Chip-based electrochromatography coupled to ESI-MS detection. 
In this study, we present the coupling of chip-based electrochromatography to MS using a glass chip with a monolithically integrated nanoelectrospray emitter.  As separation column, an acrylate-based porous polymer monolith is implemented into the glass chip by photopolymerization.  For the establishment and development of this method, we used a test mixture detectable with both fluorescence and ESI-MS.  After successful evaluation of the approach with the test solutes, it was applied exemplarily for drug analysis such as high-speed separations of benzodiazepines in pharmaceuticals.