Utility of lower limb positive pressure test for diagnosis of diastolic heart failure: a case report. 
A 70-year-old woman with dyspnea on exertion was admitted to our hospital.  She had a history of apical hypertrophic cardiomyopathy (HCM) and repeated hospitalization for heart failure.  Results of physical examination were normal except for leg edema.  Echocardiography showed apical HCM with preserved LV systolic function (LVEF=70%).  Although dyspnea on exertion and leg edema improved rapidly with the use of diuretics, her symptoms soon worsened when daily activity was started again.  In order to examine the effect of preload on hemodynamics, we performed a lower limb positive pressure test by compressing both legs using a household air leg massager.  Echocardiography showed increases in mitral E velocity, E/A ratio and pulmonary venous D flow as well as decrease in stroke volume during the lower limb positive pressure test.  Simultaneously-recorded pressure study also showed elevated LVEDP and increased v wave of pulmonary capillary wedge pressure.  These results suggested that even a small increase in preload led to elevation of LVEDP and symptomatic worsening due to severe diastolic heart failure in the present case.  The lower limb positive pressure test may be useful for assessing the effect of preload on hemodynamics in patients with diastolic heart failure.