Pulse therapy with 5-FU in eradicating actinic keratoses with less than recommended dosage. 
Pulse therapy has been used for many years, but rarely in a clinical setting.  This article describes a clinical study designed to determine the efficacy of pulse therapy with 5-FU for patients with multiple actinic keratoses.  The results indicated that pulse therapy was indeed effective in eradicating most of the actinic keratoses while causing less discomfort or disfigurement than the FDA recommended dose, especially for patients with less severe and milder forms of actinic keratoses.