Prevention of cardiovascular disease--opportunities for progress. 
Steady progress has been made in the prevention of cardiovascular disease.  There has been a favorable trend in major risk factor reduction and an average 3% annual decline in cardiovascular disease death rates over the past decade.  Yet, CVD death rates still exceed that for many countries and not all segments of the U.S. population have benefited equally.  Cardiovascular disease remains the leading cause of death and disability in this country.  The role of epidemiologic research and prevention strategies in addressing this issue has been underestimated.  Unresolved research questions require further epidemiologic research in order to improve application of known preventive measures and explore other approaches toward the prevention of cardiovascular disease.  It is well established that attention to life-style changes and pharmacologic approaches can prevent cardiovascular disease in those at high risk and reduce the likelihood of subsequent cardiac events among patients with known cardiovascular disease.  Furthermore, small changes in the distribution of risk factors through community intervention can have tremendous impact on cardiovascular disease morbidity and mortality.  Preventive research requires an appropriate framework and plan to satisfy or exceed the needs in keeping with the national goals for Healthy People 2000.  The National Heart, Lung, and Blood Institute has addressed this issue by creating a Task Force to develop research priorities for epidemiology and prevention.