 flies were fed a HFD. Results showed that the cardiac *dSir0* expression level, dSIR0 level, NAD^+^ level, *PGC-0α* expression level, diastolic diameter, fractional shortening, arrhythmia index, heart TG level and *dFAS* expression of *dSir0*-OE-ND flies were not significantly different from that of *dSir0*-