](#pone.0000000.g000){ref-type="fig"}). On the other hand, the rate of change in the N/T ratio increased over time and reached a significant increase at 0 and 0 years after SLT ([Fig 0A](#pone.0000000.g000){ref-type="fig"}). The rate of change in the N/T ratio in each case is presented in [Fig 0B](#pone.0000000.g000){ref-type="fig"}. Seven of 0 cases that we were able to follow the lung volume and PFT available every year showed the increase of 