0000000) and the National Natural Science Foundation of China (No. 00000000 and No. 00000000).  Data Availability =================  The data used to support the findings of this study are available from the corresponding authors upon request.  Conflicts of Interest =====================  The authors declare that they have no conflicts of interest.  Supplementary Materials {#supplementary-material-0} =======================  ######   Table S0: the sequences of the primers 