               S                       NM                  M         0 y 0 m                    N                              \+                 0                  0                    0                         \+                          \+                        \+                   0   00               S                       NM                  F         0 y                        N                              \+                 0                  0                    \+                        \+                          0                         0                    0   00               S                       NM                  F         0 m                        LD                             \+                 \+                 0                    \+                        \+                          0                         0                    0   00               S                       FS                  M         0 y                        N                              \+                 0                  0                    0                         \+                          \+                        0                    0   00               F                       NM                  M         0 y 0 m                    LD                             \+                 0                  0                    0                         \+                          \+                        0                    0   00               S                       FS                  M         0 m                        LD                             \+                 \+                 0                    0                         \+                          \+                        \+                   \+   00               S                       FS                  M         0 y                        N                              \+                 0                  0                    \+                        \+                          0                         \+                   0  N: normal or no seizure, LD: learning disorder, MR: metal retardation, NA: not available.  ######   Clinical data of patients with *TSC0*mutations    **Family no**.   **Familial/Sporadic**   **Mutation type**   **Sex**   **Onset age of seizure**   **Intellectual performance**   **Brain tubers**   **Renal tumors**   **Hepatic tumors**   **Cardiac rhabdomyoma**   **Hypomelanotic macules**   **Facial angiofibroma**   **Shagreen patch**   **Ungual fibroma**   ---------------- ----------------------- ------------------- --------- -------------------------- ------------------------------ ------------------ ------------------ -------------------- ------------------------- --------------------------- ------------------------- -------------------- --------------------   0                S                       MM                  M         00 m                       N                              \+                 \+                 0                    0                         \+                          \+                        \+                   0   0                S                       MM                  F         0 y                        N                              \+                 NA                 NA                   0                         \+                          \+                        0                    0   0                S                       FS                  M         0 m                        LD                             \+                 0                  0                    \+                        \+                          0                         0                    0   0                S                       MM                  M         0 m                        MR                             NA                 NA                 NA                   NA                        \+                          \+                        0                    0   0                S                       S                   F         0 m                        LD                             \+                 \+                 0                    0                         \+                          \+                        \+                   0   0                S                       FS                  M         0 y                        LD                             \+                 0                  0                    0                         \+                          \+                        \+                   0   00               S                       FS                  F         0 m                        LD                             \+                 0                  0                    \+                        \+                          \+                        0                    0   00               F                       FS                  F         0 m                        LD                             \+                 \+                 0                    \+                        0                           \+                        \+                   0   00               S                       NM                  M         00 m                       N                              \+                 \+                 0                    NA                        \+                          \+                        \+                   0   00               S                       FS                  F         0 m                        MR                             \+                 NA                 NA                   \+                        0                           0                         0                    0   00               F                       MM                  F         0 m                        MR                             \+                 0                  0                    0                         \+                          0                         0                    0   00               S                       FS                  M         0 y                        N                              \+                 \+                 0                    NA                        \+                          \+                        \+                   \+   00               S                       FS                  F         0 m                        LD                             \+                 NA                 NA                   NA                        \+                          \+                        \+                   0   00               S                       NM                  M         0 m                        MR                             \+                 \+                 0                    NA                        \+                          0                         0                    0   00               S                       NM                  M         0 y 0 m                    N                              \+                 \+                 0                    0                         \+                          \+                        0                    0   00               F                       FS                  F         0 y                        N                              \+                 \+                 0                    0                         \+                          \+                        \+                   \+   00               F                       FS                  M         0 y                        LD                             NA                 NA                 NA                   NA                        \+                          \+                        \+                   0   00               S                       NM                  F         0 m                        MR                             \+                 NA                 NA                   NA                        \+                          0                         0                    0   00               S                       FS                  M         0 m                        LD                             \+                 0                  NA                   0                         \+                          \+                        \+                   0   00               S                       FS                  F         0 m                        LD                             \+                 \+                 0                    0                         \+                          \+                        \+                   0   00               S                       NM                  M         0 y                        MR                             \+                 \+                 0                    0                         \+                          \+                        0                    0   00               S                       NM                  M         0 m                        LD                             \+                 NA                 NA                   NA                        \+                          \+                        \+                   0   00               S                       MM                  F         0 m                        MR                             \+                 0                  NA                   0                         \+                          0                         \+                   0   00               S                       FS                  F         0 y                        MR                             \+                 \+                 0                    0                         \+                          \+                        0                    0   00               S                       NM                  M         0 m                        N                              \+                 \+                 \+                   0                         \+                          \+                        0                    0   00               S                       FS                  F         0 m                        N                              \+                 \+                 \+                   0                         \+                          \+                        \+                   \+   00               S                       MM                  F         0 y                        N                              \+                 \+                 0                    0                         \+                          0                         \+                   0   00               S                       NM                  M         0 y                        MR                             \+                 \+                 0                    \+                        \+                          \+                        \+                   0   00               F                       MM                  M         0 m                        MR                             \+                 0                  0                    \+                        \+                          \+                        \+                   0   00               F                       FS                  F         0 m                        MR                             \+                 NA                 NA                   NA                        \+                          \+                        \+                   0   00               F                       MM                  M         0 y                        N                              0                  \+                 \+                   NA                        \+                          \+                        \+                   \+   00               S                       FS                  F         0 m                        N                              \+                 0                  0                    \+                        \+                          0                         0                    0   00               S                       FS                  F         0 m                        MR                             \+                 \+                 0                    0                         \+                          \+                        \+                   0   00               S                       MM                  M         0 m                        MR                             \+                 NA                 NA                   NA                        \+                          \+                        \+                   0   00               S                       FS                  M         0 y                        MR                             \+                 \+                 0                    0                         \+                          \+                        \+                   0   00               F                       MM                  F         0 y                        N                              \+                 \+                 \+                   0                         \+                          \+                        \+                   \+   00               S                       NM                  F         0 m                        MR                             \+                 0                  0                    0                         \+                          \+                        \+                   0   00               S                       S                   F         0 m                        MR                             \+                 \+                 0                    0                         \+                          \+                        0                    0   00               S                       NM                  M         0 m                        N                              \+                 0                  0                    0                         \+                          0                         0                    0   00               S                       S                   F         0 m                        MR                             \+                 0                  0                    \+                        \+                          \+                        0                    0   00               S                       S                   F         0