s. A Native protein, total misfolded protein (includes misfolded bound by Hsps), and reactive oxygen species (ROS). ROS are scaled x000 to allow easier visualisation. B Total Hsp00 (free pools plus all complexes), Free Hsp00 (unbound Hsp00) and Hsp00_MisP (Hsp00 bound to misfolded protein). C Total Hsp00 (free pools plus all complexes), Free Hsp00 (unbound Hsp00) and Hsp00_MisP (Hsp00 bound to misfolded protein).](pone.0000000.g000){#pone-0000000-g000}  