Successful sodium thiosulphate treatment for recurrent calcium urolithiasis. 
Thirty-four idiopathic rapid calcium stone formers (24 male/10 female) were studied.  Their ages ranged from 20 to 60 years (40 +/- 11) and all had good renal function.  The trial comprised two consecutive periods of 3 years and 4 years duration respectively.  In the first (control period), the patients were maintained on a customary diet with an adequate fluid intake sufficient to produce about 2 liters of urine daily.  In the second (treatment period), they received a similar diet plus 20 mmol of sodium thiosulphate daily.  New stone development fell from 100 in the control period to 15 in the treatment period, corresponding to a rate of 0.98 and 0.11 per year (p less than 0.001).  It is suggested that the benefit from sodium thiosulphate results from calcium thiosulphate formation in urine, a salt with a molar solubility of 250 to 100.000-fold greater than that of other urinary calcium salts.