Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus. 
An Aspergillus fumigatus extracellular alkaline protease (ALP) which is an enzyme of the subtilisin family is a potential virulent factor of the fungus.  The gene encoding ALP was isolated from a genomic library made from DNA of an A. fumigatus isolate.  The nucleotide sequence of this gene was compared to that of a cDNA encoding A. oryzae ALP and to that of a cDNA from A. fumigatus encoding the mature ALP protein.  Mature A. fumigatus ALP contains 282 amino acids and is encoded by three exons.  The pre-proenzyme has a leader sequence of 121 amino acids.