 the calculation of total ESRseq score changes (ΔtESRseq) (Ke et al. [0000](#mgg0000-bib-0000){ref-type="ref"}; Di Giacomo et al. [0000](#mgg0000-bib-0000){ref-type="ref"}; Soukarieh et al. [0000](#mgg0000-bib-0000){ref-type="ref"}) 