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are reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures. | Participant Requirements | Study Participation Requirements |
Section 3.1 Within thirty (30) days after Shipper’s receipt of Carrier’s delivery receipt, Shipper shall pay Carrier the rates and charges applicable to the shipment of cargo. In exchange for Shipper’s guarantee of prompt payment, (i) agrees not to contact Shipper’s customers, consignors, consignees or any party other than Shipper
concerning payment for transportation services; and, (ii) agrees to indemnify, defend, and hold Shipper, its customers, consignors, and consignees harmless from any claim or demand made by any subcontractor of Carrier or other party for payment for transportation services related to a shipment of cargo tendered under this Agreement. | Payment Terms | Payment Terms |
Change in Services. If Client desires changes to the SOW, Client shall submit to Company a written request in accordance with the change order process defined in the applicable SOW. The parties may execute additional Statements of Work describing Services, which will become part of this Agreement upon execution by Company and the Client. If additional SOW are executed, then Client shall pay Company for all services performed prior to the additional SOW before Company begins work on the new SOW. | Change Order Process | Change Order Process |
MOTOR RED II
Version Number 1.3
Page 3 of 14
Revision Date 12/10/2015
Print Date 12/11/2015 | Document Metadata | Motor Red Coverage Details |
Customer Service Fees. This component of the Fees shall be payment for the customer services performed by CRD pursuant to the Operating Guidelines, which fees (the “Customer Support Fees”), with respect to each Product or group of Products identified in the same Product-specific exhibit to this agreement, shall be in the amount specified in such exhibit. | Customer Service Fees | Customer Service Fees |
Crime Additional Coverages DX T4 15 | Crime Coverage | Crime Coverage |
Building Personal Property - CONTENTS
Valuation
REPLACEMENT COST
Property Deductible
$10,000
Wind/Hail Ded. ($ or %)
1
Theft Coverage
YES
Coinsurance
90
Earthquake Coverage
NO
Agreed Value
YES
Causes of Loss - Special Form
Spoilage Coverage Endorsement
$419.00 | Insurance Coverage Details | Building Personal Property Coverage |
On behalf of INSA LLC and The InsuranceA Indemnity Company and its Affiliates*, we appreciate the opportunity to provide NO1 REAL ESTATE INC. with the ollowing policy proposal.
InsuranceA Risk Control: Our Expertise is Your Advantage
InsuranceA Risk Control is an innovative provider of cost-effective risk management services and products. As one of the largest Risk Control departments in the industry, our scale allows the right resource at the right time to meet customer needs. For over 110 years, our loss prevention professionals have assisted agents, brokers and customers across the country and around the world.
https://www.InsuranceA.com/risk-control
Claim Services:
InsuranceA has over 11,000 highly trained Claim professionals located across the
U.S. Our local field representatives are supported by teams of dedicated customer service, catastrophe response, legal, medical, investigative, engineering, and large loss experts. Technology claims can be complex and expensive. We’ll help you manage claims to control your total risk-related costs.
https://www.InsuranceA.com/claims | InsuranceA Risk Control Services | Claims Services |
Constitutional - NAD, has been generally feeling well the last couple of weeks Eyes - no changes in vision, double vision, blurry vision, wears glasses ENT - No congestion, changes in hearing, does not wear hearing aids Skin/Breast - no rashes Cardiovascular - No SOB, chest pain, heart palpitations Pulmonary - hard to get a breath in but not short of breath, no cough Endocrine - No changes in appetite Gastro Intestinal - No n/v/d or constipation. Has not eaten because can't swallow solid
foods.
Genito Urinary - No increased frequency or pain on urination. Some urge incontinence
with history of prolapse. Musculo Skeletal - no changes in strengths, no joint tenderness or swelling Neurologic - No changes in memory Psychology - No changes in mood Heme/Lymph - Denies easy bruising | Constitutional and System Review | Treatment Plan |
As respects Business Income Coverage a 72 hour deductible applies at all premises locations. | Business Income Deductible | Business Income Coverage |
Utility Services — Direct Damage
Overhead transmission lines excluded; coverage can be purchased | Utility Services - Exclusions | Utilty Services |
3. Introduction
3.1. Study Rationale
A prandial insulin with faster-on and/or faster-off characteristics might reduce glycemic excursions and the incidence of postprandial hypoglycemia compared to currently available fast-acting insulin analogs. LY900014 is an ultra-rapid-acting insulin lispro formulation that has shown an increased early absorption compared to commercially available insulin lispro (Humalog®; Eli Lilly). LY900014 aims to closely mimic the physiological prandial insulin secretion pattern, which may more effectively control postprandial glucose excursions and allow increased flexibility of the time of dosing relative to a meal.
This study aims to compare PK and PD profiles as well as the improved action of insulin lispro from LY900014 on the control of postprandial blood glucose in comparison to Humalog in patients with T1DM. The improved action of insulin lispro will be assessed by using standardized mixed-meal tolerance test (MMTTs). Furthermore, this study will explore the postprandial glucose profiles with LY900014 and Humalog injected at two different meal-to- dose time intervals either immediately before or 20 minutes following the start of the test meal, to optimize future use of this investigational medicinal product (IMP).
3.2. Background
The insulin analog insulin lispro (Humalog) has been shown to be absorbed more quickly than regular human insulin (Humalog package insert, 2015). In healthy volunteers given subcutaneous (SC) doses of insulin lispro ranging from 0.1 to 0.4 units (U)/kg, peak serum levels were seen 30 to 90 minutes after dosing (Humalog package insert, 2015). However, the general consensus is that rapid-acting insulin is still not rapid enough to match carbohydrate absorption profiles, which limits efficacy and dosing flexibility. An ultra-rapid-acting prandial insulin would shift the PK/GD of insulin analogs so that they have an even faster onset to better match carbohydrate absorption and also allow greater flexibility in the time of dosing relative to meals.
LY900014 represents a new formulation that contains insulin lispro, treprostinil, citrate and other excipients. This formulation involves the novel use of a microdose of treprostinil ( C ) as an excipient to enhance the absorption of insulin lispro by local vasodilatation rather than as C an active pharmaceutical ingredient to elicit a systemic effect. Treprostinil is a prostacyclin analogue, administered either through inhalation ( C ), as an intravenous (IV) infusion or as a continuous SC administration for the treatment of symptomatic C pulmonary arterial hypertension (PAH) and has been approved in the US since 2002 and in Germany since 2006 (AMIS database [WWW]). Sodium citrate, an excipient that speeds insulin absorption (at least in part by enhancing vascular permeability), is also included in the formulation to further enhance the absorption of insulin lispro. Each of the other excipients (such as magnesium chloride) in the LY900014 formulation is listed in the US Food and Drug Administration
(FDA)’s Generally Recognized as Safe Food Additives database and in the FDA’s Inactive Ingredients in Approved Drugs database. Furthermore, the excipient concentration in LY900014 is within the limits identified for approved drug products in the FDA Inactive Ingredients in Approved Drugs database. To date, LY900014 has been administered to approximately 89 patients with diabetes (60 T1DM and 29 T2DM) across 3 Phase 1b studies and approximately 107 healthy volunteers across these Phase 1 studies. The total insulin lispro exposure was similar between LY900014 and Humalog; however LY900014 demonstrated a faster and earlier insulin lispro absorption compared to Humalog. Additionally, through the use of multiple daily injections of LY900014 for up to 2 weeks in patients with either T1DM or T2DM, it was found that LY900014 was well tolerated. There were no serious adverse events (SAEs) related to study treatment or discontinuations from the studies because of a drug-related adverse event (AE). Small numbers of treatment-emergent adverse events were reported, and there were no notable increases in these events in relation to any of the LY900014 formulations compared to those in relation to Humalog. There were no reported cases of severe hypoglycemia. Additionally, there was no reported incidences of local or systemic allergic reactions.
3.3. Benefit/Risk Assessment
This study will not offer any direct benefits to the patients participating in the study. The data from previous studies in healthy patients and patients with T1DM and T2DM have shown that LY900014 was well tolerated and the adverse drug reactions are in keeping with those reported for Humalog.
Potential risks associated with LY900014, derived from the known risks of insulin lispro (Humalog), are hypoglycemia, hypersensitivity reactions (localized allergy and/or systemic allergy), undesirable effects at the injection site (injection-site reactions and lipodystrophy), and peripheral edema (Humalog package insert, 2015).
Notably, across all doses in the studies that have evaluated treprostinil ( CCI ) as a local vasodilator with or without insulin lispro, there was no clinically significant increase in those AEs associated with systemic absorption of treprostinil, as described in the CCI package insert (2014). The exposures of treprostinil in LY900014 in this study are expected to be undetectable compared to those observed in the dose ranges previously explored with SC bolus administration of treprostinil and are expected to be substantially lower than those observed in the treatment of PAH. No known potential risks are associated with the use of small amounts of treprostinil in the LY900014 formulation.
In preclinical safety pharmacology and toxicity studies, or clinical pharmacology studies involving LY900014 or treprostinil alone, other than known risks associated with Humalog and CCI , no additional risks were identified. Additionally, local and systemic toxicity profiles of Humalog and CCI do not suggest the potential for additive or synergistic toxicity
The study includes inpatient procedures during which participants will be continuously monitored. Patients will be without food intake from the start of the MMTT to completion of blood collection (approximately 420 minutes) unless required to treat hypoglycemia, (see Section
9.5.6.2 for definition of hypoglycemia and Section 9.5.8 for treatment guidelines). If a patient experiences elevated blood glucose following food intake for more than 1 hour, insulin glulisine will be administered intravenously (see Section 9.5.8 for treatment guidelines). Patients will maintain their basal insulin regimen of site-provided insulin glargine during the entire study including the MMTT days unless safety issues arise; in this case, the investigator will discuss a change of the basal insulin regimen with the sponsor clinical pharmacologist (CP) and implement this change, if necessary, to prevent any medical problems.
More information about the known and expected benefits, risks, serious adverse events (SAEs) and reasonably anticipated adverse events (AEs) of LY900014 are to be found in the Investigator’s Brochure (IB).
4. Objectives and Endpoints
Table ITRV.1 shows the objectives and endpoints of the study. | Study Rationale and Background | Objectives and Endpoints |
Problem List:
Dysarthria, right sided weakness, AMS, possible incontinence
CT of head with right side infarct of indeterminate age
Low K at 3.2
HTN, uncontrolled
Hyperlipidemia
DM type 2
Cocaine, marijuana, and tobacco abuse
Residual right sided weakness requiring the use of a cane
Financial situation limiting ability to attain medications, med noncompliance | Patient Diagnoses | Problem List |
The insulin analog insulin lispro (Humalog) has been shown to be absorbed more quickly than regular human insulin (Humalog package insert, 2015). In healthy volunteers given subcutaneous (SC) doses of insulin lispro ranging from 0.1 to 0.4 units (U)/kg, peak serum levels were seen 30 to 90 minutes after dosing (Humalog package insert, 2015). However, the general consensus is that rapid-acting insulin is still not rapid enough to match carbohydrate absorption profiles, which limits efficacy and dosing flexibility. An ultra-rapid-acting prandial insulin would shift the PK/GD of insulin analogs so that they have an even faster onset to better match carbohydrate absorption and also allow greater flexibility in the time of dosing relative to meals.
LY900014 represents a new formulation that contains insulin lispro, treprostinil, citrate and other excipients. This formulation involves the novel use of a microdose of treprostinil ( C ) as an excipient to enhance the absorption of insulin lispro by local vasodilatation rather than as C an active pharmaceutical ingredient to elicit a systemic effect. Treprostinil is a prostacyclin analogue, administered either through inhalation ( C ), as an intravenous (IV) infusion or as a continuous SC administration for the treatment of symptomatic C pulmonary arterial hypertension (PAH) and has been approved in the US since 2002 and in Germany since 2006 (AMIS database [WWW]). Sodium citrate, an excipient that speeds insulin absorption (at least in part by enhancing vascular permeability), is also included in the formulation to further enhance the absorption of insulin lispro. Each of the other excipients (such as magnesium chloride) in the LY900014 formulation is listed in the US Food and Drug Administration
(FDA)’s Generally Recognized as Safe Food Additives database and in the FDA’s Inactive Ingredients in Approved Drugs database. Furthermore, the excipient concentration in LY900014 is within the limits identified for approved drug products in the FDA Inactive Ingredients in Approved Drugs database. To date, LY900014 has been administered to approximately 89 patients with diabetes (60 T1DM and 29 T2DM) across 3 Phase 1b studies and approximately 107 healthy volunteers across these Phase 1 studies. The total insulin lispro exposure was similar between LY900014 and Humalog; however LY900014 demonstrated a faster and earlier insulin lispro absorption compared to Humalog. Additionally, through the use of multiple daily injections of LY900014 for up to 2 weeks in patients with either T1DM or T2DM, it was found that LY900014 was well tolerated. There were no serious adverse events (SAEs) related to study treatment or discontinuations from the studies because of a drug-related adverse event (AE). Small numbers of treatment-emergent adverse events were reported, and there were no notable increases in these events in relation to any of the LY900014 formulations compared to those in relation to Humalog. There were no reported cases of severe hypoglycemia. Additionally, there was no reported incidences of local or systemic allergic reactions. | Formulation Details | Study Objectives |
that the Renewal Term shall be upon the same terms, covenants and conditions as in this lease provided, except that (i) there shall be no further option to extend this lease beyond the Renewal Term referred to above; (ii) the Demised Premises shall be delivered in its then “as is” condition; and (iii) the Rent to be paid by Tenant during the Renewal Term shall be as follows: The Rent for the first year of the subject Renewal Term shall be equal to the greater of (A) ninety-five (95%) percent of the Fair Market Minimum Annual Rent (as hereinafter defined), but in no event higher than one hundred ten (110%) percent of the Rent payable during the Lease Year immediately preceding the first day of the Renewal Term, and (B) one hundred three (103%) percent of the Rent payable during the Lease Year immediately preceding the first day of the Renewal Term. Thereafter, the Rent for each year of the Renewal Term shall be increased by three (3%) percent of the Rent payable for the prior year of the Renewal Term. As used herein, the term “Fair Market Minimum Annual Rent” shall mean the rate then being received by landlords when entering into new leases for comparable size space in comparable buildings for a comparable term in the vicinity of the Building. | Renewal Term | Renewal Term |
Upon the execution of this Lease and thereafter not less than fifteen days prior to the expiration date of any policy delivered pursuant to this Article, Tenant shall deliver to Landlord the originals of all policies or renewal policies, as the case may be, required by this Lease, bearing notations evidencing the payment of the premiums therefor, which premiums may be paid by Tenant in installments if such payment of premiums by installments is provided for and permitted by such original or renewal policies . In lieu of any such policies, Tenant may deliver certificates of the insurer, in form and substance satisfactory to Landlord, as to the issuance and effectiveness of such policies and the amounts of coverage afforded thereby, accompanied by copies of such policies. Such insurance may be provided through a blanket policy or policies in form and substance satisfactory to Landlord. Such blanket policies shall provide specific allocation to the demised premises of the coverage afforded thereby, and shall give to Landlord no less protection than that which would be afforded by separate policies. | Insurance Policies and Certificates | Insurance Policies and Certificates |
Tenant, at Tenant's sole cost and expense, shall be responsible for the removal and disposal of all of garbage, waste, and refuse from the Premises on a daily basis. Tenant shall cause all garbage, waste and refuse to be stored within the Premises until thirty (30) minutes before closing, except that Tenant shall be permitted, to the extent permitted by law, to place garbage outside the Premises after the time specified in the immediately preceding sentence for pick up prior to 6:00 A.M. next following. Garbage shall be placed at the edge of the sidewalk in front of the Premises at the location furthest from the main entrance to the Building or such other location in front of the Building as may be specified by Landlord.
Tenant, at its sole cost and expense, agrees to use all reasonable diligence in accordance with the best prevailing methods for the prevention and extermination of vermin, rats, and mice, mold,
fungus, allergens, bacteria and all other similar conditions in the Premises. Tenant, at Tenant's expense, shall cause the Premises to be exterminated from time to time to the reasonable satisfaction of Landlord and shall employ licensed exterminating companies. Landlord shall not be responsible for any cleaning, waste removal, janitorial, or similar services for the Premises, and Tenant shall not be entitled to seek any abatement, setoff or credit from the Landlord in the event any conditions described in this Article are found to exist in the Premises. | Garbage Removal and Vermin Prevention | Garbage Removal and Vermin Prevention |
Direct loss or damage to moved property | Moved Property Coverage | Moved Property Coverage |
This SOW is an attachment to, and is incorporated by this reference into the Agreement as if fully set forth therein and made a part thereof. This SOW, together with the Agreement, represents the complete and total understanding of the parties regarding the Services to be provided by Company hereunder. | Incorporation of SOW | SOW and Agreement Integration |
Tenant shall make all rental payments in full. Payment or receipt of a rental payment of less than the amount stated in this Lease shall be deemed to be nothing more than partial payment on account. Under no circumstances shall Landlord’s acceptance of a partial payment constitute accord and satisfaction. Nor will Landlord’s acceptance of a partial payment forfeit Landlord’s right to collect the balance due on the account, together with applicable late charges and interest despite any endorsement, stipulation, or other statement on any check. | Rental Payments | Rental Payments |
Limited Coverage for Fungus, Wet Rot or | Limited Coverage | Limited Coverage for Fungus, Wet |
a corporation (which is not an accredited investor (as defined in Section 4A of the | Accredited Investor Definition | Accredited Investor Definition |
If Landlord applies or retains all or any portion of the Security, Tenant shall pay to Landlord, within five (5) days of Landlord’s demand, as additional rent the amount so applied or retained, so that the un-applied Security shall be at all times no less than an amount equal to three times the monthly fixed rent then reserved under Article 40 of this Lease. | Security Retention Payment | Security Deposit Retention |
All days other than Saturdays, Sundays, or Legal Holidays. | Business Days | Sale and Transfer Tax Exemption |
Neurological – Alert and oriented x 3, CN 2-12 grossly intact. | Neurological Assessment | Neurological Exam |
If at any time Tenant shall neglect or fail to provide or maintain insurance or to deliver insurance policies in accordance with this Article, Landlord may effect such insurance as agent for Tenant, by taking out policies in a company satisfactory to Landlord, and the amount of the premiums paid for such | Tenant Insurance Compliance | Insurance Requirements |
Location:
Jagel, Germany
Accident Number:
DEN08WA037
Date & Time:
11/28/2007, 1800 UTC
Registration:
N141CD
Aircraft:
Cirrus Design Corp. SR-20
Aircraft Damage:
Substantial
Defining Event:
Injuries:
1 Fatal
Flight Conducted Under:
Part 91: General Aviation - Ferry
On November 28,, 2007, at 1800 UTC, a Cirrus Design Corporation SR-20, N141CD, serial number 1032, while on approach for landing at Jaleg, Schleswig-Holsteinschen, Germany, struck power lines and subsequently impacted terrain. The airplane was destroyed and the private pilot, the sole person on board the airplane, was fatally injured. Instrument meteorological conditions prevailed at the time of the accident. The cross-country ferry flight originated in the Netherlands and was en route to Sylt, Germany.
This investigation is under the jurisdiction and control of the German government. Any further information may be obtained from:
German Federal Bureau of Aircraft Accidents Investigation Bundesstelle fur Flugenfallensuchung (BFU)
Herman-Blenk Strasse 16 38108 Braunschweig
Germany
This report is for informational purposes only and contains only information released by, or obtained from, the BFU of Germany.
Page 1 of 3
Pilot Information
Certificate:
Age:
Airplane Rating(s):
Seat Occupied:
Other Aircraft Rating(s):
Restraint Used:
Instrument Rating(s):
Second Pilot Present:
Instructor Rating(s):
Toxicology Performed:
Medical Certification:
Last FAA Medical Exam:
Occupational Pilot:
Last Flight Review or Equivalent:
Flight Time:
Aircraft and Owner/Operator Information
Aircraft Make:
Cirrus Design Corp.
Registration:
N141CD
Model/Series:
SR-20
Aircraft Category:
Airplane
Year of Manufacture:
Amateur Built:
No
Airworthiness Certificate:
Serial Number:
Landing Gear Type:
Seats:
Date/Type of Last Inspection:
Certified Max Gross Wt.:
Time Since Last Inspection:
Engines:
Airframe Total Time:
Engine Manufacturer:
ELT:
Engine Model/Series:
Registered Owner:
Rated Power:
Operator:
Operating Certificate(s) Held:
None
Meteorological Information and Flight Plan
Conditions at Accident Site:
Instrument Conditions
Condition of Light:
Observation Facility, Elevation:
Distance from Accident Site:
Observation Time:
Direction from Accident Site:
Lowest Cloud Condition:
Visibility
Lowest Ceiling:
Visibility (RVR):
Wind Speed/Gusts:
/
Turbulence Type Forecast/Actual:
/
Wind Direction:
Turbulence Severity Forecast/Actual:
/
Altimeter Setting:
Temperature/Dew Point:
Precipitation and Obscuration:
Departure Point:
Type of Flight Plan Filed:
Unknown
Destination:
Jaleg, UN
Type of Clearance:
Departure Time:
Type of Airspace:
Airport Information
Airport:
Runway Surface Type:
Airport Elevation:
Runway Surface Condition:
Runway Used:
IFR Approach:
Runway Length/Width:
VFR Approach/Landing:
Wreckage and Impact Information
Crew Injuries:
1 Fatal
Aircraft Damage:
Substantial
Passenger Injuries:
N/A
Aircraft Fire:
Ground Injuries:
N/A
Aircraft Explosion:
Total Injuries:
1 Fatal
Latitude, Longitude:
Administrative Information
Investigator In Charge (IIC):
David C Bowling
Additional Participating Persons:
Karsten Severin; German BFU
Investigation Docket:
NTSB accident and incident dockets serve as permanent archival information for the NTSB’s investigations. Dockets released prior to June 1, 2009 are publicly available from the NTSB’s Record Management Division at pubinq@ntsb.gov, or at 800-877-6799. Dockets released after this date are available at http://dms.ntsb.gov/pubdms/. | Accident Report | Accident Details |
At Premises Outside of the Coverage Territory | Outside Coverage Territory | Insurance Coverage Details |
Tenant represents that neither Tenant, nor the principals, officers, partners, and/or members of Tenant: (i) is currently identified on the list maintained by the U.S. Department of the Treasury, Office of Foreign Assets Control ("OFAC"), generally known as the OFAC List" (formerly known as the Specially Designated Nationals and Blocked Persons List); (ii) is currently identified on the lists maintained by the U.S. Department of Commerce (the "DOC List") and/or the U.S. Bureau of Industry and Security (the "BIS List"); (iii) acts for or on behalf of any person or persons listed on the OFAC List, the DOC List, the BIS List, and/or any other known list of denied persons, excluded persons, and excluded entities maintained by the federal agencies of the United States; and (iv) is a person or persons, or acts for or on behalf of any person or persons, with whom a citizen or business of the United States is prohibited to engage in transactions by any trade embargo, economic sanction, or other prohibition of United States law, regulation, or Executive Order of the President of the United States of America. | Government Restrictions | Forms and Endorsements |
Section 14.4 To the extent that any of the terms of this Agreement are inconsistent with the Truck Transportation Act, R.S.O. 1990, c. T.22, as amended, and the Regulations thereto or similar provincial or territorial legislation having jurisdiction, and/or the provisions of any bill of lading, the terms of this Agreement shall prevail. | Legislative Compliance | Inconsistency with Truck Transportation Act |
42F. Landlord’s Access
Tenant covenants and agrees that it will permit Landlord, its agents, servants, employees, licensees, invitees, and contractors, at any and all times during regular business hours, to pass and repass on and through the Premises and basement of the Building, or such portion thereof as may be necessary, in order that they or any of them may gain access to any facilities of the Building for inspection, repairs and alterations as provided herein. Landlord shall provide Tenant , 24 hour advance notice of such entry, and coordinate such entry to avoid disruption of Tenant's business activities. Tenant agrees further that it will, during the entire term of this Lease, keep the Landlord informed of the telephone numbers of at least three persons or parties having keys to the Premises in order that, in the event of an emergency which requires Landlord to have access to the Premises during other than regular business hours, Landlord may arrange with such persons or parties to be admitted to the Premises, provided, however, that if Landlord is unable to arrange for admittance to the Premises during such emergency, or if time does not permit the making of such arrangements, Landlord shall have the right to gain admittance to the demised Premises forcibly or by otherwise breaking into the Premises, and the sole liability of Landlord to Tenant in such event shall be that Landlord shall be obligated to repair all damage caused by such breaking in within a reasonable time after the occurrence thereof and secure the Premises as soon as possible thereafter.
Without limiting Landlord's rights under the foregoing paragraph of this Article, Tenant covenants and agrees that, provided notice of renewal has not been given under Article 72, it will permit
Landlord, its agents, servants, employees, licensees, invitees, and contractors during the last year of the term of this Lease at any and all times during regular business hours, after 24 hour notice to tenant, to pass and repass on and through the Premises, or such portion thereof as may be necessary, in order that they or any of them may gain access to the Premises for the purpose of showing the Premises to potential new tenants or real estate brokers. In addition, Landlord shall be entitled to place a "FOR RENT" or "FOR LEASE" sign (not exceeding 8.5” x 11”) in the front window of the Premises during the last six months of the term of this Lease. | Landlord Access with Notice | Access |
Each party retains the right to determine whether to disclose any Confidential Information to the other party. | Disclosure Rights | No Confidentiality Obligation |
All insurance maintained by Tenant pursuant to this Article shall name Landlord and Landlord’s managing agent as additional insureds and shall name Tenant as the insured, shall provide that any loss shall be payable notwithstanding any act or failure to act or negligence of Landlord, Tenant or any other person, shall provide that no cancellation, reduction in amount, or material change in coverage thereof will be effective until at least thirty days after mailing by the insurer to Landlord of written notice thereof, and shall be satisfactory to Landlord, acting reasonably, in all other respects. All insurance provided for herein shall be obtained under valid and enforceable policies, issued by financially sound and responsible insurance companies authorized, licensed and admitted to do business in the state in which the Premises and building are located and reasonably approved by Landlord. The insurance companies must have a general policy rating of A or better and a financial class of IX or better by AM Best Co., Inc.
Tenant hereby waives any and all rights of recovery against Landlord, its officers, members, agents, and employees, occurring on or arising out of the use and occupation of the Premises or the building to the extent such loss or damage is covered by proceeds received from insurance required under this Lease to be carried. This waiver of subrogation provision shall be limited to loss or damage to the property of Landlord and Tenant and bodily injury to employees, officers, agents of each party and any other injured member of the public. Tenant shall indemnify Landlord against any loss or expense, including reasonable attorneys’ fees, resulting from the failure to obtain such waiver. This waiver shall be in addition to, and not in limitation or derogation of, any other waiver or release contained in this Lease with respect to any loss of, or damage to, property of the parties hereto or bodily injury to either party or to members of the public. Inasmuch as the above waiver will preclude the assignment of any aforesaid claim by way of subrogation to an insurance company, Tenant agrees immediately to give to each insurance company providing a policy described in this Article, written notice of the terms of said waiver, and to have said insurance policies properly endorsed, if necessary, to prevent the invalidation of said insurance coverages by reason of said waiver.
Upon the execution of this Lease and thereafter not less than fifteen days prior to the expiration date of any policy delivered pursuant to this Article, Tenant shall deliver to Landlord the originals of all policies or renewal policies, as the case may be, required by this Lease, bearing notations evidencing the payment of the premiums therefor, which premiums may be paid by Tenant in installments if such payment of premiums by installments is provided for and permitted by such original or renewal policies . In lieu of any such policies, Tenant may deliver certificates of the insurer, in form and substance satisfactory to Landlord, as to the issuance and effectiveness of such policies and the amounts of coverage afforded thereby, accompanied by copies of such policies. Such insurance may be provided through a blanket policy or policies in form and substance satisfactory to Landlord. Such blanket policies shall provide specific allocation to the demised premises of the coverage afforded thereby, and shall give to Landlord no less protection than that which would be afforded by separate policies.
If at any time Tenant shall neglect or fail to provide or maintain insurance or to deliver insurance policies in accordance with this Article, Landlord may effect such insurance as agent for Tenant, by taking out policies in a company satisfactory to Landlord, and the amount of the premiums paid for such
insurance shall be paid by Tenant to Landlord on demand. Landlord, in addition to Landlord's other rights, powers and remedies, shall be entitled to recover as damages for any breach of this Article the uninsured amount of any liability, claim, loss, damage or expense, including reasonable attorneys' fees, suffered or incurred by Landlord, and shall not be limited in the proof of damages which Landlord may claim against Tenant to the amount of the insurance premiums not paid or incurred by Tenant which would have been payable for such insurance. | Tenant Insurance Requirements | Insurance Coverage Details |
70. Additional Rent – Building Maintenance | Building Maintenance | Building Maintenance |
Important Notice Regarding Compensation Disclosure | Compensation Disclosure Notice | Compensation Disclosure |
Women not of childbearing potential may participate and include those who are:
1. infertile due to surgical sterilization (hysterectomy, bilateral oophorectomy or bilateral salpingectomy), congenital anomaly such as mullerian agenesis; or
2. post-menopausal – defined as a woman being amenorrheic for more than 1 year without an alternative medical cause and a serum follicle- stimulating hormone (FSH) level compatible with postmenopausal status. A FSH level in the post- menopausal range may be used to confirm a post- menopausal state in women not using hormonal contraception or hormonal replacement therapy. | Eligibility Criteria | Menopausal Status Requirements |
COVERAGE
PREMIUM | Insurance Premiums | Insurance Coverage Details |
2. Obligations and Restrictions. Each party agrees: (i) to maintain the other party's Confidential Information in strict confidence; (ii) not to disclose such Confidential Information to any third party; and (iii) not to use such Confidential Information for any purpose except for the Purpose. Each party may disclose the other party’s Confidential Information to its employees and consultants who have a bona fide need to know such Confidential Information for the Purpose, but solely to the extent necessary to pursue the Purpose and for no other purpose; provided, that each such employee and consultant first executes a written agreement (or is otherwise already bound by a written agreement) that contains use and nondisclosure restrictions at least as protective of the other party’s Confidential Information as those set forth in this Agreement. | Confidentiality Obligations | Confidentiality Obligations |
(iii) Use the plumbing facilities for any purpose other than that for which they were constructed, or dispose of any garbage or other foreign substance therein, whether through the utilization of so-called “disposal” or similar units, or otherwise; | Use and Garbage Disposal | Use and Garbage Disposal |
Theophyline (Uniphyl) 600 mg qhs – bronchodilator by increasing cAMP used for | Theophyline Bronchodilator | Study Drug |
DELUXE PROP COV PART DECLARATIONS | Deluxe Property Coverage Declarations | Deluxe Property Coverage Declarations |
Electronic vandalism Limitation Endorsement DX T3 98 | Electronic Vandalism Endorsement | Electronic Vandalism Limitation |
clothing and shoes. Get medical attention if symptoms occur. | Safety Warning | Health Requirements |
Hauling corn and soybean meal from Pittsburg to Mt. Pleasant using Vendor’s equipment. | Hauling Services | Hauling Requirements |
COMMON POLICY CONDITIONS-DELUXE | Common Policy Conditions | Common Policy Conditions |
Insurance applies only to a premises location and building number and to a coverage or type of property for which a Specific Limit of Insurance is shown on schedule. | Premises Location Coverage | Specific Limits of Insurance |
Tenant waives trial by jury in any action, proceeding, or counterclaim whatsoever brought by Landlord or Tenant arising out of or in any way connected with this Lease, the relationship of Landlord and Tenant, Tenant’s use of or occupancy of the Premises, and/or any emergency statutory or any other statutory remedy. It is further mutually agreed that in the event Landlord commences any summary proceeding for possession of the Premises, or any other action or proceeding against the Tenant or the Premises, Tenant will not interpose any unrelated counterclaim of whatever nature or description in any such proceeding. | Jury Trial Waiver | Jury Trial Waiver |
Co-insurance provision
Coinsurance does not apply to any Building,Personal Property or “Stock” coverage for which a Specific Limit of Insurance applies as shown on schedule. | Coinsurance Exclusion | Co-Insurance |
This agreement shall continue in force and effect until May 31, 2025 and shall be automatically renewed for successive one-year terms annually thereafter unless notice of non-renewal is given by the Company or the Client before the end of the term. Company shall have the right to modify, reject, or terminate any SOW and any related work in process with five days written notice to Client. In the event Company terminates the SOW prior to completion of Services, the Client shall pay Company the fees due under the SOW with respect to Services completed as of the date of termination. Payment for completed work will be deducted from the deposit. Company will retain the non-refundable 50% of the Deposit and return any unearned portion exceeding 50% of the Deposit. Any amount due for services performed by Company above the deposit will be billed to Client and Client shall promptly pay. | Renewal and Termination Terms | Termination Clause |
As respects Business Income Coverage, for which no other deductible is stated above or in the coverage description, a 72 hour deductible applies. | Business Income Deductible | No Other Deduction or No Deductible |
(B) choose either Landlord's determination or Tenant's determination submitted to the Appraiser as the better estimate of Fair Market Minimum Annual Rent, being the determination which is closer to the Fair Market Minimum Annual Rent determined by the Appraiser using the definition set forth in this Article 72, within thirty (30) days after the date that the Appraiser is designated. The Appraiser's aforesaid choice shall be conclusive and binding upon Landlord and Tenant. Each party shall pay its own counsel fees and expenses, if any, in connection with the procedure described herein, and fifty (50%) percent of any AAA fees and fees of the Appraiser. Either Landlord or Tenant shall have the right to submit to the Appraiser any material in support of its determination of Fair Market Minimum Annual Rent within ten (10) business days of the date of the selection of the Appraiser. After a determination has been made of the Fair Market Minimum Annual Rent, the parties shall execute and deliver a lease amendment memorializing the extension of the Term as described in this Article 72 and setting forth the Rent payable by Tenant during the Renewal Term, but the failure to so execute and deliver any such instrument shall not affect the determination of Fair Market Minimum Annual Rent (and, accordingly, the Rent payable during the Renewal Term). | Determining Fair Market Rent | Appraiser Selection |
The Premium shown above includes the premium charged for Equipment Breakdown coverage. The premium for Equipment Breakdown coverage is $8,359 If you elect not to purchase Equipment Breakdown coverage, please contact your Account Executive and a revised quote without Equipment Breakdown coverage will be sent to you. | Equipment Breakdown Coverage | Equipment Breakdown Coverage |
Notwithstanding any other provision hereof to the contrary notwithstanding, in no event may the Premises be used for any of the following purposes:
(a) the sale, rental or use of amusement devices, pinball machines, electronic computer, card games, games of chance of any kind, or video type amusement machines, games or devices (such as Pacman);
(b) pornographic movie theater or live "sex show" theater;
(c) bowling alley;
(d) billiard parlor or pool hall,;
(e) funeral parlor;
(f) massage parlor;
(g) gasoline station;
(h) sale or rental of pornographic literature (such as an "Adult Book Store");
(i) the sale or rental of video tapes of X-Rated, R-Rated, PG-Rated, Not-rated or any kind of movies or "pornographic" movies;
(j) flea market, bingo or other game hall or meeting room;
(k) drug abuse treatment center;
(l) methadone maintenance clinic or center;
(m) the sale of paraphernalia used in connection with illicit drugs;
(n) any games of chance or gambling, in any form (including, but not limited to horse racing, such as an OTB parlor, but excluding the sale of lottery tickets that are sponsored by federal, state, county or local authorities);
(o) the sale of prescription drugs, cosmetics, health and beauty aid products and pharmaceutical products;
(p) intentionally omitted;
(q) discotheque, ballroom, or dance hall.
The foregoing provisions of this Article shall not be construed or interpreted to enhance or enlarge the uses for which the Premises may be used, which uses are strictly limited to those specifically set forth in this Lease. | Prohibited Use | Prohibited Uses |
If Tenant timely disputes Landlord’s Determination and Landlord and Tenant fail to agree as to the Fair Market Minimum Annual Rent (and, accordingly, the Rent payable by Tenant during the subject Renewal Term) within thirty (30) days after the giving of Tenant’s Notice, then the Fair Market Minimum Annual Rent shall be determined as follows: A licensed real estate appraiser (the “Appraiser”) shall be selected and paid for jointly by Landlord and Tenant. If Landlord and Tenant are unable to agree upon the Appraiser, then the same shall be designated by the American Arbitration Association (“AAA”). The Appraiser selected by the parties or designated by the AAA shall have at least ten (10) years’ experience in the appraisal of retail space in Manhattan, NY. Landlord and Tenant shall each submit to the Appraiser and to the other its determination of the Fair Market Minimum Annual Rent. The parties shall instruct the Appraiser to (A) conduct the hearings and investigations that he or she deems appropriate, and | Fair Market Rent Determination | Applicability of Appraiser |
Duplicate Electronic Data Processing Data and Media | Duplicate Data Storage | Electronic Data Processing |
Personal Property at Undescribed Premises
LIMITS OF INSURANCE
At any “exhibition” premises
Not Covered
At any installation premises or temporary storage premises
Not Covered
At any other not owned, leased or regularly operated premises
$25,000 | Personal Property Limits | Insurance Limits |
Independently Developed Intellectual Property. | Independent IP | Independently Developed Intellectual Property |
It is unlikely that it is caused by a mast cell mediated etiologigy that increases vascular permeability through mast cell degranulation and release of inflammatory mediators include allergic angioedema, autoimmune mast cell release and direct mast cell release caused by medications such as opiates and radiocontrast media. It is not likely this type of reaction because these etiologies are associated with urticaria and pruritis, which the patient did not have. Also the patient did not have any exposure to a new pet, food, lotion or any other allergen or medication that could cause an allergic type reaction. The patient also does not have any history of autoimmune disease or any reaction similar to this in the past | Diagnosis | Health Effects Explanation |
Onsite Services.
2.1 Onsite visits will be charged on a daily basis (minimum 8 hours).
2.2 Time and expenses will be charged based on actuals unless otherwise described in an Order Form or accompanying SOW.
2.3 All work will be executed during regular working hours Monday-Friday 0800-1900. For work outside of these hours on weekdays, Company will charge one hundred percent (100%) of the regular hourly rate and two hundred percent (200%) for Saturdays, Sundays and public holidays applicable to Company.
2.4 If scheduled onsite visits are cancelled less than ten (10) working days in advance of the scheduled date, Company is entitled to charge fifty percent (50%) of the expected revenue associated with this onsite activity as compensation. | Onsite Service Fees | Onsite Visits |
Summary statistics will be presented by treatment and by timing of dose (all 4 combinations of treatment and timing of dose). The GD parameters on the original scale will be analyzed using the mixed-effects model that includes treatment, timing of dose, treatment-by-timing of dose interaction, and period as fixed effects and patient as a random effect. | Data Analysis | Study Summary |
Upon the execution of this Lease, Tenant shall provide Landlord with the name and stock interest of each Shareholder of the Tenant, if it be a corporation, or, name and percentage interest of each Member of the Tenant if it be a Limited Liability Company. Any such corporate tenant, within ten (10) days following Landlord’s written request therefor, shall furnish to Landlord a statement verified by a principal officer of said corporation, setting forth such information regarding the stockholders thereof which Landlord may designate in its said request; it being distinctly understood and agreed that any such Tenant’s failure to comply with Landlord’s said request shall be deemed a major default under the within Lease. | Corporate Tenant Compliance | Corporate Tenant Compliance |
In the event that this Lease is assigned or the Premises are sublet (except for any assignment or subletting which does not result in a change of beneficial ownership of this Lease, of in connection with an Assignment to an affiliate, successor or to a coporation intio which Tenant is merged or consolidated, or to an entity to which substantially all of the assets of Tenant are transferred), it shall be a condition of such assignment or subletting that Tenant shall deposit or arrange for the deposit with Landlord as security hereunder an additional amount equal to two (2) months fixed rent at the rate then in effect for the first assignment or subletting and an additional (2) months fixed rent at the rate then in effect for each and every subsequent assignment or subletting. | Subletting Security Deposit | Security Deposit for Assignment/Sublet |
Umbrella
Policy Number
CUP-001
Policy Term
05/29/2021 – 05/29/2022
Insuring Company
INSURANCEA PROPERTY CASUALTY COMPANY OF AMERICA
Locations schedule | Umbrella Policy Details | Umbrella Policy Details |
If any term, covenant or condition of this Lease or the application thereof to any person or circumstance shall, to any extent, be invalid or unenforceable, the remainder of this Lease, or the application of such term, covenant or condition to persons or circumstances other than those as to which it is held invalid or unenforceable, shall not be affected thereby and each term, covenant or condition of this Lease shall be valid and be enforced to the fullest extent permitted by law. | Severability of Terms | Applicability of Florida Statutes |
Hail:
At the following described premises:
PREMISES
BUILDINGS
LOCATION NO.
No.
2-13
2-19
the following percentage applies: | Hail Damage Percentage | Hail and Insurance Coverage |
++HTN
• Continue patient’s BP control with Diltiazem drip 5mg/hour
• HOLD altace (ACEI) that is most likely the cause of angioedema
• Consider an alternative HTN medication to replace the ACEI. Can’t use a HCTZ because of sulfa allergy. Also has asthma/COPD picture so beta blocker may not work well either. | Hypertension Treatment | HTN Treatment Plan |
Airport Information
Airport:
Runway Surface Type:
Airport Elevation:
Runway Surface Condition:
Runway Used:
IFR Approach:
Runway Length/Width:
VFR Approach/Landing: | Airport Runway Details | Airport Information |
Maximum amount – each building | Building Maximum Amount | Building Maximum Amount |
Notwithstanding any other provision hereof to the contrary notwithstanding, in no event may the Premises be used for any of the following purposes: | Prohibited Use | Permitted Use |
42G. Use Restrictions
Notwithstanding any other provision hereof to the contrary notwithstanding, in no event may the Premises be used for any of the following purposes:
(a) the sale, rental or use of amusement devices, pinball machines, electronic computer, card games, games of chance of any kind, or video type amusement machines, games or devices (such as Pacman);
(b) pornographic movie theater or live "sex show" theater;
(c) bowling alley;
(d) billiard parlor or pool hall,;
(e) funeral parlor;
(f) massage parlor;
(g) gasoline station;
(h) sale or rental of pornographic literature (such as an "Adult Book Store");
(i) the sale or rental of video tapes of X-Rated, R-Rated, PG-Rated, Not-rated or any kind of movies or "pornographic" movies;
(j) flea market, bingo or other game hall or meeting room;
(k) drug abuse treatment center;
(l) methadone maintenance clinic or center;
(m) the sale of paraphernalia used in connection with illicit drugs;
(n) any games of chance or gambling, in any form (including, but not limited to horse racing, such as an OTB parlor, but excluding the sale of lottery tickets that are sponsored by federal, state, county or local authorities);
(o) the sale of prescription drugs, cosmetics, health and beauty aid products and pharmaceutical products;
(p) intentionally omitted;
(q) discotheque, ballroom, or dance hall.
The foregoing provisions of this Article shall not be construed or interpreted to enhance or enlarge the uses for which the Premises may be used, which uses are strictly limited to those specifically set forth in this Lease. | Prohibited Uses List | Prohibited Uses Restriction |
For the purposes of this Article, and elsewhere in this Lease, (i) the term "Persons Within Tenant's Control" shall mean and include Tenant, all of Tenant's respective principals, officers, agents, contractors, servants, employees, licensees and invitees; (ii) the term "Requirements" shall mean all present and future laws, ordinances, requirements, orders, directives, rules and regulations of federal, state, county and city governments and of all other governmental authorities having or claiming jurisdiction over the Real Property relating solely to the Premises; (iii) the term "Indemnitees" shall mean Landlord, its trustees, partners, shareholders, officers, directors, employees, agents and contractors and the managing agent, if any (and the partners, shareholders, officers, directors and employees and contractors of such managing agent), of Landlord; and (v) the term "Governmental Authority" shall mean The United States of America, the City and State of New York, the County of New York, any political subdivision thereof and any agency, department, commission, board, bureau or instrumentality of any of the foregoing, now existing or hereafter created, having jurisdiction over the Building, the Real Property, or any portion thereof. | Persons Within Control, Requirements, Indemnitees | Transfer Restrictions |
Notwithstanding anything contained to the contrary in this lease, (i) Tenant hereby waives any right to recover against Landlord any indirect, consequential, special, punitive or incidental damages against Landlord in any cause of action, proceeding or claim arising out of, or in connection with, this lease; and (ii) Landlord hereby waives any right to recover against Tenant any indirect, consequential, special, punitive or incidental damages against Tenant in any cause of action, proceeding or claim arising out of, or in connection with, this lease. | Waiver of Damages | Waiver of Indirect and Consequential Dam |
77 yo woman presents with significant angioedema in left side of tongue and inner cheek. Possible causes of angioedema include allergic anaphylaxis reaction, drug induced, allergic contact dermatitis, viral infection, drug induced, or a C1 inhibitor deficiency disorder acquired or hereditary. Laryngeal edema can also be caused by tonsillitis, peritonsilar abscess or pharyngeal foreign body.
It is unlikely that the patient has edema caused by abscess or tonsillitis since she does not have any associated fever or other signs of infection and the sudden onset of her swelling also argues against this. It is not likely a foreign body since ENT did not find anything when they scoped her.
It is unlikely that it is caused by a mast cell mediated etiologigy that increases vascular permeability through mast cell degranulation and release of inflammatory mediators include allergic angioedema, autoimmune mast cell release and direct mast cell release caused by medications such as opiates and radiocontrast media. It is not likely this type of reaction because these etiologies are associated with urticaria and pruritis, which the patient did not have. Also the patient did not have any exposure to a new pet, food, lotion or any other allergen or medication that could cause an allergic type reaction. The patient also does not have any history of autoimmune disease or any reaction similar to this in the past
It is more likely that the etiology is kinin-related where angioedema results from generation of bradykinin and complement-derived mediators that increase vascular permeability since there is no urticaria or pruritis. The most likely cause is the Altace (ACEI) that the patient has been taking caused an increase in bradykinin since it decreases angiotensin 2 which degrades bradykinin. Bradykinin can then interact with vascular receptors increasing vasodilation, vascular permeability, increased cGMP and release of nitric oxide. This reaction occurs in .1-7% of patients treated with an ACEI and it typically involves the mouth, lips, tounge, larynx, pharynx and sublottic tissues. Half of these cases usually occur within a week of starting the ACEI but can occur years later. This is a class specific reaction not a drug specific and ARBs can cause the same reaction even though these drugs don’t effect the kinin metabolism. 50% of patients with angioedema due to an ARB also had an ACEI induced angioedema (Cicardi, M, Zingale, LC, Bergamschini L, Agostoni, A. Angioedema associated with agniotensin-converting enzyme inhibitor use: outcome after switching to a different treatment. Arch Intern Med 2004; 164:910). Deficiency of C1 inhibitor can cause angioedema since levels of complement are reduced and cause increased bradykinin. This can be due to lack of C1 INH or adequate amounts of nonfunctional C1 INH. Other causes of angioedema include aspirin and NSAIDs since inhibition of cox and enzyme pathyway increases formation of pro-inflammatory leukotrienes.
Other possibilities in the differential of causes of swelling include cellulitis, autoimmune conditions including SLE, polymyositis, dermatomyositis and sjorgren’s syndrome. Hypothyroidism can cuase puffiness of face and lips, hyperthyroidism can cause an infiltrative dermopathy, superior vena cava syndrome and tumors can cause venous engorgement and swelling. It is not likely one of these etiologies since the patient is on an ACEI and the swelling is restricted only to her tongue and throat typical of ACEI angioedema. | Allergic Angioedema | Angioedema Explanation |
Review of Systems:
Constitutional - NAD, has been generally feeling well the last couple of weeks Eyes - no changes in vision, double vision, blurry vision, wears glasses ENT - No congestion, changes in hearing, does not wear hearing aids Skin/Breast - no rashes Cardiovascular - No SOB, chest pain, heart palpitations Pulmonary - hard to get a breath in but not short of breath, no cough Endocrine - No changes in appetite Gastro Intestinal - No n/v/d or constipation. Has not eaten because can't swallow solid
foods.
Genito Urinary - No increased frequency or pain on urination. Some urge incontinence
with history of prolapse. Musculo Skeletal - no changes in strengths, no joint tenderness or swelling Neurologic - No changes in memory Psychology - No changes in mood Heme/Lymph - Denies easy bruising | No Changes in Symptoms | Neurological Exam Findings |
as specified in Regulation 32 of the Securities and Futures (Offers of Investments) (Shares and Debentures) Regulations 2005 of Singapore. | Applicable Regulation | Singapore Regulatory Compliance |
TSH level to check for hypo/hyper thyroid | Thyroid Function Test | TSH Test |
Reasonable Consent. If Landlord does not elect either of the options provided in the Recapture section of this article, Landlord shall not unreasonably withhold or delay its consent to a proposed transfer. It shall be deemed reasonable for Landlord to withhold consent to any proposed transfer if any of the following conditions have not been established to Landlord's satisfaction:
6.4.1 The proposed transferee has sufficient financial wherewithal to discharge its obligations under this Lease as determined by Landlord's criteria for selecting Project tenants and has a tangible net worth, experience, and reputation that is not less than the tangible net worth, experience, and reputation of Tenant on the Date of this Lease or the date of the transfer, whichever is greater. "Tangible net worth" shall mean the excess of the value of tangible assets (i.e. assets excluding those which are intangible such as goodwill, patents and trademarks) over liabilities.
6.4.2 The use, nature, business, activities, or reputation in the business community of the proposed transferee will not cause physical harm to the Project or harm to the reputation of the Project that would result in an impairment of Landlord's ability to lease space in the Project or a diminution in the rental value of space in the Project.
6.4.3 The proposed use of the Premises by the proposed transferee will be the Permitted Use and not prohibited by the Rules and Regulations, and will not violate any restrictive covenants or exclusive use provisions applicable to Landlord, cause a violation of another lease for space in the Project, or give an occupant of the Project a right to cancel its lease.
6.4.4 The proposed transferee shall not be any person or entity who shall at that time be a tenant, subtenant, or other occupant of any part of the Project, or an affiliate of any of them, or who dealt with Landlord or Landlord's agent (directly or through a broker) as to space in the Project during the six months immediately preceding Tenant's request for Landlord's consent.
6.4.5 The proposed use of the Premises by the proposed transferee will not require alterations or additions to the Premises or the Project to comply with applicable law or governmental requirements and will not negatively affect insurance requirements or involve the introduction of materials to the Premises that are not in compliance with applicable environmental laws.
6.4.6 Any mortgagee of the Project will consent to the proposed transfer if such consent is required under the relevant loan documents.
6.4.7 The proposed use of the Premises will not materially increase the operating costs for the Project or the burden on Project services, or generate excessive foot traffic, elevator usage, Parking Area usage, or security concerns in the Project, or compromise or reduce the comfort or safety, or both, of Landlord and the other occupants of the Project.
6.4.8 The proposed transferee shall not be, and shall not be affiliated with, anyone with whom Landlord or any of its affiliates or mortgagees has been involved with in litigation or who has defaulted under any agreement with Landlord or any of its affiliates.
6.4.9 There shall be no default by Tenant, beyond any applicable grace period, under any of the terms, covenants, and conditions of this Lease at the time that Landlord's consent to a transfer is requested and on the date of the commencement of the term of the proposed transfer.
6.4.10 If the resulting tenant entity does not have equal or greater tangible net worth and creditworthiness as Tenant as of the Date of this Lease or the date of transfer, whichever is greater, Landlord, at its option, may approve the transfer subject to an increase in the Security Deposit, or receipt of new personal guarantees acceptable to Landlord, or both.
6.4.11 Any Guarantor will consent to the transfer and to execute a written agreement reaffirming the | Reasonable Consent Requirements | Consent Requirements |
Business Personal Property Rate: | Business Personal Property Rate | Business Personal Property Tax Rate |
(B) choose either Landlord's determination or Tenant's determination submitted to the Appraiser as the better estimate of Fair Market Minimum Annual Rent, being the determination which is closer to the Fair Market Minimum Annual Rent determined by the Appraiser using the definition set forth in this Article 72, within thirty (30) days after the date that the Appraiser is designated. The Appraiser's aforesaid choice shall be conclusive and binding upon Landlord and Tenant. Each party shall pay its own counsel fees and expenses, if any, in connection with the procedure described herein, and fifty (50%) percent of any AAA fees and fees of the Appraiser. Either Landlord or Tenant shall have the right to submit to the Appraiser any material in support of its determination of Fair Market Minimum Annual Rent within ten (10) business days of the date of the selection of the Appraiser. After a determination has been made of the Fair Market Minimum Annual Rent, the parties shall execute and deliver a lease amendment memorializing the extension of the Term as described in this Article 72 and setting forth the Rent payable by Tenant during the Renewal Term, but the failure to so execute and deliver any such instrument shall not affect the determination of Fair Market Minimum Annual Rent (and, accordingly, the Rent payable during the Renewal Term).
(iii) If Tenant timely disputes Landlord’s Determination and if the final determination of the Fair Market Minimum Annual Rent shall not be made on or before the first day of the subject Renewal Term then, pending such final determination, Tenant shall pay, as Rent for the subject Renewal Term, an amount equal to Landlord’s Determination. If, based upon the final determination of the Fair Market Minimum Annual Rent, the Rent payments made by Tenant for such portion of the subject Renewal Term were (i) less than they should have been, then Tenant shall pay to Landlord the amount of such deficiency within ten (10) business days after demand therefor, or (ii) greater than they should have been, then Landlord shall credit the amount of such excess against installments of Rent next coming due.
Time shall be of the essence with respect to all obligations under this Article 72. | Determining Fair Market Rent | Appraiser Selection |
Tenant shall as its sole responsibility, and at Tenant's sole cost and expense, take all action, including making any required alterations necessary to comply with all Requirements (including, but not limited to, applicable terms of the Americans With Disabilities Act of 1990 (the "ADA"), as modified and supplemented from time to time, which shall impose any violation, order or duty upon Landlord or Tenant arising from, or in connection with, the Premises, Tenant's occupancy, use or manner of use of the Premises (including, without limitation, any occupancy, use or manner of use that constitutes a "place of public accommodation" under the ADA), or any installations in the Premises, or required by reason of a breach of any of Tenant's covenants or agreements under this Lease, whether or not such Requirements shall now be in effect or hereafter enacted or issued, and whether or not any work required shall be ordinary or extraordinary or foreseen or unforeseen at the date hereof. | ADA Compliance Requirements | Requirements |
InsuranceA Risk Control is an innovative provider of cost-effective risk management services and products. As one of the largest Risk Control departments in the industry, our scale allows the right resource at the right time to meet customer needs. For over 110 years, our loss prevention professionals have assisted agents, brokers and customers across the country and around the world.
https://www.InsuranceA.com/risk-control | Risk Management Services | Coverage Options |
Fluticasone (Flovent) 2 puff bid - corticosteroid to treat airways in asthma/copd xoperex 1.25mg and Ipratropium 2.5 ml nebulized qam - anticholinergic to treat airways
in COPD | Asthma/COPD Medications | Fluticasone (Flovent) and |
Tenant, and/or Tenant's employees may not smoke in any part of the Building, including but not limited to the Premises, bathrooms, fire escapes and hallways of the Building. Furthermore, Tenant and/or its employees may not smoke in front of the entrance of the Building. Landlord has the right to involve the NYC Fire Department and/or any other agencies of the City of New York if Tenant and/or its employees, and/or invitees are found to have been smoking in or around the Premises. A violation of this Article shall be material default under this Lease. | No Smoking Policy | Smoking and Smoking Restrictions |
Coinsurance does not apply to any Building,Personal Property or “Stock” coverage for which a Specific Limit of Insurance applies as shown on schedule. | Coinsurance Exclusion | Coinsurance |
Landlord’s failure during the Lease term to prepare and deliver any of the statements, notices, or bills for rent and/or additional rent or Landlord’s failure to make a demand, shall not in any way cause Landlord to forfeit or surrender its rights to collect any of the items of rent and/or additional rent that may have become due during the term of this Lease. Tenant’s liability for all such amounts due under this Lease shall survive the expiration of the Term. Nevertheless, any sums due under the Lease must be claimed within two years of when due or within one year from expiration of the Lease. | Rent and Additional Rent Liability | No Forfeiture |
In the event that the Premises are not surrendered at the end of the Lease term, Tenant shall indemnify Landlord against loss or liability resulting from Tenant's delay in surrendering the Premises thereafter until said Premises are surrendered. | Non-Surrender of Premises Indemnity | Surrender of Premises |
Deluxe business income (AND extra expense) coverage form - described premises
PREMISES LOCATION NO.
BUILDING NO.
LIMITS OF INSURANCE
2-13
2-19
$9,038,112 | Business Income Coverage Details | Coverage Options |
• Consider an alternative HTN medication to replace the ACEI. Can’t use a HCTZ because of sulfa allergy. Also has asthma/COPD picture so beta blocker may not work well either. | Hypertension Medication Alternatives | Medication Use |
PricewaterhouseCoopers LLP
300 Madison Avenue New York, New York 10017 United States of America | PricewaterhouseCoopers LLP Address | Applicability of Law |
12.4 Force Majeure. Force Majeure. Neither party shall be liable for any failure or delay in performance under this Agreement for causes beyond that party’s reasonable control and occurring without that party’s fault or negligence, including, but not limited to, acts of God, acts of government, flood, fire, civil unrest, acts of terror, strikes or other labor problems (other than those involving Client or Client employees, respectively). Dates by which performance obligations are scheduled to be met will be extended for a period of time equal to the time lost due to any delay so caused. | Force Majeure Clause | Force Majeure |
The Security being held pursuant to this Article shall at all times be an amount equal to
three (3) times the monthly fixed rent then reserved under Article 40 of this Lease. On the first day of the month following each anniversary of the Rent Commencement Date of this Lease, Tenant shall pay to Landlord funds sufficient so that the un-applied Security held by Landlord shall at all times equal three times the monthly fixed rent then reserved under Article 40 of this Lease. | Security Deposit Amount | Security |
The Limits of Insurance shown in the left column are included in the coverage form and apply unless a Revised Limit of Insurance or Not Covered is shown in the Revised Limits of Insurance column on the right. The Limits of Insurance apply in any one occurrence unless otherwise stated. | Limits of Insurance | Limits of Insurance |
Tenant shall pay all charges for all public or private utility services provided to the Premises, shall comply with all contracts relating to such services, and shall do all other things required for the maintenance and continuance of all such services.
Tenant, at its sole cost and expense, shall make all arrangements with the public utility company serving the Premises for obtaining and paying for heat and electricity at the Premises, including without limitation arrangements pertaining to the installation and use of meters, pans, risers, wiring, panel boards, feeders and other conductors and equipment. Landlord shall not be liable or responsible for charges for electricity at the Premises, or any loss, damage or expense which Tenant may sustain or incur if either the quantity or character of electric service is changed or is no longer available or suitable for
Tenant's requirements. At all times during the term of this Lease, Tenant shall comply with all rules and regulations of governmental authorities and the public utility applicable to service, equipment, wiring and changes in requirements. | Utility Services Compliance | Tax and Expense Payments |
50. Licenses and Permits
Tenant agrees to secure and maintain as its sole responsibility and, at its own expense, all licenses and permits from Federal, State, and local authorities as may be necessary for the conduct of Tenant's business, and shall comply with all applicable laws, rules and regulations. Landlord does not represent that any license or permit, which may be required will be granted or, if granted, will continue in effect or be renewed. Tenant's obligations under this Lease shall in no way be affected by Tenant's inability to secure or maintain any license or permit. Landlord will cooperate with Tenant in obtaining any such licenses or permits. | Licenses and Permits Obligation | License and Permit Requirements |
BANK OR OFFICE -
TX
11/17
61217
BUILDINGS OR PREMISES - BANK OR OFFICE -
Prem/Ops.
36,691
43.485
$1,596
TX
12/18
46606
PARKING - PUBLIC - SHOPPING CENTERS - MAINTAINED BY THE LESSEE (LESSOR'S RISK ONLY)
Prem/Ops.
150,000
18.168
$2,725
TX
12/18
61217
BUILDINGS OR PREMISES - BANK OR OFFICE -
Prem/Ops.
112,772
52.752
$5,949
TX
13/19
61217
BUILDINGS OR PREMISES - BANK OR OFFICE -
Prem/Ops.
47,000
52.752
$2,479
TX
14/20
61217
BUILDINGS OR PREMISES - BANK OR OFFICE -
Prem/Ops.
36,691
52.752
$1,936 | Bank or Office Insurance | Building Coverage Details |
General Aggregate
$4,000,000
Products/Completed Operations
$2,000,000
and/or Professional Liability
$2,000,000 (if applicable)
Each Occurrence
$1,500,000
Automobile Liability
Combined Single Limit
$1,000,000
Workers Compensation
Statutory
Employers’ Liability
Each Accident
$250,000
Policy Limit
$100,000
Each Employee
$100,000 | Insurance Coverage Limits | Insurance Coverage Details |
EMPLOYEE BENEFITS LIABILITY COV FORM | Employee Benefits Liability Coverage | Forms and Endorsements |
Tenant shall pay all charges for all public or private utility services provided to the Premises, shall comply with all contracts relating to such services, and shall do all other things required for the maintenance and continuance of all such services. | Utility Services Compliance | Tax and Utility Payments |
PRESENTED BY
PROPOSED ON 05/14/2021 FOR
InsA LLC
NO1 REAL ESTATE INC.
Street 1, SUITE 100
Road 2, SUITE 400
City, State, Zip Code
City, State, Zip Code | Proposed for InsA LLC | Building Coverage Details |
Tenant shall pay to Landlord, as additional rent, $75.00 per month on the first day of each and every month commencing with the Commencement Date, for the term of this Lease, for sprinkler service. | Sprinkler Service Fee | Sprinkler Service Fee |