Datasets:
Brizape
/
amia_split_0404

Dataset card Data Studio Files
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15702478
[ "Mutation", "analysis", "of", "p53,", "K-ras,", "and", "BRAF", "genes", "in", "colorectal", "cancer", "progression." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.
15702478
[ "Gene", "mutations", "in", "APC,", "K-ras,", "and", "p53", "are", "thought", "to", "be", "essential", "events", "for", "colorectal", "cancer", "development.", "Recent", "data", "seem", "to", "indicate", "that", "K-ras", "and", "p53", "mutations", "rarely", "co...
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Gene mutations in APC, K-ras, and p53 are thought to be essential events for colorectal cancer development. Recent data seem to indicate that K-ras and p53 mutations rarely co-exist in the same tumor, indicating that these alterations do not represent a synergistic evolutionary pathway. Moreover, an inverse relation be...
15702478
[ "Gene", "mutations", "in", "APC,", "K-ras,", "and", "p53", "are", "thought", "to", "be", "essential", "events", "for", "colorectal", "cancer", "development.", "Recent", "data", "seem", "to", "indicate", "that", "K-ras", "and", "p53", "mutations", "rarely", "co...
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Gene mutations in APC, K-ras, and p53 are thought to be essential events for colorectal cancer development. Recent data seem to indicate that K-ras and p53 mutations rarely co-exist in the same tumor, indicating that these alterations do not represent a synergistic evolutionary pathway. Moreover, an inverse relation be...
15702478
[ "Gene", "mutations", "in", "APC,", "K-ras,", "and", "p53", "are", "thought", "to", "be", "essential", "events", "for", "colorectal", "cancer", "development.", "Recent", "data", "seem", "to", "indicate", "that", "K-ras", "and", "p53", "mutations", "rarely", "co...
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Gene mutations in APC, K-ras, and p53 are thought to be essential events for colorectal cancer development. Recent data seem to indicate that K-ras and p53 mutations rarely co-exist in the same tumor, indicating that these alterations do not represent a synergistic evolutionary pathway. Moreover, an inverse relation be...
15702478
[ "Gene", "mutations", "in", "APC", "mutations", " ", "in", "APC,", "K-ras,", "and", "p53", "K-ras", ",", "and", "p53", "are", "thought", "to", "be", "essential", "events", "for", "colorectal", "cancer", "development.", "Recent", "data", "seem", "to", "indicat...
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Gene mutations in APC mutations in APC, K-ras, and p53 K-ras , and p53 are thought to be essential events for colorectal cancer development. Recent data seem to indicate that K-ras and p53 K-ras and p53 mutations rarely co-exist in the same tumor, indicating that these alterations do not represent a synergistic evo...
15702478
[]
[]
12530077
[ "Amplified", "Muc1-specific", "gene", "expression", "in", "colon", "cancer", "cells", "utilizing", "a", "binary", "system", "in", "adenoviral", "vectors." ]
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Amplified Muc1-specific gene expression in colon cancer cells utilizing a binary system in adenoviral vectors.
12530077
[ "Mucin-1", "is", "expressed", "in", "a", "variety", "of", "colon", "carcinomas", "and", "Muc-1", "Amplified", " ", "Muc1-specific", "gene", "expression", "in", "colon", "cancer", "cells", "utilizing", "a", "binary", "system", "in", "adenoviral", "vectors." ]
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Mucin-1 is expressed in a variety of colon carcinomas and Muc-1 Amplified Muc1-specific gene expression in colon cancer cells utilizing a binary system in adenoviral vectors.
12530077
[ "Mucin-1", "is", "expressed", "in", "a", "variety", "of", "colon", "carcinomas", "and", "Muc-1/DF3", "promoters", "have", "been", "utilized", "to", "reduce", "systemic", "toxicity", "through", "specific", "gene", "expression.", "To", "overcome", "weak", "expressio...
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Mucin-1 is expressed in a variety of colon carcinomas and Muc-1/DF3 promoters have been utilized to reduce systemic toxicity through specific gene expression. To overcome weak expression, which is much lower than the widely used cytomegalovirus-promoter (CMV), new adenoviral vectors containing a binary system of transg...
12530077
[ "Mucin-1", " ", "is", "expressed", "in", "a", "variety", "of", "colon", "carcinomas", "and", "Muc-1/", "DF3", " ", "promoters", "have", "been", "utilized", "to", "reduce", "systemic", "toxicity", "through", "specific", "gene", "expression.", "To", "overcome", ...
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Mucin-1 is expressed in a variety of colon carcinomas and Muc-1/ DF3 promoters have been utilized to reduce systemic toxicity through specific gene expression. To overcome weak expression, which is much lower than the widely used cytomegalovirus-promoter (CMV), new adenoviral vectors containing a binary system of t...
12530077
[]
[]
3399825
[ "Increased", "in", "vitro", "tetraploidy", "and", "mandibular", "osteomas", "in", "patients", "with", "and", "without", "colorectal", "diseases." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Increased in vitro tetraploidy and mandibular osteomas in patients with and without colorectal diseases.
3399825
[ "One", "hundred", "and", "seventy-six", "individuals", "with", "various", "colorectal", "diseases", "were", "investigated", "simultaneously", "for", "increased", "in", "vitro", "tetraploidy", "in", "dermal", "fibroblast", "cultures", "and", "for", "occult", "mandibula...
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One hundred and seventy-six individuals with various colorectal diseases were investigated simultaneously for increased in vitro tetraploidy in dermal fibroblast cultures and for occult mandibular osteomas. In only 10 of the 176 persons were both presumed markers of colorectal genetic predisposition present in the same...
3399825
[]
[]
24576032
[ "Summary", "of", "microsatellite", "instability", " ", "test", "results", "from", "laboratories", "participating", "in", "proficiency", "surveys:", "proficiency", "survey", "results", "from", "2005", "to", "2012.", "\n\n\n", "##", "CONTEXT" ]
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Summary of microsatellite instability test results from laboratories participating in proficiency surveys: proficiency survey results from 2005 to 2012. ## CONTEXT
24576032
[ "The", "College", "of", "American", "Pathologists", "surveys", "are", "the", "largest", "laboratory", "peer", "comparison", "programs", "in", "the", "world.", "These", "programs", "allow", "laboratories", "to", "regularly", "evaluate", "their", "performance", "and",...
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The College of American Pathologists surveys are the largest laboratory peer comparison programs in the world. These programs allow laboratories to regularly evaluate their performance and improve the accuracy of the patient test results they provide. Proficiency testing is offered twice a year to laboratories performi...
24576032
[ "##", "OBJECTIVE" ]
[ 0, 0 ]
## OBJECTIVE
24576032
[ "This", "report", "summarizes", "the", "results", "and", "trends", "in", "microsatellite", "instability", " ", "proficiency", "testing", "from", "participating", "laboratories", "from", "the", "inception", "of", "the", "program", "in", "2005", "through", "2012." ]
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This report summarizes the results and trends in microsatellite instability proficiency testing from participating laboratories from the inception of the program in 2005 through 2012.
24576032
[ "##", "DESIGN" ]
[ 0, 0 ]
## DESIGN
24576032
[ "We", "compiled", "and", "analyzed", "data", "for", "16", "surveys", "of", "microsatellite", "instability", "proficiency", "testing", "during", "2005", "to", "2012." ]
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We compiled and analyzed data for 16 surveys of microsatellite instability proficiency testing during 2005 to 2012.
24576032
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
24576032
[ "The", "number", "of", "laboratories", "participating", "in", "the", "microsatellite", "instability", "survey", "has", "more", "than", "doubled", "from", "42", "to", "104", "during", "the", "8", "years", "analyzed.", "An", "average", "of", "95.4%", "of", "the"...
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The number of laboratories participating in the microsatellite instability survey has more than doubled from 42 to 104 during the 8 years analyzed. An average of 95.4% of the laboratories correctly classified each of the survey test samples from the 2005A through 2012B proficiency challenges. In the 2011B survey, a low...
24576032
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
24576032
[ "In", "general,", "laboratories", "performed", "well", "in", "microsatellite", "instability", "microsatellite", "instability", " ", "proficiency", "testing", "during", "2005", "to", "2012." ]
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In general, laboratories performed well in microsatellite instability microsatellite instability proficiency testing during 2005 to 2012.
24576032
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
24576032
[ "The", "number", "of", "laboratories", "participating", "in", "the", "microsatellite", "instability", " ", "survey", "has", "more", "than", "doubled", "from", "42", "to", "104", "during", "the", "8", "years", "analyzed.", "An", "average", "of", "95.4%", "of", ...
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The number of laboratories participating in the microsatellite instability survey has more than doubled from 42 to 104 during the 8 years analyzed. An average of 95.4% of the laboratories correctly classified each of the survey test samples from the 2005A through 2012B proficiency challenges. In the 2011B survey, a l...
24576032
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
24576032
[ "In", "general,", "laboratories", "performed", "well", "in", "microsatellite", "instability", "testing.", "This", "testing", "will", "continue", "to", "be", "important", "in", "screening", "patients", "with", "colorectal", "and", "other", "cancers", "for", "Lynch", ...
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In general, laboratories performed well in microsatellite instability testing. This testing will continue to be important in screening patients with colorectal and other cancers for Lynch syndrome and guiding the management of patients with sporadic colorectal cancer.
24576032
[]
[]
17350669
[ "Fatty", "acid", "synthase", "overexpression", "in", "colorectal", "cancer", "is", "associated", "with", "microsatellite", "instability,", "independent", "of", "CpG", "island", "methylator", "phenotype." ]
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Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
17350669
[ "Overexpression", "of", "fatty", "acid", "synthase", "(FASN),", "a", "key", "enzyme", "for", "de", "novo", "lipogenesis,", "is", "observed", "in", "many", "cancers", "including", "colorectal", "cancer", "and", "is", "associated", "with", "poor", "clinical", "out...
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Overexpression of fatty acid synthase (FASN), a key enzyme for de novo lipogenesis, is observed in many cancers including colorectal cancer and is associated with poor clinical outcomes. Cellular FASN expression is physiologically upregulated in a state of energy excess. Obesity and excess energy balance have been know...
17350669
[ "Overexpression", "of", "fatty", "acid", "synthase", "(FASN),", "a", "key", "enzyme", "for", "de", "novo", "lipogenesis,", "is", "observed", "in", "many", "cancers", "including", "colorectal", "cancer", "and", "is", "associated", "with", "poor", "clinical", "out...
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Overexpression of fatty acid synthase (FASN), a key enzyme for de novo lipogenesis, is observed in many cancers including colorectal cancer and is associated with poor clinical outcomes. Cellular FASN expression is physiologically upregulated in a state of energy excess. Obesity and excess energy balance have been know...
17350669
[ "Overexpression", "of", "fatty", "acid", "synthase", "(FASN),", "a", "key", "enzyme", "for", "de", "novo", "lipogenesis,", "is", "observed", "in", "many", "cancers", "including", "colorectal", "cancer", "and", "is", "associated", "with", "poor", "clinical", "out...
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Overexpression of fatty acid synthase (FASN), a key enzyme for de novo lipogenesis, is observed in many cancers including colorectal cancer and is associated with poor clinical outcomes. Cellular FASN expression is physiologically upregulated in a state of energy excess. Obesity and excess energy balance have been know...
17350669
[ "Overexpression", "of", "fatty", "acid", "synthase", "(FASN),", "a", "key", "enzyme", "for", "de", "novo", "lipogenesis,", "is", "observed", "in", "many", "cancers", "including", "colorectal", "cancer", "and", "is", "associated", "with", "poor", "clinical", "out...
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Overexpression of fatty acid synthase (FASN), a key enzyme for de novo lipogenesis, is observed in many cancers including colorectal cancer and is associated with poor clinical outcomes. Cellular FASN FASN ), a key enzyme for de novo lipogenesis, is observed in many cancers including colorectal cancer and is associated...
17350669
[]
[]
9841584
[ "Benefits", "of", "colonoscopic", "surveillance", "and", "prophylactic", "colectomy", "in", "patients", "with", "hereditary", "nonpolyposis", "colorectal", "cancer", "mutations.", "\n\n\n", "##", "BACKGROUND" ]
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Benefits of colonoscopic surveillance and prophylactic colectomy in patients with hereditary nonpolyposis colorectal cancer mutations. ## BACKGROUND
9841584
[ "Predisposition", "genetic", "testing", "is", "now", "possible", "for", "many", "hereditary", "cancer", "syndromes,", "including", "hereditary", "nonpolyposis", "colorectal", "cancer.", "The", "optimal", "management", "of", "the", "elevated", "risk", "for", "cancer", ...
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Predisposition genetic testing is now possible for many hereditary cancer syndromes, including hereditary nonpolyposis colorectal cancer. The optimal management of the elevated risk for cancer in carriers of mutations for hereditary nonpolyposis colorectal cancer is unclear.
9841584
[ "##", "OBJECTIVE" ]
[ 0, 0 ]
## OBJECTIVE
9841584
[ "To", "assess", "the", "life", "expectancy", "and", "quality-adjusted", "life", "expectancy", "benefits", "derived", "from", "endoscopic", "surveillance", "and", "prophylactic", "colectomy", "for", "persons", "who", "carry", "a", "mutation", "associated", "with", "h...
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To assess the life expectancy and quality-adjusted life expectancy benefits derived from endoscopic surveillance and prophylactic colectomy for persons who carry a mutation associated with hereditary nonpolyposis colorectal cancer.
9841584
[ "##", "DESIGN" ]
[ 0, 0 ]
## DESIGN
9841584
[ "Decision", "analysis", "model.", "Lifetime", "risk", "for", "colorectal", "cancer,", "efficacy", "of", "surveillance", "and", "colectomy,", "stage-specific", "colorectal", "cancer", "mortality,", "and", "quality", "of", "life", "were", "included", "in", "the", "mod...
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Decision analysis model. Lifetime risk for colorectal cancer, efficacy of surveillance and colectomy, stage-specific colorectal cancer mortality, and quality of life were included in the model.
9841584
[ "##", "SETTING" ]
[ 0, 0 ]
## SETTING
9841584
[ "Decision", "about", "a", "cancer", "prevention", "strategy", "at", "the", "time", "of", "a", "positive", "result", "on", "genetic", "testing." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Decision about a cancer prevention strategy at the time of a positive result on genetic testing.
9841584
[ "##", "PATIENTS" ]
[ 0, 0 ]
## PATIENTS
9841584
[ "Carriers", "of", "a", "mutation", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "who", "were", "25", "years", "of", "age." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Carriers of a mutation for hereditary nonpolyposis colorectal cancer who were 25 years of age.
9841584
[ "##", "INTERVENTIONS" ]
[ 0, 0 ]
## INTERVENTIONS
9841584
[ "Immediate", "prophylactic", "colectomy;", "delayed", "colectomy", "on", "the", "basis", "of", "age,", "adenoma,", "or", "diagnosis", "of", "colorectal", "cancer;", "and", "endoscopic", "surveillance.", "Prophylactic", "surgical", "options", "were", "proctocolectomy", ...
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Immediate prophylactic colectomy; delayed colectomy on the basis of age, adenoma, or diagnosis of colorectal cancer; and endoscopic surveillance. Prophylactic surgical options were proctocolectomy with ileoanal anastomosis and subtotal colectomy with ileorectal anastomosis.
9841584
[ "##", "MEASUREMENTS" ]
[ 0, 0 ]
## MEASUREMENTS
9841584
[ "Life", "expectancy", "and", "quality-adjusted", "life", "expectancy." ]
[ 0, 0, 0, 0, 0, 0 ]
Life expectancy and quality-adjusted life expectancy.
9841584
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9841584
[ "All", "risk-reduction", "strategies", "led", "to", "large", "gains", "in", "life", "expectancy", "for", "carriers", "of", "a", "mutation", "for", "hereditary", "nonpolyposis", "colorectal", "cancer,", "with", "benefits", "ranging", "from", "13.5", "years", "for",...
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All risk-reduction strategies led to large gains in life expectancy for carriers of a mutation for hereditary nonpolyposis colorectal cancer, with benefits ranging from 13.5 years for surveillance to 15.6 years for prophylactic proctocolectomy at 25 years of age compared with no intervention. The benefits of colectomy ...
9841584
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9841584
[ "Colonoscopic", "surveillance", "is", "an", "effective", "method", "of", "reducing", "risk", "for", "cancer", "in", "carriers", "of", "a", "mutation", "mutations", " ", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "is", "unclear." ]
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Colonoscopic surveillance is an effective method of reducing risk for cancer in carriers of a mutation mutations for hereditary nonpolyposis colorectal cancer is unclear.
9841584
[ "##", "OBJECTIVE" ]
[ 0, 0 ]
## OBJECTIVE
9841584
[ "To", "assess", "the", "life", "expectancy", "and", "quality-adjusted", "life", "expectancy", "benefits", "derived", "from", "endoscopic", "surveillance", "and", "prophylactic", "colectomy", "for", "persons", "who", "carry", "a", "mutation", " ", "associated", "with...
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To assess the life expectancy and quality-adjusted life expectancy benefits derived from endoscopic surveillance and prophylactic colectomy for persons who carry a mutation associated with hereditary nonpolyposis colorectal cancer.
9841584
[ "##", "DESIGN" ]
[ 0, 0 ]
## DESIGN
9841584
[ "Decision", "analysis", "model.", "Lifetime", "risk", "for", "colorectal", "cancer,", "efficacy", "of", "surveillance", "and", "colectomy,", "stage-specific", "colorectal", "cancer", "mortality,", "and", "quality", "of", "life", "were", "included", "in", "the", "mod...
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Decision analysis model. Lifetime risk for colorectal cancer, efficacy of surveillance and colectomy, stage-specific colorectal cancer mortality, and quality of life were included in the model.
9841584
[ "##", "SETTING" ]
[ 0, 0 ]
## SETTING
9841584
[ "Decision", "about", "a", "cancer", "prevention", "strategy", "at", "the", "time", "of", "a", "positive", "result", "on", "genetic", "testing." ]
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Decision about a cancer prevention strategy at the time of a positive result on genetic testing.
9841584
[ "##", "PATIENTS" ]
[ 0, 0 ]
## PATIENTS
9841584
[ "Carriers", "of", "a", "mutation", " ", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "who", "were", "25", "years", "of", "age." ]
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Carriers of a mutation for hereditary nonpolyposis colorectal cancer who were 25 years of age.
9841584
[ "##", "INTERVENTIONS" ]
[ 0, 0 ]
## INTERVENTIONS
9841584
[ "Immediate", "prophylactic", "colectomy;", "delayed", "colectomy", "on", "the", "basis", "of", "age,", "adenoma,", "or", "diagnosis", "of", "colorectal", "cancer;", "and", "endoscopic", "surveillance.", "Prophylactic", "surgical", "options", "were", "proctocolectomy", ...
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Immediate prophylactic colectomy; delayed colectomy on the basis of age, adenoma, or diagnosis of colorectal cancer; and endoscopic surveillance. Prophylactic surgical options were proctocolectomy with ileoanal anastomosis and subtotal colectomy with ileorectal anastomosis.
9841584
[ "##", "MEASUREMENTS" ]
[ 0, 0 ]
## MEASUREMENTS
9841584
[ "Life", "expectancy", "and", "quality-adjusted", "life", "expectancy." ]
[ 0, 0, 0, 0, 0, 0 ]
Life expectancy and quality-adjusted life expectancy.
9841584
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9841584
[ "All", "risk-reduction", "strategies", "led", "to", "large", "gains", "in", "life", "expectancy", "for", "carriers", "of", "a", "mutation", "mutations", ".", "\n\n\n", "##", "BACKGROUND" ]
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All risk-reduction strategies led to large gains in life expectancy for carriers of a mutation mutations . ## BACKGROUND
9841584
[ "Predisposition", "genetic", "testing", "is", "now", "possible", "for", "many", "hereditary", "cancer", "syndromes,", "including", "hereditary", "nonpolyposis", "colorectal", "cancer.", "The", "optimal", "management", "of", "the", "elevated", "risk", "for", "cancer", ...
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Predisposition genetic testing is now possible for many hereditary cancer syndromes, including hereditary nonpolyposis colorectal cancer. The optimal management of the elevated risk for cancer in carriers of mutations for hereditary nonpolyposis colorectal cancer is unclear.
9841584
[ "##", "OBJECTIVE" ]
[ 0, 0 ]
## OBJECTIVE
9841584
[ "To", "assess", "the", "life", "expectancy", "and", "quality-adjusted", "life", "expectancy", "benefits", "derived", "from", "endoscopic", "surveillance", "and", "prophylactic", "colectomy", "for", "persons", "who", "carry", "a", "mutation", "associated", "with", "h...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
To assess the life expectancy and quality-adjusted life expectancy benefits derived from endoscopic surveillance and prophylactic colectomy for persons who carry a mutation associated with hereditary nonpolyposis colorectal cancer.
9841584
[ "##", "DESIGN" ]
[ 0, 0 ]
## DESIGN
9841584
[ "Decision", "analysis", "model.", "Lifetime", "risk", "for", "colorectal", "cancer,", "efficacy", "of", "surveillance", "and", "colectomy,", "stage-specific", "colorectal", "cancer", "mortality,", "and", "quality", "of", "life", "were", "included", "in", "the", "mod...
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Decision analysis model. Lifetime risk for colorectal cancer, efficacy of surveillance and colectomy, stage-specific colorectal cancer mortality, and quality of life were included in the model.
9841584
[ "##", "SETTING" ]
[ 0, 0 ]
## SETTING
9841584
[ "Decision", "about", "a", "cancer", "prevention", "strategy", "at", "the", "time", "of", "a", "positive", "result", "on", "genetic", "testing." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Decision about a cancer prevention strategy at the time of a positive result on genetic testing.
9841584
[ "##", "PATIENTS" ]
[ 0, 0 ]
## PATIENTS
9841584
[ "Carriers", "of", "a", "mutation", "for", "hereditary", "nonpolyposis", "colorectal", "cancer", "who", "were", "25", "years", "of", "age." ]
[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
Carriers of a mutation for hereditary nonpolyposis colorectal cancer who were 25 years of age.
9841584
[ "##", "INTERVENTIONS" ]
[ 0, 0 ]
## INTERVENTIONS
9841584
[ "Immediate", "prophylactic", "colectomy;", "delayed", "colectomy", "on", "the", "basis", "of", "age,", "adenoma,", "or", "diagnosis", "of", "colorectal", "cancer;", "and", "endoscopic", "surveillance.", "Prophylactic", "surgical", "options", "were", "proctocolectomy", ...
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Immediate prophylactic colectomy; delayed colectomy on the basis of age, adenoma, or diagnosis of colorectal cancer; and endoscopic surveillance. Prophylactic surgical options were proctocolectomy with ileoanal anastomosis and subtotal colectomy with ileorectal anastomosis.
9841584
[ "##", "MEASUREMENTS" ]
[ 0, 0 ]
## MEASUREMENTS
9841584
[ "Life", "expectancy", "and", "quality-adjusted", "life", "expectancy." ]
[ 0, 0, 0, 0, 0, 0 ]
Life expectancy and quality-adjusted life expectancy.
9841584
[ "##", "RESULTS" ]
[ 0, 0 ]
## RESULTS
9841584
[ "All", "risk-reduction", "strategies", "led", "to", "large", "gains", "in", "life", "expectancy", "for", "carriers", "of", "a", "mutation", "for", "hereditary", "nonpolyposis", "colorectal", "cancer,", "with", "benefits", "ranging", "from", "13.5", "years", "for",...
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All risk-reduction strategies led to large gains in life expectancy for carriers of a mutation for hereditary nonpolyposis colorectal cancer, with benefits ranging from 13.5 years for surveillance to 15.6 years for prophylactic proctocolectomy at 25 years of age compared with no intervention. The benefits of colectomy ...
9841584
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
9841584
[ "Colonoscopic", "surveillance", "is", "an", "effective", "method", "of", "reducing", "risk", "for", "cancer", "in", "carriers", "of", "a", "mutation", "for", "hereditary", "nonpolyposis", "colorectal", "cancer.", "The", "individual", "patient's", "choice", "between"...
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Colonoscopic surveillance is an effective method of reducing risk for cancer in carriers of a mutation for hereditary nonpolyposis colorectal cancer. The individual patient's choice between prophylactic surgery and surveillance is a complex decision in which personal preferences weigh heavily.
9841584
[]
[]
8431846
[ "Multiple", "polyps", "of", "esophagus,", "stomach,", "colon,", "and", "rectum", "accompanying", "rectal", "cancer", "in", "a", "patient", "with", "constitutional", "chromosomal", "inversion.", "\n\n\n", "##", "BACKGROUND" ]
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Multiple polyps of esophagus, stomach, colon, and rectum accompanying rectal cancer in a patient with constitutional chromosomal inversion. ## BACKGROUND
8431846
[ "It", "has", "been", "reported", "that", "colorectal", "carcinomas", "are", "caused", "by", "a", "multistage", "process.", "In", "patients", "with", "familial", "adenomatous", "polyposis,", "carcinoma", "of", "the", "colorectum", "frequently", "develops", "and", "...
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It has been reported that colorectal carcinomas are caused by a multistage process. In patients with familial adenomatous polyposis, carcinoma of the colorectum frequently develops and occasionally polyps develop in the upper gastrointestinal tract. Chromosomal deletion often is found for chromosomes 5, 17, and 18, on ...
8431846
[ "##", "PATIENTS", "AND", "RESULTS" ]
[ 0, 0, 0, 0 ]
## PATIENTS AND RESULTS
8431846
[ "The", "authors", "report", "the", "case", "of", "a", "48-year-old", "woman", "with", "rectal", "cancer", "accompanied", "by", "multiple", "polyps", "in", "the", "esophagus,", "stomach,", "and", "colorectum.", "Histologically,", "the", "polypoid", "lesions", "in",...
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The authors report the case of a 48-year-old woman with rectal cancer accompanied by multiple polyps in the esophagus, stomach, and colorectum. Histologically, the polypoid lesions in the esophagus, stomach, and colorectum showed a thickened mucosa, hyperplastic polyps, and mixed hyperplastic adenomatous polyps, respec...
8431846
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
8431846
[ "These", "results", "suggest", "that", "the", "development", "of", "hyperplastic", "polyps", "and", "carcinoma", "of", "the", "rectum", "results", "from", "the", "allelic", "loss", "in", "chromosome", "3p", "deletion", " ", "often", "is", "found", "for", "chro...
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These results suggest that the development of hyperplastic polyps and carcinoma of the rectum results from the allelic loss in chromosome 3p deletion often is found for chromosomes 5, 17, and 18, on which tumor suppressor genes are located. Furthermore, loss of the alleles of loci on chromosome 3 has been reporte...
8431846
[ "##", "PATIENTS", "AND", "RESULTS" ]
[ 0, 0, 0, 0 ]
## PATIENTS AND RESULTS
8431846
[ "The", "authors", "report", "the", "case", "of", "a", "48-year-old", "woman", "with", "rectal", "cancer", "accompanied", "by", "multiple", "polyps", "in", "the", "esophagus,", "stomach,", "and", "colorectum.", "Histologically,", "the", "polypoid", "lesions", "in",...
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The authors report the case of a 48-year-old woman with rectal cancer accompanied by multiple polyps in the esophagus, stomach, and colorectum. Histologically, the polypoid lesions in the esophagus, stomach, and colorectum showed a thickened mucosa, hyperplastic polyps, and mixed hyperplastic adenomatous polyps, respec...
8431846
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
8431846
[ "These", "results", "suggest", "that", "the", "development", "of", "hyperplastic", "polyps", "and", "carcinoma", "of", "the", "rectum", "results", "from", "the", "allelic", "loss", "chromosomes", "5", ",", "17", ",", "and", "18", "inversion", ".", "\n\n\n", ...
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These results suggest that the development of hyperplastic polyps and carcinoma of the rectum results from the allelic loss chromosomes 5 , 17 , and 18 inversion . ## BACKGROUND
8431846
[ "It", "has", "been", "reported", "that", "colorectal", "carcinomas", "are", "caused", "by", "a", "multistage", "process.", "In", "patients", "with", "familial", "adenomatous", "polyposis,", "carcinoma", "of", "the", "colorectum", "frequently", "develops", "and", "...
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It has been reported that colorectal carcinomas are caused by a multistage process. In patients with familial adenomatous polyposis, carcinoma of the colorectum frequently develops and occasionally polyps develop in the upper gastrointestinal tract. Chromosomal deletion often is found for chromosomes 5, 17, and 18, on ...
8431846
[ "##", "PATIENTS", "AND", "RESULTS" ]
[ 0, 0, 0, 0 ]
## PATIENTS AND RESULTS
8431846
[ "The", "authors", "report", "the", "case", "of", "a", "48-year-old", "woman", "with", "rectal", "cancer", "accompanied", "by", "multiple", "polyps", "in", "the", "esophagus,", "stomach,", "and", "colorectum.", "Histologically,", "the", "polypoid", "lesions", "in",...
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The authors report the case of a 48-year-old woman with rectal cancer accompanied by multiple polyps in the esophagus, stomach, and colorectum. Histologically, the polypoid lesions in the esophagus, stomach, and colorectum showed a thickened mucosa, hyperplastic polyps, and mixed hyperplastic adenomatous polyps, respec...
8431846
[ "##", "CONCLUSIONS" ]
[ 0, 0 ]
## CONCLUSIONS
8431846
[ "These", "results", "suggest", "that", "the", "development", "of", "hyperplastic", "polyps", "and", "carcinoma", "of", "the", "rectum", "results", "from", "the", "allelic", "loss", "in", "chromosome", "3p,", "as", "has", "been", "reported", "for", "solid", "tu...
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These results suggest that the development of hyperplastic polyps and carcinoma of the rectum results from the allelic loss in chromosome 3p, as has been reported for solid tumors at other sites.