  0\. Mice sham irradiated with 000 fractions die significantly ealier than those mice with fewer fractions. Does the truly irradiated group have a similar finding?  0\. The genetic and immune background of B0CF0 mice should be discussed in the discussion.  0\. Fig0,0 and 0, the statistic significance should be caculated and labeled both in the results part and figures.  0\. In Fig 0, It seems there was a sinificant difference between two groups in tumors(excluding lung), CDU and lymphoma. And possibilities that CDU may affect the death caused by tumors should be discussed.  0\. Table 0 legend, Parameter estimates, hazard ratios with 00% confidence interval, and p-values for main  Cox Proportional Hazards model in Fig 0D. It should be Fig0D ? or Fig 0D?  0\. since the sex difference is shared in common by control and irradiation, the sex role in death affected by irradiation should be adjusted.  0\. In Line 000, the B0C0F0 mice strain used at IES was genetically similar to the B0C0F0 mice used in the Janus experiments. It should be B0CF0 or B0C0F0 in the Janus?  0\. The indicated clinical impact and potential use of the findings in this study are recommended to be discussed.  0\. Its not clear whether neutron irradiation treatment is excluded or not.  00\. all figures in the integrated muanscript is too vague to see. The orignal figures in tiff format are good.  \*\*\*\*\*\*\*\*\*\*  0\. PLOS authors have the option to publish the peer review history of their article ([what does this mean?](https://journals.plos.org/plosone/s/editorial-and-peer-review-process#loc-peer-review-history)). If published, this will include your full peer review and any attached files.  If you choose "no", your identity will remain anonymous but your review may still be made public.  **Do you want your identity to be public for this peer review?** For information about this choice, including consent withdrawal, please see our [Privacy Policy](https://www.plos.org/privacy-policy).  Reviewer \#0: No  Reviewer \#0: No  \[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link \"View Attachments\". If this link does not appear, there are no attachment files to be viewed.\]  While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, <https://pacev0.apexcovantage.com/>. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email us at <figures@plos.org>. Please note that Supporting Information files do not need this step.  00.0000/journal.pone.0000000.r000  Author response to Decision Letter 0  00 Jun 0000  