, which contains cDNA coding total amino acid sequence of human Delta-0 of the present invention, is transformed into E. coli JM000, has been deposited in the National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology, MITI, of 0-0-0, Higasi, Tsukuba-shi, Ibaragi-ken, Japan, as E. coli: JM000-pUC