\**P*\<0.00). (**A**--**E**) I, CD00RA^+^Foxp0^low^ resting Treg (rTreg) cells; II, CD00RA^−^Foxp0^high^ activated Treg (aTreg) cells; III, CD00RA^−^Foxp0^low^CD0^+^ T cells. TSNs, tumour culture supernatants.](bjc0000000f0){#fig0}  ![**Combined targeting of aTreg cells and M0 macrophages 