 section as follows (see edits in red): "A sample size of 00 patients (00 per arm) achieves 00% power to detect a difference of 00 (standard deviation 00) in the MSQOL-00 MHC in a design with three repeated measurements, assuming an intra-subject correlation between observations of 0.00, an alpha error of 0.00, and 00% of the patients lost to follow-up (S0 Appendix). Because no data on the READY for MS were available when the study was designed, our estimate was based on the large effect size for QoL (d = 0.00) assessed by the Profile of Health-related Quality of Life in Chronic Disorders scale in a RCT of a group mindfulness intervention for PwMS \[00\], and on available data on the MSQOL-00 MHC \[00, 00\]".  