.  Author Contributions ====================  All authors listed, have made substantial, direct and intellectual contribution to the work, and approved it for publication.  Conflict of Interest Statement ==============================  The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer SM and handling Editor declared their shared affiliation, and the handling Editor states that the process nevertheless met the standards of a fair and objective review.  **Funding.** This research was supported by the 