bearing mice were injected s.c. with RM-000 (000 mg/kg body weight) or vehicle only (0.0 mL of aqueous 0.0% methylcellulose:EtOH (00:0)) twice daily, every other day. Tumor size (A) and body weight of mice (B) were recorded. Data represent the mean ± SEM \*\*: RM-000-treated group is significantly different from control (P \< 0.00).](pone.0000000.g000){#pone.0000000.g000}  An