 laboratory equipment \[[@pone.0000000.ref000]\] \[[@pone.0000000.ref000]\] \[[@pone.0000000.ref000]\] \[[@pone.0000000.ref000]\] \[[@pone.0000000.ref000]\] \[[@pone.0000000.ref000]\] \[[@pone.0000000.ref000]\] \[[@pone.0000000.ref000]\].  The 