 with varied socio-demographic and clinical characteristics, suggesting it has high utility and acceptability in an Italian clinical setting. Statistical analyses showed that READY was not more efficacious than relaxation. In contrast, qualitative data indicated that READY was viewed by participants as superior to relaxation; a finding that converged with four non-significant statistical trends supporting the efficacy of READY. Consistent with the ACT psychological flexibility framework, the qualitative data indicated that participants' perceived improvements in resilience and QoL were due to the acquisition of skills related to the six core ACT processes.  The Steering Committee and an international expert panel (four persons) jointly discussed the study findings in two dedicated meetings (00 and 00 January 0000) and outlined the multi-centre RCT evaluation of the Italian READY for MS program. It was a structured discussion, using a "PICO" (Population, Intervention, Comparator, Outcomes) format \[00\]. The eligibility criteria of the pilot RCT, as well as the READY program were deemed adequate by the panel (Population and Intervention). To limit possible involuntary contaminations, 