nts.  [Supplementary Information](#sup0){ref-type="supplementary-material"} accompanies this paper on British Journal of Cancer website (http://www.nature.com/bjc)  This work is published under the standard license to publish agreement. After 00 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 0.0 Unported License.  Supplementary Material {#sup0} ======================  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ######   Click here for additional data file.  ![**