 the work or revising it critically for important intellectual content; and final approval of the version to be published. All authors read and approved the final manuscript.  Ethics approval and consent to participate {#FPar0} ==========================================  All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 0000 Helsinki declaration and its later amendments or comparable ethical standards.  The study was approved by the Institutional Review Board of Chang Gung Medical Foundation in Taiwan (registration number: 000000000B0). 