prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Hlx in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Hlx
|
cell cycle progression
|
breast epithelium
|
Gene: Hlx (H2.0-like homeobox)
Type: protein-coding
Summary: Predicted to enable sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic digestive tract morphogenesis; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; genitourinary system; and gut. Orthologous to human HLX (H2.0 like homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: animal organ development, cell differentiation, embryonic digestive tract morphogenesis, enteric nervous system development, liver development, negative regulation of T-helper 2 cell differentiation, positive regulation of T-helper 1 cell differentiation, positive regulation of epithelial cell proliferation, positive regulation of organ growth, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal muscle tissue development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, sequence-specific DNA binding
Pathways:
UniProt: Q61670
Entrez ID: 15284
|
Does Knockout of Snrnp48 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Snrnp48
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Snrnp48 (small nuclear ribonucleoprotein 48 (U11/U12))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, biological_process, mRNA processing; MF: metal ion binding, molecular_function, zinc ion binding; CC: U12-type spliceosomal complex, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q9D361
Entrez ID: 67797
|
Does Knockout of Vmn2r96 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Vmn2r96
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Vmn2r96 (vomeronasal 2, receptor 96)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: H3BJR5, E9PZU5, A0A338P747
Entrez ID: 433070
|
Does Knockout of Srpk3 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Srpk3
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Srpk3 (serine/arginine-rich protein specific kinase 3)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity. Involved in muscle tissue development. Acts upstream of or within protein phosphorylation and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Is expressed in tail mesenchyme; tongue; and vertebral axis musculature. Orthologous to human SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, intracellular signal transduction, muscle organ development, muscle tissue development, regulation of mRNA processing, skeletal muscle tissue development, spliceosomal complex assembly; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9Z0G2
Entrez ID: 56504
|
Does Knockout of Papss1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Papss1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Papss1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process, sulfate assimilation; MF: ATP binding, adenylylsulfate kinase activity, catalytic activity, kinase activity, nucleotide binding, nucleotidyltransferase activity, protein homodimerization activity, sulfate adenylyltransferase (ATP) activity, transferase activity; CC: cytoplasm, cytosol, nucleus, sulfate adenylyltransferase complex (ATP)
Pathways: Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Purine metabolism - Mus musculus (mouse), Selenocompound metabolism - Mus musculus (mouse), Sulfur metabolism - Mus musculus (mouse), Transport and metabolism of PAPS, sulfate activation for sulfonation, sulfur metabolism
UniProt: Q60967
Entrez ID: 23971
|
Does Knockout of Mcm7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Mcm7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mcm7 (minichromosome maintenance complex component 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA replication, DNA replication initiation, DNA strand elongation involved in DNA replication, cell population proliferation, cellular response to epidermal growth factor stimulus, cellular response to xenobiotic stimulus, double-strand break repair via break-induced replication, premeiotic DNA replication, response to xenobiotic stimulus; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromosome, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), DNA Replication, DNA Replication Pre-Initiation, DNA replication - Mus musculus (mouse), G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA
UniProt: Q61881
Entrez ID: 17220
|
Does Knockout of Papolg in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Papolg
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Papolg (poly(A) polymerase gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA 3'-end processing, mRNA processing; MF: ATP binding, RNA binding, metal ion binding, nucleotide binding, nucleotidyltransferase activity, poly(A) RNA polymerase activity, transferase activity; CC: cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Nuclear RNA decay, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q6PCL9
Entrez ID: 216578
|
Does Knockout of Ceacam12 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ceacam12
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ceacam12 (CEA cell adhesion molecule 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell activation, immune response, phagocytosis; CC: cellular_component, external side of plasma membrane
Pathways:
UniProt: Q9DAS5, Q3V2Q3, Q3UKP4, Q9DAZ3
Entrez ID: 67315
|
Does Knockout of Syp in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Syp
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Syp (synaptophysin)
Type: protein-coding
Summary: Enables SH2 domain binding activity and identical protein binding activity. Involved in regulation of long-term neuronal synaptic plasticity; regulation of short-term neuronal synaptic plasticity; and regulation of synaptic vesicle priming. Located in several cellular components, including neuromuscular junction; presynaptic membrane; and synaptic vesicle membrane. Is active in Schaffer collateral - CA1 synapse and presynaptic active zone. Is expressed in several structures, including diaphragm; gut; nervous system; sensory organ; and skeletal muscle. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to human SYP (synaptophysin). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: chemical synaptic transmission, endocytosis, modulation of chemical synaptic transmission, protein homooligomerization, regulation of long-term neuronal synaptic plasticity, regulation of neuronal synaptic plasticity, regulation of opioid receptor signaling pathway, regulation of short-term neuronal synaptic plasticity, regulation of synaptic vesicle priming; MF: SH2 domain binding, SNARE binding, cholesterol binding, identical protein binding, protein binding, protein domain specific binding, protein-containing complex binding, syntaxin-1 binding; CC: Schaffer collateral - CA1 synapse, clathrin-sculpted glutamate transport vesicle membrane, cytoplasmic vesicle, excitatory synapse, membrane, neuromuscular junction, neuron projection, neuron projection terminus, neuron spine, perinuclear region of cytoplasm, postsynaptic density, presynapse, presynaptic active zone, presynaptic membrane, protein-containing complex, synapse, synaptic vesicle, synaptic vesicle membrane, terminal bouton
Pathways:
UniProt: Q62277
Entrez ID: 20977
|
Does Knockout of Phf5a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Phf5a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Phf5a (PHD finger protein 5A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, stem cell differentiation; MF: DNA binding, RNA binding, metal ion binding, protein binding, zinc ion binding; CC: U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nuclear matrix, nuclear speck, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P83870
Entrez ID: 68479
|
Does Knockout of Tas2r124 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tas2r124
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tas2r124 (taste receptor, type 2, member 124)
Type: protein-coding
Summary: Predicted to enable bitter taste receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste and positive regulation of cytokinesis. Predicted to be active in membrane. Orthologous to human TAS2R13 (taste 2 receptor member 13). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, positive regulation of cytokinesis, sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity; CC: membrane
Pathways: Taste transduction - Mus musculus (mouse)
UniProt: Q7M718
Entrez ID: 387351
|
Does Knockout of Skor2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Skor2
|
response to virus
|
Microglial Cell Line
|
Gene: Skor2 (SKI family transcriptional corepressor 2)
Type: protein-coding
Summary: Enables SMAD binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; regulation of neural precursor cell proliferation; and regulation of signal transduction. Located in nucleus. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human SKOR2 (SKI family transcriptional corepressor 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell development, cerebellar Purkinje cell differentiation, cerebellum morphogenesis, negative regulation of BMP signaling pathway, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of smoothened signaling pathway, regulation of cerebellar granule cell precursor proliferation, regulation of dendrite morphogenesis, regulation of neuroblast proliferation; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SMAD binding, chromatin binding, histone deacetylase binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: A7M7C7
Entrez ID: 664805
|
Does Knockout of Coa6 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Coa6
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Coa6 (cytochrome c oxidase assembly factor 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, respiratory chain complex IV assembly; MF: copper ion binding; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm
Pathways: Thermogenesis - Mus musculus (mouse)
UniProt: Q8BGD8
Entrez ID: 67892
|
Does Knockout of Txndc17 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Txndc17
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Txndc17 (thioredoxin domain containing 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular oxidant detoxification, tumor necrosis factor-mediated signaling pathway; MF: peroxidase activity, protein-disulfide reductase [NAD(P)H] activity; CC: cytoplasm, cytosol
Pathways:
UniProt: Q9CQM5
Entrez ID: 52700
|
Does Knockout of Srr in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Srr
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Srr (serine racemase)
Type: protein-coding
Summary: Enables several functions, including amino-acid racemase activity; anion binding activity; and identical protein binding activity. Acts upstream of or within D-serine biosynthetic process and L-serine metabolic process. Predicted to be located in apical part of cell and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in facial bone primordium and nervous system. Used to study schizophrenia. Orthologous to human SRR (serine racemase). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: D-serine biosynthetic process, D-serine metabolic process, L-serine metabolic process, amino acid metabolic process, pyruvate biosynthetic process, response to ketamine, response to lipopolysaccharide, response to xenobiotic stimulus; MF: ATP binding, D-serine ammonia-lyase activity, L-serine ammonia-lyase activity, PDZ domain binding, calcium ion binding, catalytic activity, glycine binding, identical protein binding, isomerase activity, lyase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, pyridoxal phosphate binding, serine racemase activity, threonine racemase activity; CC: apical part of cell, cytoplasm, neuronal cell body
Pathways: Glycine, serine and threonine metabolism - Mus musculus (mouse), Metabolism, Metabolism of amino acids and derivatives, Serine metabolism
UniProt: Q9QZX7
Entrez ID: 27364
|
Does Knockout of Riok1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,262
|
Knockout
|
Riok1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Riok1 (RIO kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the RIO family of atypical serine protein kinases. A similar protein in humans is a component of the protein arginine methyltransferase 5 complex that specifically recruits the RNA-binding protein nucleolin as a methylation substrate. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: maturation of SSU-rRNA, positive regulation of rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, catalytic activity, hydrolase activity, kinase activity, metal ion binding, nucleotide binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, methyltransferase complex, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q922Q2
Entrez ID: 71340
|
Does Knockout of Gtf2a1l in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Gtf2a1l
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gtf2a1l (general transcription factor IIA, 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cognition, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, protein binding; CC: cytoplasm, male germ cell nucleus, nucleus, transcription factor TFIIA complex
Pathways: Basal transcription factors - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q8R4I4
Entrez ID: 71828
|
Does Knockout of Rab8a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rab8a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rab8a (RAB8A, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, Golgi vesicle fusion to target membrane, autophagy, axonogenesis, cell projection organization, cellular response to insulin stimulus, cilium assembly, endocytic recycling, exocytosis, neurotransmitter receptor transport to postsynaptic membrane, neurotransmitter receptor transport, endosome to postsynaptic membrane, protein localization to cilium, protein localization to plasma membrane, protein transport, regulation of autophagy, regulation of long-term neuronal synaptic plasticity, regulation of protein localization, regulation of protein transport, vesicle docking involved in exocytosis, vesicle-mediated transport in synapse; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, myosin V binding, nucleotide binding, protein binding, protein kinase binding, protein tyrosine kinase binding, small GTPase binding; CC: Golgi apparatus, actin cytoskeleton, cell projection, centriolar satellite, centriole, centrosome, ciliary basal body, ciliary base, ciliary membrane, cilium, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, dendrite, endomembrane system, endosome, endosome membrane, glutamatergic synapse, lysosome, membrane, midbody, neuron projection, neuronal cell body, non-motile cilium, nucleolus, nucleoplasm, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, recycling endosome, recycling endosome membrane, synapse, synaptic vesicle, trans-Golgi network transport vesicle
Pathways: AMPK signaling pathway - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Autophagy - animal - Mus musculus (mouse), Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cilium Assembly, Endocytosis - Mus musculus (mouse), G2/M Transition, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Organelle biogenesis and maintenance, Pancreatic secretion - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Regulation of PLK1 Activity at G2/M Transition, TBC/RABGAPs, Tight junction - Mus musculus (mouse), Vesicle-mediated transport, VxPx cargo-targeting to cilium
UniProt: P55258
Entrez ID: 17274
|
Does Knockout of Lrrc20 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Lrrc20
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lrrc20 (leucine rich repeat containing 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CI70
Entrez ID: 216011
|
Does Knockout of Nars2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Nars2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nars2 (asparaginyl-tRNA synthetase 2 (mitochondrial)(putative))
Type: protein-coding
Summary: Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in embryo; extraembryonic component; and primitive endoderm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: asparaginyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, asparagine-tRNA ligase activity, ligase activity, nucleic acid binding, nucleotide binding; CC: cytosol, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8BGV0
Entrez ID: 244141
|
Does Knockout of Sirt1 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Sirt1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Sirt1 (sirtuin 1)
Type: protein-coding
Summary: This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA damage response, DNA repair-dependent chromatin remodeling, DNA synthesis involved in DNA repair, UV-damage excision repair, angiogenesis, apoptotic process, attachment of mitotic spindle microtubules to kinetochore, behavioral response to starvation, cardiac muscle cell apoptotic process, cell differentiation, cellular response to amyloid-beta, cellular response to glucose starvation, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to ionizing radiation, cellular response to leukemia inhibitory factor, cellular response to resveratrol, cellular response to starvation, cellular response to tumor necrosis factor, cholesterol homeostasis, chromatin organization, circadian regulation of gene expression, circadian rhythm, endoplasmic reticulum unfolded protein response, energy homeostasis, fatty acid homeostasis, gluconeogenesis, heterochromatin formation, hippo signaling, intracellular glucose homeostasis, intracellular triglyceride homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, leptin-mediated signaling pathway, macrophage differentiation, maintenance of nucleus location, muscle organ development, negative regulation of DNA damage response, signal transduction by p53 class mediator, negative regulation of DNA-templated transcription, negative regulation of NF-kappaB transcription factor activity, negative regulation of TOR signaling, negative regulation of androgen receptor signaling pathway, negative regulation of apoptotic process, negative regulation of attachment of mitotic spindle microtubules to kinetochore, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell cycle, negative regulation of cellular response to testosterone stimulus, negative regulation of cellular senescence, negative regulation of fat cell differentiation, negative regulation of fibroblast apoptotic process, negative regulation of gene expression, negative regulation of growth hormone secretion, negative regulation of hippo signaling, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of peptidyl-lysine acetylation, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of phosphorylation, negative regulation of prostaglandin biosynthetic process, negative regulation of protein localization to nucleus, negative regulation of reactive oxygen species biosynthetic process, negative regulation of signal transduction by p53 class mediator, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of triglyceride biosynthetic process, negative regulation of tumor necrosis factor production, neuron apoptotic process, ovulation from ovarian follicle, positive regulation of DNA repair, positive regulation of MHC class II biosynthetic process, positive regulation of adaptive immune response, positive regulation of adipose tissue development, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of blood vessel endothelial cell migration, positive regulation of cAMP-dependent protein kinase activity, positive regulation of cell growth involved in cardiac muscle cell development, positive regulation of cell population proliferation, positive regulation of cellular senescence, positive regulation of cholesterol efflux, positive regulation of double-strand break repair, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of endothelial cell proliferation, positive regulation of gluconeogenesis, positive regulation of heart rate, positive regulation of insulin receptor signaling pathway, positive regulation of insulin secretion involved in cellular response to glucose stimulus, positive regulation of macroautophagy, positive regulation of macrophage apoptotic process, positive regulation of macrophage cytokine production, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein phosphorylation, positive regulation of skeletal muscle cell proliferation, positive regulation of smooth muscle cell differentiation, positive regulation of thyroid-stimulating hormone secretion, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein deacetylation, protein depropionylation, protein destabilization, protein ubiquitination, pyrimidine dimer repair by nucleotide-excision repair, rDNA heterochromatin formation, regulation of apoptotic process, regulation of bile acid biosynthetic process, regulation of brown fat cell differentiation, regulation of cell population proliferation, regulation of centrosome duplication, regulation of endodeoxyribonuclease activity, regulation of glucose metabolic process, regulation of lipid storage, regulation of mitotic cell cycle, regulation of multicellular organismal process, regulation of peroxisome proliferator activated receptor signaling pathway, regulation of smooth muscle cell apoptotic process, regulation of transcription by glucose, response to ethanol, response to hydrogen peroxide, response to insulin, response to leptin, response to oxidative stress, rhythmic process, signal transduction by p53 class mediator, single strand break repair, spermatogenesis, stress-induced premature senescence, subtelomeric heterochromatin formation, transforming growth factor beta receptor signaling pathway, tricarboxylic acid metabolic process, triglyceride biosynthetic process, triglyceride mobilization, vasodilation, white fat cell differentiation; MF: DNA-binding transcription factor binding, HLH domain binding, NAD+ binding, NAD-dependent protein decrotonylase activity, NAD-dependent protein lysine deacetylase activity, NAD-dependent protein lysine delactylase activity, NAD-dependent protein-lysine depropionylase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, bHLH transcription factor binding, deacetylase activity, enzyme activator activity, enzyme binding, enzyme inhibitor activity, histone H3K deacetylase activity, histone H3K14 deacetylase activity, NAD-dependent, histone H3K9 deacetylase activity, NAD-dependent, histone H4K12 deacetylase activity, hydrolytic mechanism, histone H4K16 deacetylase activity, NAD-dependent, histone binding, histone deacetylase activity, histone deacetylase activity, NAD-dependent, histone decrotonylase activity, NAD-dependent, identical protein binding, keratin filament binding, metal ion binding, mitogen-activated protein kinase binding, nuclear receptor binding, p53 binding, promoter-specific chromatin binding, protein binding, protein domain specific binding, protein kinase B binding, protein lysine deacetylase activity, transcription coactivator activity, transcription corepressor activity, transcription regulator inhibitor activity, transferase activity; CC: ESC/E(Z) complex, PML body, axon, chromatin, chromatin silencing complex, chromosome, telomeric region, cytoplasm, cytosol, eNoSc complex, euchromatin, fibrillar center, growth cone, heterochromatin, mitochondrion, nuclear envelope, nuclear inner membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, rDNA heterochromatin
Pathways: AMPK signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Developmental Biology, FOXO-mediated transcription, FoxO signaling pathway - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MITF-M-regulated melanocyte development, MicroRNAs in cancer - Mus musculus (mouse), Nicotinate and nicotinamide metabolism - Mus musculus (mouse), RNA Polymerase II Transcription, Regulation of FOXO transcriptional activity by acetylation, Regulation of HSF1-mediated heat shock response, Transcriptional and post-translational regulation of MITF-M expression and activity
UniProt: Q923E4
Entrez ID: 93759
|
Does Knockout of Cldnd2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Cldnd2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Cldnd2 (claudin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9D9H2
Entrez ID: 74276
|
Does Knockout of Flt3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Flt3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Flt3 (FMS-like tyrosine kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell differentiation, animal organ development, antigen processing and presentation, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, cellular response to cytokine stimulus, cellular response to virus, common myeloid progenitor cell proliferation, cytokine-mediated signaling pathway, dendritic cell differentiation, dendritic cell homeostasis, hemopoiesis, homeostasis of number of cells within a tissue, leukocyte homeostasis, lymph node development, lymphocyte differentiation, lymphocyte proliferation, lymphoid progenitor cell differentiation, myeloid progenitor cell differentiation, negative regulation of B cell differentiation, negative regulation of cell population proliferation, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production, positive regulation of cell population proliferation, positive regulation of interferon-alpha production, positive regulation of interleukin-12 production, positive regulation of macromolecule metabolic process, positive regulation of multicellular organism growth, positive regulation of type II interferon production, post-embryonic development, pro-B cell differentiation, pro-T cell differentiation, spleen development, system development; MF: ATP binding, cytokine receptor activity, growth factor binding, kinase activity, nuclear glucocorticoid receptor binding, nucleotide binding, phosphatidylinositol 3-kinase binding, protein binding, protein kinase activity, protein tyrosine kinase activity, protein-containing complex binding, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane signaling receptor activity, ubiquitin protein ligase binding; CC: cell surface, endoplasmic reticulum, endoplasmic reticulum lumen, external side of plasma membrane, membrane, plasma membrane, protein-containing complex, receptor complex
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Cytokine Signaling in Immune system, FLT3 Signaling, FLT3 signaling through SRC family kinases, Hematopoietic cell lineage - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Negative regulation of FLT3, Negative regulation of the PI3K/AKT network, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), RAF/MAP kinase cascade, Ras signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q00342
Entrez ID: 14255
|
Does Knockout of Tll1 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Tll1
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Tll1 (tolloid-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, dorsal/ventral pattern formation, protein processing, proteolysis; MF: calcium ion binding, collagen binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular region, extracellular space
Pathways:
UniProt: A0A1B0GRW8, G3X9F5
Entrez ID: 21892
|
Does Knockout of Hspd1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Hspd1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Hspd1 (heat shock protein 1 (chaperonin))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, B cell proliferation, MyD88-dependent toll-like receptor signaling pathway, T cell activation, adhesion of symbiont to host, apoptotic mitochondrial changes, biological process involved in interaction with symbiont, cellular response to interleukin-7, isotype switching to IgG isotypes, mitochondrial unfolded protein response, negative regulation of apoptotic process, negative regulation of execution phase of apoptosis, positive regulation of T cell activation, positive regulation of T cell mediated immune response to tumor cell, positive regulation of cytokine production, positive regulation of execution phase of apoptosis, positive regulation of interferon-alpha production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of macrophage activation, positive regulation of type II interferon production, protein folding, protein import into mitochondrial intermembrane space, protein refolding, protein stabilization, response to cold, response to unfolded protein; MF: ATP binding, ATP-dependent protein folding chaperone, apolipoprotein A-I binding, apolipoprotein binding, cysteine-type endopeptidase activator activity, double-stranded RNA binding, enzyme binding, high-density lipoprotein particle binding, isomerase activity, lipopolysaccharide binding, modification-dependent protein binding, nucleotide binding, p53 binding, protein-containing complex binding, protein-folding chaperone binding, ubiquitin protein ligase binding; CC: Golgi cisterna, cell surface, clathrin-coated pit, coated vesicle, cytoplasm, cytosol, early endosome, extracellular exosome, extracellular space, lipopolysaccharide receptor complex, membrane, migrasome, mitochondrial crista, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, myelin sheath, peroxisomal matrix, plasma membrane, protein-containing complex, secretory granule, sperm midpiece, sperm plasma membrane, zymogen granule
Pathways: Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial protein import, Protein localization, RNA degradation - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type I diabetes mellitus - Mus musculus (mouse)
UniProt: P63038
Entrez ID: 15510
|
Does Knockout of Ccr3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ccr3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ccr3 (C-C motif chemokine receptor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, G protein-coupled receptor signaling pathway, angioblast cell migration, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, eosinophil chemotaxis, immune response, inflammatory response, mast cell chemotaxis, positive regulation of angiogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of endothelial cell proliferation, signal transduction; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity, protein binding; CC: cytoplasm, endosome, external side of plasma membrane, extracellular space, membrane, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Human cytomegalovirus infection - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral carcinogenesis - Mus musculus (mouse), Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: P51678
Entrez ID: 12771
|
Does Knockout of Kdm8 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Kdm8
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Kdm8 (lysine (K)-specific demethylase 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G2/M transition of mitotic cell cycle, chromatin organization, chromatin remodeling, circadian regulation of gene expression, fibroblast proliferation, in utero embryonic development, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, protein destabilization, proteolysis, regulation of gene expression, regulation of signal transduction by p53 class mediator, rhythmic process; MF: aminopeptidase activity, chromatin binding, dioxygenase activity, endopeptidase activity, histone H3K36 demethylase activity, hydrolase activity, metal ion binding, oxidoreductase activity, p53 binding, peptidase activity, peptidyl-arginine 3-dioxygenase activity, protein binding; CC: chromosome, cytosol, nucleoplasm, nucleus
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Protein hydroxylation
UniProt: Q9CXT6
Entrez ID: 77035
|
Does Knockout of Nle1 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Nle1
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Nle1 (notchless homolog 1)
Type: protein-coding
Summary: Acts upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus. Is expressed in several structures, including 2-cell stage embryo; gonad; hemolymphoid system gland; inner cell mass; and liver. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Notch signaling pathway, hematopoietic stem cell homeostasis, inner cell mass cell differentiation, kidney development, negative regulation of mitotic cell cycle, positive regulation of canonical Wnt signaling pathway, regulation of Notch signaling pathway, ribosomal large subunit biogenesis, skeletal system morphogenesis, somitogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8VEJ4
Entrez ID: 217011
|
Does Knockout of Sqstm1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Sqstm1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sqstm1 (sequestosome 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aggrephagy, apoptotic process, autophagy, brown fat cell proliferation, cell differentiation, cellular response to stress, endosome organization, energy homeostasis, immune system process, macroautophagy, membraneless organelle assembly, mitophagy, negative regulation of ferroptosis, negative regulation of protein ubiquitination, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of transcription by RNA polymerase II, pexophagy, positive regulation of autophagy, positive regulation of long-term synaptic potentiation, positive regulation of protein localization to plasma membrane, protein K63-linked ubiquitination, protein catabolic process, protein import into nucleus, protein localization to perinuclear region of cytoplasm, protein targeting to vacuole involved in autophagy, regulation of canonical NF-kappaB signal transduction, regulation of protein complex stability, response to ischemia, response to mitochondrial depolarisation, temperature homeostasis, toll-like receptor 4 signaling pathway, ubiquitin-dependent protein catabolic process; MF: K63-linked polyubiquitin modification-dependent protein binding, SH2 domain binding, enzyme binding, identical protein binding, ionotropic glutamate receptor binding, metal ion binding, molecular condensate scaffold activity, molecular sequestering activity, protein binding, protein kinase C binding, protein kinase binding, protein sequestering activity, protein-containing complex binding, protein-macromolecule adaptor activity, signaling adaptor activity, signaling receptor activity, transcription coregulator activity, ubiquitin binding, ubiquitin protein ligase binding, ubiquitin-modified protein reader activity, zinc ion binding; CC: Lewy body, P-body, PML body, aggresome, amphisome, autolysosome, autophagosome, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endosome, glutamatergic synapse, inclusion body, intracellular membraneless organelle, late endosome, lysosome, mitochondrion, nucleus, phagophore assembly site, sarcomere, sperm midpiece, synapse
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy, Autophagy - animal - Mus musculus (mouse), Cell death signalling via NRAGE, NRIF and NADE, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Mus musculus (mouse), Cytokine Signaling in Immune system, Death Receptor Signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, KEAP1-NFE2L2 pathway, Macroautophagy, Mitophagy, Mitophagy - animal - Mus musculus (mouse), NF-kB is activated and signals survival, NRIF signals cell death from the nucleus, Necroptosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Pexophagy, Selective autophagy, Signal Transduction, Signaling by Interleukins, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB
UniProt: Q64337
Entrez ID: 18412
|
Does Knockout of Dnajc5g in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Dnajc5g
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dnajc5g (DnaJ heat shock protein family (Hsp40) member C5 gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, cytoplasm, membrane
Pathways: Protein processing in endoplasmic reticulum - Mus musculus (mouse)
UniProt: A0A087WQK2, Q8C632, A0A087WSK1
Entrez ID: 231098
|
Does Knockout of Lyve1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Lyve1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lyve1 (lymphatic vessel endothelial hyaluronan receptor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, glycosaminoglycan catabolic process, hyaluronan catabolic process, positive regulation of cellular extravasation, receptor-mediated endocytosis; MF: cargo receptor activity, hyaluronic acid binding, signaling receptor activity, transmembrane signaling receptor activity; CC: cell periphery, membrane, plasma membrane
Pathways: Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q8BHC0
Entrez ID: 114332
|
Does Knockout of Plekhb2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Plekhb2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Plekhb2 (pleckstrin homology domain containing, family B (evectins) member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endosome, membrane, recycling endosome membrane
Pathways:
UniProt: Q9QZC7
Entrez ID: 226971
|
Does Knockout of Atxn10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Atxn10
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Atxn10 (ataxin 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cilium assembly, nervous system development, neuron projection development, plasma membrane bounded cell projection organization, regulation of cytokinesis; MF: enzyme binding, identical protein binding, protein binding; CC: cell projection, centriole, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, dendrite, midbody, neuronal cell body, perinuclear region of cytoplasm, plasma membrane
Pathways: Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: P28658
Entrez ID: 54138
|
Does Knockout of Slc12a9 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Slc12a9
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Slc12a9 (solute carrier family 12 (potassium/chloride transporters), member 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell volume homeostasis, chloride ion homeostasis, chloride transmembrane transport, inorganic cation transmembrane transport, metal ion transport, monoatomic ion transport, potassium ion homeostasis, potassium ion transmembrane transport, transmembrane transport; MF: chloride:monoatomic cation symporter activity, metal ion transmembrane transporter activity, potassium:chloride symporter activity, transmembrane transporter activity; CC: lysosomal membrane, lysosome, membrane, plasma membrane
Pathways:
UniProt: Q99MR3
Entrez ID: 83704
|
Does Knockout of Rhbdf1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Rhbdf1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rhbdf1 (rhomboid 5 homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, cell population proliferation, negative regulation of protein secretion, regulation of epidermal growth factor receptor signaling pathway, regulation of proteasomal protein catabolic process, regulation of protein secretion; CC: Golgi apparatus, Golgi membrane, cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q6PIX5
Entrez ID: 13650
|
Does Knockout of Vmn2r121 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Vmn2r121
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Vmn2r121 (vomeronasal 2, receptor 121)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2W7Z9, A2BE32, A0A3B2WAV1
Entrez ID: 100038941
|
Does Knockout of Cdc42ep1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Cdc42ep1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cdc42ep1 (CDC42 effector protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, positive regulation of actin filament polymerization, positive regulation of pseudopodium assembly, regulation of cell shape; MF: protein binding, small GTPase binding; CC: cytoplasm, cytoskeleton, endomembrane system, membrane, plasma membrane
Pathways: RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q91W92
Entrez ID: 104445
|
Does Knockout of Ndufs5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ndufs5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ndufs5 (NADH:ubiquinone oxidoreductase core subunit S5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q99LY9
Entrez ID: 595136
|
Does Knockout of Morc2a in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Morc2a
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Morc2a (microrchidia 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, chromatin remodeling, constitutive heterochromatin formation, transposable element silencing by heterochromatin formation; MF: ATP binding, ATP hydrolysis activity, chromatin binding, histone binding, hydrolase activity, identical protein binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein homodimerization activity, zinc ion binding; CC: chromosome, cytoplasm, cytosol, heterochromatin, nuclear matrix, nucleoplasm, nucleus
Pathways: Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids
UniProt: Q69ZX6
Entrez ID: 74522
|
Does Knockout of Mettl15 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Mettl15
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mettl15 (methyltransferase like 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, rRNA base methylation; MF: methyltransferase activity, rRNA (cytosine-N4-)-methyltransferase activity, transferase activity; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q9DCL4
Entrez ID: 76894
|
Does Knockout of Zbtb7b in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Zbtb7b
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Zbtb7b (zinc finger and BTB domain containing 7B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NK T cell differentiation, adaptive thermogenesis, cell differentiation, lactation, negative regulation of CD8-positive, alpha-beta T cell differentiation, negative regulation of NK T cell proliferation, negative regulation of T-helper 17 cell differentiation, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive regulation of CD4-positive, alpha-beta T cell differentiation, positive regulation of SREBP signaling pathway, positive regulation of brown fat cell differentiation, positive regulation of cold-induced thermogenesis, positive regulation of fat cell differentiation, positive regulation of gene expression, positive regulation of insulin receptor signaling pathway, positive regulation of interleukin-17 production, positive regulation of transcription by RNA polymerase II, regulation of CD8-positive, alpha-beta T cell differentiation, regulation of T-helper cell differentiation, regulation of gene expression, regulation of transcription by RNA polymerase II, response to insulin; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, identical protein binding, metal ion binding, protein binding, protein homodimerization activity, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q64321
Entrez ID: 22724
|
Does Knockout of Dppa2 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Dppa2
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Dppa2 (developmental pluripotency associated 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epigenetic regulation of gene expression, lung-associated mesenchyme development, positive regulation of stem cell proliferation, stem cell population maintenance, system development; MF: chromatin binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q9CWH0
Entrez ID: 73703
|
Does Knockout of Slc51b in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,491
|
Knockout
|
Slc51b
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Slc51b (solute carrier family 51, beta subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid and bile salt transport, bile acid secretion, lipid transport, positive regulation of protein exit from endoplasmic reticulum, positive regulation of protein glycosylation, positive regulation of protein targeting to membrane, regulation of protein stability, transmembrane transport; MF: bile acid transmembrane transporter activity, protein binding, protein heterodimerization activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane, protein-containing complex
Pathways: Bile acid and bile salt metabolism, Bile secretion - Mus musculus (mouse), Metabolism, Metabolism of lipids, Metabolism of steroids, Recycling of bile acids and salts
UniProt: Q80WK2
Entrez ID: 330962
|
Does Knockout of Eaf1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Eaf1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Eaf1 (ELL associated factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II; MF: transcription elongation factor activity; CC: Cajal body, intercellular bridge, nuclear body, nuclear speck, nucleoplasm, nucleus, super elongation complex, transcription elongation factor complex
Pathways: Formation of RNA Pol II elongation complex , Gene expression (Transcription), RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q9D4C5
Entrez ID: 74427
|
Does Knockout of Dab2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Dab2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dab2 (disabled 2, mitogen-responsive phosphoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, cell differentiation, cell morphogenesis, cellular response to epidermal growth factor stimulus, cellular response to transforming growth factor beta stimulus, clathrin coat assembly, endocytosis, endoderm development, endodermal cell differentiation, establishment of localization in cell, hematopoietic stem cell proliferation, in utero embryonic development, leading edge cell differentiation, myeloid cell differentiation, negative regulation of ERK1 and ERK2 cascade, negative regulation of androgen receptor signaling pathway, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of epithelial cell proliferation, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of neuron projection development, negative regulation of protein localization to plasma membrane, negative regulation of transcription by RNA polymerase II, pinocytosis, positive regulation of JNK cascade, positive regulation of SMAD protein signal transduction, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of aldosterone biosynthetic process, positive regulation of aldosterone secretion, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of clathrin-dependent endocytosis, positive regulation of early endosome to late endosome transport, positive regulation of endocytosis, positive regulation of epithelial to mesenchymal transition, positive regulation of integrin-mediated signaling pathway, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of receptor internalization, positive regulation of receptor recycling, positive regulation of substrate adhesion-dependent cell spreading, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, protein transport, receptor-mediated endocytosis, renal protein absorption, response to steroid hormone, transforming growth factor beta receptor signaling pathway; MF: AP-2 adaptor complex binding, SMAD binding, cargo receptor activity, clathrin adaptor activity, clathrin binding, integrin binding, low-density lipoprotein particle receptor binding, phosphatidylinositol binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: apical plasma membrane, clathrin coat of coated pit, clathrin-coated pit, clathrin-coated vesicle, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, fibrillar center, intracellular membrane-bounded organelle, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Endocytosis - Mus musculus (mouse)
UniProt: P98078
Entrez ID: 13132
|
Does Knockout of Rab5a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Rab5a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rab5a (RAB5A, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amyloid-beta clearance by transcytosis, canonical Wnt signaling pathway, early endosome to late endosome transport, endocytosis, endosomal transport, host-mediated perturbation of viral process, intracellular protein transport, membrane fusion, phagocytosis, plasma membrane to endosome transport, positive regulation of exocytosis, protein localization to early endosome, protein transport, receptor internalization, regulation of endosome size, regulation of filopodium assembly, regulation of long-term neuronal synaptic plasticity, regulation of synaptic vesicle exocytosis, synaptic vesicle recycling; MF: G protein activity, GDP binding, GDP-dissociation inhibitor binding, GTP binding, GTPase activity, guanyl nucleotide binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: actin cytoskeleton, axon, axon terminus, cell projection, cytoplasm, cytoplasmic side of early endosome membrane, cytoplasmic vesicle, cytosol, dendrite, early endosome, early endosome membrane, early phagosome, endocytic vesicle, endomembrane system, endosome, endosome membrane, glutamatergic synapse, melanosome, membrane, membrane raft, neuronal cell body, nucleoplasm, perinuclear region of cytoplasm, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, postsynaptic endocytic zone membrane, presynaptic endosome, protein-containing complex, recycling endosome, ruffle, somatodendritic compartment, synaptic vesicle, synaptic vesicle membrane, terminal bouton, zymogen granule membrane
Pathways: Amoebiasis - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Clathrin-mediated endocytosis, Endocytosis - Mus musculus (mouse), Factors involved in megakaryocyte development and platelet production, Hemostasis, Membrane Trafficking, Metabolism, Metabolism of lipids, Metabolism of proteins, PI Metabolism, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Phospholipid metabolism, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Ras signaling pathway - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Synthesis of PIPs at the plasma membrane, Tuberculosis - Mus musculus (mouse), Vasopressin-regulated water reabsorption - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q9CQD1
Entrez ID: 271457
|
Does Knockout of Trim60 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Trim60
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Trim60 (tripartite motif-containing 60)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: canonical NF-kappaB signal transduction, innate immune response, negative regulation of non-canonical NF-kappaB signal transduction, non-canonical NF-kappaB signal transduction, protein K63-linked ubiquitination, regulation of gene expression; MF: SUMO-ubiquitin ligase activity, metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: Q8VI40
Entrez ID: 234329
|
Does Knockout of Dars2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Dars2
|
response to virus
|
Microglial Cell Line
|
Gene: Dars2 (aspartyl-tRNA synthetase 2 (mitochondrial))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aspartyl-tRNA aminoacylation, mitochondrial asparaginyl-tRNA aminoacylation, tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, aspartate-tRNA ligase activity, aspartate-tRNA(Asn) ligase activity, ligase activity, nucleic acid binding, nucleotide binding, protein homodimerization activity; CC: cytoplasm, membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8BIP0
Entrez ID: 226539
|
Does Knockout of Fgf15 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Fgf15
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Fgf15 (fibroblast growth factor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fibroblast growth factor receptor signaling pathway, heart development, negative regulation of bile acid biosynthetic process, negative regulation of gene expression, neural crest cell migration, neurogenesis, positive regulation of D-glucose import, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of cell population proliferation, regulation of cell migration, response to bacterium, response to ethanol; MF: fibroblast growth factor receptor binding, growth factor activity, protein binding; CC: cytoplasm, extracellular region, extracellular space
Pathways: Breast cancer - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Downstream signaling of activated FGFR4, FGFR4 ligand binding and activation, FRS-mediated FGFR4 signaling, Gastric cancer - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK1/MAPK3 signaling, Melanoma - Mus musculus (mouse), Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway - Mus musculus (mouse), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Mus musculus (mouse), Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of actin cytoskeleton - Mus musculus (mouse), SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), betaKlotho-mediated ligand binding
UniProt: O35622
Entrez ID: 14170
|
Does Knockout of Taf12 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Taf12
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Taf12 (TATA-box binding protein associated factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II preinitiation complex assembly, mRNA transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, protein binding, protein heterodimerization activity, transcription coactivator activity; CC: SAGA complex, nucleus, transcription factor TFIID complex, transcription factor TFTC complex
Pathways: Basal transcription factors - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q8VE65
Entrez ID: 66464
|
Does Knockout of Adgre5 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Adgre5
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Adgre5 (adhesion G protein-coupled receptor E5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cell adhesion, cell surface receptor signaling pathway, positive regulation of synapse assembly, signal transduction; MF: G protein-coupled receptor activity, calcium ion binding, chondroitin sulfate binding, transmembrane signaling receptor activity; CC: external side of plasma membrane, extracellular region, leading edge membrane, membrane, plasma membrane
Pathways: Class B/2 (Secretin family receptors), GPCR ligand binding, Immune System, Innate Immune System, Neutrophil degranulation, Signal Transduction, Signaling by GPCR
UniProt: Q9Z0M6
Entrez ID: 26364
|
Does Knockout of Irf8 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Irf8
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Irf8 (interferon regulatory factor 8)
Type: protein-coding
Summary: The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: autophagy, cellular response to lipopolysaccharide, cellular response to type II interferon, defense response to bacterium, defense response to protozoan, dendritic cell differentiation, follicular B cell differentiation, germinal center B cell differentiation, immune response, immune system process, lymphocyte activation involved in immune response, lymphocyte differentiation, myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, phagocytosis, plasmacytoid dendritic cell differentiation, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of interleukin-12 production, positive regulation of transcription by RNA polymerase II, positive regulation of type II interferon production, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, regulation of type I interferon production, response to bacterium; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Pertussis - Mus musculus (mouse)
UniProt: P23611
Entrez ID: 15900
|
Does Knockout of Mau2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Mau2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mau2 (MAU2 sister chromatid cohesion factor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, chromosome segregation, maintenance of mitotic sister chromatid cohesion, mitotic sister chromatid cohesion; CC: SMC loading complex, Scc2-Scc4 cohesin loading complex, chromatin, chromosome, nuclear body, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cohesin Loading onto Chromatin, M Phase, Mitotic Telophase/Cytokinesis
UniProt: Q9D2X5
Entrez ID: 74549
|
Does Knockout of Map3k14 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,273
|
Knockout
|
Map3k14
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Map3k14 (mitogen-activated protein kinase kinase kinase 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, cellular response to mechanical stimulus, defense response to virus, immune response, non-canonical NF-kappaB signal transduction; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, fibrillar center, nucleoplasm
Pathways: Adaptive Immune System, Alcoholic liver disease - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), C-type lectin receptors (CLRs), CD28 dependent PI3K/Akt signaling, CLEC7A (Dectin-1) signaling, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Co-stimulation by CD28, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Epstein-Barr virus infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Innate Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), NF-kappa B signaling pathway - Mus musculus (mouse), NIK-->noncanonical NF-kB signaling, Osteoclast differentiation - Mus musculus (mouse), Regulation of T cell activation by CD28 family, T cell receptor signaling pathway - Mus musculus (mouse), TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling pathway - Mus musculus (mouse), TNFR2 non-canonical NF-kB pathway
UniProt: Q9WUL6
Entrez ID: 53859
|
Does Knockout of Nfe2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Nfe2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nfe2 (nuclear factor, erythroid derived 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell signaling, gene expression, labyrinthine layer blood vessel development, negative regulation of bone mineralization, negative regulation of cell population proliferation, negative regulation of syncytium formation by plasma membrane fusion, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, WW domain binding, identical protein binding, protein binding, sequence-specific double-stranded DNA binding; CC: PML body, RNA polymerase II transcription regulator complex, cytoplasm, nucleoplasm, nucleus, protein-DNA complex
Pathways: Factors involved in megakaryocyte development and platelet production, Hemostasis
UniProt: Q07279
Entrez ID: 18022
|
Does Knockout of Scgb1b27 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Scgb1b27
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Scgb1b27 (secretoglobin, family 1B, member 27)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: steroid binding; CC: cytoplasm, extracellular region
Pathways:
UniProt: G3UXN8, Q91WB5
Entrez ID: 11354
|
Does Knockout of Atp2b1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Atp2b1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Atp2b1 (ATPase, Ca++ transporting, plasma membrane 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion export, calcium ion export across plasma membrane, calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, monoatomic ion transport, negative regulation of cytokine production, negative regulation of cytosolic calcium ion concentration, positive regulation of bone mineralization, positive regulation of calcium ion transport, regulation of blood pressure, regulation of cellular response to insulin stimulus, regulation of cytosolic calcium ion concentration, regulation of vascular associated smooth muscle contraction; MF: ATP binding, ATP hydrolysis activity, P-type calcium transporter activity, PDZ domain binding, calcium ion transmembrane transporter activity, calmodulin binding, metal ion binding, molecular function inhibitor activity, nucleotide binding, protein binding; CC: GABA-ergic synapse, apical part of cell, apical plasma membrane, basolateral plasma membrane, cell projection, cytoplasmic side of plasma membrane, cytoplasmic vesicle, dendrite membrane, dendritic spine membrane, glutamatergic synapse, immunological synapse, intracellular membrane-bounded organelle, membrane, neuronal cell body membrane, nucleoplasm, photoreceptor ribbon synapse, plasma membrane, presynaptic active zone membrane, presynaptic membrane, synapse, synaptic vesicle membrane
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cardiac conduction, Endocrine and other factor-regulated calcium reabsorption - Mus musculus (mouse), Hemostasis, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Mineral absorption - Mus musculus (mouse), Muscle contraction, Pancreatic secretion - Mus musculus (mouse), Platelet calcium homeostasis, Platelet homeostasis, Reduction of cytosolic Ca++ levels, Salivary secretion - Mus musculus (mouse), Transport of small molecules, cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: G5E829
Entrez ID: 67972
|
Does Knockout of Psmg4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Psmg4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Psmg4 (proteasome (prosome, macropain) assembly chaperone 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, proteasome assembly; MF: molecular_function, protein binding, protein-containing complex binding; CC: cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Proteasome assembly
UniProt: P0C7N9
Entrez ID: 69666
|
Does Knockout of Cuedc2 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Cuedc2
|
cell proliferation
|
Regulatory T cell
|
Gene: Cuedc2 (CUE domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cytokine production involved in inflammatory response, negative regulation of macrophage cytokine production; MF: molecular_function, ubiquitin binding; CC: cytoplasm, cytosol, nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q9CXX9
Entrez ID: 67116
|
Does Knockout of Dip2a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Dip2a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dip2a (disco interacting protein 2 homolog A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acetyl-CoA biosynthetic process, dendritic spine morphogenesis, negative regulation of gene expression, nervous system development, positive regulation of peptidyl-lysine acetylation, regulation of modification of postsynaptic actin cytoskeleton; MF: acetate-CoA ligase activity, ligase activity, protein binding; CC: cell projection, cell surface, dendritic spine, glutamatergic synapse, membrane, mitochondrion, plasma membrane, postsynapse, synapse
Pathways:
UniProt: Q8BWT5
Entrez ID: 64451
|
Does Knockout of Chchd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Chchd1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Chchd1 (coiled-coil-helix-coiled-coil-helix domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in mitochondrial translation. Located in mitochondrion. Orthologous to human CHCHD1 (coiled-coil-helix-coiled-coil-helix domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation; CC: cytosol, fibrillar center, mitochondrial inner membrane, mitochondrial ribosome, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q9CQA6
Entrez ID: 66121
|
Does Knockout of Ddx52 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Ddx52
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ddx52 (DExD box helicase 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8K301
Entrez ID: 78394
|
Does Knockout of Tgif1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Tgif1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tgif1 (TGFB-induced factor homeobox 1)
Type: protein-coding
Summary: Enables chromatin binding activity. Acts upstream of or within several processes, including negative regulation of retinoic acid receptor signaling pathway; positive regulation of amacrine cell differentiation; and regionalization. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo ectoderm; and genitourinary system. Used to study otitis media. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 4. Orthologous to human TGIF1 (TGFB induced factor homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: amacrine cell differentiation, cellular response to growth factor stimulus, determination of left/right symmetry, dorsal/ventral pattern formation, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of retinoic acid receptor signaling pathway, negative regulation of transcription by RNA polymerase II, neural tube closure, nodal signaling pathway, positive regulation of amacrine cell differentiation, positive regulation of fibroblast proliferation, regulation of DNA-templated transcription, regulation of gastrulation, response to xenobiotic stimulus, retina development in camera-type eye; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, JUN kinase binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, co-SMAD binding, protein binding, sequence-specific double-stranded DNA binding; CC: nucleoplasm, nucleus
Pathways: Downregulation of SMAD2/3:SMAD4 transcriptional activity, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta signaling pathway - Mus musculus (mouse), Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: P70284
Entrez ID: 21815
|
Does Knockout of Fhod3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Fhod3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fhod3 (formin homology 2 domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament network formation, actin filament organization, cardiac myofibril assembly, negative regulation of actin filament polymerization, positive regulation of stress fiber assembly, sarcomere organization; MF: actin binding, actin filament binding; CC: Z disc, cytoplasm, cytoskeleton, sarcomere, striated muscle thin filament
Pathways:
UniProt: Q76LL6
Entrez ID: 225288
|
Does Knockout of Scube1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Scube1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Scube1 (signal peptide, CUB domain, EGF-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of smoothened signaling pathway, signal transduction; MF: calcium ion binding, identical protein binding, protein binding; CC: cell surface, external side of plasma membrane, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization
UniProt: Q6NZL8
Entrez ID: 64706
|
Does Knockout of Cela3a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Cela3a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cela3a (chymotrypsin-like elastase family, member 3A)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to several human genes including CELA3B (chymotrypsin like elastase 3B). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Pathways: Pancreatic secretion - Mus musculus (mouse), Protein digestion and absorption - Mus musculus (mouse)
UniProt: A2A9U8
Entrez ID: 242711
|
Does Knockout of Cd14 in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,043
|
Knockout
|
Cd14
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: Cd14 (CD14 antigen)
Type: protein-coding
Summary: This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: cell surface pattern recognition receptor signaling pathway, cellular response to diacyl bacterial lipopeptide, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to molecule of bacterial origin, cellular response to triacyl bacterial lipopeptide, immune system process, inflammatory response, innate immune response, lipopolysaccharide-mediated signaling pathway, positive regulation of cytokine production, positive regulation of endocytosis, positive regulation of interleukin-8 production, positive regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, positive regulation of type II interferon production, receptor-mediated endocytosis, response to bacterium, response to electrical stimulus, response to ethanol, response to lipopolysaccharide, response to magnesium ion, response to molecule of bacterial origin, response to tumor necrosis factor, toll-like receptor 4 signaling pathway; MF: lipopolysaccharide binding, lipopolysaccharide immune receptor activity, lipoteichoic acid binding, molecular carrier activity; CC: Golgi apparatus, cell surface, external side of plasma membrane, extracellular region, extracellular space, lipopolysaccharide receptor complex, membrane, membrane raft, plasma membrane, side of membrane
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Acute myeloid leukemia - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Apoptosis, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Hematopoietic cell lineage - Mus musculus (mouse), IKK complex recruitment mediated by RIP1, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Innate Immune System, Legionellosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , NF-kappa B signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Pertussis - Mus musculus (mouse), Phagosome - Mus musculus (mouse), Programmed Cell Death, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TLR by endogenous ligand, Salmonella infection - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , TRIF-mediated programmed cell death, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse), Transfer of LPS from LBP carrier to CD14, Tuberculosis - Mus musculus (mouse)
UniProt: P10810
Entrez ID: 12475
|
Does Knockout of Ubap2 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ubap2
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ubap2 (ubiquitin-associated protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: chromosome, cytoplasm, nucleus
Pathways:
UniProt: Q91VX2
Entrez ID: 68926
|
Does Knockout of Faap20 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,535
|
Knockout
|
Faap20
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Faap20 (Fanconi anemia core complex associated protein 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, interstrand cross-link repair, translesion synthesis; MF: K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, polyubiquitin modification-dependent protein binding, ubiquitin binding, ubiquitin-modified protein reader activity, zinc ion binding; CC: Fanconi anaemia nuclear complex, cell junction, chromatin, chromosome, nuclear body, nucleoplasm, nucleus
Pathways: Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, DNA Repair, Fanconi Anemia Pathway, Immune System, Interferon Signaling, PKR-mediated signaling
UniProt: Q3UN58
Entrez ID: 67513
|
Does Knockout of Rps5 in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Rps5
|
response to virus
|
Microglial Cell Line
|
Gene: Rps5 (ribosomal protein S5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, regulation of translational fidelity, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, mRNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P97461
Entrez ID: 20103
|
Does Knockout of Rnft1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Rnft1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Rnft1 (ring finger protein, transmembrane 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of ERAD pathway, protein autoubiquitination, protein ubiquitination; MF: metal ion binding, transferase activity, ubiquitin binding, ubiquitin protein ligase activity, zinc ion binding; CC: early endosome membrane, endoplasmic reticulum, endosome, membrane
Pathways:
UniProt: Q9DCN7
Entrez ID: 76892
|
Does Knockout of Nefh in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Nefh
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nefh (neurofilament, heavy polypeptide)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, axon regeneration, axonogenesis, cellular response to leukemia inhibitory factor, intermediate filament bundle assembly, intermediate filament cytoskeleton organization, microtubule cytoskeleton organization, neurofilament bundle assembly, neurofilament cytoskeleton organization, ovarian follicle atresia, peripheral nervous system neuron axonogenesis, postsynaptic intermediate filament cytoskeleton organization, postsynaptic modulation of chemical synaptic transmission, regulation of organelle transport along microtubule, response to sodium arsenite; MF: protein kinase binding, protein-containing complex binding, protein-macromolecule adaptor activity, structural constituent of cytoskeleton, structural constituent of postsynaptic intermediate filament cytoskeleton, toxic substance binding; CC: Schaffer collateral - CA1 synapse, apical dendrite, axon, basal proximal dendrite, cell projection, cytoplasm, cytoskeleton, intermediate filament, mitochondrion, myelin sheath, neurofibrillary tangle, neurofilament, neuronal cell body, perikaryon, postsynaptic density, postsynaptic intermediate filament cytoskeleton
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: P19246
Entrez ID: 380684
|
Does Knockout of 4921524L21Rik in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
4921524L21Rik
|
protein/peptide accumulation
|
Mouse cell
|
Gene: 4921524L21Rik (RIKEN cDNA 4921524L21 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A3Q4EGB9, Q9D5T2, A0A3Q4EGN5
Entrez ID: 70901
|
Does Knockout of Tbc1d13 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Tbc1d13
|
cell cycle progression
|
breast epithelium
|
Gene: Tbc1d13 (TBC1 domain family, member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular protein transport; MF: GTPase activator activity, protein binding, small GTPase binding; CC: cytoplasm, cytosol, membrane
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q8R3D1
Entrez ID: 70296
|
Does Knockout of Ndufa1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Ndufa1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Ndufa1 (NADH:ubiquinone oxidoreductase subunit A1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: O35683
Entrez ID: 54405
|
Does Knockout of Ankfy1 in macrophage causally result in phagocytosis?
| 1
| 1,888
|
Knockout
|
Ankfy1
|
phagocytosis
|
macrophage
|
Gene: Ankfy1 (ankyrin repeat and FYVE domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to lysosome transport, endocytosis, endosomal transport, endosomal vesicle fusion, positive regulation of pinocytosis, retrograde transport, endosome to Golgi; MF: metal ion binding, phosphatidylinositol phosphate binding, small GTPase binding, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, cytosol, early endosome, endosome, endosome membrane, macropinosome, membrane, retromer complex
Pathways: RHO GTPase cycle, RHOD GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q810B6
Entrez ID: 11736
|
Does Knockout of Spink14 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Spink14
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Spink14 (serine peptidase inhibitor, Kazal type 14)
Type: protein-coding
Summary: Orthologous to human SPINK14 (serine peptidase inhibitor Kazal type 14 (putative)). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cellular_component, extracellular region
Pathways:
UniProt: B9EJP9
Entrez ID: 433178
|
Does Activation of Ankrd23 in Mouse cell causally result in protein/peptide accumulation?
| 1
| 690
|
Activation
|
Ankrd23
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ankrd23 (ankyrin repeat domain 23)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid metabolic process, positive regulation of transcription by RNA polymerase II, regulation of sarcomere organization, response to mechanical stimulus, response to muscle stretch; MF: titin binding, transcription cis-regulatory region binding; CC: I band, actin cytoskeleton, cytosol, intercalated disc, myofibril, nucleoplasm, nucleus
Pathways:
UniProt: Q812A3
Entrez ID: 78321
|
Does Knockout of Nfat5 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Nfat5
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Nfat5 (nuclear factor of activated T cells 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA-templated transcription, R-loop processing, calcineurin-NFAT signaling cascade, cellular response to cytokine stimulus, negative regulation of urine volume, positive regulation of canonical NF-kappaB signal transduction, positive regulation of gene expression, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of calcineurin-NFAT signaling cascade, regulation of intracellular signal transduction, renal water homeostasis, response to stress, response to water deprivation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, sequence-specific double-stranded DNA binding; CC: chromosome, cytoplasm, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q9WV30
Entrez ID: 54446
|
Does Knockout of Fnta in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Fnta
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Fnta (farnesyltransferase, CAAX box, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: enzyme-linked receptor protein signaling pathway, negative regulation of apoptotic process, nuclear envelope organization, peptide pheromone maturation, positive regulation of Rac protein signal transduction, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of skeletal muscle acetylcholine-gated channel clustering, protein farnesylation, protein geranylgeranylation, protein maturation, regulation of microtubule-based movement; MF: CAAX-protein geranylgeranyltransferase activity, Rab geranylgeranyltransferase activity, acetyltransferase activator activity, alpha-tubulin binding, enzyme binding, heterocyclic compound binding, microtubule binding, molecular adaptor activity, peptide binding, prenyltransferase activity, protein farnesyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, receptor tyrosine kinase binding, small molecule binding, transferase activity, zinc ion binding; CC: CAAX-protein geranylgeranyltransferase complex, cytoplasm, microtubule associated complex, protein farnesyltransferase complex
Pathways: Terpenoid backbone biosynthesis - Mus musculus (mouse)
UniProt: Q61239
Entrez ID: 14272
|
Does Knockout of Nek5 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Nek5
|
cell cycle progression
|
breast epithelium
|
Gene: Nek5 (NIMA (never in mitosis gene a)-related expressed kinase 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, cellular_component, cilium, motile cilium, sperm flagellum
Pathways:
UniProt: Q7TSC3
Entrez ID: 330721
|
Does Knockout of Rce1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Rce1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rce1 (Ras converting CAAX endopeptidase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CAAX-box protein maturation, CAAX-box protein processing, proteolysis; MF: endopeptidase activity, exopeptidase activity, hydrolase activity, metalloendopeptidase activity, peptidase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Deubiquitination, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Metabolism of proteins, Post-translational protein modification, RAF/MAP kinase cascade, RAS processing, Signal Transduction, Terpenoid backbone biosynthesis - Mus musculus (mouse), Ub-specific processing proteases
UniProt: P57791
Entrez ID: 19671
|
Does Knockout of Suds3 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Suds3
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Suds3 (suppressor of defective silencing 3 homolog (S. cerevisiae))
Type: protein-coding
Summary: Enables histone deacetylase binding activity and identical protein binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within blastocyst hatching. Part of Sin3-type complex. Is expressed in early conceptus; ovary; secondary oocyte; and seminiferous cord. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: apoptotic process, blastocyst hatching, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of stem cell population maintenance, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of stem cell population maintenance, regulation of gene expression; MF: enzyme binding, histone deacetylase activity, histone deacetylase binding, identical protein binding, protein binding; CC: Sin3-type complex, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Deubiquitination, HDACs deacetylate histones, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8BR65
Entrez ID: 71954
|
Does Knockout of Cib4 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Cib4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cib4 (calcium and integrin binding family member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, magnesium ion binding, metal ion binding, molecular_function
Pathways:
UniProt: Q9D9N5
Entrez ID: 73259
|
Does Knockout of Elof1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Elof1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Elof1 (ELF1 homolog, elongation factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, transcription elongation by RNA polymerase II, transcription-coupled nucleotide-excision repair; MF: RNA polymerase II complex binding, protein-macromolecule adaptor activity; CC: chromosome, nucleus, transcription elongation factor complex
Pathways:
UniProt: P60003
Entrez ID: 66126
|
Does Knockout of Mdn1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Mdn1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Mdn1 (midasin AAA ATPase 1)
Type: protein-coding
Summary: Predicted to be involved in ribosomal large subunit assembly and ribosomal large subunit export from nucleus. Predicted to be located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleus. Orthologous to human MDN1 (midasin AAA ATPase 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: ribosomal large subunit assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, molecular_function, nucleotide binding; CC: cytosol, intermediate filament cytoskeleton, nucleolus, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: A2ANY6, J3QMC5
Entrez ID: 100019
|
Does Knockout of Rhot2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Rhot2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Rhot2 (ras homolog family member T2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular homeostasis, establishment of mitochondrion localization, microtubule-mediated, mitochondrial outer membrane permeabilization, mitochondrion organization, mitochondrion transport along microtubule; MF: ATP hydrolysis activity, GDP binding, GTP binding, GTPase activity, calcium ion binding, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrial outer membrane, mitochondrion
Pathways: Miro GTPase Cycle, Mitophagy - animal - Mus musculus (mouse), RHOT2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8JZN7
Entrez ID: 214952
|
Does Knockout of Plekho1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Plekho1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Plekho1 (pleckstrin homology domain containing, family O member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lamellipodium morphogenesis, myoblast fusion, myoblast migration, regulation of cell shape, regulation of myoblast fusion; CC: cytoplasm, membrane, muscle cell projection membrane, nucleus, plasma membrane, ruffle membrane
Pathways:
UniProt: Q9JIY0
Entrez ID: 67220
|
Does Knockout of Sik2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Sik2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Sik2 (salt inducible kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERAD pathway, insulin receptor signaling pathway, intracellular signal transduction, lipid biosynthetic process, negative regulation of carbohydrate metabolic process, negative regulation of glycolytic process, negative regulation of lipid biosynthetic process, negative regulation of small molecule metabolic process, negative regulation of transcription from RNA polymerase II promoter by glucose, positive regulation of glycolytic process, positive regulation of transcription from RNA polymerase II promoter by glucose, protein autophosphorylation, protein phosphorylation, regulation of insulin receptor signaling pathway; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, endoplasmic reticulum membrane, nucleus
Pathways: Glucagon signaling pathway - Mus musculus (mouse)
UniProt: Q8CFH6
Entrez ID: 235344
|
Does Knockout of Ptpn11 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,157
|
Knockout
|
Ptpn11
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ptpn11 (protein tyrosine phosphatase, non-receptor type 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Bergmann glial cell differentiation, DNA damage checkpoint signaling, ERBB signaling pathway, atrioventricular canal development, axonogenesis, brain development, cellular response to epidermal growth factor stimulus, cellular response to mechanical stimulus, cerebellar cortex formation, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway, face morphogenesis, fibroblast growth factor receptor signaling pathway, genitalia development, glucose homeostasis, heart development, homeostasis of number of cells within a tissue, hormone metabolic process, hormone-mediated signaling pathway, inner ear development, integrin-mediated signaling pathway, intestinal epithelial cell migration, lipid metabolic process, megakaryocyte development, microvillus organization, multicellular organism growth, negative regulation of T cell proliferation, negative regulation of cell adhesion mediated by integrin, negative regulation of chondrocyte differentiation, negative regulation of cortisol secretion, negative regulation of growth hormone secretion, negative regulation of hormone secretion, negative regulation of insulin secretion, negative regulation of neutrophil activation, negative regulation of type I interferon production, neurotrophin TRK receptor signaling pathway, organ growth, peptidyl-tyrosine dephosphorylation, platelet formation, platelet-derived growth factor receptor signaling pathway, positive regulation of D-glucose import, positive regulation of ERK1 and ERK2 cascade, positive regulation of focal adhesion assembly, positive regulation of hormone secretion, positive regulation of insulin receptor signaling pathway, positive regulation of interferon-beta production, positive regulation of intracellular signal transduction, positive regulation of lipopolysaccharide-mediated signaling pathway, positive regulation of mitotic cell cycle, positive regulation of ossification, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of signal transduction, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, regulation of MAPK cascade, regulation of cell adhesion mediated by integrin, regulation of lipopolysaccharide-mediated signaling pathway, regulation of protein export from nucleus, regulation of protein-containing complex assembly, regulation of tumor necrosis factor production, triglyceride metabolic process, vasodilation; MF: D1 dopamine receptor binding, cadherin binding, cell adhesion molecule binding, hydrolase activity, insulin receptor binding, insulin receptor substrate binding, molecular adaptor activity, non-membrane spanning protein tyrosine phosphatase activity, peptide hormone receptor binding, phospholipase binding, phosphoprotein phosphatase activity, phosphotyrosine residue binding, protein binding, protein domain specific binding, protein kinase binding, protein tyrosine kinase binding, protein tyrosine phosphatase activity, receptor tyrosine kinase binding, signaling receptor complex adaptor activity; CC: cytoplasm, cytosol, nucleus, plasma membrane raft, protein-containing complex
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Adaptive Immune System, Adipocytokine signaling pathway - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Cell surface interactions at the vascular wall, Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Co-inhibition by BTLA, Co-inhibition by CTLA4, Co-inhibition by PD-1, Cytokine Signaling in Immune system, Developmental Biology, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, GAB1 signalosome, GPVI-mediated activation cascade, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Herpes simplex virus 1 infection - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Innate Immune System, Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Interferon Signaling, Interferon alpha/beta signaling, Interleukin-20 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-6 family signaling, Interleukin-6 signaling, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, MET activates PTPN11, MyD88-independent TLR4 cascade , Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PECAM1 interactions, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phospholipase D signaling pathway - Mus musculus (mouse), Platelet activation, signaling and aggregation, Platelet homeostasis, Platelet sensitization by LDL, Proteoglycans in cancer - Mus musculus (mouse), RAF-independent MAPK1/3 activation, RET signaling, RNA Polymerase II Transcription, Ras signaling pathway - Mus musculus (mouse), Regulation of IFNA/IFNB signaling, Regulation of RUNX1 Expression and Activity, Regulation of T cell activation by CD28 family, Renal cell carcinoma - Mus musculus (mouse), Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by MET, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Spry regulation of FGF signaling, TRIF (TICAM1)-mediated TLR4 signaling , Tie2 Signaling, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades, Transcriptional regulation by RUNX1
UniProt: P35235
Entrez ID: 19247
|
Does Knockout of Maz in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 165
|
Knockout
|
Maz
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Maz (MYC-associated zinc finger protein (purine-binding transcription factor))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, termination of RNA polymerase II transcription, transcription initiation at RNA polymerase II promoter; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways:
UniProt: A0A0U1RNL1, A0A0U1RNL9, F8VPK3, A0A0U1RQ66, A0A0U1RPH5
Entrez ID: 17188
|
Does Knockout of Fcf1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Fcf1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Fcf1 (FCF1 rRNA processing protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CTH6
Entrez ID: 73736
|
Does Knockout of Edil3 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Edil3
|
cell cycle progression
|
breast epithelium
|
Gene: Edil3 (EGF-like repeats and discoidin I-like domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, positive regulation of cell-substrate adhesion; MF: calcium ion binding, metal ion binding; CC: extracellular region, extracellular space
Pathways:
UniProt: O35474
Entrez ID: 13612
|
Does Knockout of Slc35f3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 83
|
Knockout
|
Slc35f3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Slc35f3 (solute carrier family 35, member F3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: thiamine transport; CC: cellular_component, membrane
Pathways:
UniProt: Q1LZI2
Entrez ID: 210027
|
Does Knockout of Lrriq1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Lrriq1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Lrriq1 (leucine-rich repeats and IQ motif containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, biological_process, ectopic germ cell programmed cell death, gene expression, single fertilization
Pathways:
UniProt: Q0P5X1
Entrez ID: 74978
|
Does Knockout of Pdcd2l in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Pdcd2l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pdcd2l (programmed cell death 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, biological_process
Pathways:
UniProt: Q8C5N5
Entrez ID: 68079
|
Does Knockout of Atxn2l in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Atxn2l
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Atxn2l (ataxin 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA metabolic process, stress granule assembly; MF: RNA binding, mRNA binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, membrane, nuclear speck, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse)
UniProt: Q7TQH0
Entrez ID: 233871
|
Does Knockout of Aagab in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Aagab
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Aagab (alpha- and gamma-adaptin binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, protein transport; CC: cytoplasm, cytosol, nuclear speck
Pathways:
UniProt: Q8R2R3
Entrez ID: 66939
|
Does Knockout of Nox1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Nox1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nox1 (NADPH oxidase 1)
Type: protein-coding
Summary: This gene encodes a subunit of the NADPH oxidase enzyme, which is a membrane-bound, multisubunit protein. This complex catalyzes the transfer of electrons from NADPH to molecular oxygen to produce superoxide or hydrogen peroxide and may have a role in antimicrobial killing and cell signaling. This protein binds other subunits in order to produce superoxide. In mouse, deficiency of this enzyme may be associated with changes in blood pressure. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: angiogenesis, cell chemotaxis, cell migration, cellular response to hyperoxia, defense response, extracellular matrix organization, glutathione metabolic process, hydrogen peroxide metabolic process, negative regulation of neuron maturation, oxygen metabolic process, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of inclusion body assembly, positive regulation of integrin biosynthetic process, positive regulation of neuron apoptotic process, positive regulation of neuron projection development, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of reactive oxygen species metabolic process, positive regulation of smooth muscle cell proliferation, positive regulation of superoxide anion generation, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, positive regulation of vascular endothelial growth factor production, regulation of systemic arterial blood pressure by renin-angiotensin, response to reactive oxygen species, superoxide anion generation, superoxide metabolic process; MF: NAD(P)H oxidase H2O2-forming activity, metal ion binding, oxidoreductase activity, small GTPase binding, superoxide-generating NAD(P)H oxidase activity, superoxide-generating NADPH oxidase activity; CC: NADPH oxidase complex, anchoring junction, cell projection, cytoplasm, early endosome, endosome, membrane, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate NADPH Oxidases, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8CIZ9
Entrez ID: 237038
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Does Knockout of Cachd1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
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| 165
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Knockout
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Cachd1
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regulation of signal transduction phenotype
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Embryonic Fibroblast Cell Line
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Gene: Cachd1 (cache domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transport; CC: membrane, voltage-gated calcium channel complex
Pathways:
UniProt: Q6PDJ1
Entrez ID: 320508
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