 (*n* = 0--0). The bar in graph represents the average ± SD of the total number of the indicated cell population. \*, *p*\<0.000; \*\*, *p*\<0.00; \*\*\*, *p*\<0.00 compared with the levels of the indicated group.](ppat.0000000.g000){#ppat-0000000-g000}  Discussion {#s0} ==========  Although 