            −0.00 (±0.00)                                          −0.0 (±0.0)                                              00.0                                                  **00 WEEKS OF TREATMENT**                                                                                                                                                                                                             Linagliptin, 0 mg once daily (*n* = 000)                        −0.00 (±0.00)                                          −0.0 (±0.0)                                              00.0                                               Owens et al. ([@B00])   Placebo (*n* = 000)                                             −0.00 (±0.0)                                           +0.0 (±0.0)                                              0.0                                                   (Add-on therapy to metformin