 based on the reported quantitative evaluation of all RNA hexamers as potential ESR (Ke et al. [0000](#mgg0000-bib-0000){ref-type="ref"}), which allows the calculation of total ESRseq score changes (ΔtESRseq) for each variant, as previously described (Di Giacomo et al. [0000](#mgg0000-bib-0000){ref-type="ref"}; Soukarieh et al. [0000](#mgg0000-bib-0000){ref-type="ref"}).  