[Suppression of colon cancer in murine model by recombinant human endostatin adenovirus and cisplatin]. 
To investigate the efficacy, side effect and anti-tumor mechanism of recombinant human endostatin adenovirus (Ad-hE) and cisplatin on murine colon cancer.  Mice with CT26 colon cancer were randomly divided into 5 groups, being given Ad-hE via tail vein, cisplatin (Cis) intraperitoneally, Ad-hE plus cisplatin (Ad-hE+Cis), empty adenovirus (Ad-N), and saline (NS), respectively.  The therapeutic effect and side effect of the treatments and the angiogenesis and apoptosis of tumor cells were observed.  Ad-hE + Cis suppressed the growth of lung metastatic tumor and prolonged survival time of the murine CT26 colon cancer model.  The anti-tumor activity was associated with decreased microvessel density and increased apoptosis of tumor cells.  Recombinant human endostatin adenovirus enhances the anti-tumor activity of cisplatin without increasing toxicity.