ic acid000.0000000.00000.0000M + H0.000.000.0000HMDBLysopc(00:0)000.0000000.0000−0.0000M + H0.000.000.0000STDPc(00:0/00:0)000.0000000.0000−0.0000M + H0.000.000.0000HMDB^\*^Variable importance in the projection (VIP) was obtained from PLS-DA with a threshold of 0.0. ^†^p values were calculated from tests of statistical difference. Difference was considered statistically significant when p \< 0.00. ^‡^Fold change (FC) was calculated from the arithmetic mean values of 