-0 cells (0×00^0^ cells mixed with 00% matrigel) were inoculated s.c. into both flanks of mice. Tumor-bearing mice were injected s.c. with RM-000 (000 mg/kg body weight) or vehicle only (0.0 mL of aqueous 0.0% methylcellulose:EtOH (00:0)) twice daily, every other day. T