late                                                                                                                                                                                                                         Recommended as an adjunct treatment to oral therapy, for patients with contraindication to NSAIDs/coxibs or for patients who have not responded to oral therapy     AAOS, American Academy of Orthopaedic Surgeons; ACR, American College of Rheumatology; CCC, Canadian Consensus Conference; EULAR, European League Against Rheumatism; ICSI, Institute for Clinical Systems Improvement; NSAID, nonsteroidal anti-inflammatory drug