Datasets:
Brizape
/
amia_split_0404

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26416897
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26416897
[ "TBK1", "rs7486100", "was", "significantly", "associated", "with", "overall", "survival", "in", "95", "KRAS", "wild-type", "patients", "of", "TRIBE", "cohort", "in", "univariate", "analysis", "and", "had", "a", "strong", "trend", "in", "multivariable", "analysis;"...
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TBK1 rs7486100 was significantly associated with overall survival in 95 KRAS wild-type patients of TRIBE cohort in univariate analysis and had a strong trend in multivariable analysis; furthermore, the association of the T allele was observed for progression-free survival (PFS) in both univariate and multivariable anal...
26416897
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
26416897
[ "Our", "study", "demonstrates", "for", "the", "first", "time", "that", "variations", "in", "genes", "regulating", "TAMs-related", "functions", "are", "significantly", "associated", "with", "clinical", "outcomes", "in", "mCRC", "patients", "treated", "with", "bevaciz...
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Our study demonstrates for the first time that variations in genes regulating TAMs-related functions are significantly associated with clinical outcomes in mCRC patients treated with bevacizumab-containing chemotherapy. These results also suggest that some TAM-related gene variations CCL2 variations in genes involved...
26416897
[ "##", "PATIENTS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## PATIENTS AND METHODS
26416897
[ "We", "analyzed", "genomic", "DNA", "extracted", "from", "samples", "of", "patients", "receiving", "bevacizumab", "plus", "FOLFIRI", "as", "a", "first-line", "treatment", "using", "PCR-based", "direct", "sequencing.", "Twelve", "functional", "single-nucleotide", "poly...
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We analyzed genomic DNA extracted from samples of patients receiving bevacizumab plus FOLFIRI as a first-line treatment using PCR-based direct sequencing. Twelve functional single-nucleotide polymorphisms in eight genes (CCL2, CCR2, HRG , PIGF , NFKB1, TBK1, CCL18, and IRF3) were tested for associations with clinical o...
26416897
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26416897
[ "TBK1", "rs7486100", "was", "significantly", "associated", "with", "overall", "survival", "in", "95", "KRAS", "wild-type", "patients", "of", "TRIBE", "cohort", "in", "univariate", "analysis", "and", "had", "a", "strong", "trend", "in", "multivariable", "analysis;"...
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TBK1 rs7486100 was significantly associated with overall survival in 95 KRAS wild-type patients of TRIBE cohort in univariate analysis and had a strong trend in multivariable analysis; furthermore, the association of the T allele was observed for progression-free survival (PFS) in both univariate and multivariable anal...
26416897
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
26416897
[ "Our", "study", "demonstrates", "for", "the", "first", "time", "that", "variations", "TBK1", ",", "CCL18,", "and", "IRF3)", "were", "tested", "for", "associations", "with", "clinical", "outcomes", "in", "a", "discovery", "cohort", "of", "228", "participants", ...
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Our study demonstrates for the first time that variations TBK1 , CCL18, and IRF3) were tested for associations with clinical outcomes in a discovery cohort of 228 participants in TRIBE trial (NCT00719797), then validated in 248 KRAS exon2 (KRAS) wild-type participants in FIRE3 trial (NCT00433927). FIRE3-cetuximab cohor...
26416897
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26416897
[ "TBK1", "rs7486100", "was", "significantly", "associated", "with", "overall", "survival", "in", "95", "KRAS", "wild-type", "patients", "of", "TRIBE", "cohort", "in", "univariate", "analysis", "and", "had", "a", "strong", "trend", "in", "multivariable", "analysis;"...
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TBK1 rs7486100 was significantly associated with overall survival in 95 KRAS wild-type patients of TRIBE cohort in univariate analysis and had a strong trend in multivariable analysis; furthermore, the association of the T allele was observed for progression-free survival (PFS) in both univariate and multivariable anal...
26416897
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26416897
[ "TBK1", "rs7486100", "was", "significantly", "associated", "with", "overall", "survival", "in", "95", "KRAS", "wild-type", "patients", "of", "TRIBE", "cohort", "in", "univariate", "analysis", "and", "had", "a", "strong", "trend", "in", "multivariable", "analysis;"...
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TBK1 rs7486100 was significantly associated with overall survival in 95 KRAS wild-type patients of TRIBE cohort in univariate analysis and had a strong trend in multivariable analysis; furthermore, the association of the T allele was observed for progression-free survival (PFS) in both univariate and multivariable anal...
26416897
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
26416897
[ "Our", "study", "demonstrates", "for", "the", "first", "time", "that", "variations", "in", "genes", "regulating", "TAMs-related", "functions", "are", "significantly", "associated", "with", "clinical", "outcomes", "in", "mCRC", "patients", "treated", "with", "bevaciz...
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Our study demonstrates for the first time that variations in genes regulating TAMs-related functions are significantly associated with clinical outcomes in mCRC patients treated with bevacizumab-containing chemotherapy. These results also suggest that some TAM-related gene variations may predict outcomes of bevacizumab...
26416897
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26416897
[ "TBK1", "rs7486100", "TBK1", " ", "rs7486100", "was", "significantly", "associated", "with", "overall", "survival", "in", "95", "KRAS", " ", "wild-type", "patients", "of", "TRIBE", "cohort", "in", "univariate", "analysis", "and", "had", "a", "strong", "trend", ...
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TBK1 rs7486100 TBK1 rs7486100 was significantly associated with overall survival in 95 KRAS wild-type patients of TRIBE cohort in univariate analysis and had a strong trend in multivariable analysis; furthermore, the association of the T allele was observed for progression-free survival (PFS) in both univariate and...
26416897
[ "##", "PATIENTS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## PATIENTS AND METHODS
26416897
[ "We", "analyzed", "genomic", "DNA", "extracted", "from", "samples", "of", "patients", "receiving", "bevacizumab", "plus", "FOLFIRI", "as", "a", "first-line", "treatment", "using", "PCR-based", "direct", "sequencing.", "Twelve", "functional", "single-nucleotide", "poly...
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We analyzed genomic DNA extracted from samples of patients receiving bevacizumab plus FOLFIRI as a first-line treatment using PCR-based direct sequencing. Twelve functional single-nucleotide polymorphisms in eight genes (CCL2, CCR2, HRG, PIGF, NFKB1, TBK1, CCL18, and IRF3) were tested for associations with clinical out...
26416897
[ "Tumor-associated", "macrophages", "(TAMs)", "with", "the", "M2-like", "phenotype", "are", "regulated", "by", "mainly", "NF-kB", "pathway", "including", "TBK1,", "which", "can", "influence", "tumor", "progression", "by", "secretion", "of", "proangiogenic", "factors", ...
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Tumor-associated macrophages (TAMs) with the M2-like phenotype are regulated by mainly NF-kB pathway including TBK1, which can influence tumor progression by secretion of proangiogenic factors such as vascular endothelial growth factor. The CCL2/CCR2 axis, histidine-rich glycoprotein (HRG), and placenta growth factor...
26416897
[ "##", "PATIENTS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## PATIENTS AND METHODS
26416897
[ "We", "analyzed", "genomic", "DNA", "extracted", "from", "samples", "of", "patients", "receiving", "bevacizumab", "plus", "FOLFIRI", "as", "a", "first-line", "treatment", "using", "PCR-based", "direct", "sequencing.", "Twelve", "functional", "single-nucleotide", "poly...
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We analyzed genomic DNA extracted from samples of patients receiving bevacizumab plus FOLFIRI as a first-line treatment using PCR-based direct sequencing. Twelve functional single-nucleotide polymorphisms in eight genes (CCL2, CCR2, HRG, PIGF, NFKB1, TBK1, CCL18, and IRF3) were tested for associations with clinical out...
26416897
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26416897
[ "TBK1", "rs7486100", "was", "significantly", "associated", "with", "overall", "survival", "in", "95", "KRAS", "wild-type", "patients", "of", "TRIBE", "cohort", "in", "univariate", "analysis", "and", "had", "a", "strong", "trend", "in", "multivariable", "analysis;"...
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TBK1 rs7486100 was significantly associated with overall survival in 95 KRAS wild-type patients of TRIBE cohort in univariate analysis and had a strong trend in multivariable analysis; furthermore, the association of the T allele was observed for progression-free survival (PFS) in both univariate and multivariable anal...
26416897
[ "##", "PATIENTS", "AND", "METHODS" ]
[ 0, 0, 0, 0 ]
## PATIENTS AND METHODS
26416897
[ "We", "analyzed", "genomic", "DNA", "extracted", "from", "samples", "of", "patients", "receiving", "bevacizumab", "plus", "FOLFIRI", "as", "a", "first-line", "treatment", "using", "PCR-based", "direct", "sequencing.", "Twelve", "functional", "single-nucleotide", "poly...
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We analyzed genomic DNA extracted from samples of patients receiving bevacizumab plus FOLFIRI as a first-line treatment using PCR-based direct sequencing. Twelve functional single-nucleotide polymorphisms in eight genes (CCL2, CCR2, HRG, PIGF, NFKB1, TBK1, CCL18, and IRF3) were tested for associations with clinical o...
26416897
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26416897
[ "TBK1", "rs7486100", "was", "significantly", "associated", "with", "overall", "survival", "in", "95", "KRAS", "wild-type", "patients", "of", "TRIBE", "cohort", "in", "univariate", "analysis", "and", "had", "a", "strong", "trend", "in", "multivariable", "analysis;"...
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TBK1 rs7486100 was significantly associated with overall survival in 95 KRAS wild-type patients of TRIBE cohort in univariate analysis and had a strong trend in multivariable analysis; furthermore, the association of the T allele was observed for progression-free survival (PFS) in both univariate and multivariable anal...
26416897
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
26416897
[ "TBK1", "rs7486100", "was", "significantly", "associated", "with", "overall", "survival", "in", "95", "KRAS", "wild-type", "patients", "of", "TRIBE", "cohort", "in", "univariate", "analysis", "and", "had", "a", "strong", "trend", "in", "multivariable", "analysis;"...
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TBK1 rs7486100 was significantly associated with overall survival in 95 KRAS wild-type patients of TRIBE cohort in univariate analysis and had a strong trend in multivariable analysis; furthermore, the association of the T allele was observed for progression-free survival (PFS) in both univariate and multivariable anal...
26416897
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
26416897
[ "Our", "study", "demonstrates", "for", "the", "first", "time", "that", "variations", "in", "genes", "regulating", "TAMs-related", "functions", "are", "significantly", "associated", "with", "clinical", "outcomes", "in", "mCRC", "patients", "treated", "with", "bevaciz...
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Our study demonstrates for the first time that variations in genes regulating TAMs-related functions are significantly associated with clinical outcomes in mCRC patients treated with bevacizumab-containing chemotherapy. These results also suggest that some TAM-related gene variations may predict outcomes of bevacizumab...
26416897
[]
[]
18268114
[ "Large-scale", "evaluation", "of", "genetic", "variants", "in", "candidate", "genes", "for", "colorectal", "cancer", "risk", "in", "the", "Nurses'", "Health", "Study", "and", "the", "Health", "Professionals'", "Follow-up", "Study." ]
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Large-scale evaluation of genetic variants in candidate genes for colorectal cancer risk in the Nurses' Health Study and the Health Professionals' Follow-up Study.
18268114
[ "Advances", "in", "genomics", "offer", "new", "strategies", "for", "assessing", "the", "association", "of", "common", "genetic", "variations", "at", "multiple", "loci", "and", "risk", "of", "many", "diseases,", "including", "colorectal", "cancer.", "Low-penetrance",...
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Advances in genomics offer new strategies for assessing the association of common genetic variations at multiple loci and risk of many diseases, including colorectal cancer. Low-penetrance alleles of genes in many biological pathways, such as DNA repair, metabolism, inflammation, cell cycle, apoptosis, and Wnt signalin...
18268114
[ "Advances", "in", "genomics", "offer", "new", "strategies", "for", "assessing", "the", "association", "of", "common", "genetic", "variations", "at", "multiple", "loci", "and", "risk", "of", "many", "diseases,", "including", "colorectal", "cancer.", "Low-penetrance",...
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Advances in genomics offer new strategies for assessing the association of common genetic variations at multiple loci and risk of many diseases, including colorectal cancer. Low-penetrance alleles of genes in many biological pathways, such as DNA repair, metabolism, inflammation, cell cycle, apoptosis, and Wnt signalin...
18268114
[]
[]
19276868
[ "Identification", "and", "characterization", "of", "a", "novel", "anticancer", "agent", "with", "selectivity", "against", "deleted", "in", "pancreatic", "cancer", "locus", "4", "(DPC4)-deficient", "pancreatic", "and", "colon", "cancer", "cells.", "\n\n\n", "##", "OB...
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Identification and characterization of a novel anticancer agent with selectivity against deleted in pancreatic cancer locus 4 (DPC4)-deficient pancreatic and colon cancer cells. ## OBJECTIVES
19276868
[ "The", "deleted", "in", "pancreatic", "cancer", "locus", "4", "(DPC4)/SMAD4", "tumor", "suppressor", "gene", "is", "frequently", "inactivated", "in", "pancreatic", "(approximately", "55%)", "and", "colorectal", "cancers", "(approximately", "30%).", "Like", "other", ...
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The deleted in pancreatic cancer locus 4 (DPC4)/SMAD4 tumor suppressor gene is frequently inactivated in pancreatic (approximately 55%) and colorectal cancers (approximately 30%). Like other tumor suppressor genes, the loss-of-function mutations found in the DPC4 gene are specific to cancer cells. This provides an at...
19276868
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19276868
[ "An", "unbiased", "chemical", "screening", "using", "isogenic", "cell", "lines", "that", "only", "differ", "in", "the", "DPC4", " ", "gene", "was", "carried", "out", "to", "identify", "positive", "hits.", "Selected", "hits", "were", "further", "verified", "in"...
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An unbiased chemical screening using isogenic cell lines that only differ in the DPC4 gene was carried out to identify positive hits. Selected hits were further verified in additional isogenic cell lines and characterized in cancer cells using several different cellular assays.
19276868
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
19276868
[ "A", "lead", "molecule,", "UA62784,", "was", "identified", "to", "be", "selectively", "cytotoxic", "against", "cancer", "cells", "with", "deficient", "DPC4", ".", "UA62784", "preferentially", "induces", "cell", "cycle", "arrest", "and", "apoptosis", "in", "cells",...
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A lead molecule, UA62784, was identified to be selectively cytotoxic against cancer cells with deficient DPC4 . UA62784 preferentially induces cell cycle arrest and apoptosis in cells with deficient DPC4. It also selectively reduces the clonogenicity of DPC4 DPC4 . It also selectively reduces the clonogenicity of DPC4-...
19276868
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19276868
[ "An", "unbiased", "chemical", "screening", "using", "isogenic", "cell", "lines", "that", "only", "differ", "in", "the", "DPC4", "gene", "was", "carried", "out", "to", "identify", "positive", "hits.", "Selected", "hits", "were", "further", "verified", "in", "ad...
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An unbiased chemical screening using isogenic cell lines that only differ in the DPC4 gene was carried out to identify positive hits. Selected hits were further verified in additional isogenic cell lines and characterized in cancer cells using several different cellular assays.
19276868
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
19276868
[ "A", "lead", "molecule,", "UA62784,", "was", "identified", "to", "be", "selectively", "cytotoxic", "against", "cancer", "cells", "with", "deficient", "DPC4.", "UA62784", "preferentially", "induces", "cell", "cycle", "arrest", "and", "apoptosis", "in", "cells", "wi...
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A lead molecule, UA62784, was identified to be selectively cytotoxic against cancer cells with deficient DPC4. UA62784 preferentially induces cell cycle arrest and apoptosis in cells with deficient DPC4. It also selectively reduces the clonogenicity of DPC4-deficient cells on soft agar when compared with cells with wil...
19276868
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
19276868
[ "UA62784", "is", "a", "small", "molecule", "that", "selectively", "kills", "DPC4", "DPC4", "DPC4", ")-deficient", "pancreatic", "and", "colon", "cancer", "cells.", "\n\n\n", "##", "OBJECTIVES" ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
UA62784 is a small molecule that selectively kills DPC4 DPC4 DPC4 )-deficient pancreatic and colon cancer cells. ## OBJECTIVES
19276868
[ "The", "deleted", "in", "pancreatic", "cancer", "locus", "4", "(DPC4)/SMAD4", "tumor", "suppressor", "gene", "is", "frequently", "inactivated", "in", "pancreatic", "(approximately", "55%)", "and", "colorectal", "cancers", "(approximately", "30%).", "Like", "other", ...
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The deleted in pancreatic cancer locus 4 (DPC4)/SMAD4 tumor suppressor gene is frequently inactivated in pancreatic (approximately 55%) and colorectal cancers (approximately 30%). Like other tumor suppressor genes, the loss-of-function mutations found in the DPC4 gene are specific to cancer cells. This provides an attr...
19276868
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19276868
[ "An", "unbiased", "chemical", "screening", "using", "isogenic", "cell", "lines", "that", "only", "differ", "in", "the", "DPC4", "gene", "was", "carried", "out", "to", "identify", "positive", "hits.", "Selected", "hits", "were", "further", "verified", "in", "ad...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
An unbiased chemical screening using isogenic cell lines that only differ in the DPC4 gene was carried out to identify positive hits. Selected hits were further verified in additional isogenic cell lines and characterized in cancer cells using several different cellular assays.
19276868
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
19276868
[ "A", "lead", "molecule,", "UA62784,", "was", "identified", "to", "be", "selectively", "cytotoxic", "against", "cancer", "cells", "with", "deficient", "DPC4.", "UA62784", "preferentially", "induces", "cell", "cycle", "arrest", "and", "apoptosis", "in", "cells", "wi...
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A lead molecule, UA62784, was identified to be selectively cytotoxic against cancer cells with deficient DPC4. UA62784 preferentially induces cell cycle arrest and apoptosis in cells with deficient DPC4. It also selectively reduces the clonogenicity of DPC4-deficient cells on soft agar when compared with cells with wil...
19276868
[ "The", "deleted", "in", "pancreatic", "cancer", "locus", "4", "(DPC4)/", "SMAD4", " ", "tumor", "suppressor", "gene", "is", "frequently", "inactivated", "in", "pancreatic", "(approximately", "55%)", "and", "colorectal", "cancers", "(approximately", "30%).", "Like", ...
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The deleted in pancreatic cancer locus 4 (DPC4)/ SMAD4 tumor suppressor gene is frequently inactivated in pancreatic (approximately 55%) and colorectal cancers (approximately 30%). Like other tumor suppressor genes, the loss-of-function mutations found in the DPC4 gene are specific to cancer cells. This provides an a...
19276868
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19276868
[ "An", "unbiased", "chemical", "screening", "using", "isogenic", "cell", "lines", "that", "only", "differ", "in", "the", "DPC4", "gene", "was", "carried", "out", "to", "identify", "positive", "hits.", "Selected", "hits", "were", "further", "verified", "in", "ad...
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An unbiased chemical screening using isogenic cell lines that only differ in the DPC4 gene was carried out to identify positive hits. Selected hits were further verified in additional isogenic cell lines and characterized in cancer cells using several different cellular assays.
19276868
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
19276868
[ "A", "lead", "molecule,", "UA62784,", "was", "identified", "to", "be", "selectively", "cytotoxic", "against", "cancer", "cells", "with", "deficient", "DPC4.", "UA62784", "preferentially", "induces", "cell", "cycle", "arrest", "and", "apoptosis", "in", "cells", "wi...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
A lead molecule, UA62784, was identified to be selectively cytotoxic against cancer cells with deficient DPC4. UA62784 preferentially induces cell cycle arrest and apoptosis in cells with deficient DPC4. It also selectively reduces the clonogenicity of DPC4-deficient cells on soft agar when compared with cells with wil...
19276868
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
19276868
[ "UA62784", "is", "a", "small", "molecule", "that", "selectively", "kills", "DPC4-deficient", "cancer", "cells.", "Its", "potent", "activity", "and", "relatively", "low", "molecular", "weight", "make", "it", "a", "decent", "candidate", "for", "further", "lead", "...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
UA62784 is a small molecule that selectively kills DPC4-deficient cancer cells. Its potent activity and relatively low molecular weight make it a decent candidate for further lead optimization.
19276868
[]
[]
8495305
[ "Expression", "of", "p53", "in", "colorectal", "cancer", "and", "dysplasia", "complicating", "ulcerative", "colitis." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Expression of p53 in colorectal cancer and dysplasia complicating ulcerative colitis.
8495305
[ "An", "immunohistochemical", "method", "using", "Pab1801,", "a", "monoclonal", "antibody", "specific", "to", "the", "human", "p53", "protein,", "was", "applied", "to", "detect", "p53", " ", "expression", "in", "colorectal", "cancer", "and", "dysplasia", "complicat...
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An immunohistochemical method using Pab1801, a monoclonal antibody specific to the human p53 protein, was applied to detect p53 expression in colorectal cancer and dysplasia complicating ulcerative colitis. Of 20 tissue samples with dysplasia, six showed positive immunoreactivity. Archival paraffin-embedded tissue bl...
8495305
[ "An", "immunohistochemical", "method", "using", "Pab1801,", "a", "monoclonal", "antibody", "specific", "to", "the", "human", "p53", " ", "protein,", "was", "applied", "to", "detect", "p53", "expression", "in", "colorectal", "cancer", "and", "dysplasia", "complicat...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...
An immunohistochemical method using Pab1801, a monoclonal antibody specific to the human p53 protein, was applied to detect p53 expression in colorectal cancer and dysplasia complicating ulcerative colitis. Of 20 tissue samples with dysplasia, six showed positive immunoreactivity. Archival paraffin-embedded tissue bl...
8495305
[]
[]
19706845
[ "A", "novel", "polymorphism", "rs1329149", "of", "CYP2E1", "and", "a", "known", "polymorphism", "rs671", "of", "ALDH2", "of", "alcohol", "metabolizing", "enzymes", "are", "associated", "with", "colorectal", "cancer", "in", "a", "southwestern", "Chinese", "populati...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. ## BACKGROUND
19706845
[ "To", "screen", "for", "tagging", "single", "nucleotide", "polymorphisms", "(tagSNP)", "in", "the", "major", "alcohol", "metabolizing", "enzymes:", "ADH1B,", "ALDH2,", "and", "CYP2E1,", "and", "to", "evaluate", "the", "association", "between", "these", "tagSNPs", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
To screen for tagging single nucleotide polymorphisms (tagSNP) in the major alcohol metabolizing enzymes: ADH1B, ALDH2, and CYP2E1, and to evaluate the association between these tagSNPs and colorectal cancer (CRC) in a southwestern Chinese population.
19706845
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19706845
[ "A", "hospital-based", "case-control", "study", "of", "440", "CRC", "patients", "and", "800", "cancer-free", "controls", "was", "conducted.", "Personal", "information", "was", "collected", "by", "a", "Semi-Quantitative", "Food", "Frequency", "Questionnaire.", "The", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...
A hospital-based case-control study of 440 CRC patients and 800 cancer-free controls was conducted. Personal information was collected by a Semi-Quantitative Food Frequency Questionnaire. The tagSNPs were screened in the HapMap with Haploview by setting the minor allele frequency at 0.03 with the highest score of r(2) ...
19706845
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
19706845
[ "Sixteen", "tagSNPs", "were", "selected,", "and", "13", "were", "successfully", "genotyped.", "A", "novel", "CYP2E1", "locus", "rs1329149", "and", "a", "known", "ALDH2", "locus", "rs671", "were", "found", "to", "be", "significantly", "associated", "with", "CRC",...
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Sixteen tagSNPs were selected, and 13 were successfully genotyped. A novel CYP2E1 locus rs1329149 and a known ALDH2 locus rs671 were found to be significantly associated with CRC risk. The adjusted OR was 1.86 (95% CI, 1.12-3.09) for the rs671 A/A genotype and 4.04 for the rs1329149 T/T genotype (95% CI, 2.44-6.70), co...
19706845
[ "To", "screen", "for", "tagging", "single", "nucleotide", "polymorphisms", "(tagSNP)", "in", "the", "major", "alcohol", "metabolizing", "enzymes:", "ADH1B,", "ALDH2,", "and", "CYP2E1,", "and", "to", "evaluate", "the", "association", "between", "these", "tagSNPs", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
To screen for tagging single nucleotide polymorphisms (tagSNP) in the major alcohol metabolizing enzymes: ADH1B, ALDH2, and CYP2E1, and to evaluate the association between these tagSNPs and colorectal cancer (CRC) in a southwestern Chinese population.
19706845
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19706845
[ "A", "hospital-based", "case-control", "study", "of", "440", "CRC", "patients", "and", "800", "cancer-free", "controls", "was", "conducted.", "Personal", "information", "was", "collected", "by", "a", "Semi-Quantitative", "Food", "Frequency", "Questionnaire.", "The", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...
A hospital-based case-control study of 440 CRC patients and 800 cancer-free controls was conducted. Personal information was collected by a Semi-Quantitative Food Frequency Questionnaire. The tagSNPs were screened in the HapMap with Haploview by setting the minor allele frequency at 0.03 with the highest score of r(2) ...
19706845
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
19706845
[ "Sixteen", "tagSNPs", "were", "selected,", "and", "13", "were", "successfully", "genotyped.", "A", "novel", "CYP2E1", "locus", "rs1329149", "and", "a", "known", "ALDH2", "locus", "rs671", "were", "found", "to", "be", "significantly", "associated", "with", "CRC",...
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Sixteen tagSNPs were selected, and 13 were successfully genotyped. A novel CYP2E1 locus rs1329149 and a known ALDH2 locus rs671 were found to be significantly associated with CRC risk. The adjusted OR was 1.86 (95% CI, 1.12-3.09) for the rs671 A/A genotype and 4.04 for the rs1329149 T/T genotype (95% CI, 2.44-6.70), ...
19706845
[ "##", "CONCLUSION" ]
[ 0, 0 ]
## CONCLUSION
19706845
[ "The", "results", "of", "this", "study", "suggest", "that", "rs671", " ", "A/A", "and", "the", "first", "reported", "locus", "rs1329149", "rs1329149", " ", "of", "CYP2E1", " ", "and", "a", "known", "polymorphism", "rs671", " ", "of", "ALDH2", " ", "of", ...
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The results of this study suggest that rs671 A/A and the first reported locus rs1329149 rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. ## BACKGROUND
19706845
[ "To", "screen", "for", "tagging", "single", "nucleotide", "polymorphisms", "(tag", "SNP", "single", "nucleotide", "polymorphisms", " ", "(tagSNP)", "in", "the", "major", "alcohol", "metabolizing", "enzymes:", "ADH1B,", "ALDH2,", "and", "CYP2E1,", "and", "to", "eva...
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To screen for tagging single nucleotide polymorphisms (tag SNP single nucleotide polymorphisms (tagSNP) in the major alcohol metabolizing enzymes: ADH1B, ALDH2, and CYP2E1, and to evaluate the association between these tagSNPs and colorectal cancer (CRC) in a southwestern Chinese population.
19706845
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19706845
[ "A", "hospital-based", "case-control", "study", "of", "440", "CRC", "patients", "and", "800", "cancer-free", "controls", "was", "conducted.", "Personal", "information", "was", "collected", "by", "a", "Semi-Quantitative", "Food", "Frequency", "Questionnaire.", "The", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 3, 1, 0, 0, 0, 0, 0...
A hospital-based case-control study of 440 CRC patients and 800 cancer-free controls was conducted. Personal information was collected by a Semi-Quantitative Food Frequency Questionnaire. The tagSNPs were screened in the HapMap with Haploview by setting the minor allele frequency at 0.03 with the highest score of r(2) ...
19706845
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19706845
[ "A", "hospital-based", "case-control", "study", "of", "440", "CRC", "patients", "and", "800", "cancer-free", "controls", "was", "conducted.", "Personal", "information", "was", "collected", "by", "a", "Semi-Quantitative", "Food", "Frequency", "Questionnaire.", "The", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...
A hospital-based case-control study of 440 CRC patients and 800 cancer-free controls was conducted. Personal information was collected by a Semi-Quantitative Food Frequency Questionnaire. The tagSNPs were screened in the HapMap with Haploview by setting the minor allele frequency at 0.03 with the highest score of r(2) ...
19706845
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
19706845
[ "Sixteen", "tag", "SNPs", "ADH1B", ",", "ALDH2,", "and", "CYP2E1,", "and", "to", "evaluate", "the", "association", "between", "these", "tagSNPs", "and", "colorectal", "cancer", "(CRC)", "in", "a", "southwestern", "Chinese", "population." ]
[ 0, 0, 3, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Sixteen tag SNPs ADH1B , ALDH2, and CYP2E1, and to evaluate the association between these tagSNPs and colorectal cancer (CRC) in a southwestern Chinese population.
19706845
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19706845
[ "A", "hospital-based", "case-control", "study", "of", "440", "CRC", "patients", "and", "800", "cancer-free", "controls", "was", "conducted.", "Personal", "information", "was", "collected", "by", "a", "Semi-Quantitative", "Food", "Frequency", "Questionnaire.", "The", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...
A hospital-based case-control study of 440 CRC patients and 800 cancer-free controls was conducted. Personal information was collected by a Semi-Quantitative Food Frequency Questionnaire. The tag SNPs were screened in the HapMap with Haploview by setting the minor allele frequency at 0.03 with the highest score of r(...
19706845
[ "##", "METHODS" ]
[ 0, 0 ]
## METHODS
19706845
[ "A", "hospital-based", "case-control", "study", "of", "440", "CRC", "patients", "and", "800", "cancer-free", "controls", "was", "conducted.", "Personal", "information", "was", "collected", "by", "a", "Semi-Quantitative", "Food", "Frequency", "Questionnaire.", "The", ...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0...
A hospital-based case-control study of 440 CRC patients and 800 cancer-free controls was conducted. Personal information was collected by a Semi-Quantitative Food Frequency Questionnaire. The tagSNPs were screened in the HapMap with Haploview by setting the minor allele frequency at 0.03 with the highest score of r(2) ...
19706845
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
19706845
[ "Sixteen", "tagSNPs", "were", "selected,", "and", "13", "were", "successfully", "genotyped.", "A", "novel", "CYP2E1", " ", "locus", "rs1329149", " ", "and", "a", "known", "ALDH2", " ", "locus", "rs671", " ", "were", "found", "to", "be", "significantly", "ass...
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Sixteen tagSNPs were selected, and 13 were successfully genotyped. A novel CYP2E1 locus rs1329149 and a known ALDH2 locus rs671 were found to be significantly associated with CRC risk. The adjusted OR was 1.86 (95% CI, 1.12-3.09) for the rs671 A/A genotype and 4.04 for the rs1329149 T/T genotype (95% CI, 2.44...
19706845
[ "##", "CONCLUSION" ]
[ 0, 0 ]
## CONCLUSION
19706845
[ "The", "results", "of", "this", "study", "suggest", "that", "rs671", "A/A", "and", "the", "first", "reported", "locus", "rs1329149", "T/T", "genotypes", "increase", "the", "susceptibility", "to", "CRC,", "and", "gene-environmental", "interaction", "between", "the"...
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The results of this study suggest that rs671 A/A and the first reported locus rs1329149 T/T genotypes increase the susceptibility to CRC, and gene-environmental interaction between the two loci and alcohol use existed for CRC in Southwestern Chinese. Larger studies are warranted to verify our findings.
19706845
[]
[]
18554281
[ "Colorectal", "cancer", "in", "HNPCC:", "cumulative", "lifetime", "incidence,", "survival", "and", "tumour", "distribution.", "A", "report", "of", "121", "families", "with", "proven", "mutations." ]
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Colorectal cancer in HNPCC: cumulative lifetime incidence, survival and tumour distribution. A report of 121 families with proven mutations.
18554281
[ "Hereditary", "non-polyposis", "colorectal", "cancer", "(HNPCC)", "is", "an", "autosomal", "dominant", "condition", "caused", "by", "inactivating", "mutations", "of", "DNA", "mismatch", "repair", "(MMR)", "genes.", "An", "accurate", "estimation", "of", "colorectal", ...
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Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant condition caused by inactivating mutations of DNA mismatch repair (MMR) genes. An accurate estimation of colorectal cancer risk for mutation carriers is essential for counselling and rationalizing screening programmes. Families were referred on...
18554281
[ "Hereditary", "non-polyposis", "colorectal", "cancer", "(HNPCC)", "is", "an", "autosomal", "dominant", "condition", "caused", "by", "inactivating", "mutations", " ", "of", "DNA", "mismatch", "repair", "(MMR)", "genes.", "An", "accurate", "estimation", "of", "colorec...
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Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant condition caused by inactivating mutations of DNA mismatch repair (MMR) genes. An accurate estimation of colorectal cancer risk for mutation carriers is essential for counselling and rationalizing screening programmes. Families were referred ...
18554281
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