. Frequency distribution of methadone poisoning cases in 0000 had a significant difference with years of 0000, 0000, 0000, 0000 (*p* \< 0.000). Frequency distribution of methadone poisoning cases in 0000 had a significant difference with years of 0000, 0000, 0000, 0000 (*p* \< 0.000). Frequency distribution of methadone poisoning cases in 