 in response to increasing concentrations of FFP (a), rFVIIa (b), PCC (c) and inhibition of TFPI (d). Horizontal black lines represent the median, boxes the interquartile range, whiskers the range; asterisks and circles represent outliers. FFP, fresh frozen plasma; PCC, prothrombin complex concentrate; rFVIIa, recombinant factor VIIa; TFPI, tissue factor pathway inhibitor.](blcof-00-000-g000){#F0}  ![