Module Expr Str ImportFrom alias ImportFrom alias ImportFrom alias Expr Call NameLoad Expr Call NameLoad Str ListLoad Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad Str ListLoad Str Str Dict Str ListLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad Str ListLoad Str Str Str Dict Str Str ListLoad Str Str ListLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad Str ListLoad Str Str Dict Str Str ListLoad Str Str ListLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad NameLoad Str Str Expr Call NameLoad Str ListLoad Str Expr Call NameLoad NameLoad Str Expr Call NameLoad Str ListLoad Str Expr Call NameLoad NameLoad Str Assign NameStore Num Assign NameStore Num Assign NameStore Num Assign NameStore Num Assign NameStore ListLoad NameLoad NameLoad Assign NameStore BinOpAdd NameLoad ListLoad NameLoad Assign NameStore BinOpAdd NameLoad ListLoad NameLoad FunctionDef arguments args NameParam NameParam NameParam NameParam defaults body Expr Str Assign NameStore Call NameLoad If CompareIn Str AttributeLoad AttributeLoad NameLoad attr attr body Assign NameStore Call NameLoad keyword NameLoad Assign NameStore Call NameLoad NameLoad Str NameLoad NameLoad NameLoad Str Str NameLoad AugAssignBitOr NameStore Call NameLoad NameLoad Str NameLoad NameLoad NameLoad Str Str NameLoad Return NameLoad decorator_list FunctionDef arguments args NameParam NameParam NameParam NameParam NameParam defaults body Expr Str Assign NameStore Call NameLoad NameLoad NameLoad Call NameLoad Dict NameLoad Str NameLoad AugAssignBitOr NameStore Call NameLoad NameLoad NameLoad Call NameLoad Dict NameLoad Str NameLoad Return NameLoad decorator_list Expr Call NameLoad NameLoad NameLoad NameLoad Str Expr Call NameLoad Call NameLoad keyword Str NameLoad NameLoad Str Str Expr Call NameLoad Call NameLoad keyword Str keyword Str NameLoad NameLoad Str Str Expr Call NameLoad Call NameLoad keyword NameLoad Call NameLoad Str Num Expr Call NameLoad Call NameLoad keyword Str keyword NameLoad Call NameLoad Str Num Expr Call NameLoad Call NameLoad keyword Str keyword Str keyword NameLoad Call NameLoad Str Num Expr Call NameLoad Call NameLoad keyword Str keyword Str Call NameLoad Str Num Expr Call NameLoad Call NameLoad keyword NameLoad Call NameLoad Str Num Expr Call NameLoad Call NameLoad keyword NameLoad Call NameLoad Str Num Expr Call NameLoad Str Call NameLoad keyword Str keyword Str Expr Call NameLoad Str Call NameLoad keyword Str keyword Str If CompareEq NameLoad Str body Expr Call NameLoad NameLoad Str NameLoad Expr Call NameLoad Str
N/A N/A Adapted from a portion of the model published in:

Input-output behavior of ErbB signaling pathways as revealed by a mass action
model trained against dynamic data. William W Chen, Birgit Schoeberl, Paul J
Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger & Peter K
Sorger. Mol Syst Biol. 2009;5:239. Epub 2009 Jan 20. doi:10.1038/msb.2008.74

http://www.nature.com/msb/journal/v5/n1/full/msb200874.html

Implemented by: Jeremy Muhlich
 __future__ print_function pysb * pysb.macros catalyze_state N/A N/A Model N/A N/A Monomer Ras N/A k N/A N/A Annotation Ras http://identifiers.org/uniprot/P01116 hasPart N/A N/A Annotation Ras http://identifiers.org/uniprot/P01112 hasPart N/A N/A Annotation Ras http://identifiers.org/uniprot/P01111 hasPart N/A N/A Monomer Raf N/A s k N/A s N/A u p N/A N/A Annotation Raf http://identifiers.org/uniprot/P15056 hasPart N/A N/A Annotation Raf http://identifiers.org/uniprot/P04049 hasPart N/A N/A Annotation Raf http://identifiers.org/uniprot/P10398 hasPart N/A N/A Monomer MEK N/A s218 s222 k N/A s218 s222 N/A u p N/A u p N/A N/A Annotation MEK http://identifiers.org/uniprot/Q02750 hasPart N/A N/A Annotation MEK http://identifiers.org/uniprot/P36507 hasPart N/A N/A Monomer ERK N/A t185 y187 N/A t185 y187 N/A u p N/A u p N/A N/A Annotation ERK http://identifiers.org/uniprot/P27361 hasPart N/A N/A Annotation ERK http://identifiers.org/uniprot/P28482 hasPart N/A N/A Monomer PP2A N/A ppt N/A N/A Annotation PP2A http://identifiers.org/mesh/24544 N/A N/A Monomer MKP N/A ppt N/A N/A Annotation MKP http://identifiers.org/mesh/24536 N/A kf_bind 1e-05 N/A kr_bind 0.1 N/A kcat_phos 0.1 N/A kcat_dephos 0.003 N/A klist_bind N/A kf_bind kr_bind N/A klist_phos N/A klist_bind N/A kcat_phos N/A klist_dephos N/A klist_bind N/A kcat_dephos mapk_single N/A N/A kinase pptase substrate site N/A N/A N/A Kinase phos/dephosphorylation. N/A ppt_substrate N/A substrate N/A N/A k N/A N/A ppt_substrate monomer sites N/A N/A ppt_substrate N/A ppt_substrate k None N/A components N/A catalyze_state kinase k substrate site site u p klist_phos N/A components N/A catalyze_state pptase ppt ppt_substrate site site p u klist_dephos N/A components N/A mapk_double N/A N/A kinase pptase substrate site1 site2 N/A N/A N/A Distributive + ordered double kinase phos/dephosphorylation. N/A components N/A mapk_single kinase pptase N/A substrate N/A site2 u site1 N/A components N/A mapk_single kinase pptase N/A substrate N/A site1 p site2 N/A components N/A N/A N/A mapk_single Ras PP2A Raf s N/A N/A mapk_double N/A Raf s p PP2A MEK s218 s222 N/A N/A mapk_double N/A MEK s218 p s222 p MKP ERK t185 y187 N/A N/A Initial N/A Ras k None N/A Parameter Ras_0 60000.0 N/A N/A Initial N/A Raf s u k None N/A Parameter Raf_0 70000.0 N/A N/A Initial N/A MEK s218 u s222 u k None N/A Parameter MEK_0 3000000.0 N/A N/A Initial N/A ERK t185 u y187 u N/A Parameter ERK_0 700000.0 N/A N/A Initial N/A PP2A ppt None N/A Parameter PP2A_0 200000.0 N/A N/A Initial N/A MKP ppt None N/A Parameter MKP_0 17000.0 N/A N/A Observable ppMEK N/A MEK s218 p s222 p N/A N/A Observable ppERK N/A ERK t185 p y187 p N/A N/A __name__ __main__ N/A N/A N/A print __doc__ model N/A N/A print 
NOTE: This model code is designed to be imported and programatically
manipulated, not executed directly. The above output is merely a
diagnostic aid.