RJuro/neuro_patents · Datasets at Hugging Face

appln_id int64 7.41k 576M	appln_filing_date stringlengths 10 10	docdb_family_id int64 3.49M 82.2M	granted stringclasses 2 values	appln_abstract stringlengths 120 10k	appln_abstract_lg stringclasses 1 value	appln_title stringlengths 4 567	applt_coun stringlengths 4 289	invt_coun stringlengths 8 347	cpc stringlengths 11 1.62k	ipc sequence	__index_level_0__ int64 25 167k
523,340,322	2019-05-22	66,867,788	Y	Described are methods of modulating the activation of the TRPV1 ion channel by administering at least one cannabinoid and/or terpene compound.	en	TRPV1 activation-modulating complex mixtures of cannabinoids and/or terpenes	72250102_CA	56967828_US,11528936_US	A61K 31/01,A61K 31/015,A61K 31/045,A61K 31/05,A61K 31/352	[ "A61K 31/05", "A61K 31/352", "A61K 31/01" ]	134,830
437,152,693	2006-11-09	52,473,077	Y	Improvements in magnetic resonance imaging methods to obtain three-dimensional models and diagnoses of Thoracic Outlet Syndrome are described.	en	Method to evaluate patients for thoracic outlet syndrome	50026655_US,50010614_US	50026655_US	A61B 5/004,A61B 5/02007,A61B 5/055,A61B 5/7282,A61B2576/00,G16H 30/40	[ "A61B 5/05" ]	91,942
444,302,596	2010-05-13	43,085,579	N	Disclosed is an antibody which binds to CD53 comprising the CDRs GFTFSDAWMD, EIRNKAKNHATYYAESVKG, TTLDS, KSSQSLLDSDGKTYLN, LVSALDS, WQGTHFPWT.	en	Anti-human cd52 immunoglobulins	5221479_	43642437_,47647322_,38533831_,37226327_	A61K 39/395,A61K2039/505,A61P 9/00,A61P 19/02,A61P 25/00,A61P 29/00,A61P 35/00,A61P 35/02,A61P 37/00,A61P 37/02,A61P 37/04,A61P 37/06,C07K 16/2893,C07K2317/24,C07K2317/34,C07K2317/52,C07K2317/565,C07K2317/64,C07K2317/732,C07K2317/734,C07K2317/76,C07K2317/94,C12N 15/63	[ "C12P 21/08", "A61K 39/395", "A61K 39/00" ]	95,611
48,740,996	1980-12-17	4,373,279	Y	A pyrrolobenzotriazepine or a pharmaceutically acceptable acid addition salt thereof is useful as a neuroleptic, anti-depressant or soporific.	en	Pyrrolobenzotriazepines	5243521_CH	6924534_CH,6212420_CH,6924533_CH	A61P 25/20,A61P 25/24,A61P 25/26,C07C 243/00,C07D 207/50,C07D 487/04	[ "A61P 25/24", "A61P 25/26", "A61P 25/20", "C07D 207/50", "A61K 31/00", "C07D 487/04" ]	37,687
50,925,114	1974-02-15	26,242,767	Y	1,1-DIPHENYL-2-HYDROXY-3-AMINOPROPANE DERIVATIVES ARE USEFUL FOR THEIR PSYCHOTROPIC ACTIVITY AND, IN PARTICULAR ARE USEFUL AS ANTIDEPRESSANTS.	en	Diphenylpropylamines	5286777_GB	8168126_GB	C07D 295/092	[ "C07C 227/08", "C07C 215/28", "C07C 67/00", "C07C 217/72", "C07C 213/00", "C07C 217/48", "C07C 219/22", "C07C 227/18", "C07C 227/16", "C07C 229/38", "C07D 295/084", "C07C 227/00" ]	40,937
491,368,367	2016-03-01	55,642,201	N	Die Erfindung betrifft spezifisch Amyloid-Beta bindende Peptide und deren Verwendung fUr die Therapie und Diagnose der Alzheimerschen Demenz.	en	Specific amyloid-beta binding peptides and the use of same for treating and diagnosing alzheimer's dementia	58585238_	60218305_,66411780_,59774838_,60822776_	A61K 38/00,A61K 38/10,A61P 25/28,C07K 7/08,C07K 7/64,C07K 14/4711,C07K 14/4713,G01N2333/4709,G01N2800/2821	[ "A61K 38/17", "A61P 25/28", "C07K 14/47" ]	115,972
16,650,404	1986-12-19	25,207,947	Y	-Thiobutyrolactone derivatives having short chain alpha - and/or gamma -alkyl or alkenyl substituents have useful anticonvulsant properties.	en	ANTICONVULSANT GAMMA-THIOBUTYROLACTONE DERIVATIVES	2462624_US	2590926_US,2590927_US,2590928_US	A61K 31/38,A61P 25/08,C07D 333/32	[ "A61K 31/381", "A61P 25/08", "A61K 31/38", "C07D 333/32" ]	17,525
421,525,401	2014-02-27	51,428,799	N	Provided herein, inter alia, are compounds useful in improving cognitive function, memory and learning in both healthy and diseased subjects.	en	IMPROVING COGNITIVE FUNCTION	6478238_US,5439802_US	49062021_US,9096832_US,48747152_KR	A61K 31/428	[ "A61K 31/426", "A01N 43/78", "A61K 31/425" ]	88,444
17,555,333	1986-08-11	9,322,162	Y	The compound of N-(1-cyclohexenylmethyl)2-pyrrolidinymethyl 8-ethylsulphonyl-1,5-benzodioxepanne-6-carboxamide is useful to treat psychoses.	en	Benzodioxepane, process for its preparation and its therapeutical use.	12729025_FR	25436765_,18742179_	A61P 25/20,C07D 207/09,C07D 321/10,C07D 405/12,C07D 407/12	[ "C07D 321/10", "C07D 207/09", "C07D 405/12", "A61P 25/20", "A61K 31/55", "A61K 31/40" ]	21,660
54,028,123	2001-06-28	27,499,010	N	A brain tumor is classified by type or grade includes the steps by quantifying the expression of an IL-13 receptor in a sample of the tumor.	en	Characterizing a brain tumor	37275364_	37275366_US	A61K 39/39558,A61K 47/51,A61K 47/642,A61K 47/6849,C07K 14/21,C07K 14/54,C07K 14/5406,C07K 14/5437,C07K 14/7155,C07K 16/2866,C07K2319/00,C12Q 1/6886,C12Q2600/156,G01N 33/57407,G01N 33/6869	[ "A61K 39/395", "A61K 38/20", "G01N 33/68", "A61K 38/00", "G01N 33/574", "C12Q 1/68", "C07K 16/28", "A61K 47/48", "A61K 51/08", "C07K 14/715", "C07K 14/21", "C07K 14/54" ]	47,895
363,623,426	2011-11-11	46,051,578	N	The invention provides compounds and a method for imaging aggregated a-synuclein, e.g., Lewy bodies or Lewy neurites, in a tissue or organ.	en	DEVELOPMENT AND SCREENING OF CONTRAST AGENTS FOR IN VIVO IMAGINING OF PARKINSON'S DISEASE	5545398_US,13073134_US	13073134_US	A61B 5/4082,A61K 49/0028,A61K 49/003,A61K 49/0052,A61K 51/0453,G01N 33/6896,G01N2800/2835	[ "A61B 5/055", "G01N 33/58", "A61K 49/06", "G01N 33/68" ]	73,722
48,141,076	2002-05-13	26,833,337	Y	The anticonvulsant derivative topiramate useful in treating dementia and/or behavioral and psychotic disturbances in dementia is disclosed.	en	Anticonvulsant derivatives useful in treating psychosis	5256834_US	6442747_US	A61K 31/18,A61K 31/35,A61K 31/505	[ "A61K 31/35", "A61K 31/18", "A61K 31/505" ]	36,732
555,812,032	2020-02-20	65,529,391	N	The invention relates to a single stranded antisense gapmer oligonucleotide comprising at least one dinucleoside of formula (I), wherein (A	en	Phosphonoacetate gapmer oligonucleotides	50427405_DK	81928147_,25582945_	A61K 31/7105,C12N 15/111,C12N 15/113,C12N2310/11,C12N2310/312,C12N2310/315,C12N2310/321,C12N2310/322,C12N2310/3231,C12N2310/3341,C12N2310/341,C12N2310/351	[ "C12N 15/113", "A61K 31/7125", "A61K 31/712", "C07H 21/02" ]	156,714
48,491,832	1980-09-12	22,686,246	Y	N-Oxacyclic-alkylpiperidyl-diazacompounds, e.g., those of the formula <IMAGE> and salts thereof are antidepressants and psychostimulants.	en	N-Oxacyclic-alkylpiperidines as psychostimulants	5232729_US	5403685_US	A61K 31/505,A61P 25/24,A61P 25/26,C07D 405/14	[ "A61K 31/505", "A61K 31/443", "A61K 31/445", "C07D 411/14", "C07D 405/14", "A61P 25/24", "A61P 25/26" ]	37,287
48,216,199	1980-05-27	26,726,018	Y	Piperazinone polypeptides which are useful as analgesics and psychotherapeutic agents as well as processes to produce them are described.	en	Piperazinone and piperazine polypeptides	5233995_US	5713484_US	C07C 51/08,C07C 51/60,C07D 241/04,C07D 241/08,C07D 243/08,C07D 403/06,C07K 14/70	[ "C07D 241/04", "C07K 14/70", "C07C 51/60", "C07D 403/06", "C07C 51/08", "C07D 241/08", "C07D 243/08" ]	36,854
52,848,254	1976-06-23	27,087,560	Y	Compounds of the class of 2-amino-3,4-dihydro-4-loweralkyl-5H-1,4-benzodiazepine-5-ones useful as CNS depressants and hypotensive agents.	en	2-Aminobenzodiazepine-5-ones	5317893_US	6263352_US,6263353_US	C07D 243/14	[ "C07D 243/14" ]	44,800
334,499,201	2010-06-04	44,082,666	N	Systems and methods of intracranial target localization using non-radiological direct surface imaging of one or more of the upper teeth.	en	STEREOTACTIC INTRACRANIAL TARGET LOCALIZATION GUIDANCE SYSTEMS AND METHODS	11775061_US,5219690_US	11775061_US	A61N 5/1049,A61N2005/1061,A61N2005/1097	[ "A61N 5/00" ]	67,999
321,214,839	2008-05-13	40,122,027	N	A method of treating neurodegeneration of substantia nigra pars compacta (SNpc) dopamine neurons and compositions therefor are provided.	en	Ghrelin Protects Substantia Nigra Dopamine Neurons	11493666_US,11493665_US	11493665_US,11493666_US	A61K 38/25,A61P 25/00	[ "A61P 25/00", "A61K 38/07", "A61K 38/16", "A61K 31/438", "A61K 31/55", "A61K 31/165", "C12N 5/0793", "A61K 31/4162", "A61K 31/4178" ]	63,413
52,610,251	2005-10-26	36,319,676	Y	NLO chromophores of the following general formula: wherein each R represents a spacer system or substituent moiety as disclosed herein.	en	Heterocyclical, substituted phenazinamine-type non-linear optic chromophore architectures	9414361_US,9414662_US	9414662_US,9414361_US	C07D 487/04,C07D 487/14,C09B 57/00,G02B 1/04,G02F 1/3612	[ "C07D 519/00", "C07D 241/46" ]	44,384
503,626,894	2017-05-02	56,528,099	Y	Provided herein is a humanized anti-BASIGIN antibody or antigen binding fragment thereof, which comprises heavy chain variable region(V	en	Humanized anti-BASIGIN antibodies and the use thereof	18310312_CN	34002928_,36992292_,37146280_,64965539_,58289633_,62198205_,58846059_,60910603_	A61K 9/0019,A61K 39/395,A61K2039/505,A61P 1/04,A61P 1/16,A61P 11/00,A61P 15/00,A61P 33/06,A61P 35/00,C07K 16/005,C07K 16/2803,C07K 16/32,C07K 16/42,C07K 16/4241,C07K2317/24,C07K2317/565,C07K2317/567,C07K2317/622,C07K2317/73,C07K2317/76,C07K2317/92,Y02A 50/30	[ "C07K 16/42", "A61P 35/00", "A61K 39/395", "A61P 33/06" ]	122,909
54,396,363	2004-10-27	22,353,506	Y	A time domain rule-based processor provides recognition of individual pulses in a pulse oximeter-derived photo-plethysmograph waveform.	en	Plethysmograph pulse recognition processor	5267949_US	5635371_US	A61B 5/02416,A61B 5/14551,A61B 5/7264	[ "A61B 5/0245", "G01N 21/27", "A61B 5/00", "G01N 21/35", "A61B 5/02", "A61B 5/024" ]	49,069
534,559,924	2020-01-10	71,516,706	N	Various embodiments of systems and methods for attention models with random features for multi-layered graph embeddings are disclosed.	en	SYSTEMS AND METHODS FOR A SUPRA-FUSION GRAPH ATTENTION MODEL FOR MULTI-LAYERED EMBEDDINGS AND DEEP LEARNING APPLICATIONS	5221254_US,74867059_US,48323488_US	74718075_US,51561769_US,11788544_US,69956373_US	G06F 16/9024,G06F 16/904,G06F 16/906,G06F 17/10,G06F 17/16,G06N 3/04,G06N 3/0454,G06N 3/084,G06N 3/105	[ "G06F 16/901", "G06N 3/08", "G06N 3/04", "G06F 17/16" ]	142,403
407,419,583	2013-06-12	46,640,923	N	The invention relates to biomarkers and a method of diagnosing or monitoring depression, anxiety disorder or other psychotic disorder.	en	BIOMARKERS FOR PSYCHOTIC DISORDERS, LIKE DEPRESSION AND ANXIETY DISORDER	8036119_GB,42678074_NL	29251517_GB,46580917_NL,46580916_NL,12500968_GB	G01N 33/573,G01N 33/68,G01N 33/6863,G01N 33/6866,G01N 33/6869,G01N2333/435,G01N2333/525,G01N2333/54,G01N2333/5403,G01N2333/5406,G01N2333/5409,G01N2333/5412,G01N2333/5418,G01N2333/5421,G01N2333/5428,G01N2333/55,G01N2333/555,G01N2333/57,G01N2333/96494,G01N2800/30,G01N2800/301	[ "G01N 33/68" ]	80,613
572,665,269	2021-11-17	81,587,045	N	Computerized systems, and method and computer readable media that store instructions for unsupervised signature based forensic search.	en	HISTORY BASED FACE SEARCHING	81809044_IL	83468169_IL,83464178_IL,83616336_IL,83467838_IL	G06F 16/535,G06F 16/583,G06V 40/172,G06V 40/179	[ "G06V 40/16", "G06F 16/535", "G06F 16/583" ]	165,964
53,380,550	1996-12-30	26,698,698	Y	Methods of treating and preventing drug-induced pruritus in patients by administration of a serotonin type 3 antagonist are provided.	en	Methods for treatment and prevention of drug-induced pruritus with serotonin type 3 receptor antagonists	9906194_US	9906195_US	A61K 31/4178,A61K 31/439,A61K 31/475	[ "A61K 31/475", "A61K 31/4178", "A61K 31/439" ]	45,931
548,952,433	2020-10-09	75,382,513	N	A number of illustrative variations may include a method or product for sensing driver intervention in an autonomous steering system.	en	OPTICS BASED DETECTION OF HANDS ON-OFF AND HAND GESTURE BASED FUNCTION SELECTION FOR HUMAN DRIVER	79580633_US,74870081_US	79602145_US	B60W 40/08,B60W 40/09,B60W 60/001,B60W 60/0055,B60W2420/42,B60W2510/202,B60W2540/223,B62D 1/02,B62D 1/046,B62D 1/06,B62D 1/16,B62D 1/286,B62D 15/02,B62D 15/025	[ "B62D 1/16", "B62D 1/06", "B60W 60/00", "B60W 40/08" ]	152,048
553,158,803	2021-03-04	76,546,613	N	The present disclosure generally relates to dynamic and adaptive systems and methods for rewarding and/or disincentivizing behaviors.	en	DYNAMIC AND ADAPTIVE SYSTEMS AND METHODS FOR REWARDING AND/OR DISINCENTIVIZING BEHAVIORS	79712868_US	56957150_US,79681821_US	A61B 5/0022,A61B 5/165,A61B 5/4833,A61B 5/4845,G06N 3/006,G06N 3/08,G06N 20/00,G06Q 10/0635,G06Q 50/18,G06Q 50/22,G06Q 50/265,G16H 10/60,G16H 20/70,G16H 50/30,H04L 67/12,H04L 67/535,H04W 4/029,H04W 4/38,Y02A 90/10	[ "G06N 20/00", "A61B 5/00", "A61B 5/16", "G16H 20/70", "G16H 10/60" ]	154,919
53,962,215	1997-06-23	21,807,338	Y	A method for treating obesity comprising administering a therapeutically effective amount of a compound of the formula: is disclosed.	en	Anticonvulsant derivatives useful in treating obesity	5243591_US	5923431_US	A61K 31/35,A61K 31/36,A61P 3/04,A61P 43/00	[ "A61K 31/35", "A61K 31/18", "A61P 3/04", "C07H 9/02", "A61K 31/70", "A61K 31/36", "H01R 12/14" ]	47,668
352,154,803	2012-03-15	46,027,547	Y	A Human Machine Interface includes a flight control system operable to communicate display data directly to a cockpit display system.	en	Integrated flight control and cockpit display system	49705186_US	5141355_US,5141354_US	G01C 23/00,G06F 3/1423,G09G2380/12	[ "G06F 3/14", "G01C 23/00" ]	72,676
488,864,619	2015-02-06	58,698,416	Y	Hexahydrofuropyrroles as PDE1 inhibitors and their usage for the treatment of neurodegenerative- and psychiatric disorders. Table: 1	en	HEXAHYDROFUROPYRROLES AS PDE1 INHIBITORS	8507643_DK	49041505_,33983145_,47642491_	A61K 31/407,A61K 31/4162,A61K 31/4375,A61P 25/00,A61P 25/14,A61P 25/16,A61P 25/18,A61P 25/24,A61P 25/28,A61P 25/30,A61P 25/32,A61P 25/36,C07B2200/13,C07D 403/04,C07D 405/04,C07D 491/048,C07D 519/00	[ "A61K 31/4375", "C07D 519/00", "A61K 31/4162", "C07D 403/04", "C07D 405/04", "A61K 31/407" ]	114,750
57,141,457	2008-10-16	40,564,077	Y	The present application describes a method of treating pain with a combination of a CB2 cannabinoid receptor agonist and rimonabast.	en	Method for reducing side effects of CB2 receptor agonist therapy using a combination of a selective CB2 receptor agonist and a selective CB1 receptor antagonist	5742182_US,5212606_US	5742182_US	A61K 31/427,A61K 31/44,A61K 31/454,A61P 3/04,A61P 3/10,A61P 9/00,A61P 11/00,A61P 25/00,A61P 25/04,A61P 25/28,A61P 29/00,A61P 35/00,A61P 37/00,A61P 43/00	[ "A61K 31/426", "A61P 25/28", "A61K 31/454", "A61K 31/44", "A61K 31/4453" ]	55,607
531,782,700	2019-03-27	66,005,837	N	Using this method, the raw sinogram data of dual tracers can be reconstructed into two volumetric individual images in a short time.	en	DYNAMIC DUAL-TRACER PET RECONSTRUCTION METHOD BASED ON HYBRID-LOSS 3D CONVOLUTIONAL NEURAL NETWORKS	10833475_CN	49927328_CN,72480591_CN	A61B 6/037,A61B 6/481,A61B 6/5205,A61M 5/007,G06N 3/04,G06N 3/0454,G06N 3/0481,G06N 3/08,G06T 11/003,G06T 11/005,G06T 11/006,G06T2210/41	[ "A61M 5/00", "G06N 3/04", "A61B 6/03", "G06T 11/00", "G06N 3/08" ]	140,688
339,621,583	2009-11-18	42,242,989	N	Methods are provided for designing a transition state inhibitor of orotate phosphoribosyltransferase (OPRT) and for inhibiting OPRT.	en	Transition state structure of orotate phosphoribosyl transferases and uses thereof	5626737_US	5626737_US	A61P 33/06,A61P 35/00,A61P 37/06,C12N 9/1077	[ "C12N 1/10", "A61P 33/06", "A61K 31/7034", "C12N 5/09", "C12N 9/99", "C12N 5/071", "A61P 37/06", "C07H 5/04", "A61P 35/00" ]	71,029
470,162,876	2016-06-15	57,015,708	N	The invention relates to a method for treating or preventing the development of emotion and/or mood disorders in a human individual.	en	Synthetic composition and method for modulating emotion and mood disorders	28101894_	53523907_CH,53513014_DK,53538742_SE	A61K 31/702,A61K 35/20	[ "A61K 35/20" ]	104,081
51,081,308	1974-04-22	25,600,725	Y	There are produced 6-aza-1,2-dihydro-3H-1,4-benzodiazepines of the formula: R1OR2 ¦¦ N-CH ANGLE ANGLE CH-R3 I Cl¦ C=N ¦ ¦R4 wherein:	en	Certain 2-oxy-5-phenyl-6-aza-7-chloro-1,2-dihydro-3H-1,4-benzodiazepines	12821644_	38633733_,38448472_	A61P 25/20,A61P 29/00,C07D 471/04,Y10S 514/916	[ "C07D 471/04", "A61P 29/00", "A61P 25/20", "A61K 31/55" ]	41,219
560,484,569	2020-03-20	65,991,742	N	Provided herein are methods for treating attention deficit hyperactivity disorder using KDM1A inhibitors, particularly vafidemstat.	en	METHODS OF TREATING ATTENTION DEFICIT HYPERACTIVITY DISORDER USING KDM1A INHIBITORS SUCH AS COMPOUND VAFIDEMSTAT	59708570_	84348619_,85636268_,83741522_	A61K 31/4245,A61P 25/00	[ "A61P 25/00", "A61K 31/4245" ]	159,711
56,999,009	2008-10-06	40,523,992	Y	The present invention relates to distributed computing system to acquire, process, and display OCT images at real-time frame rates.	en	REAL TIME SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY (SD-OCT) WITH DISTRIBUTED ACQUISITION AND PROCESSING	4176263_US	4285774_US,4285775_US,4285773_US	A61B 5/0066,A61B2090/378,G01B 9/02084,G01B 9/02089,G01B 9/02091,G01N 21/4795,G06T 1/20,G06T 11/003,G06T2207/10101,G06T2207/10132,G06T2207/20056,G06T2211/428	[ "G01B 11/02", "G01B 9/02", "A61B 5/00", "G01N 21/45" ]	55,386
440,097,918	2015-01-21	53,043,442	N	Methods and computing devices for measuring a range of motion of a musculoskeletal joint in a human or animal patient are provided.	en	METHODS AND COMPUTING DEVICES TO MEASURE MUSCULOSKELETAL MOVEMENT DEFICIENCIES	49974615_US	49945755_US,50061281_US,49979708_RS,49870683_AU	G06T 7/251,G06T 11/60,G06T2207/10016,G06T2207/20221,G06T2210/41,G16H 20/30,G16H 30/20,G16H 40/67	[ "G06T 7/20", "G06T 11/60", "G06F 19/00" ]	93,364
423,752,329	2013-02-11	51,870,132	Y	Methods for measuring B1 values in an MRI sample space, generating B1 maps and using B1 maps to correct B1 profiles are disclosed.	en	Methods of radio frequency magnetic field mapping	5486677_CA	48276824_CA,48293269_CA,48315125_CA,7213518_CA	G01R 33/246,G01R 33/5659	[ "G01V 3/00", "G01R 33/565" ]	90,084
16,604,798	1985-12-04	24,728,543	N	N-1-subs@@tuted-6-n-propyl-8 beta -methylthiomethylergoline@@e D-2 agonists which do not interact with alpha adrenergi@receptors.	en	Ergoline derivatives.	11700_US	2514350_US	A61P 9/12,A61P 13/02,A61P 15/00,A61P 25/00,A61P 25/24,A61P 25/26,C07D 457/02	[ "A61P 9/12", "A61K 31/48", "A61P 25/26", "A61P 15/00", "A61P 25/24", "C07D 457/02", "A61P 25/00", "A61P 13/02" ]	17,442
547,031,631	2020-09-08	74,850,979	N	Methods and systems for determining epistemic and aleatoric uncertainties using a dual neural network architecture are described.	en	DUAL NEURAL NETWORK ARCHITECTURE FOR DETERMINING EPISTEMIC AND ALEATORIC UNCERTAINTIES	5212098_US	53638273_US,79528797_CH,9817154_US	G06K 9/6259,G06K 9/6271,G06K 9/6278,G06N 3/0454,G06N 3/0472,G06N 3/08,G06N 3/082,G06N 3/084,G06N 5/04	[ "G06N 3/08", "G06N 5/04", "G06N 3/04", "G06K 9/62" ]	150,839
49,066,923	2003-01-27	7,638,473	Y	A neural network is used to obtain more robust performance in determining prosodic markers on the basis of linguistic categories.	en	Method and device for determining prosodic markers by neural autoassociators	5210496_DE	7180084_DE,7180083_DE	G10L 13/10,G10L 25/30	[ "G10L 25/30", "G10L 15/16", "G10L 13/10" ]	38,192
506,164,576	2018-07-13	64,998,690	Y	Real-time systems for monitoring base editing in living cells, including base editing by APOBEC-Cas9 fusions, is provided herein.	en	Real-time reporter systems for monitoring base editing	5502132_US	74710601_US,8319913_US,74818880_US	C07K 14/00,C07K 14/43504,C07K 14/43595,C07K 16/12,C07K 16/18,C07K2317/24,C07K2319/00,C07K2319/60,C12N 9/22,C12N 9/78,C12N 15/102,C12N 15/63,C12N 15/635,C12N 15/86,C12N2310/20,C12N2740/16043	[ "C07K 16/12", "C12N 15/10", "C07K 14/00", "C07K 14/435", "C07K 16/18", "C12N 15/00", "C12N 15/86", "C12N 9/22", "C12N 9/78", "C12N 15/63" ]	124,298
511,627,344	2016-09-04	66,174,827	Y	The exemplary embodiments present a system for easy and rapid communication, display, and comparison of object-directed feelings.	en	System for communication of object-directed feelings	69963388_US	69963388_US	G06F 16/24575,G06F 16/248,G06F 16/285,G06Q 50/01	[ "G06F 16/2457", "G06F 16/28", "G06F 16/248" ]	127,207
46,830,626	2002-02-14	23,022,675	Y	The present invention relates to a method of treating or preventing cerebral vasospasm that accompanies sub-arachnoid hemorrhage.	en	Therapy for cerebral vasospasm	5219375_US	5932470_US,5932468_US,5932469_US	A61K 31/00,A61K 38/005,A61K 38/482,A61K 38/4886,A61K2039/505,C07K 16/22,C07K2317/73,G01N 33/5088,G01N2333/78	[ "C07D 471/04", "C07D 471/22", "A61K 31/497", "C07D 487/04" ]	32,850
4,226,934	1985-06-11	25,822,036	Y	NAPHTHOXAZINES 3,4,4a,5,10,10a-hexahydro-2H-naphth¢2,3-b!-1,4-oxazines are useful as psychostimulating and antidepressant agents.	en	NAPHTHOXAZINES	12559364_DE	12559364_DE,16131203_DE	A61P 25/24,A61P 25/26,C07C 247/00,C07D 265/34,C07D 303/22	[ "A61K", "C07D 265/34", "C07C 247/14", "C07C 241/00", "C07C 217/74", "C07D", "C07D 303/22", "A61K 31/538", "A61K 31/535", "C07C 215/44", "C07D 303/14", "C07C 213/00", "A61P 25/26", "A61P 25/24", "C07D 265/36", "C07C 233/23", "C07C 67/00" ]	3,607
500,792,159	2018-03-30	63,672,361	N	The present invention relates to generally to a system for improving neuroplasticity and recovery for a patient in need thereof.	en	System of Improving Neuroplasticity and Recovery during Occupational, Physical, and Related Therapies	58074678_US	57975208_SE,58073283_US	A61B 5/18,A61B 5/4088,A63F 13/211,A63F 13/212,A63F 13/25,A63F 13/50,A63F 13/5255,A63F 13/80,G09B 5/062,G09B 19/00,G16H 20/30,G16H 20/70	[ "A63F 13/50", "G09B 19/00", "A61B 5/00", "G09B 5/06", "G16H 20/70", "A63F 13/80" ]	121,321
57,300,422	2008-11-09	40,626,218	N	Tetrahydroindolone and aryl piperazine derivatives for use in treating post-traumatic stress disorder and acute stress disorder.	en	TREATMENT OF POST-TRAUMATIC STRESS DISORDER WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS	40676537_US,40676539_US,40676540_US,40676538_US	40676540_US,40676538_US,40676539_US	A61K 31/497,A61P 25/00	[ "A61K 31/497" ]	55,957
196,167	2007-02-15	36,141,991	N	Compounds of the formula (I), inhibit D-amino acid oxidase and hence find use in treating degenerative and psychiatric diseases.	en	3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES	86853_GB,134090_US	288926_GB,288924_US,288925_GB,288927_GB	A61K 31/415,A61K 31/4155,A61P 25/28,C07D 231/06,C07D 401/04	[ "A61K 31/4155", "C07D 401/04", "A61K 31/415", "C07D 231/06" ]	1,054
512,773,613	2018-12-20	62,906,142	Y	Systems and methods for neutron detection using tensioned metastable fluid detectors, using a single atom spectroscopy approach.	en	Fast neuron spectroscopy with tensioned metastable fluid detectors	5210860_US	56915401_US,56954886_US	G01T 3/00,G01T 3/001,G01T 5/06	[ "G01T 5/06", "G01T 3/00" ]	127,808
266,850,843	2009-02-19	40,997,649	Y	A magnetic resonance imaging (MRI) method of obtaining MRI images of a patient and storing the images in physical storage media.	en	Arterial spin labeled, segmented, interleaved 3D GRASE MRI	6507281_US,11100304_US,11100303_US	11100304_US,11100303_US	G01R 33/4818,G01R 33/4822,G01R 33/4833,G01R 33/5618,G01R 33/56366,G01R 33/56536,G01R 33/56554,G01R 33/56563	[ "G01V 3/00", "G01R 33/54" ]	57,483
51,672,272	2005-06-16	20,289,905	Y	Selective phenyl substituted aminopyrazine inhibitors of GSK3 useful for the prevention and/or treatment of cognitive disorders.	en	Compounds having selective inhibiting effect at GSK3	5219843_SE,6045944_SE,6045942_SE,8707134_SE	8707134_SE,6045942_SE,6045944_SE	A61P 3/10,A61P 5/48,A61P 13/12,A61P 15/18,A61P 17/02,A61P 17/14,A61P 25/00,A61P 25/02,A61P 25/16,A61P 25/18,A61P 25/24,A61P 25/28,C07D 211/56,C07D 241/26,C07D 295/073,C07D 295/26,C07D 401/12,C07D 401/14,C07D 403/12,C07D 403/14	[ "A61P 25/00", "C07D 419/00", "A61K 31/497", "C07D 241/26", "C07D 295/073", "C07D 211/56", "C07D 405/00", "C07D 401/00", "C07D 295/26", "C07D 241/02", "C07D 403/00", "C07D 417/00", "C07D 401/12", "C07D 401/14", "C07D 409/00", "C07D 403/14", "C07D 403/02", "C07D 403/12", "C07D 413/00", "C07D 411/00", "A61K 31/50", "A61K 31/501", "A61P 15/18", "A61P 17/14", "A61P 5/48", "A61P 3/10" ]	42,561
48,619,985	1988-06-06	27,394,451	Y	Potent DBH Inhibitors having the formula: <IMAGE> wherein R is -CO2H or -CH2NHR1 can be used to inhibit DBH activity in mammals.	en	Dopamine- beta -hydroxylase inhibitors	5246023_US	6826979_US,5261317_US	C07D 501/20	[ "C07D 233/90", "C07D 233/64", "C07D 233/04" ]	37,491
53,024,497	1985-04-16	27,047,874	Y	Potent DBH Inhibitors having the formula: <IMAGE> wherein R is -CO2H or -CH2NHR1 can be used to inhibit DBH activity in mammals.	en	Dopamine beta -hydroxylase inhibitors	5246023_US	6826979_US,5246024_US,5261317_US	C07C 217/62,C07D 233/64,C07D 233/84,C07D 233/90	[ "C07D 233/90", "C07D 233/84", "C07D 233/54", "C07C 217/62" ]	45,158
51,720,081	2006-10-10	38,534,522	Y	The invention relates, in part, to methods of administering electrical or magnetic brain stimulation to increase learning rate.	en	Methods of increasing learning rate	5219722_US,8747666_US,8747667_US	8747666_US,8747667_US	A61N 1/36025,A61N 1/36082,A61N 2/004	[ "A61N 1/00" ]	42,646
51,707,039	1990-06-25	27,397,911	Y	Radioiodine 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine derivatives and their use as brain imaging agents.	en	Radioiodine benzodiazepines as brain imaging agents	5803590_US	8736566_AT,5743674_CH	A61K 51/047,A61K2123/00	[ "A61K 51/04" ]	42,617
315,436,943	2009-11-18	39,225,245	Y	A method of reducing the incidences of bupropion induced seizures by coadministration of a bromide salt with a bupropion salt.	en	Bupropion hydrobromide and therapeutic applications	10154985_CA,10154984_IE,11016441_BM	10154984_IE,10154985_CA	A61K 9/2846,A61K 9/2866,A61K 9/2886,A61K 31/135,A61K 33/00,A61P 3/04,A61P 25/08,A61P 25/24,A61P 25/34	[ "A61K 9/28", "A61K 9/24", "A61K 31/135", "A61K 31/137", "A61P 25/08" ]	61,547
49,546,266	1981-10-26	6,115,503	Y	The decapeptide of the formula H-Ser-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-OH and the use thereof as hapten, tracer or antibody.	en	Decapeptide	7514144_DE	5482617_AT,7514140_DE,7514145_DE,6454011_DE	C07K 14/555,C07K 16/249,G01N 33/531,G01N 33/58,Y10S 530/806,Y10S 930/142	[ "C07K 14/52", "G01N 33/58", "C07K 7/06", "G01N 33/531", "C07K 14/555", "C07K 19/00", "C07K 16/24" ]	38,952
54,366,199	2004-10-15	34,681,396	Y	A method and apparatus for ascertaining the cerebral state of a patient using generalized spectral entropy of the EEG signal.	en	Method and apparatus for determining the cerebral state of a patient using generalized spectral entropy of the EEG signal	5258508_FI	6661311_FI	A61B 5/374,A61B 5/7203,A61B 5/7257	[ "A61B 5/374" ]	48,937
481,732,729	2017-01-26	45,464,626	Y	The invention relates to a method of differentially diagnosing schizophrenia, bipolar disorder and major depressive disorder.	en	Quantifying biomarkers for diagnosing and treating schizophrenia, bipolar disorder or major depression	5625935_GB	8843796_GB,11806623_GB	G01N 33/50,G01N 33/52,G01N 33/5308,G01N 33/573,G01N 33/6893,G01N 33/6896,G01N2333/96494,G01N2800/28,G01N2800/2814,G01N2800/30,G01N2800/302,G01N2800/304	[ "G01N 33/573", "G01N 33/53", "G01N 33/52", "G01N 33/50" ]	110,442
17,451,867	1999-10-29	22,312,313	Y	A combination of a 5HT1B/1D agonist and a COX-2 selective inhibitor is useful in the treatment and or prevention of migraine.	en	COMBINATIONS OF A 5HT1B/1D AGONIST AND A SELECTIVE COX-2 INHIBITOR FOR THE TREATMENT OF MIGRAINE	34620_US	4063230_US,4063232_US,4063228_US,4063229_US,4063231_US,4063233_US	A61K 31/40,A61K 31/415,A61K 31/42,A61K 31/54,A61K 45/06,A61P 25/06	[ "A61K 31/42", "A61K 31/4196", "A61K 31/404", "A61K 31/421", "A61K 45/06", "A61P 25/06", "A61K 31/422", "A61K 31/5415", "A61K 31/454" ]	21,013
50,787,462	1995-04-17	26,299,069	Y	4-(Fluorobenzoylamino)-3,4-dihydro-benzopyran derivatives are disclosed to possess anxiolytic and anti-convulsant activities.	en	Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity	5307715_GB	8079751_GB,8079753_GB,8079752_GB	C07D 215/48,C07D 311/68,C07D 311/70,C07D 311/72,C07D 491/04	[ "C07D 215/48", "C07D 311/68", "C07D 311/70", "C07D 491/04", "C07D 311/72" ]	40,686
53,291,063	1977-01-19	24,730,617	Y	2-Piperidinoalkyl-1,4-benzodioxans, e.g. those of the formula <IMAGE> and acid addition salts thereof are neuroleptic agents.	en	Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans	5232729_US	5403685_US	C07D 409/14	[ "C07D 409/14" ]	45,705
54,570,421	2005-10-19	36,203,725	N	Discrete and diffuse defects in a surface are detected. Discrete defects that may compromise the performance may be repaired.	en	BIOMOLECULAR RECOGNITION OF CRYSTAL DEFECTS	39764209_US,33315314_US,5298000_US	39764209_US,33315314_US	A61L 33/12,B05D 1/02,B05D 3/00,B05D 5/005,B32B 43/00,C07K 7/06,C23C 18/1608,C23C 18/1692,C23C 18/1831,C23C 18/1834,C23C 18/1879,C23C 18/1882,G01N 33/6845,H01L 21/28	[ "B05D 3/00", "B05D 1/02", "A61L 33/12", "B32B 43/00" ]	50,617
501,683,598	2018-04-11	63,792,506	N	The present invention uses an autoantibody to a small unmyelinated dorsal root ganglion neuron as a neuropathic pain marker.	en	NEUROPATHIC PAIN MARKER AND USE THEREOF	64085581_JP	64105875_JP,66929767_JP,69111422_JP,64058432_JP,64136173_JP,69114894_JP	G01N 33/53	[ "G01N 33/53" ]	121,715
51,481,304	2005-10-21	29,584,413	Y	Methods and kits for treating inflammatory conditions are described that include modulating kallikrein 6 protease activity.	en	Method of treating multiple sclerosis with anti-K6 antibody	5350306_US,8546311_US,5795316_US,8546312_US,8546310_US,5219690_US	8546311_US,8546310_US,8546312_US,5350306_US	A61K 39/3955,A61K2039/57,A61P 11/06,A61P 37/00,C07K 16/40,C07K2317/76,C12Q 1/37,C12Q 1/6883,C12Q2600/158,G01N 33/564,G01N2333/96455,G01N2800/102,G01N2800/104,G01N2800/24,G01N2800/285	[ "G01N 33/564", "G01N 33/53", "C12Q 1/37", "C12N 9/64", "C07K 16/40", "A61K 48/00", "C12Q 1/68", "C07H 21/02", "A61K 39/395" ]	42,174
49,354,534	1972-09-18	26,668,431	Y	The compounds are 1,4-diaminobut-2-yne derivatives of pyrrolidinone which are useful as central nervous system depressants.	en	CYCLIC AMIDES OF 1,4-DIAMINOBUT-2-YNE	26137214_	38402502_,38468140_	C07D 207/26,C07D 207/27	[ "C07D 207/27", "C07D 207/26" ]	38,619
48,689,267	1980-11-28	26,754,084	Y	Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as anti-depressants, tranquilizers, analgesics and anticonvulsants.	en	3''-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1''-(3''H)-isobenzofuran]	6882847_US	5922592_DE,5307138_US	C07D 263/14,C07D 307/94,C07D 493/10	[ "C07D 263/14", "C07D 493/10", "C07D 307/94" ]	37,599
50,456,184	2006-05-12	37,525,059	Y	Devices and methods to treat atrial fibrillation via inhibition of nerves which innervate the pulmonary vein are provided.	en	Neurotoxic agents and devices to treat atrial fibrillation	5224734_US,5329999_US	5329999_US	A61N 1/057,A61N 1/0575,A61N 1/3625	[ "A61M 29/00", "A61M 31/00", "A61N 1/00" ]	40,052
446,052,309	2012-06-08	44,189,204	N	Automated behavioral methods and systems for treating Insomnia that use passive means for determining wake I sleep states.	en	'AUTOMATED TREATMENT SYSTEM FOR SLEEP'	52275672_US	51816898_US,52032948_US,52229570_US	A61B 5/4809,A61M 21/00,A61M2021/0016,A61M2021/0022,A61M2021/0027,A61M2021/0072,A61M2230/10,A61M2230/18,A61M2230/42,A61M2230/60,A61M2230/63,A61M2230/65	[ "A47J" ]	97,177
48,513,129	1971-10-14	4,414,035	Y	A method for preparing N-benzyloxycarbonyl-dopa derivatives useful as hypotensive, anti-pyretic and anti-Parkinson agents.	en	N-BENZYLOXYCARBONYL-DOPA DERIVATIVES	37221778_	38243830_,38243829_,38243831_,34931839_	C07F 5/04,Y10S 514/916	[ "C07F 5/04" ]	37,311
404,768,022	2011-07-22	45,530,007	N	Existing pain-relief devices have the problem that the use thereof requires specialized knowledge of Eastern acupuncture,	en	Pain-relief device	6428373_JP	44399623_,13871493_	A61H 39/06,A61H2201/0153,A61H2201/10,A61H2201/50,A61H2201/5028,A61H2201/5043,A61H2201/5058,A61N 5/0619,A61N 5/067,A61N2005/0644,A61N2005/0659	[ "A61N 5/06", "A61H 39/00" ]	78,699
4,053,702	1977-03-04	24,673,972	Y	Nonionic triiodobenzoyl amino acyl derivatives of polyhydroxy amines which are useful as nonionic X-ray contrast agents.	en	N-TRIIODO-BENZOYLAMINOACYL POLYHYDROXIC AMINES	7760213_	15963531_	C07C 233/12	[ "C07C 237/46", "C07C 311/00", "C07C 67/00", "C07C 303/40", "C07C 231/00", "A61K 31/165", "C07C 301/00", "C07C 233/12", "A61K 49/04", "C07C 231/02" ]	3,306

523,340,322

2019-05-22

66,867,788

Y

Described are methods of modulating the activation of the TRPV1 ion channel by administering at least one cannabinoid and/or terpene compound.

en

TRPV1 activation-modulating complex mixtures of cannabinoids and/or terpenes

72250102_CA

56967828_US,11528936_US

A61K 31/01,A61K 31/015,A61K 31/045,A61K 31/05,A61K 31/352

[ "A61K 31/05", "A61K 31/352", "A61K 31/01" ]

134,830

437,152,693

2006-11-09

52,473,077

Y

Improvements in magnetic resonance imaging methods to obtain three-dimensional models and diagnoses of Thoracic Outlet Syndrome are described.

en

Method to evaluate patients for thoracic outlet syndrome

50026655_US,50010614_US

50026655_US

A61B 5/004,A61B 5/02007,A61B 5/055,A61B 5/7282,A61B2576/00,G16H 30/40

[ "A61B 5/05" ]

91,942

444,302,596

2010-05-13

43,085,579

N

Disclosed is an antibody which binds to CD53 comprising the CDRs GFTFSDAWMD, EIRNKAKNHATYYAESVKG, TTLDS, KSSQSLLDSDGKTYLN, LVSALDS, WQGTHFPWT.

en

Anti-human cd52 immunoglobulins

5221479_

43642437_,47647322_,38533831_,37226327_

A61K 39/395,A61K2039/505,A61P 9/00,A61P 19/02,A61P 25/00,A61P 29/00,A61P 35/00,A61P 35/02,A61P 37/00,A61P 37/02,A61P 37/04,A61P 37/06,C07K 16/2893,C07K2317/24,C07K2317/34,C07K2317/52,C07K2317/565,C07K2317/64,C07K2317/732,C07K2317/734,C07K2317/76,C07K2317/94,C12N 15/63

[ "C12P 21/08", "A61K 39/395", "A61K 39/00" ]

95,611

48,740,996

1980-12-17

4,373,279

Y

A pyrrolobenzotriazepine or a pharmaceutically acceptable acid addition salt thereof is useful as a neuroleptic, anti-depressant or soporific.

en

Pyrrolobenzotriazepines

5243521_CH

6924534_CH,6212420_CH,6924533_CH

A61P 25/20,A61P 25/24,A61P 25/26,C07C 243/00,C07D 207/50,C07D 487/04

[ "A61P 25/24", "A61P 25/26", "A61P 25/20", "C07D 207/50", "A61K 31/00", "C07D 487/04" ]

37,687

50,925,114

1974-02-15

26,242,767

Y

1,1-DIPHENYL-2-HYDROXY-3-AMINOPROPANE DERIVATIVES ARE USEFUL FOR THEIR PSYCHOTROPIC ACTIVITY AND, IN PARTICULAR ARE USEFUL AS ANTIDEPRESSANTS.

en

Diphenylpropylamines

5286777_GB

8168126_GB

C07D 295/092

[ "C07C 227/08", "C07C 215/28", "C07C 67/00", "C07C 217/72", "C07C 213/00", "C07C 217/48", "C07C 219/22", "C07C 227/18", "C07C 227/16", "C07C 229/38", "C07D 295/084", "C07C 227/00" ]

40,937

491,368,367

2016-03-01

55,642,201

N

Die Erfindung betrifft spezifisch Amyloid-Beta bindende Peptide und deren Verwendung fUr die Therapie und Diagnose der Alzheimerschen Demenz.

en

Specific amyloid-beta binding peptides and the use of same for treating and diagnosing alzheimer's dementia

58585238_

60218305_,66411780_,59774838_,60822776_

A61K 38/00,A61K 38/10,A61P 25/28,C07K 7/08,C07K 7/64,C07K 14/4711,C07K 14/4713,G01N2333/4709,G01N2800/2821

[ "A61K 38/17", "A61P 25/28", "C07K 14/47" ]

115,972

16,650,404

1986-12-19

25,207,947

Y

-Thiobutyrolactone derivatives having short chain alpha - and/or gamma -alkyl or alkenyl substituents have useful anticonvulsant properties.

en

ANTICONVULSANT GAMMA-THIOBUTYROLACTONE DERIVATIVES

2462624_US

2590926_US,2590927_US,2590928_US

A61K 31/38,A61P 25/08,C07D 333/32

[ "A61K 31/381", "A61P 25/08", "A61K 31/38", "C07D 333/32" ]

17,525

421,525,401

2014-02-27

51,428,799

N

Provided herein, inter alia, are compounds useful in improving cognitive function, memory and learning in both healthy and diseased subjects.

en

IMPROVING COGNITIVE FUNCTION

6478238_US,5439802_US

49062021_US,9096832_US,48747152_KR

A61K 31/428

[ "A61K 31/426", "A01N 43/78", "A61K 31/425" ]

88,444

17,555,333

1986-08-11

9,322,162

Y

The compound of N-(1-cyclohexenylmethyl)2-pyrrolidinymethyl 8-ethylsulphonyl-1,5-benzodioxepanne-6-carboxamide is useful to treat psychoses.

en

Benzodioxepane, process for its preparation and its therapeutical use.

12729025_FR

25436765_,18742179_

A61P 25/20,C07D 207/09,C07D 321/10,C07D 405/12,C07D 407/12

[ "C07D 321/10", "C07D 207/09", "C07D 405/12", "A61P 25/20", "A61K 31/55", "A61K 31/40" ]

21,660

54,028,123

2001-06-28

27,499,010

N

A brain tumor is classified by type or grade includes the steps by quantifying the expression of an IL-13 receptor in a sample of the tumor.

en

Characterizing a brain tumor

37275364_

37275366_US

A61K 39/39558,A61K 47/51,A61K 47/642,A61K 47/6849,C07K 14/21,C07K 14/54,C07K 14/5406,C07K 14/5437,C07K 14/7155,C07K 16/2866,C07K2319/00,C12Q 1/6886,C12Q2600/156,G01N 33/57407,G01N 33/6869

[ "A61K 39/395", "A61K 38/20", "G01N 33/68", "A61K 38/00", "G01N 33/574", "C12Q 1/68", "C07K 16/28", "A61K 47/48", "A61K 51/08", "C07K 14/715", "C07K 14/21", "C07K 14/54" ]

47,895

363,623,426

2011-11-11

46,051,578

N

The invention provides compounds and a method for imaging aggregated a-synuclein, e.g., Lewy bodies or Lewy neurites, in a tissue or organ.

en

DEVELOPMENT AND SCREENING OF CONTRAST AGENTS FOR IN VIVO IMAGINING OF PARKINSON'S DISEASE

5545398_US,13073134_US

13073134_US

A61B 5/4082,A61K 49/0028,A61K 49/003,A61K 49/0052,A61K 51/0453,G01N 33/6896,G01N2800/2835

[ "A61B 5/055", "G01N 33/58", "A61K 49/06", "G01N 33/68" ]

73,722

48,141,076

2002-05-13

26,833,337

Y

The anticonvulsant derivative topiramate useful in treating dementia and/or behavioral and psychotic disturbances in dementia is disclosed.

en

Anticonvulsant derivatives useful in treating psychosis

5256834_US

6442747_US

A61K 31/18,A61K 31/35,A61K 31/505

[ "A61K 31/35", "A61K 31/18", "A61K 31/505" ]

36,732

555,812,032

2020-02-20

65,529,391

N

The invention relates to a single stranded antisense gapmer oligonucleotide comprising at least one dinucleoside of formula (I), wherein (A

en

Phosphonoacetate gapmer oligonucleotides

50427405_DK

81928147_,25582945_

A61K 31/7105,C12N 15/111,C12N 15/113,C12N2310/11,C12N2310/312,C12N2310/315,C12N2310/321,C12N2310/322,C12N2310/3231,C12N2310/3341,C12N2310/341,C12N2310/351

[ "C12N 15/113", "A61K 31/7125", "A61K 31/712", "C07H 21/02" ]

156,714

48,491,832

1980-09-12

22,686,246

Y

N-Oxacyclic-alkylpiperidyl-diazacompounds, e.g., those of the formula <IMAGE> and salts thereof are antidepressants and psychostimulants.

en

N-Oxacyclic-alkylpiperidines as psychostimulants

5232729_US

5403685_US

A61K 31/505,A61P 25/24,A61P 25/26,C07D 405/14

[ "A61K 31/505", "A61K 31/443", "A61K 31/445", "C07D 411/14", "C07D 405/14", "A61P 25/24", "A61P 25/26" ]

37,287

48,216,199

1980-05-27

26,726,018

Y

Piperazinone polypeptides which are useful as analgesics and psychotherapeutic agents as well as processes to produce them are described.

en

Piperazinone and piperazine polypeptides

5233995_US

5713484_US

C07C 51/08,C07C 51/60,C07D 241/04,C07D 241/08,C07D 243/08,C07D 403/06,C07K 14/70

[ "C07D 241/04", "C07K 14/70", "C07C 51/60", "C07D 403/06", "C07C 51/08", "C07D 241/08", "C07D 243/08" ]

36,854

52,848,254

1976-06-23

27,087,560

Y

Compounds of the class of 2-amino-3,4-dihydro-4-loweralkyl-5H-1,4-benzodiazepine-5-ones useful as CNS depressants and hypotensive agents.

en

2-Aminobenzodiazepine-5-ones

5317893_US

6263352_US,6263353_US

C07D 243/14

[ "C07D 243/14" ]

44,800

334,499,201

2010-06-04

44,082,666

N

Systems and methods of intracranial target localization using non-radiological direct surface imaging of one or more of the upper teeth.

en

STEREOTACTIC INTRACRANIAL TARGET LOCALIZATION GUIDANCE SYSTEMS AND METHODS

11775061_US,5219690_US

11775061_US

A61N 5/1049,A61N2005/1061,A61N2005/1097

[ "A61N 5/00" ]

67,999

321,214,839

2008-05-13

40,122,027

N

A method of treating neurodegeneration of substantia nigra pars compacta (SNpc) dopamine neurons and compositions therefor are provided.

en

Ghrelin Protects Substantia Nigra Dopamine Neurons

11493666_US,11493665_US

11493665_US,11493666_US

A61K 38/25,A61P 25/00

[ "A61P 25/00", "A61K 38/07", "A61K 38/16", "A61K 31/438", "A61K 31/55", "A61K 31/165", "C12N 5/0793", "A61K 31/4162", "A61K 31/4178" ]

63,413

52,610,251

2005-10-26

36,319,676

Y

NLO chromophores of the following general formula: wherein each R represents a spacer system or substituent moiety as disclosed herein.

en

Heterocyclical, substituted phenazinamine-type non-linear optic chromophore architectures

9414361_US,9414662_US

9414662_US,9414361_US

C07D 487/04,C07D 487/14,C09B 57/00,G02B 1/04,G02F 1/3612

[ "C07D 519/00", "C07D 241/46" ]

44,384

503,626,894

2017-05-02

56,528,099

Y

Provided herein is a humanized anti-BASIGIN antibody or antigen binding fragment thereof, which comprises heavy chain variable region(V

en

Humanized anti-BASIGIN antibodies and the use thereof

18310312_CN

34002928_,36992292_,37146280_,64965539_,58289633_,62198205_,58846059_,60910603_

A61K 9/0019,A61K 39/395,A61K2039/505,A61P 1/04,A61P 1/16,A61P 11/00,A61P 15/00,A61P 33/06,A61P 35/00,C07K 16/005,C07K 16/2803,C07K 16/32,C07K 16/42,C07K 16/4241,C07K2317/24,C07K2317/565,C07K2317/567,C07K2317/622,C07K2317/73,C07K2317/76,C07K2317/92,Y02A 50/30

[ "C07K 16/42", "A61P 35/00", "A61K 39/395", "A61P 33/06" ]

122,909

54,396,363

2004-10-27

22,353,506

Y

A time domain rule-based processor provides recognition of individual pulses in a pulse oximeter-derived photo-plethysmograph waveform.

en

Plethysmograph pulse recognition processor

5267949_US

5635371_US

A61B 5/02416,A61B 5/14551,A61B 5/7264

[ "A61B 5/0245", "G01N 21/27", "A61B 5/00", "G01N 21/35", "A61B 5/02", "A61B 5/024" ]

49,069

534,559,924

2020-01-10

71,516,706

N

Various embodiments of systems and methods for attention models with random features for multi-layered graph embeddings are disclosed.

en

SYSTEMS AND METHODS FOR A SUPRA-FUSION GRAPH ATTENTION MODEL FOR MULTI-LAYERED EMBEDDINGS AND DEEP LEARNING APPLICATIONS

5221254_US,74867059_US,48323488_US

74718075_US,51561769_US,11788544_US,69956373_US

G06F 16/9024,G06F 16/904,G06F 16/906,G06F 17/10,G06F 17/16,G06N 3/04,G06N 3/0454,G06N 3/084,G06N 3/105

[ "G06F 16/901", "G06N 3/08", "G06N 3/04", "G06F 17/16" ]

142,403

407,419,583

2013-06-12

46,640,923

N

The invention relates to biomarkers and a method of diagnosing or monitoring depression, anxiety disorder or other psychotic disorder.

en

BIOMARKERS FOR PSYCHOTIC DISORDERS, LIKE DEPRESSION AND ANXIETY DISORDER

8036119_GB,42678074_NL

29251517_GB,46580917_NL,46580916_NL,12500968_GB

G01N 33/573,G01N 33/68,G01N 33/6863,G01N 33/6866,G01N 33/6869,G01N2333/435,G01N2333/525,G01N2333/54,G01N2333/5403,G01N2333/5406,G01N2333/5409,G01N2333/5412,G01N2333/5418,G01N2333/5421,G01N2333/5428,G01N2333/55,G01N2333/555,G01N2333/57,G01N2333/96494,G01N2800/30,G01N2800/301

[ "G01N 33/68" ]

80,613

572,665,269

2021-11-17

81,587,045

N

Computerized systems, and method and computer readable media that store instructions for unsupervised signature based forensic search.

en

HISTORY BASED FACE SEARCHING

81809044_IL

83468169_IL,83464178_IL,83616336_IL,83467838_IL

G06F 16/535,G06F 16/583,G06V 40/172,G06V 40/179

[ "G06V 40/16", "G06F 16/535", "G06F 16/583" ]

165,964

53,380,550

1996-12-30

26,698,698

Y

Methods of treating and preventing drug-induced pruritus in patients by administration of a serotonin type 3 antagonist are provided.

en

Methods for treatment and prevention of drug-induced pruritus with serotonin type 3 receptor antagonists

9906194_US

9906195_US

A61K 31/4178,A61K 31/439,A61K 31/475

[ "A61K 31/475", "A61K 31/4178", "A61K 31/439" ]

45,931

548,952,433

2020-10-09

75,382,513

N

A number of illustrative variations may include a method or product for sensing driver intervention in an autonomous steering system.

en

OPTICS BASED DETECTION OF HANDS ON-OFF AND HAND GESTURE BASED FUNCTION SELECTION FOR HUMAN DRIVER

79580633_US,74870081_US

79602145_US

B60W 40/08,B60W 40/09,B60W 60/001,B60W 60/0055,B60W2420/42,B60W2510/202,B60W2540/223,B62D 1/02,B62D 1/046,B62D 1/06,B62D 1/16,B62D 1/286,B62D 15/02,B62D 15/025

[ "B62D 1/16", "B62D 1/06", "B60W 60/00", "B60W 40/08" ]

152,048

553,158,803

2021-03-04

76,546,613

N

The present disclosure generally relates to dynamic and adaptive systems and methods for rewarding and/or disincentivizing behaviors.

en

DYNAMIC AND ADAPTIVE SYSTEMS AND METHODS FOR REWARDING AND/OR DISINCENTIVIZING BEHAVIORS

79712868_US

56957150_US,79681821_US

A61B 5/0022,A61B 5/165,A61B 5/4833,A61B 5/4845,G06N 3/006,G06N 3/08,G06N 20/00,G06Q 10/0635,G06Q 50/18,G06Q 50/22,G06Q 50/265,G16H 10/60,G16H 20/70,G16H 50/30,H04L 67/12,H04L 67/535,H04W 4/029,H04W 4/38,Y02A 90/10

[ "G06N 20/00", "A61B 5/00", "A61B 5/16", "G16H 20/70", "G16H 10/60" ]

154,919

53,962,215

1997-06-23

21,807,338

Y

A method for treating obesity comprising administering a therapeutically effective amount of a compound of the formula: is disclosed.

en

Anticonvulsant derivatives useful in treating obesity

5243591_US

5923431_US

A61K 31/35,A61K 31/36,A61P 3/04,A61P 43/00

[ "A61K 31/35", "A61K 31/18", "A61P 3/04", "C07H 9/02", "A61K 31/70", "A61K 31/36", "H01R 12/14" ]

47,668

352,154,803

2012-03-15

46,027,547

Y

A Human Machine Interface includes a flight control system operable to communicate display data directly to a cockpit display system.

en

Integrated flight control and cockpit display system

49705186_US

5141355_US,5141354_US

G01C 23/00,G06F 3/1423,G09G2380/12

[ "G06F 3/14", "G01C 23/00" ]

72,676

488,864,619

2015-02-06

58,698,416

Y

Hexahydrofuropyrroles as PDE1 inhibitors and their usage for the treatment of neurodegenerative- and psychiatric disorders. Table: 1

en

HEXAHYDROFUROPYRROLES AS PDE1 INHIBITORS

8507643_DK

49041505_,33983145_,47642491_

A61K 31/407,A61K 31/4162,A61K 31/4375,A61P 25/00,A61P 25/14,A61P 25/16,A61P 25/18,A61P 25/24,A61P 25/28,A61P 25/30,A61P 25/32,A61P 25/36,C07B2200/13,C07D 403/04,C07D 405/04,C07D 491/048,C07D 519/00

[ "A61K 31/4375", "C07D 519/00", "A61K 31/4162", "C07D 403/04", "C07D 405/04", "A61K 31/407" ]

114,750

57,141,457

2008-10-16

40,564,077

Y

The present application describes a method of treating pain with a combination of a CB2 cannabinoid receptor agonist and rimonabast.

en

Method for reducing side effects of CB2 receptor agonist therapy using a combination of a selective CB2 receptor agonist and a selective CB1 receptor antagonist

5742182_US,5212606_US

5742182_US

A61K 31/427,A61K 31/44,A61K 31/454,A61P 3/04,A61P 3/10,A61P 9/00,A61P 11/00,A61P 25/00,A61P 25/04,A61P 25/28,A61P 29/00,A61P 35/00,A61P 37/00,A61P 43/00

[ "A61K 31/426", "A61P 25/28", "A61K 31/454", "A61K 31/44", "A61K 31/4453" ]

55,607

531,782,700

2019-03-27

66,005,837

N

Using this method, the raw sinogram data of dual tracers can be reconstructed into two volumetric individual images in a short time.

en

DYNAMIC DUAL-TRACER PET RECONSTRUCTION METHOD BASED ON HYBRID-LOSS 3D CONVOLUTIONAL NEURAL NETWORKS

10833475_CN

49927328_CN,72480591_CN

A61B 6/037,A61B 6/481,A61B 6/5205,A61M 5/007,G06N 3/04,G06N 3/0454,G06N 3/0481,G06N 3/08,G06T 11/003,G06T 11/005,G06T 11/006,G06T2210/41

[ "A61M 5/00", "G06N 3/04", "A61B 6/03", "G06T 11/00", "G06N 3/08" ]

140,688

339,621,583

2009-11-18

42,242,989

N

Methods are provided for designing a transition state inhibitor of orotate phosphoribosyltransferase (OPRT) and for inhibiting OPRT.

en

Transition state structure of orotate phosphoribosyl transferases and uses thereof

5626737_US

A61P 33/06,A61P 35/00,A61P 37/06,C12N 9/1077

[ "C12N 1/10", "A61P 33/06", "A61K 31/7034", "C12N 5/09", "C12N 9/99", "C12N 5/071", "A61P 37/06", "C07H 5/04", "A61P 35/00" ]

71,029

470,162,876

2016-06-15

57,015,708

N

The invention relates to a method for treating or preventing the development of emotion and/or mood disorders in a human individual.

en

Synthetic composition and method for modulating emotion and mood disorders

28101894_

53523907_CH,53513014_DK,53538742_SE

A61K 31/702,A61K 35/20

[ "A61K 35/20" ]

104,081

51,081,308

1974-04-22

25,600,725

Y

There are produced 6-aza-1,2-dihydro-3H-1,4-benzodiazepines of the formula: R1OR2 ¦¦ N-CH ANGLE ANGLE CH-R3 I Cl¦ C=N ¦ ¦R4 wherein:

en

Certain 2-oxy-5-phenyl-6-aza-7-chloro-1,2-dihydro-3H-1,4-benzodiazepines

12821644_

38633733_,38448472_

A61P 25/20,A61P 29/00,C07D 471/04,Y10S 514/916

[ "C07D 471/04", "A61P 29/00", "A61P 25/20", "A61K 31/55" ]

41,219

560,484,569

2020-03-20

65,991,742

N

Provided herein are methods for treating attention deficit hyperactivity disorder using KDM1A inhibitors, particularly vafidemstat.

en

METHODS OF TREATING ATTENTION DEFICIT HYPERACTIVITY DISORDER USING KDM1A INHIBITORS SUCH AS COMPOUND VAFIDEMSTAT

59708570_

84348619_,85636268_,83741522_

A61K 31/4245,A61P 25/00

[ "A61P 25/00", "A61K 31/4245" ]

159,711

56,999,009

2008-10-06

40,523,992

Y

The present invention relates to distributed computing system to acquire, process, and display OCT images at real-time frame rates.

en

REAL TIME SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY (SD-OCT) WITH DISTRIBUTED ACQUISITION AND PROCESSING

4176263_US

4285774_US,4285775_US,4285773_US

A61B 5/0066,A61B2090/378,G01B 9/02084,G01B 9/02089,G01B 9/02091,G01N 21/4795,G06T 1/20,G06T 11/003,G06T2207/10101,G06T2207/10132,G06T2207/20056,G06T2211/428

[ "G01B 11/02", "G01B 9/02", "A61B 5/00", "G01N 21/45" ]

55,386

440,097,918

2015-01-21

53,043,442

N

Methods and computing devices for measuring a range of motion of a musculoskeletal joint in a human or animal patient are provided.

en

METHODS AND COMPUTING DEVICES TO MEASURE MUSCULOSKELETAL MOVEMENT DEFICIENCIES

49974615_US

49945755_US,50061281_US,49979708_RS,49870683_AU

G06T 7/251,G06T 11/60,G06T2207/10016,G06T2207/20221,G06T2210/41,G16H 20/30,G16H 30/20,G16H 40/67

[ "G06T 7/20", "G06T 11/60", "G06F 19/00" ]

93,364

423,752,329

2013-02-11

51,870,132

Y

Methods for measuring B1 values in an MRI sample space, generating B1 maps and using B1 maps to correct B1 profiles are disclosed.

en

Methods of radio frequency magnetic field mapping

5486677_CA

48276824_CA,48293269_CA,48315125_CA,7213518_CA

G01R 33/246,G01R 33/5659

[ "G01V 3/00", "G01R 33/565" ]

90,084

16,604,798

1985-12-04

24,728,543

N

N-1-subs@@tuted-6-n-propyl-8 beta -methylthiomethylergoline@@e D-2 agonists which do not interact with alpha adrenergi@receptors.

en

Ergoline derivatives.

11700_US

2514350_US

A61P 9/12,A61P 13/02,A61P 15/00,A61P 25/00,A61P 25/24,A61P 25/26,C07D 457/02

[ "A61P 9/12", "A61K 31/48", "A61P 25/26", "A61P 15/00", "A61P 25/24", "C07D 457/02", "A61P 25/00", "A61P 13/02" ]

17,442

547,031,631

2020-09-08

74,850,979

N

Methods and systems for determining epistemic and aleatoric uncertainties using a dual neural network architecture are described.

en

DUAL NEURAL NETWORK ARCHITECTURE FOR DETERMINING EPISTEMIC AND ALEATORIC UNCERTAINTIES

5212098_US

53638273_US,79528797_CH,9817154_US

G06K 9/6259,G06K 9/6271,G06K 9/6278,G06N 3/0454,G06N 3/0472,G06N 3/08,G06N 3/082,G06N 3/084,G06N 5/04

[ "G06N 3/08", "G06N 5/04", "G06N 3/04", "G06K 9/62" ]

150,839

49,066,923

2003-01-27

7,638,473

Y

A neural network is used to obtain more robust performance in determining prosodic markers on the basis of linguistic categories.

en

Method and device for determining prosodic markers by neural autoassociators

5210496_DE

7180084_DE,7180083_DE

G10L 13/10,G10L 25/30

[ "G10L 25/30", "G10L 15/16", "G10L 13/10" ]

38,192

506,164,576

2018-07-13

64,998,690

Y

Real-time systems for monitoring base editing in living cells, including base editing by APOBEC-Cas9 fusions, is provided herein.

en

Real-time reporter systems for monitoring base editing

5502132_US

74710601_US,8319913_US,74818880_US

C07K 14/00,C07K 14/43504,C07K 14/43595,C07K 16/12,C07K 16/18,C07K2317/24,C07K2319/00,C07K2319/60,C12N 9/22,C12N 9/78,C12N 15/102,C12N 15/63,C12N 15/635,C12N 15/86,C12N2310/20,C12N2740/16043

[ "C07K 16/12", "C12N 15/10", "C07K 14/00", "C07K 14/435", "C07K 16/18", "C12N 15/00", "C12N 15/86", "C12N 9/22", "C12N 9/78", "C12N 15/63" ]

124,298

511,627,344

2016-09-04

66,174,827

Y

The exemplary embodiments present a system for easy and rapid communication, display, and comparison of object-directed feelings.

en

System for communication of object-directed feelings

69963388_US

G06F 16/24575,G06F 16/248,G06F 16/285,G06Q 50/01

[ "G06F 16/2457", "G06F 16/28", "G06F 16/248" ]

127,207

46,830,626

2002-02-14

23,022,675

Y

The present invention relates to a method of treating or preventing cerebral vasospasm that accompanies sub-arachnoid hemorrhage.

en

Therapy for cerebral vasospasm

5219375_US

5932470_US,5932468_US,5932469_US

A61K 31/00,A61K 38/005,A61K 38/482,A61K 38/4886,A61K2039/505,C07K 16/22,C07K2317/73,G01N 33/5088,G01N2333/78

[ "C07D 471/04", "C07D 471/22", "A61K 31/497", "C07D 487/04" ]

32,850

4,226,934

1985-06-11

25,822,036

Y

NAPHTHOXAZINES 3,4,4a,5,10,10a-hexahydro-2H-naphth¢2,3-b!-1,4-oxazines are useful as psychostimulating and antidepressant agents.

en

NAPHTHOXAZINES

12559364_DE

12559364_DE,16131203_DE

A61P 25/24,A61P 25/26,C07C 247/00,C07D 265/34,C07D 303/22

[ "A61K", "C07D 265/34", "C07C 247/14", "C07C 241/00", "C07C 217/74", "C07D", "C07D 303/22", "A61K 31/538", "A61K 31/535", "C07C 215/44", "C07D 303/14", "C07C 213/00", "A61P 25/26", "A61P 25/24", "C07D 265/36", "C07C 233/23", "C07C 67/00" ]

3,607

500,792,159

2018-03-30

63,672,361

N

The present invention relates to generally to a system for improving neuroplasticity and recovery for a patient in need thereof.

en

System of Improving Neuroplasticity and Recovery during Occupational, Physical, and Related Therapies

58074678_US

57975208_SE,58073283_US

A61B 5/18,A61B 5/4088,A63F 13/211,A63F 13/212,A63F 13/25,A63F 13/50,A63F 13/5255,A63F 13/80,G09B 5/062,G09B 19/00,G16H 20/30,G16H 20/70

[ "A63F 13/50", "G09B 19/00", "A61B 5/00", "G09B 5/06", "G16H 20/70", "A63F 13/80" ]

121,321

57,300,422

2008-11-09

40,626,218

N

Tetrahydroindolone and aryl piperazine derivatives for use in treating post-traumatic stress disorder and acute stress disorder.

en

TREATMENT OF POST-TRAUMATIC STRESS DISORDER WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS

40676537_US,40676539_US,40676540_US,40676538_US

40676540_US,40676538_US,40676539_US

A61K 31/497,A61P 25/00

[ "A61K 31/497" ]

55,957

196,167

2007-02-15

36,141,991

N

Compounds of the formula (I), inhibit D-amino acid oxidase and hence find use in treating degenerative and psychiatric diseases.

en

3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES

86853_GB,134090_US

288926_GB,288924_US,288925_GB,288927_GB

A61K 31/415,A61K 31/4155,A61P 25/28,C07D 231/06,C07D 401/04

[ "A61K 31/4155", "C07D 401/04", "A61K 31/415", "C07D 231/06" ]

1,054

512,773,613

2018-12-20

62,906,142

Y

Systems and methods for neutron detection using tensioned metastable fluid detectors, using a single atom spectroscopy approach.

en

Fast neuron spectroscopy with tensioned metastable fluid detectors

5210860_US

56915401_US,56954886_US

G01T 3/00,G01T 3/001,G01T 5/06

[ "G01T 5/06", "G01T 3/00" ]

127,808

266,850,843

2009-02-19

40,997,649

Y

A magnetic resonance imaging (MRI) method of obtaining MRI images of a patient and storing the images in physical storage media.

en

Arterial spin labeled, segmented, interleaved 3D GRASE MRI

6507281_US,11100304_US,11100303_US

11100304_US,11100303_US

G01R 33/4818,G01R 33/4822,G01R 33/4833,G01R 33/5618,G01R 33/56366,G01R 33/56536,G01R 33/56554,G01R 33/56563

[ "G01V 3/00", "G01R 33/54" ]

57,483

51,672,272

2005-06-16

20,289,905

Y

Selective phenyl substituted aminopyrazine inhibitors of GSK3 useful for the prevention and/or treatment of cognitive disorders.

en

Compounds having selective inhibiting effect at GSK3

5219843_SE,6045944_SE,6045942_SE,8707134_SE

8707134_SE,6045942_SE,6045944_SE

A61P 3/10,A61P 5/48,A61P 13/12,A61P 15/18,A61P 17/02,A61P 17/14,A61P 25/00,A61P 25/02,A61P 25/16,A61P 25/18,A61P 25/24,A61P 25/28,C07D 211/56,C07D 241/26,C07D 295/073,C07D 295/26,C07D 401/12,C07D 401/14,C07D 403/12,C07D 403/14

[ "A61P 25/00", "C07D 419/00", "A61K 31/497", "C07D 241/26", "C07D 295/073", "C07D 211/56", "C07D 405/00", "C07D 401/00", "C07D 295/26", "C07D 241/02", "C07D 403/00", "C07D 417/00", "C07D 401/12", "C07D 401/14", "C07D 409/00", "C07D 403/14", "C07D 403/02", "C07D 403/12", "C07D 413/00", "C07D 411/00", "A61K 31/50", "A61K 31/501", "A61P 15/18", "A61P 17/14", "A61P 5/48", "A61P 3/10" ]

42,561

48,619,985

1988-06-06

27,394,451

Y

Potent DBH Inhibitors having the formula: <IMAGE> wherein R is -CO2H or -CH2NHR1 can be used to inhibit DBH activity in mammals.

en

Dopamine- beta -hydroxylase inhibitors

5246023_US

6826979_US,5261317_US

C07D 501/20

[ "C07D 233/90", "C07D 233/64", "C07D 233/04" ]

37,491

53,024,497

1985-04-16

27,047,874

Y

Potent DBH Inhibitors having the formula: <IMAGE> wherein R is -CO2H or -CH2NHR1 can be used to inhibit DBH activity in mammals.

en

Dopamine beta -hydroxylase inhibitors

5246023_US

6826979_US,5246024_US,5261317_US

C07C 217/62,C07D 233/64,C07D 233/84,C07D 233/90

[ "C07D 233/90", "C07D 233/84", "C07D 233/54", "C07C 217/62" ]

45,158

51,720,081

2006-10-10

38,534,522

Y

The invention relates, in part, to methods of administering electrical or magnetic brain stimulation to increase learning rate.

en

Methods of increasing learning rate

5219722_US,8747666_US,8747667_US

8747666_US,8747667_US

A61N 1/36025,A61N 1/36082,A61N 2/004

[ "A61N 1/00" ]

42,646

51,707,039

1990-06-25

27,397,911

Y

Radioiodine 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine derivatives and their use as brain imaging agents.

en

Radioiodine benzodiazepines as brain imaging agents

5803590_US

8736566_AT,5743674_CH

A61K 51/047,A61K2123/00

[ "A61K 51/04" ]

42,617

315,436,943

2009-11-18

39,225,245

Y

A method of reducing the incidences of bupropion induced seizures by coadministration of a bromide salt with a bupropion salt.

en

Bupropion hydrobromide and therapeutic applications

10154985_CA,10154984_IE,11016441_BM

10154984_IE,10154985_CA

A61K 9/2846,A61K 9/2866,A61K 9/2886,A61K 31/135,A61K 33/00,A61P 3/04,A61P 25/08,A61P 25/24,A61P 25/34

[ "A61K 9/28", "A61K 9/24", "A61K 31/135", "A61K 31/137", "A61P 25/08" ]

61,547

49,546,266

1981-10-26

6,115,503

Y

The decapeptide of the formula H-Ser-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-OH and the use thereof as hapten, tracer or antibody.

en

Decapeptide

7514144_DE

5482617_AT,7514140_DE,7514145_DE,6454011_DE

C07K 14/555,C07K 16/249,G01N 33/531,G01N 33/58,Y10S 530/806,Y10S 930/142

[ "C07K 14/52", "G01N 33/58", "C07K 7/06", "G01N 33/531", "C07K 14/555", "C07K 19/00", "C07K 16/24" ]

38,952

54,366,199

2004-10-15

34,681,396

Y

A method and apparatus for ascertaining the cerebral state of a patient using generalized spectral entropy of the EEG signal.

en

Method and apparatus for determining the cerebral state of a patient using generalized spectral entropy of the EEG signal

5258508_FI

6661311_FI

A61B 5/374,A61B 5/7203,A61B 5/7257

[ "A61B 5/374" ]

48,937

481,732,729

2017-01-26

45,464,626

Y

The invention relates to a method of differentially diagnosing schizophrenia, bipolar disorder and major depressive disorder.

en

Quantifying biomarkers for diagnosing and treating schizophrenia, bipolar disorder or major depression

5625935_GB

8843796_GB,11806623_GB

G01N 33/50,G01N 33/52,G01N 33/5308,G01N 33/573,G01N 33/6893,G01N 33/6896,G01N2333/96494,G01N2800/28,G01N2800/2814,G01N2800/30,G01N2800/302,G01N2800/304

[ "G01N 33/573", "G01N 33/53", "G01N 33/52", "G01N 33/50" ]

110,442

17,451,867

1999-10-29

22,312,313

Y

A combination of a 5HT1B/1D agonist and a COX-2 selective inhibitor is useful in the treatment and or prevention of migraine.

en

COMBINATIONS OF A 5HT1B/1D AGONIST AND A SELECTIVE COX-2 INHIBITOR FOR THE TREATMENT OF MIGRAINE

34620_US

4063230_US,4063232_US,4063228_US,4063229_US,4063231_US,4063233_US

A61K 31/40,A61K 31/415,A61K 31/42,A61K 31/54,A61K 45/06,A61P 25/06

[ "A61K 31/42", "A61K 31/4196", "A61K 31/404", "A61K 31/421", "A61K 45/06", "A61P 25/06", "A61K 31/422", "A61K 31/5415", "A61K 31/454" ]

21,013

50,787,462

1995-04-17

26,299,069

Y

4-(Fluorobenzoylamino)-3,4-dihydro-benzopyran derivatives are disclosed to possess anxiolytic and anti-convulsant activities.

en

Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity

5307715_GB

8079751_GB,8079753_GB,8079752_GB

C07D 215/48,C07D 311/68,C07D 311/70,C07D 311/72,C07D 491/04

[ "C07D 215/48", "C07D 311/68", "C07D 311/70", "C07D 491/04", "C07D 311/72" ]

40,686

53,291,063

1977-01-19

24,730,617

Y

2-Piperidinoalkyl-1,4-benzodioxans, e.g. those of the formula <IMAGE> and acid addition salts thereof are neuroleptic agents.

en

Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans

5232729_US

5403685_US

C07D 409/14

[ "C07D 409/14" ]

45,705

54,570,421

2005-10-19

36,203,725

N

Discrete and diffuse defects in a surface are detected. Discrete defects that may compromise the performance may be repaired.

en

BIOMOLECULAR RECOGNITION OF CRYSTAL DEFECTS

39764209_US,33315314_US,5298000_US

39764209_US,33315314_US

A61L 33/12,B05D 1/02,B05D 3/00,B05D 5/005,B32B 43/00,C07K 7/06,C23C 18/1608,C23C 18/1692,C23C 18/1831,C23C 18/1834,C23C 18/1879,C23C 18/1882,G01N 33/6845,H01L 21/28

[ "B05D 3/00", "B05D 1/02", "A61L 33/12", "B32B 43/00" ]

50,617

501,683,598

2018-04-11

63,792,506

N

The present invention uses an autoantibody to a small unmyelinated dorsal root ganglion neuron as a neuropathic pain marker.

en

NEUROPATHIC PAIN MARKER AND USE THEREOF

64085581_JP

64105875_JP,66929767_JP,69111422_JP,64058432_JP,64136173_JP,69114894_JP

G01N 33/53

[ "G01N 33/53" ]

121,715

51,481,304

2005-10-21

29,584,413

Y

Methods and kits for treating inflammatory conditions are described that include modulating kallikrein 6 protease activity.

en

Method of treating multiple sclerosis with anti-K6 antibody

5350306_US,8546311_US,5795316_US,8546312_US,8546310_US,5219690_US

8546311_US,8546310_US,8546312_US,5350306_US

A61K 39/3955,A61K2039/57,A61P 11/06,A61P 37/00,C07K 16/40,C07K2317/76,C12Q 1/37,C12Q 1/6883,C12Q2600/158,G01N 33/564,G01N2333/96455,G01N2800/102,G01N2800/104,G01N2800/24,G01N2800/285

[ "G01N 33/564", "G01N 33/53", "C12Q 1/37", "C12N 9/64", "C07K 16/40", "A61K 48/00", "C12Q 1/68", "C07H 21/02", "A61K 39/395" ]

42,174

49,354,534

1972-09-18

26,668,431

Y

The compounds are 1,4-diaminobut-2-yne derivatives of pyrrolidinone which are useful as central nervous system depressants.

en

CYCLIC AMIDES OF 1,4-DIAMINOBUT-2-YNE

26137214_

38402502_,38468140_

C07D 207/26,C07D 207/27

[ "C07D 207/27", "C07D 207/26" ]

38,619

48,689,267

1980-11-28

26,754,084

Y

Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s are useful as anti-depressants, tranquilizers, analgesics and anticonvulsants.

en

3''-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1''-(3''H)-isobenzofuran]

6882847_US

5922592_DE,5307138_US

C07D 263/14,C07D 307/94,C07D 493/10

[ "C07D 263/14", "C07D 493/10", "C07D 307/94" ]

37,599

50,456,184

2006-05-12

37,525,059

Y

Devices and methods to treat atrial fibrillation via inhibition of nerves which innervate the pulmonary vein are provided.

en

Neurotoxic agents and devices to treat atrial fibrillation

5224734_US,5329999_US

5329999_US

A61N 1/057,A61N 1/0575,A61N 1/3625

[ "A61M 29/00", "A61M 31/00", "A61N 1/00" ]

40,052

446,052,309

2012-06-08

44,189,204

N

Automated behavioral methods and systems for treating Insomnia that use passive means for determining wake I sleep states.

en

'AUTOMATED TREATMENT SYSTEM FOR SLEEP'

52275672_US

51816898_US,52032948_US,52229570_US

A61B 5/4809,A61M 21/00,A61M2021/0016,A61M2021/0022,A61M2021/0027,A61M2021/0072,A61M2230/10,A61M2230/18,A61M2230/42,A61M2230/60,A61M2230/63,A61M2230/65

[ "A47J" ]

97,177

48,513,129

1971-10-14

4,414,035

Y

A method for preparing N-benzyloxycarbonyl-dopa derivatives useful as hypotensive, anti-pyretic and anti-Parkinson agents.

en

N-BENZYLOXYCARBONYL-DOPA DERIVATIVES

37221778_

38243830_,38243829_,38243831_,34931839_

C07F 5/04,Y10S 514/916

[ "C07F 5/04" ]

37,311

404,768,022

2011-07-22

45,530,007

N

Existing pain-relief devices have the problem that the use thereof requires specialized knowledge of Eastern acupuncture,

en

Pain-relief device

6428373_JP

44399623_,13871493_

A61H 39/06,A61H2201/0153,A61H2201/10,A61H2201/50,A61H2201/5028,A61H2201/5043,A61H2201/5058,A61N 5/0619,A61N 5/067,A61N2005/0644,A61N2005/0659

[ "A61N 5/06", "A61H 39/00" ]

78,699

4,053,702

1977-03-04

24,673,972

Y

Nonionic triiodobenzoyl amino acyl derivatives of polyhydroxy amines which are useful as nonionic X-ray contrast agents.

en

N-TRIIODO-BENZOYLAMINOACYL POLYHYDROXIC AMINES

7760213_

15963531_

C07C 233/12

[ "C07C 237/46", "C07C 311/00", "C07C 67/00", "C07C 303/40", "C07C 231/00", "A61K 31/165", "C07C 301/00", "C07C 233/12", "A61K 49/04", "C07C 231/02" ]

3,306