: Performed the experiments; Analyzed and interpreted the data; Contributed reagents, materials, analysis tools or data; Wrote the paper.  Funding statement {#sec0.0} -----------------  This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.  Competing interest statement {#sec0.0} ----------------------------  The authors declare no conflict of interest.  Additional information {#sec0.0} ----------------------  No additional information is available for this paper.  Appendix A. Supplementary data {#appsec0} ==============================  The following is the supplementary data related to this article:Supp