 *et al.*[@b00]: 00% male-higher, 00% shift, *P*~Binom_adj~=0.0e-00; Zeisel *et al.*[@b00]: 00% male-higher, 00% shift, *P*~Binom_adj~=0.0e-00, [Supplementary Fig. 0f](#S0){ref-type="supplementary-material"}) and 