.  \[Note: HTML markup is below. Please do not edit.\]  Reviewers\' comments:  Reviewer\'s Responses to Questions  **Comments to the Author**  0\. Is the manuscript technically sound, and do the data support the conclusions?  The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.  Reviewer \#0: Yes  Reviewer \#0: Yes  Reviewer \#0: Partly  \*\*\*\*\*\*\*\*\*\*  0\. Has the statistical analysis been performed appropriately and rigorously?  Reviewer \#0: N