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<|startoftext|><L>Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c<mask_1:4>c3)cn12<mask_1:4> | 8 | 39 | 4 | 3ccc(F)c | 4 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccoc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | 3cco |
<|startoftext|><L>Cn1c(=<mask_1:8>c2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12<mask_1:8> | 5 | 6 | 8 | O)n(C | 8 | Cn1c(=O)/c(=C/c2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | O)/c(=C/ |
<|startoftext|><L>Cn1c(=O)n<mask_1:7>2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12<mask_1:7> | 3 | 9 | 7 | (Cc | 7 | Cn1c(=O)n(CC#CCc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | (CC#CCc |
<|startoftext|><L>Cn1c(=O)n(Cc<mask_1:5>cccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12<mask_1:5> | 2 | 12 | 5 | 2c | 5 | Cn1c(=O)n(Cc2c(F)cccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | 2c(F) |
<|startoftext|><L>Cn1c(=O)n(Cc2ccccc2Cl)c<mask_1:8>)c2c1nc1oc(-c3ccc(F)cc3)cn12<mask_1:8> | 3 | 23 | 8 | (=O | 8 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | (=O)c(=O |
<|startoftext|><L>Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)c<mask_1:3>)cn12<mask_1:3> | 2 | 47 | 3 | c3 | 3 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3F)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | c3F |
<|startoftext|><L>Cn1<mask_1:3>Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12<mask_1:3> | 7 | 3 | 3 | c(=O)n( | 3 | Cn1nc(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | nc( |
<|startoftext|><L>Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3<mask_1:2>F)cc3)cn12<mask_1:2> | 4 | 40 | 2 | ccc( | 2 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3c(F)cc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | c( |
<|startoftext|><L>Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc<mask_1:4>c3ccc(F)cc3)cn12<mask_1:4> | 2 | 36 | 4 | (- | 4 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(CCOc3ccc(F)cc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | (CCO |
<|startoftext|><L>Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc<mask_1:5>cc3)cn12<mask_1:5> | 3 | 43 | 5 | (F) | 5 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(C#N)cc3)cn12 | Cn1c(=O)n(Cc2ccccc2Cl)c(=O)c2c1nc1oc(-c3ccc(F)cc3)cn12 | (C#N) |
<|startoftext|><L>Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1ncc<mask_1:6>C(F)(F)F<mask_1:6> | 4 | 33 | 6 | n1C) | 6 | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1ncc[nH]1)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | [nH]1) |
<|startoftext|><L>Cc1c(Cl<mask_1:1>cc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F<mask_1:1> | 3 | 7 | 1 | )cc | 1 | Cc1c(Cl)cc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | ) |
<|startoftext|><L>Cc1c(Cl)c<mask_1:3>ccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F<mask_1:3> | 0 | 9 | 3 | 3 | Cc1c(Cl)c(F)ccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | (F) |
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<|startoftext|><L>Cc1c(Cl)cccc1NC(=O)C[C<mask_1:1>(c1nccn1C)C(F)(F)F<mask_1:1> | 5 | 22 | 1 | @](O) | 1 | Cc1c(Cl)cccc1NC(=O)C[C](c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | ] |
<|startoftext|><L>Cc1c(C<mask_1:1>l)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F<mask_1:1> | 0 | 6 | 1 | 1 | Cc1c(CCl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | C |
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<|startoftext|><L>Cc1c(Cl)cccc1NC<mask_1:3>O)C[C@](O)(c1nccn1C)C(F)(F)F<mask_1:3> | 2 | 15 | 3 | (= | 3 | Cc1c(Cl)cccc1NCC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | C(= |
<|startoftext|><L>Cc1c(<mask_1:1>)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F<mask_1:1> | 2 | 5 | 1 | Cl | 1 | Cc1c(F)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | F |
<|startoftext|><L>Cc1c(Cl)cccc1NC<mask_1:6>[C@](O)(c1nccn1C)C(F)(F)F<mask_1:6> | 5 | 15 | 6 | (=O)C | 6 | Cc1c(Cl)cccc1NC(=O)NC[C@](O)(c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | (=O)NC |
<|startoftext|><L>Cc1c(Cl)cccc1NC(=O)C[C<mask_1:1>(O)(c1nccn1C)C(F)(F)F<mask_1:1> | 2 | 22 | 1 | @] | 1 | Cc1c(Cl)cccc1NC(=O)C[C](O)(c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | ] |
<|startoftext|><L>Cc1c(Cl)cccc1NC(=O)C[C@](<mask_1:3>ccn1C)C(F)(F)F<mask_1:3> | 6 | 25 | 3 | O)(c1n | 3 | Cc1c(Cl)cccc1NC(=O)C[C@](c1nccn1C)C(F)(F)F | Cc1c(Cl)cccc1NC(=O)C[C@](O)(c1nccn1C)C(F)(F)F | c1n |
<|startoftext|><L>O=C1NC(=Nc2ccc<mask_1:3>)S/C1=C\C=C\c1ccccc1<mask_1:3> | 4 | 14 | 3 | cc2F | 3 | O=C1NC(=Nc2ccccc2)S/C1=C\C=C\c1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | cc2 |
<|startoftext|><L>O=C1NC(=Nc2ccccc2<mask_1:4>)S/C1=C\C=C\c1ccccc1<mask_1:4> | 1 | 17 | 4 | F | 4 | O=C1NC(=Nc2ccccc2)C(O)S/C1=C\C=C\c1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | )C(O |
<|startoftext|><L>O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1c<mask_1:3>1<mask_1:3> | 4 | 33 | 3 | cccc | 3 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccco1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | cco |
<|startoftext|><L>O=C1NC(=Nc2ccccc2F)S/C1<mask_1:1>C=C\c1ccccc1<mask_1:1> | 3 | 23 | 1 | =C\ | 1 | O=C1NC(=Nc2ccccc2F)S/C1=C=C\c1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | = |
<|startoftext|><L>O=C1NC(=N<mask_1:5>c2ccccc2F)S/C1=C\C=C\c1ccccc1<mask_1:5> | 0 | 9 | 5 | 5 | O=C1NC(=N/N=C\c2ccccc2F)S/C1=C\C=C\c1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | /N=C\ |
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<|startoftext|><L>O=C1NC(=Nc2ccccc2F)S/C1=<mask_1:2>\C=C\c1ccccc1<mask_1:2> | 1 | 24 | 2 | C | 2 | O=C1NC(=Nc2ccccc2F)S/C1=C\\C=C\c1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | C\ |
<|startoftext|><L>O=C1NC(=Nc2ccccc2<mask_1:2>C1=C\C=C\c1ccccc1<mask_1:2> | 4 | 17 | 2 | F)S/ | 2 | O=C1NC(=Nc2ccccc2)SC1=C\C=C\c1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | )S |
<|startoftext|><L>O=C1NC(=Nc2ccccc2F)S/C1=C\C<mask_1:1>c1ccccc1<mask_1:1> | 3 | 27 | 1 | =C\ | 1 | O=C1NC(=Nc2ccccc2F)S/C1=C\CSc1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | S |
<|startoftext|><L>O=C1NC(=Nc2ccccc2F)S/C1=C\C=C<mask_1:4>ccccc1<mask_1:4> | 3 | 29 | 4 | \c1 | 4 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\Nc1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | \Nc1 |
<|startoftext|><L>O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\<mask_1:1>c1ccccc1<mask_1:1> | 0 | 30 | 1 | 1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\Nc1ccccc1 | O=C1NC(=Nc2ccccc2F)S/C1=C\C=C\c1ccccc1 | N |
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<|startoftext|><L>O=C(c1ccc(Cl)cc1)<mask_1:3>1ccc(Br)cc1<mask_1:3> | 1 | 17 | 3 | c | 3 | O=C(c1ccc(Cl)cc1)OCc1ccc(Br)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | OCc |
<|startoftext|><L>O=C(c1ccc(Cl)cc1)c1ccc(Br<mask_1:2>1<mask_1:2> | 3 | 25 | 2 | )cc | 2 | O=C(c1ccc(Cl)cc1)c1ccc(Br)o1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | )o |
<|startoftext|><L>O=C(c<mask_1:3>(Cl)cc1)c1ccc(Br)cc1<mask_1:3> | 4 | 5 | 3 | 1ccc | 3 | O=C(c1sc(Cl)cc1)c1ccc(Br)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | 1sc |
<|startoftext|><L>O=C(c1ccc(Cl)cc1)c1ccc(<mask_1:4>)cc1<mask_1:4> | 2 | 23 | 4 | Br | 4 | O=C(c1ccc(Cl)cc1)c1ccc(OCCO)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | OCCO |
<|startoftext|><L>O=C(c1ccc(Cl)cc1)c1cc<mask_1:3>Br)cc1<mask_1:3> | 2 | 21 | 3 | c( | 3 | O=C(c1ccc(Cl)cc1)c1ccc(CBr)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | c(C |
<|startoftext|><L>O<mask_1:2>C(c1ccc(Cl)cc1)c1ccc(Br)cc1<mask_1:2> | 1 | 1 | 2 | = | 2 | O=CC(c1ccc(Cl)cc1)c1ccc(Br)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | =C |
<|startoftext|><L>O=C(c1ccc(Cl)cc1)c1c<mask_1:4>c(Br)cc1<mask_1:4> | 1 | 20 | 4 | c | 4 | O=C(c1ccc(Cl)cc1)c1cc(F)c(Br)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | c(F) |
<|startoftext|><L>O=C(c1ccc(Cl)cc1)c1ccc(<mask_1:4>)cc1<mask_1:4> | 2 | 23 | 4 | Br | 4 | O=C(c1ccc(Cl)cc1)c1ccc(SCCO)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | SCCO |
<|startoftext|><L>O=C(c1ccc(Cl)cc1)c1c<mask_1:4>Br)cc1<mask_1:4> | 3 | 20 | 4 | cc( | 4 | O=C(c1ccc(Cl)cc1)c1ccc(CBr)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | cc(C |
<|startoftext|><L>O=C(c1ccc(Cl)c<mask_1:4>1)c1ccc(Br)cc1<mask_1:4> | 1 | 14 | 4 | c | 4 | O=C(c1ccc(Cl)c(F)c1)c1ccc(Br)cc1 | O=C(c1ccc(Cl)cc1)c1ccc(Br)cc1 | (F)c |
<|startoftext|><L>C[C@@H](<mask_1:3>)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1<mask_1:3> | 4 | 8 | 3 | /C(O | 3 | C[C@@H](C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C(O |
<|startoftext|><L>C[C@@H](/C(O)=N/[C@@H]1CCO<mask_1:4>(C)(C)C1)N1CCOCC1<mask_1:4> | 1 | 26 | 4 | C | 4 | C[C@@H](/C(O)=N/[C@@H]1CCO[C@](C)(C)C1)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | [C@] |
<|startoftext|><L>C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCO<mask_1:1>CC1<mask_1:1> | 0 | 41 | 1 | 1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C |
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<|startoftext|><L>C[C@@H](/<mask_1:3>/[C@@H]1CCOC(C)(C)C1)N1CCOCC1<mask_1:3> | 6 | 9 | 3 | C(O)=N | 3 | C[C@@H](/C=C/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C=C |
<|startoftext|><L>C[C@@H](/C(O)=N/[C@@H]1CCOC(C<mask_1:1>C)C1)N1CCOCC1<mask_1:1> | 2 | 29 | 1 | )( | 2 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | )( |
<|startoftext|><L>C[C@@H](/C(O)=<mask_1:6>C@@H]1CCOC(C)(C)C1)N1CCOCC1<mask_1:6> | 3 | 14 | 6 | N/[ | 6 | C[C@@H](/C(O)=N/CCS[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | N/CCS[ |
<|startoftext|><L>C[C@@H](/C(<mask_1:2>N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1<mask_1:2> | 3 | 11 | 2 | O)= | 3 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | O)= |
<|startoftext|><L>C[C@@H](/C(O)=N<mask_1:6>C@@H]1CCOC(C)(C)C1)N1CCOCC1<mask_1:6> | 2 | 15 | 6 | /[ | 6 | C[C@@H](/C(O)=N/CCCN[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | /CCCN[ |
<|startoftext|><L>C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1<mask_1:5>)N1CCOCC1<mask_1:5> | 0 | 35 | 5 | 5 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)C(=O)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | )C(=O |
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<|startoftext|><L>C[C@@H](/C(O)=N/[C@@H]1C<mask_1:2>OC(C)(C)C1)N1CCOCC1<mask_1:2> | 1 | 24 | 2 | C | 2 | C[C@@H](/C(O)=N/[C@@H]1CCCOC(C)(C)C1)N1CCOCC1 | C[C@@H](/C(O)=N/[C@@H]1CCOC(C)(C)C1)N1CCOCC1 | CC |
<|startoftext|><L>Cn1cnnc1Sc1cc<mask_1:5>c(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1<mask_1:5> | 0 | 13 | 5 | 5 | Cn1cnnc1Sc1cc(C#N)c(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | (C#N) |
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<|startoftext|><L>Cn1cnnc1Sc1ccc(<mask_1:5>CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1<mask_1:5> | 0 | 15 | 5 | 5 | Cn1cnnc1Sc1ccc(C(=O)CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | C(=O) |
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<|startoftext|><L>Cn1cnnc1Sc1ccc(CN2C<mask_1:1>CO[C@H](CO)[C@H]2c2ccccc2)o1<mask_1:1> | 0 | 19 | 1 | 1 | Cn1cnnc1Sc1ccc(CN2CCCO[C@H](CO)[C@H]2c2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | C |
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<|startoftext|><L>Cn1cnnc1Sc1ccc(CN2CCO[C@H]<mask_1:3>H]2c2ccccc2)o1<mask_1:3> | 7 | 26 | 3 | (CO)[C@ | 3 | Cn1cnnc1Sc1ccc(CN2CCO[C@H][C@H]2c2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | [C@ |
<|startoftext|><L>Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H<mask_1:7>cccc2)o1<mask_1:7> | 5 | 34 | 7 | ]2c2c | 7 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2CCc2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | ]2CCc2c |
<|startoftext|><L>Cn1cnnc1Sc1ccc(CN2CCO[C@H<mask_1:6>CO)[C@H]2c2ccccc2)o1<mask_1:6> | 2 | 25 | 6 | ]( | 6 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](COCCCO)[C@H]2c2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | ](COCC |
<|startoftext|><L>Cn1cnnc1Sc1c<mask_1:7>CCO[C@H](CO)[C@H]2c2ccccc2)o1<mask_1:7> | 6 | 12 | 7 | cc(CN2 | 7 | Cn1cnnc1Sc1ccc(CN2CCCO[C@H](CO)[C@H]2c2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | cc(CN2C |
<|startoftext|><L>Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2<mask_1:3>ccccc2)o1<mask_1:3> | 2 | 36 | 3 | c2 | 3 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2Cc2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | Cc2 |
<|startoftext|><L>Cn1cnnc1Sc1<mask_1:7>CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1<mask_1:7> | 4 | 11 | 7 | ccc( | 7 | Cn1cnnc1Sc1ccc(CNCCN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | ccc(CNC |
<|startoftext|><L>Cn1cnnc1Sc1ccc(C<mask_1:2>[C@H](CO)[C@H]2c2ccccc2)o1<mask_1:2> | 5 | 16 | 2 | N2CCO | 2 | Cn1cnnc1Sc1ccc(CN2[C@H](CO)[C@H]2c2ccccc2)o1 | Cn1cnnc1Sc1ccc(CN2CCO[C@H](CO)[C@H]2c2ccccc2)o1 | N2 |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c<mask_1:5>2)nn1-c1ccccc1<mask_1:5> | 6 | 36 | 5 | 2ccccc | 5 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2cccs2)nn1-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | 2cccs |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1c<mask_1:2>c1<mask_1:2> | 3 | 51 | 2 | ccc | 2 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccsc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | cs |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(<mask_1:4>2)nn1-c1ccccc1<mask_1:4> | 8 | 34 | 4 | -c2ccccc | 4 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(C2CC2)nn1-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | C2CC |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c<mask_1:4>2)nn1-c1ccccc1<mask_1:4> | 6 | 36 | 4 | 2ccccc | 5 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2cccs2)nn1-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | 2cccs |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(N)=<mask_1:8>CCC3)c(-c2ccccc2)nn1-c1ccccc1<mask_1:8> | 2 | 25 | 8 | O) | 8 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCN(C)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | O)CCN(C) |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccc<mask_1:2>)nn1-c1ccccc1<mask_1:2> | 3 | 40 | 2 | cc2 | 2 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccco2)nn1-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | o2 |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1<mask_1:1>-c1ccccc1<mask_1:1> | 0 | 47 | 1 | 1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1C-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | C |
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<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(N)=O<mask_1:7>c(-c2ccccc2)nn1-c1ccccc1<mask_1:7> | 6 | 26 | 7 | )CCC3) | 7 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCCC3)c(-c2ccccc2)nn1-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | )CCCC3) |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(<mask_1:3>=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1<mask_1:3> | 6 | 18 | 3 | c2C(N) | 3 | Cc1c(C(=O)Nc2sc3c(c2C=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | c2C |
<|startoftext|><L>Cc1c(C(=O)Nc2sc3c(c2C(<mask_1:7>O)CCC3)c(-c2ccccc2)nn1-c1ccccc1<mask_1:7> | 3 | 22 | 7 | N)= | 7 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)C(O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | Cc1c(C(=O)Nc2sc3c(c2C(N)=O)CCC3)c(-c2ccccc2)nn1-c1ccccc1 | N)=O)C( |
<|startoftext|><L>COCc1nc([C@H]2CC[C@@H](O)[C@H](<mask_1:6>3CCOCC3)C2)n(-c2cccnc2)n1<mask_1:6> | 2 | 31 | 6 | NC | 6 | COCc1nc([C@H]2CC[C@@H](O)[C@H](N(C)CC3CCOCC3)C2)n(-c2cccnc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | N(C)CC |
<|startoftext|><L>COCc1<mask_1:5>2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1<mask_1:5> | 8 | 5 | 5 | nc([C@H] | 5 | COCc1nc(CN2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | nc(CN |
<|startoftext|><L>COCc1nc([C@H]<mask_1:5>](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1<mask_1:5> | 8 | 13 | 5 | 2CC[C@@H | 5 | COCc1nc([C@H]2C[C@](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | 2C[C@ |
<|startoftext|><L>COCc1nc([C@H]2CC[C@@H](O)[C@H](N<mask_1:4>COCC3)C2)n(-c2cccnc2)n1<mask_1:4> | 3 | 32 | 4 | C3C | 4 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NCC3CCOCC3)C2)n(-c2cccnc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | CC3C |
<|startoftext|><L>COCc1nc<mask_1:7>C[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1<mask_1:7> | 8 | 7 | 7 | ([C@H]2C | 7 | COCc1nc(CN2CCOC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | (CN2CCO |
<|startoftext|><L>CO<mask_1:5>nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1<mask_1:5> | 3 | 2 | 5 | Cc1 | 5 | COCCCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | CCCc1 |
<|startoftext|><L>COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc<mask_1:4>n1<mask_1:4> | 2 | 54 | 4 | 2) | 4 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2Cl)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | 2Cl) |
<|startoftext|><L>COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2<mask_1:5>)n1<mask_1:5> | 6 | 49 | 5 | cccnc2 | 5 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2ccsc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | ccsc2 |
<|startoftext|><L>COCc1nc([C@H]2CC[<mask_1:7>O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1<mask_1:7> | 6 | 17 | 7 | C@@H]( | 7 | COCc1nc([C@H]2CC[C@@H](CO)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | C@@H](C |
<|startoftext|><L>COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3C<mask_1:3>CC3)C2)n(-c2cccnc2)n1<mask_1:3> | 2 | 35 | 3 | CO | 3 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCCCCC3)C2)n(-c2cccnc2)n1 | COCc1nc([C@H]2CC[C@@H](O)[C@H](NC3CCOCC3)C2)n(-c2cccnc2)n1 | CCC |
<|startoftext|><L>CC<mask_1:4>[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F<mask_1:4> | 0 | 2 | 4 | 4 | CC(C)O[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | (C)O |
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<|startoftext|><L>CC<mask_1:6>C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F<mask_1:6> | 1 | 2 | 6 | [ | 6 | CC(=O)N[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | (=O)N[ |
<|startoftext|><L>CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C<mask_1:2>F)(F)F<mask_1:2> | 1 | 38 | 2 | ( | 2 | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)CC(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | C( |
<|startoftext|><L>CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc<mask_1:2>)C(F)(F)F<mask_1:2> | 4 | 32 | 2 | 1C#N | 2 | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1O)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | 1O |
<|startoftext|><L>CC[C@H](C)[C@@H](NC(=O)<mask_1:5>nH]ncc1C#N)C(F)(F)F<mask_1:5> | 3 | 23 | 5 | c1[ | 5 | CC[C@H](C)[C@@H](NC(=O)NCc1[nH]ncc1C#N)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | NCc1[ |
<|startoftext|><L>CC[C@H](C)[C@@H](NC(=O)<mask_1:2>1[nH]ncc1C#N)C(F)(F)F<mask_1:2> | 1 | 23 | 2 | c | 2 | CC[C@H](C)[C@@H](NC(=O)Nc1[nH]ncc1C#N)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | Nc |
<|startoftext|><L>CC<mask_1:4>[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F<mask_1:4> | 0 | 2 | 4 | 4 | CC(C)O[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | (C)O |
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<|startoftext|><L>CC[C@H](C)[<mask_1:5>NC(=O)c1[nH]ncc1C#N)C(F)(F)F<mask_1:5> | 6 | 11 | 5 | C@@H]( | 5 | CC[C@H](C)[C@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | C@H]( |
<|startoftext|><L>CC[C@H](C)[C@@H](NC(=O)c1<mask_1:5>[nH]ncc1C#N)C(F)(F)F<mask_1:5> | 0 | 25 | 5 | 5 | CC[C@H](C)[C@@H](NC(=O)c1c(=O)[nH]ncc1C#N)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | c(=O) |
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<|startoftext|><L>CC[<mask_1:4>](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F<mask_1:4> | 3 | 3 | 4 | C@H | 4 | CC[C@@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | CC[C@H](C)[C@@H](NC(=O)c1[nH]ncc1C#N)C(F)(F)F | C@@H |
<|startoftext|><L>CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc<mask_1:2>1<mask_1:2> | 6 | 38 | 2 | 2OC)cc | 2 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2)1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | 2) |
<|startoftext|><L>CCOc1ccc([C@H](CC<mask_1:5>O)NC(=O)COc2ccccc2OC)cc1<mask_1:5> | 4 | 17 | 5 | (=O) | 5 | CCOc1ccc([C@H](CC)NC(=O)NC(=O)COc2ccccc2OC)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | )NC(= |
<|startoftext|><L><mask_1:5>1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1<mask_1:5> | 4 | 0 | 5 | CCOc | 5 | CCCCc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | CCCCc |
<|startoftext|><L>CCOc1ccc([C@H](CC(=O)<mask_1:3>O)NC(=O)COc2ccccc2OC)cc1<mask_1:3> | 0 | 21 | 3 | 3 | CCOc1ccc([C@H](CC(=O)NCCO)NC(=O)COc2ccccc2OC)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | NCC |
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<|startoftext|><L>CC<mask_1:5>1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1<mask_1:5> | 2 | 2 | 5 | Oc | 5 | CC(=O)c1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | (=O)c |
<|startoftext|><L>CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2cccc<mask_1:3>cc1<mask_1:3> | 5 | 37 | 3 | c2OC) | 3 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | c2) |
<|startoftext|><L>CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2O<mask_1:4>C)cc1<mask_1:4> | 0 | 40 | 4 | 4 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC(C)C)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | C(C) |
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<|startoftext|><L>CCOc1ccc([C@H](CC(=O)O)NC(=O<mask_1:5>)COc2ccccc2OC)cc1<mask_1:5> | 0 | 28 | 5 | 5 | CCOc1ccc([C@H](CC(=O)O)NC(=O)C(=O)COc2ccccc2OC)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | )C(=O |
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<|startoftext|><L>CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2c<mask_1:5>cc2OC)cc1<mask_1:5> | 2 | 34 | 5 | cc | 5 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccc(C)cc2OC)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | cc(C) |
<|startoftext|><L>CCOc1ccc(<mask_1:5>@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1<mask_1:5> | 2 | 9 | 5 | [C | 5 | CCOc1ccc(CC[C@@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | CCOc1ccc([C@H](CC(=O)O)NC(=O)COc2ccccc2OC)cc1 | CC[C@ |