in femur and tibia) was significantly reduced in hemizygous and homozygous Jak0V000F mice at 00 weeks after pI-pC induction. Asterisks indicate significant differences (p \< 0.00) (\* indicates significance when compared with controls; \*\* indicates significance when compared with controls and heterozygous Jak0^VF/+^; \*\*\* indicates significance when compared with controls, heterozygous Jak0^VF/+^ and hemizygous Jak0^VF/−^).