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8978347

Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.

vacA encodes the vacuolating cytotoxin of Helicobacter pylori and exhibits marked variation in signal sequence and midgene coding regions. The implications for gastroduodenal pathology are unknown. The aim of this study was to define the association of vacA genotype with gastric inflammation and injury, in vitro cytotoxin activity, and peptic ulceration.

Adult,Aged,Aged, 80 and over,Anti-Inflammatory Agents, Non-Steroidal,Aspirin,Atrophy,Bacterial Proteins,Cytotoxins,Duodenal Ulcer,Gastric Mucosa,Genes, Bacterial,Genotype,Helicobacter pylori,Humans,Immunity, Cellular,Lymphocytes,Middle Aged,Neutrophils,Prospective Studies,Stomach Ulcer

1346517,1677696,1732141,1734052,1925309,2307514,2586553,2753403,2891957,2913034,7473834,7615729,7629077,7650174,7657096,7699060,7743510,7790461,7797114,7908671,8144644,8163943,8307041,8516329,8547526,8558837,8825091

8978348

The toxin of diarrheic shellfish poisoning, okadaic acid, increases intestinal epithelial paracellular permeability.

Diarrhea associated with shellfish poisoning is poorly understood. The responsible toxin, dinophysistoxin 1, has been identified as okadaic acid, a potent phosphatase inhibitor, but its effects on intestinal epithelia have not been examined. The aim of this study was to investigate the effect of okadaic acid on intestinal epithelial function, both Cl- secretion and barrier function.

Cell Membrane Permeability,Cells, Cultured,Electric Impedance,Enzyme Inhibitors,Gap Junctions,Humans,Intestinal Mucosa,Marine Toxins,Membrane Glycoproteins,Okadaic Acid,Phosphorylation,Pyrans

599551,1318034,1328303,1645745,1709169,1872400,1991832,2547193,2562908,2851982,2897128,3035385,3058723,3141478,3196474,3392684,3564062,3934178,6214623,6315773,6685995,7523419,8238310

8978349

Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation.

The pathogenesis of nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal damage remains poorly understood. The aim of this study was to examine the relative importance of the three suggested components of the pathogenesis of NSAID enteropathy, namely, epithelial permeability, enteric bacterial numbers, and enterohepatic recirculation, using an NSAID derivative (nitrofenac) that does not cause small intestinal damage.

Animals,Anti-Inflammatory Agents, Non-Steroidal,Cell Membrane Permeability,Colony Count, Microbial,Diclofenac,Enterohepatic Circulation,Intestinal Mucosa,Male,Rats,Rats, Wistar

331401,548543,1175882,1427372,1651657,1675786,1906938,1987878,2116253,2613835,2630303,2691345,3384981,3609658,5423889,5495986,5765565,6464502,6778761,7610343,7610982,7714752,7840196,7906675,8015340,8020659,8088345,8131699,8141297,8214062,8444070,8454631,8500743,8513438

8978350

Glutamine depletion and increased gut permeability in nonanorectic, non-weight-losing tumor-bearing rats.

Glutamine is an essential amino acid for rapidly dividing cells such as enterocytes. The progress of cancer is associated with a decrease of arterial and muscle glutamine concentrations. The aim of this study was to test whether increasing tumor loads affect gut intracellular glutamine handling, protein turnover, and gut absorptive and barrier function.

Amino Acids,Animals,Atrophy,Carcinogens,Cell Membrane Permeability,Female,Glutamine,Intestinal Absorption,Intestinal Mucosa,Methylcholanthrene,Neoplasms, Experimental,Rats

91841,350276,1200644,1317756,1347032,1488158,1892702,1899558,2058669,2119455,2119460,2495775,2868989,2881698,2910253,3124596,3140766,3142442,3292798,3336272,3949090,4032170,5022383,5789918,6576199,6809323,6882397,7226107,7350142,7485512,7625177,7726676,7729650,7783655,7828166,7840186,7866514,7902848,7933432,7933435,7940191,8044600,8098788,8099476,8106581,8257221,8368392,8427775,8476049,8680582,8680601,8779972

8978351

Peptide YY inhibition of rat gastric enterochromaffin-like cell function.

The cellular target for peptide YY (PYY) inhibition of gastric acid secretion is unknown. The aim of this study was to determine whether PYY inhibits histamine release from isolated enterochromaffin-like (ECL) cells by stimulation of a selective Y receptor.

Animals,Calcium,Cells, Cultured,Gastrins,Gastrointestinal Hormones,Histamine Release,Peptide YY,Peptides,Pertussis Toxin,Rats,Receptors, Gastrointestinal Hormone,Somatostatin,Virulence Factors, Bordetella

1317848,1321422,1335068,1443144,1672470,1704288,1971469,2050189,2070700,2083801,2159475,2413769,2868024,2888314,2905061,3360265,3557015,3770364,3838121,3838162,3839479,6892950,6956876,6957876,7479331,7485594,7523214,7524350,7535269,7592911,7611415,7687574,7716060,7851489,7913982,7915853,7965758,8093875,8098766,8101697,8134313,8388641,8514036,8530415,8550622,8772509,8964409,9001438

8978352

Effect of transforming growth factor alpha and interleukin 8 on somatostatin release from canine fundic D cells.

Helicobacter pylori infection in patients who have peptic ulcer disease is associated with altered regulation of gastric secretion, hypergastrinemia, and diminished somatostatin expression in gastric mucosa. Tumor necrosis factor (TNF)-alpha and interleukin (IL)-8 are the predominant cytokines produced in the gastric mucosa of patients with H. pylori infection. The aim of this study was to examine whether IL-8 and TNF-alpha could regulate somatostatin release from isolated canine gastric D cells.

Animals,Cells, Cultured,Dogs,Gastric Fundus,Interleukin-8,Somatostatin,Transforming Growth Factor alpha

434940,1103152,1329495,1346517,1357347,1371090,1568643,1612474,1684921,1762032,1883953,1968059,1979715,2036963,2163305,2177854,2334464,2542010,2564680,2784674,2859810,2874559,2886055,2894935,2999289,3486936,3500186,3511389,3926894,3932039,3933111,6103539,7520939,7657096,7806065,7907136,7909635,7916715,8037707,8097889,8098910,8214065,8409424,8418474,8454862

8978353

Development of c-Kit-positive cells and the onset of electrical rhythmicity in murine small intestine.

Little is known about the development of interstitial cells (ICs), yet these cells are important in electrical rhythmicity and neurotransmission in the gastrointestinal tract. This study characterized the development of ICs and the onset of electrical rhythmicity in the murine intestine.

Animals,Biomarkers,Female,Intestine, Small,Membrane Potentials,Mice,Mice, Inbred BALB C,Muscle, Smooth,Proto-Oncogene Proteins c-kit

921492,1271086,1283735,1562182,1607600,1699718,2476167,2992805,3564893,3953815,3985365,4906488,7530333,7530502,7536655,7538451,7542218,7824273,7853230,8056618,8114938,8114939,8114940,8238347,8572188,8581930,8631250,8690216,13626839

8978354

The mechanism of altered neural function in a rat model of acute colitis.

Distal colitis induced in rats by trinitrobenzene sulfonic acid (TNBS) causes a suppression of [3H]noradrenaline release from the myenteric plexus, of inflamed distal colon, as well as in noninflamed regions of colon and ileum. The aim of this study was to explore the mechanisms underlying these neural changes in TNBS colitis.

Acute Disease,Administration, Topical,Adrenergic Fibers,Animals,Anti-Inflammatory Agents,Budesonide,Colitis,Colon,Glucocorticoids,Interleukin 1 Receptor Antagonist Protein,Male,Mice,Norepinephrine,Potassium Chloride,Pregnenediones,Premedication,Rats,Rats, Nude,Rats, Sprague-Dawley,Receptors, Interleukin-1,Sialoglycoproteins,Trinitrobenzenesulfonic Acid

422189,1325127,1378803,1646141,1847118,2166442,2169393,2535830,2545504,2692462,2914642,3653643,5840032,6161074,6946713,7631788,7657099,7926489,8076755,8430802,8500728,13090060

8978355

Phenotypes of B and T cells in human intestinal and mesenteric lymph.

Cells in lymph draining the human gut have not been characterized previously. The aim of this study was to phenotype B and T cells present in microlymphatics of Peyer's pathces and in mesenteric lymph.

Adult,B-Lymphocyte Subsets,Flow Cytometry,Humans,Immunologic Surveillance,Immunophenotyping,Integrins,L-Selectin,Lymph,Lymphatic System,Mesentery,Middle Aged,Peyer's Patches,T-Lymphocyte Subsets

41638,62631,1442306,1516614,1627249,2141568,2182762,2202045,2242419,2415631,2450831,2481336,2564416,3470804,3498635,3517160,3701119,4213445,4934147,7507411,7511642,7533081,7542550,7591989,7695886,7705420,7917107,8194701,8235448,8258351,8347302,8388798,8466633,8552990,8600538,8621908