 P0 ([Figure 0---figure supplement 0](#fig0s0){ref-type="fig"}), P00 ([Figure 0---figure supplement 0](#fig0s0){ref-type="fig"}), P0 ([Figure 0---figure supplement 0](#fig0s0){ref-type="fig"}), P00 ([Figure 0---figure supplement 0](#fig0s0){ref-type="fig"}) and P00 ([Figure 0---figure supplement 0](#fig0s0){ref-type="fig"}) 