 in patients with early and established RA at month 00. \*p\<0.00; \*\*p\<0.00; \*\*\*p\<0.000; \*\*\*\*p\<0.0000 vs MTX within disease duration category. Early and established RA are defined as disease duration \<0 and ≥0 year, respectively. ACR, American College of Rheumatology response criteria; DAS00-0(ESR), Disease Activity Score in 00 joints, erythrocyte sedimentation rate; HAQ-DI, Health Assessment Questionnaire-Disability Index; LS, least squares; MTX, methotrexate; RA, rheumatoid arthritis