 data were normalized to control levels set as 0 and expressed as mean ± SEM (three independent experiments, one-way ANOVA with Tukey's post hoc test or Fisher LSD post hoc test, \* significant difference in comparison to the control: \* p ≤ 0.00).](pone.0000000.g000){#pone.0000000.g000}  As shown in [Fig 0A](#pone.0000000.g000){ref-type="fig"}, 