 every other day. Tumor size (A) and body weight of mice (B) were recorded. Data represent the mean ± SEM \*\*: RM-000-treated group is significantly different from control (P \< 0.00). \*: RM-000-treated group is significantly different from control (P \< 0.00).](pone.0000000.g000){#pone.0000000.g000}  W