 Chang Gung Medical Research Project (CORPG0G0000, CORPG0G0000, CORPG0G0000, CORPG0G0000).  Funding {#FPar0} =======  This study was funded by Chang Gung Medical Research Project (CORPG0G0000, CORPG0G0000, CORPG0G0000, CORPG0G0000).  Availability of data and materials {#FPar0} ==================================  The datasets used and analysed during the current study are available from the corresponding author on reasonable request.  D