Design, synthesis, and pharmacological evaluation of novel oxadiazole and oxadiazoline analogs as anti-inflammatory agents. 
Two novel series of oxadiazole and oxadiazoline analogs possessing an indole nucleus were synthesized for their potential anti-inflammatory activity.  The structures of the compounds were elucidated by elemental and spectral (IR, (1)H-NMR, (13)C-NMR, and MS) analysis.  Most of the test compounds demonstrated appreciable anti-inflammatory activities.  The anti-inflammatory activity of oxadiazoles at doses of 100 mg/kg was shown by their ability to provide 27-66%, 14-32%, and 20-51%.  protection against carrageenan-induced rat paw edema, moist cotton pellet-induced, and dry cotton pellet-induced granuloma, respectively.  On the other hand, the anti-inflammatory properties of oxadiazolines at doses of 100 mg/kg were reflected by their ability to provide 20-56%, 11-26%, and 25-47% protection against carrageenan-induced rat paw edema, moist cotton pellet-induced, and dry cotton pellet-induced granuloma, respectively.  The ulcerogenic potential of the compounds was determined.  Structure-activity relationships among synthesized compounds were also established.