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38096490 | Catalytic Enantioselective Synthesis of Axially Chiral Imidazoles by Cation-Directed Desymmetrization. | Axially chiral five-membered heterobiaryls synthesized by enantioselective catalysis typically feature large ortho-substituents or a heteroatom in the chiral axis to maintain a stable configuration. Herein we report a cation-directed catalytic enantioselective desymmetrization method that enables rapid access to axially chiral imidazoles with the basic nitrogen at the ortho position and efficiently integrates π-stacking moieties to ensure a stable axial configuration for further applications. The process is operationally simple, is highly enantioselective, and can be performed on the gram scale. The majority of the products are obtained in >90% ee, but interestingly even those with only moderate ee can readily be enriched to near optical purity by selective racemate crystallization. Together with a mild phosphine oxide reduction method, axially chiral imidazoles such as StackPhos and its derivatives are readily prepared in high yield and excellent enantioselectivity on the gram scale. The method also enables the preparation of new chiral non-phosphine-bearing imidazoles. |
38096491 | Exogenous Sucrose Confers Low Light Tolerance in Tomato Plants by Increasing Carbon Partitioning from Stems to Leaves. | Low light (LL) stress adversely affects plant growth and productivity. The role of exogenous sucrose in enhancing plant LL tolerance was investigated by spraying sucrose on tomato (<i>Solanum lycopersicum</i> L.) leaves. This study employed physiological and molecular approaches to identify the underlying mechanisms. Exogenous sucrose activated sucrose hydrolysis-related enzyme activity and upregulated genes encoding sucrose and hexose transporters in mature leaves, decreasing endogenous sucrose levels and promoting sucrose unloading during LL. Stem-related genes associated with sucrose synthesis and transport were also upregulated, enhancing sucrose phloem loading. Furthermore, sucrose from stems activated sucrose unloading in sink leaves, forming a feed-forward loop to sustain sucrose flow during LL. This led to increased nonstructural carbohydrates (NSCs), improved energy metabolism, and enhanced protein synthesis in leaves, ultimately boosting photosynthesis and fruit yield after light recovery. These findings highlight how exogenous sucrose enhances LL tolerance in tomatoes by increasing the transport of NSCs from stems to leaves. |
38096492 | Treatment of Glenoid Wear with the Use of Augmented Glenoid Components in Total Shoulder Arthroplasty: A Scoping Review. | » Treatment of glenoid bone loss continues to be a challenge in total shoulder arthroplasty (TSA). Although correcting glenoid wear to patient's native anatomy is desirable in TSA, there is lack of consensus regarding how much glenoid wear correction is acceptable and necessary in both anatomic and reverse TSA.» Use of augmented glenoid components is a relatively new treatment strategy for addressing moderate-to-severe glenoid wear in TSA. Augmented glenoid components allow for predictable and easy correction of glenoid wear in the coronal and/or axial planes while at the same time maximizing implant seating, improving rotator cuff biomechanics, and preserving glenoid bone stock because of off-axis glenoid reaming.» Augmented glenoid components have distinct advantages over glenoid bone grafting. Glenoid bone grafting is technically demanding, adds to the surgical time, and carries a risk of nonunion and graft resorption with subsequent failure of the glenoid component.» The use of augmented glenoid components in TSA is steadily increasing with easy availability of computed tomography-based preoperative planning software and guidance technology (patient-specific instrumentation and computer navigation).» Although different augment designs (full wedge, half wedge, and step cut) are available and a particular design may provide advantages in specific glenoid wear patterns to minimize bone removal (i.e. a half wedge in B2 glenoids), there is no evidence to demonstrate the superiority of 1 design over others. |
38096493 | Effect of Asymmetry on the Contact Time of Droplet Impact on Superhydrophobic Cylindrical Surfaces. | Reducing the contact time during the droplet impact on the surface is crucial for anti-icing, self-cleaning, and heat transfer optimization applications. This study aims to minimize the contact time by modifying the surface curvature to create an asymmetric impact process. Our experiments showed that the increase in Weber numbers (<i>We</i>) and the decrease in the ratio of surface diameter to droplet diameter (<i>D</i>*) intensify the asymmetry of the impact process, yielding four distinct rebound modes. Low asymmetry observes the liquid retract toward the central point (Rebound Modes 1 and 2), whereas high asymmetry yields a wing-like rebound (Rebound Modes 3 and 4). In Rebound Mode 1, increased asymmetry would lead to more extended contact due to the prolonged waiting period. Conversely, the reduction in contact time in Rebound Mode 2 occurs due to increased asymmetry with no waiting period. For Rebound Modes 3 and 4, the retraction time could be divided into three stages, generated by two liquid detachment modes from the surface. Analysis reveals that an increased asymmetry would reduce the retraction time during the first stage but prolong it during the third stage, with no significant effects on the second. Four correlations, each pertaining to a distinct impact mode, are proposed based on these analyses to describe the contact time concerning <i>We</i> and <i>D</i>* for droplets impacting a superhydrophobic cylindrical surface. |
38096494 | Stroke Hexagon; Protocol for Reduction of Stroke Burden in Resource-Poor Settings. | Stroke is a neurological emergency, with high prevalence, especially in developing countries where it assumes an epidemic proportion. It is globally the second most common cause of death after ischemic heart disease. The poor indices reported in developing countries are multifactorial and related to late case presentation, ignorance, poverty, and unavailability of comprehensive and well-coordinated stroke care. |
38096495 | Shift Current with Gaussian Basis Sets and General Prescription for Maximally Symmetric Summations in the Irreducible Brillouin Zone. | The bulk photovoltaic effect is an experimentally verified phenomenon by which a direct charge current is induced within a non-centrosymmetric material by light illumination. Calculations of its intrinsic contribution, the shift current, are nowadays amenable from first-principles employing plane-wave bases. In this work, we present a general method for evaluating the shift conductivity in the framework of localized Gaussian basis sets that can be employed in both the length and velocity gauges, carrying the idiosyncrasies of the quantum-chemistry approach. The (possibly magnetic) symmetry of the system is exploited in order to fold the reciprocal space summations to the representation domain, allowing us to reduce computation time and unveiling the complete symmetry properties of the conductivity tensor under general light polarization. |
38096496 | Deciphering Lipid Arrangement in Phosphatidylserine/Phosphatidylcholine Mixed Membranes: Simulations and Experiments. | Phosphatidylserine (PS) exposure on the plasma membrane is crucial for many cellular processes including apoptotic cell recognition, blood clotting regulation, cellular signaling, and intercellular interactions. In this study, we investigated the arrangement of PS headgroups in mixed PS/phosphatidylcholine (PC) bilayers, serving as a simplified model of the outer leaflets of mammalian cell plasma membranes. Combining atomistic-scale molecular dynamics (MD) simulations with Langmuir monolayer experiments, we unraveled the mutual miscibility of POPC and POPS lipids and the intricate intermolecular interactions inherent to these membranes as well as the disparities in position and orientation of PC and PS headgroups. Our experiments revealed micrometer-scale miscibility at all mole fractions of POPC and POPS, marked by modest deviations from ideal mixing with no apparent microscale phase separation. The MD simulations, meanwhile, demonstrated that these deviations were due to strong electrostatic interactions between like-lipid pairs (POPC-POPC and POPS-POPS), culminating in lateral segregation and nanoscale clustering. Notably, PS headgroups profoundly affect the ordering of the lipid acyl chains, leading to lipid elongation and subtle PS protrusion above the zwitterionic membrane. In addition, PC headgroups are more tilted with respect to the membrane normal, while PS headgroups align at a smaller angle, making them more exposed to the surface of the mixed PC/PS membranes. These findings provide a detailed molecular-level account of the organization of mixed PC/PS membranes, corroborated by experimental data. The insights gained here extend our comprehension of the physiological role of PSs. |
38096497 | Polarization-Sensitive Asymmetric Scattering at the Single-Particle Scale via Surface Plasmon Resonance Microscopy. | Surface plasmon resonance microscopy (SPRM), based on the scattering of single molecules at the interface, is a highly efficient analytical platform widely used in the fields of biology and chemistry. Due to the interference scattering, the imaging pattern exhibits typical parabolic tail and phase transition features, providing a quantitative means of observing the changes in the physical and chemical properties of single molecules. In this work, we reported another unique asymmetric parabolic distribution pattern resulting from polarization conversion in the experiment based on SPRM. This microscopic-level feature is derived from the switching between SPR resonant and nonresonant states. Starting from energy flux theory, we constructed an analysis model and conducted full-wave numerical simulations to verify the experimental results. Furthermore, we demonstrate that the optical rotation induced by chiral thin films can be directly measured through imaging with asymmetric features, providing valuable insights into the field of chiral materials. The quantitative interpretation of asymmetric scattering not only advances the fundamental understanding of the imaging mechanism of SPRM, but also opens up possibilities for utilizing this polarization-sensitive characteristic for single-particle detection and sensing in the future. |
38096498 | Palladium-Catalyzed Synthesis of Indanone via C-H Annulation Reaction of Aldehydes with Norbornenes. | A novel methodology for the synthesis of indanone derivates has been developed. The palladium-catalyzed annulation reaction of <i>o</i>-bromobenzaldehydes with norbornene derivatives is achieved through extremely concise reaction processes. The indanone skeleton was established directly via C-H activation of the aldehyde group under a mild reaction condition. This method is simple and practical, which simplified the traditional synthesis method for the rapid construction of indanone. |
38096500 | Menin Inhibitors Trigger Leukemia Remissions. | Menin inhibitors have proven effective in patients with acute leukemias. A phase II study of revumenib yielded a response rate of 63% in patients with relapsed or refractory disease and KMT2A rearrangements; a phase I trial combining the drug with three chemotherapies also yielded complete remissions in patients with acute myeloid leukemia. A phase I study of a different menin inhibitor detected responses in 63% of patients with acute leukemia and certain gene alterations. |
38096499 | A Chemical Counterpart to the Resolution Step of Nature's Intein-Mediated Protein Splicing. | In the course of an attempted total chemical synthesis of the ant insulin-like peptide-2 (ILP2) protein molecule, specific cleavage of a backbone peptide bond in a branched ester-linked polypeptide chain with concomitant peptide splicing was observed. The side reaction was investigated in model compounds. Here, we postulate a chemical mechanism for this novel polypeptide backbone cleavage reaction as a chemical counterpart to the resolution step of biochemical intein-mediated protein splicing. |
38096501 | Alternatives for Epoxides in Graphene Oxide. | The structural mystery of the long-known graphene oxide (GO) unfolds as one of the most abstract conceptual problems among nanomaterials. Generally construed as the oxidized form of graphene, it is proposed to host a variety of functional groups with oxygen and hydrogen. Theoretical studies are abundant on the highly strained epoxides, while larger cyclic ethers having one or more oxygen atoms and vinylogous carbonyls are paid scant attention even though they are predicted by several structural models. The nature of the geometric and electronic structures of these alternative functional groups, the preferred distribution on the graphene lattice, comparative stability, etc., remain unexplored. Our systematic inquiry into the impact of hexagonal and periodic constraints on these mystic functional groups unveils several surprises. Among those that retain the hexagonal carbon backbone, epoxides are surprisingly more stable than larger ethers despite the excessive strain associated with their acute triangular geometry. Epoxidation conserves the planarity of the carbon backbone, which allows their optimal distribution on the lattice by reducing the repulsive interactions from oxygen lone pairs and π-electrons. These findings categorically rule out the possibility of 1,3-ethers in GO and settle the longstanding debate on its existence. They face severe steric repulsion even in low-dimensional systems that tear the σ-skeleton of graphene completely apart, reducing its dimensionality. We show that selective breaking of the σ-bonds is preferred over that of epoxides if backed by cyclic delocalization of electrons. Particularly, 1,6-diones in trans orientation are thermodynamically favored and justify the large holes experimentally observed through microscopic imaging. |
38096502 | The Stigma of Epilepsy among Patients Attending the Epilepsy Clinic at Connaught Hospital, Sierra Leone. | Epilepsy is one of the world's most common neurological disorders with about eighty percent of cases living in low and middle-income countries. Due to superstitious cultural and traditional beliefs in Sub-Saharan Africa, the stigma associated with epilepsy is particularly disabling. Stigma negatively affects the psychosocial wellbeing of people with epilepsy (PWE) and their acceptance of medical treatment. Very limited studies have been done on the types and extent of stigma in PWE in Sierra Leone. |
38096504 | Gene regulation supporting sociality shared across lineages and variation in complexity. | Across evolutionary lineages, insects vary in social complexity from those that exhibit extended parental care to those with elaborate divisions of labor. Here, we synthesize the sociogenomic resources from hundreds of species to describe common gene regulatory mechanisms in insects that regulate social organization across phylogeny and levels of social complexity. Different social phenotypes expressed by insects can be linked to the organization of co-expressing gene networks and features of the epigenetic landscape. Insect sociality also stems from processes like the emergence of parental care and decoupling of ancestral genetic programs. One underexplored avenue is how variation of a group's social environment affects the gene expression of individuals. Additionally, experimental reduction of gene expression would demonstrate how the activity of specific genes contributes to insect social phenotypes. While tissue specificity provides greater localization of the gene expression underlying social complexity, emerging transcriptomic analysis of insect brains at the cellular level provides even greater resolution to understand the molecular basis of social insect evolution. |
38096505 | Changes in the soil fungal communities of steppe grasslands at varying degradation levels in North China. | Studying the microbial community of grassland degradation is of great significance for grassland restoration. Thus, we used an Illumina HiSeq PE250 high-throughput sequencing platform to study the changing characteristics of soil fungal communities in degraded grasslands, which were categorized as non-degraded (ND), lightly degraded (LD), moderately degraded (MD), and severely degraded (SD). Moreover, a correlation analysis between soil physical and chemical properties and fungal communities was completed. The results showed that the number of plant species, vegetation coverage, aboveground biomass, and diversity index decreased significantly with increasing degradation, and there were significant differences in the physical and chemical properties of the soil among the different degraded grasslands. The dominant fungal phyla in the degraded grassland were as follows: Ascomycota, 44.88-65.03%; Basidiomycota, 12.68-29.91%; and unclassified, 5.51-16.91%. The dominant fungi were as follows: Mortierella,6.50-11.41%; Chaetomium,6.71-11.58%; and others, 25.95-36.14%; and unclassified, 25.56-53.0%. There were significant differences in the microbial Shannon-Wiener and Chao1 indices between the non-degraded and degraded meadows, and the composition and diversity of the soil fungal community differed significantly as the meadows continued to deteriorate. The results showed that pH was the most critical factor affecting soil microbial and fungal communities in SD grasslands, whereas soil microbial and fungal communities in ND grasslands were mainly affected by water content and other environmental factors. |
38096506 | Hydrogen sulfide regulates arsenic-induced cell death in yeast cells by modulating the antioxidative system. | Arsenic (As) is a metal with potentially toxic effects on different organisms. Hydrogen sulfide (H2S) plays a vital role in alleviating heavy metal toxicity through reducing oxidative stress in plants and animals. However, the function of H2S in alleviating arsenic toxicity in yeast cells remains unclear. In this study, we investigated the effects of NaHS (exogenous physiological H2S) on cell death and its possible mechanism in yeast cells induced by sodium arsenite. Our results showed that sodium arsenite could induce yeast cell death, and pretreatment with 0.05 mmol/L NaHS significantly alleviated sodium arsenite-induced cell death. Under sodium arsenite conditions, the content of malondialdehyde (MDA) increased together with inhibition of the catalase (CAT) activity, and the expression of CTT1 and CTA1 were down-regulated. However, the activity of the superoxide dismutase (SOD) increased, and SOD1 gene expression was markedly up-regulated in the group that treated by sodium arsenite. When the yeast cells pretreated with NaHS, the intracellular ROS and MDA content decreased significantly, and the activity of SOD and CAT increased significantly compared to the arsenic treatment alone. Our findings indicated that NaHS alleviated sodium arsenite-induced yeast cell death is mediated mainly by enhancing the antioxidant defense system. |
38096507 | ON THE RESULTS OF A SYSTEMIC MULTIFACTOR ANALYSIS WITH MATHEMATICAL MODELING OF THE INDICATORS OF MEDICAL EXPERTISE OF YOUNG MALES WITH SURGICAL DISEASES IN THE REPUBLIC OF ARMENIA. | Medical aspects of the organization of replenishment of the Armed Forces with healthy and physically strong personnel are of great importance, and the deficit in the number of conscripts and their low-quality condition have become one of the main and important problems for the Armed Forces. The aim of the study was to improve the medical care of male conscripts aged 18-27 years by revealing the regularities and peculiarities of the expert assessment of surgical diseases among this category of young men on the basis of mathematical modeling. The object of the research was the study of the names of surgical profile articles, according to which these people were recognized as unfit or restricted fit for service, and the results of military medical expertise. Descriptive, social, and statistical methods were applied in the course of the study. The final stage was to conduct a systemic multifactor analysis in order to obtain a mathematical model of the process under study. The values of the influence coefficients of the mentioned indicators for 2013-2019 on the obtained mathematical models from the point of view of military-medical expertise of young men with surgical diseases both in the Republic of Armenia as a whole and in its separate regions are presented. Summarizing, it can be stated that from the point of view of military-medical expertise of young men with surgical diseases it is impossible to consider Yerevan city and the regions of RA as separate parts of the Republic of Armenia. Yerevan and the regions of the Republic of Armenia as separate parts, as they appear as a single whole according to the results of systemic multifactor analysis with mathematical modeling. |
38096508 | EVALUATION OF VITAMIN K2 IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. | There is a rising interest in studying the possible therapeutic value of fat-soluble micronutrients like vitamin K2 for preventing or controlling type 2 diabetes mellitus. The present study was designed to evaluate levels of vitamin K2 in patients with type 2 diabetes mellitus. The study enrolled 60 patients with type 2 diabetes mellitus and 30 individuals as a control group. Blood samples were collected from each participant for estimation of vitamin K2 by (ELISA), HbA1c by (Cobas), lipid profile by (colourimetric methods) and calculated BMI. The mean±Standard Deviation (SD) of vitamin K2 levels for the type 2 diabetes group were (185.13±30.08) pg/ml, with a highly significant decrease (p<0.001) when compared with the control group (303.91±58.60) pg/ml. The HbA1c, cholesterol, TG, and LDL-C level for the type 2 diabetes group highly significant increase (p<0.001) when compared with the control while HDL-C decreased when compared with the control group. The current study concluded that: Vitamin K2 levels showed a highly significant decrease in patients with uncontrolled type 2 diabetes mellitus when compared with those in the control group. Vitamin K2 levels play an important role in improving glycated haemoglobin and lipid profiles in patients with type 2 diabetes mellitus. |
38096509 | PEDAGOGICAL ASPECTS OF THE IMPACT OF SMOKING ON THE HUMAN BODY BASED ON RADIOGRAPHIC DENSITY INDICATORS OF MAXILLARY SINUS BONE WALLS. | The most effective process of quitting smoking can be achieved through precise and complete identification of the adverse effects on the human body. The aim was to examine the influence of smoking on the density of the walls of the paranasal sinuses. 80 individuals of the young age and both genders were included into the research. Depending on the presence of pathological changes in the sinuses and smoking habits, all participants were divided into four groups. It was found that in the group of smokers without any paranasal sinus pathology, the density is 2.66% lower than the intact group. This figure is significantly higher in patients suffering from rhinosinusitis but not smoking, where it is 45.18%. The maximum difference from the control group is observed in individuals suffering from chronic rhinosinusitis and being smokers, with a difference of 81.03%. Pedagogical aspects of the impact of smoking on the human body based on radiographic density indicators of maxillary sinus bone walls were detected. It has been observed that smoking can exacerbate the negative impact of inflammatory processes in the paranasal sinuses. |
38096503 | Renoprotective effects of combination treatment with sodium-glucose cotransporter inhibitors and GLP-1 receptor agonists in patients with type 2 diabetes mellitus according to preceding medication. | Combination therapy with sodium-glucose cotransporter inhibitors (SGLT2is) and GLP-1 receptor agonists (GLP1Ras) is now of interest in clinical practice. The present study evaluated the effects of the preceding drug type on the renal outcome in clinical practice. |
38096510 | THE RHEOENCEPHALOGRAPHIC STUDY OF THE INTERHEMISPHERIC ASYMMETRY OF CEREBRAL BLOOD FLOW IN HEALTHY AND MENTALLY RETARDED CHILDREN. | Aim - to study functional organization of hemodynamic processes in brain basins of healthy children and children with mild mental retardation depending on the nature of asymmetry and gradient of cerebral blood filling are investigated. The research executed in the scientific laboratory of the special and inclusive education department of the Armenian State Pedagogical University after Kh. Abovyan and Armenian State Institute of Physical Culture and Sport. The study involved children aged 8 to 11 years, a total of 131. 73 of them are healthy schoolchildren and 58 children with a low degree of mental retardation. Each category of subjects was divided into 2 age groups: 8-9 years and 10-11 years. The results of the experimental study of task performance show that interesting data have been obtained which will serve as a basis for the development of necessary means, methods, and conditions for the development of elementary practical orientation in mentally retarded elementary school children. The analysis of the results of the study allows us to highlight the following important points: in the control group, 88% of the examined patients showed a hyperfrontal pattern in terms of RI (rheogramm amplitude). In seven children, the hypermastoidal pattern was observed, and in the two children of the control group, no significant differences between the RI values in the frontal and mastoidal basins were found. The study involved 131 children aged 8 to 11 years old. 73 of them were healthy with normal physical and mental development as well as 58 children with a weak degree of mental retardation. The study was undertaken to determine which sport and physical activity allowed children with mental retardation. Established that the parameter of TPWV in 8-9-year-old and 10-11-year-old schoolchildren of the control group was significantly higher than that of experimental children in the frontal, bimostoidal and hemispheric basins. |
38096511 | RELATIONSHIP BETWEEN VITAMIN D DEFICIENCY AND CHRONIC PERIODONTITIS. | Vitamin D deficiency may be associated with increased risk of chronic periodontitis. Aims - to clarify the relationship between vitamin D deficiency and Chronic periodontitis and to evaluate the effect of vitamin D on periodontal index. The investigation was carried out on 45 participants of ages within the range of (30-45 years) who were attending the private dental clinics. Diagnosis of chronic periodontitis was established depending on dental history, clinical examinations (periodontal indices). All participants were examined by the same dentist. They were classified into three groups: Group 1 (control negative): (15) participants with normal serum vitamin D3 level and with pocket depth ≤3 mm, good oral health and normal periodontal tissues and no previous history of periodontal diseases. Group 2 (control positive): (15) participants with normal serum vitamin D3 level and periodontitis with pocket depth ≥5 mm, they received placebo medication orally, Group3(treatment): (15) participants with vitamin D3 deficiency (below 30 IU), and periodontitis with pocket depth ≥5 mm, they received oral Vitamin D3 fast acting liquid soft gel capsule 2000 IU /day for 3 months. Serum Vitamin D level was measured before and after the study, 3 blood samples were taken from each participant at 0,45,90 days, for research examinations. The criteria of patients' selection include apparently looked healthy individuals, non-pregnant or lactating females. Vitamin D deficiency group (below 30 IU), there was no history of vitamin D allergy and did not take any medication or supplements or herbals for the last 1month, non-smoking, and non-alcoholic. Deep scaling and root planning were done for every participant in all groups (except control negative) to reach the base line for periodontal index. A written instruction was supplied to each patient about standard oral hygiene home care. After one week, the periodontal indices and radiographical examination was measured for all participants with blood collection and after 45,90 days. Vitamin D level measured before and after research steps. There was significant reduction in periodontal indices in 45, 90 days of the study which mean good response to the treatment and improvement in pocket depth. Conclusion: Vitamin D3 supplement can be a good adjuvant in chronic periodontitis. |
38096512 | CORRELATES OF ATOPIC DERMATITIS CHARACTERISTICS IN MILITARY PERSONNEL. | Atopic dermatitis, despite its relatively wide distribution and low severity, was statistically often a disqualification condition for military service. The aim of our study is to determine correlations between characteristics of atopic dermatitis in military personnel. 144 people with atopic dermatitis were under our observation, 78 of them military personnel, 26 military family members and 40 civilians, 62 men and 82 women. We studied the following characteristics: gender, age, marital status, education, social status, place of service location, genetic anamnesis, recurrence during the year, laboratory indicators of attached infections, focus of localization, other skin diseases, comorbidities, compliance with hygienic conditions, wearing a military uniform, the frequency of changing bed linen. 3-5 times recurrence a year shows a reliable positive correlation with: wearing a uniform for 12-24 hours, SSA/eosinophilia, mycosis, pathology of the respiratory system, military personnel. Staphylococcus aureus is associated with other infections - St. hominis, fungus, also shows a reliable positive correlation: localization on the face and torso, wearing the uniform for 1 week and more. Staphylococcus hominis shows a reliable positive correlation: localization - torso, wearing uniform for 1 week or more,y. Shows a reliable positive correlation with fungus: localization scalp, neck, lower limb, military serviceman; reliable positive correlation with SSA/eosinophilia: increased IgE, localization on the upper limbs, mycosis, change of bed linen - once every 2 weeks; IgE - localization of dermatosis on the upper limbs and torso area, pathology of the digestive system, changing bed linen once every 2 weeks, military serviceman. It shows a reliable positive correlation with helminthiasis: Localization on the genitals, mycosis, pathology of the digestive system, change of bed linen once a month. Development and recurrence of atopic dermatitis in military personnel correlates with living conditions and infections. Determining the differences between civilian and military patient populations will allow clinicians to better investigate the risk factors that predispose to the manifestation of dermatitis in the military. |
38096513 | AN IN-DEPTH ASSESSMENT OF THE TUMOR'S IMPACT ON SARCOPENIA. | Loss of muscle mass is a typical symptom of cancer and it is strongly correlated with poor prognosis. Cancer-related Sarcopenia is unresponsive to conventional dietary changes and exercise, in contrast to age-associated muscle atrophy. This particular type of weakness differs from different kinds of muscle loss in that it is triggered by a number of interrelated mechanisms, notably inflammatory processes, abnormal metabolic processes, proteolysis, and autophagy. This research is to examine evidence supporting the theory that tumors have a causal role in causing muscular atrophy. It seeks to investigate the precise regulators that the tumour generates and how they affect the processes that result in muscle waste. The evaluation looks for new directions for further studies and medical treatments. The analysis is based on a thorough examination of the scientific literature and research that shows how tumor and muscle atrophy are related. It concentrates on studies that clarify the numerous strategies by which malignancies cause the loss of muscle. This article highlights particular mechanisms by which these tumor-derived substances affect the development of muscle loss, including inflammatory processes, metabolic disturbance, proteolysis, and autophagy. The discovery of such targets offers hope for the creation of efficient treatment strategies that can enhance the long-term outlook and quality of life of cancer sufferers who are experiencing muscle loss. |
38096514 | ASSESSMENT OF THE QUALITY OF LIFE AND PREVALENCE OF POSSIBLE OSTEOPOROTIC CHANGES IN POSTMENOPAUSAL WOMEN IN YEREVAN BASED ON DATA OF THE ECOS-16 QUESTIONNAIRE. | The aim of the study was to conduct approximate assessment of the prevalence of osteoporotic changes and evaluate quality of life (QoL) in postmenopausal women using ECOS-16 questionnaire in Yerevan city. The cross-sectional survey was conducted for data collection among 196 postmenopausal women. The research material about QoL was collected using ECOS-16 questionnaire. The sample was randomly selected through a two-stage cluster sampling from the population of women served by five policlinics of Yerevan. The majority of surveyed women (70.3%) were in age group under 60. Slightly more than half of the study participants (57.7%) had higher education and worked (59.2%). Almost two thirds of respondents were married (65.3%). Half of the respondents (51.0%) noted their income at the subsistence level. 71.9%±3.21 of women reported back pain for a long time. The scores of all the scales of ECOS-16, as well the total score were significantly higher in women who reported chronic back pain, indicating a lower quality of life for them. Women in age group under 60 years old, as well as women indicating absence of risk factors at workplaces, had significantly higher quality of life. A statistically significant difference was also observed between groups of women based on such social and demographic characteristics, as marital status, and average monthly income level. Pairwise comparison of groups based on these characteristics revealed a higher quality of life among married women compared to widows (p=0.043) and among women with income higher and at the subsistence level compared to the group of women with income below the subsistence level (p= 0.010). Poor QoL was associated with low self-reported health status and presence of chronic diseases in women. Pairwise post-hoc analysis showed lower level of QoL in the study participants with a below average/low level of health compared to both, those with above average (p<0.001) and average (p<0.001) level of health. QoL was also lower in women with four or more chronic diseases compared to both, women without chronic diseases (p=0.001) and the group of women with 1-3 diseases (p=0.001). The prevalence of chronic back pain, which was considered as one of the manifestations of undiagnosed osteoporosis in postmenopausal women, was quite high. The scores calculated for all dimensions of ECOS-16 questionnaire, as well the total score indicated lower quality of life among women reported chronic back pain compared to those who did not have such a health problem. Age older 60, spouse's demise, income below the subsistence level, smoking, presence of risk factors at workplace, as well as poor self-reported health status, and presence of chronic diseases were the factors negatively affected the QoL of surveyed women. |
38096515 | CUBITAL TUNNEL SYNDROME DUE TO AN INTRANEURAL GANGLION CYST OF THE ULNAR NERVE. | Cubital tunnel syndrome is the second most common neuropathy of the upper extremity. Cubital tunnel syndrome caused by intraneural ganglion cysts is rare in clinical practice. We present the case of a 71-year-old male patient with a 4-month history of cubital tunnel syndrome of the left elbow due to an intraneural ganglion cyst. After revision of the ulnar nerve and resection of the intraneural cyst nearly complete recovery was achieved within a 5 month follow-up but some sensory deficits of the fifth fingertip. We recommend preoperative ultrasound examination of the cubital tunnel even in cases with clear diagnosis. Ganglion cyst as a cause of cubital tunnel is rare but needs to be diagnosed and treated as soon as possible to prevent irreversible complications. |
38096516 | PREDICTION OF IRON DEFICIENCY IN CHILDREN USING EASY LABORATORY TOOLS. | Iron deficiency anemia is a common condition in children that can impair growth and development. This study aimed to evaluate the utility of easy, routinely available laboratory tests in predicting iron deficiency anemia. Medical records of 55 children (mean age 4.9±3.2 years) with laboratory evaluation of anemia were analyzed retrospectively. Parameters included complete blood count, serum iron, total iron binding capacity (TIBC), serum ferritin and transferrin saturation. Based on reference ranges, hemoglobin, hematocrit, serum ferritin and transferrin saturation were reduced below normal, indicating clear iron deficiency. Although within normal limits, red blood cell count, mean corpuscular volume, mean corpuscular hemoglobin and serum iron were close to lower limits, suggesting subtle deficiency. In contrast, red cell distribution width, platelet count, white blood cell count, TIBC and unsaturated iron binding capacity were unaffected. In conclusion, hemoglobin, and hematocrit from complete blood count, along with subtle changes in some of the red cell indices, can strongly suggest, iron deficiency anemia in children, Taking into consideration the increased body demand of iron in this age group with follow-up to ensure a desirable response, with less need for more advanced iron studies. These widely available, inexpensive tests may facilitate early detection and treatment of this common pediatric condition. |
38096517 | THE OCCURRENCE OF SPORTS INJURIES AMONG PRE-ADOLESCENTS. | Preschool children's harmonious development, cognitive and communicative abilities are enhanced through physical activities in sports, yet sports training and competition pose a risk of injury to children aged three to seven years due to their physiological and psychological features. Although sports injuries in preschool children are not common, they can be undesirable and unavoidable, and fortunately, these injuries are usually reversible. This review article presents data on the physiological features of the developing musculoskeletal system and its relationship to sports injuries in children, which together determine the nature of children's sports injuries. We also present a classification of sports injuries among preschool children, based on the literature, which considers the type, location, and severity of the trauma as estimated by the duration of mandatory missed practice. |
38096518 | EVALUATION OF FETUIN-A LEVEL IN POLYCYSTIC OVARY SYNDROME AND ITS ASSOCIATION WITH ASPROSIN AND SOME BIOCHEMICAL PARAMETERS. | An ovarian cyst is a common hormonal disorder that affects the ovaries in females of reproductive age. Environmental and genetic factors may contribute to the beginning of the disease, although the lack of a clear aetiology. Menstrual irregularities, increased hair growth, and acne are some of the most important signs. In order to control symptoms and prevent the development of chronic medical disorders, early identification is essential. The goal of this study was to assess fetuin-A levels and relationships in polycystic ovary syndrome (PCOS) patients. The connection between fetuin-A and asprosin and several biochemical parameters, including fasting blood sugar, insulin, cholesterol, and triglycerides in women patients with polycystic ovarian syndrome. Ninety females were included in the trial; 60 individuals (females) were selected who were diagnosed with PCOS by a gynaecological specialist and ranged in age from 15 to 45. The result was a change in the ovulation-inducing hormones LH and FSH as well as an increase in the proteins fetuin-A and Asprosin. On the other hand, 30 individuals (all female) were used as a control group. Their ages were recorded as well as the fact that they did not have PCOS. For all groups, laboratory tests were done to determine the levels of fetuin-A, Asprosin, fasting blood sugar, Insulin, total cholesterol, and triglyceride. For parents and a control group, investigators performed an asprosin analysis, The findings of the comparison were statistically not significant (P value=0.115). performed a Fetuin-A analysis as well, the results were statistically highly significant with a P value of 0.0002 when compared to the outcomes of the two sick groups and the healthy controls. |
38096519 | THERAPEUTIC USE OF RESVERATROL IN THE TREATMENT OF NEUROLOGICAL AND ENDOCRINOLOGICAL PATIENTS. | The article represents the data characterizing the use of resveratrol in the treatment of various diseases, including endocrinological and neurological. It was shown that resveratrol is widely used in the treatment of various diseases due to its ability to actively suppress the inflammatory process. At the same time, in autoimmune diseases resveratrol inhibits the function of the entire population of T-cells, but when it comes to the neoplastic process, it only inhibits the activity of a subpopulation of T-cells (Treg). Thus, resveratrol can be recommended in the treatment of any diseases associated with the activation of the T-cell immunity. |
38096520 | AN EVALUATION OF ANTIBIOTIC PRESCRIPTION PRACTICES: PERSPECTIVES OF VETERINARY TRAINEES AND PRACTICING VETERINARIANS. | Antibiotic resistance is a major worldwide problem that has an impact on the well-being of humans as well as animals. Antibiotic resistance is caused by the misuse and excessive use of antibiotics. The key to reducing this issue lies in educating veterinary medical learners on the proper and accountable utilization of antibiotics for the care of animals. Objective - using awareness-raising and instruction as the foundation, this research of Indian veterinary learners can help resolve the issue of antibiotic resistance throughout the care of animals. The questionnaire survey was taken between June and July 2022 and it was aimed at learners registered in veterinary medical studies at academic and research institutions in India. The study included 500 pupils overall. The purpose of the survey was to gather information about students' knowledge of antibiotics, including antibiotic resistance, as well as their feelings on the consequences of antibiotic resistance on the globe at large and their acquaintance with the one health ideology. According to this study's findings, 83.3 percent of respondents thought antibiotic resistance was a serious problem. 57.92 percent of respondents understood the issue's worldwide consequences and its one health ideology. The study emphasizes the significance of expanding the veterinary educational program to include thorough instruction on prudent antibiotic usage and the concepts of one health. |
38096521 | CHANGES IN SPERMATOGENESIS AFTER SIMULATED INGUINAL HERNIA REPAIR IN EXPERIMENT. | The Lichtenstein method revolutionized the treatment of inguinal hernias. But this method is accompanied by serious complications, as evidenced by the publications of recent years. Such complications include the development of fibrous changes in the scrotum, deejaculation, obstructive azoospermia, oligospermia. Therefore, in the treatment of inguinal hernia, the so-called isolation methods are becoming more and more relevant, which implies complete isolation from the rope mesh and does not affect spermatogenesis. Aim of the study - to compare the morphological parameters of sperm before and after hernia surgery in the groups that underwent modeled herniaplasty by Lichtenstein's method and with spermatic cord isolation from a mesh by Gvenetadze. 16 male rabbits aged 12 months ± 3 months, weighing 3.5 ± 0.5 kg were included in the study. Of these, 8 (50%) underwent hernioplasty by Lichtenstein's method, and 8 (50%) - with complete isolation of Bagirak. Gvenetadze's method. Rabbits were divided into two groups. The first group: 8 rabbits, which underwent Lichtenstein's hernia surgery. The second group: 8 rabbits, which underwent hernioplasty with complete isolation of the sacrum using the Gvenetadze method. In both groups, a spermomorphocytological study was performed 2 days before the operation and 3 months and 6 months after the operation. The study included a complete spermomorphocytological examination by studying the following sperm parameters: sperm volume, color, turbidity, ejaculatory time, stickiness, odor, PH, number of spermatozoa in 1 ml, number of spermatozoa in the whole ejaculate, live spermatozoa, motile spermatozoa, progressive motile spermatozoa, Normal morphological of permatozoites Molds, leukocytes, erythrocytes, lipoid bodies, spermagglutination, fungi, bacteria, mucus. Semen were collected 2 days before surgery, 3 months after surgery, and 6 months after surgery. The sperm was obtained using the so-called "artificial vagina". Our study showed that inguinal hernia repair with spermatic cord isolation does not affect spermatogenesis. |
38096522 | EFFECT OF INHALED OXYGEN CONCENTRATION ON PULMONARY GAS EXCHANGE DURING OFF-PUMP CORONARY BYPASS GRAFTING. | Aim of study - supra-physiologic level of PaO2, securing oxygen reserves and preventing perioperative hypoxia, may offset the reduced oxygen delivery during cardiac surgery. However, high FiO2 will speed up gas absorption in low V/Q regions, promote atelectasis formation and increase pulmonary shunt fraction. PaO2/FiO2, P(a-Et)CO2 and PEtCO2/PaCO2 are the variables linked to CO2 and O2 exchange impairment. The aim of our study was to assess pulmonary gas exchange performance while ventilating patients with different FiO2 during OPCABG. The seventy patients were randomly equally distributed in two groups: H (High) and L (Low). The patients in the group H were ventilated with FiO2 0.8 and the patients in the group L _ with FiO2 0.5. PaO2/FiO2 ratio, P(a-Et)CO2 gradient and PEtCO2/PaCO2 ratio were checked at the start and the end points of operations. PaO2/FiO2 decreased, P(a-Et)CO2 increased and PaCO2/PEtCO2 decreased at the end of operations compared with the start values in both groups. PaO2/FiO2, P(a-Et)CO2 and PaCO2/PEtCO2 ware different between H and L groups. The difference became statistically significant at the end of operations. (PaO2/FiO2 326±65 vs 290±63 p=0.020; P(a-Et)CO2 5.7±2.3 mmHg vs 7.5±2.4 mmHg p=0.003; PaCO2/PEtCO2 0.84±0.05 vs 0.80±0.06 p=0.001). The groups were comparable according to the outcomes such as hemodynamic and laboratory data, duration of postoperative mechanical ventilation and ICU length of stay. FiO2 0.8 was associated with more derangements of pulmonary gas exchange compared with FiO2 0.5. Although FiO2 did not have an impact on the outcomes we studied, using FiO2 0.5 seems to be safer in patients undergoing OPCABG. |
38096523 | COQ10 PROVIDES CARDIOPROTECTION AGAINST THE TOXIC EFFECTS OF TRASTUZUMAB AND DOXORUBICIN IN RAT MODEL. | The study was aimed at investigating the effect of coenzyme Q10 (CoQ10) on reducing the cardiotoxic effects of trastuzumab (TRZ) and doxorubicin (DOX) in a rat model. The experiment duration was 20 days and involved sixteen healthy albino rats, subdivided into four groups: the negative control group, in which rats received a daily dose of a placebo vehicle; the positive control group, receiving a daily placebo vehicle and a single dose of a combination of TRZ+DOX; the third group, pretreated with CoQ10 (10 mg/kg orally daily for 10 days), followed by 10 days of placebo vehicle and a single dose of a combination of TRZ+DOX at day 10; and finally, the fourth group pretreated with 10 days of placebo vehicle then followed by CoQ10 (10 mg/kg orally daily for 10 days) and a single dose of a combination of TRZ+DOX at day 10. Histological analysis of cardiac tissues was conducted, and the serum levels of cardiac troponin and redox markers were evaluated. The results showed that there were several histopathological changes like necrosis, edema, inflammation, and others in Group 2, which did not receive CoQ10, with high serum levels of cTnI. However, a high degree of improvement was achieved in Groups 3 and 4 in which rats were administered CoQ10 either before or after TRZ and DOX administration. The improvement was expressed by the disappearance of histopathological changes and a significant decrease in the serum level of cardiac troponin compared with Group 2. The findings of the study suggest that the administration of CoQ10 could be beneficial in minimizing the cardiac side effects caused by TRZ and DOX. This study provides a basis for further research and development of CoQ10 as a potential cardioprotective agent against the cardiac side effects of chemotherapy. |
38096524 | UNDERSTANDING THE VITAL DETERMINANTS SHAPING LEARNERS' PHYSICAL ACTIVITYAND PSYCHOEMOTIONAL WELLBEING IN THE COVID-19 PERIOD. | The Corona Virus (COV-19) epidemic significantly affected the educational environment, requiring a quick transition to distance and blended learning methods. This extraordinary disruption had an incredible impact on pupil's levels of physical activity (PA), psycho-emotional health (PEH) and engagement with academic material. The research aims to examine the vital determinants that influenced various areas of learners' lives during CoV-19. The purpose of this 600-person study was to collect data on the subjects' overall health and PA levels for the CoV-19 pandemic. The SPSS application was used to process the questionnaire's collected data. The information given reveals the respondents' degree of PA throughout the quarantine. According to the breakdown, 15% indicated low levels of PA, 39% reported medium levels and 46% reported high levels. The data show that, despite the respondents' different levels of PA, little PA predominated for most of them. The limitations of distance learning throughout quarantine and the prevalent recommendation of leaving residence for necessary reasons were blamed for this tendency. There were fewer prospects for higher-intensity PA due to these circumstances. |
38096525 | TRAUMATIC PULMONARY HERNIATION: A RARE CHEST TRAUMA MANIFESTATION. | Traumatic pulmonary hernia is an uncommon occurrence resulting from chest trauma, typically covered by the skin. Chest trauma may arise from penetrating or blunt mechanisms, with blunt trauma being more frequently observed. When lung herniation transpires, various symptoms such as chest pain, dyspnea, subcutaneous emphysema, bone crepitation, and hemoptysis (in cases of lung parenchymal damage) may manifest. We present the case of a 66-year-old woman suffering from chest pain and dyspnea after blunt chest trauma due to a fall induced by delirium following alcohol abuse. |
38096526 | ASSOCIATION OF NESFATIN-1 AND INSULIN RESISTANCE IN OBESE ADOLESCENTS OF IRAQ POPULATION. | Nesfatin-1 reduces body weight and the intake of food, it is also tangled in setting insulin release. This study aims at comparing the levels of serum of Nesfatin-1 with the insulin resistance in obese adolescent of iraqi population with other nations around the world predicating development of diabetes mellitus later. 90 participants were needed for this cross-sectional study, including 30 control participants (17 men and 13 women) and 60 obese adolescents (36 men and 24 women). Serum glucose, insulin, and glycated hemoglobin in starved participants were estimated, using an ELISA kit, the serum level of Nesfatin-1 was measured, and insulin resistance was calculated. Obese adolescents aged 12 to 18 and the control group, who were between 13 and 18 years old. The level of nesfatin-1 was significantly lower in the group of obese adolescents than in the controls. The ranges of Nesfatin-1 were (1.22±0.39 n/ml vs 2.54±0.64 n/m P = 0.001). In the control and obese groups respectively. In comparison to the results of the non-obese adolescent group, the obese group has significantly lower insulin sensitivity. Serum Nesfatin-1 is negatively associated with insulin sensitivity, lipid profile, and body mass index. In general, our study revealed that there is no effect of food culture and eating intake on the role of Nesfatin -1 inducing obesity. |
38096527 | A THOROUGH STUDY AND META-ANALYSIS OF THE PROGNOSTIC RELEVANCE OF THE C-REACTIVE-ALBUMIN RATIO IN ACUTE PANCREATITIS. | Although most cases of acute pancreatitis (AP) are minor, severe cases are associated with a substantial risk of death. Acute pancreatitis (AP) is a common illness. Therefore, it is critical to assess AP severity as soon as possible. This review aimed to ascertain the predictive significance of the CRP to albumin ratio in individuals with AP. We searched PubMed, Science Direct, and Cochrane Library electronic databases Until January 2023. Studies that reported the CRP/alb ratio at admission and its relationship to the severity or death of patients with AP were included. Using a random-effects model, we computed the pooled mean difference (MD) and 95% confidence interval (CI). The quality of the included studies was evaluated using the Newcastle-Ottawa scale. This meta-analysis combined data from six trials with a total of 2244 patients. Upon admission, the CRP/alb ratio was higher in patients with severe AP than in those with mild to moderate AP (pooled MD:3.59; 95% CI:2.51-4.68; p<0.00001). Additionally, non-survivor AP patients had a substantially higher CRP/alb ratio than survivor AP patients (pooled MD:2.12; 95% CI:0.43-3.8; p<0.01). Individuals with AP may benefit from a high CRP/ALB ratio as a preliminary indicator of poor prognosis. |
38096528 | POTENTIAL LIFE PROGNOSTIC MARKER FOR MESENCHYMAL TUMOR RESEMBLING UTERINE LEIOMYOSARCOMA. | Benign uterine leiomyoma (U.LMA) and malignant uterine leiomyosarcoma (U.LMS), both uterine mesenchymal tumors, are distinguished by the number of cells exhibiting mitotic activity. However, uterine mesenchymal tumors contain tumor cells with various cell morphologies; therefore, making a diagnosis, including differentiating between benign and malignant tumors, is difficult. For example, cotyledonoid dissecting leiomyoma (CDL) or uterine smooth muscle tumors of uncertain malignant potential (STUMPs) are a group of uterine mesenchymal tumors for which a differential diagnosis is challenging. To date, a standardized classification system for uterine mesenchymal tumors has not yet been established. Furthermore, definitive preoperative imaging techniques or hematological examinations for the potential inclusion of CDL or STUMP in the differential diagnosis have not been defined. Several clinical studies have reported that there is no correlation between biomarker expression and mitotic rate or tumor recurrence. The immunohistochemical biomarkers reported so far cannot effectively help determine the malignant potential of CDL or STUMPs in patients who wish to become pregnant in the future. The establishment of gene expression profiles or detection of pathogenic variants by using next-generation molecular techniques can facilitate disease prediction, diagnosis, treatment, and prognosis. We examined the oncological properties of STUMP in adults using molecular pathological techniques on tissue excised from patients with uterine mesenchymal tumor. In a clinical study conducted by our medical team, the results of gene expression profiling indicated factors that may be associated with malignancy of uterine mesenchymal tumors. We herein describe the problems in diagnosing uterine mesenchymal tumors along with the results of the latest clinical studies. It is expected that the establishment of a diagnostic method targeting the characteristics of mesenchymal tumor cells will lead to the treatment of malignant tumors with a low risk of recurrence and metastasis. |
38096529 | PECULIARITIES OF IMMUNE STATUS IN THE PRESENCE OF SECONDARY IMMUNODEFICIENCY OF INFECTIOUS AND NON-INFECTIOUS ORIGIN IN WOMEN OF REPRODUCTIVE AGE. | The design of studies on the immune system does not have gender peculiarities, but the information about the higher frequency of pathology of the female reproductive system in the presence of immunodeficiency condition determines the purpose of this study, namely, to identify the features of immune status in the presence of secondary immunodeficiency of infectious (i.e., HIV infection, AIDS stage) and non-infectious origin (alcohol dependence syndrome) and their combination in women of reproductive age. The material for the study of cellular and humoral immunity was a lymphocyte suspension obtained by centrifugation of peripheral blood (taken within 12 hours after death) in women of reproductive age with HIV infection (AIDS stage), alcohol dependence syndrome and their combination. Immunological examination included the determination of quantitative indicators of cellular immunity using monoclonal antibodies: T-lymphocytes (CD3) and their main subpopulations of T-helper cells (CD4), cytotoxic lymphocytes (CD8), CD4/CD8 immunoregulatory index; as well as indicators of humoral immunity: B-lymphocytes (CD19) and immunoglobulins of the main classes (IgA, IgG, IgM). Additionally, interleukins IL-6 and IL-10 were studied to determine the parameters of the cytokine profile. The study indicates that the number of leukocytes and lymphocytes in the group of deceased women with alcohol dependence syndrome was 3.6±0.38x109/l and 0.82±0.35x109/l; in deceased women with HIV/AIDS, these indicators were reduced - 2.9±0.03x109/l and 0.39±0.04x109/l, respectively; and in deceased women with combined pathology (AIDS and alcohol dependence syndrome), they were reduced even more intensively - 2.7±0.04x109/l and 0.35±0.06x109/l (p<0.01). Compared to the control group - 5.22±0.4x109/l and 1.73±0.21x109/l - the number of leukocytes and lymphocytes was reduced in all study groups. In the group of deceased women with alcohol dependence syndrome, significant impairments in the proliferative activity of T-lymphocytes (CD3) and their subpopulation (CD4), as well as B lymphocytes (CD19) and natural killer cells (CD16) were found compared to the group of healthy individuals. Thus, in the control group, the percentage, and absolute values of CD3 were 60.37±4.2% and 1.04±0.05×106/l, and in women suffering from chronic alcoholism, they were statistically significantly lower - 49.1±3.1% and 0.42±0.08×106/l, respectively, p<0.01. The same tendency was found when comparing the values of T-helper cells (CD4) in the control group (44.2±2.9% and 0.76±0.13×106/l) and in deceased patients suffering from chronic alcoholism (33.7±4.6% and 0.28±0.23×106/l), p<0.01. Secondary immunodeficiencies of infectious and non-infectious origin in women (in particular, those formed in HIV/AIDS, alcohol dependence syndrome and their combination) are characterized by negative changes in the cellular and humoral components of the immune system, as evidenced by the presence of transient immunodeficiency, activation of cytolytic and auto aggressive reactions. As a result of these processes, systemic and organ pathology develops, in particular, weakening of the body's resistance to various infections and pathological changes in organs and tissues, which may be one of the links in the development of pathological processes in internal organs and tissues. |
38096530 | UNDERSTANDING THE ADAPTATION AND SENSITIVITY OF THE MICROBIOME: MICROBIAL RESILIENT AND HUMAN WELL-BEING. | The term microbiome describes the assortment of microbes that dwell in and on a person's body, particularly in the gut, comprising fungi, bacteria, infectious agents and additional microbes. According to research, numerous elements of human well-being, such as digestion, immunological response and psychological well-being, have been linked to the microbiome. Preserving human wellness requires knowledge of the microbiome's stability and how it reacts to perturbations. According to preliminary research, adults' microbial ecosystems are considered stable with no signs of significant disturbances. This stability is not preserved by inertia and the system's interaction with restorative forces keeps the processes stable. Short antibiotic doses can result in quick and substantial microbiome alterations. However, there is confirmation that the taxonomic structure of the microbiome has at least recovered after such disruptions. The effect of antibiotics is individualized and can be altered by earlier exposure to a similar drug, which is a crucial aspect to remember. These results suggest that the individual's microbiome has adaptable qualities. Examining the microbiome's reactions to perturbations might be helpful in the prediction of potential instabilities and illness by revealing important features of function, microbial connections, and important species in the native microbiota. This information can benefit the management of the individual microbial community and the promotion of better health conditions. |
38096531 | FACTORS OF AGGRESSION AT THE STAGES OF OPEN SURGICAL TREATMENT OF SEVERE FORMS OF PERITONITIS. | There are many unresolved questions regarding the features of surgical aggression in the open method of treatment of severe forms of peritonitis. There are isolated publications in the literature on the risk features of these interventions, despite the high prevalence of the problem. The purpose of this study was to study the features of surgical aggression in the open method of treatment of severe forms of peritonitis. The study included 205 patients with severe forms of purulent peritonitis treated at the Emergency Hospital in Aktobe (n=205). To assess the factors of surgical aggression, the reliability of the results was evaluated by variational statistics according to the Student's t-criterion, taking into account the degree of freedom, at p<0.05 and p<0.01, with the calculation of arithmetic averages and their average errors (M+m). The data are presented as an average value±standard deviation or median and percentiles, p-values less than 0.05 were considered significant. Based on the results obtained, it was found that the frequency of repeated laparosanation surgical interventions in one patient was 2.8±0.3 times against the background of purulent-inflammatory process in the abdominal cavity, a high degree of stress index of the regulatory systems of the body during sanitation was revealed - up to 1460.9±101.5 units, postural reactions of blood circulation and respiration in 7.55% and metabolic disorders homeostasis. Aggressive factors affecting patients and causing the risk of multiple laparosanation interventions at the stages of open surgical treatment of severe forms of peritonitis have been identified. The data obtained can be used to develop therapeutic and preventive measures to improve the results of treatment of severe peritonitis. |
38096532 | COVID-19 SAFETY MEASURES AND THEIR EFFECTS ON GAMBLING HABITS: AN INVESTIGATIVE STUDY. | This study looked at the way COVID-19 was starting to affect gambling during first six weeks of emergency actions. The following factors were evaluated: the economic effect of COVID-19 on internet gambling, according to COVID-19, psychological issues, addiction to drugs, and risky gambling habits and intentions. Online survey with cross-sectional data of 2015 gamblers was conducted, with a subsample of 1048 people who gambled online (age 18 and older). Numerous metrics of correlation and probability ratio analyses were performed. The Issue of Gambling Intensity Index's extremely dangerous gamblers and those who have gambled online are more likely to engage in gambling online, according to the outcomes, even though there was an obvious transition toward physical gaming. The most predicted indicators for high-risk gamblers on the internet were moderate to severe depression and anxiety, reduced work weeks, convincing themselves to gamble by COVID-19, gambling under the effects of alcohol or cannabis, and dangerous gambling motivations related to psychological disorders, such as gambling to relieve anxiety and depressive disorders, chasing gambling damages, and trying to make money from gambling. This research has validated numerous risk connections associated with gambling risk, psychological issues, and substance use reported in previous studies on the worldwide recession and upcoming COVID-19-related investigations. In contrast to many other inquiries, the current research considers each component comprehensively. It offers more information on the risk factors associated with online gambling throughout the epidemic. |
38096533 | AWARENESS AND KNOWLEDGE OF OBSTRUCTIVE SLEEP APNEA AMONG THE POPULATION OF THE AL-BAHA REGION OF SAUDI ARABIA: A CROSS-SECTIONAL STUDY. | Obstructive sleep apnea (OSA) is a known sleep-disordered breathing, with known morbidity and mortality, that affects a lot of people worldwide. In Saudi Arabia, the prevalence of OSA is estimated to be around 8.8% among adult males and 5.1% among adult females. The research is a cross-sectional study design conducted in the Al-Baha region; Saudi Arabia in 385 participants. To evaluate the knowledge and awareness of OSA, the study utilized a validated and reliable adapted Arabic version of the OSA questionnaire. The degree of consciousness and understanding regarding OSA demonstrated a noteworthy connection with varying levels of education and a favorable family history of OSAS (p<0.05). The regression analyses unveiled that people with a familial OSA background had a 2.565-fold increased likelihood of identifying daytime fatigue as a symptom of OSA (p<0.05). The study reported an insufficient level of awareness and knowledge of OSA among the Saudi Arabian population. Various factors, including gender, education, and family history of OSA, may affect the awareness and knowledge of this condition. |
38096534 | INFLUENCE OF SEROLOGICAL MARKERS OF BLOOD GROUPS ON THE DEVELOPMENT OF VISUAL MEMORY FUNCTION IN YOUNG FEMALE ATHLETES AGED 13-15 YEARS. | The article investigates the influence of serological markers of blood groups on the development of the mental function of visual memory of young female athletes aged 13-15 years. The study involved girls of a specialised sports institution (n=168), who were divided into two groups: group A - speed and power sports (n=83); group B - endurance sports (n=85). The control group consisted of female students of secondary schools aged 13-15 years (n=113) and female students of higher education institutions aged 17-20 years (n=213) who do not engage in sports. The study of short-term visual memory function was conducted using the method of "memory for geometric shapes", which was proposed by Makarenko M.V. in co-authorship. The person had to memorise the location of 7 figures within 30 s and then reproduce them on a blank registration form within 45 s. The number of figures correctly drawn and placed in the form (correct answers) and the number of errors made by the person during the entire period of work were counted. The fact of possible use of blood groups in genetic prediction of the development of visual memory of the subjects was established. It was found that female students with blood group 0(I) who do not engage in sports have the best associative relationships with the properties of the mentioned function, while the worst relationship remains unclear. In female athletes with blood group 0(I), there is only a tendency towards improved development of the above function. The factor of sexual dimorphism does not make significant adjustments to the specifics of changes in visual memory function. |
38096535 | EXPLORING CLINICAL VARIATIONS AND CO-MORBID TRENDS IN PD-MCI GROUPS. | Parkinson's Disease in Mild Cognitive Impairment (PD-MCI) is a complex condition characterized by a variety of cognitive problems that coexist with the physical symptoms of Parkinson's disease (PD). This study aims to examine the different medical indicators and associated tendencies among different PD-MCI groups. We investigated 132 people who had been given PD-MCI diagnoses. Utilizing SPSS, statistical evaluations are carried out. In overall PD-MCI variants, this investigation found that visuospatial ability and attentional/executive performance are the most impaired cognitive areas. It was also noticed that distinct PD-MCI groups had variances in their neurological characteristics, in multi domain amnesia (Non-Memory) PD-MCI patients exhibiting especially severe issues with unstable posture and walking. The intricacy of PD- Mild Cognitive Impairment (MCI) is highlighted by those results, which also imply that the interplay between mental and physical signs may be controlled by a number of interrelated factors, such as particular cognitive areas, brain surfaces, and the general level of cognitive impairment. |
38096536 | METASTATIC NODULAR MELANOMA DEVELOPING ON NEVUS SPILUS DURING INTAKE OF BETA BLOCKERS (BISOPROLOL/NEBIVOLOL) AND ACE INHIBITORS (PERINDOPRIL). POTENTIAL LINKS TО THE DRUG RELATED NITROSOGENESIS/CARCINOGENESIS, DUNNING-KRUGER EFFECT AND GENETIC WEAPONS OF THE NEW GENERATION. | Drug-induced Nitrosogenesis/Carcinogenesis turns out to be a ubiquitous, pervasive, large-scale, poorly controllable concept for the academic community, which underlies the long-term, permanent modification of the human genome by contact with nitrosamines/NDSRIs, which ultimately leads to the generation of diverse cancers, but also melanoma in particular. The discovery of a (currently) unclassifiable number of nitroso derivatives/genome modifiers in the most commonly distributed drugs worldwide (in about 300 preparations according to the FDA/includes beta blockers/bisoprolol/nebivolol and ACE inhibitors/perindopril), their forced tolerability, attributed as a necessity or lack of alternative also to the present (but also to future periods), and their proven carcinogenicity (already 70 years ago), suggest a kind of creepy form of experiment to which public health is subjected worldwide. The creation of a universal nitroso-comfort of pharmaceutical companies and the regulation of a permanent intake of carcinogens in drugs for years to come, but also decades back, suggest possible cartel agreements between the regulation/distribution unit and that of production cycles. These "agreements" are becoming increasingly evident and in all likelihood position nitrosogenesis from a until recently unknown element, to a pathogenetic factor of paramount importance. Melanoma could be viewed precisely as the controlled end gene-modified product of drug-mediated nitrosogenesis/carcinogenesis, proven to be a locoregional (but not only) phenomenon hundreds if not thousands of times. The dilemma stays: Are the nitrosamines in drugs genetic weapons, ethnic bioweapons for silent war ? The nitrosogenesis concerning melanoma leads to the logical conclusion that cancer is in fact a largely controlled set event or, according to others, a forced necessity of evolutionary globalization processes to purge the population in certain regions. In favor of this statement indicative are namely: 1) lack of regulatory control/results of such conducted, 2) complete information veil for the end user regarding contamination with carcinogens/nitrosamines in certain batches or all batches of drugs, 3) misinformation and lack of transparency regarding the concept of nitrosogenesis also for the academic community, as well as 4) the impunity to pharmaceutical conglomerates after criminal negligence/controlled criminogenicity proven thousands of times by the FDA/EMA leading to regulatory controlled drug mediated genocide of the human population in certain areas on a daily basis. And most important of all: 5) the lack of refusal to eliminate these drugs, i.e. - the imposition of forced tolerance at any cost. It is extremely unfortunate that the mentioned and identified grotesque/situation, its tolerance on a global scale, lead to a misjudgement of the significance of real tumor inducers within the global health map//statistics as well as melanoma. The focus of prevention is being displaced, while the incidence of cancer in general and that of melanoma is skyrocketing. Nitrosamines could be defined as the newest, modern, until recently invisible and unknown, but -controllable form of genetic weapon to modify the human genome. Because of these very facts, the likelihood that clinicians and the academic community are in the frozen and permanent state of the Dunning-Kruger effect is very real. Certain globalization regulatory elements create problems and assignments that must be solved ˝competently˝ by incompetent, fully regulatable compartments. As their state of competence depends again and entirely on ˝their incompetence˝. Until now. After the formalization of the concept of Nitrosogenesis (as a form of genetic weapon) and melanoma for example, but not only, it remains to be seen whether universal incompetence will become a guarantee of competence and the survival. Or- will it remain again at the level of globalized, criminally conditioned, appointed and regulated from above "competent incompetence". The dilemmas to regulators and manufacturers remain open : Is it competent to take drugs that contain carcinogens/nitrosamines? Is it competent for this issue to continue for decades with impunity? Is it competent for regulators not to inform consumers about the presence of carcinogens/genome modifiers in medicines for decades? Is it competent for certain regions to be affected by nitrosamine contamination and not others? Is it competent not to reflect this in regional and global health bulletins on side effects? Is it competent to make thousands of times the profits from the modified genetic map business, regulated and legally initiated through the intake of carcinogens? Is it competent to have the concentration of carcinogens within polymedication exceeding many times the daily allowable doses of carcinogens and have no solution for this? Is it competent, when the intake of nitrosamines in medicines is associated with the generation of melanomas and heterogeneous cancers- to have no alternative to this or when one is available- to conceal it skillfully? Is it competent to determine carcinogenic activity based on mutagenic tests? Is it competent to be polyincompetent within a framework of mass (in)competence? We report systemically administered drugs for the treatment of high blood pressure from the group of beta blockers (bisoprolol/nebivolol) and ACE inhibitors (perindopril) that have been identified by regulators in the face of FDA as hypothetically contaminated with nitrosamines/NDSRIs with a carcinogenic potency between 4 and 5, respectively. Within this cumulative intake, (which according to the regulators was not at risk of developing cancerous forms), similar to other cases in the world literature, the patient developed a relatively short-term, metastatic nevus spilus-based nodular melanoma. The paper analyses not only the role of nitrosogenesis, but also that of two pregnancies and painful sunburns as potential cofactors for melanoma genesis. Academic attention is drawn to the potential impact of drug-mediated nitrosogenesis/carcinogenesis. Nitrosamines in the framework of polycontamination and polymedication could also be identified as one of the most effective, until recently unknown, modern generation genetic weapons for modifying the human genome and controlling cancer. Moreover, they could be controllably applied and skillfully targeted. At least until now. The officialization of carcinogens in more than 250 of the most common drugs and the clinico-pathological correlations concerning the development of cancer/melanoma in poorly controlled geographical regions represent a kind of in vivo prospective study to determine precisely the real carcinogenic role of nitrosamines to date. |
38096537 | AN INCREASED RISK OF HORMONAL DISORDERS, PRIMARILY DIABETES, IN INDIVIDUALS WITH Β -THALASSEMIA MAJOR: A RETROSPECTIVE ANALYSIS. | β-Thalassemia major is an inherited blood condition marked by a serious anemia and a lifetime need for blood transfusions. The effects of β-thalassemia major on endocrine health, notably the risk of diabetes, remain largely unstudied, despite the fact that its haematological components are established. The purpose of this systematic analysis was to examine the incidence of reduced metabolism of glucose in β--thalassemia major. The articles were under the inclusion requirements, after which the data was retrieved. The main outcome was determined to be every prevalence (P) of DM (diabetes mellitus) in β-thalassemia major. In order to examine the percentage of aberrant glucose metabolism (GM) with individuals among β-thalassemia major, the P with the 95% CI (Confidence Interval) was utilized. In this retrospective investigation, we looked at a cohort of people with β-thalassemia major diagnoses to determine the incidence and risk of hormonal diseases, particularly diabetes. A specialist thalassemia facility treated 315 individuals with β-thalassemia major, and their medical records were examined. Age, gender, age at which a main diagnosis of β-thalassemia was made, the length of transfusion treatment, and concomitant diseases were gathered as part of the demographic and clinical data. Our research, which included 17 studies and 1500 cases altogether, showed that with β -thalassemia major had a considerably greater frequency of diabetes than people in general. With a mean beginning age of 30 years, diabetes was identified in 28% of the research cohort's participants. The combined meta-analysis showed that each year had a rather stable level of DM P in β-thalassemia major. In people with major β-thalassemia, the P of impaired fasting glucose (IFG), DM, and impaired glucose tolerance (IGT) was 17.22% (95% CI: 8.44%-26.02%), (6.57 (95% CI: 5.31%- 7.79%) and 12.47 % (95% CI: 5.97%-18.95%), respectively. Our research suggests that people with β-thalassemia major have a high chance of acquiring diabetes, particularly if they get extended transfusion treatment. For prompt diagnosis and care, early detection of diabetes and other hormonal problems in this group is crucial. In β-thalassemia major, there is a high frequency of endocrine problems, including improper GM. To stop growth and endocrine issues, treatment and preventative measures can be required. |
38096538 | INNOVATIONS IN FOCUS: MECHANISTIC DISEASE THEORIES, CLIMATE DYNAMICS, AND HOST-PARASITE ADAPTATIONS. | Infectious illnesses are predicted to experience a range of intricate responses from climate change, with some likely to rise, others to fall and many expected to undergo changes in prevalence. The study uses extensive data on global temperature variations and infectious illness transmission in people and animals. We now know a lot more about how the temperature changes across the world and whether or not the spread of infectious diseases impacts people as well as animals. Three primary topics of research are investigated in this paper: improving mechanical disease modelling, investigating the role of environmental variation in sickness dynamics, and understanding the consequences of temperature imbalances between parasites and hosts. By incorporating the latest data stemming from these advancements into weather-disease models and bridging critical knowledge gaps, enhancing our ability to forecast the probable effect of rising temperatures on the prevalence of diseases among both human and animal communities is possible. Through the establishment of important information gaps and the incorporation of new findings into models of climate-disease relationships, it will be possible to predict the effects of changes in climatic averages, variations and extremes on people and wildlife health. |
38096539 | THE INCIDENCE OF SPORTS INJURIES AMONG SCHOOL-AGED CHILDREN AND ADOLESCENTS. | It is estimated that approximately one in ten school-aged children experience sports-related injuries annually. These injuries are most common at 12 years of age. Boys are more likely to get injured and more likely to get seriously injured than girls. The probability of injury is greater in contact or high-impact sports, with American soccer accounting for the largest number of injuries, followed by wrestling, basketball, soccer, and baseball. In certain sports, such as horseback riding, women are four times more likely to sustain injuries. The presented literature review details the incidence of various sports-related injuries in adolescents. Sports-related injuries observed in children under the age of 10 are nonspecific and include contusions, mild sprains, and fractures of the extremities, most commonly Salter-Harris fractures (growth plate fractures) or plastic fractures. In young athletes, sports-related injuries of the ligaments or muscles, as well as spinal or head injuries, are rare. This is particularly true during puberty, where growth plate fractures and musculoskeletal injuries occur more frequently. |
38096540 | EXPLORING MEDICAL STUDENTS' COMPETENCY IN UNDERSTANDING PRIMARY IMMUNODEFICIENCY DISEASES IN INDIA. | Primary Immunodeficiency Disease (PID) represents a class of diverse illnesses marked by compromised immune system performance. For better patient outcomes, PIDs must be diagnosed and treated quickly. Medical graduates are essential to the detection and treatment of these illnesses. The purpose of this study was to evaluate medical students' knowledge about PIDs in different Indian medical colleges. To perform this analytical investigation, college students from Maharashtra-area universities were enlisted between March and April of 2023. The participants received a questionnaire from mediators from every institution. Of the 500 students in the study, 66% were between the ages of 22 and 24 and 52% were female. Their understanding ratings had an average of 16.3±6.2 and varied between 4 and 32. A set of students classified as below average (86%) and a mean/above average (14%), were separated among the students. The largest percentage of above-average knowledge was demonstrated by VI-year participants (p<0.05). This investigation emphasizes how critical it is to provide focused educational activities to improve medical students' comprehension of PIDs in India. |
38096541 | AN INTRATENDINOUS GANGLION CYST OF THE PATELLAR TENDON: A RARE CAUSE OF ANTERIOR KNEE PAIN. | Ganglion cysts in the knee region can manifest as anterior knee pain. Unlike synovial cysts, these lesions lack synovial epithelial lining and occur secondary to mucoid degeneration of connective tissue because, often in response to chronic irritation and repetitive traumas. However, an intratendinous location is a rare finding. In the knee region, infrapatellar fat pad, the alar folds, and the anterior cruciate ligament are recognized to degenerate into ganglion. There are few case reports describing an involvement of the patellar tendon. We present the clinical case of a 72 years old male patient suffering from anterior knee pain attributed to an intratendinous ganglion cyst of the patellar tendon, obviously after a single traumatic event. After aspiration of the ganglion cyst the patient reported no complaints, and there has been no recurrence during the latest follow-up examination. |
38096542 | Toward Ablative SBRT for Nonmetastatic PDAC. | Combining a superoxide dismutase mimetic, avasopasem manganese, with stereotactic body radiation therapy may enable safe delivery of higher than standard radiation doses for patients with nonmetastatic, inoperable pancreatic adenocarcinoma. The phase Ib/II findings also suggest improved outcomes with avasopasem's addition, although the trial wasn't designed to compare arms and a larger study is needed. |
38096543 | Calculating the Circular Dichroism of Chiral Halide Perovskites: A Tight-Binding Approach. | Chiral metal halide perovskites have emerged as promising optoelectronic materials for the emission and detection of circularly polarized visible light. Despite chirality being realized by adding chiral organic cations or ligands, the chiroptical activity originates from the metal halide framework. The mechanism is not well understood, as an overarching modeling framework is lacking. Capturing chirality requires going beyond electric dipole transitions, which is the common approximation in condensed matter calculations. We present a density functional theory (DFT) parametrized tight-binding (TB) model, which allows us to calculate optical properties including circular dichroism (CD) at low computational cost. Comparing Pb-based chiral perovskites with different organic cations and halide anions, we find that the structural helicity within the metal halide layers determines the size of the CD. Our results mark an important step in understanding the complex correlations of structural, electronic, and optical properties of chiral perovskites and provide a useful tool to predict new compounds with desired properties for novel optoelectronic applications. |
38096545 | Mechanism and Stereoselectivity Control of Terminal Alkyne Dimerization Activated by a Zr/Co Heterobimetallic Complex: A DFT Study. | Heterobimetallic complexes have recently garnered considerable attention in organic synthesis owing to their high activity and selectivity, which surpass those of monometallic complexes. In this study, the detailed mechanisms of terminal alkyne dimerization activated by the heterobimetallic Zr/Co complex, as well as the different stereoselectivities of Me<sub>3</sub>SiC≡CH and PhC≡CH dimerization, were investigated and elucidated by using density functional theory calculations. After excluding the three-molecule reaction and outer-sphere mechanisms, the inner-sphere mechanism was determined as the most optimal process. The inner-sphere mechanism involves four processes: THF dissociation and coordination of the first alkyne; ligand migration and C-H activation; N<sub>2</sub> dissociation and insertion of the second alkyne; and reductive elimination. The stereoselectivity between the <i>E</i>-/<i>Z</i>- and <i>gem</i>-isomers is determined by the C-C coupling mode of the two alkynes and that of the <i>E</i>- and <i>Z</i>-isomers is determined by the sequence of the C-C coupling and hydrogen migration in the reductive elimination process. Me<sub>3</sub>SiC≡CH dimerization yields only an <i>E</i>-isomer owing to the large differences in the distortion and interaction energies, whereas PhC≡CH dimerization produces an <i>E</i>-, <i>Z</i>-, and <i>gem</i>-isomers owing to the reduced interaction energy differences. |
38096544 | Study on the Superlubricity Behavior of Ions under External Electric Fields at Steel Interfaces. | Realizing macroscopic superlubricity in the presence of external electric fields (EEFs) at the steel interfaces is still challenging. In this work, macroscopic superlubricity with a coefficient of friction value of approximately 0.008 was realized under EEFs with the lubrication of LiPF<sub>6</sub>-based ionic liquids at steel interfaces. The roles of cations and anions in the superlubricity realization under EEFs were studied. Based on the experimental results, the macroscopic superlubricity behavior of Li(PEG)PF<sub>6</sub> under EEFs at steel interfaces is attributed to the strong hydration effect of Li<sup>+</sup> cations and the complete reactions of anions that contributed to the formation of a boundary film on the appropriate surface. Moreover, the reduction in the number of iron oxides in the boundary film on the disc was beneficial for friction reduction. We also provide a calculation model to describe the relationship between the hydration effect and the optimal voltage position, at which the lowest friction might occur. Ultimately, this work proves that macroscopic superlubricity can be realized under EEFs at steel interfaces and provides a foundation for engineering applications of superlubricity in an electrical environment. |
38096546 | Vibrational Spectra of Highly Anharmonic Water Clusters: Molecular Dynamics and Harmonic Analysis Revisited with Constrained Nuclear-Electronic Orbital Methods. | Vibrational spectroscopy is widely used to gain insights into structural and dynamic properties of chemical, biological, and materials systems. Thus, an efficient and accurate method to simulate vibrational spectra is desired. In this paper, we justify and employ a microcanonical molecular simulation scheme to calculate the vibrational spectra of three challenging water clusters: the neutral water dimer (H<sub>4</sub>O<sub>2</sub>), the protonated water trimer (H<sub>7</sub>O<sub>3</sub><sup>+</sup>), and the protonated water tetramer (H<sub>9</sub>O<sub>4</sub><sup>+</sup>). We find that with the accurate description of quantum nuclear delocalization effects through the constrained nuclear-electronic orbital framework, including vibrational mode coupling effects through molecular dynamics simulations can additionally improve the vibrational spectrum calculations. In contrast, without the quantum nuclear delocalization picture, conventional <i>ab initio</i> molecular dynamics may even lead to less accurate results than harmonic analysis. |
38096547 | Cost-Effective Approach for Modeling of Multiresonant Thermally Activated Delayed Fluorescence Emitters. | Multiresonant thermally activated delayed fluorescence (MR-TADF) emitters have recently attracted great interest for application in organic light-emitting diodes due to their remarkable electroluminescent efficiency and narrow emission spectra. It is therefore essential to establish computational methodologies that can accurately model the excited states of these materials at manageable computational costs. With regard to MR-TADF design and their associated photophysics, previous works have highlighted the importance of wave function-based methods, at much higher computational costs, over the traditional time-dependent density functional theory approach. Herein, we employ two independent techniques built on different quantum mechanical frameworks, highly correlated wave function-based STEOM-DLPNO-CCSD and range-separated double hybrid density functional, TD-B2PLYP, to investigate their performance in predicting the excited state energies in MR-TADF emitters. We demonstrate a remarkable mean absolute deviation (MAD) of ∼0.06 eV in predicting Δ<i>E</i><sub>ST</sub> compared to experimental measurements across a large pool of chemically diverse MR-TADF molecules. Furthermore, both methods yield superior MAD in estimating S<sub>1</sub> and T<sub>1</sub> energies over earlier reported SCS-CC2 computed values [<i>J. Chem. Theory Comput.</i> <b>2022,</b> 18, 4903]. The short-range charge-transfer nature of low-lying excited states and narrow fwhm values, hallmarks of this class of emitters, are precisely captured by both approaches. Finally, we show the transferability and robustness of these methods in estimating rates of radiative and nonradiative events with adequate agreement against experimental measurements. Implementing these cost-effective computational approaches is poised to streamline the identification and evaluation of potential MR-TADF emitters, significantly reducing the reliance on costly laboratory synthesis and characterization processes. |
38096548 | Density Functional Theory and Raman Spectroscopy Studies of Adsorption Sites of Au Nanoparticles with Alectinib. | Alectinib is an ALK tyrosine kinase inhibitor, which is mainly used in patients with crizotinib-resistant nonsmall cell lung cancer. Alectinib has attracted much clinical attention for its longest progression-free survival time and the best therapeutic effect. The chemical adsorption of Au nanoclusters (AuNPs) with alectinib molecules is studied by density functional theory (DFT) and surface-enhanced Raman scattering spectroscopy (SERS) experiments. DFT/B3LYP-D3/6-311G** was used for optimization and vibration analysis of alectinib-Au<sub>6</sub> complexes, as well as molecular electrostatic potential, frontier molecular orbital, and electro-optic-based charge transfer descriptors. Comparing the results of the DFT theory and SERS experiment, alectinib and AuNPs can form Au-N6 bonds primarily through chemical adsorption of N6 atoms, and the experimental results showed that the enhancement factor (EFCHEM) could reach 4.27. The results provide a theoretical basis for exploring the mechanism of chemical enhancement between AuNPs and alectinib. |
38096549 | Carbon-Restricted Anoxic Zone as an Overlooked Anammox Hotspot in Municipal Wastewater Treatment Plants. | The anoxic zone serves as the core functional unit in municipal wastewater treatment plants (MWWTPs). Unfortunately, in most cases, the downstream range of the anoxic zone is severely lacking in available organic carbon and thus contributes little to the removal of nutrients. This undesirable range is termed the "carbon-restricted anoxic zone", representing an insurmountable drawback for traditional MWWTPs. This study uncovers a previously overlooked role for the carbon-restricted anoxic zone: a hotspot for anaerobic ammonium oxidation (anammox). In a continuous-flow pilot-scale plant treating municipal wastewater (55 m<sup>3</sup>/d), virgin biocarriers were introduced into the carbon-restricted anoxic zone (downstream 25% of the anoxic zone with BOD<sub>5</sub> of 5.9 ± 2.3 mg/L). During the 517-day monitoring, anammox bacteria highly self-enriched within the biofilms, with absolute and relative abundance reaching up to (9.4 ± 0.1) × 10<sup>9</sup> copies/g-VSS and 6.17% (<i>Candidatus</i> Brocadia), respectively. <sup>15</sup>N isotopic tracing confirmed that anammox overwhelmingly dominated nitrogen metabolism, responsible for 92.5% of nitrogen removal. Following this upgrade, the contribution ratio of the carbon-restricted anoxic zone to total nitrogen removal increased from 9.2 ± 4.1% to 19.2 ± 4.2% (<i>P</i> < 0.001), while its N<sub>2</sub>O emission flux decreased by 84.5% (<i>P</i> < 0.001). These findings challenge stereotypes about the carbon-restricted anoxic zone and highlight the multiple environmental implications of this newfound anammox hotspot. |
38096551 | The Changing Winds of Academic Publishing and O&G Open. | |
38096552 | Routine Pelvic Examinations and the Ethics of Screening. | |
38096550 | Food and Aeroallergen Sensitization, Eosinophils Levels and Risk of Atopic Dermatitis in Abuja. | The barrier dysfunction of atopic dermatitis (AD) promotes epicutaneous sensitization to aeroallergens. This study aimed to evaluate the prevalence of food and aeroallergen sensitization in AD and to explore the relationship between allergen sensitization and the personal or family history of allergic rhinitis, conjunctivitis, asthma, eosinophil count, and AD severity of Nigerian patients. |
38096553 | American Employers Have Discretion to Influence Maternal Health. | |
38096555 | ACOG Publications: January 2024. | |
38096554 | Coronavirus Disease 2019 (COVID-19) and Venous Thromboembolism During Pregnancy and Postpartum. | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with increased risk for macro- and micro-thrombi. Consensus guidelines recommend use of thromboprophylaxis in nonobstetric patients with SARS-CoV-2 infection admitted to the hospital. National-level studies evaluating venous thromboembolism (VTE) among pregnant and postpartum individuals with and without SARS-CoV-2 infection have not been completed. We performed a retrospective cohort study of individuals aged 18 years or older delivering at more than 20 weeks of gestation with data in the MarketScan Commercial Insurance Database from 2016 through 2020. Of 811,008 deliveries, SARS-CoV-2 infection during pregnancy or through 6 weeks postpartum was associated with increased risk for VTE compared with no infection (1.0% vs 0.5%, adjusted hazard ratio 2.62, 95% CI 1.60-4.29). Findings support further consideration of thromboprophylaxis in the obstetric population with SARS-CoV-2 infection. |
38096557 | Chronic Hypertension in Pregnancy and Racial-Ethnic Disparities in Complications. | |
38096556 | First and Second Stage Labor Management: ACOG Clinical Practice Guideline No. 8. | The purpose of this document is to define labor and labor arrest and provide recommendations for the management of dystocia in the first and second stage of labor and labor arrest. |
38096558 | In Reply. | |
38096559 | ACOG Clinical Consensus No. 3: General Approaches to Medical Management of Menstrual Suppression: Correction. | |
38096561 | Combined Bilateral Salpingo-oophorectomy and Cesarean Delivery in BRCA1/2 Alteration Carriers: A Case Series: Correction. | |
38096560 | Radiofrequency Ablation of Leiomyomas: Correction. | |
38096562 | Association of Radical Hysterectomy Surgical Volume and Survival for Early-Stage Cervical Cancer: Correction. | |
38096563 | DAPD Set of Pd-Containing Diatomic Molecules: Accurate Molecular Properties and the Great Lengths to Obtain Them. | In the present study, we obtained reliable bond energy, bond length, and zero-point vibrational frequency for a set of diatomic Pd species (the DAPD set). It includes PdH, Pd<sub>2</sub>, and PdX (X = B, C, N, O, F, Al, Si, P, S, and Cl). Our highest-level protocol (W4X-L) represents scalar and spin-orbit relativistic, valence- and inner-valence correlated, extrapolated CCSDTQ(5) energy. The DAPD set of molecules is challenging for computational chemistry methods in different manners; for Pd<sub>2</sub>, the spin-orbit contribution to the bond energy is fairly large, whereas for PdC and PdSi, the post-CCSD(T) correlation components are considerable. The diverse range of requirements represents a significant challenge for lower-level methods. While density functional theory (DFT) methods generally yield good agreements for bond lengths and vibrational frequencies, large deviations are found for bond energies. In general, hybrid DFT methods are more accurate than nonhybrid functionals, but the agreement in individual cases varies. This illustrates the critical role that new high-quality reference data would play in the continual development of lower-cost methods. |
38096564 | From the archives: Evolutionary origins of Delphinieae flowers, pseudogenes, and the light-responsive localization of COP1. | |
38096565 | Impact of thermal desorption tubes on the variability of exhaled breath data. | Due to the overall low abundance of volatile compounds in exhaled breath, it is necessary to preconcentrate the sample prior to traditional thermal desorption gas chromatography mass spectrometry (TD-GC-MS) analysis. While certain aspects of thermal desorption tubes, such as volatile storage, have been evaluated, many aspects remain uncharacterized. Two common thermal desorption tubes, Tenax TA and Biomonitoring 5TD tubes, were evaluated for background content and flow rate variability. The data illustrate that the Biomonitoring 5TD tubes have the highest number (23) and abundance of background contamination greater than 3x the mean noise when compared to Tenax TA (13) and empty tubes (9). Tentative identifications of the compounds in the background contamination experiment show that greater than 59% (16/27) of the compounds identified have been reported in the breath literature. The data illustrate the TD tube background abundance could account for more than 70% of the chromatographic signal from exhaled breath for these select compounds. Flow rate measurements of 200 Tenax TA and 200 Biomonitoring 5TD tubes show a large range in measured flow rates among the TD tubes (Tenax: 252.9-284.0mL min-1, 5TD: 220.6-255.1mL min-1). Finally, TD tubes of each type, Tenax TA and Biomonitoring 5TD, previously established to have high, medium, and low flow rates, show insignificant differences (p>0.05) among the tubes of different flow rates, using both gas standards and an exhaled breath from a peppermint experiment. Collectively, these results establish overall background compounds attributed to each TD tube type tested. Additionally, while measured flow rate variability is present and plausibly impacts exhaled breath results, the data demonstrate no statistically significant difference was observed between tubes showing high, medium, and low flow rates from two separate sample types. |
38096566 | Correction to: Chromosome-Level Assemblies of the Pieris mannii Butterfly Genome Suggest Z-Origin and Rapid Evolution of the W Chromosome. | |
38096567 | Mapping Single-Molecule Protein Complexes in 3D with DNA Nanoswitch Calipers. | The ability to accurately map the 3D geometry of single-molecule complexes in trace samples is a challenging goal that would lead to new insights into molecular mechanics and provide an approach for single-molecule structural proteomics. To enable this, we have developed a high-resolution force spectroscopy method capable of measuring multiple distances between labeled sites in natively folded protein complexes. Our approach combines reconfigurable nanoscale devices, we call DNA nanoswitch calipers, with a force-based barcoding system to distinguish each measurement location. We demonstrate our approach by reconstructing the tetrahedral geometry of biotin-binding sites in natively folded streptavidin, with 1.5-2.5 Å agreement with previously reported structures. |
38096568 | Formation and characterization of Group IV semiconductor nanowires. | To enable the application to next-generation devices of semiconductor nanowires (NWs), it is important to control their formation and tune their functionality by doping and the use of heterojunctions. In this paper, we introduce formation and the characterization methods of nanowires, focusing on our research results. We describe a top-down method of controlling the size and alignment of nanowires that shows advantages over bottom-up growth methods. The latter technique causes damage to the nanowire surfaces, requiring defect removal after the NW formation process. We show various methods of evaluating the bonding state and electrical activity of impurities in NWs. If an impurity is doped in a NW, mobility decreases due to the scattering that it causes. As a strategy for solving this problem, we describe research into core-shell nanowires, in which Si and Ge heterojunctions are formed in the diameter direction inside the NW. This structure can separate the impurity-doped region from the carrier transport region, promising as a channel for the new ultimate high-mobility transistor. |
38096569 | A denoising method based on deep learning for proton radiograph using energy resolved dose function. | Proton radiograph has been broadly applied in proton radiotherapy which is affected by scattered protons which result in the lower spatial resolution of proton radiographs than that of X-ray images. Traditional image denoising method may lead to the change of water equivalent path length (WEPL) resulting in the lower WEPL measurement accuracy. In this study, we proposed a new denoising method of proton radiographs based on energy resolved dose function (ERDF) curves.
Approach: Firstly, the corresponding relationship between the distortion of WEPL characteristic curve, and energy and proportion of scattered protons was established. Then, to improve the accuracy of proton radiographs, deep learning technique was used to remove scattered protons and correct deviated WEPL values. Experiments on a calibration phantom to prove the effectiveness and feasibility of this method were performed. In addition, an anthropomorphic head phantom was selected to demonstrate the clinical relevance of this technology and the denoising effect was analyzed.
Main results: The curves of WEPL profiles of proton radiographs became smoother and deviated WEPL values were corrected. For the calibration phantom proton radiograph, the average absolute error (MAE) of WEPL values decreased from 2.23 to 1.72, the mean percentage difference of all materials of relative stopping power (RSP) decreased from 1.24 to 0.39, and the average relative WEPL corrected due to the denoising process was 1.06%. In addition, WEPL values correcting were also observed on the proton radiograph for anthropomorphic head phantom due to this denoising process.
Significance: The experiments showed that this new method was effective for proton radiograph denoising and had greater advantages than end-to-end image denoising methods, laying the foundation for the implementation of precise proton radiotherapy.
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38096571 | Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment. | Analysis of mutational signatures is a powerful approach for understanding the mutagenic processes that have shaped the evolution of a cancer genome. To evaluate the mutational signatures operative in a cancer genome, one first needs to quantify their activities by estimating the number of mutations imprinted by each signature. |
38096572 | Facile preparation of small-sized gold nanoparticle decorated silica nanocomposites and their morphological changes in catalytic reactions. | Due to the unique physicochemical properties of gold nanoparticles (AuNPs) decorated silica nanostructures (SiO2@AuNPs), they show great potential for applications in catalysis, biosensing, optical devices and medicine. It is essential to explore the catalytic effect of SiO2@AuNPs and the understanding of the essential process of catalytic reactions. We have prepared SiO2@AuNPs by loading small-sized AuNPs on surface-modified silica nanospheres. SiO2@AuNPs was used as a catalyst for the catalytic reduction of 4-nitrophenol (4-NP) in the presence of excess NaBH4, and the results showed that with the increase of the amount of catalyst from 30 µL to 100 µL, the corresponding rate constant Kapp was increased from 6.44×10-3 s-1 to 1.45×10-2 s-1, and its TOF was as high as 1.326 × 103 h-1, and the catalytic rate could still be maintained at 87% after five cycles. By analyzing the morphology and size of the SiO2 supported AuNPs before and after the catalytic reaction, it can be seen that the atoms on the surface of small-sized AuNPs supported by silica have migrated during the catalytic process, which subsequently affects the catalytic efficiency of the structure. This study proves the good catalytic effect of SiO2@AuNPs structure and lays the foundation for its wider application. |
38096570 | Symptomatic Upper Extremity Peripheral Artery Disease is Associated With Poor Outcomes and a Broad Spectrum of Etiologies. | The symptomatic upper extremity peripheral artery disease (sUE-PAD) is poorly studied compared with the lower extremity peripheral artery disease (LE-PAD). We aimed to describe sUE-PAD etiologies and outcomes at 2 years. From an observational survey conducted in two French tertiary hospitals, demographic characteristics, etiology, treatment, and outcomes during follow-up were collected on patients with ICD-10 I74.2 code (arterial thrombosis of the upper limbs). We identified 181 patients (53% male, 55 ± 17 years) with hypothenar hammer syndrome (13.8%), cardioembolism (13.3%), atheroma (12.7%), or connective tissue disease (10.5%). No etiology could be found for 16.0% of them. The amputation rate was 13.3%, and lasting symptoms remained at 21.3%. During follow-up, atrial fibrillation occurred in 1 patient and cancer in 4. At 2 years, 59 patients were lost to follow-up, 110 patients were alive, and 12 patients had died. Age and cancer were associated with death. sUE-PAD is not benign, with 20% impaired upper extremity outcome and 10% overall mortality at 2 years. Less frequent than LE-PAD, sUE-PAD presents different characteristics: more women, younger age, and a broad spectrum of etiologies. sUE-PAD requires thorough etiological assessment and is considered to be associated with a severe overall prognosis. |
38096573 | An assessment of worker exposure to respirable dust and crystalline silica in workshops fabricating engineered stone. | There is a significant silicosis risk for workers fabricating engineered stone (ES) products containing crystalline silica. The aims of this study by SafeWork NSW were to: (i) assess current worker exposure to respirable dust (RD) and respirable crystalline silica (RCS) following a 5-y awareness and compliance program of inspections in ES workshops and (ii) to identify improvements in work practices from the available evidence base to further reduce exposures. One hundred and twenty-three personal full shift samples taken on as many workers and 34 static samples across 27 workshops fabricating ES were included in the final assessment. The exposure assessment was conducted using Casella Higgins-Dewell cyclones (Casella TSI) placed in the breathing zone of workers attached to SKC Air Check XR 5000 or SKC Chek TOUCH sampling pumps. Sample filters were sent to an ISO (2017) 17025:2017 accredited laboratory for gravimetric analysis for RD and X-Ray Diffraction (XRD) analysis to determine the amount of deposited RCS i.e. alpha-quartz and cristobalite. All workshops used wet methods of fabrication. The geometric mean (GM) of the pooled result for respirable dust (RD) was 0.09 mg/m3 TWA-8 h and 0.034 mg/m3 TWA-8 h for RCS. The highest exposed workers with a GM RCS of 0.062 mg/m3 TWA-8 h were those using pneumatic hand tools for cutting or grinding combined with polishing tasks. Workers operating semiautomated routers and edge polishers had the lowest GM RCS exposures of 0.022 mg/m3 TWA-8 h and 0.018 mg/m3 TWA-8 h respectively. Although ES workers remain exposed to RCS above the workplace exposure limit (WEL) of 0.05 mg/m 3 TWA-8 h, these results point to a very substantial reduction in exposures compared to poorly controlled dry methods of fabrication. Therefore, the wearing of respiratory protection by workers remains necessary until further control measures are more widely adopted across the entire industry e.g. reduction in the crystalline silica content of ES. |
38096574 | Dual Stimulus-Responsive Enzyme@Metal-Organic Framework-Polymer Composites toward Enhanced Catalytic Performance for Visual Detection of Glucose. | Enzyme immobilization on a metal-organic framework (enzyme@MOF) has been proven to be a promising strategy for boosting catalysis and biosensing applications. However, promoting the catalytic performance of polymer-modified enzyme@MOF composites remains an ongoing challenge. Herein, a protocol for enzyme immobilization was designed by using a smart polymer-modified MOF (UiO-66-NH<sub>2</sub>, UN) as the support. Through in situ polymerization, the dual stimulus-responsive poly(<i>N</i>-2-dimethylamino ethyl methacrylate) (PDM) was prepared. The PDM as a "soft cage" protected the immobilized glucose oxidase (GOx)-horseradish peroxidase (HRP) on the surface of the rigid UN. The confinement effect was generated by varying the temperature and pH, thereby improving the catalytic activity of the GOx-HRP@UN-PDM composites. In comparison with free enzymes, the fabricated composites exhibited an 8.9-fold enhancement in catalytic performance (<i>V</i><sub>max</sub>) at pH 5.0 and 49 °C. Furthermore, relying on a cascade reaction generated in the composites, an assay was developed for the visual detection of glucose in rat serum. This study introduces a groundbreaking approach for the construction of smart enzyme@MOF-polymer composites with high catalytic activity for sensitive monitoring of biomolecules. |
38096576 | Direct growth Bi2O2Se nanosheets on SiO2/Si substrate for high-performance and broadband photodetector. | Bi2O2Se, a newly emerging two-dimensional (2D) material, has attracted significant attention as a promising candidate for optoelectronics applications due to its exceptional air stability and high mobility. Generally, mica and SrTiO3 substrates with lattice matching are commonly used for the growth of high-quality 2D Bi2O2Se. Although 2D Bi2O2Se grown on these insulating substrates can be transferred onto SiO2/Si substrate to ensure compatibility with silicon-based semiconductor processes, this process inevitably introduces technical challenges and additional defects that could potentially compromise the performance of optoelectronic devices. Here we report the direct growth of Bi2O2Se nanosheets on the SiO2/Si substrate. The photodetector based on the grown Bi2O2Se nanosheets demonstrates outstanding optoelectronics performance with a responsivity of 379 A W-1, detectivity of 2.9×1010 Jones, and rapid response time of 290 μs under 532 nm illumination. Furthermore, it demonstrates a broadband photodetection capability spanning from the visible to near-infrared range (532 nm to 1300 nm). These results indicate the promising potential of Bi2O2Se nanosheets for high-performance and broadband photodetector applications. |
38096577 | Significant thermal rectification induced by phonon mismatch of functional groups in a single-molecule junction. | Single-molecule junctions may bring exotic physical effects. In this work, a significant thermal rectification effect is observed in a cross-dimensional system, comprising a diamond, a single-molecule junction, and a carbon nanotube (CNT). The molecular dynamics (MD) simulations indicate that the interfacial thermal resistance varies with the direction of heat flow, the orientation of the crystal planes of the diamond, and the length of the CNT. We find that the thermal rectification ratio escalates with the length of the CNT, achieving a peak value of 730 % with the CNT length of 200 nm. A detailed analysis of phonon vibrations suggests that the primary cause of thermal rectification is the mismatched vibrations between the biphenyl and carbonyl groups. This discovery may offer theoretical insights for both the experimental exploration and practical application of single-molecule junctions in efficient thermal management strategy for high power and highly integrated chips.
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38096575 | Distribution of regional lung function in upright healthy subjects determined by electrical impedance tomography in two chest examination planes. | <i>Objective</i>.&#xD;The variation in pulmonary gas content induced by ventilation is not uniformly distributed in the lungs. The aim of our study was to characterize the differences in spatial distribution of ventilation in two transverse sections of the chest using electrical impedance tomography (EIT).&#xD;<i>Approach</i>.&#xD;Twenty adult never-smokers, 10 women and 10 men (mean age ± SD, 31 ± 9 years), were examined in a sitting position with the EIT electrodes placed consecutively in a caudal (6th intercostal space) and a cranial (4th intercostal space) chest location. EIT data were acquired during quiet breathing, slow and forced full expiration manoeuvres. Impedance variations representing tidal volume (V<sub>T</sub>), vital capacity (VC), forced expiratory volume in 1 s (FEV<sub>1</sub>) and forced vital capacity (FVC) were calculated at the level of individual image pixels and their spatial distribution was determined using the following EIT measures: the centres of ventilation in ventrodorsal (CoV<sub>vd</sub>) and right-to-left direction (CoV<sub>rl</sub>), the dorsal and right fractions of ventilation, the coefficient of variation (CV) and the global inhomogeneity (GI) index.&#xD;<i>Main results</i>.&#xD;The sums of pixel ventilation-related impedance variations reproduced reliably the volumetric dissimilarities among V<sub>T</sub>, VC, FEV<sub>1</sub>and FVC, with no significant differences noted between the two examination planes. Significant differences in ventilation distribution were found between the planes during tidal breathing and slow full expiration, mainly regarding the ventrodorsal direction, with higher values of CoV<sub>vd</sub>and dorsal fraction of ventilation in the caudal plane (p<0.01). No significant differences in the spatial distribution of FEV<sub>1</sub>and FVC were detected between the examination planes. &#xD;<i>Significance</i>. &#xD;The spatial distribution of ventilation differed between the two examination planes only during the relaxed (quiet breathing and slow VC manoeuvre) but not during the forced ventilation. This effect is attributable to the differences in thoracoabdominal mechanics between these types of ventilation.&#xD. |
38096578 | M11pz: A Nonlocal Meta Functional with Zero Hartree-Fock Exchange and with Broad Accuracy for Chemical Energies and Structures. | The accuracy of Kohn-Sham density functional theory depends strongly on the approximation to the exchange-correlation functional. In this work, we present a new exchange-correlation functional called M11pz (M11 <u>p</u>lus rung-3.5 terms with <u>z</u>ero Hartree-Fock exchange) that is built on the M11plus functional with the goal of using its rung-3.5 terms without a Hartree-Fock exchange term, especially to improve the accuracy for strongly correlated systems. The M11pz functional is optimized with the same local and rung-3.5 ingredients that are used in M11plus but without any percentage of Hartree-Fock exchange. The performance of M11pz is compared with eight local functionals, and M11pz is found to be in top three when the errors or ranks are averaged over eight grouped and partially overlapping databases: AME418/22, atomic and molecular energies; MGBE172, main-group bond energies; TMBE40, transition-metal bond energies; SR309, single-reference systems; MR54, multireference systems; BH192, barrier heights; NC579, noncovalent interaction energies; and MS20, molecular structures. For calculations of band gaps of solids, M11pz is the second best of the nine tested functionals that have zero Hartree-Fock exchange. |
38096579 | Active-parameter polydispersity in the 2d ABP Yukawa model. | In both experiments and simulations the most commonly studied kind of parameter polydispersity is that of varying particles size. This paper investigates by simulations the effects of introducing polydispersity in other parameters for two-dimensional Active Brownian Particles with Yukawa pair interactions. Polydispersity is studied separately in the translational and rotational diffusion coefficients, as well as in the swim velocity $v_0$. Uniform and binary parameter distributions are considered in both the homogeneous and the motility-induced phase-separation (MIPS) phases. We find only minute changes in structure and dynamics upon the introduction of parameter polydispersity, even for situations involving 50\% polydispersity. The reason for this is not clear. An exception is the case of $v_0$ polydispersity for which the average radial distribution function with changing polydispersity shows significant variations in the MIPS phase. Even in this case, however, the dynamics is only modestly affected. As a possible application of our findings, we suggest that a temporary introduction of polydispersity into a single-component active-matter model characterized by a very long equilibration time, i.e., a glass-forming active system, may be used to equilibrate the system efficiently by particle swaps. |
38096580 | Improving the targeted delivery of curcumin to esophageal cancer cells via a novel formulation of biodegradable lecithin/chitosan nanoparticles with downregulated miR-20a and miR-21 expression. | Nanoencapsulation, employing safe materials, holds substantial promise for enhancing bioactive compounds' delivery, stability, and bioactivity. In this study, we present an innovative and safe methodology for augmenting the incorporation of the anticancer agent, curcumin, thereby inducing apoptosis by downregulating miR20a and miR21 expression. Our established methodology introduces three pivotal elements that, to our knowledge, have not undergone formal validation: 1) Novel Formulation: We introduce a unique formula for curcumin incorporation. 2) Biocompatibility and Biodegradability: Our formulation exclusively consists of biocompatible and biodegradable constituents, ensuring the absence of detrimental residues or undesirable reactions under varying conditions. 3) Low-Temperature Incorporation: Curcumin is incorporated into the formulation at temperatures approximating 50°C. The formulation comprises lecithin (LE), chitosan (CH), an eco-friendly emulsifying agent, and olive oil as the solvent for curcumin. Nanoscale conversion is achieved through ultrasonication and probe sonication (20 kHz). Transmission electron microscopy (TEM) reveals spherical nanoparticles with diameters ranging from 29.33 nm and negative zeta potentials within the -28 to -34 mV range. Molecular studies involve the design of primers for miR20a and miR21. Our findings showcase a remarkable encapsulation efficiency of 91.1% for curcumin, as determined through a linear equation. The curcumin-loaded nanoformulation demonstrates potent anticancer activity, effectively activating the apoptosis pathway in cancer cells at the minimum inhibitory concentration. These results underscore the potential of our nanoformulation as a compelling, cancer-selective treatment strategy, preserving the integrity of normal cells, and thus, warranting further exploration in the field of cancer therapy. |
38096581 | First-principles study of thermodynamic stability and mechanical properties of fifteen high-entropy quaternary metal disilicides. | By combining first-principles density-functional calculations and thermodynamics, we investigated the thermodynamic stability and mechanical properties of 15 quaternary high-entropy metal disilicides composed of silicon and four of the six refractory transition metals Ti, Zr, Hf, V, Nb, and Ta. We constructed a three-dimensional diagram specified by two thermodynamic parameters (the mixing enthalpy and the ratio of the entropy term in the Gibbs free energy to enthalpy) and a structural parameter (the lattice size difference). The obtained diagram allows us to predict that, except for TiZrHfVSi<sub>8</sub>, the formation of all other fourteen single-phase metal disilicides is thermodynamically favorable. Our calculations show that, for the formation of each of the 14 metal disilicides, the driving force suppresses the resistance at temperatures well below the melting point, suggesting that it is feasible to synthesize these high-entropy materials. One of these (TiHfNbTaSi<sub>8</sub>) has already been experimentally realized. Furthermore, the values of the mechanical parameters and melting points of the predicted fourteen quaternary high-entropy metal disilicides are all greater than the corresponding average values of the four single-metal disilicides.&#xD. |
38096582 | Phase transformations in single-layer MoTe<sub>2</sub>stimulated by electron irradiation and annealing. | Among two-dimensional (2D) transition metal dichalcogenides (TMDs), MoTe<sub>2</sub>is predestined for phase-engineering applications due to the small difference in free energy between the semiconducting H-phase and metallic 1T'-phase. At the same time, the complete picture of the phase evolution originating from point defects in single-layer of semiconducting H-MoTe<sub>2</sub>via Mo<sub>6</sub>Te<sub>6</sub>nanowires to cubic molybdenum has not yet been reported so far, and it is the topic of the present study.&#xD;The occurring phase transformations in single-layer H-MoTe<sub>2</sub>were initiated by 40-80 kV electrons in the spherical and chromatic aberration-corrected high-resolution transmission electron microscope and/or when subjected to high temperatures.&#xD;We analyse the damage cross-section at voltages between 40-80 kV and relate the results to previously published values for other TMDs. Then we demonstrate that electron beam irradiation offers a route to locally transform freestanding single-layer H-MoTe<sub>2</sub>into one-dimensional (1D) Mo<sub>6</sub>Te<sub>6</sub>nanowires. Combining the experimental data with the results of first-principles calculations, we explain the transformations in MoTe<sub>2</sub>single-layers and Mo<sub>6</sub>Te<sub>6</sub>nanowires by an interplay of electron-beam-induced energy transfer, atom ejection, and oxygen absorption. Further, the effects emerging from electron irradiation are compared with those produced by in situ annealing in a vacuum until pure molybdenum crystals are obtained at temperatures of about 1000°C. A detailed understanding of high-temperature solid-to-solid phase transformation in the 2D limit can provide insights into the applicability of this material for future device fabrication.&#xD. |
38096583 | Clinical heterogeneity and prognostic factors of anti-synthetase syndrome: a multi-centered retrospective cohort study. | Anti-synthetase syndrome (ASyS) patients have heterogeneous clinical manifestations with different initial presentations, complications, and outcomes. This study aimed to assess the clinical characteristics and complications in patients with ASyS, and to identify factors that were associated with the survival of ASyS patients. |
38096584 | Interdisciplinary Cardiovascular and Thoracic Surgery-Case Report An Atypical Airway Cast. | A 60-year-old man intubated for airway protection after smoke inhalation, was found to have decompensated hypercapnic respiratory failure. Fiberoptic bronchoscopy revealed obstructive airway slough and pseudomembrane, a manifestation of severe inhalation injury. Venovenous extracorporeal membrane oxygenation (VV-ECMO) was established for stabilization. The airway casts were removed successfully with periprocedural VV-ECMO support. |
38096585 | Clumppling: cluster matching and permutation program with integer linear programming. | In the mixed-membership unsupervised clustering analyses commonly used in population genetics, multiple replicate data analyses can differ in their clustering solutions. Combinatorial algorithms assist in aligning clustering outputs from multiple replicates, so that clustering solutions can be interpreted and combined across replicates. Although several algorithms have been introduced, challenges exist in achieving optimal alignments and performing alignments in reasonable computation time. |
38096586 | Purpose in Life Links Positive Aging Views to Life Satisfaction: A Within-Person Analysis Spanning 13 Years. | This study aimed to examine the relationship between positive perceptions of aging, purpose in life, and life satisfaction in older adults. It was hypothesized that purpose in life mediates the relationship between positive perceptions of one's aging and life satisfaction. This hypothesis was tested in a sample of older American adults from four waves of the Health and Retirement Study collected at 4-year intervals between 2008 and 2020 (<i>N</i> = 11,546, mean age in 2008 = 62.772). The random intercept cross-lagged panel model was used to separate within-person and between-person sources of variance. Mediation was tested at the longitudinal within-person level and was supported. Results suggest that an increase in positive perceptions of aging is associated with a future increase in purpose in life, which in turn is associated with higher future levels of life satisfaction. The findings inform interventions promoting positive aging, purpose, and life satisfaction in older adults. |
38096587 | Tricuspid valve disease and cardiac implantable electronic devices. | The role of cardiac implantable electronic device (CIED)-related tricuspid regurgitation (TR) is increasingly recognized as an independent clinical entity. Hence, interventional TR treatment options continuously evolve, surgical risk assessment and peri-operative care improve the management of CIED-related TR, and the role of lead extraction is of high interest. Furthermore, novel surgical and interventional tricuspid valve treatment options are increasingly applied to patients suffering from TR associated with or related to CIEDs. This multidisciplinary review article developed with electrophysiologists, interventional cardiologists, imaging specialists, and cardiac surgeons aims to give an overview of the mechanisms of disease, diagnostics, and proposes treatment algorithms of patients suffering from TR associated with CIED lead(s) or leadless pacemakers. |
38096588 | IntelliGenes: A novel machine learning pipeline for biomarker discovery and predictive analysis using multi-genomic profiles. | In this article, we present IntelliGenes, a novel machine learning (ML) pipeline for the multi-genomics exploration to discover biomarkers significant in disease prediction with high accuracy. IntelliGenes is based on a novel approach, which consists of nexus of conventional statistical techniques and cutting-edge ML algorithms using multi-genomic, clinical, and demographic data. IntelliGenes introduces a new metric i.e., Intelligent Gene (I-Gene) score to measure the importance of individual biomarkers for prediction of complex traits. I-Gene scores can be utilized to generate I-Gene profiles of individuals to comprehend the intricacies of ML used in disease prediction. IntelliGenes is user-friendly, portable, and a cross-platform application, compatible with Microsoft Windows, macOS, and UNIX operating systems. IntelliGenes not only holds the potential for personalized early detection of common and rare diseases in individuals, but also opens avenues for broader research using novel ML methodologies, ultimately leading to personalized interventions and novel treatment targets. |
38096589 | Field-induced Bose-Einstein condensation in zigzag spin chain KGaCu(PO<sub>4</sub>)<sub>2</sub>. | Single crystals of GaKCu(PO4)2 were synthesized using the hydrothermal method, and subsequent measurements of specific heat, magnetic susceptibility, and high-field magnetization were performed. A broad peak is observed in the magnetic susceptibility and specific heat curves, with the maximum values appearing at about 11.5 K and 5.29 K, respectively. The highest maximum peak value of susceptibility is observed when the magnetic field is applied along the c-axis, followed by the a-axis, b-axis, and polycrystalline samples. These indicate that the system exhibits one-dimensional magnetism and the magnetic easy axis is the c axis. The magnetization at 2 K reveals the occurrence of a field-induced Bose-Einstein condensation (BEC) phase within the magnetic field range of approximately 8-12 T. High-field magnetization up to 40 T indicates that the compound reaches magnetization saturation as the field exceeds Hs = 12 T. Through systematic measurements, a field-temperature (H-T) phase diagram was constructed, and dome-like phase boundaries were observed. The findings suggest that GaKCu(PO4)2 is a spin gap system and a promising candidate for studying BEC of magnons due to its phase transition boundary occurring at low magnetic fields.
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