. Bar graph indicates the percentage of apoptotic cells. Percentage of apoptotic cells was evaluated by Annexin V positive and PI negative (AV+/PI-, white) and Annexin V and PI double positive (AV+/PI+, black) apoptotic cells. All data were expressed as mean ± SEM of three independent experiments. \*p\<0.00 and \*\*p\<0.00 compared with control; ^\#^ p\<0.00 compared with MML-treated group.](pone.0000000.g000){#pone-0000000-g000}  MML induces autophagy through p00-mediated AMPK/mTOR pathway {#s0f} ------------------------------------------------------------  It is known that 