.  Conflict of Interest {#s0} ====================  The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.  Supplementary Material {#s00} ======================  The Supplementary Material for this article can be found online at: <https://www.frontiersin.org/articles/00.0000/fphar.0000.00000/full#supplementary-material>  ######   Click here for additional data file.  ######   Click here for additional data file.  [^0]: Edited by: Chris