tags
sequencelengths 5
204
| tokens
sequencelengths 5
204
|
---|---|
[
1,
2,
0,
0,
3,
4,
0,
0,
3,
0,
0,
0,
0,
0,
3,
0
] | [
"IL-2",
"gene",
"expression",
"and",
"NF-kappa",
"B",
"activation",
"through",
"CD28",
"requires",
"reactive",
"oxygen",
"production",
"by",
"5-lipoxygenase",
"."
] |
[
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
3,
0,
0,
0,
0,
0
] | [
"Activation",
"of",
"the",
"CD28",
"surface",
"receptor",
"provides",
"a",
"major",
"costimulatory",
"signal",
"for",
"T",
"cell",
"activation",
"resulting",
"in",
"enhanced",
"production",
"of",
"interleukin-2",
"(",
"IL-2",
")",
"and",
"cell",
"proliferation",
"."
] |
[
0,
5,
6,
6,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
3,
4,
0,
3,
4,
0,
3,
0,
0
] | [
"In",
"primary",
"T",
"lymphocytes",
"we",
"show",
"that",
"CD28",
"ligation",
"leads",
"to",
"the",
"rapid",
"intracellular",
"formation",
"of",
"reactive",
"oxygen",
"intermediates",
"(",
"ROIs",
")",
"which",
"are",
"required",
"for",
"CD28",
"-mediated",
"activation",
"of",
"the",
"NF-kappa",
"B",
"/",
"CD28-responsive",
"complex",
"and",
"IL-2",
"expression",
"."
] |
[
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
0
] | [
"Delineation",
"of",
"the",
"CD28",
"signaling",
"cascade",
"was",
"found",
"to",
"involve",
"protein",
"tyrosine",
"kinase",
"activity",
",",
"followed",
"by",
"the",
"activation",
"of",
"phospholipase",
"A2",
"and",
"5-lipoxygenase",
"."
] |
[
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
0,
3,
0,
0,
3,
4,
0,
0
] | [
"Our",
"data",
"suggest",
"that",
"lipoxygenase",
"metabolites",
"activate",
"ROI",
"formation",
"which",
"then",
"induce",
"IL-2",
"expression",
"via",
"NF-kappa",
"B",
"activation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0
] | [
"These",
"findings",
"should",
"be",
"useful",
"for",
"therapeutic",
"strategies",
"and",
"the",
"development",
"of",
"immunosuppressants",
"targeting",
"the",
"CD28",
"costimulatory",
"pathway",
"."
] |
[
0,
1,
2,
2,
0,
1,
2,
2,
2,
2,
2,
0,
0,
5,
0,
0,
0,
5,
6,
0
] | [
"The",
"peri-kappa",
"B",
"site",
"mediates",
"human",
"immunodeficiency",
"virus",
"type",
"2",
"enhancer",
"activation",
"in",
"monocytes",
"but",
"not",
"in",
"T",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Human",
"immunodeficiency",
"virus",
"type",
"2",
"(",
"HIV-2",
")",
",",
"like",
"HIV-1",
",",
"causes",
"AIDS",
"and",
"is",
"associated",
"with",
"AIDS",
"cases",
"primarily",
"in",
"West",
"Africa",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"HIV-1",
"and",
"HIV-2",
"display",
"significant",
"differences",
"in",
"nucleic",
"acid",
"sequence",
"and",
"in",
"the",
"natural",
"history",
"of",
"clinical",
"disease",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Consistent",
"with",
"these",
"differences",
",",
"we",
"have",
"previously",
"demonstrated",
"that",
"the",
"enhancer/promoter",
"region",
"of",
"HIV-2",
"functions",
"quite",
"differently",
"from",
"that",
"of",
"HIV-1",
"."
] |
[
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
3,
4,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
1,
2,
0,
5,
0,
5,
6,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
0,
1,
0,
1,
0,
0,
0,
1,
2,
0
] | [
"Whereas",
"activation",
"of",
"the",
"HIV-1",
"enhancer",
"following",
"T-cell",
"stimulation",
"is",
"mediated",
"largely",
"through",
"binding",
"of",
"the",
"transcription",
"factor",
"NF-kappa",
"B",
"to",
"two",
"adjacent",
"kappa",
"B",
"sites",
"in",
"the",
"HIV-1",
"long",
"terminal",
"repeat",
",",
"activation",
"of",
"the",
"HIV-2",
"enhancer",
"in",
"monocytes",
"and",
"T",
"cells",
"is",
"dependent",
"on",
"four",
"cis-acting",
"elements",
":",
"a",
"single",
"kappa",
"B",
"site",
",",
"two",
"purine-rich",
"binding",
"sites",
",",
"PuB1",
"and",
"PuB2",
",",
"and",
"a",
"pets",
"site",
"."
] |
[
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
0
] | [
"We",
"have",
"now",
"identified",
"a",
"novel",
"cis-acting",
"element",
"within",
"the",
"HIV-2",
"enhancer",
",",
"immediately",
"upstream",
"of",
"the",
"kappa",
"B",
"site",
",",
"designated",
"peri-kappa",
"B",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
7,
0,
0,
7,
8,
0
] | [
"This",
"site",
"is",
"conserved",
"among",
"isolates",
"of",
"HIV-2",
"and",
"the",
"closely",
"related",
"simian",
"immunodeficiency",
"virus",
",",
"and",
"transfection",
"assays",
"show",
"this",
"site",
"to",
"mediate",
"HIV-2",
"enhancer",
"activation",
"following",
"stimulation",
"of",
"monocytic",
"but",
"not",
"T-cell",
"lines",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0
] | [
"This",
"is",
"the",
"first",
"description",
"of",
"an",
"HIV-2",
"enhancer",
"element",
"which",
"displays",
"such",
"monocyte",
"specificity",
",",
"and",
"no",
"comparable",
"enhancer",
"element",
"has",
"been",
"clearly",
"defined",
"for",
"HIV-1",
"."
] |
[
0,
0,
3,
4,
0,
0,
0,
0,
0,
5,
6,
6,
0,
5,
6,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
6,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
5,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0
] | [
"While",
"a",
"nuclear",
"factor",
"(",
"s",
")",
"from",
"both",
"peripheral",
"blood",
"monocytes",
"and",
"T",
"cells",
"binds",
"the",
"peri-kappa",
"B",
"site",
",",
"electrophoretic",
"mobility",
"shift",
"assays",
"suggest",
"that",
"either",
"a",
"different",
"protein",
"binds",
"to",
"this",
"site",
"in",
"monocytes",
"versus",
"T",
"cells",
"or",
"that",
"the",
"protein",
"recognizing",
"this",
"enhancer",
"element",
"undergoes",
"differential",
"modification",
"in",
"monocytes",
"and",
"T",
"cells",
",",
"thus",
"supporting",
"the",
"transfection",
"data",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Further",
",",
"while",
"specific",
"constitutive",
"binding",
"to",
"the",
"peri-kappa",
"B",
"site",
"is",
"seen",
"in",
"monocytes",
",",
"stimulation",
"with",
"phorbol",
"esters",
"induces",
"additional",
",",
"specific",
"binding",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
5,
6,
0,
0,
0,
0,
0
] | [
"Understanding",
"the",
"monocyte-specific",
"function",
"of",
"the",
"peri-kappa",
"B",
"factor",
"may",
"ultimately",
"provide",
"insight",
"into",
"the",
"different",
"role",
"monocytes",
"and",
"T",
"cells",
"play",
"in",
"HIV",
"pathogenesis",
"."
] |
[
1,
2,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] | [
"E1A",
"gene",
"expression",
"induces",
"susceptibility",
"to",
"killing",
"by",
"NK",
"cells",
"following",
"immortalization",
"but",
"not",
"adenovirus",
"infection",
"of",
"human",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
5,
6,
0
] | [
"Adenovirus",
"(",
"Ad",
")",
"infection",
"and",
"E1A",
"transfection",
"were",
"used",
"to",
"model",
"changes",
"in",
"susceptibility",
"to",
"NK",
"cell",
"killing",
"caused",
"by",
"transient",
"vs",
"stable",
"E1A",
"expression",
"in",
"human",
"cells",
"."
] |
[
0,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
7,
8,
0
] | [
"Only",
"stably",
"transfected",
"target",
"cells",
"exhibited",
"cytolytic",
"susceptibility",
",",
"despite",
"expression",
"of",
"equivalent",
"levels",
"of",
"E1A",
"proteins",
"in",
"Ad-infected",
"targets",
"."
] |
[
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
1,
2,
0,
0,
3,
4,
4,
4,
0,
0,
5,
6,
0
] | [
"The",
"inability",
"of",
"E1A",
"gene",
"products",
"to",
"induce",
"cytolytic",
"susceptibility",
"during",
"infection",
"was",
"not",
"explained",
"by",
"an",
"inhibitory",
"effect",
"of",
"viral",
"infection",
"on",
"otherwise",
"susceptible",
"target",
"cells",
"or",
"by",
"viral",
"gene",
"effects",
"on",
"class",
"I",
"MHC",
"antigen",
"expression",
"on",
"target",
"cells",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
0
] | [
"This",
"differential",
"effect",
"of",
"E1A",
"expression",
"on",
"the",
"cytolytic",
"phenotypes",
"of",
"infected",
"and",
"stably",
"transfected",
"human",
"cells",
"suggests",
"that",
"human",
"NK",
"cells",
"provide",
"an",
"effective",
"immunologic",
"barrier",
"against",
"the",
"in",
"vivo",
"survival",
"and",
"neoplastic",
"progression",
"of",
"E1A-immortalized",
"cells",
"that",
"may",
"emerge",
"from",
"the",
"reservoir",
"of",
"persistently",
"infected",
"cells",
"in",
"the",
"human",
"host",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
4,
0
] | [
"Distinct",
"signaling",
"properties",
"identify",
"functionally",
"different",
"CD4",
"epitopes",
"."
] |
[
0,
3,
4,
0,
0,
3,
4,
0,
3,
4,
4,
4,
4,
4,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"CD4",
"coreceptor",
"interacts",
"with",
"non-polymorphic",
"regions",
"of",
"major",
"histocompatibility",
"complex",
"class",
"II",
"molecules",
"on",
"antigen-presenting",
"cells",
"and",
"contributes",
"to",
"T",
"cell",
"activation",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
3,
0,
0,
0,
0,
3,
4,
0
] | [
"We",
"have",
"investigated",
"the",
"effect",
"of",
"CD4",
"triggering",
"on",
"T",
"cell",
"activating",
"signals",
"in",
"a",
"lymphoma",
"model",
"using",
"monoclonal",
"antibodies",
"(",
"mAb",
")",
"which",
"recognize",
"different",
"CD4",
"epitopes",
"."
] |
[
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
3,
0,
0,
0
] | [
"We",
"demonstrate",
"that",
"CD4",
"triggering",
"delivers",
"signals",
"capable",
"of",
"activating",
"the",
"NF-AT",
"transcription",
"factor",
"which",
"is",
"required",
"for",
"interleukin-2",
"gene",
"expression",
"."
] |
[
0,
0,
3,
4,
0,
3,
4,
0,
0,
0,
0,
0,
0,
3,
4,
4,
3,
0,
3,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"Whereas",
"different",
"anti-CD4",
"mAb",
"or",
"HIV-1",
"gp120",
"could",
"all",
"trigger",
"activation",
"of",
"the",
"protein",
"tyrosine",
"kinases",
"p56lck",
"and",
"p59fyn",
"and",
"phosphorylation",
"of",
"the",
"Shc",
"adaptor",
"protein",
",",
"which",
"mediates",
"signals",
"to",
"Ras",
",",
"they",
"differed",
"significantly",
"in",
"their",
"ability",
"to",
"activate",
"NF-AT",
"."
] |
[
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Lack",
"of",
"full",
"activation",
"of",
"NF-AT",
"could",
"be",
"correlated",
"to",
"a",
"dramatically",
"reduced",
"capacity",
"to",
"induce",
"calcium",
"flux",
"and",
"could",
"be",
"complemented",
"with",
"a",
"calcium",
"ionophore",
"."
] |
[
0,
0,
0,
0,
0,
3,
0,
0,
3,
4,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0
] | [
"The",
"results",
"identify",
"functionally",
"distinct",
"epitopes",
"on",
"the",
"CD4",
"coreceptor",
"involved",
"in",
"activation",
"of",
"the",
"Ras/protein",
"kinase",
"C",
"and",
"calcium",
"pathways",
"."
] |
[
0,
0,
0,
0,
3,
4,
4,
3,
0,
0,
3,
4,
0
] | [
"Ligand-dependent",
"repression",
"of",
"the",
"erythroid",
"transcription",
"factor",
"GATA-1",
"by",
"the",
"estrogen",
"receptor",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0
] | [
"High-dose",
"estrogen",
"administration",
"induces",
"anemia",
"in",
"mammals",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
6,
6,
0,
0,
0,
0,
0
] | [
"In",
"chickens",
",",
"estrogens",
"stimulate",
"outgrowth",
"of",
"bone",
"marrow-derived",
"erythroid",
"progenitor",
"cells",
"and",
"delay",
"their",
"maturation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
3,
0
] | [
"This",
"delay",
"is",
"associated",
"with",
"down-regulation",
"of",
"many",
"erythroid",
"cell-specific",
"genes",
",",
"including",
"alpha-",
"and",
"beta-globin",
",",
"band",
"3",
",",
"band",
"4.1",
",",
"and",
"the",
"erythroid",
"cell-specific",
"histone",
"H5",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
7,
8,
8,
8,
8,
0
] | [
"We",
"show",
"here",
"that",
"estrogens",
"also",
"reduce",
"the",
"number",
"of",
"erythroid",
"progenitor",
"cells",
"in",
"primary",
"human",
"bone",
"marrow",
"cultures",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
5,
0
] | [
"To",
"address",
"potential",
"mechanisms",
"by",
"which",
"estrogens",
"suppress",
"erythropoiesis",
",",
"we",
"have",
"examined",
"their",
"effects",
"on",
"GATA-1",
",",
"an",
"erythroid",
"transcription",
"factor",
"that",
"participates",
"in",
"the",
"regulation",
"of",
"the",
"majority",
"of",
"erythroid",
"cell-specific",
"genes",
"and",
"is",
"necessary",
"for",
"full",
"maturation",
"of",
"erythrocytes",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
3,
4,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"We",
"demonstrate",
"that",
"the",
"transcriptional",
"activity",
"of",
"GATA-1",
"is",
"strongly",
"repressed",
"by",
"the",
"estrogen",
"receptor",
"(",
"ER",
")",
"in",
"a",
"ligand-dependent",
"manner",
"and",
"that",
"this",
"repression",
"is",
"reversible",
"in",
"the",
"presence",
"of",
"4-hydroxytamoxifen",
"."
] |
[
3,
0,
0,
0,
3,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
3,
0
] | [
"ER",
"-mediated",
"repression",
"of",
"GATA-1",
"activity",
"occurs",
"on",
"an",
"artificial",
"promoter",
"containing",
"a",
"single",
"GATA-binding",
"site",
",",
"as",
"well",
"as",
"in",
"the",
"context",
"of",
"an",
"intact",
"promoter",
"which",
"is",
"normally",
"regulated",
"by",
"GATA-1",
"."
] |
[
3,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"GATA-1",
"and",
"ER",
"bind",
"to",
"each",
"other",
"in",
"vitro",
"in",
"the",
"absence",
"of",
"DNA",
"."
] |
[
0,
0,
0,
0,
0,
7,
8,
0,
3,
0,
3,
0,
0,
0,
0,
0,
0
] | [
"In",
"coimmunoprecipitation",
"experiments",
"using",
"transfected",
"COS",
"cells",
",",
"GATA-1",
"and",
"ER",
"associate",
"in",
"a",
"ligand-dependent",
"manner",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
3,
0
] | [
"Mapping",
"experiments",
"indicate",
"that",
"GATA-1",
"and",
"the",
"ER",
"form",
"at",
"least",
"two",
"contacts",
",",
"which",
"involve",
"the",
"finger",
"region",
"and",
"the",
"N-terminal",
"activation",
"domain",
"of",
"GATA-1",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"We",
"speculate",
"that",
"estrogens",
"exert",
"effects",
"on",
"erythropoiesis",
"by",
"modulating",
"GATA-1",
"activity",
"through",
"protein-protein",
"interaction",
"with",
"the",
"ER",
"."
] |
[
0,
0,
0,
0,
0,
0,
0
] | [
"(",
"ABSTRACT",
"TRUNCATED",
"AT",
"250",
"WORDS",
")"
] |
[
1,
2,
2,
2,
2,
0,
0
] | [
"Mouse",
"interleukin-2",
"receptor",
"alpha",
"gene",
"expression",
"."
] |
[
3,
0,
3,
0,
0,
0,
0,
1,
2,
0
] | [
"Interleukin-1",
"and",
"interleukin-2",
"control",
"transcription",
"via",
"distinct",
"cis-acting",
"elements",
"."
] |
[
0,
0,
0,
0,
3,
0,
3,
0,
0,
3,
0,
1,
2,
2,
2,
2,
2,
2,
2,
0,
0,
7,
8,
8,
8,
8,
0
] | [
"We",
"have",
"shown",
"that",
"interleukin-1",
"(",
"IL-1",
")",
"and",
"IL-2",
"control",
"IL-2",
"receptor",
"alpha",
"(",
"IL-2R",
"alpha",
")",
"gene",
"transcription",
"in",
"CD4-CD8-",
"murine",
"T",
"lymphocyte",
"precursors",
"."
] |
[
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
7,
8,
8,
0,
7,
0,
0
] | [
"Here",
"we",
"map",
"the",
"cis-acting",
"elements",
"that",
"mediate",
"interleukin",
"responsiveness",
"of",
"the",
"mouse",
"IL-2R",
"alpha",
"gene",
"using",
"a",
"thymic",
"lymphoma-derived",
"hybridoma",
"(",
"PC60",
")",
"."
] |
[
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
3,
0,
3,
0,
0,
0
] | [
"The",
"transcriptional",
"response",
"of",
"the",
"IL-2R",
"alpha",
"gene",
"to",
"stimulation",
"by",
"IL-1",
"+",
"IL-2",
"is",
"biphasic",
"."
] |
[
3,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0
] | [
"IL-1",
"induces",
"a",
"rapid",
",",
"protein",
"synthesis-independent",
"appearance",
"of",
"IL-2R",
"alpha",
"mRNA",
"that",
"is",
"blocked",
"by",
"inhibitors",
"of",
"NF-kappa",
"B",
"activation",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
9,
10,
10,
0
] | [
"It",
"also",
"primes",
"cells",
"to",
"become",
"IL-2",
"responsive",
"and",
"thereby",
"prepares",
"the",
"second",
"phase",
",",
"in",
"which",
"IL-2",
"induces",
"a",
"100-fold",
"further",
"increase",
"in",
"IL-2R",
"alpha",
"transcripts",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
1,
2,
2,
0,
0,
3,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
1,
2,
2,
2,
0
] | [
"Transient",
"transfection",
"experiments",
"show",
"that",
"several",
"elements",
"in",
"the",
"promoter-proximal",
"region",
"of",
"the",
"IL-2R",
"alpha",
"gene",
"contribute",
"to",
"IL-1",
"responsiveness",
",",
"most",
"importantly",
"an",
"NF-kappa",
"B",
"site",
"conserved",
"in",
"the",
"human",
"and",
"mouse",
"gene",
"."
] |
[
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0
] | [
"IL-2",
"responsiveness",
",",
"on",
"the",
"other",
"hand",
",",
"depends",
"on",
"a",
"78-nucleotide",
"segment",
"1.3",
"kilobases",
"upstream",
"of",
"the",
"major",
"transcription",
"start",
"site",
"."
] |
[
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
5,
6,
0,
0,
3,
4,
0,
0,
0,
0,
0
] | [
"This",
"segment",
"functions",
"as",
"an",
"IL-2-inducible",
"enhancer",
"and",
"lies",
"within",
"a",
"region",
"that",
"becomes",
"DNase",
"I",
"hypersensitive",
"in",
"normal",
"T",
"cells",
"in",
"which",
"IL-2R",
"alpha",
"expression",
"has",
"been",
"induced",
"."
] |
[
3,
0,
0,
0,
0,
1,
0,
0,
1,
0
] | [
"IL-2",
"responsiveness",
"requires",
"three",
"distinct",
"elements",
"within",
"the",
"enhancer",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0
] | [
"Two",
"of",
"these",
"are",
"potential",
"binding",
"sites",
"for",
"STAT",
"proteins",
"."
] |
[
5,
6,
0,
0,
0,
0,
3,
4,
0
] | [
"Hematopoietic",
"lineage",
"commitment",
":",
"role",
"of",
"transcription",
"factors",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0
] | [
"This",
"review",
"focuses",
"on",
"the",
"roles",
"of",
"transcription",
"factors",
"in",
"hematopoietic",
"lineage",
"commitment",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
5,
6,
6,
0
] | [
"A",
"brief",
"introduction",
"to",
"lineage",
"commitment",
"and",
"asymmetric",
"cell",
"division",
"is",
"followed",
"by",
"a",
"discussion",
"of",
"several",
"methods",
"used",
"to",
"identify",
"transcription",
"factors",
"important",
"in",
"specifying",
"hematopoietic",
"cell",
"types",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
6,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0
] | [
"Next",
"is",
"presented",
"a",
"discussion",
"of",
"the",
"use",
"of",
"embryonic",
"stem",
"cells",
"in",
"the",
"analysis",
"of",
"hematopoietic",
"gene",
"expression",
"and",
"the",
"use",
"of",
"targeted",
"gene",
"disruption",
"to",
"analyze",
"the",
"role",
"of",
"transcription",
"factors",
"in",
"hematopoiesis",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
5,
6,
6,
6,
6,
6,
6,
0,
0,
0
] | [
"Finally",
",",
"the",
"status",
"of",
"our",
"current",
"knowledge",
"concerning",
"the",
"roles",
"of",
"transcription",
"factors",
"in",
"the",
"commitment",
"to",
"erythroid",
",",
"myeloid",
"and",
"lymphoid",
"cell",
"types",
"is",
"summarized",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
3,
0,
0,
0,
3,
0
] | [
"Epstein-Barr",
"virus",
"replicative",
"gene",
"transcription",
"during",
"de",
"novo",
"infection",
"of",
"human",
"thymocytes",
":",
"simultaneous",
"early",
"expression",
"of",
"BZLF-1",
"and",
"its",
"repressor",
"RAZ",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
5,
6,
0
] | [
"Epstein-Barr",
"virus",
"(",
"EBV",
")",
"is",
"known",
"to",
"infect",
"B",
"cells",
"and",
"epithelial",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0
] | [
"We",
"and",
"others",
"have",
"shown",
"that",
"EBV",
"can",
"also",
"infect",
"a",
"subset",
"of",
"thymocytes",
"."
] |
[
0,
0,
5,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0
] | [
"Infection",
"of",
"thymocytes",
"was",
"accompanied",
"by",
"the",
"appearance",
"of",
"linear",
"EBV",
"genome",
"within",
"8",
"hr",
"of",
"infection",
"."
] |
[
0,
0,
0,
1,
2,
0,
0,
0,
0
] | [
"Circularization",
"of",
"the",
"EBV",
"genome",
"was",
"not",
"detected",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"This",
"is",
"in",
"contrast",
"to",
"the",
"infection",
"in",
"B",
"cells",
"where",
"the",
"genome",
"can",
"circularize",
"within",
"24",
"hr",
"of",
"infection",
"."
] |
[
0,
0,
0,
0,
3,
4,
4,
4,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"appearance",
"of",
"the",
"BamHI",
"ZLF-1",
"gene",
"product",
",",
"ZEBRA",
",",
"by",
"RT-PCR",
",",
"was",
"observed",
"within",
"8",
"hr",
"of",
"infection",
"."
] |
[
0,
0,
0,
0,
0,
3,
4,
0,
3,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0
] | [
"The",
"appearance",
"of",
"a",
"novel",
"fusion",
"transcript",
"(",
"RAZ",
")",
",",
"which",
"comprised",
"regions",
"of",
"the",
"BZLF-1",
"locus",
"and",
"the",
"adjacent",
"BRLF-1",
"locus",
",",
"was",
"detected",
"by",
"RT-PCR",
"."
] |
[
3,
4,
0,
0,
0,
0,
0,
5,
0,
0,
0
] | [
"ZEBRA",
"protein",
"was",
"also",
"identified",
"in",
"infected",
"thymocytes",
"by",
"immunoprecipitation",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
5,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
5,
6,
6,
6,
0
] | [
"In",
"addition",
",",
"we",
"demonstrated",
"that",
"the",
"EBNA-1",
"gene",
"in",
"infected",
"thymocytes",
"was",
"transcribed",
"from",
"the",
"Fp",
"promoter",
",",
"rather",
"than",
"from",
"the",
"Cp/Wp",
"promoter",
"which",
"is",
"used",
"in",
"latently",
"infected",
"B",
"cells",
"."
] |
[
0,
0,
3,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
1,
2,
0,
0,
5,
0
] | [
"Transcripts",
"encoding",
"gp350/220",
",",
"the",
"major",
"coat",
"protein",
"of",
"EBV",
",",
"were",
"identified",
",",
"but",
"we",
"did",
"not",
"find",
"any",
"evidence",
"of",
"transcription",
"from",
"the",
"LMP-2A",
"or",
"EBER-1",
"loci",
"in",
"infected",
"thymocytes",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
5,
6,
0
] | [
"These",
"observations",
"suggest",
"that",
"de",
"novo",
"EBV",
"infection",
"of",
"thymocytes",
"differs",
"from",
"infection",
"of",
"B",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"The",
"main",
"difference",
"is",
"that",
"with",
"thymocytes",
",",
"no",
"evidence",
"could",
"be",
"found",
"that",
"the",
"virus",
"ever",
"circularizes",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0
] | [
"Rather",
",",
"EBV",
"remains",
"in",
"a",
"linear",
"configuration",
"from",
"which",
"replicative",
"genes",
"are",
"transcribed",
"."
] |
[
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
3,
0
] | [
"Identification",
"and",
"purification",
"of",
"human",
"Stat",
"proteins",
"activated",
"in",
"response",
"to",
"interleukin-2",
"."
] |
[
0,
0,
3,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"A",
"key",
"cytokine",
"induced",
"during",
"the",
"immune",
"response",
"is",
"IL-2",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Following",
"T",
"cell",
"activation",
",",
"the",
"genes",
"encoding",
"IL-2",
"and",
"the",
"various",
"chains",
"of",
"its",
"receptor",
"are",
"transcriptionally",
"induced",
"."
] |
[
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
5,
6,
0
] | [
"In",
"turn",
",",
"secreted",
"IL-2",
"serves",
"to",
"stimulate",
"the",
"proliferation",
"and",
"differentiation",
"of",
"T",
"lymphocytes",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"Several",
"recent",
"studies",
"have",
"implicated",
"Jak",
"kinases",
"in",
"the",
"signaling",
"pathway",
"induced",
"by",
"IL-2",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
3,
0
] | [
"Following",
"this",
"lead",
",",
"we",
"set",
"out",
"to",
"identify",
"transcription",
"factors",
"induced",
"in",
"response",
"to",
"IL-2",
"."
] |
[
5,
6,
6,
6,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0
] | [
"Human",
"peripheral",
"blood",
"lymphocytes",
"were",
"observed",
"to",
"contain",
"several",
"IL-2",
"-inducible",
"DNA",
"binding",
"activities",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
0,
0,
7,
0
] | [
"Similar",
"activities",
"were",
"also",
"observed",
"in",
"a",
"transformed",
"human",
"lymphocyte",
"line",
",",
"termed",
"YT",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
5,
6,
6,
6,
0
] | [
"We",
"have",
"purified",
"these",
"activities",
"and",
"found",
"that",
"the",
"principal",
"IL-2-inducible",
"component",
"bears",
"significant",
"relatedness",
"to",
"a",
"prolactin-induced",
"transcription",
"factor",
"first",
"identified",
"in",
"sheep",
"mammary",
"gland",
"tissue",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0
] | [
"We",
"hypothesize",
"that",
"activation",
"of",
"this",
"protein",
",",
"designated",
"hStat5",
",",
"helps",
"govern",
"the",
"biological",
"effects",
"of",
"IL-2",
"during",
"the",
"immune",
"response",
"."
] |
[
3,
0,
0,
3,
4,
4,
4,
0,
3,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"E2F-1",
"and",
"a",
"cyclin-like",
"DNA",
"repair",
"enzyme",
",",
"uracil-DNA",
"glycosylase",
",",
"provide",
"evidence",
"for",
"an",
"autoregulatory",
"mechanism",
"for",
"transcription",
"."
] |
[
0,
3,
4,
4,
4,
0,
3,
0,
0,
0,
3,
0,
0,
0,
0,
3,
4,
4,
1,
2,
2,
2,
2,
2,
0,
7,
8,
8,
8,
8,
8,
0
] | [
"The",
"cell",
"cycle-dependent",
"transcription",
"factor",
",",
"E2F-1",
",",
"regulates",
"the",
"cyclin",
"-like",
"species",
"of",
"the",
"DNA",
"repair",
"enzyme",
"uracil-DNA",
"glycosylase",
"(",
"UDG",
")",
"gene",
"in",
"human",
"osteosarcoma",
"(",
"Saos-2",
")",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
3,
0,
0,
1,
2,
0,
0,
1,
2,
0
] | [
"We",
"demonstrate",
",",
"through",
"the",
"deletion",
"of",
"the",
"human",
"UDG",
"promoter",
"sequences",
",",
"that",
"expression",
"of",
"E2F-1",
"activates",
"the",
"UDG",
"promoter",
"through",
"several",
"E2F",
"sites",
"."
] |
[
0,
1,
2,
2,
2,
0,
3,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
3,
4,
0,
0,
0,
0
] | [
"The",
"major",
"putative",
"downstream",
"site",
"for",
"E2F",
",",
"located",
"in",
"the",
"first",
"exon",
",",
"serves",
"as",
"a",
"target",
"for",
"E2F-1/DP1",
"complex",
"binding",
"in",
"vitro",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
4,
0,
3,
0
] | [
"We",
"also",
"provide",
"evidence",
"for",
"the",
"functional",
"relationship",
"between",
"the",
"cyclin-like",
"UDG",
"gene",
"product",
"and",
"E2F",
"."
] |
[
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
3,
0,
0,
0
] | [
"High",
"levels",
"of",
"UDG",
"expression",
"in",
"a",
"transient",
"transfection",
"assay",
"result",
"in",
"the",
"down-regulation",
"of",
"transcriptional",
"activity",
"through",
"elements",
"specific",
"for",
"E2F",
"-mediated",
"transcription",
"."
] |
[
0,
0,
3,
0,
7,
8,
8,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Overexpression",
"of",
"UDG",
"in",
"Saos",
"2",
"cells",
"was",
"observed",
"to",
"delay",
"growth",
"late",
"in",
"G1",
"phase",
"and",
"transiently",
"arrest",
"these",
"cells",
"from",
"progressing",
"into",
"the",
"S",
"phase",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] | [
"This",
"hypothetical",
"model",
"integrates",
"one",
"mechanism",
"of",
"DNA",
"repair",
"with",
"the",
"cell",
"cycle",
"control",
"of",
"gene",
"transcription",
",",
"likely",
"through",
"E2F",
"."
] |
[
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
3,
0,
0,
0,
0
] | [
"This",
"implicates",
"E2F",
"as",
"a",
"multifunctional",
"target",
"for",
"proteins",
"and",
"enzymes",
",",
"possibly",
",",
"responsive",
"to",
"DNA",
"damage",
"through",
"the",
"negative",
"effect",
"of",
"UDG",
"on",
"E2F",
"-mediated",
"transcriptional",
"activity",
"."
] |
[
0,
0,
0,
0,
0,
3,
0,
0,
0,
3,
0,
3,
0,
0,
7,
8,
8,
8,
0
] | [
"Cellular",
"and",
"molecular",
"mechanisms",
"of",
"IFN-gamma",
"production",
"induced",
"by",
"IL-2",
"and",
"IL-12",
"in",
"a",
"human",
"NK",
"cell",
"line",
"."
] |
[
3,
0,
3,
0,
0,
0,
0,
3,
4,
0,
0,
0,
5,
6,
0,
5,
6,
6,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0
] | [
"Interferon-gamma",
"(",
"IFN-gamma",
")",
"is",
"an",
"important",
"immunoregulatory",
"protein",
"produced",
"predominantly",
"by",
"T",
"cells",
"and",
"large",
"granular",
"lymphocytes",
"(",
"LGL",
")",
"in",
"response",
"to",
"different",
"extracellular",
"signals",
"."
] |
[
0,
0,
0,
0,
3,
0,
3,
0,
0,
3,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
5,
6,
0,
5,
0
] | [
"In",
"particular",
",",
"two",
"interleukins",
"(",
"ILs",
")",
",",
"IL-2",
"and",
"IL-12",
",",
"have",
"been",
"shown",
"to",
"be",
"potent",
"inducers",
"of",
"IFN-gamma",
"gene",
"expression",
"in",
"both",
"T",
"cells",
"and",
"LGL",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
8,
8,
8,
8,
0,
0,
0,
0,
0,
0,
0
] | [
"Although",
"it",
"has",
"been",
"reported",
"that",
"there",
"are",
"some",
"T",
"cell",
"lines",
"that",
"produce",
"IFN-gamma",
"in",
"response",
"to",
"IL-2",
"and",
"IL-12",
"stimulation",
",",
"there",
"has",
"as",
"yet",
"been",
"no",
"report",
"of",
"a",
"natural",
"killer",
"(",
"NK",
")",
"cell",
"line",
"that",
"responds",
"in",
"a",
"similar",
"manner",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
7,
8,
8,
0,
0,
5,
6,
6,
0,
0,
0,
0,
3,
0,
3,
0,
0,
0,
0,
0,
0,
3,
0,
3,
4,
4,
0,
3,
0,
0,
0,
0,
0,
0,
0
] | [
"In",
"this",
"report",
"we",
"present",
"evidence",
"that",
"the",
"cell",
"line",
"NK3.3",
"derived",
"from",
"human",
"NK",
"cells",
",",
"responds",
"to",
"both",
"IL-2",
"and",
"IL-12",
",",
"as",
"measured",
"by",
"increases",
"in",
"IFN-gamma",
"and",
"granulocyte-macrophage",
"colony-stimulating",
"factor",
"(",
"GM-CSF",
")",
"cytoplasmic",
"mRNA",
"and",
"protein",
"expression",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
0,
3,
0,
0,
0,
0,
0,
3,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
10,
10,
10,
0
] | [
"In",
"addition",
",",
"when",
"used",
"together",
"IL-2",
"and",
"IL-12",
"synergized",
"in",
"the",
"induction",
"of",
"IFN-gamma",
"and",
"GM-CSF",
"and",
"this",
"synergy",
"was",
"attributed",
"to",
"an",
"increased",
"accumulation",
"and",
"stability",
"of",
"the",
"IFN-gamma",
"and",
"GM-CSF",
"mRNAs",
"."
] |
[
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
3,
0,
7,
8,
0
] | [
"To",
"investigate",
"the",
"signaling",
"pathways",
"involved",
"in",
"the",
"gene",
"induction",
",",
"five",
"inhibitors",
",",
"cyclosporin",
"A",
"(",
"CsA",
")",
",",
"transforming",
"growth",
"factor-beta",
",",
"cycloheximide",
",",
"genistein",
",",
"and",
"staurosporine",
"A",
",",
"were",
"used",
"in",
"analyzing",
"the",
"effects",
"of",
"IL-2",
"and",
"IL-12",
"on",
"NK3.3",
"cells",
"."
] |
[
0,
0,
0,
0,
0,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
9,
10,
10,
10,
10,
0
] | [
"The",
"results",
"suggest",
"that",
"activation",
"of",
"protein",
"kinase",
"C",
",",
"but",
"not",
"new",
"protein",
"synthesis",
",",
"is",
"required",
"for",
"IL-2",
"induction",
"of",
"IFN-gamma",
"and",
"GM-CSF",
"cytoplasmic",
"mRNA",
"."
] |