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Astrogeographical position for the Capital of North Korea Pyongyang for morphogenetic field level 1 which defines the international, supraregional topics, energetical situation and resonance of the North Korean government: the resonating degrees that define the international role and position of North Korean governments are 21° in highly magnetic, centralistic, royal fire sign Leo and 9° in highly alert, dynamic male fire sign fire sign Aries the sign of speed, action, ignition and warfare.
The role of self centered Leo the sign of the sun and the absolutistic appeal of rulers can be interpreted as an aspect that supports the extremely centralistic, royalistic dictatorship of the Kim Il-sung family over the country since its foundation in 1948. The combination of Leo with Aries the sign of quick action and warfare can be concluded to support the unwillingness of the “royal” family to compromise through sharing power with other institutions. Together with several Arab countries North Korea remains one of the few countries on the planet where qualification for political rulership by birth is still practiced. The most important country here is Saudi Arabia with its capital Riyadh having both astrogeographical coordinates in Leo one of which lies on 21° Leo and exactly on the same degree as Pyongyang. A different and in this context maybe surprising example of the dominant role of the presidential office over the democracic institutions and the people`s concerns is the USA whose capital Washington has one coordinate at 27°Leo.
The proclamation of the People´s Republic of North Korea saw a Mercury – Neptune conjunction opposite the 9°Aries astrogeographical position of its capital Pyongyang and of its government. That really challenging and weakening transit reflects the fact that the decision of the WW2 allies to divide the country into two halves along the 38th parallel had left it in a highly dependent position. That conjunction being in Libra the sign of chinese culture reflects the fact that apart from the strong influence of the USSR North Korea played also an important role for the chinese sphere of interest ever since its foundation. And it is a clearest hint the hidden and indirect influence and manipulation of North Korean politics through the influence from Beijing.
Chiron the ruler of strategical planning (Virgo) on 20°Scorpio occupied the exact square position to Pyongyang`s 21° Leo astrogeographical position in an aspect of high tension which reveals the economical dependence and the tight situation of a country that was stuck between the communist and capitalist global players.
Kim Il-sung the founder of the ruling dynasty of the Kim`s in North Korea was made Supreme Commander of the Korean People’s Army on 4 July 1950 which made him the most powerful person in the country with Mars at 9°Libra in opposition to Pyongyang`s 9°Aries position a transit which explains the heavy violent threat exerted onto Pyongyang by the Russian supporters of Kim Yong Un. This pressure is even more strongly emphasized by the conjunction of the Sun at 11° Cancer and conjunct the astrogeographic position of Moscow (12°CAN) together with the Uranus (5°CAN) – Mercury (3°CAN) conjunction.
Kim Jong-il (born 16. Februar 1941 in Wjatskoje, USSR) was made the Supreme Commander of the Korean People’s Army on 9 April 1993 with a Moon-Pluto conjunction at 25° Scorpio in a position 4° past the exact square to the 21°Leo astrogeographic position of Pyongyang.
Kim Yong-un the current dictator and son of Kim Jong-il was inaugurated on 29 December 2011 with an exact Sun and Pluto conjunction at 7°Capricorn approaching the exact square position to Pyongyang`s 9°Aries astrogeographical position. The constellation reveals the extreme pressure, hierarchy and threat exacted by the person of Kim Jong-un onto the capital and the country.
While I`m writing this article in March 2017 Uranus at 22°Aries is finally moving away from the exact trine to the 21°Leo astrogeographic position of Pyongyjang which appears to have triggered the boosting of and boasting with the country`s program for developing and testing missiles during the last 2 years or so.
The next really important period will be Uranus` transit in a square to the Pyongyang 21° Leo position between April 2023 (18°Taurus) and March 2025 (24°Taurus). This transit represents the most intense challenge to the North Korean government as the support from the Chinese and Russian allies is in question through Uranus in Taurus. As the ruler of Aquarius Uranus transit through Taurus stands for the urge of larger parts of society to participate in the country`s economical development and growth.
Neptune`s transit over the 9°Aries position of Pyongyang is to be evaluated as regulative and strengthening for the country but weakening for the ruling class. This is partly because Neptune as the ruler of the 12th sign from Aries represents a factor not naturally easy to understand and even much less to be controlled from a point of view of a place in Aries. That transit will be initiated in April 2028 and be effective until April 2029. As in the case of Neptune´s transit conjunct the astrogeographical position of Berlin during WW2 the transit could accompany the extremest delusion of the population and even the intentional destruction of the country.
Saturn`s transit over 9° Capricorn the square position to Pyongyang is the next chance for the United Nations and particularly for China and Russia to come to a reasonable agreement with the North Korean government in regard of the limitation of its hyperaggressive foreign politics. The transit will be first triggered in March 2018 and be effective until January 2019.
Astrogeographical position for the Capital of South Korea Seoul for morphogenetic field level 1 which defines the international, supraregional topics, energetical situation and resonance of the South Korean government: the presidential area in Seoul is located at 28° in self-protective earth sign Virgo sign of strategical planning and optimal use of ressources and 23° in highly alert, dynamic, male fire sign Aries the sign of speed, action, ignition and warfare.
The astrogeographical position of the South Korean capital at 28°Virgo falls on the same degree as Berlin capital of Germany. Both countries were divided by the Iron Curtain between the socialist and capitalist global spheres after WW2. Another parallel is the extreme economical growth both contries experienced since their foundations in 1948 and 1949 respectively.
The foundation of the Republic of Korea in South Korea was accompanied by a conjunction of the Sun at 22°Leo with Mercury and Saturn at 25°Leo in a highly stimulative and harmonious trine to Seoul`s astrogeographical position at 23°Aries. The Mercury-Saturn conjunction the clearest aspect of separation, rejection and divorce stood for the decision to leave the option of a unification of the two Korean occupation zones and the Korean nation behind. In addition Jupiter`s trine position to these highly stimulative aspects from 19° Sagittarius was a highly promising factor pointing at the huge potentials for economical growth that led to the Miracle on the Han River.
The reason that I`m writing this article in March 2017 is that the US has just started deploying their advanced Thaad Antimissile System in South Korea after the newest South Korean missile demonstration of 4 March 2017. The missile demonstration was apparently carried out to emphasize the country`s strength in a situation of high tension between North Korea and Malaysia after the murder of Kim Jong Nam by North Korean agents in Kuala Lumpur on 13 February 2017. This tense situation comes during the transit of Uranus over Seoul and shortly before Pluto`s square to the capital`s astrogeographic position at 23° Aries.
Uranus is currently in the process of transiting the 23°Aries astrogeographical position of the South Korean capital. This transit of reorganization and self finding was initiated in May 2016 and will last until February 2018. The mounting pressure exerted by the North Korean government on the South Korean borders,Japan and the USA with the threat of their nuclear weapons systems coming particularly during the transit of Uranus over the capital has several effects: First of all it “steals” the Uranus aspect of self.emancipation within the country`s own society by the pressure exerted from abroad. Such pressure allows little space for a revolution or self-finding process within the South Korean society. Secondly it provides the scenario and most intense danger of a nuclear war one could imagine. Wether or not we believe that Uranium and radioactivity are direct analogies of Uranus it is a fact that Uranus` transit over Seoul is accompanied by a new climax of threat of a nuclear strike by North Korea.
Pluto`s transit over 23° Capricorn and in a square to Seoul`s astrogeographic position at 23°Aries will be first triggered between March and May 2018 when Pluto reaches 21°Capricorn. After a retrograde phase it will be effective from January 2019 until January 2022. Pluto`s transit in Capricorn the 10th sign and house from Aries stands for a situation in which the South Korean government can be expected to be under pressure through the Pluto aspects of the North Korean government as reflected in the Sun-Pluto conjunction during the Kim Yong-un inauguration. Generally Pluto in the 10th house stands for inevitable situations, foreign rule and the rule of dogma and propaganda to an extent that allows no space for self-determination. The climax of that Pluto transit will certainly be reached on the day of the Saturn-Pluto conjunction at 22°46 Capricorn in exact square to the South Korean government of 13 January 2020. The fundamental impact of that constellation will be even more intensified through the company of the Sun on 22° and Mercury on 23° Capricorn. But at the same time Mercury as the planet of negotiations and the Sun as the planet of life suggest the need and also the possibility to come to a stable agreement that allows a peaceful coexistence or else the unification of the two Korean Republics.
Astrological chart for the Fall of the Berlin Wall on November, 9 1989, 21:20 with Saturn conjunct Neptun at 10° Capricorn in direct opposition to the astrogeographic position of the german Capital at 10° Cancer and Jupiter at 10°Cancer conjunct the astrogeographic position. The Sun was conjunct Mercury and Pluto just as it will be during the “Korean Wall” Saturn – Pluto conjunction on 13. January 2020.
Really fascinating for me is that Jupiter at 9° Capricorn will be conjunct the exact position of the Saturn – Neptune conjunction during the Fall of the Berlin Wall on 9 November 1989 which marked the end of the Cold War in Europe while this healing transit of Jupiter over that position could mark the end of the Cold War in Asia too. The resonance with the 1989 Saturn-Neptune conjunction is also remarkable because it was the cycle of Saturn -Neptune conjunctions which marked the major steps in the development of communism right from the start of the Russian revolution to the Fall of the Berlin Wall.
The Singapur Deal The Singapur Deal compared to the Saturn – Pluto conjunction of 13 January 2020 which so strongly resembles the Fall of the Berlin Wall constellation of November 1989. I proposed the option of a Korean unification as early as March 2017 on the basis of my astrogeographical findings in my article:”The Astrogeographical Positions of Pyongyang and Seoul” The singapur Deal was signed with Saturn square to Pyongyang The Singapur Deal signed by US President Donald Trump and North Korean dictator Kim Yong Un on 12 June 2018 was prepared and signed during the square transit of Saturn to the astrogeographical position of Pyongyang at 9°Aries which acompanied the strongest ever sanctions against Pyongayang and Trumps politic to buy Russian and Chinese consent over the Korean situation which led to Pyongyang`s nearly complete isolation. It has to be assumed that the US President had to make a major deal with China and Russia the US enemies in the Korean war to buy their consent for his step to achieve a treaty with North Korea. The Moon position of the signing of the Singapur deal on the highly profitable degree of 29° Taurus stands for the economical cooperation between the 3 superpowers that made this deal possible. As this Moon position was exactly square the astrogeographical coordinate of Washington at 27°Leo the highest fincancial contribution must definitely have been guaranteed by the US government.
The coming Sun-Saturn-Pluto-Mercury conjunction of 13 January 2020 will take place right on the Pluto position of the Singapur deal at 20°Capricorn. This constellation may have an effect like a seal that could serve to stabilize the achievements of the Trump-Kim Singapur Deal.
|
{
"timestamp": "2019-04-19T01:25:06",
"url": "https://astrologicalworldmap.com/2017/03/08/the-astrogeographical-position-of-pyongyang-and-seoul/",
"language": "en",
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PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched in order to find randomized controlled trials evaluating the effect of ursodeoxycholic acid on lipid profile. A random-effect model and the generic inverse variance weighting method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A random-effects meta-regression model was performed to explore the association between potential confounders and the estimated effect size on plasma lipid concentrations.
Meta-analysis of 20 treatment arms revealed a significant reduction of total cholesterol following ursodeoxycholic acid treatment (WMD: − 13.85 mg/dL, 95% CI: -21.45, − 6.25, p < 0.001). Nonetheless, LDL-C (WMD: -6.66 mg/dL, 95% CI: -13.99, 0.67, p = 0.075), triglycerides (WMD: − 1.42 mg/dL, 95% CI: -7.51, 4.67, p = 0.648) and HDL-C (WMD: -0.18 mg/dL, 95% CI: -5.23, 4.87, p = 0.944) were not found to be significantly altered by ursodeoxycholic acid administration. In the subgroup of patients with primary biliary cirrhosis, ursodeoxycholic acid reduced total cholesterol (WMD: − 29.86 mg/dL, 95% CI: -47.39, − 12.33, p = 0.001) and LDL-C (WMD: -37.27 mg/dL, 95% CI: -54.16, − 20.38, p < 0.001) concentrations without affecting TG and HDL-C.
This meta-analysis suggests that ursodeoxycholic acid therapy might be associated with significant total cholesterol lowering particularly in patients with primary biliary cirrhosis.
The global prevalence of hypercholesterolemia among adults is still increased . Abnormal lipid levels, frequently accompanied by central obesity, high blood pressure and type 2 diabetes, have been clearly identified as a major risk factor for cardiovascular disease . Moreover, the high prevalence of overweight and obesity have led to the increase in lipid disorders . Given that pharmacological treatment may be insufficient to achieve the recommended goals for lipid concentrations, alternative lipid-lowering therapies are needed to reduce the risk of atherosclerotic cardiovascular disease [4, 5, 6, 7, 8, 9, 10, 11, 12].
Ursodeoxycholic acid is a primary bile acid formed in the human liver [13, 14]. This hydrophilic molecule has a low toxicity and is usually used at a pharmacological dose of 10–15 mg/kg/day [14, 15]. Ursodeoxycholic acid is widely prescribed in the treatment of several cholestatic liver diseases such as cholesterol-gallstone dissolution, primary biliary cirrhosis and cholestasis of pregnancy [16, 17]. Evidence suggests that the therapeutic effects of ursodeoxycholic acid are explained by an increased hydrophilicity index of the bile acid pool, stimulation of hepatocellular and ductular secretions, cytoprotection against bile acid and cytokine-induced injury, immunomodulation and anti-inflammatory effects . Additionally, some clinical trials have observed a significant decrease in total cholesterol levels after ursodeoxycholic acid treatment [18, 19, 20]; however, other studies found no beneficial effect of this bile acid on lipid metabolism [21, 22, 23]. Thus, the lipid-lowering activity of ursodeoxycholic acid is currently uncertain and remains to be elucidated. Therefore, the present meta-analysis of randomized placebo-controlled trials aimed to examine whether ursodeoxycholic acid treatment is an effective lipid-lowering agent.
This study was designed according to the guidelines of the 2009 preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement . In order to find randomized controlled trials evaluating the effect of ursodeoxycholic acid on lipid profile, PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched using the following search terms within titles and abstracts (also in combination with MESH terms): (ursodeoxycholic acid) AND (cholesterol OR “low-density lipoprotein” OR LDL OR LDL-C OR LDL-cholesterol OR “high-density lipoprotein” OR HDL-cholesterol OR HDL-C OR triglyceride OR hyperlipidemia OR hyperlipidemic OR dyslipidemia OR dyslipidemic OR lipid OR lipoprotein). The wild-card term “*” was used to increase the sensitivity of the search strategy. The search was limited to articles published in English language. The literature was searched from inception to June 06, 2018.
Original studies were included if they met the following inclusion criteria: (1) being a randomized placebo-controlled trial with either parallel or cross-over design, (2) evaluating the effect of ursodeoxycholic acid on plasma/serum concentrations of lipids, and, (3) presentation of sufficient information on lipid concentrations at baseline and at the end of follow-up in each group or providing the net change values. Exclusion criteria were: (1) non-interventional trials, (2) lack of a placebo group for ursodeoxycholic acid treatment, (3) observational studies with case-control, cross-sectional or cohort design, and (4) lack of sufficient information on baseline or follow-up (or net change) lipid concentrations.
Eligible studies were reviewed and the following data were abstracted: 1) first author’s name; 2) year of publication; 3) study design; 4) number of participants in the intervention and placebo groups; 5) dose and duration of treatment with ursodeoxycholic acid; 6) age, gender and body mass index (BMI) of study participants; and 7) circulating concentrations of lipids.
A systematic assessment of bias in the included randomized placebo-controlled clinical trials was performed using the Cochrane criteria . The items used for the assessment of each study were as follows: adequacy of random sequence generation, allocation concealment, blinding of participants, personnel, outcome assessment, not addressing dropouts (incomplete outcome data), selective outcome reporting, and other potential sources of bias. According to the recommendations of the Cochrane Handbook, a judgment of “yes” indicated low risk of bias, while “no” indicated high risk of bias. Labeling an item as “unclear” indicated an unclear or unknown risk of bias.
Meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V2 software (Biostat, NJ) . Effect size was calculated as: (measure at the end of follow-up in the treatment group − measure at baseline in the treatment group) − (measure at the end of follow-up in the control group − measure at baseline in the control group). A random-effect model (using DerSimonian-Laird method) and the generic inverse variance weighting method were used to compensate for the heterogeneity of studies in terms of study design, treatment duration, and the characteristics of populations being studied . All units were collated as mg/dL. Standard deviations (SDs) of the mean difference were calculated using the following formula: SD = square root [(SDpre-treatment)2 + (SDpost-treatment)2 – (2R × SDpre-treatment × SDpost-treatment)], assuming a correlation coefficient (R) = 0.5. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI). Inter-study heterogeneity was quantitatively assessed using the I2 index. In order to evaluate the influence of each study on the overall effect size, a sensitivity analysis was conducted using the leave-one-out method (i.e., removing one study each time and repeating the analysis) [28, 29, 30].
As a potential confounder of treatment response, treatment duration was entered into a random-effects meta-regression model to explore their association with the estimated effect size on plasma lipid concentrations.
Evaluation of funnel plot, Begg’s rank correlation and Egger’s weighted regression tests were employed to assess the presence of publication bias in the meta-analysis. When there was an evidence of funnel plot asymmetry, potentially missing studies were imputed using the “trim and fill” method .
Our initial search identified 795 published trials. After screening of titles and abstracts, 661 studies were excluded. Of these, 103 studies excluded for not meeting the inclusion criteria. Subsequently, 31 full-text articles were carefully reviewed for eligibility and 16 clinical trials were excluded for having no control group (n = 3), not presenting numerical values (n = 3), incomplete data on lipid parameters (n = 8), and treatment duration < 1 month (n = 2). Finally, 15 studies were selected and included in the present meta-analysis. The detailed study selection process is presented in Fig. 1.
Data were pooled from 15 randomized placebo-controlled trials comprising a total 1370 subjects, including 735 and 635 participants in the intervention and placebo arms, respectively. Included studies were published between 1977 and 2013. The clinical trials used different doses of ursodeoxycholic acid. The range of treatment duration was from 1 month [32, 33] to 2 years [18, 20, 23, 34, 35, 36]. Study design of included trials was parallel and cross-over. Selected studies enrolled subjects with primary biliary cirrhosis [18, 20, 21, 34, 35, 36, 37, 38], primary hypercholesterolemia , hypertriglyceridemia , gallstones [23, 37], nonalcoholic fatty liver disease (NAFLD) [19, 39], nonalcoholic steatohepatitis (NASH) , and healthy volunteers . Characteristics of the included clinical trials are shown in Table 1.
According to the Cochrane criteria, most of included studies showed insufficient information about random sequence generation and one study had a high risk of bias . With respect to allocation concealment, several trials exhibited limited information. Regarding blinding of participants, personnel and outcome assessors, several studies revealed lack of information and one trial presented high risk of bias . Finally, all the evaluated trials had low risk of bias for incomplete outcome data and selective outcome reporting. Details for the risk of bias assessment is presented in Table 2.
Meta-analysis of 20 treatment arms revealed a significant reduction of total cholesterol following ursodeoxycholic acid treatment (WMD: − 13.85 mg/dL, 95% CI: -21.45, − 6.25, p < 0.001). This effect size was robust in the sensitivity analysis (Figs. 2 and 3). Nonetheless, other lipid indices including LDL-C (WMD: -6.66 mg/dL, 95% CI: -13.99, 0.67, p = 0.075), TG (WMD: -1.42 mg/dL, 95% CI: -7.51, 4.67, p = 0.648) and HDL-C (WMD: -0.18 mg/dL, 95% CI: -5.23, 4.87, p = 0.944) were not found to be significantly altered by ursodeoxycholic acid administration (Figs. 2 and 3).
In patients with primary biliary cirrhosis, ursodeoxycholic acid reduced total cholesterol (WMD: − 29.86 mg/dL, 95% CI: -47.39, − 12.33, p = 0.001) and LDL-C (WMD: -37.27 mg/dL, 95% CI: -54.16, − 20.38, p < 0.001) concentrations without affecting TG (WMD: 11.24 mg/dL, 95% CI: -1.15, 23.62, p = 0.075) and HDL-C (WMD: -3.27 mg/dL, 95% CI: -8.75, 2.22, p = 0.243) levels (Fig. 4).
Meta-regression analysis revealed that the effects of ursodeoxycholic acid on total cholesterol (slope: − 1.51; p < 0.001), LDL-C (slope: − 1.97; p = 0.001) and TG (slope: 1.38; p = 0.004) but not HDL-C (slope: − 0.23; p = 0.482) concentrations were associated with treatment duration (Fig. 5).
Publication bias assessment revealed asymmetric funnel plots and evidence suggestive of bias. This asymmetry was corrected by imputing potentially missing studies using “trim and fill” method (Fig. 6). Egger’s regression test suggested the presence of publication bias in the meta-analyses of total cholesterol (p = 0.008), LDL-C (p = 0.003) and HDL-C (p = 0.026). Begg’s rank correlation test suggested the presence of publication bias only in the meta-analysis of LDL-C (p = 0.024).
The present meta-analysis of randomized placebo-controlled trials examined whether ursodeoxycholic acid treatment might be an effective lipid-lowering agent. Indeed, this meta-analysis revealed a significant reduction in total cholesterol levels following ursodeoxycholic acid therapy (− 13.85 mg/dL), but the rest of parameters of lipid profile were not significantly changed.
In consistency with our findings, several clinical trials have found a significant reduction in total cholesterol concentrations after ursodeoxycholic acid administration [18, 19, 39, 40]; however, the potential mechanisms involved in the cholesterol-lowering effects of this bile acid have not been clarified. In this regard, it has been proposed that ursodeoxycholic acid may decrease the cholesterol biosynthesis by reducing the activity of hydroxymethylglutaryl-coenzime A reductase [41, 42]. Also, ursodeoxycholic acid decreases the dietary cholesterol absorption lowering serum cholesterol levels . Additionally, it has been proven that the administration of ursodeoxycholic improves hepatic function through increasing the synthesis of bille acid, cholesterol and steatosis, and decreasing the activity of farnesoid X receptor (FXR) .
Experimental data suggested that ursodeoxycholic acid has also the ability to protect the cholangiocytes against hydrophobic bile acids by simultaneous decrease of the concentration of hydrophobic bile and reduction of the bile acid cytotoxicity . Besides, it has been reported that this pharmacological agent increases hepatic LDL uptake through a direct interaction with the LDL receptor . Furthermore, ursodeoxycholic acid was reported to be able to change the hydrophobicity index of the bile acid pool [47, 48]. Ursodeoxycholic acid may improve the cell resistance to reactive oxygen species, to decrease the permeability of the mitochondrial membrane and to inhibit release of hydrolytic enzymes from damaged hepatocytes [49, 50]. Moreover, some important genes involved in lipid uptake (Cd36 and Ldlr) and hepatic lipid synthesis (PPARG, Chrebp-a/−b, Acaca, Fasn, Me1, and Scd1) seems to be modulated by ursodeoxycholic acid, as mecanisms of protection against hepatic fat accumulation . Ursodeoxycholic acid may also influence the adipose tissue through increasing triglyceride levels, and increasing the esterification and desaturation of fatty acids .
Of particular interest is the clinically relevant decrease in TC and LDL-C specifically observed in primary biliary cirrhosis patients. This could be of particular interest given the increased coronary artery disease risk observed in patients affected by this condition .
There are some limitations of this meta-analysis that deserve to be mentioned. First, the lipid-lowering action of ursodeoxycholic acid was not the primary outcome in almost all selected studies; hence, further clinical trials are needed in order to corroborate the hypolipidemic effect of this acid bile as primary endpoint. Second, several studies included in this meta-analysis presented insufficient information with respect to the quality of bias assessment suggesting caution in the overall quality. Third, although the selected studies were heterogeneous in terms of target population and characteristics, we tried to minimize the inter-study heterogeneity using a random-effects model. Finally, most of the trials assessed were performed on small sample sizes resulting in a limited pooled population in the overall analysis.
Data from this analysis are available through collaboration under a data usage agreement with the corresponding author.
LE-M, MS-M and AS contributed to the conception of the study. LES-M, MS-M and AS-G carried out the literature search and data abstraction. AS performed the statistical analysis. LES, MS and AS wrote the manuscript. M-CS, MB, AFGC revised the draft and helped with interpretations. All authors approved the final manuscript.
Dr. Banach has served on speaker’s bureau and as an advisory board member for Amgen, Sanofi-Aventis and Lilly. Other authors have no conflict of interests to disclose.
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{
"timestamp": "2019-04-25T13:47:32",
"url": "https://link.springer.com/article/10.1186%2Fs12944-019-1041-4",
"language": "en",
"source": "c4"
}
|
With the NFL Super Bowl coming up and the Jazz on a hot streak, it's an excellent time to check out one of the Salt Lake area's favorite sports bars. There's something about watching the big game on the big screen, with great friends and great food and drink, that you just don't get at home. Click on the link below for a list of SLC sports bars, and enjoy the game!
Photo by Digital Vision. Read more from Marsha Maxwell at http://saltlakecity.about.com/.
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{
"timestamp": "2019-04-21T06:12:57",
"url": "https://www.visitsaltlake.com/blog/stories/post/slc-sports-bars/",
"language": "en",
"source": "c4"
}
|
The search for "OK1IKN" produced no results.
OK1IKN looks like a callsign from Czech Republic (DXCC Entity #503).
Would you like to add OK1IKN to the database?
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{
"timestamp": "2019-04-20T17:03:12",
"url": "https://www.qrz.com/db/OK1IKN",
"language": "en",
"source": "c4"
}
|
If you’re like most people, you haven’t put a great deal of thought into creating your password. In fact, it’s probably a short, easy-to-remember password that you use for most of your accounts. Maybe it’s your son’s name and date of birth, a favourite hobby or a number sequence. That’s fine when you consider the average person will struggle to guess what your password is, but for a hacker that’s not the case.
Passwords are your last defence against the prying eyes of a hacker, so making your passwords safe is of utmost importance if you won’t want your personal information or online activities exposed.
How can your password be compromised?
If someone wants to take a squiz at your personal life and your password is weak, then cracking into your e-mail account may be relatively easy. And if they don’t get it after a couple of attempts, your password recovery questions are likely to be easy to answer if the person knows you well.
Hackers often use brute-force tactics or professional hacking software to access multiple user account or just individuals. Software will quickly break into an online account with a weak password. Brute-force attacks on the other hand requires hackers to systematically check all possible passphrases until they stumble upon the correct one.
Hacking or leaking data from big companies is becoming a more common occurrence. In these cases, millions of customers’ account information is leaked and as a result compromised. Vodafone Australia recently reported a security breach as did the affairs website, Ashley Madison (slightly ironic, don’t you think?).
In the event your data is leaked through the security breach of a large company, there is really nothing you can do about it regardless of how strong your password is. However, you can protect yourself from brute-force hacking or from the prying eyes of curious friends and frenemies. The only way is to create a strong, complex password. A strong password should be at least 16 characters. It should comprise of a combination of upper and lowercase letters, numbers, and symbols or spaces.
Avoid using patterns like 123abc123, dictionary words, usernames, IDs, personal info or sequences of numbers and letters. And you should have a different password for each of your online accounts.
Password strength is evaluated by the “bit” content. The higher the bits in your password, the stronger it is. A 60-bit password for example, would take much longer to crack than a 20-bit password.
The downside of making your password secure is that they’re an inconvenience. How likely are you to remember a 16+ character password that has a security strength of 60-bits for each of your accounts? You’re not. That’s why you should consider using a password manager. LastPass, KeePass and Google Chrome’s password manager are just some of the popular websites out there that can store your passwords online. You just need to remember one strong password to access it!
If your struggling to replace your existing password with something more complex, a password generator may come in handy. Most password managers, like the ones listed above, will usually have their own reliable password generator tool for you to use.
If you want to come up with one on your own, think about creating a phrase. For example, you can use the phrase “I want the All Blacks to take out the 2016 Rugby Championship!” and simply make your password a combination of all the letters, numbers and symbols. Using this phrase your password would be: IwtABttot2016RC!
Once you have decided on a complex password, Microsoft and Apple now offer users an online password strength checker to ensure your chosen combination won’t be easily cracked.
When setting up accounts that use a “two-step verification” system make sure you enable it, even if you have a strong password. This will require you to enter a code that is sent as a text to your phone, which may sound annoying but it means if a hacker doesn’t have your phone, they won’t be able to sign in.
In January this year, Google made big strides in implementing their vision of a more secure web, through a new feature in their Chrome version 56 release, that highlighted sites that didn’t use a secure HTTPS connection.
Many organisations overlook the security of their domain name when they are developing or reviewing their security policies.
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{
"timestamp": "2019-04-20T05:08:09",
"url": "https://www.freeparking.co.nz/blog/password-security-and-size-is-important-keys-to-making-your-password-safe/",
"language": "en",
"source": "c4"
}
|
Below are weather averages from 1971 to 2000 according to data gathered from the nearest official weather station. The nearest weather station for both precipitation and temperature measurements is ARTICHOKE L which is approximately 12 miles away and has an elevation of 1,075 feet (60 feet lower than Chokio Cemetery). Because the nearest station and this geographic feature may have differences in elevation and topography, the historic weather at the two separate locations may be different as well.
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{
"timestamp": "2019-04-24T16:16:10",
"url": "https://www.anyplaceamerica.com/directory/mn/stevens-county-27149/cemeteries/chokio-cemetery-641178/",
"language": "en",
"source": "c4"
}
|
RFI allocates the railway network capacity according to the rules and deadlines set in the Network Statement, and also in compliance with principles of transparency, fairness and non-discrimination.
The network use can be requested from Railway Undertakings in terms of train paths, and services, referred to the current timetable period or to the next year one.
To require both train paths national and train paths international: AstroIF (access to authorized users) .
The RU may use each channel available (Though the above channels can be used), but path request for a train must be submitted by one channel only.
The start-up of train paths allocation process for the timetable 10th December 2017 – 8th December 2018 is scheduled for April 11th, 2017.
|
{
"timestamp": "2019-04-23T20:53:36",
"url": "http://www.rfi.it/rfi-en/Railway-infrastructure-access/Train-paths-application",
"language": "en",
"source": "c4"
}
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Awesome stuff, Anton. Gee, those 17th Century ships have something uniquely attractive about them. As an aside, I note that you're planning to build the Batavia later. As a WA local, that would really interest me. Is there a kit available? Or maybe a scratch build?
Gee, that's looking good, Scott. A pleasure to view. Have you made a decision about finishing the lower hull? A lot of Friesland modellers have painted it white. I really like the natural finish, though.
Good luck with the build, Scott. Looking forward to this one. Always liked the look of those 17th Century ships.
|
{
"timestamp": "2019-04-26T10:26:26",
"url": "https://modelshipworld.com/profile/390-granta/",
"language": "en",
"source": "c4"
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Christmas (1968). Scott and Craig with their Christmas toys (cowboy outfits, fishing rods, and chinese checkers). View Larger Size from Flickr.
1961. I know all of you were dying to know what table sugar (sucrose) looked like under a microscope, so here it is. This slide is from one of dad's sophomore-year high school projects. Sorry there isn't a people picture tonight. It must be the geek in me but I think it looks pretty cool. View Larger Size from Flickr.
San Diego, CA (1975). Mom and Kenneth. This is one of my favorites so far. I am pretty sure this was taken at Sea World because this slide was surrounded with pictures of killer whales and dolphins. Oh, and did you notice mom's wig? View Larger Size from Flickr.
Dad's High School Graduation (1963). This one was among some of the oldest slides I've scanned yet. I feel like I should submit it to some historical society or something :-P. View Larger Size from Flickr.
Grand Targhee (1995). This is from our family reunion in the Tetons so just about all of our cousins are in the photo. It was also shortly after we adopted Hanah. View Larger Size from Flickr.
Arizona (1976). Kenneth napping during some cartoons (hence the slight glow of the TV reflecting on his face). Based on one of the other scanned slides, it looks like it was a cartoon with Pepe Le Pew. View Larger Size from Flickr.
Saltzburg, Austria (1986). Yeah yeah, I know...that minor joke is overdone. Anyhow, I thought this was a great picture of Eden in her salt mine outfit. View Larger Size from Flickr.
I'm back. Sorry for the lack of posts recently. I didn't have access to all of the pictures during the Thanksgiving break. I need to get back to posting a picture a day..so here is one of Naomi.
Colorado, 1978. Mom says she thinks Naomi was trying to hold something in her shirt. This slide was taken on the same trip as the 'Independence Pass' picture that I already posted. View Larger Size from Flickr.
|
{
"timestamp": "2019-04-20T10:15:02",
"url": "http://blog.pausitiv.com/2008/",
"language": "en",
"source": "c4"
}
|
Aletha - Done no update.
Well i'm impressed, somehow this turn is more exciting than last turn!
Story and map up. I will be updating all team results with them tomorrow.
Thanks again to Naagi and Voice for the help.
IC threads are all going up now for teams.
|
{
"timestamp": "2019-04-24T14:00:38",
"url": "http://shards.eu/viewtopic.php?f=4&t=167&p=1312",
"language": "en",
"source": "c4"
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|
Description: Wedding Backgrounds 2427 from the above 1920x1200 resolution which is part of the BackgroundsImagesPicturesWallpapers category. Download this image for free in HD resolution the choice "download button" below. If you do not find the exact resolution you are looking for, then go for a native or higher resolution.
|
{
"timestamp": "2019-04-19T08:23:44",
"url": "http://informationcommunicationtechnology.com/wedding-backgrounds-2427/",
"language": "en",
"source": "c4"
}
|
Howdy, I'm upgrading from my home theater from a sony HIB and looking at polk speakers. Im sticking around a grand for receiver and speakers. So naturally im looking at the complete T-series set up with an onkyo tx nr757. But on Amazon I saw a onkyo tx nr656 with polk TSi speakers bundle that fit my budget as well...Which speaker line is better TSi or The t-series? I cant seem to find much info out there to compare the 2 lines.
The Polk line is this.
This bundle has the tsi300 tower...the receiver is slightly less than what the 757 provides but 150 bucks more for the tsi package vs the T series with a slightly better receiver. I guess are the tsi300 worth more compared to the t50? Or would you really not even notice the difference much? Too many options out there and it's rather annoying. Haha at least in my price range.
For my use the T series work great in a workshop environment and the sound is satisfying. Not a big deal if they get beat around, scratched, dusty, etc.
From experience the Signature are a significant improvement in sound quality. Everyone who's listened to S20 bookshelves is pleased. In comparison to the older design Monitor towers, they're just better overall, except for lacking the low end. Signature towers provide a full range for music.
Can't compare to TSi line as I've no experience.
Yeah, the Sigs are a pretty nice speaker.
The TSI have a better build quality than the T series. I think they look better also, but that is the reason the cost more. Both are designed for people just getting into HT, or as in your case, moving up from HTIB systems.
Whichever you choose will probably be an improvement to most HTIB systems.
This is the bundle I was talking about.
Or go T series but still in the air on receiver.
Why have you settled on Onkyo for the receiver?
Personally, not a fan of their sound or build quality.
Have you looked at any of the Yamaha options?
Not a bad system for the price. Think you'll like it better than your HTIB system.
You'll need speaker wire, a subwoofer cable, and HDMI cable(s) to get everything up and running. Check Blue Jeans cable for budget friendly speaker cable. Would recommend Audioquest's Forrest HDMI cable, may seem a little pricey to you, but the little extra is well worth it.
I always heard good things about Onkyo but the 656 actually has a lot of complaints. I stayed with Onkyo solely to chop the field down as I was overwhelmed with all that was out there.
I have not looked at Yamaha but my BIL has a Yamaha receiver and loves it. So back to the drawing board.
I think the advice about the Onkyo is worth heeding. They pack a lot of features for the money in their receivers and something has to give. They do have a history of HDMI board failures. Maybe they fixed that? I don't know. Yamaha has always been a solid value even when other mainstream brands have gone soft. I recently purchased a Pioneer with class D3 power and I like it. I used to think poorly of Pioneer but this Elite SC-99 is a keeper. Especially with M-65's driving my mains.
As for speakers, I like your choice. There was a period of time right after the 80's when Polk disappointed a bit but the new ones sound pretty remarkable when paired with a sub.
If you want to build your own system, you can get all the speakers on the Polk E Bay site, except the center channel. I'd recommend substituting the sub with the PSW 505, it's just a better sub. The CSI10 can be bought off Amazon.
Go to the Accessories4Less website for the AVR. There factory refurbished, but I personally haven't had any problems/issues with anything I've bought from them.
Looks like it will come out about the same price as the bundle you looked at.
It's true that Onkyo's is having issues with their HDMI boards, but I personally have an issue with their AccuEQ calibration program they use. The board can be replaced, the calibration program can't.
The problem is the receiver I cant seem to find much about and compare to the Onkyo nr656. Ill have to research some, my plan is to stay around 1200 but no more. I have to upgrade my screen as well so have to save some cash for it. Going from a 100" manual pull down to a Wife requested 125" electric tab tension. That will be the max size able to fit in our spot. This is in a bonus room above a garage so its not all that big.
WHOA. 'Wife requested 125"' screen? I guess size matters to women after all! My Wife doesn't want to see any electronics or speakers. Lucky you.
Honestly I would get the Yamaha packages over the Onkyo any day. I would try to push for the RX-A760 more, $200 more and a lot better system.
Actually, Yamaha, Denon or Marantz are all good choices as well. You might scoff, but Pioneer Elite and Sony ES will more than give them a run for their money.
I really am! She could likely go without the audio but she wants the bigger screen. So....Im gonna do both, then set the room up like an actual theater with a riser and two rows of seats. I hope it all comes together!
Im scared on the audio though. Spending that much and she cant tell a difference from it and the HTIB we have been using. She is not big on super loud and thunderous but I am.
Ill see what kind of deal they can work on that other system. It is starting to get on up there though and next thing you know Ill be rocking the latest Klipsch..hahaha There is always that next best speaker. I just want a good sounding system for a dedicated smallish theater. But if they can quote me the better package for 1200 or really close I can go that way.
The biggest considerations are power and features. You will hear the effects of too little power and likely blow your speakers. Also make sure you get the essential features like the latest 4K connectivity and surround options. Avgoodnroom correction feature is good to have.
And make sure it's a reliable brand.
The Yamaha RX-V series AVR's are Yamaha's entry level series of AVR's. Very good build quality in their price range.
Check Crutchfield. You can compare both of those AVR's, side by side on their site.
I understand the limited budget. Yamaha is about the best budget AVR you can get. That is why I didn't recommend Marantz or Denon.
As for speakers Both the packages above have the same speaker setup. If you can find a Signature package jump on it.
I agree these are good units but the cost is out of the OP's budget.
Have to go to a few websites, but within your budget.
Moving up from HTiaB, you should love this setup and it's around your budget. You can jump down the rabbit-hole later and enjoy this now. Seems like a great deal.
Your other option is looking on your local Craigslist for speakers. Where do you live?
North Mississippi...Craigslist is about worthless here. hahaha Even in surrounding areas it is not that good.
Pioneer Elite for your AVR.....done.
This is what I would get, and then start saving money for SVS sub.
|
{
"timestamp": "2019-04-26T14:38:15",
"url": "https://forum.polkaudio.com/discussion/comment/2347864",
"language": "en",
"source": "c4"
}
|
Rinse kidney beans and then push through a colander.
Whisk together eggs, all purpose, salt, spices, and beans together until there is no clumps.
Heat a sauté pan with about a tablespoon of olive oil on high heat. When pan is hot place a tablespoon of the bean mixture into the pan. Sear on both sides until golden brown.
Serve with spaghetti and tomato sauce.
|
{
"timestamp": "2019-04-23T04:50:07",
"url": "https://www.kellyschoice.org/bean-meatballs/",
"language": "en",
"source": "c4"
}
|
Find the best Recruiting / HR Events for across the whole globe.
Are you a conference or event organiser?
Add your event to the Big List!
Do you need to find a speaker?
|
{
"timestamp": "2019-04-18T22:34:50",
"url": "https://www.recruitingbrainfood.com/list-of-events-2019/?utm_campaign=Hung%20Lee&utm_medium=email&utm_source=Revue%20newsletter",
"language": "en",
"source": "c4"
}
|
To me this is a classic case of getting three good years from someone else's recruits. The only conclusion I have come to with Fridge is that he is a great coach but he can't convince the best players to come to maryland.
That's the knock on Fridge, he can coach em, can't recruit em.
Hiiiiii this is the great web site please go through it!!!!!!!!!!!
|
{
"timestamp": "2019-04-22T14:27:15",
"url": "http://www.terpsnation.com/2008/09/your-football-team-might-stink-if.html",
"language": "en",
"source": "c4"
}
|
Jessie was the child of a family of Black-Cloth Shrine’s believers, and he demonstrated talent in cultivating holy power since a young age. Black-Cloth Shrine paid attention to him since he was four years old, and he was taught by elders in the shrine such as Batistuta and Totti. He was taught the code of the Black-Cloth Shrine, and he tightly measured his actions and words according to the code.
Therefore, you could say that Jessie was a person who held others to high standards, but his standards for himself was even higher.
Therefore, having a wild [God Favorite Child] like the King of Chambord to become the bishop of Black-Cloth Shrine was too much for him to take in at once. Even though people like Batistuta tried to open his mind, but he still couldn’t accept it that easily.
However, he had to listen to the orders of the elders.
Besides, the oracle stated that the [God Favorite Children] had the qualification of becoming bishops of the shrines. The only thing that confused Jessie was that why did the gods choose the King of Chambord, who never behaved according to the code of the Holy Church, as a [God Favorite Child].
To Jessie, the conflict in terms of beliefs felt worse than losing his life.
As the young priest was still bothered by his thoughts, the warriors of Chambord such as Drogba and Pierce were swearing and insulting Andrew Arshavin, Zenit’s God of War who was being loved by the people in the empire.
“Humph! F*ck that man; he is only a con artist! If the five main battle legions were given to His Majesty, His Majesty would be able to conquer the Spartax Empire and the Eindhoven Empire easily. After all, there are 150,000 elite soldiers there!” Drogba said ferociously as he bit into the delicious roast boar leg in his hand. He was furious, and he was calling Arshavin names.
“You are right! Alexander His Majesty is able to stop for 70,000 elite soldiers of Jax for 40 days with a legion that is recently made. He even killed a powerful master called [Snow Mountain Hermit] and suppressed all the masters who were there for the Mythical Palace. Can he, the Crown Prince, do it?” the other tough man of Chambord, Pierce, also raised his voice and shouted.
“Humph! I heard that Crown Prince Arshavin let his subordinates handle the southwest battle zone, and he went back to the Capital; he is planning to use this victory momentum to fight for the throne with Dominguez His Highness. People are saying that he accused Alexander His Majesty of prolonging the war, ruling the Dual-Flags City like an emperor, killing nobles of Zenit, and secretly getting in touch with the enemies of Jax……” Torres said. After hearing all kinds of rumors recently, he who was usually calm couldn’t hold back as well.
“I heard that the situation at St. Petersburg is a mess; almost all the nobles are supporting the Crown Prince. Under the planning of the Elder Princess, Arshavin is pretty much in control, and the Second Prince is in danger; he experienced quite a few assassination-attempts now already.
The discussion soon got out of hand, and all sorts of treasonous things were said.
At this moment, a person slowly walked by and dried coughed to get their attention.
The person speaking was the strategist for Chambord, Old Aryang.
A filler chapter turns into 10.
|
{
"timestamp": "2019-04-22T16:07:49",
"url": "https://www.noodletowntranslated.com/hail-the-king/hail-the-king-chapter-560-1/",
"language": "en",
"source": "c4"
}
|
Your Office away from home!
Welcome to Ridgefield Professional Offices, your office away from home!
When you need an office space for a meeting, we have 2 beautiful rooms available to rent by the hour or by the day.
We are proud that our offices are wheelchair accessible.
An executive board room, 15 feet by 10 feet, with a board table, comfortable chairs, conference phone and office services. Ideal for meetings for 6 to 8 people.
Our largest room, 20 feet by 18 feet and contains a large conference table and two desks. Our conference room features a 54 inch HD flat-screen TV that is PC and/or HDMI compatible.
Our location at 35 Danbury Road, Ridgefield CT 06877.
|
{
"timestamp": "2019-04-21T13:00:55",
"url": "http://ridgefieldprofessionaloffices.com/",
"language": "en",
"source": "c4"
}
|
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