntemperature = 37<U+2103>\naged = 6 months\nsign the informed consent form\nthe legal guardians participate in all the planned follow-up and be able to comply with all research procedures\nthere is no inoculation history of EV71 vaccine, and there is no history of EV71 infection\nthe last vaccination intervals = 14 days\ntemperature = 37<U+2103>\naged = 8 months\nsign the informed consent form\nthe legal guardians participate in all the planned follow-up and be able to comply with all research procedures\nthere is no inoculation history of EV71 vaccine, and there is no history of EV71 infection\nthe last vaccination intervals = 14 days and the last attenuated live vaccine intervals=28days\ntemperature = 37<U+2103>\naged = 8 months\nsign the informed consent form\nthe legal guardians participate in all the planned follow-up and be able to comply with all research procedures\nthere is no inoculation history of EV71 vaccine, and there is no history of EV71 infection\nthe last vaccination intervals = 14 days and the last attenuated live vaccine intervals = 28 days\ntemperature = 37<U+2103>\n" ], "offsets": [ [ 0, 1462 ] ] } ]

[ { "id": "NCT03519568_inc_T1", "type": "Person", "text": [ "aged" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T2", "type": "Value", "text": [ "= 6 months" ], "offsets": [ [ 5, 15 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T6", "type": "Multiplier", "text": [ "2" ], "offsets": [ [ 213, 214 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T7", "type": "Drug", "text": [ "needle recombinant hepatitis B vaccine" ], "offsets": [ [ 215, 253 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T8", "type": "Negation", "text": [ "no" ], "offsets": [ [ 268, 270 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T9", "type": "Drug", "text": [ "EV71 vaccine" ], "offsets": [ [ 290, 302 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T10", "type": "Negation", "text": [ "no" ], "offsets": [ [ 308, 310 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T11", "type": "Observation", "text": [ "history" ], "offsets": [ [ 311, 318 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T12", "type": "Condition", "text": [ "EV71 infection" ], "offsets": [ [ 322, 336 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T13", "type": "Procedure", "text": [ "inoculation" ], "offsets": [ [ 267, 278 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T14", "type": "Observation", "text": [ "history" ], "offsets": [ [ 279, 286 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T5", "type": "Observation", "text": [ "last vaccination intervals" ], "offsets": [ [ 341, 367 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T15", "type": "Value", "text": [ "= 14 days" ], "offsets": [ [ 368, 377 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T16", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 378, 389 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T17", "type": "Value", "text": [ "= 37<U+2103>" ], "offsets": [ [ 390, 402 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T18", "type": "Person", "text": [ "aged" ], "offsets": [ [ 403, 407 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T19", "type": "Value", "text": [ "= 6 months" ], "offsets": [ [ 408, 418 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T22", "type": "Negation", "text": [ "no" ], "offsets": [ [ 575, 577 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T23", "type": "Procedure", "text": [ "inoculation" ], "offsets": [ [ 574, 585 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T24", "type": "Observation", "text": [ "history" ], "offsets": [ [ 586, 593 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T25", "type": "Drug", "text": [ "EV71 vaccine" ], "offsets": [ [ 597, 609 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T26", "type": "Negation", "text": [ "no" ], "offsets": [ [ 624, 626 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T27", "type": "Observation", "text": [ "history" ], "offsets": [ [ 627, 634 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T28", "type": "Condition", "text": [ "EV71 infection" ], "offsets": [ [ 638, 652 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T29", "type": "Observation", "text": [ "last vaccination intervals" ], "offsets": [ [ 657, 683 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T30", "type": "Value", "text": [ "= 14 days" ], "offsets": [ [ 684, 693 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T31", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 694, 705 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T32", "type": "Value", "text": [ "= 37<U+2103>" ], "offsets": [ [ 706, 718 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T33", "type": "Person", "text": [ "aged" ], "offsets": [ [ 719, 723 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T34", "type": "Value", "text": [ "= 8 months" ], "offsets": [ [ 724, 734 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T37", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 1064, 1075 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T38", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 1437, 1448 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T39", "type": "Value", "text": [ "= 37<U+2103>" ], "offsets": [ [ 1076, 1088 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T40", "type": "Value", "text": [ "= 37<U+2103>" ], "offsets": [ [ 1449, 1461 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T41", "type": "Person", "text": [ "aged" ], "offsets": [ [ 1089, 1093 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T42", "type": "Value", "text": [ "= 8 months" ], "offsets": [ [ 1094, 1104 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T45", "type": "Negation", "text": [ "no" ], "offsets": [ [ 891, 893 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T46", "type": "Negation", "text": [ "no" ], "offsets": [ [ 1261, 1263 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T47", "type": "Procedure", "text": [ "inoculation" ], "offsets": [ [ 890, 901 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T48", "type": "Procedure", "text": [ "inoculation" ], "offsets": [ [ 1260, 1271 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T49", "type": "Observation", "text": [ "history" ], "offsets": [ [ 902, 909 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T50", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1313, 1320 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T51", "type": "Drug", "text": [ "EV71 vaccine" ], "offsets": [ [ 913, 925 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T52", "type": "Drug", "text": [ "EV71 vaccine" ], "offsets": [ [ 1283, 1295 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T53", "type": "Negation", "text": [ "no" ], "offsets": [ [ 940, 942 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T54", "type": "Negation", "text": [ "no" ], "offsets": [ [ 1310, 1312 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T55", "type": "Observation", "text": [ "history" ], "offsets": [ [ 943, 950 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T56", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1313, 1320 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T57", "type": "Condition", "text": [ "EV71 infection" ], "offsets": [ [ 954, 968 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T58", "type": "Condition", "text": [ "EV71 infection" ], "offsets": [ [ 1324, 1338 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T59", "type": "Observation", "text": [ "last vaccination intervals" ], "offsets": [ [ 973, 999 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T60", "type": "Value", "text": [ "= 14 days" ], "offsets": [ [ 1000, 1009 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T61", "type": "Observation", "text": [ "last attenuated live vaccine intervals" ], "offsets": [ [ 1018, 1056 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T62", "type": "Value", "text": [ "=28days" ], "offsets": [ [ 1056, 1063 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T63", "type": "Value", "text": [ "= 28 days" ], "offsets": [ [ 1427, 1436 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T64", "type": "Observation", "text": [ "last attenuated live vaccine intervals" ], "offsets": [ [ 1388, 1426 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T65", "type": "Observation", "text": [ "last vaccination intervals" ], "offsets": [ [ 1343, 1369 ] ], "normalized": [] }, { "id": "NCT03519568_inc_T66", "type": "Value", "text": [ "= 14 days" ], "offsets": [ [ 1370, 1379 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03519568_inc_R1", "type": "Has_value", "arg1_id": "NCT03519568_inc_T1", "arg2_id": "NCT03519568_inc_T2", "normalized": [] }, { "id": "NCT03519568_inc_R2", "type": "Has_negation", "arg1_id": "NCT03519568_inc_T11", "arg2_id": "NCT03519568_inc_T10", "normalized": [] }, { "id": "NCT03519568_inc_R3", "type": "Has_negation", "arg1_id": "NCT03519568_inc_T13", "arg2_id": "NCT03519568_inc_T8", "normalized": [] }, { "id": "NCT03519568_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03519568_inc_T13", "arg2_id": "NCT03519568_inc_T14", "normalized": [] }, { "id": "NCT03519568_inc_R5", "type": "AND", "arg1_id": "NCT03519568_inc_T9", "arg2_id": "NCT03519568_inc_T13", "normalized": [] }, { "id": "NCT03519568_inc_R6", "type": "Has_multiplier", "arg1_id": "NCT03519568_inc_T7", "arg2_id": "NCT03519568_inc_T6", "normalized": [] }, { "id": "NCT03519568_inc_R7", "type": "Has_temporal", "arg1_id": "NCT03519568_inc_T12", "arg2_id": "NCT03519568_inc_T11", "normalized": [] }, { "id": "NCT03519568_inc_R8", "type": "Has_value", "arg1_id": "NCT03519568_inc_T5", "arg2_id": "NCT03519568_inc_T15", "normalized": [] }, { "id": "NCT03519568_inc_R9", "type": "Has_value", "arg1_id": "NCT03519568_inc_T16", "arg2_id": "NCT03519568_inc_T17", "normalized": [] }, { "id": "NCT03519568_inc_R10", "type": "Has_value", "arg1_id": "NCT03519568_inc_T18", "arg2_id": "NCT03519568_inc_T19", "normalized": [] }, { "id": "NCT03519568_inc_R11", "type": "Has_negation", "arg1_id": "NCT03519568_inc_T23", "arg2_id": "NCT03519568_inc_T22", "normalized": [] }, { "id": "NCT03519568_inc_R12", "type": "AND", "arg1_id": "NCT03519568_inc_T23", "arg2_id": "NCT03519568_inc_T25", "normalized": [] }, { "id": "NCT03519568_inc_R13", "type": "Has_negation", "arg1_id": "NCT03519568_inc_T28", "arg2_id": "NCT03519568_inc_T26", "normalized": [] }, { "id": "NCT03519568_inc_R14", "type": "Has_temporal", "arg1_id": "NCT03519568_inc_T28", "arg2_id": "NCT03519568_inc_T27", "normalized": [] }, { "id": "NCT03519568_inc_R15", "type": "Has_value", "arg1_id": "NCT03519568_inc_T29", "arg2_id": "NCT03519568_inc_T30", "normalized": [] }, { "id": "NCT03519568_inc_R16", "type": "Has_value", "arg1_id": "NCT03519568_inc_T31", "arg2_id": "NCT03519568_inc_T32", "normalized": [] }, { "id": "NCT03519568_inc_R17", "type": "Has_value", "arg1_id": "NCT03519568_inc_T33", "arg2_id": "NCT03519568_inc_T34", "normalized": [] }, { "id": "NCT03519568_inc_R18", "type": "Has_value", "arg1_id": "NCT03519568_inc_T37", "arg2_id": "NCT03519568_inc_T39", "normalized": [] }, { "id": "NCT03519568_inc_R19", "type": "Has_value", "arg1_id": "NCT03519568_inc_T38", "arg2_id": "NCT03519568_inc_T40", "normalized": [] }, { "id": "NCT03519568_inc_R20", "type": "Has_value", "arg1_id": "NCT03519568_inc_T41", "arg2_id": "NCT03519568_inc_T42", "normalized": [] }, { "id": "NCT03519568_inc_R21", "type": "Has_negation", "arg1_id": "NCT03519568_inc_T57", "arg2_id": "NCT03519568_inc_T53", "normalized": [] }, { "id": "NCT03519568_inc_R22", "type": "Has_negation", "arg1_id": "NCT03519568_inc_T58", "arg2_id": "NCT03519568_inc_T54", "normalized": [] }, { "id": "NCT03519568_inc_R23", "type": "Has_temporal", "arg1_id": "NCT03519568_inc_T57", "arg2_id": "NCT03519568_inc_T55", "normalized": [] }, { "id": "NCT03519568_inc_R24", "type": "Has_temporal", "arg1_id": "NCT03519568_inc_T58", "arg2_id": "NCT03519568_inc_T56", "normalized": [] }, { "id": "NCT03519568_inc_R25", "type": "Has_negation", "arg1_id": "NCT03519568_inc_T47", "arg2_id": "NCT03519568_inc_T45", "normalized": [] }, { "id": "NCT03519568_inc_R26", "type": "AND", "arg1_id": "NCT03519568_inc_T47", "arg2_id": "NCT03519568_inc_T51", "normalized": [] }, { "id": "NCT03519568_inc_R27", "type": "Has_temporal", "arg1_id": "NCT03519568_inc_T47", "arg2_id": "NCT03519568_inc_T49", "normalized": [] }, { "id": "NCT03519568_inc_R28", "type": "Has_temporal", "arg1_id": "NCT03519568_inc_T23", "arg2_id": "NCT03519568_inc_T24", "normalized": [] }, { "id": "NCT03519568_inc_R29", "type": "Has_negation", "arg1_id": "NCT03519568_inc_T48", "arg2_id": "NCT03519568_inc_T46", "normalized": [] }, { "id": "NCT03519568_inc_R30", "type": "AND", "arg1_id": "NCT03519568_inc_T48", "arg2_id": "NCT03519568_inc_T52", "normalized": [] }, { "id": "NCT03519568_inc_R31", "type": "Has_temporal", "arg1_id": "NCT03519568_inc_T48", "arg2_id": "NCT03519568_inc_T50", "normalized": [] }, { "id": "NCT03519568_inc_R32", "type": "Has_value", "arg1_id": "NCT03519568_inc_T59", "arg2_id": "NCT03519568_inc_T60", "normalized": [] }, { "id": "NCT03519568_inc_R33", "type": "Has_value", "arg1_id": "NCT03519568_inc_T61", "arg2_id": "NCT03519568_inc_T62", "normalized": [] }, { "id": "NCT03519568_inc_R34", "type": "Has_value", "arg1_id": "NCT03519568_inc_T64", "arg2_id": "NCT03519568_inc_T63", "normalized": [] }, { "id": "NCT03519568_inc_R35", "type": "Has_value", "arg1_id": "NCT03519568_inc_T65", "arg2_id": "NCT03519568_inc_T66", "normalized": [] } ]

[ { "id": "NCT03530124_exc_text", "type": "exclusion", "text": [ "Receipt of DTaP, IPV, PCV13, or Hib prior to enrollment. Previous administration of the first dose of HBV is permitted\nAnticipated receipt of any vaccine other than DTaP, IPV, HBV, PCV13, or Hib during the first 60 hours after randomization\nHistory of a severe allergic reaction (e.g. anaphylaxis) to a previous dose of any hepatitis B vaccine\nHistory of a severe allergic reaction (e.g. anaphylaxis) to any component of the vaccines used in the study including neomycin, yeast and polymyxin B\nHistory of latex allergy\nHistory of unstable progressive neurologic disorder of unknown cause\nKnown cause of apnea other than apnea of prematurity\nCyanotic heart disease (congenital or acquired)\nChild or parent/LAR is an immediate relative of study staff or an employee who is supervised by study staff.\nAny condition that would, in the opinion of the site investigator, place the participant at an unacceptable risk of injury or render the participant unable to meet the requirements of the protocol\n" ], "offsets": [ [ 0, 995 ] ] } ]

[ { "id": "NCT03530124_exc_T1", "type": "Drug", "text": [ "DTaP" ], "offsets": [ [ 11, 15 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T2", "type": "Drug", "text": [ "IPV" ], "offsets": [ [ 17, 20 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T3", "type": "Drug", "text": [ "PCV13" ], "offsets": [ [ 22, 27 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T4", "type": "Drug", "text": [ "Hib" ], "offsets": [ [ 32, 35 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T5", "type": "Temporal", "text": [ "prior to enrollment" ], "offsets": [ [ 36, 55 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T6", "type": "Reference_point", "text": [ "enrollment" ], "offsets": [ [ 45, 55 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T7", "type": "Scope", "text": [ "DTaP, IPV, PCV13, or Hib" ], "offsets": [ [ 11, 35 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T8", "type": "Drug", "text": [ "DTaP" ], "offsets": [ [ 165, 169 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T9", "type": "Drug", "text": [ "IPV" ], "offsets": [ [ 171, 174 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T10", "type": "Drug", "text": [ "HBV" ], "offsets": [ [ 176, 179 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T11", "type": "Drug", "text": [ "PCV13" ], "offsets": [ [ 181, 186 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T12", "type": "Drug", "text": [ "Hib" ], "offsets": [ [ 191, 194 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T13", "type": "Mood", "text": [ "Anticipated receipt" ], "offsets": [ [ 119, 138 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T14", "type": "Temporal", "text": [ "during the first 60 hours after randomization" ], "offsets": [ [ 195, 240 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T15", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 227, 240 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T16", "type": "Scope", "text": [ "DTaP, IPV, HBV, PCV13, or Hib" ], "offsets": [ [ 165, 194 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T17", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 254, 260 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T18", "type": "Condition", "text": [ "allergic reaction" ], "offsets": [ [ 261, 278 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T19", "type": "Condition", "text": [ "anaphylaxis" ], "offsets": [ [ 285, 296 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T20", "type": "Drug", "text": [ "hepatitis B vaccine" ], "offsets": [ [ 324, 343 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T21", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 303, 311 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T22", "type": "Scope", "text": [ "severe allergic reaction" ], "offsets": [ [ 254, 278 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T23", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 357, 363 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T24", "type": "Condition", "text": [ "allergic reaction" ], "offsets": [ [ 364, 381 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T25", "type": "Condition", "text": [ "anaphylaxis" ], "offsets": [ [ 388, 399 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T26", "type": "Drug", "text": [ "component of the vaccines used in the study" ], "offsets": [ [ 408, 451 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T27", "type": "Drug", "text": [ "neomycin" ], "offsets": [ [ 462, 470 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T28", "type": "Drug", "text": [ "polymyxin B" ], "offsets": [ [ 482, 493 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T29", "type": "Drug", "text": [ "yeast" ], "offsets": [ [ 472, 477 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T30", "type": "Scope", "text": [ "neomycin, yeast and polymyxin B" ], "offsets": [ [ 462, 493 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T31", "type": "Scope", "text": [ "severe allergic reaction" ], "offsets": [ [ 357, 381 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T32", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 511, 518 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T33", "type": "Drug", "text": [ "latex" ], "offsets": [ [ 505, 510 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T34", "type": "Observation", "text": [ "History" ], "offsets": [ [ 494, 501 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T35", "type": "Condition", "text": [ "progressive neurologic disorder" ], "offsets": [ [ 539, 570 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T36", "type": "Qualifier", "text": [ "unknown cause" ], "offsets": [ [ 574, 587 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T37", "type": "Qualifier", "text": [ "unstable" ], "offsets": [ [ 530, 538 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T38", "type": "Observation", "text": [ "History" ], "offsets": [ [ 519, 526 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T39", "type": "Condition", "text": [ "Known cause of apnea" ], "offsets": [ [ 588, 608 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T40", "type": "Condition", "text": [ "apnea of prematurity" ], "offsets": [ [ 620, 640 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T41", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 609, 619 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T42", "type": "Condition", "text": [ "Cyanotic heart disease" ], "offsets": [ [ 641, 663 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T43", "type": "Qualifier", "text": [ "congenital" ], "offsets": [ [ 665, 675 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T44", "type": "Qualifier", "text": [ "acquired" ], "offsets": [ [ 679, 687 ] ], "normalized": [] }, { "id": "NCT03530124_exc_T45", "type": "Scope", "text": [ "congenital or acquired" ], "offsets": [ [ 665, 687 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03530124_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03530124_exc_T7", "arg2_id": "NCT03530124_exc_T5", "normalized": [] }, { "id": "NCT03530124_exc_R2", "type": "Has_index", "arg1_id": "NCT03530124_exc_T14", "arg2_id": "NCT03530124_exc_T15", "normalized": [] }, { "id": "NCT03530124_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03530124_exc_T16", "arg2_id": "NCT03530124_exc_T14", "normalized": [] }, { "id": "NCT03530124_exc_R4", "type": "Has_mood", "arg1_id": "NCT03530124_exc_T16", "arg2_id": "NCT03530124_exc_T13", "normalized": [] }, { "id": "NCT03530124_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03530124_exc_T20", "arg2_id": "NCT03530124_exc_T21", "normalized": [] }, { "id": "NCT03530124_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03530124_exc_T18", "arg2_id": "NCT03530124_exc_T17", "normalized": [] }, { "id": "NCT03530124_exc_R7", "type": "Subsumes", "arg1_id": "NCT03530124_exc_T22", "arg2_id": "NCT03530124_exc_T19", "normalized": [] }, { "id": "NCT03530124_exc_R8", "type": "AND", "arg1_id": "NCT03530124_exc_T22", "arg2_id": "NCT03530124_exc_T20", "normalized": [] }, { "id": "NCT03530124_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03530124_exc_T24", "arg2_id": "NCT03530124_exc_T23", "normalized": [] }, { "id": "NCT03530124_exc_R10", "type": "Subsumes", "arg1_id": "NCT03530124_exc_T26", "arg2_id": "NCT03530124_exc_T30", "normalized": [] }, { "id": "NCT03530124_exc_R11", "type": "Subsumes", "arg1_id": "NCT03530124_exc_T31", "arg2_id": "NCT03530124_exc_T25", "normalized": [] }, { "id": "NCT03530124_exc_R12", "type": "AND", "arg1_id": "NCT03530124_exc_T31", "arg2_id": "NCT03530124_exc_T26", "normalized": [] }, { "id": "NCT03530124_exc_R13", "type": "AND", "arg1_id": "NCT03530124_exc_T32", "arg2_id": "NCT03530124_exc_T33", "normalized": [] }, { "id": "NCT03530124_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03530124_exc_T32", "arg2_id": "NCT03530124_exc_T34", "normalized": [] }, { "id": "NCT03530124_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT03530124_exc_T35", "arg2_id": "NCT03530124_exc_T36", "normalized": [] }, { "id": "NCT03530124_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT03530124_exc_T35", "arg2_id": "NCT03530124_exc_T37", "normalized": [] }, { "id": "NCT03530124_exc_R17", "type": "Has_temporal", "arg1_id": "NCT03530124_exc_T35", "arg2_id": "NCT03530124_exc_T38", "normalized": [] }, { "id": "NCT03530124_exc_R18", "type": "Has_negation", "arg1_id": "NCT03530124_exc_T40", "arg2_id": "NCT03530124_exc_T41", "normalized": [] }, { "id": "NCT03530124_exc_R19", "type": "AND", "arg1_id": "NCT03530124_exc_T39", "arg2_id": "NCT03530124_exc_T40", "normalized": [] }, { "id": "NCT03530124_exc_R20", "type": "Has_scope", "arg1_id": "NCT03530124_exc_T42", "arg2_id": "NCT03530124_exc_T45", "normalized": [] } ]

[ { "id": "NCT03530124_inc_text", "type": "inclusion", "text": [ "=32 weeks gestational age at birth\n=6 weeks postnatal age at randomization\nRemains hospitalized after birth (has never been discharged home)\nTreating clinician deems infant eligible to receive 2-month vaccines\nEnglish- or Spanish-speaking parent(s)/legally authorized representative(s) (LAR(s))\nNot planned for discharge within 60 hours of study entry\nThe parent/guardian must be willing and capable of providing permission for their child to participate through the written informed consent process\n" ], "offsets": [ [ 0, 500 ] ] } ]

[ { "id": "NCT03530124_inc_T1", "type": "Measurement", "text": [ "gestational age at birth" ], "offsets": [ [ 10, 34 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T2", "type": "Value", "text": [ "=32 weeks" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T3", "type": "Measurement", "text": [ "postnatal age" ], "offsets": [ [ 44, 57 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T4", "type": "Temporal", "text": [ "at randomization" ], "offsets": [ [ 58, 74 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T5", "type": "Value", "text": [ "=6 weeks" ], "offsets": [ [ 35, 43 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T6", "type": "Observation", "text": [ "hospitalized" ], "offsets": [ [ 83, 95 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T7", "type": "Temporal", "text": [ "after birth" ], "offsets": [ [ 96, 107 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T8", "type": "Reference_point", "text": [ "birth" ], "offsets": [ [ 102, 107 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T9", "type": "Mood", "text": [ "eligible" ], "offsets": [ [ 173, 181 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T10", "type": "Drug", "text": [ "2-month vaccines" ], "offsets": [ [ 193, 209 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T12", "type": "Mood", "text": [ "planned" ], "offsets": [ [ 299, 306 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T13", "type": "Procedure", "text": [ "discharge" ], "offsets": [ [ 311, 320 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T14", "type": "Temporal", "text": [ "within 60 hours of study entry" ], "offsets": [ [ 321, 351 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T15", "type": "Reference_point", "text": [ "study entry" ], "offsets": [ [ 340, 351 ] ], "normalized": [] }, { "id": "NCT03530124_inc_T16", "type": "Measurement", "text": [ "Not" ], "offsets": [ [ 295, 298 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03530124_inc_R1", "type": "Has_value", "arg1_id": "NCT03530124_inc_T1", "arg2_id": "NCT03530124_inc_T2", "normalized": [] }, { "id": "NCT03530124_inc_R2", "type": "Has_value", "arg1_id": "NCT03530124_inc_T3", "arg2_id": "NCT03530124_inc_T5", "normalized": [] }, { "id": "NCT03530124_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03530124_inc_T3", "arg2_id": "NCT03530124_inc_T4", "normalized": [] }, { "id": "NCT03530124_inc_R4", "type": "Has_index", "arg1_id": "NCT03530124_inc_T7", "arg2_id": "NCT03530124_inc_T8", "normalized": [] }, { "id": "NCT03530124_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03530124_inc_T6", "arg2_id": "NCT03530124_inc_T7", "normalized": [] }, { "id": "NCT03530124_inc_R6", "type": "Has_mood", "arg1_id": "NCT03530124_inc_T10", "arg2_id": "NCT03530124_inc_T9", "normalized": [] }, { "id": "NCT03530124_inc_R8", "type": "Has_mood", "arg1_id": "NCT03530124_inc_T13", "arg2_id": "NCT03530124_inc_T12", "normalized": [] }, { "id": "NCT03530124_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03530124_inc_T13", "arg2_id": "NCT03530124_inc_T14", "normalized": [] }, { "id": "NCT03530124_inc_R7", "type": "AND", "arg1_id": "NCT03530124_inc_T13", "arg2_id": "NCT03530124_inc_T16", "normalized": [] } ]

[ { "id": "NCT03532620_exc_text", "type": "exclusion", "text": [ "Past history of hypersensitivity to the study drug;\nDiagnosed diabetes;\nSevere liver disease (including ALT or AST=2.5-fold the normal upper limit), biliary obstruction;\nOngoing treatment with cyclosporine within 2 weeks;\nRenal dysfunction, including endogenous creatinine clearance male<120ml/min, female<105ml/min, serum creatinine=2mg/dl (186umol/L), Renal function progressive decline, GFR<30ml•min-1•1.73m-2;\nDiagnosed or past history of ASCVD (including ACS, SCAD, revascularization, ICM, ischemic stroke, TIA, PASD, etc.\nSBP=180mmHg, or DBP=110mmHg;\nOngoing treatment with Beta blockers, Diuretic;\nSecondary hypertension, including SAS, PA, RAS, pheochromocytoma, Cushing's syndrome, aorta diseases, drug induced hypertension;\nOngoing treatment with statins, fibrates, and/or cation exchange resins within 2 weeks;\nPancreatic disease;\nHistory of gastrectomy, short bowel syndrome;\nOngoing hormone replacement therapy;\nDiagnosed or suspected malignant tumor;\nFamilial hypercholesterolemia;\nAny diseases may limit the efficacy or safety of the study;\nPregnant or possibly pregnant woman, or breastfeeding woman, or woman who wishes to become pregnant during study participation;\nIFG impaired fast glucose, FPG fasting plasma glucose, IGT impaired glucose tolerance, OGTT oral glucose tolerance test, PG plasma glucose, HbA1C hemoglobin A1C, LDL-C low-density lipoprotein cholesterol, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure, ALT alanine aminotransferase, AST aspartate aminotransferase, GFR glomerular filtration rate, ASCVD arteriosclerotic cardiovascular disease, ACS acute coronary syndrome, SCAD stable coronary artery disease, ICM ischemic cardiomyopathy, TIA transient ischemic attack, PASD peripheral atherosclerotic disease, SAS sleep apnea syndrome, PA primary aldosteronism, RAS renal arterial stenosis\n" ], "offsets": [ [ 0, 1854 ] ] } ]

[ { "id": "NCT03532620_exc_T1", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 16, 32 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T2", "type": "Drug", "text": [ "study drug" ], "offsets": [ [ 40, 50 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T3", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 62, 70 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T4", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 79, 92 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T5", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 72, 78 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T6", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 111, 114 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T7", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 104, 107 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T8", "type": "Value", "text": [ "=2.5-fold the normal upper limit" ], "offsets": [ [ 114, 146 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T9", "type": "Condition", "text": [ "biliary obstruction" ], "offsets": [ [ 149, 168 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T10", "type": "Scope", "text": [ "ALT or AST" ], "offsets": [ [ 104, 114 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T11", "type": "Scope", "text": [ "Severe liver disease" ], "offsets": [ [ 72, 92 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T12", "type": "Drug", "text": [ "cyclosporine" ], "offsets": [ [ 193, 205 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T13", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 178, 187 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T14", "type": "Temporal", "text": [ "Ongoing" ], "offsets": [ [ 170, 177 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T15", "type": "Temporal", "text": [ "within 2 weeks" ], "offsets": [ [ 206, 220 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T16", "type": "Condition", "text": [ "Renal dysfunction" ], "offsets": [ [ 222, 239 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T17", "type": "Measurement", "text": [ "endogenous creatinine clearance" ], "offsets": [ [ 251, 282 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T18", "type": "Person", "text": [ "male" ], "offsets": [ [ 283, 287 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T19", "type": "Person", "text": [ "female" ], "offsets": [ [ 299, 305 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T20", "type": "Value", "text": [ "<105ml/min" ], "offsets": [ [ 305, 315 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T21", "type": "Value", "text": [ "<120ml/min" ], "offsets": [ [ 287, 297 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T22", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 317, 333 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T23", "type": "Value", "text": [ "=2mg/dl" ], "offsets": [ [ 333, 340 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T24", "type": "Value", "text": [ "186umol/L" ], "offsets": [ [ 342, 351 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T25", "type": "Measurement", "text": [ "Renal function" ], "offsets": [ [ 354, 368 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T26", "type": "Value", "text": [ "progressive decline" ], "offsets": [ [ 369, 388 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T27", "type": "Measurement", "text": [ "GFR" ], "offsets": [ [ 390, 393 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T28", "type": "Value", "text": [ "<30ml•min-1•1.73m-2" ], "offsets": [ [ 393, 412 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T29", "type": "Scope", "text": [ "male<120ml/min, female<105ml/min" ], "offsets": [ [ 283, 315 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T30", "type": "Scope", "text": [ "endogenous creatinine clearance male<120ml/min, female<105ml/min, serum creatinine=2mg/dl (186umol/L), Renal function progressive decline, GFR<30ml•min-1•1.73m-2" ], "offsets": [ [ 251, 412 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T31", "type": "Condition", "text": [ "ASCVD" ], "offsets": [ [ 443, 448 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T32", "type": "Condition", "text": [ "ACS" ], "offsets": [ [ 460, 463 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T33", "type": "Condition", "text": [ "SCAD" ], "offsets": [ [ 465, 469 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T34", "type": "Procedure", "text": [ "revascularization" ], "offsets": [ [ 471, 488 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T35", "type": "Condition", "text": [ "ICM" ], "offsets": [ [ 490, 493 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T36", "type": "Condition", "text": [ "ischemic stroke" ], "offsets": [ [ 495, 510 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T37", "type": "Condition", "text": [ "TIA" ], "offsets": [ [ 512, 515 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T38", "type": "Condition", "text": [ "PASD" ], "offsets": [ [ 517, 521 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T39", "type": "Scope", "text": [ "ACS, SCAD, revascularization, ICM, ischemic stroke, TIA, PASD" ], "offsets": [ [ 460, 521 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T40", "type": "Measurement", "text": [ "SBP" ], "offsets": [ [ 528, 531 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T41", "type": "Measurement", "text": [ "DBP" ], "offsets": [ [ 544, 547 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T42", "type": "Value", "text": [ "=180mmHg" ], "offsets": [ [ 531, 539 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T43", "type": "Value", "text": [ "=110mmHg" ], "offsets": [ [ 547, 555 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T44", "type": "Drug", "text": [ "Beta blockers" ], "offsets": [ [ 580, 593 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T45", "type": "Temporal", "text": [ "Ongoing" ], "offsets": [ [ 557, 564 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T46", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 565, 574 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T47", "type": "Drug", "text": [ "Diuretic" ], "offsets": [ [ 595, 603 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T48", "type": "Scope", "text": [ "Beta blockers, Diuretic" ], "offsets": [ [ 580, 603 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T49", "type": "Condition", "text": [ "Secondary hypertension" ], "offsets": [ [ 605, 627 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T50", "type": "Condition", "text": [ "SAS" ], "offsets": [ [ 639, 642 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T51", "type": "Condition", "text": [ "PA" ], "offsets": [ [ 644, 646 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T52", "type": "Condition", "text": [ "RAS" ], "offsets": [ [ 648, 651 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T53", "type": "Condition", "text": [ "pheochromocytoma" ], "offsets": [ [ 653, 669 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T54", "type": "Condition", "text": [ "Cushing's syndrome" ], "offsets": [ [ 671, 689 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T55", "type": "Condition", "text": [ "aorta diseases" ], "offsets": [ [ 691, 705 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T56", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 720, 732 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T57", "type": "Qualifier", "text": [ "drug induced" ], "offsets": [ [ 707, 719 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T58", "type": "Scope", "text": [ "SAS, PA, RAS, pheochromocytoma, Cushing's syndrome, aorta diseases, drug induced hypertension" ], "offsets": [ [ 639, 732 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T59", "type": "Drug", "text": [ "statins" ], "offsets": [ [ 757, 764 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T60", "type": "Drug", "text": [ "fibrates" ], "offsets": [ [ 766, 774 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T61", "type": "Temporal", "text": [ "Ongoing" ], "offsets": [ [ 734, 741 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T62", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 742, 751 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T63", "type": "Drug", "text": [ "cation exchange resins" ], "offsets": [ [ 783, 805 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T64", "type": "Temporal", "text": [ "within 2 weeks" ], "offsets": [ [ 806, 820 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T65", "type": "Scope", "text": [ "statins, fibrates, and/or cation exchange resins" ], "offsets": [ [ 757, 805 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T66", "type": "Condition", "text": [ "Pancreatic disease" ], "offsets": [ [ 822, 840 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T67", "type": "Procedure", "text": [ "gastrectomy" ], "offsets": [ [ 853, 864 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T68", "type": "Condition", "text": [ "short bowel syndrome" ], "offsets": [ [ 866, 886 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T69", "type": "Observation", "text": [ "History" ], "offsets": [ [ 842, 849 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T70", "type": "Scope", "text": [ "gastrectomy, short bowel syndrome" ], "offsets": [ [ 853, 886 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T71", "type": "Temporal", "text": [ "Ongoing" ], "offsets": [ [ 888, 895 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T72", "type": "Procedure", "text": [ "hormone replacement therapy" ], "offsets": [ [ 896, 923 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T73", "type": "Condition", "text": [ "malignant tumor" ], "offsets": [ [ 948, 963 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T74", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 938, 947 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T75", "type": "Mood", "text": [ "Diagnosed" ], "offsets": [ [ 925, 934 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T76", "type": "Scope", "text": [ "Diagnosed or suspected" ], "offsets": [ [ 925, 947 ] ], "normalized": [] }, { "id": "NCT03532620_exc_T77", "type": "Condition", "text": [ "Familial hypercholesterolemia" ], "offsets": [ [ 965, 994 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03532620_exc_R1", "type": "AND", "arg1_id": "NCT03532620_exc_T1", "arg2_id": "NCT03532620_exc_T2", "normalized": [] }, { "id": "NCT03532620_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03532620_exc_T4", "arg2_id": "NCT03532620_exc_T5", "normalized": [] }, { "id": "NCT03532620_exc_R3", "type": "Has_value", "arg1_id": "NCT03532620_exc_T10", "arg2_id": "NCT03532620_exc_T8", "normalized": [] }, { "id": "NCT03532620_exc_R4", "type": "Subsumes", "arg1_id": "NCT03532620_exc_T11", "arg2_id": "NCT03532620_exc_T10", "normalized": [] }, { "id": "NCT03532620_exc_R5", "type": "AND", "arg1_id": "NCT03532620_exc_T11", "arg2_id": "NCT03532620_exc_T9", "normalized": [] }, { "id": "NCT03532620_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03532620_exc_T13", "arg2_id": "NCT03532620_exc_T14", "normalized": [] }, { "id": "NCT03532620_exc_R7", "type": "AND", "arg1_id": "NCT03532620_exc_T13", "arg2_id": "NCT03532620_exc_T12", "normalized": [] }, { "id": "NCT03532620_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03532620_exc_T13", "arg2_id": "NCT03532620_exc_T15", "normalized": [] }, { "id": "NCT03532620_exc_R9", "type": "Has_value", "arg1_id": "NCT03532620_exc_T18", "arg2_id": "NCT03532620_exc_T21", "normalized": [] }, { "id": "NCT03532620_exc_R10", "type": "Has_value", "arg1_id": "NCT03532620_exc_T19", "arg2_id": "NCT03532620_exc_T20", "normalized": [] }, { "id": "NCT03532620_exc_R11", "type": "Subsumes", "arg1_id": "NCT03532620_exc_T23", "arg2_id": "NCT03532620_exc_T24", "normalized": [] }, { "id": "NCT03532620_exc_R12", "type": "Has_value", "arg1_id": "NCT03532620_exc_T22", "arg2_id": "NCT03532620_exc_T23", "normalized": [] }, { "id": "NCT03532620_exc_R13", "type": "Has_value", "arg1_id": "NCT03532620_exc_T25", "arg2_id": "NCT03532620_exc_T26", "normalized": [] }, { "id": "NCT03532620_exc_R14", "type": "Has_value", "arg1_id": "NCT03532620_exc_T27", "arg2_id": "NCT03532620_exc_T28", "normalized": [] }, { "id": "NCT03532620_exc_R15", "type": "Has_scope", "arg1_id": "NCT03532620_exc_T17", "arg2_id": "NCT03532620_exc_T29", "normalized": [] }, { "id": "NCT03532620_exc_R16", "type": "Subsumes", "arg1_id": "NCT03532620_exc_T16", "arg2_id": "NCT03532620_exc_T30", "normalized": [] }, { "id": "NCT03532620_exc_R17", "type": "Subsumes", "arg1_id": "NCT03532620_exc_T31", "arg2_id": "NCT03532620_exc_T39", "normalized": [] }, { "id": "NCT03532620_exc_R18", "type": "Has_value", "arg1_id": "NCT03532620_exc_T40", "arg2_id": "NCT03532620_exc_T42", "normalized": [] }, { "id": "NCT03532620_exc_R19", "type": "Has_value", "arg1_id": "NCT03532620_exc_T41", "arg2_id": "NCT03532620_exc_T43", "normalized": [] }, { "id": "NCT03532620_exc_R20", "type": "Has_temporal", "arg1_id": "NCT03532620_exc_T46", "arg2_id": "NCT03532620_exc_T45", "normalized": [] }, { "id": "NCT03532620_exc_R21", "type": "Has_scope", "arg1_id": "NCT03532620_exc_T46", "arg2_id": "NCT03532620_exc_T48", "normalized": [] }, { "id": "NCT03532620_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT03532620_exc_T56", "arg2_id": "NCT03532620_exc_T57", "normalized": [] }, { "id": "NCT03532620_exc_R23", "type": "Subsumes", "arg1_id": "NCT03532620_exc_T49", "arg2_id": "NCT03532620_exc_T58", "normalized": [] }, { "id": "NCT03532620_exc_R24", "type": "Has_temporal", "arg1_id": "NCT03532620_exc_T62", "arg2_id": "NCT03532620_exc_T61", "normalized": [] }, { "id": "NCT03532620_exc_R25", "type": "Has_scope", "arg1_id": "NCT03532620_exc_T62", "arg2_id": "NCT03532620_exc_T65", "normalized": [] }, { "id": "NCT03532620_exc_R26", "type": "Has_temporal", "arg1_id": "NCT03532620_exc_T62", "arg2_id": "NCT03532620_exc_T64", "normalized": [] }, { "id": "NCT03532620_exc_R27", "type": "Has_temporal", "arg1_id": "NCT03532620_exc_T70", "arg2_id": "NCT03532620_exc_T69", "normalized": [] }, { "id": "NCT03532620_exc_R28", "type": "Has_temporal", "arg1_id": "NCT03532620_exc_T72", "arg2_id": "NCT03532620_exc_T71", "normalized": [] }, { "id": "NCT03532620_exc_R29", "type": "Has_scope", "arg1_id": "NCT03532620_exc_T73", "arg2_id": "NCT03532620_exc_T76", "normalized": [] } ]

[ { "id": "NCT03532620_inc_text", "type": "inclusion", "text": [ "Age 18-80 years old;\nIFG: 5.6mmol/L (100mg/dl)=FPG<7.0mmol/L (126mg/dl), or IGT: 7.8mmol/L (140mg/dl)=OGTT 2-h PG<11.1mmol/L (200mg/dl), or HbA1C 5.7-6.4% (39-47mmol/mol);\n2.6mmol/L (100mg/dl)=LDL-C=5.2mmol/L (200mg/dl), and TG<5.7mmol/L (500mg/dl);\n130mmHg=SBP<180mmHg, or 80mmHg=DBP<110mmHg or ongoing anti-hypertensive therapy;\nPatients volunteered for the study and signed informed consent.\n" ], "offsets": [ [ 0, 395 ] ] } ]

[ { "id": "NCT03532620_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T2", "type": "Value", "text": [ "18-80 years old" ], "offsets": [ [ 4, 19 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T3", "type": "Condition", "text": [ "IFG" ], "offsets": [ [ 21, 24 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T4", "type": "Value", "text": [ "5.6mmol/L" ], "offsets": [ [ 26, 35 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T5", "type": "Measurement", "text": [ "FPG" ], "offsets": [ [ 47, 50 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T6", "type": "Value", "text": [ "100mg/dl" ], "offsets": [ [ 37, 45 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T7", "type": "Value", "text": [ "<7.0mmol/L" ], "offsets": [ [ 50, 60 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T8", "type": "Value", "text": [ "126mg/dl" ], "offsets": [ [ 62, 70 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T9", "type": "Condition", "text": [ "IGT" ], "offsets": [ [ 76, 79 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T10", "type": "Value", "text": [ "7.8mmol/L" ], "offsets": [ [ 81, 90 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T11", "type": "Value", "text": [ "140mg/dl" ], "offsets": [ [ 92, 100 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T12", "type": "Measurement", "text": [ "OGTT 2-h PG" ], "offsets": [ [ 102, 113 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T13", "type": "Measurement", "text": [ "HbA1C" ], "offsets": [ [ 140, 145 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T14", "type": "Value", "text": [ "5.7-6.4%" ], "offsets": [ [ 146, 154 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T15", "type": "Value", "text": [ "39-47mmol/mol" ], "offsets": [ [ 156, 169 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T16", "type": "Value", "text": [ "<11.1mmol/L" ], "offsets": [ [ 113, 124 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T17", "type": "Value", "text": [ "200mg/dl" ], "offsets": [ [ 126, 134 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T18", "type": "Value", "text": [ "2.6mmol/L" ], "offsets": [ [ 172, 181 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T19", "type": "Value", "text": [ "100mg/dl" ], "offsets": [ [ 183, 191 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T20", "type": "Measurement", "text": [ "LDL-C" ], "offsets": [ [ 193, 198 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T21", "type": "Value", "text": [ "5.2mmol/L" ], "offsets": [ [ 199, 208 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T22", "type": "Value", "text": [ "200mg/dl" ], "offsets": [ [ 210, 218 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T23", "type": "Measurement", "text": [ "TG" ], "offsets": [ [ 225, 227 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T24", "type": "Value", "text": [ "<5.7mmol/L" ], "offsets": [ [ 227, 237 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T25", "type": "Value", "text": [ "500mg/dl" ], "offsets": [ [ 239, 247 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T26", "type": "Value", "text": [ "130mmHg" ], "offsets": [ [ 250, 257 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T27", "type": "Measurement", "text": [ "SBP" ], "offsets": [ [ 258, 261 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T28", "type": "Value", "text": [ "<180mmHg" ], "offsets": [ [ 261, 269 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T29", "type": "Value", "text": [ "80mmHg=" ], "offsets": [ [ 274, 281 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T30", "type": "Measurement", "text": [ "DBP" ], "offsets": [ [ 281, 284 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T31", "type": "Value", "text": [ "<110mmHg" ], "offsets": [ [ 284, 292 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T32", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 296, 303 ] ], "normalized": [] }, { "id": "NCT03532620_inc_T33", "type": "Procedure", "text": [ "anti-hypertensive therapy" ], "offsets": [ [ 304, 329 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03532620_inc_R1", "type": "Has_value", "arg1_id": "NCT03532620_inc_T1", "arg2_id": "NCT03532620_inc_T2", "normalized": [] }, { "id": "NCT03532620_inc_R2", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T4", "arg2_id": "NCT03532620_inc_T6", "normalized": [] }, { "id": "NCT03532620_inc_R3", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T7", "arg2_id": "NCT03532620_inc_T8", "normalized": [] }, { "id": "NCT03532620_inc_R4", "type": "Has_value", "arg1_id": "NCT03532620_inc_T5", "arg2_id": "NCT03532620_inc_T4", "normalized": [] }, { "id": "NCT03532620_inc_R5", "type": "Has_value", "arg1_id": "NCT03532620_inc_T5", "arg2_id": "NCT03532620_inc_T7", "normalized": [] }, { "id": "NCT03532620_inc_R6", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T14", "arg2_id": "NCT03532620_inc_T15", "normalized": [] }, { "id": "NCT03532620_inc_R7", "type": "Has_value", "arg1_id": "NCT03532620_inc_T13", "arg2_id": "NCT03532620_inc_T14", "normalized": [] }, { "id": "NCT03532620_inc_R8", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T16", "arg2_id": "NCT03532620_inc_T17", "normalized": [] }, { "id": "NCT03532620_inc_R9", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T10", "arg2_id": "NCT03532620_inc_T11", "normalized": [] }, { "id": "NCT03532620_inc_R10", "type": "Has_value", "arg1_id": "NCT03532620_inc_T12", "arg2_id": "NCT03532620_inc_T10", "normalized": [] }, { "id": "NCT03532620_inc_R11", "type": "Has_value", "arg1_id": "NCT03532620_inc_T12", "arg2_id": "NCT03532620_inc_T16", "normalized": [] }, { "id": "NCT03532620_inc_R12", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T3", "arg2_id": "NCT03532620_inc_T5", "normalized": [] }, { "id": "NCT03532620_inc_R13", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T9", "arg2_id": "NCT03532620_inc_T12", "normalized": [] }, { "id": "NCT03532620_inc_R14", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T21", "arg2_id": "NCT03532620_inc_T22", "normalized": [] }, { "id": "NCT03532620_inc_R15", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T18", "arg2_id": "NCT03532620_inc_T19", "normalized": [] }, { "id": "NCT03532620_inc_R16", "type": "Subsumes", "arg1_id": "NCT03532620_inc_T24", "arg2_id": "NCT03532620_inc_T25", "normalized": [] }, { "id": "NCT03532620_inc_R17", "type": "Has_value", "arg1_id": "NCT03532620_inc_T23", "arg2_id": "NCT03532620_inc_T24", "normalized": [] }, { "id": "NCT03532620_inc_R18", "type": "Has_value", "arg1_id": "NCT03532620_inc_T20", "arg2_id": "NCT03532620_inc_T18", "normalized": [] }, { "id": "NCT03532620_inc_R19", "type": "Has_value", "arg1_id": "NCT03532620_inc_T20", "arg2_id": "NCT03532620_inc_T21", "normalized": [] }, { "id": "NCT03532620_inc_R20", "type": "Has_value", "arg1_id": "NCT03532620_inc_T27", "arg2_id": "NCT03532620_inc_T26", "normalized": [] }, { "id": "NCT03532620_inc_R21", "type": "Has_value", "arg1_id": "NCT03532620_inc_T27", "arg2_id": "NCT03532620_inc_T28", "normalized": [] }, { "id": "NCT03532620_inc_R22", "type": "Has_value", "arg1_id": "NCT03532620_inc_T30", "arg2_id": "NCT03532620_inc_T29", "normalized": [] }, { "id": "NCT03532620_inc_R23", "type": "Has_value", "arg1_id": "NCT03532620_inc_T30", "arg2_id": "NCT03532620_inc_T31", "normalized": [] }, { "id": "NCT03532620_inc_R24", "type": "Has_temporal", "arg1_id": "NCT03532620_inc_T33", "arg2_id": "NCT03532620_inc_T32", "normalized": [] } ]

[ { "id": "NCT03536520_exc_text", "type": "exclusion", "text": [ "Any active respiratory, cardiovascular or other disease requiring regular treatment or being otherwise relevant for tolerance of hypoxia or altitude exposure.\nAny condition that may interfere with protocol compliance including current heavy smoking (>20 cigarettes per day or >20 pack-years with active smoking during the last 10 years), regular use of alcohol.\nAllergy to acetazolamide and other sulfonamides.\n" ], "offsets": [ [ 0, 411 ] ] } ]

[ { "id": "NCT03536520_exc_T1", "type": "Condition", "text": [ "respiratory", "disease" ], "offsets": [ [ 11, 22 ], [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T2", "type": "Condition", "text": [ "cardiovascular", "disease" ], "offsets": [ [ 24, 38 ], [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T3", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T4", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 42, 47 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T5", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 4, 10 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T6", "type": "Scope", "text": [ "respiratory, cardiovascular or other disease" ], "offsets": [ [ 11, 55 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T7", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 74, 83 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T8", "type": "Qualifier", "text": [ "regular" ], "offsets": [ [ 66, 73 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T9", "type": "Condition", "text": [ "tolerance" ], "offsets": [ [ 116, 125 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T10", "type": "Condition", "text": [ "hypoxia" ], "offsets": [ [ 129, 136 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T11", "type": "Mood", "text": [ "relevant for" ], "offsets": [ [ 103, 115 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T12", "type": "Observation", "text": [ "altitude exposure" ], "offsets": [ [ 140, 157 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T13", "type": "Scope", "text": [ "hypoxia or altitude exposure" ], "offsets": [ [ 129, 157 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T15", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 362, 369 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T16", "type": "Drug", "text": [ "acetazolamide" ], "offsets": [ [ 373, 386 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T17", "type": "Drug", "text": [ "sulfonamides" ], "offsets": [ [ 397, 409 ] ], "normalized": [] }, { "id": "NCT03536520_exc_T18", "type": "Scope", "text": [ "acetazolamide and other sulfonamides" ], "offsets": [ [ 373, 409 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03536520_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03536520_exc_T3", "arg2_id": "NCT03536520_exc_T4", "normalized": [] }, { "id": "NCT03536520_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03536520_exc_T6", "arg2_id": "NCT03536520_exc_T5", "normalized": [] }, { "id": "NCT03536520_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03536520_exc_T7", "arg2_id": "NCT03536520_exc_T8", "normalized": [] }, { "id": "NCT03536520_exc_R4", "type": "Has_scope", "arg1_id": "NCT03536520_exc_T9", "arg2_id": "NCT03536520_exc_T13", "normalized": [] }, { "id": "NCT03536520_exc_R5", "type": "Has_mood", "arg1_id": "NCT03536520_exc_T9", "arg2_id": "NCT03536520_exc_T11", "normalized": [] }, { "id": "NCT03536520_exc_R6", "type": "AND", "arg1_id": "NCT03536520_exc_T6", "arg2_id": "NCT03536520_exc_T7", "normalized": [] }, { "id": "NCT03536520_exc_R7", "type": "Has_scope", "arg1_id": "NCT03536520_exc_T15", "arg2_id": "NCT03536520_exc_T18", "normalized": [] } ]

[ { "id": "NCT03536520_inc_text", "type": "inclusion", "text": [ "Healthy men and women, age 40-75 yrs, without any disease and need of medication.\nBorn, raised and currently living at low altitude (<800m).\nWritten informed consent.\nKyrgyz ethnicity\n" ], "offsets": [ [ 0, 184 ] ] } ]

[ { "id": "NCT03536520_inc_T1", "type": "Person", "text": [ "men" ], "offsets": [ [ 8, 11 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 16, 21 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 23, 26 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T4", "type": "Value", "text": [ "40-75 yr" ], "offsets": [ [ 27, 35 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T5", "type": "Qualifier", "text": [ "Healthy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T6", "type": "Negation", "text": [ "without" ], "offsets": [ [ 38, 45 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T7", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 50, 57 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T8", "type": "Qualifier", "text": [ "any" ], "offsets": [ [ 46, 49 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T9", "type": "Procedure", "text": [ "medication" ], "offsets": [ [ 70, 80 ] ], "normalized": [] }, { "id": "NCT03536520_inc_T10", "type": "Scope", "text": [ "men and women," ], "offsets": [ [ 8, 22 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03536520_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03536520_inc_T7", "arg2_id": "NCT03536520_inc_T8", "normalized": [] }, { "id": "NCT03536520_inc_R2", "type": "Has_negation", "arg1_id": "NCT03536520_inc_T7", "arg2_id": "NCT03536520_inc_T6", "normalized": [] }, { "id": "NCT03536520_inc_R3", "type": "Has_value", "arg1_id": "NCT03536520_inc_T3", "arg2_id": "NCT03536520_inc_T4", "normalized": [] }, { "id": "NCT03536520_inc_R4", "type": "Has_value", "arg1_id": "NCT03536520_inc_T3", "arg2_id": "NCT03536520_inc_T4", "normalized": [] }, { "id": "NCT03536520_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03536520_inc_T10", "arg2_id": "NCT03536520_inc_T5", "normalized": [] }, { "id": "NCT03536520_inc_R6", "type": "Has_negation", "arg1_id": "NCT03536520_inc_T9", "arg2_id": "NCT03536520_inc_T6", "normalized": [] } ]

[ { "id": "NCT03537924_exc_text", "type": "exclusion", "text": [ "Any active respiratory, cardiovascular or other disease requiring regular treatment or being otherwise relevant for tolerance of hypoxia or altitude exposure.\nAny condition that may interfere with protocol compliance including current heavy smoking (>20 cigarettes per day or >20 pack-years with active smoking during the last 10 years), regular use of alcohol.\nAllergy to acetazolamide and other sulfonamides.\n" ], "offsets": [ [ 0, 411 ] ] } ]

[ { "id": "NCT03537924_exc_T1", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 42, 47 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T2", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T3", "type": "Condition", "text": [ "cardiovascular", "disease" ], "offsets": [ [ 24, 38 ], [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T4", "type": "Condition", "text": [ "respiratory", "disease" ], "offsets": [ [ 11, 22 ], [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T5", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 4, 10 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T6", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 56, 65 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T7", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 74, 83 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T8", "type": "Mood", "text": [ "relevant", "being" ], "offsets": [ [ 103, 111 ], [ 87, 92 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T9", "type": "Condition", "text": [ "tolerance" ], "offsets": [ [ 116, 125 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T10", "type": "Condition", "text": [ "hypoxia" ], "offsets": [ [ 129, 136 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T11", "type": "Condition", "text": [ "altitude exposure" ], "offsets": [ [ 140, 157 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T12", "type": "Scope", "text": [ "hypoxia or altitude exposure" ], "offsets": [ [ 129, 157 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T13", "type": "Scope", "text": [ "respiratory, cardiovascular or other disease" ], "offsets": [ [ 11, 55 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T14", "type": "Condition", "text": [ "heavy smoking" ], "offsets": [ [ 235, 248 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T15", "type": "Measurement", "text": [ "cigarettes per day" ], "offsets": [ [ 254, 272 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T16", "type": "Measurement", "text": [ "pack-years" ], "offsets": [ [ 280, 290 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T17", "type": "Condition", "text": [ "active smoking" ], "offsets": [ [ 296, 310 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T18", "type": "Temporal", "text": [ "during the last 10 years" ], "offsets": [ [ 311, 335 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T19", "type": "Value", "text": [ ">20" ], "offsets": [ [ 250, 253 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T20", "type": "Value", "text": [ ">20" ], "offsets": [ [ 276, 279 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T21", "type": "Scope", "text": [ ">20 cigarettes per day or >20 pack-years with active smoking during the last 10 years" ], "offsets": [ [ 250, 335 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T22", "type": "Condition", "text": [ "regular use of alcohol" ], "offsets": [ [ 338, 360 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T23", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 362, 369 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T24", "type": "Drug", "text": [ "acetazolamide" ], "offsets": [ [ 373, 386 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T25", "type": "Drug", "text": [ "sulfonamides" ], "offsets": [ [ 397, 409 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T26", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 391, 396 ] ], "normalized": [] }, { "id": "NCT03537924_exc_T27", "type": "Scope", "text": [ "acetazolamide and other sulfonamides" ], "offsets": [ [ 373, 409 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03537924_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03537924_exc_T2", "arg2_id": "NCT03537924_exc_T1", "normalized": [] }, { "id": "NCT03537924_exc_R2", "type": "Has_mood", "arg1_id": "NCT03537924_exc_T7", "arg2_id": "NCT03537924_exc_T6", "normalized": [] }, { "id": "NCT03537924_exc_R3", "type": "Has_mood", "arg1_id": "NCT03537924_exc_T9", "arg2_id": "NCT03537924_exc_T8", "normalized": [] }, { "id": "NCT03537924_exc_R4", "type": "Has_scope", "arg1_id": "NCT03537924_exc_T9", "arg2_id": "NCT03537924_exc_T12", "normalized": [] }, { "id": "NCT03537924_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03537924_exc_T13", "arg2_id": "NCT03537924_exc_T5", "normalized": [] }, { "id": "NCT03537924_exc_R6", "type": "AND", "arg1_id": "NCT03537924_exc_T13", "arg2_id": "NCT03537924_exc_T7", "normalized": [] }, { "id": "NCT03537924_exc_R7", "type": "Has_scope", "arg1_id": "NCT03537924_exc_T13", "arg2_id": "NCT03537924_exc_T12", "normalized": [] }, { "id": "NCT03537924_exc_R8", "type": "Has_value", "arg1_id": "NCT03537924_exc_T15", "arg2_id": "NCT03537924_exc_T19", "normalized": [] }, { "id": "NCT03537924_exc_R9", "type": "Has_value", "arg1_id": "NCT03537924_exc_T16", "arg2_id": "NCT03537924_exc_T20", "normalized": [] }, { "id": "NCT03537924_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03537924_exc_T17", "arg2_id": "NCT03537924_exc_T18", "normalized": [] }, { "id": "NCT03537924_exc_R11", "type": "Subsumes", "arg1_id": "NCT03537924_exc_T14", "arg2_id": "NCT03537924_exc_T21", "normalized": [] }, { "id": "NCT03537924_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03537924_exc_T25", "arg2_id": "NCT03537924_exc_T26", "normalized": [] }, { "id": "NCT03537924_exc_R13", "type": "Has_scope", "arg1_id": "NCT03537924_exc_T23", "arg2_id": "NCT03537924_exc_T27", "normalized": [] } ]

[ { "id": "NCT03537924_inc_text", "type": "inclusion", "text": [ "Healthy men and women, age 40-75 yrs, without any disease and need of medication.\nBorn, raised and currently living at low altitude (<800m).\nWritten informed consent.\nKyrgyz ethnicity\n" ], "offsets": [ [ 0, 184 ] ] } ]

[ { "id": "NCT03537924_inc_T1", "type": "Observation", "text": [ "Healthy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T2", "type": "Person", "text": [ "men" ], "offsets": [ [ 8, 11 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T3", "type": "Person", "text": [ "women" ], "offsets": [ [ 16, 21 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 23, 26 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T5", "type": "Value", "text": [ "40-75 yrs" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T6", "type": "Negation", "text": [ "without" ], "offsets": [ [ 38, 45 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T7", "type": "Condition", "text": [ "any disease" ], "offsets": [ [ 46, 57 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T8", "type": "Mood", "text": [ "need of" ], "offsets": [ [ 62, 69 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T9", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 70, 80 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T10", "type": "Scope", "text": [ "any disease and need of medication" ], "offsets": [ [ 46, 80 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T11", "type": "Observation", "text": [ "living at low altitude" ], "offsets": [ [ 109, 131 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T12", "type": "Observation", "text": [ "iving at", "800m)" ], "offsets": [ [ 110, 118 ], [ 134, 139 ] ], "normalized": [] }, { "id": "NCT03537924_inc_T14", "type": "Person", "text": [ "Kyrgyz ethnicity" ], "offsets": [ [ 167, 183 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03537924_inc_R1", "type": "Has_value", "arg1_id": "NCT03537924_inc_T4", "arg2_id": "NCT03537924_inc_T5", "normalized": [] }, { "id": "NCT03537924_inc_R2", "type": "Has_mood", "arg1_id": "NCT03537924_inc_T9", "arg2_id": "NCT03537924_inc_T8", "normalized": [] }, { "id": "NCT03537924_inc_R3", "type": "Has_negation", "arg1_id": "NCT03537924_inc_T10", "arg2_id": "NCT03537924_inc_T6", "normalized": [] }, { "id": "NCT03537924_inc_R4", "type": "Subsumes", "arg1_id": "NCT03537924_inc_T11", "arg2_id": "NCT03537924_inc_T12", "normalized": [] } ]

[ { "id": "NCT03539718_exc_text", "type": "exclusion", "text": [ "Patients with intercurrent infections.\nPatients with sepsis.\nPatients receiving drugs affecting immune system like immunosuppressive drugs.\nPatients on antibiotics.\n" ], "offsets": [ [ 0, 165 ] ] } ]

[ { "id": "NCT03539718_exc_T1", "type": "Condition", "text": [ "intercurrent infections" ], "offsets": [ [ 14, 37 ] ], "normalized": [] }, { "id": "NCT03539718_exc_T2", "type": "Condition", "text": [ "sepsis" ], "offsets": [ [ 53, 59 ] ], "normalized": [] }, { "id": "NCT03539718_exc_T3", "type": "Drug", "text": [ "drugs affecting immune system" ], "offsets": [ [ 80, 109 ] ], "normalized": [] }, { "id": "NCT03539718_exc_T4", "type": "Drug", "text": [ "immunosuppressive drugs" ], "offsets": [ [ 115, 138 ] ], "normalized": [] }, { "id": "NCT03539718_exc_T5", "type": "Drug", "text": [ "antibiotics" ], "offsets": [ [ 152, 163 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03539718_exc_R1", "type": "Subsumes", "arg1_id": "NCT03539718_exc_T3", "arg2_id": "NCT03539718_exc_T4", "normalized": [] } ]

[ { "id": "NCT03539718_inc_text", "type": "inclusion", "text": [ "Patients on regular hemodialysis 3sessions/wk.\nRecent catheter insertion at beginning of the study.\nBoth males and females.\nAge group = 18 ys.\n" ], "offsets": [ [ 0, 143 ] ] } ]

[ { "id": "NCT03539718_inc_T1", "type": "Procedure", "text": [ "regular hemodialysis" ], "offsets": [ [ 12, 32 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T2", "type": "Multiplier", "text": [ "3sessions/wk" ], "offsets": [ [ 33, 45 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T3", "type": "Procedure", "text": [ "catheter insertion" ], "offsets": [ [ 54, 72 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T4", "type": "Temporal", "text": [ "at beginning of the study" ], "offsets": [ [ 73, 98 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T5", "type": "Temporal", "text": [ "Recent" ], "offsets": [ [ 47, 53 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T6", "type": "Reference_point", "text": [ "beginning of the study" ], "offsets": [ [ 76, 98 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T7", "type": "Person", "text": [ "males" ], "offsets": [ [ 105, 110 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T8", "type": "Person", "text": [ "females" ], "offsets": [ [ 115, 122 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T9", "type": "Person", "text": [ "Age group" ], "offsets": [ [ 124, 133 ] ], "normalized": [] }, { "id": "NCT03539718_inc_T10", "type": "Value", "text": [ "= 18 ys" ], "offsets": [ [ 134, 141 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03539718_inc_R1", "type": "Has_multiplier", "arg1_id": "NCT03539718_inc_T1", "arg2_id": "NCT03539718_inc_T2", "normalized": [] }, { "id": "NCT03539718_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03539718_inc_T3", "arg2_id": "NCT03539718_inc_T4", "normalized": [] }, { "id": "NCT03539718_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03539718_inc_T3", "arg2_id": "NCT03539718_inc_T5", "normalized": [] }, { "id": "NCT03539718_inc_R4", "type": "Has_index", "arg1_id": "NCT03539718_inc_T4", "arg2_id": "NCT03539718_inc_T6", "normalized": [] }, { "id": "NCT03539718_inc_R5", "type": "Has_value", "arg1_id": "NCT03539718_inc_T9", "arg2_id": "NCT03539718_inc_T10", "normalized": [] } ]

[ { "id": "NCT03541980_exc_text", "type": "exclusion", "text": [ "Patient with fever (38C or 100.4F)\nPatient less than age 4 years\nPatient greater than age 16 years\nPatient with hypersensitivity/allergy to either morphine, NSAIDs, or acetaminophen\nPatient received acetaminophen within the past 4 hours\nPatient with known liver disease or renal disease\nPatient not requiring IV morphine (pain score 5/10 or less)\nPatient enrolled in the study within the past 72 hours\n" ], "offsets": [ [ 0, 402 ] ] } ]

[ { "id": "NCT03541980_exc_T1", "type": "Condition", "text": [ "fever" ], "offsets": [ [ 13, 18 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T2", "type": "Value", "text": [ "38C" ], "offsets": [ [ 20, 23 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T3", "type": "Value", "text": [ "100.4F" ], "offsets": [ [ 27, 33 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T4", "type": "Scope", "text": [ "38C or 100.4F" ], "offsets": [ [ 20, 33 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T5", "type": "Value", "text": [ "ess than", " year" ], "offsets": [ [ 44, 52 ], [ 58, 63 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T6", "type": "Person", "text": [ "age" ], "offsets": [ [ 53, 56 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T7", "type": "Value", "text": [ "eater than a", " years\n" ], "offsets": [ [ 75, 87 ], [ 92, 99 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T8", "type": "Person", "text": [ "age" ], "offsets": [ [ 86, 89 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T9", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 112, 128 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T10", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 129, 136 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T11", "type": "Drug", "text": [ "morphine" ], "offsets": [ [ 147, 155 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T12", "type": "Drug", "text": [ "NSAIDs" ], "offsets": [ [ 157, 163 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T13", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 168, 181 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T14", "type": "Scope", "text": [ "morphine, NSAIDs, or acetaminophen" ], "offsets": [ [ 147, 181 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T15", "type": "Scope", "text": [ "hypersensitivity/allergy" ], "offsets": [ [ 112, 136 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T16", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 199, 212 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T17", "type": "Temporal", "text": [ "within the past 4 hours" ], "offsets": [ [ 213, 236 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T18", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 256, 269 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T19", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 273, 286 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T20", "type": "Negation", "text": [ "not" ], "offsets": [ [ 295, 298 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T21", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 299, 308 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T22", "type": "Drug", "text": [ "IV morphine" ], "offsets": [ [ 309, 320 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T23", "type": "Measurement", "text": [ "pain score" ], "offsets": [ [ 322, 332 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T24", "type": "Value", "text": [ "5/10 or less" ], "offsets": [ [ 333, 345 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T25", "type": "Scope", "text": [ "not requiring IV morphine" ], "offsets": [ [ 295, 320 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T26", "type": "Scope", "text": [ "pain score 5/10 or less" ], "offsets": [ [ 322, 345 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T27", "type": "Observation", "text": [ "enrolled in the study" ], "offsets": [ [ 355, 376 ] ], "normalized": [] }, { "id": "NCT03541980_exc_T28", "type": "Temporal", "text": [ "within the past 72 hours" ], "offsets": [ [ 377, 401 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03541980_exc_R1", "type": "Has_scope", "arg1_id": "NCT03541980_exc_T1", "arg2_id": "NCT03541980_exc_T4", "normalized": [] }, { "id": "NCT03541980_exc_R2", "type": "Has_value", "arg1_id": "NCT03541980_exc_T6", "arg2_id": "NCT03541980_exc_T5", "normalized": [] }, { "id": "NCT03541980_exc_R3", "type": "Has_value", "arg1_id": "NCT03541980_exc_T8", "arg2_id": "NCT03541980_exc_T7", "normalized": [] }, { "id": "NCT03541980_exc_R4", "type": "Subsumes", "arg1_id": "NCT03541980_exc_T15", "arg2_id": "NCT03541980_exc_T14", "normalized": [] }, { "id": "NCT03541980_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03541980_exc_T16", "arg2_id": "NCT03541980_exc_T17", "normalized": [] }, { "id": "NCT03541980_exc_R6", "type": "Has_value", "arg1_id": "NCT03541980_exc_T23", "arg2_id": "NCT03541980_exc_T24", "normalized": [] }, { "id": "NCT03541980_exc_R7", "type": "Has_mood", "arg1_id": "NCT03541980_exc_T22", "arg2_id": "NCT03541980_exc_T21", "normalized": [] }, { "id": "NCT03541980_exc_R8", "type": "Has_negation", "arg1_id": "NCT03541980_exc_T21", "arg2_id": "NCT03541980_exc_T20", "normalized": [] }, { "id": "NCT03541980_exc_R9", "type": "Subsumes", "arg1_id": "NCT03541980_exc_T25", "arg2_id": "NCT03541980_exc_T26", "normalized": [] }, { "id": "NCT03541980_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03541980_exc_T27", "arg2_id": "NCT03541980_exc_T28", "normalized": [] } ]

[ { "id": "NCT03541980_inc_text", "type": "inclusion", "text": [ "Any patient age 4-16 years with sickle cell disease who presents the Pediatric ER with acute sickle cell pain crisis with a pain of 6/10 or higher\n" ], "offsets": [ [ 0, 147 ] ] } ]

[ { "id": "NCT03541980_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 12, 15 ] ], "normalized": [] }, { "id": "NCT03541980_inc_T2", "type": "Value", "text": [ "4-16 years" ], "offsets": [ [ 16, 26 ] ], "normalized": [] }, { "id": "NCT03541980_inc_T3", "type": "Condition", "text": [ "sickle cell disease" ], "offsets": [ [ 32, 51 ] ], "normalized": [] }, { "id": "NCT03541980_inc_T4", "type": "Visit", "text": [ "Pediatric ER" ], "offsets": [ [ 69, 81 ] ], "normalized": [] }, { "id": "NCT03541980_inc_T5", "type": "Condition", "text": [ "acute sickle cell pain crisis" ], "offsets": [ [ 87, 116 ] ], "normalized": [] }, { "id": "NCT03541980_inc_T6", "type": "Measurement", "text": [ "pain" ], "offsets": [ [ 124, 128 ] ], "normalized": [] }, { "id": "NCT03541980_inc_T7", "type": "Value", "text": [ "6/10 or higher" ], "offsets": [ [ 132, 146 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03541980_inc_R1", "type": "Has_value", "arg1_id": "NCT03541980_inc_T6", "arg2_id": "NCT03541980_inc_T7", "normalized": [] }, { "id": "NCT03541980_inc_R2", "type": "Has_value", "arg1_id": "NCT03541980_inc_T1", "arg2_id": "NCT03541980_inc_T2", "normalized": [] } ]

[ { "id": "NCT03555526_exc_text", "type": "exclusion", "text": [ "aged less than 20 years\nhistory of gastric resection surgery\nhistory of allergy to study drugs\npregnancy or lactating women\nsevere underlying illness, such as end stage renal disease, decompensated liver cirrhosis, or non-curative malignancy\n" ], "offsets": [ [ 0, 242 ] ] } ]

[ { "id": "NCT03555526_exc_T1", "type": "Person", "text": [ "aged" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T2", "type": "Value", "text": [ "less than 20 years" ], "offsets": [ [ 5, 23 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T3", "type": "Procedure", "text": [ "gastric resection surgery" ], "offsets": [ [ 35, 60 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T4", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 72, 79 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T5", "type": "Drug", "text": [ "study drugs" ], "offsets": [ [ 83, 94 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T6", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 95, 104 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T7", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 108, 117 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T8", "type": "Person", "text": [ "women" ], "offsets": [ [ 118, 123 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T9", "type": "Condition", "text": [ "severe underlying illness" ], "offsets": [ [ 124, 149 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T10", "type": "Condition", "text": [ "end stage renal disease" ], "offsets": [ [ 159, 182 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T11", "type": "Condition", "text": [ "liver cirrhosis" ], "offsets": [ [ 198, 213 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T12", "type": "Qualifier", "text": [ "decompensated" ], "offsets": [ [ 184, 197 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T13", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 231, 241 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T14", "type": "Qualifier", "text": [ "non-curative" ], "offsets": [ [ 218, 230 ] ], "normalized": [] }, { "id": "NCT03555526_exc_T15", "type": "Scope", "text": [ "end stage renal disease, decompensated liver cirrhosis, or non-curative malignancy" ], "offsets": [ [ 159, 241 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03555526_exc_R1", "type": "Has_value", "arg1_id": "NCT03555526_exc_T1", "arg2_id": "NCT03555526_exc_T2", "normalized": [] }, { "id": "NCT03555526_exc_R2", "type": "AND", "arg1_id": "NCT03555526_exc_T4", "arg2_id": "NCT03555526_exc_T5", "normalized": [] }, { "id": "NCT03555526_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03555526_exc_T11", "arg2_id": "NCT03555526_exc_T12", "normalized": [] }, { "id": "NCT03555526_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03555526_exc_T13", "arg2_id": "NCT03555526_exc_T14", "normalized": [] }, { "id": "NCT03555526_exc_R5", "type": "Subsumes", "arg1_id": "NCT03555526_exc_T9", "arg2_id": "NCT03555526_exc_T15", "normalized": [] } ]

[ { "id": "NCT03555526_inc_text", "type": "inclusion", "text": [ "H pylori infection failed after at least two eradication therapies\naged 20 years or greater\nwillingness to receive rescue therapy\n" ], "offsets": [ [ 0, 130 ] ] } ]

[ { "id": "NCT03555526_inc_T1", "type": "Condition", "text": [ "H pylori infection" ], "offsets": [ [ 0, 18 ] ], "normalized": [] }, { "id": "NCT03555526_inc_T2", "type": "Procedure", "text": [ "eradication therapies" ], "offsets": [ [ 45, 66 ] ], "normalized": [] }, { "id": "NCT03555526_inc_T3", "type": "Multiplier", "text": [ "at least two" ], "offsets": [ [ 32, 44 ] ], "normalized": [] }, { "id": "NCT03555526_inc_T4", "type": "Qualifier", "text": [ "failed" ], "offsets": [ [ 19, 25 ] ], "normalized": [] }, { "id": "NCT03555526_inc_T5", "type": "Person", "text": [ "aged" ], "offsets": [ [ 67, 71 ] ], "normalized": [] }, { "id": "NCT03555526_inc_T6", "type": "Value", "text": [ "20 years or greater" ], "offsets": [ [ 72, 91 ] ], "normalized": [] }, { "id": "NCT03555526_inc_T7", "type": "Mood", "text": [ "willingness" ], "offsets": [ [ 92, 103 ] ], "normalized": [] }, { "id": "NCT03555526_inc_T8", "type": "Procedure", "text": [ "rescue therapy" ], "offsets": [ [ 115, 129 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03555526_inc_R1", "type": "Has_multiplier", "arg1_id": "NCT03555526_inc_T2", "arg2_id": "NCT03555526_inc_T3", "normalized": [] }, { "id": "NCT03555526_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03555526_inc_T2", "arg2_id": "NCT03555526_inc_T4", "normalized": [] }, { "id": "NCT03555526_inc_R3", "type": "AND", "arg1_id": "NCT03555526_inc_T1", "arg2_id": "NCT03555526_inc_T2", "normalized": [] }, { "id": "NCT03555526_inc_R4", "type": "Has_value", "arg1_id": "NCT03555526_inc_T5", "arg2_id": "NCT03555526_inc_T6", "normalized": [] }, { "id": "NCT03555526_inc_R5", "type": "Has_mood", "arg1_id": "NCT03555526_inc_T8", "arg2_id": "NCT03555526_inc_T7", "normalized": [] } ]

[ { "id": "NCT03560310_exc_text", "type": "exclusion", "text": [ "Previously enrolled in this study (i.e. patient now at repeat encounter)\nConcomitant surgical procedure other than CABG\nAnticoagulant treatment after the operation (e.g. warfarin, direct thrombin inhibitors (dabigatran), FXa inhibitors (rivaroxaban, apixaban, heparin, low-molecular weight heparin, fondaparinux)\nDischarge from the operating hospital to an ICU at another hospital\nPregnancy or lactation\nKnown intolerance or contraindication to ticagrelor or ASA\nAny disorder that may interfere with drug absorption\nAny condition other than coronary artery disease with a life expectancy <12 months\nKnown chronic liver disease, renal disease requiring dialysis or bleeding disorder\nAtrioventricular block II and III in patients without pacemaker\nAny other indication for dual antiplatelet therapy, i.e. recent stent implantation\nDebilitating stroke within 90 days before inclusion\nPrevious intracranial bleeding\nTreatment with immunosuppressants (e.g. cyclosporine and tacrolimus)\nTreatment with strong CYP3A4-inhibitors (e.g. ketoconazole, clarithromycin, nefazodone, ritonavir or atazanavir)\nAny condition that in the opinion of the investigator may interfere with adherence to trial protocol\n" ], "offsets": [ [ 0, 1195 ] ] } ]

[ { "id": "NCT03560310_exc_T1", "type": "Observation", "text": [ "enrolled in this study" ], "offsets": [ [ 11, 33 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T2", "type": "Temporal", "text": [ "Previously" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T3", "type": "Procedure", "text": [ "surgical procedure" ], "offsets": [ [ 85, 103 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T4", "type": "Temporal", "text": [ "Concomitant" ], "offsets": [ [ 73, 84 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T5", "type": "Procedure", "text": [ "CABG" ], "offsets": [ [ 115, 119 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T6", "type": "Qualifier", "text": [ "other than" ], "offsets": [ [ 104, 114 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T7", "type": "Procedure", "text": [ "Anticoagulant treatment" ], "offsets": [ [ 120, 143 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T8", "type": "Temporal", "text": [ "after the operation" ], "offsets": [ [ 144, 163 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T9", "type": "Reference_point", "text": [ "the operation" ], "offsets": [ [ 150, 163 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T10", "type": "Procedure", "text": [ "operation" ], "offsets": [ [ 154, 163 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T11", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 170, 178 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T12", "type": "Drug", "text": [ "direct thrombin inhibitors" ], "offsets": [ [ 180, 206 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T13", "type": "Drug", "text": [ "dabigatran" ], "offsets": [ [ 208, 218 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T14", "type": "Drug", "text": [ "FXa inhibitors" ], "offsets": [ [ 221, 235 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T15", "type": "Drug", "text": [ "rivaroxaban" ], "offsets": [ [ 237, 248 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T16", "type": "Drug", "text": [ "apixaban" ], "offsets": [ [ 250, 258 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T17", "type": "Drug", "text": [ "heparin" ], "offsets": [ [ 260, 267 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T18", "type": "Drug", "text": [ "low-molecular weight heparin" ], "offsets": [ [ 269, 297 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T19", "type": "Drug", "text": [ "fondaparinux" ], "offsets": [ [ 299, 311 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T20", "type": "Scope", "text": [ "rivaroxaban, apixaban, heparin, low-molecular weight heparin, fondaparinux" ], "offsets": [ [ 237, 311 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T21", "type": "Scope", "text": [ "warfarin, direct thrombin inhibitors (dabigatran), FXa inhibitors (rivaroxaban, apixaban, heparin, low-molecular weight heparin, fondaparinux" ], "offsets": [ [ 170, 311 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T22", "type": "Observation", "text": [ "Discharge" ], "offsets": [ [ 313, 322 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T23", "type": "Visit", "text": [ "operating hospital" ], "offsets": [ [ 332, 350 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T24", "type": "Visit", "text": [ "ICU" ], "offsets": [ [ 357, 360 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T25", "type": "Qualifier", "text": [ "another" ], "offsets": [ [ 364, 371 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T26", "type": "Visit", "text": [ "hospital" ], "offsets": [ [ 372, 380 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T27", "type": "Scope", "text": [ "ICU at another hospital" ], "offsets": [ [ 357, 380 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T28", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 381, 390 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T29", "type": "Condition", "text": [ "lactation" ], "offsets": [ [ 394, 403 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T30", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 425, 441 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T31", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 410, 421 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T32", "type": "Drug", "text": [ "ticagrelor" ], "offsets": [ [ 445, 455 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T33", "type": "Drug", "text": [ "ASA" ], "offsets": [ [ 459, 462 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T34", "type": "Scope", "text": [ "intolerance or contraindication" ], "offsets": [ [ 410, 441 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T35", "type": "Scope", "text": [ "ticagrelor or ASA" ], "offsets": [ [ 445, 462 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T36", "type": "Condition", "text": [ "disorder" ], "offsets": [ [ 467, 475 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T37", "type": "Qualifier", "text": [ "may interfere with drug absorption" ], "offsets": [ [ 481, 515 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T38", "type": "Condition", "text": [ "coronary artery disease" ], "offsets": [ [ 541, 564 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T39", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 530, 540 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T40", "type": "Condition", "text": [ "condition" ], "offsets": [ [ 520, 529 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T41", "type": "Observation", "text": [ "life expectancy" ], "offsets": [ [ 572, 587 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T42", "type": "Value", "text": [ "<12 months" ], "offsets": [ [ 588, 598 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T43", "type": "Condition", "text": [ "chronic liver disease" ], "offsets": [ [ 605, 626 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T44", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 628, 641 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T45", "type": "Procedure", "text": [ "dialysis" ], "offsets": [ [ 652, 660 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T46", "type": "Condition", "text": [ "bleeding disorder" ], "offsets": [ [ 664, 681 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T47", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 642, 651 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T48", "type": "Condition", "text": [ "Atrioventricular block II" ], "offsets": [ [ 682, 707 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T49", "type": "Condition", "text": [ "ricular block II and I", "tie" ], "offsets": [ [ 691, 713 ], [ 721, 724 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T50", "type": "Negation", "text": [ "without" ], "offsets": [ [ 728, 735 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T51", "type": "Device", "text": [ "pacemaker" ], "offsets": [ [ 736, 745 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T52", "type": "Condition", "text": [ "dual antiplatelet therapy" ], "offsets": [ [ 771, 796 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T53", "type": "Procedure", "text": [ "stent implantation" ], "offsets": [ [ 810, 828 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T54", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 803, 809 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T55", "type": "Condition", "text": [ "indication" ], "offsets": [ [ 756, 766 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T56", "type": "Scope", "text": [ "indication for dual antiplatelet therapy" ], "offsets": [ [ 756, 796 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T57", "type": "Scope", "text": [ "recent stent implantation" ], "offsets": [ [ 803, 828 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T58", "type": "Temporal", "text": [ "within 90 days before inclusion" ], "offsets": [ [ 849, 880 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T59", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 842, 848 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T60", "type": "Condition", "text": [ "Debilitating" ], "offsets": [ [ 829, 841 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T61", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 881, 889 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T62", "type": "Procedure", "text": [ "intracranial bleeding" ], "offsets": [ [ 890, 911 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T63", "type": "Drug", "text": [ "immunosuppressants" ], "offsets": [ [ 927, 945 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T64", "type": "Drug", "text": [ "cyclosporine" ], "offsets": [ [ 952, 964 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T65", "type": "Drug", "text": [ "tacrolimus" ], "offsets": [ [ 969, 979 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T66", "type": "Scope", "text": [ "cyclosporine and tacrolimus" ], "offsets": [ [ 952, 979 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T67", "type": "Drug", "text": [ "strong CYP3A4-inhibitors" ], "offsets": [ [ 996, 1020 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T68", "type": "Drug", "text": [ "ketoconazole" ], "offsets": [ [ 1027, 1039 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T69", "type": "Drug", "text": [ "clarithromycin" ], "offsets": [ [ 1041, 1055 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T70", "type": "Drug", "text": [ "nefazodone" ], "offsets": [ [ 1057, 1067 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T71", "type": "Drug", "text": [ "ritonavir" ], "offsets": [ [ 1069, 1078 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T72", "type": "Drug", "text": [ "atazanavir" ], "offsets": [ [ 1082, 1092 ] ], "normalized": [] }, { "id": "NCT03560310_exc_T73", "type": "Scope", "text": [ "ketoconazole, clarithromycin, nefazodone, ritonavir or atazanavir" ], "offsets": [ [ 1027, 1092 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03560310_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03560310_exc_T1", "arg2_id": "NCT03560310_exc_T2", "normalized": [] }, { "id": "NCT03560310_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03560310_exc_T3", "arg2_id": "NCT03560310_exc_T4", "normalized": [] }, { "id": "NCT03560310_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03560310_exc_T5", "arg2_id": "NCT03560310_exc_T6", "normalized": [] }, { "id": "NCT03560310_exc_R4", "type": "AND", "arg1_id": "NCT03560310_exc_T3", "arg2_id": "NCT03560310_exc_T5", "normalized": [] }, { "id": "NCT03560310_exc_R6", "type": "Has_index", "arg1_id": "NCT03560310_exc_T8", "arg2_id": "NCT03560310_exc_T9", "normalized": [] }, { "id": "NCT03560310_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03560310_exc_T7", "arg2_id": "NCT03560310_exc_T8", "normalized": [] }, { "id": "NCT03560310_exc_R8", "type": "Subsumes", "arg1_id": "NCT03560310_exc_T12", "arg2_id": "NCT03560310_exc_T13", "normalized": [] }, { "id": "NCT03560310_exc_R9", "type": "Subsumes", "arg1_id": "NCT03560310_exc_T14", "arg2_id": "NCT03560310_exc_T20", "normalized": [] }, { "id": "NCT03560310_exc_R10", "type": "Subsumes", "arg1_id": "NCT03560310_exc_T7", "arg2_id": "NCT03560310_exc_T21", "normalized": [] }, { "id": "NCT03560310_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03560310_exc_T26", "arg2_id": "NCT03560310_exc_T25", "normalized": [] }, { "id": "NCT03560310_exc_R12", "type": "AND", "arg1_id": "NCT03560310_exc_T22", "arg2_id": "NCT03560310_exc_T23", "normalized": [] }, { "id": "NCT03560310_exc_R13", "type": "Has_scope", "arg1_id": "NCT03560310_exc_T22", "arg2_id": "NCT03560310_exc_T27", "normalized": [] }, { "id": "NCT03560310_exc_R14", "type": "Has_scope", "arg1_id": "NCT03560310_exc_T34", "arg2_id": "NCT03560310_exc_T35", "normalized": [] }, { "id": "NCT03560310_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT03560310_exc_T36", "arg2_id": "NCT03560310_exc_T37", "normalized": [] }, { "id": "NCT03560310_exc_R16", "type": "Has_negation", "arg1_id": "NCT03560310_exc_T38", "arg2_id": "NCT03560310_exc_T39", "normalized": [] }, { "id": "NCT03560310_exc_R17", "type": "AND", "arg1_id": "NCT03560310_exc_T40", "arg2_id": "NCT03560310_exc_T38", "normalized": [] }, { "id": "NCT03560310_exc_R18", "type": "Has_value", "arg1_id": "NCT03560310_exc_T41", "arg2_id": "NCT03560310_exc_T42", "normalized": [] }, { "id": "NCT03560310_exc_R20", "type": "Has_mood", "arg1_id": "NCT03560310_exc_T45", "arg2_id": "NCT03560310_exc_T47", "normalized": [] }, { "id": "NCT03560310_exc_R21", "type": "AND", "arg1_id": "NCT03560310_exc_T44", "arg2_id": "NCT03560310_exc_T45", "normalized": [] }, { "id": "NCT03560310_exc_R22", "type": "Has_negation", "arg1_id": "NCT03560310_exc_T51", "arg2_id": "NCT03560310_exc_T50", "normalized": [] }, { "id": "NCT03560310_exc_R23", "type": "Has_temporal", "arg1_id": "NCT03560310_exc_T53", "arg2_id": "NCT03560310_exc_T54", "normalized": [] }, { "id": "NCT03560310_exc_R24", "type": "AND", "arg1_id": "NCT03560310_exc_T55", "arg2_id": "NCT03560310_exc_T52", "normalized": [] }, { "id": "NCT03560310_exc_R25", "type": "Has_temporal", "arg1_id": "NCT03560310_exc_T59", "arg2_id": "NCT03560310_exc_T58", "normalized": [] }, { "id": "NCT03560310_exc_R26", "type": "AND", "arg1_id": "NCT03560310_exc_T59", "arg2_id": "NCT03560310_exc_T60", "normalized": [] }, { "id": "NCT03560310_exc_R27", "type": "Has_temporal", "arg1_id": "NCT03560310_exc_T62", "arg2_id": "NCT03560310_exc_T61", "normalized": [] }, { "id": "NCT03560310_exc_R28", "type": "Subsumes", "arg1_id": "NCT03560310_exc_T63", "arg2_id": "NCT03560310_exc_T66", "normalized": [] }, { "id": "NCT03560310_exc_R29", "type": "Subsumes", "arg1_id": "NCT03560310_exc_T67", "arg2_id": "NCT03560310_exc_T73", "normalized": [] } ]

[ { "id": "NCT03560310_inc_text", "type": "inclusion", "text": [ "Written informed consent\nAge =18 years\nHas undergone first time isolated CABG due to an episode of acute coronary syndrome (STEMI, NSTEMI, unstable angina) within 6 weeks before surgery\n" ], "offsets": [ [ 0, 186 ] ] } ]

[ { "id": "NCT03560310_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 25, 28 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T3", "type": "Value", "text": [ "=18 years" ], "offsets": [ [ 29, 38 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T4", "type": "Procedure", "text": [ "isolated CABG" ], "offsets": [ [ 64, 77 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T5", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 99, 122 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T6", "type": "Condition", "text": [ "STEMI" ], "offsets": [ [ 124, 129 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T7", "type": "Condition", "text": [ "NSTEMI" ], "offsets": [ [ 131, 137 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T8", "type": "Condition", "text": [ "unstable angina" ], "offsets": [ [ 139, 154 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T9", "type": "Temporal", "text": [ "within 6 weeks before surgery" ], "offsets": [ [ 156, 185 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T10", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 178, 185 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T11", "type": "Scope", "text": [ "STEMI, NSTEMI, unstable angina" ], "offsets": [ [ 124, 154 ] ], "normalized": [] }, { "id": "NCT03560310_inc_T12", "type": "Multiplier", "text": [ "first time" ], "offsets": [ [ 53, 63 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03560310_inc_R1", "type": "Has_value", "arg1_id": "NCT03560310_inc_T2", "arg2_id": "NCT03560310_inc_T3", "normalized": [] }, { "id": "NCT03560310_inc_R2", "type": "Has_index", "arg1_id": "NCT03560310_inc_T9", "arg2_id": "NCT03560310_inc_T10", "normalized": [] }, { "id": "NCT03560310_inc_R3", "type": "Subsumes", "arg1_id": "NCT03560310_inc_T5", "arg2_id": "NCT03560310_inc_T11", "normalized": [] }, { "id": "NCT03560310_inc_R4", "type": "AND", "arg1_id": "NCT03560310_inc_T4", "arg2_id": "NCT03560310_inc_T5", "normalized": [] }, { "id": "NCT03560310_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT03560310_inc_T4", "arg2_id": "NCT03560310_inc_T12", "normalized": [] } ]

[ { "id": "NCT03561753_exc_text", "type": "exclusion", "text": [ "Tuberculosis resistant to any of the study drugs (isoniazid, rifampin, EMB, PZA, CFZ, Pto)\nUnable to take oral medications.\nHistory of allergy or intolerance to any of the study drugs\nSerum aminotransferase (AST or ALT) 3x upper limit of normal or higher\nPregnant or nursing females, or plan to become pregnant or nurse during the study period\nMales planning to conceive a child during the study or within 6 months of cessation of treatment.\nAny treatment directed against active tuberculosis within 6 months preceding initiation of study drugs.\nSuspected or documented tuberculosis involving the central nervous system and/or bones and/or joints, and/or miliary tuberculosis and/or pericardial tuberculosis.\nHIV infected\nHBV infected or HCV infected (these increase the risk of TB-drug induced hepatotoxicity)\nWeight less than 40.0 kg.\nKnown allergy or intolerance to any of the study medications.\nIndividuals will be excluded from enrollment if, at the time of enrollment, their M. tuberculosis isolate is already known to be resistant to any of the study drugs.\nQTcF > 500 msec\nOther medical conditions, that, in the investigator's judgment, make study participation not in the individual's best interest.\nCurrent or planned incarceration or other involuntary detention\nHaving participated in other clinical studies with dosing of investigational agents within 8 weeks prior to trial start or currently enrolled in an investigational study that includes treatment with medicinal agents. Subjects who are participating in observational studies or who are in a follow up period of a trial that included drug therapy may be considered for inclusion.\n" ], "offsets": [ [ 0, 1650 ] ] } ]

[ { "id": "NCT03561753_exc_T1", "type": "Condition", "text": [ "Tuberculosis" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T2", "type": "Qualifier", "text": [ "resistant to" ], "offsets": [ [ 13, 25 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T3", "type": "Drug", "text": [ "study drugs" ], "offsets": [ [ 37, 48 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T4", "type": "Drug", "text": [ "isoniazid" ], "offsets": [ [ 50, 59 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T5", "type": "Drug", "text": [ "rifampin" ], "offsets": [ [ 61, 69 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T6", "type": "Drug", "text": [ "EMB" ], "offsets": [ [ 71, 74 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T7", "type": "Drug", "text": [ "PZA" ], "offsets": [ [ 76, 79 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T8", "type": "Drug", "text": [ "CFZ" ], "offsets": [ [ 81, 84 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T9", "type": "Drug", "text": [ "Pto" ], "offsets": [ [ 86, 89 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T10", "type": "Scope", "text": [ "isoniazid, rifampin, EMB, PZA, CFZ, Pto" ], "offsets": [ [ 50, 89 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T11", "type": "Observation", "text": [ "Unable to take oral medications" ], "offsets": [ [ 91, 122 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T12", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 135, 142 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T13", "type": "Observation", "text": [ "History" ], "offsets": [ [ 124, 131 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T14", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 146, 157 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T15", "type": "Drug", "text": [ "study drugs" ], "offsets": [ [ 172, 183 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T16", "type": "Scope", "text": [ "allergy or intolerance" ], "offsets": [ [ 135, 157 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T17", "type": "Measurement", "text": [ "Serum aminotransferase" ], "offsets": [ [ 184, 206 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T18", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 208, 211 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T19", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 215, 218 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T20", "type": "Scope", "text": [ "AST or ALT" ], "offsets": [ [ 208, 218 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T21", "type": "Scope", "text": [ "Serum aminotransferase (AST or ALT)" ], "offsets": [ [ 184, 219 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T22", "type": "Value", "text": [ "3x upper limit of normal or higher" ], "offsets": [ [ 220, 254 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T23", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 255, 263 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T24", "type": "Observation", "text": [ "nursing" ], "offsets": [ [ 267, 274 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T25", "type": "Person", "text": [ "females" ], "offsets": [ [ 275, 282 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T26", "type": "Mood", "text": [ "plan to" ], "offsets": [ [ 287, 294 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T27", "type": "Observation", "text": [ "become pregnant" ], "offsets": [ [ 295, 310 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T28", "type": "Observation", "text": [ "nurse" ], "offsets": [ [ 314, 319 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T29", "type": "Temporal", "text": [ "during the study period" ], "offsets": [ [ 320, 343 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T30", "type": "Scope", "text": [ "become pregnant or nurse" ], "offsets": [ [ 295, 319 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T31", "type": "Person", "text": [ "Males" ], "offsets": [ [ 344, 349 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T32", "type": "Mood", "text": [ "planning to" ], "offsets": [ [ 350, 361 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T33", "type": "Observation", "text": [ "conceive a child" ], "offsets": [ [ 362, 378 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T34", "type": "Temporal", "text": [ "during the study" ], "offsets": [ [ 379, 395 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T35", "type": "Temporal", "text": [ "within 6 months of cessation of treatment" ], "offsets": [ [ 399, 440 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T36", "type": "Reference_point", "text": [ "cessation of treatment" ], "offsets": [ [ 418, 440 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T37", "type": "Reference_point", "text": [ "the study" ], "offsets": [ [ 386, 395 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T38", "type": "Scope", "text": [ "during the study or within 6 months of cessation of treatment" ], "offsets": [ [ 379, 440 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T39", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 473, 479 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T40", "type": "Condition", "text": [ "tuberculosis" ], "offsets": [ [ 480, 492 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T41", "type": "Temporal", "text": [ "within 6 months preceding initiation of study drugs" ], "offsets": [ [ 493, 544 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T42", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 446, 455 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T43", "type": "Condition", "text": [ "tuberculosis" ], "offsets": [ [ 570, 582 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T44", "type": "Qualifier", "text": [ "central nervous system" ], "offsets": [ [ 597, 619 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T45", "type": "Qualifier", "text": [ "bones" ], "offsets": [ [ 627, 632 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T46", "type": "Qualifier", "text": [ "joints" ], "offsets": [ [ 640, 646 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T47", "type": "Qualifier", "text": [ "miliary tuberculosis" ], "offsets": [ [ 655, 675 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T48", "type": "Qualifier", "text": [ "pericardial tuberculosis" ], "offsets": [ [ 683, 707 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T49", "type": "Scope", "text": [ "central nervous system and/or bones and/or joints, and/or miliary tuberculosis and/or pericardial tuberculosis" ], "offsets": [ [ 597, 707 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T50", "type": "Mood", "text": [ "documented" ], "offsets": [ [ 559, 569 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T51", "type": "Mood", "text": [ "Suspected" ], "offsets": [ [ 546, 555 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T52", "type": "Scope", "text": [ "Suspected or documented" ], "offsets": [ [ 546, 569 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T53", "type": "Condition", "text": [ "HIV infected" ], "offsets": [ [ 709, 721 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T54", "type": "Condition", "text": [ "HBV infected" ], "offsets": [ [ 722, 734 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T55", "type": "Condition", "text": [ "HCV infected" ], "offsets": [ [ 738, 750 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T57", "type": "Measurement", "text": [ "Weight" ], "offsets": [ [ 811, 817 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T58", "type": "Value", "text": [ "less than 40.0 kg" ], "offsets": [ [ 818, 835 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T59", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 843, 850 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T60", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 854, 865 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T61", "type": "Drug", "text": [ "study medications" ], "offsets": [ [ 880, 897 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T62", "type": "Scope", "text": [ "allergy or intolerance" ], "offsets": [ [ 843, 865 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T63", "type": "Condition", "text": [ "M. tuberculosis isolate" ], "offsets": [ [ 981, 1004 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T64", "type": "Qualifier", "text": [ "resistant to any of the study drugs" ], "offsets": [ [ 1028, 1063 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T65", "type": "Drug", "text": [ "study drugs" ], "offsets": [ [ 1052, 1063 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T66", "type": "Measurement", "text": [ "QTcF" ], "offsets": [ [ 1065, 1069 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T67", "type": "Value", "text": [ "> 500 msec" ], "offsets": [ [ 1070, 1080 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T69", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 1209, 1216 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T70", "type": "Mood", "text": [ "planned" ], "offsets": [ [ 1220, 1227 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T71", "type": "Observation", "text": [ "incarceration" ], "offsets": [ [ 1228, 1241 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T72", "type": "Observation", "text": [ "involuntary detention" ], "offsets": [ [ 1251, 1272 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T73", "type": "Scope", "text": [ "incarceration or other involuntary detention" ], "offsets": [ [ 1228, 1272 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T74", "type": "Scope", "text": [ "Current or planned" ], "offsets": [ [ 1209, 1227 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T75", "type": "Observation", "text": [ "participated in other clinical studies" ], "offsets": [ [ 1280, 1318 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T76", "type": "Drug", "text": [ "investigational agents" ], "offsets": [ [ 1334, 1356 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T77", "type": "Temporal", "text": [ "within 8 weeks prior to trial start" ], "offsets": [ [ 1357, 1392 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T78", "type": "Temporal", "text": [ "currently" ], "offsets": [ [ 1396, 1405 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T79", "type": "Observation", "text": [ "enrolled in an investigational study" ], "offsets": [ [ 1406, 1442 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T80", "type": "Reference_point", "text": [ "trial start" ], "offsets": [ [ 1381, 1392 ] ], "normalized": [] }, { "id": "NCT03561753_exc_T81", "type": "Drug", "text": [ "medicinal agents" ], "offsets": [ [ 1472, 1488 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03561753_exc_R1", "type": "Subsumes", "arg1_id": "NCT03561753_exc_T3", "arg2_id": "NCT03561753_exc_T10", "normalized": [] }, { "id": "NCT03561753_exc_R2", "type": "AND", "arg1_id": "NCT03561753_exc_T2", "arg2_id": "NCT03561753_exc_T3", "normalized": [] }, { "id": "NCT03561753_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03561753_exc_T1", "arg2_id": "NCT03561753_exc_T2", "normalized": [] }, { "id": "NCT03561753_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03561753_exc_T16", "arg2_id": "NCT03561753_exc_T13", "normalized": [] }, { "id": "NCT03561753_exc_R5", "type": "AND", "arg1_id": "NCT03561753_exc_T16", "arg2_id": "NCT03561753_exc_T15", "normalized": [] }, { "id": "NCT03561753_exc_R6", "type": "Subsumes", "arg1_id": "NCT03561753_exc_T17", "arg2_id": "NCT03561753_exc_T20", "normalized": [] }, { "id": "NCT03561753_exc_R7", "type": "Has_value", "arg1_id": "NCT03561753_exc_T21", "arg2_id": "NCT03561753_exc_T22", "normalized": [] }, { "id": "NCT03561753_exc_R8", "type": "Has_mood", "arg1_id": "NCT03561753_exc_T30", "arg2_id": "NCT03561753_exc_T26", "normalized": [] }, { "id": "NCT03561753_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03561753_exc_T30", "arg2_id": "NCT03561753_exc_T29", "normalized": [] }, { "id": "NCT03561753_exc_R10", "type": "Has_mood", "arg1_id": "NCT03561753_exc_T33", "arg2_id": "NCT03561753_exc_T32", "normalized": [] }, { "id": "NCT03561753_exc_R11", "type": "Has_index", "arg1_id": "NCT03561753_exc_T35", "arg2_id": "NCT03561753_exc_T36", "normalized": [] }, { "id": "NCT03561753_exc_R12", "type": "Has_index", "arg1_id": "NCT03561753_exc_T34", "arg2_id": "NCT03561753_exc_T37", "normalized": [] }, { "id": "NCT03561753_exc_R13", "type": "Has_scope", "arg1_id": "NCT03561753_exc_T33", "arg2_id": "NCT03561753_exc_T38", "normalized": [] }, { "id": "NCT03561753_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT03561753_exc_T40", "arg2_id": "NCT03561753_exc_T39", "normalized": [] }, { "id": "NCT03561753_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03561753_exc_T40", "arg2_id": "NCT03561753_exc_T41", "normalized": [] }, { "id": "NCT03561753_exc_R16", "type": "AND", "arg1_id": "NCT03561753_exc_T42", "arg2_id": "NCT03561753_exc_T40", "normalized": [] }, { "id": "NCT03561753_exc_R17", "type": "Has_scope", "arg1_id": "NCT03561753_exc_T43", "arg2_id": "NCT03561753_exc_T49", "normalized": [] }, { "id": "NCT03561753_exc_R18", "type": "Has_scope", "arg1_id": "NCT03561753_exc_T43", "arg2_id": "NCT03561753_exc_T52", "normalized": [] }, { "id": "NCT03561753_exc_R19", "type": "Has_value", "arg1_id": "NCT03561753_exc_T57", "arg2_id": "NCT03561753_exc_T58", "normalized": [] }, { "id": "NCT03561753_exc_R20", "type": "AND", "arg1_id": "NCT03561753_exc_T62", "arg2_id": "NCT03561753_exc_T61", "normalized": [] }, { "id": "NCT03561753_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT03561753_exc_T63", "arg2_id": "NCT03561753_exc_T64", "normalized": [] }, { "id": "NCT03561753_exc_R23", "type": "Has_value", "arg1_id": "NCT03561753_exc_T66", "arg2_id": "NCT03561753_exc_T67", "normalized": [] }, { "id": "NCT03561753_exc_R24", "type": "Has_scope", "arg1_id": "NCT03561753_exc_T73", "arg2_id": "NCT03561753_exc_T74", "normalized": [] }, { "id": "NCT03561753_exc_R25", "type": "Has_index", "arg1_id": "NCT03561753_exc_T77", "arg2_id": "NCT03561753_exc_T80", "normalized": [] }, { "id": "NCT03561753_exc_R26", "type": "Has_temporal", "arg1_id": "NCT03561753_exc_T79", "arg2_id": "NCT03561753_exc_T78", "normalized": [] }, { "id": "NCT03561753_exc_R27", "type": "Has_temporal", "arg1_id": "NCT03561753_exc_T75", "arg2_id": "NCT03561753_exc_T77", "normalized": [] }, { "id": "NCT03561753_exc_R28", "type": "AND", "arg1_id": "NCT03561753_exc_T75", "arg2_id": "NCT03561753_exc_T76", "normalized": [] }, { "id": "NCT03561753_exc_R29", "type": "AND", "arg1_id": "NCT03561753_exc_T79", "arg2_id": "NCT03561753_exc_T81", "normalized": [] } ]

[ { "id": "NCT03561753_inc_text", "type": "inclusion", "text": [ "Newly diagnosed and untreated sputum smear positive tuberculosis patient\nPulmonary lesion consistent with TB by radiological examination\nPositive sputum culture, identification of bacterial type confirmed Mycobacterium tuberculosis. MGIT drug sensitivity test (DST) results are sensitive of the first-line drugs (isoniazid, streptomycin, rifampicin and ethambutol).\nAge 18 years-65 years old\nMales or non-pregnant, non-nursing females\nSerum or plasma aminotransferases (AST, ALT) less than 3 times the upper limit of normal\nSerum or plasma total bilirubin less than or equal to 2.5 times the upper limit of normal\nSerum or plasma creatinine level less than or equal to 2 times the upper limit of normal\nSerum or plasma potassium level greater than or equal to 3.5 meq/L\nHemoglobin level of 7.0 g/dL or greater\nPlatelet count of 100,000/mm3 or greater\nFor women of childbearing potential, a negative pregnancy test is required during screening\nProvides written informed consent\nWillingness and ability to attend scheduled follow-up visits and undergo study assessments.\n" ], "offsets": [ [ 0, 1069 ] ] } ]

[ { "id": "NCT03561753_inc_T1", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 20, 29 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T2", "type": "Qualifier", "text": [ "Newly diagnosed" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T3", "type": "Measurement", "text": [ "sputum smear" ], "offsets": [ [ 30, 42 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T4", "type": "Value", "text": [ "positive" ], "offsets": [ [ 43, 51 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T5", "type": "Condition", "text": [ "tuberculosis" ], "offsets": [ [ 52, 64 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T6", "type": "Scope", "text": [ "Newly diagnosed and untreated" ], "offsets": [ [ 0, 29 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T7", "type": "Condition", "text": [ "Pulmonary lesion" ], "offsets": [ [ 73, 89 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T8", "type": "Condition", "text": [ "TB" ], "offsets": [ [ 106, 108 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T9", "type": "Procedure", "text": [ "radiological examination" ], "offsets": [ [ 112, 136 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T10", "type": "Qualifier", "text": [ "consistent with TB" ], "offsets": [ [ 90, 108 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T11", "type": "Value", "text": [ "Positive" ], "offsets": [ [ 137, 145 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T12", "type": "Measurement", "text": [ "sputum culture" ], "offsets": [ [ 146, 160 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T13", "type": "Condition", "text": [ "Mycobacterium tuberculosis" ], "offsets": [ [ 205, 231 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T14", "type": "Qualifier", "text": [ "bacterial type" ], "offsets": [ [ 180, 194 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T15", "type": "Measurement", "text": [ "MGIT drug sensitivity test (DST)" ], "offsets": [ [ 233, 265 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T16", "type": "Value", "text": [ "sensitive of the first-line drugs (isoniazid, streptomycin, rifampicin and ethambutol)" ], "offsets": [ [ 278, 364 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T17", "type": "Drug", "text": [ "first-line drugs" ], "offsets": [ [ 295, 311 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T18", "type": "Drug", "text": [ "isoniazid" ], "offsets": [ [ 313, 322 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T19", "type": "Drug", "text": [ "streptomycin" ], "offsets": [ [ 324, 336 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T20", "type": "Drug", "text": [ "rifampicin" ], "offsets": [ [ 338, 348 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T21", "type": "Drug", "text": [ "ethambutol" ], "offsets": [ [ 353, 363 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T22", "type": "Scope", "text": [ "isoniazid, streptomycin, rifampicin and ethambutol" ], "offsets": [ [ 313, 363 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T23", "type": "Person", "text": [ "Age" ], "offsets": [ [ 366, 369 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T24", "type": "Value", "text": [ "18 years-65 years old" ], "offsets": [ [ 370, 391 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T25", "type": "Person", "text": [ "Males" ], "offsets": [ [ 392, 397 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T26", "type": "Negation", "text": [ "non-" ], "offsets": [ [ 401, 405 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T27", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 405, 413 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T28", "type": "Negation", "text": [ "non-" ], "offsets": [ [ 415, 419 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T29", "type": "Observation", "text": [ "nursing" ], "offsets": [ [ 419, 426 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T30", "type": "Person", "text": [ "females" ], "offsets": [ [ 427, 434 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T31", "type": "Scope", "text": [ "non-pregnant, non-nursing females" ], "offsets": [ [ 401, 434 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T32", "type": "Measurement", "text": [ "plasma aminotransferases" ], "offsets": [ [ 444, 468 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T33", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 470, 473 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T34", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 475, 478 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T35", "type": "Measurement", "text": [ " or ", "transferases (AST" ], "offsets": [ [ 440, 444 ], [ 456, 473 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T36", "type": "Scope", "text": [ "Serum or plasma aminotransferases" ], "offsets": [ [ 435, 468 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T37", "type": "Scope", "text": [ "AST, ALT" ], "offsets": [ [ 470, 478 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T38", "type": "Value", "text": [ "less than 3 times the upper limit of normal" ], "offsets": [ [ 480, 523 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T39", "type": "Qualifier", "text": [ "plasma" ], "offsets": [ [ 533, 539 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T40", "type": "Qualifier", "text": [ "Serum" ], "offsets": [ [ 524, 529 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T41", "type": "Measurement", "text": [ "total bilirubin" ], "offsets": [ [ 540, 555 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T42", "type": "Value", "text": [ "less than or equal to 2.5 times the upper limit of normal" ], "offsets": [ [ 556, 613 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T43", "type": "Scope", "text": [ "Serum or plasma" ], "offsets": [ [ 524, 539 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T44", "type": "Qualifier", "text": [ "plasma" ], "offsets": [ [ 623, 629 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T45", "type": "Qualifier", "text": [ "Serum" ], "offsets": [ [ 614, 619 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T46", "type": "Measurement", "text": [ "creatinine level" ], "offsets": [ [ 630, 646 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T47", "type": "Value", "text": [ "less than or equal to 2 times the upper limit of normal" ], "offsets": [ [ 647, 702 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T48", "type": "Scope", "text": [ "Serum or plasma" ], "offsets": [ [ 614, 629 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T49", "type": "Qualifier", "text": [ "Serum" ], "offsets": [ [ 703, 708 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T50", "type": "Qualifier", "text": [ "plasma" ], "offsets": [ [ 712, 718 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T51", "type": "Measurement", "text": [ "potassium level" ], "offsets": [ [ 719, 734 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T52", "type": "Value", "text": [ "greater than or equal to 3.5 meq/L" ], "offsets": [ [ 735, 769 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T53", "type": "Scope", "text": [ "Serum or plasma" ], "offsets": [ [ 703, 718 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T54", "type": "Measurement", "text": [ "Hemoglobin level" ], "offsets": [ [ 770, 786 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T55", "type": "Value", "text": [ "7.0 g/dL or greater" ], "offsets": [ [ 790, 809 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T56", "type": "Measurement", "text": [ "Platelet count" ], "offsets": [ [ 810, 824 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T57", "type": "Value", "text": [ "100,000/mm3 or greater" ], "offsets": [ [ 828, 850 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T58", "type": "Person", "text": [ "women" ], "offsets": [ [ 855, 860 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T59", "type": "Observation", "text": [ "childbearing potential" ], "offsets": [ [ 864, 886 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T60", "type": "Value", "text": [ "negative" ], "offsets": [ [ 890, 898 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T61", "type": "Measurement", "text": [ "pregnancy test" ], "offsets": [ [ 899, 913 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T62", "type": "Scope", "text": [ "women of childbearing potential" ], "offsets": [ [ 855, 886 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T63", "type": "Temporal", "text": [ "during screening" ], "offsets": [ [ 926, 942 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T64", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 933, 942 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T65", "type": "Observation", "text": [ "written informed consent" ], "offsets": [ [ 952, 976 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T66", "type": "Observation", "text": [ "ability to attend scheduled follow-up visits" ], "offsets": [ [ 993, 1037 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T67", "type": "Observation", "text": [ "tend sched", " assessments" ], "offsets": [ [ 1006, 1016 ], [ 1055, 1067 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T68", "type": "Observation", "text": [ "eduled follow-up visits and undergo", "nd ability" ], "offsets": [ [ 1014, 1049 ], [ 990, 1000 ] ], "normalized": [] }, { "id": "NCT03561753_inc_T69", "type": "Observation", "text": [ "ed", " assessments", "nd ability" ], "offsets": [ [ 1014, 1016 ], [ 1055, 1067 ], [ 990, 1000 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03561753_inc_R1", "type": "Has_value", "arg1_id": "NCT03561753_inc_T3", "arg2_id": "NCT03561753_inc_T4", "normalized": [] }, { "id": "NCT03561753_inc_R2", "type": "AND", "arg1_id": "NCT03561753_inc_T5", "arg2_id": "NCT03561753_inc_T3", "normalized": [] }, { "id": "NCT03561753_inc_R3", "type": "Has_scope", "arg1_id": "NCT03561753_inc_T5", "arg2_id": "NCT03561753_inc_T6", "normalized": [] }, { "id": "NCT03561753_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03561753_inc_T7", "arg2_id": "NCT03561753_inc_T10", "normalized": [] }, { "id": "NCT03561753_inc_R6", "type": "AND", "arg1_id": "NCT03561753_inc_T9", "arg2_id": "NCT03561753_inc_T7", "normalized": [] }, { "id": "NCT03561753_inc_R7", "type": "Has_value", "arg1_id": "NCT03561753_inc_T12", "arg2_id": "NCT03561753_inc_T11", "normalized": [] }, { "id": "NCT03561753_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03561753_inc_T13", "arg2_id": "NCT03561753_inc_T14", "normalized": [] }, { "id": "NCT03561753_inc_R9", "type": "Subsumes", "arg1_id": "NCT03561753_inc_T17", "arg2_id": "NCT03561753_inc_T22", "normalized": [] }, { "id": "NCT03561753_inc_R10", "type": "AND", "arg1_id": "NCT03561753_inc_T15", "arg2_id": "NCT03561753_inc_T17", "normalized": [] }, { "id": "NCT03561753_inc_R11", "type": "Has_value", "arg1_id": "NCT03561753_inc_T23", "arg2_id": "NCT03561753_inc_T24", "normalized": [] }, { "id": "NCT03561753_inc_R12", "type": "Has_negation", "arg1_id": "NCT03561753_inc_T27", "arg2_id": "NCT03561753_inc_T26", "normalized": [] }, { "id": "NCT03561753_inc_R13", "type": "Has_negation", "arg1_id": "NCT03561753_inc_T29", "arg2_id": "NCT03561753_inc_T28", "normalized": [] }, { "id": "NCT03561753_inc_R14", "type": "Subsumes", "arg1_id": "NCT03561753_inc_T36", "arg2_id": "NCT03561753_inc_T37", "normalized": [] }, { "id": "NCT03561753_inc_R15", "type": "Has_value", "arg1_id": "NCT03561753_inc_T36", "arg2_id": "NCT03561753_inc_T38", "normalized": [] }, { "id": "NCT03561753_inc_R16", "type": "Has_scope", "arg1_id": "NCT03561753_inc_T41", "arg2_id": "NCT03561753_inc_T43", "normalized": [] }, { "id": "NCT03561753_inc_R17", "type": "Has_value", "arg1_id": "NCT03561753_inc_T41", "arg2_id": "NCT03561753_inc_T42", "normalized": [] }, { "id": "NCT03561753_inc_R18", "type": "Has_scope", "arg1_id": "NCT03561753_inc_T46", "arg2_id": "NCT03561753_inc_T48", "normalized": [] }, { "id": "NCT03561753_inc_R19", "type": "Has_value", "arg1_id": "NCT03561753_inc_T46", "arg2_id": "NCT03561753_inc_T47", "normalized": [] }, { "id": "NCT03561753_inc_R20", "type": "Has_scope", "arg1_id": "NCT03561753_inc_T51", "arg2_id": "NCT03561753_inc_T53", "normalized": [] }, { "id": "NCT03561753_inc_R21", "type": "Has_value", "arg1_id": "NCT03561753_inc_T51", "arg2_id": "NCT03561753_inc_T52", "normalized": [] }, { "id": "NCT03561753_inc_R22", "type": "Has_value", "arg1_id": "NCT03561753_inc_T54", "arg2_id": "NCT03561753_inc_T55", "normalized": [] }, { "id": "NCT03561753_inc_R23", "type": "Has_value", "arg1_id": "NCT03561753_inc_T56", "arg2_id": "NCT03561753_inc_T57", "normalized": [] }, { "id": "NCT03561753_inc_R24", "type": "Has_value", "arg1_id": "NCT03561753_inc_T61", "arg2_id": "NCT03561753_inc_T60", "normalized": [] }, { "id": "NCT03561753_inc_R25", "type": "Has_index", "arg1_id": "NCT03561753_inc_T63", "arg2_id": "NCT03561753_inc_T64", "normalized": [] }, { "id": "NCT03561753_inc_R26", "type": "Has_temporal", "arg1_id": "NCT03561753_inc_T61", "arg2_id": "NCT03561753_inc_T63", "normalized": [] }, { "id": "NCT03561753_inc_R27", "type": "AND", "arg1_id": "NCT03561753_inc_T62", "arg2_id": "NCT03561753_inc_T61", "normalized": [] } ]

[ { "id": "NCT03589105_exc_text", "type": "exclusion", "text": [ "Diagnosis of primary progressive MS\nInability to complete an MRI (contraindications for MRI include but are not restricted to weight =140 kg, pacemaker, cochlear implants, presence of foreign substances in the eye, intracranial vascular clips, surgery within 6 weeks of entry into the study, coronary stent implanted within 8 weeks prior to the time of the intended MRI, etc…)\nGadolinium intolerance\nHistory of ischemic cerebrovascular disorders (e.g., stroke, transient ischemic attack) or ischemia of the spinal cord\nHistory or known presence of central nervous system (CNS) or spinal cord tumor (e.g., meningioma, glioma)\nHistory or known presence of potential metabolic causes of myelopathy (e.g., untreated vitamin B12 deficiency)\nHistory or known presence of infectious causes of myelopathy (e.g., syphilis, Lyme disease, human T-lymphotropic virus 1 (HTLV-1), herpes zoster myelopathy)\nHistory of genetically inherited progressive CNS degenerative disorder (e.g., hereditary paraparesis; MELAS [mitochondrial myopathy, encephalopathy, lactic acidosis, stroke] syndrome)\nNeuromyelitis optica\nHistory or known presence of systemic autoimmune disorders potentially causing progressive neurologic disease (e.g., lupus, anti-phospholipid antibody syndrome, Sjogren's syndrome, Behçet's disease, sarcoidosis)\nHistory of severe, clinically significant brain or spinal cord trauma (e.g., cerebral contusion, spinal cord compression)\nVulnerable patients (Patient referred to in Articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code)\n" ], "offsets": [ [ 0, 1558 ] ] } ]

[ { "id": "NCT03589105_exc_T1", "type": "Condition", "text": [ "progressive MS" ], "offsets": [ [ 21, 35 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T2", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 13, 20 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T3", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 61, 64 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T4", "type": "Mood", "text": [ "Inability to complete" ], "offsets": [ [ 36, 57 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T5", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 66, 83 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T6", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 88, 91 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T7", "type": "Measurement", "text": [ "weight" ], "offsets": [ [ 126, 132 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T8", "type": "Value", "text": [ "=140 kg" ], "offsets": [ [ 133, 140 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T9", "type": "Device", "text": [ "pacemaker" ], "offsets": [ [ 142, 151 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T10", "type": "Device", "text": [ "cochlear implants" ], "offsets": [ [ 153, 170 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T11", "type": "Device", "text": [ "foreign substances in the eye" ], "offsets": [ [ 184, 213 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T12", "type": "Device", "text": [ "intracranial vascular clips" ], "offsets": [ [ 215, 242 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T13", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 244, 251 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T14", "type": "Temporal", "text": [ "within 6 weeks of entry into the study" ], "offsets": [ [ 252, 290 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T15", "type": "Reference_point", "text": [ "entry into the study" ], "offsets": [ [ 270, 290 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T16", "type": "Device", "text": [ "coronary stent" ], "offsets": [ [ 292, 306 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T17", "type": "Procedure", "text": [ "implanted" ], "offsets": [ [ 307, 316 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T18", "type": "Temporal", "text": [ "within 8 weeks prior to the time of the intended MRI" ], "offsets": [ [ 317, 369 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T19", "type": "Reference_point", "text": [ "the time of the intended MRI" ], "offsets": [ [ 341, 369 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T20", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 366, 369 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T21", "type": "Mood", "text": [ "intended" ], "offsets": [ [ 357, 365 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T22", "type": "Scope", "text": [ "weight =140 kg, pacemaker, cochlear implants, presence of foreign substances in the eye, intracranial vascular clips, surgery within 6 weeks of entry into the study, coronary stent implanted within 8 weeks prior to the time of the intended MRI" ], "offsets": [ [ 126, 369 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T23", "type": "Scope", "text": [ "contraindications for MRI" ], "offsets": [ [ 66, 91 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T24", "type": "Scope", "text": [ "contraindications for MRI include but are not restricted to weight =140 kg, pacemaker, cochlear implants, presence of foreign substances in the eye, intracranial vascular clips, surgery within 6 weeks of entry into the study, coronary stent implanted within 8 weeks prior to the time of the intended MRI" ], "offsets": [ [ 66, 369 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T25", "type": "Scope", "text": [ "Inability to complete an MRI" ], "offsets": [ [ 36, 64 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T26", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 388, 399 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T27", "type": "Drug", "text": [ "Gadolinium" ], "offsets": [ [ 377, 387 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T28", "type": "Condition", "text": [ "ischemic cerebrovascular disorders" ], "offsets": [ [ 411, 445 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T29", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 453, 459 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T30", "type": "Condition", "text": [ "transient ischemic attack" ], "offsets": [ [ 461, 486 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T31", "type": "Condition", "text": [ "ischemia of the spinal cord" ], "offsets": [ [ 491, 518 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T32", "type": "Scope", "text": [ "stroke, transient ischemic attack" ], "offsets": [ [ 453, 486 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T33", "type": "Condition", "text": [ "ral nervous system (CNS) or", "r (e." ], "offsets": [ [ 552, 579 ], [ 596, 601 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T34", "type": "Condition", "text": [ "spinal cord tumor" ], "offsets": [ [ 580, 597 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T35", "type": "Condition", "text": [ "meningioma" ], "offsets": [ [ 605, 615 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T36", "type": "Condition", "text": [ "glioma" ], "offsets": [ [ 617, 623 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T37", "type": "Scope", "text": [ "meningioma, glioma" ], "offsets": [ [ 605, 623 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T38", "type": "Scope", "text": [ "central nervous system (CNS) or spinal cord tumo" ], "offsets": [ [ 548, 596 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T39", "type": "Condition", "text": [ "myelopathy" ], "offsets": [ [ 684, 694 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T40", "type": "Condition", "text": [ "metabolic causes" ], "offsets": [ [ 664, 680 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T41", "type": "Condition", "text": [ "vitamin B12 deficiency" ], "offsets": [ [ 712, 734 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T42", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 702, 711 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T43", "type": "Scope", "text": [ "metabolic causes of myelopathy" ], "offsets": [ [ 664, 694 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T44", "type": "Scope", "text": [ "untreated vitamin B12 deficiency" ], "offsets": [ [ 702, 734 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T45", "type": "Condition", "text": [ "infectious causes" ], "offsets": [ [ 765, 782 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T46", "type": "Condition", "text": [ "myelopathy" ], "offsets": [ [ 786, 796 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T47", "type": "Condition", "text": [ "syphilis" ], "offsets": [ [ 804, 812 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T48", "type": "Condition", "text": [ "Lyme disease" ], "offsets": [ [ 814, 826 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T49", "type": "Condition", "text": [ "human T-lymphotropic virus 1 (HTLV-1)" ], "offsets": [ [ 828, 865 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T50", "type": "Condition", "text": [ "herpes zoster myelopathy" ], "offsets": [ [ 867, 891 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T51", "type": "Scope", "text": [ "syphilis, Lyme disease, human T-lymphotropic virus 1 (HTLV-1), herpes zoster myelopathy" ], "offsets": [ [ 804, 891 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T52", "type": "Scope", "text": [ "infectious causes of myelopathy" ], "offsets": [ [ 765, 796 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T53", "type": "Condition", "text": [ "progressive CNS degenerative disorder" ], "offsets": [ [ 926, 963 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T54", "type": "Qualifier", "text": [ "genetically inherited" ], "offsets": [ [ 904, 925 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T55", "type": "Condition", "text": [ "hereditary paraparesis" ], "offsets": [ [ 971, 993 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T56", "type": "Condition", "text": [ "mitochondrial myopathy" ], "offsets": [ [ 1002, 1024 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T57", "type": "Condition", "text": [ "encephalopathy" ], "offsets": [ [ 1026, 1040 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T58", "type": "Condition", "text": [ "lactic acidosis" ], "offsets": [ [ 1042, 1057 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T59", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 1059, 1065 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T60", "type": "Condition", "text": [ "mitoc", "e)\nNeuro" ], "offsets": [ [ 1002, 1007 ], [ 1074, 1082 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T61", "type": "Scope", "text": [ "mitochondrial myopathy, encephalopathy, lactic acidosis, stroke" ], "offsets": [ [ 1002, 1065 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T62", "type": "Scope", "text": [ "hereditary paraparesis; MELAS [mitochondrial myopathy, encephalopathy, lactic acidosis, stroke] syndrome" ], "offsets": [ [ 971, 1075 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T63", "type": "Scope", "text": [ "genetically inherited progressive CNS degenerative disorder" ], "offsets": [ [ 904, 963 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T64", "type": "Condition", "text": [ "Neuromyelitis optica" ], "offsets": [ [ 1077, 1097 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T65", "type": "Observation", "text": [ "History" ], "offsets": [ [ 1098, 1105 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T66", "type": "Condition", "text": [ "systemic autoimmune disorders" ], "offsets": [ [ 1127, 1156 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T67", "type": "Condition", "text": [ "progressive neurologic disease" ], "offsets": [ [ 1177, 1207 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T68", "type": "Mood", "text": [ "potentially causing" ], "offsets": [ [ 1157, 1176 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T69", "type": "Condition", "text": [ "lupus" ], "offsets": [ [ 1215, 1220 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T70", "type": "Condition", "text": [ "anti-phospholipid antibody syndrome" ], "offsets": [ [ 1222, 1257 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T71", "type": "Condition", "text": [ "Sjogren's syndrome" ], "offsets": [ [ 1259, 1277 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T72", "type": "Condition", "text": [ "Behçet's disease" ], "offsets": [ [ 1279, 1295 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T73", "type": "Condition", "text": [ "sarcoidosis" ], "offsets": [ [ 1297, 1308 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T74", "type": "Scope", "text": [ "lupus, anti-phospholipid antibody syndrome, Sjogren's syndrome, Behçet's disease, sarcoidosis" ], "offsets": [ [ 1215, 1308 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T75", "type": "Scope", "text": [ "systemic autoimmune disorders potentially causing progressive neurologic disease" ], "offsets": [ [ 1127, 1207 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T76", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1321, 1327 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T77", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 1329, 1351 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T78", "type": "Condition", "text": [ "spinal cord trauma" ], "offsets": [ [ 1361, 1379 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T79", "type": "Condition", "text": [ "pinal", "g., ce" ], "offsets": [ [ 1362, 1367 ], [ 1383, 1389 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T80", "type": "Scope", "text": [ "brain or spinal cord trauma" ], "offsets": [ [ 1352, 1379 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T81", "type": "Condition", "text": [ "cerebral contusion" ], "offsets": [ [ 1387, 1405 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T82", "type": "Condition", "text": [ "spinal cord compression" ], "offsets": [ [ 1407, 1430 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T83", "type": "Scope", "text": [ "cerebral contusion, spinal cord compression" ], "offsets": [ [ 1387, 1430 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T84", "type": "Scope", "text": [ "severe, clinically significant brain or spinal cord trauma" ], "offsets": [ [ 1321, 1379 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T85", "type": "Observation", "text": [ "Vulnerable patients" ], "offsets": [ [ 1432, 1451 ] ], "normalized": [] }, { "id": "NCT03589105_exc_T86", "type": "Qualifier", "text": [ "Articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code" ], "offsets": [ [ 1476, 1556 ] ], "normalized": [] } ]

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[ { "id": "NCT03589105_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03589105_exc_T1", "arg2_id": "NCT03589105_exc_T2", "normalized": [] }, { "id": "NCT03589105_exc_R2", "type": "Has_mood", "arg1_id": "NCT03589105_exc_T3", "arg2_id": "NCT03589105_exc_T4", "normalized": [] }, { "id": "NCT03589105_exc_R3", "type": "AND", "arg1_id": "NCT03589105_exc_T5", "arg2_id": "NCT03589105_exc_T6", "normalized": [] }, { "id": "NCT03589105_exc_R4", "type": "Has_value", "arg1_id": "NCT03589105_exc_T7", "arg2_id": "NCT03589105_exc_T8", "normalized": [] }, { "id": "NCT03589105_exc_R5", "type": "Has_index", "arg1_id": "NCT03589105_exc_T14", "arg2_id": "NCT03589105_exc_T15", "normalized": [] }, { "id": "NCT03589105_exc_R6", "type": "Has_mood", "arg1_id": "NCT03589105_exc_T20", "arg2_id": "NCT03589105_exc_T21", "normalized": [] }, { "id": "NCT03589105_exc_R8", "type": "Has_index", "arg1_id": "NCT03589105_exc_T18", "arg2_id": "NCT03589105_exc_T19", "normalized": [] }, { "id": "NCT03589105_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03589105_exc_T17", "arg2_id": "NCT03589105_exc_T18", "normalized": [] }, { "id": "NCT03589105_exc_R10", "type": "AND", "arg1_id": "NCT03589105_exc_T17", "arg2_id": "NCT03589105_exc_T16", "normalized": [] }, { "id": "NCT03589105_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03589105_exc_T13", "arg2_id": "NCT03589105_exc_T14", "normalized": [] }, { "id": "NCT03589105_exc_R12", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T23", "arg2_id": "NCT03589105_exc_T22", "normalized": [] }, { "id": "NCT03589105_exc_R13", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T25", "arg2_id": "NCT03589105_exc_T22", "normalized": [] }, { "id": "NCT03589105_exc_R14", "type": "AND", "arg1_id": "NCT03589105_exc_T26", "arg2_id": "NCT03589105_exc_T27", "normalized": [] }, { "id": "NCT03589105_exc_R15", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T28", "arg2_id": "NCT03589105_exc_T32", "normalized": [] }, { "id": "NCT03589105_exc_R16", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T38", "arg2_id": "NCT03589105_exc_T37", "normalized": [] }, { "id": "NCT03589105_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT03589105_exc_T41", "arg2_id": "NCT03589105_exc_T42", "normalized": [] }, { "id": "NCT03589105_exc_R17", "type": "AND", "arg1_id": "NCT03589105_exc_T40", "arg2_id": "NCT03589105_exc_T39", "normalized": [] }, { "id": "NCT03589105_exc_R19", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T43", "arg2_id": "NCT03589105_exc_T44", "normalized": [] }, { "id": "NCT03589105_exc_R20", "type": "AND", "arg1_id": "NCT03589105_exc_T45", "arg2_id": "NCT03589105_exc_T46", "normalized": [] }, { "id": "NCT03589105_exc_R21", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T52", "arg2_id": "NCT03589105_exc_T51", "normalized": [] }, { "id": "NCT03589105_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT03589105_exc_T53", "arg2_id": "NCT03589105_exc_T54", "normalized": [] }, { "id": "NCT03589105_exc_R23", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T60", "arg2_id": "NCT03589105_exc_T61", "normalized": [] }, { "id": "NCT03589105_exc_R24", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T63", "arg2_id": "NCT03589105_exc_T62", "normalized": [] }, { "id": "NCT03589105_exc_R25", "type": "Has_mood", "arg1_id": "NCT03589105_exc_T67", "arg2_id": "NCT03589105_exc_T68", "normalized": [] }, { "id": "NCT03589105_exc_R26", "type": "AND", "arg1_id": "NCT03589105_exc_T66", "arg2_id": "NCT03589105_exc_T67", "normalized": [] }, { "id": "NCT03589105_exc_R27", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T75", "arg2_id": "NCT03589105_exc_T74", "normalized": [] }, { "id": "NCT03589105_exc_R28", "type": "Has_temporal", "arg1_id": "NCT03589105_exc_T75", "arg2_id": "NCT03589105_exc_T65", "normalized": [] }, { "id": "NCT03589105_exc_R29", "type": "Has_qualifier", "arg1_id": "NCT03589105_exc_T80", "arg2_id": "NCT03589105_exc_T77", "normalized": [] }, { "id": "NCT03589105_exc_R30", "type": "Has_qualifier", "arg1_id": "NCT03589105_exc_T80", "arg2_id": "NCT03589105_exc_T76", "normalized": [] }, { "id": "NCT03589105_exc_R31", "type": "Subsumes", "arg1_id": "NCT03589105_exc_T84", "arg2_id": "NCT03589105_exc_T83", "normalized": [] }, { "id": "NCT03589105_exc_R32", "type": "Has_qualifier", "arg1_id": "NCT03589105_exc_T85", "arg2_id": "NCT03589105_exc_T86", "normalized": [] } ]

[ { "id": "NCT03589105_inc_text", "type": "inclusion", "text": [ "Age >/=18 years at screening\nPatients with relapsing forms of multiple sclerosis (RMS) with active disease defined by clinical or imaging features: (i) at least one clinical relapse over a 6-month period prior to screening; (ii) AND/OR at least one T1 gadolinium-enhancing lesion or new and/or enlarging T2 lesion as detected by brain Magnetic Resonance Imaging (MRI) performed over a 3 months period prior to screening with no change of Disease-Modifying Treatment(s) (DMT) compared to a previous MRI performed within 24 months before screening\nFor women of childbearing potential: agreement to use an acceptable birth control method during the treatment period and for at least 12 months after the last dose of ocrelizumab\nParticipants should be beneficiary of healthcare coverage under the social security system\n" ], "offsets": [ [ 0, 816 ] ] } ]

[ { "id": "NCT03589105_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T2", "type": "Value", "text": [ ">/=18 years" ], "offsets": [ [ 4, 15 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T3", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 16, 28 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T4", "type": "Qualifier", "text": [ "relapsing forms" ], "offsets": [ [ 43, 58 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T5", "type": "Condition", "text": [ "multiple sclerosis (RMS)" ], "offsets": [ [ 62, 86 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T6", "type": "Qualifier", "text": [ "active disease" ], "offsets": [ [ 92, 106 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T7", "type": "Observation", "text": [ "imaging features" ], "offsets": [ [ 130, 146 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T8", "type": "Observation", "text": [ "linical", "eatures:" ], "offsets": [ [ 119, 126 ], [ 139, 147 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T9", "type": "Scope", "text": [ "clinical or imaging features" ], "offsets": [ [ 118, 146 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T10", "type": "Multiplier", "text": [ "t least one", "ver a 6-month period" ], "offsets": [ [ 153, 164 ], [ 183, 203 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T11", "type": "Condition", "text": [ "clinical relapse" ], "offsets": [ [ 165, 181 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T12", "type": "Temporal", "text": [ "prior to screening" ], "offsets": [ [ 204, 222 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T13", "type": "Multiplier", "text": [ "t least one", "ver a 3 months period" ], "offsets": [ [ 237, 248 ], [ 379, 400 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T14", "type": "Temporal", "text": [ "prior to screening" ], "offsets": [ [ 401, 419 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T15", "type": "Condition", "text": [ "T1 gadolinium-enhancing lesion" ], "offsets": [ [ 249, 279 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T16", "type": "Condition", "text": [ "T2 lesion" ], "offsets": [ [ 304, 313 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T17", "type": "Procedure", "text": [ "brain Magnetic Resonance Imaging (MRI)" ], "offsets": [ [ 329, 367 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T18", "type": "Qualifier", "text": [ "enlarging" ], "offsets": [ [ 294, 303 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T19", "type": "Temporal", "text": [ "new" ], "offsets": [ [ 283, 286 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T20", "type": "Scope", "text": [ "new and/or enlarging" ], "offsets": [ [ 283, 303 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T21", "type": "Scope", "text": [ "T1 gadolinium-enhancing lesion or new and/or enlarging T2 lesion as detected by brain Magnetic Resonance Imaging (MRI)" ], "offsets": [ [ 249, 367 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T22", "type": "Scope", "text": [ "T1 gadolinium-enhancing lesion or new and/or enlarging T2 lesion" ], "offsets": [ [ 249, 313 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T23", "type": "Negation", "text": [ "no" ], "offsets": [ [ 425, 427 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T24", "type": "Multiplier", "text": [ "change of" ], "offsets": [ [ 428, 437 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T25", "type": "Procedure", "text": [ "Disease-Modifying Treatment(s) (DMT)" ], "offsets": [ [ 438, 474 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T27", "type": "Scope", "text": [ "at least one clinical relapse over a 6-month period prior to screening; (ii) AND/OR at least one T1 gadolinium-enhancing lesion or new and/or enlarging T2 lesion as detected by brain Magnetic Resonance Imaging (MRI) performed over a 3 months period prior to screening with no change of Disease-Modifying Treatment(s) (DMT) compared to a previous MRI performed within 24 months before screening" ], "offsets": [ [ 152, 545 ] ], "normalized": [] }, { "id": "NCT03589105_inc_T29", "type": "Observation", "text": [ "beneficiary of healthcare coverage" ], "offsets": [ [ 748, 782 ] ], "normalized": [] } ]

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[ { "id": "NCT03589105_inc_R1", "type": "Has_value", "arg1_id": "NCT03589105_inc_T1", "arg2_id": "NCT03589105_inc_T2", "normalized": [] }, { "id": "NCT03589105_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03589105_inc_T1", "arg2_id": "NCT03589105_inc_T3", "normalized": [] }, { "id": "NCT03589105_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03589105_inc_T5", "arg2_id": "NCT03589105_inc_T4", "normalized": [] }, { "id": "NCT03589105_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03589105_inc_T5", "arg2_id": "NCT03589105_inc_T6", "normalized": [] }, { "id": "NCT03589105_inc_R5", "type": "Has_scope", "arg1_id": "NCT03589105_inc_T5", "arg2_id": "NCT03589105_inc_T9", "normalized": [] }, { "id": "NCT03589105_inc_R7", "type": "Has_multiplier", "arg1_id": "NCT03589105_inc_T11", "arg2_id": "NCT03589105_inc_T10", "normalized": [] }, { "id": "NCT03589105_inc_R6", "type": "Has_temporal", "arg1_id": "NCT03589105_inc_T11", "arg2_id": "NCT03589105_inc_T12", "normalized": [] }, { "id": "NCT03589105_inc_R8", "type": "Has_scope", "arg1_id": "NCT03589105_inc_T16", "arg2_id": "NCT03589105_inc_T20", "normalized": [] }, { "id": "NCT03589105_inc_R9", "type": "Has_multiplier", "arg1_id": "NCT03589105_inc_T21", "arg2_id": "NCT03589105_inc_T13", "normalized": [] }, { "id": "NCT03589105_inc_R10", "type": "AND", "arg1_id": "NCT03589105_inc_T22", "arg2_id": "NCT03589105_inc_T17", "normalized": [] }, { "id": "NCT03589105_inc_R11", "type": "Has_temporal", "arg1_id": "NCT03589105_inc_T21", "arg2_id": "NCT03589105_inc_T14", "normalized": [] }, { "id": "NCT03589105_inc_R12", "type": "Has_multiplier", "arg1_id": "NCT03589105_inc_T25", "arg2_id": "NCT03589105_inc_T24", "normalized": [] }, { "id": "NCT03589105_inc_R13", "type": "Has_negation", "arg1_id": "NCT03589105_inc_T24", "arg2_id": "NCT03589105_inc_T23", "normalized": [] }, { "id": "NCT03589105_inc_R14", "type": "AND", "arg1_id": "NCT03589105_inc_T21", "arg2_id": "NCT03589105_inc_T25", "normalized": [] }, { "id": "NCT03589105_inc_R15", "type": "Has_scope", "arg1_id": "NCT03589105_inc_T5", "arg2_id": "NCT03589105_inc_T27", "normalized": [] } ]

[ { "id": "NCT03615508_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

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[ { "id": "NCT03615508_inc_text", "type": "inclusion", "text": [ "Horner's Syndrome\nHistory of taking an alpha blocker (tamsulosin/ terazosin/doxazosin/alfuzosin/silodosin) medication\n" ], "offsets": [ [ 0, 118 ] ] } ]

[ { "id": "NCT03615508_inc_T1", "type": "Condition", "text": [ "Horner's Syndrome" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03615508_inc_T2", "type": "Drug", "text": [ "alpha blocker" ], "offsets": [ [ 39, 52 ] ], "normalized": [] }, { "id": "NCT03615508_inc_T3", "type": "Drug", "text": [ "tamsulosin" ], "offsets": [ [ 54, 64 ] ], "normalized": [] }, { "id": "NCT03615508_inc_T4", "type": "Drug", "text": [ "terazosin" ], "offsets": [ [ 66, 75 ] ], "normalized": [] }, { "id": "NCT03615508_inc_T5", "type": "Drug", "text": [ "doxazosin" ], "offsets": [ [ 76, 85 ] ], "normalized": [] }, { "id": "NCT03615508_inc_T6", "type": "Drug", "text": [ "alfuzosin" ], "offsets": [ [ 86, 95 ] ], "normalized": [] }, { "id": "NCT03615508_inc_T7", "type": "Drug", "text": [ "silodosin" ], "offsets": [ [ 96, 105 ] ], "normalized": [] }, { "id": "NCT03615508_inc_T8", "type": "Scope", "text": [ "tamsulosin/ terazosin/doxazosin/alfuzosin/silodosin" ], "offsets": [ [ 54, 105 ] ], "normalized": [] } ]

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[ { "id": "NCT03615508_inc_R1", "type": "Subsumes", "arg1_id": "NCT03615508_inc_T2", "arg2_id": "NCT03615508_inc_T8", "normalized": [] } ]

[ { "id": "NCT03619707_exc_text", "type": "exclusion", "text": [ "Preexisting untreated medical condition (thyroid disease, diabetes mellitus, hypertension, pulmonary conditions, cardiac condition…)\nHistory of three or more consecutively failed In Vitro Fertilization (IVF) cycles after embryo transfer\nHistory of three or more miscarriages\nPrevious allergy reactions to progesterone products\n" ], "offsets": [ [ 0, 327 ] ] } ]

[ { "id": "NCT03619707_exc_T1", "type": "Condition", "text": [ "medical condition" ], "offsets": [ [ 22, 39 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T3", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 12, 21 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T2", "type": "Condition", "text": [ "thyroid disease" ], "offsets": [ [ 41, 56 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T4", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 58, 75 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T5", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 77, 89 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T6", "type": "Condition", "text": [ "pulmonary conditions" ], "offsets": [ [ 91, 111 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T7", "type": "Condition", "text": [ "cardiac condition" ], "offsets": [ [ 113, 130 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T8", "type": "Scope", "text": [ "thyroid disease, diabetes mellitus, hypertension, pulmonary conditions, cardiac condition" ], "offsets": [ [ 41, 130 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T9", "type": "Qualifier", "text": [ "Preexisting" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T10", "type": "Multiplier", "text": [ "three or more" ], "offsets": [ [ 144, 157 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T11", "type": "Procedure", "text": [ "In Vitro Fertilization" ], "offsets": [ [ 179, 201 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T12", "type": "Procedure", "text": [ "IVF" ], "offsets": [ [ 203, 206 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T13", "type": "Qualifier", "text": [ "consecutively failed" ], "offsets": [ [ 158, 178 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T14", "type": "Temporal", "text": [ "after embryo transfer" ], "offsets": [ [ 215, 236 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T15", "type": "Reference_point", "text": [ "embryo transfer" ], "offsets": [ [ 221, 236 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T16", "type": "Procedure", "text": [ "embryo transfer" ], "offsets": [ [ 221, 236 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T17", "type": "Multiplier", "text": [ "three or more" ], "offsets": [ [ 248, 261 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T18", "type": "Condition", "text": [ "miscarriages" ], "offsets": [ [ 262, 274 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T19", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 284, 291 ] ], "normalized": [] }, { "id": "NCT03619707_exc_T20", "type": "Drug", "text": [ "progesterone products" ], "offsets": [ [ 305, 326 ] ], "normalized": [] } ]

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[ { "id": "NCT03619707_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03619707_exc_T1", "arg2_id": "NCT03619707_exc_T3", "normalized": [] }, { "id": "NCT03619707_exc_R2", "type": "Has_scope", "arg1_id": "NCT03619707_exc_T1", "arg2_id": "NCT03619707_exc_T8", "normalized": [] }, { "id": "NCT03619707_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03619707_exc_T1", "arg2_id": "NCT03619707_exc_T9", "normalized": [] }, { "id": "NCT03619707_exc_R4", "type": "Subsumes", "arg1_id": "NCT03619707_exc_T11", "arg2_id": "NCT03619707_exc_T12", "normalized": [] }, { "id": "NCT03619707_exc_R5", "type": "AND", "arg1_id": "NCT03619707_exc_T15", "arg2_id": "NCT03619707_exc_T16", "normalized": [] }, { "id": "NCT03619707_exc_R6", "type": "Has_index", "arg1_id": "NCT03619707_exc_T14", "arg2_id": "NCT03619707_exc_T15", "normalized": [] }, { "id": "NCT03619707_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03619707_exc_T11", "arg2_id": "NCT03619707_exc_T13", "normalized": [] }, { "id": "NCT03619707_exc_R8", "type": "Has_multiplier", "arg1_id": "NCT03619707_exc_T11", "arg2_id": "NCT03619707_exc_T10", "normalized": [] }, { "id": "NCT03619707_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03619707_exc_T11", "arg2_id": "NCT03619707_exc_T14", "normalized": [] }, { "id": "NCT03619707_exc_R10", "type": "Has_multiplier", "arg1_id": "NCT03619707_exc_T18", "arg2_id": "NCT03619707_exc_T17", "normalized": [] }, { "id": "NCT03619707_exc_R11", "type": "AND", "arg1_id": "NCT03619707_exc_T19", "arg2_id": "NCT03619707_exc_T20", "normalized": [] } ]

[ { "id": "NCT03619707_inc_text", "type": "inclusion", "text": [ "Normal uterine cavity\nNormal Hormonal investigation: TSH,PRL,FBS\nFrozen embryo transfer cycles: at least 2 embryos\nPrimary or secondary infertility: tubal occlusion, male factor, unexplained, endometriosis, ovarian factors…\nBody mass index (BMI) =18 to =30 kg/m2\n" ], "offsets": [ [ 0, 263 ] ] } ]

[ { "id": "NCT03619707_inc_T1", "type": "Condition", "text": [ "uterine cavity" ], "offsets": [ [ 7, 21 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T2", "type": "Qualifier", "text": [ "Normal" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T3", "type": "Qualifier", "text": [ "Normal" ], "offsets": [ [ 22, 28 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T4", "type": "Measurement", "text": [ "Hormonal investigation" ], "offsets": [ [ 29, 51 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T5", "type": "Measurement", "text": [ "TSH" ], "offsets": [ [ 53, 56 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T6", "type": "Measurement", "text": [ "PRL" ], "offsets": [ [ 57, 60 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T7", "type": "Measurement", "text": [ "FBS" ], "offsets": [ [ 61, 64 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T8", "type": "Scope", "text": [ "TSH,PRL,FBS" ], "offsets": [ [ 53, 64 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T9", "type": "Procedure", "text": [ "Frozen embryo transfer cycles" ], "offsets": [ [ 65, 94 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T10", "type": "Multiplier", "text": [ "at least 2" ], "offsets": [ [ 96, 106 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T11", "type": "Condition", "text": [ "embryos" ], "offsets": [ [ 107, 114 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T12", "type": "Condition", "text": [ "mary or", "ertility: t" ], "offsets": [ [ 118, 125 ], [ 139, 150 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T13", "type": "Condition", "text": [ "ondary in", "ertility: t" ], "offsets": [ [ 129, 138 ], [ 139, 150 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T14", "type": "Condition", "text": [ "tubal occlusion" ], "offsets": [ [ 149, 164 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T15", "type": "Observation", "text": [ "male factor" ], "offsets": [ [ 166, 177 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T16", "type": "Observation", "text": [ "xplained, e", "tors…\nB" ], "offsets": [ [ 182, 193 ], [ 218, 225 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T17", "type": "Condition", "text": [ "endometriosis" ], "offsets": [ [ 192, 205 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T18", "type": "Observation", "text": [ "ovarian factors" ], "offsets": [ [ 207, 222 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T19", "type": "Scope", "text": [ "tubal occlusion, male factor, unexplained, endometriosis, ovarian factors" ], "offsets": [ [ 149, 222 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T20", "type": "Scope", "text": [ "Primary or secondary infertility" ], "offsets": [ [ 115, 147 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T21", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 224, 239 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T22", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 241, 244 ] ], "normalized": [] }, { "id": "NCT03619707_inc_T23", "type": "Value", "text": [ "=18 to =30 kg/m2" ], "offsets": [ [ 246, 262 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03619707_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03619707_inc_T4", "arg2_id": "NCT03619707_inc_T3", "normalized": [] }, { "id": "NCT03619707_inc_R2", "type": "Subsumes", "arg1_id": "NCT03619707_inc_T4", "arg2_id": "NCT03619707_inc_T8", "normalized": [] }, { "id": "NCT03619707_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT03619707_inc_T11", "arg2_id": "NCT03619707_inc_T10", "normalized": [] }, { "id": "NCT03619707_inc_R4", "type": "AND", "arg1_id": "NCT03619707_inc_T9", "arg2_id": "NCT03619707_inc_T11", "normalized": [] }, { "id": "NCT03619707_inc_R5", "type": "Subsumes", "arg1_id": "NCT03619707_inc_T20", "arg2_id": "NCT03619707_inc_T19", "normalized": [] }, { "id": "NCT03619707_inc_R6", "type": "Subsumes", "arg1_id": "NCT03619707_inc_T21", "arg2_id": "NCT03619707_inc_T22", "normalized": [] }, { "id": "NCT03619707_inc_R7", "type": "Has_value", "arg1_id": "NCT03619707_inc_T21", "arg2_id": "NCT03619707_inc_T23", "normalized": [] } ]

[ { "id": "NCT03620526_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03620526_inc_text", "type": "inclusion", "text": [ "presence of typical HF symptoms and signs\nLV ejection fraction = 50\nelevated levels of NT-proBNP (at least >125 pg/ml)\nechocardiographic structural (a left atrial volume index > 34 mL/m2 or a left ventricular mass index =115 g/m2 for males and =95 g/m2 for females) or functional alterations (E/e'=13 and a mean e' septal and lateral wall < 9 cm/s).\n" ], "offsets": [ [ 0, 350 ] ] } ]

[ { "id": "NCT03620526_inc_T1", "type": "Condition", "text": [ "HF symptoms" ], "offsets": [ [ 20, 31 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T2", "type": "Condition", "text": [ "HF", "signs" ], "offsets": [ [ 20, 22 ], [ 36, 41 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T3", "type": "Qualifier", "text": [ "typical" ], "offsets": [ [ 12, 19 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T4", "type": "Scope", "text": [ "HF symptoms and signs" ], "offsets": [ [ 20, 41 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T5", "type": "Measurement", "text": [ "LV ejection fraction" ], "offsets": [ [ 42, 62 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T6", "type": "Value", "text": [ "= 50" ], "offsets": [ [ 63, 67 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T7", "type": "Measurement", "text": [ "NT-proBNP" ], "offsets": [ [ 87, 96 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T8", "type": "Qualifier", "text": [ "elevated" ], "offsets": [ [ 68, 76 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T9", "type": "Value", "text": [ "at least >125 pg/ml" ], "offsets": [ [ 98, 117 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T10", "type": "Measurement", "text": [ "echocardiographic structural" ], "offsets": [ [ 119, 147 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T11", "type": "Measurement", "text": [ "left atrial volume inde" ], "offsets": [ [ 151, 174 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T12", "type": "Value", "text": [ "> 34 mL/m2" ], "offsets": [ [ 176, 186 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T13", "type": "Measurement", "text": [ "left ventricular mass index" ], "offsets": [ [ 192, 219 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T14", "type": "Value", "text": [ "=115 g/m2" ], "offsets": [ [ 220, 229 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T15", "type": "Person", "text": [ "males" ], "offsets": [ [ 234, 239 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T16", "type": "Person", "text": [ "females" ], "offsets": [ [ 257, 264 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T17", "type": "Measurement", "text": [ "left ventricular mass index" ], "offsets": [ [ 192, 219 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T18", "type": "Value", "text": [ "=95 g/m2" ], "offsets": [ [ 244, 252 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T19", "type": "Measurement", "text": [ "functional alterations" ], "offsets": [ [ 269, 291 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T20", "type": "Measurement", "text": [ "E/e'" ], "offsets": [ [ 293, 297 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T21", "type": "Value", "text": [ "=13" ], "offsets": [ [ 297, 300 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T22", "type": "Measurement", "text": [ "mean e' septal and lateral wall" ], "offsets": [ [ 307, 338 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T23", "type": "Value", "text": [ "< 9 cm/s" ], "offsets": [ [ 339, 347 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T24", "type": "Scope", "text": [ "E/e'=13 and a mean e' septal and lateral wall < 9 cm/s)" ], "offsets": [ [ 293, 348 ] ], "normalized": [] }, { "id": "NCT03620526_inc_T25", "type": "Scope", "text": [ "left atrial volume index > 34 mL/m2 or a left ventricular mass index =115 g/m2 for males and =95 g/m2 for females" ], "offsets": [ [ 151, 264 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03620526_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03620526_inc_T4", "arg2_id": "NCT03620526_inc_T3", "normalized": [] }, { "id": "NCT03620526_inc_R2", "type": "Has_value", "arg1_id": "NCT03620526_inc_T5", "arg2_id": "NCT03620526_inc_T6", "normalized": [] }, { "id": "NCT03620526_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03620526_inc_T7", "arg2_id": "NCT03620526_inc_T8", "normalized": [] }, { "id": "NCT03620526_inc_R4", "type": "Has_value", "arg1_id": "NCT03620526_inc_T7", "arg2_id": "NCT03620526_inc_T9", "normalized": [] }, { "id": "NCT03620526_inc_R5", "type": "Has_value", "arg1_id": "NCT03620526_inc_T17", "arg2_id": "NCT03620526_inc_T14", "normalized": [] }, { "id": "NCT03620526_inc_R6", "type": "AND", "arg1_id": "NCT03620526_inc_T17", "arg2_id": "NCT03620526_inc_T15", "normalized": [] }, { "id": "NCT03620526_inc_R7", "type": "Has_value", "arg1_id": "NCT03620526_inc_T13", "arg2_id": "NCT03620526_inc_T18", "normalized": [] }, { "id": "NCT03620526_inc_R8", "type": "AND", "arg1_id": "NCT03620526_inc_T13", "arg2_id": "NCT03620526_inc_T16", "normalized": [] }, { "id": "NCT03620526_inc_R9", "type": "Has_value", "arg1_id": "NCT03620526_inc_T20", "arg2_id": "NCT03620526_inc_T21", "normalized": [] }, { "id": "NCT03620526_inc_R10", "type": "Has_value", "arg1_id": "NCT03620526_inc_T22", "arg2_id": "NCT03620526_inc_T23", "normalized": [] }, { "id": "NCT03620526_inc_R11", "type": "Subsumes", "arg1_id": "NCT03620526_inc_T19", "arg2_id": "NCT03620526_inc_T24", "normalized": [] }, { "id": "NCT03620526_inc_R12", "type": "Has_value", "arg1_id": "NCT03620526_inc_T11", "arg2_id": "NCT03620526_inc_T12", "normalized": [] }, { "id": "NCT03620526_inc_R13", "type": "Subsumes", "arg1_id": "NCT03620526_inc_T10", "arg2_id": "NCT03620526_inc_T25", "normalized": [] } ]

[ { "id": "NCT03623789_exc_text", "type": "exclusion", "text": [ "Preoperative Hemoglobin <U+2266>11 g/dl\nHistory of infection or intraarticular fracture of the affective hip\nRenal function deficiency (GFR <30 ml/min/1.73m2)\nElevated liver enzyme (aspartate transaminase (AST)/ alanine transaminase(ALT) level are more than twice normal range) , history of liver cirrhosis, impaired liver function(elevated total bilirubin level) and coagulopathy (including long-term use anticoagulant)\nHistory of deep vein thrombosis, ischemic heart disease or stroke\nContraindications of tranexamic acid, floseal, or rivaroxaban\nAllergy to tranexamic acid, floseal, rivaroxaban, or the excipients\nHistory of heparin-induced thrombocytopenia (HIT)\nCoagulopathy or bleeding tendency caused by organ dysfunction, such as cirrhosis, bone marrow suppression etc.\nPatient who have active bleeding disorder, such as intracranial hemorrhage, upper gastrointestinal bleeding, hematuria.\nPatients with known allergies to materials of bovine origin.\n" ], "offsets": [ [ 0, 959 ] ] } ]

[ { "id": "NCT03623789_exc_T1", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T2", "type": "Measurement", "text": [ "Hemoglobin" ], "offsets": [ [ 13, 23 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T3", "type": "Value", "text": [ "<U+2266>11 g/dl" ], "offsets": [ [ 24, 39 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T4", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 51, 60 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T5", "type": "Condition", "text": [ "intraarticular fracture" ], "offsets": [ [ 64, 87 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T6", "type": "Qualifier", "text": [ "affective hip" ], "offsets": [ [ 95, 108 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T7", "type": "Scope", "text": [ "infection or intraarticular fracture" ], "offsets": [ [ 51, 87 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T8", "type": "Observation", "text": [ "History" ], "offsets": [ [ 40, 47 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T9", "type": "Condition", "text": [ "Renal function deficiency" ], "offsets": [ [ 109, 134 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T10", "type": "Measurement", "text": [ "GFR" ], "offsets": [ [ 136, 139 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T11", "type": "Value", "text": [ "<30 ml/min/1.73m2" ], "offsets": [ [ 140, 157 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T12", "type": "Scope", "text": [ "GFR <30 ml/min/1.73m2" ], "offsets": [ [ 136, 157 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T13", "type": "Measurement", "text": [ "liver enzyme" ], "offsets": [ [ 168, 180 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T14", "type": "Value", "text": [ "Elevated" ], "offsets": [ [ 159, 167 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T15", "type": "Measurement", "text": [ "aspartate transaminase (AST)/ alanine transaminase(ALT) level" ], "offsets": [ [ 182, 243 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T16", "type": "Value", "text": [ "more than twice normal range" ], "offsets": [ [ 248, 276 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T17", "type": "Observation", "text": [ "history" ], "offsets": [ [ 280, 287 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T18", "type": "Condition", "text": [ "liver cirrhosis" ], "offsets": [ [ 291, 306 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T19", "type": "Condition", "text": [ "impaired liver function" ], "offsets": [ [ 308, 331 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T20", "type": "Value", "text": [ "elevated" ], "offsets": [ [ 332, 340 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T21", "type": "Measurement", "text": [ "total bilirubin level" ], "offsets": [ [ 341, 362 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T22", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 368, 380 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T23", "type": "Multiplier", "text": [ "long-term use" ], "offsets": [ [ 392, 405 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T24", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 406, 419 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T25", "type": "Scope", "text": [ "long-term use anticoagulant" ], "offsets": [ [ 392, 419 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T26", "type": "Condition", "text": [ "deep vein thrombosis" ], "offsets": [ [ 432, 452 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T27", "type": "Condition", "text": [ "ischemic heart disease" ], "offsets": [ [ 454, 476 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T28", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 480, 486 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T29", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 487, 504 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T30", "type": "Drug", "text": [ "tranexamic acid" ], "offsets": [ [ 508, 523 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T31", "type": "Drug", "text": [ "floseal" ], "offsets": [ [ 525, 532 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T32", "type": "Drug", "text": [ "rivaroxaban" ], "offsets": [ [ 537, 548 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T33", "type": "Scope", "text": [ "tranexamic acid, floseal, or rivaroxaban" ], "offsets": [ [ 508, 548 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T34", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 549, 556 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T35", "type": "Drug", "text": [ "tranexamic acid" ], "offsets": [ [ 560, 575 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T36", "type": "Drug", "text": [ "floseal" ], "offsets": [ [ 577, 584 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T37", "type": "Drug", "text": [ "rivaroxaban" ], "offsets": [ [ 586, 597 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T38", "type": "Drug", "text": [ "excipients" ], "offsets": [ [ 606, 616 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T39", "type": "Scope", "text": [ "tranexamic acid, floseal, rivaroxaban, or the excipients" ], "offsets": [ [ 560, 616 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T40", "type": "Condition", "text": [ "heparin-induced thrombocytopenia (HIT)" ], "offsets": [ [ 628, 666 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T41", "type": "Observation", "text": [ "History" ], "offsets": [ [ 617, 624 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T42", "type": "Condition", "text": [ "Coagulopathy" ], "offsets": [ [ 667, 679 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T43", "type": "Condition", "text": [ "bleeding tendency" ], "offsets": [ [ 683, 700 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T44", "type": "Condition", "text": [ "organ dysfunction" ], "offsets": [ [ 711, 728 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T45", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 738, 747 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T46", "type": "Condition", "text": [ "bone marrow suppression" ], "offsets": [ [ 749, 772 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T47", "type": "Scope", "text": [ "cirrhosis, bone marrow suppression" ], "offsets": [ [ 738, 772 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T48", "type": "Scope", "text": [ "Coagulopathy or bleeding tendency" ], "offsets": [ [ 667, 700 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T49", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 795, 801 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T50", "type": "Condition", "text": [ "bleeding disorder" ], "offsets": [ [ 802, 819 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T51", "type": "Condition", "text": [ "intracranial hemorrhage" ], "offsets": [ [ 829, 852 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T52", "type": "Condition", "text": [ "upper gastrointestinal bleeding" ], "offsets": [ [ 854, 885 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T53", "type": "Condition", "text": [ "hematuria" ], "offsets": [ [ 887, 896 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T54", "type": "Scope", "text": [ "intracranial hemorrhage, upper gastrointestinal bleeding, hematuria" ], "offsets": [ [ 829, 896 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T55", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 918, 927 ] ], "normalized": [] }, { "id": "NCT03623789_exc_T56", "type": "Drug", "text": [ "materials of bovine origin" ], "offsets": [ [ 931, 957 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03623789_exc_R1", "type": "Has_value", "arg1_id": "NCT03623789_exc_T2", "arg2_id": "NCT03623789_exc_T3", "normalized": [] }, { "id": "NCT03623789_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03623789_exc_T2", "arg2_id": "NCT03623789_exc_T1", "normalized": [] }, { "id": "NCT03623789_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03623789_exc_T7", "arg2_id": "NCT03623789_exc_T6", "normalized": [] }, { "id": "NCT03623789_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03623789_exc_T7", "arg2_id": "NCT03623789_exc_T8", "normalized": [] }, { "id": "NCT03623789_exc_R5", "type": "Has_value", "arg1_id": "NCT03623789_exc_T10", "arg2_id": "NCT03623789_exc_T11", "normalized": [] }, { "id": "NCT03623789_exc_R6", "type": "Subsumes", "arg1_id": "NCT03623789_exc_T9", "arg2_id": "NCT03623789_exc_T12", "normalized": [] }, { "id": "NCT03623789_exc_R7", "type": "Has_value", "arg1_id": "NCT03623789_exc_T13", "arg2_id": "NCT03623789_exc_T14", "normalized": [] }, { "id": "NCT03623789_exc_R8", "type": "Has_value", "arg1_id": "NCT03623789_exc_T15", "arg2_id": "NCT03623789_exc_T16", "normalized": [] }, { "id": "NCT03623789_exc_R9", "type": "Has_value", "arg1_id": "NCT03623789_exc_T21", "arg2_id": "NCT03623789_exc_T20", "normalized": [] }, { "id": "NCT03623789_exc_R10", "type": "Has_multiplier", "arg1_id": "NCT03623789_exc_T24", "arg2_id": "NCT03623789_exc_T23", "normalized": [] }, { "id": "NCT03623789_exc_R11", "type": "Has_scope", "arg1_id": "NCT03623789_exc_T29", "arg2_id": "NCT03623789_exc_T33", "normalized": [] }, { "id": "NCT03623789_exc_R12", "type": "Subsumes", "arg1_id": "NCT03623789_exc_T34", "arg2_id": "NCT03623789_exc_T39", "normalized": [] }, { "id": "NCT03623789_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03623789_exc_T40", "arg2_id": "NCT03623789_exc_T41", "normalized": [] }, { "id": "NCT03623789_exc_R14", "type": "Subsumes", "arg1_id": "NCT03623789_exc_T44", "arg2_id": "NCT03623789_exc_T47", "normalized": [] }, { "id": "NCT03623789_exc_R15", "type": "AND", "arg1_id": "NCT03623789_exc_T48", "arg2_id": "NCT03623789_exc_T44", "normalized": [] }, { "id": "NCT03623789_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT03623789_exc_T50", "arg2_id": "NCT03623789_exc_T49", "normalized": [] }, { "id": "NCT03623789_exc_R17", "type": "Subsumes", "arg1_id": "NCT03623789_exc_T50", "arg2_id": "NCT03623789_exc_T54", "normalized": [] }, { "id": "NCT03623789_exc_R18", "type": "AND", "arg1_id": "NCT03623789_exc_T55", "arg2_id": "NCT03623789_exc_T56", "normalized": [] } ]

[ { "id": "NCT03623789_inc_text", "type": "inclusion", "text": [ "Patients with osteoarthritis of the hip secondary to degeneration, inflammatory arthritis, gouty arthritis, acetabular dysplasia or osteonecrosis of the femoral head, and undergoing primary unilateral minimally invasive THA\nAge > 18 years and < 90 years\nFailure of medical treatment or rehabilitation.\nHemoglobin > 11g/dl,\nNo use of non-steroid anti-inflammatory agent one week before operation\n" ], "offsets": [ [ 0, 395 ] ] } ]

[ { "id": "NCT03623789_inc_T1", "type": "Condition", "text": [ "osteoarthritis" ], "offsets": [ [ 14, 28 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T2", "type": "Qualifier", "text": [ "hip" ], "offsets": [ [ 36, 39 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T3", "type": "Qualifier", "text": [ "secondary to degeneration" ], "offsets": [ [ 40, 65 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T4", "type": "Condition", "text": [ "degeneration" ], "offsets": [ [ 53, 65 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T5", "type": "Condition", "text": [ "inflammatory arthritis" ], "offsets": [ [ 67, 89 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T6", "type": "Condition", "text": [ "gouty arthritis" ], "offsets": [ [ 91, 106 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T7", "type": "Condition", "text": [ "acetabular dysplasia" ], "offsets": [ [ 108, 128 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T8", "type": "Condition", "text": [ "osteonecrosis" ], "offsets": [ [ 132, 145 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T9", "type": "Qualifier", "text": [ "femoral head" ], "offsets": [ [ 153, 165 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T10", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 171, 181 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T11", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 182, 189 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T12", "type": "Qualifier", "text": [ "unilateral" ], "offsets": [ [ 190, 200 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T13", "type": "Procedure", "text": [ "minimally invasive THA" ], "offsets": [ [ 201, 223 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T14", "type": "Scope", "text": [ "acetabular dysplasia or osteonecrosis" ], "offsets": [ [ 108, 145 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T15", "type": "Person", "text": [ "Age" ], "offsets": [ [ 224, 227 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T16", "type": "Value", "text": [ "> 18 years" ], "offsets": [ [ 228, 238 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T17", "type": "Value", "text": [ "< 90 years" ], "offsets": [ [ 243, 253 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T18", "type": "Qualifier", "text": [ "Failure" ], "offsets": [ [ 254, 261 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T19", "type": "Procedure", "text": [ "medical treatment" ], "offsets": [ [ 265, 282 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T20", "type": "Procedure", "text": [ "rehabilitation" ], "offsets": [ [ 286, 300 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T21", "type": "Scope", "text": [ "medical treatment or rehabilitation" ], "offsets": [ [ 265, 300 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T22", "type": "Measurement", "text": [ "Hemoglobin" ], "offsets": [ [ 302, 312 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T23", "type": "Value", "text": [ "> 11g/dl" ], "offsets": [ [ 313, 321 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T24", "type": "Drug", "text": [ "non-steroid anti-inflammatory agent" ], "offsets": [ [ 333, 368 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T25", "type": "Temporal", "text": [ "one week before operation" ], "offsets": [ [ 369, 394 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T26", "type": "Reference_point", "text": [ "operation" ], "offsets": [ [ 385, 394 ] ], "normalized": [] }, { "id": "NCT03623789_inc_T27", "type": "Negation", "text": [ "No" ], "offsets": [ [ 323, 325 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03623789_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03623789_inc_T1", "arg2_id": "NCT03623789_inc_T2", "normalized": [] }, { "id": "NCT03623789_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03623789_inc_T1", "arg2_id": "NCT03623789_inc_T3", "normalized": [] }, { "id": "NCT03623789_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03623789_inc_T13", "arg2_id": "NCT03623789_inc_T12", "normalized": [] }, { "id": "NCT03623789_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03623789_inc_T13", "arg2_id": "NCT03623789_inc_T11", "normalized": [] }, { "id": "NCT03623789_inc_R7", "type": "Has_temporal", "arg1_id": "NCT03623789_inc_T13", "arg2_id": "NCT03623789_inc_T10", "normalized": [] }, { "id": "NCT03623789_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03623789_inc_T14", "arg2_id": "NCT03623789_inc_T9", "normalized": [] }, { "id": "NCT03623789_inc_R8", "type": "Has_value", "arg1_id": "NCT03623789_inc_T15", "arg2_id": "NCT03623789_inc_T16", "normalized": [] }, { "id": "NCT03623789_inc_R9", "type": "Has_value", "arg1_id": "NCT03623789_inc_T15", "arg2_id": "NCT03623789_inc_T17", "normalized": [] }, { "id": "NCT03623789_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT03623789_inc_T21", "arg2_id": "NCT03623789_inc_T18", "normalized": [] }, { "id": "NCT03623789_inc_R11", "type": "Has_value", "arg1_id": "NCT03623789_inc_T22", "arg2_id": "NCT03623789_inc_T23", "normalized": [] }, { "id": "NCT03623789_inc_R12", "type": "Has_index", "arg1_id": "NCT03623789_inc_T25", "arg2_id": "NCT03623789_inc_T26", "normalized": [] }, { "id": "NCT03623789_inc_R13", "type": "Has_temporal", "arg1_id": "NCT03623789_inc_T24", "arg2_id": "NCT03623789_inc_T25", "normalized": [] }, { "id": "NCT03623789_inc_R14", "type": "Has_negation", "arg1_id": "NCT03623789_inc_T24", "arg2_id": "NCT03623789_inc_T27", "normalized": [] } ]

[ { "id": "NCT03624517_exc_text", "type": "exclusion", "text": [ "Known upper gastrointestinal malignancy\nBleeding from gastric varices, with or without esophageal varices\nUse of any other endoscopic method to stop GI bleeding beyond endoscopic band ligation\nVariceal bleeding in the last 90 days\nHistory of transjugular, intrahepatic, portosystemic shunt (TIPS) or vascular decompression surgery\nPregnant females\nIncarcerated individuals\nMyocardial infarct, cerebrovascular accident, sepsis, respiratory failure, or severe intercurrent illness within the previous 6 weeks\nNon-cirrhotic portal hypertension causing esophageal varices\nKnown or suspected allergy to octreotide\n" ], "offsets": [ [ 0, 609 ] ] } ]

[ { "id": "NCT03624517_exc_T1", "type": "Condition", "text": [ "upper gastrointestinal malignancy" ], "offsets": [ [ 6, 39 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T2", "type": "Condition", "text": [ "Bleeding" ], "offsets": [ [ 40, 48 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T3", "type": "Condition", "text": [ "gastric varices" ], "offsets": [ [ 54, 69 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T4", "type": "Condition", "text": [ "esophageal varices" ], "offsets": [ [ 87, 105 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T5", "type": "Negation", "text": [ "any other" ], "offsets": [ [ 113, 122 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T6", "type": "Procedure", "text": [ "endoscopic method" ], "offsets": [ [ 123, 140 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T7", "type": "Condition", "text": [ "GI bleeding" ], "offsets": [ [ 149, 160 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T8", "type": "Procedure", "text": [ "endoscopic band ligation" ], "offsets": [ [ 168, 192 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T9", "type": "Condition", "text": [ "Variceal bleeding" ], "offsets": [ [ 193, 210 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T10", "type": "Temporal", "text": [ "in the last 90 days" ], "offsets": [ [ 211, 230 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T11", "type": "Procedure", "text": [ "transjugular, intrahepatic, portosystemic shunt (TIPS)" ], "offsets": [ [ 242, 296 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T12", "type": "Procedure", "text": [ "vascular decompression surgery" ], "offsets": [ [ 300, 330 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T13", "type": "Observation", "text": [ "History" ], "offsets": [ [ 231, 238 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T14", "type": "Scope", "text": [ "transjugular, intrahepatic, portosystemic shunt (TIPS) or vascular decompression surgery" ], "offsets": [ [ 242, 330 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T15", "type": "Person", "text": [ "females" ], "offsets": [ [ 340, 347 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T16", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 331, 339 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T17", "type": "Person", "text": [ "Incarcerated individuals" ], "offsets": [ [ 348, 372 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T18", "type": "Condition", "text": [ "Myocardial infarct" ], "offsets": [ [ 373, 391 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T19", "type": "Condition", "text": [ "cerebrovascular accident" ], "offsets": [ [ 393, 417 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T20", "type": "Condition", "text": [ "sepsis" ], "offsets": [ [ 419, 425 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T21", "type": "Condition", "text": [ "respiratory failure" ], "offsets": [ [ 427, 446 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T22", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 451, 457 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T23", "type": "Condition", "text": [ "intercurrent illness" ], "offsets": [ [ 458, 478 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T24", "type": "Temporal", "text": [ "within the previous 6 weeks" ], "offsets": [ [ 479, 506 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T25", "type": "Scope", "text": [ "Myocardial infarct, cerebrovascular accident, sepsis, respiratory failure, or severe intercurrent illness" ], "offsets": [ [ 373, 478 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T26", "type": "Condition", "text": [ "Non-cirrhotic portal hypertension" ], "offsets": [ [ 507, 540 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T27", "type": "Condition", "text": [ "esophageal varices" ], "offsets": [ [ 549, 567 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T28", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 587, 594 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T29", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 577, 586 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T30", "type": "Mood", "text": [ "Known" ], "offsets": [ [ 568, 573 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T31", "type": "Scope", "text": [ "Known or suspected" ], "offsets": [ [ 568, 586 ] ], "normalized": [] }, { "id": "NCT03624517_exc_T32", "type": "Drug", "text": [ "octreotide" ], "offsets": [ [ 598, 608 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03624517_exc_R1", "type": "AND", "arg1_id": "NCT03624517_exc_T2", "arg2_id": "NCT03624517_exc_T3", "normalized": [] }, { "id": "NCT03624517_exc_R2", "type": "AND", "arg1_id": "NCT03624517_exc_T2", "arg2_id": "NCT03624517_exc_T4", "normalized": [] }, { "id": "NCT03624517_exc_R3", "type": "Has_negation", "arg1_id": "NCT03624517_exc_T8", "arg2_id": "NCT03624517_exc_T5", "normalized": [] }, { "id": "NCT03624517_exc_R4", "type": "AND", "arg1_id": "NCT03624517_exc_T6", "arg2_id": "NCT03624517_exc_T8", "normalized": [] }, { "id": "NCT03624517_exc_R5", "type": "AND", "arg1_id": "NCT03624517_exc_T6", "arg2_id": "NCT03624517_exc_T7", "normalized": [] }, { "id": "NCT03624517_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03624517_exc_T9", "arg2_id": "NCT03624517_exc_T10", "normalized": [] }, { "id": "NCT03624517_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03624517_exc_T14", "arg2_id": "NCT03624517_exc_T13", "normalized": [] }, { "id": "NCT03624517_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03624517_exc_T23", "arg2_id": "NCT03624517_exc_T22", "normalized": [] }, { "id": "NCT03624517_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03624517_exc_T25", "arg2_id": "NCT03624517_exc_T24", "normalized": [] }, { "id": "NCT03624517_exc_R10", "type": "AND", "arg1_id": "NCT03624517_exc_T26", "arg2_id": "NCT03624517_exc_T27", "normalized": [] }, { "id": "NCT03624517_exc_R11", "type": "Has_scope", "arg1_id": "NCT03624517_exc_T28", "arg2_id": "NCT03624517_exc_T31", "normalized": [] }, { "id": "NCT03624517_exc_R12", "type": "AND", "arg1_id": "NCT03624517_exc_T28", "arg2_id": "NCT03624517_exc_T32", "normalized": [] } ]

[ { "id": "NCT03624517_inc_text", "type": "inclusion", "text": [ "Adult males and females who are 18 years of age or older.\nEvidence or suspicion of upper gastrointestinal bleed (GIB)\nPatient with known or suspected cirrhosis\nUpper GIB secondary to bleeding esophageal varices as show by esophageal endoscopy, requiring endoscopic band ligation (EBL) at presentation\nWilling and able to provide informed consent for study, or have a Legally authorized representative (LAR) provide consent if the patient is unable to do so\n" ], "offsets": [ [ 0, 457 ] ] } ]

[ { "id": "NCT03624517_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T2", "type": "Person", "text": [ "males" ], "offsets": [ [ 6, 11 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T3", "type": "Person", "text": [ "females" ], "offsets": [ [ 16, 23 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T4", "type": "Value", "text": [ "18 years of age or older" ], "offsets": [ [ 32, 56 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T5", "type": "Mood", "text": [ "suspicion" ], "offsets": [ [ 70, 79 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T6", "type": "Mood", "text": [ "Evidence" ], "offsets": [ [ 58, 66 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T7", "type": "Condition", "text": [ "upper gastrointestinal bleed (GIB)" ], "offsets": [ [ 83, 117 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T8", "type": "Scope", "text": [ "Evidence or suspicion" ], "offsets": [ [ 58, 79 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T9", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 140, 149 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T10", "type": "Mood", "text": [ "known" ], "offsets": [ [ 131, 136 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T11", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 150, 159 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T12", "type": "Scope", "text": [ "known or suspected" ], "offsets": [ [ 131, 149 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T13", "type": "Condition", "text": [ "Upper GIB" ], "offsets": [ [ 160, 169 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T14", "type": "Qualifier", "text": [ "secondary" ], "offsets": [ [ 170, 179 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T15", "type": "Qualifier", "text": [ "bleeding" ], "offsets": [ [ 183, 191 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T16", "type": "Condition", "text": [ "esophageal varices" ], "offsets": [ [ 192, 210 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T17", "type": "Procedure", "text": [ "esophageal endoscopy" ], "offsets": [ [ 222, 242 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T18", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 244, 253 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T19", "type": "Procedure", "text": [ "endoscopic band ligation (EBL)" ], "offsets": [ [ 254, 284 ] ], "normalized": [] }, { "id": "NCT03624517_inc_T20", "type": "Temporal", "text": [ "at presentation" ], "offsets": [ [ 285, 300 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03624517_inc_R1", "type": "Has_scope", "arg1_id": "NCT03624517_inc_T7", "arg2_id": "NCT03624517_inc_T8", "normalized": [] }, { "id": "NCT03624517_inc_R2", "type": "Has_scope", "arg1_id": "NCT03624517_inc_T11", "arg2_id": "NCT03624517_inc_T12", "normalized": [] }, { "id": "NCT03624517_inc_R3", "type": "AND", "arg1_id": "NCT03624517_inc_T14", "arg2_id": "NCT03624517_inc_T16", "normalized": [] }, { "id": "NCT03624517_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03624517_inc_T13", "arg2_id": "NCT03624517_inc_T14", "normalized": [] }, { "id": "NCT03624517_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03624517_inc_T16", "arg2_id": "NCT03624517_inc_T15", "normalized": [] }, { "id": "NCT03624517_inc_R6", "type": "AND", "arg1_id": "NCT03624517_inc_T16", "arg2_id": "NCT03624517_inc_T17", "normalized": [] }, { "id": "NCT03624517_inc_R7", "type": "Has_mood", "arg1_id": "NCT03624517_inc_T19", "arg2_id": "NCT03624517_inc_T18", "normalized": [] }, { "id": "NCT03624517_inc_R8", "type": "AND", "arg1_id": "NCT03624517_inc_T16", "arg2_id": "NCT03624517_inc_T19", "normalized": [] }, { "id": "NCT03624517_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03624517_inc_T19", "arg2_id": "NCT03624517_inc_T20", "normalized": [] } ]

[ { "id": "NCT03624881_exc_text", "type": "exclusion", "text": [ "Previous surgical or catheter ablation for atrial fibrillation\nPrevious cardiac surgery (including CABG) within the past 6 months (180 days)\nValvular cardiac surgical/percutaneous procedure (i.e., ventriculotomy, atriotomy, and valve repair or replacement and presence of a prosthetic valve)\nAny carotid stenting or endarterectomy\nDocumented LA thrombus on imaging\nLA size > 50 mm (parasternal long axis view)\nLVEF < 40%\nContraindication to anticoagulation (heparin or warfarin)\nHistory of blood clotting or bleeding abnormalities\nPCI/MI within the past 2 months (60 days)\nDocumented thromboembolic event (including TIA) within the past 12 months (365 days)\nRheumatic Heart Disease\nUncontrolled heart failure or NYHA function class III or IV\nSevere mitral regurgitation (Regurgitant volume = 60 mL/beat, Regurgitant fraction = 50%, and/or Effective regurgitant orifice area = 0.40cm2)\nAwaiting cardiac transplantation or other cardiac surgery within the next 12 months (365 days)\nUnstable angina\nAcute illness or active systemic infection or sepsis\nAF secondary to electrolyte imbalance, thyroid disease, or reversible or non-cardiac cause.\nPresence of implanted ICD/CRT-D.\nSignificant pulmonary disease, (e.g., restrictive pulmonary disease, constrictive or chronic obstructive pulmonary disease) or any other disease or malfunction of the lungs or respiratory system that produces chronic symptoms.\nGastroesophageal Reflux Disease (GERD; active requiring significant intervention not including OTC medication)\nSignificant congenital anomaly or medical problem that in the opinion of the investigator would preclude enrollment in this study.\nWomen who are pregnant (as evidenced by pregnancy test if pre-menopausal)\nConcurrent enrollment in an investigational study evaluating another device, biologic, or drug.\nPresence of intracardiac thrombus, myxoma, tumor, interatrial baffle or patch or other abnormality that precludes vascular access, or manipulation of the catheter.\nLife expectancy less than 12 months\n" ], "offsets": [ [ 0, 2013 ] ] } ]

[ { "id": "NCT03624881_exc_T1", "type": "Procedure", "text": [ "catheter ablation" ], "offsets": [ [ 21, 38 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T2", "type": "Procedure", "text": [ "ablation", "surgical" ], "offsets": [ [ 30, 38 ], [ 9, 17 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T3", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 43, 62 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T4", "type": "Scope", "text": [ "surgical or catheter ablation" ], "offsets": [ [ 9, 38 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T5", "type": "Procedure", "text": [ "cardiac surgery" ], "offsets": [ [ 72, 87 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T6", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T7", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 63, 71 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T8", "type": "Procedure", "text": [ "CABG" ], "offsets": [ [ 99, 103 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T9", "type": "Temporal", "text": [ "within the past 6 months (180 days)" ], "offsets": [ [ 105, 140 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T10", "type": "Procedure", "text": [ "lvular cardiac s", "rcutaneous procedure (" ], "offsets": [ [ 143, 159 ], [ 169, 191 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T11", "type": "Procedure", "text": [ "lvular cardiac surgical/p", "ocedure (" ], "offsets": [ [ 143, 168 ], [ 182, 191 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T12", "type": "Procedure", "text": [ "ventriculotomy" ], "offsets": [ [ 197, 211 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T13", "type": "Procedure", "text": [ "atriotomy" ], "offsets": [ [ 213, 222 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T14", "type": "Procedure", "text": [ "valve repair" ], "offsets": [ [ 228, 240 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T15", "type": "Procedure", "text": [ "lve r", "placement a" ], "offsets": [ [ 230, 235 ], [ 246, 257 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T16", "type": "Device", "text": [ "prosthetic valve" ], "offsets": [ [ 274, 290 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T17", "type": "Scope", "text": [ "ventriculotomy, atriotomy, and valve repair or replacement and presence of a prosthetic valve" ], "offsets": [ [ 197, 290 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T18", "type": "Scope", "text": [ "Valvular cardiac surgical/percutaneous procedure" ], "offsets": [ [ 141, 189 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T19", "type": "Device", "text": [ "carotid stenting" ], "offsets": [ [ 296, 312 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T20", "type": "Procedure", "text": [ "endarterectomy" ], "offsets": [ [ 316, 330 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T21", "type": "Condition", "text": [ "LA thrombus" ], "offsets": [ [ 342, 353 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T22", "type": "Procedure", "text": [ "imaging" ], "offsets": [ [ 357, 364 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T23", "type": "Measurement", "text": [ "LA size" ], "offsets": [ [ 365, 372 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T24", "type": "Value", "text": [ "> 50 mm" ], "offsets": [ [ 373, 380 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T25", "type": "Qualifier", "text": [ "parasternal long axis view" ], "offsets": [ [ 382, 408 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T26", "type": "Measurement", "text": [ "LVEF" ], "offsets": [ [ 410, 414 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T27", "type": "Value", "text": [ "< 40%" ], "offsets": [ [ 415, 420 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T28", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 421, 437 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T29", "type": "Drug", "text": [ "anticoagulation" ], "offsets": [ [ 441, 456 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T30", "type": "Drug", "text": [ "heparin" ], "offsets": [ [ 458, 465 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T31", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 469, 477 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T32", "type": "Scope", "text": [ "heparin or warfarin" ], "offsets": [ [ 458, 477 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T33", "type": "Scope", "text": [ "Contraindication to anticoagulation" ], "offsets": [ [ 421, 456 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T34", "type": "Observation", "text": [ "History" ], "offsets": [ [ 479, 486 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T35", "type": "Condition", "text": [ "blood clotting" ], "offsets": [ [ 490, 504 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T36", "type": "Condition", "text": [ "bleeding abnormalities" ], "offsets": [ [ 508, 530 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T37", "type": "Scope", "text": [ "blood clotting or bleeding abnormalities" ], "offsets": [ [ 490, 530 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T38", "type": "Condition", "text": [ "MI" ], "offsets": [ [ 535, 537 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T39", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 531, 534 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T40", "type": "Temporal", "text": [ "within the past 2 months" ], "offsets": [ [ 538, 562 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T41", "type": "Temporal", "text": [ "e past 2 months", "Documen" ], "offsets": [ [ 547, 562 ], [ 573, 580 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T42", "type": "Scope", "text": [ "within the past 2 months (60 days)" ], "offsets": [ [ 538, 572 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T43", "type": "Scope", "text": [ "PCI/MI" ], "offsets": [ [ 531, 537 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T44", "type": "Condition", "text": [ "thromboembolic event" ], "offsets": [ [ 584, 604 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T45", "type": "Condition", "text": [ "TIA" ], "offsets": [ [ 616, 619 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T46", "type": "Temporal", "text": [ "within the past 12 months" ], "offsets": [ [ 621, 646 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T47", "type": "Temporal", "text": [ " past 12 month", "Rheumati" ], "offsets": [ [ 631, 645 ], [ 658, 666 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T48", "type": "Scope", "text": [ "within the past 12 months (365 days)" ], "offsets": [ [ 621, 657 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T49", "type": "Scope", "text": [ "thromboembolic event (including TIA)" ], "offsets": [ [ 584, 620 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T50", "type": "Condition", "text": [ "Rheumatic Heart Disease" ], "offsets": [ [ 658, 681 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T51", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 682, 694 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T52", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 695, 708 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T53", "type": "Measurement", "text": [ "NYHA function class" ], "offsets": [ [ 712, 731 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T54", "type": "Value", "text": [ "III" ], "offsets": [ [ 732, 735 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T55", "type": "Value", "text": [ "IV" ], "offsets": [ [ 739, 741 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T56", "type": "Scope", "text": [ "III or IV" ], "offsets": [ [ 732, 741 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T57", "type": "Scope", "text": [ "NYHA function class III or IV" ], "offsets": [ [ 712, 741 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T58", "type": "Condition", "text": [ "mitral regurgitation" ], "offsets": [ [ 749, 769 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T59", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 742, 748 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T62", "type": "Measurement", "text": [ "Regurgitant volume" ], "offsets": [ [ 771, 789 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T63", "type": "Value", "text": [ "= 60 mL/beat" ], "offsets": [ [ 790, 802 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T60", "type": "Measurement", "text": [ "Regurgitant fraction" ], "offsets": [ [ 804, 824 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T61", "type": "Value", "text": [ "= 50%" ], "offsets": [ [ 825, 830 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T64", "type": "Measurement", "text": [ "Effective regurgitant orifice area" ], "offsets": [ [ 839, 873 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T65", "type": "Value", "text": [ "= 0.40cm2" ], "offsets": [ [ 874, 883 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T66", "type": "Scope", "text": [ "Regurgitant volume = 60 mL/beat, Regurgitant fraction = 50%, and/or Effective regurgitant orifice area = 0.40cm2" ], "offsets": [ [ 771, 883 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T67", "type": "Scope", "text": [ "Severe mitral regurgitation" ], "offsets": [ [ 742, 769 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T68", "type": "Procedure", "text": [ "cardiac transplantation" ], "offsets": [ [ 894, 917 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T69", "type": "Procedure", "text": [ "cardiac surgery" ], "offsets": [ [ 927, 942 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T70", "type": "Temporal", "text": [ "within the next 12 months" ], "offsets": [ [ 943, 968 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T71", "type": "Temporal", "text": [ "t 12 months (36", "able ang" ], "offsets": [ [ 957, 972 ], [ 984, 992 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T72", "type": "Scope", "text": [ "cardiac transplantation or other cardiac surgery" ], "offsets": [ [ 894, 942 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T73", "type": "Condition", "text": [ "Unstable angina" ], "offsets": [ [ 980, 995 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T74", "type": "Condition", "text": [ "Acute illness" ], "offsets": [ [ 996, 1009 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T75", "type": "Condition", "text": [ "systemic infection" ], "offsets": [ [ 1020, 1038 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T76", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1013, 1019 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T77", "type": "Condition", "text": [ "sepsis" ], "offsets": [ [ 1042, 1048 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T78", "type": "Condition", "text": [ "AF" ], "offsets": [ [ 1049, 1051 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T79", "type": "Condition", "text": [ "electrolyte imbalance" ], "offsets": [ [ 1065, 1086 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T80", "type": "Qualifier", "text": [ "secondary" ], "offsets": [ [ 1052, 1061 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T81", "type": "Condition", "text": [ "thyroid disease" ], "offsets": [ [ 1088, 1103 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T82", "type": "Condition", "text": [ "non-cardiac cause" ], "offsets": [ [ 1122, 1139 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T83", "type": "Qualifier", "text": [ "reversible" ], "offsets": [ [ 1108, 1118 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T84", "type": "Device", "text": [ "implanted ICD/CRT-D" ], "offsets": [ [ 1153, 1172 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T85", "type": "Condition", "text": [ "pulmonary disease" ], "offsets": [ [ 1186, 1203 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T86", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1174, 1185 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T87", "type": "Condition", "text": [ "restrictive pulmonary disease" ], "offsets": [ [ 1212, 1241 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T88", "type": "Condition", "text": [ "chronic obstructive pulmonary disease" ], "offsets": [ [ 1259, 1296 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T89", "type": "Condition", "text": [ "onic obstruc", "or any other dise" ], "offsets": [ [ 1262, 1274 ], [ 1298, 1315 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T90", "type": "Scope", "text": [ "restrictive pulmonary disease, constrictive or chronic obstructive pulmonary disease" ], "offsets": [ [ 1212, 1296 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T91", "type": "Scope", "text": [ "Significant pulmonary disease" ], "offsets": [ [ 1174, 1203 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T92", "type": "Qualifier", "text": [ "any other" ], "offsets": [ [ 1301, 1310 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T93", "type": "Condition", "text": [ "ion of", "piratory sys" ], "offsets": [ [ 1330, 1336 ], [ 1353, 1365 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T94", "type": "Condition", "text": [ "malfunction of the lungs" ], "offsets": [ [ 1322, 1346 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T95", "type": "Scope", "text": [ "disease or malfunction of the lungs or respiratory system" ], "offsets": [ [ 1311, 1368 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T96", "type": "Condition", "text": [ "ion of", "pirato", "that produces chro" ], "offsets": [ [ 1330, 1336 ], [ 1353, 1359 ], [ 1369, 1387 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T97", "type": "Condition", "text": [ "chronic symptoms" ], "offsets": [ [ 1383, 1399 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T98", "type": "Condition", "text": [ "Gastroesophageal Reflux Disease" ], "offsets": [ [ 1401, 1432 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T99", "type": "Condition", "text": [ "GERD" ], "offsets": [ [ 1434, 1438 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T100", "type": "Procedure", "text": [ "significant intervention" ], "offsets": [ [ 1457, 1481 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T101", "type": "Drug", "text": [ "OTC medication" ], "offsets": [ [ 1496, 1510 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T102", "type": "Negation", "text": [ "not" ], "offsets": [ [ 1482, 1485 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T103", "type": "Condition", "text": [ "congenital anomaly" ], "offsets": [ [ 1524, 1542 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T104", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1512, 1523 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T105", "type": "Condition", "text": [ "medical problem" ], "offsets": [ [ 1546, 1561 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T107", "type": "Person", "text": [ "Women" ], "offsets": [ [ 1643, 1648 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T108", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 1657, 1665 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T109", "type": "Procedure", "text": [ "pregnancy test" ], "offsets": [ [ 1683, 1697 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T110", "type": "Condition", "text": [ "pre-menopausal" ], "offsets": [ [ 1701, 1715 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T112", "type": "Condition", "text": [ "intracardiac thrombus" ], "offsets": [ [ 1825, 1846 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T113", "type": "Condition", "text": [ "myxoma" ], "offsets": [ [ 1848, 1854 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T114", "type": "Condition", "text": [ "tumor" ], "offsets": [ [ 1856, 1861 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T115", "type": "Condition", "text": [ "interatrial baffle" ], "offsets": [ [ 1863, 1881 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T116", "type": "Device", "text": [ "patch" ], "offsets": [ [ 1885, 1890 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T117", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 1894, 1899 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T118", "type": "Condition", "text": [ "abnormality" ], "offsets": [ [ 1900, 1911 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T119", "type": "Procedure", "text": [ "vascular access" ], "offsets": [ [ 1927, 1942 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T120", "type": "Procedure", "text": [ "manipulation of the catheter" ], "offsets": [ [ 1947, 1975 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T121", "type": "Condition", "text": [ "precludes" ], "offsets": [ [ 1917, 1926 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T122", "type": "Scope", "text": [ "vascular access, or manipulation of the catheter" ], "offsets": [ [ 1927, 1975 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T123", "type": "Observation", "text": [ "Life expectancy" ], "offsets": [ [ 1977, 1992 ] ], "normalized": [] }, { "id": "NCT03624881_exc_T124", "type": "Value", "text": [ "less than 12 months" ], "offsets": [ [ 1993, 2012 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03624881_exc_R1", "type": "AND", "arg1_id": "NCT03624881_exc_T4", "arg2_id": "NCT03624881_exc_T3", "normalized": [] }, { "id": "NCT03624881_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03624881_exc_T4", "arg2_id": "NCT03624881_exc_T6", "normalized": [] }, { "id": "NCT03624881_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03624881_exc_T5", "arg2_id": "NCT03624881_exc_T7", "normalized": [] }, { "id": "NCT03624881_exc_R4", "type": "Subsumes", "arg1_id": "NCT03624881_exc_T5", "arg2_id": "NCT03624881_exc_T8", "normalized": [] }, { "id": "NCT03624881_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03624881_exc_T5", "arg2_id": "NCT03624881_exc_T9", "normalized": [] }, { "id": "NCT03624881_exc_R6", "type": "Subsumes", "arg1_id": "NCT03624881_exc_T18", "arg2_id": "NCT03624881_exc_T17", "normalized": [] }, { "id": "NCT03624881_exc_R7", "type": "AND", "arg1_id": "NCT03624881_exc_T22", "arg2_id": "NCT03624881_exc_T21", "normalized": [] }, { "id": "NCT03624881_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03624881_exc_T23", "arg2_id": "NCT03624881_exc_T25", "normalized": [] }, { "id": "NCT03624881_exc_R9", "type": "Has_value", "arg1_id": "NCT03624881_exc_T23", "arg2_id": "NCT03624881_exc_T24", "normalized": [] }, { "id": "NCT03624881_exc_R10", "type": "Has_value", "arg1_id": "NCT03624881_exc_T26", "arg2_id": "NCT03624881_exc_T27", "normalized": [] }, { "id": "NCT03624881_exc_R11", "type": "AND", "arg1_id": "NCT03624881_exc_T28", "arg2_id": "NCT03624881_exc_T29", "normalized": [] }, { "id": "NCT03624881_exc_R12", "type": "Subsumes", "arg1_id": "NCT03624881_exc_T33", "arg2_id": "NCT03624881_exc_T32", "normalized": [] }, { "id": "NCT03624881_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03624881_exc_T37", "arg2_id": "NCT03624881_exc_T34", "normalized": [] }, { "id": "NCT03624881_exc_R14", "type": "Subsumes", "arg1_id": "NCT03624881_exc_T43", "arg2_id": "NCT03624881_exc_T42", "normalized": [] }, { "id": "NCT03624881_exc_R15", "type": "Subsumes", "arg1_id": "NCT03624881_exc_T44", "arg2_id": "NCT03624881_exc_T45", "normalized": [] }, { "id": "NCT03624881_exc_R16", "type": "Has_scope", "arg1_id": "NCT03624881_exc_T49", "arg2_id": "NCT03624881_exc_T48", "normalized": [] }, { "id": "NCT03624881_exc_R17", "type": "Has_scope", "arg1_id": "NCT03624881_exc_T53", "arg2_id": "NCT03624881_exc_T56", "normalized": [] }, { "id": "NCT03624881_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT03624881_exc_T52", "arg2_id": "NCT03624881_exc_T51", "normalized": [] }, { "id": "NCT03624881_exc_R19", "type": "Has_scope", "arg1_id": "NCT03624881_exc_T52", "arg2_id": "NCT03624881_exc_T57", "normalized": [] }, { "id": "NCT03624881_exc_R20", "type": "Has_qualifier", "arg1_id": "NCT03624881_exc_T58", "arg2_id": "NCT03624881_exc_T59", "normalized": [] }, { "id": "NCT03624881_exc_R21", "type": "Has_value", "arg1_id": "NCT03624881_exc_T62", "arg2_id": "NCT03624881_exc_T63", "normalized": [] }, { "id": "NCT03624881_exc_R22", "type": "Has_value", "arg1_id": "NCT03624881_exc_T60", "arg2_id": "NCT03624881_exc_T61", "normalized": [] }, { "id": "NCT03624881_exc_R23", "type": "Has_value", "arg1_id": "NCT03624881_exc_T64", "arg2_id": "NCT03624881_exc_T65", "normalized": [] }, { "id": "NCT03624881_exc_R24", "type": "Has_scope", "arg1_id": "NCT03624881_exc_T67", "arg2_id": "NCT03624881_exc_T66", "normalized": [] }, { "id": "NCT03624881_exc_R25", "type": "Subsumes", "arg1_id": "NCT03624881_exc_T70", "arg2_id": "NCT03624881_exc_T71", "normalized": [] }, { "id": "NCT03624881_exc_R26", "type": "Has_temporal", "arg1_id": "NCT03624881_exc_T72", "arg2_id": "NCT03624881_exc_T70", "normalized": [] }, { "id": "NCT03624881_exc_R27", "type": "AND", "arg1_id": "NCT03624881_exc_T80", "arg2_id": "NCT03624881_exc_T79", "normalized": [] }, { "id": "NCT03624881_exc_R28", "type": "Has_qualifier", "arg1_id": "NCT03624881_exc_T78", "arg2_id": "NCT03624881_exc_T80", "normalized": [] }, { "id": "NCT03624881_exc_R29", "type": "Has_qualifier", "arg1_id": "NCT03624881_exc_T82", "arg2_id": "NCT03624881_exc_T83", "normalized": [] }, { "id": "NCT03624881_exc_R30", "type": "Has_qualifier", "arg1_id": "NCT03624881_exc_T85", "arg2_id": "NCT03624881_exc_T86", "normalized": [] }, { "id": "NCT03624881_exc_R31", "type": "Subsumes", "arg1_id": "NCT03624881_exc_T91", "arg2_id": "NCT03624881_exc_T90", "normalized": [] }, { "id": "NCT03624881_exc_R32", "type": "Has_qualifier", "arg1_id": "NCT03624881_exc_T95", "arg2_id": "NCT03624881_exc_T92", "normalized": [] }, { "id": "NCT03624881_exc_R33", "type": "AND", "arg1_id": "NCT03624881_exc_T95", "arg2_id": "NCT03624881_exc_T97", "normalized": [] }, { "id": "NCT03624881_exc_R34", "type": "Has_negation", "arg1_id": "NCT03624881_exc_T101", "arg2_id": "NCT03624881_exc_T102", "normalized": [] }, { "id": "NCT03624881_exc_R35", "type": "AND", "arg1_id": "NCT03624881_exc_T100", "arg2_id": "NCT03624881_exc_T101", "normalized": [] }, { "id": "NCT03624881_exc_R36", "type": "Subsumes", "arg1_id": "NCT03624881_exc_T98", "arg2_id": "NCT03624881_exc_T99", "normalized": [] }, { "id": "NCT03624881_exc_R37", "type": "AND", "arg1_id": "NCT03624881_exc_T110", "arg2_id": "NCT03624881_exc_T109", "normalized": [] }, { "id": "NCT03624881_exc_R38", "type": "AND", "arg1_id": "NCT03624881_exc_T108", "arg2_id": "NCT03624881_exc_T110", "normalized": [] }, { "id": "NCT03624881_exc_R39", "type": "Has_qualifier", "arg1_id": "NCT03624881_exc_T118", "arg2_id": "NCT03624881_exc_T117", "normalized": [] }, { "id": "NCT03624881_exc_R40", "type": "Has_scope", "arg1_id": "NCT03624881_exc_T121", "arg2_id": "NCT03624881_exc_T122", "normalized": [] }, { "id": "NCT03624881_exc_R41", "type": "AND", "arg1_id": "NCT03624881_exc_T118", "arg2_id": "NCT03624881_exc_T121", "normalized": [] }, { "id": "NCT03624881_exc_R42", "type": "Has_value", "arg1_id": "NCT03624881_exc_T123", "arg2_id": "NCT03624881_exc_T124", "normalized": [] } ]

[ { "id": "NCT03624881_inc_text", "type": "inclusion", "text": [ "Symptomatic paroxysmal AF who had at least one AF episode electrocardiographically documented within one (1) year prior to enrollment. Documentation may include electrocardiogram (ECG); Transtelephonic monitoring (TTM), Holter monitor or telemetry strip\nFailed at least one antiarrhythmic drug (AAD) (Class I or III antiarrhythmic drugs) as evidenced by recurrent symptomatic AF, or intolerable to the AAD\nAge 18 years or older\nSigned Patient Informed Consent Form (ICF)\nAble and willing to comply with all pre-, post-, and follow-up testing and requirements\n" ], "offsets": [ [ 0, 559 ] ] } ]

[ { "id": "NCT03624881_inc_T1", "type": "Qualifier", "text": [ "Symptomatic" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T2", "type": "Condition", "text": [ "paroxysmal AF" ], "offsets": [ [ 12, 25 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T3", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 34, 46 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T4", "type": "Condition", "text": [ "AF episode" ], "offsets": [ [ 47, 57 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T5", "type": "Procedure", "text": [ "electrocardiographically" ], "offsets": [ [ 58, 82 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T6", "type": "Qualifier", "text": [ "electrocardiographically documented" ], "offsets": [ [ 58, 93 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T7", "type": "Temporal", "text": [ "within one (1) year prior to enrollment" ], "offsets": [ [ 94, 133 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T8", "type": "Reference_point", "text": [ "enrollment" ], "offsets": [ [ 123, 133 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T9", "type": "Procedure", "text": [ "electrocardiogram (ECG)" ], "offsets": [ [ 161, 184 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T10", "type": "Procedure", "text": [ "Transtelephonic monitoring (TTM)" ], "offsets": [ [ 186, 218 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T11", "type": "Procedure", "text": [ "Holter monitor" ], "offsets": [ [ 220, 234 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T12", "type": "Procedure", "text": [ "telemetry strip" ], "offsets": [ [ 238, 253 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T13", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 261, 273 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T14", "type": "Drug", "text": [ "antiarrhythmic drug (AAD)" ], "offsets": [ [ 274, 299 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T15", "type": "Drug", "text": [ "III antiarrhythmic drugs" ], "offsets": [ [ 312, 336 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T16", "type": "Drug", "text": [ "lass I", "ntiarrhythmic drugs)" ], "offsets": [ [ 302, 308 ], [ 317, 337 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T17", "type": "Scope", "text": [ "Class I or III antiarrhythmic drugs" ], "offsets": [ [ 301, 336 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T18", "type": "Condition", "text": [ "recurrent symptomatic AF" ], "offsets": [ [ 354, 378 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T19", "type": "Condition", "text": [ "intolerable" ], "offsets": [ [ 383, 394 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T20", "type": "Condition", "text": [ "AAD" ], "offsets": [ [ 402, 405 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T21", "type": "Person", "text": [ "Age" ], "offsets": [ [ 406, 409 ] ], "normalized": [] }, { "id": "NCT03624881_inc_T22", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 410, 427 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03624881_inc_R1", "type": "Has_index", "arg1_id": "NCT03624881_inc_T7", "arg2_id": "NCT03624881_inc_T8", "normalized": [] }, { "id": "NCT03624881_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03624881_inc_T4", "arg2_id": "NCT03624881_inc_T6", "normalized": [] }, { "id": "NCT03624881_inc_R3", "type": "Subsumes", "arg1_id": "NCT03624881_inc_T6", "arg2_id": "NCT03624881_inc_T5", "normalized": [] }, { "id": "NCT03624881_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03624881_inc_T4", "arg2_id": "NCT03624881_inc_T7", "normalized": [] }, { "id": "NCT03624881_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT03624881_inc_T4", "arg2_id": "NCT03624881_inc_T3", "normalized": [] }, { "id": "NCT03624881_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03624881_inc_T2", "arg2_id": "NCT03624881_inc_T1", "normalized": [] }, { "id": "NCT03624881_inc_R7", "type": "Subsumes", "arg1_id": "NCT03624881_inc_T14", "arg2_id": "NCT03624881_inc_T17", "normalized": [] }, { "id": "NCT03624881_inc_R8", "type": "Has_multiplier", "arg1_id": "NCT03624881_inc_T14", "arg2_id": "NCT03624881_inc_T13", "normalized": [] }, { "id": "NCT03624881_inc_R9", "type": "AND", "arg1_id": "NCT03624881_inc_T19", "arg2_id": "NCT03624881_inc_T20", "normalized": [] }, { "id": "NCT03624881_inc_R10", "type": "Has_value", "arg1_id": "NCT03624881_inc_T21", "arg2_id": "NCT03624881_inc_T22", "normalized": [] } ]

[ { "id": "NCT03631355_exc_text", "type": "exclusion", "text": [ "Legally incompetent or mentally impaired (e.g., minors, Alzheimer's subjects, dementia, etc.)\nYounger than 18 years of age\nAny patient considered a vulnerable subject\nHave bleeding or clotting disorder\nPreoperative anticoagulation therapy\nAbnormal coagulation profile\nRenal disorder or insufficiency\nSickle cell disease\n" ], "offsets": [ [ 0, 320 ] ] } ]

[ { "id": "NCT03631355_exc_T1", "type": "Observation", "text": [ "Legally incompetent" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T2", "type": "Condition", "text": [ "mentally impaired" ], "offsets": [ [ 23, 40 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T3", "type": "Person", "text": [ "minors" ], "offsets": [ [ 48, 54 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T4", "type": "Condition", "text": [ "Alzheimer's" ], "offsets": [ [ 56, 67 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T5", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 78, 86 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T6", "type": "Scope", "text": [ "minors, Alzheimer's subjects, dementia" ], "offsets": [ [ 48, 86 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T7", "type": "Scope", "text": [ "Legally incompetent or mentally impaired" ], "offsets": [ [ 0, 40 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T8", "type": "Value", "text": [ "Younger than 18 years" ], "offsets": [ [ 94, 115 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T9", "type": "Person", "text": [ "age" ], "offsets": [ [ 119, 122 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T10", "type": "Observation", "text": [ "vulnerable subject" ], "offsets": [ [ 148, 166 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T11", "type": "Condition", "text": [ "eding or", "order\nPr" ], "offsets": [ [ 175, 183 ], [ 196, 204 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T12", "type": "Condition", "text": [ "clotting disorder" ], "offsets": [ [ 184, 201 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T13", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 202, 214 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T14", "type": "Procedure", "text": [ "anticoagulation therapy" ], "offsets": [ [ 215, 238 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T15", "type": "Drug", "text": [ "anticoagulation" ], "offsets": [ [ 215, 230 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T16", "type": "Value", "text": [ "Abnormal" ], "offsets": [ [ 239, 247 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T17", "type": "Measurement", "text": [ "coagulation profile" ], "offsets": [ [ 248, 267 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T18", "type": "Condition", "text": [ "Abnormal coagulation profile" ], "offsets": [ [ 239, 267 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T19", "type": "Condition", "text": [ "Renal disorder" ], "offsets": [ [ 268, 282 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T20", "type": "Condition", "text": [ "disor", "iciency\nSickl" ], "offsets": [ [ 274, 279 ], [ 292, 305 ] ], "normalized": [] }, { "id": "NCT03631355_exc_T21", "type": "Condition", "text": [ "Sickle cell disease" ], "offsets": [ [ 300, 319 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03631355_exc_R1", "type": "Subsumes", "arg1_id": "NCT03631355_exc_T7", "arg2_id": "NCT03631355_exc_T6", "normalized": [] }, { "id": "NCT03631355_exc_R2", "type": "Has_value", "arg1_id": "NCT03631355_exc_T9", "arg2_id": "NCT03631355_exc_T8", "normalized": [] }, { "id": "NCT03631355_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03631355_exc_T14", "arg2_id": "NCT03631355_exc_T13", "normalized": [] }, { "id": "NCT03631355_exc_R5", "type": "Has_value", "arg1_id": "NCT03631355_exc_T17", "arg2_id": "NCT03631355_exc_T16", "normalized": [] } ]

[ { "id": "NCT03631355_inc_text", "type": "inclusion", "text": [ "Patients undergoing a high tibial osteotomy (HTO)\nPatients undergoing tibial tubercle osteotomy (TTO) with or without medial patello-femoral ligament (MPFL) reconstruction\n" ], "offsets": [ [ 0, 172 ] ] } ]

[ { "id": "NCT03631355_inc_T1", "type": "Procedure", "text": [ "high tibial osteotomy (HTO)" ], "offsets": [ [ 22, 49 ] ], "normalized": [] }, { "id": "NCT03631355_inc_T2", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 9, 19 ] ], "normalized": [] }, { "id": "NCT03631355_inc_T3", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 59, 69 ] ], "normalized": [] }, { "id": "NCT03631355_inc_T4", "type": "Procedure", "text": [ "tibial tubercle osteotomy (TTO)" ], "offsets": [ [ 70, 101 ] ], "normalized": [] }, { "id": "NCT03631355_inc_T5", "type": "Procedure", "text": [ "medial patello-femoral ligament (MPFL) reconstruction" ], "offsets": [ [ 118, 171 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03631355_inc_R1", "type": "Has_temporal", "arg1_id": "NCT03631355_inc_T1", "arg2_id": "NCT03631355_inc_T2", "normalized": [] }, { "id": "NCT03631355_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03631355_inc_T4", "arg2_id": "NCT03631355_inc_T3", "normalized": [] }, { "id": "NCT03631355_inc_R3", "type": "AND", "arg1_id": "NCT03631355_inc_T4", "arg2_id": "NCT03631355_inc_T5", "normalized": [] } ]

[ { "id": "NCT03637946_exc_text", "type": "exclusion", "text": [ "With severe systemic alteration;\nIn the use of antibiotics and anti-inflammatories in the last three months;\nWith periodontium with periodontal parameters different from those established in the inclusion criteria.\nIndividuals with clinical signs of parafunctional habits;\nSmoking;\nIndividuals who have performed other restorations in the last 12 months;\nPregnant women and infants;\nPeriodontal sites that presented bleeding during crevicular fluid collection or sites that prevent proper collection of clinical parameters.\n" ], "offsets": [ [ 0, 524 ] ] } ]

[ { "id": "NCT03637946_exc_T1", "type": "Condition", "text": [ "systemic alteration" ], "offsets": [ [ 12, 31 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T2", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 5, 11 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T3", "type": "Drug", "text": [ "antibiotics" ], "offsets": [ [ 47, 58 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T4", "type": "Drug", "text": [ "anti-inflammatories" ], "offsets": [ [ 63, 82 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T5", "type": "Temporal", "text": [ "in the last three months" ], "offsets": [ [ 83, 107 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T6", "type": "Scope", "text": [ "antibiotics and anti-inflammatories" ], "offsets": [ [ 47, 82 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T8", "type": "Condition", "text": [ "clinical signs of parafunctional habits" ], "offsets": [ [ 232, 271 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T9", "type": "Observation", "text": [ "Smoking" ], "offsets": [ [ 273, 280 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T10", "type": "Procedure", "text": [ "other restorations" ], "offsets": [ [ 313, 331 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T11", "type": "Temporal", "text": [ "in the last 12 months" ], "offsets": [ [ 332, 353 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T12", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 355, 363 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T13", "type": "Person", "text": [ "women" ], "offsets": [ [ 364, 369 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T14", "type": "Person", "text": [ "infants" ], "offsets": [ [ 374, 381 ] ], "normalized": [] }, { "id": "NCT03637946_exc_T15", "type": "Scope", "text": [ "Pregnant women" ], "offsets": [ [ 355, 369 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03637946_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03637946_exc_T1", "arg2_id": "NCT03637946_exc_T2", "normalized": [] }, { "id": "NCT03637946_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03637946_exc_T6", "arg2_id": "NCT03637946_exc_T5", "normalized": [] }, { "id": "NCT03637946_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03637946_exc_T10", "arg2_id": "NCT03637946_exc_T11", "normalized": [] } ]

[ { "id": "NCT03637946_inc_text", "type": "inclusion", "text": [ "Over 18 years of age; Systemically healthy; Non-smoking;\nWith good oral hygiene;\nAbsent irreversible pulpal alteration;\nWith the presence of a non-carious cervical lesion (LCNCs) that needs to be restored. This lesion should be non-carious, non-retentive, with at least 1 mm and up to 3 mm depth, should involve both enamel and dentin of vital teeth without mobility, and present hypersensitivity;\nPresence a natural tooth of the same position of the restored tooth, but in the opposite arch of the same jaw to be considered for the positive control;\nPeriodontal parameters : Depth Probing (PS), Visible Plaque Index (IPV), Gingival Index (GI) and Probing Bleed Index (SS). The normal included were: PS = 1 to 3 mm, GI = 0, IPV = score 0 e SS = score 0.\n" ], "offsets": [ [ 0, 754 ] ] } ]

[ { "id": "NCT03637946_inc_T1", "type": "Value", "text": [ "Over 18 years" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 17, 20 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T3", "type": "Condition", "text": [ "Systemically healthy" ], "offsets": [ [ 22, 42 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T4", "type": "Condition", "text": [ "Non-smoking" ], "offsets": [ [ 44, 55 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T5", "type": "Observation", "text": [ "good oral hygiene" ], "offsets": [ [ 62, 79 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T6", "type": "Condition", "text": [ "irreversible pulpal alteration" ], "offsets": [ [ 88, 118 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T7", "type": "Negation", "text": [ "Absent" ], "offsets": [ [ 81, 87 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T8", "type": "Condition", "text": [ "non-carious cervical lesion (LCNCs)" ], "offsets": [ [ 143, 178 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T9", "type": "Procedure", "text": [ "restored" ], "offsets": [ [ 196, 204 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T10", "type": "Mood", "text": [ "needs to be" ], "offsets": [ [ 184, 195 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T11", "type": "Condition", "text": [ "lesion" ], "offsets": [ [ 211, 217 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T12", "type": "Qualifier", "text": [ "non-carious" ], "offsets": [ [ 228, 239 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T13", "type": "Qualifier", "text": [ "non-retentive" ], "offsets": [ [ 241, 254 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T14", "type": "Value", "text": [ "at least 1 mm and up to 3 mm" ], "offsets": [ [ 261, 289 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T15", "type": "Measurement", "text": [ "depth" ], "offsets": [ [ 290, 295 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T16", "type": "Qualifier", "text": [ "involve both enamel and dentin" ], "offsets": [ [ 304, 334 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T17", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 380, 396 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T19", "type": "Measurement", "text": [ "Depth Probing (PS)" ], "offsets": [ [ 576, 594 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T20", "type": "Measurement", "text": [ "Visible Plaque Index (IPV)" ], "offsets": [ [ 596, 622 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T21", "type": "Measurement", "text": [ "Gingival Index (GI)" ], "offsets": [ [ 624, 643 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T22", "type": "Measurement", "text": [ "Probing Bleed Index (SS)" ], "offsets": [ [ 648, 672 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T23", "type": "Measurement", "text": [ "PS" ], "offsets": [ [ 700, 702 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T24", "type": "Value", "text": [ "= 1 to 3 mm" ], "offsets": [ [ 703, 714 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T25", "type": "Value", "text": [ "= 0" ], "offsets": [ [ 719, 722 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T26", "type": "Value", "text": [ "score 0" ], "offsets": [ [ 730, 737 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T27", "type": "Value", "text": [ "score 0" ], "offsets": [ [ 745, 752 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T28", "type": "Measurement", "text": [ "SS" ], "offsets": [ [ 740, 742 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T29", "type": "Measurement", "text": [ "IPV" ], "offsets": [ [ 724, 727 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T30", "type": "Measurement", "text": [ "GI" ], "offsets": [ [ 716, 718 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T31", "type": "Scope", "text": [ "Depth Probing (PS), Visible Plaque Index (IPV), Gingival Index (GI) and Probing Bleed Index (SS)" ], "offsets": [ [ 576, 672 ] ], "normalized": [] }, { "id": "NCT03637946_inc_T32", "type": "Scope", "text": [ "PS = 1 to 3 mm, GI = 0, IPV = score 0 e SS = score 0" ], "offsets": [ [ 700, 752 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03637946_inc_R1", "type": "Has_value", "arg1_id": "NCT03637946_inc_T2", "arg2_id": "NCT03637946_inc_T1", "normalized": [] }, { "id": "NCT03637946_inc_R2", "type": "Has_negation", "arg1_id": "NCT03637946_inc_T6", "arg2_id": "NCT03637946_inc_T7", "normalized": [] }, { "id": "NCT03637946_inc_R3", "type": "Has_mood", "arg1_id": "NCT03637946_inc_T9", "arg2_id": "NCT03637946_inc_T10", "normalized": [] }, { "id": "NCT03637946_inc_R4", "type": "Has_value", "arg1_id": "NCT03637946_inc_T15", "arg2_id": "NCT03637946_inc_T14", "normalized": [] }, { "id": "NCT03637946_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03637946_inc_T11", "arg2_id": "NCT03637946_inc_T12", "normalized": [] }, { "id": "NCT03637946_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03637946_inc_T11", "arg2_id": "NCT03637946_inc_T13", "normalized": [] }, { "id": "NCT03637946_inc_R7", "type": "AND", "arg1_id": "NCT03637946_inc_T11", "arg2_id": "NCT03637946_inc_T15", "normalized": [] }, { "id": "NCT03637946_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03637946_inc_T11", "arg2_id": "NCT03637946_inc_T16", "normalized": [] }, { "id": "NCT03637946_inc_R9", "type": "AND", "arg1_id": "NCT03637946_inc_T11", "arg2_id": "NCT03637946_inc_T17", "normalized": [] }, { "id": "NCT03637946_inc_R10", "type": "Has_value", "arg1_id": "NCT03637946_inc_T23", "arg2_id": "NCT03637946_inc_T24", "normalized": [] }, { "id": "NCT03637946_inc_R11", "type": "Has_value", "arg1_id": "NCT03637946_inc_T30", "arg2_id": "NCT03637946_inc_T25", "normalized": [] }, { "id": "NCT03637946_inc_R12", "type": "Has_value", "arg1_id": "NCT03637946_inc_T29", "arg2_id": "NCT03637946_inc_T26", "normalized": [] }, { "id": "NCT03637946_inc_R13", "type": "Has_value", "arg1_id": "NCT03637946_inc_T28", "arg2_id": "NCT03637946_inc_T27", "normalized": [] }, { "id": "NCT03637946_inc_R14", "type": "Has_scope", "arg1_id": "NCT03637946_inc_T31", "arg2_id": "NCT03637946_inc_T32", "normalized": [] } ]

[ { "id": "NCT03639519_exc_text", "type": "exclusion", "text": [ "Allergy to ascorbic acid\nAsthma\nCOPD\nAllergy to opioids\nPrevious history of chemical dependence\nPrior cardiac surgery\nKnown hyperoxaluria\nHistory of renal calculi\nHistory of allergic or hypersensitivity reaction to ascorbic acid products\nCurrently taking 1 g or more of ascorbic acid supplementation daily\n" ], "offsets": [ [ 0, 306 ] ] } ]

[ { "id": "NCT03639519_exc_T1", "type": "Drug", "text": [ "ascorbic acid" ], "offsets": [ [ 11, 24 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T2", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T3", "type": "Condition", "text": [ "Asthma" ], "offsets": [ [ 25, 31 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T4", "type": "Condition", "text": [ "COPD" ], "offsets": [ [ 32, 36 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T5", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 37, 44 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T6", "type": "Drug", "text": [ "opioids" ], "offsets": [ [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T7", "type": "Condition", "text": [ "chemical dependence" ], "offsets": [ [ 76, 95 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T8", "type": "Observation", "text": [ "history" ], "offsets": [ [ 65, 72 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T9", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 56, 64 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T10", "type": "Procedure", "text": [ "cardiac surgery" ], "offsets": [ [ 102, 117 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T11", "type": "Temporal", "text": [ "Prior" ], "offsets": [ [ 96, 101 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T12", "type": "Condition", "text": [ "hyperoxaluria" ], "offsets": [ [ 124, 137 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T13", "type": "Condition", "text": [ "renal calculi" ], "offsets": [ [ 149, 162 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T14", "type": "Observation", "text": [ "History" ], "offsets": [ [ 138, 145 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T15", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 174, 182 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T16", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 186, 202 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T17", "type": "Drug", "text": [ "ascorbic acid" ], "offsets": [ [ 215, 228 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T18", "type": "Scope", "text": [ "allergic or hypersensitivity" ], "offsets": [ [ 174, 202 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T19", "type": "Multiplier", "text": [ "1 g or more" ], "offsets": [ [ 255, 266 ] ], "normalized": [] }, { "id": "NCT03639519_exc_T20", "type": "Drug", "text": [ "ascorbic acid" ], "offsets": [ [ 270, 283 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03639519_exc_R1", "type": "AND", "arg1_id": "NCT03639519_exc_T2", "arg2_id": "NCT03639519_exc_T1", "normalized": [] }, { "id": "NCT03639519_exc_R2", "type": "AND", "arg1_id": "NCT03639519_exc_T5", "arg2_id": "NCT03639519_exc_T6", "normalized": [] }, { "id": "NCT03639519_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03639519_exc_T7", "arg2_id": "NCT03639519_exc_T8", "normalized": [] }, { "id": "NCT03639519_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03639519_exc_T7", "arg2_id": "NCT03639519_exc_T9", "normalized": [] }, { "id": "NCT03639519_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03639519_exc_T10", "arg2_id": "NCT03639519_exc_T11", "normalized": [] }, { "id": "NCT03639519_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03639519_exc_T13", "arg2_id": "NCT03639519_exc_T14", "normalized": [] }, { "id": "NCT03639519_exc_R7", "type": "AND", "arg1_id": "NCT03639519_exc_T18", "arg2_id": "NCT03639519_exc_T17", "normalized": [] }, { "id": "NCT03639519_exc_R8", "type": "Has_multiplier", "arg1_id": "NCT03639519_exc_T20", "arg2_id": "NCT03639519_exc_T19", "normalized": [] } ]

[ { "id": "NCT03639519_inc_text", "type": "inclusion", "text": [ "Elective Cardiac surgery\nAmerican Society of Anesthesiologists physical status class I-III\n" ], "offsets": [ [ 0, 91 ] ] } ]

[ { "id": "NCT03639519_inc_T1", "type": "Device", "text": [ "Elective Cardiac surgery" ], "offsets": [ [ 0, 24 ] ], "normalized": [] }, { "id": "NCT03639519_inc_T2", "type": "Measurement", "text": [ "American Society of Anesthesiologists physical status" ], "offsets": [ [ 25, 78 ] ], "normalized": [] }, { "id": "NCT03639519_inc_T3", "type": "Value", "text": [ "class I-III" ], "offsets": [ [ 79, 90 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03639519_inc_R1", "type": "Has_value", "arg1_id": "NCT03639519_inc_T2", "arg2_id": "NCT03639519_inc_T3", "normalized": [] } ]

[ { "id": "NCT03639545_exc_text", "type": "exclusion", "text": [ "diagnosed advanced heart, kidney or liver failure\nbenign prostatic hyperplasia\nprostatic carcinoma\nfrequent urinary tract infections\nnon-type 1 diabetes mellitus\n" ], "offsets": [ [ 0, 162 ] ] } ]

[ { "id": "NCT03639545_exc_T1", "type": "Condition", "text": [ "advanced heart", "failure" ], "offsets": [ [ 10, 24 ], [ 42, 49 ] ], "normalized": [] }, { "id": "NCT03639545_exc_T2", "type": "Condition", "text": [ "kidney", "failure" ], "offsets": [ [ 26, 32 ], [ 42, 49 ] ], "normalized": [] }, { "id": "NCT03639545_exc_T3", "type": "Condition", "text": [ "liver", "failure" ], "offsets": [ [ 36, 41 ], [ 42, 49 ] ], "normalized": [] }, { "id": "NCT03639545_exc_T4", "type": "Condition", "text": [ "benign prostatic hyperplasia" ], "offsets": [ [ 50, 78 ] ], "normalized": [] }, { "id": "NCT03639545_exc_T5", "type": "Condition", "text": [ "prostatic carcinoma" ], "offsets": [ [ 79, 98 ] ], "normalized": [] }, { "id": "NCT03639545_exc_T6", "type": "Multiplier", "text": [ "frequent" ], "offsets": [ [ 99, 107 ] ], "normalized": [] }, { "id": "NCT03639545_exc_T7", "type": "Condition", "text": [ "urinary tract infections" ], "offsets": [ [ 108, 132 ] ], "normalized": [] }, { "id": "NCT03639545_exc_T8", "type": "Condition", "text": [ "non-type 1 diabetes mellitus" ], "offsets": [ [ 133, 161 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03639545_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT03639545_exc_T7", "arg2_id": "NCT03639545_exc_T6", "normalized": [] } ]

[ { "id": "NCT03639545_inc_text", "type": "inclusion", "text": [ "diabetes mellitus type 1\n" ], "offsets": [ [ 0, 25 ] ] } ]

[ { "id": "NCT03639545_inc_T1", "type": "Condition", "text": [ "diabetes mellitus type 1" ], "offsets": [ [ 0, 24 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT03648021_exc_text", "type": "exclusion", "text": [ "Known hypersensitivity to paracetamol or mannitol (excipient with known effect)\nSevere hepatocellular insufficiency (ASAT or ALAT > 5N, or bilirubin > 2N)\nPharmacological intervention (administration of corticosteroids, NSAIDs or paracetamol) or physical intervention (external cooling technique) that may influence temperature in the last 6 hours.\nPregnant or breastfeeding women\nPrevious participation in this study\n" ], "offsets": [ [ 0, 418 ] ] } ]

[ { "id": "NCT03648021_exc_T1", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 6, 22 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T2", "type": "Drug", "text": [ "paracetamol" ], "offsets": [ [ 26, 37 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T3", "type": "Drug", "text": [ "mannitol" ], "offsets": [ [ 41, 49 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T5", "type": "Scope", "text": [ "paracetamol or mannitol" ], "offsets": [ [ 26, 49 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T6", "type": "Condition", "text": [ "hepatocellular insufficiency" ], "offsets": [ [ 87, 115 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T7", "type": "Measurement", "text": [ "ASAT" ], "offsets": [ [ 117, 121 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T8", "type": "Measurement", "text": [ "ALAT" ], "offsets": [ [ 125, 129 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T9", "type": "Value", "text": [ "> 5N" ], "offsets": [ [ 130, 134 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T11", "type": "Measurement", "text": [ "bilirubin" ], "offsets": [ [ 139, 148 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T12", "type": "Value", "text": [ "> 2N" ], "offsets": [ [ 149, 153 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T10", "type": "Scope", "text": [ "ASAT or ALAT > 5N, or bilirubin > 2N" ], "offsets": [ [ 117, 153 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T13", "type": "Procedure", "text": [ "Pharmacological intervention" ], "offsets": [ [ 155, 183 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T14", "type": "Drug", "text": [ "Pharmacological" ], "offsets": [ [ 155, 170 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T15", "type": "Drug", "text": [ "corticosteroids" ], "offsets": [ [ 203, 218 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T16", "type": "Drug", "text": [ "NSAIDs" ], "offsets": [ [ 220, 226 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T17", "type": "Drug", "text": [ "paracetamol" ], "offsets": [ [ 230, 241 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T18", "type": "Scope", "text": [ "corticosteroids, NSAIDs or paracetamol" ], "offsets": [ [ 203, 241 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T19", "type": "Procedure", "text": [ "physical intervention" ], "offsets": [ [ 246, 267 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T20", "type": "Procedure", "text": [ "external cooling technique" ], "offsets": [ [ 269, 295 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T21", "type": "Qualifier", "text": [ "that may influence temperature" ], "offsets": [ [ 297, 327 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T22", "type": "Temporal", "text": [ "in the last 6 hours" ], "offsets": [ [ 328, 347 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T23", "type": "Scope", "text": [ "Pharmacological intervention (administration of corticosteroids, NSAIDs or paracetamol) or physical intervention (external cooling technique)" ], "offsets": [ [ 155, 296 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T24", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 316, 327 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T25", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 349, 357 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T26", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 361, 374 ] ], "normalized": [] }, { "id": "NCT03648021_exc_T27", "type": "Person", "text": [ "women" ], "offsets": [ [ 375, 380 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03648021_exc_R1", "type": "Has_scope", "arg1_id": "NCT03648021_exc_T1", "arg2_id": "NCT03648021_exc_T5", "normalized": [] }, { "id": "NCT03648021_exc_R2", "type": "Has_value", "arg1_id": "NCT03648021_exc_T11", "arg2_id": "NCT03648021_exc_T12", "normalized": [] }, { "id": "NCT03648021_exc_R3", "type": "Has_value", "arg1_id": "NCT03648021_exc_T8", "arg2_id": "NCT03648021_exc_T9", "normalized": [] }, { "id": "NCT03648021_exc_R4", "type": "Has_value", "arg1_id": "NCT03648021_exc_T7", "arg2_id": "NCT03648021_exc_T9", "normalized": [] }, { "id": "NCT03648021_exc_R5", "type": "Subsumes", "arg1_id": "NCT03648021_exc_T6", "arg2_id": "NCT03648021_exc_T10", "normalized": [] }, { "id": "NCT03648021_exc_R7", "type": "Subsumes", "arg1_id": "NCT03648021_exc_T19", "arg2_id": "NCT03648021_exc_T20", "normalized": [] }, { "id": "NCT03648021_exc_R8", "type": "Has_scope", "arg1_id": "NCT03648021_exc_T13", "arg2_id": "NCT03648021_exc_T18", "normalized": [] }, { "id": "NCT03648021_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03648021_exc_T23", "arg2_id": "NCT03648021_exc_T21", "normalized": [] }, { "id": "NCT03648021_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03648021_exc_T23", "arg2_id": "NCT03648021_exc_T22", "normalized": [] } ]

[ { "id": "NCT03648021_inc_text", "type": "inclusion", "text": [ "18-year or older patients\nPatient hospitalized in neuro-critical care for:\nArachnoid hemorrhage\nIntra parenchymatous hematoma\nstroke\nAcute brain Severe injury\nPost-operative complication of an act of neurosurgery or programmed neuroradiology\nSedation and mechanical ventilation planned > 2 days\nMonitoring of intracranial temperature and pressure by intraparenchymal sensor (Sophysa®)\nBrain temperature > 38.5°C for more than 30 minutes\n" ], "offsets": [ [ 0, 437 ] ] } ]

[ { "id": "NCT03648021_inc_T1", "type": "Value", "text": [ "18-year or older" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T2", "type": "Person", "text": [ "old" ], "offsets": [ [ 11, 14 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T3", "type": "Visit", "text": [ "hospitalized" ], "offsets": [ [ 34, 46 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T4", "type": "Visit", "text": [ "neuro-critical care" ], "offsets": [ [ 50, 69 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T5", "type": "Condition", "text": [ "Arachnoid hemorrhage" ], "offsets": [ [ 75, 95 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T6", "type": "Qualifier", "text": [ "Intra parenchymatous" ], "offsets": [ [ 96, 116 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T7", "type": "Condition", "text": [ "hematoma" ], "offsets": [ [ 117, 125 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T8", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 126, 132 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T9", "type": "Condition", "text": [ "Acute brain Severe injury" ], "offsets": [ [ 133, 158 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T10", "type": "Condition", "text": [ "Post-operative complication" ], "offsets": [ [ 159, 186 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T11", "type": "Procedure", "text": [ "neurosurgery" ], "offsets": [ [ 200, 212 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T12", "type": "Qualifier", "text": [ "of an act of neurosurgery" ], "offsets": [ [ 187, 212 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T13", "type": "Procedure", "text": [ "neuroradiology" ], "offsets": [ [ 227, 241 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T14", "type": "Qualifier", "text": [ "act of neuro", "mmed neuroradiology\nSedat" ], "offsets": [ [ 193, 205 ], [ 222, 247 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T15", "type": "Scope", "text": [ "of an act of neurosurgery or programmed neuroradiology" ], "offsets": [ [ 187, 241 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T16", "type": "Procedure", "text": [ "mechanical ventilation" ], "offsets": [ [ 255, 277 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T17", "type": "Procedure", "text": [ "Sedation" ], "offsets": [ [ 242, 250 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T18", "type": "Temporal", "text": [ "> 2 days" ], "offsets": [ [ 286, 294 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T19", "type": "Mood", "text": [ "planned" ], "offsets": [ [ 278, 285 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T20", "type": "Scope", "text": [ "Sedation and mechanical ventilation" ], "offsets": [ [ 242, 277 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T21", "type": "Measurement", "text": [ "intracranial temperature" ], "offsets": [ [ 309, 333 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T22", "type": "Measurement", "text": [ "nial tempera", " by int" ], "offsets": [ [ 317, 329 ], [ 346, 353 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T23", "type": "Device", "text": [ "intraparenchymal sensor" ], "offsets": [ [ 350, 373 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T24", "type": "Device", "text": [ "Sophysa®" ], "offsets": [ [ 375, 383 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T25", "type": "Scope", "text": [ "intraparenchymal sensor (Sophysa®)" ], "offsets": [ [ 350, 384 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T26", "type": "Scope", "text": [ "intracranial temperature and pressure" ], "offsets": [ [ 309, 346 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T27", "type": "Measurement", "text": [ "Brain temperature" ], "offsets": [ [ 385, 402 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T28", "type": "Value", "text": [ "> 38.5°C" ], "offsets": [ [ 403, 411 ] ], "normalized": [] }, { "id": "NCT03648021_inc_T29", "type": "Temporal", "text": [ "for more than 30 minutes" ], "offsets": [ [ 412, 436 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03648021_inc_R1", "type": "Has_value", "arg1_id": "NCT03648021_inc_T2", "arg2_id": "NCT03648021_inc_T1", "normalized": [] }, { "id": "NCT03648021_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03648021_inc_T7", "arg2_id": "NCT03648021_inc_T6", "normalized": [] }, { "id": "NCT03648021_inc_R5", "type": "Has_scope", "arg1_id": "NCT03648021_inc_T10", "arg2_id": "NCT03648021_inc_T15", "normalized": [] }, { "id": "NCT03648021_inc_R6", "type": "Has_mood", "arg1_id": "NCT03648021_inc_T18", "arg2_id": "NCT03648021_inc_T19", "normalized": [] }, { "id": "NCT03648021_inc_R7", "type": "Has_temporal", "arg1_id": "NCT03648021_inc_T20", "arg2_id": "NCT03648021_inc_T18", "normalized": [] }, { "id": "NCT03648021_inc_R8", "type": "Subsumes", "arg1_id": "NCT03648021_inc_T23", "arg2_id": "NCT03648021_inc_T24", "normalized": [] }, { "id": "NCT03648021_inc_R9", "type": "Has_scope", "arg1_id": "NCT03648021_inc_T26", "arg2_id": "NCT03648021_inc_T25", "normalized": [] }, { "id": "NCT03648021_inc_R10", "type": "Has_value", "arg1_id": "NCT03648021_inc_T27", "arg2_id": "NCT03648021_inc_T28", "normalized": [] }, { "id": "NCT03648021_inc_R11", "type": "Has_temporal", "arg1_id": "NCT03648021_inc_T27", "arg2_id": "NCT03648021_inc_T29", "normalized": [] } ]

[ { "id": "NCT03663387_exc_text", "type": "exclusion", "text": [ "Uncontrolled hypertension or metabolic disease\nNeurodegenerative disorders (i.e. Parkinson disease. LBD, or FTD).\nDementia or Mild cognitive impairment at baseline\nLong life major depression. Baseline scores =16 on the 17-item Hamilton Depression Scale at baseline.\nLong-life DSM-IV axis 1 disorders.\nMental retardation.\nSubstance abuse.\nConcurrent medication limiting validity of neuropsychological tests or imaging.\nAnti-depressants with anti-cholinergic properties\nMonoamine oxidase inhibitors (MAOi)\nRegular use of narcotic analgesics (>2 doses per week).\nUse of neuroleptics\nUse of anti-dementia medications (Aricept, Exelon, Razadyne) and memantine (Namenda)) or anti-Parkinsonian medications (Sinemet, amantadine, bromocriptine, pergolide, selegeline).\nIndividuals taking over the counter memory enhancing or protecting medications (e.g. ginkgo biloba, vitamins) are not excluded.\nImplanted medical devices that are incompatible with MRI imaging.\nRadiation exposures exceeding annual Rad Worker limits.\nHeart failure stage D as defined by American Heart Association (7).\nChronic kidney disease in stages = 4, as defined per National Kidney Foundation (8).\nBrain tumor and other neoplastic disorders outside the brain where disease itself or its treatment (radiation, chemotherapy) is likely to affect brain structure or function.\nStroke when meeting criteria for total anterior, partial anterior or posterior circulation infarct according to the Oxford Community Stroke Project classification. Patients with clinically silent of lacunar strokes and transient ischemic attacks will not be excluded.\nSignificant head trauma.\nHydrocephalus.\nHostility or refusal to cooperate\n" ], "offsets": [ [ 0, 1679 ] ] } ]

[ { "id": "NCT03663387_exc_T1", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 13, 25 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T2", "type": "Condition", "text": [ "metabolic disease" ], "offsets": [ [ 29, 46 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T3", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T4", "type": "Scope", "text": [ "hypertension or metabolic disease" ], "offsets": [ [ 13, 46 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T5", "type": "Condition", "text": [ "Neurodegenerative disorders" ], "offsets": [ [ 47, 74 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T6", "type": "Condition", "text": [ "Parkinson disease" ], "offsets": [ [ 81, 98 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T7", "type": "Condition", "text": [ "LBD" ], "offsets": [ [ 100, 103 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T8", "type": "Condition", "text": [ "FTD" ], "offsets": [ [ 108, 111 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T9", "type": "Scope", "text": [ "Parkinson disease. LBD, or FTD" ], "offsets": [ [ 81, 111 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T10", "type": "Condition", "text": [ "Dementia" ], "offsets": [ [ 114, 122 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T11", "type": "Condition", "text": [ "Mild cognitive impairment" ], "offsets": [ [ 126, 151 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T12", "type": "Measurement", "text": [ "cognitive impairment" ], "offsets": [ [ 131, 151 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T13", "type": "Value", "text": [ "Mild" ], "offsets": [ [ 126, 130 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T14", "type": "Temporal", "text": [ "at baseline" ], "offsets": [ [ 152, 163 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T15", "type": "Scope", "text": [ "Dementia or Mild cognitive impairment" ], "offsets": [ [ 114, 151 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T16", "type": "Condition", "text": [ "Long life major depression" ], "offsets": [ [ 164, 190 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T17", "type": "Measurement", "text": [ "Baseline scores" ], "offsets": [ [ 192, 207 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T18", "type": "Value", "text": [ "=16" ], "offsets": [ [ 208, 211 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T19", "type": "Measurement", "text": [ "17-item Hamilton Depression Scale" ], "offsets": [ [ 219, 252 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T20", "type": "Temporal", "text": [ "at baseline" ], "offsets": [ [ 253, 264 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T21", "type": "Reference_point", "text": [ "baseline" ], "offsets": [ [ 256, 264 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T22", "type": "Condition", "text": [ "Long-life DSM-IV axis 1 disorders" ], "offsets": [ [ 266, 299 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T23", "type": "Condition", "text": [ "Mental retardation" ], "offsets": [ [ 301, 319 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T24", "type": "Condition", "text": [ "Substance abuse" ], "offsets": [ [ 321, 336 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T25", "type": "Temporal", "text": [ "Concurrent" ], "offsets": [ [ 338, 348 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T26", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 349, 359 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T27", "type": "Qualifier", "text": [ "limiting validity of neuropsychological tests" ], "offsets": [ [ 360, 405 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T28", "type": "Qualifier", "text": [ "g validity of neurop", ".\nAnti-" ], "offsets": [ [ 367, 387 ], [ 416, 423 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T29", "type": "Scope", "text": [ "limiting validity of neuropsychological tests or imaging" ], "offsets": [ [ 360, 416 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T30", "type": "Drug", "text": [ "Anti-depressants" ], "offsets": [ [ 418, 434 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T31", "type": "Qualifier", "text": [ "anti-cholinergic properties" ], "offsets": [ [ 440, 467 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T32", "type": "Drug", "text": [ "anti-cholinergic" ], "offsets": [ [ 440, 456 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T33", "type": "Drug", "text": [ "Monoamine oxidase inhibitors (MAOi)" ], "offsets": [ [ 468, 503 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T34", "type": "Drug", "text": [ "narcotic analgesics" ], "offsets": [ [ 519, 538 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T35", "type": "Multiplier", "text": [ ">2 doses per week" ], "offsets": [ [ 540, 557 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T36", "type": "Multiplier", "text": [ "Regular use" ], "offsets": [ [ 504, 515 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T37", "type": "Drug", "text": [ "neuroleptics" ], "offsets": [ [ 567, 579 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T38", "type": "Drug", "text": [ "anti-dementia medications" ], "offsets": [ [ 587, 612 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T39", "type": "Drug", "text": [ "Aricept" ], "offsets": [ [ 614, 621 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T40", "type": "Drug", "text": [ "Exelon" ], "offsets": [ [ 623, 629 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T41", "type": "Drug", "text": [ "Razadyne" ], "offsets": [ [ 631, 639 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T42", "type": "Scope", "text": [ "Aricept, Exelon, Razadyne" ], "offsets": [ [ 614, 639 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T43", "type": "Drug", "text": [ "memantine" ], "offsets": [ [ 645, 654 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T44", "type": "Drug", "text": [ "Namenda" ], "offsets": [ [ 656, 663 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T45", "type": "Drug", "text": [ "anti-Parkinsonian medications" ], "offsets": [ [ 669, 698 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T46", "type": "Drug", "text": [ "Sinemet" ], "offsets": [ [ 700, 707 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T47", "type": "Drug", "text": [ "amantadine" ], "offsets": [ [ 709, 719 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T48", "type": "Drug", "text": [ "bromocriptine" ], "offsets": [ [ 721, 734 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T49", "type": "Drug", "text": [ "pergolide" ], "offsets": [ [ 736, 745 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T50", "type": "Drug", "text": [ "selegeline" ], "offsets": [ [ 747, 757 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T51", "type": "Scope", "text": [ "Sinemet, amantadine, bromocriptine, pergolide, selegeline" ], "offsets": [ [ 700, 757 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T52", "type": "Drug", "text": [ "ter memory enhancing or protectin", "e.g. ginkgo" ], "offsets": [ [ 792, 825 ], [ 840, 851 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T53", "type": "Drug", "text": [ "ter memory enhancing or", "dications (e.g. ginkgo" ], "offsets": [ [ 792, 815 ], [ 829, 851 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T54", "type": "Drug", "text": [ "ginkgo biloba" ], "offsets": [ [ 845, 858 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T55", "type": "Drug", "text": [ "vitamins" ], "offsets": [ [ 860, 868 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T56", "type": "Scope", "text": [ "ginkgo biloba, vitamins" ], "offsets": [ [ 845, 868 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T57", "type": "Scope", "text": [ "over the counter memory enhancing or protecting medications" ], "offsets": [ [ 779, 838 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T59", "type": "Device", "text": [ "medical devices" ], "offsets": [ [ 898, 913 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T60", "type": "Procedure", "text": [ "MRI imaging" ], "offsets": [ [ 941, 952 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T61", "type": "Qualifier", "text": [ "incompatible with MRI imaging" ], "offsets": [ [ 923, 952 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T62", "type": "Measurement", "text": [ "Radiation exposures" ], "offsets": [ [ 954, 973 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T63", "type": "Value", "text": [ "exceeding annual Rad Worker limits" ], "offsets": [ [ 974, 1008 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T64", "type": "Condition", "text": [ "Heart failure" ], "offsets": [ [ 1010, 1023 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T65", "type": "Measurement", "text": [ "stage" ], "offsets": [ [ 1024, 1029 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T66", "type": "Value", "text": [ "D" ], "offsets": [ [ 1030, 1031 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T68", "type": "Qualifier", "text": [ "American Heart Association" ], "offsets": [ [ 1046, 1072 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T69", "type": "Condition", "text": [ "Chronic kidney disease" ], "offsets": [ [ 1078, 1100 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T70", "type": "Measurement", "text": [ "stages" ], "offsets": [ [ 1104, 1110 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T71", "type": "Value", "text": [ "= 4" ], "offsets": [ [ 1111, 1114 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T72", "type": "Qualifier", "text": [ "National Kidney Foundation" ], "offsets": [ [ 1131, 1157 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T67", "type": "Condition", "text": [ "Brain tumor" ], "offsets": [ [ 1163, 1174 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T73", "type": "Condition", "text": [ "neoplastic disorders" ], "offsets": [ [ 1185, 1205 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T74", "type": "Qualifier", "text": [ "outside the brain" ], "offsets": [ [ 1206, 1223 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T75", "type": "Qualifier", "text": [ "likely to affect brain structure" ], "offsets": [ [ 1291, 1323 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T76", "type": "Qualifier", "text": [ "rain structure or func", "hen meet" ], "offsets": [ [ 1309, 1331 ], [ 1345, 1353 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T77", "type": "Procedure", "text": [ "radiation" ], "offsets": [ [ 1263, 1272 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T78", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 1274, 1286 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T79", "type": "Scope", "text": [ "Brain tumor and other neoplastic disorders outside the brain where disease itself or its treatment (radiation, chemotherapy)" ], "offsets": [ [ 1163, 1287 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T80", "type": "Scope", "text": [ "ikely to affect brain structure or function" ], "offsets": [ [ 1292, 1335 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T81", "type": "Condition", "text": [ "Stroke" ], "offsets": [ [ 1337, 1343 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T82", "type": "Condition", "text": [ "circulation infarct" ], "offsets": [ [ 1416, 1435 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T83", "type": "Qualifier", "text": [ "posterior" ], "offsets": [ [ 1406, 1415 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T84", "type": "Qualifier", "text": [ "total anterior" ], "offsets": [ [ 1370, 1384 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T85", "type": "Qualifier", "text": [ "partial anterior" ], "offsets": [ [ 1386, 1402 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T86", "type": "Scope", "text": [ "total anterior, partial anterior or posterior" ], "offsets": [ [ 1370, 1415 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T87", "type": "Measurement", "text": [ "Oxford Community Stroke Project classification" ], "offsets": [ [ 1453, 1499 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T89", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1605, 1616 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T90", "type": "Condition", "text": [ "head trauma" ], "offsets": [ [ 1617, 1628 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T91", "type": "Condition", "text": [ "Hydrocephalus" ], "offsets": [ [ 1630, 1643 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T92", "type": "Observation", "text": [ "refusal to cooperate" ], "offsets": [ [ 1658, 1678 ] ], "normalized": [] }, { "id": "NCT03663387_exc_T93", "type": "Observation", "text": [ "Hostility" ], "offsets": [ [ 1645, 1654 ] ], "normalized": [] } ]

[]

[]

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[ { "id": "NCT03663387_inc_text", "type": "inclusion", "text": [ "Male and female subjects between 40-85 years old will be enrolled. Younger subjects are not included as the risk for brain amyloid lesions is too low\nAll subjects will speak English as their first language or demonstrate proficiency in English (defined as reaching a scaled score of > 11 on the WAIS vocabulary test).\nAll subjects will have normal cognition at baseline: a Clinical Dementia Rating CDR=0, Global Deterioration Scale GDS<2.\nAll subjects will be in good general health and able to participate in the LP and imaging exams. This determination is made by the study neurologist and reviewed at a consensus meeting for each subject.\n" ], "offsets": [ [ 0, 642 ] ] } ]

[ { "id": "NCT03663387_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T2", "type": "Person", "text": [ "female" ], "offsets": [ [ 9, 15 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T3", "type": "Value", "text": [ "between 40-85 years" ], "offsets": [ [ 25, 44 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T4", "type": "Person", "text": [ "old" ], "offsets": [ [ 45, 48 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T6", "type": "Observation", "text": [ "speak English" ], "offsets": [ [ 168, 181 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T7", "type": "Qualifier", "text": [ "first language" ], "offsets": [ [ 191, 205 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T8", "type": "Observation", "text": [ "proficiency in English" ], "offsets": [ [ 221, 243 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T9", "type": "Measurement", "text": [ "WAIS vocabulary test" ], "offsets": [ [ 295, 315 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T10", "type": "Value", "text": [ "> 11" ], "offsets": [ [ 283, 287 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T11", "type": "Scope", "text": [ "> 11 on the WAIS vocabulary test" ], "offsets": [ [ 283, 315 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T12", "type": "Condition", "text": [ "normal cognition" ], "offsets": [ [ 341, 357 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T13", "type": "Temporal", "text": [ "at baseline" ], "offsets": [ [ 358, 369 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T14", "type": "Measurement", "text": [ "Clinical Dementia Rating CDR" ], "offsets": [ [ 373, 401 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T15", "type": "Value", "text": [ "=0" ], "offsets": [ [ 401, 403 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T16", "type": "Measurement", "text": [ "Global Deterioration Scale GDS" ], "offsets": [ [ 405, 435 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T17", "type": "Value", "text": [ "<2" ], "offsets": [ [ 435, 437 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T18", "type": "Condition", "text": [ "good general health" ], "offsets": [ [ 463, 482 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T19", "type": "Observation", "text": [ "able to participate" ], "offsets": [ [ 487, 506 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T20", "type": "Procedure", "text": [ "imaging exams" ], "offsets": [ [ 521, 534 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T21", "type": "Procedure", "text": [ "LP" ], "offsets": [ [ 514, 516 ] ], "normalized": [] }, { "id": "NCT03663387_inc_T22", "type": "Scope", "text": [ "LP and imaging exams" ], "offsets": [ [ 514, 534 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03663387_inc_R1", "type": "Has_value", "arg1_id": "NCT03663387_inc_T4", "arg2_id": "NCT03663387_inc_T3", "normalized": [] }, { "id": "NCT03663387_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03663387_inc_T6", "arg2_id": "NCT03663387_inc_T7", "normalized": [] }, { "id": "NCT03663387_inc_R3", "type": "Has_value", "arg1_id": "NCT03663387_inc_T9", "arg2_id": "NCT03663387_inc_T10", "normalized": [] }, { "id": "NCT03663387_inc_R4", "type": "Subsumes", "arg1_id": "NCT03663387_inc_T8", "arg2_id": "NCT03663387_inc_T11", "normalized": [] }, { "id": "NCT03663387_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03663387_inc_T12", "arg2_id": "NCT03663387_inc_T13", "normalized": [] }, { "id": "NCT03663387_inc_R6", "type": "Has_value", "arg1_id": "NCT03663387_inc_T14", "arg2_id": "NCT03663387_inc_T15", "normalized": [] }, { "id": "NCT03663387_inc_R7", "type": "Has_value", "arg1_id": "NCT03663387_inc_T16", "arg2_id": "NCT03663387_inc_T17", "normalized": [] }, { "id": "NCT03663387_inc_R8", "type": "AND", "arg1_id": "NCT03663387_inc_T12", "arg2_id": "NCT03663387_inc_T14", "normalized": [] }, { "id": "NCT03663387_inc_R9", "type": "AND", "arg1_id": "NCT03663387_inc_T12", "arg2_id": "NCT03663387_inc_T16", "normalized": [] }, { "id": "NCT03663387_inc_R10", "type": "Has_scope", "arg1_id": "NCT03663387_inc_T19", "arg2_id": "NCT03663387_inc_T22", "normalized": [] } ]