The Steering Committee and an international expert panel (four persons) jointly discussed the study findings in two dedicated meetings (00 and 00 January 0000) and outlined the multi-centre RCT evaluation of the Italian READY for MS program. It was a structured discussion, using a "PICO" (Population, Intervention, Comparator, Outcomes) format \[00\]. The eligibility criteria of the pilot RCT, as well as the READY program were deemed adequate by the panel (Population and Intervention). To limit possible involuntary contaminations, the multi-centre RCT control group will be run by a psychologist not involved in "READY for MS training program" and with no expertise in ACT or mindfulness interventions (Comparator). Following Chmitorz et al. \[00\] and based on the trend differences in the CD-RISC 00 \[00\] observed in the pilot RCT, change in resilience at three month follow-up will be the primary trial endpoint. In addition, a longer follow-up assessment scheduled six months post-intervention was decided to evaluate effect maintenance (Outcomes)."  Journal Requirements:  When submitting your revision, we need you to address these additional requirements:  0\. Please ensure that your manuscript meets PLOS ONE\'s style requirements, including those for file naming. The PLOS ONE style templates can be found at <http://www.plosone.org/attachments/PLOSOne_formatting_sample_main_body.pdf> and <http://www.plosone.org/attachments/PLOSOne_formatting_sample_title_authors_affiliations.pdf>  