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200 | Показано, что несмотря на дискуссии о поэтическом языке в церковной среде XIV в., он очевидно продолжает восприниматься как мощный культурный инструмент. | [
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201 | Исследование рукописей «Эдды» показало, что поэтический язык был понятен переписчикам рукописей даже в XIV в., а сами они были знакомы с поэтической традицией. | [
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202 | Культурная ориентация на норвежские (западноевропейские) образцы и преобладающее влияние письменной культуры, вероятно, способствуют разрушению традиционного поэтического языка. | [
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203 | В диссертации применяется комплексный подход, в соответствии с которым использование поэтического языка в Исландии XI–XIV вв. | [
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204 | рассматривается как социокультурная практика, что открывает новую перспективу для исследования средневековых скандинавских обществ. | [
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205 | Кроме того, в диссертации впервые предпринимается масштабный анализ скальдических компетенций и стратегий работы с поэтическим материалом переписчиков рукописей «Эдды» Снорри Стурлусона. | [
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206 | Результаты исследования могут быть использованы для проектирования лекционных курсов, спецкурсов и спецсеминаров по источниковедению, палеографии, истории средневековой скандинавской и конкретно исландской культуры, а также практических занятий по древнеисландскому языку. | [
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207 | Цель исследования. | [
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208 | Разработать алгоритм дифференцированного подхода к эндоваскулярному лечению спинальных артериовенозных мальформаций. | [
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209 | Задачи исследования.1.Изучить особенности клинического течения заболевания в зависимости от типа спинальных артериовенозных мальформаций. | [
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210 | 2.Определить критерии отбора пациентов для интраоперационного проведения нейрофизиологического мониторинга и провокационных тестов на основании селективной спинальной ангиографии.3.Определить тактику эндоваскулярной эмболизации спинальных артериовенозных мальформаций с учетом результатов интраоперационного нейрофизиологического мониторинга и провокационных тестов 4.Оценить радикальность эндоваскулярного лечения спинальных артериовенозных мальформаций и динамику миелопатии в раннем и отдаленном послеоперационном периодах на основании данных селективной спинальной ангиографии и МРТ-исследования. | [
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211 | 5.Оценить клинические результаты предложенного дифференцированного подхода к эндоваскулярному лечению спинальных артериовенозных мальформаций в раннем и отдаленном послеоперационном периодах. | [
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212 | Научная новизна: 1.Систематизированы клинические и диагностические данные при лечении СпАВМ для оптимизации хирургической тактики. | [
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213 | 2.Впервые определены показания для интраоперационного применения провокационных тестов и нейрофизиологического мониторинга, основанные на результатах селективной спинальной ангиографии. | [
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214 | 3.Впервые предложен алгоритм дифференцированного подхода к эндоваскулярному лечению СпАВМ, учитывающий ангиоархитектонику мальформации, результаты интраоперационного нейрофизиологического мониторинга и провокационных тестов. | [
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215 | Штамм мицелиального гриба Penicillium verruculosum B1-151-221 (ВКМ F-3972) (Talaromyces verruculosus) является промышленным продуцентом целлюлаз с продуктивностью до 60 г белка на литр культуральной жидкости. | [
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216 | Однако, улучшение производственных характеристик продуцентов ФП, остаётся актуальной задачей биотехнологии. | [
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217 | Одним из современных подходов для решения этой задачи является модификация механизмов регуляции транскрипции генов целлюлаз. | [
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218 | Цель диссертационной работы состояла в изучении механизма регуляции транскрипции генов целлюлаз в мицелиальном грибе P. verruculosum для улучшения его производственных характеристик, таких как продуктивность, продолжительность культивирования, состав и гидролитическая способность секретируемого комплекса. | [
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219 | В результате было установлено, что транскрипционные факторы Сlr1, Сlr2 и XlnR активируют транскрипцию генов целлюлаз у мицелиального гриба P. verruculosum, а транскрипционный фактор TacA является репрессором транскрипции генов целлюлаз, и его нокаут приводит к значительному повышению авицелазной активности уже на 4-ые сутки культивирования. | [
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220 | На основе штамма P. verruculosum ?tacA, был создан штамм с экспрессией ?-глюкозидазы Aspergillus niger, - продуцент ФП с 1.5 раза большей гидролитической способностью по отношению к микрокристаллической целлюлозе, чем ФП В1-221-151. | [
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221 | Объект исследования – сохранение культурного наследия. | [
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222 | Цель работы - выявление роли цифровой среды в становлении новых культурных форм и практик сохранения культурного наследия на материале анализа культурной деятельности Сибирского федерального университета. | [
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223 | Использованы общенаучные методы исследования: аналитический, синтетический, метод сравнения, функциональный, описательный, сравнительный, информационный подходы, эмпирические методы познания. | [
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224 | Предложен теоретико-методологический принцип культурологического анализа цифровой среды в материально-техническом, функционально-деятельностном и информационно-коммуникативном аспектах, разработано определение репрезентации культурного наследия на базе синтетической теории культуры как идеалообразования, выявлены новые актуальные и динамично развивающиеся форматы культурной деятельности Сибирского федерального университета, связанные а) с комплексным развитием цифровых социокультурных проектов, б) с разработкой новых образовательных программ для подготовки кадров, обладающих цифровыми компетенциями в сфере сохранения культурного наследия, и в) с активным становлением российских цифровых гуманитарных исследований, выполнен культурологический анализ 26 репрезентативных проектов Сибирского федерального университета для сохранения культурного наследия в цифровой среде, в том числе, раскрыты культурное значение и культурные смыслы проекта «Мемориал Победы». | [
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225 | Актуальность темы исследования. | [
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226 | Демографическая ситуация в нашей стране прогрессивно ухудшается, по официальным данным государственной статистики при самом благополучном прогнозе, составленном до 2035 года, естественный прирост населения будет равняться 0,2 на 1000 человек населения. | [
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227 | Для решения демографических государственных задач необходим комплексный подход, учитывающий различные стороны малодетности. | [
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228 | Психологические особенности женщин, имеющих репродуктивные сложности, связаны с возможностью зачатия ребенка. | [
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229 | Научная новизна исследования определяется комплексным подходом к беременности с точки зрения здоровьесберегающего поведения и его связи с психологической готовностью к родительству, а также личностными и индивидуально-психологическими особенностями женщин. | [
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230 | Разработанный дизайн исследования позволяет изучить и расширить имеющиеся научные знания и практический опыт в области готовности к материнству. | [
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231 | Данное исследование является одним из первых на российской выборке, изучающих различные аспекты здоровьесберегающего поведения в период подготовки к беременности и вынашиванию ребенка. | [
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232 | Уточнены теоретические аспекты и выделены особенности проявления информальной экономики в ЛЗП современной России, повлиявшие на ее состояние в институциональных границах на отраслевом и региональном уровнях, позволившие сформировать механизм снижения влияния информальной экономической деятельности в ЛЗП. | [
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233 | Введено авторское определение информальной экономики ЛЗП, имеющее самостоятельное значение в функционировании лесной отрасли, позволившее выявить проблему несогласованности экономических интересов субъектов лесных отношений. | [
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234 | Предложена авторская методика оценки размера информальной экономики в ЛЗП региона. | [
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235 | Обоснована система показателей, методика их расчета, выполнен анализ динамики индикаторов, проведено сопоставление фактических значений с пороговыми, что позволило выявить тенденции нарастания или сокращения факторов, способствующих росту либо снижению уровня информальной экономики в ЛЗП. | [
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236 | Усовершенствована предложенная автором диссертации экономическая модель институциональных преобразований арендных отношений, обеспечивающая последовательный переход на интенсивную модель лесопользования за счет роста арендной платы и перераспределения функций между государством (собственником лесов) и бизнесом (арендаторами) на примере Иркутской области, посредством чего повышается экономическая заинтересованность каждого субъекта лесных отношений выполнять те функции, которые способствуют реализации его цели. | [
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237 | Цель исследования, установление и описание механизмов изменчивости гидрометеорологических параметров на различных пространственно-временных масштабах на Южном Урале в современный и исторический период, а также оценка влияния региональных климатических изменений на динамику и функционирование природных систем. | [
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238 | Решена крупная научная проблема – определение тенденций изменения температурного режима, атмосферных осадков на Южном Урале и водного режима рек Белая и Урал под влиянием глобальных изменений климата и выявление их возможных механизмов. | [
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239 | Проведен комплексный анализ изменения климата на территории Южного Урала, рассмотрены процессы вариаций приземной температуры, осадков и стока рек Южного Урала. | [
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240 | Отслежены и идентифицированы климатические изменения на Южном Урале как в течение периода стационарных наблюдений, так и для более длительных временных периодов. | [
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241 | Получены новые оригинальные решения и результаты по изучению климата региона. | [
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242 | Рассмотрены особенности структурного построения и функционирования инклинометрических устройств в условиях внешних крутильных возмущений. | [
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243 | Разработаны новые математические модели инклинометрических устройств и выполнен анализ динамических погрешностей. | [
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244 | Приведена методика идентификации корректирующих параметров с учетом различных вариантов последовательностей опросов акселерометрических и феррозондовых датчиков, предложена методика адаптивной коррекции динамических погрешностей, основанная на верификации численных значений. | [
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245 | Разработано соответствующее программно-алгоритмическое обеспечение, которое позволяет осуществлять коррекцию измеряемых сигналов с датчиков и снизить динамические погрешности инклинометрических устройств. | [
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246 | Цель: формирование комплексного научного представления об объективности судебного разбирательства с определением её составных элементов, места в системе правовых норм и взаимодействия с основными принципами гражданского судопроизводства. | [
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247 | Объект: общественные отношения, возникающие, изменяющиеся и прекращающиеся между судом и иными участниками в процессе рассмотрения и разрешения гражданских дел, оказывающие влияние на объективность судебного разбирательства. | [
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248 | Методы: общенаучные и частнонаучные методы. | [
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249 | Научная новизна: предложено решение научной задачи, связанной с определением места, сущности и содержания объективности судебного разбирательства в гражданском процессе, и имеющей значение для развития науки гражданского процессуального права. | [
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250 | Достигнуты результаты: разработаны новые научно-обоснованные теоретические и практические предложения об объективности судебного разбирательства в гражданском судопроизводстве как о принципе гражданского процесса, содержание которого составляют действия беспристрастного суда, добросовестное поведение лиц, участвующих в деле, и результат этих действий. | [
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251 | Внедрение: результаты могут быть применены для дальнейшего доктринального изучения соответствующей проблематики, использованы в правотворческой и правоприменительной работе, а также в образовательной деятельности. | [
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252 | Эффективность: разработанные положения имеют научно-прикладное значение ввиду возможного совершенствования норм, регулирующих порядок взаимодействия суда и лиц, участвующих в деле, в процессе установления фактических обстоятельств дела с целью гарантирования правильного и своевременного судебного разбирательства, а также эффективности судебной защиты нарушенных или оспариваемых прав и законных интересов заинтересованных лиц. | [
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253 | Область применения: научно-исследовательская, правотворческая, правоприменительная и образовательная деятельность. | [
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254 | Целью исследования являлось выявление наиболее информативных параметров оксидативного статуса у пациентов с шизофренией, ассоциированных с выраженностью клинико-психопатологической симптоматики и нейрокогнитивного дефицита. | [
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255 | Объект исследования – 125 пациентов с шизофренией и 75 здоровых добровольцев. | [
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256 | Пациенты были разделены на две группы: 70 человек с длительностью заболевания не более 3 лет и 55 человек с длительностью заболевания более 3 лет. | [
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257 | Предмет исследования – оценка выраженности редокс-дисбаланса у пациентов с шизофренией, его ассоциация с клинической симптоматикой, проводимой фармакотерапией и перспективы коррекции имеющихся нарушений. | [
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258 | Работа выполнена в соответствии с принципами доказательной медицины и включает использование клинического, психометрического, лабораторного и статистического методов. | [
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259 | В результате проведенного исследования выявлено, что биохимические маркеры оксидативного стресса ассоциированы с шизофренией и половозрастными показателями. | [
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260 | Маркеры оксидативного стресса в периферической крови ассоциированы с клинико-психопатологическими и нейрокогнитивными особенностями пациентов с шизофренией. | [
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261 | У пациентов с шизофренией с большей длительностью заболевания наблюдаются более высокие уровни продуктов перекисного окисления липидов и белков, в отличие от антиоксидантов, которые демонстрируют пиковую активность. | [
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262 | Приступообразно-прогредиентный и непрерывный тип течения заболевания являются неблагоприятными факторами в отношении выраженности оксидативного стресса у пациентов с шизофренией. | [
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263 | Параметры оксидативного стресса ассоциированы с выраженностью продуктивной, общепсихопатологической симптоматики, побочных эффектов, социальным функционированием, когнитивными показателями. | [
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264 | Доза и поколение антипсихотика, прием корректоров оказывает второстепенное влияние на выраженность оксидативного стресса у пациентов с шизофренией. | [
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265 | Антиоксидант N-ацетилцистеин может рассматриваться в качестве потенциального средства редукции клинико-психопатологической симптоматики, улучшения нейрокогнитивного профиля, восстановления социального функционирования, редукции экстрапирамидных побочных эффектов основной фармакотерапии у пациентов с шизофренией. | [
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266 | На основании полученных данных сформулированы рекомендации, которые могут быть использованы в проведении лечебно-профилактической работы, а также в образовательных циклах и различных курационных мероприятиях в медицинских учреждениях Северо ? | [
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267 | Западного федерального округа. | [
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268 | Цель работы: повышение эффективности и качества процесса конструкторской подготовки производства грузоподъемных машин (ГПМ) путем снижения его трудоемкости на основе информационной поддержки аналогового проектирования. | [
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269 | Объект исследования: процесс конструкторской подготовки производства грузоподъемных машин. | [
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270 | Предмет исследования: методики и инструментарий повышения эффективности процесса конструкторской подготовки производства грузоподъемных машин. | [
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271 | Научная новизна: формализованы взаимосвязи показателей качества ГПМ (ресурсоемкость, долговечность и уровень унификации) и ее основных технических характеристик на стадии конструкторской подготовки производства, разработаны концепция повышения эффективности и качества процесса конструкторской подготовки производства ГПМ, методики: квалиметрической оценки близости цифровых двойников-аналогов проектируемой ГПМ, анализа требований к ГПМ, установленных потребителем, анализа надежности ГПМ на стадии конструкторской подготовки производства. | [
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272 | Цель работы: совершенствование инструментария обеспечения качества проектирования и производства машиностроительной продукции, базирующегося на обеспечении требуемого уровня технической совместимости элементов технической системы, необходимого для повышения степени удовлетворенности потребителя. | [
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273 | Объект исследования: степень удовлетворенности потребителя качеством машиностроительной продукции, определяемым достижимым уровнем показателей технической совместимости элементов системы. | [
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274 | Предмет исследования: взаимосвязь степеней удовлетворенности потребителя качеством продукции с достигнутым уровнем технической совместимости, зависящей от уровней стабильности технологических процессов. | [
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275 | Научная новизна: формализация взаимосвязей параметров технической совместимости, степени удовлетворенности потребителя качеством технических систем и потерь, связанных с вариабельностью выходных характеристик ввиду естественной нестабильности производственных процессов. | [
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276 | Диссертация посвящена изучению особого класса словосочетаний, где как минимум одно из слов содержит сенсорный компонент, при этом сенсорное слово не служит для обозначения объективно присущих свойств. | [
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277 | В качестве материала исследования послужили два параллельных корпуса. | [
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278 | В первый корпус вошли оригинальный текст стихотворения А. Рембо «Пьяный корабль» на французском языке и 15 его переводов на русский язык. | [
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279 | Во второй корпус вошли оригинальный текст романа «Лолита» В. Набокова на английском языке (1955), русский автоперевод (1967) и два французских перевода — Эрика Каана (1959) и Мориса Кутюрье (2001). | [
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280 | Цель работы — дать системное семантическое описание класса словосочетаний с сенсорными семантическими компонентами, используя данные корпусов. | [
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281 | Актуальность работы определяется растущим интересом исследователей к сенсорной лингвистике и смежным направлениям (например, изучению языковой синестезии), и относительно малой степенью научной разработанности ряда вопросов в рамках этой дисциплины, в том числе и в области семантики. | [
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282 | Научная новизна определяется тем, что в работе в качестве объекта исследования вводится класс словосочетаний с сенсорными семантическими компонентами; эти словосочетания исследуются на материале параллельных мультиязычных корпусов (русский, французский и английский языки); предлагается система деления словосочетаний с сенсорными семантическими компонентами на синестетические, моностетические и идеастетические в зависимости от количества и модальности задействованных компонентов, что позволяет разграничить собственно синестетические словосочетания и явления, близкие к синестезии, однако не тождественные ей. | [
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283 | Практическая ценность диссертации состоит в том, что предложенный соискателем метод анализа лексических единиц и словосочетаний, содержащих сенсорный семантический компонент, может применяться в других исследованиях семантики сенсорной лексики. | [
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284 | Модели перевода лексических единиц, которые были сформированы в результате анализа переводных соответствий, потенциально полезны для исследований в области машинного перевода. | [
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285 | Полученные в работе выводы могут быть использованы в рамках дисциплин, связанных с семантикой, а также при создании курсов, посвящённых сенсорной лингвистике или языковым проявлениям синестезии. | [
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286 | Впервые для диагностики фемтосекундной филаментации реализован широкополосный акустический метод, обеспечивающий в каждом лазерном выстреле измерение поперечного распределения поглощенной плотности энергии с разрешением менее 100 мкм. | [
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287 | Показано, что устойчивые массивы филаментов, образованные отверстиями амплитудной маски при ее облучении слабосфокусированным либо коллимированным фемтосекундным импульсом, формируются, если пиковая мощность в каждом из пучков, образованных отверстиями, превышает критическую мощность самофокусировки в 2-3 раза, и если фокусное расстояние линзы больше длины самофокусировки каждого из пучков, либо расстояния первой зоны Френеля для отверстия амплитудной маски. | [
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288 | Предложена и апробирована экспериментальная схема, обеспечивающая увеличение выхода ТГц излучения из одноцветного множественного филамента более чем на два порядка. | [
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289 | Экспериментально показано, что оптимальный режим генерации ТГц излучения достигается при слабой фокусировке лазерного импульса и при условии, что длина приложения электростатического поля примерно равна длине плазменного канала филамента. | [
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290 | Исследования по улучшению структуры и свойств алюминиевых сплавов для изделий перспективной ракетно-космической техники совершенствованием режимов технологических воздействий в процессах получения отливок, сварки, деформирования и термической обработки | [
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291 | Актуальность темы исследования. | [
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292 | Расположение региона, уровень его экономического развития, характер хозяйственных связей на протяжении столетий являлись ключевыми факторами, принимаемыми во внимание при формировании инфраструктуры. | [
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293 | Удачное географическое положение, историческое наследие и экономические связи с Россией способствовали развитию в странах Балтии национальных транспортно-логистических комплексов. | [
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294 | Транспортная инфраструктура в течение длительного времени была в большей степени ориентирована на обслуживание транзитных грузов. | [
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295 | Однако изменившаяся геополитическая ситуация требовала внесения определенных коррективов. | [
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296 | Выбранный странами политический вектор в итоге лишил или существенно сократил интенсивность транзитных товарных потоков. | [
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297 | В осложнившейся обстановке финансовой и технической основой формирования транспортной инфраструктуры стран Балтии стала региональная экономическая политика Европейского союза. | [
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298 | Научная новизна. | [
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299 | В представленной диссертации впервые выявлены и обобщены особенности исторического развития портовой инфраструктуры стран Балтии; дана характеристика современного состояния транспортной инфраструктуры стран Балтии. | [
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