 on bone turnover. *Top panel* Impact on responding osteoblasts (*R*, *red*), active osteoblasts (*B*, *blue*), and active osteoclasts (*C*, *green*); *Bottom panel* Impact on the active osteoclasts/osteoblast (*C*/*B*) ratio. The *solid lines* represent the simulated change in bone cells using the full model, whereas the *dashed lines* represent the respective changes using the mathematically reduced modelFig. 0Effect of 