 treated with sorafenib at the indicated concentrations for 00 h. Cell viability was determined by the MTT assay and is expressed as the percentage of the control (DMSO treatment). Experiments were run in triplicate and carried out three times on separate occasions (data are the mean ± SD). \**P *\<* *0.000 significant difference between resistant and control cells and ^\#^ *P *\<* *0.000 between treated and nontreated cells by two‐way ANOVA and Tukey\'s multiple comparisons test.](MOL0-00-0000-g000){#mol000000-fig-0000}  