000 cells, as assessed by the scratch wound-healing (**B**) and Boyden chamber (**C**) assays. Hypoxia was started at T0 following 00-h incubation under normoxic conditions; the experiments were performed according to the same protocol as in [Figure 0A and B](#fig0){ref-type="fig"}.](bjc0000000f0){#fig0}  ![**HIF-0 inhibition decreases IGF-0-dependent signalling and enhances the anti-migratory effect of NVP-AEW000.** (**A**) Effect of 