Assessment of efficacy and adverse effects of trazodone in the treatment of major depressive disorder. 
Major depressive disorder is a serious and disabling illness in the world and is common chronic and recurrent disorder.  It is the fourth most important cause of worldwide loss in disability.  This was prospective and open-label study, study conducted in JPMC.  Karachi, to evaluate the efficacy and adverse effects in major depressive disorder individuals.  A total of 40 patients irrespective of the gender, aged 18 years up to 65 years were enrolled from OPD of Psychiatry Department.  Follow-up visits were carried out fortnightly after making evaluation of symptoms at baseline visit (day 0), follow-up continued till 90 days when the results were compiled.  Statistically significant (p < 0.05) results were observed in all the parameters at the end of study, i.e., day 90.  Among all the symptoms of major depressive disorder, trazodone proved to be more effective in controlling insomnia.