{'id': 'HP_0034221', 'url': 'http://purl.obolibrary.org/obo/HP_0034221', 'lbl': 'Abnormal temporal lobe morphology', 'desc': 'label: Abnormal temporal lobe morphology\ndefinition : An abnormal strcutural of the zone (lobe) of the cerebral cortex that is located inferior to the lateral fissure on other cerebral hemispheres.\nsynonyms :\n'}


{'id': 'HP_0034222', 'url': 'http://purl.obolibrary.org/obo/HP_0034222', 'lbl': 'Temporal lobe dysplasia', 'desc': 'label: Temporal lobe dysplasia\ndefinition : A developmental defect of the temporal lobe of the cerebral cortex that is characterized by prominent sulcations and radially directed gyrations.\nsynonyms :\n'}


{'id': 'HP_0034223', 'url': 'http://purl.obolibrary.org/obo/HP_0034223', 'lbl': 'Elevated umbilical artery pulsatility', 'desc': 'label: Elevated umbilical artery pulsatility\ndefinition : Human umbilical artery (UA) blood flow pulsatility measured by Doppler ultrasound is a widely used biomarker for the detection of elevated placental vascular resistance. Elevated UA pulsatility, which in the most extreme cases manifests as absent or even reversed end-diastolic velocity, is associated with intrauterine growth restriction (IUGR) and still-birth.\nsynonyms :Elevated umbilical artery Dopplers; Increased umbilical artery pulsatility index\n'}


{'id': 'HP_0034224', 'url': 'http://purl.obolibrary.org/obo/HP_0034224', 'lbl': 'Absent end-diastolic umbilical artery flow', 'desc': 'label: Absent end-diastolic umbilical artery flow\ndefinition : An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an absence of flow in the umbilical artery at the end of diastole.\nsynonyms :\n'}


{'id': 'HP_0034225', 'url': 'http://purl.obolibrary.org/obo/HP_0034225', 'lbl': 'Reversed end-diastolic umbilical artery flow', 'desc': 'label: Reversed end-diastolic umbilical artery flow\ndefinition : An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an reversal of flow in the umbilical artery at the end of diastole (i.e., backwards flow).\nsynonyms :\n'}


{'id': 'HP_0034226', 'url': 'http://purl.obolibrary.org/obo/HP_0034226', 'lbl': 'Champagne cork sign', 'desc': 'label: Champagne cork sign\ndefinition : Characteristic appearance of the chest and abdomen in the sagittal view on prenatal ultrasound when the chest is small and the abdomen protruding.\nsynonyms :\n'}


{'id': 'HP_0034227', 'url': 'http://purl.obolibrary.org/obo/HP_0034227', 'lbl': 'Aortic isthmus hypoplasia', 'desc': 'label: Aortic isthmus hypoplasia\ndefinition : A type of aortic arch hypoplasia whereby the isthmus (arch between the left subclavian and insertion of the patent ductus arteriosus/ligamentum arteriosum) has a diameter of less than 40% of the diameter of the ascending aorta.\nsynonyms :\n'}


{'id': 'HP_0034228', 'url': 'http://purl.obolibrary.org/obo/HP_0034228', 'lbl': 'Proximal aortic arch hypoplasia', 'desc': 'label: Proximal aortic arch hypoplasia\ndefinition : A type of aortic arch hypoplasia whereby the proximal aortic arch (arch proximal to the origin of the left subclavian artery) has a diameter of less than 60% of the diameter of the ascending aorta.\nsynonyms :\n'}


{'id': 'HP_0034229', 'url': 'http://purl.obolibrary.org/obo/HP_0034229', 'lbl': 'Distal aortic arch hypoplasia', 'desc': 'label: Distal aortic arch hypoplasia\ndefinition : A type of aortic arch hypoplasia whereby the distal aortic arch (arch distal to the ductus arteriosus) has a diameter of less than 60% of the diameter of the ascending aorta.\nsynonyms :\n'}


{'id': 'HP_0034230', 'url': 'http://purl.obolibrary.org/obo/HP_0034230', 'lbl': 'Inferior crossed fused renal ectopia', 'desc': 'label: Inferior crossed fused renal ectopia\ndefinition : A type of cross fused renal ectopia characterized by fusion between the upper pole of the cross-fused ectopic kidney (located more inferiorly relative to the other kidney) and the lower pole of the other orthotopic kidney (located in a more superior position).\nsynonyms :Type A cross fused renal ectopia\n'}


{'id': 'HP_0034231', 'url': 'http://purl.obolibrary.org/obo/HP_0034231', 'lbl': 'Sigmoid kidney', 'desc': 'label: Sigmoid kidney\ndefinition : A type of cross fused renal ectopia where the normal side kidney is present superiorly and the direction of pelvic is medial, the kidney which crosses positioned inferiorly with direction of pelvic toward the lateral side. As kidneys fuse after complete rotation on the vertical axis, both renal pelves lie in correct orientation.\nsynonyms :S-shaped kidney; Type B cross fused renal ectopia\n'}


{'id': 'HP_0034232', 'url': 'http://purl.obolibrary.org/obo/HP_0034232', 'lbl': 'Unilateral lump kidney', 'desc': 'label: Unilateral lump kidney\ndefinition : A type of cross fused renal ectopia where fusion occurs over a wide margin, both renal pelves anteriorly directed and placed more inferiorly.\nsynonyms :Type C cross fused renal ectopia\n'}


{'id': 'HP_0034233', 'url': 'http://purl.obolibrary.org/obo/HP_0034233', 'lbl': 'Disc kidney', 'desc': 'label: Disc kidney\ndefinition : A type of cross fused renal ectopia in which kidneys fuse along their medial borders.\nsynonyms :Type D cross fused renal ectopia\n'}


{'id': 'HP_0034234', 'url': 'http://purl.obolibrary.org/obo/HP_0034234', 'lbl': 'L-shaped kidney', 'desc': 'label: L-shaped kidney\ndefinition : A type of cross fused renal ectopia in which the crossed kidney lies inferiorly and transversely, fused with the lower pole of the normal kidney.\nsynonyms :Tandem kidney; Type E cross fused renal ectopia\n'}


{'id': 'HP_0034235', 'url': 'http://purl.obolibrary.org/obo/HP_0034235', 'lbl': 'Superior crossed-fused renal ectopia', 'desc': 'label: Superior crossed-fused renal ectopia\ndefinition : A type of cross fused renal ectopia in which the ectopic kidney lies superiorly and its lower pole fuses with the upper pole of the normal kidney. The renal pelvis of both kidneys lies anteriorly.\nsynonyms :\n'}


{'id': 'HP_0034236', 'url': 'http://purl.obolibrary.org/obo/HP_0034236', 'lbl': 'Apnea of prematurity', 'desc': 'label: Apnea of prematurity\ndefinition : Recurrent episodes of apnea occurring in infants born less than 37 weeks of gestation, defined specifically as a pause of breathing for more than 15-20 s, or accompanied by oxygen desaturation (SpO2 not more than 80% for at least 4 s) and bradycardia (heart rate less than 2/3 of baseline for at least 4 s), in infants born less than 37 weeks of gestation.\nsynonyms :AOP\n'}


{'id': 'HP_0034237', 'url': 'http://purl.obolibrary.org/obo/HP_0034237', 'lbl': 'Open neural tube defect', 'desc': 'label: Open neural tube defect\ndefinition : A type of neural tube defect that is not covered by skin.\nsynonyms :\n'}


{'id': 'HP_0034238', 'url': 'http://purl.obolibrary.org/obo/HP_0034238', 'lbl': 'Closed neural tube defect', 'desc': 'label: Closed neural tube defect\ndefinition : A type of neural tube defect that is covered by skin.\nsynonyms :\n'}


{'id': 'HP_0034239', 'url': 'http://purl.obolibrary.org/obo/HP_0034239', 'lbl': 'Renal vein thrombosis', 'desc': 'label: Renal vein thrombosis\ndefinition : The presence of a thrombus (blood clot) in the major renal veins or its tributaries, generally leading to passive congestion that develops causes the affected kidney to swell and become engorged, leading to degeneration of nephrons and causing symptoms of flank pain, hematuria, and decreased urine output.\nsynonyms :\n'}


{'id': 'HP_0034240', 'url': 'http://purl.obolibrary.org/obo/HP_0034240', 'lbl': 'Fetal neck mass', 'desc': 'label: Fetal neck mass\ndefinition : An abnormal growth (lump) of tissue in the neck region of a fetus. Masses may be simple cystic,, cystic with a few simple septations (fewer than three septations and less than 3-mm thick), cystic with multiple or thick septations (greater than three septations or septations 3-mm-thick or more), a mass that is than is less than 50% solid, and a mass that is 50% solid or more.\nsynonyms :\n'}


{'id': 'HP_0034241', 'url': 'http://purl.obolibrary.org/obo/HP_0034241', 'lbl': 'Prenatal death', 'desc': 'label: Prenatal death\ndefinition : Death of a fetus in the uterus.\nsynonyms :Death before birth; Intrauterine death\n'}


{'id': 'HP_0034242', 'url': 'http://purl.obolibrary.org/obo/HP_0034242', 'lbl': 'Abnormal fetal genitourinary system morphology', 'desc': 'label: Abnormal fetal genitourinary system morphology\ndefinition : An anomalous structural finding of the fetal genitourinary system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.\nsynonyms :\n'}


{'id': 'HP_0034243', 'url': 'http://purl.obolibrary.org/obo/HP_0034243', 'lbl': 'Abnormal fetal pulmonary morphology', 'desc': 'label: Abnormal fetal pulmonary morphology\ndefinition : An anomalous structural finding of the fetal lungs. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.\nsynonyms :\n'}


{'id': 'HP_0034244', 'url': 'http://purl.obolibrary.org/obo/HP_0034244', 'lbl': 'Gastric pseudomass', 'desc': 'label: Gastric pseudomass\ndefinition : At US examination from the second trimester onward, the fetal stomach appears as a uniformly anechoic, sharply circumscribed round structure in the left upper quadrant. However, debris is commonly visualized in the stomach, forming a pseudomass.\nsynonyms :\n'}


{'id': 'HP_0034245', 'url': 'http://purl.obolibrary.org/obo/HP_0034245', 'lbl': 'Fetal head anomaly', 'desc': 'label: Fetal head anomaly\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034246', 'url': 'http://purl.obolibrary.org/obo/HP_0034246', 'lbl': 'Fetal scalp mass', 'desc': 'label: Fetal scalp mass\ndefinition : An abnormal growth (lump) of tissue that projects from the fetal scalp.\nsynonyms :\n'}


{'id': 'HP_0034247', 'url': 'http://purl.obolibrary.org/obo/HP_0034247', 'lbl': 'Fetal lower urinary tract obstruction', 'desc': 'label: Fetal lower urinary tract obstruction\ndefinition : An obstruction in the ureter leading to bladder outlet obstruction. Special criteria are used for lower urinary tract obstruction (LUTO) in the fetus. Prenatal LUTO has classically been suspected on the basis of three ultrasonographic findings: megacystis, dilated posterior urethra (known as the keyhole sign) and hydronephrosis.\nsynonyms :\n'}


{'id': 'HP_0034248', 'url': 'http://purl.obolibrary.org/obo/HP_0034248', 'lbl': 'Increased fetal lens echogenicity', 'desc': 'label: Increased fetal lens echogenicity\ndefinition : Increased echogenicity (increased brightness in the gray-scale sonography image) of the lens of a fetus.\nsynonyms :\n'}


{'id': 'HP_0034249', 'url': 'http://purl.obolibrary.org/obo/HP_0034249', 'lbl': 'Severe influenza infection', 'desc': 'label: Severe influenza infection\ndefinition : An unusually severe infection by an influenza virus.\nsynonyms :\n'}


{'id': 'HP_0034250', 'url': 'http://purl.obolibrary.org/obo/HP_0034250', 'lbl': 'Fetal nuchal edema', 'desc': 'label: Fetal nuchal edema\ndefinition : Nuchal edema is considered present in a fetus at gestational week 14 or more if in the midsagittal plane of the neck, there is subcutaneous edema that produces a characteristic tremor on ballotment of the fetal head. This constitutes the severe end of the spectrum of increased nuchal fold thickness, which is defined as soft-tissue thickening of 6 mm or more, seen in the suboccipitobregmatic view of the fetal head. Nuchal edema may be confined to the neck or it may be generalized, as part of hydrops fetalis.\nsynonyms :\n'}


{'id': 'HP_0034251', 'url': 'http://purl.obolibrary.org/obo/HP_0034251', 'lbl': 'Abnormal corneal reflex', 'desc': 'label: Abnormal corneal reflex\ndefinition : An anomaly of the corneal reflex that normally induces involuntary blinking of the eyelids following contact of the cornea.\nsynonyms :\n'}


{'id': 'HP_0034252', 'url': 'http://purl.obolibrary.org/obo/HP_0034252', 'lbl': 'Absent corneal reflex', 'desc': 'label: Absent corneal reflex\ndefinition : Absence of the corneal blinking reflex, which normally induces involuntary blinking of the eyelids following contact of the cornea. The corneal blink reflex is caused by a loop between the trigeminal sensory nerves and the facial motor (VII) nerve innervation of the orbicularis oculi muscles.\nsynonyms :\n'}


{'id': 'HP_0034253', 'url': 'http://purl.obolibrary.org/obo/HP_0034253', 'lbl': 'Eosinophil nuclear hypersegmentation', 'desc': 'label: Eosinophil nuclear hypersegmentation\ndefinition : An excessive division of the lobes of the nucleus of eosinophils. Eosinophils with more than two nuclear lobes are commonly regarded as hypersegmented, because seventy to ninety percent of peripheral blood eosinophils have two nuclear lobes.\nsynonyms :\n'}


{'id': 'HP_0034254', 'url': 'http://purl.obolibrary.org/obo/HP_0034254', 'lbl': 'Face of the giant panda sign', 'desc': 'label: Face of the giant panda sign\ndefinition : The face of the giant panda sign on T2-weighted MRI is characterized by preservation of normal signal intensity in the red nuclei and lateral portion of the pars reticulata of the substantia nigra, high signal in the tegmentum, and hypointensity of the superior colliculus. The findings are said to resemble the face of a giant panda.\nsynonyms :Midbrain panda sign\n'}


{'id': 'HP_0034255', 'url': 'http://purl.obolibrary.org/obo/HP_0034255', 'lbl': 'Colovesical fistula', 'desc': 'label: Colovesical fistula\ndefinition : An aberrant, pathological communication between the colon and the bladder.\nsynonyms :Colovesicular fistula; Vesicocolic fistula\n'}


{'id': 'HP_0034256', 'url': 'http://purl.obolibrary.org/obo/HP_0034256', 'lbl': 'Absent dermoepidermal hemidesmosomes', 'desc': 'label: Absent dermoepidermal hemidesmosomes\ndefinition : Lack of demonstrable hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin.\nsynonyms :\n'}


{'id': 'HP_0034257', 'url': 'http://purl.obolibrary.org/obo/HP_0034257', 'lbl': 'C4 nephritic factor positivity', 'desc': 'label: C4 nephritic factor positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the blood circulation that recognize C4b2a, the C3 convertase of the classical pathway of complement.\nsynonyms :\n'}


{'id': 'HP_0034258', 'url': 'http://purl.obolibrary.org/obo/HP_0034258', 'lbl': 'Aplasia/Hypoplasia of the midbrain', 'desc': 'label: Aplasia/Hypoplasia of the midbrain\ndefinition : Absence or underdevelopment of the midbrain (mesencephalon).\nsynonyms :Aplasia/Hypoplasia of the mesencephalon\n'}


{'id': 'HP_0034259', 'url': 'http://purl.obolibrary.org/obo/HP_0034259', 'lbl': 'Hypoplasia of the midbrain', 'desc': 'label: Hypoplasia of the midbrain\ndefinition : A developmental defect characterized by underdevelopment of the mesencephalon.\nsynonyms :Hypoplasia of the mesencephalon; Hypoplastic mesencephalon\n'}


{'id': 'HP_0034260', 'url': 'http://purl.obolibrary.org/obo/HP_0034260', 'lbl': 'Aplastic zygomatic arch', 'desc': 'label: Aplastic zygomatic arch\ndefinition : Developmental defect characterized by the absence of the zygomatic arch.\nsynonyms :\n'}


{'id': 'HP_0034261', 'url': 'http://purl.obolibrary.org/obo/HP_0034261', 'lbl': 'Aplasia/Hypoplasia of facial bones', 'desc': 'label: Aplasia/Hypoplasia of facial bones\ndefinition : A developmental defect characterized by absence or underdevelopment of one or more facial bone.\nsynonyms :\n'}


{'id': 'HP_0034262', 'url': 'http://purl.obolibrary.org/obo/HP_0034262', 'lbl': 'Absent lanugo', 'desc': 'label: Absent lanugo\ndefinition : Lack of development of lanugo, the fine, soft, unpigmented hair on the body of a fetus or newborn baby.\nsynonyms :\n'}


{'id': 'HP_0034263', 'url': 'http://purl.obolibrary.org/obo/HP_0034263', 'lbl': 'Abnormal vaginal bleeding', 'desc': 'label: Abnormal vaginal bleeding\ndefinition : Abnormal vaginal bleeding occurs between menstrual periods, after sex, or after menopause. Menstrual periods that are heavier or last longer than usual or last more than seven days also are considered abnormal.\nsynonyms :\n'}


{'id': 'HP_0034264', 'url': 'http://purl.obolibrary.org/obo/HP_0034264', 'lbl': 'Postcoital vaginal bleeding', 'desc': "label: Postcoital vaginal bleeding\ndefinition : Postcoital bleeding (PCB) consists of spotting or bleeding after sexual intercourse that is not related to a person's menstrual cycle.\nsynonyms :Bleeding after sex\n"}


{'id': 'HP_0034265', 'url': 'http://purl.obolibrary.org/obo/HP_0034265', 'lbl': 'Mastalgia', 'desc': 'label: Mastalgia\ndefinition : Pain in the breast.\nsynonyms :Breast pain; Painful breast\n'}


{'id': 'HP_0034266', 'url': 'http://purl.obolibrary.org/obo/HP_0034266', 'lbl': 'Vaginal bleeding during sex', 'desc': 'label: Vaginal bleeding during sex\ndefinition : Bleeding during sex.\nsynonyms :\n'}


{'id': 'HP_0034267', 'url': 'http://purl.obolibrary.org/obo/HP_0034267', 'lbl': 'Pelvic pain', 'desc': 'label: Pelvic pain\ndefinition : Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones.\nsynonyms :Pain in the pelvis\n'}


{'id': 'HP_0034268', 'url': 'http://purl.obolibrary.org/obo/HP_0034268', 'lbl': 'Abnormal vaginal physiology', 'desc': 'label: Abnormal vaginal physiology\ndefinition : Any anomaly of vagina function.\nsynonyms :\n'}


{'id': 'HP_0034269', 'url': 'http://purl.obolibrary.org/obo/HP_0034269', 'lbl': 'Abnormal vaginal discharge', 'desc': 'label: Abnormal vaginal discharge\ndefinition : Anomalous amount, odor, or consistency of the fluid or mucus that comes from the vagina\nsynonyms :\n'}


{'id': 'HP_0034270', 'url': 'http://purl.obolibrary.org/obo/HP_0034270', 'lbl': 'Serrated incisors', 'desc': 'label: Serrated incisors\ndefinition : Incisor teeth with irregular edges said to resemble a saw.\nsynonyms :Jagged incisors\n'}


{'id': 'HP_0034271', 'url': 'http://purl.obolibrary.org/obo/HP_0034271', 'lbl': 'Copper beaten skull', 'desc': 'label: Copper beaten skull\ndefinition : Diffuse prominent gyral impressions on the inner table of skull vault said to resemble beaten copper.\nsynonyms :\n'}


{'id': 'HP_0034272', 'url': 'http://purl.obolibrary.org/obo/HP_0034272', 'lbl': 'Perifoveal hypoautofluorescence', 'desc': 'label: Perifoveal hypoautofluorescence\ndefinition : Decreased amount of autofluorescence (emission of fluorescent light from ocular structures in the absence of sodium fluorescein) in the retina in the region surrounding the fovea.\nsynonyms :\n'}


{'id': 'HP_0034273', 'url': 'http://purl.obolibrary.org/obo/HP_0034273', 'lbl': 'Premature sagging cheeks', 'desc': 'label: Premature sagging cheeks\ndefinition : Drooping or sinking of tissues of the cheeks more than would be expected at a given age. Sagging can occur due to a relative excess of skin and/or lack of elastic recoil as well as fat accumulation.\nsynonyms :Premature facial sagging\n'}


{'id': 'HP_0034274', 'url': 'http://purl.obolibrary.org/obo/HP_0034274', 'lbl': 'Gastrointestinal ulcer', 'desc': 'label: Gastrointestinal ulcer\ndefinition : A deep defect in the esophageal, gastric, duodenal or intestinal wall involving the entire mucosal thickness and penetrating through the muscularis mucosae.\nsynonyms :\n'}


{'id': 'HP_0034275', 'url': 'http://purl.obolibrary.org/obo/HP_0034275', 'lbl': 'Verrucous epidermal nevus', 'desc': 'label: Verrucous epidermal nevus\ndefinition : A type of epidermal nevus (which represent Blaschkoid hamartomas of the skin that result from mosaic post-zygotic mutations) that appears as skin-colored-to-brown, sharply demarcated, papillomatous papules that coalesce into plaques. The majority of these nevi are either present at birth or occur within the first year of life.\nsynonyms :\n'}


{'id': 'HP_0034276', 'url': 'http://purl.obolibrary.org/obo/HP_0034276', 'lbl': 'Elevated circulating thymidine concentration', 'desc': 'label: Elevated circulating thymidine concentration\ndefinition : Concentration of thymidine in the blood circulation above the normal range.\nsynonyms :Increased serum thymidine\n'}


{'id': 'HP_0034277', 'url': 'http://purl.obolibrary.org/obo/HP_0034277', 'lbl': 'Elevated circulating deoxyuridine concentration', 'desc': 'label: Elevated circulating deoxyuridine concentration\ndefinition : Concentration of 2-deoxyuridine in the blood circulation is above the normal range.\nsynonyms :\n'}


{'id': 'HP_0034278', 'url': 'http://purl.obolibrary.org/obo/HP_0034278', 'lbl': 'Multinucleated erythroblast', 'desc': 'label: Multinucleated erythroblast\ndefinition : Erythroblasts with multiple nuclei. Erythroblasts are nucleated precrusor cells of erythrocytes that are localized to the bone marrow. Normally, erythroblasts have a single nucleus. The abnormal finding of erythrocytes with two or more nuclei may be related to defects in cytokinesis.\nsynonyms :Bone marrow: multinucleated erythroblasts; Multinucleate erythroblast\n'}


{'id': 'HP_0034279', 'url': 'http://purl.obolibrary.org/obo/HP_0034279', 'lbl': '2,8-dihydroxyadenine crystalluria', 'desc': 'label: 2,8-dihydroxyadenine crystalluria\ndefinition : The presence of 2,8-dihydroxyadenine crystals in the urine. The crystals appear as round, yellow-brown crystals.\nsynonyms :2,8-dihydroxyadenine urinary crystals\n'}


{'id': 'HP_0034280', 'url': 'http://purl.obolibrary.org/obo/HP_0034280', 'lbl': 'Target cells', 'desc': 'label: Target cells\ndefinition : Target cells (codocytes) have a centrally located disk of hemoglobin surrounded by an area of pallor with an outer rim of hemoglobin adjacent to the cell membrane giving the cell the appearance of a target.\nsynonyms :Codocytes\n'}


{'id': 'HP_0034281', 'url': 'http://purl.obolibrary.org/obo/HP_0034281', 'lbl': 'Phalangeal cone-shaped epiphyses', 'desc': 'label: Phalangeal cone-shaped epiphyses\ndefinition : Cone-shaped epiphyses of the phalanges of the hands or feet. Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery.\nsynonyms :Cone-shaped epiphyses of phalanges; Cone-shaped phalangeal epiphyses\n'}


{'id': 'HP_0034282', 'url': 'http://purl.obolibrary.org/obo/HP_0034282', 'lbl': 'Subcutaneous ossification', 'desc': 'label: Subcutaneous ossification\ndefinition : Formation of abnormal, extraskeletal bony tissue in the soft tissue beneath the skin. Subcutaneous ossifications may be observed by radiography or by palpation.\nsynonyms :\n'}


{'id': 'HP_0034283', 'url': 'http://purl.obolibrary.org/obo/HP_0034283', 'lbl': 'Increased fecal protoporphyrin concentration', 'desc': 'label: Increased fecal protoporphyrin concentration\ndefinition : Abnormally high concentration of protoporphyrin (derivative of porphyrin with propionic acid groups) in feces.\nsynonyms :\n'}


{'id': 'HP_0034284', 'url': 'http://purl.obolibrary.org/obo/HP_0034284', 'lbl': 'Recurrent gingivitis', 'desc': 'label: Recurrent gingivitis\ndefinition : Repeated occurrences of inflammatory condition of the gums (gingival tissue), most commonly caused by bacterial infection.\nsynonyms :\n'}


{'id': 'HP_0034285', 'url': 'http://purl.obolibrary.org/obo/HP_0034285', 'lbl': 'Enteroviral encephalitis', 'desc': 'label: Enteroviral encephalitis\ndefinition : Inflamation of the brain related to infection by an enterovirus.\nsynonyms :\n'}


{'id': 'HP_0034286', 'url': 'http://purl.obolibrary.org/obo/HP_0034286', 'lbl': 'Pneumocystis carinii pneumonia', 'desc': 'label: Pneumocystis carinii pneumonia\ndefinition : Pneumocystis carinii pneumonia is an opportunistic infection that occurs in immunosuppressed populations.\nsynonyms :\n'}


{'id': 'HP_0034287', 'url': 'http://purl.obolibrary.org/obo/HP_0034287', 'lbl': 'Afibrinogenemia', 'desc': 'label: Afibrinogenemia\ndefinition : Lack of detectable fibrinogen in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034288', 'url': 'http://purl.obolibrary.org/obo/HP_0034288', 'lbl': 'Elevated circulating reverse T3 concentration', 'desc': "label: Elevated circulating reverse T3 concentration\ndefinition : Abnormally increased concentration of reverse T3 (3,3',5'-triiodothyronine or rT3) in the blood circulation.\nsynonyms :Elevated circulating reverse triiodothyronine concentration; Elevated rT3\n"}


{'id': 'HP_0034289', 'url': 'http://purl.obolibrary.org/obo/HP_0034289', 'lbl': 'Elevated circulating rT3/T3 ratio', 'desc': 'label: Elevated circulating rT3/T3 ratio\ndefinition : An abnormally increased ratio of the concentrations of reverse T3 to T3 in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034290', 'url': 'http://purl.obolibrary.org/obo/HP_0034290', 'lbl': 'Elevated circulating tiglylglycine concentration', 'desc': 'label: Elevated circulating tiglylglycine concentration\ndefinition : An increased concentration of tiglylglycine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034291', 'url': 'http://purl.obolibrary.org/obo/HP_0034291', 'lbl': 'Elevated circulating creatine concentration', 'desc': 'label: Elevated circulating creatine concentration\ndefinition : An elevation above the normal range of creatine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034292', 'url': 'http://purl.obolibrary.org/obo/HP_0034292', 'lbl': 'Reduced circulating creatine concentration', 'desc': 'label: Reduced circulating creatine concentration\ndefinition : An reduction below the normal range of creatine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034293', 'url': 'http://purl.obolibrary.org/obo/HP_0034293', 'lbl': 'Temporal lobe calcification', 'desc': 'label: Temporal lobe calcification\ndefinition : The presence of calcium deposition within the temporal lobe of the brain.\nsynonyms :\n'}


{'id': 'HP_0034294', 'url': 'http://purl.obolibrary.org/obo/HP_0034294', 'lbl': 'Ductal bile plugs', 'desc': 'label: Ductal bile plugs\ndefinition : Bile thrombi that form an obstruction (plug) in a dilated bile duct.\nsynonyms :\n'}


{'id': 'HP_0034295', 'url': 'http://purl.obolibrary.org/obo/HP_0034295', 'lbl': 'Reduced cerebral white matter volume', 'desc': 'label: Reduced cerebral white matter volume\ndefinition : An abnormally low volume of the white matter of the brain.\nsynonyms :White matter loss\n'}


{'id': 'HP_0034296', 'url': 'http://purl.obolibrary.org/obo/HP_0034296', 'lbl': 'Elevated urine 3,5,6-trichloro-2-pyridinol level', 'desc': 'label: Elevated urine 3,5,6-trichloro-2-pyridinol level\ndefinition : Detection of 3,5,6-trichloro-2-pyridinol in the urine.\nsynonyms :\n'}


{'id': 'HP_0034297', 'url': 'http://purl.obolibrary.org/obo/HP_0034297', 'lbl': 'Elevated circulating tetracosanoic acid concentration', 'desc': 'label: Elevated circulating tetracosanoic acid concentration\ndefinition : Elevated concentration of tetracosanoic acid (a C24 straight-chain saturated fatty acid) in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034298', 'url': 'http://purl.obolibrary.org/obo/HP_0034298', 'lbl': 'Elevated circulating hexacosanoic acid concentration', 'desc': 'label: Elevated circulating hexacosanoic acid concentration\ndefinition : Elevated concentration of hexacosanoic acid (a C26 straight-chain saturated fatty acid) in the blood circulation.\nsynonyms :Elevated circulating cerotic acid concentration\n'}


{'id': 'HP_0034299', 'url': 'http://purl.obolibrary.org/obo/HP_0034299', 'lbl': 'Sertoli cell-only phenotype', 'desc': 'label: Sertoli cell-only phenotype\ndefinition : A histological phenotype observed on testicular biopsy in which only Sertoli cells line the seminiferous tubules of the testis.\nsynonyms :\n'}


{'id': 'HP_0034300', 'url': 'http://purl.obolibrary.org/obo/HP_0034300', 'lbl': 'Decreased acid sphingomyelinase activity', 'desc': 'label: Decreased acid sphingomyelinase activity\ndefinition : Reduced activity of the enzyme acid sphingomyelinase activity in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034301', 'url': 'http://purl.obolibrary.org/obo/HP_0034301', 'lbl': 'Congenital pouch colon', 'desc': 'label: Congenital pouch colon\ndefinition : A malformation of the colon in which a pouch-like dilatation of a varying degree of shortened colon is associated with an anorectal malformation. The pouch usually terminates in a fistulous communication with the genitourinary tract.\nsynonyms :\n'}


{'id': 'HP_0034302', 'url': 'http://purl.obolibrary.org/obo/HP_0034302', 'lbl': 'Megalopapilla', 'desc': 'label: Megalopapilla\ndefinition : A congenitally anomalous enlarged optic disk (surface area greater than 2.50 square millimeters). It is considered to be a normal variant without physiological defects.\nsynonyms :\n'}


{'id': 'HP_0034303', 'url': 'http://purl.obolibrary.org/obo/HP_0034303', 'lbl': 'Notched T wave', 'desc': 'label: Notched T wave\ndefinition : A bifid T-wave with a notch duration between the 2 peaks at leasy 0.04 sec and an amplitude at least 0.05 mV.\nsynonyms :Notched T-wave\n'}


{'id': 'HP_0034304', 'url': 'http://purl.obolibrary.org/obo/HP_0034304', 'lbl': 'Epsilon wave', 'desc': 'label: Epsilon wave\ndefinition : An electric signal of depolarization observed between the end of the QRS complex and the beginning of the T wave.\nsynonyms :\n'}


{'id': 'HP_0034305', 'url': 'http://purl.obolibrary.org/obo/HP_0034305', 'lbl': '2:1 atrioventricular block', 'desc': 'label: 2:1 atrioventricular block\ndefinition : A type of second-degree atrioventricular block in which every other P wave is not conducted through the AV node such that only every other P wave is followed by a QRS complex.\nsynonyms :2:1 AV block\n'}


{'id': 'HP_0034306', 'url': 'http://purl.obolibrary.org/obo/HP_0034306', 'lbl': 'Ventricular bigeminy', 'desc': 'label: Ventricular bigeminy\ndefinition : An electrocardiographic finding of a normal QRS followed by a premature ventricular contraction; a rhythmic pairing of normal and atypical beats originating in the ventricles in a 1-1 ratio such that an ectopic ventricular beat follows each regular heartbeat.\nsynonyms :\n'}


{'id': 'HP_0034307', 'url': 'http://purl.obolibrary.org/obo/HP_0034307', 'lbl': 'Elevated left ventricular end-diastolic diameter', 'desc': 'label: Elevated left ventricular end-diastolic diameter\ndefinition : The LV end-diastolic internal diameter was measured from two-dimensional (2D) images in the parasternal long-axis view, timed with mitral valve closure at the level of the mitral valve chordae.\nsynonyms :\n'}


{'id': 'HP_0034308', 'url': 'http://purl.obolibrary.org/obo/HP_0034308', 'lbl': 'Prolonged P wave', 'desc': 'label: Prolonged P wave\ndefinition : Abnormal increased in the duration of the P wave, which is a marker of delayed inter-atrial conduction.\nsynonyms :\n'}


{'id': 'HP_0034309', 'url': 'http://purl.obolibrary.org/obo/HP_0034309', 'lbl': 'Multiflagellar spermatozoa', 'desc': 'label: Multiflagellar spermatozoa\ndefinition : Spermatozoa with multiple flagella attached to the sperm head.\nsynonyms :Multi-tailed spermatozoa\n'}


{'id': 'HP_0034310', 'url': 'http://purl.obolibrary.org/obo/HP_0034310', 'lbl': 'Post-vaccination yellow fever', 'desc': 'label: Post-vaccination yellow fever\ndefinition : Infection with the yellow fever virus of the live-attenuated vaccine.\nsynonyms :Postvaccination yellow fever\n'}


{'id': 'HP_0034311', 'url': 'http://purl.obolibrary.org/obo/HP_0034311', 'lbl': 'Hypoplastic optic chiasm', 'desc': 'label: Hypoplastic optic chiasm\ndefinition : Developmental defect characterized by undergrowth of the optic chiasm.\nsynonyms :Optic chiasm hypoplasia\n'}


{'id': 'HP_0034312', 'url': 'http://purl.obolibrary.org/obo/HP_0034312', 'lbl': 'Nocturnal hypoxemia', 'desc': 'label: Nocturnal hypoxemia\ndefinition : Abnormally reduced oxyhemoglobin saturation during sleep (nocturnal). Different thresholds are used in the literature, including more than 10 percent of total sleep time below a SpO2 of 90 percent.\nsynonyms :Sleep hypoxemia; Sleep-related hypoxemia\n'}


{'id': 'HP_0034313', 'url': 'http://purl.obolibrary.org/obo/HP_0034313', 'lbl': 'Hyperdynamic left ventricular ejection fraction', 'desc': 'label: Hyperdynamic left ventricular ejection fraction\ndefinition : An abnoramlly increased ejection fraction of the left ventricle, usually defined as a left ventricular ejection fraction greater than 70 percent.\nsynonyms :\n'}


{'id': 'HP_0034314', 'url': 'http://purl.obolibrary.org/obo/HP_0034314', 'lbl': 'Abnormal left ventricular ejection fraction', 'desc': 'label: Abnormal left ventricular ejection fraction\ndefinition : Any abnormality of the left ventricular ejection fraction (LVEF), which is the fraction of chamber volume ejected in systole (stroke volume) in relation to the volume of the blood in the ventricle at the end of diastole (end-diastolic volume). Stroke volume (SV) is calculated as the difference between end-diastolic volume (EDV) and end-systolic volume (ESV). LVEF is calculated as [SV/EDV] in percent.\nsynonyms :\n'}


{'id': 'HP_0034315', 'url': 'http://purl.obolibrary.org/obo/HP_0034315', 'lbl': 'Chronic cough', 'desc': 'label: Chronic cough\ndefinition : A persistent cough, defined as a cough lasting longer than eight weeks in adults or longer than four weeks in children.\nsynonyms :\n'}


{'id': 'HP_0034316', 'url': 'http://purl.obolibrary.org/obo/HP_0034316', 'lbl': 'Thinning of the substantia nigra pars compacta', 'desc': 'label: Thinning of the substantia nigra pars compacta\ndefinition : Reduced volume of pars compacta of the substantia nigra.\nsynonyms :\n'}


{'id': 'HP_0034317', 'url': 'http://purl.obolibrary.org/obo/HP_0034317', 'lbl': 'Unusual viral infection', 'desc': 'label: Unusual viral infection\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034318', 'url': 'http://purl.obolibrary.org/obo/HP_0034318', 'lbl': 'Unusual virus reactivation', 'desc': 'label: Unusual virus reactivation\ndefinition : Reactivation is the mechanism whereby a latent virus that has infected a host cell switches to a lytic stage, undergoing productive viral replication and allowing the virus to spread. This term refers to reactivation regarded as unusual because of frequency, intensity, location, or nature of the virus, in the sense that the reactivation would not be observed in an immunocompetent host.\nsynonyms :\n'}


{'id': 'HP_0034319', 'url': 'http://purl.obolibrary.org/obo/HP_0034319', 'lbl': 'CNS vasculitis with reactivation of varicella-zoster virus', 'desc': 'label: CNS vasculitis with reactivation of varicella-zoster virus\ndefinition : A vasculopathy in the central nervous system (CNS) following reactivation of varicella-zoster virus due to a productive viral infection of both large and small cerebral arteries.\nsynonyms :\n'}


{'id': 'HP_0034320', 'url': 'http://purl.obolibrary.org/obo/HP_0034320', 'lbl': 'Muscle fiber intracytoplasmic reducing inclusion bodies', 'desc': 'label: Muscle fiber intracytoplasmic reducing inclusion bodies\ndefinition : Intracytoplasmic inclusions in myofibers that reduce nitro-blue tetrazolium (NBT) and thus stain strongly with the menadione-NBT stain.\nsynonyms :Intracytoplasmic myofiber reducing inclusion bodies\n'}


{'id': 'HP_0034321', 'url': 'http://purl.obolibrary.org/obo/HP_0034321', 'lbl': 'Elevated circulating guanidinoacetic acid concentration', 'desc': 'label: Elevated circulating guanidinoacetic acid concentration\ndefinition : An increased concentration of guanidinoacetic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034322', 'url': 'http://purl.obolibrary.org/obo/HP_0034322', 'lbl': 'Reduced galactocerebrosidase activity', 'desc': 'label: Reduced galactocerebrosidase activity\ndefinition : Diminished enzyme activity of galactocerebrosidase.\nsynonyms :\n'}


{'id': 'HP_0034323', 'url': 'http://purl.obolibrary.org/obo/HP_0034323', 'lbl': 'Reduced circulating growth hormone concentration', 'desc': 'label: Reduced circulating growth hormone concentration\ndefinition : Concentration of growth hormone in the blood circulation below normal limits.\nsynonyms :\n'}


{'id': 'HP_0034324', 'url': 'http://purl.obolibrary.org/obo/HP_0034324', 'lbl': 'Brachiocephalic artery aneurysm', 'desc': 'label: Brachiocephalic artery aneurysm\ndefinition : An abnormal widening (dilatation) of the brachiocephalic artery\nsynonyms :Dilatated brachiocephalic artery; Innominate artery aneurysm\n'}


{'id': 'HP_0034325', 'url': 'http://purl.obolibrary.org/obo/HP_0034325', 'lbl': 'Common carotid artery aneurysm', 'desc': 'label: Common carotid artery aneurysm\ndefinition : An abnormal widening (dilatation) of the common carotid artery.\nsynonyms :\n'}


{'id': 'HP_0034326', 'url': 'http://purl.obolibrary.org/obo/HP_0034326', 'lbl': 'Adenomyosis', 'desc': 'label: Adenomyosis\ndefinition : Inappropriate (ectopic) endometrial tissue proliferation within the uterine myometrium, often presenting clinically with painful menses and heavy menstrual bleeding.\nsynonyms :\n'}


{'id': 'HP_0034327', 'url': 'http://purl.obolibrary.org/obo/HP_0034327', 'lbl': 'Posterior corneal stroma punctiform multicolored opacities', 'desc': 'label: Posterior corneal stroma punctiform multicolored opacities\ndefinition : Thin, punctiform elements of various colors in the posterior stroma of the cornea, immediately anterior to Descemet membrane. The elements are visible to direct and indirect illumination.\nsynonyms :Punctiform multicolored opacities in the posterior corneal stroma\n'}


{'id': 'HP_0034328', 'url': 'http://purl.obolibrary.org/obo/HP_0034328', 'lbl': 'Fibro-obliterative bile-duct lesion', 'desc': 'label: Fibro-obliterative bile-duct lesion\ndefinition : A condition in which the lumen of a bile duct has been filled by fibrous scar material, in effect replacing the bile duct with a fibrous scar.\nsynonyms :Fibro-obliterative bile-duct scarring; Fibro-obliterative loss of bile ducts\n'}


{'id': 'HP_0034329', 'url': 'http://purl.obolibrary.org/obo/HP_0034329', 'lbl': 'Dysplastic megalencephaly', 'desc': 'label: Dysplastic megalencephaly\ndefinition : A congenital brain malformation characterized by marked overgrowth and dysplasia affecting one or both cerebral hemispheres, and, in some cases, subcortical brain regions as well. The presence of dysplasia in dysplastic megalencephaly distinguishes it from other forms of generalized megalencephaly.\nsynonyms :Bilateral hemimegalencephaly\n'}


{'id': 'HP_0034330', 'url': 'http://purl.obolibrary.org/obo/HP_0034330', 'lbl': 'Regional right ventricular hypokinesis', 'desc': 'label: Regional right ventricular hypokinesis\ndefinition : Decreased range of right ventricular motion in a portion of the right ventricle of the heart.\nsynonyms :\n'}


{'id': 'HP_0034331', 'url': 'http://purl.obolibrary.org/obo/HP_0034331', 'lbl': 'McConnell sign', 'desc': 'label: McConnell sign\ndefinition : Severe hypokinesia of the mid-free wall of the right ventricle of the heart with a normal contraction of the apical segment of the right ventricle.\nsynonyms :\n'}


{'id': 'HP_0034332', 'url': 'http://purl.obolibrary.org/obo/HP_0034332', 'lbl': 'Cognitive regression', 'desc': 'label: Cognitive regression\ndefinition : Loss of cognitive developmental skills, as manifested by loss of developmental cognitive milestones.\nsynonyms :\n'}


{'id': 'HP_0034333', 'url': 'http://purl.obolibrary.org/obo/HP_0034333', 'lbl': 'Increased circulating hypoxanthine concentration', 'desc': 'label: Increased circulating hypoxanthine concentration\ndefinition : Elevated concentration of hypoxanthine in the blood circulation.\nsynonyms :Hypoxanthine high in blood\n'}


{'id': 'HP_0034334', 'url': 'http://purl.obolibrary.org/obo/HP_0034334', 'lbl': 'allelic_requirement', 'desc': 'label: allelic_requirement\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034335', 'url': 'http://purl.obolibrary.org/obo/HP_0034335', 'lbl': 'Inheritance modifier', 'desc': 'label: Inheritance modifier\ndefinition : The terms in this hierarchy can be used to specificy the context in which inheritance of a disease is typically observed.\nsynonyms :\n'}


{'id': 'HP_0034336', 'url': 'http://purl.obolibrary.org/obo/HP_0034336', 'lbl': 'Splenic infarction', 'desc': 'label: Splenic infarction\ndefinition : Ischemia and necrosis of part or all of the spleen resulting from compromise of blood supply resulting from arterial or venous occlusion.\nsynonyms :Spleen infarct; Spleen infarction; Splenic infarct\n'}


{'id': 'HP_0034337', 'url': 'http://purl.obolibrary.org/obo/HP_0034337', 'lbl': 'Claw hand deformity', 'desc': 'label: Claw hand deformity\ndefinition : An abnormality of the hand characterized by metacarpophalangeal (MCP) hyperextension and proximal interphalangeal (PIP) and distal interphalangeal (DIP) flexion. The position of the affected hand is said to resemble a claw.\nsynonyms :\n'}


{'id': 'HP_0034338', 'url': 'http://purl.obolibrary.org/obo/HP_0034338', 'lbl': 'Imprinted', 'desc': 'label: Imprinted\ndefinition : Requires that the abnormal allele be paternal or maternal in origin, depending on the disease-gene relationship. Imprinting refers to a normal developmental process in which either the paternal or maternal allele is inactivated, depending on the specific locus, thus leading to expression from only one copy of the gene. Disease typically manifests when a deleterious variant is inherited from a parent whose copy of the gene would normally be expressed, but not when a deleterious variant is inherited from a parent whose copy of the gene would normally be inactivated.\nsynonyms :\n'}


{'id': 'HP_0034339', 'url': 'http://purl.obolibrary.org/obo/HP_0034339', 'lbl': 'Pseudoautosomal inheritance', 'desc': 'label: Pseudoautosomal inheritance\ndefinition : A pattern of inheritance observed for alleles in the X-Y identical regions is referred to as pseudoautosomal inheritance, because it resembles the pattern seen for alleles located on autosomes.\nsynonyms :Pseudoautosomal region inheritance\n'}


{'id': 'HP_0034340', 'url': 'http://purl.obolibrary.org/obo/HP_0034340', 'lbl': 'Pseudoautosomal dominant inheritance', 'desc': 'label: Pseudoautosomal dominant inheritance\ndefinition : A type of pseudoautosomal inheritance that is dominant and in which heterozygous males and females both manifest a disease phenotype.\nsynonyms :monoallelic_PAR\n'}


{'id': 'HP_0034341', 'url': 'http://purl.obolibrary.org/obo/HP_0034341', 'lbl': 'Pseudoautosomal recessive inheritance', 'desc': 'label: Pseudoautosomal recessive inheritance\ndefinition : A type of pseudoautosomal inheritance that is recessive and in which biallelic males and females both manifest a disease phenotype.\nsynonyms :biallelic_PAR\n'}


{'id': 'HP_0034342', 'url': 'http://purl.obolibrary.org/obo/HP_0034342', 'lbl': 'Trapezius muscle aplasia', 'desc': 'label: Trapezius muscle aplasia\ndefinition : A developmental defect characterized by lack of formation of the trapezius muscle, which is broad superficial muscle that extends from the posterior neck to the posterior part of the trunk (thorax).\nsynonyms :\n'}


{'id': 'HP_0034343', 'url': 'http://purl.obolibrary.org/obo/HP_0034343', 'lbl': 'Requires heterozygosity', 'desc': 'label: Requires heterozygosity\ndefinition : A rarely encountered phenomenon in which condition is most severe in the heterozygous state. Such disorders are rare and currently all are X-linked. Most X-linked recessive conditions manifest if hemizygous in males, or biallelic in females, though may have a mild phenotype in the heterozygous state in females.\nsynonyms :\n'}


{'id': 'HP_0034344', 'url': 'http://purl.obolibrary.org/obo/HP_0034344', 'lbl': 'Female-limited expression', 'desc': 'label: Female-limited expression\ndefinition : Used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in the female sex.\nsynonyms :\n'}


{'id': 'HP_0034345', 'url': 'http://purl.obolibrary.org/obo/HP_0034345', 'lbl': 'Mendelian inheritance', 'desc': 'label: Mendelian inheritance\ndefinition : A mode of inheritance of diseases whose pathophysiology can be traced back to deleterious variants in a single gene. The inheritance patterns of these single-gene (monogenic) diseases are often referred to as Mendelian in honor of Gregor Mendel.\nsynonyms :\n'}


{'id': 'HP_0034346', 'url': 'http://purl.obolibrary.org/obo/HP_0034346', 'lbl': 'Nesidioblastosis', 'desc': 'label: Nesidioblastosis\ndefinition : An abnormality of pancreatic beta cells characterized by a proliferation of abnormal beta cells throughout the entire pancreas, with enlarged islet size and number (hypertrophic islets), increased periductular islets, enlarged beta-cell nuclei and abundant clear cytoplasm. Occasionally beta cells with pleomorphic nuclei, ductuloinsular complexes, and neoformation of islets from ducts are observed.\nsynonyms :\n'}


{'id': 'HP_0034347', 'url': 'http://purl.obolibrary.org/obo/HP_0034347', 'lbl': 'Greater auricular nerve thickening', 'desc': 'label: Greater auricular nerve thickening\ndefinition : Increase in thickness of the great auricular nerve, a cutaneous nerve of the head. It originates from the cervical plexus, with branches of spinal nerves C2 and C3. Thickening may lead to the nerve being palpable or even visible in this region.\nsynonyms :Palpable great auricular nerve\n'}


{'id': 'HP_0034348', 'url': 'http://purl.obolibrary.org/obo/HP_0034348', 'lbl': 'Subpulmonary stenosis', 'desc': 'label: Subpulmonary stenosis\ndefinition : A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately below the pulmonary valve.\nsynonyms :Infundibular pulmonary stenosis; Infundibular pulmonic stenosis; Subvalvar pulmonary stenosis; Subvalvar pulmonic stenosis; Subvalvular pulmonary stenosis; Subvalvular pulmonic stenosis\n'}


{'id': 'HP_0034349', 'url': 'http://purl.obolibrary.org/obo/HP_0034349', 'lbl': 'Supravalvar pulmonary stenosis', 'desc': 'label: Supravalvar pulmonary stenosis\ndefinition : A cardiovascular malformation associated with narrowing at the level of the pulmonary sinotubular junction above the pulmonic valve.\nsynonyms :Supravalvar pulmonnic stenosis; Supravalvular pulmonary stenosis; Supravalvular pulmonic stenosis\n'}


{'id': 'HP_0034350', 'url': 'http://purl.obolibrary.org/obo/HP_0034350', 'lbl': 'Valvular pulmonary stenosis', 'desc': 'label: Valvular pulmonary stenosis\ndefinition : A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately at the level of the pulmonary valve.\nsynonyms :\n'}


{'id': 'HP_0034351', 'url': 'http://purl.obolibrary.org/obo/HP_0034351', 'lbl': 'Neuromyotonia', 'desc': 'label: Neuromyotonia\ndefinition : Peripheral nerve hyperexcitability manifesting as spontaneous discharges originating from motor axons or their terminals, lead to overactivity of muscles, typically manifesting as twitches, cramps and stiffness.\nsynonyms :Peripheral nerve hyperexcitability\n'}


{'id': 'HP_0034352', 'url': 'http://purl.obolibrary.org/obo/HP_0034352', 'lbl': 'Bile duct polyp', 'desc': 'label: Bile duct polyp\ndefinition : An elevated growth from the the mucosa of the bile duct.\nsynonyms :\n'}


{'id': 'HP_0034353', 'url': 'http://purl.obolibrary.org/obo/HP_0034353', 'lbl': 'Appendicular spasticity', 'desc': 'label: Appendicular spasticity\ndefinition : A type of spasticity that affects one or more limbs (arms or legs).\nsynonyms :\n'}


{'id': 'HP_0034354', 'url': 'http://purl.obolibrary.org/obo/HP_0034354', 'lbl': 'Trichoschisis', 'desc': 'label: Trichoschisis\ndefinition : Transverse fractures through the hair shafts (trichoschisis). Trichoschisis is characterized by a sharp transverse fracture of the hair shaft.\nsynonyms :\n'}


{'id': 'HP_0034355', 'url': 'http://purl.obolibrary.org/obo/HP_0034355', 'lbl': 'White cerebellum sign', 'desc': 'label: White cerebellum sign\ndefinition : On computed tomography of the brain,the white (or dense) cerebellum sign is seen when the cerebellum appears dense with respect to the cerebral parenchyma. The increase in attenuation of cerebellum is in fact a relative hyperdensity caused by decreased attenutation of the brain. It represents anoxic-ischemic cerebral injury, and has a very poor prognosis.\nsynonyms :\n'}


{'id': 'HP_0034356', 'url': 'http://purl.obolibrary.org/obo/HP_0034356', 'lbl': 'Impaired renal tubular reabsorption of low molecular weight protein', 'desc': 'label: Impaired renal tubular reabsorption of low molecular weight protein\ndefinition : Increased loss of low-molecular weight proteins by the kidneys, measured in terms of the fractional excretion (FE). The FE of low-molecular-weight proteins such as beta2-microglobulin can be measured in terms of plasma and urine concentrations, since urinary low-molecular-weight protein concentrations can vary with water reabsorption.\nsynonyms :Increased low molecular weight protein excretion\n'}


{'id': 'HP_0034357', 'url': 'http://purl.obolibrary.org/obo/HP_0034357', 'lbl': 'Impaired renal tubular reabsorption of glucose', 'desc': 'label: Impaired renal tubular reabsorption of glucose\ndefinition : Increased fractional excretion (FE) of glucose in the urine. The FE of glucose is the percentage of the glucose filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine glucose, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption.\nsynonyms :\n'}


{'id': 'HP_0034358', 'url': 'http://purl.obolibrary.org/obo/HP_0034358', 'lbl': 'Impaired renal tubular reabsorption of sodium', 'desc': 'label: Impaired renal tubular reabsorption of sodium\ndefinition : Increased fractional excretion (FE) of sodium in the urine. The FE of sodium is the percentage of the sodium filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine sodium, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption.\nsynonyms :\n'}


{'id': 'HP_0034359', 'url': 'http://purl.obolibrary.org/obo/HP_0034359', 'lbl': 'Impaired renal tubular reabsorption of phosphate', 'desc': 'label: Impaired renal tubular reabsorption of phosphate\ndefinition : Increased fractional excretion (FE) of glucose in the phosphate. The FE of glucose is the percentage of the phosphate filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine phosphate, rather than by the interpretation of urinary phosphate concentration alone, as urinary glucose concentrations can vary with water reabsorption.\nsynonyms :\n'}


{'id': 'HP_0034360', 'url': 'http://purl.obolibrary.org/obo/HP_0034360', 'lbl': 'Action myoclonus', 'desc': 'label: Action myoclonus\ndefinition : A type of myoclonus (arrhythmic muscular jerking) that is induced by voluntary movement. It is made worse by attempts at precise or coordinated movement (intention myoclonus) and may also be provoked by certain sensory stimuli.\nsynonyms :\n'}


{'id': 'HP_0034361', 'url': 'http://purl.obolibrary.org/obo/HP_0034361', 'lbl': 'Redundant umbilical skin', 'desc': 'label: Redundant umbilical skin\ndefinition : Greater than normal amount of skin surrounding the umbilicus (belly button) with protrusion of the umbilicus above the plane of the abdomen.\nsynonyms :\n'}


{'id': 'HP_0034362', 'url': 'http://purl.obolibrary.org/obo/HP_0034362', 'lbl': 'Dull foveal reflex', 'desc': 'label: Dull foveal reflex\ndefinition : Reduced brigthness of the foveal reflex, which normally is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope.\nsynonyms :Decreased foveal light reflex; Muted foveal light reflex; Poor foveal light reflex\n'}


{'id': 'HP_0034363', 'url': 'http://purl.obolibrary.org/obo/HP_0034363', 'lbl': 'Corneal pterygium', 'desc': "label: Corneal pterygium\ndefinition : Corneal pterygium is an ocular surface disease characterized mainly by a wing-shaped growth of limbal and conjunctival tissue over the adjacent cornea.\nsynonyms :Surfer's eye; Wing-shaped conjunctiva\n"}


{'id': 'HP_0034364', 'url': 'http://purl.obolibrary.org/obo/HP_0034364', 'lbl': 'Fibrofatty replacement of right ventricular myocardium', 'desc': 'label: Fibrofatty replacement of right ventricular myocardium\ndefinition : Replacement of the myocardium of the right ventricular free wall by fat and fibrous tissue.\nsynonyms :\n'}


{'id': 'HP_0034365', 'url': 'http://purl.obolibrary.org/obo/HP_0034365', 'lbl': 'Elevated circulating alpha-aminoadipic semialdehyde concentration', 'desc': 'label: Elevated circulating alpha-aminoadipic semialdehyde concentration\ndefinition : Increased concentration of alpha-aminoadipic semialdehyde in the blood circulation.\nsynonyms :Elevated circulating piperideine-6-carboxylic acid concentration\n'}


{'id': 'HP_0034366', 'url': 'http://purl.obolibrary.org/obo/HP_0034366', 'lbl': 'Fracture blister', 'desc': 'label: Fracture blister\ndefinition : Fracture blister is a type of blister that forms following acute bone fractures, typically near the ankle, wrist elbow or foot, where skin adheres tightly to bone with little subcutaneous fat cushioning. The blister that results resembles that of a second degree burn.\nsynonyms :\n'}


{'id': 'HP_0034367', 'url': 'http://purl.obolibrary.org/obo/HP_0034367', 'lbl': 'Decreased beta-mannosidase activity', 'desc': 'label: Decreased beta-mannosidase activity\ndefinition : Activity of the enzyme beta-mannosidase below the lower limit of normal. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides.\nsynonyms :\n'}


{'id': 'HP_0034368', 'url': 'http://purl.obolibrary.org/obo/HP_0034368', 'lbl': 'Urolithiasis', 'desc': 'label: Urolithiasis\ndefinition : Renal stones are formed within the kidneys, and this is called nephrolithiasis. Urolithiasis is a condition that occurs when these stones exit the renal pelvis and move into the remainder of the urinary collecting system, which includes the ureters, bladder, and urethra.\nsynonyms :\n'}


{'id': 'HP_0034369', 'url': 'http://purl.obolibrary.org/obo/HP_0034369', 'lbl': 'Decreased level of coenzyme Q10 in skeletal muscle', 'desc': 'label: Decreased level of coenzyme Q10 in skeletal muscle\ndefinition : Reduced amount of coenzyme Q10,a naturally occurring quinone, in skeletal muscle tissue.\nsynonyms :\n'}


{'id': 'HP_0034370', 'url': 'http://purl.obolibrary.org/obo/HP_0034370', 'lbl': 'Abnormal muscle tissue metabolite concentration', 'desc': 'label: Abnormal muscle tissue metabolite concentration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034371', 'url': 'http://purl.obolibrary.org/obo/HP_0034371', 'lbl': 'Reduced circulating prekallikrein concentration', 'desc': 'label: Reduced circulating prekallikrein concentration\ndefinition : Reduced concentration of prekallikrein (PK; also known as Fletcher factor) in the blood circulation. PK is the precursor of plasma kallikrein, a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII.\nsynonyms :\n'}


{'id': 'HP_0034372', 'url': 'http://purl.obolibrary.org/obo/HP_0034372', 'lbl': 'Internal tibial torsion', 'desc': 'label: Internal tibial torsion\ndefinition : \nsynonyms :Internal tibial rotation\n'}


{'id': 'HP_0034373', 'url': 'http://purl.obolibrary.org/obo/HP_0034373', 'lbl': 'External tibial torsion', 'desc': 'label: External tibial torsion\ndefinition : External twisting of the tibia resulting in the toes of each foot pointing outward (outtoeing) .\nsynonyms :External tibial rotation\n'}


{'id': 'HP_0034374', 'url': 'http://purl.obolibrary.org/obo/HP_0034374', 'lbl': 'Trident acetabulum', 'desc': 'label: Trident acetabulum\ndefinition : Abnormal appearance of the acetabulum characterized by spurs at the medial and lateral acetabular margin and in the center of the acetabulum, giving rise to shape resembling a three-pronged spear sadi to resemble a trident.\nsynonyms :Trident acetabula\n'}


{'id': 'HP_0034375', 'url': 'http://purl.obolibrary.org/obo/HP_0034375', 'lbl': 'Spherophakia', 'desc': 'label: Spherophakia\ndefinition : Spherophakia is a rare congenital condition that presents with weak zonules around a smaller and more spherical crystalline lens with an increased anteroposterior thickness of the lens, and highly myopic eye. The lens zonules are developmentally hypoplastic and abnormally weak and due to non-attachment of the posterior zonules to the equatorial zone of the lens, the lens changes its normal shape to spherical.\nsynonyms :\n'}


{'id': 'HP_0034376', 'url': 'http://purl.obolibrary.org/obo/HP_0034376', 'lbl': 'Atrioventricular valve regurgitation', 'desc': 'label: Atrioventricular valve regurgitation\ndefinition : Regurgitation of a heart valve that controls blood flow from a an atrium to a ventricle, including mitral, tricuspid, or, rarely, single atrioventicular valve.\nsynonyms :\n'}


{'id': 'HP_0034377', 'url': 'http://purl.obolibrary.org/obo/HP_0034377', 'lbl': 'Single atrioventricular valve regurgitation', 'desc': 'label: Single atrioventricular valve regurgitation\ndefinition : Regurgitation of the single atrioventricular valve regurgitation (AVVR) in the context of a congenital heart defect with a single ventricle. Roughly three quarters of patients following Fontan procedure display AVVR.\nsynonyms :\n'}


{'id': 'HP_0034378', 'url': 'http://purl.obolibrary.org/obo/HP_0034378', 'lbl': 'Urethrovesical occlusion', 'desc': 'label: Urethrovesical occlusion\ndefinition : Blockage of the flow of urine from the bladder into the urethra.\nsynonyms :\n'}


{'id': 'HP_0034379', 'url': 'http://purl.obolibrary.org/obo/HP_0034379', 'lbl': 'obsolete Vascular granular osmiophilic material deposition', 'desc': 'label: obsolete Vascular granular osmiophilic material deposition\ndefinition : Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide.\nsynonyms :\n'}


{'id': 'HP_0034380', 'url': 'http://purl.obolibrary.org/obo/HP_0034380', 'lbl': 'Juvenile type testicular granulosa cell tumor', 'desc': 'label: Juvenile type testicular granulosa cell tumor\ndefinition : Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia.\nsynonyms :\n'}


{'id': 'HP_0034381', 'url': 'http://purl.obolibrary.org/obo/HP_0034381', 'lbl': 'Central nervous system axonal spheroid', 'desc': 'label: Central nervous system axonal spheroid\ndefinition : Axonal spheroids are bubble-like biological features that form on most degenerating axons. During neurodegeneration, bubble-like swellings form along the length of the axon, a primary and early effect of dynamic axonal deformation. These varicosities, spheroids, or swellings have been described as beads on a string and branches bearing fruit, and they frequently appear on degenerating axons. The focal swellings on degenerating axons, axonal spheroids, are often filled with cellular debris such as organelles, pathological proteins, and disorganized cytoskeletal elements.\nsynonyms :CNS axonal spheroid\n'}


{'id': 'HP_0034382', 'url': 'http://purl.obolibrary.org/obo/HP_0034382', 'lbl': 'Disease remission', 'desc': 'label: Disease remission\ndefinition : A decrease in or disappearance of signs and symptoms typically associated with a disease course.\nsynonyms :\n'}


{'id': 'HP_0034383', 'url': 'http://purl.obolibrary.org/obo/HP_0034383', 'lbl': 'Elevated circulating biliverdin concentration', 'desc': 'label: Elevated circulating biliverdin concentration\ndefinition : Increased concentration of biliverdin, a green tetrapyrrolic bile pigment, in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034384', 'url': 'http://purl.obolibrary.org/obo/HP_0034384', 'lbl': 'Elevated circulating insulin:C-peptide ratio', 'desc': 'label: Elevated circulating insulin:C-peptide ratio\ndefinition : Increased ratio of insulin to C-peptide in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034385', 'url': 'http://purl.obolibrary.org/obo/HP_0034385', 'lbl': 'Abnormal left ventricular endsystolic diameter', 'desc': 'label: Abnormal left ventricular endsystolic diameter\ndefinition : A deviation from the normal range of the left ventricular endsystolic diameter.\nsynonyms :\n'}


{'id': 'HP_0034386', 'url': 'http://purl.obolibrary.org/obo/HP_0034386', 'lbl': 'Reduced left ventricular endsystolic diameter', 'desc': 'label: Reduced left ventricular endsystolic diameter\ndefinition : A lower than normal left ventricular endsystolic diameter.\nsynonyms :\n'}


{'id': 'HP_0034387', 'url': 'http://purl.obolibrary.org/obo/HP_0034387', 'lbl': 'Bacterial encephalitis', 'desc': 'label: Bacterial encephalitis\ndefinition : Encephalitis caused by bacterial infection.\nsynonyms :\n'}


{'id': 'HP_0034388', 'url': 'http://purl.obolibrary.org/obo/HP_0034388', 'lbl': 'Hilar lymph node enlargement', 'desc': 'label: Hilar lymph node enlargement\ndefinition : Hilar lymphadenopathy is swelling or enlargement of lymph nodes localised in hila, wedge-shaped anatomical structures containing pulmonary vessels, major bronchi, nerves and lymph nodes. Hilar lymph nodes are not visible on chest X-ray if they are not enlarged. Hilar lymph node enlargement can be caused by benign and malignant conditions and can be symmetrical (bilateral) or asymmetrical (unilateral).\nsynonyms :Hilar lymphadenopathy\n'}


{'id': 'HP_0034389', 'url': 'http://purl.obolibrary.org/obo/HP_0034389', 'lbl': 'Pulmonary vein varix', 'desc': 'label: Pulmonary vein varix\ndefinition : Pulmonary vein varix (PVV), refers to a localised dilatation of a pulmonary vein. PVV is a rare condition and can be congenital or acquired. PVV typically occur at the confluence of the veins adjacent to the left atrium. PVVs are sometimes classified into three morphological types: saccular, tortuous and confluent.\nsynonyms :Pulmonary vein dilatation\n'}


{'id': 'HP_0034390', 'url': 'http://purl.obolibrary.org/obo/HP_0034390', 'lbl': 'Decreased CSF glycine concentration', 'desc': 'label: Decreased CSF glycine concentration\ndefinition : Abnormally decreased levels of glycine in cerebrospinal fluid.\nsynonyms :Glycine low in CSF\n'}


{'id': 'HP_0034391', 'url': 'http://purl.obolibrary.org/obo/HP_0034391', 'lbl': 'Elbow contracture', 'desc': 'label: Elbow contracture\ndefinition : A limitation in the passive range of motion of the elbow resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin.\nsynonyms :\n'}


{'id': 'HP_0034392', 'url': 'http://purl.obolibrary.org/obo/HP_0034392', 'lbl': 'Joint contracture', 'desc': 'label: Joint contracture\ndefinition : A limitation in the passive range of motion of the elbow resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin. A contracture prevents movement of the associated body part.\nsynonyms :Contracture\n'}


{'id': 'HP_0034393', 'url': 'http://purl.obolibrary.org/obo/HP_0034393', 'lbl': 'Elbow extension contracture', 'desc': 'label: Elbow extension contracture\ndefinition : An elbow contracture that limits the ability of the elbow joint to flex (flexion of the the elbow joint refers to bending the elbow joint to bring the hand closer to the shoulder), meaning that the elbow is fixed in an extended (straight) position.\nsynonyms :\n'}


{'id': 'HP_0034394', 'url': 'http://purl.obolibrary.org/obo/HP_0034394', 'lbl': 'Forearm supination contracture', 'desc': 'label: Forearm supination contracture\ndefinition : A contracture that limits the ability of the forearm to stabilize the hand in pronation (pronation refers to a rotation of the forearm that causes the palm and forearm to face downwards), meaning that the palm is fixed in a upward orientation. Restriction of supination/pronation can occur at the elbow (radial-humeral joint), at the wrist (radial-ulnar joint), and anywhere in between.\nsynonyms :Supination contracture of the forearm\n'}


{'id': 'HP_0034395', 'url': 'http://purl.obolibrary.org/obo/HP_0034395', 'lbl': 'Forearm pronation contracture', 'desc': 'label: Forearm pronation contracture\ndefinition : A contracture that limits the ability of the forearm to stabilize the hand in supiation (supination refers to a rotation of the forearm that causes the palm and forearm to face upwards), meaning that the palm is fixed in a downward orientation. Restriction of supination/pronation can occur at the elbow (radial-humeral joint), at the wrist (radial-ulnar joint), and anywhere in between.\nsynonyms :Pronation contracture of the forearm\n'}


{'id': 'HP_0034396', 'url': 'http://purl.obolibrary.org/obo/HP_0034396', 'lbl': 'Hippocampal malrotation', 'desc': 'label: Hippocampal malrotation\ndefinition : Hippocampal malrotation, also termed incomplete inversion of the hippocampus or hippocampal malformation, is an increasingly recognized neuroimaging finding of undetermined clinical significance. It is characterized by features including (i) Round or pyramidal shape instead of ovoid shape; (ii) Medial position of the hippocampus on the hippocampal sulcus; (iii) The collateral sulcus is excessively deep or verticalized; (iv) Fimbria located medial to the hippocampus; (v) Small or displaced fornix; (vi) Enlarged temporal horn and empty choroid fissure; (vii) Thickened subiculum; (viii) Reduced upper horizontal portion of the parahippocampal gyrus.\nsynonyms :\n'}


{'id': 'HP_0034397', 'url': 'http://purl.obolibrary.org/obo/HP_0034397', 'lbl': 'Claw toe deformity', 'desc': 'label: Claw toe deformity\ndefinition : Claw toes are characterized by hyperextension at the metatarsal-phalangeal joints and flexion of the interphalangeal joints.\nsynonyms :\n'}


{'id': 'HP_0034398', 'url': 'http://purl.obolibrary.org/obo/HP_0034398', 'lbl': 'Toe deformity', 'desc': 'label: Toe deformity\ndefinition : Abnormal positioning of toe phalanges. Deformities of the lesser toes often occur gradually, though they can be brought on by trauma. The main adult sagittal plane deformities consist of claw toes, hammer toes and mallet toes. Axial plane deformities include crossover toes.\nsynonyms :\n'}


{'id': 'HP_0034399', 'url': 'http://purl.obolibrary.org/obo/HP_0034399', 'lbl': 'Prolonged central motor conduction time', 'desc': 'label: Prolonged central motor conduction time\ndefinition : Increased duration of the central motor conduction time (CMCT). The CMCT estimates the conduction time of corticospinal fibers between motor cortex and spinal (or bulbar) motoneurons. It includes the times for excitation of cortical cells, conduction via the corticobulbar-corticospinal tract and excitation of the motoneuron sufficient to reach its firing threshold. CMCT is calculated by subtracting the peripheral conduction time from the MEP latency recorded after cortical stimulation.\nsynonyms :\n'}


{'id': 'HP_0034400', 'url': 'http://purl.obolibrary.org/obo/HP_0034400', 'lbl': 'Circumferential skin creases on extremities', 'desc': 'label: Circumferential skin creases on extremities\ndefinition : Ringed creases of the skin of the extremities related to folding of excess skin.\nsynonyms :\n'}


{'id': 'HP_0034401', 'url': 'http://purl.obolibrary.org/obo/HP_0034401', 'lbl': 'Atypical teratoid/rhabdoid tumor', 'desc': 'label: Atypical teratoid/rhabdoid tumor\ndefinition : An aggressive malignant embryonal neoplasm arising from the central nervous system. It is composed of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm. Mutations of the SMARCB1 gene or very rarely SMARCA4 (BRG1) gene are present. The vast majority of cases occur in childhood. Symptoms include lethargy, vomiting, cranial nerve palsy, headache, and hemiplegia.\nsynonyms :\n'}


{'id': 'HP_0034402', 'url': 'http://purl.obolibrary.org/obo/HP_0034402', 'lbl': 'Rhabdoid tumor of the kidney', 'desc': 'label: Rhabdoid tumor of the kidney\ndefinition : A highly aggressive, extremely rare neoplasm of the kidney that is usually seen in children. The term rhabdoid is used because the tumor cells resemble rhabdomyoblasts but lack myogenic markers, and pathologic diagnosis requires familiarity with these microscopic features plus awareness that adult onset is possible. It can be associated with abnormalities of chromosome 22. It is characterized by the presence of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm.\nsynonyms :Malignant rhabdoid tumor of the kidney\n'}


{'id': 'HP_0034403', 'url': 'http://purl.obolibrary.org/obo/HP_0034403', 'lbl': 'Subcutaneous panniculitis-like T-cell lymphoma', 'desc': 'label: Subcutaneous panniculitis-like T-cell lymphoma\ndefinition : A form of T-cell non-Hodgkin lymphoma in which cytotoxic CD8+ T cells infiltrate adipose tissue forming subcutaneous nodules.\nsynonyms :\n'}


{'id': 'HP_0034404', 'url': 'http://purl.obolibrary.org/obo/HP_0034404', 'lbl': 'Fungal hyphae in sputum', 'desc': 'label: Fungal hyphae in sputum\ndefinition : Presence of hyphae (long, branching, filamentous structures produced by fungi) in sputum.\nsynonyms :\n'}


{'id': 'HP_0034405', 'url': 'http://purl.obolibrary.org/obo/HP_0034405', 'lbl': 'Enlarged tectum', 'desc': 'label: Enlarged tectum\ndefinition : Increasaed size of the tectum, which is the region of the midbrain posterior to the cerebral aqueduct of Sylvius. The midbrain is the most superior portion of the brainstem.\nsynonyms :Thick tectum\n'}


{'id': 'HP_0034406', 'url': 'http://purl.obolibrary.org/obo/HP_0034406', 'lbl': 'Elevated CSF angiotensin-converting enzyme concentration', 'desc': 'label: Elevated CSF angiotensin-converting enzyme concentration\ndefinition : \nsynonyms :Angiotensin-converting enzyme (ACE) high in CSF\n'}


{'id': 'HP_0034407', 'url': 'http://purl.obolibrary.org/obo/HP_0034407', 'lbl': 'Reduced circulating 3-ketoacyl-CoA thiolase concentration', 'desc': 'label: Reduced circulating 3-ketoacyl-CoA thiolase concentration\ndefinition : Decreased concentration of 3-ketoacyl-CoA thiolase in th blood circulation.\nsynonyms :3-ketoacyl-CoA thiolase (THIO) deficiency\n'}


{'id': 'HP_0034408', 'url': 'http://purl.obolibrary.org/obo/HP_0034408', 'lbl': 'Solitary angiokeratoma', 'desc': 'label: Solitary angiokeratoma\ndefinition : A dark, keratotic papule about 2-10 mm in diameter, usually occuring on the lower extremeities. Usually the lesions begin as bright, soft, and nonkeratotic paules which grow larger and change to a firm, blue to black and keratotic stage.\nsynonyms :\n'}


{'id': 'HP_0034409', 'url': 'http://purl.obolibrary.org/obo/HP_0034409', 'lbl': 'Fordyce angiokeratoma', 'desc': 'label: Fordyce angiokeratoma\ndefinition : A type of angiokeratoma that most commonly occurs on the scrotum of patients who are 40 years old or older. The typical single lesion is a dark red to blue dome-shaped papule 2-4 mm in diameter with a very discrete keratotic surface. Typically, they are multiple and arranged in a line parallel to the raphe mediana of the scrotum. They also occur on the vulva and less commnly on the penis.\nsynonyms :\n'}


{'id': 'HP_0034410', 'url': 'http://purl.obolibrary.org/obo/HP_0034410', 'lbl': 'Angiokeratoma circumscriptum naeviforme', 'desc': 'label: Angiokeratoma circumscriptum naeviforme\ndefinition : A type of angiokeratoma that typically presents in childhood as a large, mostly linear and unilateral hyperkeratotic plaque which is composed of confluent keratotic papules. The size ranges from a few centimeters up to a major part of the body surface. Initially the lesions present asa multile reddish macules, clinically similar to a nevus flammeus. Within several years they develop into acanthokeratotic papules that agrregate into plaques which may have a hyperkeratotic surface.\nsynonyms :\n'}


{'id': 'HP_0034411', 'url': 'http://purl.obolibrary.org/obo/HP_0034411', 'lbl': 'Angiokeratoma of Mibelli', 'desc': 'label: Angiokeratoma of Mibelli\ndefinition : A type of angiokeratoma that typically presents in women on the dorsa of fingers and toes and multiple dark red papules with a slightly verrucous surface, each measuring about 3-5 mm in diameter.\nsynonyms :\n'}


{'id': 'HP_0034412', 'url': 'http://purl.obolibrary.org/obo/HP_0034412', 'lbl': 'Laryngeal mass', 'desc': 'label: Laryngeal mass\ndefinition : A lump in the region of the larynx. A mass is any lump in the body that can be caused by the abnormal growth of cells, a cyst, hormonal changes or an immune reaction. Typically a mass is an initial finding that will lead to additional workup. Laryngeal masses can be visualized by multiple methods include computed tomography.\nsynonyms :\n'}


{'id': 'HP_0034413', 'url': 'http://purl.obolibrary.org/obo/HP_0034413', 'lbl': 'Palate mass', 'desc': 'label: Palate mass\ndefinition : A lump in the region of the palate. A mass is any lump in the body that can be caused by the abnormal growth of cells, a cyst, hormonal changes or an immune reaction. Typically a mass is an initial finding that will lead to additional workup.\nsynonyms :\n'}


{'id': 'HP_0034414', 'url': 'http://purl.obolibrary.org/obo/HP_0034414', 'lbl': 'Thick oral frenulum', 'desc': 'label: Thick oral frenulum\ndefinition : Increased thickness of an oral frenulum, flaps of mucous membrane that extend from the midline gingiva to the upper or lower lip.\nsynonyms :oral frenulum, thick\n'}


{'id': 'HP_0034415', 'url': 'http://purl.obolibrary.org/obo/HP_0034415', 'lbl': 'Tooth avulsion', 'desc': 'label: Tooth avulsion\ndefinition : A type of dental trauma characterized by total dislocation of the tooth from its socket.\nsynonyms :Avulsed tooth; Teeth: avulsion\n'}


{'id': 'HP_0034416', 'url': 'http://purl.obolibrary.org/obo/HP_0034416', 'lbl': 'Torn oral frenulum', 'desc': 'label: Torn oral frenulum\ndefinition : Laceration or tear of an oral frenulum, flaps of mucous membrane that extend from the midline gingiva to the upper or lower lip.\nsynonyms :Laceration of oral frenulum; Oral frenulum, torn\n'}


{'id': 'HP_0034417', 'url': 'http://purl.obolibrary.org/obo/HP_0034417', 'lbl': 'Intraoral laceration', 'desc': 'label: Intraoral laceration\ndefinition : A wound of the mucosa within the oral cavity covering lips, tongue, palate, gingiva, pharynx, or retropharynx.\nsynonyms :Intraoral lacerations\n'}


{'id': 'HP_0034418', 'url': 'http://purl.obolibrary.org/obo/HP_0034418', 'lbl': 'Erythematous oral mucosa', 'desc': 'label: Erythematous oral mucosa\ndefinition : An erythematous lesion of the oral mucosa may result from a variety of tissue alterations, including inflammation, erythrocyte extravasation, and atrophy or reduced keratinization of the surface epithelium.\nsynonyms :Oral mucosa erythema\n'}


{'id': 'HP_0034419', 'url': 'http://purl.obolibrary.org/obo/HP_0034419', 'lbl': 'Mitral chordae tendinae rupture', 'desc': 'label: Mitral chordae tendinae rupture\ndefinition : Breakage of the chordae tendinae of the mitral valve. This can lead to loss of tension of one of the mitral valve leaflets and mitral regurgitation.\nsynonyms :\n'}


{'id': 'HP_0034420', 'url': 'http://purl.obolibrary.org/obo/HP_0034420', 'lbl': 'History of cardiovascular procedure', 'desc': 'label: History of cardiovascular procedure\ndefinition : Indicates that a cardiovascular procedure such as stenting, bypass, catherization was performed on a patient.\nsynonyms :\n'}


{'id': 'HP_0034421', 'url': 'http://purl.obolibrary.org/obo/HP_0034421', 'lbl': 'Ejection click', 'desc': 'label: Ejection click\ndefinition : A high-pitched sound that occurs at the moment of maximal opening of the aortic or pulmonary valves. They are heard just after the first heart sound. The sounds occur in the presence of a dilated aorta or pulmonary artery or in the presence of a bicuspid or flexible stenotic aortic or pulmonary valve. Ejection clicks may also be called ejection sounds.\nsynonyms :Cardiac click sound on auscultation\n'}


{'id': 'HP_0034422', 'url': 'http://purl.obolibrary.org/obo/HP_0034422', 'lbl': 'Cryofibrinogenemia', 'desc': 'label: Cryofibrinogenemia\ndefinition : Cryofibrinogen is an abnormal protein that forms precipitate only in plasma. consisting of fibrinogen, fibronectin, alpha1-antitrypsin and alpha2-macroglobulin.\nsynonyms :\n'}


{'id': 'HP_0034423', 'url': 'http://purl.obolibrary.org/obo/HP_0034423', 'lbl': 'triggered by allergens', 'desc': 'label: triggered by allergens\ndefinition : Applies to a sign or symptom that is provoked or brought about by exposure to allergens.\nsynonyms :\n'}


{'id': 'HP_0034424', 'url': 'http://purl.obolibrary.org/obo/HP_0034424', 'lbl': 'Clicking tinnitus', 'desc': 'label: Clicking tinnitus\ndefinition : A type of tinnitus that presents as clicks, resembling the noise made by the snapping together of 2 fingers.\nsynonyms :\n'}


{'id': 'HP_0034425', 'url': 'http://purl.obolibrary.org/obo/HP_0034425', 'lbl': 'Reduced hair sulfur content', 'desc': 'label: Reduced hair sulfur content\ndefinition : Abnormally low amount of sulfur in hair.\nsynonyms :Hair sulfur content reduced\n'}


{'id': 'HP_0034426', 'url': 'http://purl.obolibrary.org/obo/HP_0034426', 'lbl': 'Chromhidrosis', 'desc': 'label: Chromhidrosis\ndefinition : Secretion of colored sweat.\nsynonyms :\n'}


{'id': 'HP_0034427', 'url': 'http://purl.obolibrary.org/obo/HP_0034427', 'lbl': 'Purulent eye discharge', 'desc': 'label: Purulent eye discharge\ndefinition : Secretion of pus-like (purulent) material from the eye, which may caused the eyelids to be matted together.\nsynonyms :Mucopurulent discharge from the eye\n'}


{'id': 'HP_0034428', 'url': 'http://purl.obolibrary.org/obo/HP_0034428', 'lbl': 'Megaloblepharon', 'desc': 'label: Megaloblepharon\ndefinition : Disproportionately large eyelids\nsynonyms :\n'}


{'id': 'HP_0034429', 'url': 'http://purl.obolibrary.org/obo/HP_0034429', 'lbl': 'Bacteria in cerebrospinal fluid', 'desc': 'label: Bacteria in cerebrospinal fluid\ndefinition : Presence of bacteria in the cerebrospinal fluid, as manifested by visual inspection or bacterial culture results.\nsynonyms :Bacteria in CSF\n'}


{'id': 'HP_0034430', 'url': 'http://purl.obolibrary.org/obo/HP_0034430', 'lbl': 'Abnormal joint physiology', 'desc': 'label: Abnormal joint physiology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034431', 'url': 'http://purl.obolibrary.org/obo/HP_0034431', 'lbl': 'Joint crepitus', 'desc': 'label: Joint crepitus\ndefinition : A popping, clicking or crackling sound that accompaniees movement of a joint.\nsynonyms :\n'}


{'id': 'HP_0034432', 'url': 'http://purl.obolibrary.org/obo/HP_0034432', 'lbl': 'Intertriginous distribution', 'desc': 'label: Intertriginous distribution\ndefinition : Applies to the localization of a skin lesion involving any area of the body where two opposing skin surfaces can touch and rub or chaff.\nsynonyms :Intertriginous distribution of skin lesions\n'}


{'id': 'HP_0034433', 'url': 'http://purl.obolibrary.org/obo/HP_0034433', 'lbl': 'Distributed along skin tension lines', 'desc': "label: Distributed along skin tension lines\ndefinition : Applies to the localization of a skin lesion that correspond to skin tension lines, which are linear clefts in the skin that indicate the direction of orientation of the underlying collagen fibers. Skin tension lines are also known as Langer's lines or lines of cleavage.\nsynonyms :Distributed along Langer's lines; Lesions follow lines of cleavage\n"}


{'id': 'HP_0034434', 'url': 'http://purl.obolibrary.org/obo/HP_0034434', 'lbl': 'Abnormal communication', 'desc': 'label: Abnormal communication\ndefinition : Any abnormal behavior related to communication.\nsynonyms :\n'}


{'id': 'HP_0034435', 'url': 'http://purl.obolibrary.org/obo/HP_0034435', 'lbl': 'Abnormal eye contact', 'desc': 'label: Abnormal eye contact\ndefinition : Any abnormality of eye contact behavior. We define eye contact as a form of nonverbal communication between two individuals who are facing each other in which an individual directs the eyes towards the eyes or face of the other individual. Eye contact occurs frequently and voluntarily during face-to-face verbal communication. The duration and frequency of eye contact that is interpreted to be appropriate may follow social and situational norms.\nsynonyms :\n'}


{'id': 'HP_0034436', 'url': 'http://purl.obolibrary.org/obo/HP_0034436', 'lbl': 'Gaze avoidance', 'desc': 'label: Gaze avoidance\ndefinition : A deliberate avoidance of eye contact.\nsynonyms :Gaze aversion\n'}


{'id': 'HP_0034437', 'url': 'http://purl.obolibrary.org/obo/HP_0034437', 'lbl': 'Excessive eye contact', 'desc': 'label: Excessive eye contact\ndefinition : Tendency to maintain sustained eye contact for an inappropriately long period of time.\nsynonyms :\n'}


{'id': 'HP_0034438', 'url': 'http://purl.obolibrary.org/obo/HP_0034438', 'lbl': 'Balanitis', 'desc': 'label: Balanitis\ndefinition : Inflammation of glans penis\nsynonyms :\n'}


{'id': 'HP_0034439', 'url': 'http://purl.obolibrary.org/obo/HP_0034439', 'lbl': 'Instep location', 'desc': 'label: Instep location\ndefinition : Applies to an abnormality that is situated in the arched middle portion of the foot in front of the ankle joint (i.e., instep).\nsynonyms :Instep localization to skin abnormality\n'}


{'id': 'HP_0034440', 'url': 'http://purl.obolibrary.org/obo/HP_0034440', 'lbl': 'Ameliorated by ultraviolet light exposure', 'desc': 'label: Ameliorated by ultraviolet light exposure\ndefinition : Applies to a skin lesion that is improved or made more bearable by exposure to ultraviolet light (sunshine or phototherapy).\nsynonyms :Ultraviolet exposure improves condition\n'}


{'id': 'HP_0034441', 'url': 'http://purl.obolibrary.org/obo/HP_0034441', 'lbl': 'Decreased circulating aspartic acid concentration', 'desc': 'label: Decreased circulating aspartic acid concentration\ndefinition : An reduced concentration of aspartic acid in the blood circulation.\nsynonyms :Aspartic acid low in blood\n'}


{'id': 'HP_0034442', 'url': 'http://purl.obolibrary.org/obo/HP_0034442', 'lbl': 'Abnormal circulating erythropoietin concentration', 'desc': 'label: Abnormal circulating erythropoietin concentration\ndefinition : Any deviation from the normal concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production.\nsynonyms :\n'}


{'id': 'HP_0034443', 'url': 'http://purl.obolibrary.org/obo/HP_0034443', 'lbl': 'Reduced circulating erythropoietin concentration', 'desc': 'label: Reduced circulating erythropoietin concentration\ndefinition : Decreased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production.\nsynonyms :Erythropoietin low in blood\n'}


{'id': 'HP_0034444', 'url': 'http://purl.obolibrary.org/obo/HP_0034444', 'lbl': 'Abnormal gamma-glutamyltransferase level', 'desc': 'label: Abnormal gamma-glutamyltransferase level\ndefinition : Any deviation from the normal level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.\nsynonyms :\n'}


{'id': 'HP_0034445', 'url': 'http://purl.obolibrary.org/obo/HP_0034445', 'lbl': 'Reduced gamma-glutamyltransferase level', 'desc': 'label: Reduced gamma-glutamyltransferase level\ndefinition : Decreased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.\nsynonyms :Gamma-glutamyl transferase low in blood\n'}


{'id': 'HP_0034446', 'url': 'http://purl.obolibrary.org/obo/HP_0034446', 'lbl': 'Elevated circulating histamine concentration', 'desc': 'label: Elevated circulating histamine concentration\ndefinition : Increased concentration of histamine in the blood circulation.\nsynonyms :Histamine high in blood\n'}


{'id': 'HP_0034447', 'url': 'http://purl.obolibrary.org/obo/HP_0034447', 'lbl': 'Increased circulating interleukin 18 concentration', 'desc': 'label: Increased circulating interleukin 18 concentration\ndefinition : An increased concentration of interleukin-18 in the blood circulation.\nsynonyms :IL-18 high in blood\n'}


{'id': 'HP_0034448', 'url': 'http://purl.obolibrary.org/obo/HP_0034448', 'lbl': 'Abnormal phytanic acid:pristanic acid ratio', 'desc': 'label: Abnormal phytanic acid:pristanic acid ratio\ndefinition : Any deviation from the normal ratio of blood phytanic acid concentration to pristanic acid concentration.\nsynonyms :Abnormal phytanic acid to pristanic acid ratio; Abnormal phytanic acid/pristanic acid ratio\n'}


{'id': 'HP_0034449', 'url': 'http://purl.obolibrary.org/obo/HP_0034449', 'lbl': 'Increased phytanic acid:pristanic acid ratio', 'desc': 'label: Increased phytanic acid:pristanic acid ratio\ndefinition : An elevation above the normal ratio of blood phytanic acid concentration to pristanic acid concentration.\nsynonyms :Phytanic acid to pristanic acid ratio high\n'}


{'id': 'HP_0034450', 'url': 'http://purl.obolibrary.org/obo/HP_0034450', 'lbl': 'Decreased phytanic acid:pristanic acid ratio', 'desc': 'label: Decreased phytanic acid:pristanic acid ratio\ndefinition : A reduction below the normal ratio of blood phytanic acid concentration to pristanic acid concentration.\nsynonyms :Phytanic acid to pristanic acid ratio low\n'}


{'id': 'HP_0034451', 'url': 'http://purl.obolibrary.org/obo/HP_0034451', 'lbl': 'Rectovesical fistula', 'desc': 'label: Rectovesical fistula\ndefinition : An aberrant, pathological communication between the rectum and the bladder.\nsynonyms :Vesicorectal fistula\n'}


{'id': 'HP_0034452', 'url': 'http://purl.obolibrary.org/obo/HP_0034452', 'lbl': 'Rectoureteral fistula', 'desc': 'label: Rectoureteral fistula\ndefinition : An abnormal connection (fistula) between the rectum and the ureter.\nsynonyms :\n'}


{'id': 'HP_0034453', 'url': 'http://purl.obolibrary.org/obo/HP_0034453', 'lbl': 'Hypoplastic umbilicus', 'desc': 'label: Hypoplastic umbilicus\ndefinition : Underdevelopment of the umbilicus.\nsynonyms :Umbilicus hypoplastic\n'}


{'id': 'HP_0034454', 'url': 'http://purl.obolibrary.org/obo/HP_0034454', 'lbl': 'Arachnoid granulation', 'desc': 'label: Arachnoid granulation\ndefinition : Arachnoid granulations (AGs) are tufts of arachnoid membrane invaginated into the dural sinuses through which cerebrospinal fluid (CSF) enters the venous system. The lesions are primarily located in the parasagittal region along the superior sagittal sinus, which is occasionally seen at the transverse sinus. Normally dural venous sinus AGs typically range from 2 to 8 mm in size, but may grow enough to expand the dural sinuses, and even the inner table, diploic space and outer table of the skull.\nsynonyms :\n'}


{'id': 'HP_0034455', 'url': 'http://purl.obolibrary.org/obo/HP_0034455', 'lbl': 'Increased CSF taurine concentration', 'desc': 'label: Increased CSF taurine concentration\ndefinition : Increased concentration of taurine in the cerebrospinal fluid (CSF).\nsynonyms :Taurine high in CSF\n'}


{'id': 'HP_0034456', 'url': 'http://purl.obolibrary.org/obo/HP_0034456', 'lbl': 'Elevated circulating glutathione concentration', 'desc': 'label: Elevated circulating glutathione concentration\ndefinition : An abnormally increased level of glutathione in the blood circulation.\nsynonyms :Glutathione high in blood\n'}


{'id': 'HP_0034457', 'url': 'http://purl.obolibrary.org/obo/HP_0034457', 'lbl': 'Hawkinsinuria', 'desc': 'label: Hawkinsinuria\ndefinition : Increased level of hawkinsin in the urine. Hawkinsin is a cysteine derivative that is cysteine in which the thiol group is substituted by a [2-(carboxymethyl)-2,5-dihydroxycyclohex-3-en-1-yl]sulfanediyl group.\nsynonyms :Hawkinsin high in urine\n'}


{'id': 'HP_0034458', 'url': 'http://purl.obolibrary.org/obo/HP_0034458', 'lbl': 'Elevated urinary phenylpyruvic acid level', 'desc': 'label: Elevated urinary phenylpyruvic acid level\ndefinition : An abnormally increased amount of phenylpyruvic acid in the urine.\nsynonyms :Phenylpyruvic acid high in urine\n'}


{'id': 'HP_0034459', 'url': 'http://purl.obolibrary.org/obo/HP_0034459', 'lbl': 'Ameliorated by lumbar puncture', 'desc': 'label: Ameliorated by lumbar puncture\ndefinition : Applies to a sign or symptom that is improved or made more bearable by lumbar puncture.\nsynonyms :Lumbar puncture relieves symptoms\n'}


{'id': 'HP_0034460', 'url': 'http://purl.obolibrary.org/obo/HP_0034460', 'lbl': 'Increased CSF uracil concentration', 'desc': 'label: Increased CSF uracil concentration\ndefinition : An increased level of uracil in the cerebrospinal fluid.\nsynonyms :\n'}


{'id': 'HP_0034461', 'url': 'http://purl.obolibrary.org/obo/HP_0034461', 'lbl': 'Elevated urine kynurenine level', 'desc': 'label: Elevated urine kynurenine level\ndefinition : An abnormally increased amount of kynurenine in the urine.\nsynonyms :Kynurenine high in urine\n'}


{'id': 'HP_0034462', 'url': 'http://purl.obolibrary.org/obo/HP_0034462', 'lbl': 'Increased CSF L-alloisoleucine concentration', 'desc': 'label: Increased CSF L-alloisoleucine concentration\ndefinition : An abnormally increased concentration of L-alloisoleucine in the cerebrospinal fluid (CSF).\nsynonyms :L-alloisoleucine high in CSF\n'}


{'id': 'HP_0034463', 'url': 'http://purl.obolibrary.org/obo/HP_0034463', 'lbl': 'Hydroxylysinemia', 'desc': 'label: Hydroxylysinemia\ndefinition : An increased concentration of hydroxylysine in the blood circulation. Hydroxylysine arises from a post-translational hydroxy modification of lysine and is unique to collagen and proteins containing collagen-like sequences. Elevated concentrations of hydroxylysine may indicate increased bone turnover.\nsynonyms :Hydroxylysine present in blood\n'}


{'id': 'HP_0034464', 'url': 'http://purl.obolibrary.org/obo/HP_0034464', 'lbl': 'Homocitrullinuria', 'desc': 'label: Homocitrullinuria\ndefinition : An increased amount of L-homocitrulline in the urine. L-homocitrulline is an L-lysine derivative that is L-lysine having a carbamoyl group at the N(6)-position. It is found in individuals with urea cycle disorders.\nsynonyms :Homocitrulline present in urine\n'}


{'id': 'HP_0034465', 'url': 'http://purl.obolibrary.org/obo/HP_0034465', 'lbl': '2-hydroxyadipic aciduria', 'desc': 'label: 2-hydroxyadipic aciduria\ndefinition : An increase in the level of 2-hydroxyadipic acid in the urine.\nsynonyms :2-hydroxyadipic acid high in urine\n'}


{'id': 'HP_0034466', 'url': 'http://purl.obolibrary.org/obo/HP_0034466', 'lbl': 'Homoargininuria', 'desc': 'label: Homoargininuria\ndefinition : An increased amount of homoarginine in the urine. Homoarginine is a nonproteinogenic alpha amino acid.\nsynonyms :Homoarginine high in urine\n'}


{'id': 'HP_0034467', 'url': 'http://purl.obolibrary.org/obo/HP_0034467', 'lbl': 'Increased urinary cysteine level', 'desc': 'label: Increased urinary cysteine level\ndefinition : An increased concentration of cysteine in the urine.\nsynonyms :\n'}


{'id': 'HP_0034468', 'url': 'http://purl.obolibrary.org/obo/HP_0034468', 'lbl': 'Gastric xanthoma', 'desc': 'label: Gastric xanthoma\ndefinition : Gastric xanthomas (also known as xanthelasmas) are are plaque-like red lesions defined by the presence of histiocytic containing lipids.\nsynonyms :Gastric xanthomas; Gastric xanthomata\n'}


{'id': 'HP_0034469', 'url': 'http://purl.obolibrary.org/obo/HP_0034469', 'lbl': 'Decreased stool elastase level', 'desc': 'label: Decreased stool elastase level\ndefinition : Reduced amount of pancreatic elastase in the stool. This feature may be observed with pancreatic insufficiency.\nsynonyms :Elastase low in stool\n'}


{'id': 'HP_0034470', 'url': 'http://purl.obolibrary.org/obo/HP_0034470', 'lbl': 'Elevated stool chloride content', 'desc': 'label: Elevated stool chloride content\ndefinition : Elevated amount of chloride in the stool.\nsynonyms :Chloride high in stool; Elevations in fecal chloride concentration\n'}


{'id': 'HP_0034471', 'url': 'http://purl.obolibrary.org/obo/HP_0034471', 'lbl': 'Increased fecal coproporphyrin III:coproporphyrin I ratio', 'desc': 'label: Increased fecal coproporphyrin III:coproporphyrin I ratio\ndefinition : Abnormal relative increase in the amount of fecal coproporphyrin III as compared to coproporphyrin I in the feces.\nsynonyms :Coproporphyrin isomer III/I ratio high in stool; Increased fecal CIII:CI ratio\n'}


{'id': 'HP_0034472', 'url': 'http://purl.obolibrary.org/obo/HP_0034472', 'lbl': 'Increased fecal harderoporphyrin', 'desc': 'label: Increased fecal harderoporphyrin\ndefinition : Abnormally high concentration of harderoporphyrin in feces.\nsynonyms :Harderoporphyrin high in stool\n'}


{'id': 'HP_0034473', 'url': 'http://purl.obolibrary.org/obo/HP_0034473', 'lbl': 'Increased fecal heptacarboxylporphyrin', 'desc': 'label: Increased fecal heptacarboxylporphyrin\ndefinition : Abnormally high concentration of heptacarboxylporphyrin in feces.\nsynonyms :Heptacarboxylporphyrin high in stool\n'}


{'id': 'HP_0034474', 'url': 'http://purl.obolibrary.org/obo/HP_0034474', 'lbl': 'Increased fecal pentacarboxylporphyrin', 'desc': 'label: Increased fecal pentacarboxylporphyrin\ndefinition : Abnormally high concentration of pentacarboxylporphyrin in feces.\nsynonyms :Pentacarboxylporphyrin high in stool\n'}


{'id': 'HP_0034475', 'url': 'http://purl.obolibrary.org/obo/HP_0034475', 'lbl': 'Increased fecal isocoproporphyrin', 'desc': 'label: Increased fecal isocoproporphyrin\ndefinition : Abnormally high concentration of isocoproporphyrin in feces.\nsynonyms :Isocoproporphyrin high in stool\n'}


{'id': 'HP_0034476', 'url': 'http://purl.obolibrary.org/obo/HP_0034476', 'lbl': 'Positive fecal Clostridium botulinum test', 'desc': 'label: Positive fecal Clostridium botulinum test\ndefinition : Identification of Clostridium botulinum toxin in the feces.\nsynonyms :Clostridium botulinum toxin in stool\n'}


{'id': 'HP_0034477', 'url': 'http://purl.obolibrary.org/obo/HP_0034477', 'lbl': 'Perihepatic adhesions', 'desc': 'label: Perihepatic adhesions\ndefinition : Abnormal union of the membranous surfaces of the liver capsule and the parietal peritoneum due to inflammation or injury. Adhesions may be visualized by laparoscopy and may have a violin string appearance.\nsynonyms :Peri-hepatic adhesions\n'}


{'id': 'HP_0034478', 'url': 'http://purl.obolibrary.org/obo/HP_0034478', 'lbl': 'Dilated vas deferens', 'desc': 'label: Dilated vas deferens\ndefinition : Abnormal increase in diameter (expansion) of the vas deferens.\nsynonyms :Vas deferens dilated\n'}


{'id': 'HP_0034479', 'url': 'http://purl.obolibrary.org/obo/HP_0034479', 'lbl': 'Enlarged epididymis', 'desc': 'label: Enlarged epididymis\ndefinition : Abnormal increase in the size of the epididymis.\nsynonyms :Epididymis enlarged\n'}


{'id': 'HP_0034480', 'url': 'http://purl.obolibrary.org/obo/HP_0034480', 'lbl': 'Absent epididymidis', 'desc': 'label: Absent epididymidis\ndefinition : \nsynonyms :Absent epididymides; Epididymides absent\n'}


{'id': 'HP_0034481', 'url': 'http://purl.obolibrary.org/obo/HP_0034481', 'lbl': 'Atypical gestures', 'desc': 'label: Atypical gestures\ndefinition : Spontaneous production of communicative gestures that are perceived as odd or mechanical, or are poorly integrated with other means of communication. This may include inaccurate mimicry of typical gestures.\nsynonyms :\n'}


{'id': 'HP_0034482', 'url': 'http://purl.obolibrary.org/obo/HP_0034482', 'lbl': 'Abnormal spinal cord physiology', 'desc': 'label: Abnormal spinal cord physiology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034483', 'url': 'http://purl.obolibrary.org/obo/HP_0034483', 'lbl': 'Bone marrow vacuolated lymphocytes', 'desc': 'label: Bone marrow vacuolated lymphocytes\ndefinition : The presence of lymphocytes with multilple vacuoles (a membrane-bound cell organelle) in the bone marrow.\nsynonyms :Bone marrow: vacuolated lymphocytes\n'}


{'id': 'HP_0034484', 'url': 'http://purl.obolibrary.org/obo/HP_0034484', 'lbl': 'Spinal cord calcifications', 'desc': 'label: Spinal cord calcifications\ndefinition : The presence of calcium deposition in the spinal cord.\nsynonyms :\n'}


{'id': 'HP_0034485', 'url': 'http://purl.obolibrary.org/obo/HP_0034485', 'lbl': 'Neuroepithelial cyst', 'desc': 'label: Neuroepithelial cyst\ndefinition : A benign epithelial-lined cystic lesion that can occur anywhere in the neuraxis. Neuroepithelial cysts are ependymal or epithelial lined fluid collections of unknown etiology within the central nervous system parenchyma with no obvious ventricular or subarachnoid connection. Most cysts are asymptomatic, however, some present with seizures, mass effect, or rarely with movement disorders. On imaging, they present as CSF-like parenchymal cysts with smooth, rounded borders and minimal or no surrounding signal intensity abnormality.\nsynonyms :Glioependymal cyst; Neuroglial cyst\n'}


{'id': 'HP_0034486', 'url': 'http://purl.obolibrary.org/obo/HP_0034486', 'lbl': 'Reduced circulating interleukin 7 concentration', 'desc': 'label: Reduced circulating interleukin 7 concentration\ndefinition : A diminished concentration of interleukin-7 in the circulation.\nsynonyms :IL-7 low in blood\n'}


{'id': 'HP_0034487', 'url': 'http://purl.obolibrary.org/obo/HP_0034487', 'lbl': 'Increased circulating interleukin 12 concentration', 'desc': 'label: Increased circulating interleukin 12 concentration\ndefinition : An increased concentration of interleukin-12 in the blood circulation.\nsynonyms :IL-12 high in blood\n'}


{'id': 'HP_0034488', 'url': 'http://purl.obolibrary.org/obo/HP_0034488', 'lbl': 'Increased circulating interleukin 13 concentration', 'desc': 'label: Increased circulating interleukin 13 concentration\ndefinition : An increased concentration of interleukin-13 in the blood circulation.\nsynonyms :IL-13 high in blood\n'}


{'id': 'HP_0034489', 'url': 'http://purl.obolibrary.org/obo/HP_0034489', 'lbl': 'Increased circulating interleukin 2 concentration', 'desc': 'label: Increased circulating interleukin 2 concentration\ndefinition : An increased concentration of interleukin-2 in the blood circulation.\nsynonyms :IL-2 high in blood\n'}


{'id': 'HP_0034490', 'url': 'http://purl.obolibrary.org/obo/HP_0034490', 'lbl': 'Increased circulating interleukin 4 concentration', 'desc': 'label: Increased circulating interleukin 4 concentration\ndefinition : An increased concentration of interleukin-4 in the blood circulation.\nsynonyms :IL-4 high in blood\n'}


{'id': 'HP_0034491', 'url': 'http://purl.obolibrary.org/obo/HP_0034491', 'lbl': 'Increased circulating interleukin 5 concentration', 'desc': 'label: Increased circulating interleukin 5 concentration\ndefinition : An increased concentration of interleukin-5 in the blood circulation.\nsynonyms :IL-5 high in blood\n'}