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### Instruction: What sentiment polarity is expressed regarding the given aspect term delgocitinib in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''leo pharma presents late-breaking positive phase 3 results of delgocitinib cream in adults with moderate to severe chronic hand eczema (che) at aad 2023 - -'''### Response: The sentiment polarity expressed regarding the given aspect term delgocitinib in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term Delta 1 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''#press leo pharma presents positive results in pivotal phase 3 Delta 1 trial for #chronichandeczema patients #aad2023 read more: '''### Response: The sentiment polarity expressed regarding the given aspect term Delta 1 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term opzelura in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''after initial treatment, opzelura used on an as-needed basis was able to control symptoms of atopic dermatitis and helped patients sleep, according to a poster presented at the annual meeting. '''### Response: The sentiment polarity expressed regarding the given aspect term opzelura in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term delgocitinib in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''leo pharma presents late-breaking positive phase 3 results of delgocitinib cream in adults with moderate to severe chronic hand eczema (che) at aad 2023 '''### Response: The sentiment polarity expressed regarding the given aspect term delgocitinib in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term delgocitinib in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''message from leo pharma via ritzau: leo pharma presents late-breaking positive phase 3 results of delgocitinib cream in adults with moderate to severe chronic hand eczema (che) at aad 2023 '''### Response: The sentiment polarity expressed regarding the given aspect term delgocitinib in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term nemolizumab in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''aad 2023: late-breaking phase iii results demonstrate nemolizumab s significant impact on prurigo nodularis '''### Response: The sentiment polarity expressed regarding the given aspect term nemolizumab in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term dupilumab in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''dupilumab late-breaking data at aad show significant improvements in signs and symptoms of moderate-to-severe atopic hand and foot dermatitis '''### Response: The sentiment polarity expressed regarding the given aspect term dupilumab in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term Sahara in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''if you re at #aad2023, attend today's late-breaking research session at 10:10am, where dr. david pariser will present data from the pivotal Sahara trial which evaluated candesant's investigational sweat control patch for primary axillary hyperhidrosis. #excessivesweating '''### Response: The sentiment polarity expressed regarding the given aspect term Sahara in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term adhere in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''adhere trial on efficacy and safety of lebrikizumab in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis, from jama dermatology, free to read online during #aad2023 '''### Response: The sentiment polarity expressed regarding the given aspect term adhere in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term lebrikizumab in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''adhere trial on efficacy and safety of lebrikizumab in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis, from jama dermatology, free to read online during #aad2023 '''### Response: The sentiment polarity expressed regarding the given aspect term lebrikizumab in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term ecztend in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''leo pharma presents new adbry (tralokinumab-ldrm) data in adolescent population from ECZTRA 6 and ecztend trials at aad 2023 annual meeting '''### Response: The sentiment polarity expressed regarding the given aspect term ecztend in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term ECZTRA 6 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''leo pharma presents new adbry (tralokinumab-ldrm) data in adolescent population from ECZTRA 6 and ecztend trials at aad 2023 annual meeting '''### Response: The sentiment polarity expressed regarding the given aspect term ECZTRA 6 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term ecztend in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''message from leo pharma via ritzau: leo pharma presents new adbry (tralokinumab-ldrm) data in adolescent population from ECZTRA 6 and ecztend trials at aad 2023 annual meeting '''### Response: The sentiment polarity expressed regarding the given aspect term ecztend in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term ECZTRA 6 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''message from leo pharma via ritzau: leo pharma presents new adbry (tralokinumab-ldrm) data in adolescent population from ECZTRA 6 and ecztend trials at aad 2023 annual meeting '''### Response: The sentiment polarity expressed regarding the given aspect term ECZTRA 6 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816: NTL (med onc) noted that the main members of the MDT we need to engage with in the community are thoracic surgeons followed by pathologists and interventional pulmonologists to increase our voice in the neoadjuvant lung setting.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 Need to be able to determine who can be cured by surgery alone. What is the benefit in those patients? Do those that achieve a pCR require and benefit from adjuvant treatment? Should IO be continued in the adjuvant setting? '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 Need biomarkers for response and relapse to be able to choose patients who will derive the most benefit. Will ctDNA be helpful in this setting? '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 Surgeons and patients have a need to operate especially in the stage I and II. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816: A clear role for this regimen is the patient that is not resectable. The potential for downstaging is intriguing. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''There will be niche patients for this regiment. Post op IO was not included in the CM-816 trial but should have been. Need to know what was given adjuvant, who received XRT, which patients received adjuvant treatment and why. In the >50% PDL1, there is a good possibility of reaching a good EFS. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term KGOG3046 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR 2022. (CT010) TL at podium presented data on neoadjuvant dual IO Tremelimumab + Durvalumab + chemo in advanced-stage ovarian cancers KGOG3046. TL concluded that neoadjuvant dual IO + chemo increased clonal populations of CD8+, M1/M2 and neutrophils '''### Response: The sentiment polarity expressed regarding the given aspect term KGOG3046 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term Tremelimumab in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR 2022. (CT010) TL at podium presented data on neoadjuvant dual IO Tremelimumab + Durvalumab + chemo in advanced-stage ovarian cancers KGOG3046. TL concluded that neoadjuvant dual IO + chemo increased clonal populations of CD8+, M1/M2 and neutrophils '''### Response: The sentiment polarity expressed regarding the given aspect term Tremelimumab in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term Durvalumab in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR 2022. (CT010) TL at podium presented data on neoadjuvant dual IO Tremelimumab + Durvalumab + chemo in advanced-stage ovarian cancers KGOG3046. TL concluded that neoadjuvant dual IO + chemo increased clonal populations of CD8+, M1/M2 and neutrophils '''### Response: The sentiment polarity expressed regarding the given aspect term Durvalumab in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''The AACR 2022 presentation of CM-816 study brought attention to the TL by the pCR rate and impressive HR 0.13. The CM-816 will be definitely a practice change in Early Disease, according to her. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''TL at a large community research site stated that although they do very little surgery at his institution, the EFS data from CM-816 is compelling and he asked for the AACR 2022 and ASCO 2021 data presentations to share with the lung disease oriented group (including surgeons) at his site and other satellite sites. He noted that he would follow-up with their thoughts on the approach. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CORE-1 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CORE-1: NTL Dr. Uchio responded to question about pharmacodynamic endpoint markers to indicate combinatorial effect on the immune system between the two agents. Speaker noted that this would be the 'holy grail', but if we observe the more clinical/translational, even with PD1 markers we still treating patients without markers available, and they continue to respond. So in the case of patients who are trying to 'save their bladder', it seems treatment without biomarker is justified. '''### Response: The sentiment polarity expressed regarding the given aspect term CORE-1 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term KN057 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22: NTL Dr. Uchio responded to question about the activity of single agent pembro in this study and how it relates to synergy in the combination. TL noted that he was a part of KN057 trial with pembro single agent in this group, and that the CR rates are comparable across trials, of 41% at any time and at 12 months about 18%. We're not suppose to compare agents between trials of course, but it's at least comparable.'''### Response: The sentiment polarity expressed regarding the given aspect term KN057 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CORE-1 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22: NTL Dr. Uchio responded to question about considerations of discontinuation of CORE-1 . He noted that they were still very early on trial, and they hadn't yet had many discontinuations at all, which might be considered surprising since pembro alone has toxicity, and they haven't even seen this level of toxicity yet this early in the trial. '''### Response: The sentiment polarity expressed regarding the given aspect term CORE-1 in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term SWOG-MAP S1400I in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''In the SWOG-MAP S1400I - Patients achieving objective response had higher IL4 and LAMP3 and lower IL6 and IL8 at baseline and week 3 compared to non-responders'''### Response: The sentiment polarity expressed regarding the given aspect term SWOG-MAP S1400I in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term SWOG-MAP S1400I in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''In poster of SWOG-MAP S1400I trial there was a correlation of baseline CCL23, CSF-1, IL6 and MUC-16 and shorter survival'''### Response: The sentiment polarity expressed regarding the given aspect term SWOG-MAP S1400I in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CODEBREAK-100 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''During the discussant presentation of CODEBREAK-100, the TL stated that unlike EGFR/ALK mutations where there is little overlap of PDL1 therapy, patients with KRAS mutations may have some overlap with PDL1. He does think that there might be some benefit of using IO therapy with KRAS positive patients throughout the treatment paradigm (i.e. early stage, met, etc)'''### Response: The sentiment polarity expressed regarding the given aspect term CODEBREAK-100 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CODEBREAK-100 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''During the CODEBREAK-100 discussant, the TL stated that though KRAS inhibitors has made major advances, the overall effectiveness of KRAS inhibitors may be limited to patient factors, intrinsic biology and complex resistance mechanisms'''### Response: The sentiment polarity expressed regarding the given aspect term CODEBREAK-100 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CODEBREAK-100 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''During the discussant of CODEBREAK-100, the TL asked the question if we can give KRAS safely with IO therapy. He believes we can and sees a potential where we are combining the two agents. For example, he thinks we can give Neo-adj therapy with nivo+chemo followed by surgery and then a KRAS inhibitor or combine KN189 with a KRAS inhibitor. He does not see additional toxicities or other reasons not to combine therapy. He does agree that additional trials are warranted.'''### Response: The sentiment polarity expressed regarding the given aspect term CODEBREAK-100 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CODEBREAK-100 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''During the CODEBREAK-100 discussant presentation the TL stated that he would prioritize PDL1 therapy over KRAS therapy if the patient had high PDL1 therapy, high TMB, high TILs, and wild type STK11/KEAP1.'''### Response: The sentiment polarity expressed regarding the given aspect term CODEBREAK-100 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term talazoparib in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22: NTL Dr. de Bono emphasized that even though the pretreated mCRPC patients with a high correlation with gL OH-High status correlated with an improved response to talazoparib, the lower N and preselection of patients based on HRR11 could limit the interpretations of evident positive responses.'''### Response: The sentiment polarity expressed regarding the given aspect term talazoparib in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term talazoparib in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22: NTL Dr. de Bono responded to question about the future of talazoparib and plans moving forward, noting that ongoing Ph 3 trials will be reading out in the near future, and that he specifically thinks that this drug will serve a special special purpose in patients with germline BRCA mutations. He thinks we may be able to delay the need for castration therapy and give durable remissions, which has already been noted in a few clinical trials including his own.'''### Response: The sentiment polarity expressed regarding the given aspect term talazoparib in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] ''' b. Regional lung TL at AACR22 TLE stated that the stage IB and stage II patients in CM816 didn’t benefit as much as the stage III and that we also saw this in the IMPOWER010 trial. He also commented that the squamous patients didn’t do as well in CM816 and this is quite surprising to him.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term IMpower010 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] ''' b. Regional lung TL at AACR22 TLE stated that the stage IB and stage II patients in CM816 didn’t benefit as much as the stage III and that we also saw this in the IMPOWER010 trial. He also commented that the squamous patients didn’t do as well in CM816 and this is quite surprising to him.'''### Response: The sentiment polarity expressed regarding the given aspect term IMpower010 in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22: Additional questions surrounding the use of adjuvant treatment for patients from CM-816 and would that have additional benefit in patients even those with pCR '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''During the Q/A session, there was a question on what could be driving the differences in EFS based geography for CM-816 trial. Asia appeared to do better than Europe and NA. TL highlighted that geography was not a stratification factor and that several factors such as patient selection and type of surgery could play a role.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''TL thinks for CM-816 combining IO with is the new SOC and will almost certainly improve OS in early-stage disease. He added that neoadjuvant IO has a multiple theoretical advantages over adjuvant'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''NTL commented on the lack of guidance on what to do in patients who did not achieve a pCR. He proposed a trial to be run through ECOG where patients from CM816 regimen will be randomized to nivo/chemo or observation.'''### Response: The sentiment polarity expressed regarding the given aspect term CM816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term nivo in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''NTL commented on the lack of guidance on what to do in patients who did not achieve a pCR. He proposed a trial to be run through ECOG where patients from CM816 regimen will be randomized to nivo/chemo or observation.'''### Response: The sentiment polarity expressed regarding the given aspect term nivo in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term 816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''TL wondered what to do when you find out patients in 816 also carried driver mutation. Did those patients benefit from CM816? No data has been shared.'''### Response: The sentiment polarity expressed regarding the given aspect term 816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''TL wondered what to do when you find out patients in 816 also carried driver mutation. Did those patients benefit from CM816? No data has been shared.'''### Response: The sentiment polarity expressed regarding the given aspect term CM816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''NTL highlighted the CM-816 EFS benefit in PDL1 positive there was a difference of 25% at years 2 and 3. NTL highlighted the data was being clinical significant.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term 816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''Prominent lung TL, I really think that the 816 trial readout was the best of #AACR22 and while pembro was looking good for a while, this really brings nivo back to the forefront of people's minds'''### Response: The sentiment polarity expressed regarding the given aspect term 816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term pembro in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''Prominent lung TL, I really think that the 816 trial readout was the best of #AACR22 and while pembro was looking good for a while, this really brings nivo back to the forefront of people's minds'''### Response: The sentiment polarity expressed regarding the given aspect term pembro in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term nivo in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''Prominent lung TL, I really think that the 816 trial readout was the best of #AACR22 and while pembro was looking good for a while, this really brings nivo back to the forefront of people's minds'''### Response: The sentiment polarity expressed regarding the given aspect term nivo in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22: During CT012 presentation of CM816 EFS data, NTL summarized data by noting that there was no increased toxicity or surgical complications with the addition of nivo to chemo and there was a statistically significant and clinically meaningful improvement in EFS with nivo + chemo vs chemo.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term nivo in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22: During CT012 presentation of CM816 EFS data, NTL summarized data by noting that there was no increased toxicity or surgical complications with the addition of nivo to chemo and there was a statistically significant and clinically meaningful improvement in EFS with nivo + chemo vs chemo.'''### Response: The sentiment polarity expressed regarding the given aspect term nivo in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''TL commented that the cm-816 data showed a very solid HR and was very reassuring. TL mentioned that their current SOC for stage 3 As outside of trials is upfront Sx followed by adjuvant where the EFS would have looked different however (at 5 Yrs. adjuvant there is only 10-12% benefit) so this data so definitely shifting that curve despite still having to mature more.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''TL commented that EFS is definitely a surrogate for OS at the moment and has to be a surrogate for all neoadjuvant trials like cm-816. It is not practical for it not to be in Neoadjuvant settings as you cannot wait always for OS to come through. It takes a long time and the field changes whilst you wait.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''NTL shared that he prefers CM-816 survivals as a metric of success over median OS especially IO therapy because of the MOA of these agents'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''NTL shared that in CM816, there was an EFS benefit in patients who achieved cPR and those who did not. This is the first time EFS benefit has been seen from patients with pCR and those without in a phase 3 randomized trial in resectable NSCLC.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term Nivochemo in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''Despite OS not reaching significance, NTL highlighted the fact that the difference in OS between patients on Nivochemo at 24 months was 12% and that this is clinically meaningful.'''### Response: The sentiment polarity expressed regarding the given aspect term Nivochemo in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term Nivochemo in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''NTL highlighted that the benefit of EFS in stage 1B and 2A patients did not reach statistical significance but is trending in favor of those treated with Nivochemo. That is because it is still maturing and it reflects the better prognosis in these patients.'''### Response: The sentiment polarity expressed regarding the given aspect term Nivochemo in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22: During CT012 presentation of the CM816 EFS data, NTL stated that EFS was consistently improved across the majority of subgroups even though it was not powered to detect differences. In regard to EFS by stage, he noted that in patients with stage Ib-II disease these data are not mature enough to see the full benefit yet as these patients have a better prognosis- longer follow up may show additional benefit of nivo + chemo in this subgroup.'''### Response: The sentiment polarity expressed regarding the given aspect term CM816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term NADIM in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''Neoadjuvant ICI, AACR22: NTL began review of neoadjuvant presentation by showing remarkable benefit of just brief exposure to anti-PD1 on depth of path response with nivo mono (Forde et al) or atezo mono (LCMC3), emphasizing 3-yr OS ~80% similar from LCMC3 and NADIM trials in stage III patients - more than doubling prior expectations, pointing out no adjuvant IO was provided. Very impressive'''### Response: The sentiment polarity expressed regarding the given aspect term NADIM in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM816, AACR22: NTL from the podium emphasizes that 'thoracic surgery is not good psychotherapy' and we need to change the mindset with surgeons and patients regarding that actual medical urgency vs a 'psychological' urgency to operate immediately in resectable patients'''### Response: The sentiment polarity expressed regarding the given aspect term CM816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term IMPOWER010 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''Biomarkers in perioperative setting NSCLC, AACR22 - NTL from podium commenting on ctDNA analysis from IMPOWER010 indicating that benefit magnitude of adjuvant atezo better in high risk patients, however sensitivity is remains an issue. Notes importance of neoadjuvant regimens to be tolerable enough to be applied to those who may be cured by surgery alone, and importance of biomarkers in light of cost of these therapies '''### Response: The sentiment polarity expressed regarding the given aspect term IMPOWER010 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term PACIFIC in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''PACIFIC, AACR22: NTL discussing from the podium - need to validate whether timing matters (between CRT/RT and ICI), noting trend for benefit in analysis of patients who started durva within 14 days of CRT - is there a locally inflamed environment that is priming the immune system?'''### Response: The sentiment polarity expressed regarding the given aspect term PACIFIC in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term durva in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''PACIFIC, AACR22: NTL discussing from the podium - need to validate whether timing matters (between CRT/RT and ICI), noting trend for benefit in analysis of patients who started durva within 14 days of CRT - is there a locally inflamed environment that is priming the immune system?'''### Response: The sentiment polarity expressed regarding the given aspect term durva in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term KN-091 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''KN091 NTL highlighted significant toxicity imbalance although still lower PD rate for pembro despite 14% of patients not receiving any adjuvant chemo. Regarding safety data from KN091 that ~2% AE's leading to death is difficult to accept for patients who might otherwise be cured and magnitude of benefit is disappointing '''### Response: The sentiment polarity expressed regarding the given aspect term KN-091 in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term IMPOWER010 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''IMPOWER010, AACR22: NTL said that DFS and OS KM curves hint significant OS improvement will be achieved, but highlights subgroup data of PD-L1 ? 50% driving most benefit, lack of benefit in driver mutations so still important to perform genomic testing early, despite doubt that TKIs will are curative in any setting (as opposed to IO)'''### Response: The sentiment polarity expressed regarding the given aspect term IMPOWER010 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''While discussing CM816 data from AACR with a community oncologist with a limited contact with thoracic surgeons TL commented about this being intriguing data but main question is the control arm for this study is not typical standard of care (at least in the respective region). So, TL thought there might be some issues around practical implementation and was wondering whether the value remains unclear.'''### Response: The sentiment polarity expressed regarding the given aspect term CM816 in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : • 2y OS of 83% is promising • HR is on track • Taken together, the data is practice changing • He expected 30% OS benefit and what this data is showing is around 40% • Looks likes starting to plateau'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''An academic community medical oncologist very experienced with IO across different indications was very impressed with CM-816 data presented at AACR. TL mentioned that patient selection remains a challenge and likes to see a study, maybe even phase 2 where stage IB and II are compared so that we can see which patient drives the most benefit.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : 2/3 of the patients are stage III. In the real world, they treat most stage IIIs with chemoradiation followed by durvalumab. ie the comparator for many operable stage III patients is actually PACIFIC. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term durvalumab in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : 2/3 of the patients are stage III. In the real world, they treat most stage IIIs with chemoradiation followed by durvalumab. ie the comparator for many operable stage III patients is actually PACIFIC. '''### Response: The sentiment polarity expressed regarding the given aspect term durvalumab in the given tweet is positve |
### Instruction: What sentiment polarity is expressed regarding the given aspect term PACIFIC in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : 2/3 of the patients are stage III. In the real world, they treat most stage IIIs with chemoradiation followed by durvalumab. ie the comparator for many operable stage III patients is actually PACIFIC. '''### Response: The sentiment polarity expressed regarding the given aspect term PACIFIC in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''An academic community medical oncologist very experienced with IO across different indications was very impressed with CM-816 data presented at AACR. TL was surprised that majority of the patients in CM-816 were stage IIIA and mentioned at their institution majority of stage IIIA get delineated by PET imaging at and are typically unresectable and sent for Chemo-RT followed by consolidated Durvalumab. But TL also believed that their surgeons would be keen about the data and the increased possibility of operating stage IIIA upfront. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term Durvalumab in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''An academic community medical oncologist very experienced with IO across different indications was very impressed with CM-816 data presented at AACR. TL was surprised that majority of the patients in CM-816 were stage IIIA and mentioned at their institution majority of stage IIIA get delineated by PET imaging at and are typically unresectable and sent for Chemo-RT followed by consolidated Durvalumab. But TL also believed that their surgeons would be keen about the data and the increased possibility of operating stage IIIA upfront. '''### Response: The sentiment polarity expressed regarding the given aspect term Durvalumab in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : The Tx surgeon expressed that benefit in surgery without significant toxicity or complication are not observed in patients with NSCLC with others treatments, this is amazing together with the long term benefit of patients.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816: Discussant noted limited # patients stage IB and II, making interpretations regarding EFS differences difficult '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-649 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-649 bio makers: patients with low CPS scores had benefit as well, particularly if they had low angiogenesis GES'''### Response: The sentiment polarity expressed regarding the given aspect term CM-649 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : The TL expressed that this study is excellent, a new paradigm of treatment for patients with NSCLC. The EFS data by patients subgroups is valuable, the OS is impressive even when data is not madure.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816: Interesting that there were such EFS differences in the greography subgroup. Possible surgical approach differences were noted as a reason- but more analysis is necessary '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 subsequent therapy analysis requested by NTL TL to understand which patients received ADJ chemo Rad. May help answer if there was added benefit, esp. in patients who had a pCR '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR 2022. Iovance Representative told me that this company has been discussing utilizing their Tumor Infiltrating Lymphocytes (TIL) manufacturing process in NSCLC in either the neoadjuvant or adjuvant setting. Since the process requires >1.5 cm tumor to make the TIL, the resected tumor is either going to Pathology or disposal and this would be an ideal time to collect the necessary tissue. The Rep stated the TL at MSK have a feeling, without supporting data, that the TIL collected after priming with CM-816 would be superior than TIL infused in the adjuvant setting'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816: After discussing the recent AACR dataset, the TL replied This data changes everything, now there's no reason not to do this!'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22 CM-816 EFS Discussion – at the podium. Question from the audience: Can you expand on the subgroup HR differences based on the geography where Asia seems to outperform North American and Europe.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22 CM-816 EFS Discussion – at the podium. Question from the audience: Should patients with no pCR have additional adjuvant therapy? '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22 CM-816 discussant at the podium – stated his take home message – combining IO and surgery, is the new standard of care and will almost certainly improve overall survival in early stage disease- for the first time, in decades in my entire career.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22 CM-816 EFS Discussant at the podium – stated we are at an age where peri-operative therapies are moving us one step closer to curing this disease [NSCLC].'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22 CM-816 EFS Discussant at the podium – when discussing between neoadjuvant between adjuvant IO. NTL stated that he looks at landmark survival in advanced disease as a metric of success. The treatments need to be safe enough the potentially surgically curable patient population. NTL believes neoadj IO meets all the criteria. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''AACR22 CM-816 discussant at the podium stated that the PD-L1 negative subset might benefit from additional chemo IO. NTL suggested an ECOG study to due CM816 regimen and then for non pCR patients randomize to chemo+IO vs. no additional adjuvant regimen. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : nivo+CT neoadj after AACR presentation: nivo+CT will be the new SOC'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : Key takeaway for surgeons: IIIA EFS data means that surgeons can take back the operable IIIA patients (ie: operate on them rather than have the rad oncs to give them PACIFIC regimen)'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term PACIFIC in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : Key takeaway for surgeons: IIIA EFS data means that surgeons can take back the operable IIIA patients (ie: operate on them rather than have the rad oncs to give them PACIFIC regimen)'''### Response: The sentiment polarity expressed regarding the given aspect term PACIFIC in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : Is there a breakdown of histology and PD-L1? Are there more Pd-L1 negatives in the SQ group? '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : He does not expect to see separation of EFS curves in stage Ib/II until 3y. He expects OS will be significant at next analysis'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : He would give neoadjuvant IO+chemo to stage IIIA with unknown PD-L1 or Pd-L1>=1% based on this data.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''Respiratory physicians need to see this data because when they upstage a patient after EBUS to stage IIIA, they need to send them back to the surgeon.Rad oncs need to see this data so that operable IIIA can get CM-816 and surgery rather than PACIFIC.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term PACIFIC in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''Respiratory physicians need to see this data because when they upstage a patient after EBUS to stage IIIA, they need to send them back to the surgeon.Rad oncs need to see this data so that operable IIIA can get CM-816 and surgery rather than PACIFIC.'''### Response: The sentiment polarity expressed regarding the given aspect term PACIFIC in the given tweet is negative |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''CM-816 : During a remote interaction, TL has mentioned about the recent publication at NEJM and presentation at AACR 2022. TL think that this is possibly practice changing but the interim overall survival analysis did not cross statistical significance. It is still important to look at OS follow up and subgroup analysis. He thinks that it is important to increase awareness among surgeons and chest physicians. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''When discussing CM-816 data from AACR TL compared the results from this study with the 2 adjuvant trials. TL believes that adjuvant IO would be needed but for now, we do not know who should receive it as the 2 adjuvant trials showed a different subgroup of patients who benefited from adjuvant IO. The Roche trial was mainly the PDL-1 high while the Merck trial is the PDL-1 <50%. The med onc mentioned that most international TLs are still puzzled and cant explain the differences in these results. '''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is neutral |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''While discussing CM-816 data from AACRC TL confidently commented believing in FES translating into longer term OS with data maturing and the 95% CIs tightening. TL also believes that complete PR will predict OS.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''While discussing CM-816 data from AACR with this thoracic surgeon TL expressed strong belief in complete PR predicting OS and DFS translating into long term OS with a longer follow-up. However, the TL mentioned the question remains as to whether these outcomes will bear true for specific molecular alterations including but not limited to EGFR, ALK, ROS1, ret, etc!'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |
### Instruction: What sentiment polarity is expressed regarding the given aspect term CM-816 in the given tweet delimited by triple quotes? Answer from the options [\"positive\", \"negative\", \"neutral\"] '''On CM-816 AACR data release:TL said she was having a lot of hope in this trial and she is not disappointed by the results. TL said, of course, the OS data are to mature, but she think the results of pCR and EFS justify to consider nivo+chemo as SOC. TL stated that she need to take the time to have a deeper look on population and subgroup. TL would like to get access by BMS to this option. TL think there is a need for physicians to get prepared to use nivo+CT in this setting. TL explains that neoadjuvant treament is rarely use in her region and that there will be a need for mentality changes, ways of working to be reviewed.'''### Response: The sentiment polarity expressed regarding the given aspect term CM-816 in the given tweet is positive |