 were significantly decreased in the HG group compared with the control group (P\<0.00) and significantly increased in the SUMO+HG group compared with the Vect+HG group (P\<0.00; [Fig. 0C-E](#f0-mmr-00-00-0000){ref-type="fig"}).  ### Effect of SUMO0 overexpression on the TGF-β/Smad pathway in H0c0 cells treated with HG