 proportion of patients had an arthropathy AE (0.0%; Fig. [0](#Fig0){ref-type="fig"}a) and the incidence of arthropathy AEs per patient-year was also low (0.00; 00% CI 0.00--0.00; Fig. [0](#Fig0){ref-type="fig"}b).  The incidence of arthropathy AEs in this group of patients was similar to that in the placebo group in the first treatment phase