000 genes) gene sets by Fisher\'s exact test; circle size and colour indicate the odds ratio of all significant overlaps (Bonferroni-adjusted *P* value \<0.00); overlaid text displays the adjusted *P* value for each enrichment. (**d**) Shifts in the distribution of sex-differential expression direction for genes in each ASD risk or ASD expression sets, and (**f**) neural cell type markers. Blue and pink bars display the proportions of each gene set that have higher expression in males (FD\>0) or females (FD\<0); whiskers note 00% confidence intervals; horizontal black lines note the proportion of male- and female-higher genes in the corresponding background gene set. Overlaid text displays significant Bonferroni-adjusted *P* values from the binomial test. chr, chromosome; disr., disrupting; expr., expression; F, female; M, male.](ncomms00000-f0){#f0}