. The data represent the mean and SEM of at least two combined independent experiments; \*, \*\*, \*\*\*, and \*\*\*\* denote a statistical significance of *p* ≤ 0.00, *p* ≤ 0.00, *p* ≤ 0.000, and *p* ≤ 0.0000, respectively, as tested by one-way ANOVA 