 in mice. Male ICR mice were randomly divided into control, model, fucoidan 000 mg/kg, fucoidan 000 mg/kg, and bicyclol 000 mg/kg groups. After pretreating with fucoidan or bicyclol for 0 days, the acute hepatic injury model was induced by intraperitoneal injection of 000 mg/kg APAP, and the normal group was injected with an equal amount of saline. The mice continued to be administered fucoidan or bicyclol once 