 Align GVGD (Tavtigian et al. [0000](#mgg0000-bib-0000){ref-type="ref"}), SIFT (Kumar et al. [0000](#mgg0000-bib-0000){ref-type="ref"}), PolyPhen0 (Adzhubei et al. [0000](#mgg0000-bib-0000){ref-type="ref"}), 