. The detailed *N* numbers of respective pan-cancer analyses in this study are presented in Supplementary Table [0](#MOESM0){ref-type="media"}.  Reporting summary {#Sec00} -----------------  Further information on research design is available in the [Nature Research Reporting Summary](#MOESM0){ref-type="media"} linked to this article.  Supplementary information =========================   {#Sec00}  Supplementary Information Reporting Summary  **Publisher's note** Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.  Supplementary information =========================  **Supplementary information** is available for this paper at 00.0000/s00000-000-0000