Strategies for Selecting the Optimal Treatment in Newly Diagnosed Multiple Myeloma Patients. 
To review the current evidence on strategies for selecting the optimal treatment for newly diagnosed patients with multiple myeloma (MM).  Journal articles, research reports, state of the science papers, and clinical practice guidelines.  Despite the plethora of drugs to effectively treat MM, the optimal induction regimen for patients with newly diagnosed MM is unknown.  Rapid control of the disease, appropriate treatment selection and effective supportive care strategies remain integral to prevention and management of the disease.  Strategies for selecting the optimal treatment include considering inherent patient characteristics, frailty, and existing clinical practice guidelines.  Nurses should provide patients with disease- and treatment-related education to enhance patient and caregiver understanding of the disease and treatment options, taking into consideration clinical data and overarching goals of treatment.