, the cardiac *dSir0* expression level, dSIR0 level, NAD^+^ level, *PGC-0α* expression level, diastolic diameter, fractional shortening, arrhythmia index, heart TG level and *dFAS* expression of *dSir0*-KD-ND flies and *dSir0*-KD-HFD flies were not significantly different from that of *dSir0*-