{'id': 'HP_0012352', 'url': 'http://purl.obolibrary.org/obo/HP_0012352', 'lbl': 'Abnormal fucosylation of protein N-linked glycosylation', 'desc': 'label: Abnormal fucosylation of protein N-linked glycosylation\ndefinition : An anomaly of the addition of fucose sugar units to N-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012353', 'url': 'http://purl.obolibrary.org/obo/HP_0012353', 'lbl': 'Decreased fucosylation of N-linked protein glycosylation', 'desc': 'label: Decreased fucosylation of N-linked protein glycosylation\ndefinition : Decreased addition of fucose sugar units to N-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012354', 'url': 'http://purl.obolibrary.org/obo/HP_0012354', 'lbl': 'Increased fucosylation of N-linked protein glycosylation', 'desc': 'label: Increased fucosylation of N-linked protein glycosylation\ndefinition : Increased addition of fucose sugar units to N-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012355', 'url': 'http://purl.obolibrary.org/obo/HP_0012355', 'lbl': 'Abnormal mannosylation of N-linked protein glycosylation', 'desc': 'label: Abnormal mannosylation of N-linked protein glycosylation\ndefinition : An anomaly of the addition of mannose to N-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012356', 'url': 'http://purl.obolibrary.org/obo/HP_0012356', 'lbl': 'Decreased mannosylation of N-linked protein glycosylation', 'desc': 'label: Decreased mannosylation of N-linked protein glycosylation\ndefinition : Reduced addition of mannose to N-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012357', 'url': 'http://purl.obolibrary.org/obo/HP_0012357', 'lbl': 'Increased mannosylation of N-linked protein glycosylation', 'desc': 'label: Increased mannosylation of N-linked protein glycosylation\ndefinition : Increased addition of mannose to N-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012358', 'url': 'http://purl.obolibrary.org/obo/HP_0012358', 'lbl': 'Abnormal protein O-linked glycosylation', 'desc': 'label: Abnormal protein O-linked glycosylation\ndefinition : An anomaly of protein O-linked glycosylation, i.e., of the process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of a serine or threonine residue.\nsynonyms :\n'}


{'id': 'HP_0012359', 'url': 'http://purl.obolibrary.org/obo/HP_0012359', 'lbl': 'Abnormal fucosylation of O-linked protein glycosylation', 'desc': 'label: Abnormal fucosylation of O-linked protein glycosylation\ndefinition : An anomaly of the addition of fucose sugar units to O-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012360', 'url': 'http://purl.obolibrary.org/obo/HP_0012360', 'lbl': 'Decreased fucosylation of O-linked protein glycosylation', 'desc': 'label: Decreased fucosylation of O-linked protein glycosylation\ndefinition : A reduction of the addition of fucose sugar units to O-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012361', 'url': 'http://purl.obolibrary.org/obo/HP_0012361', 'lbl': 'Increased fucosylation of O-linked protein glycosylation', 'desc': 'label: Increased fucosylation of O-linked protein glycosylation\ndefinition : Increased addition of fucose sugar units to O-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012362', 'url': 'http://purl.obolibrary.org/obo/HP_0012362', 'lbl': 'Abnormal sialylation of O-linked protein glycosylation', 'desc': 'label: Abnormal sialylation of O-linked protein glycosylation\ndefinition : An anomaly of the addition of sialic acids to O-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012363', 'url': 'http://purl.obolibrary.org/obo/HP_0012363', 'lbl': 'Decreased sialylation of O-linked protein glycosylation', 'desc': 'label: Decreased sialylation of O-linked protein glycosylation\ndefinition : An reduced addition of sialic acids to O-linked glycans.\nsynonyms :\n'}


{'id': 'HP_0012364', 'url': 'http://purl.obolibrary.org/obo/HP_0012364', 'lbl': 'Decreased urinary potassium', 'desc': 'label: Decreased urinary potassium\ndefinition : A decreased concentration of potassium(1+) in the urine.\nsynonyms :Decreased urinary K; Hypokaliuria; Hypokaluria; Low urine potassium levels\n'}


{'id': 'HP_0012365', 'url': 'http://purl.obolibrary.org/obo/HP_0012365', 'lbl': 'Hypophosphaturia', 'desc': 'label: Hypophosphaturia\ndefinition : An abnormally decreased phosphate concentration in the urine.\nsynonyms :Low urine phosphate levels\n'}


{'id': 'HP_0012366', 'url': 'http://purl.obolibrary.org/obo/HP_0012366', 'lbl': 'Basilar invagination', 'desc': "label: Basilar invagination\ndefinition : Projection of the tip of the dens more than 5 mm above a line joining the hard palate to the posterior lip of the foramen magnum (Chamberlain's line) or the tip of the dens is greater than 7 mm above McGregor's line (the back of the hard palate to the lowest point of the occipital squama).\nsynonyms :\n"}


{'id': 'HP_0012367', 'url': 'http://purl.obolibrary.org/obo/HP_0012367', 'lbl': 'Extra fontanelles', 'desc': 'label: Extra fontanelles\ndefinition : Bony defects situated along the cranial suture lines or at the junction of the bone plates of the skull.\nsynonyms :\n'}


{'id': 'HP_0012368', 'url': 'http://purl.obolibrary.org/obo/HP_0012368', 'lbl': 'Flat face', 'desc': 'label: Flat face\ndefinition : Absence of concavity or convexity of the face when viewed in profile.\nsynonyms :Flat face; Flat facial profile; Flat facial shape; Flat facies\n'}


{'id': 'HP_0012369', 'url': 'http://purl.obolibrary.org/obo/HP_0012369', 'lbl': 'obsolete Abnormal malar bone morphology', 'desc': 'label: obsolete Abnormal malar bone morphology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0012370', 'url': 'http://purl.obolibrary.org/obo/HP_0012370', 'lbl': 'Prominence of the zygomatic bone', 'desc': "label: Prominence of the zygomatic bone\ndefinition : Large or prominent malar surface of the zygomatic bone of the skull, which is convex and forms the prominence of the 'cheek bones'.\nsynonyms :Cheekbone excess; Zygomatic bone excess; Cheekbone prominence; Malar hypertrophy; Prominence of cheekbone; Pronounced cheekbone; Hyperplasia of cheekbone; Hyperplasia of zygomatic bone; Zygomatic hypertrophy\n"}


{'id': 'HP_0012371', 'url': 'http://purl.obolibrary.org/obo/HP_0012371', 'lbl': 'Hyperplasia of midface', 'desc': 'label: Hyperplasia of midface\ndefinition : Abnormally anterior positioning of the infraorbital and perialar regions, or increased convexity of the face, or increased nasolabial angle. The midface includes the maxilla, the cheeks, the zygomas, and the infraorbital and perialar regions of the face\nsynonyms :Big midface; Large midface; Midface hyperplasia; Midfacial excess; Midfacial prominence; Hypertrophy of midface; Overgrowth of the midface\n'}


{'id': 'HP_0012372', 'url': 'http://purl.obolibrary.org/obo/HP_0012372', 'lbl': 'Abnormal eye morphology', 'desc': 'label: Abnormal eye morphology\ndefinition : A structural anomaly of the globe of the eye, or bulbus oculi.\nsynonyms :Abnormal eye structure; Abnormality of the globe; Abnormally shaped eye\n'}


{'id': 'HP_0012373', 'url': 'http://purl.obolibrary.org/obo/HP_0012373', 'lbl': 'Abnormal eye physiology', 'desc': 'label: Abnormal eye physiology\ndefinition : A functional anomaly of the eye.\nsynonyms :Abnormal eye physiology\n'}


{'id': 'HP_0012374', 'url': 'http://purl.obolibrary.org/obo/HP_0012374', 'lbl': 'obsolete Abnormal globe morphology', 'desc': 'label: obsolete Abnormal globe morphology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0012375', 'url': 'http://purl.obolibrary.org/obo/HP_0012375', 'lbl': 'Chemosis', 'desc': 'label: Chemosis\ndefinition : Edema (swelling) of the bulbar conjunctiva.\nsynonyms :\n'}


{'id': 'HP_0012376', 'url': 'http://purl.obolibrary.org/obo/HP_0012376', 'lbl': 'Microphakia', 'desc': 'label: Microphakia\ndefinition : Abnormal smallness of the lens.\nsynonyms :Small lens\n'}


{'id': 'HP_0012377', 'url': 'http://purl.obolibrary.org/obo/HP_0012377', 'lbl': 'Hemianopia', 'desc': 'label: Hemianopia\ndefinition : Partial or complete loss of vision in one half of the visual field of one or both eyes.\nsynonyms :Hemianopsia\n'}


{'id': 'HP_0012378', 'url': 'http://purl.obolibrary.org/obo/HP_0012378', 'lbl': 'Fatigue', 'desc': 'label: Fatigue\ndefinition : A subjective feeling of tiredness characterized by a lack of energy and motivation.\nsynonyms :Fatigue; Tired; Tiredness\n'}


{'id': 'HP_0012379', 'url': 'http://purl.obolibrary.org/obo/HP_0012379', 'lbl': 'Abnormal circulating enzyme concentration or activity', 'desc': 'label: Abnormal circulating enzyme concentration or activity\ndefinition : Concentration or activity of an enzyme is above or below the limits of normal in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0012380', 'url': 'http://purl.obolibrary.org/obo/HP_0012380', 'lbl': 'Reduced carnitine O-palmitoyltransferase level', 'desc': 'label: Reduced carnitine O-palmitoyltransferase level\ndefinition : Reduced carnitine O-palmitoyltransferase level, leading to a reduced activity of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.\nsynonyms :\n'}


{'id': 'HP_0012381', 'url': 'http://purl.obolibrary.org/obo/HP_0012381', 'lbl': 'Delayed self-feeding during toddler years', 'desc': 'label: Delayed self-feeding during toddler years\ndefinition : A delay in the development of skills required to feed oneself in the toddler period (between one and three years of age).\nsynonyms :\n'}


{'id': 'HP_0012382', 'url': 'http://purl.obolibrary.org/obo/HP_0012382', 'lbl': 'Left-to-right shunt', 'desc': 'label: Left-to-right shunt\ndefinition : Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the left side of the heart to the right.\nsynonyms :\n'}


{'id': 'HP_0012383', 'url': 'http://purl.obolibrary.org/obo/HP_0012383', 'lbl': 'Bidirectional shunt', 'desc': 'label: Bidirectional shunt\ndefinition : Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from both right side of the heart to the left and vice versa.\nsynonyms :\n'}


{'id': 'HP_0012384', 'url': 'http://purl.obolibrary.org/obo/HP_0012384', 'lbl': 'Rhinitis', 'desc': 'label: Rhinitis\ndefinition : Inflammation of the nasal mucosa with nasal congestion.\nsynonyms :Nasal inflammation\n'}


{'id': 'HP_0012385', 'url': 'http://purl.obolibrary.org/obo/HP_0012385', 'lbl': 'Camptodactyly', 'desc': 'label: Camptodactyly\ndefinition : The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers or toes cannot be extended to 180 degrees by either active or passive extension.\nsynonyms :Permanent flexion of the finger or toe\n'}


{'id': 'HP_0012386', 'url': 'http://purl.obolibrary.org/obo/HP_0012386', 'lbl': 'Absent hallux', 'desc': 'label: Absent hallux\ndefinition : Aplasia of the hallux, that is, a development defect such that the big toe does not develop.\nsynonyms :Absent big toe; Agenesis of the halluces; Aplasia of the hallux; Missing big toe\n'}


{'id': 'HP_0012387', 'url': 'http://purl.obolibrary.org/obo/HP_0012387', 'lbl': 'Bronchitis', 'desc': 'label: Bronchitis\ndefinition : Inflammation of the large airways in the lung including any part of the bronchi from the primary bronchi to the tertiary bronchi.\nsynonyms :\n'}


{'id': 'HP_0012388', 'url': 'http://purl.obolibrary.org/obo/HP_0012388', 'lbl': 'Acute bronchitis', 'desc': 'label: Acute bronchitis\ndefinition : Inflammation of the large airways of the lung with rapid onset and short course usually associated with cough, mucus production, shortness of breath, wheezing, and chest tightness.\nsynonyms :\n'}


{'id': 'HP_0012389', 'url': 'http://purl.obolibrary.org/obo/HP_0012389', 'lbl': 'Appendicular hypotonia', 'desc': 'label: Appendicular hypotonia\ndefinition : Muscular hypotonia of one or more limbs.\nsynonyms :\n'}


{'id': 'HP_0012390', 'url': 'http://purl.obolibrary.org/obo/HP_0012390', 'lbl': 'Anal fissure', 'desc': 'label: Anal fissure\ndefinition : A small tear in the thin, moist tissue (mucosa) that lines the anus. It appears as a crack or slit in the mucous membrane of the anus.\nsynonyms :Anal erosion\n'}


{'id': 'HP_0012391', 'url': 'http://purl.obolibrary.org/obo/HP_0012391', 'lbl': 'Hyporeflexia of upper limbs', 'desc': 'label: Hyporeflexia of upper limbs\ndefinition : Reduced intensity of muscle tendon reflexes in the upper limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping.\nsynonyms :\n'}


{'id': 'HP_0012392', 'url': 'http://purl.obolibrary.org/obo/HP_0012392', 'lbl': 'Jaw hyporeflexia', 'desc': 'label: Jaw hyporeflexia\ndefinition : Reduced intensity of muscle tendon reflexes in jaw.\nsynonyms :Mandibular hyporeflexia\n'}


{'id': 'HP_0012393', 'url': 'http://purl.obolibrary.org/obo/HP_0012393', 'lbl': 'Allergy', 'desc': 'label: Allergy\ndefinition : An allergy is an immune response or reaction to substances that are usually not harmful.\nsynonyms :Allergy\n'}


{'id': 'HP_0012394', 'url': 'http://purl.obolibrary.org/obo/HP_0012394', 'lbl': 'Iodine contrast allergy', 'desc': 'label: Iodine contrast allergy\ndefinition : Allergy to iodine contrast media used in radiological studies.\nsynonyms :\n'}


{'id': 'HP_0012395', 'url': 'http://purl.obolibrary.org/obo/HP_0012395', 'lbl': 'Seasonal allergy', 'desc': 'label: Seasonal allergy\ndefinition : An allergy experienced at a particular time of year when trees or grasses pollinate and elicit an allergic reaction.\nsynonyms :Seasonal allergy\n'}


{'id': 'HP_0012396', 'url': 'http://purl.obolibrary.org/obo/HP_0012396', 'lbl': 'Biliary dyskinesia', 'desc': 'label: Biliary dyskinesia\ndefinition : A motility disorder characterized by biliary colic in the absence of gallstones with a reduced gallbladder ejection fraction.\nsynonyms :\n'}


{'id': 'HP_0012397', 'url': 'http://purl.obolibrary.org/obo/HP_0012397', 'lbl': 'Aortic atherosclerotic lesion', 'desc': 'label: Aortic atherosclerotic lesion\ndefinition : The presence of atheromas or atherosclerotic plaques in the aorta.\nsynonyms :Aortic atherosclerosis; Plaque build-up in aorta artery; Atherosclerosis of the aorta; Atherosclerotic changes of aorta\n'}


{'id': 'HP_0012398', 'url': 'http://purl.obolibrary.org/obo/HP_0012398', 'lbl': 'Peripheral edema', 'desc': 'label: Peripheral edema\ndefinition : An abnormal accumulation of interstitial fluid in the soft tissues of the limbs.\nsynonyms :Peripheral oedema\n'}


{'id': 'HP_0012399', 'url': 'http://purl.obolibrary.org/obo/HP_0012399', 'lbl': 'Pressure ulcer', 'desc': 'label: Pressure ulcer\ndefinition : A type of ulcer that is caused when an area of skin is subject to pressure over a prolonged period of time, ranging in range in severity from patches of discolored skin to open wounds that expose the underlying bone or muscle. The most common sites are the sacrum, coccyx, heels and the hips.\nsynonyms :Bedsore; Decubitus Ulcer; Pressure Sore; Pressure ulcer\n'}


{'id': 'HP_0012400', 'url': 'http://purl.obolibrary.org/obo/HP_0012400', 'lbl': 'Abnormal circulating aldolase concentration', 'desc': 'label: Abnormal circulating aldolase concentration\ndefinition : An abnormal concentration of aldolase in the serum. Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.\nsynonyms :Abnormal aldolase level\n'}


{'id': 'HP_0012401', 'url': 'http://purl.obolibrary.org/obo/HP_0012401', 'lbl': 'Abnormal urine alpha-ketoglutarate concentration', 'desc': 'label: Abnormal urine alpha-ketoglutarate concentration\ndefinition : A deviation from normal of the concentration of 2-oxoglutaric acid in the urine.\nsynonyms :Abnormal urinary 2-oxoglutarate level; Abnormality of urine alpha ketoglutarate concentration\n'}


{'id': 'HP_0012402', 'url': 'http://purl.obolibrary.org/obo/HP_0012402', 'lbl': 'Increased urine alpha-ketoglutarate concentration', 'desc': 'label: Increased urine alpha-ketoglutarate concentration\ndefinition : A greater than normal concentration of 2-oxoglutaric acid in the urine.\nsynonyms :Elevated urinary 2-oxoglutarate; Increased urine alpha-ketoglutarate concentration\n'}


{'id': 'HP_0012403', 'url': 'http://purl.obolibrary.org/obo/HP_0012403', 'lbl': 'Decreased urine alpha-ketoglutarate concentration', 'desc': 'label: Decreased urine alpha-ketoglutarate concentration\ndefinition : A lower than normal concentration of 2-oxoglutaric acid in the urine.\nsynonyms :Decreased urinary 2-oxoglutarate\n'}


{'id': 'HP_0012404', 'url': 'http://purl.obolibrary.org/obo/HP_0012404', 'lbl': 'Abnormal urine citrate concentration', 'desc': 'label: Abnormal urine citrate concentration\ndefinition : A deviation from normal of the concentration of citrate(3-) in the urine.\nsynonyms :Abnormal urine citrate concentration; Abnormal urine citric acid concentration\n'}


{'id': 'HP_0012405', 'url': 'http://purl.obolibrary.org/obo/HP_0012405', 'lbl': 'Hypocitraturia', 'desc': 'label: Hypocitraturia\ndefinition : A lower than normal concentration of citrate(3-) in the urine.\nsynonyms :Decreased urine citrate concentration\n'}


{'id': 'HP_0012406', 'url': 'http://purl.obolibrary.org/obo/HP_0012406', 'lbl': 'Hypercitraturia', 'desc': 'label: Hypercitraturia\ndefinition : A greater than normal concentration of citrate(3-) in the urine.\nsynonyms :Increased urine citrate concentration\n'}


{'id': 'HP_0012407', 'url': 'http://purl.obolibrary.org/obo/HP_0012407', 'lbl': 'Scissor gait', 'desc': 'label: Scissor gait\ndefinition : A type of spastic paraparetic gait in which the muscle tone in the adductors is marked. It is characterized by hypertonia and flexion in the legs, hips and pelvis accompanied by extreme adduction leading to the knees and thighs hitting, or sometimes even crossing, in a scissors-like movement. The opposing muscles (abductors) become comparatively weak from lack of use.\nsynonyms :Scissor gait; Scissor walk; Scissors gait\n'}


{'id': 'HP_0012408', 'url': 'http://purl.obolibrary.org/obo/HP_0012408', 'lbl': 'Medullary nephrocalcinosis', 'desc': 'label: Medullary nephrocalcinosis\ndefinition : The deposition of calcium salts in the parenchyma of the renal medulla (innermost part of the kidney).\nsynonyms :\n'}


{'id': 'HP_0012409', 'url': 'http://purl.obolibrary.org/obo/HP_0012409', 'lbl': 'Cortical nephrocalcinosis', 'desc': 'label: Cortical nephrocalcinosis\ndefinition : The deposition of calcium salts in the parenchyma of the renal cortex (the outer portion of the kidney between the renal capsule and the renal medulla).\nsynonyms :\n'}


{'id': 'HP_0012410', 'url': 'http://purl.obolibrary.org/obo/HP_0012410', 'lbl': 'Pure red cell aplasia', 'desc': 'label: Pure red cell aplasia\ndefinition : A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction.\nsynonyms :Red cell aplasia\n'}


{'id': 'HP_0012411', 'url': 'http://purl.obolibrary.org/obo/HP_0012411', 'lbl': 'Premature pubarche', 'desc': 'label: Premature pubarche\ndefinition : The onset of growth of pubic hair at an earlier age than normal.\nsynonyms :Premature pubic hair growth\n'}


{'id': 'HP_0012412', 'url': 'http://purl.obolibrary.org/obo/HP_0012412', 'lbl': 'Premature adrenarche', 'desc': 'label: Premature adrenarche\ndefinition : Onset of adrenarche at an earlier age than usual.\nsynonyms :\n'}


{'id': 'HP_0012413', 'url': 'http://purl.obolibrary.org/obo/HP_0012413', 'lbl': 'Notched primary central incisor', 'desc': 'label: Notched primary central incisor\ndefinition : The presence of a V-shaped indentation (notch) in the primary central incisor.\nsynonyms :Notched front baby tooth; Notched front deciduous tooth; Notched front primary tooth; Syphilitic primary incisor\n'}


{'id': 'HP_0012414', 'url': 'http://purl.obolibrary.org/obo/HP_0012414', 'lbl': 'Duodenal atrophy', 'desc': 'label: Duodenal atrophy\ndefinition : Wasting or decrease in size of all or part of the duodenum.\nsynonyms :\n'}


{'id': 'HP_0012415', 'url': 'http://purl.obolibrary.org/obo/HP_0012415', 'lbl': 'Abnormal blood gas level', 'desc': 'label: Abnormal blood gas level\ndefinition : An abnormality of the partial pressure of oxygen or carbon dioxide in the arterial blood.\nsynonyms :Abnormal blood gas level\n'}


{'id': 'HP_0012416', 'url': 'http://purl.obolibrary.org/obo/HP_0012416', 'lbl': 'Hypercapnia', 'desc': 'label: Hypercapnia\ndefinition : Abnormally elevated blood carbon dioxide (CO2) level.\nsynonyms :High blood carbon dioxide level; Hypercarbia\n'}


{'id': 'HP_0012417', 'url': 'http://purl.obolibrary.org/obo/HP_0012417', 'lbl': 'Hypocapnia', 'desc': 'label: Hypocapnia\ndefinition : Abnormally reduced blood carbon dioxide (CO2) level.\nsynonyms :Hypocarbia; Reduced carbon dioxide in the blood\n'}


{'id': 'HP_0012418', 'url': 'http://purl.obolibrary.org/obo/HP_0012418', 'lbl': 'Hypoxemia', 'desc': 'label: Hypoxemia\ndefinition : An abnormally low level of blood oxygen.\nsynonyms :Low blood oxygen level; Hypoxia\n'}


{'id': 'HP_0012419', 'url': 'http://purl.obolibrary.org/obo/HP_0012419', 'lbl': 'Hyperoxemia', 'desc': 'label: Hyperoxemia\ndefinition : An abnormally high level of blood oxygen.\nsynonyms :\n'}


{'id': 'HP_0012420', 'url': 'http://purl.obolibrary.org/obo/HP_0012420', 'lbl': 'Meconium stained amniotic fluid', 'desc': 'label: Meconium stained amniotic fluid\ndefinition : Amniotic fluid containing the earliest stools of a mammalian infant.\nsynonyms :Meconium staining of amniotic fluid; Meconium-stained amniotic fluid\n'}


{'id': 'HP_0012421', 'url': 'http://purl.obolibrary.org/obo/HP_0012421', 'lbl': 'Congenital absence of foreskin', 'desc': 'label: Congenital absence of foreskin\ndefinition : Congenital lack of the skin of prepuce of penis, that is, of the double-layered fold of skin and mucous membrane that covers the glans penis.\nsynonyms :Absent foreskin; Aposthia\n'}


{'id': 'HP_0012422', 'url': 'http://purl.obolibrary.org/obo/HP_0012422', 'lbl': 'Villous hypertrophy of choroid plexus', 'desc': 'label: Villous hypertrophy of choroid plexus\ndefinition : Overgrowth of the choroid plexus.\nsynonyms :Choroid plexus hypertrophy; Diffuse villous hypertrophy of choroid plexus\n'}


{'id': 'HP_0012423', 'url': 'http://purl.obolibrary.org/obo/HP_0012423', 'lbl': 'Colonic inertia', 'desc': 'label: Colonic inertia\ndefinition : The inability of the colon to modify stool to an acceptable consistency and move the stool from the cecum to the rectosigmoid area at least once every three days.\nsynonyms :\n'}


{'id': 'HP_0012424', 'url': 'http://purl.obolibrary.org/obo/HP_0012424', 'lbl': 'Chorioretinitis', 'desc': 'label: Chorioretinitis\ndefinition : An inflammation of the choroid and retina.\nsynonyms :\n'}


{'id': 'HP_0012425', 'url': 'http://purl.obolibrary.org/obo/HP_0012425', 'lbl': 'Stercoral ulcer', 'desc': 'label: Stercoral ulcer\ndefinition : An ulcer of the colon due to pressure and irritation from retained fecal masses.\nsynonyms :Colon ulcer; Recto-sigmoid colon stercoral ulcer\n'}


{'id': 'HP_0012426', 'url': 'http://purl.obolibrary.org/obo/HP_0012426', 'lbl': 'Optic disc drusen', 'desc': 'label: Optic disc drusen\ndefinition : Optic disc drusen are acellular, calcified deposits within the optic nerve head. Optic disc drusen are congenital and developmental anomalies of the optic nerve head, representing hyaline-containing bodies that, over time, appear as elevated, lumpy irregularities on the anterior portion of the optic nerve.\nsynonyms :Optic nerve head drusen\n'}


{'id': 'HP_0012427', 'url': 'http://purl.obolibrary.org/obo/HP_0012427', 'lbl': 'Increased femoral anteversion', 'desc': 'label: Increased femoral anteversion\ndefinition : An increased degree of femoral version, which is defined as the angular difference between axis of femoral neck and transcondylar axis of the knee. Thus, femoral anteversion is an inward twisting of the femur that causes the knees and feet to turn inward.\nsynonyms :Excessive femoral anteversion; Increased femoral neck anteversion; Internally rotated hips\n'}


{'id': 'HP_0012428', 'url': 'http://purl.obolibrary.org/obo/HP_0012428', 'lbl': 'Prominent calcaneus', 'desc': 'label: Prominent calcaneus\ndefinition : Protruding heel bone, or calcaneus.\nsynonyms :Prominent heel bone\n'}


{'id': 'HP_0012429', 'url': 'http://purl.obolibrary.org/obo/HP_0012429', 'lbl': 'Aplasia/Hypoplasia of the cerebral white matter', 'desc': 'label: Aplasia/Hypoplasia of the cerebral white matter\ndefinition : Absence or underdevelopment of the cerebral white matter.\nsynonyms :Absent/small cerebral white matter; Absent/underdeveloped cerebral white matter\n'}


{'id': 'HP_0012430', 'url': 'http://purl.obolibrary.org/obo/HP_0012430', 'lbl': 'Cerebral white matter hypoplasia', 'desc': 'label: Cerebral white matter hypoplasia\ndefinition : Underdevelopment of the cerebral white matter.\nsynonyms :Paucity of cerebral white matter\n'}


{'id': 'HP_0012431', 'url': 'http://purl.obolibrary.org/obo/HP_0012431', 'lbl': 'Episodic fatigue', 'desc': 'label: Episodic fatigue\ndefinition : Intermittent and recurrent bouts of a subjective feeling of tiredness characterized by a lack of energy and motivation.\nsynonyms :\n'}


{'id': 'HP_0012432', 'url': 'http://purl.obolibrary.org/obo/HP_0012432', 'lbl': 'Chronic fatigue', 'desc': 'label: Chronic fatigue\ndefinition : Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.\nsynonyms :Chronic extreme exhaustion; Chronic fatigue\n'}


{'id': 'HP_0012433', 'url': 'http://purl.obolibrary.org/obo/HP_0012433', 'lbl': 'Abnormal social behavior', 'desc': 'label: Abnormal social behavior\ndefinition : An abnormality of actions or reactions of a person taking place during interactions with others.\nsynonyms :Abnormal social behavior; Abnormal social behaviour; Abnormal social interactions\n'}


{'id': 'HP_0012434', 'url': 'http://purl.obolibrary.org/obo/HP_0012434', 'lbl': 'Delayed social development', 'desc': 'label: Delayed social development\ndefinition : A failure to meet one or more age-related milestones of social behavior.\nsynonyms :Delayed social development\n'}


{'id': 'HP_0012435', 'url': 'http://purl.obolibrary.org/obo/HP_0012435', 'lbl': 'Ventral shortening of foreskin', 'desc': 'label: Ventral shortening of foreskin\ndefinition : Reduction in length of the ventral (lower) skin of prepuce of penis.\nsynonyms :\n'}


{'id': 'HP_0012436', 'url': 'http://purl.obolibrary.org/obo/HP_0012436', 'lbl': 'Nonocclusive coronary artery atherosclerosis', 'desc': 'label: Nonocclusive coronary artery atherosclerosis\ndefinition : Coronary disease that has not progressed to the point of causing significant occlusion (blockage) of the coronary arteries.\nsynonyms :Non-occlusive coronary artery disease; Non-occlusive coronary artery stenosis; Nonocclusive coronary artery disease; Nonocclusive coronary artery stenosis\n'}


{'id': 'HP_0012437', 'url': 'http://purl.obolibrary.org/obo/HP_0012437', 'lbl': 'Abnormal gallbladder morphology', 'desc': 'label: Abnormal gallbladder morphology\ndefinition : A structural anomaly of the gallbladder.\nsynonyms :Abnormal gallbladder structure; Abnormal shape of gallbladder\n'}


{'id': 'HP_0012438', 'url': 'http://purl.obolibrary.org/obo/HP_0012438', 'lbl': 'Abnormal gallbladder physiology', 'desc': 'label: Abnormal gallbladder physiology\ndefinition : A functional anomaly of the gallbladder.\nsynonyms :\n'}


{'id': 'HP_0012439', 'url': 'http://purl.obolibrary.org/obo/HP_0012439', 'lbl': 'Abnormal biliary tract physiology', 'desc': 'label: Abnormal biliary tract physiology\ndefinition : A functional abnormality of the biliary tree.\nsynonyms :\n'}


{'id': 'HP_0012440', 'url': 'http://purl.obolibrary.org/obo/HP_0012440', 'lbl': 'Abnormal biliary tract morphology', 'desc': 'label: Abnormal biliary tract morphology\ndefinition : A structural abnormality of the biliary tree.\nsynonyms :Anomaly of the biliary tract\n'}


{'id': 'HP_0012441', 'url': 'http://purl.obolibrary.org/obo/HP_0012441', 'lbl': 'Sphincter of Oddi dyskinesia', 'desc': 'label: Sphincter of Oddi dyskinesia\ndefinition : Reduced motility through the sphincter of Oddi, resulting in impedance of bile and pancreatic juice flow from the common bile duct into the duodenum.\nsynonyms :Sphincter of Oddi dysfunction\n'}


{'id': 'HP_0012442', 'url': 'http://purl.obolibrary.org/obo/HP_0012442', 'lbl': 'Gallbladder dyskinesia', 'desc': 'label: Gallbladder dyskinesia\ndefinition : Reduced motility of the gallbladder with reduced emptying fraction.\nsynonyms :\n'}


{'id': 'HP_0012443', 'url': 'http://purl.obolibrary.org/obo/HP_0012443', 'lbl': 'Abnormality of brain morphology', 'desc': 'label: Abnormality of brain morphology\ndefinition : A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain.\nsynonyms :Abnormal shape of brain; Abnormality of the brain\n'}


{'id': 'HP_0012444', 'url': 'http://purl.obolibrary.org/obo/HP_0012444', 'lbl': 'Brain atrophy', 'desc': 'label: Brain atrophy\ndefinition : Partial or complete wasting (loss) of brain tissue that was once present.\nsynonyms :Brain degeneration; Brain wasting\n'}


{'id': 'HP_0012446', 'url': 'http://purl.obolibrary.org/obo/HP_0012446', 'lbl': 'Decreased CSF 5-methyltetrahydrofolate concentration', 'desc': 'label: Decreased CSF 5-methyltetrahydrofolate concentration\ndefinition : A reduced concentration of 5-methyltetrahydrofolate(2-) in the cerebrospinal fluid (CSF). 5-methyltetrahydrofolate is the active folate metabolite.\nsynonyms :Low CSF 5-methyltetrahydrofolate; Reduced CSF 5-methyltetrahydrofolate concentration; Cerebral folate deficiency\n'}


{'id': 'HP_0012447', 'url': 'http://purl.obolibrary.org/obo/HP_0012447', 'lbl': 'Abnormal myelination', 'desc': 'label: Abnormal myelination\ndefinition : Any anomaly in the process by which myelin sheaths are formed and maintained around neurons.\nsynonyms :\n'}


{'id': 'HP_0012448', 'url': 'http://purl.obolibrary.org/obo/HP_0012448', 'lbl': 'Delayed myelination', 'desc': 'label: Delayed myelination\ndefinition : Delayed myelination.\nsynonyms :\n'}


{'id': 'HP_0012449', 'url': 'http://purl.obolibrary.org/obo/HP_0012449', 'lbl': 'Sacroiliac joint synovitis', 'desc': 'label: Sacroiliac joint synovitis\ndefinition : Inflammation of the synovial membrane of the sacroiliac joint.\nsynonyms :\n'}


{'id': 'HP_0012450', 'url': 'http://purl.obolibrary.org/obo/HP_0012450', 'lbl': 'Chronic constipation', 'desc': 'label: Chronic constipation\ndefinition : Constipation for longer than three months with fewer than 3 bowel movements per week, straining, lumpy or hard stools, and a sensation of anorectal obstruction or incomplete defecation.\nsynonyms :Chronic constipation; Infrequent bowel movements\n'}


{'id': 'HP_0012451', 'url': 'http://purl.obolibrary.org/obo/HP_0012451', 'lbl': 'Acute constipation', 'desc': 'label: Acute constipation\ndefinition : Constipation of sudden onset and lasting for less than three months.\nsynonyms :\n'}


{'id': 'HP_0012452', 'url': 'http://purl.obolibrary.org/obo/HP_0012452', 'lbl': 'Restless legs', 'desc': 'label: Restless legs\ndefinition : A feeling of uneasiness and restlessness in the legs after going to bed (sometimes causing insomnia).\nsynonyms :Restless legs syndrome; Willis-Ekbom disease; Wittmaack-Ekbom syndrome\n'}


{'id': 'HP_0012453', 'url': 'http://purl.obolibrary.org/obo/HP_0012453', 'lbl': 'Bilateral wrist flexion contracture', 'desc': 'label: Bilateral wrist flexion contracture\ndefinition : A chronic loss of wrist joint motion on the right and left sides.\nsynonyms :Bilateral wrist contracture\n'}


{'id': 'HP_0012454', 'url': 'http://purl.obolibrary.org/obo/HP_0012454', 'lbl': 'Unilateral wrist flexion contracture', 'desc': 'label: Unilateral wrist flexion contracture\ndefinition : A chronic loss of wrist joint motion on one side only.\nsynonyms :Unilateral wrist contracture\n'}


{'id': 'HP_0012455', 'url': 'http://purl.obolibrary.org/obo/HP_0012455', 'lbl': 'obsolete Large artery calcification', 'desc': 'label: obsolete Large artery calcification\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0012456', 'url': 'http://purl.obolibrary.org/obo/HP_0012456', 'lbl': 'Medial arterial calcification', 'desc': 'label: Medial arterial calcification\ndefinition : Calcification, that is, pathological deposition of calcium salts in the tunica media of arteries.\nsynonyms :\n'}


{'id': 'HP_0012457', 'url': 'http://purl.obolibrary.org/obo/HP_0012457', 'lbl': 'Medial calcification of medium-sized arteries', 'desc': 'label: Medial calcification of medium-sized arteries\ndefinition : Calcification, that is, pathological deposition of calcium salts in the tunica media of medium-sized (muscular or distributive) arteries.\nsynonyms :\n'}


{'id': 'HP_0012458', 'url': 'http://purl.obolibrary.org/obo/HP_0012458', 'lbl': 'Medial calcification of small arteries', 'desc': 'label: Medial calcification of small arteries\ndefinition : Calcification, that is, pathological deposition of calcium salts in the tunica media of small arteries.\nsynonyms :\n'}


{'id': 'HP_0012459', 'url': 'http://purl.obolibrary.org/obo/HP_0012459', 'lbl': 'Hypnic headache', 'desc': 'label: Hypnic headache\ndefinition : A headache disorder that occurs exclusively at night, waking the affected individual from sleep.\nsynonyms :Alarm clock headache\n'}


{'id': 'HP_0012460', 'url': 'http://purl.obolibrary.org/obo/HP_0012460', 'lbl': 'Dysmorphic inferior cerebellar vermis', 'desc': 'label: Dysmorphic inferior cerebellar vermis\ndefinition : A structural anomaly of the inferior portion of the vermis of cerebellum.\nsynonyms :\n'}


{'id': 'HP_0012461', 'url': 'http://purl.obolibrary.org/obo/HP_0012461', 'lbl': 'Bacteriuria', 'desc': 'label: Bacteriuria\ndefinition : The presence of bacteria in the urine.\nsynonyms :Bacteria in urine; High urine bacteria\n'}


{'id': 'HP_0012462', 'url': 'http://purl.obolibrary.org/obo/HP_0012462', 'lbl': 'Chin myoclonus', 'desc': 'label: Chin myoclonus\ndefinition : Involuntary and irregular twitches of the chin.\nsynonyms :Geniospasm; Chin spasms\n'}


{'id': 'HP_0012463', 'url': 'http://purl.obolibrary.org/obo/HP_0012463', 'lbl': 'Elevated transferrin saturation', 'desc': 'label: Elevated transferrin saturation\ndefinition : An above normal level of saturation of serum transferrin with iron.\nsynonyms :\n'}


{'id': 'HP_0012464', 'url': 'http://purl.obolibrary.org/obo/HP_0012464', 'lbl': 'Decreased transferrin saturation', 'desc': 'label: Decreased transferrin saturation\ndefinition : A below normal level of saturation of serum transferrin with iron.\nsynonyms :\n'}


{'id': 'HP_0012465', 'url': 'http://purl.obolibrary.org/obo/HP_0012465', 'lbl': 'Elevated hepatic iron concentration', 'desc': 'label: Elevated hepatic iron concentration\ndefinition : An increased level of iron in liver tissues.\nsynonyms :Increased iron concentration in liver; Increased liver iron level\n'}


{'id': 'HP_0012466', 'url': 'http://purl.obolibrary.org/obo/HP_0012466', 'lbl': 'Chronic respiratory acidosis', 'desc': 'label: Chronic respiratory acidosis\ndefinition : Longstanding impairment in ventilation such that the partial pressure of carbon dioxide (PaCO2) is elevated above the upper limit of the reference range (more than 45 mm Hg), with a normal or near-normal pH secondary to renal compensation and an elevated serum bicarbonate levels (more than30 mEq/L).\nsynonyms :\n'}


{'id': 'HP_0012467', 'url': 'http://purl.obolibrary.org/obo/HP_0012467', 'lbl': 'Acute respiratory acidosis', 'desc': 'label: Acute respiratory acidosis\ndefinition : Sudden onset of impairment in ventilation such that the removal of carbon dioxide by the respiratory system is less than the production of carbon dioxide in the tissues, leading to an elevation of the partial pressure of carbon dioxide (PaCO2) above the normal limits (more than 45 mm Hg) with an accompanying acidemia (pH less than 7.35).\nsynonyms :\n'}


{'id': 'HP_0012468', 'url': 'http://purl.obolibrary.org/obo/HP_0012468', 'lbl': 'Chronic acidosis', 'desc': 'label: Chronic acidosis\ndefinition : Longstanding abnormal acid accumulation or depletion of base.\nsynonyms :\n'}


{'id': 'HP_0012469', 'url': 'http://purl.obolibrary.org/obo/HP_0012469', 'lbl': 'Infantile spasms', 'desc': 'label: Infantile spasms\ndefinition : Infantile spasms represent a subset of "epileptic spasms". Infantile Spasms are epileptic spasms starting in the first year of life (infancy).\nsynonyms :\n'}


{'id': 'HP_0012470', 'url': 'http://purl.obolibrary.org/obo/HP_0012470', 'lbl': 'Setting-sun eye phenomenon', 'desc': 'label: Setting-sun eye phenomenon\ndefinition : An ophthalmologic sign in young children resulting from upward-gaze paresis. In this condition, the eyes appear driven downward, the sclera may be seen between the upper eyelid and the iris, and part of the lower pupil may be covered by the lower eyelid.\nsynonyms :Setting-sun eye phenomenon; Sun setting eyes; Sunsetting eye; Eyes fixed downward\n'}


{'id': 'HP_0012471', 'url': 'http://purl.obolibrary.org/obo/HP_0012471', 'lbl': 'Thick vermilion border', 'desc': 'label: Thick vermilion border\ndefinition : Increased width of the skin of vermilion border region of upper lip.\nsynonyms :Full lips; Increased volume of lip; Increased volume of lip vermillion; Plump lips; Prominent lips; Thick lips\n'}


{'id': 'HP_0012472', 'url': 'http://purl.obolibrary.org/obo/HP_0012472', 'lbl': 'Eclabion', 'desc': 'label: Eclabion\ndefinition : A turning outward of the lip or lips, that is, eversion of the lips.\nsynonyms :Eclabium; Everted lips; Outward turned lips\n'}


{'id': 'HP_0012473', 'url': 'http://purl.obolibrary.org/obo/HP_0012473', 'lbl': 'Tongue atrophy', 'desc': 'label: Tongue atrophy\ndefinition : Wasting of the tongue.\nsynonyms :Atrophy of the tongue; Lingual atrophy; Lingual wasting; Wasting of the tongue\n'}


{'id': 'HP_0012474', 'url': 'http://purl.obolibrary.org/obo/HP_0012474', 'lbl': 'Carotid artery occlusion', 'desc': 'label: Carotid artery occlusion\ndefinition : Complete obstruction of a carotid artery.\nsynonyms :Obstructed carotid artery\n'}


{'id': 'HP_0012475', 'url': 'http://purl.obolibrary.org/obo/HP_0012475', 'lbl': 'Decreased circulating level of specific antibody', 'desc': 'label: Decreased circulating level of specific antibody\ndefinition : The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against a specific antigen or microorganism.\nsynonyms :Abnormal specific antibody response; Decreased specific antibody in blood; Specific antibody deficiency\n'}


{'id': 'HP_0012476', 'url': 'http://purl.obolibrary.org/obo/HP_0012476', 'lbl': 'Decreased specific pneumococcal antibody level', 'desc': 'label: Decreased specific pneumococcal antibody level\ndefinition : The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against pneumococci.\nsynonyms :Low pneumococcal antibody titer; Specific pneumococcal antibody deficiency\n'}


{'id': 'HP_0012477', 'url': 'http://purl.obolibrary.org/obo/HP_0012477', 'lbl': 'Vocal tremor', 'desc': 'label: Vocal tremor\ndefinition : A wavering, unsteady voice that reflects involuntary and approximately sinusoidal oscillation of motor unit firings of laryngeal muscles. Vocal tremor results in low frequency modulations of voice frequency or amplitude and intermittent voice instability.\nsynonyms :Shakey voice; Vocal tremor\n'}


{'id': 'HP_0012478', 'url': 'http://purl.obolibrary.org/obo/HP_0012478', 'lbl': 'Temporomandibular joint ankylosis', 'desc': 'label: Temporomandibular joint ankylosis\ndefinition : Bony fusion of the mandibular condyle to the base of the skull, resulting in limitation of jaw opening.\nsynonyms :Ankylosis of temporomandibular joint; Freezing of jaw joint; Freezing of the temporomandibular joint; Rigidity of the temporomandibular joint; Temporomandibular joint fusion; Adhesion of the temporomandibular joint\n'}


{'id': 'HP_0012479', 'url': 'http://purl.obolibrary.org/obo/HP_0012479', 'lbl': 'Temporomandibular joint crepitus', 'desc': 'label: Temporomandibular joint crepitus\ndefinition : Noises from the temporomandibular joint during mandibular movement (e.g., chewing). Temporomandibular joint crepitus is often described as a clicking, popping, grating sound.\nsynonyms :Jaw joint noise; Jaw joint sounds; Temporomandibular joint noise; Temporomandibular joint sounds; Jaw joint crepitus; Jaw joint clicking sound; Jaw joint grating sound; Jaw joint popping sound; Temporomandibular joint clicking sound; Temporomandibular joint grating sound; Temporomandibular joint popping sound\n'}


{'id': 'HP_0012480', 'url': 'http://purl.obolibrary.org/obo/HP_0012480', 'lbl': 'Abnormal cerebral vein morphology', 'desc': 'label: Abnormal cerebral vein morphology\ndefinition : An anomaly of cerebral veins.\nsynonyms :Abnormality of cerebral veins\n'}


{'id': 'HP_0012481', 'url': 'http://purl.obolibrary.org/obo/HP_0012481', 'lbl': 'Cerebral venous angioma', 'desc': 'label: Cerebral venous angioma\ndefinition : A congenital malformation of veins which drain normal brain characterized by a caput medusae or an umbrellalike convergence of multiple venules on a single, or occasionally multiple, enlarged parenchymal or medullary vein, like the trunk of a tree or the shank of an umbrella. This dilated terminal vein penetrates the cortex to drain either (a) superficially to cortical veins or sinuses, (b) deeply to subependymal veins of the lateral ventricle and then into the galenic system, (c) to the fourth ventricle and then to the pontomesencephalic vein, or (d) to the precentral cerebellar vein and into the galenic system.\nsynonyms :Developmental Venous Anomaly\n'}


{'id': 'HP_0012482', 'url': 'http://purl.obolibrary.org/obo/HP_0012482', 'lbl': 'Frontal venous angioma', 'desc': 'label: Frontal venous angioma\ndefinition : A venous angioma of the frontal lobe of the brain.\nsynonyms :\n'}


{'id': 'HP_0012483', 'url': 'http://purl.obolibrary.org/obo/HP_0012483', 'lbl': 'Abnormal alpha granules', 'desc': 'label: Abnormal alpha granules\ndefinition : Defective structure, size or content of alpha granules, platelet organelles that contain several growth factors destined for release during platelet activation at sites of vessel wall injury.\nsynonyms :\n'}


{'id': 'HP_0012484', 'url': 'http://purl.obolibrary.org/obo/HP_0012484', 'lbl': 'Abnormal dense granules', 'desc': 'label: Abnormal dense granules\ndefinition : Defective structure, size or content of dense granules, platelet organelles that contain granules proaggregatory factors such as adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium, histamine and serotonin.\nsynonyms :\n'}


{'id': 'HP_0012485', 'url': 'http://purl.obolibrary.org/obo/HP_0012485', 'lbl': 'Abnormal surface-connected open canalicular system', 'desc': 'label: Abnormal surface-connected open canalicular system\ndefinition : An anomaly of the invaginations of the surface membrane that form the open canalicular system (OCS). The OCS serve as the pathway for transport of substances into the cells and as conduits for the discharge of alpha granule products secreted during the platelet release reaction.\nsynonyms :\n'}


{'id': 'HP_0012486', 'url': 'http://purl.obolibrary.org/obo/HP_0012486', 'lbl': 'Myelitis', 'desc': 'label: Myelitis\ndefinition : Inflammation of the spinal cord.\nsynonyms :Inflammation of spinal cord\n'}


{'id': 'HP_0012487', 'url': 'http://purl.obolibrary.org/obo/HP_0012487', 'lbl': 'Cerebellopontine angle arachnoid cyst', 'desc': 'label: Cerebellopontine angle arachnoid cyst\ndefinition : An arachnoid cyst located at the margin of the cerebellum and pons.\nsynonyms :\n'}


{'id': 'HP_0012488', 'url': 'http://purl.obolibrary.org/obo/HP_0012488', 'lbl': 'Intraventricular arachnoid cyst', 'desc': 'label: Intraventricular arachnoid cyst\ndefinition : An arachnoid cyst located within the ventricular system.\nsynonyms :\n'}


{'id': 'HP_0012489', 'url': 'http://purl.obolibrary.org/obo/HP_0012489', 'lbl': 'Suprasellar arachnoid cyst', 'desc': 'label: Suprasellar arachnoid cyst\ndefinition : An arachnoid cyst that progressively enlarges from an abnormality in the membrane of Liliequist or in the interpeduncular cistern, and typically, expands from the prepontine space, displacing the floor of the third ventricle upwards, the pituitary stalk and optic chiasm upwards and forwards, and the mammillary bodies upwards and backwards.\nsynonyms :\n'}


{'id': 'HP_0012490', 'url': 'http://purl.obolibrary.org/obo/HP_0012490', 'lbl': 'Panniculitis', 'desc': 'label: Panniculitis\ndefinition : Inflammation of adipose tissue.\nsynonyms :Inflammation of adipose tissue; Inflammation of fat tissue\n'}


{'id': 'HP_0012491', 'url': 'http://purl.obolibrary.org/obo/HP_0012491', 'lbl': 'Abnormal dense tubular system', 'desc': 'label: Abnormal dense tubular system\ndefinition : An anomaly of the intracellular membrane complexes known as the dense tubular system.\nsynonyms :\n'}


{'id': 'HP_0012492', 'url': 'http://purl.obolibrary.org/obo/HP_0012492', 'lbl': 'Cerebral artery stenosis', 'desc': 'label: Cerebral artery stenosis\ndefinition : Narrowing or constriction of the inner surface (lumen) of a cerebral artery.\nsynonyms :Narrowing of a cerebral artery\n'}


{'id': 'HP_0012493', 'url': 'http://purl.obolibrary.org/obo/HP_0012493', 'lbl': 'Middle cerebral artery stenosis', 'desc': 'label: Middle cerebral artery stenosis\ndefinition : Narrowing or constriction of the inner surface (lumen) of the middle cerebral artery.\nsynonyms :\n'}


{'id': 'HP_0012494', 'url': 'http://purl.obolibrary.org/obo/HP_0012494', 'lbl': 'Anterior cerebral artery stenosis', 'desc': 'label: Anterior cerebral artery stenosis\ndefinition : Narrowing or constriction of the inner surface (lumen) of the anterior cerebral artery.\nsynonyms :\n'}


{'id': 'HP_0012495', 'url': 'http://purl.obolibrary.org/obo/HP_0012495', 'lbl': 'Posterior cerebral artery stenosis', 'desc': 'label: Posterior cerebral artery stenosis\ndefinition : Narrowing or constriction of the inner surface (lumen) of the posterior cerebral artery.\nsynonyms :\n'}


{'id': 'HP_0012496', 'url': 'http://purl.obolibrary.org/obo/HP_0012496', 'lbl': 'Reduced maximal inspiratory pressure', 'desc': 'label: Reduced maximal inspiratory pressure\ndefinition : A decrease in the maximum amount of negative pressure a person can generate during an inhalation.\nsynonyms :\n'}


{'id': 'HP_0012497', 'url': 'http://purl.obolibrary.org/obo/HP_0012497', 'lbl': 'Reduced maximal expiratory pressure', 'desc': 'label: Reduced maximal expiratory pressure\ndefinition : A decrease in the maximum amount of pressure of expired air achieved by a person after a full inspiration.\nsynonyms :\n'}


{'id': 'HP_0012498', 'url': 'http://purl.obolibrary.org/obo/HP_0012498', 'lbl': 'Nuchal cord', 'desc': 'label: Nuchal cord\ndefinition : A complication of pregnancy and delivery in which the umbilical cord wraps around the fetal neck once or multiple times.\nsynonyms :\n'}


{'id': 'HP_0012499', 'url': 'http://purl.obolibrary.org/obo/HP_0012499', 'lbl': 'Descending aortic dissection', 'desc': 'label: Descending aortic dissection\ndefinition : A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space.\nsynonyms :Type B aortic dissection\n'}


{'id': 'HP_0012500', 'url': 'http://purl.obolibrary.org/obo/HP_0012500', 'lbl': 'Verrucous papule', 'desc': 'label: Verrucous papule\ndefinition : A wartlike (with multiple small elevated projections) papule.\nsynonyms :Papillomatous papule\n'}


{'id': 'HP_0012501', 'url': 'http://purl.obolibrary.org/obo/HP_0012501', 'lbl': 'Abnormal brainstem white matter morphology', 'desc': 'label: Abnormal brainstem white matter morphology\ndefinition : An anomaly of the white matter of brainstem.\nsynonyms :Abnormality of the brainstem white matter\n'}


{'id': 'HP_0012502', 'url': 'http://purl.obolibrary.org/obo/HP_0012502', 'lbl': 'Abnormality of the internal capsule', 'desc': 'label: Abnormality of the internal capsule\ndefinition : An anomaly of the internal capsule, which is an area of white matter in the brain that separates the caudate nucleus and the thalamus from the putamen and the globus pallidus.\nsynonyms :\n'}


{'id': 'HP_0012503', 'url': 'http://purl.obolibrary.org/obo/HP_0012503', 'lbl': 'Abnormality of the pituitary gland', 'desc': 'label: Abnormality of the pituitary gland\ndefinition : An anomaly of the pituitary gland.\nsynonyms :disorder of pituitary gland\n'}


{'id': 'HP_0012504', 'url': 'http://purl.obolibrary.org/obo/HP_0012504', 'lbl': 'Abnormal size of pituitary gland', 'desc': 'label: Abnormal size of pituitary gland\ndefinition : A deviation from the normal size of the pituitary gland.\nsynonyms :\n'}


{'id': 'HP_0012505', 'url': 'http://purl.obolibrary.org/obo/HP_0012505', 'lbl': 'Enlarged pituitary gland', 'desc': 'label: Enlarged pituitary gland\ndefinition : An abnormally increased size of the pituitary gland.\nsynonyms :\n'}


{'id': 'HP_0012506', 'url': 'http://purl.obolibrary.org/obo/HP_0012506', 'lbl': 'Small pituitary gland', 'desc': 'label: Small pituitary gland\ndefinition : An abnormally decreased size of the pituitary gland.\nsynonyms :\n'}


{'id': 'HP_0012507', 'url': 'http://purl.obolibrary.org/obo/HP_0012507', 'lbl': 'Weakness of orbicularis oculi muscle', 'desc': 'label: Weakness of orbicularis oculi muscle\ndefinition : Reduced strength of the orbicularis oculi, the circumorbital muscle in the face that closes the eyelid.\nsynonyms :Weakness of orbicularis oculi muscles\n'}


{'id': 'HP_0012508', 'url': 'http://purl.obolibrary.org/obo/HP_0012508', 'lbl': 'Metamorphopsia', 'desc': 'label: Metamorphopsia\ndefinition : A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank.\nsynonyms :\n'}


{'id': 'HP_0012509', 'url': 'http://purl.obolibrary.org/obo/HP_0012509', 'lbl': 'Reduced thyroxin-binding globulin', 'desc': "label: Reduced thyroxin-binding globulin\ndefinition : An abnormally decreased amount of thyroxin-binding globulin (TBG) in blood. TBG is responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream.\nsynonyms :\n"}


{'id': 'HP_0012510', 'url': 'http://purl.obolibrary.org/obo/HP_0012510', 'lbl': 'Extra-axial cerebrospinal fluid accumulation', 'desc': 'label: Extra-axial cerebrospinal fluid accumulation\ndefinition : An increased amount of cerebrospinal fluid (CSF) in the subarachnoid space.\nsynonyms :Extra-axial CSF accumulation\n'}


{'id': 'HP_0012511', 'url': 'http://purl.obolibrary.org/obo/HP_0012511', 'lbl': 'Temporal optic disc pallor', 'desc': 'label: Temporal optic disc pallor\ndefinition : A pale yellow discoloration of the temporal (lateral) portion of the optic disc.\nsynonyms :\n'}


{'id': 'HP_0012512', 'url': 'http://purl.obolibrary.org/obo/HP_0012512', 'lbl': 'Diffuse optic disc pallor', 'desc': 'label: Diffuse optic disc pallor\ndefinition : A pale yellow discoloration of the entire optic disc.\nsynonyms :\n'}


{'id': 'HP_0012513', 'url': 'http://purl.obolibrary.org/obo/HP_0012513', 'lbl': 'Upper limb pain', 'desc': 'label: Upper limb pain\ndefinition : An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the arm.\nsynonyms :Upper limb pain\n'}


{'id': 'HP_0012514', 'url': 'http://purl.obolibrary.org/obo/HP_0012514', 'lbl': 'Lower limb pain', 'desc': 'label: Lower limb pain\ndefinition : An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the leg.\nsynonyms :Leg pain; Lower limb pain\n'}


{'id': 'HP_0012515', 'url': 'http://purl.obolibrary.org/obo/HP_0012515', 'lbl': 'Hip flexor weakness', 'desc': 'label: Hip flexor weakness\ndefinition : Reduced ability to flex the femur, that is, to pull the knee upward.\nsynonyms :\n'}


{'id': 'HP_0012516', 'url': 'http://purl.obolibrary.org/obo/HP_0012516', 'lbl': 'Tetralogy of Fallot with pulmonary atresia', 'desc': 'label: Tetralogy of Fallot with pulmonary atresia\ndefinition : An extreme form of tetralogy of Fallot characterized by absence of flow from the right ventricle to the pulmonary arteries.\nsynonyms :\n'}


{'id': 'HP_0012517', 'url': 'http://purl.obolibrary.org/obo/HP_0012517', 'lbl': 'Reduced catalase level', 'desc': 'label: Reduced catalase level\ndefinition : An abnormally decreased amount of catalase level.\nsynonyms :\n'}


{'id': 'HP_0012518', 'url': 'http://purl.obolibrary.org/obo/HP_0012518', 'lbl': 'Abnormal circle of Willis morphology', 'desc': 'label: Abnormal circle of Willis morphology\ndefinition : An anomaly of the circle of Willis, also known as the cerebral arterial circle.\nsynonyms :Abnormality of the cerebral arterial circle\n'}


{'id': 'HP_0012519', 'url': 'http://purl.obolibrary.org/obo/HP_0012519', 'lbl': 'Hypoplastic posterior communicating artery', 'desc': 'label: Hypoplastic posterior communicating artery\ndefinition : A developmental anomnaly characterized by underdevelopment of the posterior communicating artery.\nsynonyms :Hypoplastic posterior communicating arteries\n'}


{'id': 'HP_0012520', 'url': 'http://purl.obolibrary.org/obo/HP_0012520', 'lbl': 'Dilation of Virchow-Robin spaces', 'desc': 'label: Dilation of Virchow-Robin spaces\ndefinition : Increased dimensions of the Virchow-Robin spaces (also known as perivascular spaces), which surround the walls of vessels as they course from the subarachnoid space through the brain parenchyma. Perivascular spaces are commonly microscopic, and not visible on conventional neuroimaging. This term refers to an increase of size of these spaces such that they are visible on neuroimaging (usually magnetic resonance imaging). The dilatations are regular cavities that always contain a patent artery.\nsynonyms :Dilated Virchow-Robin spaces; Perivascular spaces; Dilated cerebral perivascular spaces\n'}


{'id': 'HP_0012521', 'url': 'http://purl.obolibrary.org/obo/HP_0012521', 'lbl': 'Optic nerve aplasia', 'desc': 'label: Optic nerve aplasia\ndefinition : Congenital absence of the optic nerve.\nsynonyms :Absent optic nerve; Aplastic optic nerve\n'}


{'id': 'HP_0012522', 'url': 'http://purl.obolibrary.org/obo/HP_0012522', 'lbl': 'Spider hemangioma', 'desc': 'label: Spider hemangioma\ndefinition : A form of telangiectasis characterized by a central elevated red dot the size of a pinhead, representing an arteriole, with numerous small blood vessels that radiate out thereby resembling the legs of a spider. Characteristically, compression of the central arteriole causes the entire lesion to blanch, and the lesion quickly refills once the compression is released.\nsynonyms :\n'}


{'id': 'HP_0012523', 'url': 'http://purl.obolibrary.org/obo/HP_0012523', 'lbl': 'Oral aversion', 'desc': 'label: Oral aversion\ndefinition : Reluctance or refusal of a child to be breastfed or eat, manifested as gagging, vomiting, turning head away from food, or avoidance of sensation in or around the mouth (i.e. toothbrushing or face-washing).\nsynonyms :\n'}


{'id': 'HP_0012524', 'url': 'http://purl.obolibrary.org/obo/HP_0012524', 'lbl': 'Abnormal platelet shape', 'desc': 'label: Abnormal platelet shape\ndefinition : A deviation from the normal discoid platelet shape.\nsynonyms :\n'}


{'id': 'HP_0012525', 'url': 'http://purl.obolibrary.org/obo/HP_0012525', 'lbl': 'Abnormal alpha granule distribution', 'desc': 'label: Abnormal alpha granule distribution\ndefinition : An anomalous location and arrangement of platelet alpha granules.\nsynonyms :\n'}


{'id': 'HP_0012526', 'url': 'http://purl.obolibrary.org/obo/HP_0012526', 'lbl': 'Absence of alpha granules', 'desc': 'label: Absence of alpha granules\ndefinition : A lack of platelet alpha granules. This typically results in the grey appearance of platelets in giemsa stained blood smears.\nsynonyms :Gray platelets; Grey platelets\n'}


{'id': 'HP_0012527', 'url': 'http://purl.obolibrary.org/obo/HP_0012527', 'lbl': 'Abnormal alpha granule content', 'desc': 'label: Abnormal alpha granule content\ndefinition : A deviation from the normal contents of the platelet alpha granules, which normally contain hemostatic proteins such as fibrinogen, von Willebrand factor, and growth factors such as platelet-derived growth factor.\nsynonyms :\n'}


{'id': 'HP_0012528', 'url': 'http://purl.obolibrary.org/obo/HP_0012528', 'lbl': 'Abnormal number of alpha granules', 'desc': 'label: Abnormal number of alpha granules\ndefinition : A deviation from the normal count of alpha granules per thrombocyte.\nsynonyms :\n'}


{'id': 'HP_0012529', 'url': 'http://purl.obolibrary.org/obo/HP_0012529', 'lbl': 'Abnormal dense granule content', 'desc': 'label: Abnormal dense granule content\ndefinition : A deviation from the normal contents of the platelet alpha granules, which normally contain adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin, calcium, and pyrophosphate, which are secreted when platelets are activated.\nsynonyms :\n'}


{'id': 'HP_0012530', 'url': 'http://purl.obolibrary.org/obo/HP_0012530', 'lbl': 'Abnormal number of dense granules', 'desc': 'label: Abnormal number of dense granules\ndefinition : A deviation from the normal count of dense granules per thrombocyte.\nsynonyms :\n'}


{'id': 'HP_0012531', 'url': 'http://purl.obolibrary.org/obo/HP_0012531', 'lbl': 'Pain', 'desc': 'label: Pain\ndefinition : An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.\nsynonyms :Pain\n'}


{'id': 'HP_0012532', 'url': 'http://purl.obolibrary.org/obo/HP_0012532', 'lbl': 'Chronic pain', 'desc': 'label: Chronic pain\ndefinition : Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months.\nsynonyms :Chronic pain; Long-lasting pain\n'}


{'id': 'HP_0012533', 'url': 'http://purl.obolibrary.org/obo/HP_0012533', 'lbl': 'Allodynia', 'desc': 'label: Allodynia\ndefinition : Pain due to a stimulus that does not normally provoke pain.\nsynonyms :\n'}


{'id': 'HP_0012534', 'url': 'http://purl.obolibrary.org/obo/HP_0012534', 'lbl': 'Dysesthesia', 'desc': 'label: Dysesthesia\ndefinition : Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds.\nsynonyms :Dysaesthesia; Hyperalgesia; Hyperpathia; Dysesthesias\n'}


{'id': 'HP_0012535', 'url': 'http://purl.obolibrary.org/obo/HP_0012535', 'lbl': 'Abnormal synaptic transmission', 'desc': 'label: Abnormal synaptic transmission\ndefinition : An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process.\nsynonyms :Abnormality of neurotransmitter metabolism\n'}


{'id': 'HP_0012536', 'url': 'http://purl.obolibrary.org/obo/HP_0012536', 'lbl': 'Maternal anticardiolipin antibody positive', 'desc': 'label: Maternal anticardiolipin antibody positive\ndefinition : The presence of circulating autoantibodies to anticardiolipin in the mother.\nsynonyms :\n'}


{'id': 'HP_0012537', 'url': 'http://purl.obolibrary.org/obo/HP_0012537', 'lbl': 'Food intolerance', 'desc': 'label: Food intolerance\ndefinition : A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.\nsynonyms :Food intolerance; Non-allergic food hypersensitivity\n'}


{'id': 'HP_0012538', 'url': 'http://purl.obolibrary.org/obo/HP_0012538', 'lbl': 'Gluten intolerance', 'desc': 'label: Gluten intolerance\ndefinition : A detrimental reaction to the presence of gluten in food, which may include abdominal pain, fatigue, headaches and paresthesia, or celiac disease.\nsynonyms :Gluten intolerance; Gluten sensitivity\n'}


{'id': 'HP_0012539', 'url': 'http://purl.obolibrary.org/obo/HP_0012539', 'lbl': 'Non-Hodgkin lymphoma', 'desc': 'label: Non-Hodgkin lymphoma\ndefinition : A type of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells.\nsynonyms :\n'}


{'id': 'HP_0012540', 'url': 'http://purl.obolibrary.org/obo/HP_0012540', 'lbl': 'Axillary epidermoid cyst', 'desc': 'label: Axillary epidermoid cyst\ndefinition : An epidermoid cyst in the armpit.\nsynonyms :Armpit cyst\n'}


{'id': 'HP_0012541', 'url': 'http://purl.obolibrary.org/obo/HP_0012541', 'lbl': 'Cephalohematoma', 'desc': 'label: Cephalohematoma\ndefinition : Hemorrhage between the skull and periosteum of a newborn resulting from rupture of blood vessels that cross the periosteum.\nsynonyms :Cephalohaematoma\n'}


{'id': 'HP_0012542', 'url': 'http://purl.obolibrary.org/obo/HP_0012542', 'lbl': 'Onychauxis', 'desc': 'label: Onychauxis\ndefinition : Thickened nails without deformity.\nsynonyms :\n'}


{'id': 'HP_0012543', 'url': 'http://purl.obolibrary.org/obo/HP_0012543', 'lbl': 'Hemosiderinuria', 'desc': 'label: Hemosiderinuria\ndefinition : The presence of hemosiderin in the urine.\nsynonyms :\n'}


{'id': 'HP_0012544', 'url': 'http://purl.obolibrary.org/obo/HP_0012544', 'lbl': 'Elevated circulating aldolase concentration', 'desc': 'label: Elevated circulating aldolase concentration\ndefinition : Concentration of fructose 1,6-bisphosphate aldolase in the blood circulation above the upper limit of normal.\nsynonyms :Elevated aldolase level\n'}


{'id': 'HP_0012545', 'url': 'http://purl.obolibrary.org/obo/HP_0012545', 'lbl': 'Reduced circulating aldolase concentration', 'desc': 'label: Reduced circulating aldolase concentration\ndefinition : Concentration of fructose 1,6-bisphosphate aldolase in the blood circulation below the lower limit of normal.\nsynonyms :Reduced aldolase level\n'}


{'id': 'HP_0012546', 'url': 'http://purl.obolibrary.org/obo/HP_0012546', 'lbl': 'Skewed maternal X inactivation', 'desc': 'label: Skewed maternal X inactivation\ndefinition : A deviation from equal (50%) inactivation of each parental X chromosome in maternal cells.\nsynonyms :\n'}


{'id': 'HP_0012547', 'url': 'http://purl.obolibrary.org/obo/HP_0012547', 'lbl': 'Abnormal involuntary eye movements', 'desc': 'label: Abnormal involuntary eye movements\ndefinition : Anomalous movements of the eyes that occur without the subject wanting them to happen.\nsynonyms :\n'}


{'id': 'HP_0012548', 'url': 'http://purl.obolibrary.org/obo/HP_0012548', 'lbl': 'Fatty replacement of skeletal muscle', 'desc': 'label: Fatty replacement of skeletal muscle\ndefinition : Muscle fibers degeneration resulting in fatty replacement of skeletal muscle fibers\nsynonyms :Skeletal muscle fatty infiltration\n'}


{'id': 'HP_0012549', 'url': 'http://purl.obolibrary.org/obo/HP_0012549', 'lbl': 'Conjunctival lipoma', 'desc': 'label: Conjunctival lipoma\ndefinition : A lipoma (a benign tumor composed of adipose tissue) located in the conjunctiva.\nsynonyms :\n'}


{'id': 'HP_0012550', 'url': 'http://purl.obolibrary.org/obo/HP_0012550', 'lbl': 'Colonic varices', 'desc': 'label: Colonic varices\ndefinition : The presence of varices (enlarged and convoluted blood vessels) in the colon.\nsynonyms :\n'}


{'id': 'HP_0012551', 'url': 'http://purl.obolibrary.org/obo/HP_0012551', 'lbl': 'Absent neutrophil specific granules', 'desc': 'label: Absent neutrophil specific granules\ndefinition : Lack of specific granules in neutrophils.\nsynonyms :\n'}


{'id': 'HP_0012552', 'url': 'http://purl.obolibrary.org/obo/HP_0012552', 'lbl': 'Increased neutrophil nuclear projections', 'desc': 'label: Increased neutrophil nuclear projections\ndefinition : Presence of an elevated number of projections from nuclei of neutrophils. These projections can have the shape of hooks, tags, or clubs.\nsynonyms :\n'}


{'id': 'HP_0012553', 'url': 'http://purl.obolibrary.org/obo/HP_0012553', 'lbl': 'Hypoplastic thumbnail', 'desc': 'label: Hypoplastic thumbnail\ndefinition : A thumbnail that is diminished in length and width, i.e., underdeveloped thumb nail.\nsynonyms :Small thumbnail; Underdeveloped thumbnail\n'}


{'id': 'HP_0012554', 'url': 'http://purl.obolibrary.org/obo/HP_0012554', 'lbl': 'Absent thumbnail', 'desc': 'label: Absent thumbnail\ndefinition : Absence of thumb nail.\nsynonyms :\n'}


{'id': 'HP_0012555', 'url': 'http://purl.obolibrary.org/obo/HP_0012555', 'lbl': 'Absent nail of hallux', 'desc': 'label: Absent nail of hallux\ndefinition : Absent nail of big toe.\nsynonyms :Absent big toe nail; Absent nail of big toe\n'}


{'id': 'HP_0012556', 'url': 'http://purl.obolibrary.org/obo/HP_0012556', 'lbl': 'Hyperbeta-alaninemia', 'desc': 'label: Hyperbeta-alaninemia\ndefinition : Increased concentration of beta-alanine in the blood.\nsynonyms :High blood beta-alanine levels; Hyperbetaalaninemia\n'}


{'id': 'HP_0012557', 'url': 'http://purl.obolibrary.org/obo/HP_0012557', 'lbl': 'EEG with centrotemporal focal spike waves', 'desc': 'label: EEG with centrotemporal focal spike waves\ndefinition : EEG with focal sharp transient waves in the centrotemporal region of the brain (also known as the central sulcus), i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.\nsynonyms :\n'}


{'id': 'HP_0012558', 'url': 'http://purl.obolibrary.org/obo/HP_0012558', 'lbl': 'Abnormal T3/T4 ratio', 'desc': 'label: Abnormal T3/T4 ratio\ndefinition : A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that deviates from normal.\nsynonyms :\n'}


{'id': 'HP_0012559', 'url': 'http://purl.obolibrary.org/obo/HP_0012559', 'lbl': 'Increased T3/T4 ratio', 'desc': 'label: Increased T3/T4 ratio\ndefinition : A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is higher than normal.\nsynonyms :\n'}


{'id': 'HP_0012560', 'url': 'http://purl.obolibrary.org/obo/HP_0012560', 'lbl': 'Decreased T3/T4 ratio', 'desc': 'label: Decreased T3/T4 ratio\ndefinition : A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is lower than normal.\nsynonyms :\n'}


{'id': 'HP_0012561', 'url': 'http://purl.obolibrary.org/obo/HP_0012561', 'lbl': 'Unicuspid aortic valve', 'desc': 'label: Unicuspid aortic valve\ndefinition : The presence of an aortic valve with one instead of the normal three cusps (flaps).\nsynonyms :\n'}


{'id': 'HP_0012562', 'url': 'http://purl.obolibrary.org/obo/HP_0012562', 'lbl': 'Premature epimetaphyseal fusion in hand', 'desc': 'label: Premature epimetaphyseal fusion in hand\ndefinition : Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the hand, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.\nsynonyms :\n'}


{'id': 'HP_0012563', 'url': 'http://purl.obolibrary.org/obo/HP_0012563', 'lbl': 'Premature epimetaphyseal fusion in foot', 'desc': 'label: Premature epimetaphyseal fusion in foot\ndefinition : Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the foot, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.\nsynonyms :\n'}


{'id': 'HP_0012564', 'url': 'http://purl.obolibrary.org/obo/HP_0012564', 'lbl': 'Premature epimetaphyseal fusion in tibia', 'desc': 'label: Premature epimetaphyseal fusion in tibia\ndefinition : Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the tibia, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.\nsynonyms :\n'}


{'id': 'HP_0012565', 'url': 'http://purl.obolibrary.org/obo/HP_0012565', 'lbl': 'Premature epimetaphyseal fusion in fibula', 'desc': 'label: Premature epimetaphyseal fusion in fibula\ndefinition : Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the fibula, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.\nsynonyms :\n'}


{'id': 'HP_0012566', 'url': 'http://purl.obolibrary.org/obo/HP_0012566', 'lbl': 'Premature epimetaphyseal fusion in radius', 'desc': 'label: Premature epimetaphyseal fusion in radius\ndefinition : Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the radius, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.\nsynonyms :\n'}


{'id': 'HP_0012567', 'url': 'http://purl.obolibrary.org/obo/HP_0012567', 'lbl': 'Premature epimetaphyseal fusion in ulna', 'desc': 'label: Premature epimetaphyseal fusion in ulna\ndefinition : Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the ulna, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.\nsynonyms :\n'}


{'id': 'HP_0012568', 'url': 'http://purl.obolibrary.org/obo/HP_0012568', 'lbl': 'Lower eyelid edema', 'desc': 'label: Lower eyelid edema\ndefinition : Edema in the region of the Lower eyelid.\nsynonyms :Cellulitis of lower eyelid; Fullness of lower eyelid; Lower eyelid oedema; Puffiness of lower eyelid; Swelling of lower eyelid\n'}


{'id': 'HP_0012569', 'url': 'http://purl.obolibrary.org/obo/HP_0012569', 'lbl': 'Delayed menarche', 'desc': 'label: Delayed menarche\ndefinition : First period after the age of 15 years.\nsynonyms :Delayed start of first period\n'}


{'id': 'HP_0012570', 'url': 'http://purl.obolibrary.org/obo/HP_0012570', 'lbl': 'Synovial sarcoma', 'desc': 'label: Synovial sarcoma\ndefinition : A type of mesenchymal tissue cell tumor that exhibits epithelial differentiation, which most frequently arises in the extremities.\nsynonyms :Malignant synovioma\n'}


{'id': 'HP_0012571', 'url': 'http://purl.obolibrary.org/obo/HP_0012571', 'lbl': 'Ureter fissus', 'desc': 'label: Ureter fissus\ndefinition : A partial duplication of the ureter where the duplicated ureters fuse to a single ureter before their insertion into the bladder.\nsynonyms :Partially duplicated ureter\n'}


{'id': 'HP_0012572', 'url': 'http://purl.obolibrary.org/obo/HP_0012572', 'lbl': 'Ureter duplex', 'desc': 'label: Ureter duplex\ndefinition : A complete duplication of the ureter, where the duplicated ureters have separate insertions into the bladder.\nsynonyms :\n'}


{'id': 'HP_0012573', 'url': 'http://purl.obolibrary.org/obo/HP_0012573', 'lbl': 'Global proximal tubulopathy', 'desc': 'label: Global proximal tubulopathy\ndefinition : A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption with bicarbonate loss and resulting acidosis.\nsynonyms :\n'}


{'id': 'HP_0012574', 'url': 'http://purl.obolibrary.org/obo/HP_0012574', 'lbl': 'Mesangial hypercellularity', 'desc': 'label: Mesangial hypercellularity\ndefinition : Increased numbers of mesangial cells per glomerulus, defined as more than 3 nuclei fully surrounded by matrix in one or more mesangial areas, not including perihilar region, on a standard 3-micron-thick tissue section, best evaluated on periodic acid-Schiff (PAS) stain.\nsynonyms :Mesangial proliferation\n'}


{'id': 'HP_0012575', 'url': 'http://purl.obolibrary.org/obo/HP_0012575', 'lbl': 'Abnormal nephron morphology', 'desc': 'label: Abnormal nephron morphology\ndefinition : A structural anomaly of the nephron.\nsynonyms :Abnormality of the nephron\n'}


{'id': 'HP_0012576', 'url': 'http://purl.obolibrary.org/obo/HP_0012576', 'lbl': 'Glomerular C3 deposition', 'desc': 'label: Glomerular C3 deposition\ndefinition : The presence of complement 3 deposits in the glomerulus.\nsynonyms :Renal C3 deposition; C3 nephropathy\n'}


{'id': 'HP_0012577', 'url': 'http://purl.obolibrary.org/obo/HP_0012577', 'lbl': 'Thin glomerular basement membrane', 'desc': 'label: Thin glomerular basement membrane\ndefinition : Decreased thickness of the glomerular basement membrane (GBM), measured from endothelial to visceral epithelial plasma membrane and mainly attributable to a decrease in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations less than that of the normal mean GBM thickness for health age- and sex matched individuals. May be focal or diffuse, although the term thin GBMs generally implies thinning of over 50% of GBMs.\nsynonyms :\n'}


{'id': 'HP_0012578', 'url': 'http://purl.obolibrary.org/obo/HP_0012578', 'lbl': 'Membranous nephropathy', 'desc': 'label: Membranous nephropathy\ndefinition : A type of glomerulonephropathy characterized by thickening of the basement membrane and deposition of immune complexes in the subepithelial space.\nsynonyms :Membranous glomerulonephritis\n'}


{'id': 'HP_0012579', 'url': 'http://purl.obolibrary.org/obo/HP_0012579', 'lbl': 'Minimal change glomerulonephritis', 'desc': 'label: Minimal change glomerulonephritis\ndefinition : The presence of minimal changes visible by light microscopy but flattened and fused podocyte foot processes on electron microscopy in a person with nephrotic range proteinuria.\nsynonyms :Minimal change disease; Minimal change nephropathy\n'}


{'id': 'HP_0012580', 'url': 'http://purl.obolibrary.org/obo/HP_0012580', 'lbl': 'Calcium phosphate nephrolithiasis', 'desc': 'label: Calcium phosphate nephrolithiasis\ndefinition : The presence of calcium- and phosphate-containing calculi (stones) in the kidneys.\nsynonyms :Ca phosphate nephrolithiasis; Ca phosphate urolithiasis; Ca2+ phosphate nephrolitiasis; Ca2+ phosphate urolithiasis; Calcium phosphate urolithiasis\n'}


{'id': 'HP_0012581', 'url': 'http://purl.obolibrary.org/obo/HP_0012581', 'lbl': 'Simple renal cyst', 'desc': 'label: Simple renal cyst\ndefinition : An isolated cyst of the kidney.\nsynonyms :Simple kidney cyst; Solitary renal cyst; single cortical cyst\n'}


{'id': 'HP_0012582', 'url': 'http://purl.obolibrary.org/obo/HP_0012582', 'lbl': 'Bilateral renal dysplasia', 'desc': 'label: Bilateral renal dysplasia\ndefinition : A bilateral form of developmental dysplasia of the kidney.\nsynonyms :\n'}


{'id': 'HP_0012583', 'url': 'http://purl.obolibrary.org/obo/HP_0012583', 'lbl': 'Unilateral renal hypoplasia', 'desc': 'label: Unilateral renal hypoplasia\ndefinition : One sided hypoplasia of the kidney.\nsynonyms :Small kidney on one side; Underdeveloped kidney on one side\n'}


{'id': 'HP_0012584', 'url': 'http://purl.obolibrary.org/obo/HP_0012584', 'lbl': 'Bilateral renal hypoplasia', 'desc': 'label: Bilateral renal hypoplasia\ndefinition : Two sided hypoplasia of the kidney.\nsynonyms :\n'}


{'id': 'HP_0012585', 'url': 'http://purl.obolibrary.org/obo/HP_0012585', 'lbl': 'Renal atrophy', 'desc': 'label: Renal atrophy\ndefinition : Atrophy of the kidney.\nsynonyms :Kidney degeneration\n'}


{'id': 'HP_0012586', 'url': 'http://purl.obolibrary.org/obo/HP_0012586', 'lbl': 'Bilateral renal atrophy', 'desc': 'label: Bilateral renal atrophy\ndefinition : A two-sided form of atrophy of the kidney.\nsynonyms :Bilateral kidney degeneration\n'}


{'id': 'HP_0012587', 'url': 'http://purl.obolibrary.org/obo/HP_0012587', 'lbl': 'Macroscopic hematuria', 'desc': 'label: Macroscopic hematuria\ndefinition : Hematuria that is visible upon inspection of the urine.\nsynonyms :Bloody urine; Gross hematuria\n'}


{'id': 'HP_0012588', 'url': 'http://purl.obolibrary.org/obo/HP_0012588', 'lbl': 'Steroid-resistant nephrotic syndrome', 'desc': 'label: Steroid-resistant nephrotic syndrome\ndefinition : A form of nephrotic syndrome that does not respond to treatment with steroid medication, defined as persistent proteinuria despite 60mg/m2 or 2mg/kg for 8 weeks, after insuring no infection or non-adherence to medication.\nsynonyms :SRNS\n'}


{'id': 'HP_0012589', 'url': 'http://purl.obolibrary.org/obo/HP_0012589', 'lbl': 'Multidrug-resistant nephrotic syndrome', 'desc': 'label: Multidrug-resistant nephrotic syndrome\ndefinition : A form of nephrotic syndrome that does not respond to any immunosuppresive treatment.\nsynonyms :\n'}


{'id': 'HP_0012590', 'url': 'http://purl.obolibrary.org/obo/HP_0012590', 'lbl': 'Abnormal urine output', 'desc': 'label: Abnormal urine output\ndefinition : An abnormal amount of urine production.\nsynonyms :\n'}


{'id': 'HP_0012591', 'url': 'http://purl.obolibrary.org/obo/HP_0012591', 'lbl': 'Abnormal urinary electrolyte concentration', 'desc': 'label: Abnormal urinary electrolyte concentration\ndefinition : An abnormality in the concentration of electrolytes in the urine.\nsynonyms :Urinary electrolyte imbalance\n'}


{'id': 'HP_0012592', 'url': 'http://purl.obolibrary.org/obo/HP_0012592', 'lbl': 'Albuminuria', 'desc': 'label: Albuminuria\ndefinition : Increased concentration of albumin in the urine.\nsynonyms :\n'}


{'id': 'HP_0012593', 'url': 'http://purl.obolibrary.org/obo/HP_0012593', 'lbl': 'Nephrotic range proteinuria', 'desc': 'label: Nephrotic range proteinuria\ndefinition : Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children.\nsynonyms :\n'}


{'id': 'HP_0012594', 'url': 'http://purl.obolibrary.org/obo/HP_0012594', 'lbl': 'Moderate albuminuria', 'desc': 'label: Moderate albuminuria\ndefinition : The presence of moderately increased concentrations of albumin in the urine, defined as and albumin-creatinine ratio (ACR) of 30 to 299 mg/gm (3.4 to 34 mg/mmol).\nsynonyms :High urine albumin levels; Microalbuminuria\n'}


{'id': 'HP_0012595', 'url': 'http://purl.obolibrary.org/obo/HP_0012595', 'lbl': 'Mild proteinuria', 'desc': 'label: Mild proteinuria\ndefinition : Mildly increased levels of protein in the urine (150-500 mg per day in adults).\nsynonyms :\n'}


{'id': 'HP_0012596', 'url': 'http://purl.obolibrary.org/obo/HP_0012596', 'lbl': 'Moderate proteinuria', 'desc': 'label: Moderate proteinuria\ndefinition : Moderately increased levels of protein in the urine (500-1000 mg per day in adults).\nsynonyms :\n'}


{'id': 'HP_0012597', 'url': 'http://purl.obolibrary.org/obo/HP_0012597', 'lbl': 'Heavy proteinuria', 'desc': 'label: Heavy proteinuria\ndefinition : Severely increased levels of protein in the urine (1000-3000 mg per day in adults).\nsynonyms :Severly high blood protein levels\n'}


{'id': 'HP_0012598', 'url': 'http://purl.obolibrary.org/obo/HP_0012598', 'lbl': 'Abnormal urine potassium concentration', 'desc': 'label: Abnormal urine potassium concentration\ndefinition : An abnormal concentration of potassium(1+) in the urine.\nsynonyms :Abnormal urine K concentration\n'}


{'id': 'HP_0012599', 'url': 'http://purl.obolibrary.org/obo/HP_0012599', 'lbl': 'Abnormal urine phosphate concentration', 'desc': 'label: Abnormal urine phosphate concentration\ndefinition : An abnormal phosphate concentration in the urine.\nsynonyms :\n'}


{'id': 'HP_0012600', 'url': 'http://purl.obolibrary.org/obo/HP_0012600', 'lbl': 'Abnormal urine chloride concentration', 'desc': 'label: Abnormal urine chloride concentration\ndefinition : An abnormal concentration of chloride in the urine.\nsynonyms :Abnormal urine Cl concentration; Abnormal urine Cl- concentration\n'}


{'id': 'HP_0012601', 'url': 'http://purl.obolibrary.org/obo/HP_0012601', 'lbl': 'Hypochloriduria', 'desc': 'label: Hypochloriduria\ndefinition : An decreased concentration of chloride in the urine.\nsynonyms :Decreased urinary chloride; Low urine chloride levels\n'}


{'id': 'HP_0012602', 'url': 'http://purl.obolibrary.org/obo/HP_0012602', 'lbl': 'Renal chloride wasting', 'desc': 'label: Renal chloride wasting\ndefinition : High urine chloride in the presence of hypochloridemia.\nsynonyms :Kidney chloride wasting; Renal Cl wasting; Renal Cl- wasting\n'}


{'id': 'HP_0012603', 'url': 'http://purl.obolibrary.org/obo/HP_0012603', 'lbl': 'Abnormal urine sodium concentration', 'desc': 'label: Abnormal urine sodium concentration\ndefinition : An abnormal concentration of sodium in the urine.\nsynonyms :Abnormal urine Na concentration; Abnormal urine Na+ levels\n'}


{'id': 'HP_0012604', 'url': 'http://purl.obolibrary.org/obo/HP_0012604', 'lbl': 'Hyponatriuria', 'desc': 'label: Hyponatriuria\ndefinition : An abnormally decreased sodium concentration in the urine.\nsynonyms :Low urine sodium levels\n'}


{'id': 'HP_0012605', 'url': 'http://purl.obolibrary.org/obo/HP_0012605', 'lbl': 'Hypernatriuria', 'desc': 'label: Hypernatriuria\ndefinition : An increased concentration of sodium(1+) in the urine.\nsynonyms :Increased urinary sodium\n'}


{'id': 'HP_0012606', 'url': 'http://purl.obolibrary.org/obo/HP_0012606', 'lbl': 'Renal sodium wasting', 'desc': 'label: Renal sodium wasting\ndefinition : An abnormally increased sodium concentration in the urine in the presence of hyponatremia.\nsynonyms :Kidney sodium wasting; Renal Na wasting; Renal Na+ wasting\n'}


{'id': 'HP_0012607', 'url': 'http://purl.obolibrary.org/obo/HP_0012607', 'lbl': 'Abnormal urine magnesium concentration', 'desc': 'label: Abnormal urine magnesium concentration\ndefinition : An abnormal concentration of magnesium the urine.\nsynonyms :Abnormal urine magnesium concentration\n'}


{'id': 'HP_0012608', 'url': 'http://purl.obolibrary.org/obo/HP_0012608', 'lbl': 'Hypermagnesiuria', 'desc': 'label: Hypermagnesiuria\ndefinition : An increased concentration of magnesium the urine.\nsynonyms :\n'}


{'id': 'HP_0012609', 'url': 'http://purl.obolibrary.org/obo/HP_0012609', 'lbl': 'Hypomagnesiuria', 'desc': 'label: Hypomagnesiuria\ndefinition : An decreased concentration of magnesium the urine.\nsynonyms :Decreased urine magnesium; Low urine magnesium levels\n'}


{'id': 'HP_0012610', 'url': 'http://purl.obolibrary.org/obo/HP_0012610', 'lbl': 'Abnormality of urinary uric acid level', 'desc': 'label: Abnormality of urinary uric acid level\ndefinition : Abnormal amount of urate in the urine.\nsynonyms :\n'}


{'id': 'HP_0012611', 'url': 'http://purl.obolibrary.org/obo/HP_0012611', 'lbl': 'obsolete Increased urinary urate', 'desc': 'label: obsolete Increased urinary urate\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0012612', 'url': 'http://purl.obolibrary.org/obo/HP_0012612', 'lbl': 'Abnormal urinary sulfate concentration', 'desc': 'label: Abnormal urinary sulfate concentration\ndefinition : Abnormal concentration of sulfate in the urine.\nsynonyms :Abnormal urinary sulphate concentration\n'}


{'id': 'HP_0012613', 'url': 'http://purl.obolibrary.org/obo/HP_0012613', 'lbl': 'Increased urinary sulfate', 'desc': 'label: Increased urinary sulfate\ndefinition : Elevated concentration of SO4(2-), i.e., sulfate, in the urine.\nsynonyms :Increased urinary sulphate\n'}


{'id': 'HP_0012614', 'url': 'http://purl.obolibrary.org/obo/HP_0012614', 'lbl': 'Abnormal urine cytology', 'desc': 'label: Abnormal urine cytology\ndefinition : An anomalous finding in the examination of the urine for cells.\nsynonyms :\n'}


{'id': 'HP_0012615', 'url': 'http://purl.obolibrary.org/obo/HP_0012615', 'lbl': 'Cylindruria', 'desc': 'label: Cylindruria\ndefinition : The presence of renal casts (cylindrical, cigar-shaped structures produced by the kidney in certain disease states) in the urine.\nsynonyms :Urinary casts\n'}


{'id': 'HP_0012616', 'url': 'http://purl.obolibrary.org/obo/HP_0012616', 'lbl': 'Leukocyte cylindruria', 'desc': 'label: Leukocyte cylindruria\ndefinition : Presence of leukocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine.\nsynonyms :White blood cell casts\n'}


{'id': 'HP_0012617', 'url': 'http://purl.obolibrary.org/obo/HP_0012617', 'lbl': 'Erythrocyte cylindruria', 'desc': 'label: Erythrocyte cylindruria\ndefinition : Presence of erythrocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine.\nsynonyms :Red blood cell casts; Urinary erythrocyte cast\n'}


{'id': 'HP_0012618', 'url': 'http://purl.obolibrary.org/obo/HP_0012618', 'lbl': 'Urachal cyst', 'desc': 'label: Urachal cyst\ndefinition : A cyst located along the allantois canal.\nsynonyms :\n'}


{'id': 'HP_0012619', 'url': 'http://purl.obolibrary.org/obo/HP_0012619', 'lbl': 'Multiple bladder diverticula', 'desc': 'label: Multiple bladder diverticula\ndefinition : Presence of a many diverticula (sac or pouch) in the wall of the urinary bladder.\nsynonyms :Multiple pouches in bladder wall\n'}


{'id': 'HP_0012620', 'url': 'http://purl.obolibrary.org/obo/HP_0012620', 'lbl': 'Cloacal abnormality', 'desc': 'label: Cloacal abnormality\ndefinition : A developmental anomaly associated with the failure of rectum, vagina, and bladder to separate.\nsynonyms :\n'}


{'id': 'HP_0012621', 'url': 'http://purl.obolibrary.org/obo/HP_0012621', 'lbl': 'Persistent cloaca', 'desc': 'label: Persistent cloaca\ndefinition : Developmental anomaly in which the vagina, bladder, and rectum fuse resulting in a common channel.\nsynonyms :Cloacogenic bladder\n'}


{'id': 'HP_0012622', 'url': 'http://purl.obolibrary.org/obo/HP_0012622', 'lbl': 'Chronic kidney disease', 'desc': 'label: Chronic kidney disease\ndefinition : Functional anomaly of the kidney persisting for at least three months.\nsynonyms :Chronic kidney disease; Loss of renal function; Progressive renal failure; Progressive renal insufficiency; Renal failure, progressive; Renal insufficiency, progressive\n'}


{'id': 'HP_0012623', 'url': 'http://purl.obolibrary.org/obo/HP_0012623', 'lbl': 'Stage 1 chronic kidney disease', 'desc': 'label: Stage 1 chronic kidney disease\ndefinition : A type of chronic kidney disease with normal or increased glomerular filtration rate (GFR at least 90 mL/min/1.73 m2).\nsynonyms :\n'}


{'id': 'HP_0012624', 'url': 'http://purl.obolibrary.org/obo/HP_0012624', 'lbl': 'Stage 2 chronic kidney disease', 'desc': 'label: Stage 2 chronic kidney disease\ndefinition : A type of chronic kidney disease with mildly reduced glomerular filtration rate (GFR 60-89 mL/min/1.73 m2).\nsynonyms :\n'}


{'id': 'HP_0012625', 'url': 'http://purl.obolibrary.org/obo/HP_0012625', 'lbl': 'Stage 3 chronic kidney disease', 'desc': 'label: Stage 3 chronic kidney disease\ndefinition : A type of chronic kidney disease with moderately reduced glomerular filtration rate (GFR 30-59 mL/min/1.73 m2).\nsynonyms :\n'}


{'id': 'HP_0012626', 'url': 'http://purl.obolibrary.org/obo/HP_0012626', 'lbl': 'Stage 4 chronic kidney disease', 'desc': 'label: Stage 4 chronic kidney disease\ndefinition : A type of chronic kidney disease with severely reduced glomerular filtration rate (GFR 15-29 mL/min/1.73 m2).\nsynonyms :Stage 4 chronic kidney disease\n'}


{'id': 'HP_0012627', 'url': 'http://purl.obolibrary.org/obo/HP_0012627', 'lbl': 'Pseudoexfoliation', 'desc': 'label: Pseudoexfoliation\ndefinition : Deposition of fibrillar material that can be found on all anterior segment structures bathed by aqueous humor.\nsynonyms :\n'}


{'id': 'HP_0012628', 'url': 'http://purl.obolibrary.org/obo/HP_0012628', 'lbl': 'Abnormal suspensory ligament of lens morphology', 'desc': "label: Abnormal suspensory ligament of lens morphology\ndefinition : An anomaly of the suspensory ligament of lens, also known as the ciliary zonule. These ligaments represent a series of fibers connecting the ciliary body and lens of the eye, holding the lens in place.\nsynonyms :Abnormality of the suspensory ligament of lens; Abnormality of zinn's membrane; Ciliary zonule abnormality; Zonule of zinn abnormality\n"}


{'id': 'HP_0012629', 'url': 'http://purl.obolibrary.org/obo/HP_0012629', 'lbl': 'Phakodonesis', 'desc': 'label: Phakodonesis\ndefinition : Tremulousness (trembling) of the lens of the eye.\nsynonyms :Phacodonesis; Trembling eye lens\n'}


{'id': 'HP_0012630', 'url': 'http://purl.obolibrary.org/obo/HP_0012630', 'lbl': 'Abnormal trabecular meshwork morphology', 'desc': 'label: Abnormal trabecular meshwork morphology\ndefinition : An anomaly of the trabecular meshwork, which is the porelike structure surrounding the entire circumference of the anterior chamber at the base of the cornea and near the ciliary body. The trabecular mesh work is responsible for draining the aqueous humor into the canal of Schlemm.\nsynonyms :Abnormality of the trabecular meshwork\n'}


{'id': 'HP_0012631', 'url': 'http://purl.obolibrary.org/obo/HP_0012631', 'lbl': 'Pigment deposition in the trabecular meshwork', 'desc': 'label: Pigment deposition in the trabecular meshwork\ndefinition : Accumulation of abnormal amounts of pigment within the trabecular meshwork.\nsynonyms :\n'}


{'id': 'HP_0012632', 'url': 'http://purl.obolibrary.org/obo/HP_0012632', 'lbl': 'Abnormal intraocular pressure', 'desc': 'label: Abnormal intraocular pressure\ndefinition : An anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye.\nsynonyms :Abnormal eye pressure; Abnormal intraocular pressure\n'}


{'id': 'HP_0012633', 'url': 'http://purl.obolibrary.org/obo/HP_0012633', 'lbl': 'Asymmetry of intraocular pressure', 'desc': 'label: Asymmetry of intraocular pressure\ndefinition : A difference in the amount of intraocular pressure in the right and left eye.\nsynonyms :\n'}


{'id': 'HP_0012634', 'url': 'http://purl.obolibrary.org/obo/HP_0012634', 'lbl': 'Iris pigment dispersion', 'desc': 'label: Iris pigment dispersion\ndefinition : Shedding of the pigment granules that normally adhere to the back of the iris into the aqueous humor.\nsynonyms :\n'}


{'id': 'HP_0012635', 'url': 'http://purl.obolibrary.org/obo/HP_0012635', 'lbl': 'Iris hypoperfusion', 'desc': 'label: Iris hypoperfusion\ndefinition : Reduction in the amount of blood flow to the iris.\nsynonyms :\n'}


{'id': 'HP_0012636', 'url': 'http://purl.obolibrary.org/obo/HP_0012636', 'lbl': 'Retinal vein occlusion', 'desc': 'label: Retinal vein occlusion\ndefinition : Blockage of the retinal vein.\nsynonyms :\n'}


{'id': 'HP_0012637', 'url': 'http://purl.obolibrary.org/obo/HP_0012637', 'lbl': 'Renal calcium wasting', 'desc': 'label: Renal calcium wasting\ndefinition : High urine calcium in the presence of hypocalcemia.\nsynonyms :Kidney Ca wasting; Kidney Ca2+ wasting; Kidney calcium wasting; Renal Ca wasting; Renal Ca2+ wasting\n'}


{'id': 'HP_0012638', 'url': 'http://purl.obolibrary.org/obo/HP_0012638', 'lbl': 'Abnormal nervous system physiology', 'desc': 'label: Abnormal nervous system physiology\ndefinition : A functional anomaly of the nervous system.\nsynonyms :Abnormality of nervous system physiology\n'}


{'id': 'HP_0012639', 'url': 'http://purl.obolibrary.org/obo/HP_0012639', 'lbl': 'Abnormal nervous system morphology', 'desc': 'label: Abnormal nervous system morphology\ndefinition : A structural anomaly of the nervous system.\nsynonyms :Abnormal shape of nervous system; Abnormality of nervous system morphology\n'}


{'id': 'HP_0012640', 'url': 'http://purl.obolibrary.org/obo/HP_0012640', 'lbl': 'Abnormality of intracranial pressure', 'desc': 'label: Abnormality of intracranial pressure\ndefinition : A deviation from the norm of the intracranial pressure.\nsynonyms :\n'}


{'id': 'HP_0012641', 'url': 'http://purl.obolibrary.org/obo/HP_0012641', 'lbl': 'Decreased intracranial pressure', 'desc': 'label: Decreased intracranial pressure\ndefinition : A reduction of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid.\nsynonyms :Intracranial hypotension\n'}


{'id': 'HP_0012642', 'url': 'http://purl.obolibrary.org/obo/HP_0012642', 'lbl': 'Cerebellar agenesis', 'desc': 'label: Cerebellar agenesis\ndefinition : Cerebellar agenesis is defined by the near complete absence of cerebellar tissue with only remnants of the anterior vermis, flocculus, and/or middle cerebellar peduncles.\nsynonyms :\n'}


{'id': 'HP_0012643', 'url': 'http://purl.obolibrary.org/obo/HP_0012643', 'lbl': 'Foveal hypopigmentation', 'desc': 'label: Foveal hypopigmentation\ndefinition : Decreased amount of pigmentation in the fovea centralis.\nsynonyms :\n'}


{'id': 'HP_0012644', 'url': 'http://purl.obolibrary.org/obo/HP_0012644', 'lbl': 'Increased caudate lactate level', 'desc': 'label: Increased caudate lactate level\ndefinition : An elevated concentration of lactate in the caudate nucleus. This finding can be elicited by magnetic resonance spectroscopy imaging.\nsynonyms :\n'}


{'id': 'HP_0012645', 'url': 'http://purl.obolibrary.org/obo/HP_0012645', 'lbl': 'Enlarged peripheral nerve', 'desc': 'label: Enlarged peripheral nerve\ndefinition : Increase in size of a peripheral nerve. This finding can be appreciated by palpation along the axis of the nerve.\nsynonyms :Enlarged peripheral nerves\n'}


{'id': 'HP_0012646', 'url': 'http://purl.obolibrary.org/obo/HP_0012646', 'lbl': 'Retractile testis', 'desc': 'label: Retractile testis\ndefinition : A testis that is located at the upper scrotum or lower inguinal canal and that can be made to descend completely into the scrotum without resistance by manual reduction but returns to its original position by the cremasteric reflex.\nsynonyms :Retractile testicle\n'}


{'id': 'HP_0012647', 'url': 'http://purl.obolibrary.org/obo/HP_0012647', 'lbl': 'Abnormal inflammatory response', 'desc': 'label: Abnormal inflammatory response\ndefinition : Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.\nsynonyms :Abnormal inflammatory response\n'}


{'id': 'HP_0012648', 'url': 'http://purl.obolibrary.org/obo/HP_0012648', 'lbl': 'Decreased inflammatory response', 'desc': 'label: Decreased inflammatory response\ndefinition : An abnormal reduction in the inflammatory response to injury or infection.\nsynonyms :Decreased inflammatory response\n'}


{'id': 'HP_0012649', 'url': 'http://purl.obolibrary.org/obo/HP_0012649', 'lbl': 'Increased inflammatory response', 'desc': 'label: Increased inflammatory response\ndefinition : A abnormal increase in the inflammatory response to injury or infection.\nsynonyms :\n'}


{'id': 'HP_0012650', 'url': 'http://purl.obolibrary.org/obo/HP_0012650', 'lbl': 'Perisylvian polymicrogyria', 'desc': 'label: Perisylvian polymicrogyria\ndefinition : Polymicrogyria (an excessive number of small gyri or convolutions) that is maximal in perisylvian regions (the regions that surround the Sylvian fissures), which may be symmetric or asymmetric and may extend beyond perisylvian regions. The Sylvian fissures often extend posteriorly and superiorly.\nsynonyms :Frontoparietal polymicrogyria\n'}


{'id': 'HP_0012651', 'url': 'http://purl.obolibrary.org/obo/HP_0012651', 'lbl': 'Abasia', 'desc': 'label: Abasia\ndefinition : A severe form of gait ataxia such that an affected person cannot walk at all.\nsynonyms :\n'}


{'id': 'HP_0012652', 'url': 'http://purl.obolibrary.org/obo/HP_0012652', 'lbl': 'Exercise-induced asthma', 'desc': 'label: Exercise-induced asthma\ndefinition : Asthma attacks following exercise.\nsynonyms :Exercise-induced asthma\n'}


{'id': 'HP_0012653', 'url': 'http://purl.obolibrary.org/obo/HP_0012653', 'lbl': 'Status asthmaticus', 'desc': 'label: Status asthmaticus\ndefinition : Severe asthma unresponsive to repeated courses of beta-agonist therapy such as inhaled albuterol, levalbuterol, or subcutaneous epinephrine.\nsynonyms :Acute severe asthma\n'}


{'id': 'HP_0012654', 'url': 'http://purl.obolibrary.org/obo/HP_0012654', 'lbl': 'Abnormal CSF dopamine concentration', 'desc': 'label: Abnormal CSF dopamine concentration\ndefinition : Abnormal concentration of dopamine in the cerebrospinal fluid (CSF).\nsynonyms :Abnormal CSF dopamine level\n'}


{'id': 'HP_0012655', 'url': 'http://purl.obolibrary.org/obo/HP_0012655', 'lbl': 'Elevated CSF dopamine concentration', 'desc': 'label: Elevated CSF dopamine concentration\ndefinition : Increased concentration of dopamine in the cerebrospinal fluid (CSF).\nsynonyms :\n'}


{'id': 'HP_0012656', 'url': 'http://purl.obolibrary.org/obo/HP_0012656', 'lbl': 'Reduced CSF dopamine concentration', 'desc': 'label: Reduced CSF dopamine concentration\ndefinition : Decreased concentration of dopamine in the cerebrospinal fluid (CSF).\nsynonyms :\n'}


{'id': 'HP_0012657', 'url': 'http://purl.obolibrary.org/obo/HP_0012657', 'lbl': 'Abnormal brain positron emission tomography', 'desc': 'label: Abnormal brain positron emission tomography\ndefinition : A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain.\nsynonyms :Abnormal brain PET scan\n'}


{'id': 'HP_0012658', 'url': 'http://purl.obolibrary.org/obo/HP_0012658', 'lbl': 'Abnormal brain FDG positron emission tomography', 'desc': 'label: Abnormal brain FDG positron emission tomography\ndefinition : An anomaly detectable in [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans. Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity.\nsynonyms :Abnormal brain FDG PET scan\n'}


{'id': 'HP_0012659', 'url': 'http://purl.obolibrary.org/obo/HP_0012659', 'lbl': 'Prefrontal hypometabolism in FDG PET', 'desc': 'label: Prefrontal hypometabolism in FDG PET\ndefinition : Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the prefrontal cortex as measured by positron emission tomography (PET) brain scan.\nsynonyms :\n'}


{'id': 'HP_0012660', 'url': 'http://purl.obolibrary.org/obo/HP_0012660', 'lbl': 'Thalamic hypometabolism in FDG PET', 'desc': 'label: Thalamic hypometabolism in FDG PET\ndefinition : Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the thalamus as measured by positron emission tomography (PET) brain scan.\nsynonyms :\n'}


{'id': 'HP_0012661', 'url': 'http://purl.obolibrary.org/obo/HP_0012661', 'lbl': 'Hypothalamic hypometabolism in FDG PET', 'desc': 'label: Hypothalamic hypometabolism in FDG PET\ndefinition : Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the hypothalamus as measured by positron emission tomography (PET) brain scan.\nsynonyms :\n'}


{'id': 'HP_0012662', 'url': 'http://purl.obolibrary.org/obo/HP_0012662', 'lbl': 'Parietal hypometabolism in FDG PET', 'desc': 'label: Parietal hypometabolism in FDG PET\ndefinition : Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the parietal cortex as measured by positron emission tomography (PET) brain scan.\nsynonyms :\n'}


{'id': 'HP_0012663', 'url': 'http://purl.obolibrary.org/obo/HP_0012663', 'lbl': 'Mildly reduced left ventricular ejection fraction', 'desc': 'label: Mildly reduced left ventricular ejection fraction\ndefinition : A small reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at least 50 percent, and a mild reduction is defined as 40-49 percent.\nsynonyms :Mildly reduced ejection fraction\n'}