://www.Vecteezy.com) with permission.](fimmu-00-00000-g0000){#F0}  Author Contributions {#s0} ====================  All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.  Conflict of Interest --------------------  The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.  **Funding.** This work was supported by 