 All microarray data are based on six probe replicates for each miRNA prediction (MCE-MIR, Cand and MIR) and eight probe replicates for mmu-mirs. ES and GCNF samples represent RNA isolated from pooled material from two independent 00 cm dishes with ∼00 million cells each from each time point of the ES and GCNF−/− time series experiment. For each time point, two dishes were pooled to harvest 0.0--0.0 mg of RNA for the arrays. Each time point is represented by duplicate arrays with dye swap of the label. 