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184790 | Low energy solution for drinking water production by a revival of electrodialysis systems | The REvivED water project will establish electrodialysis (ED) as the new standard providing a source of safe, affordable, and cost-competitive drinking water, using less than half the energy required by state-of-the-art Reverse Osmosis (RO) plants.
The innovations of the project constitute a technology platform with a very wide field of potential applications. All components and systems have reached at least TRL4 and will be further developed reaching at least TRL7. The main focus of the project will be on the following applications:
1. A simplified ED system that can be used for brackish water desalination (8 pilots in developing countries) or for tap-water softening (2 pilots in Germany and the Netherlands).
2. A multistage ED system for industrial-scale seawater desalination, which will be demonstrated to reach energy consumption as low as 1.5 kWh/m3 (1 pilot in the Netherlands)
3. Combinations of the multistage ED system with the latest salinity gradient power systems (Reverse ElectroDialysis - RED), which can further reduce energy consumption for seawater desalination to the region of 1 kWh/m3 (1 pilot in the Netherlands)
4. The versatile nature of the developed innovations will be demonstrated by testing their combinations with Reverse Osmosis (RO) systems (1 pilot in Spain). This will allow initial market introduction, without the need to replace the extensive RO infrastructure.
The pilot systems in developing countries will be located in critical areas where the project partner PHAESUN has local offices in Africa (Eritrea, Ivory Coast, Somalia, Djibouti and Ethiopia), Asia (Dubai, and India) and Latin America (Panama).
The consortium brings together leading partners covering the whole value chain and ensuring exploitation of the results. It is clearly industry driven, and it gives European industry the chance to take the lead of the ED revival and face the competition from the US that is also actively pursuing this important growth market. | project/european |
GB 2219559 A | Vibrator | 856,238. Earth-excavating equipment; boring earth. INDUSTRIKOMPANIET A.B. June 29, 1959 [July 1, 1958], No. 22195/59. Classes 68(1) and 85. [Also in Group XXIX] A liquid-pressure engine for excavating, drilling rock &c., comprises a piston 42 reciprocatable in a cylinder 31 and connected by an element 37 and a spring system 44, 44a to a valve 36, 38, which is moved in accordance with the movements of the piston to connect the cylinder to a source of liquid 60 or to an outlet 63, the spring system being in a chamber 43b connected by at least one passage 55 to an outlet 64 for discharging liquid from the chamber to prevent pressure therein affecting operation of the engine. The lower surface of the piston is permanently connected to the source 60, and the upper surface alternately connected to the source and the outlet 63 by the valve which is connected to the piston by the element 37 in the form of a spindle and the springs 44, 44a engaging an abutment 43.in the chamber 43b formed in the piston rod, piston, valve chamber or valve casing, the valve thus being moved with a time-lag in accordance with the movements of the piston which are of high frequency, e.g. 6000 strokes/min. The valve chamber 43b is connected to the outlet by passages 55 in an extension of the piston or by a passage in the spindle 37. A single spring may be used. The frequency and amplitude of the movement of the piston may be varied by modifying the dimensions of the springs or by controlling the pressure of the supply of liquid. Specifications 814,240, 856,239 and 856,240 are referred to. | patent |
interreg_2341 | Monitoring Network in the Alpine Region for Persistent and Other Organic Pollutants | The natural heritage, particular forests as prevailing alpine ecosystem type, play a crucial role for a sustainable development in the Alps. Important functions are the protection from avalanches and mudflows, the economic dimension of forestry, the drinking water supply, the re-creative features for tourism and the biodiversity aspects. Pollutant input endanger this natural heritage and its functions. Particularly the impact of highly toxic and accumulating organic pollutants (POPs) has been long time underestimated. The Alps seem to be a major sink for such by wind long-range transported and globally distributed POPs. As pilot project, MONARPOP will assess for the first time the load of the Alps with POPs (phase 1) and establish - on basis of the results - conclusions (e.g. a common declaration) and implementation steps to reduce this load (phase 2). Target groups for the dissemination of conclusions, for awareness raising and for implementation steps will be local to national authorities, environmental, industrial and agricultural NGOs and international fora under the UN (UNEP-Convention and UN-ECE Protocol on POPs) and the EU. | project/regional |
W2040420004 | Towards Low Carbon City Planning in a Medium Sized Low Density City | Abstract Adelaide is a medium sized low density city located in south eastern Australia. Typical of highly urbanized Australia, where abundant land and low cost private transport contribute to urban sprawl in all major cities, Adelaide is poorly placed to move to a low carbon future, despite access to abundant renewable resources and a favourable policy environment. Australians have some of the highest emissions per capita in the world. This study examines the spatially explicit nature of CO 2 emissions across the metropolitan area and explores the relationships between emissions and a range of socio-economic variables. Contrary to findings from other westernized cities, incomes, rents and housing prices are not well correlated with distance from the city centre or train stations. Household emissions are strongly correlated with household size, rooms per household and number of motor vehicles per household. Household emissions are therefore highly associated with private car use and daily commuting distances. Public transport is poorly utilized and many urban residential areas surrounding the most heavily used public transport routes also have very high household emissions. Attitudinal change to car and public transport use is therefore essential if Australian cities such as Adelaide are to move towards a low carbon future, and governments must design and implement policies which can achieve such change. | publication |
US 0236961 W | THREE AXIS MAGNETIC BEARING HAVING PERMANENT MAGNETS | An improved magnetic bearing that uses permanent magnets (28, 30) to provide the bias flux. The magnetic circuits generating the control flux and bias fluxes are substantially non-coincident but share the same path over some portions that include radial and axial air gaps allowing for a low reluctance and an efficient path for the electromagnetic flux. A single coil (22) and amplifier for the axial force control and two coils (26) with one associated amplifier for each radial axis of control provides simplicity and cost effectiveness. A single thrust disk is provided that is reacted against for both radial and the axial displacement. The permanent magnets (28, 30) used in the present invention are first fabricated and axially magnetized as segments or as continuous rings prior to being mounted on the sides of the rotor pole. | patent |
interreg_929 | Cross the line, weave a story - The search for oral traditions through tales and meetings at the border | This project aims at providing students with the opportunity to get acquainted with and discover common cultural roots of this cross-border area where different cultures coexist, by contributing in person to the drawing up of a didactic course. The main theme of the project consists in connecting a series of events to social entertainment and the organisation of several leisure opportunities, with particular emphasis on fairy tales, habits and customs that characterise the various phases of a person’s life. In order to better understand these research elements and analyse their peculiarities participants study the written sources on the various subjects. This work is further enriched by a search on-site, starting from the family environment to expand to complex social contexts (children, youth, adults, elderly). The project intends to identify and bring to the fore a connection among the elements detected in the tales and the events that mark the passages in the life of every individual. The attention of the young researchers will focus on the identification of moral teachings and the psychological traits of the characters. Also, they try to pinpoint the tales that offer different ways of representing a certain occurrence, in order to identify elements that are shared by various cultures and different geographical areas. The project also gives the students the opportunity to put in place an articulated research that requires their active participation in the definition of their study areas, the identification of adequate research tools, the drawing up of criteria for the purpose of comparison and the production of a single paper containing a critical evaluation on the work performed. | project/regional |
W4225408603 | La educación intercultural bilingüe en Ecuador: Historia, discursos y prácticas cotidianas | En 1988 se institucionalizaba en Ecuador el primer modelo educativo bilingüe en Latinoamérica manejado de manera autónoma por un movimiento social indígena. La voluntad era desafiar a las jerarquías del saber y a una sociedad excluyente. Desde el periodo colonial, se había confinado a la población indígena, sus idiomas, conocimientos y prácticas a una condición subalterna y de invisibilidad. Se lo había hecho mediante discursos y medidas que imaginaron y fabricaron ‘el otro en cuanto otro’, y lo redujeron al espacio del no humano, para legitimar la explotación y la opresión. El movimiento indígena, creador del proyecto, irrumpió en la historia con el levantamiento de 1990, y se presentó como fuerza subversiva cuyo fin era descolonizar el imaginario racista ecuatoriano. Propuso un reto político y epistemológico, para construir lo que el pensamiento crítico latinoamericano ha llamado ‘interculturalidad crítica’. Esta propuesta, diferente al multiculturalismo, se forja en un contradiscurso que se fundamenta en crear un grupo (‘nosotros, los indígenas’) ligado por siglos de discriminación, y una cultura ‘ancestral’ y ‘milenaria’, que se recrea y se reinventa al reivindicar una nueva identidad. En este libro la autora analiza las razones históricas por las cuales emergió el proyecto de Educación Intercultural Bilingüe (EIB) en Ecuador. Además, las tensiones entre este, orientado a descolonizar el saber y a subvertir las jerarquías racializadas, y cómo se aplicó en un Estado que se declara ‘intercultural y plurinacional’. Mediante un análisis históricamente fundado y sólidamente anclado en el trabajo de campo, tratará de responder a las múltiples cuestiones que se plantean en la práctica cotidiana del proyecto. | publication |
W1560850590 | การประเมินผลโปรแกรมคอมพิวเตอร์ช่วยสอน เรื่อง เภสัชจลนศาสตร์ของยาฟีไนโตอิน Assessment of Computer-Assisted Instruction for Pharmacokinetics of Phenytoin | Objective: To assess effectiveness of computer-assisted instruction (CAI)program on pharmacokinetics of phenytoin compared with conventionallearning, and to determine satisfaction on the use of the CAI. Methods:The CAI was tested by the 4th year pharmacy students in the 2nd semesterof the academic year of 2013. The students had learned thepharmacokinetics of phenytoin in a class lecture. Students were allocatedto 2 groups by stratified random sampling based on percentile of their GPA.The control group (n = 37) learned through self-study plus exercisescourse-pack while intervention group (n = 37) through the CAI program.The CAI program was divided into 3 parts, a profile of phenytoin, phenytoinpharmacokinetics, and phenytoin level calculation with exercises. Pre-testand post-test scores were compared statistically. Results: In each of thetwo groups, post-test score was statistically significantly higher than pretestscore (P < 0.001 for both groups). However, there was no significantdifference in post-test scores between groups. Among students withmedium to high GPA level, post-test score of intervention group wassignificantly higher than control group (9.38 0.74 and 8.00 1.32 points,respectively, P = 0.028). Satisfaction to the CAI program was in a goodlevel. Conclusion: A CAI program on phenytoin pharmacokineticsimproves the understanding of the learners after the lecture class.Keywords: computer-assisted instruction, CAI, pharmacokinetics, phenytoin | publication |
W2065246080 | FRAMEWORK-BASED DATA REQUIREMENTS FOR IT TOP MANAGEMENT | There are several challenges on the adoptions of the frameworks (e.g., standards). If the main target is semantic interoperability, then data should be taken into consideration. The main aim of this paper is to identify some mechanisms that take closer to the semantic interoperability. Therefore, the framework-based lessons for top management are based on the asset management standard (ISO 55001:2014 where data are one type of assets) and enterprise architecture metamodel (TOGAF content metamodel). The results establish that none of the asset management requirements for top management mentions data and the attributes of the data entity do not support the semantics interoperability. | publication |
W2069141631 | Novel patterns for the growing main bronchi in the human fetus: an anatomical, digital and statistical study | Intensive progress in prenatal medicine results in performing airway management in the fetus affected by life-threatening congenital malformations. This study aimed to examine age-specific reference intervals and growth dynamics for length, proximal and distal external transverse diameters, and projection surface areas of the two main bronchi at varying gestational ages, including their relative growth in length and projection surface area.Using anatomical dissection, digital image analysis and statistics, length, proximal and distal external transverse diameters, and projection surface areas of the right and left main bronchi were examined in 73 human fetuses (39 males, 34 females) aged 14-25 weeks, derived from spontaneous abortions and stillbirths.Statistical analysis showed no sex differences. Between the 14 and 25th week of gestation, the lengths of the right and left main bronchi increased from 1.43 ± 0.18 to 3.18 ± 0.39 mm, and from 2.97 ± 0.16 to 7.58 ± 1.95 mm, in accordance with the functions: [Formula: see text], respectively. The proximal external transverse diameters of the right and left main bronchi varied from 2.13 ± 0.41 to 4.24 ± 0.20 mm, and from 1.84 ± 0.06 to 3.67 ± 0.66 mm, following the logarithmic models: [Formula: see text], respectively. The distal external transverse diameter rose from 2.09 ± 0.47 to 4.24 ± 0.20 mm, as [Formula: see text] for the right main bronchus, and from 1.85 ± 0.04 to 3.67 ± 0.66 mm, like [Formula: see text] for the left one. On either side, there were no statistically significant differences between values of the proximal and distal transverse diameters of the main bronchus. The projection surface areas of the right and left main bronchi ranged from 2.95 ± 0.19 to 13.34 ± 2.12 mm(2), and from 5.57 ± 0.21 to 28.52 ± 5.24 mm(2), as [Formula: see text] and [Formula: see text]. The two main bronchi revealed a proportionate increase in both length and projection surface area, since the right-to-left bronchial length ratio and the right-to-left bronchial projection surface area ratio were stable, 0.41 ± 0.07 and 0.47 ± 0.08, respectively, throughout the analyzed period.The main bronchi show no sex differences. The right and left main bronchi grow logarithmically in length and external transverse diameter, and linearly in projection surface area. The right and left main bronchi evolve proportionately, with the right-to-left bronchial ratios of 0.41 ± 0.07 for length, and 0.47 ± 0.08 for projection surface area. | publication |
W2328707315 | Stability of a Floquet Bose-Einstein condensate in a one-dimensional optical lattice | Motivated by recent experimental observations (C.V. Parker {\it et al.}, Nature Physics, {\bf 9}, 769 (2013)), we analyze the stability of a Bose-Einstein condensate (BEC) in a one-dimensional lattice subjected to periodic shaking. In such a system there is no thermodynamic ground state, but there may be a long-lived steady-state, described as an eigenstate of a "Floquet Hamiltonian". We calculate how scattering processes lead to a decay of the Floquet state. We map out the phase diagram of the system and find regions where the BEC is stable and regions where the BEC is unstable against atomic collisions. We show that Parker et al. perform their experiment in the stable region, which accounts for the long life-time of the condensate ($\sim$ 1 second). We also estimate the scattering rate of the bosons in the region where the BEC is unstable. | publication |
W2165367048 | CHINESE CONSUMER PERCEIVED RISK AND RISK RELIEVERS IN E-SHOPPING FOR CLOTHING | Online perceived risk is an important issue in e-commerce. As China has a large Internet shopper population and online consumer spending continues to increase, better understanding Chinese online shoppers’ perceived risk and risk reduction strategies becomes particularly relevant. However, research in the Chinese context is limited. Given this reality, the purpose of this study is to (1) identify and rank Chinese consumer online perceived risk; (2) investigate consumer preferences for methods of reducing risk; and (3) present a cluster analysis of e-shoppers based on their perceived risk score. Managerially, the study intends to provide e-marketers and e-retailers with an overview of risk as perceived by Chinese online shoppers and their risk reduction strategies. It also aims to demonstrate for managers the impact of this awareness on their competitiveness by illustrating how consumer types are related to different perceived risk dimensions and risk reliever strategies on the Internet. Some results from this study are consistent with previous studies, but it is interesting to note that certain findings are different. These differences might be explained by the specificity of the Chinese Internet shopping environment and Chinese culture. Cluster analysis regrouped the Chinese e-shoppers into five groups based on their perceived risk. | publication |
W2329372874 | Non-linear response of buckled beams to 1:1 and 3:1 internal resonances | Abstract The non-linear response of a buckled beam to a primary resonance of its first vibration mode in the presence of internal resonances is investigated. We consider a one-to-one internal resonance between the first and second vibration modes and a three-to-one internal resonance between the first and third vibration modes. The method of multiple scales is used to directly attack the governing integral–partial–differential equation and associated boundary conditions and obtain four first-order ordinary-differential equations (ODEs) governing modulation of the amplitudes and phase angles of the interacting modes involved via internal resonance. The modulation equations show that the interacting modes are non-linearly coupled. An approximate second-order solution for the response is obtained. The equilibrium solutions of the modulation equations are obtained and their stability is investigated. Frequency–response curves are presented when one of the interacting modes is directly excited by a primary excitation. To investigate the global dynamics of the system, we use the Galerkin procedure and develop a multi-mode reduced-order model that consists of temporal non-linearly coupled ODEs. The reduced-order model is then numerically integrated using long-time integration and a shooting method. Time history, fast Fourier transforms (FFT), and Poincare sections are presented. We show period doubling bifurcations leading to chaos and a chaotically amplitude-modulated response. | publication |
US 2019/0038791 W | RIDING CROP APPARATUS FOR STRIKING A HORSE | A riding crop for striking a horse having a shaft formed of a rigid interior pole having a resilient exterior cover and a unitary popper is defined by an elongated body. The riding crop additionally includes a handle covering or positioned adjacent to the proximal end of the shaft. The popper is positioned over or adjacent to the distal end of the shaft, with the shaft extending between the handle and the popper. The handle provides a surface that allows a user to hold the riding crop and the popper is the portion of the riding crop intended to contact a horse. The popper is defined by an oblong, bulbous member which is formed as a unitary one-piece structure and which includes an aperture that extends longitudinally through the popper from the end which forms the distal end to the shaft | patent |
636795 | Ecological diversity of land vertebrates through the largest extinction in earth history | Contemporary Earth’s ecosystems are threatened by accelerating extinction rates, but their responses to biodiversity losses are not detectable on short time scales. However, many large-scale biodiversity crises, or ‘mass extinctions’, occurred in the past and played a fundamental role in evolution. For instance, modern-style ecosystems originated from the worst biodiversity crisis in Earth history (PTME) at the Permian-Triassic boundary (~252 million years ago). The PTME killed over 70% of vertebrate species and created opportunities for new groups to diversify. After the extinction, Triassic land vertebrate assemblages were transformed, and new species diversified in ecological roles that were unexploited in Permian ecosystems. This suggests that extinctions may change the evolutionary trajectory of ecosystems and increase ecological complexity. Nevertheless, the ecological impacts of mass extinctions on ecosystems are still poorly understood. For the first time, this project critically investigates how the ecological structure and composition of land ecosystems changed across the PTME and its connection to biodiversity recovery. We will target the fossil record of exceptionally preserved Permian-Triassic ecosystems, alongside new field data from critical, but poorly sampled time intervals. Using a suite of novel approaches modified from modern ecology, we will quantify changes in ecological diversity, richness and stability of land ecosystems and major vertebrate groups. These patterns will be used to understand what factors drive biodiversity and the evolution of ecosystems during and after times of crisis. Through a comprehensive training and knowledge exchange programme, the experienced researcher and hosts will bring together and integrate their expertise in palaeontology, biology, quantitative techniques, and macroevolution to deliver this timely, innovative, and interdisciplinary project that will address fundamental ecological questions. | project/european |
W4310803272 | Du couvent au collège : relations, circulations et conflits entre San Pablo et San Gregorio à Valladolid | Cet article vise à explorer la relation entre deux importantes institutions dominicaines basées à Valladolid. Toutes deux ont joué un rôle clé dans la promotion et la consolidation de la réforme de l'Ordre en Castille à la fin du xve siècle. La fondation du Colegio de San Gregorio en 1487 par Alonso de Burgos, frère dominicain et évêque de Palencia, sur des terres cédées par le couvent voisin de San Pablo, marque le début de ces relations tortueuses. Cependant, le souhait du prélat, selon les statuts du Collège, était de garantir une vie harmonieuse entre les deux communautés. L'article analyse comment la disposition du collège a été conçue en fonction du passage des frères du couvent au collège, pour suivre des cours universitaires, et vice versa. | publication |
W2183782098 | Analyzing and Enforcing Security Mechanisms on Requirements Specifications | [Context and motivation] Security mechanisms, such as firewalls and encryption, operationalize security requirements, such as confidentiality and integrity. [Question/problem] Although previous work has pointed out that the application of a security mechanism affects system specifications, there is no systematic approach to describe and analyze this impact. [Principal ideas/results] In this paper, we investigate more than 40 security mechanisms that are well documented in security pattern repositories in order to better understand what they are and how they function. [Contribution] Based on this study, we propose a conceptual model for security mechanisms, and evaluate this model against 20 security mechanisms. Using the conceptual model, we provide a systematic process for analyzing and enforcing security mechanisms on system requirements. We also develop a prototype tool to facilitate the application and evaluation of our approach. | publication |
Q4247861 | LIQUIDITY SUPPORT FOR MICRO-ENTERPRISES AFFECTED BY THE COVID EMERGENCY | SUPPORT FOR THE LIQUIDITY OF MICRO AND SMALL ENTERPRISES IN THE RETAIL, SUPPLY AND PERSONAL SERVICES SECTORS WHOSE ACTIVITY HAS BEEN SUSPENDED AS A RESULT OF THE PRIME MINISTERIAL DECREE OF 11 MARCH 2020 | project/regional |
Q3275992 | JPTT20-COVID19-AMA-SEO | optimiser le site web www.rogac.eu et faire de la boutique Amazon:- Activité a) Vendre sur des plateformes internationales de vente en ligne mondiales, — Activité e) Optimisation des sites web et des canaux de vente numériques, mise en place de systèmes mesurant les effets des communications numériques et des systèmes de suivi pour les clients potentiels dans le cadre des canaux de vente numériques, tous destinés aux clients étrangers/entreprises étrangères | project/regional |
US 2017/0030329 W | HIGH TRIP RATE DRILLING RIG | A high trip rate drilling rig has first handling equipment to transport stands in/out of setback, second handling equipment to deliver stands to/from well center, and a hand-off position to set down stands for exchange between first/second equipment. Second equipment can include a top drive and a delivery arm translatable along the mast past each other, and a clasp on the arm slidable on the stand for constraint below the upper end, which can allow the top drive to engage/disengage the constrained stand above the arm. A high trip rate method transports stands in/out of setback, delivers stands to/from well center, and sets down and hands off stands at hand-off position between the setback transportation and well center delivery. The delivery can include engaging/dis engaging the top drive and a stand constrained by the clasp. | patent |
216200 | Demonstration of integrated solution for offshore tocardo tidal power plants. | Tocardo International has in the past ten years developed a technology for tidal turbines for generating tidal power from flowing water. For offshore application, integrated tidal system are needed that require low upfront investments (CAPEX), have low maintenance and operation costs (OPEX) and produce large amount of kWh. Tocardo International has developed an solution which fulfils these requirements.
The objective of the InToTidal project is to execute the last step of the develop and demonstration of an integrated and generic solution for offshore tidal energy production, making it ready for successful commercial business application. The system will be tested and demonstrated in this project, while the resulting system will be used for long term testing after the project.
Tocardo formed a strong consortium with EMEC, Infremer and LEASK Marine to be able to make this project a success.
With a large market potential and strong competitive position, Tocardo is able to grow into a strong and powerful company with annual turnover of more than 180 Mio Euro per year within 3 years (providing work to 60 own employed FTE’s in 2020) and growing towards a 1,0 Billion euro turnover in 2025 providing jobs for 600 own personnel in 2025 as well as >1000 jobs in the supply chain. | project/european |
W1938178934 | Membrane-Associated Glucose-Methanol-Choline Oxidoreductase Family Enzymes PhcC and PhcD Are Essential for Enantioselective Catabolism of Dehydrodiconiferyl Alcohol | ABSTRACT Sphingobium sp. strain SYK-6 is able to degrade various lignin-derived biaryls, including a phenylcoumaran-type compound, dehydrodiconiferyl alcohol (DCA). In SYK-6 cells, the alcohol group of the B-ring side chain of DCA is initially oxidized to the carboxyl group to generate 3-(2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydrobenzofuran-5-yl) acrylic acid (DCA-C). Next, the alcohol group of the A-ring side chain of DCA-C is oxidized to the carboxyl group, and then the resulting metabolite is catabolized through vanillin and 5-formylferulate. In this study, the genes involved in the conversion of DCA-C were identified and characterized. The DCA-C oxidation activities in SYK-6 were enhanced in the presence of flavin adenine dinucleotide and an artificial electron acceptor and were induced ca. 1.6-fold when the cells were grown with DCA. Based on these observations, SLG_09480 ( phcC ) and SLG_09500 ( phcD ), encoding glucose-methanol-choline oxidoreductase family proteins, were presumed to encode DCA-C oxidases. Analyses of phcC and phcD mutants indicated that PhcC and PhcD are essential for the conversion of (+)-DCA-C and (−)-DCA-C, respectively. When phcC and phcD were expressed in SYK-6 and Escherichia coli , the gene products were mainly observed in their membrane fractions. The membrane fractions of E. coli that expressed phcC and phcD catalyzed the specific conversion of DCA-C into the corresponding carboxyl derivatives. In the oxidation of DCA-C, PhcC and PhcD effectively utilized ubiquinone derivatives as electron acceptors. Furthermore, the transcription of a putative cytochrome c gene was significantly induced in SYK-6 grown with DCA. The DCA-C oxidation catalyzed by membrane-associated PhcC and PhcD appears to be coupled to the respiratory chain. | publication |
US 201916417627 A | UPDATING SOFTWARE COMPONENTS THROUGH ONLINE STORES | The present invention extends to methods, systems, and computer program products for updating software components through online stores. A computing device interacts with an online store to download applications and frameworks that are distributed from the online store. The computer system includes an operating system configured to keep distributed applications and frameworks updated. The operating system can, automatically and without user intervention, intelligently schedule and attempt application and framework updates in a manner that minimizes user disruptions. The operating system can manage application and framework updating for any and/or all user accounts on a computing device. The operating system can manage updates even when each application and/or framework is to be separately installed for different user accounts that have the application and/or framework installed. | patent |
US 0341493 W | THIOSEMICARBAZONES AS ANTI-VIRALS AND IMMUNOPOTENTIATORS | Novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, as well as novel methods for treating viral infections, including HCV, by administering the compounds and compositions, and novel methods for modulating the immune response by administering the compounds and/or compositions. | patent |
216056 | Homo mimeticus: theory and criticism | Mimesis is one of the most influential concepts in Western thought. Originally invoked to define humans as the “most imitative” creatures in classical antiquity, mimesis (imitation) has recently been at the centre of theoretical debates in the humanities, social sciences, and the neurosciences concerning the role of “mimicry,” “identification,” “contagion,” and “mirror neurons” in the formation of subjectivity. And yet, despite the growing confirmations that imitation is constitutive of human behaviour, mimesis still tends to be confined to the sphere of realistic representation. The HOM project combines approaches that are usually split in different areas of disciplinary specialization to provide a correction to this tendency.
Conceived as a trilogy situated at the crossroads between literary criticism, cinema studies, and critical theory, HOM’s outcomes will result in two monographs and accompanying articles that explore the aesthetic, affective, and conceptual implications of the mimetic faculty. The first, radically reframes a major proponent of anti-mimetic aesthetics in modern literature, Oscar Wilde, by looking back to the classical foundations of theatrical mimesis that inform his corpus; the second considers the material effects of virtual simulation by looking ahead to new digital media via contemporary science-fiction films; and the third establishes an interdisciplinary dialogue between philosophical accounts of mimesis and recent discoveries in the neurosciences. Together, these new perspectives on homo mimeticus reconsider the aesthetic foundations of a major literary author, open up a new line of inquiry in film studies, and steer philosophical debates on mimesis in new interdisciplinary directions. | project/european |
W2062270549 | Onset of Convective Rainfall During Gradual Late Miocene Rise of the Central Andes | Separated About Lift The uplift history of the Andes of South America is a contentious issue, with the two main hypotheses polarizing from rapid growth between roughly 10 and 7 million years ago to more gradual elevation over most of the past 40 million years. The oxygen isotopic composition of soil carbonates has been used as a proxy for altitude and to measure the timing of uplift. Poulsen et al. (p. 490 , published online 1 April) applied a global atmospheric general circulation model to show that the oxygen isotopic composition changes seen in carbonates formed in the late Miocene were driven more by changes in the amount of precipitation than by the altitude at which the precipitation forms. Consequently, it seems that oxygen isotopes are not a reliable paleoaltimeter, and Andean uplift may not have been as precipitate as thought. | publication |
W2552299587 | Transient deformation of karst aquifers due to seasonal and multiyear groundwater variations observed by GPS in southern Apennines (Italy) | We present GPS, hydrological, and GRACE (Gravity Recovery and Climate Experiment) observations in southern Apennines (Italy) pointing to a previously unnoticed response of the solid Earth to hydrological processes. Transient patterns in GPS horizontal time series near to large karst aquifers are controlled by seasonal and interannual phases of groundwater recharge/discharge of karst aquifers, modulating the extensional similar to 3 mm/yr strain within the tectonically active Apennines. We suggest that transient signals are produced, below the saturation level of the aquifers and above a poorly constrained depth in the shallow crust, by time-dependent opening of subvertical, fluid-filled, conductive fractures. We ascribe this process to the immature karstification and intense tectonic fracturing, favoring slow groundwater circulation, and to multiyear variations of the water table elevation, influenced by variable seasonal recharge. The vertical component displays seasonal and multiyear signals more homogeneously distributed in space and closely correlated with estimates of total water storage from GRACE, reflecting the elastic response of the lithosphere to variations of surface water loads. The different sensitivities of vertical and horizontal components to the hydrologically induced deformation processes allow us to spatially and temporally resolve the different phases of the water cycle, from maximum hydrological loading at the surface to maximum hydrostatic pressure beneath karst aquifers. Finally, we suggest that transient deformation signals in the geodetic series of the Apennines are correlated to large-scale climatic patterns (Northern Atlantic Oscillation) through their influence on precipitation variability and trends at the regional scale. | publication |
Q82494 | Mould production technology for internal combustion engine blocks castings | “The aim of the project is to implement an integrated technology for the production of specialised foundry pressurised moulds for the production of internal combustion engine blocks for the automotive industry. One of the key elements of the above-mentioned integrated technology is the technology of making sockets for thermocouple sensors in a housing of deep (40 cm) sockets while maintaining a narrow dimensional tolerance, i.e. > 0,01 mm (to date tolerance not exceeding 0,1 mm). This technology, in the form of a technological line for honing (working holes for thermopolar sensors) was filed for a patent claim as an invention in October 2015 BC. “Honing Machine” under number P.414371. The main objective of the project will therefore be to introduce a new generation of foundry pressurised moulds on the domestic and international market as a product for the foundry industry focused on production for the automotive industry. “ | project/regional |
223547 | Enhancing brain function and cognition via artificial entrainment of neural oscillations | Neural oscillations are ubiquitous in the human brain and have been implicated in diverse cognitive functions to support both neural communication and plasticity. Their functional relevance is further supported by a large number of studies linking various cognitive deficits (e.g., attention deficit hyperactivity disorder, ADHD) with abnormal neural oscillations. However, this field of research faces two important problems: First, there is only correlative, but no causal evidence linking cognitive deficits to abnormal neural oscillations in humans. Second, there is virtually no theory-driven mechanistic approach that generates insights into how oscillations within and across neural networks are linked to human behavior. In this project, I propose to take decisive steps to provide a long-needed neurophysiological characterization—via (1) computational modelling, (2) electrophysiological measures, and (3) novel non-invasive manipulations of cortical rhythms—on how neural oscillations contribute to two types of cognitive processes that are fundamental for many aspects of human behavior: attention and short-term memory. I will go a step further by demonstrating that it is possible to augment performance in these cognitive functions with the design of non-invasive brain stimulation protocols individually tailored to the theory-driven neurocomputational characterizations and electrophysiological signatures of each individual. This will result in the applied goal of deriving new neuro-computational assays that can detect deviant network interactions causally related to cognitive functions, which is key for then renormalizing those functions in neuropsychological conditions such as ADHD. Thus, if successful, my proposed work will ultimately result in novel, low-cost, and painless non-invasive neural interventions for a wide range of neuropsychological disorders tied to abnormal neural oscillations. | project/european |
W2005570655 | Transit time of CME/shock associated with four major geo-effective CMEs in solar cycle 24 | Abstract The kinematics of coronal mass ejection (CME) in the interplanetary medium is very important in the concept of space-weather. Main aim of this paper is to study the propagation of four major geo-effective CMEs and their associated shocks observed in solar cycle 24. The arrival of interplanetary shocks and CMEs of these events near the Earth is seen from the ACE/wind in situ data available in OMNI data base. The CMEs considered in this study have a wide range of initial speeds 500–1900 km/s in the LASCO field of view, comprising of two slow CMEs ( V ∼ 500 km/s), one fast CME ( V ∼ 1800 km/s) and one moderate speed CME ( V ∼ 800 km/s). The observed transit time of these events are compared with transit time estimated using the empirical shock arrival model (ESA). Especially, we utilize (i) different acceleration – speed equations reported in the literature from the observations made in the last few decades and (ii) various acceleration cessation distances ( Acd ) In addition, we compared the estimated and observed transit time with that from the Drag Based Model (DBM). From the result of this analysis, we demonstrated that each CME behaves in its own way in the interplanetary medium and their propagation is governed by the CME initial speed, interplanetary acceleration and acceleration cessation distances. In the present paper, we found (i) which acceleration equation is better for the transit time calculations (ii) importance of the CME acceleration cessation distances (iii) reducing the transit time error in CME forecasting. Based on these results and on Zhao and Dryer (2014) review (that included physics-based models), the realistic statistics should be based on real-time studies, not on post-mortem case studies. | publication |
W2069783333 | Two-Dimensional Monte Carlo Simulation of DGSOI MOSFET Misalignment | In this paper, we investigate the gate misalignment effects in a 10-nm double-gate silicon-on-insulator MOSFET transistor with a 2-D Monte Carlo simulator. Quantum effects, which are of special relevance in such devices, are taken into account by using the multivalley effective conduction-band-edge method. Different gate misalignment configurations have been considered to study the impact on device performance, finding a current improvement when the gate misalignment increases the source-gate overlapping. Moreover, our results show that a 20% gate misalignment can be assumed for a drain current deviation smaller than 10%. Finally, the validity of the obtained results was assessed with a set of simulations for devices that have different gate lengths, silicon thicknesses, and oxide thicknesses. | publication |
224792 | Linking singularity theory and representation theory with homological methods | In algebraic geometry one tries to understand and explain geometric phenomena of zerosets of polynomial equations (algebraic varieties) with algebraic techniques. Singularities of algebraic varieties are, roughly speaking, points of indeterminacy, where most analytical methods collapse. Geometrically, this corresponds e.g. to cusps or crossing points. In a practical example, the arm of a robot can break if it passes through a singular point, which could result in a complete breakdown of the system. Such a situation should be avoided by theoretical considerations.
This project lies at the intersection of singularity theory, (non-commutative) algebraic geometry, commutative algebra, and representation theory. The main goal is to develop homological methods to understand geometric phenomena of algebraic varieties in the presence of singularities and use them to study representation theoretic concepts such as cluster categories and friezes. The project will provide a bridge between these seemingly distant areas that can be exploited in both directions.
The specific research objectives:
(1) Construction of noncommutative (crepant) resolutions of singularities (NC(C)Rs), in particular for not necessarily normal varieties/rings: computation of global dimension, application to positive characteristic (global dimension of ring of differential operators)
(2) McKay correspondence for reflection groups: study of the geometry of discriminants of pseudo-reflection groups and their relation to the representation theory of the groups, characterization of McKay quivers
(3) Friezes and singularities: show how (higher) integral friezes can be constructed from cluster categories and categories of maximal Cohen-Macaulay modules
The project will be carried out by Eleonore Faber, supervised by Robert Marsh at the University of Leeds. Apart from the scientific value, this project should serve to integrate Faber in the algebra research group and to establish her as a research leader. | project/european |
171066 | Nanostructured oxide and silicide materials for thermoelectric device applications | The impacts of energy and financial crisis along with climate change have generated the necessity of cheap sustainable green energy. Against this background EU set targets for reducing greenhouse gas emissions, increasing the share of renewables in final energy consumption and increase in energy efficiency for the next years. Upgrading the otherwise lost waste heat, which is estimated to be over 60% of the globally released energy, to electrical energy is a promising strategy for sustainable energy. The use of thermoelectric devices which convert directly the waste heat to electrical energy, is a desirable technology for future power generation. Despite the big effort of the last years their conversion efficiency is quite low and the thermoelectric materials that are currently used are based on Tellurium, which is very rare on the earth surface. In this proposal we suggest the use thermoelectric materials based on Silicides and Oxides, which are abundant on the earth surface and relatively cheap. The aim is the optimization of synthesis and processing conditions using the state of the art panoscopic approach in combination, for first time, with tunable porosity which is expected to further enhance their efficiency. The fabricated nanostructured bulk thermoelectric materials will be characterized with several experimental techniques and studied through theoretical calculations. Technical improvement of some techniques will be performed for better characterization of the fabricated materials. This proposal also involves applied research in the form of construction and characterization of a prototype thermoelectric device using the fabricated materials. | project/european |
175142 | Optimal lightning protection system | EU has set the goal that 20% of our energy should come from renewable sources by 2020. The impact of lightning strikes on wind turbines has long been an issue for the industry. Already in the technical report from IEC published in 1998 (IEC TR 61400-24) blade damages was contributing with the highest repair cost, and the longest outage time. This tendency has continued the last decade, where the blade lengths have increased from 20-30m to blade lengths of 60-80m. Specifically, lightning-related failures and consequent maintenance and repair activities is the primary cost in operating wind turbines, for instance a lightning strike offshore can cost up to €1.5 million when accounting for the expenses related to crane vessel, offshore repair operations and loss in energy production.
Currently, all OEMs implement lightning protection systems (LPSs) in their blades. However, laboratory experiments and field experience often find these protection systems inefficient. This has drastic economic consequences for wind farms owners/operators.
The Opti-LPS project mitigates this problem by developing an innovative new blade agnostic LPS product, increasing the protection efficiency (interception and lightning current conduction), lowering the costs of the LPS system, and greatly simplifying the installations and logistics compared to recent solutions seen at many manufacturers. The consequence is a lowering of initial costs and servicing that ultimately increases the economic feasibility of wind turbines.
The innovation project will bring the Opti-LPS closer to market by design optimisation, work flow optimisation and demonstrations using prototypes.
The feasibility study comprises of: a market study, feasibility of technical and economic factors and development of a business plan. | project/european |
EA 200200439 A | METHOD AND SYSTEM FOR SIMULATING A HYDROCARBON-BEARING FORMATION | 1. A method for simulating one or more characteristics of a multi-component, hydrocarbon-bearing formation wherein a fluid comprising at least one component is injected into the formation through at least one well to displace hydrocarbons in the reservoir, comprising the steps of: (a) equating the formation in at least one dimension to a multiplicity of gridcells; (b) dividing at least some of the gridcells into two or more regions, a first region representing a portion of each gridcell swept by the displacement fluid and a second region representing a portion of each gridcell essentially unswept by the injected fluid, the distribution of components in each region being essentially uniform; (c) constructing a model representative of fluid properties within each region, fluid flow between gridcells using principles of percolation theory, and component transport rate between regions ; and (d) using the model to simulate one or more characteristics of the formation. 2. The method of claim 1 wherein step (d) predicts a property of the formation and the fluids it contains as a function of time. 3. The method of claim 1 wherein the displacement fluid is miscible with hydrocarbons in the formation. 4. The method of claim 1 wherein the displacement fluid is multiple-contact miscible with hydrocarbons present in the formation. 5. The method of claim 1 wherein the displacement fluid is carbon dioxide. 6. The method of claim 1 wherein the displacement fluid comprises hydrocarbon gas. 7. The method of claim 1 wherein model constructed in step (c) is further representative of energy transport between gridcell regions. 8. The method of claim 1 wherein the displacement fluid is steam and the model of step (c) is further representative of energy transport between gridcell regions. 9. The method of claim 1 wherein the gridcells comprises unstructured gridcells. 10. The method of claim 1 wherein the gridcells are three-dimensional. 11. The method of claim 1 wherein the gridcells are two-dimensional. 12. The method of claim 1 wherein the model further takes into account component diffusion, dispersivity, and interfacial tension within each region. 13. The method of claim 1 wherein the component transport rate between regions is proportional to the driving force times resistance. 14. A method for simulating one or more characteristics of a multi-component, hydrocarbon-bearing formation into which a displacement fluid is injected to displace formation hydrocarbons present in the formation, comprising the steps of: (a) equating at least part of the formation to a multiplicity of gridcells ; (b) dividing each gridcell into two regions, a first region representing a solvent-swept portion of each gridcell and a second region representing a portion of each gridcell essentially unswept by the solvent, the fluid composition within each region being essentially uniform; (c) constructing a model comprising functions representative of the mobility of each phase in each region using principles of percolation theory, functions representative of the phase behavior within each region, and functions representative of the mass transfer of each component between the regions; and (d) using the model in a simulator to simulate production of the formation and to determine one or more characteristics thereof. 15. The method of claim 14 wherein steps (a) through (d) are repeated for a plurality of time intervals and using the results to predict a property of the reservoir and the fluids it contains as a function of time. 16. A system for determining one or more characteristics of a multi-component, hydrocarbon-bearing formation into which a displacement fluid having at least one component is injected to displace formation hydrocarbons, said model using a multiplicity of gridcells being representative of the formation, comprising (a) a model having each gridcell divided into two regions, a first region representing a portion of each gridcell swept by the displacement fluid and a second region representing a portion of each gridcell essentially unswept by the displacement fluid, the distribution of components in each region being essentially uniform and the mobility of fluids in each region being determined based on principles of percolation theory; and (b) a simulator, coupled to said model, to simulate the formation to determine the characteristic therefrom. 17. The system of claim 16 wherein the model is representative of fluid properties within each region, fluid flow between gridcells, and component transport between regions. 18. A method of simulating at least one component of a multicomponent fluid system in a hydrocarbon-bearing formation, whose characterizing features are described by a set of equations, by means of a simulator on a computer, the method comprising the steps of: (a) providing a model having each gridcell divided into two regions, a first region representing a portion of each gridcell swept by the displacement fluid and a second region representing a portion of each gridcell essentially unswept by the displacement fluid, the distribution of components in each region being essentially uniform and the mobility of fluids in each region being determined based on principles of percolation theory; and (b) using in the simulator the model thereby simulating changes of the component in the formation. | patent |
W4292808818 | DICTADURA, PODER ESTATAL Y GRANDES PROYECTOS EN REGIONES MARGINALES. LA AMAZONIA BRASILEÑA Y LA PATAGONIA ARGENTINA DURANTE LA DÉCADA DE 1960 Y 1970 | En América Latina, las décadas de 1960 y 1970 estuvieron atravesadas por regímenes dictatoriales que procuraban evitar el cuestionamiento de la dominación mediante el control social, en alianza con los intereses nacionales y transnacionales en pos de la expansión del capitalismo. Tanto en Brasil a partir de 1964 como en Argentina desde 1966, los gobiernos militares procuraron visibilizar el poder a través de grandes proyectos ubicados fundamentalmente en áreas consideradas marginales. En la Amazonia brasileña como en la Patagonia argentina, los megaproyectos formaron parte de un constructo ideológico destinado a resignificar esos espacios como parte de una política de crecimiento económico. El discurso oficial basado en la premisa del progreso, la grandeza y el desarrollo nacional se orientó a legitimar a la dictadura y acrecentar el consenso social. Este artículo se realiza sobre la base de fuentes primarias, fundamentalmente discursos presidenciales, artículos de revista y documentación oficial de organismos nacionales e internacionales. | publication |
US 201615278214 A | SCREEN PANEL LOCKING SYSTEM | A screening apparatus includes elongate beams and screen panels mounted to the beams to form a broad screening surface. Each of the panels are mounted so that side edges of adjacent panels are in facing relationship. Each panel is mounted to a pair of beams to bridge between two adjacent beams. The panels are mounted to the beams by fixing members. The fixing members have a pair of upstanding rails that are spaced apart to define a longitudinal gap between them. The panels are mounted to the beams by cooperation between the side edges with a rail of a fixing member. Cover strips extend along the beams and include a cover portion and a locking portion. The cover portion bears against an upper surface of a pair of adjacent panels and the locking portion bears against facing surfaces of the rails to resist movement of the rails towards each other. | patent |
W1549814571 | Uso eficiente y sustentable del agua | Water is not a natural resource more, is a vital resource that can fully explain the cycles of nature and the interactions between species and the environment they live under water cycle. But water resists man, so its use requires rational actions that should serve the welfare of society, in order to achieve what today is called quality of life in a healthy environment. To do this, water requires that the Water Policy determines the purposes; that the Water Plannins is reflected in Planning Plans, Stages and Programs; That the Water Legislation provide an appropriate regulatory framework, that the Water Administration take Policy into practice and that the Management is the central place that is linked to water use efficiency. | publication |
IB 2005054270 W | BRIDGE TYPE SENSOR WITH TUNABLE CHARACTERISTIC | A bridge type magnetic sensor is disclosed having four resistive elements in a bridge arrangement, two of the resistive elements on opposing sides of the bridge having a magnetoresistive characteristic such that their resistance increases with increasing positive magnetic field and with increasing negative magnetic field. A frequency doubling is obtained because the output characteristic of the magnetic sensor is a V-shaped curve, where the signal rises for increasing positive and negative fields. | patent |
interreg_2390 | Joint development of innovative processes and products based on local dairy and meat tradition pertaining to ruminant farming and relevant agri-food sectors | MeDInno project focuses on the ruminant farming and agri-food micro & small enterprises, through the development of innovative processes and products based in local dairy and meat tradition of the Programme area, in order to decrease the rural unemployment and poverty. Thanks to MeDInno project, new cheese and meat products will be developed through the knowledge transfer and the quality standardization and the promotion under an integrated brand strategy. The project will also implement two day trips for 5 top chefs to get familiar with the new products in combination with workshops for local chefs (one in Epirus and one in Puglia Region), five special presentation events in Foggia, Barletta, Bari, Lecce and Taranto and a series of local training seminars and workshops targeting at local stakeholders and farmers in the two regions. | project/regional |
TW 105138147 A | Photo-imageable thin films with high dielectric constants | A formulation for preparing a photo-imageable film; said formulation comprising: (a) a positive photoresist comprising a cresol novolac resin and a diazonaphthoquinone inhibitor; and (b) functionalized zirconium oxide nanoparticles. | patent |
EP 2018051219 W | SMOKE BARRIER SYSTEM | Use of a splinter binding and weight bearing foil (2) with an adhesive (3) and a glass pane (4) in a smoke barrier system (1). The smoke barrier system (1) comprises a fixation element (5). The adhesive (3) is arranged between the splinter binding foil (2) and the glass pane (4), wherein the splinter binding foil (2) is equipped to hold glass fragments of a glass pane (4) together in case of a glass breakage. The splinter binding foil (2) is arranged between the fixation element (5) and the glass pane (4), in particular the splinter binding foil (2) is clamped between the fixation element (5) and the glass pane (4). The splinter binding foil (2) is designed to detach from the glass pane (4) in the case of fire and/or temperature influence. | patent |
222634 | Tilt rotor heat exchanger | The overall objective of the project is to design, develop; manufacture and flight qualify a novel heat exchanger for oil cooling in the transmission system of a civil Tilt Rotor aircraft. The proposed solution will outperform a conventional plate-fin heat exchanger in terms of efficiency, volume, weight, robustness, reliability and will fully integrate into the transmission systems architecture.
The concept underpinning this project is to build upon Marston Aerospace’s long history of innovation within heat transfer and fluids management systems by forming an integrated project team. The team will consist of thermal modellers, mechanical design, manufacturing, experimentalists and R&D experts in order to propose three initial air cooled oil cooler designs based on different manufacturing technologies. These will be conventional plate and fin corrugated heat exchanger; chemically etched plate and pin and an additive layer manufacturing solution utilising a novel architecture. An assumption would be that the material which would be most appropriate, in terms of technology readiness and for each proposed manufacturing process the suitability would be aluminium and that the new designs will be directly compared to each other in order to select the most viable design to take forward through to prototype manufacture towards flight demonstration testing. | project/european |
216354 | Smart bi-directional multi energy gateway | Flexibility needs to be added to Europe’s power system to accommodate an increasing share of variable power generation from renewable sources. Indeed, service quality issues start to arise on the grid when this share in electricity consumption reaches 10%. To meet the EU’s targets for reduction of greenhouse gas emissions this share should rise to 30% by 2030 and up to 50% by 2050. The cost of this transition and the necessary measures to guarantee stable and continuous supply are a major political concern. The SABINA project responds to it by targeting the cheapest possible source of flexibility: the existing thermal inertia in buildings and the coupling between heat and electricity networks it enables.
This coupling requires accurately estimating the thermal inertia of many buildings. SABINA’s partner the University of Navarra has created a breakthrough, automatic method for this estimation, which shall be scaled up, validated and integrated in a complete management system through this project. This system will operate on two complementary time horizons:
• One day: aggregation and management at the district level of the electric and thermal flexibilities, and conversion and storage of the excess electrical energy to thermal energy in the freely available building inertia.
• Seconds to minutes: local control of inverters feeding renewable electricity to the grid, with optimal parameters automatically determined at the district level.
Research partners will develop novel control and optimization algorithms, and integrate and evaluate the system in lab and operational settings. The SABINA solution is compatible with both new and existing buildings; it is planned to be deployed within five years of the end of the project. Lead users are present in the consortium: Telvent and SMS plc, the coordinator, for the architecture, and Insero for the business model it enables; compliance and contribution to relevant standards will be ensured by the European Digital SME Alliance | project/european |
W2153575059 | Information Retrieval in Telemedicine: a Comparative Study on Bibliographic Databases | The first step in each systematic review is selection of the most valid database that can provide the highest number of relevant references. This study was carried out to determine the most suitable database for information retrieval in telemedicine field.Cinhal, PubMed, Web of Science and Scopus databases were searched for telemedicine matched with Education, cost benefit and patient satisfaction. After analysis of the obtained results, the accuracy coefficient, sensitivity, uniqueness and overlap of databases were calculated.The studied databases differed in the number of retrieved articles. PubMed was identified as the most suitable database for retrieving information on the selected topics with the accuracy and sensitivity ratios of 50.7% and 61.4% respectively. The uniqueness percent of retrieved articles ranged from 38% for Pubmed to 3.0% for Cinhal. The highest overlap rate (18.6%) was found between PubMed and Web of Science. Less than 1% of articles have been indexed in all searched databases.PubMed is suggested as the most suitable database for starting search in telemedicine and after PubMed, Scopus and Web of Science can retrieve about 90% of the relevant articles. | publication |
W3116735378 | Non-Standard Employment in the BRICS Countries | Non-standardization of employment has become the main trend of the labour markets in the globalized economy. Attempting to enhance the flexibility of employment relations the legislators in BRICS countries are also the part of this trend. The forms of the nonstandard employment are numerous, the present paper concentrates upon the following ones: temporary employment, part-time and multi-party employment relationship. The authors review the experience of four BRICS countries in regulating non-standard forms of employment and determine what were the specific reasons for adopting them in Russia, China, Brazil, and South Africa. The national parts are introduced by the consideration of the international standards of protection of employees working under non-standard contracts. It is argued that even though these four states did not ratify the ILO Convention No. 181 Private Employment Agencies Convention (1997) and only Russia ratified ILO Part-Time Work Convention (No. 175), the ILO approach has influenced the development of national regulations. Though the equal treatment of all workers is lacking in many aspects of employment relations. In the national parts the authors trace the changes in employment law which reflect the pursuit of flexibilization of the labour market and, as in Brazil, the need to formalize employment relations. | publication |
W2770676323 | Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights | Mass spectrometry imaging (MSI) is a powerful tool that enables untargeted investigations into the spatial distribution of molecular species in a variety of samples. It has the capability to image thousands of molecules, such as metabolites, lipids, peptides, proteins, and glycans, in a single experiment without labeling. The combination of information gained from mass spectrometry (MS) and visualization of spatial distributions in thin sample sections makes this a valuable chemical analysis tool useful for biological specimen characterization. After minimal but careful sample preparation, the general setup of an MSI experiment involves defining an (x, y) grid over the surface of the sample, with the grid area chosen by the user. The mass spectrometer then ionizes the molecules on the surface of the sample and collects a mass spectrum at each pixel on the section, with the resulting spatial resolution defined by the pixel size. After collecting the spectra, computational software can be used to select an ... | publication |
W2112492674 | Performance differences and gender in Kiswahili creative writing: a case study of selected secondary schools in Nyamira County, Kenya | This study investigated comparative differences in performance among boys and girls in Kiswahili creative writing in selected secondary sc hools in Kenya . The study was carried out in Nyamira County in Kenya located at a GPS of 0.5210° S, 34.9140° E. Simple random sampling, cluster and systematic sampling techniques were use d to select the students. Ten secondary schools were used in the study and the sample comprised 180 students (on an equal distribution of boys and girls,). The research instrument was a Kiswahili creative writing task. The form 4 students were required to perform a task which invo lved writing an essay in Kiswahili. To reveal the sex differences in Kiswahili creative wr iting, the two-tailed t-test was used. The sex differences were considered significant if they wer e more than the critical value (t-critical: 2.576) at p<.01 based on 178 degrees of freedom. The study revealed that girls outperform boys in overall performance in Kiswahili creative writing, style and spelling conventions whereas the two sexes remained at par in content presentation, vocabulary use and use of grammatical elements in Kiswahili creative writing. In light of the above findings, the researcher generally recommends that students should be provided with remedial teaching to improve their performance in Kiswahili creative writing and a sex unit be established in the department of languages to monitor the progress of boys and girls among other many recommendations. | publication |
176233 | Noisy electromagnetic fields - a technological platform for chip-to-chip communication in the 21st century | Wireless Chip-to-Chip (C2C) communication and wireless links between printed circuit boards operating as Multiple Input Multiple Output devices need to become dominant features of future generations of integrated circuits and chip architectures. They will be able to overcome the information bottleneck due to wired connections and will lead the semiconductor industry into a new More-Than-Moore era. Designing the architecture of these wireless C2C networks is, however, impossible today based on standard engineering design tools. Efficient modelling strategies for describing noisy electromagnetic fields in complex environments are necessary for developing these new chip architectures and wireless interconnectors. Device modelling and chip optimization procedures need to be based on the underlying physics for determining the electromagnetic fields, the noise models and complex interference pattern. In addition, they need to take into account input signals of modern communication systems being modulated, coded, noisy and eventually disturbed by other signals and thus extremely complex.
Recent advances both in electrical engineering and mathematical physics make it possible to deliver the breakthroughs necessary to enable this future emerging wireless C2C technology by creating a revolutionary electromagnetic field simulation toolbox. Increasingly sophisticated physical models of wireless interconnects and associated signal processing strategies and new insight into wave modelling in complex environments based on dynamical systems theory and random matrix theory make it possible to envisage wireless communication on a chip level. This opens up completely new pathways for chip design, for carrier frequency ranges as well as for energy efficiency and miniaturisation, which will shape the electronic consumer market in the 21st century. | project/european |
W654704105 | Iron Age and Middle Saxon Settlements at West Fen Road, Ely, Cambridgeshire: The Consortium Site | The Iron Age and Middle Saxon sites are described and discussed in detail. Both sites consisted mainly of ditched enclosures with sparser numbers of pits and other features. They yielded significant artefactual assemblages and palaeo-environmental and economic material, including some waterlogged and mineralised plant remains for the Middle Saxon period. Comparisons between the periods show a greater emphasis on sheep rearing in the Middle Saxon period than in the Iron Age, and a more varied diet for the inhabitants, including fish and hedgerow fruits. Both periods of occupation are in many respects typical of broader trends. The Iron Age enclosures formed part of an extensive permanent occupation of the Isle of Ely from 400-300 BC, with reorganisation in the 1st century AD. The beginning of Middle Saxon settlement around AD 700 and its contraction around AD 850 can be attributed to the wider fortunes of the monastic centre on the island. | publication |
EP 2015051960 W | FLOW DEVICE AND A METHOD FOR GUIDING A FLUID FLOW | The invention relates to a flow device (50) comprising a first line system (60) through which a first fluid flow (100) is conducted, said first line system (60) having a guide tube (21) and at least one guide means (20, 22) that influences a flow direction of said fluid flow (100) such that, between an inflow region (61b) and an outflow region (62b) of said first line system (60), the fluid flow (100) circulates in a radially circumferential manner around an in and/or outflow axis (102, 103), in a circulating-flow region (105) at a circumferential angle UW. The invention also relates to a method for conducting a fluid flow (10), which comprises an inflow and an outflow section (12, 13) that have a substantially parallel, preferably coaxial, in and outflow axis (14, 15). It is suggested that the fluid flow (10) is deflected by at least one guide means (20) arranged between the inflow section (12) and outflow section (13), in a circulating-flow section (17) and at a circumferential angle UW, so as to radially circulate around said in and outflow axes (14, 15), this circumferential angle UW being greater than 0°. | patent |
172408 | European research area on sustainable animal production systems | This proposal seeks funding under the Horizon 2020 Work Programme 2014-2015 to establish an ERA-NET for joint European research coordination on Sustainable Animal Production (SusAn). The scope for this ERA-NET has been developed under the SCAR Collaborative Working Group on Sustainable Animal Production (CWG-SAP).
Funding organisations from 22 European countries initially seek to support one co-funded call followed by other joint activities including the development of a Common Strategic Research and Innovation Agenda on Sustainable Animal Production.
The animal production sector forms an important part of Europe’s (agricultural) economy and plays an essential role in the provision of Europe`s citizens with high quality animal products. Like other agriculture sectors, animal production faces many challenges from projected increases in global demand for food, climate change, competition for natural resources and economic volatility. The European animal production landscape is very complex, consisting of different species farmed within a wide range of different extensive, semi-intensive and intensive production systems using multiple resources to produce a diverse range of animal products and other services. Partners in this ERA-NET believe, however, that these challenges and complexities can be effectively addressed through joint European research within a framework which supports the three pillars of sustainability - economy, environment and society - and targets opportunities for innovative research spanning all areas of animal production such as health and welfare, feeding and nutrition, reproduction, breeding and genetics, housing, nutrient management and economics. Partners in ERA-NET SusAn endorse scientific excellence and recommend an integrated, interdisciplinary, cross-cutting and multi-actor approach to research and knowledge exchange which reflects the complexity of the research requirements for sustainable European animal production. | project/european |
W1724596140 | Observed effects of sastrugi on CERES top-of-atmosphere clear-sky reflected shortwave flux over Antarctica | [1] Determining the clear-sky top-of-atmosphere (TOA) albedo over snow from space requires knowledge of the bi-directional reflectance distribution function (BRDF), which itself is strongly influenced by the surface roughness of the snow. Sastrugi, a common element of surface roughness on Antarctica, tend to have a preferred azimuth direction, meaning the BRDF depends on the location and time of sampling. In this study we demonstrate that a sastrugi signal is present in the Clouds and the Earth's Radiant Energy System (CERES) reflectance measurements and TOA albedo estimates, leading to a spurious variation in instantaneous albedo as a function of solar azimuth of up to 0.08. By using the difference in flux between oblique and nadir views, we estimate the biases in monthly- and annual-mean 24-hour energy weighted clear-sky reflected TOA fluxes caused by sastrugi over Antarctica. At the grid box level, statistically significant monthly-mean biases of between ±15 Wm−2are found. For the entire Antarctic continent, monthly-mean biases are between 0.2 ± 0.9 Wm−2 to −1.7 ± 1.1 Wm−2 where a negative bias indicates the reflected flux is being underestimated. On an annual basis, the Antarctic bias is between −0.9 ± 1.1 Wm−2 and −1.0 ± 1.1 Wm−2. For the global annual mean clear-sky TOA flux, the bias caused by the presence of sastrugi is insignificant, −0.01 ± 0.02 Wm−2. By examining the anisotropy and the wind direction we infer that the negative TOA flux biases are likely to caused by sastrugi perpendicular to the solar azimuth whereas the positive TOA flux biases are likely to be caused by sastrugi parallel to the solar azimuth. | publication |
W2252285257 | Intercropping of root crops with chilli in charlands of Mymensingh | Adoption of intercropping may increases crop production instead of declining trend of agricultural land in Bangladesh. Thus, a field experiment on intercropping of root crops with chilli was executed at char area of Dori Bhabkhali in Mymensingh district during October 2014 to March 2015 to find out an appropriate intercrop for cultivation with chilli for higher productivity and maximum economic return. The experiment was consisted with five crop combinations viz., sole chilli, chilli + radish, chilli+ carrot, chilli + onion and chilli + garlic. Significantly the highest yield (green chilli) was obtained with sole chilli (10.26 t ha-1). Among the intercropping treatments, the highest chilli yield (10.31 tha-1) was obtained from chilli + garlic which were close to chilli + onion whereas the lowest (7.71 tha-1) was found in chilli + radish combination. Intercropping reduced 3 to 48 % chilli yield but total productivity as expressed by chilli equivalent yield increased by 80-135% over sole chilli due to the contribution of companion crops. The highest chilli equivalent yield (25.01 t ha-1), gross return (1250500 Tk ha-1), gross margin (1133500 Tk ha-1) and marginal benefit cost ratio (8.56) were obtained from chilli + garlic combination. Considering the experimental findings, chilli + garlic might be suitable combination for higher productivity and economic return.Progressive Agriculture 26 (2): 109-114, 2015 | publication |
983223 | Uncovering the role of the irhom2-adam17 interaction in inflammatory signalling | The primary inflammatory cytokine, TNFalpha, is a transmembrane protein that requires cleavage by the metalloprotease ADAM17 for its release. Aberrant release of TNFalpha is a hallmark of cancer, chronic inflammation and autoimmune syndromes. The rising prevalence of these widespread diseases necessitates new approaches to manipulate inflammatory signalling, which is the overarching goal of this proposal. Recent studies demonstrate that iRhoms regulate trafficking, maturation and stability of ADAM17. Without iRhoms, TNFalpha shedding is abolished. The aim of this research is to dissect the transmembrane interaction between iRhom2 and ADAM17, which will support the required information to design the first iRhom inhibitor. Using FRET spectroscopy and ADAM17 activity assays, I will first search for essential residues at the transmembrane interface between iRhom2 and ADAM17. Next, I will use rationally designed helical peptides to competitively inhibit the transmembrane interaction. Last, I will test the effect of any inhibitors I develop in an in-vivo human macrophage model and use it to study the significance of this interaction. This study will provide an important mechanistic understanding of iRhom biology, with an emphasis on their mode of specific transmembrane recognition. Moreover, by developing the first specific iRhom2-ADAM17 complex inhibitor, I will establish iRhom2 and ADAM17 as therapeutically relevant targets to manipulate inflammation. | project/european |
219915 | A database of experimental biomaterials and their biological effect | The advent of material science and manufacturing techniques in the last century has led to the development of thousands of novel biomaterials, with potential to revolutionise health care. However, the vast majority of biomaterial studies do not progress beyond the stages of design and testing, and therefore a substantial amount of scientific data is only available in the form of research publications. To date, there is no database curating the experimental data generated by testing novel biomaterials in vitro and in vivo, representing a loss of a valuable big (experimental) data. In here, we propose an open-access database of experimental tissue scaffolds, indexing design features, cellular and tissue responses, thus creating an exhaustive inventory of experimental scaffolds. Such a dataset would enable scientists to efficiently search and interpret relevant information from past studies across all tissues and models, as well as create computational tools to predict and optimise cell-material interaction. A comprehensive map of research activity and findings should also make it easier to identify areas where data is missing or lacking. A systematic, up-to-date overview of the field will also be a useful tool for science policy making. The novelty of the project lies not only in the concept of curating data from laboratory evaluation of experimental biomaterials (rather than just approved medical implants), but also in attempting to face the methodological challenge of extracting and structuring information from the heterogeneous and vast field of experimental biomaterials. One of the keys of this interdisciplinary project is crowd-sourcing biomaterial scientists, thus engaging their expertise and understanding their needs, in order to create a comprehensive, relevant and useful tool to enhance research in the field. | project/european |
2718534 | Development of full lignin based organic redox flow battery suitable to work in warm environments and heavy multicycle uses. | Redox flow batteries (RFBs) are designed to work up temperature of 40ºC, however, discharging the battery generates heat. A cooling system is required to avoid electrolyte degradation or battery malfunction. Cooling requires energy and reduces the battery global efficiency. Moreover, higher temperatures have advantages: low electrolyte viscosity (less pump energy), better electrolyte diffusion in electrode & increase battery power due to increase electron mobility.
BALIHT project aims to develop a new organic redox flow battery suitable to work up to temperatures of 80ºC, with a self-life similar than current organic ones, but with an energy efficiency 20% higher than current RFB since cooling system is not required, less pump energy & high power.
Redox-active organic molecules with promising prospect in the application of RFBs, benefited from their low cost, vast abundance, and high tunability of both potential and solubility. These organic molecules are more soluble in water, which allows more concentrated electrolyte and increased battery capacity.CMBlu has developed an organic redox flow battery technology that use electrolytes from lignin, thin non-fluorinated membrane, carbon-based electrodes and plastic frames. Lignin is a renewable resource and the largest natural source of aromatic compounds from which efficient electrolytes can be produced.
BALITH concept of organic RFB makes this technology suitable for many applications where the requirements for batteries are more challenging like:
- Smoothing of non-dispatchable renewable power plants (like solar or wind)
- Support for Ancillary services
- High performance electric car recharge points
- Improvement of grid flexibility and stability (at both transmission and distribution level).
- Avoid cooling needs in RFB placed in warm countries (between 40º Latitude North & 40º Latitude South). | project/european |
W1815329339 | On the relational complexity of a finite permutation group | The relational complexity $$\rho (X,G)$$?(X,G) of a finite permutation group is the least k for which the group can be viewed as an automorphism group acting naturally on a homogeneous relational system whose relations are k-ary (an explicit permutation group theoretic version of this definition is also given). In the context of primitive permutation groups, the natural questions are (a) rough estimates, or (preferably) precise values for $$\rho $$? in natural cases; and (b) a rough determination of the primitive permutation groups with $$\rho $$? either very small (bounded) or very large (much larger than the logarithm of the degree). The rough version of (a) is relevant to (b). Our main result is an explicit characterization of the binary ($$\rho =2$$?=2) primitive affine permutation groups. We also compute the precise relational complexity of $${{\mathrm{Alt}}}_n$$Altn acting on k-sets, correcting (Cherlin in Sporadic homogeneous structures. In: The Gelfand Mathematical Seminars, 1996---1999, pp. 15---48, Birkhauser 2000, Example 5). | publication |
224801 | Identification of a metalloproteinase-17-mediated cellular signalling circuit in intestinal regeneration and tumorigenesis | The digestive tract has been assigned important but complex tasks. It provides our body with nutrients and water. It gets rid of pathogens while allowing the commensal flora to thrive, and it quickly repairs injuries caused by the constant mechanical and biological stress. Lgr5+ intestinal stem cells (ISCs) play a crucial role in these processes, but when ISCs are lost due to injury, differentiating cells must ‘de-differentiate’ into ISCs to regain the stem cell pool. The cellular signalling processes that control these repair processes are still largely unknown. Matrix metalloproteinases (MMPs) are enzymes capable of cleaving both matrix and non-matrix proteins. My preliminary data identifies Mmp17 as a crucial regulator of inflammation-induced intestinal regeneration. Notably, Mmp17 is only expressed in a subpopulation of visceral smooth muscle cells, and thus is absent from the epithelium. I hypothesize that Mmp17+ cells provide essential niche factors for repair. In addition, I propose that Mmp17 plays an important role in tumorigenesis. First, I will test the role of Mmp17 in intestinal regeneration after whole-body irradiation. My in vivo studies will be supported by an original ex vivo co-culture model, where I combine organoids and muscle cells. Next, I will test the role of Mmp17 in an established tumorigenesis model. Finally, I will attempt to identify the responsible substrate that mediates these processes, both by unbiased mass spectrometry experiments, and by focusing on likely candidates. This work will reveal a new role for muscle cells in the repair of the intestinal epithelium, and may have important implications for treating inflammation, infections and gastrointestinal cancers. MetalloGutRepair thus combines my expertise in smooth muscle cells with that of the host lab in intestinal disease models, in a research environment where I will reach my immediate goals while developing crucial skills for my long-term career as an independent researcher. | project/european |
W4312641940 | Biografia e trajetória de uma elite judicial | Quem são os profissionais atuantes na temática anticorrupção? A partir de uma base de dados de entrevistas com advogados, juízes e procuradores experientes em casos de corrupção no Brasil desde a redemocratização, aplicamos o método prosopográfico para descrever as dimensões social, educacional e ocupacional do grupo. Nossos resultados mostram que o volume de investimentos em ensino supera o de outras carreiras legais fora da especialidade penal econômica, que as universidades públicas continuam sendo as prediletas dessa elite jurídica, e que passagens pelo exterior são tão frequentes quanto a pós-graduação em escolas locais. Para auxiliar a agenda de pesquisa sobre Direito e Sociedade, bem como Direito e Política, investigamos as diferentes colorações de profissionais ocorridas no banco. | publication |
W159060080 | Overview of End Cretaceous Extinctions☆ | Although the end-Cretaceous extinction event goes by a variety of names in both the technical and popular literature (e.g., Cretaceous–Tertiary (K–T) mass extinction, K–T boundary extinction, Cretaceous–Paleocene (K–Pg) mass extinction, Cretaceous–Palaeogene (K–Pg) extinction), it is most closely associated with the uppermost Cretaceous System/Stage – the Maastrichtian – and, to a lesser extent, the lowermost Palaeogene Epoch/Age – the Danian. As such, any review of effects and causes that may (or may not) have occurred during this episode of Earth history must begin with a review of the stratigraphy of these two intervals, not only because this provides the temporal, environmental, geographic, and tectonic context within which the extinction event must be understood, but also because the study cause–effect associations in Earth history is, by definition, largely a stratigraphic exercise. | publication |
2726685 | Proton transport and proton-coupled transport | Secure, competitive, and sustainable energy production is a major challenge facing human societies. Biomimetic solutions such as the development of new biofuel cells are hampered by our thus far incomplete understanding of proton transfer reactions. The same holds for health threats to humanity: Curing diseases like cancer, obesity, chronic gastritis, gastric and duodenal ulcers, requires to pharmacologically interfere - in their molecular details - with yet unresolved proton transfer reactions.
Here we aim at clarifying the molecular reaction mechanism in the confines of interfacial water layers and proteinaceous cavities with
emphasis on arrangement and mobility of proton relay moieties. Achieving this requires an interdisciplinary, multi-level approach comprising cutting edge technologies like second harmonic imaging, single molecule and time resolved fluorescence microscopy and spectroscopy, advanced calculations of proton transfer, bioengineering of membrane channel and transporter containing systems, synthetic design of biomimetic proton channels, solving protein structures and rational drug design.
PROTON will train 15 PhD students, who will acquire a solid state-of-the-art multidisciplinary scientific training in all kinds of proton migration/reaction systems, covering from basic science to industrial applications, thus preparing them to generate new scientific knowledge of the highest impact. In addition, practical training on transferable skills will increase their employability and qualify them for responsible positions in private and public sectors. Cross-disciplinary strategies and close collaboration with industry will enable them to resolve the molecular details of proton driven processes in all kinds of settings - enabling the improvement of biomimetic applications – up to fuel cells - and to identify lead substances which may serve to pharmacologically interfere with proton transport through membrane channels and transporters. | project/european |
W2800244642 | Urban-Rural Systems in Asia: A Research Agenda | These brief notes outline a research agenda for hybrid urban-rural regions in Asia. It emerges from work being undertaken by the Urban-Rural Systems team at the ETH Zurich’s Future Cities Laboratory in Singapore. All cities have their hinterlands of one kind or another. We are interested in the hinterlands of cities surrounded by tropical, wet-rice agriculture. Such hinterlands are typical of many parts of Asia, and they have very specific ecological, economic and demographic characteristics, which mean they interact with nearby urban centres in distinctive ways. Most notably, wet-rice agriculture supports relatively high population densities with fine-grained plot patterns. When urbanisation processes interact with such areas, the rural does not immediately give way to the urban and instead a hybrid rural-urban typology emerges. Sometimes dubbed desakota landscapes (Indonesian for ‘village’ and ‘city’), they are neither strictly urban nor rural in character, but a mixture of both. | publication |
W2034618239 | Bicycle helmets – A case of risk compensation? | Several studies have shown that bicycle helmets have the potential of reducing injuries from accidents. Yet, no studies have found good evidence of an injury reducing effect in countries that have introduced bicycle helmet legislation. Two of the most promising explanations for why helmet laws do not work as intended are risk compensation and shifts in the cycle population as a response to the law. The present article investigates whether the lack of effect of helmet wearing laws is due to risk compensation mechanisms or population shifts (i.e. discouraging cyclists with the lowest accident risk, and thereby increasing the overall average risk per cyclist). A random sample of 1504 bicycle owners in Norway responded to a questionnaire on among other things helmet use, bicycle equipment use, accident involvement, cycling behaviour and risk perception. Data were analysed by using structural equation model (SEM). The results show that the cyclist population in Norway can be divided into two sub-populations: one speed-happy group that cycle fast and have lots of cycle equipment including helmets, and one traditional kind of cyclist without much equipment, cycling slowly. With all the limitations that have to be placed on a cross sectional study such as this, the results indicate that at least part of the reason why helmet laws do not appear to be beneficial is that they disproportionately discourage the safest cyclists. | publication |
CA 434617 A | ADDITIVE FOR INCLUSION IN A HEAVY OIL RESERVOIR UNDERGOING STEAM INJECTION | "ADDITIVE FOR INCLUSION IN A HEAVY OIL RESERVOIR UNDERGOING STEAM INJECTION" The viscosity of heavy oil may be incrementally reduced over what can be achieved by steam alone, by introducing an aqueous metal salt solution into a reservoir undergoing steam injection. The metal ion is selected from the group consisting of Ti, v, Cr, Mn, Fe, Co, Ni, Cu, Zn, Mo and Al. In a preferred feature CO is also introduced as a second additive, with a further oil viscosity reduction being observed with certain of the metal ions. | patent |
W1557058413 | Abstract 9796: Association of Unrecognized Myocardial Infarctions With Impaired Fasting Glucose in the Multi-Ethnic Study of Atherosclerosis | Background: It has been estimated that approximately 25% of initial myocardial infarctions (MI) are unrecognized (UMI). The prognostic implications of UMI’s have been shown to be as severe as those of symptomatic MI’s. Risk factors for UMI’s are not well understood. Because diabetes mellitus is known to be a risk factor for UMI, it is reasonable to investigate impaired fasting glucose (IFG) as a candidate risk factor. Additionally, it has recently been estimated that up to one-third of all adult Americans have IFG. Methods: The relationship between IFG and UMI was examined in the Multi-Ethnic Study of Atherosclerosis (MESA): a cohort of individuals aged 45 to 84 years without clinical cardiovascular disease. At baseline, participants with normal fasting glucose (NFG; n = 4955) and IFG (n=930) underwent a baseline 12-lead electrocardiogram (ECG). Using Minnesota code, an UMI was identified by the presence of pathological Q waves or minor Q waves with ST-T abnormalities. Crude and adjusted odds ratios (ORs) were calculated. Logistic regression was used to adjust for covariates in 2 models. Model 1 adjusted for age, race, gender, and body mass index. Model 2 adjusted for model 1 + systolic blood pressure, diastolic blood pressure, anti-hypertensive medication use, total cholesterol, HDL cholesterol, lipid-lowering medication use, and cigarette use. Results: The sample was 46% male, 41% white, 26% black, 20% Hispanic, and 12% Asian. There were 72 UMIs identified in the normal fasting glucose (NFG) subjects and 30 UMIs among the IFG subjects. The two corresponding prevalences (1.4% vs. 3.2%) resulted in a crude OR for UMI of 2.26 (95% Confidence Interval (CI): 1.47-3.48; p<0.001). With model 1 adjustments, the OR for UMI in IFG compared with NFG was 1.78 (95% CI: 1.12-2.8; p=0.015). With further adjustments in model 2, this relationship remained significant (OR: 1.63 (95% CI: 1.02-2.56); p=0.041). Conclusion: Unrecognized myocardial infarctions by electrocardiogram are associated with impaired fasting glucose in a population without overt cardiovascular disease. Because of the high prevalence of impaired fasting glucose, the implications of this finding may have ramifications for a large proportion of the adult population. | publication |
W2084309690 | Application of regional frequency analysis to the estimation of extreme storm surges | Traditionally, extreme value theory is applied to single-site series of surge observations in order to estimate the probability of occurrence of extreme events at that particular site. However, single-site analyses give uncertain estimation of extreme quantiles, mainly because of the limited duration of observation periods. In order to reduce this uncertainty, regional frequency analysis (RFA) approaches suggest collecting information not only from a single-site series but also from all (statistically) similar available series of observation. The use of RFA is widely increasing in geosciences, but few applications have been attempted yet for surge estimation. The aim of this study is to examine the applicability of RFA to extreme storm surges. The surge data observed at 18 French harbors, located on the Atlantic coast from the Spanish to Belgian borders, were collected. The series span a period of 30 years, on average, with the longest series going back to the 19th century. Stationary and independent samples of extreme surges (peaks over a given threshold) are extracted and their (statistical) homogeneity has been tested via heterogeneity and discordancy measures based on L moments. Homogeneous regions have been identified and, in order to merge information on frequency of occurrence of surges from all the sites, a surge index pooling method is defined. Finally, a regional frequency distribution has been estimated. The hypothesis and the applicability of RFA application are discussed, with some ideas for future developments in the research direction. | publication |
W1679028378 | The hysteretic evapotranspiration-Vapor pressure deficit relation | Diurnal hysteresis between evapotranspiration (ET) and vapor pressure deficit (VPD) was reported in many ecosystems, but justification for its onset and magnitude remains incomplete with biotic and abiotic factors invoked as possible explanations. To place these explanations within a holistic framework, the occurrence of hysteresis was theoretically assessed along a hierarchy of model systems where both abiotic and biotic components are sequentially added. Lysimeter evaporation (E) measurements and model calculations using the Penman equation were used to investigate the effect of the time lag between net radiation and VPD on the hysteresis in the absence of any biotic effects. Modulations from biotic effects on the ET-VPD hysteresis were then added using soil-plant-atmosphere models of different complexities applied to a grassland ecosystem. The results suggest that the hysteresis magnitude depends on the radiation-VPD lag, while the plant and soil water potentials are both key factors modulating the hysteretic ET-VPD relation as soil moisture declines. In particular, larger hysteresis magnitude is achieved at less negative leaf water potential, root water potential, and soil water potential. While plant hydraulic capacitance affects the leaf water potential-ET relation, it has negligible effects on the ET-VPD hysteresis. Therefore, the genesis and magnitude of the ET-VPD hysteresis are controlled directly by both abiotic factors such as soil water availability, biotic factors (leaf and root water potentials, which in turn depend on soil moisture), and the time lag between radiation and VPD. | publication |
EP 9301983 W | MODULE FOR A SOUND-DAMPING WALL AND A SOUND-DAMPING WALL MADE UP OF MODULES | A module (12) for a sound-damping wall made up of a plurality of modules (12) has hollow chambers (32, 33) between its upper (37) and lower (38) sides. The upper (37) and lower (38) sides are mutually matchingly shaped so that the modules (12) can be stacked. In the novel module (12), the hollow chambers (32, 33) can be filled with sound-damping material (41). | patent |
W1974694013 | Inflammatory bowel diseases and the general practitioner’s role in a region of Central Italy | Inflammatory bowel diseases and the general practitioner’s role in a region of Central Italy Paolo Sossai1,2, Fabio Filippetti3, Ali Ahmad Muselmani4, Giambattista Catalini41Department of Medicine, “Enrico Mattei” Hospital, Viale Europa, I-62024 Matelica, Italy; 2Center of Clinical Research, Department of Experimental Medicine, University of Camerino, Via M Scalzino, 3, I-62032 Camerino, Italy; 3Epidemiological Unit, Marche Region, Via Gentile da Fabriano, 3, I-60125 Ancona, Italy; 4Department of Surgery, General Hospital, Via Caselle, I-62032 Camerino, ItalyBackground: Inflammatory bowel diseases (IBD) are a serious burden for both patients and health care providers because of the young age at which they occur and their chronic course.Aim: The purpose of this study was to assess how general practitioners (GPs) in the area of Camerino-Matelica, Marche (Central Italy) manage their patients with IBD.Materials and methods: Before providing an educational course about IBD to GPs, we administered a simple questionnaire containing 10 multiple-choice questions, allowing for only one possible answer, to GPs in the target area. After the educational course we administered a satisfaction questionnaire and evaluated the hospitalization rates for IBD in the catchment area in the year following the course.Results: In our GP sample, 71.8% indicated that they needed better instruction regarding IBD to enable them to diagnose the conditions given the difficulties posed by nonspecific symptoms and the need to use invasive diagnostic methods such as colonoscopy. Early results after the educational course for GPs indicate a reduced rate of hospitalization for IBD but these data must be confirmed by future research.Conclusions: If specialists and GPs managed IBD patients more carefully, their patients would probably suffer from fewer relapses and would have a better quality of life, which would be likely to mean considerable cost savings for the public health care system and society in general.Keywords: inflammatory bowel disease, Crohn’s disease, ulcerative colitis, general practitioner | publication |
interreg_998 | Data Infrastructure for the Alps: Mountain Orientated Network Technology | Conceived with the steering bodies of the Alpine Convention (AC), DIAMONT aims to give a vital impulse to the relaunch of SOIA (System for Observation of and Information on the Alps). In consistence with SOIA’s new aims and the European Spatial Development Perspective (ESDP), DIAMONT will take into account the expectations of experts for regional development as well as the needs of the Alpine population. The DIAMONT network of specialists on Alpine development will advise SOIA on the elaboration of an Alpine wide information system and the selection of relevant data considering their validity and their aptitude for harmonisation. This process will involve a test of pilot tools for regional development and discussions with the population in test regions. DIAMONT integrates cultural, regional and local factors into the analysis and preparation of a sustainable regional development. The project’s results will supply a method adaptable to other European mountain areas. | project/regional |
W1031146105 | Transformed in Christ, the Master of Uncommon Sense | “I am the way and the truth and the life; no one comes to the Father except through me.” As a sixteen-year-old seminarian in Piedmont, Italy, James Alberione was seized by those words of Christ. He had read Leo XIII’s encyclical for the dawn of the twentieth century, Tametsi futura prospicientibus, On Jesus Christ the Redeemer. He had absorbed the thinking of now-Blessed Giuseppe Toniolo, economist and leader of Christian social thought. Together, they launched Alberione on a unique, lifelong quest into the Person of Christ the Master, both rooted in Christian Tradition and responsive to society. Exactly one hundred years ago, that response took the form of what gradually became the ten branches of the Pauline Family. Each branch, in its own way, bears witness to Christ the Master, Way, Truth, and Life. The theological-spiritual synthesis that undergirds this witness is the principal reason that at Alberione’s beatification, John Paul II would call him “the first apostle of the new evangelization.” What secret does this synthesis hold for us here as we attempt to renew the West? | publication |
US 2010/0054101 W | LOOP ROPE ASSEMBLY | A loop rope assembly includes a main rope segment having a plurality of rope strands and first and second ends, a first end loop provided on the first end of the main rope segment, a second end loop provided on the second end of the main rope segment and at least one intermediate loop defined by at least one of the rope strands. A linkable loop rope system that includes at least two loop rope assemblies fastened together by a coupling mechanism operable to releaseably couple the rope assemblies for use in securing large and/or irregular shaped objects on a transport vehicle or a tarp or cover on such objects during transport. | patent |
US 201715585320 A | METHODS OF PROVIDING THERAPEUTIC EFFECTS USING CYCLOSPORIN COMPONENTS | Methods of treating an eye of a human or animal include administering to an eye of a human or animal a composition in the form of an emulsion including water, a hydrophobic component and a cyclosporin component in a therapeutically effective amount of less than 0.1% by weight of the composition. The weight ratio of the cyclosporin component to the hydrophobic component is less than 0.8. | patent |
W2901045930 | Comparing Industrial Amination Reactions in a Combined Class and Laboratory Green Chemistry Assignment | This article describes a comparative assignment developed for a third-year undergraduate organic synthesis course involving a combined laboratory experiment and class exercise. In this assignment, students compare the sustainability of two industrial amination reactions to form the same target molecule (4-(n-hexylamino)benzonitrile): a nucleophilic aromatic substitution procedure (SNAr) provided in the class exercise, and a Buchwald–Hartwig (B–H) amination procedure completed in the laboratory. The assignment is structured using a “case-study” format to provide appropriate context. Students use industrial solvent and reagent substitution guides, complete process mass intensity calculations, and apply the Twelve Principles of Green Chemistry to compare and contrast the SNAr and B–H reactions. They finally recommend a preferred reaction procedure after considering multiple sustainability concepts in their analyses. The assignment is highly adaptable as different industry guides may be used and the SNAr reac... | publication |
216157 | Time-Programmed self-assemblies and dynamic materials | TimeProSAMAT aims to introduce concepts to program the time domain of self-assembled systems and materials in CLOSED systems under non-equilibrium conditions by controlling the kinetics of assembly and disassembly pathways via (i) modulating the surrounding by feedback systems, (ii) dissipative structure formation and (iii) active structural feedback. After reaching a fundamental understanding on a SA level, we want to capitalize on these enabling SA concepts by providing entirely new and original approaches to dynamic soft materials with internally encoded self-regulation features (similar to a self-destruction mechanism), opening doors to active functionalities and adaptive properties beyond what classical responsive equilibrium SA can offer.
Read more about such concepts in the 10th year anniversary issue of Soft Matter: "" Approaches to program the time domain of self-assemblies"" Soft Matter, 2015,11, 7857-7866 | project/european |
W2012247074 | Electrical double layer capacitor using poly(methyl methacrylate)–C4BO8Li gel polymer electrolyte and carbonaceous material from shells of mata kucing (Dimocarpus longan) fruit | Abstract Poly(methyl methacrylate), PMMA based gel polymer electrolytes (GPE) containing immobilized lithium bis(oxalato)borate, C4BO8Li or LiBOB dissolved in a propylene carbonate–ethylene carbonate binary solvent were prepared by heating the cast solution between 70 and 80 °C for 20 min. The electrolyte composition with 5 wt.% PMMA exhibited the highest conductivity of 3.27 and 7.46 mS cm−1 at 298 and 343 K respectively. Cyclic voltammetry studies on the GPE containing 15 wt.% PMMA and 85 wt.% (0.6 M LiBOB) dissolved in equal weight of ethylene and propylene carbonates showed that the electrochemical potential stability window of the electrolyte lies in the range between −1.7 to +1.7 V. Linear sweep voltammetry indicates the gel polymer electrolyte is stable up to 1.7 V. The electrical double layer capacitor (EDLC) using the highest conducting GPE and activated carbon derived from shells of the mata kucing (Dimocarpus longan) fruit has capacitance of ∼685 mF g−1 on the first cycle. The EDLC performance was also characterized using cyclic voltammetry and charge–discharge processes at constant current. | publication |
Q4429616 | Internazionalizzazione della società "Luxon" sp. z o.o. | Sa 42799(2015/X) L'oggetto del progetto è la partecipazione della Società al programma di promozione del settore "Costruzione e finitura di edifici" al fine di promuovere sui mercati esteri. L'azienda offre prodotti con caratteristiche innovative sul mercato internazionale nel campo dell'illuminazione industriale, grazie ai quali ha le potenzialità per competere efficacemente sul mercato internazionale. Il progetto prevede la partecipazione a 2 missioni in uscita relative ad eventi fieristici e congressuali internazionali in Germania. Si tratta di eventi rinomati con una portata globale, in cui le aziende del settore delle costruzioni si incontrano, così come i potenziali acquirenti di tali soluzioni. L'azienda "Luxon" intende esibirsi come espositore anche a 4 fiere (3x Germania, 1x Emirati Arabi Uniti). È inoltre prevista una missione unica di appaltatori presso l'impianto del richiedente per presentare i prodotti, i metodi di produzione e l'organizzazione. Inoltre, l'azienda svolgerà ulteriori attività promozionali di natura di supporto, finalizzate alla promozione di marchi di prodotto e attività dell'azienda al di fuori del paese (ad es. presentazione di prodotti e aziende e un sito web in lingua straniera). Tutti i materiali prodotti nell'ambito del progetto terranno conto dei principi di visualizzazione del Marchio Economico Polacco. Nella parte non coperta dal cofinanziamento, la Società finanzierà il progetto con i fondi propri generati dalle operazioni correnti, che è consentito dai risultati finanziari della società. | project/regional |
FR 2010051184 W | SYSTEM FOR THE OVERALL CONTROL OF HEAT FOR ELECTRICALLY PROPELLED MOTOR VEHICLE | The invention relates to a system (10) for the overall control of heat for the passenger compartment (33) and for the electrical units in a motor vehicle that is completely or partially propelled by an electric engine powered by a battery, including a heat-control fluid circuit (3) coupled to a heating means (27) and/or to a cooling means (4) enabling said fluid to store calories or frigories when the system (10) is plugged into an electrical network outside of the vehicle. Said fluid circuit is capable of releasing calories and/or frigories to the air of the passenger compartment (33), in an alternating manner, either through a heat exchanger (11c, 11f) between the circuit and the air of the passenger compartment, or using a climate circuit (4) forming a heat pump and/or an air-conditioning system. Reference: figure 3. | patent |
631659 | Fundamental properties and time-scan of qcd matter at high densities and temperature exposed by jet substructure in heavy ion collisions with cms experiment at the lhc | Quantum Chromodynamics (QCD) is the theory of the strong force. Its high-temperature phase can be accessed experimentally via high energy heavy-ion collisions, allowing us to investigate how the macroscopic properties of nuclear matter arise from QCD interactions between quarks and gluons.
With this proposal I aim to solve several fundamental and long-standing questions concerning the strong force and the evolution of the high density phase of QCD, the Quark Gluon plasma (QGP), that are related to the evolution of the early universe:
a) Characterize the transport coefficient, qhat, of the Quark Gluon Plasma, which is related to its density
b) Perform the equivalent of the Rutherford experiment in the QGP, to resolve the point-like quark and gluon scatterers within the QGP.
c) Provide first experimental evidence of two important interference mechanisms that are expected to play a main role in the evolution of jets in a QGP, such as the Landau Pomeranchuk Migdal effect in QCD and the color coherence effect
d) Study the phenomenology of the Lund plane, in particular selections on the branching time obtained from the splitting kinematics. Can it be used to draw a time-dependent picture of the jet shower?
e)Perform the first attempt to time-scan the QGP with a yoctosecond chronometer using hadronic decays of W and Z bosons.
As a world leader in the field of jet physics, also with a strong phenomenological background, I am in a unique position to to solve some of the most interesting problems concerning QCD at high densities by applying new ideas and techniques and exploring the jet substructure.
The CMS detector capabilities for jet and electroweak boson reconstruction and the synergy between the pp and heavy ion communities within, make of CMS the ideal experimental detector to capitalize on my ideas and existing expertise.
This grant will also provide the opportunity to reinforce the european contribution to the CMS heavy ion program and lead it. | project/european |
W2065957910 | THEORETICAL STUDY OF THE S²-P INTERACTION BETWEEN TL(I) AND OLEFINIC SYSTEMS ON HYPOTHETICAL [TL(c2H4)2]+ And [TL(c2H2)n]+ (N = 2,3) COMPLEXES | The attraction between [C2HJ2 and [C2HJ23 and Tl(I) in the hypothetical [Tl(C2H4)2]+ and [Tl(C2H2)n]+ (n = 2,3) complexes was studied using ab initio methods. It was found that the changes around the equilibrium C-Tl distance and in the interaction energies are sensitive to the electron correlation potential. We evaluated these effects using several levels of theory, including HF, MP2, MP4 and CCSD(T). The equilibrium C-Tl distances in the complexes are in the range of 294 pm to 338 pm. The interaction energy differences obtained at the equilibrium distance range from 55 to 110 kJ/mol at the different levels used. These results indicate that the complexes formed are in the category of van der Waals systems. Also, these results indicated that the interaction between olefinic systems and Tl(I) are a real minimum on the potential energy surfaces. | publication |
W4281901150 | Ensino e aprendizagem de conjuntos numéricos a partir de práticas pedagógicas | O presente texto relata uma experiência de prática pedagógica desenvolvida em 2020 com 20 alunos do 9º ano do Ensino Fundamental de uma escola da rede municipal de Poço Redondo (SE), com o intuito de avaliar de forma diagnóstica o objeto do conhecimento que versa sobre os conjuntos dos números naturais, inteiros, racionais, irracionais e reais, estudados por eles em anos anteriores. Para isso, neste texto, são discutidos aspectos sobre prática pedagógica, avaliação e discussões a respeito de materiais didáticos feitas por autores que abordam a temática escrita. A partir do desenvolvimento da atividade matemática, foi possível identificar que a utilização dos materiais didáticos contribuiu para o desenvolvimento da aprendizagem dos alunos por meio de discussões sobre os conjuntos numéricos, realizados em grupos e com toda a turma. A partir dessa execução, foi possível constatar, por meio da avaliação diagnóstica, que os estudantes possuíam dúvidas em relação aos conjuntos numéricos e, com isso, cometiam equívocos na localização dos números em cada parte do diagrama proposto, erros que foram aproveitados para os questionamentos e diálogos desenvolvidos com eles para sanar tais dúvidas. | publication |
220260 | Shape adaptive blades for rotorcraft efficiency | Shape Adaptive Blades for Rotorcraft Efficiency (SABRE) will develop ground-breaking new helicopter blade morphing technologies which will reduce helicopter fuel burn, CO2 and NOx emissions by 5-10%, while also reducing noise emissions. SABRE will help Europe achieve its ambitious aviation emissions goals while also sharpening its competitive edge in the rapidly growing international helicopter market. It will achieve this ambitious objective by removing one of the most fundamental limitations on helicopter performance: the need for rotor blades to have a single fixed geometry which is inherently a compromise between widely different operating conditions. SABRE envisions shape adaptive blades which can continuously change their shape to optimise performance in all conditions. SABRE has a tightly cross-linked, dual stream research approach with emissions-focused rotor performance analysis running concurrently with morphing technology development. The analysis stream will combine comprehensive rotor analysis, high-fidelity aerodynamic and structural solvers, detailed morphing mechanism models, and emissions models, creating the most detailed, transdisciplinary, and comprehensive model of its type. The technology development stream will mature a selected group of novel, beyond state-of-the-art, helicopter focused morphing concepts through a carefully considered program of modelling, design and experimental testing efforts. The achievable performance of the morphing concepts will be fed back into the emissions analysis, and the analysis stream will guide the development of the technologies towards configurations which minimize emissions. SABRE is highly ambitious in both its objectives and its approach. The project has strong industry support, and brings together the ideal consortium to achieve its objectives; with world-leading experts in rotorcraft and morphing structures backed up by a clear project plan, robust management procedures, and excellent facilities. | project/european |
US 202318357994 A | METHOD AND COMPOSITION FOR IMPROVING ADHESION OF METATHESIS COMPOSITIONS TO SUBSTRATES | A method of improving the adhesion of metathesis compositions, such as ring-opening metathesis polymerization (ROMP) compositions, to a substrate is disclosed, in which an adhesion promoter is added to a polymerizable resin composition in order to improve the adhesion of the polymerizing resin to a substrate material. The addition of the adhesion promoter has been found to provide beneficial improvements in the adhesion of metathesis, especially ROMP, compositions to substrates, particularly glass surfaces, leading to improved characteristics in ROMP materials formed therefrom. The adhesion promoter generally comprises a functionalized silane compound and a peroxide compound. A ROMP composition is further disclosed comprising a cyclic olefin, a ROMP metathesis catalyst, and the adhesion promoter. Polymer products produced via metathesis (ROMP) reactions of the invention may be utilized to provide a wide range of materials and in a variety of composite applications. The invention has utility in the fields of catalysis, organic synthesis, and polymer and materials chemistry and manufacture. | patent |
W2563639132 | Covariant gaussian approximation in Ginzburg–Landau model | Condensed matter systems undergoing second order transition away from the critical fluctuation region are usually described sufficiently well by the mean field approximation. The critical fluctuation region, determined by the Ginzburg criterion, $\left \vert T/T_{c}-1\right \vert \ll Gi$, is narrow even in high $T_{c}$ superconductors and has universal features well captured by the renormalization group method. However recent experiments on magnetization, conductivity and Nernst effect suggest that fluctuations effects are large in a wider region both above and below $T_{c}$. In particular some "pseudogap" phenomena and strong renormalization of the mean field critical temperature $T_{mf}$ can be interpreted as strong fluctuations effects that are nonperturbative (cannot be accounted for by "gaussian fluctuations"). The physics in a broader region therefore requires more accurate approach. Self consistent methods are generally "non - conserving" in the sense that the Ward identities are not obeyed. This is especially detrimental in the symmetry broken phase where, for example, Goldstone bosons become massive. Covariant gaussian approximation remedies these problems. The Green's functions obey all the Ward identities and describe the fluctuations much better. The results for the order parameter correlator and magnetic penetration depth of the Ginzburg - Landau model of superconductivity are compared with both Monte Carlo simulations and experiments in high $T_{c}$ cuprates. | publication |
EP 11156023 A | Vehicle body floor structure | Left and right floor frames (15) each have a U sectional shape having an upward opening and is fixedly joined at upper end edge portions (15a, 15b) of the opening to the lower surface of a floor panel (41). Left and right floor frame reinforcing members each extend forward from near a raised floor portion (51) and has an inverted U sectional shape having a downward opening. Each of the reinforcing members is fixed at its lower end edge portions (72, 73) of the downward opening to the upper end edge portions of a corresponding one of the floor frames with the floor panel sandwiched therebetween and with closed sectional shapes defined over and under the floor panel. | patent |
GB 2006003055 W | LADDER SAFETY DEVICES | Ladder safety apparatus comprises a ladder support having a plate (10), with an abutment wall (12) for a ladder foot, a non-slip rubber ribbed ladder engaging surface on its upper side, and a lower surface provided with an array of mini-spikes (17). The plate (10) is adapted to be carried in a case (20), with sidewalls, a rear wall and a lid (22) attached to the rear wall. A front wall (21) is lower than the other walls, so that a part (13) will extend from the case when the case is closed, and provides a carrying handle (14). A fence (25) in the case provides an abutment for the plate when deployed to support a ladder. | patent |
W2316477274 | P16.18 * INTEROBSERVER VARIABILITY IN THE RADIOLOGICAL ASSESSMENT OF PERFUSION MR IMAGING IN GLIOBLASTOMA MULTIFORME | INTRODUCTION: The limitations of conventional MR imaging for accurate tumor assessment and differentiation of true tumor progression and pseudoprogression in glioblastoma multiforme have led to the search for new imaging modalities. The perfusion MRI is a technique that is capable of quantifying microvessel density (vascularity) and permeability of brain tissue by assessment of the relative cerebral blood volume (rCBV), reflecting the degree of microvascular proliferation in tumor tissue. This study is performed to assess the interobserver variability in the radiological assessment of perfusion MR imaging in patients with glioblastoma multiforme treated with temozolomide chemoradiation. METHODS: Three radiologist evaluated the perfusion MRI of 20 patients during treatment with temozolomide chemoradiation at baseline and at 3 months and 6 months after start of treatment. The interobserver agreement is assessed by intraclass correlation coefficients between the radiologists. Results (interobserver agreement results given in ICC's will follow, study is ongoing.) CONCLUSION: The radiological assessment of perfusion MR imaging in patients with glioblastoma multiforme is … | publication |
W2123836760 | Wavefront-guided laser in situ keratomileusis (Lasik) versus wavefront-guided photorefractive keratectomy (Prk): a prospective randomized eye-to-eye comparison (an American Ophthalmological Society thesis). | To compare the safety and efficacy of wavefront-guided laser in situ keratomileusis (LASIK) vs photorefractive keratectomy (PRK) in a prospective randomized clinical trial.A cohort of 68 eyes of 34 patients with -0.75 to -8.13 diopters (D) of myopia (spherical equivalent) were randomized to receive either wavefront-guided PRK or LASIK in the fellow eye using the VISX CustomVue laser. Patients were evaluated at 1 day, 1 week, and months 1, 3, 6, and 12.At 1 month, uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), 5% and 25% contrast sensitivity, induction of higher-order aberrations (HOAs), and subjective symptoms of vision clarity, vision fluctuation, ghosting, and overall self-assessment of vision were worse (P<0.05) in the PRK group. By 3 months, these differences had resolved (P>0.05). At 1 year, mean spherical equivalent was reduced 94% to -0.27 ± 0.31 D in the LASIK group and reduced 96% to -0.17 ± 0.41 D in the PRK group. At 1 year, 91% of eyes were within ±0.50 D and 97 % were within ±1.0 D in the PRK group. At 1 year, 88% of eyes were within ±0.50 D and 97% were within ±1.0 D in the LASIK group. At 1 year, 97% of eyes in the PRK group and 94% of eyes in the LASIK group achieved an UCVA of 20/20 or better (P=0.72). Refractive stability was achieved in both PRK and LASIK groups after 1 month. There were no intraoperative or postoperative flap complications in the LASIK group. There were no instances of corneal haze in the PRK group.Wavefront-guided LASIK and PRK are safe and effective at reducing myopia. At 1 month postoperatively, LASIK demonstrates an advantage over PRK in UCVA, BSCVA, low-contrast acuity, induction of total HOAs, and several subjective symptoms. At postoperative month 3, these differences between PRK and LASIK results had resolved. | publication |
Q2074148 | MONITOR — AN AID TO THE DAILY MANAGEMENT OF RARE DISEASES | The PROJECT MONITOR IS ALTALLY PROVIDED FOR THE MID-TERM OF DELLA WHETHER WITH A person * AFFIED BY MALATTIE CRONICHE, CENTRAL DEPARTMENT OF THE ACTION OF THIS BANDDO. SUFFERING FROM A CHRONIC DISEASE IS A WEIGHT ACCOMPANYING THE PERSON FOR THE WHOLE LIFE. WITH MONITOR WE WANT TO MAKE THIS WEIGHT MORE SUSTAINABLE, MAKING THE PATIENT FEEL THE LEAST, THROUGH AN EFFICIENT AND USER-FRIENDLY SYSTEM THAT SUPPORTS HIM, BUT ALSO TO THOSE WHO FOLLOW HIS TREATMENT. | project/regional |
623178 | Novel scaffolds by mild photochemical rearrangement of reactive enolate and organolithium anions | We propose to develop new photochemical reactions of conjugated anions with lithium counterions (organolithiums and enolates) to construct functionalized, fused heterocyclic frameworks of use in medicinal chemistry development. N-Allyl/N-benzyllithiums tethered to aromatic and heteroaromatic carboxamides will be employed in dearomatizing cyclizations for the construction of partially saturated fused ring systems, generating extended lithium enolates. Irradiation with visible light at low temperature will induce a series of photochemical rearrangements, delivering – in an operationally simple way - structurally demanding unusual products containing various heterocycles and hetero-fused skeletons based on norcaradienes, cycloheptatrienes, and cyclic ketones. Trapping the reactive cyclopropane units of the products with dipolarophiles such alkynes and olefins will extend the method to dearomatized polycycles via a [3+2] cycloaddition strategy. The method will then be extended from enolates to coloured, conjugated organolithiums more generally, promoting an electron from the HOMO (the C–Li bond of metalated carboxamides) to a new higher energy SOMO. This excited state takes the form of an anion-diradical which may be expected to undergo further interesting inter- or intramolecular reactions to furnish biologically relevant structures. | project/european |
173100 | New robotic medical device for autonomous, home-based gait neurorehabilitation and weight-bearing leg exercise, aimed at adults with loss of standing and walking function | The objective of INSPIRO and MADE FOR MOVEMENT with this business innovation project is to introduce a new ICT solution in the market of adult disabled people: DuoTrainer, a robotic system to allow people that cannot walk or stand by their own practise neurorehabilitation training at their homes autonomously.
There are 45 million people in Europe that can benefit from this machine. Only 15-to-30% of people receiving exercise as part of their therapy follow the recommended dosage, and 35% do not perform any exercise at all, because there is no way for adult people to do it by themselves, and they lack motivation to persevere. DuoTrainer will break those barriers, thanks to: a transfer mechanism to get up without external assistance, a training machine to help users move their legs, and a gaming interface that gives them feedback and an enjoyable training environment.
This is a totally new solution, unique in the market. All other devices are bulky, need several people assisting the patient, or are so expensive that cannot be afforded by the patients or their families. This is a lightweight machine, which will be sold at a similar price as basic assistive devices, and can be used at home by the patient at any time. It will improve the patients’ quality of life, and save referrals to tertiary centres and millions of euros to public health care.
DuoTrainer, invented by INSPIRO, will be produced and distributed internationally by MADE FOR MOVEMENT, starting from their current geographic market (20 countries), and extending it to North America and other countries in successive years.
For this we will conduct a feasibility study in Phase 1, in order to improve the final quality of the product, make agreements with suppliers, address regulatory and IPR issues, define our commercialisation strategy, and elaborate a business plan. In Phase 2 we expect to perform a pilot study to demonstrate DuoTrainer in a real environment, and have it ready for commercialisation in Phase 3. | project/european |
W2067198720 | The Role of Social Capital in Citizen Support for Government Action to Reduce Economic Inequality | This article suggests that an important source of political conflict in Latin America and the Caribbean is the disagreement among the citizenry on the role of government in reducing economic inequality, particularly between the very rich and the poor. While the poor clamor for vigorous public policies to reduce economic inequality, the rich show significantly lower support. The findings of this article, however, indicate that social capital, in the form of interpersonal trust, does work as a conciliatory force between haves and have-nots. The results shed light on the importance of cultivating social capital in the region to boost support among the wealthy for public policies that favor the poor, and consequently for creating the political conditions for governments to fight economic inequality and, in turn, political disparities. | publication |
interreg_1516 | Transnational model, strategies and decision support for innovative clusters and business networks towards green growth, focusing on green e-procurement in EE/RES for energy refurbishment of public buildings | Med area faces a transnational challenge due to the number of older public buildings that are energy-inefficient. GRASPINNO provides innovative green procurement solutions for energy savings/efficient refurbishment of public buildings, focusing on smart cities and communities. Its goals: (a) Improve the capacity of Public Authorities (PAs) to manage the energy efficiency of buildings, moving towards nearly zero energy building; (b) Strengthen SMEs to enter the green energy market. Consolidating EU results from ePrior, PEPPOL (CIP), CO-EFFICIENT and GRASP (MED), we validate an integrated framework of strategies, methods, databases and tools at a wide range of MED pilots.
Our results: 1) Public procurement tool to be used by innovative PAs and clusters/networks for implementing green specs/criteria in tenders with green products/services thus increasing their capacity in green growth, particularly eco-innovation. 2) Decision-support tool (LCC) to be used by PAs for evaluating green products/services. 3) Transnational network for Public/Private Partnerships of eco-innovators including mentoring and business angel support for SMEs, and transnational knowledge base. 4) Integrated transnational innovative solutions with practical recommendations to EU decision makers for their effective policy mainstreaming to benefit all MED areas. Replicability, transferability and leverage effect allow us to provide smart/low-cost/sustainable solutions to PAs and SMEs in the whole MED region. | project/regional |
W1620916397 | Factors Predicting Survival in ALS Patients - Data from a Population-Based Registry in Rhineland-Palatinate, Germany | <b><i>Background:</i></b> The possibility to survive with amyotrophic lateral sclerosis (ALS) varies considerably and survival extends from a few months to several years. A number of demographic and clinical factors predicting survival have been described; however, existing data are conflicting. We intended to predict patient survival in a population-based prospective cohort of ALS patients from variables known up to the time of diagnosis. <b><i>Methods:</i></b> Incident ALS patients diagnosed within three consecutive years were enrolled and regularly followed up. Candidate demographic and disease variables were analysed for survival probability using the Kaplan-Meier method. The Cox proportional hazard regression model was used to assess the influence of selected predictor variables on survival prognosis. <b><i>Results:</i></b> In the cohort of 193 patients (mean age 65.8, standard deviation 10.2 years), worse prognosis was independently predicted by older age, male gender, bulbar onset, probable or definite ALS according to El Escorial criteria, shorter interval between symptom onset and diagnosis, lower Functional Rating Scale, diagnosis of frontotemporal dementia, and living without a partner. <b><i>Conclusions:</i></b> Taking into account these predictor variables, an approximate survival prognosis of individual ALS patients at diagnosis seems feasible. | publication |
3744050 | Practical quantum technology education for industry | The onset of the “second quantum revolution” has catapulted quantum technologies from basement laboratories into the commercial sector. This has led to a growing need for an associated quantum-savvy workforce. Not all of these workers need to have formal post-secondary education in physics, as this revolution needs, for example, mechanical engineers and business managers as much as it needs quantum physicists. However, some quantum competence is immeasurably helpful when working within the field of quantum technologies. Therefore, in order to train this population of educated non-quantum-experts, we propose to develop a series of modules tailored to industry needs. These modules will be cost-effective means of rapidly bringing employees up to speed in the relevant aspects of quantum mechanics without the burden of advanced mathematics and time-commitment of traditional schooling.
For the purposes of this project, we will deploy an already developed introductory quantum module online for use in both secondary and tertiary education, free of charge. In parallel with this, we will work closely with our partners in industry to develop a more advanced and focused prototype of a custom module that will then be tested and refined in the corporate setting to meet the particular needs of our partner companies. The results from this project will be used to develop a roadmap for future commercialization that will maximize both the economic benefit (via collaboration with industry partners) and societal benefit (via collaboration with educational institutions) of our unique product. | project/european |
W1974092601 | Sound Generated by Boundary-Layer Flow over Small Steps: Effect of Step Noncompactness | The effect of acoustically non-compact step height on sound generation in a turbulent boundary layer is studied by computing sound with a boundary-element method and comparing its results with those obtained with a compact-step-height assumption. When the ratio of acoustic wavelength to the step height is large, good agreements between the two methods in predicted sound spectra and directivities are found, thus validating the previous compact Green’s function solutions. Discrepancies between the two results become significant with decreasing �/h. For mildly non-compact step heights, the sound directivity for forward steps exhibits asymmetry, with the upstream side maintaining an approximate dipole shape while the rest significantly distorted. Dips in sound spectra and multiple lobes in directivity are observed along with significantly enhanced sound power when �/h is sufficiently small, indicating that edge-scattering becomes the dominant source mechanism. These results indicate that the compact-step-height assumption is generally applicable for underwater applications, where small Mach numbers give large �/h for most frequencies of interest. For air vehicles with large Mach numbers, its applicability is much more limited. | publication |
978483 | Wessex–Armorica: territories, connections and hierarchies | The aim of the WATCH project is to model the organisation of territories, economic and political connections, and social hierarchies promoted and sustained by maritime connections across and around the English Channel during the early Bronze Age (EBA). This study is crucial to understand how communities living in the Channel coastlands became interdependent at a time when trade in tin and copper was strenghtening the foundations for an extensive prehistoric European union. Central to the project is the study of burials within their human, social, and natural environments using Geographical Information System (GIS) analysis. The project is interdisciplinary, rooted in archaeology but borrowing concepts, methods, and data from geography and environmental sciences. This project will enable the fellow to achieve the research and transferable skills, which will allow him to become a mature independent researcher and international expert of the EBA northwestern Europe. The fellow will be able to apply the most up-to-date GIS skillset to different problems in the field of prehistoric archaeology, which will extend an exciting research career. This project offers the opportunity to the fellow to conduct innovative research and transnational mobility while providing benefits for the European Research Area, the Bournemouth University, the supervisor, the partner organisation and the fellow. This project will allow the fellow to develop a research agenda that will lead to a range of research and consultancy projects with European academic and non-academic institutions for the better understanding of EBA societies and cross-Channel relationships, thus enhancing research excellence and addressing recognized research questions in Europe, and beyond. Finally, the fellow aims to offer civil society the demonstration of how and why both sides of the Channel became socially and economically interdependent in the past is relevant to considering the future of our societies. | project/european |
215743 | Innovative network for monte carlo event generators for lhc physics | We propose a European Training Network that will provide a total of 540 ESR-months of training in Monte Carlo event generator physics and techniques, and related applications in experimental particle physics.
Monte Carlo event generators are central to high energy particle physics. They are used by almost all experimental collaborations to plan their experiments and analyze their data, and by theorists to simulate the complex final states of the fundamental interactions that may signal new physics. We will build on the success of our current MCnetITN, by creating a European Training Network incorporating all the authors of current general purpose event generators, with the main purposes of:
(a) training a large section of our user base, using annual schools on the physics and techniques of event generators and short-term studentships of Early Stage Researchers as a conduit for transfer of knowledge to the wider community;
(b) training the next generation of event generator authors through dedicated PhD studentships;
(c) providing broader training in transferable skills through our research, through dedicated training in entrepreneurship and employability and through secondments to non-academic partners.
We will achieve these training objectives both through dedicated activities and through our research activities:
(d) developing the next generation of higher precision event generators and supporting them for use throughout the LHC era and beyond;
(e) playing a central role in the analysis of LHC data and the discovery of new physics there; and
(f) extracting the maximum potential from existing data to constrain the modeling of the higher-energy data from the LHC and future experiments. | project/european |
W2120584735 | Sexual Intercourse and Oral Sex Among Public Middle School Students: Prevalence and Correlates | Early sexual initiation is associated with elevated teenage pregnancy and STD risk, yet little is known about the prevalence and correlates of sexual behavior among young adolescents. Better information is needed to guide interventions to prevent early sexual debut.Data from a 2005 survey of 4,557 sixth-, seventh- and eighth-grade students at 14 urban public schools in Southern California were analyzed using chi-square tests and logistic regression, to identify correlates of oral sex, intercourse and both.Overall, 9% of youth had ever had sexual intercourse, and 8% had had oral sex. Three percent reported having had oral sex only, 4% intercourse only and 5% both. Among those who reported intercourse, 69% had used a condom at last intercourse, and 43% had had multiple partners. Being male, being black and having at least one friend who had ever been involved in a pregnancy were positively associated with having had intercourse only and both intercourse and oral sex (odds ratios, 1.7-4.2). Being in eighth grade, expecting to have intercourse in the next six months and currently having a boyfriend or girlfriend were positively associated with all three outcomes (2.1-7.2). Intercourse and oral sex were highly correlated.Interventions addressing oral sex, intercourse and multiple partners should begin before sixth grade and continue throughout the middle school years. Health professionals should target adolescent risk reduction counseling toward males, blacks, youth with a boyfriend or girlfriend, and those with a friend who has been involved in a pregnancy. | publication |
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