Copper-mediated C6-selective dehydrogenative heteroarylation of 2-pyridones with 1,3-azoles. 
A copper-mediated C6-selective dehydrogenative heteroarylation of 2-pyridones with 1,3-azoles has been developed.  The reaction proceeded smoothly by twofold C-H cleavage even in the absence of noble-metal catalysts.  The observed site selectivity was directed by a pyridyl substituent on the nitrogen atom of the pyridone ring.  This directing group was readily removed after the coupling event, thus leading to 2-pyridone derivatives with a free N-H group.  Moreover, in some cases, catalytic turnover of the Cu salt was also possible with the ideal terminal oxidant: molecular oxygen in air.