                       00             00.0 (00.0)                00    00.0 (00.0)      0.00 (−0.00 to 00.00), 0.00    0.00    0.00   Quality of life                              00             00.0 (00.0)                00    00.0 (00.0)      0.00 (−0.00 to 00.00), 0.00    0.00    0.00  \*Analyses with multiple imputation for missing baseline and follow-up data points adjusted for baseline measures of outcome and minimisation variables (practice deprivation and practice size).  †Effect size based on pooled SD of baseline measures.  