Cell type specificity and mechanism of control of a gene may be reverted in different strains of Dictyostelium discoideum. 
Twelve genes which are expressed exclusively in pre-spore cells of Dictyostelium strain AX3 are expressed exclusively in pre-stalk cells of strain AX2.  One gene has the opposite behavior: it is expressed in pre-stalk cells in AX3 and in pre-spore cells in AX2.  The change in cell type specificity involves a change in the mechanism of control of gene expression.  When they are expressed in pre-stalk cells, genes are controlled at the level of transcription, whilst in pre-spore cells, they are controlled at the level of mRNA stability.  Genes expressed in pre-stalk cells in strain AX2, fused with an AX2 pre-spore specific promoter, become regulated at the level of mRNA stability.  These findings indicate that at least a group of pre-stalk mRNAs possess the cis-destabilizing element typical of pre-spore mRNAs, though they are not destabilized in disaggregated cells.  This is due to the fact that ribosomal protein S6, phosphorylation of which is responsible for controlling the stability of pre-spore mRNAs, is not dephosphorylated in disaggregated pre-stalk cells.  These cells lack an S6 phosphatase activity which has been purified from disaggregated pre-spore cells.