.  \[Editors\' note: the author responses to the re-review follow.\]  The manuscript has been improved but there are some remaining issues that need to be addressed before acceptance, as outlined below:  0\) While the colocalization of p00 and Tks0 in regions of degraded gelatin is now included in the manuscript, increasing confidence that these structures are bona fide invadopodia, it is not clear how specific the colocalization is compared to regions of the cell that are not associated with regions of gelatin degradation. I suggest the authors include line scans of regions of the cell not associated with gelatin degradation to demonstrate the specificity and import of the colocalization they now measure near regions of degraded gelatin.  