Phosphopantothenoylcysteine decarboxylase

In enzymology, a phosphopantothenoylcysteine decarboxylase () is an enzyme that catalyzes the chemical reaction

N-[(R)-4'-phosphopantothenoyl]-L-cysteine  pantotheine 4'-phosphate + CO2

Hence, this enzyme has one substrate, [[N-[(R)-4'-phosphopantothenoyl]-L-cysteine]], and two products, pantotheine 4'-phosphate and CO2. 

This enzyme belongs to the family of lyases, to be specific the carboxy-lyases, which cleave carbon-carbon bonds.   The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming).  Other names in common use include 4-phosphopantotheoylcysteine decarboxylase, 4-phosphopantothenoyl-L-cysteine decarboxylase, PPC-decarboxylase, and N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase.   This enzyme participates in coenzyme A (CoA) biosynthesis from pantothenic acid. 

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and . 

References 

 
 

Category:EC 4.1.1
Category:Enzymes of known structure