Development of formulation device for periodontal disease. 
In addition to providing standard surgical treatment that removes the plaque and infected tissues, medications that can regenerate periodontal tissue are also required in the treatment of periodontal disease.  As a form of regenerative medication, various growth factors are expected to be used while treating periodontal disease.  A protein-like growth factor is often developed as a lyophilized product with dissolution liquid, considering its instability in the solution state.  We have clarified that the formulation for periodontal disease needs to be viscous.  When the lyophilized product was dissolved using a sticky solution, various problems were encountered, difficulty in dissolving and air bubbles, for example, and some efforts were needed to prepare the formulation.  In this research, to identify the problem of preparing a viscous formulation, a lyophilized product (placebo) and sticky liquid were prepared by using vial and ampoule as the conventional containers.  Based on these problems, a prototype administration device was developed, and its functionality was confirmed.  As a result, it was suggested that the device with a useful mixing system that could shorten the preparation time was developed.