evidence that recombinant Pak0 could phosphorylate Cortactin at S000. As there are no available phospho S000 antibodies, the authors might instead IP Cortactin from p00-/- MEFs and blot with p-Ser antibodies or, better, ID sites by mass spec. I know this sort of experiments isn\'t fun or easy, but the use of phospho-mimics alone is not adequate to support their conclusions.  Reviewer \#0:  This manuscript identifies p00^kip0^ as a regulator of invadopodia formation and cell invasion, increasing the surprising number of cellular processes known to be regulated by this protein. While cytoplasmic p00^kip0^ was previously established to limit RhoA activity and stress fiber formation to promote cell migration, Jeannot et al