.  Conflict of interest {#FPar0} ====================  The authors declare that they have no conflict of interest.  Ethical approval {#FPar0} ================  All procedures performed in studies involving human participants were in accordance with the ethical standards of the national research committee and with the 0000 Helsinki declaration and its later amendments or comparable ethical standards.  Informed consent was obtained from all individual participants included in the study.  This article does not contain any studies with animals performed by any of the authors.  