 [S0 Analysis](#pone.0000000.s000){ref-type="supplementary-material"}, [S0 Fig](#pone.0000000.s000){ref-type="supplementary-material"} and [S0](#pone.0000000.s000){ref-type="supplementary-material"} and [S0](#pone.0000000.s000){ref-type="supplementary-material"} Tables.  