 and statistical significance was determined using the Mann-Whitney test. Statistical significance was considered to be *p* \< 0.00. The sample size was calculated for an alpha of 0.00 and a power of 0.0.  Electronic supplementary material =================================   {#Sec00}  Supplementary information  **Electronic supplementary material**  **Supplementary information** accompanies this paper at doi:00.0000/s00000-000-00000-