  Reviewer \#0: Yes  Reviewer \#0: Yes  \*\*\*\*\*\*\*\*\*\*  0\. Have the authors made all data underlying the findings in their manuscript fully available?  The [PLOS Data policy](http://www.plosone.org/static/policies.action#sharing) requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data---e.g. participant privacy or use of data from a third party---those must be specified.  Reviewer \#0: Yes  Reviewer \#0: Yes  Reviewer \#0: No  \*\*\*\*\*\*\*\*\*\*  0\. Is the manuscript presented in an intelligible fashion and written in standard English?  PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.  Reviewer \#0: Yes  Reviewer \#0: Yes  Reviewer \#0: Yes  \*\*\*\*\*\*\*\*\*\*  0\. Review Comments to the Author  Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 00,000 characters)  Reviewer \#0: This is an interesting longitudinal study where the qualitative substudy yielded more interesting findings than the main quantitative study. I cannot help but feel the study is underpowered, and I gives some comments on the quantitative analysis that may make it more convincing.  0\. Sample size is based on a \"post-intervention effect size\" of 00%. I don\'t know what this means. A 00% improvement in the baseline QOL score? It is not clear what this effect size is for an ordinal measure like a questionnaire score.  0\. Repeated measures mixed effect models are used, but I cannot find the specific models examined, the assumptions of those models (including the covariance structure and a justification), or any diagnostics (residuals, Q-Q plots, etc.) that we would require of any student in a regression class to see if these models are really appropriate. I also wonder if the sample size computation would have been more appropriate by looking at sample size for repeated measures ANOVA models instead of a simple effect change (noting that I still don\'t know what the effect is!). Naturally, a more complicated model will require a larger sample size. I would also be interested in seeing a single longitudinal plot by subject superimposed for intervention and control  0\. The conclusions should clearly state whether the assumptions made in the sample size computation were realized in the study, and if not, what the impact of power is on the final analysis.  Reviewer \#0: This is an interesting paper that evaluated the feasibility and acceptability of the Italian READY for MS program, and preliminary assessed its efficacy when compared to an active control intervention(group relaxation). Although the program was well accepted by MS patients it was not more efficacious than relaxation.  The paper is well written and methodologically sound in most respects.  The measures utilized are suitable to the population and study questions.  However, certain issues require the authors attention in order to provide generalizability of the findings  0\. Were premorbid characteristics of the individuals (MS and HC) considered as covariates or found to be matched at baseline assessment (for e.g., Cognitive reserve, intelligence level, core personality characteristics). Resilience capacity may be influenced by these factors and especially cognitive flexibility and executive function capacity.  