) There really isn\'t any proof that Cortactin gets phosphorylated by Pak at S000, only that substitutions at this residue affect invadopodia dynamics ([Figure 0](#fig0){ref-type="fig"}). What would have made the case much stronger are phospho-S000 blots and/or IFs showing that phosphorylation of this site is modulated by Rac/Pak. As far as I can tell, the initial paper from Webb et al., 0000, on which the present manuscript relies, only provided