e under reflux for 00 hours. The synthetic procedure is illustrated in scheme I, below:  According to the '000 patent, 0-(0-chloropyrimidin-0-ylamino)benzonitrile of formula III-a can be prepared by reacting the 0-[(0,0-dihydro-0-oxo-0-pyrimidinyl)amino]benzonitrile with phosphorus oxytrichloride in the presence of methylene chloride and 0-propanone. Process for the preparation of rilpivirine was disclosed in U.S. Pat. No. 0,000,000 ('000 patent). According to the '000 patent, rilpivirine can be prepared by reacting the 