 from Eqs [00](#pone.0000000.e000){ref-type="disp-formula"}, [00](#pone.0000000.e000){ref-type="disp-formula"}, [00](#pone.0000000.e000){ref-type="disp-formula"} and [00](#pone.0000000.e000){ref-type="disp-formula"} for the 