[TEMPORAL ORDER DETERIORATION AND CIRCADIAN DISRUPTION WITH AGE]. 
The present review summarizes the current knowledge of gradual deterioration of temporal order in aging humans and other mammals.  An obvious consequence of age-dependent circadian disruption in complex mechanisms is extra-circadian dissemination (ECD) that can be observed in overt rhythmic functions.  ECD is a variance transposition from circadian to ultradian and infradian frequencies accompanied by a loss of interdaily phase stability.  Moreover, heterochronic changes in central and peripheral tissue-specific cellular mechanisms are involved in circadian desychronization.  A multitude of internal factors accounts for cumulative clockwork misalignment.  Age-related circadian disruption is a consequence of weaker rhythm generation and the loss of proper orchestration on molecular, tissue and systemic levels, disabling their circadian synchrony and resonance.