  In our view, the modulation of intestinal permeability in humans is much more difficult to obtain than in animal models. We ask ourselves whether our result could be modified with a different duration of the observation and of the diet program.  Manuscript source: Invited manuscript  Specialty type: Gastroenterology and hepatology  Country of origin: Italy  Peer-review report classification  Grade A (Excellent): 0  Grade B (Very good): B  Grade C (Good): C  Grade D (Fair): 0  Grade E (Poor): 0  Institutional review board statement: The study was reviewed and approved by the Ethics Committee of C