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644630 | The effects of urbanization on insect diversity and human-nature interactions | Urbanization, one of the most extreme human-induced landscape changes on Earth, yields an important trade-off between development and biodiversity conservation. Recent research highlights the relevance of considering urban landscape organization (land-sharing or land-sparing development) to advance in this debate. However, there are still few studies on the topic, mostly local, on low diversity areas or focused on few taxonomic groups preventing generalization of results. The lack of research on urban insect diversity is remarkable despite their high economic, social and ecological importance. Human-nature interactions also play a critical role in the debate on how to create nature-friendlier and healthier cities, particularly regarding urban landscape organization. This interdisciplinary project aims to provide novel and useful information to this debate by (1) studying the impact of urbanization on multiple components of insect diversity (taxonomic and phylogenetic) in an understudied hotspot (Mediterranean region); (2) exploring if land-sharing or sparing urban areas hold different insect diversity levels; and (3) investigating the influence of urban landscape organization on subjective wellbeing and extinction of experience, critical for human-nature interactions. A complete methodological approach including classic taxonomic procedures, modern metabarcoding tools, and a solid study design combining spatial, temporal and taxonomic replicates grant the generalization of findings. Furthermore, through the use of innovative machine learning techniques, this project will also provide a useful open-access tool for researchers, city planners and citizens that will predict insect diversity and human-nature interactions in non-sampled urban areas. To do so, I will be trained by world experts in the analytical and applied aspects of this highly integrative project (Urban Ecology, Genetics, Sociology, and Computer Sciences), helping me to become an independent researcher | project/european |
W2008288055 | Robust decentralized multi-model adaptive template tracking | In this paper, a robust and efficient visual tracking method through the fusion of several distributed adaptive templates is proposed. It is assumed that the target object is initially localized either manually or by an object detector at the first frame. The object region is then partitioned into several non-overlapping subregions. The new location of each subregion is found by an EM-like gradient-based optimization algorithm. The proposed localization algorithm is capable of simultaneously optimizing several possible solutions in a probabilistic framework. Each possible solution is an initializing point for the optimization algorithm which improves the accuracy and reliability of the proposed gradient-based localization method to the local extrema. Moreover, each subregion is defined by two adaptive templates named immediate and delayed templates to solve the ''drift'' problem. The immediate template is updated by short-term appearance changes whereas the delayed template models the long-term appearance variations. Therefore, the combination of short-term and long-term appearance modeling can solve the template tracking drift problem. At each tracking step, the new location of an object is estimated by fusing the tracking result of each subregion. This fusion method is based on the local and global properties of the object motion to increase the robustness of the proposed tracking method against outliers, shape variations, and scale changes. The accuracy and robustness of the proposed tracking method is verified by several experimental results. The results also show the superior efficiency of the proposed method by comparing it to several state-of-the-art trackers as well as the manually labeled ''ground truth'' data. | publication |
US 200913120781 A | DOCKING STATION WITH ROTATION MECHANISM | A docking station for a portable electronic device is provided. The docking station comprises (a) an engagement element, wherein the engagement element is capable of engaging the said portable electronic device; and (b) a rotation mechanism, wherein the rotation mechanism is capable of rotating said portable electronic device relative to a support base of said docking station. | patent |
W1820083761 | Thymus and Parathyroid Organogenesis | Abstract The thymus is the principal site of T cell development and therefore is of central importance within the immune system: congenital athymia results in profound immunodeficiency, while perturbed thymic function can lead to autoimmunity. Although highly active in early life, the thymus undergoes premature involution, such that de novo T cell development diminishes significantly with age. This has implications for immune function in the aging population, and in clinical procedures such as bone marrow and solid organ transplantation, where thymic function is required for T cell reconstitution and/or tolerance induction. Interest therefore exists in enhancing immune reconstitution through regenerative or cell therapies for boosting thymus activity in vivo, or providing customized in vitro generated T cell repertoires for adoptive transfer. The success of such strategies is likely to depend on a detailed knowledge of the mechanisms regulating thymus development and homeostasis. Here, we review current understanding of cellular and molecular regulation of thymus organogenesis, focusing on the epithelial component of the thymic stroma which provides many of the specialist functions required to mediate T cell differentiation and T cell repertoire selection. | publication |
170112 | Flutter free flight envelope expansion for economical performance improvement | The FLEXOP project is about developing multidisciplinary aircraft design capabilities for Europe that will increase competitiveness with emerging markets -particularly in terms of aircraft development costs. A closer coupling of wing aeroelasticity and flight control systems in the design process opens new opportunities to explore previously unviable designs. Common methods and tools across the disciplines also provide a way to rapidly adapt existing designs into derivative aircraft, at a reduced technological risk (e.g. using control to solve a flutter problem discovered during development). The goal will be achieved by: (a) improving efficiency of currently existing wing, by increased span at no excess structural weight, while establishing modifications by aeroelastic tailoring to carry the redesigned derivative wing; (b) developing methods and tools for very accurate flutter modeling and flutter control synthesis, to enable improved flutter management during development, certification, and operation, enabling to fly with the stretched wing at same airspeed as the baseline aircraft; (c) validating the accuracy of developed tools and methods on an affordable experimental platform, followed by a scale-up study, demonstrating the interdisciplinary development cycle. Manufacturers will gain cost efficient methods, tools and demonstrators for enhancing aircraft performance by integrated development of flutter control and aeroelastic tailoring. These inter-disciplinary capabilities will improve the design cycle and the Verification& Validation process of both derivative and new aircraft. Better control of development and certification costs can be achieved if these capabilities are used to address problems early in the design process. Flight test data will be posted on the project website to provide a benchmark for the EU aerospace community. The project’s results will serve as a preliminary outlining of certification standards for future EU flexible transport aircraft. | project/european |
interreg_3229 | Guidelines for the sustainable treatment of dredged sediments in the Marittimo area | The amplification of the silting phenomena linked to climate change and the presence of pollutants mainly of anthropic origin fixed on the sediments make it necessary to organise their management and integrate risk control. The costs of treating and managing non-submersible sediments weaken or endanger the economic activity and competitiveness of ports. Moreover, the scientific data needed to come up with a normative framework for the management of sediments on the ground are partial, scarce and often inaccessible. Responses must be provided, as sediments present in ports, rivers and canals can have a lasting impact on ecosystems and ultimately on people's health. Hence, the need to implement jointly controlled and economically acceptable operational solutions within the Italy-France Maritime area. As part of the Europe 2020 strategy objectives, the project promotes the production of eco-materials deriving from the management of sediments. SEDITERRA proposes mainstreaming the structured management of a new public waste: sediment. The living lab inspired goal is to share experiences and rely on the results of local solutions that have been able to provide partial answers to a global problem. The application and monitoring of pilot operations on the Maritime region, with sediments from partner ports, will produce data and information widely disseminated during interviews open to all, which will be summarised and published online at www.cap-sediments. SEDITERRA aims to expand a capitalisation process through an exchange of good practices and cross-border emergency participation in a regulatory framework adapted to the land-based handling of sediments. | project/regional |
W1488566356 | Coordinated active steering and four-wheel independently driving/braking control with control allocation | This paper presents a hierarchical coordinated control algorithm for integrating active front steering and four-wheel independently driving/braking control. In the higher-level controller, an adaptive siding mode control law and a coordination law for adjusting the yaw rate and slip angle control priorities are applied to determine the desired front wheel steering angle and external yaw moment. In the lower-level controller, a control allocation algorithm with actuators and tire forces constraint considerations is designed to assign the desired yaw moment to the front wheel steering system and four wheels. The weighting factors of tracking errors and control inputs in the cost function are online updated according to the vehicle stability index. Simulation results with a high-fidelity, CarSim, full-vehicle model show that handling and stability of the vehicle can be improved with the proposed controller. What is more, control of sideslip angle can be more focused when the vehicle is hitting the manoeuvring limitation. | publication |
W2791540735 | Benzimidazole Ring System as a Privileged Template for Anticancer Agents | Cancer still remains a continued threat for human race in the 21st century. It is the major cause of human casualties globally and is thus, a hot topic of research in medicinal laboratories. Scientists are striving to find selective anticancer agents having low toxicity for normal human cells. Heterocyclic ring systems play key role as templates/pharmacophores for various drugs, and benzimidazole ring is especially important for its anticancer derivatives. In this review article, we have focused on the structural features of anticancer derivatives based on benzimidazole ring system. It highlights various benzimidazole-based anticancer compounds which have been developed in recent years. | publication |
W2559817998 | Initiation of Deep Convection over an Idealized Mesoscale Convergence Line | Abstract This study performs cloud-resolving simulations of cumulus convection over an idealized surface-based convergence zone to investigate the mechanisms and sensitivities of deep convection initiation forced by mesoscale ascent. The surface convergence forms in response to a localized diurnal heating anomaly over an otherwise homogeneous and unheated surface, producing a strong boundary layer updraft over the center of the heat source. This updraft gives rise to a line of cumuli that gradually deepen and, in some cases, transition into deep convection. To statistically investigate the factors controlling this transition, a new thermal-tracking algorithm is developed to follow incipient cumulus cores as they ascend through the troposphere. This tool is used to isolate the impacts of key environmental parameters (cloud-layer lapse rate, midlevel humidity, etc.) and initial core parameters near cloud base (horizontal area, vertical velocity, etc.) on the ultimate cloud-top height. In general, the initial core size determines which thermals in a given cloud field will undergo the deepest ascent, and the sensitivity of cloud depth to initial core parameters increases in environments that are more hostile to deep convection. Diurnal midlevel moistening from detraining cumuli above the convergence line produces a small but robust enhancement in cloud-top height, particularly for smaller cores. | publication |
W1972616040 | The preparation, germination properties and stability of superdormant spores of<i>Bacillus cereus</i> | To determine yields, germination and stability of superdormant Bacillus cereus spores.Superdormant B. cereus spores were isolated by germination with high concentrations of inosine or L-alanine in 2-5% yield and did not germinate with high concentrations of either of these germinants, but germinated like starting spores with Ca-DPA, dodecylamine, L-alanine plus inosine or concentrated complete medium. Yields of superdormant spores from germinations with low inosine concentrations were higher, and these spores germinated poorly with low inosine, but relatively normally with high inosine. Yields of superdormant spores were also higher when nonheat-activated spores were germinated. Superdormant spores stored at 4 degrees C slowly recovered some germination capacity, but recovery was slowed significantly at -20 degrees C and -80 degrees C.Factors that influence levels of superdormant B. cereus spores and the properties of such spores are similar to those in B. megaterium and B. subtilis, suggesting there are common mechanisms involved in superdormancy of Bacillus spores.Superdormant spores are a major concern in the food industry, because the presence of such spores precludes decontamination strategies based on triggering spore germination followed by mild killing treatments. Studies of the properties of superdormant spores may suggest ways to eliminate them. | publication |
W2795207416 | Sublimation, Place of the Satisfaction of Repetition in Whirling Movement | We will attempt to show why, according to Lacan, sublimation as the destiny of the non-repressed sexual drive, is the place of satisfaction of repetition. This enables us, amongst other things to straighten out certain confusions linked, after Freud, to handling the notion of sublimation, often confused with idealization. We will illustrate this through the whirling movement of sublimation, in which Lacan’s Homage to Marguerite Duras on the Ravishing of Lol V. Stein finds its place. This is also the opportunity to envisage how “making a case of the clinic” (“faire cas de la clinique”) can be included in this questioning. | publication |
W4286378841 | Exploring the Nature of Dynamic Capabilities and Enabling Environments for Service Innovation in the Global South: The Case of Digital Agro-advisory Services in Burkina Faso | Distribution électronique Cairn.info pour De | publication |
AU 1950/002014 W | A METHOD FOR IDENTIFICATION AND DEVELOPMENT OF THERAPEUTIC AGENTS | The present invention relates generally to the field of identification and determination of bioactive amino acid sequences. In particular, the present invention provides method(s) for determining the influence of variation in host genes on selection of microorganisms with particular amino acid variants for the purpose of therapeutic drug or vaccine design or individualisation of such treatment. The invention also provides methods for identifying HLA allele-specific microorganism sequence polymorphisms that result from HLA restriction of antigen-specific cellular immune responses. It also provides diagnostic and therapeutic methodologies that may be used to measure or treat infection by a microorganism or to prevent infection by the microorganism. | patent |
Q2689038 | Promotion of MAXFRUT Sp. z o.o. on foreign markets through participation in the “Polish Food Specialities” promotion programme | SA 42799(2015/X) The object of the project is to support MAXFRUT Sp. z o.o. in the field of brand promotion on foreign markets through the participation of the Applicant in the promotion programme dedicated to the food industry. As part of the project, the Applicant will participate as an exhibitor in 3 trade fairs: — BioFach/Germany – Sial China/China – Sial Paris/France and will organise economic missions to the following forward-looking markets: THE UNITED STATES. In addition, the project plans economic missions to European countries such as France, Germany and Spain. Research conducted by Pentor shows that fair events are one of the most effective marketing tools. Trade fairs, exhibitions and exhibitions are among the most popular industry events. Despite the progress of technology and the development of means of communication, in particular information technology, the fair remains a key and most effective form of attracting foreign counterparties and developing business, due to the possibility of establishing direct contacts with foreign current and potential customers and checking foreign competition, as well as conducting a direct review of the current offer, which cannot be replaced by virtual contacts. Thanks to the implementation of the project, the company will promote its brand on foreign markets and acquire new contractors, which in effect will allow for an increase in the export activity and export value of the Applicant. Participation in fair events will also make it possible to establish direct relations with existing and potential contractors, which will allow us to gain knowledge about their needs and expectations. The acquired knowledge will allow to adapt the commercial offer to the requirements of foreign customers, and thus to further internationalise the Company’s business. The implementation of the project will be financed from the Company’s own resources. | project/regional |
W1573159449 | Concurrent Deep–Superficial Dyspareunia: Prevalence, Associations, and Outcomes in a Multidisciplinary Vulvodynia Program | Little is known about women with concurrent diagnoses of deep dyspareunia and superficial dyspareunia.The aim of this study was to determine the prevalence, associations, and outcome of women with concurrent deep-superficial dyspareunia.This is a prospective study of a multidisciplinary vulvodynia program (n = 150; mean age 28.7 ± 6.4 years). Women with superficial dyspareunia due to provoked vestibulodynia were divided into two groups: those also having deep dyspareunia (i.e., concurrent deep-superficial dyspareunia) and those with only superficial dyspareunia due to provoked vestibulodynia. Demographics, dyspareunia-related factors, other pain conditions, and psychological variables at pretreatment were tested for an association with concurrent deep-superficial dyspareunia. Outcome in both groups was assessed to 6 months posttreatment.Level of dyspareunia pain (0-10) and Female Sexual Distress Scale were the main outcome measures.The prevalence of concurrent deep-superficial dyspareunia was 44% (66/150) among women with superficial dyspareunia due to provoked vestibulodynia. At pretreatment, on multiple logistic regression, concurrent deep-superficial dyspareunia was independently associated with a higher level of dyspareunia pain (odds ratio [OR] = 1.19 [1.01-1.39], P = 0.030), diagnosis of endometriosis (OR = 4.30 [1.16-15.90], P = 0.022), history of bladder problems (OR = 3.84 [1.37-10.76], P = 0.008), and more depression symptoms (OR = 1.07 [1.02-1.12], P = 0.007), with no difference in the Female Sexual Distress Scale. At 6 months posttreatment, women with concurrent deep-superficial dyspareunia improved in the level of dyspareunia pain and in the Female Sexual Distress Scale to the same degree as women with only superficial dyspareunia due to provoked vestibulodynia.Concurrent deep-superficial dyspareunia is reported by almost half of women in a multidisciplinary vulvodynia program. In women with provoked vestibulodynia, concurrent deep-superficial dyspareunia may be related to endometriosis or interstitial cystitis, and is associated with depression and more severe dyspareunia symptoms. Standardized multidisciplinary care is effective for women with concurrent dyspareunia. | publication |
W2346775371 | Seeing Green: The Use and Abuse of American Environmental Images. By Finis Dunaway. | Seeing Green: The Use and Abuse of American Environmental Images . By Finis Dunaway. (Chicago: University of Chicago Press, 2015. viii + 337 pp. Illustrations, notes, bibliographical notes, index. $40.00, £28.00.)
While a picture may be worth a thousand words, it is often what is not pictured that matters in Finis Dunaway’s excellent Seeing Green . Dunaway analyzes dozens of what he calls “icons of American environmentalism” to assess their impact on the movement and to identify what is missing from them, showing how these visual omissions have hobbled the environmentalist cause. While “media images have made the environmental crisis visible to a mass public,” argues Dunaway, “they often have masked systemic causes and ignored structural inequalities” (p. 2).
Each of Seeing Green ’s fifteen concise chapters analyzes a familiar image or type … maher{at}njit.edu | publication |
216623 | Transforming transport | Big Data will have a profound economic and societal impact in the mobility and logistics sector, which is one of the most-used industries in the world contributing to approximately 15% of GDP. Big Data is expected to lead to 500 billion USD in value worldwide in the form of time and fuel savings, and savings of 380 megatons CO2 in mobility and logistics. With freight transport activities projected to increase by 40% in 2030, transforming the current mobility and logistics processes to become significantly more efficient, will have a profound impact. A 10% efficiency improvement may lead to EU cost savings of 100 BEUR. Despite these promises, interestingly only 19 % of EU mobility and logistics companies employ Big Data solutions as part of value creation and business processes.
The TransformingTransport project will demonstrate, in a realistic, measurable, and replicable way the transformations that Big Data will bring to the mobility and logistics market. To this end, TransformingTransport, validates the technical and economic viability of Big Data to reshape transport processes and services to significantly increase operational efficiency, deliver improved customer experience, and foster new business models. TransformingTransport will address seven pilot domains of major importance for the mobility and logistics sector in Europe: (1) Smart High-ways, (2) Sustainable Vehicle Fleets, (3) Proactive Rail Infrastructures, (4) Ports as Intelligent Logistics Hubs, (5) Efficient Air Transport, (6) Multi-modal Urban Mobility, (7) Dynamic Supply Chains. The TransformingTransport consortium combines knowledge and solutions of major European ICT and Big Data technology providers together with the competence and experience of key European industry players in the mobility and logistics domain. | project/european |
US 77397196 A | Emergency-reporting system for rescue operations | A personal emergency-reporting system for recognizing the site of an emergency with simultaneous warning of the nearest emergency physician/medical personnel. A portable patient data unit is provided which contains a satellite-supported global positioning system, which communicates with a patient data acquisition and evaluation unit via a computer and control unit, wherein the latter is connected to an emergency call transmitter. The transmitter sends patient data and the patient's position to an emergency call receiver in the case of an emergency. An automatic emergency-reporting system is provided by the present invention in order to make possible a rapid and specific rescue operation to a person whose health is acutely at risk. | patent |
W2168741068 | Unpacking Coordination Benefits in Supply Networks: Findings from Manufacturing SMEs | This paper examines how coordination among firms in supply networks generates benefits in the short and long terms for firms. It focuses on information technology (IT) and process improvement coordination. Analysis was performed on quantitative and qualitative data from a sample of SMEs in plastics manufacturing in Pennsylvania. Results indicate that coordination on both IT and process improvement leads to short- and long-term benefits. These relationships were mediated by the adoption of innovations (when coordinating on IT) and access to new capabilities (in process improvement coordination). These results extend the understanding of how participation in supply networks benefits individual firms. | publication |
173922 | Improving the innovation management capacities of smes | The InnovImp proposal is designed to provide in-depth innovation management support services to SMEs based in the Maltese Islands due to an absence of such affordable assistance in the market. The proposal also outlines how beneficiaries of the H2020 SME Instrument will receive specific support by the Enterprise Europe Network through the supported coaching assignments addressing innovation weaknesses. The service portfolio outlined in the InnovImp proposal being funded under H2020, totally complements the other actions being funded under the COSME programme and the proposal ensures that the right synergies will be created to result in the desired impact particularly by removing the innovation management inefficiencies of the client SME. For instance, whereas under COSME new innovation opportunities through partnering may arise, the new services funded under this H2020 call shall enhance the innovation management performance of the enterprise. In this way making their innovation processes more effective and efficient or, specifically for the beneficiaries of SME instrument identifies barriers to might hinder the SME to realise economic impact from its supported project.
InnovImp foresees the use of dedicated assessment tools to gauge gaps and weaknesses in the client's innovation process, and these will be based on the latest CEN definition of an innovation management system.
The InnovImp proposal supports and endorses the objectives outlined in the Competitiveness of Small and Medium Sized Enterprises [COSME] and Horizon2020 [H2020] programmes which both anticipate new and enhanced support mechanisms to help European SMEs. Moreover the delivery of such services through the only Enterprise Europe Network in the Maltese Islands strengthens the relevance of this work programme since the Malta Network enjoys both an embedded position in the local advisory eco-system and significant proximity to the targeted client base. | project/european |
W2473308289 | Reversible Increase of Central Choroidal Thickness During High-Altitude Exposure | This study aimed to quantify the impact of high altitude on choroidal thickness and relate changes of altered choroidal blood flow to clinical parameters and acute mountain sickness (AMS). This work is related to the Tübingen High Altitude Ophthalmology (THAO) study.Enhanced depth imaging spectral-domain optical coherence tomography was used to quantify macular choroidal layer thickness. Peripheral oxygen saturation, heart rate, and AMS scores were assessed in eight healthy subjects at baseline (altitude, 341 m) and at altitude (4559 m) for respective correlations.Longitudinal analysis revealed a significant (P = 0.011, ANOVA) increase in central choroidal thickness (CCT) during altitude exposure (CCT baseline = 271 ± 9 μm; CCT altitude = 288 ± 9 μm) due to an increased choroidal blood flow. Incidence of AMS at altitude was 50%, peripheral oxygen saturation decreased by 25%, and heart rate increased by 39%. All changes were completely reversible after descent to low altitudes.A small but significant increase in choroidal thickness was observed upon acute altitude exposure to 4559 m. This increase in choroidal blood flow was not related to AMS and was fully reversible after return to low altitude. | publication |
3740733 | Flow on thin fluid sheets | Physical phenomena that combine effects on a surface and that in the bulk occur in many fields, ranging from crystal growth in chemistry and proton diffusion in biomembranes, through tyre aquaplaning and self-cleaning materials. We consider this multi-scale problem specifically for coupled bulk-surface fluid flow. Simulating these problems with traditional fluid solvers is challenging because of the different scale of the surface phenomena versus that in the bulk. Towards this end, specialized thin film flow models have been developed to accurately capture surface-level flow effects. However, it remains impossible to automatically detect the formation of thin fluid sheets and resolve the bulk/sheet coupled flow. This limits the application of thin film models. Advances made in thin film modelling have not been applied to complex flow situations where, for example, a free flowing bulk fluid can form thin films over an obstacle, or where sufficient fluid collects on a moving thin fluid sheet to obtain bulk flow. Such problems rely on bulk flow simulations with significantly finer resolutions to capture the surface-level effects, which dramatically increases computation time making full dynamic simulations unrealistic for actual applications.
The primary objective of this project is to model bulk/surface flow phenomena numerically. We will propose novel mathematical models to computationally simulate flow of thin fluid sheets on moving curved surfaces, which can predict not just the evolution of an existing film, but also their formation, collapse and break up. We will develop efficient methods to two-way couple film flow with bulk fluid flow which are able to identify regions where surface level effects are relevant, on the fly. This fellowship will build on the expertise in fluid flow and particle methods of the researcher, and that in multi scale modeling, free boundary problems and advanced discretisation adaptivity of the host. | project/european |
Q2698435 | Soutien à la maintenance et au développement de l’installation «Willa Elżbieta» dans la société Karpacz Emilia Borowy | Emilia Borowy a reçu les revenus suivants: Janvier 2020-52262,79zł Février 2020-43351,50zł Mars 2020-3091,78zł Avril 2020-40,65zł Mai 2020-8589,57zł Les fonds obtenus dans le cadre du projet permettront l’achat de biens commerciaux et de biens et services publicitaires. Ils contribueront également à enrichir l’équipement des salles, ce qui est attendu et bien vu en période de risque élevé d’infection par la COVID-19 (par exemple, bouilloires, ventilateurs, mesures d’hygiène supplémentaires, etc.) ainsi que la rémunération des travailleurs saisonniers. L’entreprise peut se vanter d’une très bonne réputation parmi ses clients et les fonds reçus pourraient aider à améliorer la qualité de l’équipement des chambres et de la salle à manger. De plus, grâce aux fonds reçus, nous prévoyons d’améliorer la qualité de la sécurité dans nos installations en installant d’autres capteurs de fumée, de gaz et de gaz. | project/regional |
IL 2012000239 W | CARBON FILTER DEVICE AND AIR FILTER APPARATUS | An air filter apparatus may include a carbon filter device comprising an air-pervious pouch filled with granular carbon, condensed between two opposite air-pervious limiters and surrounded by an elastic band exerting a force towards a central axis of the carbon filter device so as to maintain the granular carbon tightly packed, allowing air driven through the granular carbon to be filtered. | patent |
Q13245 | Adquisición de tecnologías para la modernización de la producción Ing. Jan Kotrba | El objeto del proyecto es la adquisición de una línea de producción de aserraderos. Parte de esta línea de producción son cintas transportadoras y cadenas, sierra de acortamiento, sierra de banda, sierra de yeso, sierra de molienda y trituradora. El objetivo del proyecto es ampliar la producción con tecnologías de vanguardia que cumplan con todos los requisitos de la más alta calidad. El motivo de la adquisición es introducir tecnología moderna para la producción de madera conífera y caduca, en particular madera de carpintería, madera para construcción, traviesas ferroviarias y madera para palets. | project/regional |
EP 2005000051 W | TWIN CLUTCH TRANSMISSION FOR A MOTOR VEHICLE | The invention relates to a twin clutch transmission (1) for a motor vehicle. This twin clutch transmission (1) has two input shafts (2, 3), two clutches (K1, K2) and at least one first and one second driving shaft (4, 5). The first input shaft (2) can be actively connected to the first clutch (K1), and the second input shaft (3) can be actively connected to the second clutch (K2). The first driving shaft (4) is situated underneath the input shafts (2, 3) and the second driving shaft (5) is situated above the input shafts (2, 3) (or reversed). The input shafts (2, 3) and driving shafts (4, 5) comprise intermeshing gear wheels, and at least two gear wheels (Z1 to Z18) form a gear step. At least one gear wheel of a gear step is provided in the form of an engageable and/or disengageable idler gear, and the other gear wheel is preferably provided in the form of a fixed gear. Each driving shaft (4, 5) has a driving gear wheel (19, 20) for transferring rotatory force to the axle drive (21). Another shaft is provided for realizing the reverse gear RG. The aim of the invention is to realize a versatile highly designed and compact transmission. To this end, the additional shaft is provided in the form of a third driving shaft (22), this third driving shaft (22) has a drive gear wheel (23) for transferring rotatory force to the axle drive (21), and the drive gear wheels (19, 20, 23) of the driving shafts (4, 5) engage with an axle drive gear (21a) of the axle drive (21). | patent |
W2064976627 | Social spending targets in IMF concessional lending: US domestic politics and the institutional foundations of rapid operational change | AbstractThis paper contributes to the literature on the mechanics of change in global economic governance. By synthesising an empirically driven case study with conceptual insights from the existing literature, I highlight three intervening variables that enabled the Legislative Mandates passed by the US Congress in 2009 on the use of social-spending targets (education and health expenditure ring fences) in IMF concessional lending to be rapidly translated into operational change. The intervening variables that stood between US domestic action and rapid operational change are: first, the existence of effective enforcement mechanisms to ensure compliance from the US Executive Director with the Mandate; second, preference congruence between other primary principals and the content of the Mandate, and; third, the existence of effective enforcement mechanisms to ensure compliance from IMF staff with the principals’ collectively-sanctioned goal. The outcome observed – the near universal incorporation of social... | publication |
W1991566039 | Russian Fiscal Federalism under Stress: Federal Support of Regions during the Global Financial Crisis | A former high-ranking Russian Ministry of Finance official examines the consequences of financial support extended to regions by the Russian Federation government during the global financial crisis in 2008-2010, for the purpose of exploring its potential impact on the regions' financial health in 2011-2012. The paper is structured around an analysis of the three major dimensions of that support: (1) legal and administrative actions undertaken at the federal level to reduce financial pressure on the regions; (2) increased issuance of intergovernmental fiscal grants in 2009; and (3) loans granted to the regions from the federal budget. The author argues that the financial crisis has provided a stress test that is useful in assessing the efficiency and flexibility of the Russian system of fiscal federalism. | publication |
W1951889025 | Visual and hearing impairment among rural elderly of south India: A community-based study | Of India's population, 76.6 million (7.2%) are aged above 60 years. Increasing age is associated with increasing disability and functional impairments such as low vision, loss of mobility and hearing impairment. Hence, the purpose of this paper is to study the prevalence of hearing and visual impairment among a rural elderly population in South India and its association with selected variables.This was a cross-sectional study of elderly persons in two villages of Bangalore District, Karnataka, South India. Elderly persons identified were administered a questionnaire for assessment of demographic details, health and function related information. Visual acuity was checked using Snellen's E chart for distant vision. Hearing was assessed using pure tone audiometry.Two hundred and fifty-seven (12.2%) of the population were elderly in these two villages. Seventy-two (32.4%) of the elderly persons were facing problems completely or partially in at least one of the activities and 10 (4.5%) elderly persons had cognitive impairment. Sixty-two (35.4%) of the elderly had low vision and 22 (12.6%) were blind. On assessment with pure tone audiometry, 117 (66.9%) of the elderly persons had some degree of hearing impairment. Forty-three (24.6%) of the elderly had disabling hearing impairment. Forty-seven (26.9%) of the elderly had combined low vision associated with hearing impairment and 18 (10.2%) had combined blindness along with hearing impairment. As age advanced there was a significant increase in visual, hearing and combined impairments.Visual and hearing impairment are important health problems among elderly persons in rural areas of South India. | publication |
W2771013534 | Impact of MGNREGA on a Tightened Labour Market | The study discusses the impact of the implementation of the Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA) on an already tightened rural labour market through a field survey conducted in two villages of Rajasthan. The article argues that the impact of the programme in a constricted rural labour market has been marginal because of a low off-take of work because of already developed alternate livelihood strategies which reduced the incentive to work in this programme. Nevertheless, the scheme has been instrumental in two ways: first, it led to the withdrawal of lower caste women from agricultural work which signifies an escape from the exploitative production relations in the two villages under study; and second, it has resulted in the formation of an exclusive category of MGNREGA workers consisting of female workers from the middle castes who were previously were not participating in paid labour. | publication |
978562 | Tracking the path of the agricultural revolution from england to continental europe: changes in pig husbandry from the late medieval to early modern period as a marker of socio-economic transformation | The phenomenon known as the English Agricultural Revolution (18th century) brought significant technological changes in farming practices, such as breed improvements and adoption of more efficient breeding strategies, which are not only the foundation of modern food production systems, but also fundamentally changed human life and shaped our current relationship with animals. This project will use pigs, one of the most common domestic animals, often associated with cultural choices and social status, as a proxy to investigate A) how changes in pig management, which originated and developed in England, spread to Continental Europe and B) the way in which pig husbandry practices were influenced by, and adapted to, the changing economy and society that characterized the transition between the Late Medieval and Early Modern period (1400-1800 AD). This will be done by comparing data from England, where the Agricultural Revolution began, and Bavaria in southern Germany, chosen due to a strong tradition of pig husbandry during the Medieval period and a lack of studies on this topic, making it the ideal ground for investigation. This project will identify the reasons, timing and geographic variation in the response of pig husbandry practices to socio-political changes including the progressive intensification of production, changes in pig size and shape, the generation of intensive sty-keeping feeding regimes and the introduction of new pig stock. To achieve this, the project will undertake a thorough investigation of pig body size and shape; combine biometrical data with Geometric Morphometric analysis to establish if genetically different stock was introduced; complement the zooarchaeological data with stable isotopes analysis to investigate changes in the way pigs were managed; and strive to understand the chronological and geographic variability in the consequences of the transition from the Medieval period to the early Modern age, precursor of the contemporary world. | project/european |
2721549 | A medical device for the selective dissection of pathological tissues and fibrosis | Surgery is the art of dissecting tissues in order to repair, remove, or replace a diseased or damaged organ. 30% of the global burden of disease can be attributed to surgically treatable conditions. More than 10% of surgical procedures involve critical dissection steps whereby the pathological tissue is carefully separated from the healthy surrounding tissues. These procedures together have an incidence of 150/100.000 people, amounting for 2 million surgeries per year in developed countries. Despite the importance of selective dissection in surgical procedures, the current tools are sub-optimal because they are all still relying either on tearing force or on non-selective cutting that can damage tissues.
Auxin Surgery, a pioneer in novel dissection methods, has found a revolutionary system, CADISS, that combines mechanical force with the topical application of a chemical drug, Mesna that weakens adhesion between tissues thereby facilitating the dissection steps and minimizing the damages to health tissues.
CADISS saves time, therefore patients need to undergo anesthesia for shorter period, thereby reducing the risks of complications. Moreover, hospitals save money on the usage of operating rooms and hospital personnel and can optimize the occupation of hospital space.
The global general surgery devices market size was valued at over €10 billion in 2016 and is expected to grow at a CAGR of 8.5% by 2025. Chemically assisted dissection can be useful in most surgical procedures consisting in separation of two tissues along a cleavage plane and when at least one of these conditions is true: 1) the risk of relapse is present 2) the risk of side-effects through damage of healthy tissue is present or 3) the risk of facing difficulties for the surgeon is present. CADISS will bring our company to international expansion and growth reaching €23.9M in revenues 3 years after market launch. | project/european |
W4295771645 | MEIO AMBIENTE, MUDANÇAS CLIMÁTICAS E SEUS IMPACTOS NA SAÚDE COLETIVA | A preservação do Meio Ambiente e projetos voltados ao tema da sustentabilidade. impulsionam a ideia da construção de modelos viáveis e organizados para o enfrentamento de grandes desastres ambientais e alterações na saúde pública. Os efeitos do crescimento da população humana e a aceleração das atividades socioeconômicas impactam diretamente no ambiente que, ao gerar desordens dos ecossistemas naturais, impacta na saúde e no bem-estar dos indivíduos. Assim, busca-se nesse estudo, através da revisão de literatura, fazer um debate teórico entre diversos autores sobre conceitos de políticas públicas, Meio Ambiente, Sustentabilidade e Saúde Coletiva, com vistas a levantar indagações e reflexões sobre os problemas climáticos e de saúde coletiva que a atual sociedade mundial vem enfrentando, com foco especial, no Brasil. Como forma de pesquisa, foi utilizada a revisão integrativa da literatura, a partir de fontes secundárias publicadas sobre os temas encontrados nas bibliografias. | publication |
W3044124012 | PRA RENCANA PABRIK PEMBUATAN ETILBENZENA DENGAN PROSES OKSIDATIF KOPLING METANA KAPASITAS PRODUKSI 280.000 TON PER TAHUN | Ethylbenzene manufacturing plant located on the Cikarang Industrial Estate, West Java. This factory covers an area of 8 hectares with a capacity 280,000 tons per year. The process of making Ethylbenzene carried out by the oxidation process of methane coupling by reacting Methane in the Gas Phase with Oxygen carried out in Reactor-01 (R-01) at a temperature of 800oC and a pressure of 22 atm spent to produce the raw material for making ethylbenzene, ethylene. Ethylene will react again with liquid phase benzene at the reactor (R-02) at 225oC and a pressure of 15 atm to produce:
C2H4+ C6H6 C8H10
This factory is a company that consists of a Limited Company with an organization and staff system, which lead by a president director with a total of 145 employees. Based on the results of an economic analysis, the Ethylbenzene Plant is declared feasible to be established, approved:
a. Total Capital Investment (TCI): US $
b. Cost of production per year: US $ 361,459,103.87
c. Total annual sales: US $ 399,455,788.98
d. Net profit per year: US $ 27,838,551.55
e. Annual Cash Flow (ACF): US $ 30,380,721.63
f. Payment Time: 2 years
g. Return on investment: 85%
h. Breakeven Point: 36%
I. Service life: 11 years | publication |
2714553 | Contact lens embedded sensor for ocular hypertension and glaucoma monitoring | Glaucoma affects over 70 million people worldwide (>12 million in Europe), and this number is expected to grow steadily to reach 111 million by 2040. Glaucoma is a chronic condition with no permanent cure and is the second leading cause of blindness. It significantly reduces the quality of life and presents a heavy burden on healthcare systems. Its most prominent and stealthy form, namely open-angle glaucoma, is mainly caused by chronic ocular hypertension (high intraocular pressure [IOP]). Conventional methods used to diagnose elevated IOP, monitor the progression of glaucoma and create treatment algorithms rely on a single IOP measurement conducted at the clinic. Due to the diurnal cycle of IOP, conventional methods do not provide sufficient and reliable information to evaluate the condition of the patients accurately. GlakoLens has been developing a non-invasive contact lens embedded sensor system that will aid medical professionals to overcome this issue by continuous 24-hour monitorization of the IOP changes. GlakoLens' proprietary technology (1 granted and 3 pending international patents) based on years of cutting-edge scientific research enables superior features for the patient (better comfort, electrical and mechanical safety, and full field-of-view) at a fraction of the cost of the only direct competitor in the market while providing better measurement accuracy and reliability. Four more indirect competitors have recognised the need in the market and are developing products using different technologies to address this need. According to a report by Marketscope, IOP monitoring market is expected to reach €1.5 billion by 2021. Glakolens plans to enter the market by the end of 2022, with estimated revenues equal to about €294.6 million in 2026. | project/european |
W2983733436 | Homomorphically Securing AI at the Edge | Edge devices are becoming increasingly pervasive in everyday life. These devices have become more computationally capable allowing for more complex AI reasoning at the edge. Subsequently, there is a need for protecting data to comply with privacy laws and confidentiality regulations. In this paper, we demonstrate the applicability of homomorphic encryption for protecting the data of AI-enabled cameras at the edge by implementing our solution on a commercial edge device. Our solution comprises a local homomorphic key-value database on an edge device populated by an AI camera; permitting the service of homomorphic search to be performed directly on the edge device. We characterize our implementation demonstrating linear behavior with respect to the database size that the edge device can support. Good enough performance is known to be difficult to achieve when employing homomorphic encryption. Our results are encouraging as we achieved solutions considered to be homomorphically fast, for example, linear performance of 1.28 seconds per database entry at over 256 bits of security. This amounts to a query being processed on a database of 200 entries in ~ 5 minutes. | publication |
W2182112648 | Clinical analysis of intracranial germinoma's craniospinal irradiation using helical tomotherapy. | To evaluate the short-term clinical outcomes of intracranial germinoma patients treated with craniospinal irradiation (CSI) using helical tomotherapy (HT) system in our center.Twenty-three patients who were treated with CSI in our center from January 2008 to July 2012 were collected, with an average age of 20. All of the patients' CSI used the HT system. The total doses were 27-36 Gy/15-20 F (1.5-2 Gy per fraction), and total local doses were 46-60 Gy/30-50 F (5 fractions per week). All female patients for CSI were treated with left-right parallel-opposed field irradiation to protect their ovarian functions. Median follow-up time was 30.9 months (range, 5-67 months). The SPSS19.0 software was used, and the overall survival (OS) was calculated using the Kaplan-Meier method.Among 17 patients with assessable tumors, 9 cases (52.9%) were CR, 7 cases (41.2%) were PR, and 1 case (5.9%) was SD. Hematological toxicity was the severest side-effect occurred in the procedure of CSI. The level 1-4 acute leukopenia were 8.7%, 30.4%, 34.8% and 21.7% and the level 1-4 acute thrombopenia were 8.7%, 30.4%, 21.7% and 8.7%, respectively.For primary intracranial germinomas, HT can be used to implement CSI for simplifying radiotherapy procedures, improving radiotherapy accuracy, enhancing protection of peripheral organs at risk (ORA) and guaranteeing therapeutic effects. With the acceptable acute and long-term toxicity, CSI using HT in intracranial germinoma patients can be a safe and alternative mode. | publication |
Q4112641 | CRÉDIT D’IMPÔT — NOUVELLE PEARL S.R.L. | LA NOUVELLE SOCIÉTÉ, PEARL S.R.L. A L’INTENTION DE RÉALISER UN PROJET D’INVESTISSEMENT CONSISTANT EN L’ACQUISITION DE NOUVEAUX ÉQUIPEMENTS HAUTEMENT SOPHISTIQUÉS, QUI SONT DE HAUTE TENEUR. | project/regional |
US 0341726 W | THREE-FLUID EVAPORATIVE EXCHANGER | An evaporative heat exchanger (10) is provided for the transfer of heat to a first fluid (30) from a second fluid (28) and a third fluid (22) to vaporize the first fluid (30). The heat exchanger (10) includes a core (40), a first flow path (60) in the core for the first fluid (30), a second flow path (66) in the core (40) for the second fluid (28), and a third flow path (68) in the core (40) for the third fluid (22). The core (40) includes a first section (42), a second section (44), and a third section (46), with the second section (44) connecting the first and third sections (42, 46). The first flow path(60) extends through all of the sections (42, 44, 46), the second flow path (66) extends through the first section (42); and the third flow path (68) extends through the third section (46). | patent |
W3015822054 | Utilization of Used-Up Consumer Product Razor Blade for Developing New Experiment | The razor blade has become a commonly available article or consumer product of everyday use. In the present work the double edge stainless steel blades available of some companies in market have been analyzed for their quantitative chemical composition, especially for their important constituents - iron, chromium and to a less extent nickel. Gravimetric method is used for analysis of iron, whereas volumetric method is used for determination of chromium. The spectrophotometric method is tried for estimating nickel. The determination of iron, chromium and nickel from used-up razor blade are newer alternative for usual samples of stainless steel. The work in this study is such that the student of chemistry may get its benefit in learning of experiment developed involving analysis of a common used-up consumer product, razor blade. The student may later think about the relationship between the properties and composition of the material also. This is an attempt for designing an experiment for Analytical Chemistry which may be necessarily incorporated in the practical curriculum for post graduate students of chemistry. | publication |
W2000297682 | Modelling the impact of land use change and rainfall seasonality on sediment export from an agricultural catchment of the northwestern European loess belt | Soil erosion leads to important environmental problems (e.g. muddy floods, reservoir sedimentation) in cultivated areas of the European loess belt. This study aimed to determine the impact of rainfall seasonality and land use change on soil erosion over the last 40 years in a 94-ha cultivated catchment of Normandy (France). To this end, scenarios representative of the different land use conditions were simulated using the STREAM expert-based erosion model. A 13 years long sequence of rainfall events was run with this model. Results showed that erosion increased dramatically after land consolidation (+168% on average). Interannual variability of erosion is important. After land consolidation, 79% of erosion was observed in summer and autumn, even though these seasons only accounted for 58% of annual rainfall kinetic energy. The bulk of erosion was hence produced by a few intense thunderstorms during this period. Thunderstorms correspond to 5% of rainfall events and to 15% of the total rainfall depth, but they generate 51% of total annual erosion after land consolidation (and up to 57% of erosion before land consolidation). Confrontation of the STREAM model outputs with the erosion rates modelled based on Cs-137 measurements suggested that soil redistribution within the catchment was very high but that sediment exports from the catchment remained limited (sediment delivery ratio between 1% and 10%). Local erosion rates derived from Cs-137 measurements showed an important and organised spatial variability, but erosion rates integrated over larger areas remained in the same order of magnitude as those simulated by the STREAM model or were slightly higher. Water erosion would hence not be the only process generating erosion within this catchment. In this context, our results show that tillage erosion cannot be neglected to calculate the sediment budget over several decades. | publication |
222942 | Predictive security for iot platforms and networks of smart objects | The IoT market is currently undergoing transformation from applications involving semi-passive devices operating within a single platform, to applications involving smart objects with embedded intelligence while spanning multiple platforms. State-of-the-art security mechanisms are not sufficient for protecting end-to-end this wave of IoT applications.
SecureIoT is a joint effort of global leaders in IoT services and IoT cybersecurity to secure the next generation of dynamic, decentralized IoT systems, which will span spanning multiple IoT platforms and networks of smart objects, through implementing a range of predictive IoT security services. SecureIoT will architect predictive security services in-line with leading edge reference architectures (RA) for IoT applications (i.e. RAs of the Industrial Internet Consortium, the OpenFog Consortium and the Platform Industrie 4.0), which will serve as a basis for specifying security building blocks at both the edge and the core of IoT systems. SecureIoT will provide concrete implementations of security data collection, security monitoring and predictive security mechanisms, which will be the basis for offering integrated services for risk assessment, compliance auditing against regulations and directives (e.g. GDPR, NIS, ePrivacy), as well as support to IoT developers based on programming annotations. The services will be open and based on the SECaaS (Security-as-a-Service) paradigm.
The SecureIoT services will be challenged in market driven scenarios and use cases in the areas of smart manufacturing (Industrie 4.0), connected cars and IoT-enabled socially assistive robots. Their deployment will be based on both enterprise-scale globally available IoT platforms and community open source platform of the partners. As part of its exploitation strategy, SecureIoT will integrate a multi-sided market platform in order to offer SECaaS services, but also to enable integration of additional security mechanisms in its ecosystem. | project/european |
W185452566 | STATISTICAL METHODS | Data Analysis | A sequence of data entries is called a time series. Most time series have a random character. A time series where there is no correlation from one member of the series to another is called white noise . Models of time series can be constructed from white noise by having each new entry a sum of a white noise contribution and a linear combination of previous entries. Special insights can be gained by examining the Fourier representation of the time series by developing it into a series of sinusoids of different frequency. A brief review of the technique is presented with attention to errors due to the limited sample or record length of a given time series. | publication |
W1543012206 | Millennial-scale diffusive migration of solutes in thick clay-rich aquitards: evidence from multiple environmental tracers | High-resolution one-dimensional profiles of naturally occurring environmental tracers (3H, δD, δ18O, 14C-DIC, 14C-DOC, 36Cl, 4He, and major ions) and hydraulic data were used to study residence times, transport mechanisms, and sources of pore water and solutes in an aquitard system in Saskatchewan, Canada. The aquitard system consisted of 80 m of plastic clay-rich Battleford till discomformably overlying 77 m of Late Cretaceous plastic marine clay. Individual tracers independently revealed molecular diffusion as the dominant transport mechanism in the unoxidized nonfractured till and clay. Transport modeling indicated that late Pleistocene-age pore water at 35–55 m below ground was emplaced 15–30 thousand years Before Present (ka BP) during till deposition and ice retreat. The late Holocene climatic transition was estimated to have occurred 7–12 ka BP. Differences in the timing of events determined with different tracers were attributed to inaccuracies in transport parameters and boundary condition assumptions. This study showed that solute transport in clay-rich aquitards can be accurately predicted for time scales beyond 20 ka, and proved such aquitards are suitable for long-term isolation of most wastes. | publication |
Q4252774 | LIQUIDITY SUPPORT FOR MICRO-ENTERPRISES AFFECTED BY THE COVID EMERGENCY | SUPPORT FOR THE LIQUIDITY OF MICRO AND SMALL ENTERPRISES IN THE RETAIL, SUPPLY AND PERSONAL SERVICES SECTORS WHOSE ACTIVITY HAS BEEN SUSPENDED AS A RESULT OF THE PRIME MINISTERIAL DECREE OF 11 MARCH 2020 | project/regional |
219912 | Understanding how inositol polyphosphates regulate autophagy and lipid body formation in photosynthetic organisms: crosstalk with tor signaling. | The elucidation of regulatory networks that govern cell growth and carbon storage in photosynthetic cells may potentially benefit the world's dependence on the declining reserves of fossil fuels. The growth/carbon sink relationship impacts metabolism, carbon partitioning and productivity but its regulation is poorly understood. Recently, we found a connection between two major cell growth regulators in the model green alga Chlamydomonas reinhardtii. Our findings revealed a synergistic effect between TOR kinase and Inositol polyphosphate (InsP) regulating lipid metabolism and the recycling process of autophagy. Based on the relevance of these results, we aim to find the mechanisms and the conditions in which this intersection takes place within the green lineage. In this sense, we have designed a straight-forward project including different goals. First, we will set novel analytical tools to evaluate the InsP level fluctuations in the presence of new TOR inhibitors and monitor the impact on autophagy flux and lipid metabolism in the model photosynthetic organisms Chlamydomonas reinhardtii and Arabidopsis thaliana. Second, we want to identify the phosphorylation targets of InsPs using Kinome/P-phosphoproteome in a Chlamydomonas InsP-deficient mutant. This analysis will unravel the phosphorylation network of InsP signaling and will provide new insights about the role of InsP in the control of cell growth. Third, we will evaluate InsP levels, autophagy flux and lipid storage under nutritional stress to determine the InsP modulation response in plants and algae. Understanding this signaling pathway will impact metabolic engineering of food and biofuel crops to improve yields of high-value products including oils and lipids. We believe this project will impact a general audience and will help to teach people how basic research can turn into a greater understanding of a process that is conserved in humans and has a direct economic impact. | project/european |
interreg_1570 | Cultural gastronomic particularities: Creation of an identity of the local gastronomic heritage in the region Greece -Italy | The project aims at highlighting the area’s identity emphasizing the cultural and local products, promoting the traditional Mediterranean Gastronomy as a tourist and cultural element in an effort to strengthen local economies, through the following actions: • Recording of common and different gastronomic habits of regions focused on fish and common traditional products; • Documenting the history in terms of nutritional choices throughout the times and highlighting the particular natural and cultural aspects of the regions; • A common gastronomic dictionary, including certain traditional ways of production as well as basic products (utensils, watermills) • An informative video containing cross-border gastronomic particularities (territorial gastronomic path) • Awareness actions (informative materials, spots, campaigns in schools, a gastronomic travelogue in video form, etc.) • Establishing a common quality label for gastronomy to ensure supply of quality service levels within nutrition and dining • Arranging an international food tasting forum in Patras | project/regional |
W2352717464 | Damage Mechanism and Experimental Evaluation Method of Fractured Reservoir during Drilling Process | Based on the study of rock pore structure,stress sensitivity and percolation rules,the method of artificial fracture was used to simulate rock fracture width of the formation to evaluate the drilling fluid damage degree by the means of measuring the different permeability both before and after the core pollution induced by mud.By taking Kazakhstan Kenkiyak Oilfield for example,reservoir damage mechanism was experimentally evaluated during drilling process.The results show that solid particles block core surface when fracture width is very small,however,they invade into the depth of core and cause serious damage as fracture width is greater than 100μm.The wider the fracture is,the serious the formation damage is.Therefore,for the fractured reservoir,balance drilling or underbalanced drilling should be used to the protect reservoir if the fracture is quite wide. | publication |
US 202217885214 A | AUTOMATIC SEQUENTIAL REVIEW ELICITATION | Some embodiments may provide a method and a system for receiving, from a first user, a first evaluation indication with respect to a first publication, and in response to receiving the first evaluation indication, automatically initiating a secondary evaluation process comprising automatically selecting a set of publications including at least a second publication, presenting a first user interface affordance to elicit a selection indication indicating a publication from among the set of publications, receiving a selection indication indicating the second publication, and in response to receiving the selection indication, presenting a second user interface affordance to elicit a second evaluation indication with respect to the second publication. | patent |
169871 | Consumer-Oriented ict solutions for creative smes providing art in bespoke fashion | The main objective of the iART project is to bring visual art into bespoke clothing so as to make apparel products more valuable compared to other garments in the market and to support artists to exploit their work. To reach this objective a set of innovative ICT solutions has to be developed first.
This new approach will also change the business relationship along the conception and design phase in the clothing sector from B2B to B2C, where the artist and the consumer will connect through enabling platforms like iArt. iArt will be built upon an existing B2C webshop for bespoke shirts Bivolino.com.
In particular, the specific ICT developments of the project are:
1. Upgrade the configuration toolkit from 2.5D to 2.5D/3D by including shadowing and rotating features without the need of plug-ins and ease the extension of the catalog to clothing accessories and nightwear fitting with the shirts.
2. Move to real-time online rendering (fabric draping), so as to speed up and increase the flexibility of the whole process from artist design over fabric creation to customized bespoke shirts and other garments (fabric rendering on 2.5D/3D clothing configurator).
3. Build a B2C platform enabling co-creation and user generated art content. Develop an Advanced Artist Interface (AAI) with artist cockpit. Implement an advanced user interface to allow easy 2.5D/3D viewing in many other platforms through open API.
iART is expected to create extra revenues for Artist’s micro SMEs. The European Fashion and Clothing industry SMEs take up ICT enabling innovative supply-chains to generate more revenues through high-margin made-to-order collections which cannot be imported from mass production countries. Finally ICT providers are stimulated to offer innovative tools generating business and turnover.
As this sustainable business model is supported by easily accessible advanced ICT tools (through open API’s) it will be replicable and so has the potential to create a wide impact. | project/european |
US 73418303 A | Liquid crystal display module and assembling method thereof | The liquid crystal display module comprises a bottom cover having a plurality of lamps installed thereon and at least one or more of guide projection formed thereon; and a reflection sheet for reflecting light generated from the lamps and having a guide hole in order to be inserted in the guide projection. | patent |
FI 2004000100 W | DRYER WIRE | The invention relates to a dryer wire. The wire has been woven from a plurality of machine direction (MD) longitudinal yarns (1) and a plurality of cross ma-chine direction (CMD) transverse yarns (2). Furthermore, at least one surface (A, B) of the wire is provided with a plurality of machine direction (MD) grooves (5). In addition, at least some of the longitudinal yarns (1) are arranged to partly overlap each other, thus making the wire structure denser. | patent |
W1496502233 | Star forming galaxies in the AKARI deep field south: identifications and spectral energy distributions | To investigate the nature and properties of far-infrared (FIR) sources from the AKARI Deep Field South (ADF-S), we performed an extensive search for the counterparts of 1000 ADF-S objects brighter than 0.0301 Jy in the WIDE-S (90 $\mu$m) AKARI band in the public databases (NED and SIMBAD). We analyzed the properties of the resulting sample: statistic of the identified objects, number counts, redshift distribution and morphological types. We also made a crude analysis of the clustering properties of the sources and constructed spectral energy distributions (SEDs) of 47 selected objects with the best photometry. Among 1000 investigated ADF-S sources, 545 were identified at other wavelengths. From them, 518 are known galaxies, and 343 of them were not known previously as infra-red sources. We found redshifts of 48 extragalactic objects and morphological types of 77 galaxies. We conclude that the bright FIR point sources observed in the ADF-S are mostly nearby galaxies.Their properties are very similar to properties of the local population of optically bright galaxies, except an unusually high ratio of peculiar or interacting objects and a smaller percentage of elliptical galaxies. The percentage of lenticular galaxies is the same as in the optically bright population which suggests they may frequently contain a significant amount of cool dust. It is possible that source confusion plays a significant role in more than 34% of measurements. The SEDs display a variety of galaxy types, from very actively star forming to very quiescent. Thanks to the AKARI long wavelength bands it was revealed for the first time that these galaxies form a population of objects with very cool dust. | publication |
W2095208939 | Criticism of the philosophy for development of standards for non-ionizing radiation | The new recommendations of WHO and EC for legislation in Europe and other countries concerning non-ionizing radiation (NIR) health and safety include exposure limits that are very debatable. ICNIRP Guidelines propose exposure limits for electromagnetic fields in the frequency range up to 300 GHz based on short-term exposures and on thermal effects. The new EC proposal for optical and laser safety legislation includes classification of sources of radiation—both lasers and other optical sources, but not requirements for the methodology of classification. On the other hand, many new requirements have been set by the WHO publication “Model Legislation for EMF Protection” concerning the responsibilities in the field of EMF health and safety. Many specialists in the field of developing exposure limits have positions very far away from the proposed of the ICNIRP Guidelines philosophy. The results are different approaches in developing standards and exposure limits, and differences more than 100 times in maximal permissible levels. We, the Bulgarian Program Committee on NIR, try to organize working groups and discuss different philosophy for developing exposure limits for more than 10 years. This paper exposes our position in this area. | publication |
W2335211569 | A Time, Energy, and Area Efficient Domain Wall Memory-Based SPM for Embedded Systems | Applications that run in the embedded systems normally should be finished within a timing constraint in energy-efficient fashion. Due to these two requirements, the embedded systems often employ software-controlled scratch pad memory (SPM) instead of hardware-controlled cache as their on-chip memory. The data accesses in SPMs are controlled purely by the software, which provides better time-predictability and precise time-control. In this paper, we propose a time, energy, and area efficient domain wall memory (DWM)-based SPM for embedded systems. To efficiently manage this type of novel SPM, an integer nonlinear programming formulation and the instructions group schedule algorithm are proposed to generate memory access instruction scheduling and data placement. In addition, the longest move reduce algorithm is also proposed to configure different types of DWM memory cells to achieve minimal area size. Experimental results show that the proposed techniques can generate a configuration of DWM-based SPM with minimal area size while satisfying time constraint. | publication |
W870208524 | Parallel implicit anisotropic block-based adaptive mesh refinement finite-volume scheme for the study of fully resolved oblique shock wave reflections | A new parallel, fully implicit, anisotropic block-based adaptive mesh refinement (AMR) finite-volume scheme is proposed, described and demonstrated for the prediction of laminar, compressible, viscous flows associated with unsteady oblique shock reflection processes. The proposed finite-volume method provides numerical solutions to the Navier–Stokes equations governing the flow of polytropic gases in an accurate and efficient manner on two-dimensional, body-fitted, multi-block meshes consisting of quadrilateral computational cells. The combination of the anisotropic AMR and parallel implicit time-marching techniques adopted is shown to readily facilitate the simulation of challenging and complex shock interaction problems, as represented by the time-accurate predictions of unsteady oblique shock reflection configurations with fully resolved internal shock structures. | publication |
BR 112018014785 A | biela de taxa de compressão variável | é provido um conjunto que inclui uma biela, uma bucha e um pino de bloqueio capaz de prover diferentes taxas de compressão em um motor. a bucha é disposta em um furo da biela. uma superfície externa da bucha inclui um par de entalhes, e uma superfície interna da biela inclui um entalhe correspondente para receber o pino de bloqueio. os entalhes são espaçados um do outro por mais de 380º e por não mais que 190º. o pino de bloqueio é móvel no entalhe, permitindo que a bucha gire de uma posição de baixa compressão para uma posição de alta compressão, ou vice-versa. a bucha tem uma espessura variável, e, portanto, um eixo central de uma abertura da bucha está mais próximo do eixo do corpo da biela quando a bucha estiver na orientação de baixa compressão do que na orientação de alta compressão. | patent |
Q82228 | Production implementation of innovative wind turbines as a result of R & D work HIPAR Sp. z o.o. | The project concerns investments in tangible and intangible assets related to the establishment of a new establishment. The company plans to implement a new product as a result of its implementation: low power vertical wind turbines (MEW – small wind turbines). The scope of the project includes the construction of a production hall and the purchase of the necessary equipment with machinery and equipment for direct production of new products. The production hall is necessary for the installation of all machinery and equipment without which serial production cannot be started. In addition, it must be equipped as a separate plant with a social section to meet current health and safety requirements as well as in part over the production plant in the offices used by the company’s employees to carry out activities such as designing, constructing new product assumptions. The offices will be used by the company’s engineering staff for further product development as well as for marketing and sales and accounting purposes for the ongoing operation of the company. The building will be adapted for possible work by people with disabilities even with a high degree of disability. The most important part of the investment and project is the purchase of the necessary machinery and equipment used in the various stages of production of new products – gyms/wind turbines. In addition to investment expenditure within the project, the company wants to finance consultancy and development services closely related to implemented technological and production solutions, which are the results of current research and development. SA 42799(2015/X), Articles 13, 18, 651/2014 | project/regional |
Q123578 | Introduction of a new sales channel in the form of a B2B platform through the use of modern ICT solutions | This project, consisting of the implementation of information and communication technologies, is a strategic undertaking for the company. It deals with many internal aspects of its activity and also affects its external sphere. The project is connected with a fundamental change in the ways of implementing sales processes, and thanks to their improvement and modernisation, it will allow to increase the volume of sold assortment. It is also a cause of marketing and organizational changes, as well as an impulse to increase employment in the company. The investment will also allow for closer cooperation with significant counterparties and to expand the outlets, including through foreign expansion. It will provide a source of innovation, efficiency and development, so important in the activities of each entity. | project/regional |
W2009851213 | Volatile compounds responsible for aroma of Jutrzenka liquer wine | Jutrzenka is a sweet liquer wine produced in Poland from the grape variety of the same name, developed in Poland to withstand the harsh climate of winery regions. Jutrzenka wine has a characteristic aroma with strong fruity and flowery notes, which make it unique among other liquer wines as demonstrated in sensory profile analysis. The work was aimed at characterization of volatile compounds in this wine, with the emphasis on characterization of compounds responsible for its unique aroma. Gas chromatography-olfactometry (GC-O) was applied to identify the key odorants using aroma extract dilution analysis (AEDA) approach. To facilitate free and bound terpenes and C(13)-norisoprenoids identification solid phase extraction (SPE) was used followed by GC/MS. Among identified key odorants β-damascenone was the compound having the highest FD (4096), followed by isoamyl alcohol, 4-mercapto-4-methyl-2-pentanone (FD=2048), methional, linalool, ethyl decanoate (FD=1024) and ethyl hexanoate, furaneol (FD=512). Other significant compounds were ethyl 2-methyl propanoate, ethyl 2-methylbutanoate and phenyl ethyl alcohol. Determination of odor activity values (OAV) showed the highest values for β-damascenone (566), 4-mercapto-4-methyl-2-pentanone (288) ethyl hexanoate (32) and linalool (7). Jutrzenka exhibited also a rich profile of free, and to lesser extent bound terpenes. | publication |
174357 | A new business model for the natural cosmetic market | LaboPhyto is an Italian SME dealing with the manufacturing of naturals products for cosmetics brands – big and small ones. The CosMyFY project aims at developing a new business model oriented to the implementation of own brands and own direct market. Current business model is limited, in terms of growing capability, by traditional clients and their business models. In the natural cosmetics market new player are emerging, offering own brands and working with social network (actually blogs). They are individuals, mainly women, who become « blog lead » and boost number of followers exceeding millions. The great advantage in bloggers’ approach is the direct and complete engagement of the followers both in the product choice (colour, type, functionality) and in its diffusion by the contact chain. Bloggers, however, lack production capability. LPT has his own know how and production capability that will allow to overcome this current market weakness and to aggregate many blogger to implement a new business. This new model will shorten the value chain, improve GM, reduce environmental impact, create new employment and new widespread business opportunities. In the project a local customized production capability is envisaged by adopting local 3D printers, both by the blogger and by associated shops. This step will represent a real disrupting innovation in the market. At the end we will have: A business plan development; The platform COSMYFY integrating technologies (3D printers included), products and bloggers database, Assessed the world market and established a bloggers-own label producers network, Defined a plan for marketing and business development. Pilot application of the new business model built, tested and validated. For the realization of the objective we foresee: A feasibility study that will define aspects for the implementation of the project in Phase2. Dur : 6 mth; In Phase2, the aspects of technological development, industry, market and trade. Dur: 18 mth | project/european |
W2155661744 | From public to private and back again: sustaining a high service-delivery level during transition of management authority: a Cambodia case study | Contracting non-governmental organizations (NGOs) has been shown to increase health service delivery output considerably over relatively short time frames in low-income countries, especially when applying performance-related pay as a stimulus. A key concern is how to manage the transition back to government-operated systems while maintaining health service delivery output levels. In this paper we describe and analyse the transition from NGO-managed to government-managed health services over a 3-year period in a health district in Cambodia with a focus on the level of health service delivery. Data are derived from four sources, including cross-sectional surveys and health management and financial information systems. The transition was achieved by focusing on all the building blocks of the health care system and ensuring an acceptable financial remuneration for the staff members of contracted health facilities. The latter was attained through performance subsidies derived from financial commitment by the central government, and revenue from user fees. Performance management had a crucial role in the gradual handover of responsibilities. Not all responsibilities were handed back to government over the case study period-notably the development of performance indicators and targets and the performance monitoring. | publication |
W2015312787 | Bridging the Research-to-Practice Gap in Autism Intervention: An Application of Diffusion of Innovation Theory | There is growing evidence that efficacious interventions for autism are rarely adopted or successfully implemented in public mental health and education systems. We propose applying diffusion of innovation theory to further our understanding of why this is the case. We pose a practical set of questions that administrators face as they decide about the use of interventions. Using literature from autism intervention and dissemination science, we describe reasons why efficacious interventions for autism are rarely adopted, implemented, and maintained in community settings, all revolving around the perceived fit between the intervention and the needs and capacities of the setting. Finally, we suggest strategies for intervention development that may increase the probability that these interventions will be used in real-world settings. | publication |
W2118078149 | Population balance model based multi-objective optimization and robustness analysis of a continuous plug flow antisolvent crystallizer | Crystallization is a major separation process in the pharmaceutical industry. Most crystallizations are performed batchwise, but there is great incentive for switching to continuous operation. We have investigated the modeling, simulation, optimization, and robustness of a multi-segmented, multi-addition plug-flow crystallizer (MSMA-PFC). The design accepts multiple antisolvent flows along its length, permitting localized control of supersaturation. A mass balance equation was used to track the depletion of dissolved solute (flufenamic acid), and a population balance equation for tracking the crystal size distribution. Multiobjective optimization was done using the antisolvent flowrates into each segment as decision variables. The genetic algorithm was used to calculate the Pareto frontiers for the two competing objectives of maximizing average crystal size (L
43
), and minimizing coefficient of variation (CV). The sensitivity of the Pareto frontier to variation in the growth and nucleation kinetic parameters was investigated. The robustness of a single solution was examined as well with respect to error in the kinetic parameters, as well as to errors in antisolvent flowrate. | publication |
W1942370543 | Integrated management of root-knot nematode Meloidogyne javanica (Treub) Chitwood in fennel ( Foeniculum vulgare Mill.) | Evaluation of organic cakes and nematicides for the management of root-knot nematode (Meloidogyne javanica) on fennel (Foeniculum vulgare) at Kapadvanj (Gujarat) indicated that all the treatments including organic amendments and nematicide either alone or in combination significantly reduced root-knot disease and increased the grain yield over control. Maximum grain yield (2762 kg ha-1) was obtained with the treatment neem cake 1000 kg ha-1 + phorate 1 kg ha-1, which was on par with Neemguard 20 kg ha-1 + phorate 1 kg ha-1 (2566 kg ha-1). Minimum root-knot index (1.64) was recorded in the combined treatment of neem cake 1000 kg ha-1 + phorate 1 kg ha-1, which was on par with castor cake 1000 kg ha-1 + phorate 1 kg ha-1. Maximum net returns (Rs. 22,775 ha-1) was obtained in the treatment neem cake 1000 kg ha-1 + phorate 1 kg ha-1. | publication |
GB 202217702 A | Well insert | A method of controlling the orientation of a well 8 comprises installing a well foundation 4 having a channel 10 therethrough; measuring the angle of the foundation relative to vertical; providing a well insert 2 having a channel 6 therethrough for the well; inserting the well insert into the channel in the installed well foundation; and wherein the well insert corrects for a misalignment of the channel in the well foundation from vertical after the foundation has been installed. The method may comprise providing a plurality of well inserts, wherein each of the well inserts has a different angle between channel of the insert and the outer surface of the insert; and wherein the method comprises selecting an appropriate well insert from the plurality of well inserts and inserting the selected well insert into the channel in the installed well foundation. An appropriate well insert is made once the desired angle of the channel of the insert relative to the outer surface of the insert is determined. The angle of the channel of the well insert relative to the channel of the well foundation may be adjusted based on the measured angle of the foundation. | patent |
EP 93303248 A | Trailing sheet assembly. | Disclosed is an air turn (5) for supporting and optionally drying a web (W), the air turn (5) comprising a plurality of air bars (12a,...,12g) having a trailing sheet assembly like an elongated wing type foil (112) with multiple relief holes and with an adjustable web-to-foil gap and angle. The apparatus of the invention allows for the ability to control the air vortex off the lower air turn in an air turn array and to control the pressure between the web (W) and foil (112), thereby eliminating web flutter. <IMAGE> | patent |
W1882016690 | Influence of niobium on laser de-vitrification of Fe–Si–B based amorphous magnetic alloys | Laser annealing of Fe 77.5 Si 13.5 B 9 and Fe 76.5 Si 13.5 B 9 Cu 1 amorphous melt-spun ribbons was carried out. In both alloys, it was found that devitrification occurred, leading to the nucleation of a high density of refined α-Fe(Si) nanocrystals within the amorphous matrix. Interestingly, when laser processed under identical conditions, Fe 74.5 Si 13.5 B 9 Nb 3 , and Fe 73.5 Si 13.5 B 9 Nb 3 Cu 1 (FINEMET) amorphous melt-spun ribbons did not exhibit devitrification or copper clustering. Differences in the magnetic properties were observed, with the Fe 77.5 Si 13.5 B 9 and Fe 76.5 Si 13.5 B 9 Cu 1 alloys exhibiting higher saturation magnetization (M S ) and higher coercivity (H C ) values while Fe 74.5 Si 13.5 B 9 Nb 3 , and Fe 73.5 Si 13.5 B 9 Nb 3 Cu 1 alloys exhibited lower values of both these properties. These results clearly reveal the enhanced stability of the amorphous phase due to the addition of Nb in Fe–Si–B based melt-spun samples. • Laser annealing of amorphous soft magnetic Fe–Si–B–Cu–Nb (Finemet type) alloys • Coupled influence of rapid heating and cooling and solute elements on de-vitrification • Solute partitioning between nanocrystals and amorphous matrix during laser de-vitrification • Magnetic properties of laser annealed soft magnetic alloys | publication |
W2009872283 | Sex differences in the structural connectome of the human brain | Significance Sex differences are of high scientific and societal interest because of their prominence in behavior of humans and nonhuman species. This work is highly significant because it studies a very large population of 949 youths (8–22 y, 428 males and 521 females) using the diffusion-based structural connectome of the brain, identifying novel sex differences. The results establish that male brains are optimized for intrahemispheric and female brains for interhemispheric communication. The developmental trajectories of males and females separate at a young age, demonstrating wide differences during adolescence and adulthood. The observations suggest that male brains are structured to facilitate connectivity between perception and coordinated action, whereas female brains are designed to facilitate communication between analytical and intuitive processing modes. | publication |
CA 2429517 A | LOW PROFILE MECHANISM FOR STOWING AND DEPLOYING A CARRIAGE WITH RESPECT TO A TRUCK BOX | A carriage with a front end and a rear end can be stowed in a truck box or truck platform, and deployed to a position on the ground behind the truck by providing a lift apparatus having a transfer arm with one end pivoted with respect to the truck and the other end pivoted to the front end of the carriage. Guides are mounted on the lift apparatus to guide the carriage during movement. The carriage has wheels adjacent the rear end, and a powered mechanism, typically hydraulic, is adapted to move the transfer arm between its two extreme positions. As the transfer arm begins to move away from the position in which the carriage is stowed in the truck, the front end of the carriage lifts upwardly while the carriage moves rearwardly, supported and guided by roller guides, until the wheels at the rear end of the carriage contact the surface on which the truck is standing. This causes the carriage to disengage from the roller guides and eventually the carriage com es to a stop resting on the surface. The current invention is designed for use in boxes of limited length. To establish as small a footprint as possible, the lift apparatus is configured with a folding transfer arm and a retractable guide means.</SDOAB > | patent |
W1513068949 | Nervous system development in lecithotrophic larval and juvenile stages of the annelid Capitella teleta | Reconstructing the evolutionary history of nervous systems requires an understanding of their architecture and development across diverse taxa. The spiralians encompass diverse body plans and organ systems, and within the spiralians, annelids exhibit a variety of morphologies, life histories, feeding modes and associated nervous systems, making them an ideal group for studying evolution of nervous systems.We describe nervous system development in the annelid Capitella teleta (Blake JA, Grassle JP, Eckelbarger KJ. Capitella teleta, a new species designation for the opportunistic and experimental Capitella sp. I, with a review of the literature for confirmed records. Zoosymposia. 2009;2:25-53) using whole-mount in situ hybridization for a synaptotagmin 1 homolog, nuclear stains, and cross-reactive antibodies against acetylated α-tubulin, 5-HT and FMRFamide. Capitella teleta is member of the Sedentaria (Struck TH, Paul C, Hill N, Hartmann S, Hosel C, Kube M, et al. Phylogenomic analyses unravel annelid evolution. Nature. 2011;471:95-8) and has an indirectly-developing, lecithotrophic larva. The nervous system of C. teleta shares many features with other annelids, including a brain and a ladder-like ventral nerve cord with five connectives, reiterated commissures, and pairs of peripheral nerves. Development of the nervous system begins with the first neurons differentiating in the brain, and follows a temporal order from central to peripheral and from anterior to posterior. Similar to other annelids, neurons with serotonin-like-immunoreactivity (5HT-LIR) and FMRFamide-like-immunoreactivity (FMRF-LIR) are found throughout the brain and ventral nerve cord. A small number of larval-specific neurons and neurites are present, but are visible only after the central nervous system begins to form. These larval neurons are not visible after metamorphosis while the rest of the nervous system is largely unchanged in juveniles.Most of the nervous system that forms during larvogenesis in C. teleta persists into the juvenile stage. The first neurons differentiate in the brain, which contrasts with the early formation of peripheral, larval-specific neurons found in some spiralian taxa with planktotrophic larvae. Our study provides a clear indication that certain shared features among annelids - e.g., five connectives in the ventral nerve cord - are only visible during larval stages in particular species, emphasizing the need to include developmental data in ancestral character state reconstructions. The data provided in this paper will serve as an important comparative reference for understanding evolution of nervous systems, and as a framework for future molecular studies of development. | publication |
W2918750538 | Next generation sequencing for clinical diagnostics: Five year experience of an academic laboratory | Clinical laboratories have adopted next generation sequencing (NGS) as a gold standard for the diagnosis of hereditary disorders because of its analytic accuracy, high throughput, and potential for cost-effectiveness. We describe the implementation of a single broad-based NGS sequencing assay to meet the genetic testing needs at the University of Minnesota. A single hybrid capture library preparation was used for each test ordered, data was informatically blinded to clinically-ordered genes, and identified variants were reviewed and classified by genetic counselors and molecular pathologists. We performed 2509 sequencing tests from August 2012 till December 2017. The diagnostic yield has remained steady at 25%, but the number of variants of uncertain significance (VUS) included in a patient report decreased over time with 50% of the patient reports including at least one VUS in 2012 and only 22% of the patient reports reporting a VUS in 2017 (p = .002). Among the various clinical specialties, the diagnostic yield was highest in dermatology (60% diagnostic yield) and ophthalmology (42% diagnostic yield) while the diagnostic yield was lowest in gastrointestinal diseases and pulmonary diseases (10% detection yield in both specialties). Deletion/duplication analysis was also implemented in a subset of panels ordered, with 9% of samples having a diagnostic finding using the deletion/duplication analysis. We have demonstrated the feasibility of this broad-based NGS platform to meet the needs of our academic institution by aggregating a sufficient sample volume from many individually rare tests and providing a flexible ordering for custom, patient-specific panels. | publication |
W867257094 | Developments since 2005 in understanding potential environmental impacts of CO2 leakage from geological storage | This paper reviews research into the potential environmental impacts of leakage from geological storage of CO2 since the publication of the IPCC Special Report on Carbon Dioxide Capture and Storage in 2005. Possible impacts are considered on onshore (including drinking water aquifers) and offshore ecosystems. The review does not consider direct impacts on man or other land animals from elevated atmospheric CO2 levels. Improvements in our understanding of the potential impacts have come directly from CO2 storage research but have also benefitted from studies of ocean acidification and other impacts on aquifers and onshore near surface ecosystems. Research has included observations at natural CO2 sites, laboratory and field experiments and modelling. Studies to date suggest that the impacts from many lower level fault- or well-related leakage scenarios are likely to be limited spatially and temporarily and recovery may be rapid. The effects are often ameliorated by mixing and dispersion of the leakage and by buffering and other reactions; potentially harmful elements have rarely breached drinking water guidelines. Larger releases, with potentially higher impact, would be possible from open wells or major pipeline leaks but these are of lower probability and should be easier and quicker to detect and remediate. | publication |
986699 | Modal nonlinear resonance for efficient and versatile legged locomotion | The aim of M-Runners is to thoroughly advance the understanding of fundamental dynamic principles of legged locomotion to the point that those principles can be used to design robots which display similar motion characteristics, versatility, and efficiency as their biological paragons. The central hypothesis of the project is that biological locomotion is fundamentally determined by the mechanical resonance properties of the body and that a breakthrough in robot locomotion is essentially linked to understanding and exploiting these phenomena. If body design is such that walking and running correspond to intrinsic periodic motions of the body, then the control is simple and efficiency and robustness are natural consequences. However, large-amplitude nonlinear oscillations of such complex systems are today still not well understood. Mathematical methods to describe, analyze, design and control elastic resonant robots are lacking to a large extent. The project is thus dedicated to develop a new theory of nonlinear oscillations, applicable to elastic multibody systems, be they biologic or robotic.
M-Runners will perform interdisciplinary research at the border between robotics, nonlinear dynamical systems and vibration theory, biomechanics, and machine learning. We will take inspiration from biology regarding the basic motion sequences and the muscle arrangements (couplings, redundancies, compliance distributions). Conversely, we expect our theory to generate new hypotheses for a deeper understanding of locomotion biomechanics and its control by the nervous system.
We will design and demonstrate robots which can move at similar speed and mechanical energetic efficiency as animals and humans and which have comparable uneven terrain versatility and robustness. The primary application scenario is space exploration on Mars in canyons, caves or steep ridge slopes. Applications of the technology reach, however, from health-care over personal-assistance to disaster management. | project/european |
W1943907665 | Effect of spray application parameters on viability of rhizobacteria used as bio-pesticides in organic fruit production | The biocides, either synthetic pesticides or biopesticides, are applied with agricultural sprayers in form of an atomised spray liquid, being usually a solution or suspension of the control agent, i.e.: synthetic active ingredient, microorganism or extract of naturally occurring material. Prior to the atomisation the spray liquid is subject to a turbulent flow and series of processes taking place in different sprayer components. In the pump the liquid is in turns compressed and decompressed at the frequency of 10-50 Hz (diaphragm or piston pumps) or subject to mechanical rotation at high speeds of 1500-3500 RPM (centrifugal pumps). In the filters the compressed liquid passes the mesh, in the control devices such as valves and gauges it flows at high speed passing sharp edges, and finally in the nozzles it is atomised by mechanical breaking or tearing apart. During all these processes the sprayer components and their working parameters harshly interact with the particles suspended in the liquid and usually they cause an increase of the liquid temperature. The leaving micro-organisms in biopesticides are subject to unfavourable conditions being far from those of their natural habitat. Thus, the question about viability of microbes under these conditions is very important for the efficacy of biopesticides. The objective of this study was to evaluate the survival of two strains of PGPR (Plant Growth Promoting Rhizobacteria), showing potential of application in organic fruit growing, by performing the stress tests simulating spray application process with both the hydraulic and the pneumatic atomisation system. | publication |
882925 | European climate prediction system | The European Climate Prediction system project (EUCP) has four objectives, all directly relevant to the work programme, and fully meet the challenge, scope and impact of the work programme.
1. Develop an innovative ensemble climate prediction system based on high-resolution climate models for Europe for the near-term (~1-40years), including improved methods used to characterise uncertainty in climate predictions, regional downscaling, and evaluation against observations.
2. Use the climate prediction system to produce consistent, authoritative and actionable climate information. This information will be co-designed with users to constitute a robust foundation for Europe-wide climate service activities to support climate-related risk assessments and climate change adaptation programmes.
3. Demonstrate the value of this climate prediction system through high impact extreme weather events in the near past and near future drawing on convection permitting regional climate models translated into risk information for, and with, targeted end users.
4. Develop, and publish, methodologies, good practice and guidance for producing and using authoritative climate predictions for 1-40year timescale.
The system (objective1) will combine initialised climate predictions on the multi-annual timescale with longer-term climate projections and high resolution regional downscaling, using observations for evaluation. Methodologies will be developed to characterise uncertainty and to seamlessly blend the predictions and projections. Users will be engaged through active user groups. The system will be utilised (objective2) with users to co-produce information suitable for European climate service activities. A set of demonstrators will show the value of this information in real-world applications with user involvement (objective3). Key outputs will include disseminating and publishing the project’s methodologies, and user-relevant data and knowledge (objective4). | project/european |
EP 2020072817 W | GPR DEVICE WITH ADAPTIVE ANTENNA MOUNT | A ground-penetrating radar (GPR) device comprises a frame (1), a radar antenna (21), and an antenna assembly (2), wherein the antenna is part of the antenna assembly (2). Further the GPR device comprises a mount (3) for adaptively mounting the antenna assembly (2) to the frame (1) and a ground support (12) for supporting the frame (1) on the ground. In an operational state, the mount (3) prevents a horizontal displacement of the antenna assembly (2) relative to the frame (1) in two horizontal directions. In the operational state, the mount (3) further allows a vertical displacement of the antenna assembly (2) relative to the frame (1) and a tilting of the antenna assembly (2) relative to the frame (1). | patent |
3739472 | Time encoded voice interfaces | The research of this EID focuses on ultra-low power sensors incorporating artificial intelligence. The current solution for such systems requires an analog-to-digital converter (ADC) prior to the signal processing block, usually implemented with a neural network (NN). The innovation consists of removing the ADC prior to the NN by directly coupling the sensor to it and encoding the sensor signals with a voltage-controlled-oscillator (VCO). VCO-based ADCs have been used to implement integrated sensors. Achieving this goal requires to develop a new multiply-accumulate cell (MAC) for the first layer of the NN that operates with signals from the VCO, and a suitable VCO interfaces with existing sensors. In most applications, the raw data form the sensor is required as well. Here, signals coming from the VCO can also be converted to a sampled sequence by enabling a digital decoder, which is not needed when detecting a pattern in the NN. As a benefit, power consumption can meet the requirements of battery-operated products. Power improvement comes from both the ADC removal and the power efficiency of the NN implementation. Approaches to implement a sensor interface using a VCO and to implement a phase/frequency-encoded MAC unit (P-MAC) for a NN have been attempted separately but, there is no combination of both ideas. The research in this EID tries to bridge this gap. This architecture can be useful for both research and industrial applications, such as neural probe chips, wearable electronics or battery powered IoT devices. This EID proposal requires intersectoral involvement of both academia and the industry, to develop a doctoral program and train researchers that will be in high demand by having the specific skills developed in this research. We have selected waterproof smart microphones as an application to benefit from this research, which may directly lead to a product development of interest to microelectronic industries in the EU producing MEMS microphones. | project/european |
W43286741 | High-Throughput Organic Synthesis in Microreactors | Abstract With an average lead time of 10–12 years for a compound to progress from initial identification through clinical trials and finally into a medicine, the pharmaceutical industry are interested in the development of techniques which have the potential to reduce the time taken to generate prospective lead compounds and translate the protocols into production. As such, one of the areas of synthetic chemistry that has benefited greatly from microreaction technology (MRT), over the past 15 years, has been that of pharmaceutical research and development (Glasnov and Kappe, 2007; Mason et al., 2007); with interest in the technology stemming from the perceived ease with which reaction conditions can be optimized and subsequently employed across a range of substrates in order to generate compound libraries (Kirschning et al., 2006; Wiles and Watts, 2007a; Wiles and Watts 2008a). The rapid translation of reaction methodology from the microreactors employed within an R&D facility to production, achieved by a process referred to as scale-out, numbering-up, or upscaling, also has the potential to reduce the time taken to take a compound to market (Yoshida, 2008). Based on this notion, research into the use of microreactors as tools for high-throughput organic synthesis has grown in popularity, with the last 5 years seeing an emerging trend in the types of compounds prepared changing from proof of concept reactions, to the synthesis of molecules of direct relevance to the pharmaceutical industry. With this in mind, the chapter begins with an overview of the seminal examples that helped to foster interest in microreactors as high-throughput tools, illustrating liquid phase (Sections 2.1–2.3), catalytic (Section 2.4) and photochemical (Section 2.6) reactions, and concludes with a selection of current examples into the synthesis of industrially relevant molecules using MRT (Section 3). | publication |
SE 2022050825 W | WIRELESS TERMINAL, NETWORK NODE AND METHODS IN A WIRELESS COMMUNICATIONS NETWORK | A method performed by a wireless terminal is provided. The method is for handling Quality of Experience (QoE) in a wireless communications network. The QoE relates to a service provided at an application running on the wireless terminal. The wireless terminal logs (402, 403, 404) indications indicating a requested system information and its impact on the QoE for the provided service at the application. The wireless terminal sends (407) the logged indications to a network node. The logged indications enable a network node to adapt any system information configuration. | patent |
W1531126550 | An ultra-miniature quarter-mode SIW bandpass filter operating at first negative order resonance | This paper presents an ultra-miniature bandpass filter based on quarter-mode substrate integrated waveguide (QMSIW) cavity with negative-order resonance. Ramp-shaped slots are used as interdigital capacitors (IDCs) to force the structure to operate in the negative order resonance mode. A patch with triangular slots in an additional middle metal layer along with disconnected vias is also used to increase the equivalent series capacitance of the IDC and shifting down the ??1st resonance for more miniaturization. The 2-pole filter has a center frequency of ∼690 MHz with an area of ∼0.05⋌ 0 × 0.09⋌ 0 . The measured insertion loss is 2.1 dB and return loss is better than 30 dB. By employing the −1st order resonance, measured out-of-band rejection of >30 dB up to ∼2.1 GHz is achieved. To the best of authors' knowledge, miniaturization factor of ∼91% compared to a conventional 2-pole SIW filter shows this is the most compact SIW 2-pole filter reported in the literature. | publication |
633225 | Mixed reality for upper-limb stroke rehabilitation | The recovery of the functional use of the upper limb is a main goal of rehabilitation in stroke survivors. Despite the development of many rehabilitation programs, upper limb paresis following a stroke still results in disability and a great societal cost. Attention deficits are also common in these patients. Here we propose two mixed-reality (MR) interventions to improve functional outcomes of the rehabilitation interventions as compared with classic rehabilitation programs. MR interfaces allow patients to use real world objects while interacting with virtual images, which enhances the use of real world objects. Virtual Reality allows recreating an ecological setting, which is key to the transfer of the rehabilitation outcomes. In the first intervention, patients will be able to train with real and also the same virtual objects and that in an enriched environment. To better understand how MR contributes to the mechanisms of neuroplasticity, in this first experiment, we also seek to compare cinematic measures of object manipulation (virtual vs. real). In the second MR intervention, an avatar will mimic the patient’s gestures and movements with real objects. This will give the patient an allocentric perspective of their movement. Moreover, these interventions will allow us to test the hypothesis that a MR motor training environment might have a beneficial effect on attention.
Participants will be recruited from the pool of patients from the stroke outpatient program of NISA Hospital and clinical staff will contribute to data collection. The outcomes of those interventions will be compared with the outcomes of the conventional rehabilitation program (i.e. occupational therapy and physiotherapy without virtual or MR). We will not only assess motor function, but also attention and motivation. We expect to find better outcomes by following the MR interventions. | project/european |
623891 | Addressing challenges toward the deployment of higher automation | Hi-Drive addresses a number of key challenges which are currently hindering the progress of developments in vehicle automation. The key aim of the project is to focus on testing and demonstrating automated driving, by improving intelligent vehicle technologies, to cover a large set of traffic environments, not currently achievable.
Hi-Drive enables testing of a variety of functionalities, from motorway chauffeur to urban chauffeur, explored in diverse scenarios with heterogeneous driving cultures across Europe. In particular, the Hi-Drive trials will consider European TEN-T corridors and urban nodes in large and medium cities, with a specific attention to demanding, error-prone, conditions.
The project’s ambition is to considerably extend the operational design domain (ODD) from the present situation, which frequently demands interventions from the human driver. Therefore, the project concept builds on reaching a widespread and continuous ODD, where automation can operate for longer periods and interoperability is assured across borders and brands. The project also investigates what factors influence user behavior and acceptance, as well as understanding the needs of other road users interacting with these vehicles. The removal of fragmentation in the ODD is expected to give rise to a gradual transition from a conditional operation towards higher levels of automated driving.
With these aims, Hi-Drive associates a consortium of 41 European partners with a wide range of interests and capabilities covering the main impact areas which affect users, and the transport system, and enhance societal benefits. The project intends to contribute towards market deployment of automated systems by 2030. All this cannot be achieved by testing only. Accordingly, the work includes outreach activities on business innovation and standardization, plus extended networking with the interested stakeholders, coordinating parallel activities in Europe and overseas. | project/european |
W2022740672 | The Effect of Chronic Disease Family History on Healthcare Provider Practice and Patient Behavior among Oregonians | Family history is an independent risk factor for many chronic conditions. Therefore, efforts to prevent these diseases among asymptomatic people at high familial risk are justified to reduce the health burden of these chronic conditions. We analyzed 2006–2009 Oregon Behavioral Risk Factor Surveillance System data to examine associations between family history of diabetes, cardiovascular disease (CVD), colorectal cancer (CRC), breast cancer (BC), and: (1) patient-reported clinician recommendations, (2) adoption of preventive and screening behaviors, and (3) chronic disease risk factors among respondents without a personal history of the condition. A positive family history was associated with a higher likelihood of reported discussion by clinicians of CRC and BC screening and a greater likelihood of respondents having cholesterol and CRC screening. The combination of family history and clinician recommendations significantly increased the odds of CRC and BC screening compared to family history alone. A positive family history was also associated with respondents reporting lifestyle changes to prevent diabetes, CVD, and CRC, but not BC. Awareness of family history prompts clinicians to recommend screening and may motivate patients to be screened. Understanding positive family history may also motivate patients to adopt healthy lifestyles. | publication |
895723 | An etymological dictionary of the japonic languages | It is a paradoxical situation that with Japan being the third modern economy and Japanese, the main Japonic language, being the 10th in the world in terms of native speakers and the most widely studied Asian language, the Japonic language family still lacks an etymological dictionary.
The present research project will rectify this situation. The benefits of an etymological dictionary of Japonic are obvious: not only it will be of a great use to the specialists working on pre-modern Japan and Ryukyuan islands in various disciplines; it will have its impact on modern studies, especially on linguistic identities in East Asia. And offer a new reading of regional linguistic identities
The Etymological Dictionary of the Japonic languages has never been compiled, and the time for the realization of such a project is ripe, as it would have been impossible to carry on 30 or 40 years ago, since many important resources available now did not yet exist then such as numerous dictionaries and descriptions of dialects and historical stages of the language development. The same is true regarding the editions of many textual sources and compilation of their indexes. One very important difference with the previous era is also the fact that nowadays many sources are available electronically, which greatly facilitates the search and management of information. This project is highly innovative because it provides a presentation in context based on the extensive use of the IT technology, as compared to the previous research on Japonic etymology which was essentially word-list-oriented. In contrast with the current practice, where only word entries with their translations were provided (and often without any reference to the source), thanks to internet link to database, and cross-referenced entries, the electronic etymological dictionary will present the words in their textual historical and cultural context. | project/european |
172864 | Understanding and exploiting the insect p450 resistome | Insect resistance to synthetic insecticides and the anti-herbivore defence chemicals produced by many plants is an ongoing challenge to sustainable pest management while also an exceptional model system to study adaptive evolution. The cytochrome P450s are a superfamily of enzymes that are ubiquitous in nature, and one of the most important enzyme families used by insects to defend themselves against natural and synthetic xenobiotics. Insects have been shown to evolve resistance through quantitative changes in P450 expression or via qualitative changes in P450s that alter metabolic activity. Despite their importance in conferring resistance the variety of regulatory changes that modulate P450 expression in resistant insects and their relative frequency/impact is not fully understood. Furthermore, although qualitative changes in insect P450s associated with resistance are relatively rare they represent a unique opportunity to characterise insecticide/toxin binding and identify the critical structure/function determinants of the P450/insect toxin interaction.
In this project I will exploit cutting-edge advances in genomics, epigenetics and transgenics to study the insect P450 resistome in three main workpackages:
WP-1: Will identify the molecular drivers of quantitative changes to insect P450s.
WP-2: Will explore the role of qualitative changes in insect P450s in mediating resistance and identify structure/function determinants of insecticide metabolism.
WP-3: Will exploit the knowledge gained in WP1/2 and from previous research to deliver a ‘P450 toolkit’ consisting of in vitro and in vivo screening tools, with which to identify resistance breaking chemistry, and high-throughput diagnostics for use in resistance management.
In summary this project will provide novel insights into this important enzyme family and provide tools that can be used to develop new products and strategies that slow, prevent, or overcome resistance and so ensure sustainable crop protection | project/european |
W4312276086 | La recezione dell’opera di Rubem Alves in Italia: contributo pedagogico e teologico | Se si tratta di provare a descrivere la recezione del pensiero di Rubem Alves attraverso le pubblicazioni apparse nel mercato editoriale italiano, la prima cosa da fare è provare a rendere conto delle stesse, in una per quanto rapida presentazione. Dopo le opere di carattere teologico tradotte in italiano ancora ad inizio anni ’70 (“Teologia della speranza umana” e “Il figlio del domani” entrambi per Queriniana), un certo successo editoriale lo gode il libro “Parole da mangiare” (edizioni Qiqjaon, 1998). Qualche anno dopo, per i tipi EMI viene pubblicato “La scuola che ho sempre sognato” (2003), mentre l’editore Qiqiaon propone un altro piccolo volume dal titolo “Il canto della vita” nel 2013. Se fin qui si tratta di traduzioni, nel 2014 l’editore Pazzini pubblica un volume che raccoglie e ordina i brevi racconti che Alves mensilmente pubblica, a partire dal 1999, nella rubrica “La pagina di Alves” sulla rivista interculturale “CEM-mondialità”. Così anche il volume dal titolo “Pedagogia del desiderio” dell’anno successivo, pubblicato da EDB, è una raccolta scelta tra i tanti racconti di carattere educativo e pedagogico di Alves apparsi nella rivista. Nel 2018, infine, ancora la comunità di Bose, responsabile delle edizioni Qiqajon, pubblica un nuovo libretto a firma di Alves sui temi della fragilità e della vecchiaia titolandolo “La bellezza del crepuscolo”. | publication |
Q2861522 | We Translate for Europe | We Translate On Time is an online translation company that combines professional translation (certified and uncertified) with technological innovation, to provide high quality translations at affordable prices. It aims to become the leading online translation reference company in the global market. | project/regional |
W1626930094 | Who are at risk for tuberculosis recurrence | Multi-drug resistance (MDR) is much higher among recurrent tuberculosis cases than among new cases in Latvia and globally. Aim: To find out the risk factors for TB reinfection (RI) and reactivation (RA). Design and methods: Retrospective case control study. Non-probability convenience sampling of retreatment cases (RC) according to WHO definitions of 54 available M.tuberculosis (MT) cultures for current and previous TB episodes from years 1999 to 2007. Drug sensitivity test and genotyping in both episodes, data extraction. Cases (RI) - 43 TB RC with genotipically different MT in both episodes, suggesting reinfection with different strain. Controls (RA) 11 TB RC with genotipically identical MT in both episodes, suggesting reactivation. Results: 31 RI cases (72%) in previous TB episode was treated in hospitals till the year 2002 (OR 4.52, p MT strains, predominantly (70%) Beijing and LAM9 genotype. Controls in 45% were MDR, with acquisition of drug resistance and prevalence of Beijing and LAM9 genotype in 73%. Conclusion: Non-MDR TB patients were at risk for reinfection with MDR MT strains during prolonged hospitalization in conditions of poor infection control. To decrease risk of TB transmission in hospitals; strong infection control measures and ambulatory treatment should be enforced. As a risk factor for TB relapse drug resistant MT in the previous episode is suspected. | publication |
W3021792406 | Real-space approach to cosmic microwave background deboosting | The effect of our Galaxy's motion through the Cosmic Microwave Background rest frame, which aberrates and Doppler shifts incoming photons measured by current CMB experiments, has been shown to produce mode-mixing in the multipole space temperature coefficients. However, multipole space determinations are subject to many difficulties, and a real-space analysis can provide a straightforward alternative. In this work we describe a numerical method for removing Lorentz- boost effects from real-space temperature maps. We show that to deboost a map so that one can accurately extract the temperature power spectrum requires calculating the boost kernel at a finer pixelization than one might naively expect. In idealized cases that allow for easy comparison to analytic results, we have confirmed that there is indeed mode mixing among the spherical harmonic coefficients of the temperature. We find that using a boost kernel calculated at Nside=8192 leads to a 1% bias in the binned boosted power spectrum at l~2000, while individual Cls exhibit ~5% fluctuations around the binned average. However, this bias is dominated by pixelization effects and not the aberration and Doppler shift of CMB photons that causes the fluctuations. Performing analysis on maps with galactic cuts does not induce any additional error in the boosted, binned power spectra over the full sky analysis. For multipoles that are free of resolution effects, there is no detectable deviation between the binned boosted and unboosted spectra. This result arises because the power spectrum is a slowly varying function of and does not show that, in general, Lorentz boosts can be neglected for other cosmological quantities such as polarization maps or higher-point functions. | publication |
170484 | Cerebellar distributed plasticity towards active sensing and motor control | The ability to perceive and understand the state of the surrounding environment and the own state is critical for next generation robotic systems. To that aim, the human brain is still far beyond current artificial systems performance due to its capability of processing huge amounts of heterogeneous sensorial data. Interestingly, the cerebellum has been shown to play a crucial role in the generation of dexterous movements as evidenced from cerebellar ataxic patients. Behavioural studies suggest that the cerebellum actively improves sensorial discrimination and proprioception thanks to the prediction of the sensorial consequences of actions. In the last decade, several forms of long-term synaptic plasticity have been observed within the cerebellum, suggesting that distributed plasticity could support the predictive action. However the way in which those mechanisms cooperate in order to improve the function of the whole cerebellar network is not completely understood. In this project, the candidate will develop a novel theory of sensorial information representation and processing based on the cerebellar architecture. The proposed model will make use of long-term synaptic plasticity mechanisms distributed along connections existing in the cerebellar input layer (granular layer) to iteratively create sparse representations of the information, allowing fast and effective learning in successive layers. The predictions extracted from this model will be useful to design new experimental protocols to unveil the cerebellar role in acting and sensing.
By providing multiple relevant contributions across the spectrum of the H2020 objectives in terms of its potential to advance robotic manufacturing, brain processing understanding, and novel computing paradigms, this project will enable the candidate to enhance his position at the forefront of advances in this field. | project/european |
W2149798938 | BODY WEIGHT AS A DETERMINANT OF CLINICAL EVOLUTION IN HAMSTERS (Mesocricetus auratus) INFECTED WITH Leishmania (Viannia) panamensis | SUMMARY The clinical outcome of infection with Leishmania species of the subgenus Viannia in hamster model (Mesocricetus auratus) has shown to be different depending on experimental protocol. Body weight has been a relevant determinant of the clinical outcome of the infection in hamsters with visceral leishmaniasis but its importance as a clinical parameter in hamsters with cutaneous leishmaniasis is not known. In this study, the clinical evolution of infection with L. (V) panamensis was evaluated in juvenile and adult male hamsters during 11 weeks by comparing clinical parameters such as attitude, temperature, respiratory rate, appearance of the stool, and body weight between infected and non-infected groups. Results showed that body weight decreased in adult hamsters after infection by L. (V) panamensis; this observation supports the use of body weight as an additional parameter to define the management or treatment of cutaneous leishmaniasis in infected adult hamsters used as an animal experimental model for leishmaniasis. | publication |
174777 | Development of simple to use point of care tests for zoonotic pathogens and their validation for use in clinical research setting | Our major goal is development of simple to use point of care tests for zoonotic pathogens and viral hemorrhagic fevers (VHF), and their validation for use in clinical research setting.
Zoonosis is any process whereby an infectious disease is transmitted between different species of animals. The term zoonosis is here used specifically to refer to diseases that originate in other species of animal, but that get transmitted to humans. Zoonoses in which humans are infected may originate in either domestic animals or wildlife, such as insects, mammals, reptiles, bats, or birds.
This application contains a draft business plan with feasibility study that verifies the technical and economic viability of the new diagnostics in the proposed clinical validation.
In phase 1 a comprehensive business plan will be produced aiming in phase 2 to develop a comprehensive rapid response diagnostic system for zoonotic pathogens and hemorrhagic fever viruses, with implications for surveillance of all emerging pathogens. Furthermore, in phase 2 the developed tests will be evaluated by end users of the tests – by several research and clinical diagnostic laboratories. | project/european |
W2016841909 | Solving coverage problem in wireless camera-based sensor networks by using a distributed evolutionary algorithm | Wireless camera-based sensor networks have developed as a main group of distributed intelligent systems. These systems involve huge number of low-power camera nodes to display an environment such as museums, military regions, airports, traffic control etc. One of the more important problems in smart networks is camera coverage control. It is necessary to allow automatic tracking of targets and monitoring the environment without human intervention, allowing these systems to scale. Since this problem is NP-hard, even for static targets, so Meta heuristic method such as genetic algorithm, Particle swarm optimization have been proposed to achieve near-optimal solution, which are with high time complexity. To overcome problem the distributed particle swarm optimization is examined in this paper. Simulation results show that the distributed particle swarm optimization results near-optimal solution faster. | publication |
3738376 | Enabling carbon accounting of trees on farms for agroforestry-based climate action | Agriculture is a major driver of deforestation and greenhouse gas (GHG) emissions. Meeting the increasing demand for land and agricultural products, without compromising the Sustainable Development Goals (SDGs) agenda, will require a sustainable transformation of agricultural systems. Among the solutions, agroforestry systems which integrate trees, crops and livestock on farms, without requiring additional agricultural land, provide adaptation and mitigation to climate change and improve livelihoods. Despite its benefits, agroforestry is often not accounted for in measurement, reporting and verification (MRV) systems, which are a requirement for fulfilling countries’ climate goals under the Paris Agreement. If agroforestry is not included, incentives for leveraging on-farm trees for addressing climate change will be limited. Three scientific and technical gaps prevent the access of agroforestry to climate-finance: 1) Lack of accessible approaches for the representation of agroforestry in MRV systems; 2) Shortfall of data and tailored methods for carbon accounting in agroforestry systems; 3) Institutional barriers that withhold agroforestry from access to MRV and climate finance. The aim of this project is to develop and field-test robust, cost-effective approaches to account for carbon in agroforestry systems and enable innovative environments for climate finance. Three working packages (WP) will contribute to fill the existing gaps: WP1) Accessible detection, classification and representation of agroforestry systems; WP2) Development of methods for rapid, non-destructive quantification of carbon in agroforestry; WP3) Enablement of novel environments for agroforestry-based climate finance. The project outcomes will provide not only accessible tools and robust methods to facilitate carbon accounting in agroforestry, but also a link to climate finance. This combination will generate a multidisciplinary approach to catalyze agroforestry-based climate action. | project/european |
AU 1934/098007 W | FOOD MIXER WITH IMPELLER WITH REVERSIBLE ROTATION | A food mixer which includes a container having an impeller adapted to be driven by drive means adjacent the lower surface of the container and which impeller is adapted both to cooperate with various mixing devices and to rotate in either the clockwise or anti-clockwise direction. | patent |
IB 2020057073 W | CONTROL SYSTEM AND METHOD FOR MANAGING SEWING MACHINES | An electronic unit (3) of a control system (1) for managing sewing machines (2) is placed operatively in contact with a sewing machine (2). The electronic unit (3) comprises a detection module (5) configured to detect vibration data related to the vibrations induced by the sewing machine (2). The vibration data detected are associated with a univocal identification code (X1, X2, X3,...), which univocally identifies the electronic unit (3) and the sewing machine (2). A vibration curve (C) is generated which comprises the vibration data detected by the detection module (5) as a function of the time (t). The operating module (8) is configured to identify in the vibration curve (C) an elementary curve (E) characteristic of the sewing machine (2), which is saved in a storage module (9). The operating module (8) is configured to compare the vibration curve (C) with a characteristic elementary curve (E) saved in the storage module (9). | patent |
W628185556 | Crimean Tatars From Mass Deportation to Hardships in Occupied Crimea | The article begins with a description of the deportation of Crimean Tatars. It provides a brief review of the German Occupation of Crimea, examines the negative images of Crimean Tatars published in Soviet newspapers between 1941-1943 and the explicit rationale given by the Soviet authorities for the deportation of Crimean Tatars, and reviews the mitigation of hostilities against Tatars in the years following the war. The article continues with accounts of the attempts to repatriate Crimean Tatars after 1989 and the discriminative policies against the returning people. The conclusion of the article describes current hardships experienced by Tatars in occupied Crimea. The last seventy years have presented Crimean Tatars with profound challenges and enormous hardship. They suffered greatly at the hands of the Soviet government during their deportation of 1944 and their return in the late 1980s, and they are being discriminated against by the Russian Government following the annexation of Crimea in 2014. After the Soviets recaptured Ukraine from the Wehrmacht in 1944, Crimean Tatars were deported to Central Asia based on accusations of willingly supporting the enemy, killing innocent Ukrainian civilians, and conspiring to establish a Crimean Tatar republic under German rule. The presentation of this group as traitors and enemies of the Soviet people was used as a foundation for discriminative policies during their return to Crimea. Now they are facing oppressive measures implemented by the Russian government in Crimea, which are being justified based on accusations of extremism and radicalism. In order to understand the structures and dynamics of the current identity-based conflict in Crimea that has led to the brutal oppression of Crimean Tatars after the Russian annexation of Crimea in 2014, it is necessary to understand the political and social legacies of Stalinist repression, and the impact of that repression on the development of the systems of identity for Crimean Tatars and Russians over the last fifty years. The case study presented in this paper covers a vastly understudied area in the literature of Ukrainian studies, Russian studies, and genocide studies, which has theoretical and practical implications for our understanding of conflict and identity in post-Soviet Russia, and the on-going conflict in Ukraine. The analysis in this article represents a clear case of categorical violence. Johan Galtung developed the concepts of direct, cultural, and structural violence. 1 While direct violence describes open cases of aggression, structural violence is understood as injustice and exploitation built into a social system of inequalities, and cultural violence is based on the prevailing attitudes and beliefs in the society. This article shows that Crimean Tatars were victims of all three forms of violence described by Galtung. They were deported by the Stalinist regime, were harassed upon their return to Crimea in 1990s and brutally beaten and killed during the current occupation regime in Crimea. The political structures of Soviet Union and current Putin's Russia supported these aggressive policies, while a culture of paternalism and submission to power justified violent actions. This article states that the prevailing form of violence against Crimean Tatars was categorical violence. This violence is based on the social category (ethnic, religious, regional, national, gender, age, etc) that is ascribed to a particular group. It can be related to existing identities of this group, or it can be created by the authority or group in power. Because of belonging to a specific social category, a particular group can be denied some rights or access to resources and power (economic and political discrimination), to basic needs, including food (famine), territory (deportation), or right to exist (genocide). Members of a particular social group can experience exceptional hardship only because of their membership in this group that is perceived as treacherous, rebellious, or just secondary. | publication |
988923 | Homotopy theory of spaces of homomorphisms | In this project we propose to study homotopy theoretic properties of spaces of commuting elements in compact Lie groups. These spaces play an essential role in mathematical physics and geometry, but only in the last decade a systematic study by homotopy theoretic methods has been initiated. Important open questions in the field concern the homology as well as the (stable) homotopy type. In the first part of the project, we attempt to prove a conjectural stable splitting theorem, which would establish an intriguing relationship between spaces of commuting elements and commuting varieties in Lie algebras, an object of classical interest in algebraic geometry. In the second part, we propose to investigate the phenomenon of homology stability for spaces of commuting elements in the unitary and orthogonal groups. Building on recent work of the experienced researcher, an approach to calculate the stable homology is presented. This is expected to uncover a wealth of previously unknown homology groups of these interesting spaces.
The research conducted to achieve the project goals, together with the training in teaching and management received during the fellowship, will have a major positive impact on the career development of the experienced researcher. On the research level, this impact is through the acquisition of knowledge in new research areas, in particular in homology stability and the homotopy theory of Lie group actions.
The project will be carried out in an exceptionally active and successful scientific community at the University of Copenhagen, supervised by a world expert in the homotopy theory of Lie groups. Completion of the project will serve as a springboard to build new collaborations and to enter further advanced projects in a range of areas. It is thus a perfect preparation for a high-level research career in mathematics. | project/european |
218808 | Bioresorbable ostheosynthesis implant | In the EU, 20 % of all hospital treated injuries are bone fractures. If surgical treatment of bone fractures is necessary, it is currently performed with standard metal implants. Conventional gold-standard titanium or steel implants are too stiff, have adverse effects on the patient (feeling of pain during temperature changes) and lead to stress-shielding. Their usage is associated to the risk of infections and bone loss. Often a secondary surgery for removal is needed which is associated with almost 50 % higher healthcare costs. When Mg-based implants are used they are frequently alloyed with rare earth elements, aluminium, silver or zirconium. However, zirconium reduces the healing properties, aluminium and rare earth elements may remain in the organism and can lead to unpredictable effects, while the application of silver might result in a silver-disease.
Within the BRI.SCREW project we will introduce to the market revolutionary osteosynthesis implants that do not need surgical removal. We will use our own bioresorbable magnesium alloy which consists merely out of extremely high purified natural materials including Mg, Ca and Zn. BRI.SCREW is 100 % biodegradable, stimulates the healing process of the bone and has no side effects due to the implant's composition. Our orthopaedic implants will prevent the need of a second operation to remove the implant and will therefore minimize patient costs and surgical risks.
Our team consists of highly qualified individuals with experience in medicine, engineering and quality assurance. The investment in BRI.SCREW will pay off. We have estimated that after 5 years from launch, we will sell in total 81.900 BRI.SCREWs (sales €13.2M), hire 10 technical employees, and manage 5% of the global market. We will earn €8.7M profit and generate a ROI of 3.95 by commercializing this technology. We foresee the payback time in 2 years after commercialization (in Q3 of 2020). | project/european |