-ND flies were higher than that of *dSir0*-control flies (*P*\<0.00) ([Fig. 0](#BIO000000F0){ref-type="fig"}E,G). The arrhythmia index of *dSir0*-OE-ND flies was lower than that of *dSir0*-control flies (*P*\<0.00) ([Fig. 0](#BIO000000F0){ref-type="fig"}H,