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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
null | null | Negative | MESH:D009394 | null | null | Alport's syndrome | 60498 | null | IgAN | null | 28,197,459 | The most common diagnostic entity was IgMN (46.6%) followed by IgAN (30%) along with few cases of class II LN, C1qN, minimal change disease (MCD), Alport's syndrome, focal segmental glomerulosclerosis (FSGS), thin basement membrane disease (TBMD), and fibrillary glomerulonephritis. | null | null | null |
1 | 0 | Biomarker | C0011849 | Diabetes Mellitus | group | diabetes | 23411 | SIRT1 | Sirt1 | CTD_human | 24,894,401 | Thus, in diabetes, increase in oxidative stress inhibits Sirt1 and p65 is hyperacetylated, increasing the binding of p65 at MMP-9 promoter. | 0.206044 | Thus, in <span class="disease" id="24894401-12-9-17">diabetes</span>, increase in oxidative stress inhibits <span class="gene" id="24894401-12-57-62">Sirt1</span> and p65 is hyperacetylated, increasing the binding of p65 at MMP-9 promoter. | CTD_human |
null | null | Negative | MESH:D057180 | null | null | FTD | 14824 | null | GRN | null | 28,093,491 | Aberrant microglial function has also been implicated in FTD caused by GRN, MAPT and C9orf72 mutations. | null | null | null |
null | null | Negative | MESH:D017827 | null | null | wild-type | 11450 | null | adiponectin | null | 28,073,830 | To investigate the causal role of hypoadiponectinemia in GDM, adiponectin gene knockout (Adipoq-/- ) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. | null | null | null |
null | null | Negative | MESH:D002527 | null | null | RN | 8811 | null | GalR2 | null | 28,013,000 | Galanin receptor type 1 (GalR1)/type 2 (GalR2) antagonist M40, and a preferential GalR2 antagonist M871 were administered over 3days locally into either RN or LC by means of ALZET osmotic minipumps connected to locally implanted infusion cannulas. | null | null | null |
3 | 0 | Biomarker | C0017638 | Glioma | disease | gliomas | 4255 | MGMT | O6-methylguanine-DNA methyltransferase | CTD_human | 16,033,832 | Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas. | 0.262095 | Prognostic significance of <span class="gene" id="16033832-0-27-65">O6-methylguanine-DNA methyltransferase</span> determined by promoter hypermethylation and immunohistochemical expression in anaplastic <span class="disease" id="16033832-0-155-162">gliomas</span>. | CTD_human |
1 | 0 | Biomarker | C0020456 | Hyperglycemia | disease | Hyperglycemia | 4846 | NOS3 | endothelial nitric oxide synthase | CTD_human | 11,696,579 | Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. | 0.207063 | <span class="disease" id="11696579-0-0-13">Hyperglycemia</span> inhibits <span class="gene" id="11696579-0-23-56">endothelial nitric oxide synthase</span> activity by posttranslational modification at the Akt site. | CTD_human |
1 | 0 | Biomarker | C1510586 | Autism Spectrum Disorders | disease | ASD | 5101 | PCDH9 | PCDH9 | CTD_human | 18,252,227 | Notwithstanding complexities, our results further implicate the SHANK3-NLGN4-NRXN1 postsynaptic density genes and also identify novel loci at DPP6-DPP10-PCDH9 (synapse complex), ANKRD11, DPYD, PTCHD1, 15q24, among others, for a role in ASD susceptibility. | 0.200275 | Notwithstanding complexities, our results further implicate the SHANK3-NLGN4-NRXN1 postsynaptic density genes and also identify novel loci at DPP6-DPP10-<span class="gene" id="18252227-8-153-158">PCDH9</span> (synapse complex), ANKRD11, DPYD, PTCHD1, 15q24, among others, for a role in <span class="disease" id="18252227-8-236-239">ASD</span> susceptibility. | CTD_human |
null | null | Negative | MESH:D005910 | null | null | glioma | 574476 | null | miR-520c | null | 28,184,932 | However, the clinical significance of miR-520c and its biological function in glioma remain largely unknown. | null | null | null |
null | null | Negative | MESH:C535468 | null | null | copper nanowires | 717 | null | CO2 | null | 28,094,953 | Herein, we investigate the electrocatalytic activity of ultrathin (diameter 20 nm) 5-fold twinned copper nanowires (Cu NWs) for CO2 reduction. | null | null | null |
null | null | Negative | MESH:D009369 | null | null | tumor | 15977 | null | IFNb | null | 28,015,893 | IFNb-MSC doubled the survival of tumor-bearing mice (p=0.001) while SC injected IFNb was ineffective (p=0.021 vs p=0.4). | null | null | null |
4 | 0 | Biomarker | C0036457 | Scrapie | disease | Scrapie | 5621 | PRNP | prion protein | CTD_human | 18,717,736 | Scrapie infection stimulated Gpc-1 autoprocessing and the generated HS degradation products colocalized with intracellular aggregates of the disease-related scrapie prion protein isoform (PrP(Sc)). | 0.201374 | <span class="disease" id="18717736-6-0-7">Scrapie</span> infection stimulated Gpc-1 autoprocessing and the generated HS degradation products colocalized with intracellular aggregates of the disease-related scrapie <span class="gene" id="18717736-6-165-178">prion protein</span> isoform (PrP(Sc)). | CTD_human |
null | null | Negative | MESH:D009369 | null | null | tumor | 667435 | null | BT-20 | null | 28,015,256 | METHODS: HT-29, LS174T, Moser (human colonic tumor lines), MCA38 and MCA38cea (murine colonic tumor lines), BT-20 (human breast tumor line) were grown in culture. | null | null | null |
2 | 0 | Biomarker | C0036996 | Short Rib-Polydactyly Syndrome | disease | short-rib polydactyly syndrome | 4750 | NEK1 | NEK1 | CTD_human | 21,211,617 | NEK1 mutations cause short-rib polydactyly syndrome type majewski. | 0.200275 | <span class="gene" id="21211617-0-0-4">NEK1</span> mutations cause <span class="disease" id="21211617-0-21-51">short-rib polydactyly syndrome</span> type majewski. | CTD_human |
null | null | Negative | OMIM:188890 | null | null | CSE | 81631 | null | LC3B | null | 28,006,950 | In addition, GSNO augmentation inhibits protein misfolding as CSE-induced colocalization of ubiquitinated proteins and LC3B (in autophagy bodies) is significantly reduced by GSNO/N6022 treatment. | null | null | null |
1 | 0 | Biomarker | C3714756 | Intellectual Disability | group | intellectual disability | 1788 | DNMT3A | DNMT3A | CTD_human | 24,614,070 | Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability. | 0.200275 | Mutations in the DNA methyltransferase gene <span class="gene" id="24614070-0-44-50">DNMT3A</span> cause an overgrowth syndrome with <span class="disease" id="24614070-0-85-108">intellectual disability</span>. | CTD_human |
5 | 3 | Biomarker | C0004096 | Asthma | disease | asthma | 9173 | IL1RL1 | IL1RL1 | CTD_human | 19,198,610 | A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). | 0.225077 | A SNP at <span class="gene" id="19198610-5-9-15">IL1RL1</span> associated with <span class="disease" id="19198610-5-32-38">asthma</span> (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). | CTD_human |
6 | 0 | Biomarker | C0038358 | Gastric ulcer | disease | gastric ulcerations | 885 | CCK | CCK | CTD_human | 11,787,760 | Leptin, a product of ob gene controlling food intake, has recently been detected in the stomach and shown to be released by CCK and implicated in gastroprotection against various noxious agents but it is unknown whether centrally applied leptin influences ischemia-reperfusion (I/R)-induced gastric erosions that progress into deeper gastric ulcerations. | 0.2 | Leptin, a product of ob gene controlling food intake, has recently been detected in the stomach and shown to be released by <span class="gene" id="11787760-1-124-127">CCK</span> and implicated in gastroprotection against various noxious agents but it is unknown whether centrally applied leptin influences ischemia-reperfusion (I/R)-induced gastric erosions that progress into deeper <span class="disease" id="11787760-1-334-353">gastric ulcerations</span>. | CTD_human |
null | null | Negative | MESH:D003130 | null | null | WARs | 314322 | null | c-Fos | null | 28,188,855 | Data from inferior colliculus (IC) c-Fos immunohistochemistry and electrographic recordings were gathered for both the control Wistar group and WARs. | null | null | null |
null | null | Negative | MESH:D010146 | null | null | pain | 171056 | null | CX3CR1 | null | 28,028,627 | Neuron-microglia crosstalk, mediated by the purinergic P2X7 receptor (R)/fractalkine/CX3CR1 cascade in the spinal cord dorsal horn, plays a pivotal role in pain processing. | null | null | null |
null | null | Negative | MESH:D009422 | null | null | neuropathy | 28508 | null | DM2 | null | 28,138,246 | CONCLUSION: Our results indicate a complex association between neuropathy and SRBDs in DM1 and DM2. | null | null | null |
96 | 174 | Biomarker | C0019202 | Hepatolenticular Degeneration | disease | WD | 540 | ATP7B | ATP7B | CTD_human | 25,134,866 | OSIP108 increased not only viability of Cu-treated CHO cells transgenically expressing ATP7B and the common WD-causing mutant ATP7B(H1069Q), but also viability of Cu-treated human glioblastoma U87 cells. | 0.885769 | OSIP108 increased not only viability of Cu-treated CHO cells transgenically expressing <span class="gene" id="25134866-4-87-92">ATP7B</span> and the common <span class="disease" id="25134866-4-108-110">WD</span>-causing mutant <span class="gene" id="25134866-4-126-131">ATP7B</span>(H1069Q), but also viability of Cu-treated human glioblastoma U87 cells. | CTD_human;ORPHANET;UNIPROT |
4 | 29 | Biomarker | C1970431 | PITT-HOPKINS SYNDROME | disease | Pitt-Hopkins syndrome | 6925 | TCF4 | TCF4 | CTD_human | 17,436,254 | Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction. | 0.607418 | Mutations in <span class="gene" id="17436254-0-13-17">TCF4</span>, encoding a class I basic helix-loop-helix transcription factor, are responsible for <span class="disease" id="17436254-0-103-124">Pitt-Hopkins syndrome</span>, a severe epileptic encephalopathy associated with autonomic dysfunction. | CTD_human;ORPHANET;UNIPROT |
null | null | Negative | MESH:D014947 | null | null | injury of mitochondria | 574045 | null | HNP1 | null | 28,022,941 | Our study also suggests that the damage on cell membranes and injury of mitochondria mediated by HNP1 may provide a new strategy for reverse of chemotherapy resistance. | null | null | null |
1 | 0 | Biomarker | C1510586 | Autism Spectrum Disorders | disease | ASD | 29123 | ANKRD11 | ANKRD11 | CTD_human | 18,252,227 | Notwithstanding complexities, our results further implicate the SHANK3-NLGN4-NRXN1 postsynaptic density genes and also identify novel loci at DPP6-DPP10-PCDH9 (synapse complex), ANKRD11, DPYD, PTCHD1, 15q24, among others, for a role in ASD susceptibility. | 0.200824 | Notwithstanding complexities, our results further implicate the SHANK3-NLGN4-NRXN1 postsynaptic density genes and also identify novel loci at DPP6-DPP10-PCDH9 (synapse complex), <span class="gene" id="18252227-8-178-185">ANKRD11</span>, DPYD, PTCHD1, 15q24, among others, for a role in <span class="disease" id="18252227-8-236-239">ASD</span> susceptibility. | CTD_human |
1 | 0 | Biomarker | C0036572 | Seizures | phenotype | EXP1 | 7779 | SLC30A1 | ZnT-1 | CTD_human | 23,266,720 | Among the total twelve genes, six genes were strongly up- (MT-3, ACAT1, clusterin and ApoE) or down- (ZnT-1 and PRG-3) regulated by developmental seizures (EXP1) compared with that in the CONT1. | 0.2 | Among the total twelve genes, six genes were strongly up- (MT-3, ACAT1, clusterin and ApoE) or down- (<span class="gene" id="23266720-8-102-107">ZnT-1</span> and PRG-3) regulated by developmental <span class="disease" id="23266720-8-146-154">seizures</span> (<span class="disease" id="23266720-8-156-160">EXP1</span>) compared with that in the CONT1. | CTD_human |
null | null | Negative | MESH:D003110 | null | null | colon cancer | 338399 | null | PS 1 | null | 28,016,662 | RESULTS: Two patients (pts) (PS 1; age:72 and 74) with measurable liver metastasis (colon cancer), non measurable but symptomatic bone metastasis (prostate cancer), and elevated baseline PSA values (12.5 and 255 ng/ml) were evaluable for toxicity and response. | null | null | null |
20 | 0 | Therapeutic | C0037769 | West Syndrome | disease | west syndrome | 5443 | POMC | ACTH | CTD_human | 19,039,989 | [Case of west syndrome associated with transient marked sinus dysfunction during ACTH therapy]. | 0.203022 | [Case of <span class="disease" id="19039989-0-9-22">west syndrome</span> associated with transient marked sinus dysfunction during <span class="gene" id="19039989-0-81-85">ACTH</span> therapy]. | CTD_human |
2 | 1 | Biomarker | C2931788 | Atypical Hemolytic Uremic Syndrome | disease | HUS | 3075 | CFH | FH | CTD_human | 14,978,182 | Four children with homozygous or heterozygous FH deficiency and HUS underwent renal transplantation, which was successful in three but failed as a result of recurrence of HUS in one patient. | 0.315309 | Four children with homozygous or heterozygous <span class="gene" id="14978182-5-46-48">FH</span> deficiency and <span class="disease" id="14978182-5-64-67">HUS</span> underwent renal transplantation, which was successful in three but failed as a result of recurrence of <span class="disease" id="14978182-5-171-174">HUS</span> in one patient. | CTD_human |
1 | 0 | Biomarker | C0004096 | Asthma | disease | asthma | 6347 | CCL2 | MCP-1 | CTD_human | 19,373,627 | These findings suggest a possible role for MCP-1 in the pathogenesis of asthma and a potential role for its use in anti-asthma treatment in the future. | 0.214782 | These findings suggest a possible role for <span class="gene" id="19373627-10-43-48">MCP-1</span> in the pathogenesis of <span class="disease" id="19373627-10-72-78">asthma</span> and a potential role for its use in anti-<span class="disease" id="19373627-10-120-126">asthma</span> treatment in the future. | CTD_human |
1 | 0 | Biomarker | C0149521 | Pancreatitis, Chronic | disease | chronic pancreatitis | 1357 | CPA1 | CPA1 | CTD_human | 23,955,596 | Variants in CPA1 are strongly associated with early onset chronic pancreatitis. | 0.200549 | Variants in <span class="gene" id="23955596-0-12-16">CPA1</span> are strongly associated with early onset <span class="disease" id="23955596-0-58-78">chronic pancreatitis</span>. | CTD_human |
2 | 0 | Biomarker | C1319853 | Asthma, Aspirin-Induced | disease | AIA | 5743 | PTGS2 | COX-2 | CTD_human | 16,502,481 | Several single nucleotide polymorphisms (SNPs) in the promoters of EP2, TBX21, COX-2, Fc epsilon RIbeta, and TBXA2R were associated with AIA, while an Fc epsilon RIalpha promoter polymorphism was associated with AIU. | 0.200275 | Several single nucleotide polymorphisms (SNPs) in the promoters of EP2, TBX21, <span class="gene" id="16502481-6-79-84">COX-2</span>, Fc epsilon RIbeta, and TBXA2R were associated with <span class="disease" id="16502481-6-137-140">AIA</span>, while an Fc epsilon RIalpha promoter polymorphism was associated with AIU. | CTD_human |
1 | 3 | Biomarker | C0206754 | Neuroendocrine Tumors | group | neuroendocrine tumors | 1027 | CDKN1B | CDKN1B | CTD_human | 24,185,511 | Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. | 0.203557 | Somatic mutation of <span class="gene" id="24185511-0-20-26">CDKN1B</span> in small intestine <span class="disease" id="24185511-0-46-67">neuroendocrine tumors</span>. | CTD_human |
1 | 0 | Biomarker | C0011881 | Diabetic Nephropathy | disease | diabetic nephropathy | 10628 | TXNIP | thioredoxin interacting protein | CTD_human | 17,582,205 | A possible role of thioredoxin interacting protein in the pathogenesis of streptozotocin-induced diabetic nephropathy. | 0.201374 | A possible role of <span class="gene" id="17582205-0-19-50">thioredoxin interacting protein</span> in the pathogenesis of streptozotocin-induced <span class="disease" id="17582205-0-97-117">diabetic nephropathy</span>. | CTD_human |
null | null | Negative | MESH:D055370 | null | null | lung injury | 15568 | null | ELAVL-1 | null | 28,196,122 | Utilizing ventilator-induced lung injury or intra-tracheal installation of hydrochloric acid to induce ARDS in mice, we observed increased mRNA and protein expression of ELAVL-1/HuR and GSK3b. | null | null | null |
null | null | Negative | OMIM:135300 | null | null | HGF | 4233 | null | c-Met | null | 28,023,034 | Dysregulation of the HGF/c-Met pathway is a rational therapeutic target in AGEC. | null | null | null |
null | null | Negative | MESH:D054221 | null | null | MDS | 84868 | null | T-cell immunoglobulin mucin-3 | null | 28,159,737 | Overexpression of several markers such as interleukin-1 (IL-1) receptor accessory protein (IL1RAP), CD99, T-cell immunoglobulin mucin-3, and CD123 have begun to differentiate MDS HSPCs from healthy counterparts. | null | null | null |
null | null | Negative | MESH:D053632 | null | null | SCID | 19225 | null | COX-2 | null | 28,015,089 | METHODS: Human lung adenocarcinoma cells expressing EGFR and COX-2 (ATCC-CRL5908) were implanted in the left upper lobe of SCID mice (2*10(6) cells/25uL). | null | null | null |
1 | 0 | Biomarker | C0020757 | Ichthyoses | disease | ichthyosis | 6832 | SUPV3L1 | Supv3L1 | CTD_human | 19,145,458 | Conditional ablation of Supv3L1 in keratinocytes confirmed atrophic changes in the skin and ichthyosis-like changes. | 0.200275 | Conditional ablation of <span class="gene" id="19145458-9-24-31">Supv3L1</span> in keratinocytes confirmed atrophic changes in the skin and <span class="disease" id="19145458-9-92-102">ichthyosis</span>-like changes. | CTD_human |
null | null | Negative | MESH:D009369 | null | null | cancer | 9173;292 | null | T1/T2 | null | 28,141,132 | METHODS: Using the National Cancer Database (NCDB), we evaluated women who underwent a mastectomy or BCT for T1/T2, any N breast cancer between 1998 and 2011. | null | null | null |
2 | 0 | Biomarker | C0028754 | Obesity | disease | obesity | 5443 | POMC | POMC | CTD_human | 16,289,378 | Decrease in brain POMC mRNA expression and onset of obesity in guinea pigs exposed to 2-chloroethyl ethyl sulfide, a mustard analogue. | 0.528115 | Decrease in brain <span class="gene" id="16289378-0-18-22">POMC</span> mRNA expression and onset of <span class="disease" id="16289378-0-52-59">obesity</span> in guinea pigs exposed to 2-chloroethyl ethyl sulfide, a mustard analogue. | CTD_human;HPO |
null | null | Negative | MESH:D009369 | null | null | inha/Tag adrenal tumors | 14683 | null | Gnas | null | 28,131,743 | Besides earlier reported Gata4 and Lhcgr, we found up-regulated Esr1, Prlr-rs1, and down-regulated Grb10, Mmp24, Sgcd, Rerg, Gnas, Nfatc2, Gnrhr, Igf2 in inha/Tag adrenal tumors. | null | null | null |
null | null | Negative | MESH:C564286 | null | null | zinc deficiency | 1432 | null | p38 MAPK | null | 28,158,919 | Administration of SB203580 to HFD mice or specific siRNA in palmitate-treated cardiomyocytes eliminated the HFD and zinc deficiency activation of p38 MAPK, but did not significantly impact the expression of BCL10 and CARD9. | null | null | null |
1 | 0 | Biomarker | C0279626 | Squamous cell carcinoma of esophagus | disease | ESCC | 3872 | KRT17 | KRT17 | CTD_human | 21,517,111 | Among these identified proteins, 33 proteins including keratin 17 (KRT17), biliverdin reductase B (BLVRB), proteasome activator subunit 1 (PSME1), manganese superoxide dismutase (MnSOD), high-mobility group box-1(HMGB1), heat shock protein 70 (HSP70), peroxiredoxin (PRDX1), keratin 13 (KRT13), and so on were overexpressed, and 14 proteins including cystatin B (CSTB), tropomyosin 2 (TPM2), annexin 1 (ANX1), transgelin (TAGLN), keratin 19 (KRT19), stratifin (SFN), and so on were down-expressed in ESCC. | 0.2 | Among these identified proteins, 33 proteins including <span class="gene" id="21517111-5-55-65">keratin 17</span> (<span class="gene" id="21517111-5-67-72">KRT17</span>), biliverdin reductase B (BLVRB), proteasome activator subunit 1 (PSME1), manganese superoxide dismutase (MnSOD), high-mobility group box-1(HMGB1), heat shock protein 70 (HSP70), peroxiredoxin (PRDX1), keratin 13 (KRT13), and so on were overexpressed, and 14 proteins including cystatin B (CSTB), tropomyosin 2 (TPM2), annexin 1 (ANX1), transgelin (TAGLN), keratin 19 (KRT19), stratifin (SFN), and so on were down-expressed in <span class="disease" id="21517111-5-500-504">ESCC</span>. | CTD_human |
null | null | Negative | MESH:D007759 | null | null | inner plexiform layer | 64396 | null | GCL | null | 28,135,360 | Optical coherence tomography was used to characterize the association between pupillary response characteristics and alterations in retinal architecture, specifically, the thickness of the retinal ganglion cell layer and inner plexiform layer (GCL + IPL). | null | null | null |
6 | 0 | Therapeutic | C0038358 | Gastric ulcer | disease | gastric ulcer | 3952 | LEP | leptin | CTD_human | 16,015,682 | Mechanisms of action of leptin in preventing gastric ulcer. | 0.2 | Mechanisms of action of <span class="gene" id="16015682-0-24-30">leptin</span> in preventing <span class="disease" id="16015682-0-45-58">gastric ulcer</span>. | CTD_human |
null | null | Negative | MESH:C563256 | null | null | FCD type Ia | 56666 | null | Panx2 | null | 28,036,289 | In this study, we investigated the expression of Panx1 and Panx2 in surgical samples from patients with FCD type Ia (FCDIa), type IIa (FCDIIa), and type IIb (FCDIIb) and in age-matched autopsy control samples. | null | null | null |
null | null | Negative | MESH:D050197 | null | null | atherosclerosis | 16835 | null | low-density lipoprotein receptor | null | 28,062,509 | To induce atherosclerosis, mice were crossed onto the low-density lipoprotein receptor (Ldlr)-deficient background. | null | null | null |
null | null | Negative | MESH:D018205 | null | null | adiposity | 11814 | null | APOC3 | null | 28,115,523 | APOC3 neither exacerbated diet-induced adiposity nor aggravated the degree of steatosis in high fructose or high fat-fed APOC3-transgenic mice. | null | null | null |
28 | 0 | Biomarker | C0007131 | Non-Small Cell Lung Carcinoma | disease | non-small-cell lung cancer | 238 | ALK | ALK | CTD_human | 21,933,749 | Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. | 0.28 | Effect of crizotinib on overall survival in patients with advanced <span class="disease" id="21933749-0-67-93">non-small-cell lung cancer</span> harbouring <span class="gene" id="21933749-0-105-108">ALK</span> gene rearrangement: a retrospective analysis. | CTD_human |
null | null | Negative | MESH:D001749 | null | null | bladder cancer | 574058 | null | PD-L1 | null | 28,214,651 | Several checkpoint targets (programmed death ligand-1 [PD-L1] programmed cell death protien-1 [PD-1], and cytotoxic T-lymphocyte associated protein 4 [CTLA4]) have received the most attention in the treatment of bladder cancer, and have inhibitor agents either approved or in late-stage development. | null | null | null |
1 | 8 | Biomarker | C1843807 | Basal ganglia disease, biotin-responsive | disease | Biotin-responsive basal ganglia disease | 80704 | SLC19A3 | SLC19A3 | CTD_human | 15,871,139 | Biotin-responsive basal ganglia disease maps to 2q36.3 and is due to mutations in SLC19A3. | 0.602747 | <span class="disease" id="15871139-0-0-39">Biotin-responsive basal ganglia disease</span> maps to 2q36.3 and is due to mutations in <span class="gene" id="15871139-0-82-89">SLC19A3</span>. | CTD_human;ORPHANET;UNIPROT |
null | null | Negative | MESH:D015456 | null | null | B-cell acute lymphoblastic leukemia | 56371 | null | Fzr1 | null | 28,143,883 | In an Fzr1 gene-trap mouse model of B-cell acute lymphoblastic leukemia (B-ALL), mice with Fzr1-deficient B-ALL survived longer than those with Fzr1-intact disease, and sensitivity of Fzr1-deficient B-ALL cells to DNA damage appeared increased. | null | null | null |
1 | 0 | Biomarker | C0022665 | Kidney Neoplasm | disease | kidney tumor | 1978 | EIF4EBP1 | 4EBP1 | CTD_human | 21,813,464 | The data indicate that Raf-1/MEK/ERK participates in crosstalk with 4EBP1, which represents a novel pathway interaction leading to increased protein synthesis, cell growth, and kidney tumor formation. | 0.200275 | The data indicate that Raf-1/MEK/ERK participates in crosstalk with <span class="gene" id="21813464-10-68-73">4EBP1</span>, which represents a novel pathway interaction leading to increased protein synthesis, cell growth, and <span class="disease" id="21813464-10-177-189">kidney tumor</span> formation. | CTD_human |
null | null | Negative | MESH:D019446 | null | null | endotoxemia | 16150 | null | IKKb | null | 28,145,460 | CGA-JK3 consequently interrupted IKKb-inducible NF-kB activation and NF-kB-regulated expression of TNF-a, IL-1a or HMGB-1 gene, thereby improving TLRs-associated redundant inflammatory responses in endotoxemia, polymicrobial sepsis and ALF. | null | null | null |
2 | 1 | Biomarker | C0009324 | Ulcerative Colitis | disease | ulcerative colitis | 6774 | STAT3 | STAT3 | CTD_human | 18,438,405 | Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. | 0.214899 | Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and <span class="gene" id="18438405-2-151-156">STAT3</span> were associated only with <span class="disease" id="18438405-2-183-201">ulcerative colitis</span> in our sample collection. | CTD_human |
null | null | Negative | MESH:D001862 | null | null | bone resorption | 17700 | null | GDF8 | null | 28,074,479 | Intraperitoneal injection of recombinant GDF8 repressed bone formation and accelerated bone resorption in mice. | null | null | null |
null | null | Negative | MESH:D007249 | null | null | inflammation | 397422 | null | CCL2 | null | 28,013,313 | RESULTS: Only severe NEC cases (score of 5-6) were associated with the upregulation of genes involved in inflammation (CCL2, CCL3, CD14, CD163, CXCL8, HP, IL1B, IL1RN, IL6,IL10, NFKBIA, PTGS2 and TNFAIP3) compared to pigs that appeared healthy (score of 1-2) or showed mild NEC (score of 3-4). | null | null | null |
null | null | Negative | MESH:D015430 | null | null | weight gain | 12491 | null | fat | null | 28,197,827 | Phloretin treatment significantly blocks high-fat diet-induced weight gain but did not induce weight loss in obese animals. | null | null | null |
null | null | Negative | MESH:D018805 | null | null | sepsis | 21926 | null | TNF-a | null | 28,145,460 | CGA-JK3 consequently interrupted IKKb-inducible NF-kB activation and NF-kB-regulated expression of TNF-a, IL-1a or HMGB-1 gene, thereby improving TLRs-associated redundant inflammatory responses in endotoxemia, polymicrobial sepsis and ALF. | null | null | null |
null | null | Negative | MESH:D009133 | null | null | muscle atrophy | 81736 | null | NF-kB | null | 28,009,536 | The mRNA expression of NF-kB, muscle atrophy F-box (MAFbx), and muscle ring finger 1 (MuRF1) was upregulated by the LPS challenge in gastrocnemius muscles, but was downregulated by Leu supplementation. | null | null | null |
null | null | Negative | MESH:C536528 | null | null | LPS | 9933 | null | PUFA | null | 28,125,622 | Subjects received n-3 PUFA (n = 8; 3600mg/day EPA/DHA) or matched placebo (n = 6) for 6-8 weeks, before completing an endotoxin challenge (LPS 0.6 ng/kg). | null | null | null |
1 | 0 | Biomarker | C0025202 | melanoma | disease | melanoma | 2776 | GNAQ | GNAQ | CTD_human | 23,432,625 | The mutations, such as those in NRAS, BRAF, GNAQ and GNA11, promote the growth of melanoma cells in most part through the mitogen-activated protein kinase (MAPK) pathway. | 0.217581 | The mutations, such as those in NRAS, BRAF, <span class="gene" id="23432625-2-44-48">GNAQ</span> and GNA11, promote the growth of <span class="disease" id="23432625-2-82-90">melanoma</span> cells in most part through the mitogen-activated protein kinase (MAPK) pathway. | CTD_human |
2 | 7 | Biomarker | C0266313 | Allanson Pantzar McLeod syndrome | disease | renal tubular dysgenesis | 1636 | ACE | angiotensin converting enzyme | CTD_human | 16,116,425 | We studied 11 individuals with renal tubular dysgenesis, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, angiotensin converting enzyme or angiotensin II receptor type 1. | 0.601099 | We studied 11 individuals with <span class="disease" id="16116425-3-31-55">renal tubular dysgenesis</span>, belonging to nine families, and found that they had homozygous or compound heterozygous mutations in the genes encoding renin, angiotensinogen, <span class="gene" id="16116425-3-201-230">angiotensin converting enzyme</span> or angiotensin II receptor type 1. | CTD_human;HPO;ORPHANET |
null | null | Negative | MESH:D000860 | null | null | Hypoxia | 15251 | null | HIF-1a | null | 28,039,264 | Hypoxia-inducible factor-1a (HIF-1a) induces the expression of proteins associated with stemness and is highly upregulated in TNBC. | null | null | null |
1 | 0 | Biomarker | C0023264 | Leigh Disease | disease | Leigh syndrome | 4722 | NDUFS3 | NDUFS3 | CTD_human | 14,729,820 | Mutant NDUFS3 subunit of mitochondrial complex I causes Leigh syndrome. | 0.400549 | Mutant <span class="gene" id="14729820-0-7-13">NDUFS3</span> subunit of mitochondrial complex I causes <span class="disease" id="14729820-0-56-70">Leigh syndrome</span>. | CTD_human;ORPHANET |
null | null | Negative | MESH:D015775 | null | null | endoplasmic reticulum stress | 14824 | null | progranulin | null | 28,143,512 | METHODS: In the present study, progranulin was administered to 3T3-L1 adipocytes and C57BL/6 J mice with/without specific inhibitors of oxidative stress and endoplasmic reticulum stress, and metabolic parameters, oxidative stress, endoplasmic reticulum stress and autophagy markers were assessed. | null | null | null |
96 | 174 | Biomarker | C0019202 | Hepatolenticular Degeneration | disease | WD | 540 | ATP7B | ATP7B | CTD_human | 11,405,812 | After cloning of ATP7B, the spectrum of mutations and their clinical consequences have been investigated in patients with WD in different ethnic populations. | 0.885769 | After cloning of <span class="gene" id="11405812-2-17-22">ATP7B</span>, the spectrum of mutations and their clinical consequences have been investigated in patients with <span class="disease" id="11405812-2-122-124">WD</span> in different ethnic populations. | CTD_human;ORPHANET;UNIPROT |
null | null | Negative | OMIM:168600 | null | null | PD | 3183;717 | null | C1 and 2 | null | 28,022,973 | PBMCs will be collected prior to and during C1 and 2 for PD and PK analyses. | null | null | null |
1 | 4 | Biomarker | C0017612 | Glaucoma, Open-Angle | disease | open angle glaucoma | 100048912 | CDKN2B-AS1 | CDKN2B-AS1 | CTD_human | 21,532,571 | Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1. | 0.200824 | Genome-wide association study identifies susceptibility loci for <span class="disease" id="21532571-0-65-84">open angle glaucoma</span> at TMCO1 and <span class="gene" id="21532571-0-98-108">CDKN2B-AS1</span>. | CTD_human |
1 | 0 | Biomarker | C0004352 | Autistic Disorder | disease | autism | 2890 | GRIA1 | AMPA 1 | CTD_human | 11,706,102 | The mRNA levels of several genes were significantly increased in autism, including excitatory amino acid transporter 1 and glutamate receptor AMPA 1, two members of the glutamate system. | 0.2 | The mRNA levels of several genes were significantly increased in <span class="disease" id="11706102-7-65-71">autism</span>, including excitatory amino acid transporter 1 and glutamate receptor <span class="gene" id="11706102-7-142-148">AMPA 1</span>, two members of the glutamate system. | CTD_human |
3 | 0 | Biomarker | C0003123 | Anorexia | disease | anorectic | 4852 | NPY | NPY | CTD_human | 16,084,549 | To determine if c-fos or c-jun was involved in the anorectic response of AMPH, infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats, and the results showed that c-fos or c-jun knockdown could block this anorectic response and restore NPY mRNA level. | 0.281923 | To determine if c-fos or c-jun was involved in the <span class="disease" id="16084549-5-51-60">anorectic</span> response of AMPH, infusions of antisense oligonucleotide into the brain were performed at 1 h before daily AMPH treatment in freely moving rats, and the results showed that c-fos or c-jun knockdown could block this <span class="disease" id="16084549-5-276-285">anorectic</span> response and restore <span class="gene" id="16084549-5-307-310">NPY</span> mRNA level. | CTD_human |
1 | 0 | Biomarker | C0030567 | Parkinson Disease | disease | PD | 4803 | NGF | nerve growth factor | CTD_human | 19,276,553 | IGF-I and IGF-II resistance was present in DLB but not PD frontal cortex, and associated with reduced expression of Hu, nerve growth factor, and Trk neurotrophin receptors, and increased levels of glial fibrillary acidic protein, alpha-synuclein, dopamine-beta-hydroxylase, 4-hydroxy-2-nonenal (HNE), and ubiquitin immunoreactivity. | 0.200824 | IGF-I and IGF-II resistance was present in DLB but not <span class="disease" id="19276553-4-55-57">PD</span> frontal cortex, and associated with reduced expression of Hu, <span class="gene" id="19276553-4-120-139">nerve growth factor</span>, and Trk neurotrophin receptors, and increased levels of glial fibrillary acidic protein, alpha-synuclein, dopamine-beta-hydroxylase, 4-hydroxy-2-nonenal (HNE), and ubiquitin immunoreactivity. | CTD_human |
1 | 0 | Biomarker | C0023467 | Leukemia, Myelocytic, Acute | disease | AML | 1978 | EIF4EBP1 | 4E-BP1 | CTD_human | 19,458,359 | We identified the Pim-2 serine/threonine kinase as mainly responsible for 4E-BP1 phosphorylation on the S(65) residue and subsequent translation control in AML. | 0.201923 | We identified the Pim-2 serine/threonine kinase as mainly responsible for <span class="gene" id="19458359-7-74-80">4E-BP1</span> phosphorylation on the S(65) residue and subsequent translation control in <span class="disease" id="19458359-7-156-159">AML</span>. | CTD_human |
1 | 0 | Biomarker | C1458155 | Mammary Neoplasms | group | breast tumours | 1364 | CLDN4 | claudin-4 | CTD_human | 19,142,967 | This relationship between increased claudin-4 expression and adverse outcome was validated at the mRNA level in a DNA microarray dataset of 295 breast tumours. | 0.200549 | This relationship between increased <span class="gene" id="19142967-9-36-45">claudin-4</span> expression and adverse outcome was validated at the mRNA level in a DNA microarray dataset of 295 <span class="disease" id="19142967-9-144-158">breast tumours</span>. | CTD_human |
null | null | Negative | MESH:D009103 | null | null | MS | 6697 | null | SPR | null | 28,132,898 | After luciferase reporter assays revealed that the G-quadruplex could inhibit the activity of the FGFR2 promoter, MS and SPR showed binding affinity and selectivity of the ligand. | null | null | null |
1 | 1 | Biomarker | C0030305 | Pancreatitis | disease | pancreatitis | 5644 | PRSS1 | PRSS1 | CTD_human | 23,143,602 | Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. | 0.494169 | Common genetic variants in the CLDN2 and <span class="gene" id="23143602-0-41-46">PRSS1</span>-PRSS2 loci alter risk for alcohol-related and sporadic <span class="disease" id="23143602-0-102-114">pancreatitis</span>. | CTD_human;HPO |
24 | 0 | Biomarker | C0002736 | Amyotrophic Lateral Sclerosis | disease | amyotrophic lateral sclerosis | 6647 | SOD1 | SOD1 | CTD_human | 11,590,119 | Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic Caenorhabditis elegans. | 0.798512 | Oxidative stress causes abnormal accumulation of familial <span class="disease" id="11590119-0-58-87">amyotrophic lateral sclerosis</span>-related mutant <span class="gene" id="11590119-0-103-107">SOD1</span> in transgenic Caenorhabditis elegans. | CTD_human;HPO;ORPHANET |
7 | 0 | Biomarker | C0011581 | Depressive disorder | disease | depression | 4852 | NPY | NPY | CTD_human | 17,572,454 | The data support our hypothesis that the NPY system dysregulation constitutes one of the biological underpinnings of depression and that one common mechanism of action of antidepressive treatment modalities may be effects on NPY and its receptors. | 0.483571 | The data support our hypothesis that the <span class="gene" id="17572454-9-41-44">NPY</span> system dysregulation constitutes one of the biological underpinnings of <span class="disease" id="17572454-9-117-127">depression</span> and that one common mechanism of action of antidepressive treatment modalities may be effects on <span class="gene" id="17572454-9-225-228">NPY</span> and its receptors. | CTD_human;PSYGENET |
2 | 0 | Biomarker | C2239176 | Liver carcinoma | disease | hepatocellular carcinomas | 598 | BCL2L1 | bcl-xs | CTD_human | 11,509,945 | To examine the effect of the bcl-xs gene on the sequence from hepatic precancerous lesions, foci and neoplastic nodules, to hepatocellular carcinomas, Sprague-Dawley rats were given water containing 175 mg/l N-nitrosomorpholine (NNM) for 8 weeks. | 0.213679 | To examine the effect of the <span class="gene" id="11509945-1-29-35">bcl-xs</span> gene on the sequence from hepatic precancerous lesions, foci and neoplastic nodules, to <span class="disease" id="11509945-1-124-149">hepatocellular carcinomas</span>, Sprague-Dawley rats were given water containing 175 mg/l N-nitrosomorpholine (NNM) for 8 weeks. | CTD_human |
4 | 0 | Biomarker | C0030297 | Pancreatic Neoplasm | disease | pancreatic tumor | 5743 | PTGS2 | COX-2 | CTD_human | 15,705,899 | These findings imply that assessing the COX-2 profile of the pancreatic tumor is mandatory before initiating therapy with a selective COX-2 inhibitor. | 0.214112 | These findings imply that assessing the <span class="gene" id="15705899-14-40-45">COX-2</span> profile of the <span class="disease" id="15705899-14-61-77">pancreatic tumor</span> is mandatory before initiating therapy with a selective <span class="gene" id="15705899-14-134-139">COX-2</span> inhibitor. | CTD_human |
1 | 0 | Biomarker | C1263846 | Attention deficit hyperactivity disorder | disease | ADHD | 1312 | COMT | COMT | CTD_human | 10,490,706 | Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype. | 0.457338 | Haplotype relative risk study of <span class="gene" id="10490706-0-33-61">catechol-O-methyltransferase</span> (<span class="gene" id="10490706-0-63-67">COMT</span>) and <span class="disease" id="10490706-0-73-113">attention deficit hyperactivity disorder</span> (<span class="disease" id="10490706-0-115-119">ADHD</span>): association of the high-enzyme activity Val allele with <span class="disease" id="10490706-0-178-182">ADHD</span> impulsive-hyperactive phenotype. | CTD_human;HPO |
null | null | Negative | MESH:D012163 | null | null | bracket detachment | 717 | null | CO2 | null | 28,140,147 | All polycrystalline brackets debonded with the CO2 laser resulted in a complete bracket detachment without bracket failure. | null | null | null |
1 | 0 | Biomarker | C0004153 | Atherosclerosis | disease | atherosclerosis | 196 | AHR | aryl hydrocarbon receptor | CTD_human | 22,228,805 | Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. | 0.200824 | Inherent and benzo[a]pyrene-induced differential <span class="gene" id="22228805-0-49-74">aryl hydrocarbon receptor</span> signaling greatly affects life span, <span class="disease" id="22228805-0-112-127">atherosclerosis</span>, cardiac gene expression, and body and heart growth in mice. | CTD_human |
1 | 0 | Biomarker | C0265202 | Seckel syndrome | disease | Seckel syndrome | 5116 | PCNT | pericentrin | CTD_human | 18,157,127 | Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. | 0.401374 | Mutations in <span class="gene" id="18157127-0-13-24">pericentrin</span> cause <span class="disease" id="18157127-0-31-46">Seckel syndrome</span> with defective ATR-dependent DNA damage signaling. | CTD_human;ORPHANET |
1 | 0 | Biomarker | C0020538 | Hypertensive disease | group | hypertension | 2796 | GNRH1 | LHRH | CTD_human | 6,350,720 | In addition, intraventricular administration of TRH, LHRH or LH caused tachycardia, hypertension and a reduction in the epinephrine-induced reflex bradycardia. | 0.2 | In addition, intraventricular administration of TRH, <span class="gene" id="6350720-5-53-57">LHRH</span> or LH caused tachycardia, <span class="disease" id="6350720-5-84-96">hypertension</span> and a reduction in the epinephrine-induced reflex bradycardia. | CTD_human |
35 | 84 | Biomarker | C0022716 | Menkes Kinky Hair Syndrome | disease | MD | 538 | ATP7A | ATP7A | CTD_human | 22,728,746 | Menkes disease (MD) is a disorder of copper transport caused by ATP7A mutations. | 0.727934 | <span class="disease" id="22728746-1-0-14">Menkes disease</span> (<span class="disease" id="22728746-1-16-18">MD</span>) is a disorder of copper transport caused by <span class="gene" id="22728746-1-64-69">ATP7A</span> mutations. | CTD_human;ORPHANET;UNIPROT |
null | null | Negative | MESH:D009223 | null | null | DM2 | 28509 | null | DM1 | null | 28,210,870 | METHODS: Three hundred and forty-five people with diabetes mellitus type 2 (DM2, n = 336, 229 without and 107 with insulin therapy) and type 1 (DM1, n = 9) were interviewed with the PAID questionnaire in the period from 1 October 2015 to 31 December 2015 in a general practice. | null | null | null |
null | null | Negative | MESH:D010024 | null | null | postmenopausal osteoporosis | 21926 | null | TNF-a | null | 28,002,602 | Furthermore, APS also markedly reduced osteocalcin and TNF-a concentration in OVX-induced postmenopausal osteoporosis mice model. | null | null | null |
35 | 84 | Biomarker | C0022716 | Menkes Kinky Hair Syndrome | disease | Menkes disease | 538 | ATP7A | ATP7A | CTD_human | 21,667,063 | The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression. | 0.727934 | The copper-transporting capacity of <span class="gene" id="21667063-0-36-41">ATP7A</span> mutants associated with <span class="disease" id="21667063-0-66-80">Menkes disease</span> is ameliorated by COMMD1 as a result of improved protein expression. | CTD_human;ORPHANET;UNIPROT |
null | null | Negative | MESH:D014657 | null | null | Kawasaki disease vasculitis | 216799 | null | NLRP3 | null | 28,148,962 | In conclusion, QUC inhibits both the NLRP3 and AIM2 inflammasome by preventing ASC oligomerization and may be a potential therapeutic candidate for Kawasaki disease vasculitis and other IL-1 mediated inflammatory diseases. | null | null | null |
null | null | Negative | MESH:D004802 | null | null | eosinophilia | 216799 | null | NLRP3 | null | 28,194,433 | This correlated with blunted induction of NF-kB, the NLRP3 inflammasome, and eosinophilia in transgenic mice. | null | null | null |
1 | 0 | Biomarker | C0948089 | Acute Coronary Syndrome | disease | ACS | 7431 | VIM | vimentin | CTD_human | 21,751,358 | The expression levels of proteins involved in cellular cytoskeleton (F-actin capping, ?-tubulin, ?-tubulin isotypes 1 and 2, vinculin, vimentin and two Ras-related protein Rab-7b isotypes), glycolysis pathway (glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase and two pyruvate kinase isotypes) and cellular-related antioxidant system (manganese superoxide dismutase) and even the expression and activity of glutathione-S-transferase were significantly reduced in platelets from ACS patients compared to CAD patients. | 0.2 | The expression levels of proteins involved in cellular cytoskeleton (F-actin capping, β-tubulin, α-tubulin isotypes 1 and 2, vinculin, <span class="gene" id="21751358-4-135-143">vimentin</span> and two Ras-related protein Rab-7b isotypes), glycolysis pathway (glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase and two pyruvate kinase isotypes) and cellular-related antioxidant system (manganese superoxide dismutase) and even the expression and activity of glutathione-S-transferase were significantly reduced in platelets from <span class="disease" id="21751358-4-492-495">ACS</span> patients compared to CAD patients. | CTD_human |
null | null | Negative | MESH:D011125 | null | null | APC | 23635 | null | SSBP2 | null | 28,147,335 | MATERIALS AND METHODS: Sixteen primary matched tumor and serum were analyzed by quantitative methylation specific PCR (QMSP) to determine analytical and clinical sensitivity of the genes tested (SSBP2, MCAM, ERa, ERb, APC, CCND2, MGMT, GSTP1, p16 and RARb2). | null | null | null |
1 | 0 | Biomarker | C0028754 | Obesity | disease | obesity | 2778 | GNAS | GNAS | CTD_human | 17,062,894 | The CC genotype of the GNAS T393C polymorphism is associated with obesity and insulin resistance in women with polycystic ovary syndrome. | 0.401923 | The CC genotype of the <span class="gene" id="17062894-0-23-27">GNAS</span> T393C polymorphism is associated with <span class="disease" id="17062894-0-66-73">obesity</span> and insulin resistance in women with polycystic ovary syndrome. | CTD_human;HPO |
null | null | Negative | MESH:C537354 | null | null | ND | 11450 | null | adiponectin | null | 28,170,448 | HFD-fed mice showed higher serum concentrations of leptin (P < 0.001) and insulin (P < 0.01) than those in the ND group, whereas serum IGF-1 and adiponectin concentrations did not differ between the two dietary groups. | null | null | null |
null | null | Negative | OMIM:604588 | null | null | mitosis | 2324 | null | VEGFR3 | null | 28,004,478 | CS2164 inhibited the angiogenesis-related kinases (VEGFR2, VEGFR1, VEGFR3, PDGFRa and c-Kit), mitosis-related kinase Aurora B and chronic inflammation-related kinase CSF-1R in a high potency manner with the IC50 at a single-digit nanomolar range. | null | null | null |
null | null | Negative | MESH:D009369 | null | null | primary tumors | 16728 | null | L1CAM | null | 28,022,953 | One of these, L1CAM, a neuronal cell adhesion molecule involved in axon motility and tracking, was upregulated 1.6-fold in the brain metastases relative to the primary tumors (p= 0.037). | null | null | null |
1 | 0 | Biomarker | C0345967 | Malignant mesothelioma | disease | malignant mesothelioma | 794 | CALB2 | calretinin | CTD_human | 22,784,439 | Immunohistochemical analysis for epithelial membrane antigen, calretinin, vimentin, ?-catenin, melan-A, glucose transporter-1, cytokeratin CAM5.2, Wilms tumor antigen-1, D2-40, CD146, progesterone receptor, estrogen receptor, and cytokeratin 5/6 was indicative of malignant mesothelioma. | 0.201374 | Immunohistochemical analysis for epithelial membrane antigen, <span class="gene" id="22784439-5-62-72">calretinin</span>, vimentin, β-catenin, melan-A, glucose transporter-1, cytokeratin CAM5.2, Wilms tumor antigen-1, D2-40, CD146, progesterone receptor, estrogen receptor, and cytokeratin 5/6 was indicative of <span class="disease" id="22784439-5-264-286">malignant mesothelioma</span>. | CTD_human |
null | null | Negative | MESH:D014842 | null | null | von Willebrand | 1351 | null | VIII | null | 28,043,678 | We have examined the association between the coagulation markers fibrinogen, von Willebrand Factor (VWF), Factors VII, VIII and IX, D-dimer, activated protein C (APC) and activated partial thromboplastin time (aPPT) with NT-proBNP and incident HF. | null | null | null |