A study to evaluate the efficacy of image-guided core biopsy in the diagnosis and management of lymphoma--results in 103 biopsies. 
The reason for this study was to evaluate the ability of image-guided core biopsy to replace surgical excision by providing sufficient diagnostic and treatment information.  All consecutive image-guided core biopsies in patients with a final diagnosis of lymphoma over a 6-year period at our institution were collected retrospectively.  Case notes and pathology reports were reviewed and the diagnostic techniques used were recorded.  Pathology reports were graded according to their diagnostic completeness and their ability to provide treatment information.  Out of a total of 328 instances of lymphoma, 103 image-guided core biopsies were performed in 96 patients.  In 78% of these, the diagnostic information obtained from the biopsy provided a fully graded and subtyped diagnosis of lymphoma with sufficient information to initiate therapy.  In the head and neck 67% of core biopsies were fully diagnostic for treatment purposes compared to 91% in the thorax, abdomen and pelvis.  Image-guided core biopsy has a number of cost and safety advantages over surgical excision biopsy and in suitable cases it can obviate the need for surgery in cases of suspected lymphoma.  This is especially relevant for elderly patients and those with poor performance status.