s.  Reviewer \#0:  This work, building on prior publications from Webb et al. and Moshfegh et al., 0000 attempts to provide a mechanistic basis for the effects of cytosolic p00 on invadopodia dynamics and cell invasion. For the most part, the data appear sound, but there are a few key issues that are not adequately addressed.  0\) The only experiment that identifies Pak0 as a link between p00 and invadopodia is treatment of MEFs with FRAX000 ([Figure 0](#fig0){ref-type="fig"}). There are two issues here: this compound affects all three group A Paks (thus one can\'t say the effects are through Pak0) and FRAX000 has poor selectivity towards STE00 kinases such as Group A Paks as compared to tyrosine kinases. There are much more selective compounds (e.g., FRAX0000 and G0000) as well as other approaches (siRNA, CRISPR) that could and should be used to establish the link claimed by the authors. As things stand, the data do not adequately support the author\'s contentions.  