ehicle control group; Group II: 0-OHDA treated group; Group III: Levodopa + 0-OHDA treated group; Group IV: PEFRE (000 mg/kg) + 0-OHDA treated group; Group V: PEFRE (000 mg/kg) + 0-OHDA treated group; Group VI: PEFRE (000 mg/kg) + 0-OHDA treated group. ^*∗∗∗*^ *p* \< 0.000 as compared to 0-OHDA treated negative control group (Group II). ^\#^ *p* \< 0.000 