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<table-wrap><label>Table 3</label><caption><title>Antiproliferative Activity of Compounds 12, 26, 31, 35, 36, 38, 44–46, 60, Colchicine, Paclitaxel, and Vinblastine on CHO, K562, L1210, P388D1, B16F0, DU-145, HT-1080, MDA-MB-231, SKOV3, and CEM Cells</title></caption><table><colgroup><col/><col/><col/><col/><col/><col/><col/><col/><col/><col/><col/></colgroup><thead> <tr> <th> </th> <th colspan="10">IC50 (nM)d<hr/></th> </tr> <tr> <th>compd</th> <th>CHO</th> <th>K562</th> <th>L1210</th> <th>P388D1</th> <th>B16F0</th> <th>DU 145</th> <th>HT-1080</th> <th>MDA-MB-231</th> <th>SKOV3</th> <th>CEM</th> </tr></thead><tbody> <tr> <td>12</td> <td>240</td> <td>240</td> <td>250</td> <td>260</td> <td>510</td> <td>650</td> <td>240</td> <td>760</td> <td>320</td> <td>250</td> </tr> <tr> <td>26</td> <td>18</td> <td>18</td> <td>21</td> <td>19</td> <td>49</td> <td>57</td> <td>24</td> <td>69</td> <td>29</td> <td>19</td> </tr> <tr> <td>31</td> <td>73</td> <td>65</td> <td>67</td> <td>76</td> <td>91</td> <td>170</td> <td>65</td> <td>100</td> <td>72</td> <td>68</td> </tr> <tr> <td>35</td> <td>32</td> <td>18</td> <td>19</td> <td>20</td> <td>65</td> <td>72</td> <td>34</td> <td>55</td> <td>42</td> <td>20</td> </tr> <tr> <td>36</td> <td>18</td> <td>16</td> <td>17</td> <td>19</td> <td>46</td> <td>58</td> <td>19</td> <td>45</td> <td>22</td> <td>17</td> </tr> <tr> <td>38</td> <td>17</td> <td>14</td> <td>19</td> <td>18</td> <td>30</td> <td>57</td> <td>19</td> <td>48</td> <td>23</td> <td>17</td> </tr> <tr> <td>44</td> <td>7.3</td> <td>7.5</td> <td>6.4</td> <td>7.8</td> <td>25</td> <td>25</td> <td>8.2</td> <td>14</td> <td>6.8</td> <td>7.1</td> </tr> <tr> <td>45</td> <td>7.4</td> <td>2.5</td> <td>5.4</td> <td>2.7</td> <td>9.2</td> <td>8.5</td> <td>5.9</td> <td>9.4</td> <td>6.1</td> <td>7.1</td> </tr> <tr> <td>46</td> <td>17</td> <td>7.2</td> <td>9.6</td> <td>7.4</td> <td>41</td> <td>66</td> <td>18</td> <td>26</td> <td>16</td> <td>16</td> </tr> <tr> <td>60</td> <td>230</td> <td>180</td> <td>140</td> <td>240</td> <td>250</td> <td>550</td> <td>190</td> <td>360</td> <td>210</td> <td>200</td> </tr> <tr> <td>Cola</td> <td>220</td> <td>6.8</td> <td>6.9</td> <td>28</td> <td>13</td> <td>10</td> <td>1.1</td> <td>2.9</td> <td>2.1</td> <td>7.9</td> </tr> <tr> <td>Pacb</td> <td>170</td> <td>0.71</td> <td>0.40</td> <td>35</td> <td>28</td> <td>1.3</td> <td>0.15</td> <td>9.1</td> <td>2.6</td> <td>0.27</td> </tr> <tr> <td>Vblc</td> <td>17</td> <td>0.36</td> <td>0.16</td> <td>1.8</td> <td>0.099</td> <td>0.063</td> <td>0.099</td> <td>0.12</td> <td>0.039</td> <td>0.38</td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>Col, colchicine.</p></fn><fn><label>b</label><p>Pac, paclitaxel.</p></fn><fn><label>c</label><p>Vbl, vinblastine.</p></fn><fn><label>d</label><p>IC50: concentration of drug inhibiting cell growth by 50%.</p></fn></table-wrap-foot></table-wrap>
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{ "cell_index": [ "CA(2,0)", "CA(2,1)", "CA(2,2)", "CA(2,3)", "CA(2,4)", "CA(2,5)", "CA(2,6)", "CA(2,7)", "CA(2,8)", "CA(2,9)", "CA(2,10)", "CA(3,0)", "CA(3,1)", "CA(3,2)", "CA(3,3)", "CA(3,4)", "CA(3,5)", "CA(3,6)", "CA(3,7)", "CA(3,8)", "CA(3,9)", "CA(3,10)", "CA(4,0)", "CA(4,1)", "CA(4,2)", "CA(4,3)", "CA(4,4)", "CA(4,5)", "CA(4,6)", "CA(4,7)", "CA(4,8)", "CA(4,9)", "CA(4,10)", "CA(5,0)", "CA(5,1)", "CA(5,2)", "CA(5,3)", "CA(5,4)", "CA(5,5)", "CA(5,6)", "CA(5,7)", "CA(5,8)", "CA(5,9)", "CA(5,10)", "CA(6,0)", "CA(6,1)", "CA(6,2)", "CA(6,3)", "CA(6,4)", "CA(6,5)", "CA(6,6)", "CA(6,7)", "CA(6,8)", "CA(6,9)", "CA(6,10)", "CA(7,0)", "CA(7,1)", "CA(7,2)", "CA(7,3)", "CA(7,4)", "CA(7,5)", "CA(7,6)", "CA(7,7)", "CA(7,8)", "CA(7,9)", "CA(7,10)", "CA(8,0)", "CA(8,1)", "CA(8,2)", "CA(8,3)", "CA(8,4)", "CA(8,5)", "CA(8,6)", "CA(8,7)", "CA(8,8)", "CA(8,9)", "CA(8,10)", "CA(9,0)", "CA(9,1)", "CA(9,2)", "CA(9,3)", "CA(9,4)", "CA(9,5)", "CA(9,6)", "CA(9,7)", "CA(9,8)", "CA(9,9)", "CA(9,10)", "CA(10,0)", "CA(10,1)", "CA(10,2)", "CA(10,3)", "CA(10,4)", "CA(10,5)", "CA(10,6)", "CA(10,7)", "CA(10,8)", "CA(10,9)", "CA(10,10)", "CA(11,0)", "CA(11,1)", "CA(11,2)", "CA(11,3)", "CA(11,4)", "CA(11,5)", "CA(11,6)", "CA(11,7)", "CA(11,8)", "CA(11,9)", "CA(11,10)", "CA(12,1)", "CA(12,2)", "CA(12,3)", "CA(12,4)", "CA(12,5)", "CA(12,6)", "CA(12,7)", "CA(12,8)", "CA(12,9)", "CA(12,10)", "CA(13,1)", "CA(13,2)", "CA(13,3)", "CA(13,4)", "CA(13,5)", "CA(13,6)", "CA(13,7)", "CA(13,8)", "CA(13,9)", "CA(13,10)", "CA(14,1)", "CA(14,2)", "CA(14,3)", "CA(14,4)", "CA(14,5)", "CA(14,6)", "CA(14,7)", "CA(14,8)", "CA(14,9)", "CA(14,10)" ], "cell_record": [ "{\"value\": \"12\", \"type\": \"Other\"}", "{\"value\": \"240\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"12\", \"unit\": \"nM\"}", "{\"value\": \"240\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"12\", \"unit\": \"180\"}", "{\"value\": \"250\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"12\", \"unit\": 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"{\"value\": \"21\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}", "{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}", "{\"value\": \"49\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}", "{\"value\": \"57\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}", "{\"value\": \"24\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}", "{\"value\": \"69\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}", "{\"value\": \"29\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}", "{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"26\", \"unit\": \"nM\"}", "{\"value\": \"31\", \"type\": \"Other\"}", "{\"value\": \"73\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"65\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"67\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"76\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"91\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"170\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"65\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"100\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"72\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"68\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"35\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"65\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"72\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"34\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"55\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"42\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"36\", \"type\": \"Other\"}", "{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"16\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"46\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"58\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"45\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"22\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"36\", \"unit\": \"nM\"}", "{\"value\": \"38\", \"type\": \"Other\"}", "{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"14\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"30\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"57\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"48\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"23\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"38\", \"unit\": \"nM\"}", "{\"value\": \"44\", \"type\": \"Other\"}", "{\"value\": \"7.3\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"7.5\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"6.4\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"7.8\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"25\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"25\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"8.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"14\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"6.8\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"7.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"45\", \"type\": \"Other\"}", "{\"value\": \"7.4\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"2.5\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"5.4\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"2.7\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"9.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"8.5\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"5.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"9.4\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"6.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"7.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"46\", \"type\": \"Other\"}", "{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"7.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"9.6\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"7.4\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"41\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"66\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"18\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"26\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"16\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"16\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"60\", \"type\": \"Other\"}", "{\"value\": \"230\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"180\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"140\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"240\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"250\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"550\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"190\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"360\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"210\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"200\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"220\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"6.8\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"6.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"28\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"13\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"10\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"1.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"2.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"2.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"7.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"170\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"0.71\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"0.40\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"35\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"28\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"1.3\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"0.15\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"9.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"2.6\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"0.27\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"17\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.36\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.16\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"1.8\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.099\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.063\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.099\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.12\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.039\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.38\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}" ] }
PMC3131785
tbl4
<table-wrap><label>Table 4</label><caption><title>Antiproliferative Activity of Compounds 12, 26, 31, 35, 36, 38, 44–46, 60, Colchicine, Paclitaxel, and Vinblastine on Chemoresistant TAX 5-6, CHO-VV 3-2, and CEM-VLB Cells</title></caption><table><colgroup><col/><col/><col/><col/><col/><col/><col/></colgroup><thead> <tr> <th>compd</th> <th>IC50 (nM)dCHO-TAX 5-6e</th> <th>ratio resistant/wild-typeCHO-TAX 5-6/CHO</th> <th>IC50 (nM)dCHO-VV 3-2f</th> <th>ratio resistant/wild-typeCHO-VV 3-2/CHO</th> <th>IC50 (nM)dCEM-VLBg</th> <th>ratio resistant/wild-typeCEM-VLB/CEM</th> </tr></thead><tbody> <tr> <td>12</td> <td>200</td> <td>0.83</td> <td>250</td> <td>1.0</td> <td>320</td> <td>1.3</td> </tr> <tr> <td>26</td> <td>14</td> <td>0.78</td> <td>21</td> <td>1.2</td> <td>23</td> <td>1.2</td> </tr> <tr> <td>31</td> <td>38</td> <td>0.52</td> <td>74</td> <td>1.0</td> <td>87</td> <td>1.3</td> </tr> <tr> <td>35</td> <td>12</td> <td>0.38</td> <td>39</td> <td>1.2</td> <td>32</td> <td>1.6</td> </tr> <tr> <td>36</td> <td>9.3</td> <td>0.52</td> <td>20</td> <td>1.1</td> <td>20</td> <td>1.2</td> </tr> <tr> <td>38</td> <td>8.9</td> <td>0.52</td> <td>20</td> <td>1.2</td> <td>18</td> <td>1.1</td> </tr> <tr> <td>44</td> <td>5.2</td> <td>0.71</td> <td>15</td> <td>2.1</td> <td>9.2</td> <td>1.3</td> </tr> <tr> <td>45</td> <td>3</td> <td>0.41</td> <td>8.2</td> <td>1.1</td> <td>9.5</td> <td>1.3</td> </tr> <tr> <td>46</td> <td>6.1</td> <td>0.36</td> <td>20</td> <td>1.2</td> <td>19</td> <td>1.2</td> </tr> <tr> <td>60</td> <td>86</td> <td>0.37</td> <td>260</td> <td>1.1</td> <td>270</td> <td>1.4</td> </tr> <tr> <td>Cola</td> <td>140</td> <td>0.64</td> <td>620</td> <td>2.8</td> <td>360</td> <td>46</td> </tr> <tr> <td>Pacb</td> <td>520</td> <td>3.1</td> <td>140</td> <td>0.82</td> <td>3340</td> <td>12370</td> </tr> <tr> <td>Vblc</td> <td>6.9</td> <td>0.41</td> <td>66</td> <td>3.9</td> <td>600</td> <td>1579</td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>Col, colchicine.</p></fn><fn><label>b</label><p>Pac, paclitaxel.</p></fn><fn><label>c</label><p>Vbl, vinblastine.</p></fn><fn><label>d</label><p>IC50: concentration of drug inhibiting cell growth by 50%.</p></fn><fn><label>e</label><p>Paclitaxel-resistant CHO-TAX 5-6 cells.</p></fn><fn><label>f</label><p>Colchicine-and vinblastine-resistant CHO-VV 3-2 cells.</p></fn><fn><label>g</label><p>Multidrug-resistant leukemia CEM-VLB cells.</p></fn></table-wrap-foot></table-wrap>
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{ "cell_index": [ "CA(1,0)", "CA(1,1)", "CA(1,2)", "CA(1,3)", "CA(1,4)", "CA(1,5)", "CA(1,6)", "CA(2,0)", "CA(2,1)", "CA(2,2)", "CA(2,3)", "CA(2,4)", "CA(2,5)", "CA(2,6)", "CA(3,0)", "CA(3,1)", "CA(3,2)", "CA(3,3)", "CA(3,4)", "CA(3,5)", "CA(3,6)", "CA(4,0)", "CA(4,1)", "CA(4,2)", "CA(4,3)", "CA(4,4)", "CA(4,5)", "CA(4,6)", "CA(5,0)", "CA(5,1)", "CA(5,2)", "CA(5,3)", "CA(5,4)", "CA(5,5)", "CA(5,6)", "CA(6,0)", "CA(6,1)", "CA(6,2)", "CA(6,3)", "CA(6,4)", "CA(6,5)", "CA(6,6)", "CA(7,0)", "CA(7,1)", "CA(7,2)", "CA(7,3)", "CA(7,4)", "CA(7,5)", "CA(7,6)", "CA(8,0)", "CA(8,1)", "CA(8,2)", "CA(8,3)", "CA(8,4)", "CA(8,5)", "CA(8,6)", "CA(9,0)", "CA(9,1)", "CA(9,2)", "CA(9,3)", "CA(9,4)", "CA(9,5)", "CA(9,6)", "CA(10,0)", "CA(10,1)", "CA(10,2)", "CA(10,3)", "CA(10,4)", "CA(10,5)", "CA(10,6)", "CA(11,1)", "CA(11,2)", "CA(11,3)", "CA(11,4)", "CA(11,5)", "CA(11,6)", "CA(12,1)", "CA(12,2)", "CA(12,3)", "CA(12,4)", "CA(12,5)", "CA(12,6)", "CA(13,1)", "CA(13,2)", "CA(13,3)", "CA(13,4)", "CA(13,5)", 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\"type\": \"Other\"}", "{\"value\": \"31\", \"type\": \"Other\"}", "{\"value\": \"38\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"0.52\", \"type\": \"Other\"}", "{\"value\": \"74\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"1.0\", \"type\": \"Other\"}", "{\"value\": \"87\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"31\", \"unit\": \"nM\"}", "{\"value\": \"1.3\", \"type\": \"Other\"}", "{\"value\": \"35\", \"type\": \"Other\"}", "{\"value\": \"12\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"0.38\", \"type\": \"Other\"}", "{\"value\": \"39\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"1.2\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"nM\"}", "{\"value\": \"1.6\", \"type\": 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"{\"value\": \"44\", \"type\": \"Other\"}", "{\"value\": \"5.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"0.71\", \"type\": \"Other\"}", "{\"value\": \"15\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"2.1\", \"type\": \"Other\"}", "{\"value\": \"9.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"44\", \"unit\": \"nM\"}", "{\"value\": \"1.3\", \"type\": \"Other\"}", "{\"value\": \"45\", \"type\": \"Other\"}", "{\"value\": \"3\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"0.41\", \"type\": \"Other\"}", "{\"value\": \"8.2\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"1.1\", \"type\": \"Other\"}", "{\"value\": \"9.5\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"45\", \"unit\": \"nM\"}", "{\"value\": \"1.3\", \"type\": \"Other\"}", "{\"value\": \"46\", \"type\": \"Other\"}", "{\"value\": \"6.1\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"0.36\", \"type\": \"Other\"}", "{\"value\": \"20\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"1.2\", \"type\": \"Other\"}", "{\"value\": \"19\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"46\", \"unit\": \"nM\"}", "{\"value\": \"1.2\", \"type\": \"Other\"}", "{\"value\": \"60\", \"type\": \"Other\"}", "{\"value\": \"86\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"0.37\", \"type\": \"Other\"}", "{\"value\": \"260\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"1.1\", \"type\": \"Other\"}", "{\"value\": \"270\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"60\", \"unit\": \"nM\"}", "{\"value\": \"1.4\", \"type\": \"Other\"}", "{\"value\": \"140\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"0.64\", \"type\": \"Other\"}", "{\"value\": \"620\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"2.8\", \"type\": \"Other\"}", "{\"value\": \"360\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Cola\", \"unit\": \"nM\"}", "{\"value\": \"46\", \"type\": \"Other\"}", "{\"value\": \"520\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"3.1\", \"type\": \"Other\"}", "{\"value\": \"140\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"0.82\", \"type\": \"Other\"}", "{\"value\": \"3340\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Pacb\", \"unit\": \"nM\"}", "{\"value\": \"12370\", \"type\": \"Other\"}", "{\"value\": \"6.9\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"0.41\", \"type\": \"Other\"}", "{\"value\": \"66\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"3.9\", \"type\": \"Other\"}", "{\"value\": \"600\", \"type\": \"IC50\", \"target\": \"xx\", \"treatment\": \"Vblc\", \"unit\": \"nM\"}", "{\"value\": \"1579\", \"type\": \"Other\"}" ] }
PMC3910272
tbl3
<table-wrap><label>Table 3</label><caption><title>IC50 Values (μM) for a Panel of Metallo-β-lactamasesa</title></caption><table><colgroup><col/><col/><col/><col/><col/><col/></colgroup><thead> <tr> <th>MBL</th> <th>(S)-7d</th> <th>(R)-7d</th> <th>MBL</th> <th>(S)-7d</th> <th>(R)-7d</th> </tr></thead><tbody> <tr> <td>SPM-1</td> <td>23.2 ± 1.1</td> <td>46.6 ± 1.1</td> <td>VIM-2</td> <td>54.7 ± 1.4</td> <td>55.3 ± 1.3</td> </tr> <tr> <td>IMP-1</td> <td>75.6 ± 1.5</td> <td>74.1 ± 1.6</td> <td>Bc II</td> <td>61.3 ± 1.3</td> <td>132.4 ± 1.3</td> </tr> <tr> <td>NDM-1</td> <td>61.4 ± 1.3</td> <td>47.1 ± 1.1</td> <td> </td> <td> </td> <td> </td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>IC50 determinations were performed in duplicate over a range of 0.25–200 μM.</p></fn></table-wrap-foot></table-wrap>
{ "cell_value": [ "23.2", "46.6", "54.7", "55.3", "75.6", "74.1", "61.3", "132.4", "61.4", "47.1" ], "cell_raw": [ "23.2 ± 1.1", "46.6 ± 1.1", "54.7 ± 1.4", "55.3 ± 1.3", "75.6 ± 1.5", "74.1 ± 1.6", "61.3 ± 1.3", "132.4 ± 1.3", "61.4 ± 1.3", "47.1 ± 1.1" ], "cell_index": [ "CA(1,1)", "CA(1,2)", "CA(1,4)", "CA(1,5)", "CA(2,1)", "CA(2,2)", "CA(2,4)", "CA(2,5)", "CA(3,1)", "CA(3,2)" ], "cell_row_idx": [ 1, 1, 1, 1, 2, 2, 2, 2, 3, 3 ], "cell_col_idx": [ 1, 2, 4, 5, 1, 2, 4, 5, 1, 2 ] }
{ "cell_index": [ "CA(1,1)", "CA(1,2)", "CA(1,4)", "CA(1,5)", "CA(2,1)", "CA(2,2)", "CA(2,4)", "CA(2,5)", "CA(3,1)", "CA(3,2)" ], "cell_record": [ "{\"value\": \"23.2\", \"type\": \"IC50\", \"target\": \"SPM-1\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}", "{\"value\": \"46.6\", \"type\": \"IC50\", \"target\": \"SPM-1\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}", "{\"value\": \"54.7\", \"type\": \"IC50\", \"target\": \"VIM-2\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}", "{\"value\": \"55.3\", \"type\": \"IC50\", \"target\": \"VIM-2\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}", "{\"value\": \"75.6\", \"type\": \"IC50\", \"target\": \"IMP-1\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}", "{\"value\": \"74.1\", \"type\": \"IC50\", \"target\": \"IMP-1\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}", "{\"value\": \"61.3\", \"type\": \"IC50\", \"target\": \"Bc II\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}", "{\"value\": \"132.4\", \"type\": \"IC50\", \"target\": \"Bc II\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}", "{\"value\": \"61.4\", \"type\": \"IC50\", \"target\": \"NDM-1\", \"treatment\": \"(S)-7d\", \"unit\": \"μM\"}", "{\"value\": \"47.1\", \"type\": \"IC50\", \"target\": \"NDM-1\", \"treatment\": \"(R)-7d\", \"unit\": \"μM\"}" ] }
PMC4018117
tbl2
<table-wrap><label>Table 2</label><caption><title>MRC and GI50 Values for the Substitutions of Indoline Aromatic Ring</title></caption><graphic></graphic><table><colgroup><col/><col/><col/><col/><col/><col/><col/><col/><col/><col/></colgroup><thead> <tr> <th>entry</th> <th>compd</th> <th>R1</th> <th>R2</th> <th>R3</th> <th>R4</th> <th>amox/clava,b</th> <th>cefazolina,b</th> <th>meropenema,c</th> <th>GI50d</th> </tr></thead><tbody> <tr> <td>1</td> <td>1</td> <td>H</td> <td>Br</td> <td>H</td> <td>H</td> <td>4</td> <td>4</td> <td>4</td> <td>17.1</td> </tr> <tr> <td>2</td> <td>6a</td> <td>H</td> <td>Cl</td> <td>H</td> <td>H</td> <td>8</td> <td>4</td> <td>8</td> <td>35</td> </tr> <tr> <td>3</td> <td>6b</td> <td>H</td> <td>Me</td> <td>H</td> <td>H</td> <td>16</td> <td>16</td> <td>32</td> <td>–</td> </tr> <tr> <td>4</td> <td>6c</td> <td>H</td> <td>MeO</td> <td>H</td> <td>H</td> <td>>32</td> <td>>32</td> <td>>32</td> <td>–</td> </tr> <tr> <td>5</td> <td>6d</td> <td>H</td> <td>F</td> <td>H</td> <td>H</td> <td>16</td> <td>16</td> <td>16</td> <td>–</td> </tr> <tr> <td>6</td> <td>6e</td> <td>H</td> <td>H</td> <td>H</td> <td>H</td> <td>16</td> <td>16</td> <td>16</td> <td>–</td> </tr> <tr> <td>7</td> <td>6f</td> <td>H</td> <td>H</td> <td colspan="2">phenylene</td> <td>>32</td> <td>>32</td> <td>>32</td> <td>–</td> </tr> <tr> <td>8</td> <td>6g</td> <td>H</td> <td>H</td> <td>H</td> <td>Br</td> <td>>32</td> <td>32</td> <td>8</td> <td>–</td> </tr> <tr> <td>9</td> <td>6h</td> <td>H</td> <td>H</td> <td>Br</td> <td>H</td> <td>16</td> <td>16</td> <td>16</td> <td>–</td> </tr> <tr> <td>10</td> <td>6i</td> <td>Br</td> <td>H</td> <td>H</td> <td>H</td> <td>32</td> <td>16</td> <td>16</td> <td>–</td> </tr> <tr> <td>11</td> <td>6j</td> <td>H</td> <td>Cl</td> <td>H</td> <td>F</td> <td>16</td> <td>16</td> <td>32</td> <td>–</td> </tr> <tr> <td>12</td> <td>6k</td> <td>H</td> <td>Cl</td> <td>H</td> <td>Cl</td> <td>4</td> <td>4</td> <td>4</td> <td>13.6</td> </tr> <tr> <td>13</td> <td>6l</td> <td>H</td> <td>Br</td> <td>H</td> <td>F</td> <td>2</td> <td>4</td> <td>4</td> <td>18.1</td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>MRC values are in μg/mL.</p></fn><fn><label>b</label><p>MRSA ATCC BAA-44.</p></fn><fn><label>c</label><p>MRSA ATCC 33592.</p></fn><fn><label>d</label><p>HeLa cells; GI50 values are in μg/mL.</p></fn></table-wrap-foot></table-wrap>
{ "cell_value": [ "1", "1", "4", "4", "4", "17.1", "2", "8", "4", "8", "35", "3", "16", "16", "32", "4", "32", "32", "32", "5", "16", "16", "16", "6", "16", "16", "16", "7", "32", "32", "32", "8", "32", "32", "8", "9", "16", "16", "16", "10", "32", "16", "16", "11", "16", "16", "32", "12", "4", "4", "4", "13.6", "13", "2", "4", "4", "18.1" ], "cell_raw": [ "1", "1", "4", "4", "4", "17.1", "2", "8", "4", "8", "35", "3", "16", "16", "32", "4", "32", "32", "32", "5", "16", "16", "16", "6", "16", "16", "16", "7", "32", "32", "32", "8", "32", "32", "8", "9", "16", "16", "16", "10", "32", "16", "16", "11", "16", "16", "32", "12", "4", "4", "4", "13.6", "13", "2", "4", "4", "18.1" ], "cell_index": [ "CA(1,0)", "CA(1,1)", "CA(1,6)", "CA(1,7)", "CA(1,8)", "CA(1,9)", "CA(2,0)", "CA(2,6)", "CA(2,7)", "CA(2,8)", "CA(2,9)", "CA(3,0)", "CA(3,6)", "CA(3,7)", "CA(3,8)", "CA(4,0)", "CA(4,6)", "CA(4,7)", "CA(4,8)", "CA(5,0)", "CA(5,6)", "CA(5,7)", "CA(5,8)", "CA(6,0)", "CA(6,6)", "CA(6,7)", "CA(6,8)", "CA(7,0)", "CA(7,6)", "CA(7,7)", "CA(7,8)", "CA(8,0)", "CA(8,6)", "CA(8,7)", "CA(8,8)", "CA(9,0)", "CA(9,6)", "CA(9,7)", "CA(9,8)", "CA(10,0)", "CA(10,6)", "CA(10,7)", "CA(10,8)", "CA(11,0)", "CA(11,6)", "CA(11,7)", "CA(11,8)", "CA(12,0)", "CA(12,6)", "CA(12,7)", "CA(12,8)", "CA(12,9)", "CA(13,0)", "CA(13,6)", "CA(13,7)", "CA(13,8)", "CA(13,9)" ], "cell_row_idx": [ 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 2, 3, 3, 3, 3, 4, 4, 4, 4, 5, 5, 5, 5, 6, 6, 6, 6, 7, 7, 7, 7, 8, 8, 8, 8, 9, 9, 9, 9, 10, 10, 10, 10, 11, 11, 11, 11, 12, 12, 12, 12, 12, 13, 13, 13, 13, 13 ], "cell_col_idx": [ 0, 1, 6, 7, 8, 9, 0, 6, 7, 8, 9, 0, 6, 7, 8, 0, 6, 7, 8, 0, 6, 7, 8, 0, 6, 7, 8, 0, 6, 7, 8, 0, 6, 7, 8, 0, 6, 7, 8, 0, 6, 7, 8, 0, 6, 7, 8, 0, 6, 7, 8, 9, 0, 6, 7, 8, 9 ] }
{ "cell_index": [ "CA(1,0)", "CA(1,1)", "CA(1,6)", "CA(1,7)", "CA(1,8)", "CA(1,9)", "CA(2,0)", "CA(2,6)", "CA(2,7)", "CA(2,8)", "CA(2,9)", "CA(3,0)", "CA(3,6)", "CA(3,7)", "CA(3,8)", "CA(4,0)", "CA(4,6)", "CA(4,7)", "CA(4,8)", "CA(5,0)", "CA(5,6)", "CA(5,7)", "CA(5,8)", "CA(6,0)", "CA(6,6)", "CA(6,7)", "CA(6,8)", "CA(7,0)", "CA(7,6)", "CA(7,7)", "CA(7,8)", "CA(8,0)", "CA(8,6)", "CA(8,7)", "CA(8,8)", "CA(9,0)", "CA(9,6)", "CA(9,7)", "CA(9,8)", "CA(10,0)", "CA(10,6)", "CA(10,7)", "CA(10,8)", "CA(11,0)", "CA(11,6)", "CA(11,7)", "CA(11,8)", "CA(12,0)", "CA(12,6)", "CA(12,7)", "CA(12,8)", "CA(12,9)", "CA(13,0)", "CA(13,6)", "CA(13,7)", "CA(13,8)", "CA(13,9)" ], "cell_record": [ "{\"value\": \"1\", \"type\": \"Other\"}", "{\"value\": \"1\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"17.1\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"1\", \"unit\": \"xx\"}", "{\"value\": \"2\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"35\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"6a\", \"unit\": \"xx\"}", "{\"value\": \"3\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"7\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"9\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"10\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"11\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"12\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"13.6\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"6k\", \"unit\": \"xx\"}", "{\"value\": \"13\", \"type\": \"Other\"}", "{\"value\": \"2\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"18.1\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"6l\", \"unit\": \"xx\"}" ] }
PMC4018117
tbl3
<table-wrap><label>Table 3</label><caption><title>MRC and GI50 Values for 1 Analogues with Modifications on the Side Chain</title></caption><graphic></graphic><table><colgroup><col/><col/><col/><col/><col/><col/><col/><col/></colgroup><thead> <tr> <th>entry</th> <th>compd</th> <th>R1</th> <th>R2</th> <th>amox/clava,b</th> <th>cefazolina,b</th> <th>meropenema,c</th> <th>GI50d</th> </tr></thead><tbody> <tr> <td>1</td> <td>1</td> <td>H</td> <td>SO2PhpCl</td> <td>4</td> <td>4</td> <td>4</td> <td>17.1</td> </tr> <tr> <td>2</td> <td>11a</td> <td>H</td> <td>H</td> <td>32</td> <td>32</td> <td>32</td> <td>–</td> </tr> <tr> <td>3</td> <td>11b</td> <td>F</td> <td>H</td> <td>>32</td> <td>32</td> <td>16</td> <td>16.2</td> </tr> <tr> <td>4</td> <td>12a</td> <td>H</td> <td>TFA</td> <td>>32</td> <td>>32</td> <td>32</td> <td>–</td> </tr> <tr> <td>5</td> <td>12b</td> <td>H</td> <td>COBu</td> <td>>32</td> <td>>32</td> <td>32</td> <td>–</td> </tr> <tr> <td>6</td> <td>12c</td> <td>H</td> <td>COPhpCl</td> <td>>32</td> <td>>32</td> <td>>32</td> <td>–</td> </tr> <tr> <td>7</td> <td>12d</td> <td>H</td> <td>SO2Ph</td> <td>8</td> <td>8</td> <td>16</td> <td>–</td> </tr> <tr> <td>8</td> <td>12e</td> <td>H</td> <td>SO2PhpMe</td> <td>>32</td> <td>>32</td> <td>>32</td> <td>–</td> </tr> <tr> <td>9</td> <td>12f</td> <td>H</td> <td>SO2PhpF</td> <td>>32</td> <td>>32</td> <td>>32</td> <td>–</td> </tr> <tr> <td>10</td> <td>12g</td> <td>H</td> <td>SO2PhpBr</td> <td>4</td> <td>4</td> <td>8</td> <td>40</td> </tr> <tr> <td>11</td> <td>12h</td> <td>H</td> <td>SO2PhpI</td> <td>4</td> <td>4</td> <td>32</td> <td>33</td> </tr> <tr> <td>12</td> <td>12i</td> <td>H</td> <td>SO2Ph3,4Cl</td> <td>4</td> <td>2</td> <td>4</td> <td>12.8</td> </tr> <tr> <td>13</td> <td>12j</td> <td>H</td> <td>SO2Ph2,4Cl</td> <td>8</td> <td>>32</td> <td>4</td> <td>–</td> </tr> <tr> <td>14</td> <td>12k</td> <td>H</td> <td>SO2PhpCN</td> <td>16</td> <td>8</td> <td>16</td> <td>–</td> </tr> <tr> <td>15</td> <td>12l</td> <td>H</td> <td>SO2PhpNHAc</td> <td>>32</td> <td>>32</td> <td>32</td> <td>–</td> </tr> <tr> <td>16</td> <td>12m</td> <td>H</td> <td>SO25Py</td> <td>32</td> <td>32</td> <td>32</td> <td>–</td> </tr> <tr> <td>17</td> <td>12n</td> <td>H</td> <td>SO2PhpNO2</td> <td>>32</td> <td>>32</td> <td>>32</td> <td>–</td> </tr> <tr> <td>18</td> <td>12o</td> <td>H</td> <td>SO2PhpNH2</td> <td>16</td> <td>16</td> <td>16</td> <td>–</td> </tr> <tr> <td>20</td> <td>13a</td> <td>F</td> <td>SO2PhpOMe</td> <td>8</td> <td>4</td> <td>8</td> <td>49</td> </tr> <tr> <td>21</td> <td>13b</td> <td>F</td> <td>SO2PhpMe</td> <td>4</td> <td>4</td> <td>4</td> <td>22</td> </tr> <tr> <td>22</td> <td>13c</td> <td>F</td> <td>SO2PhpF</td> <td>4</td> <td>4</td> <td>4</td> <td>18.3</td> </tr> <tr> <td>23</td> <td>6l</td> <td>F</td> <td>SO2PhpCl</td> <td>2</td> <td>4</td> <td>4</td> <td>18.1</td> </tr> <tr> <td>24</td> <td>13d</td> <td>F</td> <td>SO2PhpBr</td> <td>1</td> <td>1</td> <td>1</td> <td>22</td> </tr> <tr> <td>25</td> <td>13e</td> <td>F</td> <td>SO2PhpI</td> <td>4</td> <td>2</td> <td>4</td> <td>19.6</td> </tr> <tr> <td>26</td> <td>13f</td> <td>F</td> <td>SO2Ph3,4Cl</td> <td>4</td> <td>4</td> <td>4</td> <td>31</td> </tr> <tr> <td>27</td> <td>13g</td> <td>F</td> <td>SO2PhpNHAc</td> <td>32</td> <td>32</td> <td>16</td> <td>32</td> </tr> <tr> <td>28</td> <td>13h</td> <td>F</td> <td>SO2PhpCN</td> <td>8</td> <td>4</td> <td>4</td> <td>17.0</td> </tr> <tr> <td>29</td> <td>13i</td> <td>F</td> <td>SO2PhpCF3</td> <td>4</td> <td>4</td> <td>4</td> <td>8.7</td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>MRC values are in μg/mL.</p></fn><fn><label>b</label><p>MRSA ATCC BAA-44.</p></fn><fn><label>c</label><p>MRSA ATCC 33592.</p></fn><fn><label>d</label><p>HeLa cells; GI50 values are in μg/mL.</p></fn></table-wrap-foot></table-wrap>
{ "cell_value": [ "1", "1", "4", "4", "4", "17.1", "2", "32", "32", "32", "3", "32", "32", "16", "16.2", "4", "32", "32", "32", "5", "32", "32", "32", "6", "32", "32", "32", "7", "8", "8", "16", "8", "32", "32", "32", "9", "32", "32", "32", "10", "4", "4", "8", "40", "11", "4", "4", "32", "33", "12", "4", "2", "4", "12.8", "13", "8", "32", "4", "14", "16", "8", "16", "15", "32", "32", "32", "16", "32", "32", "32", "17", "32", "32", "32", "18", "16", "16", "16", "20", "8", "4", "8", "49", "21", "4", "4", "4", "22", "22", "4", "4", "4", "18.3", "23", "2", "4", "4", "18.1", "24", "1", "1", "1", "22", "25", "4", "2", "4", "19.6", "26", "4", "4", "4", "31", "27", "32", "32", "16", "32", "28", "8", "4", "4", "17.0", "29", "4", "4", "4", "8.7" ], "cell_raw": [ "1", "1", "4", "4", "4", "17.1", "2", "32", "32", "32", "3", "32", "32", "16", "16.2", "4", "32", "32", "32", "5", "32", "32", "32", "6", "32", "32", "32", "7", "8", "8", "16", "8", "32", "32", "32", "9", "32", "32", "32", "10", "4", "4", "8", "40", "11", "4", "4", "32", "33", "12", "4", "2", "4", "12.8", "13", "8", "32", "4", "14", "16", "8", "16", "15", "32", "32", "32", "16", "32", "32", "32", "17", "32", "32", "32", "18", "16", "16", "16", "20", "8", "4", "8", "49", "21", "4", "4", "4", "22", "22", "4", "4", "4", "18.3", "23", "2", "4", "4", "18.1", "24", "1", "1", "1", "22", "25", "4", "2", "4", "19.6", "26", "4", "4", "4", "31", "27", "32", "32", "16", "32", "28", "8", "4", "4", "17.0", "29", "4", "4", "4", "8.7" ], "cell_index": [ "CA(1,0)", "CA(1,1)", "CA(1,4)", "CA(1,5)", "CA(1,6)", "CA(1,7)", "CA(2,0)", "CA(2,4)", "CA(2,5)", "CA(2,6)", "CA(3,0)", "CA(3,4)", "CA(3,5)", "CA(3,6)", "CA(3,7)", "CA(4,0)", "CA(4,4)", "CA(4,5)", "CA(4,6)", "CA(5,0)", "CA(5,4)", "CA(5,5)", "CA(5,6)", "CA(6,0)", "CA(6,4)", "CA(6,5)", "CA(6,6)", "CA(7,0)", "CA(7,4)", "CA(7,5)", "CA(7,6)", "CA(8,0)", "CA(8,4)", "CA(8,5)", "CA(8,6)", "CA(9,0)", "CA(9,4)", "CA(9,5)", "CA(9,6)", "CA(10,0)", "CA(10,4)", "CA(10,5)", "CA(10,6)", "CA(10,7)", "CA(11,0)", "CA(11,4)", "CA(11,5)", "CA(11,6)", "CA(11,7)", "CA(12,0)", "CA(12,4)", "CA(12,5)", "CA(12,6)", "CA(12,7)", "CA(13,0)", "CA(13,4)", "CA(13,5)", "CA(13,6)", "CA(14,0)", "CA(14,4)", "CA(14,5)", "CA(14,6)", "CA(15,0)", "CA(15,4)", "CA(15,5)", "CA(15,6)", "CA(16,0)", "CA(16,4)", "CA(16,5)", "CA(16,6)", "CA(17,0)", "CA(17,4)", "CA(17,5)", "CA(17,6)", "CA(18,0)", "CA(18,4)", "CA(18,5)", "CA(18,6)", "CA(19,0)", "CA(19,4)", "CA(19,5)", "CA(19,6)", "CA(19,7)", "CA(20,0)", "CA(20,4)", "CA(20,5)", "CA(20,6)", "CA(20,7)", "CA(21,0)", "CA(21,4)", "CA(21,5)", "CA(21,6)", "CA(21,7)", "CA(22,0)", "CA(22,4)", "CA(22,5)", "CA(22,6)", "CA(22,7)", "CA(23,0)", "CA(23,4)", "CA(23,5)", "CA(23,6)", "CA(23,7)", "CA(24,0)", "CA(24,4)", "CA(24,5)", "CA(24,6)", "CA(24,7)", "CA(25,0)", "CA(25,4)", "CA(25,5)", "CA(25,6)", "CA(25,7)", "CA(26,0)", "CA(26,4)", "CA(26,5)", "CA(26,6)", "CA(26,7)", "CA(27,0)", "CA(27,4)", "CA(27,5)", "CA(27,6)", "CA(27,7)", "CA(28,0)", "CA(28,4)", "CA(28,5)", "CA(28,6)", "CA(28,7)" ], "cell_row_idx": [ 1, 1, 1, 1, 1, 1, 2, 2, 2, 2, 3, 3, 3, 3, 3, 4, 4, 4, 4, 5, 5, 5, 5, 6, 6, 6, 6, 7, 7, 7, 7, 8, 8, 8, 8, 9, 9, 9, 9, 10, 10, 10, 10, 10, 11, 11, 11, 11, 11, 12, 12, 12, 12, 12, 13, 13, 13, 13, 14, 14, 14, 14, 15, 15, 15, 15, 16, 16, 16, 16, 17, 17, 17, 17, 18, 18, 18, 18, 19, 19, 19, 19, 19, 20, 20, 20, 20, 20, 21, 21, 21, 21, 21, 22, 22, 22, 22, 22, 23, 23, 23, 23, 23, 24, 24, 24, 24, 24, 25, 25, 25, 25, 25, 26, 26, 26, 26, 26, 27, 27, 27, 27, 27, 28, 28, 28, 28, 28 ], "cell_col_idx": [ 0, 1, 4, 5, 6, 7, 0, 4, 5, 6, 0, 4, 5, 6, 7, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7, 0, 4, 5, 6, 7 ] }
{ "cell_index": [ "CA(1,0)", "CA(1,1)", "CA(1,4)", "CA(1,5)", "CA(1,6)", "CA(1,7)", "CA(2,0)", "CA(2,4)", "CA(2,5)", "CA(2,6)", "CA(3,0)", "CA(3,4)", "CA(3,5)", "CA(3,6)", "CA(3,7)", "CA(4,0)", "CA(4,4)", "CA(4,5)", "CA(4,6)", "CA(5,0)", "CA(5,4)", "CA(5,5)", "CA(5,6)", "CA(6,0)", "CA(6,4)", "CA(6,5)", "CA(6,6)", "CA(7,0)", "CA(7,4)", "CA(7,5)", "CA(7,6)", "CA(8,0)", "CA(8,4)", "CA(8,5)", "CA(8,6)", "CA(9,0)", "CA(9,4)", "CA(9,5)", "CA(9,6)", "CA(10,0)", "CA(10,4)", "CA(10,5)", "CA(10,6)", "CA(10,7)", "CA(11,0)", "CA(11,4)", "CA(11,5)", "CA(11,6)", "CA(11,7)", "CA(12,0)", "CA(12,4)", "CA(12,5)", "CA(12,6)", "CA(12,7)", "CA(13,0)", "CA(13,4)", "CA(13,5)", "CA(13,6)", "CA(14,0)", "CA(14,4)", "CA(14,5)", "CA(14,6)", "CA(15,0)", "CA(15,4)", "CA(15,5)", "CA(15,6)", "CA(16,0)", "CA(16,4)", "CA(16,5)", "CA(16,6)", "CA(17,0)", "CA(17,4)", "CA(17,5)", "CA(17,6)", "CA(18,0)", "CA(18,4)", "CA(18,5)", "CA(18,6)", "CA(19,0)", "CA(19,4)", "CA(19,5)", "CA(19,6)", "CA(19,7)", "CA(20,0)", "CA(20,4)", "CA(20,5)", "CA(20,6)", "CA(20,7)", "CA(21,0)", "CA(21,4)", "CA(21,5)", "CA(21,6)", "CA(21,7)", "CA(22,0)", "CA(22,4)", "CA(22,5)", "CA(22,6)", "CA(22,7)", "CA(23,0)", "CA(23,4)", "CA(23,5)", "CA(23,6)", "CA(23,7)", "CA(24,0)", "CA(24,4)", "CA(24,5)", "CA(24,6)", "CA(24,7)", "CA(25,0)", "CA(25,4)", "CA(25,5)", "CA(25,6)", "CA(25,7)", "CA(26,0)", "CA(26,4)", "CA(26,5)", "CA(26,6)", "CA(26,7)", "CA(27,0)", "CA(27,4)", "CA(27,5)", "CA(27,6)", "CA(27,7)", "CA(28,0)", "CA(28,4)", "CA(28,5)", "CA(28,6)", "CA(28,7)" ], "cell_record": [ "{\"value\": \"1\", \"type\": \"Other\"}", "{\"value\": \"1\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"17.1\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"1\", \"unit\": \"xx\"}", "{\"value\": \"2\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"3\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16.2\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"11b\", \"unit\": \"xx\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"7\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"9\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"10\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"40\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"12g\", \"unit\": \"xx\"}", "{\"value\": \"11\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"33\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"12h\", \"unit\": \"xx\"}", "{\"value\": \"12\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"2\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"12.8\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"12i\", \"unit\": \"xx\"}", "{\"value\": \"13\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"14\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"15\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"17\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"18\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"20\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"49\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13a\", \"unit\": \"xx\"}", "{\"value\": \"21\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"22\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13b\", \"unit\": \"xx\"}", "{\"value\": \"22\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"18.3\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13c\", \"unit\": \"xx\"}", "{\"value\": \"23\", \"type\": \"Other\"}", "{\"value\": \"2\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"18.1\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"6l\", \"unit\": \"xx\"}", "{\"value\": \"24\", \"type\": \"Other\"}", "{\"value\": \"1\", \"type\": \"Other\"}", "{\"value\": \"1\", \"type\": \"Other\"}", "{\"value\": \"1\", \"type\": \"Other\"}", "{\"value\": \"22\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13d\", \"unit\": \"xx\"}", "{\"value\": \"25\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"2\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"19.6\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13e\", \"unit\": \"xx\"}", "{\"value\": \"26\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"31\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13f\", \"unit\": \"xx\"}", "{\"value\": \"27\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"Other\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"32\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13g\", \"unit\": \"xx\"}", "{\"value\": \"28\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"17.0\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13h\", \"unit\": \"xx\"}", "{\"value\": \"29\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"8.7\", \"type\": \"GI50\", \"target\": \"xx\", \"treatment\": \"13i\", \"unit\": \"xx\"}" ] }
PMC4106271
tbl3
<table-wrap><label>Table 3</label><caption><title>Efficiency and Potency of Further Characterized Piperine Derivatives and Piperinea</title></caption><table><colgroup><col/><col/><col/><col/><col/></colgroup><thead> <tr> <th>compd</th> <th>IGABA-max (%)</th> <th>EC50 (μM)</th> <th>nH</th> <th>n</th> </tr></thead><tbody> <tr> <td>piperine</td> <td>302 ± 27</td> <td>52.4 ± 9.3</td> <td>1.5 ± 0.2</td> <td>3</td> </tr> <tr> <td>22</td> <td>1581 ± 74**</td> <td>86.7 ± 13.9</td> <td>2.3 ± 0.2</td> <td>6</td> </tr> <tr> <td>23</td> <td>1673 ± 146**</td> <td>51.7 ± 9.5</td> <td>3.1 ± 0.8</td> <td>6</td> </tr> <tr> <td>25</td> <td>760 ± 47**</td> <td>13.8 ± 1.8**</td> <td>1.8 ± 0.1</td> <td>6</td> </tr> <tr> <td>35</td> <td>733 ± 60**</td> <td>67.7 ± 11.0</td> <td>1.9 ± 0.3</td> <td>6</td> </tr> <tr> <td>43</td> <td>505 ± 24**</td> <td>23.1 ± 3.3*</td> <td>1.6 ± 0.2</td> <td>6</td> </tr> <tr> <td>47</td> <td>603 ± 87*</td> <td>70.8 ± 21.1</td> <td>1.2 ± 0.2</td> <td>3</td> </tr> <tr> <td>53</td> <td>388 ± 64</td> <td>55.3 ± 17.6</td> <td>1.5 ± 0.2</td> <td>3</td> </tr> <tr> <td>56</td> <td>165 ± 4**</td> <td>36.8 ± 2.0</td> <td>1.2 ± 0.0</td> <td>3</td> </tr> <tr> <td>72</td> <td>706 ± 58**</td> <td>102.0 ± 11.2</td> <td>1.9 ± 0.2</td> <td>5</td> </tr> <tr> <td>73</td> <td>480 ± 85</td> <td>31.8 ± 5.3</td> <td>2.7 ± 0.2</td> <td>6</td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>From ref (31), including number of experiments n. Asterisks indicate significant differences from piperine: *p < 0.05; **p < 0.01.</p></fn></table-wrap-foot></table-wrap>
{ "cell_value": [ "302", "52.4", "1.5", "3", "22", "1581", "86.7", "2.3", "6", "23", "1673", "51.7", "3.1", "6", "25", "760", "13.8", "1.8", "6", "35", "733", "67.7", "1.9", "6", "43", "505", "23.1", "1.6", "6", "47", "603", "70.8", "1.2", "3", "53", "388", "55.3", "1.5", "3", "56", "165", "36.8", "1.2", "3", "72", "706", "102.0", "1.9", "5", "73", "480", "31.8", "2.7", "6" ], "cell_raw": [ "302 ± 27", "52.4 ± 9.3", "1.5 ± 0.2", "3", "22", "1581 ± 74**", "86.7 ± 13.9", "2.3 ± 0.2", "6", "23", "1673 ± 146**", "51.7 ± 9.5", "3.1 ± 0.8", "6", "25", "760 ± 47**", "13.8 ± 1.8**", "1.8 ± 0.1", "6", "35", "733 ± 60**", "67.7 ± 11.0", "1.9 ± 0.3", "6", "43", "505 ± 24**", "23.1 ± 3.3*", "1.6 ± 0.2", "6", "47", "603 ± 87*", "70.8 ± 21.1", "1.2 ± 0.2", "3", "53", "388 ± 64", "55.3 ± 17.6", "1.5 ± 0.2", "3", "56", "165 ± 4**", "36.8 ± 2.0", "1.2 ± 0.0", "3", "72", "706 ± 58**", "102.0 ± 11.2", "1.9 ± 0.2", "5", "73", "480 ± 85", "31.8 ± 5.3", "2.7 ± 0.2", "6" ], "cell_index": [ "CA(1,1)", "CA(1,2)", "CA(1,3)", "CA(1,4)", "CA(2,0)", "CA(2,1)", "CA(2,2)", "CA(2,3)", "CA(2,4)", "CA(3,0)", "CA(3,1)", "CA(3,2)", "CA(3,3)", "CA(3,4)", "CA(4,0)", "CA(4,1)", "CA(4,2)", "CA(4,3)", "CA(4,4)", "CA(5,0)", "CA(5,1)", "CA(5,2)", "CA(5,3)", "CA(5,4)", "CA(6,0)", "CA(6,1)", "CA(6,2)", "CA(6,3)", "CA(6,4)", "CA(7,0)", "CA(7,1)", "CA(7,2)", "CA(7,3)", "CA(7,4)", "CA(8,0)", "CA(8,1)", "CA(8,2)", "CA(8,3)", "CA(8,4)", "CA(9,0)", "CA(9,1)", "CA(9,2)", "CA(9,3)", "CA(9,4)", "CA(10,0)", "CA(10,1)", "CA(10,2)", "CA(10,3)", "CA(10,4)", "CA(11,0)", "CA(11,1)", "CA(11,2)", "CA(11,3)", "CA(11,4)" ], "cell_row_idx": [ 1, 1, 1, 1, 2, 2, 2, 2, 2, 3, 3, 3, 3, 3, 4, 4, 4, 4, 4, 5, 5, 5, 5, 5, 6, 6, 6, 6, 6, 7, 7, 7, 7, 7, 8, 8, 8, 8, 8, 9, 9, 9, 9, 9, 10, 10, 10, 10, 10, 11, 11, 11, 11, 11 ], "cell_col_idx": [ 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4, 0, 1, 2, 3, 4 ] }
{ "cell_index": [ "CA(1,1)", "CA(1,2)", "CA(1,3)", "CA(1,4)", "CA(2,0)", "CA(2,1)", "CA(2,2)", "CA(2,3)", "CA(2,4)", "CA(3,0)", "CA(3,1)", "CA(3,2)", "CA(3,3)", "CA(3,4)", "CA(4,0)", "CA(4,1)", "CA(4,2)", "CA(4,3)", "CA(4,4)", "CA(5,0)", "CA(5,1)", "CA(5,2)", "CA(5,3)", "CA(5,4)", "CA(6,0)", "CA(6,1)", "CA(6,2)", "CA(6,3)", "CA(6,4)", "CA(7,0)", "CA(7,1)", "CA(7,2)", "CA(7,3)", "CA(7,4)", "CA(8,0)", "CA(8,1)", "CA(8,2)", "CA(8,3)", "CA(8,4)", "CA(9,0)", "CA(9,1)", "CA(9,2)", "CA(9,3)", "CA(9,4)", "CA(10,0)", "CA(10,1)", "CA(10,2)", "CA(10,3)", "CA(10,4)", "CA(11,0)", "CA(11,1)", "CA(11,2)", "CA(11,3)", "CA(11,4)" ], "cell_record": [ "{\"value\": \"302\", \"type\": \"Other\"}", "{\"value\": \"52.4\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"piperine\", \"unit\": \"μM\"}", "{\"value\": \"1.5\", \"type\": \"Other\"}", "{\"value\": \"3\", \"type\": \"Other\"}", "{\"value\": \"22\", \"type\": \"Other\"}", "{\"value\": \"1581\", \"type\": \"Other\"}", "{\"value\": \"86.7\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"22\", \"unit\": \"μM\"}", "{\"value\": \"2.3\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"23\", \"type\": \"Other\"}", "{\"value\": \"1673\", \"type\": \"Other\"}", "{\"value\": \"51.7\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"23\", \"unit\": \"μM\"}", "{\"value\": \"3.1\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"25\", \"type\": \"Other\"}", "{\"value\": \"760\", \"type\": \"Other\"}", "{\"value\": \"13.8\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"25\", \"unit\": \"μM\"}", "{\"value\": \"1.8\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"35\", \"type\": \"Other\"}", "{\"value\": \"733\", \"type\": \"Other\"}", "{\"value\": \"67.7\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"35\", \"unit\": \"μM\"}", "{\"value\": \"1.9\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"43\", \"type\": \"Other\"}", "{\"value\": \"505\", \"type\": \"Other\"}", "{\"value\": \"23.1\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"43\", \"unit\": \"μM\"}", "{\"value\": \"1.6\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"47\", \"type\": \"Other\"}", "{\"value\": \"603\", \"type\": \"Other\"}", "{\"value\": \"70.8\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"47\", \"unit\": \"μM\"}", "{\"value\": \"1.2\", \"type\": \"Other\"}", "{\"value\": \"3\", \"type\": \"Other\"}", "{\"value\": \"53\", \"type\": \"Other\"}", "{\"value\": \"388\", \"type\": \"Other\"}", "{\"value\": \"55.3\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"53\", \"unit\": \"μM\"}", "{\"value\": \"1.5\", \"type\": \"Other\"}", "{\"value\": \"3\", \"type\": \"Other\"}", "{\"value\": \"56\", \"type\": \"Other\"}", "{\"value\": \"165\", \"type\": \"Other\"}", "{\"value\": \"36.8\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"56\", \"unit\": \"μM\"}", "{\"value\": \"1.2\", \"type\": \"Other\"}", "{\"value\": \"3\", \"type\": \"Other\"}", "{\"value\": \"72\", \"type\": \"Other\"}", "{\"value\": \"706\", \"type\": \"Other\"}", "{\"value\": \"102.0\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"72\", \"unit\": \"μM\"}", "{\"value\": \"1.9\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}", "{\"value\": \"73\", \"type\": \"Other\"}", "{\"value\": \"480\", \"type\": \"Other\"}", "{\"value\": \"31.8\", \"type\": \"EC50\", \"target\": \"xx\", \"treatment\": \"73\", \"unit\": \"μM\"}", "{\"value\": \"2.7\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}" ] }
PMC4106271
tbl4
<table-wrap><label>Table 4</label><caption><title>Efficiency and Potency of 23 and 25 on GABAA Receptors of Different Subunit Compositionsa</title></caption><table><colgroup><col/><col/><col/><col/><col/></colgroup><thead> <tr> <th>receptor subtype</th> <th>IGABA,max (%)</th> <th>EC50 (μM)</th> <th>nH</th> <th>n</th> </tr></thead><tbody> <tr> <td colspan="5">Compound 23</td> </tr> <tr> <td>α1β1γ2S</td> <td>1157 ± 69*</td> <td>57.5 ± 7.3</td> <td>1.8 ± 0.1</td> <td>5</td> </tr> <tr> <td>α1β2γ2S</td> <td>1673 ± 146</td> <td>51.7 ± 9.5</td> <td>3.1 ± 0.8</td> <td>6</td> </tr> <tr> <td>α1β3γ2S</td> <td>1240 ± 128</td> <td>34.7 ± 5.7</td> <td>1.9 ± 0.2</td> <td>5</td> </tr> <tr> <td>α2β2γ2S</td> <td>980 ± 129**</td> <td>26.4 ± 6.6</td> <td>1.9 ± 0.4</td> <td>6</td> </tr> <tr> <td>α3β2γ2S</td> <td>1285 ± 142</td> <td>36.6 ± 7.2</td> <td>1.9 ± 0.3</td> <td>5</td> </tr> <tr> <td>α4β2γ2S</td> <td>1316 ± 55*</td> <td>34.7 ± 3.8</td> <td>1.7 ± 0.1</td> <td>7</td> </tr> <tr> <td>α5β2γ2S</td> <td>1624 ± 156</td> <td>61.9 ± 10.4</td> <td>1.4 ± 0.1</td> <td>7</td> </tr> <tr> <td colspan="5">Compound 25</td> </tr> <tr> <td>α1β1γ2S</td> <td>152 ± 30**</td> <td>15.9 ± 4.9</td> <td>1.3 ± 0.6</td> <td>5</td> </tr> <tr> <td>α1β2γ2S</td> <td>760 ± 47</td> <td>13.8 ± 1.8</td> <td>1.8 ± 0.1</td> <td>8</td> </tr> <tr> <td>α1β3γ2S</td> <td>587 ± 8**</td> <td>29.5 ± 2.9**</td> <td>1.5 ± 0.1</td> <td>4</td> </tr> <tr> <td>α2β2γ2S</td> <td>512 ± 26**</td> <td>14.8 ± 1.9</td> <td>2.2 ± 0.3</td> <td>4</td> </tr> <tr> <td>α3β2γ2S</td> <td>617 ± 42*</td> <td>16.0 ± 2.7</td> <td>1.8 ± 0.1</td> <td>6</td> </tr> <tr> <td>α4β2γ2S</td> <td>419 ± 73**</td> <td>56.7 ± 21.0</td> <td>1.3 ± 0.3</td> <td>4</td> </tr> <tr> <td>α5β2γ2S</td> <td>387 ± 20**</td> <td>17.2 ± 1.4</td> <td>1.7 ± 0.2</td> <td>5</td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>Asterisks indicate significant differences from α1β2γ2S receptor subtype as follows: *p < 0.05; **p < 0.01.</p></fn></table-wrap-foot></table-wrap>
{ "cell_value": [ "1157", "57.5", "1.8", "5", "1673", "51.7", "3.1", "6", "1240", "34.7", "1.9", "5", "980", "26.4", "1.9", "6", "1285", "36.6", "1.9", "5", "1316", "34.7", "1.7", "7", "1624", "61.9", "1.4", "7", "152", "15.9", "1.3", "5", "760", "13.8", "1.8", "8", "587", "29.5", "1.5", "4", "512", "14.8", "2.2", "4", "617", "16.0", "1.8", "6", "419", "56.7", "1.3", "4", "387", "17.2", "1.7", "5" ], "cell_raw": [ "1157 ± 69*", "57.5 ± 7.3", "1.8 ± 0.1", "5", "1673 ± 146", "51.7 ± 9.5", "3.1 ± 0.8", "6", "1240 ± 128", "34.7 ± 5.7", "1.9 ± 0.2", "5", "980 ± 129**", "26.4 ± 6.6", "1.9 ± 0.4", "6", "1285 ± 142", "36.6 ± 7.2", "1.9 ± 0.3", "5", "1316 ± 55*", "34.7 ± 3.8", "1.7 ± 0.1", "7", "1624 ± 156", "61.9 ± 10.4", "1.4 ± 0.1", "7", "152 ± 30**", "15.9 ± 4.9", "1.3 ± 0.6", "5", "760 ± 47", "13.8 ± 1.8", "1.8 ± 0.1", "8", "587 ± 8**", "29.5 ± 2.9**", "1.5 ± 0.1", "4", "512 ± 26**", "14.8 ± 1.9", "2.2 ± 0.3", "4", "617 ± 42*", "16.0 ± 2.7", "1.8 ± 0.1", "6", "419 ± 73**", "56.7 ± 21.0", "1.3 ± 0.3", "4", "387 ± 20**", "17.2 ± 1.4", "1.7 ± 0.2", "5" ], "cell_index": [ "CA(2,1)", "CA(2,2)", "CA(2,3)", "CA(2,4)", "CA(3,1)", "CA(3,2)", "CA(3,3)", "CA(3,4)", "CA(4,1)", "CA(4,2)", "CA(4,3)", "CA(4,4)", "CA(5,1)", "CA(5,2)", "CA(5,3)", "CA(5,4)", "CA(6,1)", "CA(6,2)", "CA(6,3)", "CA(6,4)", "CA(7,1)", "CA(7,2)", "CA(7,3)", "CA(7,4)", "CA(8,1)", "CA(8,2)", "CA(8,3)", "CA(8,4)", "CA(10,1)", "CA(10,2)", "CA(10,3)", "CA(10,4)", "CA(11,1)", "CA(11,2)", "CA(11,3)", "CA(11,4)", "CA(12,1)", "CA(12,2)", "CA(12,3)", "CA(12,4)", "CA(13,1)", "CA(13,2)", "CA(13,3)", "CA(13,4)", "CA(14,1)", "CA(14,2)", "CA(14,3)", "CA(14,4)", "CA(15,1)", "CA(15,2)", "CA(15,3)", "CA(15,4)", "CA(16,1)", "CA(16,2)", "CA(16,3)", "CA(16,4)" ], "cell_row_idx": [ 2, 2, 2, 2, 3, 3, 3, 3, 4, 4, 4, 4, 5, 5, 5, 5, 6, 6, 6, 6, 7, 7, 7, 7, 8, 8, 8, 8, 10, 10, 10, 10, 11, 11, 11, 11, 12, 12, 12, 12, 13, 13, 13, 13, 14, 14, 14, 14, 15, 15, 15, 15, 16, 16, 16, 16 ], "cell_col_idx": [ 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4, 1, 2, 3, 4 ] }
{ "cell_index": [ "CA(2,1)", "CA(2,2)", "CA(2,3)", "CA(2,4)", "CA(3,1)", "CA(3,2)", "CA(3,3)", "CA(3,4)", "CA(4,1)", "CA(4,2)", "CA(4,3)", "CA(4,4)", "CA(5,1)", "CA(5,2)", "CA(5,3)", "CA(5,4)", "CA(6,1)", "CA(6,2)", "CA(6,3)", "CA(6,4)", "CA(7,1)", "CA(7,2)", "CA(7,3)", "CA(7,4)", "CA(8,1)", "CA(8,2)", "CA(8,3)", "CA(8,4)", "CA(10,1)", "CA(10,2)", "CA(10,3)", "CA(10,4)", "CA(11,1)", "CA(11,2)", "CA(11,3)", "CA(11,4)", "CA(12,1)", "CA(12,2)", "CA(12,3)", "CA(12,4)", "CA(13,1)", "CA(13,2)", "CA(13,3)", "CA(13,4)", "CA(14,1)", "CA(14,2)", "CA(14,3)", "CA(14,4)", "CA(15,1)", "CA(15,2)", "CA(15,3)", "CA(15,4)", "CA(16,1)", "CA(16,2)", "CA(16,3)", "CA(16,4)" ], "cell_record": [ "{\"value\": \"1157\", \"type\": \"Other\"}", "{\"value\": \"57.5\", \"type\": \"EC50\", \"target\": \"α1β1γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}", "{\"value\": \"1.8\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}", "{\"value\": \"1673\", \"type\": \"Other\"}", "{\"value\": \"51.7\", \"type\": \"EC50\", \"target\": \"α1β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}", "{\"value\": \"3.1\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"1240\", \"type\": \"Other\"}", "{\"value\": \"34.7\", \"type\": \"EC50\", \"target\": \"α1β3γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}", "{\"value\": \"1.9\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}", "{\"value\": \"980\", \"type\": \"Other\"}", "{\"value\": \"26.4\", \"type\": \"EC50\", \"target\": \"α2β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}", "{\"value\": \"1.9\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"1285\", \"type\": \"Other\"}", "{\"value\": \"36.6\", \"type\": \"EC50\", \"target\": \"α3β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}", "{\"value\": \"1.9\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}", "{\"value\": \"1316\", \"type\": \"Other\"}", "{\"value\": \"34.7\", \"type\": \"EC50\", \"target\": \"α4β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}", "{\"value\": \"1.7\", \"type\": \"Other\"}", "{\"value\": \"7\", \"type\": \"Other\"}", "{\"value\": \"1624\", \"type\": \"Other\"}", "{\"value\": \"61.9\", \"type\": \"EC50\", \"target\": \"α5β2γ2S\", \"treatment\": \"Compound 23\", \"unit\": \"μM\"}", "{\"value\": \"1.4\", \"type\": \"Other\"}", "{\"value\": \"7\", \"type\": \"Other\"}", "{\"value\": \"152\", \"type\": \"Other\"}", "{\"value\": \"15.9\", \"type\": \"EC50\", \"target\": \"α1β1γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}", "{\"value\": \"1.3\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}", "{\"value\": \"760\", \"type\": \"Other\"}", "{\"value\": \"13.8\", \"type\": \"EC50\", \"target\": \"α1β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}", "{\"value\": \"1.8\", \"type\": \"Other\"}", "{\"value\": \"8\", \"type\": \"Other\"}", "{\"value\": \"587\", \"type\": \"Other\"}", "{\"value\": \"29.5\", \"type\": \"EC50\", \"target\": \"α1β3γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}", "{\"value\": \"1.5\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"512\", \"type\": \"Other\"}", "{\"value\": \"14.8\", \"type\": \"EC50\", \"target\": \"α2β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}", "{\"value\": \"2.2\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"617\", \"type\": \"Other\"}", "{\"value\": \"16.0\", \"type\": \"EC50\", \"target\": \"α3β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}", "{\"value\": \"1.8\", \"type\": \"Other\"}", "{\"value\": \"6\", \"type\": \"Other\"}", "{\"value\": \"419\", \"type\": \"Other\"}", "{\"value\": \"56.7\", \"type\": \"EC50\", \"target\": \"α4β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}", "{\"value\": \"1.3\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"387\", \"type\": \"Other\"}", "{\"value\": \"17.2\", \"type\": \"EC50\", \"target\": \"α5β2γ2S\", \"treatment\": \"Compound 25\", \"unit\": \"μM\"}", "{\"value\": \"1.7\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}" ] }
PMC4203399
tbl1
<table-wrap><label>Table 1</label><caption><title>Biological Activities of the Target Pyrazolobenzothiazines 2a–u, 3, 4, and 5</title></caption><graphic></graphic><table><colgroup><col/><col/><col/><col/><col/><col/><col/></colgroup><thead> <tr> <th> </th> <th> </th> <th> </th> <th colspan="4">cell-based replicon assay<hr/></th> </tr> <tr> <th>compd</th> <th>R</th> <th>anti-NS5B assay, IC50 a (μM)</th> <th>EC50 b (μM)</th> <th>EC90 c (μM)</th> <th>CC50 d (μM)</th> <th>SI e</th> </tr></thead><tbody> <tr> <td>2a</td> <td>(3-Cl)Ph</td> <td>4.3 ± 0.2</td> <td>9.8 ± 3.2</td> <td>41 ± 11</td> <td>>179</td> <td>>18</td> </tr> <tr> <td>2b</td> <td>(4-Cl)Ph</td> <td>7.9 ± 0.3</td> <td>8.1 ± 4.3</td> <td>23.3 ± 11.4</td> <td>>224</td> <td>>28</td> </tr> <tr> <td>2c</td> <td>(2-Cl)Ph</td> <td>17.8 ± 0.5</td> <td>7.4 ± 2.1</td> <td>20.8 ± 3.9</td> <td>>224</td> <td>>30</td> </tr> <tr> <td>2d</td> <td>(3-Br)Ph</td> <td>7.7 ± 0.2</td> <td>8.3 ± 0.5</td> <td>26 ± 5</td> <td>>166</td> <td>>20</td> </tr> <tr> <td>2e</td> <td>(4-Br)Ph</td> <td>12.1 ± 0.5</td> <td>7.4 ± 0.8</td> <td>21 ± 5</td> <td>>166</td> <td>>22</td> </tr> <tr> <td>2f</td> <td>(2-Br)Ph</td> <td>26.5 ± 3.3</td> <td>12.0 ± 0.4</td> <td>NDg</td> <td>107 ± 34</td> <td>8.9</td> </tr> <tr> <td>2g</td> <td>(3-Me)Ph</td> <td>21.2 ± 4.5</td> <td>5.1 ± 0.6</td> <td>11.8 ± 1.2</td> <td>>233</td> <td>>46</td> </tr> <tr> <td>2h</td> <td>(4-Me)Ph</td> <td>14.7 ± 0.2</td> <td>4.8 ± 1.7</td> <td>19.6 ± 11.8</td> <td>>186</td> <td>39</td> </tr> <tr> <td>2i</td> <td>(2-Me)Ph</td> <td>30.8 ± 3.8</td> <td>14.3 ± 1.1</td> <td>NDg</td> <td>>233</td> <td>>16</td> </tr> <tr> <td>2j</td> <td>(3-OMe)Ph</td> <td>NAf</td> <td>11 ± 2</td> <td>NDg</td> <td>>181</td> <td>>16</td> </tr> <tr> <td>2k</td> <td>(4-OMe)Ph</td> <td>NAf</td> <td>8.1 ± 1.5</td> <td>25.0 ± 7.3</td> <td>>226</td> <td>>28</td> </tr> <tr> <td>2l</td> <td>(3-CF3)Ph</td> <td>23.7 ± 0.9</td> <td>7.7 ± 1.9</td> <td>33.2 ± 24.9</td> <td>>211</td> <td>>28</td> </tr> <tr> <td>2m</td> <td>(4-CF3)Ph</td> <td>36.3 ± 4.2</td> <td>7.3 ± 0.8</td> <td>31.2</td> <td>>169</td> <td>>23</td> </tr> <tr> <td>2n</td> <td>(2-CF3)Ph</td> <td>NAf</td> <td>25.0 ± 3</td> <td>NDg</td> <td>>169</td> <td>>7</td> </tr> <tr> <td>2o</td> <td>(3,4-diF)Ph</td> <td>25.4 ± 3.8</td> <td>13.9 ± 0.4</td> <td>NDg</td> <td>138 ± 24</td> <td>9.9</td> </tr> <tr> <td>2p</td> <td>(3,4-diCl)Ph</td> <td>2.7 ± 0.3</td> <td>9.7 ± 1.8</td> <td>NDg</td> <td>>168</td> <td>>17</td> </tr> <tr> <td>2q</td> <td>(3,4-diMe)Ph</td> <td>NAf</td> <td>6.2 ± 0.3</td> <td>20 ± 2</td> <td>>181</td> <td>>29</td> </tr> <tr> <td>2r</td> <td>(3-Cl,4-Me)Ph</td> <td>8.0 ± 1.0</td> <td>7.0 ± 2.0</td> <td>37 ± 4</td> <td>>175</td> <td>>25</td> </tr> <tr> <td>2s</td> <td>(3-CF3,4-Cl)Ph</td> <td>NAf</td> <td>6.4 ± 1.7</td> <td>NDg</td> <td>>160</td> <td>>25</td> </tr> <tr> <td>2t</td> <td>Cy</td> <td>43.0 ± 0.7</td> <td>4.5 ± 0.6</td> <td>11 ± 2</td> <td>44 ± 38</td> <td>9.7</td> </tr> <tr> <td>2u</td> <td>H</td> <td>NAf</td> <td>88.2 ± 42.8</td> <td>65.2</td> <td>155 ± 50.5</td> <td>2.5</td> </tr> <tr> <td>3</td> <td> </td> <td>NAf</td> <td>4.5 ± 0.6</td> <td>NDg</td> <td>56</td> <td>12</td> </tr> <tr> <td>4</td> <td> </td> <td>NAf</td> <td>15 ± 2</td> <td>34 ± 7</td> <td>>192</td> <td>>13</td> </tr> <tr> <td>5</td> <td> </td> <td>NAf</td> <td>80.8 ± 9.4</td> <td>NDg</td> <td>160 ± 18.2</td> <td>2.3</td> </tr> <tr> <td>1h</td> <td>(3-F)Ph</td> <td>21.0 ± 2.8</td> <td>7.5 ± 2.5</td> <td>42.0 ± 2.0</td> <td>>370</td> <td>>49</td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>IC50 = concentration of compound that inhibits 50% enzyme activity in vitro. The reported values represent the mean ± SD of data derived from two independent experiments performed in duplicate.</p></fn><fn><label>b</label><p>EC50 = the effective concentration that is required to inhibit virus replication by 50% as quantified by luciferase reporter signal. The reported values represent the mean ± SD of data derived from at least three dose–response curves.</p></fn><fn><label>c</label><p>EC90 = the effective concentration that is required to inhibit virus replication by 90% as quantified by luciferase reporter signal. The reported values represent the mean ± SD of data derived from at least three independent dose–response curves.</p></fn><fn><label>d</label><p>CC50 = concentration that is required to reduce the bioreduction of MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) into formazan by 50% and is representative of the antimetabolic effect of the compound on the host cell. The reported value represents the mean ± SD of data derived from at least three dose–response curves.</p></fn><fn><label>e</label><p>SI = selectivity index (ratio of CC50 to EC50).</p></fn><fn><label>f</label><p>NA = not active. These compounds were not able to reach ≥50% inhibition of NS5B RdRp activity at 50 μM.</p></fn><fn><label>g</label><p>ND = not determined. These compounds were not able to reach 90% inhibition of HCV replication at any concentration employed.</p></fn><fn><label>h</label><p>Data from ref (17).</p></fn></table-wrap-foot></table-wrap>
{ "cell_value": [ "4.3", "9.8", "41", "179", "18", "7.9", "8.1", "23.3", "224", "28", "17.8", "7.4", "20.8", "224", "30", "7.7", "8.3", "26", "166", "20", "12.1", "7.4", "21", "166", "22", "26.5", "12.0", "107", "8.9", "21.2", "5.1", "11.8", "233", "46", "14.7", "4.8", "19.6", "186", "39", "30.8", "14.3", "233", "16", "11", "181", "16", "8.1", "25.0", "226", "28", "23.7", "7.7", "33.2", "211", "28", "36.3", "7.3", "31.2", "169", "23", "25.0", "169", "7", "25.4", "13.9", "138", "9.9", "2.7", "9.7", "168", "17", "6.2", "20", "181", "29", "8.0", "7.0", "37", "175", "25", "6.4", "160", "25", "43.0", "4.5", "11", "44", "9.7", "88.2", "65.2", "155", "2.5", "3", "4.5", "56", "12", "4", "15", "34", "192", "13", "5", "80.8", "160", "2.3", "21.0", "7.5", "42.0", "370", "49" ], "cell_raw": [ "4.3 ± 0.2", "9.8 ± 3.2", "41 ± 11", "179", "18", "7.9 ± 0.3", "8.1 ± 4.3", "23.3 ± 11.4", "224", "28", "17.8 ± 0.5", "7.4 ± 2.1", "20.8 ± 3.9", "224", "30", "7.7 ± 0.2", "8.3 ± 0.5", "26 ± 5", "166", "20", "12.1 ± 0.5", "7.4 ± 0.8", "21 ± 5", "166", "22", "26.5 ± 3.3", "12.0 ± 0.4", "107 ± 34", "8.9", "21.2 ± 4.5", "5.1 ± 0.6", "11.8 ± 1.2", "233", "46", "14.7 ± 0.2", "4.8 ± 1.7", "19.6 ± 11.8", "186", "39", "30.8 ± 3.8", "14.3 ± 1.1", "233", "16", "11 ± 2", "181", "16", "8.1 ± 1.5", "25.0 ± 7.3", "226", "28", "23.7 ± 0.9", "7.7 ± 1.9", "33.2 ± 24.9", "211", "28", "36.3 ± 4.2", "7.3 ± 0.8", "31.2", "169", "23", "25.0 ± 3", "169", "7", "25.4 ± 3.8", "13.9 ± 0.4", "138 ± 24", "9.9", "2.7 ± 0.3", "9.7 ± 1.8", "168", "17", "6.2 ± 0.3", "20 ± 2", "181", "29", "8.0 ± 1.0", "7.0 ± 2.0", "37 ± 4", "175", "25", "6.4 ± 1.7", "160", "25", "43.0 ± 0.7", "4.5 ± 0.6", "11 ± 2", "44 ± 38", "9.7", "88.2 ± 42.8", "65.2", "155 ± 50.5", "2.5", "3", "4.5 ± 0.6", "56", "12", "4", "15 ± 2", "34 ± 7", "192", "13", "5", "80.8 ± 9.4", "160 ± 18.2", "2.3", "21.0 ± 2.8", "7.5 ± 2.5", "42.0 ± 2.0", "370", "49" ], "cell_index": [ "CA(2,2)", "CA(2,3)", "CA(2,4)", "CA(2,5)", "CA(2,6)", "CA(3,2)", "CA(3,3)", "CA(3,4)", "CA(3,5)", "CA(3,6)", "CA(4,2)", "CA(4,3)", "CA(4,4)", "CA(4,5)", "CA(4,6)", "CA(5,2)", "CA(5,3)", "CA(5,4)", "CA(5,5)", "CA(5,6)", "CA(6,2)", "CA(6,3)", "CA(6,4)", "CA(6,5)", "CA(6,6)", "CA(7,2)", "CA(7,3)", "CA(7,5)", "CA(7,6)", "CA(8,2)", "CA(8,3)", "CA(8,4)", "CA(8,5)", "CA(8,6)", "CA(9,2)", "CA(9,3)", "CA(9,4)", "CA(9,5)", "CA(9,6)", "CA(10,2)", "CA(10,3)", "CA(10,5)", "CA(10,6)", "CA(11,3)", "CA(11,5)", "CA(11,6)", "CA(12,3)", "CA(12,4)", "CA(12,5)", "CA(12,6)", "CA(13,2)", "CA(13,3)", "CA(13,4)", "CA(13,5)", "CA(13,6)", "CA(14,2)", "CA(14,3)", "CA(14,4)", "CA(14,5)", "CA(14,6)", "CA(15,3)", "CA(15,5)", "CA(15,6)", "CA(16,2)", "CA(16,3)", "CA(16,5)", "CA(16,6)", "CA(17,2)", "CA(17,3)", "CA(17,5)", "CA(17,6)", "CA(18,3)", "CA(18,4)", "CA(18,5)", "CA(18,6)", "CA(19,2)", "CA(19,3)", "CA(19,4)", "CA(19,5)", "CA(19,6)", "CA(20,3)", "CA(20,5)", "CA(20,6)", "CA(21,2)", "CA(21,3)", "CA(21,4)", "CA(21,5)", "CA(21,6)", "CA(22,3)", "CA(22,4)", "CA(22,5)", "CA(22,6)", "CA(23,0)", "CA(23,3)", "CA(23,5)", "CA(23,6)", "CA(24,0)", "CA(24,3)", "CA(24,4)", "CA(24,5)", "CA(24,6)", "CA(25,0)", "CA(25,3)", "CA(25,5)", "CA(25,6)", "CA(26,2)", "CA(26,3)", "CA(26,4)", "CA(26,5)", "CA(26,6)" ], "cell_row_idx": [ 2, 2, 2, 2, 2, 3, 3, 3, 3, 3, 4, 4, 4, 4, 4, 5, 5, 5, 5, 5, 6, 6, 6, 6, 6, 7, 7, 7, 7, 8, 8, 8, 8, 8, 9, 9, 9, 9, 9, 10, 10, 10, 10, 11, 11, 11, 12, 12, 12, 12, 13, 13, 13, 13, 13, 14, 14, 14, 14, 14, 15, 15, 15, 16, 16, 16, 16, 17, 17, 17, 17, 18, 18, 18, 18, 19, 19, 19, 19, 19, 20, 20, 20, 21, 21, 21, 21, 21, 22, 22, 22, 22, 23, 23, 23, 23, 24, 24, 24, 24, 24, 25, 25, 25, 25, 26, 26, 26, 26, 26 ], "cell_col_idx": [ 2, 3, 4, 5, 6, 2, 3, 4, 5, 6, 2, 3, 4, 5, 6, 2, 3, 4, 5, 6, 2, 3, 4, 5, 6, 2, 3, 5, 6, 2, 3, 4, 5, 6, 2, 3, 4, 5, 6, 2, 3, 5, 6, 3, 5, 6, 3, 4, 5, 6, 2, 3, 4, 5, 6, 2, 3, 4, 5, 6, 3, 5, 6, 2, 3, 5, 6, 2, 3, 5, 6, 3, 4, 5, 6, 2, 3, 4, 5, 6, 3, 5, 6, 2, 3, 4, 5, 6, 3, 4, 5, 6, 0, 3, 5, 6, 0, 3, 4, 5, 6, 0, 3, 5, 6, 2, 3, 4, 5, 6 ] }
{ "cell_index": [ "CA(2,2)", "CA(2,3)", "CA(2,4)", "CA(2,5)", "CA(2,6)", "CA(3,2)", "CA(3,3)", "CA(3,4)", "CA(3,5)", "CA(3,6)", "CA(4,2)", "CA(4,3)", "CA(4,4)", "CA(4,5)", "CA(4,6)", "CA(5,2)", "CA(5,3)", "CA(5,4)", "CA(5,5)", "CA(5,6)", "CA(6,2)", "CA(6,3)", "CA(6,4)", "CA(6,5)", "CA(6,6)", "CA(7,2)", "CA(7,3)", "CA(7,5)", "CA(7,6)", "CA(8,2)", "CA(8,3)", "CA(8,4)", "CA(8,5)", "CA(8,6)", "CA(9,2)", "CA(9,3)", "CA(9,4)", "CA(9,5)", "CA(9,6)", "CA(10,2)", "CA(10,3)", "CA(10,5)", "CA(10,6)", "CA(11,3)", "CA(11,5)", "CA(11,6)", "CA(12,3)", "CA(12,4)", "CA(12,5)", "CA(12,6)", "CA(13,2)", "CA(13,3)", "CA(13,4)", "CA(13,5)", "CA(13,6)", "CA(14,2)", "CA(14,3)", "CA(14,4)", "CA(14,5)", "CA(14,6)", "CA(15,3)", "CA(15,5)", "CA(15,6)", "CA(16,2)", "CA(16,3)", "CA(16,5)", "CA(16,6)", "CA(17,2)", "CA(17,3)", "CA(17,5)", "CA(17,6)", "CA(18,3)", "CA(18,4)", "CA(18,5)", "CA(18,6)", "CA(19,2)", "CA(19,3)", "CA(19,4)", "CA(19,5)", "CA(19,6)", "CA(20,3)", "CA(20,5)", "CA(20,6)", "CA(21,2)", "CA(21,3)", "CA(21,4)", "CA(21,5)", "CA(21,6)", "CA(22,3)", "CA(22,4)", "CA(22,5)", "CA(22,6)", "CA(23,0)", "CA(23,3)", "CA(23,5)", "CA(23,6)", "CA(24,0)", "CA(24,3)", "CA(24,4)", "CA(24,5)", "CA(24,6)", "CA(25,0)", "CA(25,3)", "CA(25,5)", "CA(25,6)", "CA(26,2)", "CA(26,3)", "CA(26,4)", "CA(26,5)", "CA(26,6)" ], "cell_record": [ "{\"value\": \"4.3\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2a\", \"unit\": \"μM\"}", "{\"value\": \"9.8\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2a\", \"unit\": \"μM\"}", "{\"value\": \"41\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2a\", \"unit\": \"μM\"}", "{\"value\": \"179\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2a\", \"unit\": \"μM\"}", "{\"value\": \"18\", \"type\": \"Other\"}", "{\"value\": \"7.9\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2b\", \"unit\": \"μM\"}", "{\"value\": \"8.1\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2b\", \"unit\": \"μM\"}", "{\"value\": \"23.3\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2b\", \"unit\": \"μM\"}", "{\"value\": \"224\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2b\", \"unit\": \"μM\"}", "{\"value\": \"28\", \"type\": \"Other\"}", "{\"value\": \"17.8\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2c\", \"unit\": \"μM\"}", "{\"value\": \"7.4\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2c\", \"unit\": \"μM\"}", "{\"value\": \"20.8\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2c\", \"unit\": \"μM\"}", "{\"value\": \"224\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2c\", \"unit\": \"μM\"}", "{\"value\": \"30\", \"type\": \"Other\"}", "{\"value\": \"7.7\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2d\", \"unit\": \"μM\"}", "{\"value\": \"8.3\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2d\", \"unit\": \"μM\"}", "{\"value\": \"26\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2d\", \"unit\": \"μM\"}", "{\"value\": \"166\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2d\", \"unit\": \"μM\"}", "{\"value\": \"20\", \"type\": \"Other\"}", "{\"value\": \"12.1\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2e\", \"unit\": \"μM\"}", "{\"value\": \"7.4\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2e\", \"unit\": \"μM\"}", "{\"value\": \"21\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2e\", \"unit\": \"μM\"}", "{\"value\": \"166\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2e\", \"unit\": \"μM\"}", "{\"value\": \"22\", \"type\": \"Other\"}", "{\"value\": \"26.5\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2f\", \"unit\": \"μM\"}", "{\"value\": \"12.0\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2f\", \"unit\": \"μM\"}", "{\"value\": \"107\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2f\", \"unit\": \"μM\"}", "{\"value\": \"8.9\", \"type\": \"Other\"}", "{\"value\": \"21.2\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2g\", \"unit\": \"μM\"}", "{\"value\": \"5.1\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2g\", \"unit\": \"μM\"}", "{\"value\": \"11.8\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2g\", \"unit\": \"μM\"}", "{\"value\": \"233\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2g\", \"unit\": \"μM\"}", "{\"value\": \"46\", \"type\": \"Other\"}", "{\"value\": \"14.7\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2h\", \"unit\": \"μM\"}", "{\"value\": \"4.8\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2h\", \"unit\": \"μM\"}", "{\"value\": \"19.6\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2h\", \"unit\": \"μM\"}", "{\"value\": \"186\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2h\", \"unit\": \"μM\"}", "{\"value\": \"39\", \"type\": \"Other\"}", "{\"value\": \"30.8\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2i\", \"unit\": \"μM\"}", "{\"value\": \"14.3\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2i\", \"unit\": \"μM\"}", "{\"value\": \"233\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2i\", \"unit\": \"μM\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"11\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2j\", \"unit\": \"μM\"}", "{\"value\": \"181\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2j\", \"unit\": \"μM\"}", "{\"value\": \"16\", \"type\": \"Other\"}", "{\"value\": \"8.1\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2k\", \"unit\": \"μM\"}", "{\"value\": \"25.0\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2k\", \"unit\": \"μM\"}", "{\"value\": \"226\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2k\", \"unit\": \"μM\"}", "{\"value\": \"28\", \"type\": \"Other\"}", "{\"value\": \"23.7\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2l\", \"unit\": \"μM\"}", "{\"value\": \"7.7\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2l\", \"unit\": \"μM\"}", "{\"value\": \"33.2\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2l\", \"unit\": \"μM\"}", "{\"value\": \"211\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2l\", \"unit\": \"μM\"}", "{\"value\": \"28\", \"type\": \"Other\"}", "{\"value\": \"36.3\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2m\", \"unit\": \"μM\"}", "{\"value\": \"7.3\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2m\", \"unit\": \"μM\"}", "{\"value\": \"31.2\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2m\", \"unit\": \"μM\"}", "{\"value\": \"169\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2m\", \"unit\": \"μM\"}", "{\"value\": \"23\", \"type\": \"Other\"}", "{\"value\": \"25.0\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2n\", \"unit\": \"μM\"}", "{\"value\": \"169\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2n\", \"unit\": \"μM\"}", "{\"value\": \"7\", \"type\": \"Other\"}", "{\"value\": \"25.4\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2o\", \"unit\": \"μM\"}", "{\"value\": \"13.9\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2o\", \"unit\": \"μM\"}", "{\"value\": \"138\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2o\", \"unit\": \"μM\"}", "{\"value\": \"9.9\", \"type\": \"Other\"}", "{\"value\": \"2.7\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2p\", \"unit\": \"μM\"}", "{\"value\": \"9.7\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2p\", \"unit\": \"μM\"}", "{\"value\": \"168\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2p\", \"unit\": \"μM\"}", "{\"value\": \"17\", \"type\": \"Other\"}", "{\"value\": \"6.2\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2q\", \"unit\": \"μM\"}", "{\"value\": \"20\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2q\", \"unit\": \"μM\"}", "{\"value\": \"181\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2q\", \"unit\": \"μM\"}", "{\"value\": \"29\", \"type\": \"Other\"}", "{\"value\": \"8.0\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2r\", \"unit\": \"μM\"}", "{\"value\": \"7.0\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2r\", \"unit\": \"μM\"}", "{\"value\": \"37\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2r\", \"unit\": \"μM\"}", "{\"value\": \"175\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2r\", \"unit\": \"μM\"}", "{\"value\": \"25\", \"type\": \"Other\"}", "{\"value\": \"6.4\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2s\", \"unit\": \"μM\"}", "{\"value\": \"160\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2s\", \"unit\": \"μM\"}", "{\"value\": \"25\", \"type\": \"Other\"}", "{\"value\": \"43.0\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"2t\", \"unit\": \"μM\"}", "{\"value\": \"4.5\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2t\", \"unit\": \"μM\"}", "{\"value\": \"11\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2t\", \"unit\": \"μM\"}", "{\"value\": \"44\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2t\", \"unit\": \"μM\"}", "{\"value\": \"9.7\", \"type\": \"Other\"}", "{\"value\": \"88.2\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2u\", \"unit\": \"μM\"}", "{\"value\": \"65.2\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"2u\", \"unit\": \"μM\"}", "{\"value\": \"155\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"2u\", \"unit\": \"μM\"}", "{\"value\": \"2.5\", \"type\": \"Other\"}", "{\"value\": \"3\", \"type\": \"Other\"}", "{\"value\": \"4.5\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"3\", \"unit\": \"μM\"}", "{\"value\": \"56\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"3\", \"unit\": \"μM\"}", "{\"value\": \"12\", \"type\": \"Other\"}", "{\"value\": \"4\", \"type\": \"Other\"}", "{\"value\": \"15\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"4\", \"unit\": \"μM\"}", "{\"value\": \"34\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"4\", \"unit\": \"μM\"}", "{\"value\": \"192\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"4\", \"unit\": \"μM\"}", "{\"value\": \"13\", \"type\": \"Other\"}", "{\"value\": \"5\", \"type\": \"Other\"}", "{\"value\": \"80.8\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"5\", \"unit\": \"μM\"}", "{\"value\": \"160\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"5\", \"unit\": \"μM\"}", "{\"value\": \"2.3\", \"type\": \"Other\"}", "{\"value\": \"21.0\", \"type\": \"IC50\", \"target\": \"NS5B\", \"treatment\": \"1h\", \"unit\": \"μM\"}", "{\"value\": \"7.5\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"1h\", \"unit\": \"μM\"}", "{\"value\": \"42.0\", \"type\": \"EC50\", \"target\": \"NS5B\", \"treatment\": \"1h\", \"unit\": \"μM\"}", "{\"value\": \"370\", \"type\": \"CC50\", \"target\": \"xx\", \"treatment\": \"1h\", \"unit\": \"μM\"}", "{\"value\": \"49\", \"type\": \"Other\"}" ] }
PMC4203399
tbl2
<table-wrap><label>Table 2</label><caption><title>NS5B Mutant Inhibition Parameters for Derivative 2aa</title></caption><table><colgroup><col/><col/><col/><col/></colgroup><thead> <tr> <th>binding site</th> <th>NS5B mutant</th> <th>IC50 (μM)</th> <th>fold change</th> </tr></thead><tbody> <tr> <td>PSI</td> <td>M414T</td> <td>127.7 ± 5.5</td> <td>29.7</td> </tr> <tr> <td>TSI</td> <td>P495L</td> <td>5.1 ± 0.3</td> <td>1.2</td> </tr> <tr> <td>TSII</td> <td>M423T</td> <td>9.3 ± 1.5</td> <td>2.2</td> </tr></tbody></table><table-wrap-foot><fn><label>a</label><p>The IC50 values were evaluated against the indicated NS5B mutants as described for the wild-type NS5B and represents an average ± SD of two independent experiments in duplicate. Fold change is indicated relative to NS5B WT (IC50 = 4.3 μM).</p></fn></table-wrap-foot></table-wrap>
{ "cell_value": [ "127.7", "29.7", "5.1", "1.2", "9.3", "2.2" ], "cell_raw": [ "127.7 ± 5.5", "29.7", "5.1 ± 0.3", "1.2", "9.3 ± 1.5", "2.2" ], "cell_index": [ "CA(1,2)", "CA(1,3)", "CA(2,2)", "CA(2,3)", "CA(3,2)", "CA(3,3)" ], "cell_row_idx": [ 1, 1, 2, 2, 3, 3 ], "cell_col_idx": [ 2, 3, 2, 3, 2, 3 ] }
{ "cell_index": [ "CA(1,2)", "CA(1,3)", "CA(2,2)", "CA(2,3)", "CA(3,2)", "CA(3,3)" ], "cell_record": [ "{\"value\": \"127.7\", \"type\": \"Other\"}", "{\"value\": \"29.7\", \"type\": \"Other\"}", "{\"value\": \"5.1\", \"type\": \"Other\"}", "{\"value\": \"1.2\", \"type\": \"Other\"}", "{\"value\": \"9.3\", \"type\": \"Other\"}", "{\"value\": \"2.2\", \"type\": \"Other\"}" ] }