y.  Availability of data and materials {#FPar0} ==================================  The datasets used and analysed during the current study are available from the corresponding author upon reasonable request.  Consent for publication {#FPar0} =======================  Not applicable.  Ethics approval and consent to participate {#FPar0} ==========================================  The participants provided written informed consent to take part in the study. Our study received ethical approval by the Institutional Review Board of the Medical Faculty of the Heinrich-Heine University of Düsseldorf (no. 0000R).  Funding {#FPar0} =======  This work was funded by 