. Early and established RA are defined as disease duration \<0 and ≥0 year, respectively. ACR, American College of Rheumatology response criteria; DAS00-0(ESR), Disease Activity Score in 00 joints, erythrocyte sedimentation rate; MTX, methotrexate; RA, rheumatoid arthritis; vdHmTSS, van der Heijde modification of the total Sharp score.](rmdopen0000000000f00){#RMDOPEN0000000000F0}  