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qualiti life liver transplant first experi serbia background liver transplant lt effect treatment patient end stage liver diseas dramat effect patient qualiti life qol aim studi evalu impact socio demograph clinic factor differ qol domain patient underw orthotop lt method cross section studi includ total patient underw lt socio demograph clinic data record patient qol estim use two valid questionnair item short form health survey sf chronic liver diseas questionnair cldq result male patient obtain signific higher score women domain general health percept vs p physic compon summari vs p signific differ domain sf cldq etiolog under liver diseas presenc post transplant complic show effect score valu sf cdlq domain p time lt show negat medium correl role limit due physic health problem p signific correl note item sf cldq conclus men higher score domain general health percept physic compon summari follow lt women increas time lt patient experi decreas limit due physic health problem audit improv qol essenti part individu long term health care approach lt patient

D016031;D008107

T061;T047;T033

practic upstream race base trauma care train veteran health administr nurs practition problem advanc practic regist nurs aprn employ veteran health administr vha lack race base trauma train veteran experienc psycholog physiolog emot trauma vha respons health cultur divers patient popul complex health condit aprn without prior militari experi may troubl obtain accur histori physic exam due inexperi militari cross cultur environ qualiti improv pilot project aim incorpor race base trauma train new adult geriatr acut care nurs practition agacnp fellowship curriculum studi question acut geriatr acut care nurs practitiion effect race base trauma train compet confid provid care veteran hospit method prospect descript design util purpos sampl senior adult geriatr nurs practition agnp student due unforeseen circumst hire agacnp pilot first week new acut care fellowship pilot program outcom measur includ evalu skill identifi racial differ confid appli cultur sensit care result particip n self report confid increas provid cultur compet race base trauma care improv identifi race base differ complet pilot implic result indic improv confid compet provid race base trauma care within week continu train evalu throughout month fellowship recommend

D014728;D009722;D004632

T061;T098;T093;T097;T058

famili health patient heart failur famili member first covid lockdown background famili health play vital role self care lifestyl modif famili live heart failur object investig famili health patient heart failur famili member first covid lockdown method cross section studi design includ particip particip first covid lockdown independ test conduct comparison mean score famili health dimens result signific differ total score famili health first covid lockdown compar first covid lockdown patient famili member howev valu ill dimens famili health patient ill dimens famili member signific decreas first covid lockdown conclus studi indic posit negat impact covid lockdown famili health implic nurs result may help nurs identifi vulner patient low level famili health tailor best support

D000086382;D006333

T047;T046;T067

prepar three dimension porous graphen hydrotherm chemic reduct ascorb acid electrochem properti three dimension porous graphen pg attract much attent due excel electrochem perform chemic reduct one common method prepar porous graphen order develop green facil method prepar three dimension porous graphen paper pg fabric reduct graphen oxid go ascorb acid aa reduct hydrotherm condit base non toxic non flammabl mild reduc perform ascorb acid found size distribut pore could control reduct time concentr aa solut pore size r r r rang respect found averag pore size volum increas along amount reduct optim condit reaction time h ratio go aa cv area obtain sampl r mv specif capacit pg electrod reach f g suitabl use supercapacitor

D006108

T196;T109

evalu day mortal patient undergo gastrointestin endoscopi tertiari hospit year retrospect survey despit intern guidelin recommend use mortal qualiti criterion gastrointestin gi procedur recent studi report data lack object report death caus rate follow gi endoscopi tertiari univers hospit

D016099;D006471

T061;T058;T046;T047

carbon nanotub base nanofluid devic fabric properti applic rapid develop nanofluid unexpect behavior bizarr properti discov bring possibl solv water energi problem carbon nanotub cnts nanoscal diamet ultrasmooth hydrophob surfac provid strong confin unusu water carbon coupl lead mani exot properti flow enhanc strong ion exclus ultrafast proton transport phase transit articl review recent progress cnt base nanofluid devic fabric properti applic moreov challeng opportun cnt base nanofluid devic discuss

D037742

T104;T073

improv icsi success rate follow root caus analysi use system behaviour chart devil detail fertil clinic observ reduct fresh intracytoplasm sperm inject icsi implant rate key perform indic kpi benchmark threshold monitor improv clinic perform icsi success year good icsi implant rate meet benchmark level root caus analysi rca conduct includ input extern observ review system process bundl recommend chang implement part improv cycl aim increas fresh icsi implant rate back benchmark qualiti improv qi methodolog tool use includ statist process control chart baselin saasoft measur includ standard clinic outcom data kpis track follow defin control clinic laboratori chang fresh icsi implant rate improv signific p chisq improv work limit design plan studi act pdsa cycl intervent bundl oppos small pdsa cycl singl chang therefor improv could attribut singular intervent within bundl took longer anticip see improv due impact pandem qi project highlight difficulti clinic low cycl volum sensit monitor kpi time respons way need accumul suffici data confid trendsconcern mean small clinic could less respons problem reactiv fals posit import dissemin learn improv work current agre standardis optim protocol icsi result clinic use slight differ approach limit publish report embryolog kpi track follow defin control laboratoryclin chang project provid use knowledg icsi improv intervent could effect within larger clinic higher cycl volum

D020554;D060891

T061;T080

preval associ factor anxieti among popul urban area china cross section studi studi conduct explor preval associ factor anxieti disord among popul urban area china

D001007;D001008

T184;T041;T048

indic optim diabet care burden diabet complic africa systemat review meta analysi contemporari data attain optim diabet treatment goal burden diabet complic adult popul type diabet africa lack aim document current status attain three key indic optim diabet care preval five diabet complic adult african popul type diabet

D003929;D003924;D017719;D012164;D058729

T047

efficaci neuromuscular electr stimul combin low high frequenc bodi composit peripher muscl function exercis toler patient chronic kidney diseas undergo haemodialysi protocol randomis doubl blind clinic trial neuromuscular electr stimul nmes adjunct strategi increas isol muscular strength endur wide investig patient chronic kidney diseas ckd undergo haemodialysi hd howev efficaci combin low high frequenc improv muscular strength endur unknown trial aim evalu efficaci combin nmes strategi popul

D004599;D051436

T061;T047

beatpain utah studi protocol pragmat randomis trial examin telehealth strategi provid non pharmacolog pain care person chronic low back pain receiv care feder qualifi health center although evid base guidelin recommend non pharmacolog treatment first line care chronic low back pain lbp uptak limit particular rural low incom ethnic divers communiti beatpain studi evalu implement compar effect two strategi provid non pharmacolog treatment chronic lbp studi use telehealth overcom access barrier person receiv care feder qualifi health centr fqhcs state utah

D017116;D017216;D020446

T184;T073;T092;T093;T047;T058

impact mobil phone hiv public stigma cross section pseudo panel analysi ghana hiv relat stigma still remain major barrier test signific burden peopl live hiv plwh sub saharan africa paper investig mobil phone ownership influenc hiv relat stigma

D040421;D015658

T047;T073

protocol open randomis control trial investig fibrin glue skin graft skin cancer figss skin cancer common diseas tropic oncolog resect typic requir reconstruct skin graft fibrin glue initi establish haemostat agent studi extens adhes skin graft burn studi aim investig use fibrin adhes split skin graft skin cancer

D002056;D012878

T191;T037

geometr uncertainti intracrani aneurysm ruptur status discrimin two site retrospect studi assess risk associ unruptur intracrani aneurysm ia essenti clinic decis make sever geometr risk paramet propos purpos howev perform paramet inconsist studi evalu perform robust geometr risk paramet two dataset compar uncertainti inher assess paramet quantifi interparamet correl

D002532;D017542

T047;T046;T190

individu level communiti level determin use matern health servic northwest ethiopia prospect follow studi use matern health servic import indic matern health socioeconom develop evid individu level communiti level determin use matern health servic benishangul gumuz region well known far henc studi fill gap

D008427

T058

humor respons sar cov vaccin haemodialysi patient match cohort sar cov vaccin crucial intervent infect control howev immun respons vaccin dialysi patient report moder compar healthi adult studi avail humor respons immunis dialysi patient compar well match control group conduct prospect cohort studi measur sar cov antibodi titr fukushima prefectur japan sinc septemb

D000086663;D000086382

T200;T047;T067

patient asplenia doctor experi implement prevent measur follow novel educ intervent qualit analysi explor patient asplenia general practition gps percept novel health action process approach hapa base educ intervent target increas adher post splenectomi sepsi pss prevent measur experi implement prevent measur follow intervent

D001291;D058005

T097;T041

efficaci safeti remifentanil dose titrat correct spontan hyperventil aneurysm subarachnoid haemorrhag protocol statist analysi prospect physiolog studi spontan hyperventil shv common aneurysm subarachnoid haemorrhag asah reduct arteri partial pressur carbon dioxid paco may chang brain physiolog haemodynam oxygen metabol may lead secondari brain injuri howev correct shv safe effect patient asah well investig aim studi investig efficaci safeti remifentanil dose titrat correct hyperventil asah well effect chang paco cerebr blood flow cbf

D013345

T047;T046

antibiot treatment follow surgic drainag perian abscess atlas protocol multicentr doubl blind placebo control randomis trial perian fistula burden diseas annual incid western countri crypto glandular fistula origin perian abscess despit adequ drainag recur result anal fistula major develop within month evid gut deriv bacteria play role develop perian fistula till common practic routin administ prophylact antibiot prevent anal fistula develop need studi establish whether ad antibiot treatment surgic drainag perian abscess result reduct perian fistula

D001004;D012003;D012871

T047;T020;T190

test reliabl compar paper chines electron version western ontario mcmaster univers osteoarthr index protocol randomis control clinic trial western ontario mcmaster univers osteoarthr index womac common use indic diseas specif outcom knee osteoarthr conveni reliabl two format paper base womac p womac electron womac e womac china p womac wide use though e womac yet untest studi aim test whether e womac consist p womac intervent

D020370

T047

prostat mri versus psa screen prostat cancer detect mvp studi randomis clinic trial object compar prostat cancer detect rate patient undergo serum prostat specif antigen psa vs magnet reson imag mri prostat cancer screen

D011471;D000086382

T047;T191;T067

effect price decis experi cigarett smoke among gambian children surviv analysi use gambia global youth tobacco survey data investig relationship cigarett price smoke experiment among children gambia therebi expand evid base like impact excis tax cigarett demand low incom middl incom countri

D000073865;D062789

T055;T073;T131;T109

nurs post stroke depress global systemat assess clinic practic guidelin post stroke depress psd common mental disord post stroke patient yet recommend relat nurs clinic practic guidelin cpgs systemat sort studi aim assess methodolog qualiti current cpgs relat psd develop algorithm use nurs process framework nurs

D003863;D020521

T184;T047;T048

mix method implement studi virtual cultur tailor diabet self manag programm african caribbean communiti heal south london scale across nhs region england studi protocol nation health servic insight prioritis programm establish acceler implement evalu innov support post pandem work support academ health scienc network nation institut health care research appli research collabor south london test evalu implement scale type diabet td interventiontd estim three time preval uk african caribbean communiti white european tackl ethnic inequ td healthcar access evid base cultur tailor self manag educ programm african caribbean adult healthi eat activ lifestyl diabet heal codevelop peopl live experi initi face face programm heal pivot virtual deliveri respons covid purpos studi explor feasibl accept virtual deliveri model heal south london factor affect scale across area england

D000073278;D003924;D000086382

T058;T067;T047

efficaci safeti human deriv neural stem cell patient ischaem stroke studi protocol randomis control trial stroke common caus neurolog disabl adult worldwid neural stem cell nsc transplant shown promis result treatment stroke anim experi pilot investig stem cell stroke phase phase trial show transplant highest dose million cell well toler preliminari clinic benefit also observ howev trial open label small sampl size furthermor human nscs hnscs intracerebr implant serious advers event consid relat surgic procedur therefor plan conduct doubl blind randomis control trial test safeti efficaci intranas inject hnscs

D000086382;D002545;D020521;D000083242;D058953

T047;T046;T025;T067

reirradi option previous irradi prostat cancer ro pip feasibl studi investig toxic outcom follow reirradi stereotact bodi radiotherapi sbrt versus high dose rate brachytherapi hdr bt radiotherapi common curat treatment non metastat prostat cancer howev patient develop local recurr within year patient undergo potenti curat treatment includ salvag surgeri brachytherapi bt extern beam radiotherapi high intens focus ultrasound cryotherapi systemat review show high dose rate hdr bt stereotact bodi radiotherapi sbrt best outcom term biochem control lowest side effect reirradi option previous irradi prostat cancer ro pip trial aim determin feasibl recruit trial randomis patient salvag hdr bt sbrt provid prospect data patient record toxic outcom inform futur phase iii trial

D001918;D016634;D000069475;D011471

T061;T191

covid age mortal curv flatter develop countri evid cross section observ studi popul level offici death count excess death estim previous studi found pattern flatter covid age mortal curv among low incom middl incom countri lmic use offici covid death count studi examin question compar age gradient covid mortal broad set countri use offici covid death count excess mortal estim

D000086382

T047;T067

use communiti engag intervent improv child immunis low incom middl incom countri systemat review meta analysi support evid inform decis make systemat examin effect cost effect communiti engag intervent routin childhood immunis outcom low incom middl incom countri lmic identifi contextu design implement featur associ effect

D003906;D014611

T061;T080

subcapsular renal haematoma ureteroscop lithotripsi singl centr retrospect studi china investig incid predispos factor diagnosi manag subcapsular renal haematoma srh ureteroscop lithotripsi ursl

D014514;D008096;D006869

T061;T047

cerebr cognit modif retir profession soccer player tc foot protocol transvers analyt studi soccer popular sport world contact sport carri risk exposur repeat head impact form subconcuss defin minim brain injuri follow head impact symptom concuss suggest exposur repetit subconcuss event result long term neurophysiolog modif later develop chronic traumat encephalopathi consequ repeat impact remain controversi larg unexplor context soccer player

D012916;D001265;D001924

T056;T037

prospect cohort studi prevent mother child transmiss hepat b infect month follow hepat b expos infant ile ife nigeria elimin mother child transmiss mtct hepat b virus hbv central target reduc hepat b infect children nigeria account global burden intervent studi prevent mtct hbv hard avail studi aim assess impact prevent mtct intervent vertic transmiss hbv among pregnant women nigeria

D011251;D006509;D019694

T047

women prefer appli share decis make breast cancer screen discret choic experi analys women state prefer establish relat import attribut share decis make sdm willing pay wtp participatori care breast cancer screen programm bcsp

D055088;D001943

T060;T058;T191

retrospect studi impact covid lockdown patient type diabet northern jordan covid pandem complet lockdown citi one measur implement govern worldwid lockdown signific impact peopl lifestyl access utilis health servic studi aim assess impact lockdown glycaem control among patient type diabet mellitus tdm

D003924;D000086382

T047;T067

sex differ health relat qualiti life trajectori follow myocardi infarct nation longitudin cohort studi investig sex base differ baselin valu longitudin trajectori health relat qualiti life hrqol larg cohort myocardi infarct mi survivor adjust import factor

D011788;D009203

T078;T047

incid predictor mortal among adolesc antiretrovir therapi amhara region ethiopia retrospect cohort analysi studi aim assess incid predictor mortal adolesc receiv antiretrovir therapi art ethiopia amhara region

D015658

T047

evalu emot centric psycholog intervent chronic pain protocol systemat review meta analysi chronic pain defin pain persist longer month unpleas sensori experi persist negat emot emot comorbid depress anxieti plagu peopl chronic pain lead worsen pain intens increas disabl cognit behaviour therapi cbt gold standard psycholog treatment recent evid highlight cbt lack efficaci physic emot aspect chronic pain increas research investig emot centric psycholog therapi treatment modal vari intervent frequent target understand emot train individu emot adapt respons aim systemat review meta analysi quantifi efficaci emot centric intervent physic emot characterist chronic pain

D000083626;D059350

T061;T184;T047

complet matern continuum care associ antenat care attend previous pregnanc among women rural area gurag zone southwest ethiopia communiti base cross section studi matern continuum care cost effect intervent prevent pregnanc childbirth relat matern neonat mortal morbid studi aim investig preval complet matern continuum care associ antenat care anc attend previous pregnanc among women rural kebel gurag zone southwest ethiopia

D011295;D008427

T058

pilot trial compar covid public databas convent onlin search method literatur review use search engin result list manuscript provid content contain manuscript goal evalu user perform base criteria concept retriev accuraci effici use new databas system contain inform extract covid articl

D000086382

T047;T067

clinic util automat phenotyp annot unstructur clinic note intens care unit use clinic note contain inform document elsewher includ respons treatment clinic find crucial predict key outcom patient acut care studi propos automat annot phenotyp clinic note method captur essenti inform predict outcom intens care unit icu inform complementari typic use vital sign laboratori test result

D000069550;D007362

T093;T073;T066

synthesi photosensit base tetrapyrrol macrocycl combin antibiot dual inactiv bacteria combin photodynam therapi antibiot antimicrobi peptid inactiv bacteria area grow interest due synergist effect alreadi observ mani author shown effici dual antimicrobi therapi high depend structur photosensit tetrapyrrol macrocycl one promis result review articl recent literatur describ main microbiolog result concern dual inactiv bacteria none focus synthet process photosensit remark chemic versatil therefor herein present overview synthet methodolog prepar tetrapyrrol macrocycl conjug antibiot antimicrobi peptid use dual inactiv bacteria review divid two section concern physic coval combin ps antibioticcation peptid follow brief critic analysi correspond antimicrobi outcom

D017319;D010778

T061;T121;T039

comparison short interv low dose sild high dose cyclophosphamid suscept infect sle multicentrer world studi infect major caus death patient sle studi aim explor infect rate patient sle receiv low dose intraven cyclophosphamid iv cyc

D007166;D008180

T129;T047;T121

tobacco control polici work low incom middl incom countri realist synthesi burden tobacco use disproportion high low middl incom countri lmic scarc theoris work respect implement tobacco control polici set given complex natur tobacco control polici implement divers outcom wide implement polici defin role context conduct realist synthesi examin tobacco control polici implement lmic

D003906;D014026

T002;T080

prefer high carbohydr food chang children adolesc insulin induc hypoglycemia hypoglycemia elicit coordin counter regulatori neuroendocrin respons extent process involv increas drive eat togeth greater prefer food high carbohydr content unclear object examin effect children adolesc age year without diabet prior known experi hypoglycem episod

D001786;D007003

T047;T109

pregnanc induc pancreat insulin secret women long stand type diabet pregnanc entail pancreat adapt increas cell mass immunolog alter healthi women studi examin effect pregnanc cell function immunolog process long stand type diabet l td

D007328;D003922

T125;T121;T047;T116

peripartum cardiomyopathi rare caus acut heart failur woman earli present acut dyspnoea elev dimer week deliveri second child echocardiograph find show sign acut left ventricular failur mri confirm non ischaem dilat left heart failur compat peripartum cardiomyopathi antihormon therapi bromocriptin week intens heart failur therapi led amelior heart function within year full recoveri yet observ

D011249;D009202;D011644;D006333

T047;T046

hyperammonaemia syndrom dissemin ureaplasma parvum infect hyperammonaemia syndrom secondari ureaplasma spp infect well document post lung transplant popul report case man fifti hyperammonaemia syndrom secondari dissemin ureaplasma parvum infect occur context immunosuppress chronic graft versus host diseas six year follow allogen stem cell transplant diffus larg b cell lymphoma follow treatment u parvum septic arthriti ciprofloxacin doxycyclin patient experienc full neurolog recoveri continu suppress doxycyclin therapi recurr symptom date

D022124;D016869;D001170

T047

central venous sinus thrombosi young girl ulcer coliti paediatr central venous sinus thrombosi cvst uncommon import life threaten complic inflammatori bowel diseas ibd incid ibd increas last four decad paediatrician need awar complic current consensus children ibd receiv prophylact anticoagul present case young girl ulcer coliti suffer acut ischaem event secondari cvst acut flare diseas aim bring awar cvst ibd due high risk morbid mortal

D003093;D020246;D015212;D012851

T047;T046

patholog ankl fractur due brown tumour atyp present low serum vitamin normal parathyroid hormon bone profil osteoclastoma brown tumour name due increas vascular subsequ haemorrhag haemosiderin deposit give lesion reddish brown appear gross microscop examin due increas parathyroid hormon activ sever caus parathyroid adenoma renal impair low vitamin level lesion increas tendenc bone fractur challeng aspect diagnosi histolog diagnosi without immunohistochemistri imposs make without special stain brown tumour differenti giant cell tumour also class benign local destruct potenti malign transform tissu diagnosi confirm brown tumour aggress form treatment need general resolv under caus treat describ woman present local orthopaed servic patholog ankl fractur due brown tumour

D064386;D010002;D010282;D018212;D005598;D001859

T047;T191;T037;T046

hypoplast amelogenesi imperfecta bilater nephrolithiasi fgf mediat hypophosphataemia triad fama relat enamel renal syndrom enamel renal syndrom er due loss function lof mutat fama gene typic consist hypoplast amelogenesi imperfecta ai bilater nephrolithiasisnephrocalcinosi recent evid suggest fama interact famc increas activ thus lof mutat fama lead impair famc action famc golgi casein kinas phosphoryl fibroblast growth factor fgf prevent glycosyl make suscept degrad furin proteas consequ inactiv mutat famc lead increas concentr bioactiv intact fgf circul result hypophosphataemia lof mutat fama thus might also associ fgf mediat hypophosphataemia howev associ never report literatur describ first time triad ai bilater nephrolithiasi fgf mediat hypophosphataemia lof mutat fama suggest serum phosphat measur patient er avoid metabol skelet complic undiagnos henc untreat hypophosphataemia

D000567;D009397;D007669;D017674;D003746

T019;T047;T116;T123

whole exom sequenc base identif case cardiofaciocutan syndrom type benefit new sequenc technolog children neurodevelopment delay report case boy prolong diagnost workup global development delay alongsid feed difficulti failur thrive pulmonari stenosi macrocephali follow seri diagnost test first month life whole exom sequenc perform diagnos cardiofaciocutaen syndrom type global development delay common present general paediatr communiti paediatr clinic prompt search aetiolog describ child constel symptom often consist chromosom microarray neuroimag investig inborn error metabol develop genet test reduc cost clinic exom sequenc whole exom sequenc could test strategi offer comprehens first line test case demonstr featur cardiofaciocutan syndrom type ad valu modern genet technolog diagnosi children global development delay

D005183;D009421

T019;T047

integr genom wide polygen risk score non genet risk predict colorect cancer diagnosi use uk biobank data popul base cohort studi evalu benefit combin polygen risk score qcancer colorect cancer predict model non genet risk identifi peopl highest risk colorect cancer

D018070;D015179

T191;T093

understand digit disrupt health care ethnograph studi real time multidisciplinari clinic behavior new digit hospit understand electron medic record emr implement digit hospit focus retrospect work imagin experi multidisciplinari clinician rather work done behavior research question behavior multidisciplinari clinician transit new digit hospit

D006761;D000884

T090;T073;T093

diagnost reason neurogenet general approach establish definit diagnosi neurogenet diseas usual complex task howev like type clinic diagnost reason organ process develop consider diagnost hypothes may guid neurologist medic geneticist solv difficult task aim present review propos general method diagnost reason neurogenet definit main neurolog syndrom associ topograph diagnosi follow identif major secondari neurolog syndrom extraneurolog find inherit pattern also discuss general rule knowledg requir order physician request genet test inform interpret genet variant genet report guid request genet test accord organ model diagnost reason avail specif treatment clinician may find greater resolut efficaci diagnost investig shorten struggl patient definit diagnosi

D000072141;D005820

T060;T059;T097

static posturographi assist biofeedback exercis effect parkinson diseas parkinson diseas pd progress condit caus disord movement balanc

D010300

T047

track impact multipl sclerosi employ status develop questionnair multipl sclerosi ms negat effect employ status

D009103;D006233

T047;T101

bioflavonoid exert analges anti inflammatori effect via transient receptor potenti channel rat model pain uncomfort sensat bodi kaempferol flavonoid antinocicept effect transient receptor potenti trp channel character sensori system

D050051;D059787

T123;T116;T184

character persist headach attribut past stroke persist headach attribut past stroke phap controversi entiti recent includ third edit intern classif headach disord ichd despit describ retrospect studi

D020773;D020521

T047

evalu electrocardiograph p wave paramet predict long term atrial fibril patient acut ischem stroke electrocardiograph paramet p wave peak time pwpt p wave durat pwd p wave amplitud lead di util assess left atrial anomali link develop atrial fibril af differ cohort set

D001281;D000083242

T047;T046

stabl interact modul neuron oscil produc brain machin equilibrium close loop interact potenti regul ongo brain activ continu bind extern stimul specif dynam neural circuit achiev interact modul requir stabl brain machin feedback loop demonstr possibl maintain oscillatori brain activ desir state deliv stimul accur align time cycl develop fast algorithm respond cycl cycl basi stimul basal ganglia nuclei predetermin phase success cortic beta cycl parkinsonian rat use approach equilibrium emerg modifi brain signal feedback depend stimul pattern lead sustain amplif suppress oscil depend phase target beta amplif slow movement speed bias anim mode locomot togeth find show high respons phase depend stimul achiev stabl brain machin interact lead robust modul ongo behavior

D046690;D010300

T061;T047

head tail polymer vel protein underpin cold induc polycomb silenc flower control transcript silenc polycomb silenc machineri util read write mechan involv histon tail modif howev nucleat silenc long term stabl transmiss silenc state also requir p olycomb repress complex prc accessori protein whose molecular role poor understood arabidopsi vel protein accessori protein interact prc nucleat propag silenc flower locus c flc locus enabl earli flower spring report vel protein contain domain relat atyp four helix bundl engag spontan concentr depend head tail polymer assembl dynam biomolecular condens mutat block polymer vel domain prevent polycomb silenc flc plant vel protein thus facilit assembl dynam multival polycomb complex requir inherit silenc state

D017360;D029681

T116;T002

cardiac myosin specif autoimmun cell contribut immun checkpoint inhibitor associ myocard immun checkpoint inhibitor ici effect therapi various cancer howev induc immun relat advers event ira side effect myocard uncommon fatal ira caus ici treatment current mechan ici associ myocard unclear show develop myocard aj mice induc anti pd monoclon antibodi mab administr alon without tumor cell inocul immun viral infect mice myocard increas cardiac infiltr elev cardiac troponin level arrhythmia anti pd mab treatment also caus ira organ autoimmun cell recogn cardiac myosin activ increas mice myocard notabl cardiac myosin specif cell present naiv mice show phenotyp antigen experienc cell collect establish clinic relev mous model ici associ myocard find contribut cardiac myosin specif cell ici associ myocard develop pathogenesi

D009205;D000074322

T129;T047;T121;T116

larg scale optic dissect motor cortex connect show segreg organ mous forelimb represent rodent motor cortex rostral forelimb area rfa caudal forelimb area cfa major actor orchestr control complex forelimb movement howev intrins connect reciproc function organ still unclear limit understand brain coordin execut voluntari movement causal probe cortic connect activ pattern trigger transcrani optogenet stimul etholog relev complex movement exploit larg scale optic method awak mice result show specif activ featur movement class provid evid segreg function organ cfa rfa import identifi second discret later grasp represent area name later forelimb area lfa uniqu connect activ pattern therefor propos lfa distinct forelimb represent mous somatotop motor map

D009044

T023;T029

target mitfapaf axi salvag therapi mapk inhibitor resist melanoma melanoma dead form cancer character remark therapi resist analyz transcriptom mapk inhibitor sensit resist melanoma discov apaf negat regul mitf resist tumor studi identifi mitfapaf axi molecular driver mapk inhibitor resist drug reposit screen identifi quinacrin methylbenzethonium potent activ apoptosi context mimic drug resist mediat apaf inactiv compound show anti tumor activ vitro vivo model link suppress mitf function drug profound sensit melanoma cell mapk inhibitor regul key signal network melanoma includ mitfapaf axi signific activ two compound inhibit specif epigenet modul mitfapaf express histon deacetylas observ summari demonstr target mitfapaf axi may overcom resist could exploit potenti therapeut approach treat resist melanoma

D016879;D008545

T061;T191

nf loss function altern initi event pancreat ductal adenocarcinoma long stand question pancreat ductal adenocarcinoma pdac field whether altern genet alter could substitut oncogen kras mutat initi malign report neurofibromin nf inactiv bypass requir mutant kras pdac pathogenesi depth analysi pdac databas reveal various genet alter nf locus includ nonsens mutat occur predomin tumor wild type kras genet experi demonstr nf ablat culmin acinar ductal metaplasia earli step pdac furthermor nf haploinsuffici result dramat acceler kras gd driven pdac final show associ nf p orchestr pml mosaic analysi doubl marker demonstr concomit inactiv nf trp suffici trigger full blown pdac togeth find open exploratori framework apprehend mechanist paradigm pdac normal kras effect therapi avail

D021441;D010190

T191

singl cell transcriptom profil chromatin access reveal exhaust regulatori cd cell subset system lupus erythematosus system lupus erythematosus sle chronic autoimmun diseas cd cell known promot sle develop explor heterogen cd cell regulom associ sle pathogenesi perform assay transposas access chromatin high throughput sequenc atac seq singl cell transcriptom sequenc singl cell rna sequenc scrna seq peripher cd cell sle patient healthi control chromatin access signatur cd cell correl diseas sever generat singl cell transcriptom healthi sle cd cell reveal transcript dysfunct regulatori treg cell identifi two treg subpopul among ccr low cd hi treg subgroup featur type interferon induc function exhaust sle patient transcriptom level find sle treg mirror trend atac seq data studi establish rich empir foundat understand sle uncov previous unknown contribut treg exhaust like properti sle pathogenesi

D050378;D008180

T047;T025

mesoscal connect gene express empow whole brain model synuclein spread aggreg decay dynam emerg view regard neurodegen diseas discreet seed misfold protein lead widespread patholog howev mechan misfold protein seed distinct brain region caus differenti whole brain patholog remain elus use whole brain tissu clear high resolut imag longitudin map patholog synuclein pre form fibril inject model parkinson diseas clear brain differ time point diseas progress quantit segment regist standard atlas reveal distinct phase spread declin fit comput model paramet repres synuclein patholog spread aggreg decay gene express pattern longitudin dataset remark model general predict synuclein spread pattern sever distinct brain region even estim origin model empow mechanist understand accur predict diseas progress pave way develop test therapeut intervent

D051844;D000080874

T123;T047;T116

msrb regul gapdh oxid play programmat role shape metabol inflammatori signatur macrophag activ classic activ pro inflammatori macrophag generat naiv macrophag pro inflammatori cue dynam reprogram fuel metabol toward glycolysi increas intracellular reactiv oxygen speci ros level activ transcript releas pro inflammatori mediat studi mice lack methionin sulfoxid reductas msr b show result partial loss protein methionin reduct pro inflammatori macrophag creat uniqu metabol signatur character alter fuel util includ glucos pyruv chang also associ hyper inflamm least part due sustain oxid expos methionin residu glyceraldehyd phosphat dehydrogenas gapdh therebi induc gapdh aggreg inflammasom activ subsequ increas interleukin il secret sinc msrb knockout mice exhibit increas suscept lipopolysaccharid lps induc sepsi msrb gapdh axi may key molecular mechan protein redox homeostasi control metabol profil macrophag therebi regul function

D051150;D008262

T123;T126;T116;T043

diverg neurocircuitri dissoci two compon stress respons glucos mobil anxieti like behavior stress risk factor emot energi metabol disord howev neurocircuitri mechan emot initi glucos mobil under stress respons unclear demonstr photoactiv gad project anterior bed nucleus stria terminali abnst arcuat nucleus arc induc anxieti like behavior well acut hyperglycemia photoinhibit circuit anxiolyt block hyperglycemia induc restraint stress pharmacogenet inhibit arc gad raph obscurus nucleus rob photoactiv abnst gad arc circuit simultan lead signific hypoglycemia anxieti like behavior pharmacogenet inhibit arc gad nucleus solitari tract nts whilst photoactiv abnst gad arc circuit induc hyperglycemia result reveal abnst gad arc gad rob circuit recruit stress respons rapid glucos mobil abnst gad arc gad nts circuit behavior symptom stress respons studi identifi possibl general strategi neurocircuitri structur organ deal multipl organ involv respons potenti therapeut target emot energi metabol disord under psychiatr disord

D012686;D006943

T033;T023;T047

obes enhanc antivir immun genit mucosa microbiota mediat effect cell obes detriment immun system impair lymphat cell develop lymphopoiesi induc dysfunct antitumor immun also promot tumor progress howev direct evid impact obes viral infect lack report protect role obes herp simplex virus infect genit mucosa mice although convent antivir immun compar obes mice lean mice obes enhanc cytotox subset cell effect mediat l arginin produc commens microbiota genit mucosa induc pseudonormoxia cell result increas natur killer nk group nkgd express cell downregul hypoxia induc factor alpha hifa induc nitric oxid product therebi protect mice lethal genit herp thus work illumin one mechan obes induc composit chang vagin microbiota affect mucos immun respons viral infect

D018258;D064307

T001;T005;T032;T028

platelet p mediat platelet leukocyt interact curtail bacteri dissemin pneumococc pneumonia phosphatidylinositol kinas catalyt subunit p involv tumorigenesi hemostasi howev remain unclear p also regul platelet mediat immun respons could import consequ immun modul anti cancer treatment p inhibitor thus investig platelet p affect inflamm infect use mous model streptococcus pneumonia induc pneumonia find platelet specif p defici pharmacolog inhibit p tgx exacerb diseas pathogenesi prevent platelet monocyt neutrophil interact diminish infiltr enhanc bacteri dissemin platelet p mediat neutrophil phagocytosi pneumonia vitro curtail bacteremia vivo genet defici inhibit platelet p also impair macrophag recruit independ model steril periton result demonstr platelet p dysfunct exacerb pulmonari infect imped leukocyt function therebi find provid import insight immunomodulatori potenti pik inhibitor bacteri infect

D011018

T047

epitop enrich immunogen expand respons conserv viral site pathogen evad host humor respons accumul mutat surfac antigen variabl conserv region mutat without compromis fit antibodi target conserv epitop often broad protect remain minor compon repertoir ration immunogen design leverag structur understand viral antigen modul humor respons favor respons report epitop enrich immunogen present higher copi number influenza hemagglutinin ha receptor bind site rbs epitop relat b cell epitop immun partial human murin model imprint h influenza show h specif serum h specif b cell rbs direct singl b cell analys show genet restrict respons structur analysi defin rbs direct antibodi engag rbs germlin encod contact data show epitop enrich expand b cell respons toward conserv epitop advanc immunogen design approach next generat viral vaccin

D007251;D007252

T129;T047;T121;T109

chromosom encod tss independ contribut horizont gene transfer enterococcus faecali bacteri type iv secret system tsss specif devic mediat dissemin antibiot resist gene via horizont gene transfer hgt multi drug resist enterococcus faecali e faecali repres clinic public health threat transfer plasmid function plasmid encod pe tss report chromosom encod ce tss exist e faecali isol compar pe tss ce tss display distinct characterist protein architectur capabl mediat larg genom wide gene transfer imprecis manner reciproc exchang ce tss pe tss associ origin transfer orit could disrupt hgt function indic ce tss independ system compar pe tss taken togeth ce tss shed light knowledg hgt gram posit bacteria trigger us explor evolutionari mechan e faecali

D013293;D022761

T045;T007

loss neuron tet enhanc hippocamp depend cognit function dna methyl emerg critic modul neuron plastic cognit function notwithstand role enzym demethyl dna remain fulli explor report loss ten eleven transloc methylcytosin dioxygenas tet catalyz oxid methylcytosin mc hydroxymethylcytosin hmc adult neuron enhanc cognit function adult mous hippocampus detect enrich tet neuron viral mediat neuron overexpress rna interfer tet alter dendrit complex synapt plastic relat gene express vitro overexpress neuron tet adult hippocampus loss tet adult glutamaterg neuron result differenti hydroxymethyl associ gene involv synapt transmiss function overexpress neuron tet impair hippocamp depend memori loss neuron tet enhanc memori ultim data identifi neuron tet molecular target boost cognit function

D011518;D049308

T123;T126;T116

curat islet hematopoiet cell transplant diabet mice without toxic bone marrow condit mix hematopoiet chimer promot immun toler donor match transplant tissu like pancreat islet howev adopt strategi limit toxic standard treatment enabl donor hematopoiet cell engraft address concern non myeloabl condit regimen enabl hematopoiet chimer allograft toler across fulli mismatch major histocompat complex mhc barrier treatment cd antibodi target c kit administ cell deplet antibodi low dose radiat permit durabl multi lineag chimer immunocompet mice follow hematopoiet cell transplant diabet mice co transplant donor match islet hematopoiet cell durabl correct diabet without chronic immunosuppress appreci evid graft versus host diseas gvhd donor deriv thymic antigen present cell host deriv peripher regulatori cell like mediat allotoler find provid foundat safer bone marrow condit cell transplant regimen establish hematopoiet chimer islet allograft toler

D018380;D003921;D006086

T061;T047;T050

sex differ resili ferroptosi underli sexual dimorph kidney injuri repair human mice repair acut kidney injuri wors male femal provid evid sexual dimorph result sex differ ferroptosi iron depend lipid peroxid driven regul cell death use genet singl cell transcriptom approach mice report femal sex confer strike protect ferroptosi experiment induc proxim tubular pt cell delet glutathion peroxidas gpx singl cell transcriptom analys identifi nfe relat factor nrf antioxid protect pathway femal resili mechan ferroptosi genet inhibit pharmacolog activ studi show nrf control pt cell fate plastic regul ferroptosi import pharmacolog nrf activ protect male pt cell ferroptosi improv cellular plastic femal data highlight nrf potenti therapeut target prevent fail renal repair acut kidney injuri sex modul cellular plastic

D000079403;D058186

T047;T037;T043

tuft cell intrins extrins mediat norovirus tropism regul viral immun murin norovirus mnov model human norovirus interrog mechan viral tropism persist previous demonstr persist strain mnov cr infect tuft cell dispens non persist strain mnov cw show divers mnov strain requir tuft cell chronic enter infect also demonstr interferon ifn act direct tuft cell cure chronic mnov cr infect type iii ifn signal togeth via stat tuft cell restrict mnov cw tropism develop enteroid model find mnov cr mnov cw similar infect tuft cell equal ifn suscept suggest ifn deriv non epitheli cell signal tuft cell tran restrict mnov cw tropism thus tuft cell tropism enabl mnov persist determin tuft cell intrins factor viral receptor express extrins factor immunomodulatori signal non epitheli cell

D029322;D017250

T005;T047

nucleoporin facilit orc load onto chromatin origin recognit complex orc bind throughout genom initi dna replic metazoan still unclear orc target specif loci facilit helicas load replic initi perform immunoprecipit coupl mass spectrometri orc drosophila embryo surpris find orc associ multipl subunit nup subcomplex nuclear pore bioinformat analysi reveal relat modencod factor nucleoporin among enrich factor orc bind site critic deplet nucleoporin eli member nup complex decreas orc load onto chromatin deplet eli also sensit cell replic fork stall could reflect defect establish dormant replic origin work reveal connect orc replic initi nucleoporin suggest function nucleoporin metazoan replic initi

D020346;D029721

T123;T116

oxaliplatin disrupt nucleolar function biophys disintegr platinum pt compound oxaliplatin among common prescrib anti cancer drug despit consider clinic impact molecular basi platinum cytotox cancer specif remain unclear show oxaliplatin backbon treatment colorect cancer caus liquid liquid demix nucleoli clinic relev concentr data suggest biophys defect lead cell cycl arrest shutdown pol mediat transcript ultim cell death propos instead target singl molecul oxaliplatin preferenti partit nucleoli modifi nucleolar rna protein mechan provid general approach drug increas number cellular process link biomolecular condens

D010984;D000970

T121;T196;T109

intertwin wdr ntd dimer recogn basic helic motif camsap protein proper central pair microtubul format calmodulin regul spectrin associ protein camsap bind n termin domain wd repeat wdr ntd featur lish ctlh motif proper generat axonem central pair microtubul cp mts planar beat pattern mammalian motil multicilia under molecular mechan howev remain unclear determin structur apo wdr ntd wdr ntd complex characterist wdr bind region wbr camsap wdr ntd form intertwin dimer special cross region cor addit canon lish globular helic core gac basic wbr peptid adopt helic conform anchor tailor acid pocket embed cor mutat target bind pocket disrupt interact wdr ntd camsap impair wdr camsap interact mark reduc rescu effect wdr cp mts ciliari beat wdr defici ependym cell thus wdr ntd function recogn specif basic helic motif camsap protein via non canon cor target bind site lish ctlh contain domain

D008870;D002923

T026

identif character nfatc skelet stem cell bone regener skelet stem cell sscs fuel adult bone stem resourc maintain homeostasi support regener depend precis determin osteogen lineag commit sscs studi use cre loxp report lineag track identifi character popul nfatc sscs bone regener pre exist nfatc sscs involv earli bone callus format subsequ nfatc sscs produc osteolineag descend subsequ stage regener ca trigger transcript activ nfatc constitut pre imprint memori trajectori intrins orchestr osteogenesi sscs inhibit ca nfatc signal sscs direct impair osteogenesi bone regener summari find provid mechanist understand adult bone regener regul nfatc sscs

D001861;D013234

T081;T025;T042

neil contribut fanconi anemiabrca pathway promot downstream doubl strand break repair step interstrand crosslink icl repair canon fanconi anemia fa pathway generat doubl strand break dsbs subsequ repair homolog recombin hr pathway recent studi show neil dna glycosylas repair psoralen icl direct unhook howev whether neil regul mmc cisplatin icl repair remain unclear show neil particip dsb repair step icl repair promot hr pathway mechanist neil recruit dsb site grf zinc finger motif neil interact dsb resect machineri includ ctip mre rad nbs mrn complex dna mediat grf zinc finger motif addit neil necessari chromatin recruit resect machineri deplet neil decreas end resect compromis hr taken togeth result show neil play import role mmccisplatin icl repair promot hr step fabrca pathway

D005199

T047

apoa mimet peptid enhanc remyelin promot clearanc degrad myelin debri progress natur demyelin diseas lie inabl central nervous system cns induc proper remyelin recent other demonstr dysregul innat immun respons partial under failur cns remyelin extens accumul myelin deriv lipid inabl process lipid found induc diseas promot phagocyt phenotyp henc restor abil phagocyt metabol efflux myelin deriv lipid repres promis strategi promot remyelin show apoa mimet peptid molecul well known promot activ lipid efflux transport abca mark enhanc remyelin mechanist find repair induc properti attribut increas clearanc metabol remyelin inhibit myelin debri via fatti acid translocas protein cd transcript control abca jak stat signal pathway altogeth find indic promot remyelin stimul clearanc degrad myelin debri

D000074586;D003711

T047;T046;T043

systemat discoveri function dissect enhanc need cancer cell fit prolifer scarciti function valid enhanc human genom present signific hurdl understand cis regulatori element contribut human diseas carri high multiplex crispr base perturb sequenc identifi enhanc requir cell prolifer fit human cancer cell line result suggest cell fit enhanc unlik target gene display high cell type specif chromatin featur typic adopt modular structur compris activ element enrich motif oncogen transcript factor surround repress element enrich motif recogn transcript factor tumor suppressor function identifi cell fit enhanc select access clinic tumor sampl level chromatin access associ patient surviv result reveal function enhanc across multipl cancer cell line character context depend chromatin organ yield insight alter transcript program cancer cell

D004742;D009369

T123;T191;T114

tune landscap ventral stream goal visual neurosci explain neuron respond natur scene howev neuron general test use simpler stimuli often transform smooth allow measur tune function ie respons peak slope test idea classic tune curv view slice higher dimension tune landscap use activ maxim stimuli prototyp landmark generat imag space map tune function around peak find neuron show smooth bell shape tune consist radial basi function span vast imag transform rang systemat differ landscap geometri v inferotempor cortex model trend infer neuron higher visual cortex higher intrins featur dimension overal result suggest visual neuron better view signal distanc prototyp imag manifold

D014793

T023;T029

memori b cell respons influenza vaccin impair older person influenza infect impart age relat increas mortal morbid effect countermeasur vaccin howev vaccin offer modest protect older adult investig age impact memori b cell respons track hemagglutinin specif b cell index flow sort singl cell rna sequenc scrna seq healthi adult administ trival influenza vaccin demonstr age relat skew memori b cell compart week vaccin younger adult develop hemagglutinin specif memori b cell fcrl atyp phenotyp show evid somat hypermut posit select happen lesser extent older person use public avail scrna seq pair human lymph node blood sampl corrobor fcrl atyp memori b cell deriv germin center gc precursor togeth studi show age human gc reaction memori b cell respons follow vaccin defect

D007251;D007252

T129;T047;T121;T109

hiv vpu restrict fc mediat effector function vivo non neutral antibodi nnab elimin hiv infect cell via antibodi depend cellular cytotox adcc identifi correl protect rv vaccin trial fc mediat effector function nnab recent shown alter cours hiv infect vivo use vpu defect virus sinc vpu known downregul cell surfac cd trigger conform chang viral envelop glycoprotein env ask whether lack vpu express link observ nnab activ find restor vpu express great reduc nnab recognit infect cell render resist adcc moreov administr nnab human mice reduc viral load anim infect vpu defect wild type virus cd mimet administr known open env expos nnab epitop render wild type virus sensit nnab fc effector function work highlight import vpu mediat evas humor respons

D015497;D015658;D006679

T005;T034;T047

identif hematopoiet stem cell resid mening adult mice steadi state steadi state extramedullari hematopoiesi adulthood emerg field great interest mening contain innat adapt immun cell provid immunosurveil central nervous system cns hematopoiet progenitor give rise mening immun cell remain elus report steadi state mening adult mice host hematopoiet stem cell hscs defin long term effici multi lineag reconstitut self renew capac mening blood spleen bone marrow subleth irradi adult recipi hscs lodg mening birth local express pro hematopoiet nich factor mening hscs local maintain homeostasi get replenish blood resid pool reduc tissu specif express profil mening hscs provid cns constant suppli leukocyt adapt local microenviron

D006412;D006410

T025;T042

pan claudin famili interactom analysi reveal share specif interact claudin famili transmembran protein express epitheli tissu major compon tight junction tjs defin barrier properti epithelia maintain cell polar claudin regul format tjs function exert outsid entir understood although long unstructur c termin tail essenti regul unclear involv function beyond interact tj associ protein tj protein zo tjp present interactom studi pan claudin famili madin darbi canin kidney mdck c cell combin two complementari mass spectrometri base pull techniqu creat interact landscap entir claudin famili interact partner claudin c termini reveal possibl implic local biolog process epitheli cell regul post translat modif ptms

D057167;D019108

T123;T116;T030

anterior posterior gradient integr process forelimb movement direct distanc macaqu pariet cortex major issu modern neurosci understand cell popul present multipl spatial motor featur goal direct movement direct distanc depth arm movement often appear control independ behavior unknown whether share neural resourc use inform theori singular valu decomposit dimension reduct method compar direct depth effect converg across three pariet area arm movement task method show stronger direct effect earli movement prepar wherea depth signal prevail movement execut go anterior posterior sector report increas number cell process signal stronger depth effect find suggest serial direct depth process consist behavior evid reveal gradient joint versus independ control featur pariet cortex support role sensorimotor transform

D011597;D008251

T015;T041

toll like receptor orchestr tumor suppressor respons non small cell lung cancer target earli stage lung cancer vital improv surviv howev mechan compon earli tumor suppressor respons lung cancer well understood report studi role toll like receptor tlr regul oncogen induc senesc key tumor suppressor respons premalign use human lung cancer sampl genet engin mous model show tlr activ earli lung tumorigenesi correl improv surviv clinic regress mechanist tlr impair earli lung cancer progress via activ cell intrins cell cycl arrest pathway proinflammatori senesc associ secretori phenotyp sasp sasp regul non cell autonom anti tumor respons immun surveil premalign cell observ impair myeloid cell recruit lung tumor tlr loss last show administr tlr agonist reduc lung tumor growth highlight tlr possibl therapeut target

D002289;D008175

T191

complementari hemispher later languag social process human brain human uniqu abil use languag social communic neural architectur languag comprehens product may promin emerg brain area origin involv social cognit direct test fundament link languag social process use function magnet reson data mri data human subject cortic activ languag social task show strike similar complementari hemispher later within core languag area left later activ languag task mirror right later activ social task outsid area activ left later task perhap indic multimod integr social semant inform find could import implic understand neurocognit mechan social disord autism

D007802;D001921

T171;T023

singl cell transcriptom analysi vivo respons viral infect cave nectar bat eonycteri spelaea bat reservoir host mani zoonot virus pandem potenti util singl cell transcriptom sequenc scrna seq analyz immun respons bat lung upon vivo infect doubl strand rna virus pteropin orthoreovirus prvm bat neutrophil distinguish high basal ido express nk cell cell abund immun cell lung tissu three distinct cd effector cell popul could delin differenti express klrb gfra dpp select nk cluster increas express gene involv cell activ effector function earli viral infect alveolar macrophag classic monocyt drove antivir interferon signal infect expand csfr popul express collagen like gene becam predomin myeloid cell type post infect work uncov featur relev viral diseas toler bat lay foundat futur experiment work serv resourc compar immunolog studi

D002685;D014777

T047;T015

expans memori stem cell superior anti tumor immun urolithin induc mitophagi memori stem cell scm display increas self renew prolong surviv capabl thus prevent cell exhaust promot effect anti tumor cell respons scm cell expand urolithin ua produc commens gut microbiom food rich ellagitannin known improv mitochondri health oral ua administr tumor bear mice confer strong anti tumor cd cell immun wherea ex vivo ua pre treat cell display improv anti tumor function upon adopt cell transfer ua induc scm format depend pink mediat mitophagi trigger cytosol releas mitochondri phosphatas pgam cytosol pgam dephosphoryl catenin drove wnt signal compensatori mitochondri biogenesi collect unravel critic signal pathway link mitophagi scm format suggest well toler metabol compound ua repres attract option improv immun therapi

D063306;D003374

T121;T109;T043

innat immun mechan mrna vaccin lipid nanoparticl lnp encapsul nucleosid modifi mrna platform use generat safe effect vaccin record time covid review current understand manner wherebi mrna vaccin induc innat immun activ contribut protect immun discuss innat immun sens mrna vaccin cellular intracellular level consid contribut mrna lnp compon immunogen key messag emerg recent observ lnp carrier act power adjuv novel vaccin platform context highlight import gap understand discuss new insight mechan under effect mrna lnp vaccin may enabl tailor mrna carrier molecul develop vaccin greater effect milder advers event futur

D000086382

T047;T067

regulatori cell metabol sensor compel experiment evid link immun metabol perspect propos forkhead box p foxp cd cd regulatori treg cell key metabol sensor control immunolog state respons intrins capac perceiv nutrit chang treg cell high anabol state vivo resid metabol crucial district recircul lymphoid non lymphoid site enabl recogn metabol cue adapt intracellular metabol anti inflammatori function paracrin system level privileg regul interfac neuroendocrin immun system role treg cell maintain metabol homeostasi make cell promis target therapeut strategi aim restor organism homeostasi autoimmun also metabol disord

D050378;D051858

T123;T116;T025

embarrass rich rort antigen present cell peripher toler rort regulatori treg cell critic toward maintain gut immun toler recent studi publish natur kedmi et al lyu et al akagbosu et al describ mhcii rort antigen present cell mediat rort treg cell differenti propos dispar ident cell

D057132;D061166

T116;T042;T192

lay foundat singl cell studi bat bat serv host virus caus diseas human issu immun gamag et al character immun cell repertoir eonycteri spelaea bat lung tissu use singl cell transcriptom provid insight vivo immun respons infect pteropin orthoreovirus prvm establish paradigm futur compar immunolog studi

D002685;D014780

T005;T015

upper airway brain protect plasma cell local affair protect upper airway brain viral invas olfactori mucosa critic wellford et al describ barrier restrict passag circul antibodi prevent reach olfactori mucosa instead plasma cell recruit site prevent viral infect airway brain local antibodi product

D010950;D012137

T022;T023;T025

bam pathogen control brain border border associ macrophag bam resid interfac brain peripheri includ mening choroid plexus issu immun two studi report dynam divers fate murin bam infect assign cell neuroprotect role

D008578;D008264

T023;T025

interferon syndrom less individu syndrom ds lower risk viral infect general popul yet infecti episod often serious issu immun mall et al provid import mechanist insight paradox show individu ds dysregul ifn respons increas initi signal translat refractori state make immun system less capabl control viral infect

D004314;D014777

T047