umor size (A) and body weight of mice (B) were recorded. Data represent the mean ± SEM. \*\*: RM-000-treated group is significantly different from control (P \< 0.00) \*: RM-000-treated group is significantly different from control (P \< 0.00).](pone.0000000.g000){#pone.0000000.g000}  Conclusion {#sec000} ==========  