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The severity of the haemorrhagic diathesis prompted us to describe the case in order to draw the attention of medical personnel to the dangerous potentiation effects of different drugs administered with vitamin K antagonists.
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Approximately 1 year after symptom onset he developed mild seropositive oculobulbar myasthenia gravis, which spontaneously remitted after 5 months.
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Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.
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This potentially fatal complication is difficult to treat and should be widely known.
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Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.
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The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.
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She had, in July 1977, severe claudication of the lower extremities.
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Suppression of endogenous cortisol production and replacement with more physiologic concentrations of glucocorticoid were associated with clinical improvement and appeared to contribute to her recovery.
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She developed a wide complex dysrhythmia which responded to sodium bicarbonate therapy.
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A senile patient showed a dramatic recovery from medication-resistant depression after non-convulsive electroshock therapy (nc-EST), with a lasting change in response to trazodone, which mainly acts as a serotonin re-uptake inhibitor.
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Verapamil, a class IV anti-arrhythmic drug that blocks voltage-dependent calcium channels in cardiac and smooth muscle, also has effects on presynaptic and postsynaptic voltage-dependent calcium channels at the neuromuscular junction.
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Thyroid dysfunction has been reported in patients with malignant disease treated with recombinant alpha interferon.
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MEASUREMENTS AND MAIN RESULTS: Extensive noncardiogenic pulmonary edema.
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We review the literature on previously reported cases of cutaneous necrosis after injection of standard interferon alfa or pegylated interferon alfa-2b and discuss the different pathophysiologic mechanisms that might be involved.
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Hepatic reactions to cyclofenil.
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Bilateral subthalamic nucleus stimulation results in reversal of alopecia in Parkinson's disease.
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These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis.
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We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.
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We describe such a case who responded to chemotherapy and not to low doses of corticosteroids.
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This "fibroelastic form" would represent the acute or subacute phase of constriction.
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Disseminated toxoplasmosis with pulmonary involvement after heart transplantation.
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The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.
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Color Doppler imaging of the thyroid gland in a fetus with congenital goiter: a case report.
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The infiltrates did not affect the refractive outcome of the surgery.
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We report the outcomes of two pregnancies with first trimester disulfiram exposure.
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Seven months after undergoing a syngeneic PBSC transplant for AML, our patient presented with fever without localizing signs.
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In conclusion that immunocompromised patients with impaired cellular and humoral immunity are at risk for the development of opportunistic infections and hematologic abnormalities.
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We report three patients with transformed migraine, previously refractory to a wide variety of traditional preventive pharmacologic and nonpharmacologic interventions.
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Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma.
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We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.
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However, we cannot exclude a primitive effect of erythropoietin on the endothelium or on the platelets.
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No flares were observed either in clinical symptoms or in laboratory examinations during pregnancy or after delivery.
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BACKGROUND: 5-fluorouracil (5-FU) targets rapidly dividing cancer cell populations.
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Tetracycline and benign intracranial hypertension: report of five cases.
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He recovered completely after lamivudine therapy was started, but this severe adverse event could have been prevented if screening for HBV and pre-emptive therapy with lamivudine would have been started prior to infliximab.
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Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.
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We describe a heart transplant patient who presented with a large right-sided chest wall mass as a manifestation of disseminated histoplasmosis.
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Five of 157 (3.2%) patients with small cell carcinoma were clinically diagnosed as having the ectopic ACTH syndrome.
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Six days after starting acyclovir she exhibited signs of lithium toxicity.
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Two of the five patients who worsened motorically also developed encephalopathy during risperidone treatment; the encephalopathy resolved when the patients were switched to clozapine treatment.
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We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.
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The signs and symptoms were similar to those seen with systemic use of the drug for other ailments.
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Pleural and broncheoalveolar fluid analyses (BAL) showed eosinophils.
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We identified NAT2*6/*7 in one patient, and NAT2*6/*5 in the other, suggesting that both were slow acetylator phenotypes.
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OBSERVATIONS: In both patients, at the time of the visual disturbances, macular edema was clearly observed by OCT.
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The association between choroidal neovascularization (CNV) and retinal vein occlusive disease is uncommon.
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This is not a controlled study but an anecdotal experience that resulted in improved outcomes in a patient with multiple allergies, including iron dextran.
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Physicians should be aware of the risk of severe AIHA in CLL patients with a history of AIHA or positivation of the DAT during previous fludarabine administration, or in case of secondary fixation of complement to the red cell membrane occurring during fludarabine treatment.
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We report a 34-year-old man with a history of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), treated with different chemotherapy regimens, including anthracyclines and Rituximab.
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The areas under the curve for theophylline alone and theophylline with zafirlukast were 29.3 and 197 (mg x h)/L, respectively.
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All patients except two had new recurrences within the observation time.
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Corticosteroids were found to worsen and prolong the course of disease.
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On hospital day 47 (day 45 of nesiritide therapy), the patient received an 18-fold overdose of nesiritide, with no hemodynamic, cardiac, or renal sequelae.
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Resting motor threshold (RMT), active motor threshold (AMT), MEP size, intracortical inhibition (ICI) and intracortical facilitation (ICF) were tested during and after suspension of hormonal therapy.
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METHODOLOGY: A case series of nine patients with lead poisoning who required inpatient management, identified through a Clinical Toxicology Service.
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INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.
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Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil.
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Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension.
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Thirty-four thousand one hundred eighty-one patients with computerized ECGs were screened for QTc prolongation.
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METHODS: A 54-year-old healthy male underwent uneventful bilateral LASIK for the correction of myopia and astigmatism (-5.75 -3.00 x 20 degrees right eye, -5.50 -3.00 x 170 degrees left eye).
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We describe a 73-year-old woman who developed serious systemic vasculitis with associated thrombocytopenia in the course of treatment with cladribine.
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Adult patients with transfusional hemosiderosis were given ascorbic acid and treated with the iron chelator, desferrioxamine B.
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A recent consensus suggested that endoscopic injection of tissue glue for gastric variceal obliteration (GVO) should be the first choice for treatment of acute gastric variceal bleeding.
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Within the past 10 years, 47 cases of BC infection have been published.
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Peripheral neuropathy associated with capecitabine.
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Vincristine induced cranial polyneuropathy.
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The more common grade 3 or 4 adverse effects of sunitinib include hypertension, fatigue, hand-foot syndrome, elevated lipase and lymphopenia.
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OBJECTIVE: We report two cases of lost seizure control associated with the generic substitution of carbamazepine, review pertinent literature, and discuss the impact of this substitution on patient care.
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We describe three patients who had been exposed to various solvents for more than 20 years (25, 34, and 46 years).
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Diclofenac and increasing doses of opioids did not give adequate pain relief and led to opioid toxicity.
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We report here a 34-year-old woman with complicated severe opportunistic pulmonary infection, who was treated with the newly developed antibiotics quinupristin/dalfopristin (QPR/DPR) and voriconazole.
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We report a patient with recurrent, increasingly severe episodes of PPE, ultimately complicated by a severe bullous eruption, following successive cycles of high-dose cytarabine for the treatment of acute lymphoblastic leukaemia.
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After the moxifloxacin was stopped, the corrected QT interval normalized and a permanent cardiac pacemaker was implanted.
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An effective schema for the treatment of tardive dyskinesia includes avoiding antiparkinsonian medication and prescribing deanol, an acetylcholine precursor, while continuing or increasing phenothiazine dosages.
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Bacteriological culture of the removed graft identified Escherichia coli and Peptostreptococcus.
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He underwent liver biopsy and biochemical screening to evaluate whether he would benefit from interferon (IFN) treatment.
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A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years (phenobarbitone therapy); 1.5 years later valproate (2-propylpentanoic acid, VPA) was added to the therapy.
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The challenge case showed eosinophilia with 1.2 10(9)/l (z = 1.79, p = 0.04) being followed by normalization despite clozapine continuation, whereas the maximum value reached 2.1 10(9)/l in the single episode case, with consecutive normalization and uninterrupted treatment.
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Despite a response of the meningeal tumor the patient developed in the third week of MTX treatment a progressive visual loss and loss of consciousness which worsened during subsequent Ara-C treatment and led to death within 3 weeks.
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However, peripheral and cerebral embolism occurred.
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To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.
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Further research and better communication among health care professionals are needed to determine if prophylaxis can reduce adverse ocular events.
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Chronic fentanyl application induces adrenocortical insufficiency.
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Clinical and histological information on three additional patients seen at two institutions (Rochester Methodist Hospital, Rochester, MN, and Fairview-University Medical Center, Minneapolis, MN) by the authors were also compiled.
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EBV-associated post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication following solid organ transplantation and hematopoietic stem cell transplantation (HSCT) using bone marrow or peripheral blood as stem cell sources, but rarely reported in umbilical cord blood transplantation (UCBT).
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The tyrosine kinase activity and its effects represent a potential pharmacologic target of tyrosine kinase inhibitors, such as imatinib.
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METHODS: A retrospective case series and chart review of all patients treated in our tertiary care private practice for late-onset interface inflammation associated with elevated intraocular pressure.
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As a result of this and other evidence, the investigation of the adoptive parents was terminated.
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A 57-year-old male, known admitted for below knee amputation, with infection and gangrene of the left foot.
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An 18-year-old male patient was under treatment with infliximab at a dose of 5 mg/kg at Weeks 0, 2 and 6 for refractory Crohn's disease.
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A case report.
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Dental management for head and neck cancer patients undergoing radiation therapy: comprehensive patient based planning--a case report.
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This is our first well-documented observation of persistent cutaneous anesthesia caused by a spider bite.
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We report a case of a 65-year-old man suffering from a dilatative cardiomyopathy and concomitant MRSA infection who received a biventricular assist device.
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Antipsychotic medications have been associated with significant cardiovascular adverse effects and instances of sudden cardiac death.
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A 54-year-old female was admitted to our hospital for gingival bleeding and was diagnosed as acute promyelocytic leukemia (APL).
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MI related to the use of activated and non-activated PCCs predominantly affects young patients who often have no preceding history of, or risk factors for, MI and tends to be associated with large cumulative doses of concentrate.
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Differential diagnosis and theories regarding the development of these neuroleptic-induced disorders are reviewed.
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Atypical haemolytic uraemic syndrome as a complication of induction chemotherapy for acute lymphoblastic leukaemia.
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The patient improved with vancomycin and high-dose ampicillin therapy.
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