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525480525+-0528-1.layout.json | [
"88",
"V.",
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":",
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"VIII,",
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"2.",
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"1965b).",
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"to",
"or",
"polen-",
"of",
"other",
"antihypertensive",
"drugs;",
"po-",
"occurs",
"with",
"ganglionic",
"or",
"penpheral",
"blocking",
"dmfs.",
"ensitivity",
"reactions",
"may",
"oteur",
"in",
"patients",
"with",
"a",
"history",
"of",
"allergy",
"or",
"ssthma.",
"Possibility",
"of",
"exacerbation",
"or",
"achivation",
"of",
"systemic",
"lupus",
"erythematosus",
"has",
"been",
"reported.",
"Usage",
"in",
"prepronty:",
"Thiazides",
"cross",
"plocental",
"bar-",
"vier",
"and",
"aprear",
"in",
"cotd",
"blood:",
"in",
"prananc{",
"o",
"in",
"womon",
"of",
"childbeating",
"potential,",
"weigh",
"antict-",
"ated",
"benefit",
"ageinat",
"possible",
"hazards,",
"thclugin",
"etal",
"or",
"neonatal",
"jaundice,",
"thrombocytopenis,",
"an",
"omim{",
"other",
"adverse",
"teactions",
"thet",
"have",
"oo",
"curted",
"in",
"adults,",
"Nursing",
"mothers:",
"Thintides",
"appear",
"in",
"breast",
"milk;",
"it",
"use",
"of",
"drug",
"is",
"ceemed",
"essential,",
"patient",
"should",
"stop",
"nursing.",
".",
"Precautions:",
"Perform",
"periodic",
"determination",
"af",
"setum",
"electrolytes",
"to",
"detect",
"possidle",
"elactrolyte",
"imbalance.",
"Observe",
"all",
"patients",
"for",
"clinical",
"signs",
"of",
"fluid",
"or",
"elecleolyte",
"imbalence,",
"namely,",
"hyc:",
"nairemis,",
"hypochloremic",
"atkelosis,",
"ond",
"hypoke-",
"lemia.",
"Serum",
"and",
"urine",
"electiolyte",
"determinations",
"are",
"particularly",
"important",
"when",
"patient",
"is",
"vomil-",
"ing",
"excessively",
"or",
"receiving",
"patenteral",
"fluids.",
"Warning",
"signs,",
"trrespective",
"of",
"cause,",
"are",
"dryness",
"of",
"mouth,",
"thirst,",
"weakness,",
"lethargy,",
"drowsiness,",
"restlessness,",
"musele",
"pains",
"Ot",
"cramps,",
"musculat",
"fotigue,",
"‘hyfutension.",
"oligutia,",
"techycardia,",
"and",
"gastrointestinal",
"distutbances",
"suth",
"as",
"nausea",
"and",
"wmitir:‘g.",
"Hypokalemia",
"may",
"develop,",
"especially",
"with",
"brisk",
"diuresis,",
"in",
"severe",
"circhosis,",
"with",
"con.",
"comitant",
"corticosterold",
"or",
"ACTH",
"therapy,",
"or",
"with",
"inadequate",
"otal",
"electrclyte",
"intake,",
"Hygokalemia",
"can",
"gensitize",
"o",
"exgggerate",
"tesponse",
"of",
"heart",
"to",
"toxic",
"effects",
"of",
"digitalis",
"(e.g.,",
"increased",
"ventrict.",
"[ar",
"teritability).",
"Hypokalemis",
"may",
"be",
"avoided",
"or",
"treated",
"by",
"use",
"of",
"potassium",
"supplements,",
"such",
"s",
"foods",
"with",
"&",
"high",
"potassium",
"content,",
"Any",
"Q00D",
"&@",
"<",
"wgn",
"chiotide",
"deficit",
"is",
"generally",
"mild",
"and",
"usually",
"does",
"not",
"tequire",
"specilic",
"treatment",
"except",
"undot",
"exteaordinary",
"circumstances",
"(as",
"in",
"liver",
"disease",
"or",
"tenal",
"disease).",
"Dilutional",
"natremia",
"may",
"otcur",
"in",
"edematous",
"patients",
"In",
"kot",
"weather;",
"appropriate",
"therapy",
"Is",
"water",
"restiiction,",
"rather",
"than",
"administeation",
"of",
"salt",
"except",
"in",
"tare",
"in",
"stanges",
"when",
"the",
"hyponatremia",
"(s",
"life",
"threaten-",
"ing.",
"In",
"actual",
"salt",
"depletion,",
"appropriste",
"teplace-",
"ment",
"is",
"the",
"therepy",
"of",
"cholce.",
"Hyperuricemia",
"may",
"occur",
"or",
"frank",
"gout",
"may",
"be",
"precipitated",
"in",
"certaln",
"patients,",
"lnsulin",
"require.",
"ments",
"in",
"diabatie",
"patients",
"be",
"intieased,",
"de-",
"created,",
"o",
"unchanged;",
"latenf",
"disdetes",
"metlitus",
"may",
"become",
"menifest.",
"Thistides",
"msy",
"increass",
"tesponsiveness",
"to",
"tudocutaring.",
"Antihypertensive",
"effects",
"of",
"the",
"em%may",
"bt",
"enhented",
"in",
"post",
"e",
"e",
"s",
"responsiveness",
"to",
"norepine;",
"mi",
"tl?us",
"not",
"wflmer‘lt",
"h?",
"L",
"fl",
"of",
"the",
"pressor",
"agen",
"apetiic",
"v,",
"‘x",
"grossive",
"renal",
"impairment",
"batomat",
"fllfifilg",
"o",
"sider",
"withholding",
"or",
"discontinuing",
"diuretic",
"thar-.",
"m.",
"Thiegides",
"may",
"decrease",
"serum",
"PBI",
"hor*",
"£",
"ttinatd",
"disboshonsa*"
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"the",
"court",
"to",
"order",
"tobacco",
"manufacturers",
"to",
"make",
"medical",
"monitoring",
"available",
"for",
"smokers,",
"fund",
"a",
"foundation",
"that",
"would",
"establish",
"anti-smoking",
"education,",
"and",
"stop",
"selling",
"cigarettes",
"to",
"minors.",
"Related",
"Story:",
"Philadelphia",
"inquirer",
"(08/09)",
"P.",
"B1",
"New",
"York—This",
"is",
"yet",
"another",
"effort",
"by",
"entrepreneurial",
"plaintiffs’",
"lawyers",
"to",
"take",
"unmeritorious",
"individual",
"cases",
"and",
"turn",
"them",
"into",
"unmanageable",
"class",
"actions.",
"As",
"the",
"Fifth",
"Circuit",
"Court",
"held",
"in",
"decertifying",
"the",
"national",
"class",
"action",
"in",
"the",
"Castano",
"case,",
"such",
"mega-cases",
"would",
"require",
"millions",
"of",
"individual",
"trials",
"before",
"they",
"could",
"be",
"finally",
"resolved.",
"Such",
"an",
"outcome",
"would",
"be",
"a",
"nightmare",
"for",
"Pennsylvania",
"courts,",
"its",
"judges,",
"and",
"citizens",
"who",
"pay",
"taxes",
"to",
"support",
"the",
"court",
"system.",
"Cases",
"brought",
"by",
"smokers",
"against",
"the",
"cigarette",
"companies",
"inevitably",
"turn",
"on",
"highly",
"individual",
"and",
"personalized",
"issues,",
"said",
"Charles",
"R.",
"Wall,",
"senior",
"vice",
"TLLLSEEI0G",
"president",
"and",
"deputy",
"general",
"counsel",
"for",
"Philip",
"Morris.",
"By",
"their",
"very",
"nature,",
"these",
"cases",
"are",
"not",
"capable",
"of",
"..",
"\"Castano",
"Lawyers\"",
"Filing",
"Of",
"Philadelphia",
"Class",
"Action",
"Is",
"Misuse",
"Of",
"Courts,",
"Says",
"Philip",
"Morris",
"U.S.A.\"Philip",
"Morris",
"Release",
"{08/08/96)",
"[full",
"text]",
"Page",
"1",
"g"
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"NO.",
"198186219070",
"P.18",
"GENERAL",
"ASSEMBLY",
"OF",
"NORTH",
"CAROLINA",
"SESSION",
"1999",
"(2}",
"Compensate",
"tobacco",
"_producers",
"d._allotment",
"holders",
"for",
"economic",
"loss",
"resulting",
"from",
"lost",
"quota",
"value",
"and",
"compensate",
"lobacco",
"producers",
"for",
"the",
"decline",
"in",
"value",
"of",
"fobacco-related",
"ersonal",
"property",
"assets",
"and",
"declining",
"marker",
"conditions",
"resultin",
"om",
"th",
"aster",
"Settlement",
"Agreement",
"<",
"nly_tobacco",
"producers.",
"tol",
"o",
"_allotraent",
"holders,",
"and",
"persons",
"engaged",
"in",
"tobacco-related",
"inesses",
"are",
"eligible",
"to",
"applv",
"for",
"and",
"receive",
"assi",
"ce",
"pursuant",
"to",
"ubsection",
"of",
"this",
"section.",
"An",
"licant",
"ma",
"a_natural",
"person,",
"partmershi",
"limited",
"liability",
"company.",
"or",
"¢",
"ration,",
"Direct",
"payments",
"made",
"to",
"tobacco",
"producers",
"and",
"tobacco",
"allotment",
"holders",
"shall",
"be",
"based",
"on",
"losses",
"resulting",
"in",
"199",
"and",
"thereafter.",
"Lost",
"quota",
"value",
"shall",
"be",
"a",
"primarv",
"determinative",
"factor",
"in",
"calculasi",
"the",
"amount",
"of",
"compensable",
"economic",
"loss",
"for",
"tobaceo",
"farmers",
"and",
"allotinent",
"holders.",
"{d)",
"e",
"ces",
"5|",
"¢",
"priority",
"of",
"awards",
"among",
"the",
"d)",
"The",
"Board",
"of",
"Trust",
"hall",
"determine",
"th,",
"categories",
"in",
"subsection",
"of",
"this",
"section",
"and",
"within",
"each",
"of",
"those",
"car",
"ies.",
"'",
"e)",
"Fipancial",
"assistance",
"awards",
"shall",
"be",
"for",
"n",
"ore",
"than",
"one",
"vear",
"at",
"2",
"time.",
"An",
"award",
"_may",
"be",
"renewed",
"annually,",
"withonr",
"limitarion,",
"The",
"Board",
"of",
"Trustees",
"may",
"reguire",
"applicants",
"1o",
"provide",
"copi",
"docyments",
"necessary",
"to",
"determine",
"compensable",
"economic",
"loss.",
"In",
"no",
"event",
"shall",
"the",
"amount",
"paid",
"&",
"tobacco",
"producer",
"or",
"allotment",
"holder",
"ursuant",
"to",
"this",
"Article,",
"when",
"combined",
"with",
"the",
"ount",
"received",
"through",
"ational",
"Tobaceo",
"Grower",
"Setdement",
"Trust,",
"exceed",
"the",
"compensable",
"economic",
"los",
"of",
"the",
"producer",
"oy",
"allotment",
"holder.",
"h",
"e",
"Board",
"of",
"Trystees",
"may",
"consider",
"the",
"criteria",
"nsed",
"for",
"Nationa",
"ohacco",
"Grower",
"Settlement",
"Trust",
"pavments",
"and",
"mav",
"correspond",
"with",
"the",
"Nation",
"Tobacco",
"rower",
"Se",
"ent_Tyust",
"certification",
"enti",
"o",
"ensure,",
"that",
"tobaeco",
"ers",
"and",
"allotment",
"holders",
"are",
"treated",
"fairly",
"“8§",
"143-721.",
"Benefits",
"and",
"administration",
"of",
"Fund",
"for",
"gualified",
"agricultnral",
"pro",
"Non-bond",
"settlement",
"funds",
"and",
"d_funds",
"held",
"in",
"the",
"Fund",
"mav",
"be",
"expended",
"on",
"qualified",
"agricuitural",
"pro",
"s",
"provided",
"in",
"this",
"secti",
"b)",
"Non-haon",
"ttlem",
"fands",
"and.",
"subject",
"&",
"e_provisions",
"of",
"resqlution_or",
"trust",
"agreement",
"anthorizing",
"and",
"securing",
"bonds",
"issued",
"the",
"State",
"pur",
"to",
"th",
"rovisions",
"of",
"icle",
"ter",
"142",
"of",
"the",
"Genera]",
"Statutes",
"bond",
"ay",
"be",
"nded",
"to",
"fon",
"e",
"costs",
"of",
"gualifi",
"rienttural",
"program",
"implementin.",
"alified",
"agricultural",
"pr",
"ms,",
"the",
"mission",
"shall",
"endeavor",
"to",
"identify",
"those",
"ar",
"the",
"tobacco-related",
"segment",
"of",
"the",
"State’s",
"ee",
"in",
"need",
"of",
"agsistanc",
"be",
"rovided",
"by",
"the",
"Fnnd",
"in",
"order",
"to",
"assure",
"the",
"continued",
"vitali",
"solvency",
"of",
"those",
"areas.",
"The",
"Commission",
"shall",
"endeavor",
"to_select",
"for",
"funding",
"qualified",
"agricnitural",
"programs",
"thar",
"will",
"have",
"the",
"greatest",
"favorable",
"impact_on",
"the",
"long-term",
"heajth",
"of",
"the",
"L",
"co~related",
"economy",
"of",
"the",
"State",
"House",
"DRH5061",
"'",
"Page",
"17",
"G¢69¥098"
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511375335+-5391-17.layout.json | [
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"17",
"Z6€s",
"LETTS"
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509638162+-8218-48.layout.json | [
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"a",
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"ppm",
"for",
"90",
"days",
"2500",
"ppm",
"for",
"90",
"days",
":",
"“)",
"1000",
"ppm",
"for",
"2",
"yr",
"5000",
"ppm",
"for",
"2.yr",
"’",
"(6",
".",
"7",
"Not",
"established",
"1000",
"ppm",
"for",
"2",
"yr",
".",
":",
")",
")",
"W",
"Oral",
"135",
"mg/kg/day",
"for",
"405",
"thg/kg/day",
"for",
"135",
"mg/kg/day",
"for",
"e",
"7",
"days",
"7",
"days",
"7",
"days",
"(&)",
"e",
":",
"10-20",
"mg/kg/day",
"for",
"7",
"days",
"8)",
"7-HC",
"=",
"7-Hydroxycoumarin",
"*Biochemica!",
"histochemical",
"or",
"ultrastructural.",
"tReferences:",
"(1)",
"Gangolli",
"et",
"al",
"(1974);",
"(2)",
"Evans",
"ef",
"(5)",
"Endell",
"&",
"Seidcl",
"(1978).",
"(6)",
"Biir",
"&",
"Griepentrog",
"(19",
"(1973);",
"(10)",
"Paiyra",
"et",
"al.",
"(1965).",
"{Bodyweight.",
"IFour",
"doses.",
"marin,",
"to",
"rats",
"brought",
"about",
"a",
"reduction",
"in",
"liver-",
"microsomal",
"glucose-6-phosphatase",
"activity",
"and",
"an",
"in-",
"crease",
"in",
"cytoplasmic",
"glucose-6-phosphate",
"dehydro-",
"genasc",
"activity.",
"In",
"general,",
"glucose-6-phosphatase",
"proved",
"1o",
"be",
"the",
"more",
"sensitive",
"to",
"the",
"action",
"of",
"the",
"hepatotoxic",
"agents",
"{Feucr,",
"Golberg",
"&",
"Le",
"Pelley,",
"1965a).",
"These",
"hepatic",
"enzyme",
"changes",
"became",
"appar-",
"ent",
"within",
"2-3",
"days",
"of",
"administration",
"of",
"daily",
"oral",
"doses",
"of",
"100-200",
"mg/kg",
"or",
"within",
"7",
"days",
"of",
"daily",
"oral",
"doses",
"of",
"10-20",
"mg/kg",
"to",
"rats",
"(Feuer,",
"Golberg",
"&",
"Le",
"Pelley,",
"1965b).",
"The",
"latter",
"dose",
"is",
"about",
"five",
"times",
"lower",
"than",
"the",
"dose",
"required.to",
"produce",
"histological",
"damage",
"to",
"the",
"liver",
"in",
"rats",
"(IJazleton",
"et",
"al.",
"1956;",
"see",
"also",
"Table",
"6).",
"When",
"rat-liver",
"microsomes",
"werc",
"treated",
"in",
"vitro",
"with",
"coumarin",
"or",
"various",
"hydroxycoumarins,",
"glucose-6-phosphatase",
"was",
"unaffected,",
"but",
"enzyme",
"inhibition",
"did",
"occur",
"following",
"treatment",
"with",
"o-hy-",
"_droxyphenylaceticacid",
"and",
"o-hydroxyphenylactic",
"acid,",
"especially",
"the",
"former",
"(Feuer",
"et",
"al.",
"1966).",
"Glucose-6-",
"phosphatase",
"inhibition",
"by",
"o-hydroxyphenylacetic",
"acid",
"was",
"also",
"demonstrated",
"in",
"liver",
"microsomes",
"from",
"rab-",
"bits,",
"monkeys",
"and",
"man.",
"Oral",
"and",
"parenteral",
"adminis-",
".",
"tration",
"of",
"o-hydroxyphenylacetic",
"acid",
"(50-100",
"mg/kg/",
"day",
"for",
"7",
"days)",
"also",
"decreased",
"glucose-6-phosphatase",
"activity",
"and",
"it",
"scems",
"probable",
"that",
"the",
"cflect",
"of",
"cou-",
"marin",
"in",
"reducing",
"glucose-6-phosphatase",
"is",
"mainly",
"due",
"‘to",
"its",
"metabolite,",
"o-hydroxyphenylacetic",
"acid",
"{Feuer",
"et",
"al.",
"1966).",
"In",
"order",
"to",
"throw",
"more",
"light",
"on",
"the",
"significance",
"of",
"glucose-6-phosphatase",
"depression",
"in",
"terms",
"of",
"hepa-",
"tocellular",
"damage,",
"Grasso,",
"Wright,",
"Gangolli",
"&",
"Hendy",
"(1974)",
"followed",
"the",
"biochemical,",
"histological",
"and",
"ultrastructural",
"changes",
"taking",
"place",
"in",
"the",
"liver",
"of",
"coumarin-treated",
"rats.",
"It",
"was",
"found",
"that",
"scven",
"daily",
"oral",
"doses",
"of",
"15",
"or",
"45",
"mg/kg",
"had",
"no",
"cflect",
"on",
"Tiver",
"weight,",
"liver",
"histology",
"or",
"any",
"of",
"the",
"biochemical,",
"histochemical",
"or",
"ultrastructural",
"criteria",
"examined.",
"By",
"al.",
"(1979);",
"(3)",
"Hagan",
"et",
"al.",
"(1967);",
"(4)",
"Hazleton",
"et",
"a{.",
"(1956):",
"67):",
"(7)",
"Grasso",
"et",
"al.",
"(1974);",
"(8)",
"Feuer",
"er",
"dl.",
"(1965b):",
"(9)",
"Gricpentrog",
"increasing",
"the",
"dose",
"to",
"135",
"mg/kg,",
"liver",
"enlaigement",
"occurred,",
"accompanied",
"by",
"biochemical",
"changes",
"{reductions",
"in",
"cytochrome",
"P-450",
"and",
"amidopyrine-",
"demethylase",
"activity),",
"histochemical",
"-changes",
"(centri-",
"lobular",
"loss",
"of",
"glucose-6-phosphatasc",
"and",
"aniline",
"hy-",
"droaylase,",
"and",
"changes",
"in",
"lysosomal",
"acid",
"phospha-",
"tase)",
"and",
"ultrastructural",
"changes",
"(gross",
"hypcrtrophy",
"and",
"dilatation",
"of",
"the",
"rough",
"endoplasmic",
"reticulum,",
"an",
"increasc",
"in",
"the",
"number",
"and",
"size",
"of",
"lysosomes",
"ant",
"an",
"increased",
"iincidence",
"of",
"autophagic",
"vacuoles).",
"When",
"the-dose",
"was",
"increased",
"still",
"further,",
"to",
"405",
"mg/kg.",
"these",
"biochemical,",
"histochemical",
"and",
"ultrastructural",
"changes",
"were",
"accompanicd",
"for",
"the",
"first",
"time",
"by",
"ihisto-",
"logical",
"liver",
"damage.",
"The",
"hypertrophy",
"of",
"rough",
"endo-",
"plasmic",
"reticulum",
"indicated",
"an",
"enhanceinent",
"of",
"pro-",
"tein",
"synthesis",
"in",
"agreement",
"with",
"the",
"biochemical",
"evi-",
"dence",
"of",
"increased",
"protein",
"synthesis",
"in",
"the",
"liver",
"of",
"rats",
"given",
"S0-450",
"mg",
"coumarinfkg/day",
"for",
"3-7",
"days",
"(Nievel,",
"1959).",
"From",
"their",
"study",
"of",
"the",
"cytopathologi-",
"cal",
"changes",
"in",
"the",
"enlarged",
"but",
"histologically",
"normal",
"liver",
"of",
"coumarin-treated",
"rats,",
"Grasso",
"et",
"al.",
"(1974)",
"concluded",
"that",
"doses",
"producing",
"liver",
"enlargement",
"also",
"produce",
"histochemical",
"and",
"electron-microscopic",
"indications",
"of",
"liver",
"damage.",
"while",
"doses",
"insufficient",
"to",
"cause",
"liver",
"enlargement",
"are",
"unable",
"to",
"elicit",
"such",
"changes.",
"Discussion",
".",
"The",
"current",
"review",
"has",
"highlighted",
"three",
"crucial",
"issues",
"worthy",
"of",
"discussion:",
"(1)",
"Classification",
"of",
"coumarin",
"by",
"OSHA",
"as",
"a",
"Cate-",
"gory",
"I",
"carcinogen",
"on",
"the",
"basis",
"of",
"the",
"controversial",
"finding",
"of",
"‘bile-duct",
"carcinomas’",
"in",
"rats",
"(Bir",
"&",
"Griepentrog,",
"1967;",
"Griepentrog.",
"1973)",
"and",
"of",
"the",
"erroncous",
"citing",
"in",
"the",
"NIOSH",
"Registry",
"(National",
"Institute",
"for",
"Occupational",
"Safcty",
"and",
"Health,",
"1977)",
"of",
"a",
"pesitive",
"result",
"for",
"a",
"study",
"on",
"mouse-skin",
"tumour-"
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"/3",
"ég",
"R",
"2\\",
"il",
".",
"Ji",
"Application",
"for",
"Research]",
"Iyt",
"}",
"\\",
"o",
"Do",
"e",
"{Use",
"extro",
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"o3",
"ne",
"el",
"s",
"8Ty",
"J",
"Stanley",
"Yachnin,",
"M.D.",
"The",
"University",
"of",
"Chicego",
"Hedical",
"Center",
"Professor",
"of",
"kedicine",
"950",
"East",
"59th",
"Street,",
"Box",
"420",
".",
"Chief,",
"Section",
"of",
"Hematology/Oncology",
"Chicago,",
"IL",
"60537",
"t)",
"4.",
"Shorttitle",
"of",
"siudy:",
"Models",
"for",
"the",
"Pathogenesis",
"of",
"Atherosclerosis:",
"a)",
"Bielogical",
"Effects",
"of",
"Oxygenated",
"Sterol",
"Compounds,",
"b)",
"Mevalonic",
"Acid",
"and",
"Cholesterol",
"_Biosynthesis",
"and",
"the",
"Regulation",
"of",
"Cell",
"Growth.",
"7.",
"Bricf",
"description",
"of",
"tpecific",
"research",
"aims;",
"The",
"fo1lowin§",
"investigations",
"are",
"currently",
"undervay",
"and",
"would",
"be",
"pursued",
"during",
"the",
"grant",
"period",
"envisioned:",
".",
"°",
"1.",
"HMeasurement",
"of",
"the",
"insertion",
"of",
"oxygenated",
"sterol",
"compoufiE?‘TUIfT-TFEo",
".",
"human",
"red",
"cell",
"and",
"Tymphocyte",
"membranes.",
"2.",
"The",
"relatiqnshig",
"of",
"such",
"insertion",
"tg",
"functional",
"and",
"morphological",
"alterations",
"such",
"as",
"echinocyte",
"formation",
"and",
"decreased",
"osmotic",
"fregility",
"in",
"red",
"cells,",
"and",
"inhibition",
"of",
"E-rosette",
"formation",
"and",
"Tymphocyte",
"capping",
"in",
"human",
"lymphocytes,",
".",
".",
"3..",
"A",
"study",
"of",
"the",
"binding",
"of",
"0SC",
"by",
"various",
"lipoprotein",
"fractions",
"of",
"human",
".serum.",
"4.",
"A",
"study",
"of",
"the",
"effects",
"of",
"human",
"serum",
"lipoproteins",
"on",
"the",
"insertion",
"of",
"0SC",
"into",
"red",
"cell",
"and",
"Iymphocyte",
"membranes.",
"'",
"5.",
"A",
"study",
"of",
"the",
"effects",
"of",
"0SC",
"and",
"ML-236B",
"(Compactin)",
"on",
"human",
"1ymphocyte",
"proliferation",
"in",
"vitro.",
"6.",
"A",
"study",
"of",
"the",
"effects",
"of",
"0SC",
"and",
"ML-236B",
"on",
"the",
"syrnthesis",
"of",
"sterol",
"and",
"nonsterol",
"derived",
"products",
"of",
"mevalonic",
"acid",
"in",
"human",
"lymphocytes.",
"7.",
"A",
"study",
"of",
"the",
"initiation",
"of",
"cell",
"growth",
"in",
"human",
"Iymphocytes",
"by",
")",
"_)",
"mevelonic",
"acid.",
"Is",
"growth",
"inftiated",
"by",
"mevalonate-derived",
"stergl",
"biosynthesis",
"or",
"by",
"the",
"formation",
"of",
"a",
"nonsterol",
"biosynthetic",
"preduct",
"of",
"mavalonic",
"acid?",
"8.",
"A",
"study",
"of",
"the",
"inhibition",
"of",
"the",
"formation",
"of",
"CFU-C",
"in",
"vitro",
"Srom",
"0",
"&",
"L",
"human",
"bone",
"marroy",
"mononuciear",
"cells",
"by",
"0SC",
"and",
"ML-2388.",
"e",
"//3@’,3",
"2/-",
".",
"7.",
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"dcta",
"have",
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"hypothesis:",
"e",
"have",
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"regdd",
"w0",
"their",
"Capacity",
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"syntnesize",
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"other",
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"incorporation",
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"acid",
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"to",
"enhance",
"the",
"cellular",
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"subseguently",
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"mevalonic",
"acid",
"has",
"a",
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"results",
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"lymphocyte",
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"(A)",
"it",
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"the",
"nelper",
"which",
"thus",
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"potential",
"to",
"enter",
"lymphocytes",
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"mevalonic",
"acid",
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"available",
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"subply",
"sterg]",
"(and",
"possibly",
"nensieral)",
"necessary",
"for",
"the",
"permissive",
"support",
"of",
"cell",
"proliferation.",
"Since",
"preliminary",
"experiments",
"have",
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"that",
"cultured",
"supernatants",
"of",
"\"bottom”",
"fraction",
"cells",
"incu-",
"bated",
"with",
"or",
"without",
"mevalonic",
"acid",
"fail",
"to",
"substitute",
"for",
"the",
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"themselves,",
"the",
"possibility",
"that",
"help",
"is",
"provided",
"by",
"a",
"secreted",
"mediator",
"is",
"made",
"less",
"Tikely.",
"Kavertheless",
"a",
"short",
"range",
"potentiating",
"factor",
"of",
"relatively",
"brief",
"biological",
"half-",
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"close",
"apposition",
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"populations",
"in",
"cultyre",
"may",
"be",
"invelvad,",
"or",
"the",
"effect",
"may",
"involve",
"some",
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"responding",
"lympho-",
"only",
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"by",
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"contact",
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"the",
"helper",
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"Our",
"recent",
"observations",
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"peripheral",
"blood",
"lymphocytes",
"from",
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"patients",
"with",
"chronic",
"Teukemia",
"enter",
"call",
"cycle",
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"synthesize",
"DNA",
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"mevalonic",
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"absence",
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"a",
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"emphasize",
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"nzutrophils",
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"bettom",
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"always",
"required",
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"selected",
"human",
"Tymphocyte",
"populations",
"respond",
"to",
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"acid",
"in",
"this",
"manner.",
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"v",
"TOr",
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"effects",
"gf",
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"fraction",
"cells",
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"DNA",
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"Cxte",
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"intracellular",
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"responses",
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71426626-5.layout.json | [
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"life",
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"total",
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"€xpectancy",
"according",
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"significant",
"ar",
"age",
"75.",
"€xpectancy",
"and",
"reduced",
"sample",
"size,",
"the",
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"is",
"no",
"longer",
"statistically",
"significant",
"(data",
"not",
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"better",
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"results",
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"in",
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"2,",
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"as",
"a",
"general",
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"expectancy.",
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"defined",
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"a",
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"average",
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ti17450935_0939-2.layout.json | [
"The",
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"November",
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"]",
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"a",
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"[Rev.",
"Stat.",
"Section",
"18-13-121.",
"House",
"Bill",
"1088,",
"1991;",
"Laws",
"page",
"676,",
"1987",
"]",
"LICENSE",
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"[Rev.",
"Stat.",
"Section",
"39-28-102",
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"39-28-101(4).]",
"VENDING",
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"RESTRICTIONS:",
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"Stat.",
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"18-13-121.",
"House",
"Bill",
"1088,",
"1991;",
"Laws",
"page",
"676,",
"1987.)",
"OTHER:",
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"TI745-0937"
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