. *R*^0^ between the estimated mutation load and actual mutation load was shown to be 0.0000 (Supplementary Fig. [0](#MOESM0){ref-type="media"}). The actual and estimated mutation loads of patient subgroups with different clinical characteristics are presented in Supplementary Figs. [0](#MOESM0){ref-type="media"} and [00](#MOESM0){ref-type="media"}, 