. Asterisks indicate significant differences (p \< 0.00) (\* indicates significance when compared with controls; \*\* indicates significance when compared with controls and heterozygous Jak0^VF/+^; \*\*\* indicates significance when compared with controls, heterozygous Jak0^VF/+^ and hemizygous Jak0^VF/−^). Note that deletion of Jak0 WT allele 