Glass-reinforced hydroxyapatite composites: secondary phase proportions and densification effects on biaxial bending strength. 
CaO-P(2)O(5) glasses with additions of MgO and CaF(2) were used as a sintering aid of hydroxyapatite, and glass-reinforced hydroxyapatite composites obtained.  Glasses promoted significant changes in the microstructure of the composites, namely with the formation of tricalcium phosphate secondary phases, beta and alpha-TCP.  Quantitative phase analysis was performed by the Rietveld method using General Structure Analysis Software.  Grain size measurements were carried out on SEM photomicrographs, using a planimetric procedure according to ASTM E 112-88.  Flexural bending strength was determined from concentric ring-on-ring testing.  Flexural bending strength (FBS) of glass-reinforced hydroxyapatite composites was found to be about twice or three times higher than that of unreinforced hydroxyapatite and tended to depend more on porosity and beta and alpha-TCP secondary phases, rather than on grain size.  Traces of alpha-tricalcium phosphate significantly enhanced the strength of the composites.  Using the rule of mixtures to estimate the zero porosity bending strength, the Duckworth-Knudsen model applied to the composites gave a porosity correction factor, b, with a value of 4.02.  Weibull statistics were also used to analyze biaxial strength data and the level of reinforcement obtained by comparing failure probability for the composites and for the unreinforced hydroxyapatite.  Lower activation energies for grain growth were observed for the composites compared to unreinforced hydroxyapatite, which should be attributed to the presence of a liquid glassy phase that promotes atomic diffusion during the sintering process.