Name
stringlengths 14
548
| Synonym
stringlengths 14
790
⌀ | CAS RN
stringlengths 7
12
| Y
class label 2
classes | Detailed Page
stringlengths 57
580
| Evidence
stringlengths 40
2.31k
⌀ | OECD TG 404
stringclasses 1
value | Data Source
stringclasses 34
values | Frequency
int64 1
6
| SMILES
stringlengths 2
255
| SMILES URL
stringlengths 45
101
| SMILES Source
stringclasses 4
values | Canonical SMILES
stringlengths 2
248
| Split
stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EU_REACH:
heptylamine
NZ_CCID:
1-Heptanamine | null | 111-68-2 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21376/7/4/2/?documentUUID=da3261b7-0bd2-491d-a298-98121729689b
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3FDCD552-1EEB-4D8C-B7AE-6CC5FBF7A118 | EU_REACH:
Experimental study (OECD TG 404, GLP)
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | Provided | EU_REACH, NZ_CCID | 2 | CCCCCCCN | https://pubchem.ncbi.nlm.nih.gov/compound/8127 | PubChem | CCCCCCCN | Train |
JP_CHRIP:
2-(2-Methoxyethoxy)ethanol (synonym: Diethylene glycol monomethyl ether) | JP_CHRIP:
DEGME | 111-77-3 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2009.html | JP_CHRIP:
【分類根拠】
（１）、（２）より、区分に該当しない。
【根拠データ】
（１）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404 相当、閉塞、4時間適用、72時間観察）において、皮膚刺激性はみられなかった（紅斑・痂皮スコア：0/0/0/0/0/0、浮腫スコア：0/0/0/0/0/0）との報告がある（EU RAR (2000)、AICIS IMAP (2013)、REACH登録情報 (Accessed July 2021)、Government of Canada, Hazadous Substance Assessement (2020)）。
（２）ウサギ、モルモットを用いたDraize試験において、軽度の皮膚刺激性を示したとの報告がある（Government of Canada, Hazadous Substance Assessement (2020)）。 | Provided | JP_CHRIP | 1 | COCCOCCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.114D | J-GLOBAL | COCCOCCO | Train |
EU_REACH:
methyl undec-10-enoate | null | 111-81-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10072/7/4/2/?documentUUID=37d10816-0ce5-4a40-bd98-6a2464773183 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | COC(=O)CCCCCCCCC=C | https://pubchem.ncbi.nlm.nih.gov/compound/8138 | PubChem | C=CCCCCCCCCC(=O)OC | Train |
EU_REACH:
octan-1-amine
JP_CHRIP:
1-Octanamine
NZ_CCID:
Octylamine | NZ_CCID:
n-octylamine | 111-86-4 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16566/7/4/2/?documentUUID=987529f3-c3c1-4ff0-bb68-5322adbe51d1
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0007e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/49BD61B3-14EF-4370-8306-3D0EC143C390 | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
It was classified in Category 1 because it is reported that in an acute toxicity test by dermal administration to rabbits, necrosis was observed at the sites of application of this substance in the 200 mg/kg dose group during a 7-day observation period (RTECS (1997): the original article, United States Environmental Protection Agency, Office of Pesticides and Toxic Substances: 8EHQ-1085-0569), and it is also described that 1-octanamine is a severe skin irritant (PATTY (5th, 2001)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | Provided | EU_REACH, JP_CHRIP, NZ_CCID | 3 | CCCCCCCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.115B | J-GLOBAL | CCCCCCCCN | Train |
JP_CHRIP:
di-n-butylamine;
KR_NCIS:
Di-n-butylamine | JP_CHRIP:
di-n-butylamine
N-Butyl-1-butanamine
n-Dibutylamine
KR_NCIS:
Dibutylamine; N-Butyl-1-butanamine; N-Butylbutan-1-amine | 111-92-2 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0173e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | JP_CHRIP:
The classification was based on the description that the substance is found to be corrosive in Draize tests using rabbits (IUCLID (2000)). | null | JP_CHRIP, KR_NCIS | 2 | CCCCNCCCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.886J | J-GLOBAL | CCCCNCCCC | Train |
EU_REACH:
1,5-dimethyl pentanedioate | null | 1119-40-0 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5377/7/4/2/?documentUUID=e021234e-30db-497e-80e1-0dcf4c27823b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | COC(=O)CCCC(=O)OC | https://pubchem.ncbi.nlm.nih.gov/compound/14242 | PubChem | COC(=O)CCCC(=O)OC | Train |
NZ_CCID:
5-Chlorovaleric acid | null | 1119-46-6 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/42FACE71-DC2A-4576-AC67-F1EB3D13E280 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C(CCCl)CC(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/14244 | PubChem | O=C(O)CCCCCl | Train |
JP_CHRIP:
Thiacloprid | null | 111988-49-9 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2010.html | JP_CHRIP:
【分類根拠】
（１）～（３）より、区分に該当しない。
【根拠データ】
（１）ウサギを用いた皮膚刺激性試験において、皮膚刺激性はみられなかったとの報告がある（食安委 農薬評価書 (2019)）。
（２）ウサギ（n=3）を用いた皮膚刺激性試験（OECD TG 404）において、非常に軽度の紅斑が全例でみられたが、適用後72時間以内にすべて回復した（紅斑・痂皮スコア：1/1/0、浮腫スコア：0/0/0）との報告がある（ECHA RAC Opinion (2015)、CLH Report (2013)）。
（３）本物質はウサギに対して皮膚刺激物ではない（JMPR Report (2006)）。 | Provided | JP_CHRIP | 1 | Clc1ccc(CN2CCSC2=NC#N)cn1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.459.101J | J-GLOBAL | N#CN=C1SCCN1Cc1ccc(Cl)nc1 | Train |
NZ_CCID:
Dioctylamine | null | 1120-48-5 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/107CAA4D-F41F-4FB7-B069-E122EE5D080C | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CCCCCCCCNCCCCCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/3094 | PubChem | CCCCCCCCNCCCCCCCC | Train |
NZ_CCID:
Trichlorooctadecylsilane | NZ_CCID:
octadecyltrichlorosilane | 112-04-9 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB495C1C-ED21-40AF-BE7C-03ADFFD919A2 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/8157 | PubChem | CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl | Train |
EU_REACH:
(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide | null | 112101-81-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30158/7/4/2/?documentUUID=6427986c-cc44-4f80-96e2-adb0c20a46d7 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[C@H](CC1=CC(=C(C=C1)OC)S(=O)(=O)N)N | https://pubchem.ncbi.nlm.nih.gov/compound/10060387 | PubChem | COc1ccc(C[C@@H](C)N)cc1S(N)(=O)=O | Train |
NZ_CCID:
Decanoyl chloride | null | 112-13-0 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D2D0EAE-9D70-48EC-A7CF-137C20E661EF | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCCCCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/66982 | PubChem | CCCCCCCCCC(=O)Cl | Train |
NZ_CCID:
Lauroyl chloride | null | 112-16-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/219A2202-4420-421E-B98B-AB2B24BD2676 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCCCCCCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/8166 | PubChem | CCCCCCCCCCCC(=O)Cl | Train |
AU_HCIS:
1-Dodecanamine, N,N-dimethyl-
EU_REACH:
dodecyldimethylamine
JP_CHRIP:
N,N-Dimethyldodecan-1-ylamine
NZ_CCID:
Dimethyldodecylamine | JP_CHRIP:
dodecyldimethylamine
lauryldimethylamine
N,N-dimethyldodecylamine
NZ_CCID:
1-Dodecanamine, N,N-dimethyl-, Genamin LA 302 D, N,N-dimethyl-1-dodecanamine, N,N-dimethyldodecylamine, N,N-dimethyllaurylamine, armeen dm-12d, dodecyldimethylamine, lauryldimethylamine, monolauryl dimethylamine, n-dodecyldimethylamine, n-lauryldimethylamine | 112-18-5 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5000
EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14856/7/4/2/?documentUUID=dbc54309-bb73-4af9-810d-214ad44bea6c
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2005e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7FB884CC-31F2-4F06-9F08-0082B34C0E72 | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
[Rationale for the Classification]
Based on (1)-(3), it was classified in Category 1 according to the GHS Classification Guidance for the Japanese Government. Besides, although Category 1A is suggested from the information in (2), sub-categorization was not conducted since the information in (3) was also obtained.
[Evidence Data]
(1) It is reported that this substance is severely irritating to human skins (Environmental Risk Assessment for Chemical Substances vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)).
(2) There is a report that in a skin irritation test (OECD TG 404) with rabbits, both of the two products with different purities (the content of this substance: 95%, 70%) were corrosive after application for 4 hours or 3 minutes (SIDS (2004)).
(3) There are reports that in the skin irritation test (OECD TG 404) with rabbits, in all of two tests showing corrosivity and one test showing irritation, in which a 3-minute or 4-hour application was followed by a 1-hour observation, the erythema scores were lower than 4, and the criteria of Category 1A were not met (NICNAS IMAP (Accessed Oct. 2018)).
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT: Corrosive
REFERENCE SOURCE: Hoechst AG Frankfurt 80 Hoechst AG Frankfurt/Main [IUCLID 2000]
REMARK: EC Classification: Corrosive (causes burns)
Eye Irritation
SPECIES: Rabbit
RESULT: Moderately irritating
REFERENCE SOURCE: Hoechst AG Frankfurt 80 Hoechst AG Frankfurt/Main [IUCLID 2000]
REMARK: EC Classification: Irritating. | Provided | AU_HCIS, EU_REACH, JP_CHRIP, NZ_CCID | 4 | CCCCCCCCCCCCN(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J27.950A | J-GLOBAL | CCCCCCCCCCCCN(C)C | Train |
NZ_CCID:
Nonylamine | NZ_CCID:
n-nonylamine | 112-20-9 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5347AC53-41F6-4BD4-A6CE-2D570D252F4E | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCCCCCN | https://pubchem.ncbi.nlm.nih.gov/compound/16215 | PubChem | CCCCCCCCCN | Train |
AU_HCIS:
3,6-diazaoctanethylenediamin
JP_CHRIP:
3,6-diazaoctanethylenediamin; triethylenetetramine
NZ_CCID:
Triethylenetetramine | AU_HCIS:
triethylenetetramine
1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-
trientine
JP_CHRIP:
3,6-Diazaoctane-1,8-diamine
trientine
Triethylenetetramine
NZ_CCID:
1,4,7,10-Tetraazadecane, 1,8-Diamino-3,6-diazaoctane, 3,6-Diazaoctane-1,8-diamine, Araldite hardener HY 951, TETA, Tecza, Trien, Trientine | 112-24-3 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1203
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0042e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/914A6290-E1D7-4845-A4B9-FE061289559A | JP_CHRIP:
In rabbit skin tests, the substance caused not only erythema and edema, but also necrosis in several tests (SIDS (1998)). Thus, the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT:
Skin Irritation Grade 6. 6 = more necrosis from undiluted, less than edema from 10%.
REFERENCE SOURCE: [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2046]**PEER REVIEWED** [HSDB]
R PHRASE: R 34 [N-CLASS]
Eye Irritation
R-PHRASE: R 34 [N-CLASS] | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | NCCNCCNCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.120I | J-GLOBAL | NCCNCCNCCN | Train |
EU_REACH:
2,6,6-trimethylcyclohex-2-ene-1,4-dione | null | 1125-21-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6062/7/4/2/?documentUUID=25e23680-51ca-4220-b652-161f64b27635 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CC(=O)CC(C1=O)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/62374 | PubChem | CC1=CC(=O)CC(C)(C)C1=O | Train |
AU_HCIS:
3,6,9-triazaundecamethylenediamine
JP_CHRIP:
3,6,9-triazaundecamethylenediamine; tetraethylenepentamine
NZ_CCID:
Tetraethylenepentamine | AU_HCIS:
tetraethylenepentamine
1,2-Ethanediamine, N-(2-aminoethyl)-N'-[2-[(2-aminoethyl)amino]ethyl]-
JP_CHRIP:
1,11-Diamino-3,6,9-triazaundecane
3,6,9-Triazaundecane-1,11-diamine
TEPA
Tetraethylenepentamine
Tetrene | 112-57-2 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4545
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0044e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8F36AABA-11B0-4CDB-A52A-5BA52444ED0D | JP_CHRIP:
In several rabbit tests (Draize tests, etc.), exposure to the undiluted substance for 4 hours resulted in necrosis in half or more animals and the substance was concluded to be corrosive (SIDS (accessed in June 2008)). In addition, its EU Risk Phrase is "R34: corrosive" and its pH is >= 11.5. From these, the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [IUCLID 2000]
Eye Irritation
SPECIES: Rabbit
RESULT: Severe burns.
REFERENCE SOURCE: [Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968. 166]**PEER REVIEWED**[HSDB] | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | NCCNCCNCCNCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.129B | J-GLOBAL | NCCNCCNCCNCCN | Train |
NZ_CCID:
Tetradecanoyl chloride | null | 112-64-1 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FCDB945-04F4-47A2-9B24-32ABD85A6C15 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CCCCCCCCCCCCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/66986 | PubChem | CCCCCCCCCCCCCC(=O)Cl | Train |
NZ_CCID:
Palmitoyl chloride | null | 112-67-4 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB410A6C-0C28-4EF3-9D2C-8C11B6F17EED | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCCCCCCCCCCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/8206 | PubChem | CCCCCCCCCCCCCCCC(=O)Cl | Train |
EU_REACH:
1-[2-(2-butoxyethoxy)ethoxy]butane | null | 112-73-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5839/7/4/2/?documentUUID=a75bca5d-9bd3-4b29-b27a-e3e218dce05d | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCOCCOCCOCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/8210 | PubChem | CCCCOCCOCCOCCCC | Train |
NZ_CCID:
Oleoyl chloride | null | 112-77-6 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/11029E3A-A995-4626-9CAA-E84C7EEE9196 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCCCC/C=C\CCCCCCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/5364783 | PubChem | CCCCCCCC/C=C\CCCCCCCC(=O)Cl | Train |
AU_HCIS:
(Z)-octadec-9-enylamine
JP_CHRIP:
(Z)-9-Octadecen-1-amine; oleylamine
NZ_CCID:
Oleyl amine | AU_HCIS:
9-Octadecen-1-amine, (Z)-
JP_CHRIP:
(Z)-9-Octadecene-1-amine
(Z)-Octadec-9-en-1-ylamine | 112-90-3 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4780
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0083e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4D4A053D-3B5F-44F8-A629-523C7F2A07FE | JP_CHRIP:
It was classified in Category 1 because it is reported that necrosis was noted, and average Draize scores were 4.0 for both erythema and edema in a test by a 4-hour semi-occlusive application of 0.5 mL of the test substance to the rabbit skin (OECD TG 404), which was terminated for humane reasons (EU-RAR (2008)), and in another test with rabbits and almost the same test conditions (OECD TG 404), average Draize scores after 24, 48, and 72 hours for erythema and edema were 4.0, 3.7, and 3.7, and corrosive effects (eschar, scabbing, scarring) were observed at the application sites of all animals (EU-RAR (2008)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | Provided | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | CCCCCCCC/C=C\CCCCCCCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J59.382F | J-GLOBAL | CCCCCCCC/C=C\CCCCCCCCN | Train |
JP_CHRIP:
Guanidine | JP_CHRIP:
Guanidine monohydrochloride | 113-00-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0084e.html | JP_CHRIP:
It was classified in Category 1 because it is described that the pH of a 20% aqueous solution of this substance was 13.5 (Ullmanns (E) (6th, 2003)). | null | JP_CHRIP | 1 | NC(=N)N | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.462G | J-GLOBAL | N=C(N)N | Train |
EU_REACH:
3-morpholin-4-ylpropane-1-sulfonic acid | null | 1132-61-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21270/7/4/2/?documentUUID=5edc7b1e-e258-4b3e-8b0d-bc755d6eecc9 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1COCCN1CCCS(=O)(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/70807 | PubChem | O=S(=O)(O)CCCN1CCOCC1 | Train |
EU_REACH:
(2R)-5-cyclohexyl-2-methylpentan-1-ol; (2S)-5-cyclohexyl-2-methylpentan-1-ol | null | 1141487-54-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12526/7/4/2/?documentUUID=50687e9b-c1de-4dda-80ab-b6f75ef31d4c | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(CCCC1CCCCC1)CO | https://pubchem.ncbi.nlm.nih.gov/compound/44192644 | PubChem | CC(CO)CCCC1CCCCC1 | Train |
EU_REACH:
4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile | null | 114772-54-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2706/7/4/2/?documentUUID=073f47ac-933f-43d6-b011-aad39b702593 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC=C(C(=C1)C#N)C2=CC=C(C=C2)CBr | https://pubchem.ncbi.nlm.nih.gov/compound/1501912 | PubChem | N#Cc1ccccc1-c1ccc(CBr)cc1 | Train |
NZ_CCID:
Tribromoacetaldehyde | NZ_CCID:
Bromal | 115-17-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FC7AC182-A3F5-48B4-A4DA-47EBD00497E9 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | C(=O)C(Br)(Br)Br | https://pubchem.ncbi.nlm.nih.gov/compound/8256 | PubChem | O=CC(Br)(Br)Br | Train |
JP_CHRIP:
Trichloroethylsilane
NZ_CCID:
Trichloroethylsilane | null | 115-21-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0091e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E1AF554-0C60-4EA6-8917-5928949022D5 | JP_CHRIP:
Based on results that attacked region blanches and blisters after application to the skin of rabbits and that the substance is strong irritant (HSDB (2003)), the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | JP_CHRIP, NZ_CCID | 2 | CC[Si](Cl)(Cl)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.827J | J-GLOBAL | CC[Si](Cl)(Cl)Cl | Train |
EU_REACH:
N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide | null | 115258-10-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1845/7/4/2/?documentUUID=859bfad8-8741-4310-bd3c-3f32866035fa | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[Si](C)(C)O[Si](CCCNC(=O)C=C)(O[Si](C)(C)C)O[Si](C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/16050379 | PubChem | C=CC(=O)NCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C | Train |
EU_REACH:
1-benzyl-N-phenylpiperidin-4-amine | null | 1155-56-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23031/7/4/2/?documentUUID=45d50916-b094-4316-8c2b-d926cce09407 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CN(CCC1NC2=CC=CC=C2)CC3=CC=CC=C3 | https://pubchem.ncbi.nlm.nih.gov/compound/70865 | PubChem | c1ccc(CN2CCC(Nc3ccccc3)CC2)cc1 | Train |
EU_REACH:
triphenyl phosphate
JP_CHRIP:
Triphenyl Phosphate | JP_CHRIP:
Phosphoric acid, triphenyl ester
TPP
Triphenylphosphate | 115-86-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15972/7/4/2/?documentUUID=abff226e-be6f-4b87-ab1f-c427d9b5e967
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1000e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
From description that irritation was not admitted in the test applied to the skin of the rat for 4 hours on DFGOT (2 vol. 1991) and ACGIH (7th, 2001), it was carried out the outside of Category. | Provided | EU_REACH, JP_CHRIP | 2 | O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.469D | J-GLOBAL | O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1 | Train |
JP_CHRIP:
Tris(2-chloroethyl) phosphate | JP_CHRIP:
Ethanol, 2-chloro-, phosphate (3:1)
TCEP
Tri(beta-chloroethyl) phosphate
Tris(2-chloroethyl) orthophosphate
tris(2-chloroethyl)phosphate | 115-96-8 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0012e.html | JP_CHRIP:
In two reports on skin irritation tests (OECD TG 404) using rabbits, it is reported that slight erythema was observed, but this resolved within 24 hours (EU-RAR (2009)). In addition, it is described that in a skin irritation test using rabbits, as the result of applying 0.5 mL of this substance for 4 hours under a semi-occlusive dressing, slight erythema was observed in all animals on Day 1 after application, but there were no signs of irritation (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), EHC 209 (1998)).
From the above, this substance was classified as "Not classified" (Category 3 in UN GHS classification). Based on the added information, the category was changed according to the GHS Classification Guidance for the Japanese Government. | Provided | JP_CHRIP | 1 | ClCCOP(=O)(OCCCl)OCCCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.095I | J-GLOBAL | O=P(OCCCl)(OCCCl)OCCCl | Train |
EU_REACH:
methyl 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | null | 1160293-25-3 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26465/7/4/2/?documentUUID=83b2bbd2-662e-42ac-9734-8761663d1e87 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | COC(=O)C1=CC2=C(CC(=O)N2C(=O)CCl)C=C1 | https://pubchem.ncbi.nlm.nih.gov/compound/42634136 | PubChem | COC(=O)c1ccc2c(c1)N(C(=O)CCl)C(=O)C2 | Train |
EU_REACH:
hexachloropropan-2-one | null | 116-16-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17343/7/4/2/?documentUUID=0dc9628b-4cad-4b06-af67-d81b5e5cd83d | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(=O)(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/8303 | PubChem | O=C(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl | Train |
NZ_CCID:
2-Methylbutyric acid | null | 116-53-0 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7F2DD93B-C132-4BFB-8960-83C145F6A991 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCC(C)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/8314 | PubChem | CCC(C)C(=O)O | Train |
EU_REACH:
1,4-bis(mesitylamino)anthraquinone | null | 116-75-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5736/7/4/2/?documentUUID=db4b62d3-46d7-4889-97ef-71a724c00b96 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CC(=C(C(=C1)C)NC2=C3C(=C(C=C2)NC4=C(C=C(C=C4C)C)C)C(=O)C5=CC=CC=C5C3=O)C | https://pubchem.ncbi.nlm.nih.gov/compound/61042 | PubChem | Cc1cc(C)c(Nc2ccc(Nc3c(C)cc(C)cc3C)c3c2C(=O)c2ccccc2C3=O)c(C)c1 | Train |
EU_REACH:
methyl (3E)-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | null | 1168150-46-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27187/7/4/2/?documentUUID=cc2dbdf9-a473-473a-841b-57550a10a424 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CO/C(=C/1\C2=C(C=C(C=C2)C(=O)OC)NC1=O)/C3=CC=CC=C3 | https://pubchem.ncbi.nlm.nih.gov/compound/42634134 | PubChem | COC(=O)c1ccc2c(c1)NC(=O)/C2=C(/OC)c1ccccc1 | Train |
EU_REACH:
4-chloro-1,3-dihydro-2-benzofuran-1,3-dione | null | 117-21-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11567/7/4/2/?documentUUID=e6c0a0d5-dd5c-4032-b7e6-1a4b0a021f1e | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC2=C(C(=C1)Cl)C(=O)OC2=O | https://pubchem.ncbi.nlm.nih.gov/compound/67014 | PubChem | O=C1OC(=O)c2c(Cl)cccc21 | Train |
EU_REACH:
2-(naphthalene-2-sulfonamido)benzoic acid | null | 117309-52-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23982/7/4/2/?documentUUID=01d7ab5c-6f8a-47e9-a11a-2d8469c71732 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)NC3=CC=CC=C3C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/4798771 | PubChem | O=C(O)c1ccccc1NS(=O)(=O)c1ccc2ccccc2c1 | Train |
EU_REACH:
methyl (2E)-3-methoxy-2-[2-({[6-(trifluoromethyl)pyridin-2-yl]oxy}methyl)phenyl]acrylate | null | 117428-22-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21001/7/4/2/?documentUUID=349e85bc-f90d-4892-8207-a003afb591e1 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CO/C=C(\C1=CC=CC=C1COC2=CC=CC(=N2)C(F)(F)F)/C(=O)OC | https://pubchem.ncbi.nlm.nih.gov/compound/11285653 | PubChem | CO/C=C(/C(=O)OC)c1ccccc1COc1cccc(C(F)(F)F)n1 | Train |
EU_REACH:
Methyl-2-(2-chloromethylphenyl)-3-methoxy-2-acrylate | null | 117428-95-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11725/7/4/2/?documentUUID=e967bddc-7d24-4f00-8e87-91e69767ed1d | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CO/C=C(/C1=CC=CC=C1CCl)\C(=O)OC | https://pubchem.ncbi.nlm.nih.gov/compound/10130990 | PubChem | CO/C=C(\C(=O)OC)c1ccccc1CCl | Train |
EU_REACH:
2-[2-(carboxymethyl)phenoxy]-3,4-dimethylbenzoic acid | null | 117570-93-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2727/7/4/2/?documentUUID=edda16c9-f94b-4696-a119-5846d400d09d | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=C(C(=C(C=C1)C(=O)O)OC2=CC=CC=C2CC(=O)O)C | https://pubchem.ncbi.nlm.nih.gov/compound/14885557 | PubChem | Cc1ccc(C(=O)O)c(Oc2ccccc2CC(=O)O)c1C | Train |
JP_CHRIP:
Bis(2-ethylhexyl) phthalate | JP_CHRIP:
Bis(2-ethylhexyl) phthalate
Bis-(2-ethylhexyl)phthalate
DEHP
Di(2-ethylhexy)phthalate
Di(2-ethylhexyl) phthalate
Di(2-ethylhexyl)phthalate
di-2-ethylhexyl phthalate
Diethylhexyl phthalate
dioctyl benzene-1,2-dicarboxylate
Dioctyl phthalate
Dioctylphthalate
DOP; DEHP | 117-81-7 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2081e.html | JP_CHRIP:
There are 2 reports of skin irritation tests (OECD TG 404) with rabbits. In one study, neither erythema nor edema was observed, and the irritation score was 0 (EU-RAR (2003)). In the other study, although slight erythema (3/3 animals) at 1 hour after application, significant erythema (1/3 animals) at 24 hours after application, and slight erythema (3/3 of the animals) at 48 hours after application were observed, they resolved 8 days after application, therefore, it was judged to be slightly irritating (EU-RAR (2003)). In addition, in another skin irritation test with rabbits (FDA recommended method, GLP-compliant), after 24-hour application of this substance, slight to moderate skin reaction was observed but this disappeared after 48 hours, therefore, it was judged to be slightly irritating (EU-RAR (2003)). Moreover, there is a report that in humans, the undiluted liquid of this substance was applied occlusively to the backs of 23 subjects for 7 days and reapplied on the 10th day, and no skin reaction was observed (EU-RAR (2003)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). The category was changed according to the revised GHS classification guidance for the Japanese government. | Provided | JP_CHRIP | 1 | CCCCC(CC)COC(=O)c1ccccc1C(=O)OCC(CC)CCCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.909B | J-GLOBAL | CCCCC(CC)COC(=O)c1ccccc1C(=O)OCC(CC)CCCC | Train |
EU_REACH:
N-(3,5-dichloro-4-ethyl-2-hydroxyphenyl)hexadecanamide | null | 117827-06-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6149/7/4/2/?documentUUID=b0b6bcec-57f4-4f69-ae45-859a4752f0f9 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCCCCCCCCCCCCC(=O)NC1=CC(=C(C(=C1O)Cl)CC)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/14344747 | PubChem | CCCCCCCCCCCCCCCC(=O)Nc1cc(Cl)c(CC)c(Cl)c1O | Train |
EU_REACH:
3-[(3R)-3-amino-2,3,4,9-tetrahydro-1H-carbazol-9-yl]propanoic acid | null | 1182722-58-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12204/7/4/2/?documentUUID=ce3e9b8c-c03f-4805-8ac7-cdc05d5bf9eb | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CC2=C(C[C@@H]1N)C3=CC=CC=C3N2CCC(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/46928273 | PubChem | N[C@@H]1CCc2c(c3ccccc3n2CCC(=O)O)C1 | Train |
EU_REACH:
trans-5-butyl-2-(3',3'',4'',5''-tetrafluoro-1,1':4',1''-terphenyl-4-yl)-1,3-dioxane | null | 1182844-21-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29749/7/4/2/?documentUUID=681ee1e5-13fa-4a70-a8de-02f217f299fa | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCC1COC(OC1)C2=CC=C(C=C2)C3=CC(=C(C=C3)C4=CC(=C(C(=C4)F)F)F)F | https://pubchem.ncbi.nlm.nih.gov/compound/132042669 | PubChem | CCCCC1COC(c2ccc(-c3ccc(-c4cc(F)c(F)c(F)c4)c(F)c3)cc2)OC1 | Train |
EU_REACH:
hexaphenoxy-1,3,5,2λ⁵,4λ⁵,6λ⁵-triazatriphosphinine | null | 1184-10-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30500/7/4/2/?documentUUID=2b6d5add-28a9-4284-a647-9d182b19f902 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC=C(C=C1)OP2(=NP(=NP(=N2)(OC3=CC=CC=C3)OC4=CC=CC=C4)(OC5=CC=CC=C5)OC6=CC=CC=C6)OC7=CC=CC=C7 | https://pubchem.ncbi.nlm.nih.gov/compound/136917 | PubChem | c1ccc(OP2(Oc3ccccc3)=NP(Oc3ccccc3)(Oc3ccccc3)=NP(Oc3ccccc3)(Oc3ccccc3)=N2)cc1 | Train |
EU_REACH:
5-chloro-1,3-dihydro-2-benzofuran-1,3-dione | null | 118-45-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12546/7/4/2/?documentUUID=d508a43e-401a-4f86-9f4a-9acb086633a2 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC2=C(C=C1Cl)C(=O)OC2=O | https://pubchem.ncbi.nlm.nih.gov/compound/67044 | PubChem | O=C1OC(=O)c2cc(Cl)ccc21 | Train |
EU_REACH:
4-(3,5-dichlorobenzamido)-3-hydroxybenzoic acid | null | 1184581-58-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27410/7/4/2/?documentUUID=6c2ec289-2390-485b-bdce-b97314f46345 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC(=C(C=C1C(=O)O)O)NC(=O)C2=CC(=CC(=C2)Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/60825179 | PubChem | O=C(O)c1ccc(NC(=O)c2cc(Cl)cc(Cl)c2)c(O)c1 | Train |
EU_REACH:
1,4-diethyl 2-(2-oxopropyl)butanedioate | null | 1187-74-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1510/7/4/2/?documentUUID=d1ca5732-c110-4546-8901-d12c33bd3213 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC(=O)CC(CC(=O)C)C(=O)OCC | https://pubchem.ncbi.nlm.nih.gov/compound/5463816 | PubChem | CCOC(=O)CC(CC(C)=O)C(=O)OCC | Train |
EU_REACH:
1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone | null | 1190865-44-1 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32348/7/4/2/?documentUUID=cbd17be7-29ac-45a8-ba17-20b98a1c2040 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=C(C=C(C(=C1Cl)F)Cl)C(=O)C(F)(F)F | https://pubchem.ncbi.nlm.nih.gov/compound/75530023 | PubChem | O=C(c1cc(Cl)c(F)c(Cl)c1)C(F)(F)F | Train |
EU_REACH:
3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid | null | 119-17-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13434/7/4/2/?documentUUID=7af4c05a-40b5-42fd-a96d-e79f14d129dd | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=NN(C(=O)C1)C2=CC(=CC=C2)S(=O)(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/67060 | PubChem | CC1=NN(c2cccc(S(=O)(=O)O)c2)C(=O)C1 | Train |
EU_REACH:
(3aS,3bR,9aS,9bR,11aS)-9a,11a-dimethyl-8-(morpholin-4-yl)-2-(pyrrolidin-1-yl)-hexadecahydro-1H-cyclopenta[a]phenanthrene-1,7-diol | null | 119302-20-4 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7282/7/4/2/?documentUUID=b5120f69-1dfa-4c1c-99c5-7c47137ba9ff | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@@H]([C@@H]2O)N4CCCC4)CC[C@@H]5[C@@]3(C[C@@H]([C@H](C5)O)N6CCOCC6)C | https://pubchem.ncbi.nlm.nih.gov/compound/16063873 | PubChem | C[C@]12C[C@H](N3CCOCC3)[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)[C@@H](N3CCCC3)C[C@@H]12 | Train |
EU_REACH:
2-benzyl-2-(dimethylamino)-1-[4-(morpholin-4-yl)phenyl]butan-1-one
JP_CHRIP:
2-Benzyl-2-(N,N-dimethylamino)-1-(4-morpholinophenyl)butan-1-one | null | 119313-12-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1145/7/4/2/?documentUUID=c308d4e8-3e9a-41c1-a00b-bb2f082bb774
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0002e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
[Rationale for the Classification]
It was classified as "Not classified" from (1), (2).
[Evidence Data]
(1) No skin reactions were observed in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on June 2020)).
(2) No skin reactions were seen in a skin irritation test with rabbits according to EU Method B.4 (Acute Toxicity: Dermal Irritation/Corrosion) (REACH registration dossier (Access on June 2020)). | Provided | EU_REACH, JP_CHRIP | 2 | CCC(Cc1ccccc1)(N(C)C)C(=O)c1ccc(cc1)N1CCOCC1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J261.950D | J-GLOBAL | CCC(Cc1ccccc1)(C(=O)c1ccc(N2CCOCC2)cc1)N(C)C | Train |
KR_NCIS:
4,6-Dichloropyrimidine | null | 1193-21-1 | 1Cat 1
| KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | KR_NCIS | 1 | C1=C(N=CN=C1Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/70943 | PubChem | Clc1cc(Cl)ncn1 | Train |
EU_REACH:
6-hydroxypyrimidin-4(3H)-one | null | 1193-24-4 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5164/7/4/2/?documentUUID=90eac021-7cb1-48d4-91f4-06f7ce519f18 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=C(N=CNC1=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/14512 | PubChem | O=c1cc(O)nc[nH]1 | Train |
EU_REACH:
2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one | null | 119344-86-4 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15616/7/4/2/?documentUUID=055fc99b-f8bb-4064-8461-21392930a973 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCC(CC1=CC=C(C=C1)C)(C(=O)C2=CC=C(C=C2)N3CCOCC3)N(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/22019755 | PubChem | CCC(Cc1ccc(C)cc1)(C(=O)c1ccc(N2CCOCC2)cc1)N(C)C | Train |
JP_CHRIP:
2,6-Dichlorobenzonitrile; Dichlobenil | JP_CHRIP:
2,6-Dichlorobenzonitrile
2,6-Dichlorophenylcyanide
DBN | 1194-65-6 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2041e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1)-(4), it was classified as "Not classified."
[Evidence Data]
(1) In a skin irritation test in which this substance (85.3% formulation) was administered to rabbits according to EPA TG81-5 (corresponding to OECD TG 404), it is reported not to be a dermal irritant (EPA Pesticide (1998), REACH registration dossier (Access on August 2019)).
(2) In a skin irritation test with rabbits, no irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)).
(3) In a skin irritation test with rabbits (4-hour application), the scores 30-60 minutes after application and 24/48/72 hours after were all 0 and no irritation was observed (Agricultural Chemicals Times supplement Vol.10 (Japan Crop Protection Association, 1991)).
(4) This substance was not irritating to the skin of rabbits (JMPR (2014)). | Provided | JP_CHRIP | 1 | Clc1cccc(Cl)c1C#N | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.365K | J-GLOBAL | N#Cc1c(Cl)cccc1Cl | Train |
EU_REACH:
2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol | null | 119-47-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/4/2/?documentUUID=acbbd449-9b9e-4a13-8efd-cb8530505947 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CC(=C(C(=C1)C(C)(C)C)O)CC2=C(C(=CC(=C2)C)C(C)(C)C)O | https://pubchem.ncbi.nlm.nih.gov/compound/8398 | PubChem | Cc1cc(Cc2cc(C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1 | Train |
EU_REACH:
diphenylmethanone
JP_CHRIP:
Benzophenone | JP_CHRIP:
Benzoylbenzene
Diphenyl ketone
Phenyl ketone | 119-61-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13823/7/4/2/?documentUUID=5e9a31d6-89a6-44b3-a490-d1f15501ac72
JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2010.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
【分類根拠】
（１）より、区分に該当しない。なお、新たな知見に基づき、分類結果を変更した。
【根拠データ】
（１）ウサギ（n=4）を用いた皮膚刺激性試験（OECD TG 404、GLP、2～100％（原液）、半閉塞、4時間適用、72時間観察）において、濃度100％まで皮膚刺激性の徴候は認められなかったとの報告がある（AICIS IMAP (2015)、REACH登録情報 (Accessed Dec. 2021)）。 | Provided | EU_REACH, JP_CHRIP | 2 | O=C(c1ccccc1)c1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.481C | J-GLOBAL | O=C(c1ccccc1)c1ccccc1 | Train |
EU_REACH:
1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone | null | 119851-28-4 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2113/7/4/2/?documentUUID=3e861be4-4e9e-4d56-89b6-e094e09dbd15 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=O)C1=C(C=C(C=C1)OC2=CC=C(C=C2)Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/677479 | PubChem | CC(=O)c1ccc(Oc2ccc(Cl)cc2)cc1Cl | Train |
KR_NCIS:
3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-diamine | KR_NCIS:
3,3'-Dimethoxybenzidine | 119-90-4 | 1Cat 1
| KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | KR_NCIS | 1 | COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N)OC)N | https://pubchem.ncbi.nlm.nih.gov/compound/8411 | PubChem | COc1cc(-c2ccc(N)c(OC)c2)ccc1N | Train |
EU_REACH:
4-(4-hydroxybenzoyloxy)-3-methylphenyl 4-hydroxybenzoate | null | 119959-84-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33665/7/4/2/?documentUUID=026b0aab-161d-435f-bbdb-6ab724102de8 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)O)OC(=O)C3=CC=C(C=C3)O | https://pubchem.ncbi.nlm.nih.gov/compound/10992120 | PubChem | Cc1cc(OC(=O)c2ccc(O)cc2)ccc1OC(=O)c1ccc(O)cc1 | Train |
EU_REACH:
480-680-7 | null | 120128-90-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13705/7/4/2/?documentUUID=1503ef99-75ae-454c-882e-2968022b13ea | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[N+](C)(CCCNC=O)CC(=O)[O-] | https://pubchem.ncbi.nlm.nih.gov/compound/5287757 | PubChem | C[N+](C)(CCCNC=O)CC(=O)[O-] | Train |
EU_REACH:
3-amino-4-methoxy-N-phenylbenzamide | null | 120-35-4 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11279/7/4/2/?documentUUID=1b8e5b99-8ae3-4a31-848c-da5b45a24817 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)N | https://pubchem.ncbi.nlm.nih.gov/compound/8426 | PubChem | COc1ccc(C(=O)Nc2ccccc2)cc1N | Train |
EU_REACH:
benzyl benzoate
JP_CHRIP:
benzyl benzoate | JP_CHRIP:
Benzoic acid, phenylmethyl ester
Benzyl benzenecarboxylate | 120-51-4 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13634/7/4/2/?documentUUID=f0f6e844-bd09-4c6b-a62d-097bc9b901b2
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0178e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
In Draize tests using rabbits, the average scores of the treated animals that received 4-hour applications of this substance for 3 days were 0 to 1.58 (ECETOC TR 66 (1995)). Based on these results, the substance was classified into the "Not classified" category. | Provided | EU_REACH, JP_CHRIP | 2 | O=C(OCc1ccccc1)c1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.327I | J-GLOBAL | O=C(OCc1ccccc1)c1ccccc1 | Train |
EU_REACH:
2-[2-(benzoyloxy)ethoxy]ethyl benzoate | null | 120-55-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/4/2/?documentUUID=b5c20315-fe6b-4262-ad93-9eb0db0cab85 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC=C(C=C1)C(=O)OCCOCCOC(=O)C2=CC=CC=C2 | https://pubchem.ncbi.nlm.nih.gov/compound/8437 | PubChem | O=C(OCCOCCOC(=O)c1ccccc1)c1ccccc1 | Train |
JP_CHRIP:
Dimethyl terephthalate | JP_CHRIP:
Dimethyl 1,4-benzenedicarboxylate
Dimethyl p-phthalate | 120-61-6 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2007.html | JP_CHRIP:
【分類根拠】
（１）～（３）より、区分に該当しない（国連分類基準の区分3）。
【根拠データ】
（１）モルモットを用いた皮膚刺激性試験において、軽度の刺激性を示したとの報告がある（NITE初期リスク評価書 (2008)）。
（２）ウサギ（n = 6）を用いた皮膚刺激性試験（OECD TG 404相当、半閉塞、4時間適用、72時間観察）において、皮膚一次刺激指数（PII）は0であった（紅斑・痂皮スコア：0/0/0/0/0/0、浮腫スコア：0/0/0/0/0/0）との報告がある（REACH登録情報 (Accessed Nov. 2021)）。
（３）ウサギを用いた皮膚刺激性試験（4時間適用、24時間観察）において、観察期間中に刺激はみられなかったとの報告がある（産衛学会許容濃度の暫定値の提案理由書 (2020)）。 | Provided | JP_CHRIP | 1 | COC(=O)c1ccc(cc1)C(=O)OC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.003F | J-GLOBAL | COC(=O)c1ccc(C(=O)OC)cc1 | Train |
EU_REACH:
3-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione | null | 1207-75-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22543/7/4/2/?documentUUID=5578c8ff-4520-43d8-837c-8a517c19c62c | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC=C2C(=C1)C(=O)N(C(=O)N2)CCO | https://pubchem.ncbi.nlm.nih.gov/compound/71016 | PubChem | O=c1[nH]c2ccccc2c(=O)n1CCO | Train |
EU_REACH:
N-methyl-1-(trans-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide | null | 1208319-26-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32698/7/4/2/?documentUUID=5ab3230a-d471-4185-914a-7821f0618c40 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3 | https://pubchem.ncbi.nlm.nih.gov/compound/44631938 | PubChem | CNS(=O)(=O)CC1CCC(N(C)c2ncnc3[nH]ccc23)CC1 | Train |
JP_CHRIP:
2,4-Dichlorophenol
NZ_CCID:
2,4-Dichlorophenol | JP_CHRIP:
2,4-DCP
Phenol, 2,4-dichloro- | 120-83-2 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0013e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31BDD982-C6FC-4700-A595-FEF5B93A0560 | JP_CHRIP:
It is reported that strong irreversible necrosis was observed after applying this substance (80% aqueous solution) to rabbit skin for 15 minutes (SIDS (2008)). In addition, many cases of deaths of workers exposed to this substance were reported (SIDS (2008), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment) Vol. 8 (2010)). It is described that contact with only 1% of the body surface may lead to death. From the above, this substance was classified in Category 1. Besides, it is classified as "Skin Corr. 1B H 314" in the EU CLP classification (ECHA C&L Inventory (Access on June 2015)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | Oc1ccc(Cl)cc1Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.005B | J-GLOBAL | Oc1ccc(Cl)cc1Cl | Train |
KR_NCIS:
1-Methylpyrrolidine | null | 120-94-5 | 1Cat 1
| KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | KR_NCIS | 1 | CN1CCCC1 | https://pubchem.ncbi.nlm.nih.gov/compound/8454 | PubChem | CN1CCCC1 | Train |
EU_REACH:
2-Chloro-1-(1-chlorocyclopropyl)ethanone | null | 120983-72-4 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9302/7/4/2/?documentUUID=54bc83d5-8e31-4a70-a1c0-0c26cb0fa45e | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CC1(C(=O)CCl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/11062580 | PubChem | O=C(CCl)C1(Cl)CC1 | Train |
JP_CHRIP:
2-Methyl-5-nitrobenzenesulfonic acid | JP_CHRIP:
2-methyl-5-nitrobenzenesulfonic acid | 121-03-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0086e.html | JP_CHRIP:
It is reported that it was moderately irritating in a test in which 20 mg of this substance was applied to the rabbit skin for 24 hours (IUCLID (2000), RTECS (1997)), but it was classified in Category 1 from the knowledge that the pH of an aqueous solution (100 g/L) of this substance was less than 1 (IUCLID (2000)). | null | JP_CHRIP | 1 | Cc1ccc(cc1S(=O)(=O)O)[N+](=O)[O-] | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.070F | J-GLOBAL | Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)O | Train |
EU_REACH:
1-ethoxy-2,3-difluorobenzene | null | 121219-07-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22555/7/4/2/?documentUUID=1ccbfe49-5d7a-476d-82ca-f6177223fe75 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC1=C(C(=CC=C1)F)F | https://pubchem.ncbi.nlm.nih.gov/compound/2782928 | PubChem | CCOc1cccc(F)c1F | Train |
AU_HCIS:
triethylamine
JP_CHRIP:
Triethylamine
KR_NCIS:
Triethylamine
NZ_CCID:
Ethanamine, N,N-diethyl-
US_HSDB:
TRIETHYLAMINE | AU_HCIS:
Ethanamine, N,N-diethyl-
JP_CHRIP:
N,N-Diethylethanamine
KR_NCIS:
N,N-Diethylethanamine
NZ_CCID:
(Diethylamino)ethane, TEA, Triethylamine, n,n-Diethylethanamine | 121-44-8 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4580
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0118e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/997D38F8-A52C-4958-84D4-2B474B59B18D
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/896 | JP_CHRIP:
In a skin irritation test using rabbits under occlusive application for 3 minutes, 1 hour or 4 hours, it was found to be corrosive (DFGOT Vol.13 (1999)). Therefore, this substance was classified in Category 1.
NZ_CCID:
Skin Irritation
R-PHRASE: R 35 Causes severe burns. [IUCLID 2000]
Eye Irritation
SPECIES: Rabbit
RESULT: Strongly alkaline and when drop is applied to the rabbits eye, causes severe injury, graded 9 on a scale of 1 to 10 after 24 hr/ Most severe injuries ahve been rated 10. tests of aq soln on rabbit eyes @ pH 10 and pH 11 indicate injuriousness of triethylamine/ is rated principally to degree of alkalinity. Chronic exposure of rabbits to vapours @ concn as low as 50 ppm in air causes multiple erosions of cornea and conjunctiva in 6 weeks.
REFERENCE SOURCE: [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 944]**PEER REVIEWED** [HSDB] | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 5 | CCN(CC)CC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.485F | J-GLOBAL | CCN(CC)CC | Train |
EU_REACH:
4-methanesulfonyl-2-(trifluoromethyl)benzaldehyde | null | 1215310-75-0 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27232/7/4/2/?documentUUID=1d540db8-6860-476c-99e4-1d4927980fc6 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CS(=O)(=O)C1=CC(=C(C=C1)C=O)C(F)(F)F | https://pubchem.ncbi.nlm.nih.gov/compound/51342018 | PubChem | CS(=O)(=O)c1ccc(C=O)c(C(F)(F)F)c1 | Train |
EU_REACH:
(1r,4r)-N1,N1,N4,N4-tetrakis(2-hydroxyethyl)cyclohexane-1,4-dicarboxamide | null | 1215841-86-3 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5440/7/4/2/?documentUUID=37975966-991f-4aa2-9b8c-8b61d1d30bd8 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CC(CCC1C(=O)N(CCO)CCO)C(=O)N(CCO)CCO | https://pubchem.ncbi.nlm.nih.gov/compound/58434361 | PubChem | O=C(C1CCC(C(=O)N(CCO)CCO)CC1)N(CCO)CCO | Train |
NZ_CCID:
4-Acetamidobenzenesulphonyl chloride | NZ_CCID:
N-acetylsulfanilyl chloride | 121-60-8 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1ECCEC52-E782-484C-AE66-CBA9069E87F9 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC(=O)NC1=CC=C(C=C1)S(=O)(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/8481 | PubChem | CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1 | Train |
EU_REACH:
9-[(3,3'-di-tert-butyl-2'-{8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaen-9-yloxy}-5,5'-dimethoxy-[1,1'-biphenyl]-2-yl)oxy]-8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaene | null | 121627-17-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12308/7/4/2/?documentUUID=7c029f5e-a96b-45e4-9a4a-3758f6009c89 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)(C)C1=CC(=CC(=C1OP2OC3=CC=CC=C3C4=CC=CC=C4O2)C5=C(C(=CC(=C5)OC)C(C)(C)C)OP6OC7=CC=CC=C7C8=CC=CC=C8O6)OC | https://pubchem.ncbi.nlm.nih.gov/compound/10865829 | PubChem | COc1cc(-c2cc(OC)cc(C(C)(C)C)c2Op2oc3ccccc3c3ccccc3o2)c(Op2oc3ccccc3c3ccccc3o2)c(C(C)(C)C)c1 | Train |
AU_HCIS:
Benzenesulfonic acid, 4-dodecyl- | null | 121-65-3 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4887 | null | null | AU_HCIS | 1 | CCCCCCCCCCCCC1=CC=C(C=C1)S(=O)(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/8485 | PubChem | CCCCCCCCCCCCc1ccc(S(=O)(=O)O)cc1 | Train |
EU_REACH:
2,2-dichloro-1-[5-(furan-2-yl)-2,2-dimethyl-1,3-oxazolidin-3-yl]ethan-1-one | null | 121776-33-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7356/7/4/2/?documentUUID=cedd60ea-7013-42a2-ae58-6debacb290c5 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1(N(CC(O1)C2=CC=CO2)C(=O)C(Cl)Cl)C | https://pubchem.ncbi.nlm.nih.gov/compound/86187 | PubChem | CC1(C)OC(c2ccco2)CN1C(=O)C(Cl)Cl | Train |
JP_CHRIP:
Hexahydro-1,3,5-trinitro-1,3,5-triazine (with 15% water, by mass) | JP_CHRIP:
1,3,5-Triaza-1,3,5-trinitrocyclohexane
Cyclonite
Cyclotrimethylenetrinitramine
Hexahydro-1,3,5-trinitro-1,3,5-triazine
Hexogen
RDX
RDX (Royal Demolition Explosive) | 121-82-4 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2037e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified as "Not classified." Besides, the category was changed, since new data were obtained.
[Evidence Data]
(1) In a skin irritation test with rabbits equivalent or similar to OECD TG 404, the number of animals whose scores were 1 or above consecutively until 72 hours was only one out of six, and all of the scores for other animals were zero at 72 hours (REACH registration dossier (Access on August 2019)).
[Reference Data, etc.]
(2) There are a report that no irritation was observed in a human patch test (dose unknown) and a report that dermatitis was induced (ATSDR (2012)).
(3) Slight erythema was induced in guinea pigs exposed to this substance (1,000 mg/kg) (ATSDR (2012)).
(4) Dermatitis was induced in rabbits by exposure to this substance in acetone (27 mg/kg), in cyclohexane (37.5 mg/kg), or in DMSO (165 mg/kg) (ATSDR (2012)). | Provided | JP_CHRIP | 1 | [O-][N+](=O)N1CN(CN(C1)[N+](=O)[O-])[N+](=O)[O-] | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.346E | J-GLOBAL | O=[N+]([O-])N1CN([N+](=O)[O-])CN([N+](=O)[O-])C1 | Train |
EU_REACH:
2-chloro-1-methyl-4-nitrobenzene | null | 121-86-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1542/7/4/2/?documentUUID=efe61ba0-d389-4a51-9bb7-08d4fd5a0b37 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=C(C=C(C=C1)[N+](=O)[O-])Cl | https://pubchem.ncbi.nlm.nih.gov/compound/8491 | PubChem | Cc1ccc([N+](=O)[O-])cc1Cl | Train |
NZ_CCID:
4-Nitrobenzoyl chloride | null | 122-04-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1F70CA0D-4102-4E3F-A3EC-2619F1D31B9D | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC(=CC=C1C(=O)Cl)[N+](=O)[O-] | https://pubchem.ncbi.nlm.nih.gov/compound/8502 | PubChem | O=C(Cl)c1ccc([N+](=O)[O-])cc1 | Train |
EU_REACH:
O,O-dimethyl O-3-methyl-4-nitrophenyl phosphorothioate
JP_CHRIP:
O,O-Dimethyl-O-(3-methyl-4-nitrophenyl) thiophosphate [Fenitrothion] | JP_CHRIP:
Fenitrothion
O,O'-dimethyl-O-(3-methyl-4-nitrophenyl) monothiophosphate
O,O'-Dimethyl-O-(3-methyl-4-nitrophenyl)phosphorothioate
O,O-Dimethyl O-3-methyl-4-nitrophenyl phosphorothioate
O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
O,O-Dimethyl O-4-nitro-m-tolyl thiophosphate
O,O-Dimethyl-O-(3-methyl-4-nitrophenyl) thiophosphate
Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester | 122-14-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27782/7/4/2/?documentUUID=efd959b1-f517-4b3e-b2ee-82f05036fee8
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2076e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
Based on a report that skin irritation was not observed in a skin irritation test with rabbits (EHC 133 (1992), Risk Assessment Report (Pesticides and Veterinary Medicinal Products) (Food Safety Commission of Japan, 2014)), it was classified as "Not classified." The category was revised based on the information obtained in this research. | Provided | EU_REACH, JP_CHRIP | 2 | COP(=S)(OC)Oc1ccc(c(C)c1)[N+](=O)[O-] | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.492I | J-GLOBAL | COP(=S)(OC)Oc1ccc([N+](=O)[O-])c(C)c1 | Train |
EU_REACH:
3-hydroxy-4-{[2-methoxy-5-(phenylcarbamoyl)phenyl]diazenyl}-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-naphthamide | null | 12225-06-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13914/7/4/2/?documentUUID=b3d41585-a0af-42b5-bcd4-723bc1697f3c | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | COc1ccc(cc1N\N=C2/C(=O)C(=Cc3ccccc23)C(=O)Nc4ccc5NC(=O)Nc5c4)C(=O)Nc6ccccc6 | https://cactus.nci.nih.gov/chemical/structure/12225-06-8/smiles | CACTUS | COc1ccc(C(=O)Nc2ccccc2)cc1N/N=C1\C(=O)C(C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)=Cc2ccccc21 | Train |
EU_REACH:
N-(4-chloro-2,5-dimethoxyphenyl)-2-{[2,5-dimethoxy-4-(phenylsulfamoyl)phenyl]diazenyl}-3-oxobutanamide | null | 12225-18-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11078/7/4/2/?documentUUID=286f124c-4bfa-47eb-b7d5-81bc70834824 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=O)C(C(=O)NC1=CC(=C(C=C1OC)Cl)OC)N=NC2=CC(=C(C=C2OC)S(=O)(=O)NC3=CC=CC=C3)OC | https://pubchem.ncbi.nlm.nih.gov/compound/61559 | PubChem | COc1cc(NC(=O)C(N=Nc2cc(OC)c(S(=O)(=O)Nc3ccccc3)cc2OC)C(C)=O)c(OC)cc1Cl | Train |
EU_REACH:
N-(4-acetamidophenyl)-4-[(5-carbamoyl-2-chlorophenyl)diazenyl]-3-hydroxy-2-naphthamide | null | 12236-64-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10624/7/4/2/?documentUUID=6892ac2e-658d-4d03-a82d-fde7d2bfdedd | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=O)NC1=CC=C(C=C1)NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=C(C=CC(=C4)C(=O)N)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/82995 | PubChem | CC(=O)Nc1ccc(NC(=O)c2cc3ccccc3c(N=Nc3cc(C(N)=O)ccc3Cl)c2O)cc1 | Train |
JP_CHRIP:
Triethoxymethane | JP_CHRIP:
Ethyl orthoformate | 122-51-0 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0105e.html | JP_CHRIP:
Based on a result of "not irritating" in a rabbit test (OECD TG404 (GLP)) (IUCLID (2000)), the substance was classified as "Not classified". | Provided | JP_CHRIP | 1 | CCOC(OCC)OCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.533F | J-GLOBAL | CCOC(OCC)OCC | Train |
JP_CHRIP:
Triethyl phosphite | JP_CHRIP:
Phosphorous acid, triethyl ester | 122-52-1 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0005e.html | JP_CHRIP:
Based on results of "slightly irritating" (PDII: 1.4) in a rabbit test (OECD TG404) (SIDS (2003)) and "mildly irritating" (PDII: 1.7) in another rabbit Draize test (SIDS (2003)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). | Provided | JP_CHRIP | 1 | CCOP(OCC)OCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.007I | J-GLOBAL | CCOP(OCC)OCC | Train |
NZ_CCID:
Cyclohexanone peroxide, 30-60%, 30-60% dibutyl phthalate, 10-30% ethyl acetate | NZ_CCID:
Cyclohexanone peroxide | 12262-58-7 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BFC446A9-880E-4187-8708-5DF6B980A43A | NZ_CCID:
Skin Irritation
R-PHRASE: R 34 Causes Burns. [N-Class]
Eye Irritation
SPECIES: Rabbit
RESULT: Severe
REFERENCE SOURCE: [Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. (8,25,1958)] [RTECS] | null | NZ_CCID | 1 | C1CCC(CC1)(O)OOC2(CCCCC2)OO | https://pubchem.ncbi.nlm.nih.gov/compound/6521 | PubChem | OOC1(OOC2(O)CCCCC2)CCCCC1 | Train |
EU_REACH:
4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl methacrylate | null | 1228350-17-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18171/7/4/2/?documentUUID=ba69bd97-7c66-452a-888c-5fbb792423ca | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=C)C(=O)OCCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F | https://pubchem.ncbi.nlm.nih.gov/compound/19098704 | PubChem | C=C(C)C(=O)OCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | Train |
EU_REACH:
3-octyl-1-[4-({4-[(octylcarbamoyl)amino]phenyl}methyl)phenyl]urea | null | 122886-55-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16583/7/4/2/?documentUUID=a47fcfce-f39a-4f64-a226-911cb22f8936 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCCCCCNC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)NCCCCCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/14299396 | PubChem | CCCCCCCCNC(=O)Nc1ccc(Cc2ccc(NC(=O)NCCCCCCCC)cc2)cc1 | Train |
EU_REACH:
4-(4-iodo-1H-pyrazol-1-yl)piperidine | null | 1229457-94-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5524/7/4/2/?documentUUID=3d776ce8-229b-4ae8-ba55-b87b733b64b1 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CNCCC1N2C=C(C=N2)I | https://pubchem.ncbi.nlm.nih.gov/compound/53256681 | PubChem | Ic1cnn(C2CCNCC2)c1 | Train |
EU_REACH:
3-morpholin-4-ylpropan-1-amine
NZ_CCID:
4-Morpholinepropanamine | NZ_CCID:
(3-Aminopropyl)morpholine, 1-Amino-3-morpholinopropane, 3-Morpholinopropanamine, 3-Morpholinopropylamine, 4-(3-Aminopropyl)morpholine, Morpholine, 4-(3-aminopropyl)- (8CI), Morpholine, 4-aminopropyl-, Morpholine, N-aminopropyl-, N-(3-Aminopropyl)morpholine, N-Aminopropylmorpholine, gamma-Morpholinopropylamine | 123-00-2 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24742/7/4/2/?documentUUID=6d8b456b-10a7-4a35-9942-a0fe7f5ef67a
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4EAC4513-4CEC-4A78-9CB8-F5B140AB94F3 | EU_REACH:
Experimental study (OECD TG 404, GLP)
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT: Extremely irritating/ Corrosive
REFERENCE SOURCE: (http://www.huntsman.com/performance_chemicals/Media/APM.pdf)
Eye Irritation
SPECIES: Rabbit
RESULT: Extremely irritating/ Corrosive
REFERENCE SOURCE: (http://www.huntsman.com/performance_chemicals/Media/APM.pdf) | Provided | EU_REACH, NZ_CCID | 2 | C1COCCN1CCCN | https://pubchem.ncbi.nlm.nih.gov/compound/61055 | PubChem | NCCCN1CCOCC1 | Train |
EU_REACH:
14,14',15,15'-tetradehydro-7,7'-spirobi[dibenzo[b,g][1,9,4,6]dioxadiazacyclododecine] | null | 1231148-36-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6054/7/4/2/?documentUUID=378da222-d36f-4739-a917-65aa83fe80d1 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1C2(COC3=CC=CC=C3N=C=NC4=CC=CC=C4O1)COC5=CC=CC=C5N=C=NC6=CC=CC=C6OC2 | https://pubchem.ncbi.nlm.nih.gov/compound/58434418 | PubChem | C1=Nc2ccccc2OCC2(COc3ccccc3N=1)COc1ccccc1N=C=Nc1ccccc1OC2 | Train |
EU_REACH:
4-[(3-carboxypropanoyl)peroxy]-4-oxobutanoic acid | null | 123-23-9 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24749/7/4/2/?documentUUID=84c9b78d-2fa5-49a9-95c5-086fa74344d0 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(CC(=O)OOC(=O)CCC(=O)O)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/31248 | PubChem | O=C(O)CCC(=O)OOC(=O)CCC(=O)O | Train |
EU_REACH:
1,4-diethyl butanedioate | null | 123-25-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27981/7/4/2/?documentUUID=c266f723-64cd-466a-b644-0e18b70e9dfe | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC(=O)CCC(=O)OCC | https://pubchem.ncbi.nlm.nih.gov/compound/31249 | PubChem | CCOC(=O)CCC(=O)OCC | Train |