Survey on the use of smart and adaptive engineering systems in medicine. 
In this paper, the current published knowledge about smart and adaptive engineering systems in medicine is reviewed.  The achievements of frontier research in this particular field within medical engineering are described.  A multi-disciplinary approach to the applications of adaptive systems is observed from the literature surveyed.  The three modalities of diagnosis, imaging and therapy are considered to be an appropriate classification method for the analysis of smart systems being applied to specified medical sub-disciplines.  It is expected that future research in biomedicine should identify subject areas where more advanced intelligent systems could be applied than is currently evident.  The literature provides evidence of hybridisation of different types of adaptive and smart systems with applications in different areas of medical specifications.