[Prolactin producing adenomas of the pituitary gland with primary localization in the sinus sphenoidalis (author's transl)]. 
The radio-immuno-assay of the pituitary hormone prolactin represents the basis for a functional differentiation of the so-called chromophobic adenomas.  Two thirds of these tumors produce this hormone.  For a long period of growth these adenomas are localized in the middle of the sella turcica.  Their first direction of growth is towards the sinus sphenoidalis.  At the ENT-clinic of the Cologne University two prolactin producing adenomas have been detected as the cause of suspected changes of the sinus sphenoidalis.  The need for an endocrinological diagnosis in cases of unknown processes of the sinus sphenoidalis, the indication for surgery, and the medicamental treatment of these tumors with 2-Br-alpha-Ergocriptine (Parlodel) is discussed.