Datasets:
Lollitor
/
LogDataset

Dataset card Data Studio Files
xet
 Community
1
-logKd/Ki
float64
0.4
15.2
inputs
stringlengths
181
9.73k
11
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V K M I G G I G G F I V L T P V N I I G R N R L L D T G A D D T V I G G I G G L T P V N I I G R N </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( C O ) c c 1
11.02
G S E Q E S V K E F L A K A K E D F L K K W E S P A Q N T A H L D Q F E R I K T L G T G S F G R V M L V K H K E T G N H Y A M K I L D K Q K V V K L K Q I E H T L N E K R I L Q A V N F P F L V K L E F S F K D N S N L Y M V M E Y V P G G E M F S H L R R I G R F S E P H A R F Y A A Q I V L T F E Y L H S L D L I Y R D L K P E N L L I D Q Q G Y I Q V T D F G F A K R V K G R T W L C G T P E Y L A P E I I L S K G Y N K A V D W W A L G V L I Y E M A A G Y P P F F A D Q P I Q I Y E K I V S G K V R F P S H F S S D L K D L L R N L L Q V D L T K R F G N L K N G V N D I K N H K W F A T T D W I A I Y Q R K V E A P F I P K F K G P G D T S N F D D Y E E E E I R V I N E K C G K E F S E F </s> T L G T G S F G R V M L V Y A M K I L D K V L Q T E L V K M V M E Y V P G G E M F S L R D L K P E N L L I Q V T D G F G T P E Y V L E G Y P F D Q P I N F D Y E </s> C [ C @ @ H ] ( N C ( = O ) C C C C C C C C ( = O ) N 1 C C N ( c 2 n c n c 3 [ n H ] c c c 2 3 ) C C 1 ) C ( = O ) N [ C @ H ] ( C C C N C ( N ) = [ N H 2 + ] ) C ( = O ) N [ C @ H ] ( C C C N C ( N ) = [ N H 2 + ] ) C ( = O ) N [ C @ H ] ( C C C N C ( N ) = [ N H 2 + ] ) C ( = O ) N [ C @ H ] ( C C C N C ( N ) = [ N H 2 + ] ) C ( = O ) [ O - ]
11.05
M H K A T Y K E R A A T H P S P V A A K L F N I M H E K Q T N L C A S L D V R T T K E L L E L V E A L G P K I C L L K T H V D I L T D F S M E G T V K P L K A L S A K Y N F L L F E D R K F A D I G N T V K L Q Y S A G V Y R I A E W A D I T N A H G V V G P G I V S G L K Q A A E E V T K E P R G L L M L A E L S C K G S L S T G E Y T K G T V D I A K S D K D F V I G F I A Q R D M G G R D E G Y D W L I M T P G V G L D D K G D A L G Q Q Y R T V D D V V S T G S D I I I V G R G L F A K G R D A K V E G E R Y R K A G W E A Y L R R C G Q Q D M H K A T Y K E R A A T H P S P V A A K L F N I M H E K Q T N L C A S L D V R T T K E L L E L V E A L G P K I C L L K T H V D I L T D F S M E G T V K P L K A L S A K Y N F L L F E D R K F A D I G N T V K L Q Y S A G V Y R I A E W A D I T N A H G V V G P G I V S G L K Q A A E E V T K E P R G L L M L A E L S C K G S L S T G E Y T K G T V D I A K S D K D F V I G F I A Q R D M G G R D E G Y D W L I M T P G V G L D D K G D A L G Q Q Y R T V D D V V S T G S D I I I V G R G L F A K G R D A K V E G E R Y R K A G W E A Y L R R C G Q Q D </s> C A S L D K T H I F D R K N H L L A E L S C S S I A Q M T P G V G D G D G Q Q Y I V G R G L F A Y A D I G N T V L Q V V </s> O = c 1 c c ( O ) n ( [ C @ @ H ] 2 O [ C @ H ] ( C O [ P + ] ( = O ) ( = O ) [ O - ] ) [ C @ @ H ] ( O ) [ C @ H ] 2 O ) c ( = O ) [ n H ] 1
11.05
E G R E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P G N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S Y F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L S E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S Y F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L </s> Y V D T L G T W N Y G G G Y S G Y E S A D W H L Q E S I F R F Y F Y G W M P H G Y I </s> N c 1 c c c 2 c ( c 1 ) c ( - c 1 c c c c c 1 ) [ n + ] ( C C C C C C c 1 c n ( C C N C 3 = C 4 C = C C C = C 4 N c 4 c c c c c 4 3 ) n n 1 ) c 1 c c ( N ) c c c 2 1
11.05
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V M I G G I G G L T P V I G L D T G A D D T V I G G I G L T P V I G </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( C ( N ) = O ) c c 1
11.06
V T N S P V V V A L D Y H N R D D A L A F V D K I D P R D C R L K V G K E M F T L F G P Q F V R E L Q Q R G F D I F L D L K F H D I P N T A A H A V A A A A D L G V W M V N V H A S G G A R M M T A A R E A L V P F G K D A P L L I A V T V L T S M E A S D L V D L G M T L S P A D Y A E R L A A L T Q K C G L D G V V C S A Q E A V R F K Q V F G Q E F K L V T P G I R P Q G S E A G D Q R R I M T P E Q A L S A G V D Y M V I G R P V T Q S V D P A Q T L K A I N A S L Q V T N S P V V V A L D Y H N R D D A L A F V D K I D P R D C R L K V G K E M F T L F G P Q F V R E L Q Q R G F D I F L D L K F H D I P N T A A H A V A A A A D L G V W M V N V H A S G G A R M M T A A R E A L V P F G K D A P L L I A V T V L T S M E A S D L V D L G M T L S P A D Y A E R L A A L T Q K C G L D G V V C S A Q E A V R F K Q V F G Q E F K L V T P G I R P Q G S E A G D Q R R I M T P E Q A L S A G V D Y M V I G R P V T Q S V D P A Q T L K A I N A S L Q </s> V V A L D K V G K E M F D L K M N H I V T V L T S M V C S V T P G I R P S E A G D Q R R I M V I G R P V T Q H D I P N T A H A </s> O = c 1 c c ( O ) n ( [ C @ @ H ] 2 O [ C @ H ] ( C O [ P + ] ( = O ) ( = O ) [ O - ] ) [ C @ @ H ] ( O ) [ C @ H ] 2 O ) c ( = O ) [ n H ] 1
11.06
V T N S P V V V A L D Y H N R D D A L A F V D K I D P R D C R L K V G K E F T L F G P Q F V R E L Q Q R G F D I F L D L K F H D I P N T A A H A V A A A A D L G V W V N V H A S G G A R T A A R E A L V P F G K D A P L L I A V T V L T S E A S D L V D L G T L S P A D Y A E R L A A L T Q K C G L D G V V C S A Q E A V R F K Q V F G Q E F K L V T P G I R P Q G S E A G D Q R R I T P E Q A L S A G V D Y V I G R P V T Q S V D P A Q T L K A I N A S L Q V T N S P V V V A L D Y H N R D D A L A F V D K I D P R D C R L K V G K E F T L F G P Q F V R E L Q Q R G F D I F L D L K F H D I P N T A A H A V A A A A D L G V W V N V H A S G G A R T A A R E A L V P F G K D A P L L I A V T V L T S E A S D L V D L G T L S P A D Y A E R L A A L T Q K C G L D G V V C S A Q E A V R F K Q V F G Q E F K L V T P G I R P Q G S E A G D Q R R I T P E Q A L S A G V D Y V I G R P V T Q S V D P A Q T L K A I N A S L Q </s> V V A L D K V G K E F D L K N H V T V L T S V C S V T P G I R P S E A G D Q R R I V I G R P V T Q H D I P N T A H A </s> O = c 1 c c ( O ) n ( [ C @ @ H ] 2 O [ C @ H ] ( C O [ P + ] ( = O ) ( = O ) [ O - ] ) [ C @ @ H ] ( O ) [ C @ H ] 2 O ) c ( O ) n 1
11.06
R L I L A M D L M N R D D A L R V T G E V R E Y I D T V K I G Y P L V L S E G M D I I A E F R K R F G C R I I A D F K V A D I P E T N E K I C R A T F K A G A D A I I V H G F P G A D S V R A C L N V A E E M G R E V F L L T E M S H P G A E M F I Q G A A D E I A R M G V D L G V K N Y V G P S T R P E R L S R L R E I I G Q D S F L I S P G V G A Q G G D P G E T L R F A D A I I V G R S I Y L A D N P A A A A A G I I E S I R L I L A M D L M N R D D A L R V T G E V R E Y I D T V K I G Y P L V L S E G M D I I A E F R K R F G C R I I A D F K V A D I P E T N E K I C R A T F K A G A D A I I V H G F P G A D S V R A C L N V A E E M G R E V F L L T E M S H P G A E M F I Q G A A D E I A R M G V D L G V K N Y V G P S T R P E R L S R L R E I I G Q D S F L I S P G V G A Q G G D P G E T L R F A D A I I V G R S I Y L A D N P A A A A A G I I E S I </s> I L A M D K I G Y P L I D F K I H L T E M S H A I V G P S T R I S P G V G A Q G G I I V G R S I Y L I A D I P E T N K I P </s> O = c 1 c c ( O ) n ( [ C @ @ H ] 2 O [ C @ H ] ( C O [ P + ] ( = O ) ( = O ) [ O - ] ) [ C @ @ H ] ( O ) [ C @ H ] 2 O ) c ( = O ) [ n H ] 1
11.07
G Y T Y E D Y K N T A E W L L S H T K H R P Q V A I I C G S G L G G L T D K L T Q A Q I F D Y S E I P N F P R S T V P G H A G R L V F G F L N G R A C V M M Q G R F H M Y E G Y P L W K V T F P V R V F H L L G V D T L V V T N A A G G L N P K F E V G D I M L I R D H I N L P G F S G Q N P L R G P N D E R F G D R F P A M S D A Y D R T M R Q R A L S T W K Q M G E Q R E L Q E G T Y V M V A G P S F E T V A E C R V L Q K L G A D A V G M S T V P E V I V A R H C G L R V F G F S L I T N K V I M D Y E S L E K A N H E E V L A A G K Q A A Q K L E Q F V S I L M A S I P L P N G Y T Y E D Y K N T A E W L L S H T K H R P Q V A I I C G S G L G G L T D K L T Q A Q I F D Y S E I P N F P R S T V P G H A G R L V F G F L N G R A C V M M Q G R F H M Y E G Y P L W K V T F P V R V F H L L G V D T L V V T N A A G G L N P K F E V G D I M L I R D H I N L P G F S G Q N P L R G P N D E R F G D R F P A M S D A Y D R T M R Q R A L S T W K Q M G E Q R E L Q E G T Y V M V A G P S F E T V A E C R V L Q K L G A D A V G M S T V P E V I V A R H C G L R V F G F S L I T N K V I M D Y E S L E K A N H E E V L A A G K Q A A Q K L E Q F V S I L M A S I P L </s> F S V P H R H Y N A A G G Y V P S F E C V G M S L T N K V I A N H V L </s> O = c 1 [ n H ] c n c 2 c ( C [ N H 2 + ] [ C @ H ] ( C O ) [ C @ H ] ( O ) C O ) c [ n H ] c 1 2
11.07
K H N M K A F L D E L K A E N I K K F L Y N F T Q I P H L A G T E Q N F Q L A K Q I Q S Q W K E F G L D S V E L A H Y D V L L S Y P N K T H P N Y I S I I N E D G N E I F N T S L F E P P P P G Y E N V S D I V P P F S A F S P Q G M P E G D L V Y V N Y A R T E D F F K L E R D M K I N C S G K I V I A R Y G K V F R G N K V K N A Q L A G A K G V I L Y S D P A D Y F A P G V K S Y P D G W N L P G G G V Q R G N I L N L N G A G D P L T P G Y P A N E Y A Y R R G I A E A V G L P S I P V H P I G Y Y D A Q K L L E K M G G S A P P D S S W R G S L K V P Y N V G P G F T G N F S T Q K V K M H I H S T N E V T R I Y N V I G T L R G A V E P D R Y V I L G G H R D S W V F G G I D P Q S G A A V V H E I V R S F G T L K K E G W R P R R T I L F A S W D A E E F G L L G S T E W A E E N S R L L Q E R G V A Y I N A D S S I E G N Y T L R V D C T P L M Y S L V H N L T K E L K S P D E G F E G K S L Y E S W T K K S P S P E F S G M P R I S K L G S G N D F E V F F Q R L G I A S G R A R Y T K N W E T S G Y P L Y H S V Y E T Y E L V E K F Y D P M F K Y H L T V A Q V R G G M V F E L A N S I V L P F D C R D Y A V V L R K Y A D K I Y S I S M K H P Q E M K T Y S V S F D S L F S A V K N F T E I A S K F S E R L Q D F N P I V L R M M N D Q L M F L E R A F I D P L G L P D R P F Y R H V I Y A P S S H N K Y A G E S F P G I Y D A L F D I E S K V D P S K A W G E V K R Q I Y V A A F T V Q A A A E T L S E V A </s> A F Y G K V F R G Y Q R G N I L N L N G H D W I D A E E F G L L N D S S I E L R V D S P P R I S K G S G N D F E R R T K N W E S G Y Y H E R Y N K Y A G </s> O = C ( [ O - ] ) C C [ C @ H ] ( N C ( = O ) N [ C @ @ H ] ( C C C C N ( C c 1 c c c ( B r ) c c 1 ) C ( = O ) c 1 c c c ( N 2 C C N ( c 3 c c c c c 3 ) C C 2 ) n c 1 ) C ( = O ) [ O - ] ) C ( = O ) [ O - ]
11.1
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V K M I G G I G L P V I R R L L D G A D D V I G G I G T P V I </s> C / C = C / [ C @ @ ] 1 ( C C c 2 c c c c c 2 ) C C ( O ) = C ( [ C @ H ] ( C C ) c 2 c c c c ( N S ( = O ) ( = O ) c 3 c c c ( C ( F ) ( F ) F ) c n 3 ) c 2 ) C ( = O ) O 1
11.1
S I S R F G V N T E N E D H L A K E L E D L N K W G L N I F N V A G Y S H N R P L T C I M Y A I F Q E R D L L K T F R I S S D T F I T Y M M T L E D H Y H S D V A Y H N S L H A A D V A Q S T H V L L S T P A L D A V F T D L E I L A A I F A A A I H D V D H P G V S N Q F L I N T N S E L A L M Y N D E S V L E N H H L A V G F K L L Q E E H C D I F M N L T K K Q R Q T L R K M V I D M V L A T D M S K H M S L L A D L K T M V E T K K V T S S G V L L L D N Y T D R I Q V L R N M V H C A D L S N P T K S L E L Y R Q W T D R I M E E F F Q Q G D K E R E R G M E I S P M C D K H T A S V E K S Q V G F I D Y I V H P L W E T W A D L V Q P D A Q D I L D T L E D N R N W Y Q A M I P Q A </s> Y H H D V H D H G V S N Q F L L E A T D M S H M H A D L S N P T Y Q W T D R I M E F F Q E S P M C A S V K S Q V G F I Y I V </s> C O c 1 c c c c ( N c 2 c ( C ( N ) = O ) c n c 3 c ( C ) c c ( S ( = O ) ( = O ) c 4 c c c c ( C ( = O ) N ( C ) C ) c 4 ) c c 2 3 ) c 1
11.11
G E I T F S D Y L G L M T C V Y E W A D S Y D S K D W D R L R K V I A P T L R I D Y R S F L D K L W E A M P A E E F V G M V S S K Q V L G D P T L R T Q H F I G G T R W E K V S E D E V I G Y H Q L R V P H Q R Y K D T T M K E V T M K G H A H S A N L H W Y K K I D G V W K F A G L K P D I R W G E F D F D R I F E D G R E T F G </s> W Y I D Y F L F M V Q V L H L R V H A H S N H L K P D I F F D G R F G </s> N # C c 1 n n c 2 c c c c c 2 c 1 N C C C ( c 1 c c c c c 1 ) c 1 c c c c c 1
11.15
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R P L L L D T G A D D T V K M I G G I G G F I V L T P V N I G R N R P L L L D T G A D D T V L E K I G G I G G F I V L T P V N I I G R N </s> C O C ( = O ) N [ C @ H ] ( C ( = O ) N [ C @ @ H ] ( C ) C C C [ C @ @ H ] ( C O ) N ( C C C ( C ) C ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1 ) C ( c 1 c c c c c 1 ) c 1 c c c c c 1
11.15
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T I L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T I L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T I I G G I G L T P V I G R R L D T G A D D T I K I G G I G L T P V I G </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.2
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N V I G R N L M T Q I G M T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N V I G R N L M T Q I G M T L N F </s> R L D T G A D D T V K I G G I G L T P V V G L D T G A D D T V I G G I G L T P V V G R </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) O [ C @ H ] 2 C O [ C @ H ] 3 O C C [ C @ H ] 3 2 ) c c 1
11.22
S S N D N I E L V D F Q N I M F Y G D A E V G D N Q Q P F T F I L D T G S A N L W V P S V K C T T A G C L T K H L Y D S S K S R T Y E K D G T K V E M N Y V S G T V S G F F S K D L V T V G N L S L P Y K F I E V I D T N G F E P T Y T A S T F D G I L G L G W K D L S I G S V D P I V V E L K N Q N K I E N A L F T F Y L P V H D K H T G F L T I G G I E E R F Y E G P L T Y E K L N H D L Y W Q I T L D A H V G N I M L E K A N C I V D S G T S A I T V P T D F L N K M L Q N L D V I K V P F L P F Y V T L C N N S K L P T F E F T S E N G K Y T L E P E Y Y L Q H I E D V G P G L C M L N I I G L D F P V P T F I L G D P F M R K Y F T V F D Y D N H S V G I A L A K K N L </s> F I M Y I L D T G S A N W E M N Y V S G T V F T Y S F G I L G L G K D L S I L Y I D S G T S A I T V P F Y Q M N I I G L F P I G D P </s> C C ( C ) C C ( = O ) N [ C @ H ] ( C ( = O ) N [ C @ H ] ( C ( = O ) N [ C @ @ H ] ( C C ( C ) C ) [ C @ @ H ] ( O ) C C ( = O ) N [ C @ @ H ] ( C ) C ( = O ) N [ C @ @ H ] ( C C ( C ) C ) [ C @ @ H ] ( O ) C C ( = O ) [ O - ] ) C ( C ) C ) C ( C ) C
11.22
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D I G G I G G F T P V N I R R L D T G A D D T V K M I G G I G L T P V I G </s> C C ( = O ) c 1 c c c c ( N 2 C [ C @ @ H ] ( C ( = O ) N [ C @ @ H ] ( C c 3 c c c c c 3 ) [ C @ H ] ( O ) C N ( C C ( C ) C ) S ( = O ) ( = O ) c 3 c c c 4 c ( c 3 ) O C O 4 ) O C 2 = O ) c 1
11.22
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D V I G G I G G F T P V I R R L D T G A D D T V K I G G I G L T P V I G </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) [ C @ @ H ] 2 C N ( c 3 c c c c ( C ( F ) ( F ) F ) c 3 ) C ( = O ) O 2 ) c c 1
11.22
G G T I A R T I V L Q E S I G K G R F G E V W R G K W R G E E V A V K I F S S R E E R S W F R E A E I Y Q T V M L R H E N I L G F I A A D N K D N G T W T Q L W L V S D Y H E H G S L F D Y L N R Y T V T V E G M I K L A L S T A S G L A H L H M E I V G T Q G K P A I A H R D L K S K N I L V K K N G T C C I A D L G L A V R H D S A T D T I D I A P N H R V G T K R Y M A P E V L D D S I N M K H F E S F K R A D I Y A M G L V F W E I A R R C S I G G I H E D Y Q L P Y Y D L V P S D P S V E E M R K V V C E Q K L R P N I P N R W Q S C E A L R V M A K I M R E C W Y A N G A A R L T A L R I K K T L S Q L S Q Q E G I </s> E S I G K G R F G E V W R V A V K I F E A Y L G F I A A W L V S D Y H E H G S D K K N I L V C I A D L G </s> C O c 1 c c c ( - c 2 c ( - c 3 c c n c ( N C ( C ) = O ) c 3 ) [ n H ] c 3 c c c n c 2 3 ) n c 1
11.23
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F </s> R L D T G A D D T V I G G I G F L T P V I R R L D T G A D D T V K M I G G I G L T P V I G </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) O [ C @ H ] 2 C O [ C @ H ] 3 O [ C @ @ H ] 4 O C C [ C @ @ H ] 4 [ C @ H ] 3 2 ) c c 1
11.26
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V I G G I G I L T P V I R L D T G A D D T V I G G I G G F L T P V I G R </s> C S C [ C @ H ] ( N C ( = O ) C O c 1 c c c c 2 c n c c c 1 2 ) C ( = O ) N [ C @ @ H ] ( C c 1 c c c c c 1 ) [ C @ H ] ( O ) C ( = O ) N 1 C S C [ C @ H ] 1 C ( = O ) N C ( C ) ( C ) C
11.28
M E N G Y T Y E D Y K N T A E W L L S H T K H R P Q V A I I C G S G L G G L T D K L T Q A Q I F D Y S E I P N F P R S T V P G H A G R L V F G F L N G R A C V M M Q G R F H M Y E G Y P L W K V T F P V R V F H L L G V D T L V V T N A A G G L N P K F E V G D I M L I R D H I N L P G F S G Q N P L R G P N D E R F G D R F P A M S D A Y D R T M R Q R A L S T W K Q M G E Q R E L Q E G T Y V M V A G P S F E T V A E C R V L Q K L G A D A V G M S T V P E V I V A R H C G L R V F G F S L I T N K V I M D Y E S L E K A N H E E V L A A G K Q A A Q K L E Q F V S I L M A S I P L P D </s> S H Y N A A G G Y V P S F E V G M S L T N K V A N H V L </s> O = c 1 [ n H ] c n c 2 c ( C [ N H 2 + ] C ( C O ) C O ) c [ n H ] c 1 2
11.3
M K T I F S G I Q P S G V I T I G N Y I G A L R Q F V E L Q H E Y N C Y F C I V D Q H A I T V W Q D P H E L R Q N I R R L A A L Y L A V G I D P T Q A T L F I Q S E V P A H A Q A A W M L Q C I V Y I G E L E R M T Q F K E K S A G K E A V S A G L L T Y P P L M A A D I L L Y N T D I V P V G E D Q K Q H I E L T R D L A E R F N K R Y G E L F T I P E A R I P K V G A R I M S L V D P T K K M S K S D P N P K A Y I T L L D D A K T I E K K I K S A V T D S E G T I R Y D K E A K P G I S N L L N I Y S T L S G Q S I E E L E R Q Y E G K G Y G V F K A D L A Q V V I E T L R P I Q E R Y H H W M E S E E L D R V L D E G A E K A N R V A S E M V R K M E Q A M G L G R R R M K T I F S G I Q P S G V I T I G N Y I G A L R Q F V E L Q H E Y N C Y F C I V D Q H A I T V W Q D P H E L R Q N I R R L A A L Y L A V G I D P T Q A T L F I Q S E V P A H A Q A A W M L Q C I V Y I G E L E R M T Q F K E K S A G K E A V S A G L L T Y P P L M A A D I L L Y N T D I V P V G E D Q K Q H I E L T R D L A E R F N K R Y G E L F T I P E A R I P K V G A R I M S L V D P T K K M S K S D P N P K A Y I T L L D D A K T I E K K I K S A V T D S E G T I R Y D K E A K P G I S N L L N I Y S T L S G Q S I E E L E R Q Y E G K G Y G V F K A D L A Q V V I E T L R P I Q E R Y H H W M E S E E L D R V L D E G A E K A N R V A S E M V R K M E Q A M G L G R R R </s> S G I Q P S G V I T I G N Y I G A L Q F C I V H A T V Q L Y Q K L Y M V P V G E D Q K H I R I P V G A R I M S K K M S K S D P Y N I </s> N c 1 n c n c 2 c 1 n c n 2 [ C @ @ H ] 1 O [ C @ H ] ( C O [ P @ @ ] ( = O ) ( [ O - ] ) O [ P @ ] ( = O ) ( [ O - ] ) O [ P + ] ( = O ) ( = O ) [ O - ] ) [ C @ @ H ] ( O ) [ C @ H ] 1 O
11.3
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V I G G I G L T P V I G R L D T G A D D T V I G G I G L T P V I G </s> C O c 1 c c ( C N 2 C ( = O ) N ( C c 3 c c c ( O ) c ( O C ) c 3 ) N ( C c 3 c c c c c 3 ) C [ C @ @ H ] ( O ) [ C @ H ] 2 C c 2 c c c c c 2 ) c c c 1 O
11.3
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V I G G I L T P V I R R L D T G A D D T V K I G G I G L T P V I G </s> C c 1 c c c c ( C ) c 1 O C C ( = O ) N [ C @ @ H ] ( C c 1 c c c c c 1 ) [ C @ @ H ] ( O ) C [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) [ C @ H ] ( C ( C ) C ) N 1 C C C N C 1 = O
11.3
Q V L V P N L N P T P E N L E V V G D G F K I T S S I N L V G E E E A D E N A V N A L R E F L T A N N I E I N S E N D P N S T T L I I G E V D D D I P E L D E A L N G T T A E N L K E E G Y A L V S N D G K I A I E G K D G D G T F Y G V Q T F K Q L V K E S N I P E V N I T D Y P T V S A R G I V E G F Y G T P W T H Q D R L D Q I K F Y G E N K L N T Y I Y A P K D D P Y H R E K W R E P Y P E S E M Q R M Q E L I N A S A E N K V D F V F G I S P G I D I R F D G D A G E E D F N H L I T K A E S L Y D M G V R S F A I Y W D D I Q D K S A A K H A Q V L N R F N E E F V K A K G D V K P L I T C P T E Y D T G A M V S N G Q P R A Y T R I F A E T V D P S I E V M W T G P G V V T N E I P L S D A Q L I S G I Y D R N M A V W W N Y P V T D Y F K G K L A L G P M H G L D K G L N Q Y V D F F T V N P M E H A E L S K I S I H T A A D Y S W N M D N Y D Y D K A W N R A I D M L Y G D L A E D M K V F A N H S T R M D N K T W A K S G R E D A P E L R A K M D E L W N K L S S K E D A S A L I E E L Y G E F A R M E E A C N N L K A N L P E V A L E E C S R Q L D E L I T L A Q G D K A S L D M I V A Q L N E D T E A Y E S A K E I A Q N K L N T A L S S F A V I S E K V A Q S F I Q E A L S F D L T L I Q V L V P N L N P T P E N L E V V G D G F K I T S S I N L V G E E E A D E N A V N A L R E F L T A N N I E I N S E N D P N S T T L I I G E V D D D I P E L D E A L N G T T A E N L K E E G Y A L V S N D G K I A I E G K D G D G T F Y G V Q T F K Q L V K E S N I P E V N I T D Y P T V S A R G I V E G F Y G T P W T H Q D R L D Q I K F Y G E N K L N T Y I Y A P K D D P Y H R E K W R E P Y P E S E M Q R M Q E L I N A S A E N K V D F V F G I S P G I D I R F D G D A G E E D F N H L I T K A E S L Y D M G V R S F A I Y W D D I Q D K S A A K H A Q V L N R F N E E F V K A K G D V K P L I T C P T E Y D T G A M V S N G Q P R A Y T R I F A E T V D P S I E V M W T G P G V V T N E I P L S D A Q L I S G I Y D R N M A V W W N Y P V T D Y F K G K L A L G P M H G L D K G L N Q Y V D F F T V N P M E H A E L S K I S I H T A A D Y S W N M D N Y D Y D K A W N R A I D M L Y G D L A E D M K V F A N H S T R M D N K T W A K S G R E D A P E L R A K M D E L W N K L S S K E D A S A L I E E L Y G E F A R M E E A C N N L K A N L P E V A L E E C S R Q L D E L I T L A Q G D K A S L D M I V A Q L N E D T E A Y E S A K E I A Q N K L N T A L S S F A V I S E K V A Q S F I Q E A L S F D L T L I </s> G F Y A K Y D D T C P Y M W T V V W N V T D Y N P W L S S K F D L T L I </s> O = C ( C C S ) N [ C @ H ] 1 c 2 [ n H + ] c ( C C c 3 c c c c c 3 ) c n 2 [ C @ H ] ( C O ) [ C @ @ H ] ( O ) [ C @ @ H ] 1 O
11.3
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> L D T G A D D T V I G G I G L T P V I G R R L D T G A D D T V K I G G I G L T P V I G </s> C C C ( C C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F </s> R L D T G A D D T V K M I G G I G L T P V I G L D T G A D D T V I G G I G L T P V I </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) O [ C @ @ H ] 2 C [ C @ @ H ] 3 [ C @ @ H ] ( O ) C O [ C @ @ H ] 3 C 2 ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V L K M I G G I G G F I V L T P V N I I G R N R L L D T G A D D T V I G G I G G L T P V N I I G R N </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V L K M I G G I G G F I V L T P V N I I G R N R L L D T G A D D T V I G G I G G I L T P V N I I G R N </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V L K M I G G I G G F I V L T P V N I I G R N R L L D T G A D D T V M I G G I G G I L P T P V N I I G R N </s> C C C ( C C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C C 1 C C C C C 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P I N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P I N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V L K M I G G I G G F I V L T P I N I I G R N R L L D T G A D D T V I G G I G G L T P I N I I G R N </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P I N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P I N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V L K M I G G I G G F I V L T P I N I I G R N R L L D T G A D D T V M I G G I G G I L T P I N I I G R N </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P I N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P I N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V L K M I G G I G G F I V T L P T P I N I I G R N R L L D T G A D D T V I G G I G G I L T P I N I I G R N </s> C C C ( C C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C C 1 C C C C C 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) C 1 C C C ( [ N H 3 + ] ) C C 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L M T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L M T Q I G C T L N F </s> R L L D T G A D D T V L K M I G G I G G F I V L T P V N I I G R N R L L D T G A D D T V I G G I G G L T P V N I I G R N </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N V M T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N V M T Q I G C T L N F </s> R L L D T G A D D T V K M I G G I G G I L T P V N I I G R N R L L D T G A D D T V K M I G G I G G F I V L T P V N I I G R N </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N V L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N V L T Q I G C T L N F </s> R L L D T G A D D T V K M I G G I G G F I V L T P V N I I G R N R L L D T G A D D T V I G G I G G L T P V N I I G R N </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M N L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V L K M I G G I G G F I V L T P V N I I G R N R L L D T G A D D T V I G G I G G I L P T P V N I I G R N </s> C C C ( C C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( C O ) c c 1
11.31
S G P V P S R A R V Y T D V N T H R P R E Y W D Y E S H V V E W G N Q D D Y Q L V R K L G R G K Y S E V F E A I N I T N N E K V V V K I L K P V K K K K I K R E I K I L E N L R G G P N I I T L A D I V K D P V S R T P A L V F E H V N N T D F K Q L Y Q T L T D Y D I R F Y M Y E I L K A L D Y C H S M G I M H R D V K P H N V M I D H E H R K L R L I D W G L A E F Y H P G Q E Y N V R V A S R Y F K G P E L L V D Y Q M Y D Y S L D M W S L G C M L A S M I F R K E P F F H G H D N Y D Q L V R I A K V L G T E D L Y D Y I D K Y N I E L D P R F N D I L G R H S R K R W E R F V H S E N Q H L V S P E A L D F L D K L L R Y D H Q S R L T A R E A M E H P Y F Y T V V K D Q A </s> R K L G R G K Y S E V F E K V V V K I L K E L I T L A L V F E H V N N T D K H N M I R L I D W G L </s> C C ( = O ) N c 1 c c ( N c 2 c c ( N C 3 C = C 3 ) n 3 n c c ( C # N ) c 3 n 2 ) c c c 1 C
11.32
A P D S V D Y R K K G Y V T P V K N Q G Q C G S C W A F S S V G A L E G Q L K K K T G K L L N L S P Q N L V D C V S E N D G C G G G Y M T N A F Q Y V Q K N R G I D S E D A Y P Y V G Q E E S C M Y N P T G K A A K C R G Y R E I P E G N E K A L K R A V A R V G P V S V A I D A S L T S F Q F Y S K G V Y Y D E S C N S D N L N H A V L A V G Y G I Q K G N K H W I I K N S W G E N W G N K G Y I L M A R N K N N A C G I A N L A S F P K M </s> N Q G Q C G S C W A F S V S E N D G C G G G Y M T N K Y S V A I D A S T F Q F Y N L N H A V N S W G N W G L </s> C C ( C ) C [ C @ H ] ( N C ( = O ) c 1 c c 2 c c ( O C C [ N H + ] 3 C C O C C 3 ) c c c 2 o 1 ) C ( = O ) N [ C @ H ] 1 C C C N ( C ( = O ) C c 2 c c c c ( - c 3 c c c c n 3 ) c 2 ) C [ C @ @ H ] 1 O
11.32
N P F D L L L L P T W I V P V E P A G V V L R D H A L G I R D G Q I A L V A P R E Q A M R H G A T E I R E L P G M L L A P G L V N A H G H S A M S L F R G L A D D L P L M T W L Q D H I W P A E G Q W V S E D F I R D G T E L A I A E Q V K G G I T C F S D M Y F Y P Q A I C G V V H D S G V R A Q V A I P V L D F P I P G A R D S A E A I R Q G M A L F D D L K H H P R I R I A F G P H A P Y T V S D D K L E Q I L V L T E E L D A S I Q M H V H E T A F E V E Q A M E R N G E R P L A R L H R L G L L G P R F Q A V H M T Q V D N D D L A M L V E T N S S V I H C P E S N L K L A S G F C P V E K L W Q A G V N V A I G T D G A A S N N D L D L L G E T R T A A L L A K A V Y G Q A T A L D A H R A L R M A T L N G A R A L G L E R L I G S L E A G K A A D L V A F D L S G L A Q Q P V Y D P V S Q L I Y A S G R D C V R H V W V G G R Q L L D D G R L L R H D E Q R L I A R A R E W G A K I A A </s> H G H M L W L I W E M Y F A I P V L I G P H A Y H E V H C S L D G S </s> C S C [ C @ H ] 1 O [ C @ @ H ] ( n 2 c n c 3 c 2 N = C N C [ C @ H ] 3 O ) [ C @ H ] ( O ) [ C @ @ H ] 1 O
11.34
Q V L V P N L N P T P E N L E V V G D G F K I T S S I N L V G E E E A D E N A V N A L R E F L T A N N I E I N S E N D P N S T T L I I G E V D D D I P E L D E A L N G T T A E N L K E E G Y A L V S N D G K I A I E G K D G D G T F Y G V Q T F K Q L V K E S N I P E V N I T D Y P T V S A R G I V E G F Y G T P W T H Q D R L D Q I K F Y G E N K L N T Y I Y A P K D D P Y H R E K W R E P Y P E S E M Q R M Q E L I N A S A E N K V D F V F G I S P G I D I R F D G D A G E E D F N H L I T K A E S L Y D M G V R S F A I Y W D D I Q D K S A A K H A Q V L N R F N E E F V K A K G D V K P L I T V P T E Y D T G A M V S N G Q P R A Y T R I F A E T V D P S I E V M W T G P G V V T N E I P L S D A Q L I S G I Y D R N M A V W W N Y P V T D Y F K G K L A L G P M H G L D K G L N Q Y V D F F T V N P M E H A E L S K I S I H T A A D Y S W N M D N Y D Y D K A W N R A I D M L Y G D L A E D M K V F A N H S T R M D N K T W A K S G R E D A P E L R A K M D E L W N K L S S K E D A S A L I E E L Y G E F A R M E E A C N N L K A N L P E V A L E E C S R Q L D E L I T L A Q G D K A S L D M I V A Q L N E D T E A Y E S A K E I A Q N K L N T A L S S F A V I S E K V A Q S F I Q E A L S F D L T L I Q V L V P N L N P T P E N L E V V G D G F K I T S S I N L V G E E E A D E N A V N A L R E F L T A N N I E I N S E N D P N S T T L I I G E V D D D I P E L D E A L N G T T A E N L K E E G Y A L V S N D G K I A I E G K D G D G T F Y G V Q T F K Q L V K E S N I P E V N I T D Y P T V S A R G I V E G F Y G T P W T H Q D R L D Q I K F Y G E N K L N T Y I Y A P K D D P Y H R E K W R E P Y P E S E M Q R M Q E L I N A S A E N K V D F V F G I S P G I D I R F D G D A G E E D F N H L I T K A E S L Y D M G V R S F A I Y W D D I Q D K S A A K H A Q V L N R F N E E F V K A K G D V K P L I T V P T E Y D T G A M V S N G Q P R A Y T R I F A E T V D P S I E V M W T G P G V V T N E I P L S D A Q L I S G I Y D R N M A V W W N Y P V T D Y F K G K L A L G P M H G L D K G L N Q Y V D F F T V N P M E H A E L S K I S I H T A A D Y S W N M D N Y D Y D K A W N R A I D M L Y G D L A E D M K V F A N H S T R M D N K T W A K S G R E D A P E L R A K M D E L W N K L S S K E D A S A L I E E L Y G E F A R M E E A C N N L K A N L P E V A L E E C S R Q L D E L I T L A Q G D K A S L D M I V A Q L N E D T E A Y E S A K E I A Q N K L N T A L S S F A V I S E K V A Q S F I Q E A L S F D L T L I </s> L S S K F D L T L I G F Y A K Y D D V P Y M W T V V W N V T D Y N W </s> C C ( C ) C ( = O ) N [ C @ H ] 1 c 2 [ n H + ] c ( C C c 3 c c c c c 3 ) c n 2 [ C @ H ] ( C O ) [ C @ @ H ] ( O ) [ C @ @ H ] 1 O
11.35
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F </s> R L D T G A D D T V K I G G I G L T P V I L D T G A D D T V I G G I G L T P V I </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ @ H ] 1 C [ C @ @ H ] 2 C C O [ C @ @ H ] 2 C 1 ) S ( = O ) ( = O ) c 1 c c c ( C O ) c c 1
11.4
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V I G G I G L T P V I R L D T G A D D T V I G G I G L T P V I R </s> C C ( C ) [ C @ H ] ( N C ( = O ) N ( C ) C c 1 c c c c n 1 ) C ( = O ) N [ C @ @ H ] ( C c 1 c c c c c 1 ) C [ C @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) [ C @ @ H ] ( N C ( = O ) N ( C ) C c 1 c c c c n 1 ) C ( C ) C
11.4
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D I G G I G F T P V I R R L D T G A D D T V K I G G I G L T P V I G </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) [ C @ @ H ] 2 C N ( c 3 c c c ( C ( C ) = O ) c c 3 ) C ( = O ) O 2 ) c c 1
11.41
Y N V F P R T L K W S K M N L T Y R I V N Y T P D M T H S E V E K A F K K A F K V W S D V T P L N F T R L H D G I A D I M I S F G I K E H G D F Y P F D G P S G L L A H A F P P G P N Y G G D A H F D D D E T W T S S S K G Y N L F L V A A H E F G H S L G L D H S K D P G A L M F P I Y T Y T G K S H F M L P D D D V Q G I Q S L Y G P G D E D P </s> A K G L L A H F W T S S S Y N L F L V A A H E F H H S D P G A L M F P I Y T Y T G K S H F M L P D D </s> C O c 1 c c c c ( C N C ( = O ) c 2 n c 3 c c c ( F ) c ( O C C c 4 c c c ( C ( = O ) [ O - ] ) c c 4 ) c 3 c ( = O ) [ n H ] 2 ) c 1
11.44
D V Q L Q E S G P G L V K P S Q S L S L T C T V T G F S I T S P Y A W N W I R Q F P G N T L E W M G Y I S Y R G S T T Y H P S L K S R I S I T R D T S K N Q F F L Q L N S V T T E D T A T Y F C S S Y G N Y G A Y S G Q G T L V T V S A A K T T P P S V Y P L A P G S M V T L G C L V K G Y F P E P V T V T W N S G S L S S G V H T F P A V L Q S D L Y T L S S S V T V P S S T W P S E T V T C N V A H P A S S T K V D K K I V P R D V L L T Q I P L S L P V S L G D Q A S I S C R S S Q S I V H S N G N T Y L E W Y L Q K P G Q S P K L L I Y K V S T R F S G V P D R F S G S G S G T D F T L K I S R V E A E D L G V Y Y C F Q G S H V P L T F G A G T Q L E L K R A D A A P T V S I F P P S S E Q L T S G G A S V V C F L N N F Y P K D I N V K W K I D G S E R Q N G V L N S W T D Q D S K D S T Y S M S S T L T L T K D E Y E R H N S Y T C E A T H K T S P I V K S F N R </s> S P Y A W N W I W G Y I Y R T S S Y G N G A Y S H S N N T Y L E Y L Y K F Q G S H V L F </s> C N ( C c 1 c n c 2 n c ( N ) n c ( N ) c 2 n 1 ) c 1 c c c ( C ( = O ) N [ C @ @ H ] ( C C C ( = O ) [ O - ] ) C ( = O ) [ O - ] ) c c 1
11.52
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V I G G I G F L T P V I R R L D T G A D D T V K I G G I G L T P V I G </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O C C N C ( = O ) C ( C l ) C l ) S ( = O ) ( = O ) c 1 c c c ( O C ) c c 1
11.52
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D V I G G I G T P V I R R L D T G A D D T V K M I G G I G L T P V I G </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O C [ C @ @ H ] 1 C C C ( = O ) N 1 ) S ( = O ) ( = O ) c 1 c c c 2 n c s c 2 c 1
11.52
P L E S Q Y Q V G P L L G S G G F G S V Y S G I R V S D N L P V A I K H V E K D R I S D W G E L P N G T R V P M E V V L L K K V S S G F S G V I R L L D W F E R P D S F V L I L E R P E P V Q D L F D F I T E R G A L Q E E L A R S F F W Q V L E A V R H C H N C G V L H R D I K D E N I L I D L N R G E L K L I D F G S G A L L K D T V Y T D F D G T R V Y S P P E W I R Y H R Y H G R S A A V W S L G I L L Y D M V C G D I P F E H D E E I I R G Q V F F R Q R V S S E C Q H L I R W C L A L R P S D R P T F E E I Q N H P W M Q D V L L P Q E T A E I H L H </s> P L L G S G F G S V Y S G P V A I K H V E L I R L L I L E R P E P V Q D L F D H K D E N I L I K L I D F G S </s> O = C ( N c 1 c [ n H ] c 2 n c c ( - c 3 c c c c c 3 F ) c c 1 2 ) c 1 c n n 2 c c c ( N C [ C @ H ] 3 C C [ N H 2 + ] C [ C @ @ H ] 3 F ) n c 1 2
11.52
P L E S Q Y Q V G P L L G S G G F G S V Y S G I R V S D N L P V A I K H V E K D R I S D W G E L P N G T R V P M E V V L L K K V S S G F S G V I R L L D W F E R P D S F V L I L E R P E P V Q D L F D F I T E R G A L Q E E L A R S F F W Q V L E A V R H C H N C G V L H R D I K D E N I L I D L N R G E L K L I D F G S G A L L K D T V Y T D F D G T R V Y S P P E W I R Y H R Y H G R S A A V W S L G I L L Y D M V C G D I P F E H D E E I I R G Q V F F R Q R V S S E C Q H L I R W C L A L R P S D R P T F E E I Q N H P W M Q D V L L P Q E T A E I H L H </s> L G S G F G V S V A K E L I L E R P E V Q D F D D E N I L L I D F G </s> O = C ( N c 1 c [ n H ] c 2 n c c ( - c 3 c c c c c 3 F ) c c 1 2 ) c 1 c n n 2 c c c ( N C [ C @ H ] 3 C C [ N H 2 + ] C [ C @ @ H ] 3 F ) n c 1 2
11.52
G S K V T T V V A T P G Q G P D R P Q E V S Y T D T K V I G N G S F G V V Y Q A K L C D S G E L V A I K K V L Q D K R F K N R E L Q I M R K L D H C N I V R L R Y F F Y S S D E V Y L N L V L D Y V P E T V Y R V A R H Y S R A K Q T L P V I Y V K L Y M Y Q L F R S L A Y I H S F G I C H R D I K P Q N L L L D P D T A V L K L C D F G S A K Q L V R G E P N V S I C S R Y Y R A P E L I F G A T D Y T S S I D V W S A G C V L A E L L L G Q P I F P G D S G V D Q L V E I I K V L G T P T R E Q I R E M N P N Y T E F K F P Q I K A H P W T K V F R P R T P P E A I A L C S R L L E Y T P T A R L T P L E A C A H S F F D E L R D P N V K L P N G R D T P A L F N F T T Q E L S S N P P L A T I L I P P H A R I V T T V V A T P G Q G P D R P Q E V S Y T D T K V I G N G S F G V V Y Q A K L C D S G E L V A I K K V L Q D K R F K N R E L Q I M R K L D H C N I V R L R Y F F Y S S G E K K D E V Y L N L V L D Y V P E T V Y R V A R H Y S R A K Q T L P V I Y V K L Y M Y Q L F R S L A Y I H S F G I C H R D I K P Q N L L L D P D T A V L K L C D F G S A K Q L V R G E P N V S I C S R Y Y R A P E L I F G A T D Y T S S I D V W S A G C V L A E L L L G Q P I F P G D S G V D Q L V E I I K V L G T P T R E Q I R E M N P N Y T E F K F P Q I K A H P W T K V F R P R T P P E A I A L C S R L L E Y T P T A R L T P L E A C A H S F F D E L R D P N V K L P N G R D T P A L F N F T T Q E L S S N P P L A T I L I P P H A R </s> V I G N G S F G V V Y Q V A I K E M V R L V L D Y V P E T V Y R R K P Q N L L L K L C D F G </s> C c 1 c n c ( - c 2 c n c ( N C C N c 3 c c c ( C # N ) c n 3 ) n c 2 - c 2 c c c ( C l ) c c 2 C l ) [ n H ] 1
11.52
G H M T I A R D I V L Q E S I G K G R F G E V W R G K W R G E E V A V K I F S S R E E R S W F R E A E I Y Q T V M L R H E N I L G F I A A D N K D N G T W T Q L W L V S D Y H E H G S L F D Y L N R Y T V T V E G M I K L A L S T A S G L A H L H M E I V G T Q G K P A I A H R D L K S K N I L V K K N G T C C I A D L G L A V R H D S A T D T I D I A P N H R V G T K R Y M A P E V L D D S I N M K H F E S F K R A D I Y A M G L V F W E I A R R C S I G G I H E D Y Q L P Y Y D L V P S D P S V E E M R K V V C E Q K L R P N I P N R W Q S C E A L R V M A K I M R E C W Y A N G A A R L T A L R I K K T L S Q L S Q Q E </s> E S I G K G R F G E V W R V A V K I F E A Y L G F I A A W L V S D Y H E H G S D K K N I L V C I A D L G </s> C O c 1 c c c ( - c 2 c ( - c 3 c c n c ( N C ( C ) = O ) c 3 ) [ n H ] c 3 c c c n c 2 3 ) c n 1
11.54
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F </s> R L D T G A D D T V K M I G G I G L T P V I G R L D T G A D D T V I G G I G F L T P V I G R </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) O [ C @ H ] 2 C O [ C @ H ] 3 O C [ C @ H ] ( O C ) [ C @ H ] 3 2 ) c c 1
11.57
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G M T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G M T L N F </s> R L D T G A D D T V K M I G G I G L T P V I G L D T G A D D T V I G G I G L T P V N I G </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) O [ C @ H ] 2 C O [ C @ H ] 3 O C C [ C @ H ] 3 2 ) c c 1
11.57
M K I G I I G A M Q Q E V A I L K D L I E D V Q E V N Q A G C T F Y S G Q I Q G V D V V L L Q S G I G K V S A A L G T A L L I S Q Y A P D V V I N T G S A G G F D A S L N V G D V V I S S E V R H H D A D V T A F G Y E I G Q M A G Q P A A F K A D E K L M T V A E Q A L A Q L P N T H A V R G L I C T G D A F V C T A E R Q Q F I R Q H F P S V V A V E M E A S A I A Q T C H Q F K V P F V V V R A I S D V A D K E S P L S F E E F L P L A A K S S S A M V L K M V E L L K E N L Y F Q M K I G I I G A M Q Q E V A I L K D L I E D V Q E V N Q A G C T F Y S G Q I Q G V D V V L L Q S G I G K V S A A L G T A L L I S Q Y A P D V V I N T G S A G G F D A S L N V G D V V I S S E V R H H D A D V T A F G Y E I G Q M A G Q P A A F K A D E K L M T V A E Q A L A Q L P N T H A V R G L I C T G D A F V C T A E R Q Q F I R Q H F P S V V A V E M E A S A I A Q T C H Q F K V P F V V V R A I S D V A D K E S P L S F E E F L P L A A K S S S A M V L K M V E L L K E N L Y F Q </s> A M E G I G G S A G G H G A F V C V E M E R A S D V A D S F L V F Y A </s> C S C [ C @ H ] 1 C [ N @ @ H + ] ( C c 2 c [ n H ] c 3 c ( N ) n c n c 2 3 ) C [ C @ @ H ] 1 O
11.59
P K A L I V Y G S T T G N T E Y T A E T I A R E L A D A G Y E V D S R D A A S V E A G G L F E G F D L V L L G C S T W G D D S I E L Q D D F I P L F D S L E E T G A Q G R K V A C F G C G A S S Y E Y F C G A V D A I E E K L K N L G A E I V Q D G L R I D G D P R A A R D D I V G W A H D V R G A I </s> Y G S T T G N T E Y T A G C S T W G D D S I E Q D D F G C G A S S Y E Y F C G A V R I D G D P R </s> C c 1 c c 2 c ( c c 1 C ) N ( C [ C @ H ] ( O ) [ C @ H ] ( O ) [ C @ H ] ( O ) C O [ P + ] ( = O ) ( = O ) [ O - ] ) c 1 [ n H ] c ( = O ) [ n H ] c ( = O ) c 1 N 2
11.59
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G M T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G M T L N F </s> R L D T G A D D T V K I G G I G L T P V I G R L D T G A D D T V I G G I G G F L T P V I G R </s> C C O P ( = O ) ( C O c 1 c c c ( C [ C @ H ] ( N C ( = O ) O [ C @ H ] 2 C O [ C @ H ] 3 O C C [ C @ H ] 3 2 ) [ C @ H ] ( O ) C N ( C C ( C ) C ) S ( = O ) ( = O ) c 2 c c c ( O C ) c c 2 ) c c 1 ) O C C
11.64
E G R E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P G N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S Y F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L S </s> Q Y V D T L Y F E G T E M W N W Y G G G F Y S G A L V Y Y E S A G A Q S W V D H E W H V L Q E S I F R F S E S Y F V Y G I L W M P H G Y E I </s> N c 1 c c c 2 c ( c 1 ) [ C @ H ] ( c 1 c c c c c 1 ) N ( C C C C C c 1 c n n n 1 C C N c 1 c 3 c ( n c 4 c c c c c 1 4 ) C C C C 3 ) c 1 c c ( N ) c c c 1 - 2
11.68
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G M T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G M T L N F </s> R L D T G A D D T V K I G G I G L T P V I G L D T G A D D T V K I G G I G G F L T P V I G R </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c ( O C [ P + ] ( = O ) ( = O ) [ O - ] ) c c 2 ) N C ( = O ) O [ C @ H ] 2 C O [ C @ H ] 3 O C C [ C @ H ] 3 2 ) c c 1
11.68
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F </s> R L L D T G A D D T V K M I G G I G G F I V L P T P V N I I G R N R L L D T G A D D T V K M I G G I G G F I V L T P V N I I G R N </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( B ( [ O H 2 + ] ) [ O H 2 + ] ) c c 1
11.7
F S M K I G I I G A M E E E V T L L R D K I E N R Q T I S L G G C E I Y T G Q L N G T E V A L L K S G I G K V A A A L G A T L L L E H C K P D V I I N T G S A G G L A P T L K V G D I V V S D E A R Y H D A D V T A F G Y E Y G Q L P G C P A G F K A D D K L I A A A E A C I A E L N L N A V R G L I V S G D A F I N G S V G L A K I R H N F P Q A I A V E M E A T A I A H V C H N F N V P F V V V R A I S D V A D Q Q S H L S F D E F L A V A A K Q S S L M V E S L V Q K L A H G M K I G I I G A M E E E V T L L R D K I E N R Q T I S L G G C E I Y T G Q L N G T E V A L L K S G I G K V A A A L G A T L L L E H C K P D V I I N T G S A G G L A P T L K V G D I V V S D E A R Y H D A D V T A F G Y E Y G Q L P G C P A G F K A D D K L I A A A E A C I A E L N L N A V R G L I V S G D A F I N G S V G L A K I R H N F P Q A I A V E M E A T A I A H V C H N F N V P F V V V R A I S D V A D Q Q S H L S F D E F L A V A A K Q S S L M V E S L V Q K L A H G </s> A M E G I G G S A G G H G A F I N V E M E R A S D V A D S H F L V F Y P </s> C S C [ C @ H ] 1 C [ N @ @ H + ] ( C c 2 c [ n H ] c 3 c ( N ) n c n c 2 3 ) C [ C @ @ H ] 1 O
11.7
A D P D P M K N T C K L L V V A D H R F Y R Y M G R G E E S T T T N Y L I E L I D R V D D I Y R N T A W D N A G F K G Y G I Q I E Q I R I L K S P Q E V K P G E K H Y N M A K S Y P N E E K D A W D V K M L L E Q F S F D I A E E A S K V C L A H L F T Y Q D F D M G T L G L A Y G G S P R A N S H G G V C P K A Y Y S P V G K K N I Y L N S G L T S T K N Y G K T I L T K E A D L V T T H E L G H N F G A E H D P D G L A E C A P N E D Q G G K Y V M Y P I A V S G D H E N N K M F S Q C S K Q S I Y K T I E S K A Q E C F Q E R S N A </s> V K L H F D M G T L G L A Y G G S G L T S N Y I L T K E A D L V T T H E L G H N A E H D E G G K Y V M Y P I A V S G D H N N K M </s> C c 1 c c ( C O c 2 c c c ( [ C @ ] 3 ( C ) C C N ( [ C @ H ] ( C ) C ( = O ) N O ) C 3 = O ) c c 2 ) c 2 c c c c c 2 n 1
11.7
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L M T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L M T Q I G C T L N F </s> L D T G A D D T V I G G I G L T P V I G R R L D T G A D D T V K I G G I G L T P V I G </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( N ) c c 1
11.7
P D W G Y D D K N G P E Q W S K L Y P I A N G N N Q S P V D I K T S E T K H D T S L K P I S V S Y N P A T A K E I I N V G H S F H V N F E D N D N R S V L K G G P F S D S Y R L F Q F H F H W G S T N E H G S E H T V D G V K Y S A E L H V A H W N S A K Y S S L A E A A S K A D G L A V I G V L M K V G E A N P K L Q K V L D A L Q A I K T K G K R A P F T N F D P S T L L P S S L D F W T Y P G S L T H P P L Y E S V T W I I C K E S I S V S S E Q L A Q F R S L L S N V E G D N A V P M Q H N N R P T Q P L K G R T V R A S F </s> W Y W S P H S H N F Q F H F H E H E L H V A H L A A A S L A V I G G S L T H P P L Y S V W N R </s> C C C S c 1 c ( F ) c ( F ) c ( S ( N ) ( = O ) = O ) c ( F ) c 1 F
11.7
L E L R L K S P V G A E P A V Y P W P L P V Y D K H H D A A H E I I E T I R W V C E E I P D L K L A M E N Y V L I D Y D T K S F E S M Q R L C D K Y N R A I D S I H Q L W K G N T R P S T G L L R H I L Q Q V Y N H S V T D P E K G E T S F D L V A Q M I D E I K M T D D D L F V D L G S G V G Q V V L Q V A A A T N C K H H Y G V E K A D I P A K Y A E T M D R E F R K W M K W Y G K K H A E Y T L E R G D F L S E E W R E R I A N T S V I F V N N F A F G P E V D H Q L K E R F A N M K E G G R I V S S K P F A P L N F R I N S R N L S D I G T I M R V V E L S P L K S W T G K P V S Y Y L H T I D R T I L E N Y F S S L K N </s> G E T S F D L V A Q M F V D L G S G V G Q V V L Q G V E K A D I P A E R G D F L S W I F V N N F A F G E V D Q L R I V S S K L K V S Y Y </s> C c 1 n c c c c 1 - c 1 c ( C l ) s c 2 c c c ( N C ( = O ) N C C ( = O ) N C C C [ N @ H + ] ( C ) [ C @ @ H ] 3 C C C N ( c 4 n c n c 5 [ n H ] c c c 4 5 ) C 3 ) c c 1 2
11.72
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N V I G R N L M T Q I G M T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N V I G R N L M T Q I G M T L N F </s> R L D T G A D D T V K I G G I G L T P V V G R L D T G A D D T V I G G I G G F L T P V V G R </s> C C O P ( = O ) ( C O c 1 c c c ( C [ C @ H ] ( N C ( = O ) O [ C @ H ] 2 C O [ C @ H ] 3 O C C [ C @ H ] 3 2 ) [ C @ H ] ( O ) C N ( C C ( C ) C ) S ( = O ) ( = O ) c 2 c c c ( O C ) c c 2 ) c c 1 ) O C C
11.74
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F </s> R L D T G A D D T V K M I G G I G L T P V I G R L D T G A D D T V M I G G I G F L T P V I </s> C O C ( = O ) N [ C @ @ H ] 1 C O [ C @ @ H ] 2 C [ C @ H ] ( O C ( = O ) N [ C @ @ H ] ( C c 3 c c c c c 3 ) [ C @ H ] ( O ) C N ( C C ( C ) C ) S ( = O ) ( = O ) c 3 c c c ( O C ) c c 3 ) C [ C @ H ] 1 2
11.85
D C G L R P L F E K K S L E D K T E R L S Y I I V E G S D A E I G M S P W Q V M L F R K S P Q E L L C G A S L I S D R W V L T A A H C L L Y P W D K N F T E N D L L V R I G K H S R T R Y E R N I E K I S M L E K I Y I H P R Y N W R E N L D R D I A L M K L K K P V A F S D Y I H P V C L P D R E T A S L L Q A G Y K G R V T G W G N L K E G Q P S V L Q V V N L P I V E R P V C K D S T R I R I T D N M F C A G Y K P D E G K R G D A C E G D S G G P F V M K S P F N N R W Y Q M G I V S W G E G C D R D G K Y G F Y T H V F R L K K W I Q K V I D Q F G D F E E I P E E L A </s> H Y W K Y N W R E N L D E T I D A C E G D S I V S W G E G C D Y G F Y </s> O = C ( C n 1 c ( C l ) c n c ( N C C ( F ) ( F ) c 2 c c c c [ n + ] 2 [ O - ] ) c 1 = O ) N C c 1 c c ( C l ) c c c 1 - n 1 c n n n 1
11.89
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L D T G A D D T V K M I G G I G G F I V L P T P V N I I G R N R P L L D T G A D D T V L K M I G G I G G I V L P T P V N I I G R N </s> C c 1 c c c c ( C ) c 1 O C C ( = O ) N [ C @ @ H ] ( C c 1 c c c c c 1 ) [ C @ @ H ] ( O ) C [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) [ C @ H ] ( C ( C ) C ) N 1 C C C N C 1 = O
11.89
P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W Q R P L V T I K I G G Q L K E A L L D T G A D D T V L E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I L I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V M I G G I G L T P V I G R R L D T G A D D T V I G G I G L T P V I G </s> C c 1 c c c c ( C ) c 1 O C C ( = O ) N [ C @ @ H ] ( C c 1 c c c c c 1 ) [ C @ @ H ] ( O ) C [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) [ C @ H ] ( C ( C ) C ) N 1 C C C N C 1 = O
12
A T L D S W L S N E A T V A R T A I L N N I G A D G A W V S G A D S G I V V A S P S T D N P D Y F Y T W T R D S G L V I K T L V D L F R N G D T D L L S T I E H Y I S S Q A I I Q G V S N P S G D L S S G G L G E P K F N V D E T A Y T G S W G R P Q R D G P A L R A T A M I G F G Q W L L D N G Y T S A A T E I V W P L V R N D L S Y V A Q Y W N Q T G Y D L W E E V N G S S F F T I A V Q H R A L V E G S A F A T A V G S S C S W C D S Q A P Q I L C Y L Q S F W T G S Y I L A N F D S S R S G K D T N T L L G S I H T F D P E A G C D D S T F Q P C S P R A L A N H K E V V D S F R S I Y T L N D G L S D S E A V A V G R Y P E D S Y Y N G N P W F L C T L A A A E Q L Y D A L Y Q W D K Q G S L E I T D V S L D F F K A L Y S G A A T G T Y S S S S S T Y S S I V S A V K T F A D G F V S I V E T H A A S N G S L S E Q F D K S D G D E L S A R D L T W S Y A A L L T A N N R R N S V V P P S W G E T S A S S V P G T C A A T S A S G T Y S S V T V T S W P S I V A </s> V A S P D Y Y T W T R D S L P K Y G S W G R Q D Y D L W E E V N F R L R Y D S Y Y W L E Q S A L T W S </s> C [ C @ H ] 1 O [ C @ H ] ( O [ C @ H ] 2 [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ @ H ] ( O [ C @ H ] 3 [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ H ] ( O ) O [ C @ @ H ] 3 C O ) O [ C @ @ H ] 2 C O ) [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ @ H ] 1 [ N H 2 + ] [ C @ H ] 1 C = C ( C O ) [ C @ @ H ] ( O ) [ C @ H ] ( O ) [ C @ H ] 1 O
12
A T L D S W L S N E A T V A R T A I L N N I G A D G A W V S G A D S G I V V A S P S T D N P D Y F Y T W T R D S G L V I K T L V D L F R N G D T D L L S T I E H Y I S S Q A I I Q G V S N P S G D L S S G G L G E P K F N V D E T A Y T G S W G R P Q R D G P A L R A T A M I G F G Q W L L D N G Y T S A A T E I V W P L V R N D L S Y V A Q Y W N Q T G Y D L W E E V N G S S F F T I A V Q H R A L V E G S A F A T A V G S S C S W C D S Q A P Q I L C Y L Q S F W T G S Y I L A N F D S S R S G K D T N T L L G S I H T F D P E A G C D D S T F Q P C S P R A L A N H K E V V D S F R S I Y T L N D G L S D S E A V A V G R Y P E D S Y Y N G N P W F L C T L A A A E Q L Y D A L Y Q W D K Q G S L E I T D V S L D F F K A L Y S G A A T G T Y S S S S S T Y S S I V S A V K T F A D G F V S I V E T H A A S N G S L S E Q F D K S D G D E L S A R D L T W S Y A A L L T A N N R R N S V V P P S W G E T S A S S V P G T C A A T S A S G T Y S S V T V T S W P S I V A T </s> V A S P D Y Y T W T R D S L P K Y S W G R Q D Y D L W E E V N F R L R Y D S Y Y W L E Q S A L T W S </s> C [ C @ H ] 1 O [ C @ H ] ( O [ C @ H ] 2 [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ @ H ] ( O [ C @ H ] 3 [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ @ H ] ( O ) O [ C @ @ H ] 3 C O ) O [ C @ @ H ] 2 C O ) [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ @ H ] 1 [ N H 2 + ] [ C @ H ] 1 C = C ( C O ) [ C @ @ H ] ( O ) [ C @ H ] ( O ) [ C @ H ] 1 O
12
S I K I D R F N N I S A V N G P G E E D T W A S A Q K Q G V G T A N N Y V S K V W F T L A N G A I S E V Y Y P T I D T A D V K E I K F I V T D G K S F V P D E T K D A I S K V E K F T D K S L G Y K L V N T D K K G R Y R I T K D I F T D V K R N S L I M K A K F E A L E G S I H D Y K L Y L A Y D P H I K N Q G S Y N E G Y V I K A N N N E M L M A K R D N V Y T A L S S N I G W K G Y S I G Y Y K V N D I M T D L D E N K Q M T K H Y D S A R G N I I E G A E I D L T K N S E F E I V L S F G Q S D S E A A K T A L E T L G E D Y N N L K N N Y I D E W T K Y C N T L N N F N G K A N S L Y Y N S M M I L K A S E D K T N K G A Y I A S L S I P W G D G Q R D D N T G G Y H L V W S R D L Y H V A N A F I A A G D V D S A N R S L D Y L A K V V K D N G M I P Q N T W I S G K P Y W T G I Q L D E Q A D P I I L S Y R L K R Y D L Y D S L V K P L A D F I I K I G P K T G Q E R W E E I G G Y S P A T M A A E V A G L T C A A Y I A E Q N K D Y E S A Q K Y Q E K A D N W Q K L I D N L T Y T E N G P L G N G Q Y Y I R I A G L S D P D A D F M I N I A N G G G V Y D Q K E I V D P S F L E L V R L G V K S A D D P K I L N T L K V V D S T I K V D T P K G P S W Y R Y N H D G Y G E P S K T E L Y H G A G K G R L W P L L T G E R G M Y E I A A G K D A T P Y V K A M E K F A N E G G I I S E Q V W E D T G L P T D S A S P L N W A H A E Y V I L F A S N I E H K V L D M P D I V Y K R Y V A </s> I A S P W G Y L V W S R D L H Q N Y W T G I Q D E Q E R W E E I R I A N G S R Y D G Y G Y H G W L L E Q A P L N W A </s> C [ C @ H ] 1 O [ C @ H ] ( O [ C @ H ] 2 [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ @ H ] ( O [ C @ H ] 3 [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ @ H ] ( O ) O [ C @ @ H ] 3 C O ) O [ C @ @ H ] 2 C O ) [ C @ H ] ( O ) [ C @ @ H ] ( O ) [ C @ @ H ] 1 [ N H 2 + ] [ C @ H ] 1 C = C ( C O ) [ C @ @ H ] ( O ) [ C @ H ] ( O ) [ C @ H ] 1 O
12
G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A F K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A F K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A F K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A F K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K </s> Y N Q L G S T F Y E S A V G N A E Y W V A F K R N A H S A T T W T Q W L L T S G L V G H D T F W K </s> O = C ( [ O - ] ) C C C C [ C @ @ H ] 1 S C [ C @ @ H ] 2 N C ( = O ) N [ C @ @ H ] 2 1
12
G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q F L L T S G T T E A N A W K S T L V G H D T F T K V K P G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q F L L T S G T T E A N A W K S T L V G H D T F T K V G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q F L L T S G T T E A N A W K S T L V G H D T F T K V G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q F L L T S G T T E A N A W K S T L V G H D T F T K V </s> N Q L G S T F Y E S A V G N A E Y W V A W K R N A H S A T T W T Q F L L T S G L V G H D T F W K </s> O = C ( [ O - ] ) C C C C [ C @ @ H ] 1 S C [ C @ @ H ] 2 N C ( = O ) N [ C @ @ H ] 2 1
12
G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q F L L T S G T T E A N A W K S T L V G H D T F T K V K P G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q F L L T S G T T E A N A W K S T L V G H D T F T K V G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q F L L T S G T T E A N A W K S T L V G H D T F T K V G I T G T W Y N Q L G S T F I V T A G A D G A L T G T Y E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q F L L T S G T T E A N A W K S T L V G H D T F T K V </s> N Q L G S T Y E S A V G N A W A H S A T W F L S D F W </s> O = C ( [ O - ] ) C C C C [ C @ @ H ] 1 S C [ C @ @ H ] 2 N C ( = O ) N [ C @ @ H ] 2 1
12
E P L E S Q Y Q V G P L L G S G G F G S V Y S G I R V S D N L P V A I K H V E K D R I S D W G E L P N G T R V P M E V V L L K K V S S G F S G V I R L L D W F E R P D S F V L I L E R P E P V Q D L F D F I T E R G A L Q E E L A R S F F W Q V L E A V R H C H N C G V L H R D I K D E N I L I D L N R G E L K L I D F G S G A L L K D T V Y T D F D G T R V Y S P P E W I R Y H R Y H G R S A A V W S L G I L L Y D M V C G D I P F E H D E E I I R G Q V F F R Q R V S E C Q H L I R W C L A L R P S D R P T F E E I Q N H P W M Q D V L L P Q E T A E I H L H S </s> L L G S G G F G S V Y S G P V A I K H V E L I R L L I L E R P E P V Q D L F D H D K D E N I L I D L K L I D F G S </s> C [ C @ H ] 1 C N ( c 2 c c n c c 2 N C ( = O ) c 2 c c c ( F ) c ( - c 3 c ( F ) c c c c 3 F ) n 2 ) C [ C @ @ H ] ( [ N H 3 + ] ) [ C @ @ H ] 1 O
12
E P L E S Q Y Q V G P L L G S G G F G S V Y S G I R V S D N L P V A I K H V E K D R I S D W G E L P N G T R V P M E V V L L K K V S S G F S G V I R L L D W F E R P D S F V L I L E R P E P V Q D L F D F I T E R G A L Q E E L A R S F F W Q V L E A V R H C H N C G V L H R D I K D E N I L I D L N R G E L K L I D F G S G A L L K D T V Y T D F D G T R V Y S P P E W I R Y H R Y H G R S A A V W S L G I L L Y D M V C G D I P F E H D E E I I R G Q V F F R Q R V S E C Q H L I R W C L A L R P S D R P T F E E I Q N H P W M Q D V L L P Q E T A E I H L H S </s> L G S F G V Y S V A K E I L E R P V Q D L F D D E N I L I I D F G </s> C [ C @ H ] 1 C N ( c 2 c c n c c 2 N C ( = O ) c 2 c c c ( F ) c ( - c 3 c ( F ) c c c c 3 F ) n 2 ) C [ C @ @ H ] ( [ N H 3 + ] ) [ C @ @ H ] 1 O
12
V Q L V Q S G A E V K K P G A S V K V S C K A S G Y T F T S Y A I H W V R Q A P G Q R L E W M G W I K A G N G N T R Y S Q K F Q D R V T I T R D T S T T T A Y M E L S S L R S E D T A V Y Y C A L L T V L T P D D A F D I W G Q G T M V T V S S A S T K G P S V F P L A P S S K S T S G G T A A L G C L V K D Y F P E P V T V S W N S G A L T S G V H T F P A V L Q S S G L Y S L S S V V T V P S S S L G T Q T Y I C N V N H K P S N T K V D K K V E P D I V M T Q S P D S L A V S L G E R A T I N C K S S Q S V L Y S S N N K N Y L A W Y Q Q K P G Q P P N L L I Y W A S T R Q S G V P D R F S G S G S G T D F T L T I S S L Q A E D V A V Y Y C H Q Y Y S S P L T F G G G T K V E I K R T V A A P S V F I F P P S D E Q L K S G T A S V V C L L N N F Y P R E A K V Q W K V D N A L Q S G N S Q E S V T E Q D S K D S T Y S L S S T L T L S K A D Y E K H K V Y A C E V T H Q G L S S P V T K S F N R </s> Y F S Y A I H W G W I K A N T R A L L T V L T P D D A F D I I Q S V L Y S S N N K Y Y Y W H Q Y Y S S P L T </s> C C ( C ) [ C @ H ] ( N C ( = O ) [ C @ H ] ( C C ( N ) = O ) N C ( = O ) [ C @ @ H ] 1 C C C N 1 C ( = O ) [ C @ H ] ( C C ( N ) = O ) N C ( = O ) [ C @ H ] ( C ) N C ( = O ) [ C @ H ] ( C C ( N ) = O ) N C ( = O ) [ C @ @ H ] 1 C C C N 1 C ( = O ) [ C @ H ] ( C C ( = O ) [ O - ] ) N C ( = O ) [ C @ @ H ] 1 C C C N 1 C ( = O ) [ C @ @ H ] ( [ N H 3 + ] ) C C ( N ) = O ) C ( = O ) N [ C @ @ H ] ( C C ( = O ) [ O - ] ) C ( = O ) N 1 C C C [ C @ H ] 1 C ( = O ) N [ C @ @ H ] ( C C ( N ) = O ) C ( = O ) [ O - ]
12.05
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L L D T G A D D T V I G G I G G F I V L T P V N I I G R N R P L L L D T G A D D T V K M I G G I G G F I V L T P V N I I G R N </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c 2 c ( c 1 ) O C O 2
12.05
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V I G G I G L T P V I G R R L D T G A D D T V K M I G G I G L T P V I G </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c 2 c ( c 1 ) O C O 2
12.1
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L L D T G A D D T V I G G I G G F I L T P V N I I G R R P L L L D T G A D D T V K M I G G I G G F I V L P T P V N I I G R N </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) [ C @ @ H ] 2 C N ( c 3 c c c c ( C ( C ) = O ) c 3 ) C ( = O ) O 2 ) c c 1
12.1
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D I G G I G G F T P V N I R R L D T G A D D T V K M I G G I G L T P V I G </s> C O c 1 c c c ( S ( = O ) ( = O ) N ( C C ( C ) C ) C [ C @ @ H ] ( O ) [ C @ H ] ( C c 2 c c c c c 2 ) N C ( = O ) [ C @ @ H ] 2 C N ( c 3 c c c c ( C ( C ) = O ) c 3 ) C ( = O ) O 2 ) c c 1
12.1
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L L D T G A D D T V I G G I G G F I V L P T P V N I I G R N R P L L L D T G A D D T V K M I G G I G G F I V L T P V N I I G R N </s> C C C ( C C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c 2 c ( c 1 ) O C O 2
12.1
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L D T G A D D T V I G G I G L T P V I G R R L D T G A D D T V K M I G G I G L T P V I G </s> C C C ( C C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c 2 c ( c 1 ) O C O 2
12.16
G I T G T W Y N Q L G S T F I V T A G A D G A L T G T F E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T F E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T F E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T F E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K </s> N Q L G S T F F E S A V G N A E Y W V A W K R N A H S A T T W T W L L T S G L V G H D F W K </s> O = C ( [ O - ] ) C C C C [ C @ @ H ] 1 S C [ C @ @ H ] 2 N C ( = O ) N [ C @ @ H ] 2 1
12.16
G I T G T W Y N Q L G S T F I V T A G A D G A L T G T F E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T F E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T F E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K G I T G T W Y N Q L G S T F I V T A G A D G A L T G T F E S A V G N A E S R Y V L T G R Y D S A P A T D G S G T A L G W T V A W K N N Y R N A H S A T T W S G Q Y V G G A E A R I N T Q W L L T S G T T E A N A W K S T L V G H D T F T K </s> N Q L S T F E S A V G N A Y W A H S A T W W L L S D F W </s> O = C ( [ O - ] ) C C C C [ C @ @ H ] 1 S C [ C @ @ H ] 2 N C ( = O ) N [ C @ @ H ] 2 1
12.3
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L L D T G A D D T V I G G I G G I V L T P V N I I G R N R P L L L D T G A D D T V K M I G G I G G F I V L T P V N I I G R N </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( C O ) c c 1
12.3
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> L D T G A D D T V I G G I G L T P V I G R R L D T G A D D T V K I G G I G L T P V I </s> C C [ C @ H ] ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( C O ) c c 1
12.3
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> R L L L D T G A D D T V I G G I G G F I V L P T P V N I I G R N R P L L L D T G A D D T V K M I G G I G G F I V T L T P V N I I G R N </s> C C C ( C C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( C O ) c c 1
12.3
P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F P Q I T L W K R P L V T I R I G G Q L K E A L L D T G A D D T V L E E M N L P G K W K P K M I G G I G G F I K V R Q Y D Q I P I E I C G H K A I G T V L V G P T P V N I I G R N L L T Q I G C T L N F </s> L D T G A D D T V I G G I G L T P V I G R R L D T G A D D T V K I G G I G L T P V I </s> C C C ( C C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( C O ) c c 1
12.3
P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F P Q I T L W K R P L V T I K I G G Q L K E A L L D T G A D D T V I E E M S L P G R W K P K M I G G I G G F I K V R Q Y D Q I I I E I A G H K A I G T V L V G P T P V N I I G R N L L T Q I G A T L N F </s> R L L D T G A D D T V K M I G G I G G F I V L T P V N I I G R N R L L D T G A D D T V K M I G G I G G F I L T P V N I I G R N </s> C C ( C ) C N ( C [ C @ @ H ] ( O ) [ C @ H ] ( C c 1 c c c c c 1 ) N C ( = O ) O [ C @ H ] 1 C O [ C @ H ] 2 O C C [ C @ H ] 2 1 ) S ( = O ) ( = O ) c 1 c c c ( B ( O ) O ) c c 1
12.33
R Y K P D W E S L R E H T V P K W F D K A K F G I F I H W G I Y S V P G W A T P T G E L G K V P M D A W F F Q N P Y A E W Y E N S L R I K E S P T W E Y H V K T Y G E N F E Y E K F A D L F T A E K W D P Q E W A D L F K K A G A K Y V I P T T K H H D G F C L W G T K Y T D F N S V K R G P K R D L V G D L A K A V R E A G L R F G V Y Y S G G L D W R F T T E P I R Y P E D L S Y I R P N T Y E Y A D Y A Y K Q V M E L V D L Y L P D V L W N D M G W P E K G K E D L K Y L F A Y Y Y N K H P E G S V N D R W G V P H W D F K T A E Y H V N Y P G D L P G Y K W E F T R G I G L S F G Y N R N E G P E H M L S V E Q L V Y T L V D V V S K G G N L L L N V G P K G D G T I P D L Q K E R L L G L G E W L R K Y G D A I Y G T S V W E R C C A K T E D G T E I R F T R K C N R I F V I F L G I P T G E K I V I E D L N L S A G T V R H F L T G E R L S F K N V G K N L E I T V P K K L L E T D S I T L V L E A V R Y K P D W E S L R E H T V P K W F D K A K F G I F I H W G I Y S V P G W A T P T G E L G K V P M D A W F F Q N P Y A E W Y E N S L R I K E S P T W E Y H V K T Y G E N F E Y E K F A D L F T A E K W D P Q E W A D L F K K A G A K Y V I P T T K H H D G F C L W G T K Y T D F N S V K R G P K R D L V G D L A K A V R E A G L R F G V Y Y S G G L D W R F T T E P I R Y P E D L S Y I R P N T Y E Y A D Y A Y K Q V M E L V D L Y L P D V L W N D M G W P E K G K E D L K Y L F A Y Y Y N K H P E G S V N D R W G V P H W D F K T A E Y H V N Y P G D L P G Y K W E F T R G I G L S F G Y N R N E G P E H M L S V E Q L V Y T L V D V V S K G G N L L L N V G P K G D G T I P D L Q K E R L L G L G E W L R K Y G D A I Y G T S V W E R C C A K T E D G T E I R F T R K C N R I F V I F L G I P T G E K I V I E D L N L S A G T V R H F L T G E R L S F K N V G K N L E I T V P K K L L E T D S I T L V L E A V R Y K P D W E S L R E H T V P K W F D K A K F G I F I H W G I Y S V P G W A T P T G E L G K V P M D A W F F Q N P Y A E W Y E N S L R I K E S P T W E Y H V K T Y G E N F E Y E K F A D L F T A E K W D P Q E W A D L F K K A G A K Y V I P T T K H H D G F C L W G T K Y T D F N S V K R G P K R D L V G D L A K A V R E A G L R F G V Y Y S G G L D W R F T T E P I R Y P E D L S Y I R P N T Y E Y A D Y A Y K Q V M E L V D L Y L P D V L W N D M G W P E K G K E D L K Y L F A Y Y Y N K H P E G S V N D R W G V P H W D F K T A E Y H V N Y P G D L P G Y K W E F T R G I G L S F G Y N R N E G P E H M L S V E Q L V Y T L V D V V S K G G N L L L N V G P K G D G T I P D L Q K E R L L G L G E W L R K Y G D A I Y G T S V W E R C C A K T E D G T E I R F T R K C N R I F V I F L G I P T G E K I V I E D L N L S A G T V R H F L T G E R L S F K N V G K N L E I T V P K K L L E T D S I T L V L E A V R Y K P D W E S L R E H T V P K W F D K A K F G I F I H W G I Y S V P G W A T P T G E L G K V P M D A W F F Q N P Y A E W Y E N S L R I K E S P T W E Y H V K T Y G E N F E Y E K F A D L F T A E K W D P Q E W A D L F K K A G A K Y V I P T T K H H D G F C L W G T K Y T D F N S V K R G P K R D L V G D L A K A V R E A G L R F G V Y Y S G G L D W R F T T E P I R Y P E D L S Y I R P N T Y E Y A D Y A Y K Q V M E L V D L Y L P D V L W N D M G W P E K G K E D L K Y L F A Y Y Y N K H P E G S V N D R W G V P H W D F K T A E Y H V N Y P G D L P G Y K W E F T R G I G L S F G Y N R N E G P E H M L S V E Q L V Y T L V D V V S K G G N L L L N V G P K G D G T I P D L Q K E R L L G L G E W L R K Y G D A I Y G T S V W E R C C A K T E D G T E I R F T R K C N R I F V I F L G I P T G E K I V I E D L N L S A G T V R H F L T G E R L S F K N V G K N L E I T V P K K L L E T D S I T L V L E A V R Y K P D W E S L R E H T V P K W F D K A K F G I F I H W G I Y S V P G W A T P T G E L G K V P M D A W F F Q N P Y A E W Y E N S L R I K E S P T W E Y H V K T Y G E N F E Y E K F A D L F T A E K W D P Q E W A D L F K K A G A K Y V I P T T K H H D G F C L W G T K Y T D F N S V K R G P K R D L V G D L A K A V R E A G L R F G V Y Y S G G L D W R F T T E P I R Y P E D L S Y I R P N T Y E Y A D Y A Y K Q V M E L V D L Y L P D V L W N D M G W P E K G K E D L K Y L F A Y Y Y N K H P E G S V N D R W G V P H W D F K T A E Y H V N Y P G D L P G Y K W E F T R G I G L S F G Y N R N E G P E H M L S V E Q L V Y T L V D V V S K G G N L L L N V G P K G D G T I P D L Q K E R L L G L G E W L R K Y G D A I Y G T S V W E R C C A K T E D G T E I R F T R K C N R I F V I F L G I P T G E K I V I E D L N L S A G T V R H F L T G E R L S F K N V G K N L E I T V P K K L L E T D S I T L V L E A V R Y K P D W E S L R E H T V P K W F D K A K F G I F I H W G I Y S V P G W A T P T G E L G K V P M D A W F F Q N P Y A E W Y E N S L R I K E S P T W E Y H V K T Y G E N F E Y E K F A D L F T A E K W D P Q E W A D L F K K A G A K Y V I P T T K H H D G F C L W G T K Y T D F N S V K R G P K R D L V G D L A K A V R E A G L R F G V Y Y S G G L D W R F T T E P I R Y P E D L S Y I R P N T Y E Y A D Y A Y K Q V M E L V D L Y L P D V L W N D M G W P E K G K E D L K Y L F A Y Y Y N K H P E G S V N D R W G V P H W D F K T A E Y H V N Y P G D L P G Y K W E F T R G I G L S F G Y N R N E G P E H M L S V E Q L V Y T L V D V V S K G G N L L L N V G P K G D G T I P D L Q K E R L L G L G E W L R K Y G D A I Y G T S V W E R C C A K T E D G T E I R F T R K C N R I F V I F L G I P T G E K I V I E D L N L S A G T V R H F L T G E R L S F K N V G K N L E I T V P K K L L E T D S I T L V L E A V </s> F I H Y L G M W F N P Y A E W Y T K H H D Y S G L W I Y P L R W N D M G R T A E Y V N T R G S F G L N </s> C [ C @ @ H ] 1 [ N H 2 + ] [ C @ H ] ( C N C ( = O ) C C c 2 c [ n H ] c 3 c c c c c 2 3 ) [ C @ @ H ] ( O ) [ C @ H ] ( O ) [ C @ @ H ] 1 O
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R Y K P D W E S L R E H T V P K W F D K A K F G I F I H W G I Y S V P G W A T P T G E L G K V P M D A W F F Q N P Y A E W Y E N S L R I K E S P T W E Y H V K T Y G E N F E Y E K F A D L F T A E K W D P Q E W A D L F K K A G A K Y V I P T T K H H D G F C L W G T K Y T D F N S V K R G P K R D L V G D L A K A V R E A G L R F G V Y Y S G G L D W R F T T E P I R Y P E D L S Y I R P N T Y E Y A D Y A Y K Q V M E L V D L Y L P D V L W N D M G W P E K G K E D L K Y L F A Y Y Y N K H P E G S V N D R W G V P H W D F K T A E Y H V N Y P G D L P G Y K W E F T R G I G L S F G Y N R N E G P E H M L S V E Q L V Y T L V D V V S K G G N L L L N V G P K G D G T I P D L Q K E R L L G L G E W L R K Y G D A I Y G T S V W E R C C A K T E D G T E I R F T R K C N R I F V I F L G I P T G E K I V I E D L N L S A G T V R H F L T G E R L S F K N V G K N L E I T V P K K L L E T D S I T L V L E A V </s> F H L M W F N Y E W T H H Y L P L W D M G R E V N T F </s> C [ C @ @ H ] 1 [ N H 2 + ] [ C @ H ] ( C N C ( = O ) C C c 2 c [ n H ] c 3 c c c c c 2 3 ) [ C @ @ H ] ( O ) [ C @ H ] ( O ) [ C @ @ H ] 1 O
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E G R E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P G N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S Y F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L S E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S Y F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L </s> Q Y V D T L Y F E G T E M W N P W I Y G G G F Y S G A L V Y Y G T E S A G A Q S W Q L V D H E W H V L S I F R F S F V E S Y F L V Y G V L W M P H G Y E I </s> N c 1 c c c 2 c ( c 1 ) c ( - c 1 c c c c c 1 ) [ n + ] ( C C C C C C c 1 c n n n 1 C C N c 1 c 3 c ( n c 4 c c c c c 1 4 ) C C C C 3 ) c 1 c c ( N ) c c c 2 1
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E G R E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P G N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S Y F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L S E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S Y F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L </s> Y D L G T W N Y G G G F Y S G L Y E S A V D H E W H S I F R F S Y F V Y G W M P H G Y I </s> N c 1 c c c 2 c ( c 1 ) c ( - c 1 c c c c c 1 ) [ n + ] ( C C C C C C c 1 c n n n 1 C C N C 1 = C 3 C = C C C = C 3 N c 3 c c c c c 3 1 ) c 1 c c ( N ) c c c 2 1
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E G R E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P P N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S A F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L S A T </s> Q Y V D T L Y P F E G T E M W N P W Y G G G F Y S G A L V Y Y E S A G A Q S W V E W L Q E S I F R F S V E S A F L V Y G V I P L W M P H G Y E I </s> N c 1 c c c 2 c ( c 1 ) C ( c 1 c c c c c 1 ) N ( C C C C C C c 1 c n n n 1 C C N c 1 c 3 c c c c c 3 n c 3 c c c c c 1 3 ) c 1 c c ( N ) c c c 1 - 2
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E G R E D P Q L L V R V R G G Q L R G I R L K A P G G P V S A F L G I P F A E P P V G S R R F M P P E P K R P W S G V L D A T T F Q N V C Y Q Y V D T L Y P G F E G T E M W N P N R E L S E D C L Y L N V W T P Y P R P A S P T P V L I W I Y G G G F Y S G A A S L D V Y D G R F L A Q V E G A V L V S M N Y R V G T F G F L A L P G S R E A P G N V G L L D Q R L A L Q W V Q E N I A A F G G D P M S V T L F G E S A G A A S V G M H I L S L P S R S L F H R A V L Q S G T P N G P W A T V S A G E A R R R A T L L A R L V G C P P N D T E L I A C L R T R P A Q D L V D H E W H V L P Q E S I F R F S F V P V V D G D F L S D T P E A L I N T G D F Q D L Q V L V G V V K D E G S A F L V Y G V P G F S K D N E S L I S R A Q F L A G V R I G V P Q A S D L A A E A V V L H Y T D W L H P E D P T H L R D A M S A V V G D H N V V C P V A Q L A G R L A A Q G A R V Y A Y I F E H R A S T L T W P L W M G V P H G Y E I E F I F G L P L D P S L N Y T T E E R I F A Q R L M K Y W T N F A R T G D P N D P R D S K S P Q W P P Y T T A A Q Q Y V S L N L K P L E V R R G L R A Q T C A F W N R F L P K L L S A T </s> Y V D T L G T W N Y G G G F Y S G L Y E S A W L Q E S I F R F A F V Y G V I W P H G Y I </s> N c 1 c c c 2 c ( c 1 ) c ( - c 1 c c c c c 1 ) [ n + ] ( C C C C C C c 1 c n n n 1 C C N c 1 c 3 c c c c c 3 n c 3 c c c c c 1 3 ) c 1 c c ( N ) c c c 2 1