   Recommended as adjunct treatment to oral therapy, for patients with contraindication to NSAIDs/coxibs or for patients who have not responded to oral therapy  AAOS, American Academy of Orthopaedic Surgeons; ACR, American College of Rheumatology; EULAR, European League Against Rheumatism; ICSI, Institute for Clinical Systems Improvement; NSAID, nonsteroidal anti-inflammatory drug