{'id': 'HP_0002277', 'url': 'http://purl.obolibrary.org/obo/HP_0002277', 'lbl': 'Horner syndrome', 'desc': "label: Horner syndrome\ndefinition : An abnormality resulting from a lesion of the sympathetic nervous system characterized by a combination of unilateral ptosis, miosis, and often ipsilateral hypohidrosis and conjunctival injection.\nsynonyms :Horner's syndrome; Oculosympathetic palsy\n"}


{'id': 'HP_0002280', 'url': 'http://purl.obolibrary.org/obo/HP_0002280', 'lbl': 'Enlarged cisterna magna', 'desc': 'label: Enlarged cisterna magna\ndefinition : Increase in size of the cisterna magna, one of three principal openings in the subarachnoid space between the arachnoid and pia mater, located between the cerebellum and the dorsal surface of the medulla oblongata.\nsynonyms :Large cisterna magna; Mega cisterna magna\n'}


{'id': 'HP_0002281', 'url': 'http://purl.obolibrary.org/obo/HP_0002281', 'lbl': 'obsolete Gray matter heterotopias', 'desc': 'label: obsolete Gray matter heterotopias\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002282', 'url': 'http://purl.obolibrary.org/obo/HP_0002282', 'lbl': 'Gray matter heterotopia', 'desc': 'label: Gray matter heterotopia\ndefinition : Heterotopia or neuronal heterotopia are macroscopic clusters of misplaced neurons (gray matter), most often situated along the ventricular walls or within the subcortical white matter.\nsynonyms :Gray matter heterotopias; Grey matter heterotopia; Grey matter heterotopias; Heterotopia; Heterotopias; Neuronal heterotopia\n'}


{'id': 'HP_0002283', 'url': 'http://purl.obolibrary.org/obo/HP_0002283', 'lbl': 'Global brain atrophy', 'desc': 'label: Global brain atrophy\ndefinition : Unlocalized atrophy of the brain with decreased total brain matter volume and increased ventricular size.\nsynonyms :Diffuse brain atrophy; Generalised brain atrophy; Generalised brain degeneration; Generalised cerebral atrophy; Generalized brain atrophy; Generalized brain degeneration; Generalized cerebral atrophy\n'}


{'id': 'HP_0002286', 'url': 'http://purl.obolibrary.org/obo/HP_0002286', 'lbl': 'Fair hair', 'desc': 'label: Fair hair\ndefinition : A lesser degree of hair pigmentation than would otherwise be expected.\nsynonyms :Blond hair; Fair hair; Fair hair color; Fair hair colour; Flaxen hair color; Flaxen hair colour; Light colored hair; Light coloured hair; Sandy hair color; Sandy hair colour; Straw colored hair; Straw coloured hair; Towhead (hair color)\n'}


{'id': 'HP_0002287', 'url': 'http://purl.obolibrary.org/obo/HP_0002287', 'lbl': 'Progressive alopecia', 'desc': 'label: Progressive alopecia\ndefinition : Progressive loss of hair.\nsynonyms :\n'}


{'id': 'HP_0002289', 'url': 'http://purl.obolibrary.org/obo/HP_0002289', 'lbl': 'Alopecia universalis', 'desc': 'label: Alopecia universalis\ndefinition : Loss of all hair on the entire body.\nsynonyms :Alopecia, complete; Universal alopecia\n'}


{'id': 'HP_0002290', 'url': 'http://purl.obolibrary.org/obo/HP_0002290', 'lbl': 'Poliosis', 'desc': 'label: Poliosis\ndefinition : Circumscribed depigmentation of the hair of the head or the eyelashes.\nsynonyms :Patch of white hair; White patch\n'}


{'id': 'HP_0002292', 'url': 'http://purl.obolibrary.org/obo/HP_0002292', 'lbl': 'Frontal balding', 'desc': 'label: Frontal balding\ndefinition : Absence of hair in the anterior midline and/or parietal areas.\nsynonyms :Male pattern baldness; Frontal balding\n'}


{'id': 'HP_0002293', 'url': 'http://purl.obolibrary.org/obo/HP_0002293', 'lbl': 'Alopecia of scalp', 'desc': 'label: Alopecia of scalp\ndefinition : \nsynonyms :Absence of scalp hair; Baldness; Missing scalp hair; Pathologic hair loss from scalp; Scalp hair loss\n'}


{'id': 'HP_0002296', 'url': 'http://purl.obolibrary.org/obo/HP_0002296', 'lbl': 'Progressive hypotrichosis', 'desc': 'label: Progressive hypotrichosis\ndefinition : Progressively reduced or lacking hair growth.\nsynonyms :\n'}


{'id': 'HP_0002297', 'url': 'http://purl.obolibrary.org/obo/HP_0002297', 'lbl': 'Red hair', 'desc': 'label: Red hair\ndefinition : \nsynonyms :Ginger hair color; Ginger hair colour; Red hair; Red hair color; Red hair colour; Red head (hair color)\n'}


{'id': 'HP_0002298', 'url': 'http://purl.obolibrary.org/obo/HP_0002298', 'lbl': 'Absent hair', 'desc': 'label: Absent hair\ndefinition : \nsynonyms :Absent hair\n'}


{'id': 'HP_0002299', 'url': 'http://purl.obolibrary.org/obo/HP_0002299', 'lbl': 'Brittle hair', 'desc': 'label: Brittle hair\ndefinition : Fragile, easily breakable hair, i.e., with reduced tensile strength.\nsynonyms :Easily breakable hair; Fractured hair; Fragile hair; Reduced tensile strength of hair; Brittle hair\n'}


{'id': 'HP_0002300', 'url': 'http://purl.obolibrary.org/obo/HP_0002300', 'lbl': 'Mutism', 'desc': 'label: Mutism\ndefinition : \nsynonyms :Inability to speak; Muteness\n'}


{'id': 'HP_0002301', 'url': 'http://purl.obolibrary.org/obo/HP_0002301', 'lbl': 'Hemiplegia', 'desc': 'label: Hemiplegia\ndefinition : Paralysis (complete loss of muscle function) in the arm, leg, and in some cases the face on one side of the body.\nsynonyms :Paralysis on one side of body\n'}


{'id': 'HP_0002304', 'url': 'http://purl.obolibrary.org/obo/HP_0002304', 'lbl': 'Akinesia', 'desc': 'label: Akinesia\ndefinition : Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily.\nsynonyms :\n'}


{'id': 'HP_0002305', 'url': 'http://purl.obolibrary.org/obo/HP_0002305', 'lbl': 'Athetosis', 'desc': 'label: Athetosis\ndefinition : A slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Athetosis involves continuous smooth movements that appear random and are not composed of recognizable sub-movements or movement fragments. In contrast to chorea, in athetosis, the same regions of the body are repeatedly involved. Athetosis may worsen with attempts at movement of posture, but athetosis can also occur at rest.\nsynonyms :Athetoid movements; Involuntary writhing movements; Involuntary writhing movements in fingers, hands, toes, and feet\n'}


{'id': 'HP_0002307', 'url': 'http://purl.obolibrary.org/obo/HP_0002307', 'lbl': 'Drooling', 'desc': 'label: Drooling\ndefinition : Habitual flow of saliva out of the mouth.\nsynonyms :Dribbling; Drooling; Sialorrhea\n'}


{'id': 'HP_0002308', 'url': 'http://purl.obolibrary.org/obo/HP_0002308', 'lbl': 'Chiari malformation', 'desc': 'label: Chiari malformation\ndefinition : Chiari malformation consists of a downward displacement of the cerebellar tonsils and the medulla through the foramen magnum, sometimes causing hydrocephalus as a result of obstruction of CSF outflow.\nsynonyms :Arnold-Chiari malformation\n'}


{'id': 'HP_0002310', 'url': 'http://purl.obolibrary.org/obo/HP_0002310', 'lbl': 'Orofacial dyskinesia', 'desc': 'label: Orofacial dyskinesia\ndefinition : \nsynonyms :Orofacial dyskinesias\n'}


{'id': 'HP_0002311', 'url': 'http://purl.obolibrary.org/obo/HP_0002311', 'lbl': 'Incoordination', 'desc': 'label: Incoordination\ndefinition : \nsynonyms :Difficulties in coordination; Incoordination; Incoordination of limb movements; Limb incoordination\n'}


{'id': 'HP_0002312', 'url': 'http://purl.obolibrary.org/obo/HP_0002312', 'lbl': 'Clumsiness', 'desc': 'label: Clumsiness\ndefinition : Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects.\nsynonyms :Clumsiness\n'}


{'id': 'HP_0002313', 'url': 'http://purl.obolibrary.org/obo/HP_0002313', 'lbl': 'Spastic paraparesis', 'desc': 'label: Spastic paraparesis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002314', 'url': 'http://purl.obolibrary.org/obo/HP_0002314', 'lbl': 'Degeneration of the lateral corticospinal tracts', 'desc': 'label: Degeneration of the lateral corticospinal tracts\ndefinition : Deterioration of the tissues of the lateral corticospinal tracts.\nsynonyms :Degeneration of lateral corticospinal tracts\n'}


{'id': 'HP_0002315', 'url': 'http://purl.obolibrary.org/obo/HP_0002315', 'lbl': 'Headache', 'desc': 'label: Headache\ndefinition : Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.\nsynonyms :Headache; Headaches\n'}


{'id': 'HP_0002317', 'url': 'http://purl.obolibrary.org/obo/HP_0002317', 'lbl': 'Unsteady gait', 'desc': 'label: Unsteady gait\ndefinition : \nsynonyms :Gait instability; Unsteady walk\n'}


{'id': 'HP_0002318', 'url': 'http://purl.obolibrary.org/obo/HP_0002318', 'lbl': 'Cervical myelopathy', 'desc': 'label: Cervical myelopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002321', 'url': 'http://purl.obolibrary.org/obo/HP_0002321', 'lbl': 'Vertigo', 'desc': 'label: Vertigo\ndefinition : An abnormal sensation of spinning while the body is actually stationary.\nsynonyms :Dizzy spell; Dizziness\n'}


{'id': 'HP_0002322', 'url': 'http://purl.obolibrary.org/obo/HP_0002322', 'lbl': 'Resting tremor', 'desc': 'label: Resting tremor\ndefinition : A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.\nsynonyms :Rest tremor; Resting tremor; Tremor at rest; Parkinsonian tremor\n'}


{'id': 'HP_0002323', 'url': 'http://purl.obolibrary.org/obo/HP_0002323', 'lbl': 'Anencephaly', 'desc': "label: Anencephaly\ndefinition : Anencephaly is a developmental anomaly characterized by a fetus that has no calvarium, with a lack of most or all of the fetus' brain tissue. Anencephaly belongs to a collective group known as neural tube defects (NTD) and is a result of the neural tube failing to close in its rostral end during fetal development.\nsynonyms :Embryonic anencephaly; Fetal anencephaly; Foetal anencephaly\n"}


{'id': 'HP_0002324', 'url': 'http://purl.obolibrary.org/obo/HP_0002324', 'lbl': 'Hydranencephaly', 'desc': 'label: Hydranencephaly\ndefinition : A defect of development of the brain characterized by replacement of greater portions of the cerebral hemispheres and the corpus striatum by cerebrospinal fluid (CSF) and glial tissue.\nsynonyms :Hydrancephaly\n'}


{'id': 'HP_0002326', 'url': 'http://purl.obolibrary.org/obo/HP_0002326', 'lbl': 'Transient ischemic attack', 'desc': 'label: Transient ischemic attack\ndefinition : \nsynonyms :Mini stroke; TIA; Transient ischaemic attack; Transient ischaemic attacks; Transient ischemic attacks\n'}


{'id': 'HP_0002329', 'url': 'http://purl.obolibrary.org/obo/HP_0002329', 'lbl': 'Drowsiness', 'desc': 'label: Drowsiness\ndefinition : Excessive daytime sleepiness.\nsynonyms :Drowsiness; Sleepy\n'}


{'id': 'HP_0002330', 'url': 'http://purl.obolibrary.org/obo/HP_0002330', 'lbl': 'Paroxysmal drowsiness', 'desc': 'label: Paroxysmal drowsiness\ndefinition : Attacks of disabling daytime drowsiness and low alertness.\nsynonyms :\n'}


{'id': 'HP_0002331', 'url': 'http://purl.obolibrary.org/obo/HP_0002331', 'lbl': 'Recurrent paroxysmal headache', 'desc': 'label: Recurrent paroxysmal headache\ndefinition : Repeated episodes of headache with rapid onset, reaching a peak within minutes and of short duration (less than one hour) with pain that is throbbing, pulsating, or bursting in quality.\nsynonyms :\n'}


{'id': 'HP_0002332', 'url': 'http://purl.obolibrary.org/obo/HP_0002332', 'lbl': 'Lack of peer relationships', 'desc': 'label: Lack of peer relationships\ndefinition : The state of not having relationships with peers. This may be caused by behavioral or physical barriers.\nsynonyms :\n'}


{'id': 'HP_0002333', 'url': 'http://purl.obolibrary.org/obo/HP_0002333', 'lbl': 'Motor deterioration', 'desc': 'label: Motor deterioration\ndefinition : Loss of previously present motor (i.e., movement) abilities.\nsynonyms :Progressive degeneration of movement\n'}


{'id': 'HP_0002334', 'url': 'http://purl.obolibrary.org/obo/HP_0002334', 'lbl': 'Abnormal cerebellar vermis morphology', 'desc': 'label: Abnormal cerebellar vermis morphology\ndefinition : An anomaly of the vermis of cerebellum.\nsynonyms :Abnormality of the cerebellar vermis\n'}


{'id': 'HP_0002335', 'url': 'http://purl.obolibrary.org/obo/HP_0002335', 'lbl': 'Agenesis of cerebellar vermis', 'desc': 'label: Agenesis of cerebellar vermis\ndefinition : Congenital absence of the vermis of cerebellum.\nsynonyms :Cerebellar vermis aplasia; Vermian agenesis\n'}


{'id': 'HP_0002339', 'url': 'http://purl.obolibrary.org/obo/HP_0002339', 'lbl': 'Abnormal caudate nucleus morphology', 'desc': 'label: Abnormal caudate nucleus morphology\ndefinition : Any structural abnormality of the caudate nucleus.\nsynonyms :Abnormality of the caudate nucleus\n'}


{'id': 'HP_0002340', 'url': 'http://purl.obolibrary.org/obo/HP_0002340', 'lbl': 'Caudate atrophy', 'desc': 'label: Caudate atrophy\ndefinition : \nsynonyms :Caudate degeneration\n'}


{'id': 'HP_0002341', 'url': 'http://purl.obolibrary.org/obo/HP_0002341', 'lbl': 'Cervical cord compression', 'desc': 'label: Cervical cord compression\ndefinition : Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness.\nsynonyms :Cervical cord compression myelopathy\n'}


{'id': 'HP_0002342', 'url': 'http://purl.obolibrary.org/obo/HP_0002342', 'lbl': 'Intellectual disability, moderate', 'desc': 'label: Intellectual disability, moderate\ndefinition : Moderate mental retardation is defined as an intelligence quotient (IQ) in the range of 35-49.\nsynonyms :IQ between 34 and 49; Mental retardation, moderate; Moderate mental deficiency; Moderate mental retardation\n'}


{'id': 'HP_0002343', 'url': 'http://purl.obolibrary.org/obo/HP_0002343', 'lbl': 'Normal pressure hydrocephalus', 'desc': 'label: Normal pressure hydrocephalus\ndefinition : A form of hydrocephalus characterized by enlarged cerebral ventricles and normal cerebrospinal fluid (CSF) pressure upon lumbar puncture.\nsynonyms :Normal-pressure hydrocephalus\n'}


{'id': 'HP_0002344', 'url': 'http://purl.obolibrary.org/obo/HP_0002344', 'lbl': 'Progressive neurologic deterioration', 'desc': 'label: Progressive neurologic deterioration\ndefinition : \nsynonyms :Neurologic deterioration; Neurologic deterioration, progressive; Progressive mental deterioration; Progressive neurodegeneration; Worsening neurological symptoms\n'}


{'id': 'HP_0002345', 'url': 'http://purl.obolibrary.org/obo/HP_0002345', 'lbl': 'Action tremor', 'desc': 'label: Action tremor\ndefinition : A tremor present when the limbs are active, either when outstretched in a certain position or throughout a voluntary movement.\nsynonyms :Ataxic tremor\n'}


{'id': 'HP_0002346', 'url': 'http://purl.obolibrary.org/obo/HP_0002346', 'lbl': 'Head tremor', 'desc': 'label: Head tremor\ndefinition : An unintentional, oscillating to-and-fro muscle movement affecting head movement.\nsynonyms :Head tremor\n'}


{'id': 'HP_0002349', 'url': 'http://purl.obolibrary.org/obo/HP_0002349', 'lbl': 'Focal aware seizure', 'desc': 'label: Focal aware seizure\ndefinition : A type of focal-onset seizure in which awareness is preserved. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile.\nsynonyms :Focal aware seizures; Focal seizure with retained awareness; Focal seizure without impairment of awareness; Focal seizure without impairment of consciousness or awareness; Focal seizures without impairment of consciousness or awareness; Partial seizure with retained awareness; Partial seizure without impairment of awareness; Simple partial seizure; Simple partial seizures\n'}


{'id': 'HP_0002350', 'url': 'http://purl.obolibrary.org/obo/HP_0002350', 'lbl': 'Cerebellar cyst', 'desc': 'label: Cerebellar cyst\ndefinition : \nsynonyms :Cerebellar cysts\n'}


{'id': 'HP_0002352', 'url': 'http://purl.obolibrary.org/obo/HP_0002352', 'lbl': 'Leukoencephalopathy', 'desc': 'label: Leukoencephalopathy\ndefinition : This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells.\nsynonyms :\n'}


{'id': 'HP_0002353', 'url': 'http://purl.obolibrary.org/obo/HP_0002353', 'lbl': 'EEG abnormality', 'desc': "label: EEG abnormality\ndefinition : Abnormality observed by electroencephalogram (EEG), which is used to record of the brain's spontaneous electrical activity from multiple electrodes placed on the scalp.\nsynonyms :Abnormal EEG; Abnormal electroencephalogram; EEG abnormalities; Electroencephalogram abnormal; Electroencephalogram abnormalities\n"}


{'id': 'HP_0002354', 'url': 'http://purl.obolibrary.org/obo/HP_0002354', 'lbl': 'Memory impairment', 'desc': 'label: Memory impairment\ndefinition : An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness.\nsynonyms :Forgetfulness; Memory impairment; Memory loss; Memory problems; Poor memory\n'}


{'id': 'HP_0002355', 'url': 'http://purl.obolibrary.org/obo/HP_0002355', 'lbl': 'Difficulty walking', 'desc': 'label: Difficulty walking\ndefinition : Reduced ability to walk (ambulate).\nsynonyms :Difficulty in walking; Difficulty walking; Walking disability\n'}


{'id': 'HP_0002356', 'url': 'http://purl.obolibrary.org/obo/HP_0002356', 'lbl': "Writer's cramp", 'desc': "label: Writer's cramp\ndefinition : A focal dystonia of the fingers, hand, and/or forearm that appears when the affected person attempts to do a task that requires fine motor movements such as writing or playing a musical instrument.\nsynonyms :Writer's cramp\n"}


{'id': 'HP_0002357', 'url': 'http://purl.obolibrary.org/obo/HP_0002357', 'lbl': 'obsolete Dysphasia', 'desc': 'label: obsolete Dysphasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002359', 'url': 'http://purl.obolibrary.org/obo/HP_0002359', 'lbl': 'Frequent falls', 'desc': 'label: Frequent falls\ndefinition : \nsynonyms :Frequent falls\n'}


{'id': 'HP_0002360', 'url': 'http://purl.obolibrary.org/obo/HP_0002360', 'lbl': 'Sleep disturbance', 'desc': 'label: Sleep disturbance\ndefinition : An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness.\nsynonyms :Difficulty sleeping; Sleep disturbances; Sleep dysfunction; Trouble sleeping\n'}


{'id': 'HP_0002361', 'url': 'http://purl.obolibrary.org/obo/HP_0002361', 'lbl': 'Psychomotor deterioration', 'desc': 'label: Psychomotor deterioration\ndefinition : Loss of previously present mental and motor abilities.\nsynonyms :Psychomotor degeneration\n'}


{'id': 'HP_0002362', 'url': 'http://purl.obolibrary.org/obo/HP_0002362', 'lbl': 'Shuffling gait', 'desc': "label: Shuffling gait\ndefinition : A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground.\nsynonyms :Shuffled walk\n"}


{'id': 'HP_0002363', 'url': 'http://purl.obolibrary.org/obo/HP_0002363', 'lbl': 'Abnormal brainstem morphology', 'desc': 'label: Abnormal brainstem morphology\ndefinition : An anomaly of the brainstem.\nsynonyms :Abnormal shape of brainstem; Abnormality of brainstem morphology; Abnormality of the brainstem\n'}


{'id': 'HP_0002365', 'url': 'http://purl.obolibrary.org/obo/HP_0002365', 'lbl': 'Hypoplasia of the brainstem', 'desc': 'label: Hypoplasia of the brainstem\ndefinition : Underdevelopment of the brainstem.\nsynonyms :Brainstem hypoplasia; Hypoplastic brain stem; Hypoplastic brainstem; Small brainstem; Underdeveloped brainstem\n'}


{'id': 'HP_0002366', 'url': 'http://purl.obolibrary.org/obo/HP_0002366', 'lbl': 'Abnormal lower motor neuron morphology', 'desc': 'label: Abnormal lower motor neuron morphology\ndefinition : Any structural anomaly of the lower motor neuron.\nsynonyms :Lower motor neuron disease; Lower motor neuron manifestations; Lower motor neuron signs\n'}


{'id': 'HP_0002367', 'url': 'http://purl.obolibrary.org/obo/HP_0002367', 'lbl': 'Visual hallucinations', 'desc': 'label: Visual hallucinations\ndefinition : Visual perceptions that are not elicited by a corresponding stimulus from the outside world.\nsynonyms :Visual hallucinations\n'}


{'id': 'HP_0002370', 'url': 'http://purl.obolibrary.org/obo/HP_0002370', 'lbl': 'Poor coordination', 'desc': 'label: Poor coordination\ndefinition : \nsynonyms :Poor coordination\n'}


{'id': 'HP_0002371', 'url': 'http://purl.obolibrary.org/obo/HP_0002371', 'lbl': 'Loss of speech', 'desc': 'label: Loss of speech\ndefinition : \nsynonyms :Loss of speech\n'}


{'id': 'HP_0002372', 'url': 'http://purl.obolibrary.org/obo/HP_0002372', 'lbl': 'Normal interictal EEG', 'desc': 'label: Normal interictal EEG\ndefinition : Lack of observable abnormal electroencephalographic (EEG) patterns in an individual with a history of seizures. About half of individuals with epilepsy show interictal epileptiform discharges upon the first investigation. The yield can be increased by repeated studies, sleep studies, or by ambulatory EEG recordings over 24 hours. Normal interictal EEG is a sign that can be useful in the differential diagnosis.\nsynonyms :\n'}


{'id': 'HP_0002373', 'url': 'http://purl.obolibrary.org/obo/HP_0002373', 'lbl': 'Febrile seizure (within the age range of 3 months to 6 years)', 'desc': 'label: Febrile seizure (within the age range of 3 months to 6 years)\ndefinition : A febrile seizure is any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in children between the ages of 3 months and 6 years.\nsynonyms :Febrile convulsion; Febrile seizures; Fever induced seizures; Seizures, febrile, in early childhood; Seizures, generalized, associated with fever\n'}


{'id': 'HP_0002374', 'url': 'http://purl.obolibrary.org/obo/HP_0002374', 'lbl': 'Diminished movement', 'desc': 'label: Diminished movement\ndefinition : \nsynonyms :Diminished movement\n'}


{'id': 'HP_0002375', 'url': 'http://purl.obolibrary.org/obo/HP_0002375', 'lbl': 'Hypokinesia', 'desc': 'label: Hypokinesia\ndefinition : Abnormally diminished motor activity. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.\nsynonyms :Decreased muscle movement; Decreased spontaneous movement; Decreased spontaneous movements\n'}


{'id': 'HP_0002376', 'url': 'http://purl.obolibrary.org/obo/HP_0002376', 'lbl': 'Developmental regression', 'desc': 'label: Developmental regression\ndefinition : Loss of developmental skills, as manifested by loss of developmental milestones.\nsynonyms :Loss of developmental milestones; Mental deterioration in childhood; Neurodevelopmental regression; Psychomotor regression; Psychomotor regression beginning in infancy; Psychomotor regression in infants; Psychomotor regression, progressive\n'}


{'id': 'HP_0002377', 'url': 'http://purl.obolibrary.org/obo/HP_0002377', 'lbl': 'obsolete Paraganglioma-related cranial nerve palsy', 'desc': 'label: obsolete Paraganglioma-related cranial nerve palsy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002378', 'url': 'http://purl.obolibrary.org/obo/HP_0002378', 'lbl': 'Hand tremor', 'desc': 'label: Hand tremor\ndefinition : An unintentional, oscillating to-and-fro muscle movement affecting the hand.\nsynonyms :Hand tremor; Tremor of hand; Tremor of hands; tremors in hands\n'}


{'id': 'HP_0002380', 'url': 'http://purl.obolibrary.org/obo/HP_0002380', 'lbl': 'Fasciculations', 'desc': 'label: Fasciculations\ndefinition : Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units.\nsynonyms :Fasciculation; Muscle fasciculation; Muscle twitch\n'}


{'id': 'HP_0002381', 'url': 'http://purl.obolibrary.org/obo/HP_0002381', 'lbl': 'Aphasia', 'desc': 'label: Aphasia\ndefinition : An acquired language impairment of some or all of the abilities to produce or comprehend speech and to read or write.\nsynonyms :Difficulty finding words; Losing words; Loss of words\n'}


{'id': 'HP_0002383', 'url': 'http://purl.obolibrary.org/obo/HP_0002383', 'lbl': 'Infectious encephalitis', 'desc': 'label: Infectious encephalitis\ndefinition : A disorder of the brain caused by an infectious agent that presents with fever, headache, and an altered level of consciousness. There may also be focal or multifocal neurologic deficits, and focal or generalized seizure activity.\nsynonyms :Brain inflammation\n'}


{'id': 'HP_0002384', 'url': 'http://purl.obolibrary.org/obo/HP_0002384', 'lbl': 'Focal impaired awareness seizure', 'desc': "label: Focal impaired awareness seizure\ndefinition : Focal impaired awareness seizure (or focal seizure with impaired or lost awareness) is a type of focal-onset seizure characterized by some degree (which may be partial) of impairment of the person's awareness of themselves or their surroundings at any point during the seizure.\nsynonyms :Complex focal seizures; Complex partial seizure; Complex partial seizures; Dyscognitive seizures; Focal dyscognitive seizure; Focal impaired awareness seizures; Focal seizure with impairment of awareness; Focal seizure with loss of awareness; Focal seizures with impairment of consciousness or awareness; Localised dyscognitive seizure; Localised seizure with impaired awareness; Localised seizure with loss of awareness; Localized dyscognitive seizure; Localized seizure with impaired awareness; Localized seizure with loss of awareness; Partial dyscognitive seizure; Partial seizure with impairment of awareness; Partial seizure with loss of awareness\n"}


{'id': 'HP_0002385', 'url': 'http://purl.obolibrary.org/obo/HP_0002385', 'lbl': 'Paraparesis', 'desc': 'label: Paraparesis\ndefinition : Weakness or partial paralysis in the lower limbs.\nsynonyms :Partial paralysis of legs\n'}


{'id': 'HP_0002389', 'url': 'http://purl.obolibrary.org/obo/HP_0002389', 'lbl': 'Cavum septum pellucidum', 'desc': 'label: Cavum septum pellucidum\ndefinition : If the two laminae of the septum pellucidum are not fused then a fluid-filled space or cavum is present. The cavum septum pellucidum is present at birth but usually obliterates by the age of 3 to 6 months. It is up to 1cm in width and the walls are parallel. It is an enclosed space and is not part of the ventricular system or connected with the subarachnoid space.\nsynonyms :Large cavum septi pellucidi; Persistent cavum septum pellucidum; Widened cavum septum pellucidum\n'}


{'id': 'HP_0002390', 'url': 'http://purl.obolibrary.org/obo/HP_0002390', 'lbl': 'Spinal arteriovenous malformation', 'desc': 'label: Spinal arteriovenous malformation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002392', 'url': 'http://purl.obolibrary.org/obo/HP_0002392', 'lbl': 'EEG with polyspike wave complexes', 'desc': 'label: EEG with polyspike wave complexes\ndefinition : The presence of complexes of repetitive spikes and waves in EEG.\nsynonyms :EEG: spike and multispike waves, 3-4 hz\n'}


{'id': 'HP_0002395', 'url': 'http://purl.obolibrary.org/obo/HP_0002395', 'lbl': 'Lower limb hyperreflexia', 'desc': 'label: Lower limb hyperreflexia\ndefinition : \nsynonyms :Brisk lower extremity reflexes; Hyperreflexia in lower limbs; Hyperreflexia in the lower limbs; Increased deep tendon reflexes in the lower limbs; Leg hyperreflexia; Overactive lower leg reflex\n'}


{'id': 'HP_0002396', 'url': 'http://purl.obolibrary.org/obo/HP_0002396', 'lbl': 'Cogwheel rigidity', 'desc': 'label: Cogwheel rigidity\ndefinition : A type of rigidity in which a muscle responds with cogwheellike jerks to the use of constant force in bending the limb (i.e., it gives way in little, repeated jerks when the muscle is passively stretched).\nsynonyms :\n'}


{'id': 'HP_0002398', 'url': 'http://purl.obolibrary.org/obo/HP_0002398', 'lbl': 'Degeneration of anterior horn cells', 'desc': 'label: Degeneration of anterior horn cells\ndefinition : \nsynonyms :Anterior horn cell loss; Degeneration of alpha-motor neurons in anterior horn cells of the spinal cord; Degeneration of spinal cord anterior horn cells; Loss of spinal cord anterior horn cells; Progressive loss of anterior horn cells; Spinal cord anterior horn cell degeneration\n'}


{'id': 'HP_0002401', 'url': 'http://purl.obolibrary.org/obo/HP_0002401', 'lbl': 'Stroke-like episode', 'desc': 'label: Stroke-like episode\ndefinition : No consensus exists on what a stroke-like episode is, but these episodes can be functionally defined as a new neurological deficit, occurring with or without the context of seizures, which last longer than 24 hours.\nsynonyms :Stroke-like episodes; Strokelike episodes\n'}


{'id': 'HP_0002403', 'url': 'http://purl.obolibrary.org/obo/HP_0002403', 'lbl': 'Positive Romberg sign', 'desc': 'label: Positive Romberg sign\ndefinition : The patient stands with the feet placed together and balance and is asked to close his or her eyes. A loss of balance upon eye closure is a positive Romberg sign and is interpreted as indicating a deficit in proprioception.\nsynonyms :\n'}


{'id': 'HP_0002404', 'url': 'http://purl.obolibrary.org/obo/HP_0002404', 'lbl': 'Thickened superior cerebellar peduncle', 'desc': 'label: Thickened superior cerebellar peduncle\ndefinition : Increased width of the superior cerebellar peduncle.\nsynonyms :Thick cerebellar peduncles\n'}


{'id': 'HP_0002406', 'url': 'http://purl.obolibrary.org/obo/HP_0002406', 'lbl': 'Limb dysmetria', 'desc': 'label: Limb dysmetria\ndefinition : A type of dysmetria involving the limbs.\nsynonyms :Uncoordinated limb movement\n'}


{'id': 'HP_0002408', 'url': 'http://purl.obolibrary.org/obo/HP_0002408', 'lbl': 'Cerebral arteriovenous malformation', 'desc': 'label: Cerebral arteriovenous malformation\ndefinition : An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the brain.\nsynonyms :Cerebral AV malformation\n'}


{'id': 'HP_0002410', 'url': 'http://purl.obolibrary.org/obo/HP_0002410', 'lbl': 'Aqueductal stenosis', 'desc': 'label: Aqueductal stenosis\ndefinition : Stenosis of the cerebral aqueduct (also known as the mesencephalic duct, aqueductus mesencephali, or aqueduct of Sylvius), which connects the third cerebral ventricle in the diencephalon to the fourth ventricle, which is between the pons and cerebellum.\nsynonyms :Aqueduct of Sylvius stenosis; Aqueduct stenosis; Narrowing of aqueduct of Sylvius\n'}


{'id': 'HP_0002411', 'url': 'http://purl.obolibrary.org/obo/HP_0002411', 'lbl': 'Myokymia', 'desc': 'label: Myokymia\ndefinition : Myokymia consists of involuntary, fine, continuous, undulating contractions that spread across the affected striated muscle.\nsynonyms :\n'}


{'id': 'HP_0002414', 'url': 'http://purl.obolibrary.org/obo/HP_0002414', 'lbl': 'Spina bifida', 'desc': 'label: Spina bifida\ndefinition : Incomplete closure of the embryonic neural tube, whereby some vertebral arches remain unfused and open. The mildest form is spina bifida occulta, followed by meningocele and meningomyelocele.\nsynonyms :Split spine\n'}


{'id': 'HP_0002415', 'url': 'http://purl.obolibrary.org/obo/HP_0002415', 'lbl': 'Leukodystrophy', 'desc': 'label: Leukodystrophy\ndefinition : Leukodystrophy refers to deterioration of white matter of the brain resulting from degeneration of myelin sheaths in the CNS. Their basic defect is directly related to the synthesis and maintenance of myelin membranes. Symmetric white matter involvement at MRI is a typical finding in patients with leukodystrophies.\nsynonyms :Degeneration of white matter of brain\n'}


{'id': 'HP_0002416', 'url': 'http://purl.obolibrary.org/obo/HP_0002416', 'lbl': 'Subependymal cysts', 'desc': 'label: Subependymal cysts\ndefinition : Cerebral cysts, usually located in the wall of the caudate nucleus or in the caudothalamic groove. They are found in up to 5.2% of all neonates, using transfontanellar ultrasound in the first days of life.\nsynonyms :Subependymal germinolytic cyst; Subependymal pseudocyst\n'}


{'id': 'HP_0002418', 'url': 'http://purl.obolibrary.org/obo/HP_0002418', 'lbl': 'Abnormal midbrain morphology', 'desc': 'label: Abnormal midbrain morphology\ndefinition : An abnormality of the midbrain, which has as its parts the tectum, cerebral peduncle, midbrain tegmentum and cerebral aqueduct.\nsynonyms :Abnormal shape of midbrain; Abnormality of midbrain morphology; Abnormality of the mesencephalon; Abnormality of the midbrain\n'}


{'id': 'HP_0002419', 'url': 'http://purl.obolibrary.org/obo/HP_0002419', 'lbl': 'Molar tooth sign on MRI', 'desc': 'label: Molar tooth sign on MRI\ndefinition : An abnormal appearance of the midbrain in axial magnetic resonance imaging in which the elongated superior cerebellar peduncles give the midbrain an appearance reminiscent of a molar or wisdom tooth.\nsynonyms :Molar tooth sign; Molar tooth sign on brain imaging; Molar tooth sign on imaging\n'}


{'id': 'HP_0002421', 'url': 'http://purl.obolibrary.org/obo/HP_0002421', 'lbl': 'Poor head control', 'desc': 'label: Poor head control\ndefinition : Difficulty to maintain correct position of the head while standing or sitting.\nsynonyms :Poor head control\n'}


{'id': 'HP_0002423', 'url': 'http://purl.obolibrary.org/obo/HP_0002423', 'lbl': 'Long-tract signs', 'desc': 'label: Long-tract signs\ndefinition : Long-tract signs refer to symptoms that are attributable to the involvement of the long fiber tracts in the spinal cord, which connect the spinal cord to the brain and mediate spinal and motor functions.\nsynonyms :Long tract signs\n'}


{'id': 'HP_0002425', 'url': 'http://purl.obolibrary.org/obo/HP_0002425', 'lbl': 'Anarthria', 'desc': 'label: Anarthria\ndefinition : A defect in the motor ability that enables speech.\nsynonyms :Loss of articulate speech\n'}


{'id': 'HP_0002427', 'url': 'http://purl.obolibrary.org/obo/HP_0002427', 'lbl': 'Expressive aphasia', 'desc': "label: Expressive aphasia\ndefinition : Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it.\nsynonyms :Broca's aphasia; Loss of expressive speech; Motor aphasia; Non-fluent aphasia\n"}


{'id': 'HP_0002435', 'url': 'http://purl.obolibrary.org/obo/HP_0002435', 'lbl': 'Meningocele', 'desc': 'label: Meningocele\ndefinition : Protrusion of the meninges through a defect of the skull or vertebral column.\nsynonyms :\n'}


{'id': 'HP_0002436', 'url': 'http://purl.obolibrary.org/obo/HP_0002436', 'lbl': 'Occipital meningocele', 'desc': 'label: Occipital meningocele\ndefinition : A herniation of meninges through a congenital bone defect in the skull in the occipital region.\nsynonyms :\n'}


{'id': 'HP_0002438', 'url': 'http://purl.obolibrary.org/obo/HP_0002438', 'lbl': 'Cerebellar malformation', 'desc': 'label: Cerebellar malformation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002439', 'url': 'http://purl.obolibrary.org/obo/HP_0002439', 'lbl': 'Frontolimbic dementia', 'desc': 'label: Frontolimbic dementia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002442', 'url': 'http://purl.obolibrary.org/obo/HP_0002442', 'lbl': 'Dyscalculia', 'desc': 'label: Dyscalculia\ndefinition : A specific learning disability involving mathematics and arithmetic.\nsynonyms :Difficulty making arithmetical calculations\n'}


{'id': 'HP_0002444', 'url': 'http://purl.obolibrary.org/obo/HP_0002444', 'lbl': 'Hypothalamic hamartoma', 'desc': 'label: Hypothalamic hamartoma\ndefinition : The presence of a hamartoma of the hypothalamus.\nsynonyms :\n'}


{'id': 'HP_0002445', 'url': 'http://purl.obolibrary.org/obo/HP_0002445', 'lbl': 'Tetraplegia', 'desc': 'label: Tetraplegia\ndefinition : Paralysis of all four limbs, and trunk of the body below the level of an associated injury to the spinal cord. The etiology of quadriplegia is similar to that of paraplegia except that the lesion is in the cervical spinal cord rather than in the thoracic or lumbar segments of the spinal cord.\nsynonyms :Paralysis of all four limbs; Quadriplegia\n'}


{'id': 'HP_0002446', 'url': 'http://purl.obolibrary.org/obo/HP_0002446', 'lbl': 'Astrocytosis', 'desc': 'label: Astrocytosis\ndefinition : Proliferation of astrocytes in the area of a lesion of the central nervous system.\nsynonyms :Increase in astrocyte number\n'}


{'id': 'HP_0002448', 'url': 'http://purl.obolibrary.org/obo/HP_0002448', 'lbl': 'Progressive encephalopathy', 'desc': 'label: Progressive encephalopathy\ndefinition : \nsynonyms :Progressive brain disease\n'}


{'id': 'HP_0002450', 'url': 'http://purl.obolibrary.org/obo/HP_0002450', 'lbl': 'Abnormal motor neuron morphology', 'desc': 'label: Abnormal motor neuron morphology\ndefinition : Any structural anomaly that affects the motor neuron.\nsynonyms :Abnormal shape of motor neuron\n'}


{'id': 'HP_0002451', 'url': 'http://purl.obolibrary.org/obo/HP_0002451', 'lbl': 'Limb dystonia', 'desc': 'label: Limb dystonia\ndefinition : A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the limbs.\nsynonyms :\n'}


{'id': 'HP_0002453', 'url': 'http://purl.obolibrary.org/obo/HP_0002453', 'lbl': 'Abnormal globus pallidus morphology', 'desc': 'label: Abnormal globus pallidus morphology\ndefinition : An abnormality of the globus pallidus.\nsynonyms :\n'}


{'id': 'HP_0002454', 'url': 'http://purl.obolibrary.org/obo/HP_0002454', 'lbl': 'Eye of the tiger anomaly of globus pallidus', 'desc': 'label: Eye of the tiger anomaly of globus pallidus\ndefinition : The presence, on T2-weighted magnetic resonance imaging, of markedly low signal intensity of the globus pallidus that surrounds a central region of high signal intensity in the anteromedial globus pallidus, producing an eye-of-the-tiger appearance. The sign is thought to represent iron accumulation in the globus pallidus.\nsynonyms :\n'}


{'id': 'HP_0002457', 'url': 'http://purl.obolibrary.org/obo/HP_0002457', 'lbl': 'Abnormal head movements', 'desc': 'label: Abnormal head movements\ndefinition : \nsynonyms :Abnormal head movements\n'}


{'id': 'HP_0002459', 'url': 'http://purl.obolibrary.org/obo/HP_0002459', 'lbl': 'obsolete Dysautonomia', 'desc': 'label: obsolete Dysautonomia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002460', 'url': 'http://purl.obolibrary.org/obo/HP_0002460', 'lbl': 'Distal muscle weakness', 'desc': 'label: Distal muscle weakness\ndefinition : Reduced strength of the musculature of the distal extremities.\nsynonyms :Distal limb muscle weakness; Distal limb weakness; Distal muscular weakness; Distal paresis; Muscle weakness, distal; Muscle weakness, distal limbs, due to neuronopathy; Weakness of distal muscles; Weakness of outermost muscles; Distal limb muscle weakness due to peripheral neuropathy\n'}


{'id': 'HP_0002461', 'url': 'http://purl.obolibrary.org/obo/HP_0002461', 'lbl': 'Dense calcifications in the cerebellar dentate nucleus', 'desc': 'label: Dense calcifications in the cerebellar dentate nucleus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002463', 'url': 'http://purl.obolibrary.org/obo/HP_0002463', 'lbl': 'Language impairment', 'desc': 'label: Language impairment\ndefinition : Language impairment is a deficit in comprehension or production of language that includes reduced vocabulary, limited sentence structure, or impairments in written or spoken communication. Language abilities are substantially and quantifiably below age expectations.\nsynonyms :Language disorder\n'}


{'id': 'HP_0002464', 'url': 'http://purl.obolibrary.org/obo/HP_0002464', 'lbl': 'Spastic dysarthria', 'desc': 'label: Spastic dysarthria\ndefinition : A type of dysarthria related to bilateral damage of the upper motor neuron tracts of the pyramidal and extra- pyramidal tracts. Speech of affected individuals is slow, effortful, and has a harsh vocal quality.\nsynonyms :Rigid dysarthria\n'}


{'id': 'HP_0002465', 'url': 'http://purl.obolibrary.org/obo/HP_0002465', 'lbl': 'Poor speech', 'desc': 'label: Poor speech\ndefinition : \nsynonyms :Problems speaking; Poor speech; Difficulty speaking\n'}


{'id': 'HP_0002470', 'url': 'http://purl.obolibrary.org/obo/HP_0002470', 'lbl': 'Nonprogressive cerebellar ataxia', 'desc': 'label: Nonprogressive cerebellar ataxia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002472', 'url': 'http://purl.obolibrary.org/obo/HP_0002472', 'lbl': 'Small cerebral cortex', 'desc': 'label: Small cerebral cortex\ndefinition : Reduced size of the cerebral cortex.\nsynonyms :Decreased volume of cerebral cortex\n'}


{'id': 'HP_0002474', 'url': 'http://purl.obolibrary.org/obo/HP_0002474', 'lbl': 'Expressive language delay', 'desc': 'label: Expressive language delay\ndefinition : A delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.\nsynonyms :Communication delay; Deficit in expressive language\n'}


{'id': 'HP_0002475', 'url': 'http://purl.obolibrary.org/obo/HP_0002475', 'lbl': 'Myelomeningocele', 'desc': 'label: Myelomeningocele\ndefinition : Protrusion of the meninges and portions of the spinal cord through a defect of the vertebral column.\nsynonyms :Meningomyelocele; Spina bifida cystica\n'}


{'id': 'HP_0002476', 'url': 'http://purl.obolibrary.org/obo/HP_0002476', 'lbl': 'Primitive reflex', 'desc': 'label: Primitive reflex\ndefinition : The primitive reflexes are a group of behavioural motor responses which are found in normal early development, are subsequently inhibited, but may be released from inhibition by cerebral, usually frontal, damage. They are thus part of a broader group of reflexes which reflect release phenomena, such as exaggerated stretch reflexes and extensor plantars. They do however involve more complex motor responses than such simple stretch reflexes, and are often a normal feature in the neonate or infant.\nsynonyms :Archaic reflex; Primitive reflexes\n'}


{'id': 'HP_0002478', 'url': 'http://purl.obolibrary.org/obo/HP_0002478', 'lbl': 'Progressive spastic quadriplegia', 'desc': 'label: Progressive spastic quadriplegia\ndefinition : \nsynonyms :Progressive spastic quadriparesis\n'}


{'id': 'HP_0002480', 'url': 'http://purl.obolibrary.org/obo/HP_0002480', 'lbl': 'Hepatic encephalopathy', 'desc': 'label: Hepatic encephalopathy\ndefinition : Central nervous system dysfunction in association with liver failure and characterized clinically (depending on degree of severity) by lethargy, confusion, nystagmus, decorticate posturing, spasticity, and bilateral Babinski reflexes.\nsynonyms :\n'}


{'id': 'HP_0002483', 'url': 'http://purl.obolibrary.org/obo/HP_0002483', 'lbl': 'Bulbar signs', 'desc': 'label: Bulbar signs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002486', 'url': 'http://purl.obolibrary.org/obo/HP_0002486', 'lbl': 'Myotonia', 'desc': 'label: Myotonia\ndefinition : An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation.\nsynonyms :Delayed relaxation of muscle fibers after contraction; Delayed relaxation of muscle fibres after contraction\n'}


{'id': 'HP_0002487', 'url': 'http://purl.obolibrary.org/obo/HP_0002487', 'lbl': 'Hyperkinetic movements', 'desc': 'label: Hyperkinetic movements\ndefinition : Motor hyperactivity with excessive movement of muscles of the body as a whole.\nsynonyms :Hyperkinesia; Hyperkinesis; Muscle spasms\n'}


{'id': 'HP_0002488', 'url': 'http://purl.obolibrary.org/obo/HP_0002488', 'lbl': 'Acute leukemia', 'desc': 'label: Acute leukemia\ndefinition : A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).\nsynonyms :Acute blood cancer; Acute leukaemia; Acute leukemias\n'}


{'id': 'HP_0002490', 'url': 'http://purl.obolibrary.org/obo/HP_0002490', 'lbl': 'Increased CSF lactate', 'desc': 'label: Increased CSF lactate\ndefinition : Increased concentration of lactate in the cerebrospinal fluid.\nsynonyms :Hyperlactatorachia; Increased CSF lactic acid; Increased cerebrospinal fluid lactate\n'}


{'id': 'HP_0002491', 'url': 'http://purl.obolibrary.org/obo/HP_0002491', 'lbl': 'Spasticity of facial muscles', 'desc': 'label: Spasticity of facial muscles\ndefinition : Spasticity of one or more muscles innervated by the facial nerve.\nsynonyms :Spasticity of the facial muscles; Increased stiffness of facial muscles; Increased tone of facial muscles\n'}


{'id': 'HP_0002492', 'url': 'http://purl.obolibrary.org/obo/HP_0002492', 'lbl': 'Morphological abnormality of the corticospinal tract', 'desc': 'label: Morphological abnormality of the corticospinal tract\ndefinition : Abnormality of the corticospinal tract, which is the chief element of the pyramidal system (the principle motor tract) and is the only direct connection between the cerebrum and the spinal cord.\nsynonyms :Abnormality of the corticospinal tract; Involvement of the corticospinal pathways\n'}


{'id': 'HP_0002493', 'url': 'http://purl.obolibrary.org/obo/HP_0002493', 'lbl': 'Upper motor neuron dysfunction', 'desc': 'label: Upper motor neuron dysfunction\ndefinition : A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.\nsynonyms :Corticospinal tract dysfunction; Pyramidal tract dysfunction\n'}


{'id': 'HP_0002494', 'url': 'http://purl.obolibrary.org/obo/HP_0002494', 'lbl': 'Abnormal rapid eye movement sleep', 'desc': 'label: Abnormal rapid eye movement sleep\ndefinition : Abnormality of REM sleep. Phases of REM sleep are characterized by desynchronized EEG patterns, increases in heart rate and blood pressure, sympathetic activation, and a profound loss of muscle tonus except for the eye and middle-ear muscles. There are then phases of rapid eye movements.\nsynonyms :Abnormal REM sleep\n'}


{'id': 'HP_0002495', 'url': 'http://purl.obolibrary.org/obo/HP_0002495', 'lbl': 'Impaired vibratory sensation', 'desc': 'label: Impaired vibratory sensation\ndefinition : A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient.\nsynonyms :Decreased vibration sense; Decreased vibratory sense; Diminished vibratory sense; Hypopallesthesia; Impaired vibratory sensation; Impaired vibratory sense\n'}


{'id': 'HP_0002497', 'url': 'http://purl.obolibrary.org/obo/HP_0002497', 'lbl': 'Spastic ataxia', 'desc': 'label: Spastic ataxia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002500', 'url': 'http://purl.obolibrary.org/obo/HP_0002500', 'lbl': 'Abnormal cerebral white matter morphology', 'desc': 'label: Abnormal cerebral white matter morphology\ndefinition : An abnormality of the cerebral white matter.\nsynonyms :Abnormality of subcortical white matter; Abnormality of the cerebral white matter; Cerebral white matter abnormalities; Leukoaraiosis; White matter abnormalities; White matter alterations; Cortical white matter abnormalities seen on MRI\n'}


{'id': 'HP_0002501', 'url': 'http://purl.obolibrary.org/obo/HP_0002501', 'lbl': 'Spasticity of pharyngeal muscles', 'desc': 'label: Spasticity of pharyngeal muscles\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002503', 'url': 'http://purl.obolibrary.org/obo/HP_0002503', 'lbl': 'Spinocerebellar tract degeneration', 'desc': 'label: Spinocerebellar tract degeneration\ndefinition : \nsynonyms :Degeneration of the spinocerebellar tracts; Spinocerebellar degeneration\n'}


{'id': 'HP_0002504', 'url': 'http://purl.obolibrary.org/obo/HP_0002504', 'lbl': 'Calcification of the small brain vessels', 'desc': 'label: Calcification of the small brain vessels\ndefinition : Deposition of calcium salts within small blood vessels of the brain.\nsynonyms :\n'}


{'id': 'HP_0002505', 'url': 'http://purl.obolibrary.org/obo/HP_0002505', 'lbl': 'Loss of ambulation', 'desc': 'label: Loss of ambulation\ndefinition : Inability to walk in a person who previous had the ability to walk.\nsynonyms :Loss of ability to walk\n'}


{'id': 'HP_0002506', 'url': 'http://purl.obolibrary.org/obo/HP_0002506', 'lbl': 'Diffuse cerebral atrophy', 'desc': 'label: Diffuse cerebral atrophy\ndefinition : Diffuse unlocalised atrophy affecting the cerebrum.\nsynonyms :Cerebral atrophy, diffuse\n'}


{'id': 'HP_0002507', 'url': 'http://purl.obolibrary.org/obo/HP_0002507', 'lbl': 'Semilobar holoprosencephaly', 'desc': 'label: Semilobar holoprosencephaly\ndefinition : A type of holoprosencephaly in which the left and right frontal and parietal lobes are fused and the interhemispheric fissure is only present posteriorly.\nsynonyms :\n'}


{'id': 'HP_0002508', 'url': 'http://purl.obolibrary.org/obo/HP_0002508', 'lbl': 'Brainstem dysplasia', 'desc': 'label: Brainstem dysplasia\ndefinition : A developmental structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord.\nsynonyms :Brainstem hypoplasia/dysplasia; Malformation of brainstem structures\n'}


{'id': 'HP_0002509', 'url': 'http://purl.obolibrary.org/obo/HP_0002509', 'lbl': 'Limb hypertonia', 'desc': 'label: Limb hypertonia\ndefinition : \nsynonyms :Increased muscle tone of arm or leg\n'}


{'id': 'HP_0002510', 'url': 'http://purl.obolibrary.org/obo/HP_0002510', 'lbl': 'Spastic tetraplegia', 'desc': 'label: Spastic tetraplegia\ndefinition : Spastic paralysis affecting all four limbs.\nsynonyms :Spastic quadriplegia\n'}


{'id': 'HP_0002511', 'url': 'http://purl.obolibrary.org/obo/HP_0002511', 'lbl': 'Alzheimer disease', 'desc': 'label: Alzheimer disease\ndefinition : A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads.\nsynonyms :Alzheimer disease; Late-onset form of familial Alzheimer disease\n'}


{'id': 'HP_0002512', 'url': 'http://purl.obolibrary.org/obo/HP_0002512', 'lbl': 'Brain stem compression', 'desc': 'label: Brain stem compression\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002514', 'url': 'http://purl.obolibrary.org/obo/HP_0002514', 'lbl': 'Cerebral calcification', 'desc': 'label: Cerebral calcification\ndefinition : The presence of calcium deposition within brain structures.\nsynonyms :Abnormal deposits of calcium in the brain; Brain calcification; Intracerebral calcifications; Intracranial calcification; Intracranial calcifications\n'}


{'id': 'HP_0002515', 'url': 'http://purl.obolibrary.org/obo/HP_0002515', 'lbl': 'Waddling gait', 'desc': 'label: Waddling gait\ndefinition : Weakness of the hip girdle and upper thigh muscles, for instance in myopathies, leads to an instability of the pelvis on standing and walking. If the muscles extending the hip joint are affected, the posture in that joint becomes flexed and lumbar lordosis increases. The patients usually have difficulties standing up from a sitting position. Due to weakness in the gluteus medius muscle, the hip on the side of the swinging leg drops with each step (referred to as Trendelenburg sign). The gait appears waddling. The patients frequently attempt to counteract the dropping of the hip on the swinging side by bending the trunk towards the side which is in the stance phase (in the German language literature this is referred to as Duchenne sign). Similar gait patterns can be caused by orthopedic conditions when the origin and the insertion site of the gluteus medius muscle are closer to each other than normal, for instance due to a posttraumatic elevation of the trochanter or pseudarthrosis of the femoral neck.\nsynonyms :Waddling gait; Waddling walk\n'}


{'id': 'HP_0002516', 'url': 'http://purl.obolibrary.org/obo/HP_0002516', 'lbl': 'Increased intracranial pressure', 'desc': 'label: Increased intracranial pressure\ndefinition : An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid.\nsynonyms :Intracranial hypertension; Intracranial pressure elevation; Rise in pressure inside skull; Pseudotumor cerebri\n'}


{'id': 'HP_0002518', 'url': 'http://purl.obolibrary.org/obo/HP_0002518', 'lbl': 'Abnormal periventricular white matter morphology', 'desc': 'label: Abnormal periventricular white matter morphology\ndefinition : A structural abnormality of the myelinated axons (white matter) located near the cerebral ventricles.\nsynonyms :Abnormality of the periventricular white matter; Periventricular white matter abnormalities\n'}


{'id': 'HP_0002519', 'url': 'http://purl.obolibrary.org/obo/HP_0002519', 'lbl': 'Hypnagogic hallucinations', 'desc': 'label: Hypnagogic hallucinations\ndefinition : Fleeting perceptual experiences that occur during the transition from wakefulness to sleep.\nsynonyms :\n'}


{'id': 'HP_0002521', 'url': 'http://purl.obolibrary.org/obo/HP_0002521', 'lbl': 'Hypsarrhythmia', 'desc': 'label: Hypsarrhythmia\ndefinition : Hypsarrhythmia is abnormal interictal high amplitude waves and a background of irregular spikes. There is continuous (during wakefulness), high-amplitude (>200 Hz), generalized polymorphic slowing with no organized background and multifocal spikes demonstrated by electroencephalography (EEG).\nsynonyms :Hypsarrhythmia by EEG\n'}


{'id': 'HP_0002522', 'url': 'http://purl.obolibrary.org/obo/HP_0002522', 'lbl': 'Areflexia of lower limbs', 'desc': 'label: Areflexia of lower limbs\ndefinition : Inability to elicit tendon reflexes in the lower limbs.\nsynonyms :Absent lower limb tendon reflexes; Areflexia in lower limbs; Areflexia of the lower limbs; Areflexia, lower limbs\n'}


{'id': 'HP_0002524', 'url': 'http://purl.obolibrary.org/obo/HP_0002524', 'lbl': 'Cataplexy', 'desc': 'label: Cataplexy\ndefinition : A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions.\nsynonyms :\n'}


{'id': 'HP_0002526', 'url': 'http://purl.obolibrary.org/obo/HP_0002526', 'lbl': 'Deficit in nonword repetition', 'desc': 'label: Deficit in nonword repetition\ndefinition : Impaired ability to repeat non-word sounds. Nonword repetition (NWR) is a measure of short-term phonological memory.\nsynonyms :\n'}


{'id': 'HP_0002527', 'url': 'http://purl.obolibrary.org/obo/HP_0002527', 'lbl': 'Falls', 'desc': 'label: Falls\ndefinition : \nsynonyms :Falls\n'}


{'id': 'HP_0002528', 'url': 'http://purl.obolibrary.org/obo/HP_0002528', 'lbl': 'Granulovacuolar degeneration', 'desc': 'label: Granulovacuolar degeneration\ndefinition : Electron-dense granules within double membrane-bound cytoplasmic vacuoles.\nsynonyms :\n'}


{'id': 'HP_0002529', 'url': 'http://purl.obolibrary.org/obo/HP_0002529', 'lbl': 'Neuronal loss in central nervous system', 'desc': 'label: Neuronal loss in central nervous system\ndefinition : \nsynonyms :Loss of brain cells; Neuronal loss; Neuronal loss in CNS\n'}


{'id': 'HP_0002530', 'url': 'http://purl.obolibrary.org/obo/HP_0002530', 'lbl': 'Axial dystonia', 'desc': 'label: Axial dystonia\ndefinition : A type of dystonia that affects the midline muscles, i.e., the chest, abdominal, and back muscles.\nsynonyms :Truncal dystonia\n'}


{'id': 'HP_0002533', 'url': 'http://purl.obolibrary.org/obo/HP_0002533', 'lbl': 'Abnormal posturing', 'desc': 'label: Abnormal posturing\ndefinition : Involuntary flexion or extension of the arms and legs.\nsynonyms :\n'}


{'id': 'HP_0002536', 'url': 'http://purl.obolibrary.org/obo/HP_0002536', 'lbl': 'Abnormal cortical gyration', 'desc': 'label: Abnormal cortical gyration\ndefinition : An abnormality of the gyri (i.e., the ridges) of the cerebral cortex of the brain.\nsynonyms :Gyral disorganization; Abnormal gyration; Cerebral gyral anomalies\n'}


{'id': 'HP_0002538', 'url': 'http://purl.obolibrary.org/obo/HP_0002538', 'lbl': 'Abnormal cerebral cortex morphology', 'desc': 'label: Abnormal cerebral cortex morphology\ndefinition : Any structural abnormality of the cerebral cortex.\nsynonyms :Abnormality of the cerebral cortex\n'}


{'id': 'HP_0002539', 'url': 'http://purl.obolibrary.org/obo/HP_0002539', 'lbl': 'Cortical dysplasia', 'desc': 'label: Cortical dysplasia\ndefinition : The presence of developmental dysplasia of the cerebral cortex.\nsynonyms :Neocortical dysplasia\n'}


{'id': 'HP_0002540', 'url': 'http://purl.obolibrary.org/obo/HP_0002540', 'lbl': 'Inability to walk', 'desc': 'label: Inability to walk\ndefinition : Incapability to ambulate.\nsynonyms :Inability to walk; Non-ambulatory\n'}


{'id': 'HP_0002542', 'url': 'http://purl.obolibrary.org/obo/HP_0002542', 'lbl': 'Olivopontocerebellar atrophy', 'desc': 'label: Olivopontocerebellar atrophy\ndefinition : Neuronal degeneration in the cerebellum, pontine nuclei, and inferior olivary nucleus.\nsynonyms :Olivopontocerebellar degeneration\n'}


{'id': 'HP_0002544', 'url': 'http://purl.obolibrary.org/obo/HP_0002544', 'lbl': 'Retrocollis', 'desc': 'label: Retrocollis\ndefinition : A form of torticollis in which the head is drawn back, either due to a permanent contractures of neck extensor muscles, or to a spasmodic contracture.\nsynonyms :\n'}


{'id': 'HP_0002545', 'url': 'http://purl.obolibrary.org/obo/HP_0002545', 'lbl': 'Patchy demyelination of subcortical white matter', 'desc': 'label: Patchy demyelination of subcortical white matter\ndefinition : Patchy loss of myelin from nerve fibers in the central nervous system.\nsynonyms :\n'}


{'id': 'HP_0002546', 'url': 'http://purl.obolibrary.org/obo/HP_0002546', 'lbl': 'Incomprehensible speech', 'desc': 'label: Incomprehensible speech\ndefinition : \nsynonyms :Incomprehensible speech\n'}


{'id': 'HP_0002548', 'url': 'http://purl.obolibrary.org/obo/HP_0002548', 'lbl': 'Parkinsonism with favorable response to dopaminergic medication', 'desc': 'label: Parkinsonism with favorable response to dopaminergic medication\ndefinition : Parkinsonism is a clinical syndrome that is a feature of a number of different diseases, including Parkinson disease itself, other neurodegenerative diseases such as progressive supranuclear palsy, and as a side-effect of some neuroleptic medications. Some but not all individuals with Parkinsonism show responsiveness to dopaminergic medication defined as a substantial reduction of amelioration of the component signs of Parkinsonism (including mainly tremor, bradykinesia, rigidity, and postural instability) upon administration of dopaminergic medication.\nsynonyms :Parkinsonism with favourable response to dopaminergic medication; Favorable response to levodopa; Favourable response to levodopa\n'}


{'id': 'HP_0002549', 'url': 'http://purl.obolibrary.org/obo/HP_0002549', 'lbl': 'Deficit in phonologic short-term memory', 'desc': 'label: Deficit in phonologic short-term memory\ndefinition : Impaired ability to repeat non-word sounds. The test for nonword repetition involves the repetition of nonsensical words of increasing length and complexity and is regarded as a measure of phonological (speech sound) processing and short-term memory\nsynonyms :Deficit in non-word repetition; Impaired non-word repetition\n'}


{'id': 'HP_0002550', 'url': 'http://purl.obolibrary.org/obo/HP_0002550', 'lbl': 'Absent facial hair', 'desc': 'label: Absent facial hair\ndefinition : Absence of facial hair.\nsynonyms :Absent facial hair\n'}


{'id': 'HP_0002552', 'url': 'http://purl.obolibrary.org/obo/HP_0002552', 'lbl': 'Trichodysplasia', 'desc': 'label: Trichodysplasia\ndefinition : Developmental dysplasia of the hair.\nsynonyms :Generalised trichodysplasia; Generalized trichodysplasia\n'}


{'id': 'HP_0002553', 'url': 'http://purl.obolibrary.org/obo/HP_0002553', 'lbl': 'Highly arched eyebrow', 'desc': 'label: Highly arched eyebrow\ndefinition : Increased height of the central portion of the eyebrow, forming a crescent, semicircular, or inverted U shape.\nsynonyms :Arched eyebrows; Broad, arched eyebrows; High, rounded eyebrows; High-arched eyebrows; Highly arched eyebrow; Thick, flared eyebrows; Bowed and upward slanting eyebrows; High arched eyebrows\n'}


{'id': 'HP_0002555', 'url': 'http://purl.obolibrary.org/obo/HP_0002555', 'lbl': 'Absent pubic hair', 'desc': 'label: Absent pubic hair\ndefinition : Absence of pubic hair.\nsynonyms :Absent pubic hair\n'}


{'id': 'HP_0002557', 'url': 'http://purl.obolibrary.org/obo/HP_0002557', 'lbl': 'Hypoplastic nipples', 'desc': 'label: Hypoplastic nipples\ndefinition : Underdevelopment of the nipple.\nsynonyms :Nipple hypoplasia; Small nipples\n'}


{'id': 'HP_0002558', 'url': 'http://purl.obolibrary.org/obo/HP_0002558', 'lbl': 'Supernumerary nipple', 'desc': 'label: Supernumerary nipple\ndefinition : Presence of more than two nipples.\nsynonyms :Accessory nipple; Increased nipple number; accessory mamilla; Accessory nipples; Supernumerary nipples; accessory mamillas\n'}


{'id': 'HP_0002561', 'url': 'http://purl.obolibrary.org/obo/HP_0002561', 'lbl': 'Absent nipple', 'desc': 'label: Absent nipple\ndefinition : Congenital failure to develop, and absence of, the nipple.\nsynonyms :Absent nipple; Absent nipples; Athelia\n'}


{'id': 'HP_0002562', 'url': 'http://purl.obolibrary.org/obo/HP_0002562', 'lbl': 'Low-set nipples', 'desc': 'label: Low-set nipples\ndefinition : Placement of the nipples at a lower than normal location.\nsynonyms :Low-set nipples\n'}


{'id': 'HP_0002563', 'url': 'http://purl.obolibrary.org/obo/HP_0002563', 'lbl': 'Constrictive pericarditis', 'desc': 'label: Constrictive pericarditis\ndefinition : Presence of a thickened, fibrotic pericardium that forms a non-compliant shell around the heart, and resulting from chronic inflammation of the pericardium.\nsynonyms :\n'}


{'id': 'HP_0002564', 'url': 'http://purl.obolibrary.org/obo/HP_0002564', 'lbl': 'obsolete Malformation of the heart and great vessels', 'desc': 'label: obsolete Malformation of the heart and great vessels\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002566', 'url': 'http://purl.obolibrary.org/obo/HP_0002566', 'lbl': 'Intestinal malrotation', 'desc': 'label: Intestinal malrotation\ndefinition : An abnormality of the intestinal rotation and fixation that normally occurs during the development of the gut. This can lead to volvulus, or twisting of the intestine that causes obstruction and necrosis.\nsynonyms :Malrotation; Gut malrotation\n'}


{'id': 'HP_0002570', 'url': 'http://purl.obolibrary.org/obo/HP_0002570', 'lbl': 'Steatorrhea', 'desc': 'label: Steatorrhea\ndefinition : Greater than normal amounts of fat in the feces. This is a result of malabsorption of lipids in the small intestine and results in frothy foul-smelling fecal matter that floats.\nsynonyms :Fat in faeces; Fat in feces; Fatty stool; Greasy stools\n'}


{'id': 'HP_0002571', 'url': 'http://purl.obolibrary.org/obo/HP_0002571', 'lbl': 'Achalasia', 'desc': 'label: Achalasia\ndefinition : A disorder of esophageal motility characterized by the inability of the lower esophageal sphincter to relax during swallowing and by inadequate or lacking peristalsis in the lower half of the body of the esophagus.\nsynonyms :Achalasia of the esophagus; Achalasia of the oesophagus\n'}


{'id': 'HP_0002572', 'url': 'http://purl.obolibrary.org/obo/HP_0002572', 'lbl': 'Episodic vomiting', 'desc': 'label: Episodic vomiting\ndefinition : Paroxysmal, recurrent episodes of vomiting.\nsynonyms :Episodic vomiting; Frequent vomiting\n'}


{'id': 'HP_0002573', 'url': 'http://purl.obolibrary.org/obo/HP_0002573', 'lbl': 'Hematochezia', 'desc': 'label: Hematochezia\ndefinition : The passage of fresh (red) blood per anus, usually in or with stools. Most rectal bleeding comes from the colon, rectum, or anus.\nsynonyms :Rectal bleeding; Recurrent rectal bleeding\n'}


{'id': 'HP_0002574', 'url': 'http://purl.obolibrary.org/obo/HP_0002574', 'lbl': 'Episodic abdominal pain', 'desc': 'label: Episodic abdominal pain\ndefinition : An intermittent form of abdominal pain.\nsynonyms :Intermittent abdominal pain\n'}


{'id': 'HP_0002575', 'url': 'http://purl.obolibrary.org/obo/HP_0002575', 'lbl': 'Tracheoesophageal fistula', 'desc': 'label: Tracheoesophageal fistula\ndefinition : An abnormal connection (fistula) between the esophagus and the trachea.\nsynonyms :Abnormal connection between trachea and esophagus; Abnormal connection between trachea and oesophagus\n'}


{'id': 'HP_0002576', 'url': 'http://purl.obolibrary.org/obo/HP_0002576', 'lbl': 'Intussusception', 'desc': 'label: Intussusception\ndefinition : An abnormality of the intestine in which part of the intestine invaginates (telescopes) into another part of the intestine.\nsynonyms :\n'}


{'id': 'HP_0002577', 'url': 'http://purl.obolibrary.org/obo/HP_0002577', 'lbl': 'Abnormal stomach morphology', 'desc': 'label: Abnormal stomach morphology\ndefinition : An abnormality of the stomach.\nsynonyms :Abnormality of the stomach\n'}


{'id': 'HP_0002578', 'url': 'http://purl.obolibrary.org/obo/HP_0002578', 'lbl': 'Gastroparesis', 'desc': 'label: Gastroparesis\ndefinition : Decreased strength of the muscle layer of stomach, which leads to a decreased ability to empty the contents of the stomach despite the absence of obstruction.\nsynonyms :Delayed gastric emptying\n'}


{'id': 'HP_0002579', 'url': 'http://purl.obolibrary.org/obo/HP_0002579', 'lbl': 'Gastrointestinal dysmotility', 'desc': 'label: Gastrointestinal dysmotility\ndefinition : Abnormal intestinal contractions, such as spasms and intestinal paralysis, related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes.\nsynonyms :GI dysmotility\n'}


{'id': 'HP_0002580', 'url': 'http://purl.obolibrary.org/obo/HP_0002580', 'lbl': 'Volvulus', 'desc': 'label: Volvulus\ndefinition : Abnormal twisting of a portion of intestine around itself or around a stalk of mesentery tissue.\nsynonyms :\n'}


{'id': 'HP_0002582', 'url': 'http://purl.obolibrary.org/obo/HP_0002582', 'lbl': 'Atrophic gastritis', 'desc': 'label: Atrophic gastritis\ndefinition : Atrophic gastritis (AG) is a histopathological entity that is characterized by chronic inflammation of the gastric mucosa with loss of gastric glandular cells and replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue.\nsynonyms :Chronic atrophic gastritis\n'}


{'id': 'HP_0002583', 'url': 'http://purl.obolibrary.org/obo/HP_0002583', 'lbl': 'Colitis', 'desc': 'label: Colitis\ndefinition : Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine (colon, cecum and rectum). Colitides may be acute and self-limited or chronic, and broadly fit into the category of digestive diseases.\nsynonyms :\n'}


{'id': 'HP_0002584', 'url': 'http://purl.obolibrary.org/obo/HP_0002584', 'lbl': 'Intestinal bleeding', 'desc': 'label: Intestinal bleeding\ndefinition : Bleeding from the intestines.\nsynonyms :Intestinal bleeding; Intestinal haemorrhage; Intestinal hemorrhage\n'}


{'id': 'HP_0002585', 'url': 'http://purl.obolibrary.org/obo/HP_0002585', 'lbl': 'Abnormality of the peritoneum', 'desc': 'label: Abnormality of the peritoneum\ndefinition : An abnormality of the peritoneum.\nsynonyms :\n'}


{'id': 'HP_0002586', 'url': 'http://purl.obolibrary.org/obo/HP_0002586', 'lbl': 'Peritonitis', 'desc': 'label: Peritonitis\ndefinition : Inflammation of the peritoneum.\nsynonyms :Inflammation of the peritoneum\n'}


{'id': 'HP_0002587', 'url': 'http://purl.obolibrary.org/obo/HP_0002587', 'lbl': 'Projectile vomiting', 'desc': 'label: Projectile vomiting\ndefinition : Vomiting that ejects the gastric contents with great force.\nsynonyms :Projectile vomiting\n'}


{'id': 'HP_0002588', 'url': 'http://purl.obolibrary.org/obo/HP_0002588', 'lbl': 'Duodenal ulcer', 'desc': 'label: Duodenal ulcer\ndefinition : An erosion of the mucous membrane in a portion of the duodenum.\nsynonyms :\n'}


{'id': 'HP_0002589', 'url': 'http://purl.obolibrary.org/obo/HP_0002589', 'lbl': 'Gastrointestinal atresia', 'desc': 'label: Gastrointestinal atresia\ndefinition : \nsynonyms :GI atresia\n'}


{'id': 'HP_0002590', 'url': 'http://purl.obolibrary.org/obo/HP_0002590', 'lbl': 'Paralytic ileus', 'desc': 'label: Paralytic ileus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002591', 'url': 'http://purl.obolibrary.org/obo/HP_0002591', 'lbl': 'Polyphagia', 'desc': 'label: Polyphagia\ndefinition : A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat.\nsynonyms :Hyperphagia; Voracious appetite; Increased appetite\n'}


{'id': 'HP_0002592', 'url': 'http://purl.obolibrary.org/obo/HP_0002592', 'lbl': 'Gastric ulcer', 'desc': 'label: Gastric ulcer\ndefinition : An ulcer, that is, an erosion of an area of the gastric mucous membrane.\nsynonyms :Stomach ulcer\n'}


{'id': 'HP_0002593', 'url': 'http://purl.obolibrary.org/obo/HP_0002593', 'lbl': 'Intestinal lymphangiectasia', 'desc': 'label: Intestinal lymphangiectasia\ndefinition : Angiectasia of lymph vessels (i.e., dilatation of lymphatic vessels) in the intestines.\nsynonyms :\n'}


{'id': 'HP_0002594', 'url': 'http://purl.obolibrary.org/obo/HP_0002594', 'lbl': 'Pancreatic hypoplasia', 'desc': 'label: Pancreatic hypoplasia\ndefinition : Hypoplasia of the pancreas.\nsynonyms :Hypoplastic pancreas; Underdeveloped pancreas\n'}


{'id': 'HP_0002595', 'url': 'http://purl.obolibrary.org/obo/HP_0002595', 'lbl': 'Ileus', 'desc': 'label: Ileus\ndefinition : Acute obstruction of the intestines preventing passage of the contents of the intestines.\nsynonyms :Gastrointestinal atony\n'}


{'id': 'HP_0002597', 'url': 'http://purl.obolibrary.org/obo/HP_0002597', 'lbl': 'Abnormality of the vasculature', 'desc': 'label: Abnormality of the vasculature\ndefinition : An abnormality of the vasculature.\nsynonyms :Abnormality of blood vessels; Abnormality of the vasculature; Vascular abnormalities\n'}


{'id': 'HP_0002599', 'url': 'http://purl.obolibrary.org/obo/HP_0002599', 'lbl': 'Head titubation', 'desc': 'label: Head titubation\ndefinition : A head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction.\nsynonyms :\n'}


{'id': 'HP_0002600', 'url': 'http://purl.obolibrary.org/obo/HP_0002600', 'lbl': 'Hyporeflexia of lower limbs', 'desc': 'label: Hyporeflexia of lower limbs\ndefinition : Reduced intensity of muscle tendon reflexes in the lower limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping.\nsynonyms :Hyporeflexia in lower limbs; Hyporeflexia of the lower limbs; Hyporeflexia, lower limbs; Hyporeflexia/areflexia in lower limbs\n'}


{'id': 'HP_0002601', 'url': 'http://purl.obolibrary.org/obo/HP_0002601', 'lbl': 'Paresis of extensor muscles of the big toe', 'desc': 'label: Paresis of extensor muscles of the big toe\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002604', 'url': 'http://purl.obolibrary.org/obo/HP_0002604', 'lbl': 'Gastrointestinal telangiectasia', 'desc': 'label: Gastrointestinal telangiectasia\ndefinition : Telangiectasia affecting the gastrointestinal tract.\nsynonyms :GI telangiectasia; Small, enlarged blood vessels near skin\n'}


{'id': 'HP_0002605', 'url': 'http://purl.obolibrary.org/obo/HP_0002605', 'lbl': 'Hepatic necrosis', 'desc': 'label: Hepatic necrosis\ndefinition : The presence of cell death (necrosis) affecting the liver.\nsynonyms :\n'}


{'id': 'HP_0002607', 'url': 'http://purl.obolibrary.org/obo/HP_0002607', 'lbl': 'Bowel incontinence', 'desc': 'label: Bowel incontinence\ndefinition : Involuntary fecal soiling in adults and children who have usually already been toilet trained.\nsynonyms :Anal incontinence; Faecal incontinence; Fecal incontinence; Loss of bowel control\n'}


{'id': 'HP_0002608', 'url': 'http://purl.obolibrary.org/obo/HP_0002608', 'lbl': 'Celiac disease', 'desc': 'label: Celiac disease\ndefinition : Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. Clinical manifestations of CD are highly variable and include both gastrointestinal and non-gastrointestinal features. The hallmark of CD is an immune-mediated enteropathy. This term is included because the occurence of CD is seen as a feature of a number of other diseases.\nsynonyms :Celiac disease; Celiac sprue; Coeliac disease; Coeliac sprue\n'}


{'id': 'HP_0002611', 'url': 'http://purl.obolibrary.org/obo/HP_0002611', 'lbl': 'Cholestatic liver disease', 'desc': 'label: Cholestatic liver disease\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002612', 'url': 'http://purl.obolibrary.org/obo/HP_0002612', 'lbl': 'Congenital hepatic fibrosis', 'desc': 'label: Congenital hepatic fibrosis\ndefinition : The presence of fibrosis of that part of the liver with congenital onset.\nsynonyms :Congenital liver fibrosis; Excessive buildup of connective tissue and scarring of liver at birth\n'}


{'id': 'HP_0002613', 'url': 'http://purl.obolibrary.org/obo/HP_0002613', 'lbl': 'Biliary cirrhosis', 'desc': 'label: Biliary cirrhosis\ndefinition : Progressive destruction of the small-to-medium bile ducts of the intrahepatic biliary tree, which leads to progressive cholestasis and often end-stage liver disease.\nsynonyms :Primary biliary cirrhosis\n'}


{'id': 'HP_0002614', 'url': 'http://purl.obolibrary.org/obo/HP_0002614', 'lbl': 'Hepatic periportal necrosis', 'desc': 'label: Hepatic periportal necrosis\ndefinition : A type of hepatic necrosis that is concentrated around the necrosis of hepatocytes localized around the intrahepatic branch of portal vein.\nsynonyms :\n'}


{'id': 'HP_0002615', 'url': 'http://purl.obolibrary.org/obo/HP_0002615', 'lbl': 'Hypotension', 'desc': 'label: Hypotension\ndefinition : Low Blood Pressure, vascular hypotension.\nsynonyms :Arterial hypotension; Low blood pressure\n'}


{'id': 'HP_0002616', 'url': 'http://purl.obolibrary.org/obo/HP_0002616', 'lbl': 'Aortic root aneurysm', 'desc': 'label: Aortic root aneurysm\ndefinition : An abnormal localized widening (dilatation) of the aortic root.\nsynonyms :Aortic root dilatation; Bulge in wall of root of large artery that carries blood away from heart; Increased aortic root diameter\n'}


{'id': 'HP_0002617', 'url': 'http://purl.obolibrary.org/obo/HP_0002617', 'lbl': 'Vascular dilatation', 'desc': 'label: Vascular dilatation\ndefinition : Abnormal outpouching or sac-like dilatation in the wall of an atery, vein or the heart.\nsynonyms :Aneurysmal dilatation; Wider than typical opening or gap; Aneurysm; Aneurysms; Aneurysmal disease\n'}


{'id': 'HP_0002619', 'url': 'http://purl.obolibrary.org/obo/HP_0002619', 'lbl': 'Varicose veins', 'desc': 'label: Varicose veins\ndefinition : Enlarged and tortuous veins.\nsynonyms :\n'}


{'id': 'HP_0002621', 'url': 'http://purl.obolibrary.org/obo/HP_0002621', 'lbl': 'Atherosclerosis', 'desc': 'label: Atherosclerosis\ndefinition : A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow.\nsynonyms :Plaque build-up in arteries; Atherosclerotic cardiovascular disease; Narrowing and hardening of arteries\n'}


{'id': 'HP_0002622', 'url': 'http://purl.obolibrary.org/obo/HP_0002622', 'lbl': 'obsolete Dissecting aortic dilatation', 'desc': 'label: obsolete Dissecting aortic dilatation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002623', 'url': 'http://purl.obolibrary.org/obo/HP_0002623', 'lbl': 'Overriding aorta', 'desc': 'label: Overriding aorta\ndefinition : An overriding aorta is a congenital heart defect where the aorta is positioned directly over a ventricular septal defect, instead of over the left ventricle. The result is that the aorta receives some blood from the right ventricle, which reduces the amount of oxygen in the blood. It is one of the four conditions of the Tetralogy of Fallot. The aortic root can be displaced toward the front (anteriorly) or directly above the septal defect, but it is always abnormally located to the right of the root of the pulmonary artery. The degree of override is quite variable, with 5-95% of the valve being connected to the right ventricle.\nsynonyms :Dextroposition of aorta; Overriding aortic valve\n'}


{'id': 'HP_0002624', 'url': 'http://purl.obolibrary.org/obo/HP_0002624', 'lbl': 'Abnormal venous morphology', 'desc': 'label: Abnormal venous morphology\ndefinition : An anomaly of vein.\nsynonyms :Abnormal vein; Venous abnormality\n'}


{'id': 'HP_0002625', 'url': 'http://purl.obolibrary.org/obo/HP_0002625', 'lbl': 'Deep venous thrombosis', 'desc': 'label: Deep venous thrombosis\ndefinition : Formation of a blot clot in a deep vein. The clot often blocks blood flow, causing swelling and pain. The deep veins of the leg are most often affected.\nsynonyms :Blood clot in a deep vein; Deep vein thrombosis; Multiple deep venous thrombosis\n'}


{'id': 'HP_0002626', 'url': 'http://purl.obolibrary.org/obo/HP_0002626', 'lbl': 'Venous varicosities of celiac and mesenteric vessels', 'desc': 'label: Venous varicosities of celiac and mesenteric vessels\ndefinition : Elongated and tortuous mesenteric veins, which comprise the inferior mesenteric vein and the superior mesenteric vein.\nsynonyms :Venous varicosities of coeliac and mesenteric vessels\n'}


{'id': 'HP_0002627', 'url': 'http://purl.obolibrary.org/obo/HP_0002627', 'lbl': 'Right aortic arch with mirror image branching', 'desc': 'label: Right aortic arch with mirror image branching\ndefinition : The aortic arch crosses the right mainstem bronchus and not the left mainstem bronchus, but does not result in the creation of a vascular ring. The first branch is the left brachiocephalic artery which divides into the left carotid artery and left subclavian artery, the second branch is the right carotid artery, the third branch is the right subclavian artery.\nsynonyms :\n'}


{'id': 'HP_0002629', 'url': 'http://purl.obolibrary.org/obo/HP_0002629', 'lbl': 'Gastrointestinal arteriovenous malformation', 'desc': 'label: Gastrointestinal arteriovenous malformation\ndefinition : An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the gastrointestinal tract.\nsynonyms :GI arteriovenous malformation\n'}


{'id': 'HP_0002630', 'url': 'http://purl.obolibrary.org/obo/HP_0002630', 'lbl': 'Fat malabsorption', 'desc': 'label: Fat malabsorption\ndefinition : Abnormality of the absorption of fat from the gastrointestinal tract.\nsynonyms :\n'}


{'id': 'HP_0002631', 'url': 'http://purl.obolibrary.org/obo/HP_0002631', 'lbl': 'obsolete Dilatation of ascending aorta', 'desc': 'label: obsolete Dilatation of ascending aorta\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002632', 'url': 'http://purl.obolibrary.org/obo/HP_0002632', 'lbl': 'Low-to-normal blood pressure', 'desc': 'label: Low-to-normal blood pressure\ndefinition : \nsynonyms :Low-to-normal BP; Low-to-normal blood pressure\n'}


{'id': 'HP_0002633', 'url': 'http://purl.obolibrary.org/obo/HP_0002633', 'lbl': 'Vasculitis', 'desc': 'label: Vasculitis\ndefinition : Inflammation of blood vessel.\nsynonyms :Angiitis; Inflammation of blood vessel\n'}


{'id': 'HP_0002634', 'url': 'http://purl.obolibrary.org/obo/HP_0002634', 'lbl': 'Arteriosclerosis', 'desc': 'label: Arteriosclerosis\ndefinition : Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity.\nsynonyms :Hardened artery wall\n'}


{'id': 'HP_0002635', 'url': 'http://purl.obolibrary.org/obo/HP_0002635', 'lbl': 'Type IV atherosclerotic lesion', 'desc': 'label: Type IV atherosclerotic lesion\ndefinition : In type IV atherosclerotic lesions a dense accumulation of extracellular lipid occupies an extensive but well-defined region of the intima. This type of extracellular lipid accumulation is known as the lipid core. A fibrous tissue increase is not a feature, and complications such as defects of the lesion surface and thrombosis are not present. The type IV lesion is also known as atheroma. Type IV is the first lesion considered advanced in this classification because of the severe intimal disorganization caused by the lipid core. The characteristic core appears to develop from an increase and the consequent confluence of the small isolated pools of extracellular lipid that characterize type III lesions. The increase in lipid is believed to result from continued insudation from the plasma. Type IV lesions, when they first appear in younger people, are found in the same locations as adaptive intimal thickenings of the eccentric type. Thus, atheroma is, at least initially, an eccentric lesion.\nsynonyms :Atheromatosis\n'}


{'id': 'HP_0002636', 'url': 'http://purl.obolibrary.org/obo/HP_0002636', 'lbl': 'Dilatation of an abdominal artery', 'desc': 'label: Dilatation of an abdominal artery\ndefinition : Abnormal outpouching or sac-like dilatation in an artery that originates from the abdominal aorta.\nsynonyms :Aneurysm of an abdominal artery\n'}


{'id': 'HP_0002637', 'url': 'http://purl.obolibrary.org/obo/HP_0002637', 'lbl': 'Cerebral ischemia', 'desc': 'label: Cerebral ischemia\ndefinition : Restriction of arterial blood supply to the brain associated with insufficient oxygenation to support the metabolic requirements of the tissue.\nsynonyms :Brain ischemia; Cerebrovascular ischemia; Disruption of blood oxygen supply to brain\n'}


{'id': 'HP_0002638', 'url': 'http://purl.obolibrary.org/obo/HP_0002638', 'lbl': 'Superficial thrombophlebitis', 'desc': 'label: Superficial thrombophlebitis\ndefinition : Inflammation of a superficial vein associated with venous thrombosis (blood clot formation within the vein).\nsynonyms :\n'}


{'id': 'HP_0002639', 'url': 'http://purl.obolibrary.org/obo/HP_0002639', 'lbl': 'Budd-Chiari syndrome', 'desc': 'label: Budd-Chiari syndrome\ndefinition : Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow at any level from the small hepatic veins to the junction of the inferior vena cava (IVC) with the right atrium, 1 and occurs in 1/100,000 of the general population worldwide. The most common presentation is with ascites, but can range from fulminant hepatic failure (FHF) to asymptomatic forms. Obstruction of hepatic venous outflow is mainly caused by primary intravascular thrombosis, which can occur suddenly or be repeated over time, accompanied by some revascularization, accounting for the variable parenchymal hepatic damage and histologic presentation. Budd-Chiari syndrome is thus a disease, but since it occurs as a manifestation of several other diseases, this term is kept for the present for convenience.\nsynonyms :\n'}


{'id': 'HP_0002640', 'url': 'http://purl.obolibrary.org/obo/HP_0002640', 'lbl': 'Hypertension associated with pheochromocytoma', 'desc': 'label: Hypertension associated with pheochromocytoma\ndefinition : A type of hypertension associated with pheochromocytoma.\nsynonyms :\n'}


{'id': 'HP_0002641', 'url': 'http://purl.obolibrary.org/obo/HP_0002641', 'lbl': 'Peripheral thrombosis', 'desc': 'label: Peripheral thrombosis\ndefinition : \nsynonyms :Peripheral blood clot\n'}


{'id': 'HP_0002642', 'url': 'http://purl.obolibrary.org/obo/HP_0002642', 'lbl': 'Arteriovenous fistulas of celiac and mesenteric vessels', 'desc': 'label: Arteriovenous fistulas of celiac and mesenteric vessels\ndefinition : \nsynonyms :Arteriovenous fistulas of coeliac and mesenteric vessels\n'}


{'id': 'HP_0002643', 'url': 'http://purl.obolibrary.org/obo/HP_0002643', 'lbl': 'Neonatal respiratory distress', 'desc': 'label: Neonatal respiratory distress\ndefinition : Respiratory difficulty as newborn.\nsynonyms :Infantile respiratory distress; Neonatal respiratory distress; Newborn respiratory distress; Respiratory distress, neonatal\n'}


{'id': 'HP_0002644', 'url': 'http://purl.obolibrary.org/obo/HP_0002644', 'lbl': 'Abnormal pelvic girdle bone morphology', 'desc': 'label: Abnormal pelvic girdle bone morphology\ndefinition : An abnormality of the bony pelvic girdle, which is a ring of bones connecting the vertebral column to the femurs.\nsynonyms :Abnormal shape of pelvic girdle bone; Abnormality of pelvic girdle bone morphology; Abnormality of the pelvic girdle\n'}


{'id': 'HP_0002645', 'url': 'http://purl.obolibrary.org/obo/HP_0002645', 'lbl': 'Wormian bones', 'desc': 'label: Wormian bones\ndefinition : The presence of extra bones within a cranial suture. Wormian bones are irregular isolated bones which appear in addition to the usual centers of ossification of the cranium.\nsynonyms :Extra bones within cranial sutures; Intra sutural bones; Intrasutural bones; Islands of bone within cranial sutures\n'}


{'id': 'HP_0002647', 'url': 'http://purl.obolibrary.org/obo/HP_0002647', 'lbl': 'Aortic dissection', 'desc': 'label: Aortic dissection\ndefinition : Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta.\nsynonyms :Tear in inner wall of large artery that carries blood away from heart\n'}


{'id': 'HP_0002648', 'url': 'http://purl.obolibrary.org/obo/HP_0002648', 'lbl': 'obsolete Abnormality of calvarial morphology', 'desc': 'label: obsolete Abnormality of calvarial morphology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002650', 'url': 'http://purl.obolibrary.org/obo/HP_0002650', 'lbl': 'Scoliosis', 'desc': 'label: Scoliosis\ndefinition : The presence of an abnormal lateral curvature of the spine.\nsynonyms :\n'}


{'id': 'HP_0002651', 'url': 'http://purl.obolibrary.org/obo/HP_0002651', 'lbl': 'Spondyloepimetaphyseal dysplasia', 'desc': 'label: Spondyloepimetaphyseal dysplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002652', 'url': 'http://purl.obolibrary.org/obo/HP_0002652', 'lbl': 'Skeletal dysplasia', 'desc': 'label: Skeletal dysplasia\ndefinition : A general term describing features characterized by abnormal development of bones and connective tissues.\nsynonyms :Abnormal skeletal development\n'}


{'id': 'HP_0002653', 'url': 'http://purl.obolibrary.org/obo/HP_0002653', 'lbl': 'Bone pain', 'desc': 'label: Bone pain\ndefinition : An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.\nsynonyms :Bone pain\n'}


{'id': 'HP_0002654', 'url': 'http://purl.obolibrary.org/obo/HP_0002654', 'lbl': 'Multiple epiphyseal dysplasia', 'desc': 'label: Multiple epiphyseal dysplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002655', 'url': 'http://purl.obolibrary.org/obo/HP_0002655', 'lbl': 'Spondyloepiphyseal dysplasia', 'desc': 'label: Spondyloepiphyseal dysplasia\ndefinition : A disorder of bone growth affecting the vertebrae and the ends of the long bones (epiphyses).\nsynonyms :Spondyloepiphyseal dysplasia tarda\n'}


{'id': 'HP_0002656', 'url': 'http://purl.obolibrary.org/obo/HP_0002656', 'lbl': 'Epiphyseal dysplasia', 'desc': 'label: Epiphyseal dysplasia\ndefinition : \nsynonyms :Abnormal development of end part of bone; Abnormal development of the ends of long bones in arms and legs\n'}


{'id': 'HP_0002657', 'url': 'http://purl.obolibrary.org/obo/HP_0002657', 'lbl': 'Spondylometaphyseal dysplasia', 'desc': 'label: Spondylometaphyseal dysplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002659', 'url': 'http://purl.obolibrary.org/obo/HP_0002659', 'lbl': 'Increased susceptibility to fractures', 'desc': 'label: Increased susceptibility to fractures\ndefinition : An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture.\nsynonyms :Abnormal susceptibility to fractures; Bone fragility; Frequent broken bones; Increased bone fragility; Increased susceptibility to fractures; Increased tendency to fractures\n'}


{'id': 'HP_0002661', 'url': 'http://purl.obolibrary.org/obo/HP_0002661', 'lbl': 'Painless fractures due to injury', 'desc': 'label: Painless fractures due to injury\ndefinition : An increased tendency to fractures following trauma, with fractures occurring without pain.\nsynonyms :Painless fractures due to injury\n'}


{'id': 'HP_0002663', 'url': 'http://purl.obolibrary.org/obo/HP_0002663', 'lbl': 'Delayed epiphyseal ossification', 'desc': 'label: Delayed epiphyseal ossification\ndefinition : \nsynonyms :Delayed epiphyseal maturation; Delayed opacification of the epiphyses; Epiphyseal ossification delay; Delayed maturation of end part of long bone\n'}


{'id': 'HP_0002664', 'url': 'http://purl.obolibrary.org/obo/HP_0002664', 'lbl': 'Neoplasm', 'desc': 'label: Neoplasm\ndefinition : An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).\nsynonyms :Abnormal tissue mass; Neoplasia; Oncological abnormality; Tumor; Tumour; Cancer; Oncology\n'}


{'id': 'HP_0002665', 'url': 'http://purl.obolibrary.org/obo/HP_0002665', 'lbl': 'Lymphoma', 'desc': 'label: Lymphoma\ndefinition : A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells.\nsynonyms :Cancer of lymphatic system\n'}


{'id': 'HP_0002666', 'url': 'http://purl.obolibrary.org/obo/HP_0002666', 'lbl': 'Pheochromocytoma', 'desc': 'label: Pheochromocytoma\ndefinition : Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines.\nsynonyms :Chromaffin tumors; Chromaffin tumours\n'}


{'id': 'HP_0002667', 'url': 'http://purl.obolibrary.org/obo/HP_0002667', 'lbl': 'Nephroblastoma', 'desc': 'label: Nephroblastoma\ndefinition : The presence of a nephroblastoma, which is a neoplasm of the kidney that primarily affects children.\nsynonyms :Wilms tumor; Wilms tumour\n'}


{'id': 'HP_0002668', 'url': 'http://purl.obolibrary.org/obo/HP_0002668', 'lbl': 'Paraganglioma', 'desc': 'label: Paraganglioma\ndefinition : A carotid body tumor (also called paraganglionoma or chemodectoma) is a tumor found in the upper neck at the branching of the carotid artery. They arise from the chemoreceptor organ (paraganglion) located in the adventitia of the carotid artery bifurcation.\nsynonyms :Carotid body tumors; Carotid body tumours; Paragangliomas\n'}


{'id': 'HP_0002669', 'url': 'http://purl.obolibrary.org/obo/HP_0002669', 'lbl': 'Osteosarcoma', 'desc': 'label: Osteosarcoma\ndefinition : A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.\nsynonyms :Bone cell cancer; Osteogenic sarcoma\n'}


{'id': 'HP_0002671', 'url': 'http://purl.obolibrary.org/obo/HP_0002671', 'lbl': 'Basal cell carcinoma', 'desc': 'label: Basal cell carcinoma\ndefinition : The presence of a basal cell carcinoma of the skin.\nsynonyms :Basal cell carcinomas; Basal cell epithelioma; Basal cell nevus; Basalioma\n'}


{'id': 'HP_0002672', 'url': 'http://purl.obolibrary.org/obo/HP_0002672', 'lbl': 'Gastrointestinal carcinoma', 'desc': 'label: Gastrointestinal carcinoma\ndefinition : \nsynonyms :GI carcinoma\n'}


{'id': 'HP_0002673', 'url': 'http://purl.obolibrary.org/obo/HP_0002673', 'lbl': 'Coxa valga', 'desc': 'label: Coxa valga\ndefinition : Coxa valga is a deformity of the hip in which the angle between the femoral shaft and the femoral neck is increased compared to age-adjusted values (about 150 degrees in newborns gradually reducing to 120-130 degrees in adults).\nsynonyms :Valgus hip; Coxa valga deformity\n'}


{'id': 'HP_0002676', 'url': 'http://purl.obolibrary.org/obo/HP_0002676', 'lbl': 'Cloverleaf skull', 'desc': 'label: Cloverleaf skull\ndefinition : Trilobar skull configuration when viewed from the front or behind.\nsynonyms :Cloverleaf cranium shape; Cloverleaf skull shape; Trilobar cranium shape; Trilobar skull shape; Kleeblattschaedel\n'}


{'id': 'HP_0002677', 'url': 'http://purl.obolibrary.org/obo/HP_0002677', 'lbl': 'Small foramen magnum', 'desc': 'label: Small foramen magnum\ndefinition : An abnormal narrowing of the foramen magnum.\nsynonyms :Foramen magnum stenosis; Little foramen magnum; Narrow foramen magnum; Hypoplasia of foramen magnum; Stenosis of foramen magnum\n'}


{'id': 'HP_0002678', 'url': 'http://purl.obolibrary.org/obo/HP_0002678', 'lbl': 'Skull asymmetry', 'desc': 'label: Skull asymmetry\ndefinition : \nsynonyms :Abnormality of skull shape; Unequal skull shape; Uneven skull shape; Asymmetry of skull; Skull asymmetry; Malformation of skull shape\n'}


{'id': 'HP_0002679', 'url': 'http://purl.obolibrary.org/obo/HP_0002679', 'lbl': 'Abnormal sella turcica morphology', 'desc': 'label: Abnormal sella turcica morphology\ndefinition : Abnormality of the sella turcica, a saddle-shaped depression in the sphenoid bone at the base of the human skull.\nsynonyms :Abnormality of the sella turcica; Anomaly of the sella turcica; Abnormality of the hypophysial fossa; Abnormality of the pituitary fossa; Anomaly of the hypophysial fossa; Anomaly of the pituitary fossa\n'}


{'id': 'HP_0002680', 'url': 'http://purl.obolibrary.org/obo/HP_0002680', 'lbl': 'J-shaped sella turcica', 'desc': 'label: J-shaped sella turcica\ndefinition : A deformity of the sella turcica whereby the sella extends further anterior than normal such that the anterior clinoid process appears to overhang it, giving the appearance of the letter J on imaging of the skull.\nsynonyms :Hour glass shaped hypophysial fossa; Hour glass shaped pituitary fossa; Hour glass shaped sella turcica; J-shaped sella; Omega shaped sella turcica; J-shaped hypophysial fossa; J-shaped pituitary fossa; Omega shaped hypophysial fossa; Omega shaped pituitary fossa\n'}


{'id': 'HP_0002681', 'url': 'http://purl.obolibrary.org/obo/HP_0002681', 'lbl': 'Deformed sella turcica', 'desc': 'label: Deformed sella turcica\ndefinition : \nsynonyms :Abnormal shape of hypophysial fossa; Abnormal shape of pituitary fossa; Abnormal shape of sella turcica; Deformity of hypophysial fossa; Deformity of pituitary fossa; Malformation of hypophysial fossa; Malformation of pituitary fossa; Malformation of sella turcica\n'}


{'id': 'HP_0002682', 'url': 'http://purl.obolibrary.org/obo/HP_0002682', 'lbl': 'Broad skull', 'desc': 'label: Broad skull\ndefinition : Increased width of the skull.\nsynonyms :Broad cranium; Broad skull; Increased width of cranium; Increased width of skull; Wide cranium; Wide skull\n'}


{'id': 'HP_0002683', 'url': 'http://purl.obolibrary.org/obo/HP_0002683', 'lbl': 'Abnormal calvaria morphology', 'desc': 'label: Abnormal calvaria morphology\ndefinition : Abnormality of the morphology (structure) of the calvaria (skullcap), that is, of that part of the skull that is made up of the superior portions of the frontal bone, occipital bone, and parietal bones and covers the cranial cavity that contains the brain.\nsynonyms :Abnormality of cranium; Abnormality of calvarium; Abnormality of cranial vault; Abnormality of the calvaria; Abnormality of the shape of calvarium; Abnormality of the skull cap; Abnormality of the skullcap\n'}


{'id': 'HP_0002684', 'url': 'http://purl.obolibrary.org/obo/HP_0002684', 'lbl': 'Thickened calvaria', 'desc': 'label: Thickened calvaria\ndefinition : The presence of an abnormally thick calvaria.\nsynonyms :Increased thickness of cranium; Calvarial thickening; Calvarium thickened; Increased calvarial thickness; Increased thickness of calvaria; Increased thickness of calvarium; Increased thickness of cranial vault; Increased thickness of skull cap; Thick calvaria; Thick calvarium; Thickened calvarium; Thickened cranial vault; Thickened cranium; Thickened skull cap; Thickening of the calvaria\n'}


{'id': 'HP_0002686', 'url': 'http://purl.obolibrary.org/obo/HP_0002686', 'lbl': 'Pregnancy history', 'desc': 'label: Pregnancy history\ndefinition : Medical history of maternal diseases, exposures, or other relevant findings during the pregnancy of which the index person was the product.\nsynonyms :Prenatal maternal abnormality; Maternal health problem\n'}


{'id': 'HP_0002687', 'url': 'http://purl.obolibrary.org/obo/HP_0002687', 'lbl': 'Abnormality of frontal sinus', 'desc': 'label: Abnormality of frontal sinus\ndefinition : An abnormality of the frontal sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The frontal sinus is located within the frontal bone.\nsynonyms :Abnormality of sinus frontalis; Abnormality of the forehead sinus\n'}


{'id': 'HP_0002688', 'url': 'http://purl.obolibrary.org/obo/HP_0002688', 'lbl': 'Absent frontal sinuses', 'desc': 'label: Absent frontal sinuses\ndefinition : Aplasia of frontal sinus.\nsynonyms :Absence of frontal sinuses; Absent frontal sinus; Missing frontal sinus; Aplasia of frontal sinus; Aplasia sinus frontalis\n'}


{'id': 'HP_0002689', 'url': 'http://purl.obolibrary.org/obo/HP_0002689', 'lbl': 'Absent paranasal sinuses', 'desc': 'label: Absent paranasal sinuses\ndefinition : Aplasia of the paranasal sinuses.\nsynonyms :Missing sinuses; Absence of paranasal sinuses; Missing paranasal sinuses; Aplasia of paranasal sinuses\n'}


{'id': 'HP_0002690', 'url': 'http://purl.obolibrary.org/obo/HP_0002690', 'lbl': 'Large sella turcica', 'desc': 'label: Large sella turcica\ndefinition : An abnormal enlargement of the sella turcica.\nsynonyms :Big sella turcica; Enlarged sella turcica; Hyperplasia of sella turcica; Prominent sella turcica; Hyperplasia of hypophysial fossa; Hyperplasia of pituitary fossa; Large hypophysial fossa; Large pituitary fossa\n'}


{'id': 'HP_0002691', 'url': 'http://purl.obolibrary.org/obo/HP_0002691', 'lbl': 'Platybasia', 'desc': 'label: Platybasia\ndefinition : A developmental malformation of the occipital bone and upper end of the cervical spine, in which the latter appears to have pushed the floor of the occipital bone upward such that there is an abnormal flattening of the skull base.\nsynonyms :Flattening of the skull base; Increased basal angle of skull base; Obtuse basal angle of skull base\n'}