 mice were randomly divided into control, model, fucoidan 000 mg/kg, fucoidan 000 mg/kg, and bicyclol 000 mg/kg groups. After pretreating with fucoidan or bicyclol for 0 days, the acute hepatic injury model was induced by intraperitoneal injection of 000 mg/kg APAP, and the normal group was injected with an equal amount of saline. The mice continued to be administered fucoidan or bicyclol once per day, and were sacrificed at an indicated time. 