{'id': 'HP_0033436', 'url': 'http://purl.obolibrary.org/obo/HP_0033436', 'lbl': 'Elevated circulating 3-methyl-2-oxovaleric acid concentration', 'desc': 'label: Elevated circulating 3-methyl-2-oxovaleric acid concentration\ndefinition : An abnormally increased concentration of 3-methyl-2-oxovaleric acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033437', 'url': 'http://purl.obolibrary.org/obo/HP_0033437', 'lbl': 'Elevated circulating 4-methyl-2-oxopentanoic acid concentration', 'desc': 'label: Elevated circulating 4-methyl-2-oxopentanoic acid concentration\ndefinition : Abnormal increase of the concentration of 4-methyl-2-oxopentanoic acid in the blood circulation.\nsynonyms :Increased circulating alpha-ketoisocaproic acid concentration\n'}


{'id': 'HP_0033438', 'url': 'http://purl.obolibrary.org/obo/HP_0033438', 'lbl': 'Elevated circulating myoglobin concentration', 'desc': 'label: Elevated circulating myoglobin concentration\ndefinition : An increased blood concentration of myoglobin.\nsynonyms :\n'}


{'id': 'HP_0033439', 'url': 'http://purl.obolibrary.org/obo/HP_0033439', 'lbl': 'Elevated circulating decenoylcarnitine concentration', 'desc': 'label: Elevated circulating decenoylcarnitine concentration\ndefinition : Increased concentration of decenoylcarnitine in the blood circulation.\nsynonyms :Elevated circulating O-decenoylcarnitine concentration; Elevated plasma decenoylcarnitine, C10:1\n'}


{'id': 'HP_0033440', 'url': 'http://purl.obolibrary.org/obo/HP_0033440', 'lbl': 'Elevated circulating octenoylcarnitine concentration', 'desc': 'label: Elevated circulating octenoylcarnitine concentration\ndefinition : Increased concentration of octenoylcarnitine in the blood circulation.\nsynonyms :Elevated circulating O-octenoylcarnitine concentration; Elevated plasma octenoylcarnitine, C8:1\n'}


{'id': 'HP_0033441', 'url': 'http://purl.obolibrary.org/obo/HP_0033441', 'lbl': 'Elevated circulating hexanoylcarnitine concentration', 'desc': 'label: Elevated circulating hexanoylcarnitine concentration\ndefinition : Increased concentration of hexanoylcarnitine in the blood circulation.\nsynonyms :Elevated circulating O-hexanoylcarnitine concentration; Elevated plasma hexanoylcarnitine, C6:0\n'}


{'id': 'HP_0033442', 'url': 'http://purl.obolibrary.org/obo/HP_0033442', 'lbl': 'Elevated circulating glutarylcarnitine concentration', 'desc': 'label: Elevated circulating glutarylcarnitine concentration\ndefinition : Increased concentration of glutarylcarnitine in the blood circulation.\nsynonyms :Elevated circulating O-glutarylcarnitine concentration; Elevated plasma glutarylcarnitine, C5-DC\n'}


{'id': 'HP_0033443', 'url': 'http://purl.obolibrary.org/obo/HP_0033443', 'lbl': 'Elevated circulating propionylcarnitine concentration', 'desc': 'label: Elevated circulating propionylcarnitine concentration\ndefinition : Increased concentration of propionylcarnitine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033444', 'url': 'http://purl.obolibrary.org/obo/HP_0033444', 'lbl': 'Elevated circulating dodecanoylcarnitine concentration', 'desc': 'label: Elevated circulating dodecanoylcarnitine concentration\ndefinition : Increased concentration of dodecanoylcarnitine in the blood circulation.\nsynonyms :Elevated circulating O-dodecanoylcarnitine concentration; Elevated plasma dodecanoylcarnitine, C12:0\n'}


{'id': 'HP_0033445', 'url': 'http://purl.obolibrary.org/obo/HP_0033445', 'lbl': 'Reduced circulating acylcarnitine concentration', 'desc': 'label: Reduced circulating acylcarnitine concentration\ndefinition : An abnormally reduced concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine.\nsynonyms :\n'}


{'id': 'HP_0033446', 'url': 'http://purl.obolibrary.org/obo/HP_0033446', 'lbl': 'Elevated circulating butyrylcarnitine concentration', 'desc': 'label: Elevated circulating butyrylcarnitine concentration\ndefinition : Increased concentration of O-butyrylcarnitine in the blood circulation.\nsynonyms :Elevated circulating O-butyrylcarnitine concentration\n'}


{'id': 'HP_0033447', 'url': 'http://purl.obolibrary.org/obo/HP_0033447', 'lbl': 'Elevated circulating isovalerylcarnitine concentration', 'desc': 'label: Elevated circulating isovalerylcarnitine concentration\ndefinition : Increased concentration of O-isovalerylcarnitine in the blood circulation.\nsynonyms :Elevated circulating O-isovalerylcarnitine concentration\n'}


{'id': 'HP_0033448', 'url': 'http://purl.obolibrary.org/obo/HP_0033448', 'lbl': 'Increased mid-arm muscle circumference', 'desc': 'label: Increased mid-arm muscle circumference\ndefinition : Elevation of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children.\nsynonyms :\n'}


{'id': 'HP_0033449', 'url': 'http://purl.obolibrary.org/obo/HP_0033449', 'lbl': 'Decreased mid-arm muscle circumference', 'desc': 'label: Decreased mid-arm muscle circumference\ndefinition : Reduction of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children.\nsynonyms :\n'}


{'id': 'HP_0033450', 'url': 'http://purl.obolibrary.org/obo/HP_0033450', 'lbl': 'Abnormal circulating prealbumin concentration', 'desc': 'label: Abnormal circulating prealbumin concentration\ndefinition : Any deviation from normal concentration of albumin in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033451', 'url': 'http://purl.obolibrary.org/obo/HP_0033451', 'lbl': 'Increased circulating prealbumin concentration', 'desc': 'label: Increased circulating prealbumin concentration\ndefinition : An elevation above the normal concentration of prealbumin in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033452', 'url': 'http://purl.obolibrary.org/obo/HP_0033452', 'lbl': 'Decreased circulating prealbumin concentration', 'desc': 'label: Decreased circulating prealbumin concentration\ndefinition : A reduction from the normal concentration of prealbumin in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033453', 'url': 'http://purl.obolibrary.org/obo/HP_0033453', 'lbl': 'Limited neck extension', 'desc': 'label: Limited neck extension\ndefinition : Reduced abilty to move the head back towards the ceiling so that one is looking upwards.\nsynonyms :\n'}


{'id': 'HP_0033454', 'url': 'http://purl.obolibrary.org/obo/HP_0033454', 'lbl': 'Tube feeding', 'desc': 'label: Tube feeding\ndefinition : Feeding problem necessitating food and nutrient delivery via a tube.\nsynonyms :\n'}


{'id': 'HP_0033455', 'url': 'http://purl.obolibrary.org/obo/HP_0033455', 'lbl': 'obsolete Elevated urinary dicarboxylic acid level', 'desc': 'label: obsolete Elevated urinary dicarboxylic acid level\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033456', 'url': 'http://purl.obolibrary.org/obo/HP_0033456', 'lbl': 'Elevated urine keto acid level', 'desc': 'label: Elevated urine keto acid level\ndefinition : Increased amount of a keta acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033457', 'url': 'http://purl.obolibrary.org/obo/HP_0033457', 'lbl': 'Elevated urine 3-methyl-2-oxovaleric acid level', 'desc': 'label: Elevated urine 3-methyl-2-oxovaleric acid level\ndefinition : Increased amount of 3-methyl-2-oxovaleric acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033458', 'url': 'http://purl.obolibrary.org/obo/HP_0033458', 'lbl': 'Elevated urine 4-methyl-2-oxopentanoic acid level', 'desc': 'label: Elevated urine 4-methyl-2-oxopentanoic acid level\ndefinition : Increased amount of 4-methyl-2-oxopentanoic acid in the urine.\nsynonyms :Increased urine alpha-ketoisocaproic acid level\n'}


{'id': 'HP_0033459', 'url': 'http://purl.obolibrary.org/obo/HP_0033459', 'lbl': 'Decreased circulating apolipoprotein concentration', 'desc': 'label: Decreased circulating apolipoprotein concentration\ndefinition : Reduced concentration in the blood circulation of a lipid-transport protein (apoliprotein).\nsynonyms :Decreased apolipoprotein level\n'}


{'id': 'HP_0033460', 'url': 'http://purl.obolibrary.org/obo/HP_0033460', 'lbl': 'Increased circulating apolipoprotein circulation', 'desc': 'label: Increased circulating apolipoprotein circulation\ndefinition : Elevated concentration in the blood circulation of a lipid-transport protein (apoliprotein).\nsynonyms :\n'}


{'id': 'HP_0033461', 'url': 'http://purl.obolibrary.org/obo/HP_0033461', 'lbl': 'Elevated circulating 3-hydroxylinoleylcarnitine concentration', 'desc': 'label: Elevated circulating 3-hydroxylinoleylcarnitine concentration\ndefinition : Increased concentration of 3-hydroxylinoleylcarnitine in the blood circulation.\nsynonyms :Elevated plasma 3-OH-Linoleylcarnitine, C18:1-OH\n'}


{'id': 'HP_0033462', 'url': 'http://purl.obolibrary.org/obo/HP_0033462', 'lbl': 'Elevated circulating oleylcarnitine concentration', 'desc': 'label: Elevated circulating oleylcarnitine concentration\ndefinition : Increased concentration of oleylcarnitine in the blood circulation.\nsynonyms :Elevated plasma oleylcarnitine, C18:1\n'}


{'id': 'HP_0033463', 'url': 'http://purl.obolibrary.org/obo/HP_0033463', 'lbl': 'obsolete Elevated circulating palmitoleylcarnitine concentration', 'desc': 'label: obsolete Elevated circulating palmitoleylcarnitine concentration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033464', 'url': 'http://purl.obolibrary.org/obo/HP_0033464', 'lbl': 'Elevated circulating 3-hydroxypalmitoleylcarnitine concentration', 'desc': 'label: Elevated circulating 3-hydroxypalmitoleylcarnitine concentration\ndefinition : Increased concentration of 3-hydroxypalmitoleylcarnitine in the blood circulation.\nsynonyms :Elevated circulating 3-OH-palmitoleylcarnitine concentration; Elevated plasma 3-OH-Palmitoleylcarnitine, C16:1-OH\n'}


{'id': 'HP_0033465', 'url': 'http://purl.obolibrary.org/obo/HP_0033465', 'lbl': 'Elevated circulating tetradecanoylcarnitine concentration', 'desc': 'label: Elevated circulating tetradecanoylcarnitine concentration\ndefinition : Elevated circulating tetradecanoyl concentration.\nsynonyms :Elevated circulating C14 carnitine concentration; Elevated circulating myristoylcarnitine concentration\n'}


{'id': 'HP_0033466', 'url': 'http://purl.obolibrary.org/obo/HP_0033466', 'lbl': 'Weak grip', 'desc': 'label: Weak grip\ndefinition : Reduced grip strength. Gripping is the motion by which the hand tightly grasps an object or other hand.\nsynonyms :\n'}


{'id': 'HP_0033467', 'url': 'http://purl.obolibrary.org/obo/HP_0033467', 'lbl': 'Low 10-minute APGAR score', 'desc': "label: Low 10-minute APGAR score\ndefinition : A normal APGAR score can be coded as 'not Low 10-minute APGAR score'.\nsynonyms :\n"}


{'id': 'HP_0033468', 'url': 'http://purl.obolibrary.org/obo/HP_0033468', 'lbl': '10-minute APGAR score of 0', 'desc': 'label: 10-minute APGAR score of 0\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033469', 'url': 'http://purl.obolibrary.org/obo/HP_0033469', 'lbl': '10-minute APGAR score of 1', 'desc': 'label: 10-minute APGAR score of 1\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033470', 'url': 'http://purl.obolibrary.org/obo/HP_0033470', 'lbl': '10-minute APGAR score of 2', 'desc': 'label: 10-minute APGAR score of 2\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033471', 'url': 'http://purl.obolibrary.org/obo/HP_0033471', 'lbl': '10-minute APGAR score of 3', 'desc': 'label: 10-minute APGAR score of 3\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033472', 'url': 'http://purl.obolibrary.org/obo/HP_0033472', 'lbl': '10-minute APGAR score of 4', 'desc': 'label: 10-minute APGAR score of 4\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033473', 'url': 'http://purl.obolibrary.org/obo/HP_0033473', 'lbl': '10-minute APGAR score of 5', 'desc': 'label: 10-minute APGAR score of 5\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033474', 'url': 'http://purl.obolibrary.org/obo/HP_0033474', 'lbl': '10-minute APGAR score of 6', 'desc': 'label: 10-minute APGAR score of 6\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033475', 'url': 'http://purl.obolibrary.org/obo/HP_0033475', 'lbl': 'Limited shoulder abduction', 'desc': 'label: Limited shoulder abduction\ndefinition : Decreased ability to move the arm away from the midline of the body.\nsynonyms :\n'}


{'id': 'HP_0033476', 'url': 'http://purl.obolibrary.org/obo/HP_0033476', 'lbl': 'Extractable nuclear antigen positivity', 'desc': 'label: Extractable nuclear antigen positivity\ndefinition : The presence of autoantibodies in the serum that react against extractable nuclear components that are referred to as extractable because they can be extracted from cell nuclei with saline solution.\nsynonyms :\n'}


{'id': 'HP_0033477', 'url': 'http://purl.obolibrary.org/obo/HP_0033477', 'lbl': 'Abnormal circulating lipoprotein lipase concentration', 'desc': 'label: Abnormal circulating lipoprotein lipase concentration\ndefinition : A deviation from the normal concentration of lipoprotein lipase in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033478', 'url': 'http://purl.obolibrary.org/obo/HP_0033478', 'lbl': 'Increased circulating lipoprotein lipase concentration', 'desc': 'label: Increased circulating lipoprotein lipase concentration\ndefinition : Increased concentration of lipoprotein lipase in the blood circulation.\nsynonyms :Elevated lipoprotein lipase level\n'}


{'id': 'HP_0033479', 'url': 'http://purl.obolibrary.org/obo/HP_0033479', 'lbl': 'Abnormal circulating bilirubin concentration', 'desc': 'label: Abnormal circulating bilirubin concentration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033480', 'url': 'http://purl.obolibrary.org/obo/HP_0033480', 'lbl': 'Hypobilirubinemia', 'desc': 'label: Hypobilirubinemia\ndefinition : Concentration of bilirubin in the blood circulation below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0033481', 'url': 'http://purl.obolibrary.org/obo/HP_0033481', 'lbl': 'Limited lateral neck flexion', 'desc': 'label: Limited lateral neck flexion\ndefinition : Reduced range of motion resulting in decreased ability to move the ear toward the top of the shoulder.\nsynonyms :\n'}


{'id': 'HP_0033482', 'url': 'http://purl.obolibrary.org/obo/HP_0033482', 'lbl': 'Limited shoulder flexion', 'desc': 'label: Limited shoulder flexion\ndefinition : A reduced ability to flex the shoulder. Shoulder flexion is the motion that moves the arms from a resting position by the side of the body to a position above the head.\nsynonyms :\n'}


{'id': 'HP_0033483', 'url': 'http://purl.obolibrary.org/obo/HP_0033483', 'lbl': 'Podocyte infolding', 'desc': 'label: Podocyte infolding\ndefinition : Folding of cytoplasmic processes of podocytes into the glomerular basement membrane (GBM) with thickening of the lamina densa and microspheres and/or microtubular structures within the GBM.\nsynonyms :\n'}


{'id': 'HP_0033484', 'url': 'http://purl.obolibrary.org/obo/HP_0033484', 'lbl': 'Elevated circulating linoleylcarnitine concentration', 'desc': 'label: Elevated circulating linoleylcarnitine concentration\ndefinition : Increased concentration of linoleylcarnitine in the blood circulation.\nsynonyms :Elevated plasma linoleylcarnitine, C18:2\n'}


{'id': 'HP_0033485', 'url': 'http://purl.obolibrary.org/obo/HP_0033485', 'lbl': 'Glomerular basement membrane disruption', 'desc': 'label: Glomerular basement membrane disruption\ndefinition : A point of rupture in the glomerular basement membrane (GBM) where the discontinuous portions of GBM are still identifiable with a basement membrane stain such as Periodic acid Schiff (PAS) or silver.\nsynonyms :Disruption of the glomerular basement membrane; Glomerular basement membrane rupture\n'}


{'id': 'HP_0033486', 'url': 'http://purl.obolibrary.org/obo/HP_0033486', 'lbl': 'Abnormal glomerular basement membrane texture', 'desc': 'label: Abnormal glomerular basement membrane texture\ndefinition : Anomalous appearance or structure of the surface of the glomerular basement membrane.\nsynonyms :\n'}


{'id': 'HP_0033487', 'url': 'http://purl.obolibrary.org/obo/HP_0033487', 'lbl': 'Glomerular basement membranes powdery deposit', 'desc': 'label: Glomerular basement membranes powdery deposit\ndefinition : Punctate electron-dense material typically in a band-like distribution along the lamina rara interna and within tubular basement membranes within the subendothelial aspect of the glomerular basement membrane.\nsynonyms :Glomerular basement membranes with powdery deposit\n'}


{'id': 'HP_0033488', 'url': 'http://purl.obolibrary.org/obo/HP_0033488', 'lbl': 'Glomerular endocapillary leukocyte hypercellularity', 'desc': 'label: Glomerular endocapillary leukocyte hypercellularity\ndefinition : Increased number of leukocytes internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries.\nsynonyms :Glomerular endocapillary hypercellularity consisting of leukocytes\n'}


{'id': 'HP_0033489', 'url': 'http://purl.obolibrary.org/obo/HP_0033489', 'lbl': 'Glomerular endocapillary neutrophil hypercellularity', 'desc': 'label: Glomerular endocapillary neutrophil hypercellularity\ndefinition : Increased number of neutrophils internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries.\nsynonyms :\n'}


{'id': 'HP_0033490', 'url': 'http://purl.obolibrary.org/obo/HP_0033490', 'lbl': 'Glomerular endocapillary foam-cell hypercellularity', 'desc': 'label: Glomerular endocapillary foam-cell hypercellularity\ndefinition : Presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in the glomerulus often occupying the endocapillary space.\nsynonyms :\n'}


{'id': 'HP_0033491', 'url': 'http://purl.obolibrary.org/obo/HP_0033491', 'lbl': 'Global mesangial sclerosis', 'desc': 'label: Global mesangial sclerosis\ndefinition : A generalized global (over 80%) increase of mesangial matrix that is present throughout the mesangial stalk (with or without associated mesangial hypercellularity).\nsynonyms :\n'}


{'id': 'HP_0033492', 'url': 'http://purl.obolibrary.org/obo/HP_0033492', 'lbl': 'Podocyte cytoskeletal condensation', 'desc': 'label: Podocyte cytoskeletal condensation\ndefinition : Reorganization of podocyte cytoskeletal proteins at the glomerular basement membrane (GBM) aspect of the cell, with associated cytoplasmic electron density at the GBM aspect of the podocyte.\nsynonyms :\n'}


{'id': 'HP_0033493', 'url': 'http://purl.obolibrary.org/obo/HP_0033493', 'lbl': 'Mesangial matrix expansion', 'desc': 'label: Mesangial matrix expansion\ndefinition : Increased mesangial extracellular material with interspace width of over 2 mesangial cell nuclei, in one or more peripheral mesangial areas.\nsynonyms :Increased glomerular mesangial matrix\n'}


{'id': 'HP_0033494', 'url': 'http://purl.obolibrary.org/obo/HP_0033494', 'lbl': 'Glomerular basement membrane amyloid spicule', 'desc': 'label: Glomerular basement membrane amyloid spicule\ndefinition : Amyloid spicules are projections of typically silver-positive material from the outer aspect of the glomerular capillary wall, perpendicular to the glomerular basement membrane (GBM), most often caused by amyloidosis with the latter confirmed by additional stains.\nsynonyms :\n'}


{'id': 'HP_0033495', 'url': 'http://purl.obolibrary.org/obo/HP_0033495', 'lbl': 'Segmental glomerulosclerosis', 'desc': 'label: Segmental glomerulosclerosis\ndefinition : Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration and can include hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman capsule.\nsynonyms :\n'}


{'id': 'HP_0033496', 'url': 'http://purl.obolibrary.org/obo/HP_0033496', 'lbl': 'Perihilar segmental glomerulosclerosis', 'desc': "label: Perihilar segmental glomerulosclerosis\ndefinition : Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration is present at the vascular pole, involving less than 50% of the tuft. It can be accompanied by other descriptors such as hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman's capsule.\nsynonyms :Segmental glomerulosclerosis, perihilar pattern\n"}


{'id': 'HP_0033497', 'url': 'http://purl.obolibrary.org/obo/HP_0033497', 'lbl': 'Tip variant segmental glomerulosclerosis', 'desc': 'label: Tip variant segmental glomerulosclerosis\ndefinition : Segmental solidification of the glomerular tuft characterized by an adhesion at the tip of the glomerular tuft abutting the proximal tubular taek-off can be accompanied by increased extracellular matrix, causing glomerular capillary obliteration at the glomerular tip. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed.\nsynonyms :Segmental glomerulosclerosis, tip variant\n'}


{'id': 'HP_0033498', 'url': 'http://purl.obolibrary.org/obo/HP_0033498', 'lbl': 'Segmental glomerulosclerosis away from the vascular and tubular poles', 'desc': 'label: Segmental glomerulosclerosis away from the vascular and tubular poles\ndefinition : Segmental solidification of the glomerular tuft characterized by increased extracellular matrix, causing glomerular capillary obliteration at neirhter the tubular or vascular poles. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed.\nsynonyms :\n'}


{'id': 'HP_0033499', 'url': 'http://purl.obolibrary.org/obo/HP_0033499', 'lbl': 'Glomerular basement membrane electron dense deposits', 'desc': 'label: Glomerular basement membrane electron dense deposits\ndefinition : Electron-dense deposits in the lamina densa with a ribbon or a sausage structure.\nsynonyms :\n'}


{'id': 'HP_0033500', 'url': 'http://purl.obolibrary.org/obo/HP_0033500', 'lbl': 'Subendothelial glomerular basement membrane electron dense deposits', 'desc': 'label: Subendothelial glomerular basement membrane electron dense deposits\ndefinition : Electron dense deposits in the glomerular basement membrane (GBM) subendothelial space associated with a prominent GBM reflecting an increase in thickness. This feature can be associated with GBM remodeling along the endothelial aspect.\nsynonyms :\n'}


{'id': 'HP_0033501', 'url': 'http://purl.obolibrary.org/obo/HP_0033501', 'lbl': 'Subepithelial glomerular basement membrane electron dense deposits', 'desc': 'label: Subepithelial glomerular basement membrane electron dense deposits\ndefinition : Prominent glomerular basement membrane (GBM) reflecting a diffuse and relativly uniform increase in thickness (subjective estimate) with exogenous material deposited between the outer (epithelial) aspect of the GBM and the visceral epithelial cell, with varying degrees of incorporation into the GBM.\nsynonyms :\n'}


{'id': 'HP_0033502', 'url': 'http://purl.obolibrary.org/obo/HP_0033502', 'lbl': 'Abnormal esterified to free carnitine ratio', 'desc': 'label: Abnormal esterified to free carnitine ratio\ndefinition : Any deviation from the normal ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.\nsynonyms :\n'}


{'id': 'HP_0033503', 'url': 'http://purl.obolibrary.org/obo/HP_0033503', 'lbl': 'Elevated CSF fumarate concentration', 'desc': 'label: Elevated CSF fumarate concentration\ndefinition : An increased concentration of fumarate, an intermediate in the citric acid cycle, in the cebrebrospinal fluid.\nsynonyms :\n'}


{'id': 'HP_0033504', 'url': 'http://purl.obolibrary.org/obo/HP_0033504', 'lbl': 'Elevated circulating fumarate concentration', 'desc': 'label: Elevated circulating fumarate concentration\ndefinition : An increased concentration of fumarate, an intermediate in the citric acid cycle, in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033505', 'url': 'http://purl.obolibrary.org/obo/HP_0033505', 'lbl': 'Livedo reticularis', 'desc': 'label: Livedo reticularis\ndefinition : Livedo reticularis is characterized by the presence of a bluish purple, mottled or netlike pattern in unbroken circles on the skin. Exposure to cold environments usually intensifies the vascular pattern. Presumably, the condition results from slow or stagnant blood flow, vessel-wall pathology, and decreased oxygen tension.\nsynonyms :\n'}


{'id': 'HP_0033506', 'url': 'http://purl.obolibrary.org/obo/HP_0033506', 'lbl': 'Increased esterified to free carnitine ratio', 'desc': 'label: Increased esterified to free carnitine ratio\ndefinition : An elevated ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.\nsynonyms :\n'}


{'id': 'HP_0033507', 'url': 'http://purl.obolibrary.org/obo/HP_0033507', 'lbl': 'Decreased esterified to free carnitine ratio', 'desc': 'label: Decreased esterified to free carnitine ratio\ndefinition : A reduced ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.\nsynonyms :\n'}


{'id': 'HP_0033508', 'url': 'http://purl.obolibrary.org/obo/HP_0033508', 'lbl': 'EBV meningitis', 'desc': 'label: EBV meningitis\ndefinition : Inflammation of the meninges related to infection by Epstein-Barr virus.\nsynonyms :Epstein-Barr virus meningitis\n'}


{'id': 'HP_0033509', 'url': 'http://purl.obolibrary.org/obo/HP_0033509', 'lbl': 'EBV encephalitis', 'desc': 'label: EBV encephalitis\ndefinition : Inflamation of the brain related to infection by Epstein-Barr virus.\nsynonyms :Epstein-Barr virus encephalitis\n'}


{'id': 'HP_0033510', 'url': 'http://purl.obolibrary.org/obo/HP_0033510', 'lbl': 'Cutaneous horn', 'desc': 'label: Cutaneous horn\ndefinition : A cutaneous horn is a keratinized non-malignant protrusion on the surface of the skin. Diagnosis is established by biopsy of the horn and biopsy of the horn and the underlying skin.\nsynonyms :Cornu cutaneum\n'}


{'id': 'HP_0033511', 'url': 'http://purl.obolibrary.org/obo/HP_0033511', 'lbl': 'Drug addiction', 'desc': 'label: Drug addiction\ndefinition : Chronic compulsive drug seeking and continued use despite harmful consequences.\nsynonyms :\n'}


{'id': 'HP_0033512', 'url': 'http://purl.obolibrary.org/obo/HP_0033512', 'lbl': 'Stimulant addiction', 'desc': 'label: Stimulant addiction\ndefinition : Addiction to a stimulant drug, defined as a drug that typically increases alertness, attention and energy while also elevating blood pressure, heart rate and breathing.\nsynonyms :Stimulant dependence\n'}


{'id': 'HP_0033513', 'url': 'http://purl.obolibrary.org/obo/HP_0033513', 'lbl': 'Cocaine addiction', 'desc': 'label: Cocaine addiction\ndefinition : Addiction to cocaine.\nsynonyms :Cocaine dependence\n'}


{'id': 'HP_0033514', 'url': 'http://purl.obolibrary.org/obo/HP_0033514', 'lbl': 'Amphetamine addiction', 'desc': 'label: Amphetamine addiction\ndefinition : Addiction to amphetamine or dextroamphetamine.\nsynonyms :Amphetamine dependence; Dextroamphetamine addiction; Dextroamphetamine dependence\n'}


{'id': 'HP_0033515', 'url': 'http://purl.obolibrary.org/obo/HP_0033515', 'lbl': 'Opioid addiction', 'desc': 'label: Opioid addiction\ndefinition : Addiction to opioids.\nsynonyms :Opioid dependence\n'}


{'id': 'HP_0033516', 'url': 'http://purl.obolibrary.org/obo/HP_0033516', 'lbl': 'Benzodiazepine addiction', 'desc': 'label: Benzodiazepine addiction\ndefinition : Addiction to a benzodiazepine.\nsynonyms :Benzodiazepine dependence\n'}


{'id': 'HP_0033517', 'url': 'http://purl.obolibrary.org/obo/HP_0033517', 'lbl': 'Heroin addiction', 'desc': 'label: Heroin addiction\ndefinition : Addiction to heroin.\nsynonyms :Heroin dependence\n'}


{'id': 'HP_0033518', 'url': 'http://purl.obolibrary.org/obo/HP_0033518', 'lbl': 'Methylphenidate addiction', 'desc': 'label: Methylphenidate addiction\ndefinition : Addiction to methylphenidate.\nsynonyms :Methylphenidate dependence\n'}


{'id': 'HP_0033519', 'url': 'http://purl.obolibrary.org/obo/HP_0033519', 'lbl': 'Methamphetamine addiction', 'desc': 'label: Methamphetamine addiction\ndefinition : Addiction to methamphetamine.\nsynonyms :Methamphetamine dependence\n'}


{'id': 'HP_0033520', 'url': 'http://purl.obolibrary.org/obo/HP_0033520', 'lbl': 'Paradoxical embolism', 'desc': 'label: Paradoxical embolism\ndefinition : Paradoxical embolism describes the passage of a venous or right-sided cardiac thrombus into the arterial or systemic circulation.\nsynonyms :\n'}


{'id': 'HP_0033521', 'url': 'http://purl.obolibrary.org/obo/HP_0033521', 'lbl': 'Nasal dryness', 'desc': 'label: Nasal dryness\ndefinition : A lack of humidification of the nasal mucosa.\nsynonyms :\n'}


{'id': 'HP_0033522', 'url': 'http://purl.obolibrary.org/obo/HP_0033522', 'lbl': 'Cerebral cavernous malformation', 'desc': 'label: Cerebral cavernous malformation\ndefinition : A cerebral cavernous malformation (also known as cavernoma, cavernous angioma, cavernous hemangioma) is a collection of structurally abnormal slow-flow capillaries predominantly in the central nervous system. These are multiple mulberry-like distended caverns of dilated thin-walled capillaries without the normal intervening brain parenchymal architecture. Often, individual cavernomas are surrounded by hemosiderin representing remote oozing due to the abnormal capillaries.\nsynonyms :\n'}


{'id': 'HP_0033523', 'url': 'http://purl.obolibrary.org/obo/HP_0033523', 'lbl': 'Abnormal sperm principal piece morphology', 'desc': 'label: Abnormal sperm principal piece morphology\ndefinition : A structural anomaly of the part of the sperm flagellum that is distal to the sperm midpiece and mitochondrial sheath and which leads into the end piece.\nsynonyms :\n'}


{'id': 'HP_0033524', 'url': 'http://purl.obolibrary.org/obo/HP_0033524', 'lbl': 'Abnormal sperm axoneme morphology', 'desc': 'label: Abnormal sperm axoneme morphology\ndefinition : Abnormal structure of the sperm axonemal structure which consists of a ring of nine microtubular doublets and a central pair of microtubules, giving the classical 9+2 microtubular arrangement. The axoneme contains a central pair of microtubules (C1 and C2) that are connected by a bridge-like structure forming the central pair complex (CPC). Each of the nine outer doublets is composed of type A and B microtubules and connected by radial spokes to the CPC.\nsynonyms :\n'}


{'id': 'HP_0033525', 'url': 'http://purl.obolibrary.org/obo/HP_0033525', 'lbl': 'Absent sperm axoneme central pair complex', 'desc': 'label: Absent sperm axoneme central pair complex\ndefinition : Absense of the central pair of microtubules in the sperm axoneme, thereby forming a 9+0 pattern instead of the normal 9+2 pattern.\nsynonyms :Absent central pair complex (9+0 pattern)\n'}


{'id': 'HP_0033526', 'url': 'http://purl.obolibrary.org/obo/HP_0033526', 'lbl': 'Limited ankle dorsiflexion', 'desc': 'label: Limited ankle dorsiflexion\ndefinition : Reduced ability to move the foot up toward the shin.\nsynonyms :Heel cord tightness; Tight heel cord\n'}


{'id': 'HP_0033527', 'url': 'http://purl.obolibrary.org/obo/HP_0033527', 'lbl': 'Decreased gonadotropin-stimulated testosterone-to-androstenedione ratio', 'desc': 'label: Decreased gonadotropin-stimulated testosterone-to-androstenedione ratio\ndefinition : A reduced amount of testosterone relative in androstenedione in the blood circulation following administration of hCG (Human Chorionic Gonadotropin).\nsynonyms :Decreased plasma testosterone-to-androstenedione ratio\n'}


{'id': 'HP_0033528', 'url': 'http://purl.obolibrary.org/obo/HP_0033528', 'lbl': 'Abnormal cardiac output', 'desc': 'label: Abnormal cardiac output\ndefinition : A deviation from normal Cardiac output, which is defined as the amount of blood pumped by the heart minute and is the mechanism whereby blood flows around the body, especially providing blood flow to the brain and other vital organs.\nsynonyms :\n'}


{'id': 'HP_0033529', 'url': 'http://purl.obolibrary.org/obo/HP_0033529', 'lbl': 'Abnormal cardiac index', 'desc': 'label: Abnormal cardiac index\ndefinition : Any deviation from the normal value of the cardiac index, defined as cardiac output divided by body surface area.\nsynonyms :\n'}


{'id': 'HP_0033530', 'url': 'http://purl.obolibrary.org/obo/HP_0033530', 'lbl': 'Increased cardiac index', 'desc': 'label: Increased cardiac index\ndefinition : An elevated cardiac index, defined as cardiac output divided by body surface area.\nsynonyms :\n'}


{'id': 'HP_0033531', 'url': 'http://purl.obolibrary.org/obo/HP_0033531', 'lbl': 'Decreased cardiac index', 'desc': 'label: Decreased cardiac index\ndefinition : A reduced cardiac index, defined as cardiac output divided by body surface area.\nsynonyms :\n'}


{'id': 'HP_0033532', 'url': 'http://purl.obolibrary.org/obo/HP_0033532', 'lbl': 'Decreased cardiac output', 'desc': 'label: Decreased cardiac output\ndefinition : A decreased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat.\nsynonyms :\n'}


{'id': 'HP_0033533', 'url': 'http://purl.obolibrary.org/obo/HP_0033533', 'lbl': 'Increased cardiac output', 'desc': 'label: Increased cardiac output\ndefinition : An increased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat.\nsynonyms :\n'}


{'id': 'HP_0033534', 'url': 'http://purl.obolibrary.org/obo/HP_0033534', 'lbl': 'Increased circulating brain natriuretic peptide concentration', 'desc': 'label: Increased circulating brain natriuretic peptide concentration\ndefinition : An increased concentration of brain natriuretic peptide in the blood circulation.\nsynonyms :Elevated circulating BNP concentration; Increased B-type natriuretic peptide; Increased ventricular natriuretic peptide\n'}


{'id': 'HP_0033535', 'url': 'http://purl.obolibrary.org/obo/HP_0033535', 'lbl': 'Reduced platelet dense granules', 'desc': 'label: Reduced platelet dense granules\ndefinition : Decreased number of platelet dense granules, a type of platelet organelle.\nsynonyms :\n'}


{'id': 'HP_0033536', 'url': 'http://purl.obolibrary.org/obo/HP_0033536', 'lbl': 'Reduced platelet alpha granules', 'desc': 'label: Reduced platelet alpha granules\ndefinition : A reduced number of platelet alpha granules.\nsynonyms :\n'}


{'id': 'HP_0033537', 'url': 'http://purl.obolibrary.org/obo/HP_0033537', 'lbl': 'Mosaic pulmonary attenuation pattern', 'desc': 'label: Mosaic pulmonary attenuation pattern\ndefinition : Mosaic attenuation refers to heterogeneous areas of differing pulmonary attenuation on CT imaging.\nsynonyms :\n'}


{'id': 'HP_0033538', 'url': 'http://purl.obolibrary.org/obo/HP_0033538', 'lbl': 'Aortic annulus calcification', 'desc': 'label: Aortic annulus calcification\ndefinition : Pathological deposition of calcium salts in the aortic annulus, a fibrous ring-like structure found at the insertion point of the basal attachments of the aortic valve leaflets within the left ventricular outflow tract.\nsynonyms :Aortic annular calcification\n'}


{'id': 'HP_0033539', 'url': 'http://purl.obolibrary.org/obo/HP_0033539', 'lbl': 'Bilateral apical pulmonary fibrosis', 'desc': 'label: Bilateral apical pulmonary fibrosis\ndefinition : A reticular pattern of linear or lineonodular densities in apical portions of both the right and left lungs seen initially on high-resolution computed tomography and in case of progression also on standard chest x-ray.\nsynonyms :\n'}


{'id': 'HP_0033540', 'url': 'http://purl.obolibrary.org/obo/HP_0033540', 'lbl': 'Reversible airflow obstruction', 'desc': 'label: Reversible airflow obstruction\ndefinition : Airflow obstruction with a significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL.\nsynonyms :Reversible pulmonary obstruction\n'}


{'id': 'HP_0033541', 'url': 'http://purl.obolibrary.org/obo/HP_0033541', 'lbl': 'Irreversible airflow obstruction', 'desc': 'label: Irreversible airflow obstruction\ndefinition : Airflow obstruction without significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL.\nsynonyms :Irreversible pulmonary obstruction\n'}


{'id': 'HP_0033542', 'url': 'http://purl.obolibrary.org/obo/HP_0033542', 'lbl': 'Bronchial wall thickening', 'desc': 'label: Bronchial wall thickening\ndefinition : Radiological appearance of increased density around the walls of a bronchus or large bronchiole. This feature is thought to be related to edema involving the bronchial wall as well as the peribronchial interstitial space. If the cross section of a bronchus is captured in a radiograph or computed tomography image, it is said to have the appearance of a donut because of the central lucency representing the airway of the bronchus surrounded by a circular region of increased density.\nsynonyms :Peribronchial cuffing; Peribronchial thickening\n'}


{'id': 'HP_0033543', 'url': 'http://purl.obolibrary.org/obo/HP_0033543', 'lbl': 'Nicotine addiction', 'desc': 'label: Nicotine addiction\ndefinition : Nicotine addition can be defined as chronic compulsive nicotine seeking and continued use despite harmful consequences.\nsynonyms :Nicotine dependence\n'}


{'id': 'HP_0033544', 'url': 'http://purl.obolibrary.org/obo/HP_0033544', 'lbl': 'Mesangial fibril deposition', 'desc': 'label: Mesangial fibril deposition\ndefinition : Extracellular mesangial accumulation of slender proteinaceous fibers.\nsynonyms :\n'}


{'id': 'HP_0033545', 'url': 'http://purl.obolibrary.org/obo/HP_0033545', 'lbl': 'Mesangial fibrillary deposits', 'desc': 'label: Mesangial fibrillary deposits\ndefinition : Extracellular mesangial aggregates composed of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material.\nsynonyms :\n'}


{'id': 'HP_0033546', 'url': 'http://purl.obolibrary.org/obo/HP_0033546', 'lbl': 'Mesangial microfibril deposition', 'desc': 'label: Mesangial microfibril deposition\ndefinition : Unbranched noncollagenous microfibrils within the mesangial matrix, composed of proteins not present within the glomerular basement membrane (GBM), most notably fibrillin-1, that attach to mesangial cells and GBM structural proteins.\nsynonyms :\n'}


{'id': 'HP_0033547', 'url': 'http://purl.obolibrary.org/obo/HP_0033547', 'lbl': 'Mesangial immunotactoid deposits', 'desc': 'label: Mesangial immunotactoid deposits\ndefinition : Extracellular mesangial aggregates composed of non-branching fibrils, focally parralel over 30 nM in diameter. The term immunotactoid refers to highly organized immune depositions appearing as rod-like microtubular structures in ultrastructural examination.\nsynonyms :\n'}


{'id': 'HP_0033548', 'url': 'http://purl.obolibrary.org/obo/HP_0033548', 'lbl': 'Mesangial amyloid deposition', 'desc': 'label: Mesangial amyloid deposition\ndefinition : Extracellular mesangial aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass.\nsynonyms :\n'}


{'id': 'HP_0033549', 'url': 'http://purl.obolibrary.org/obo/HP_0033549', 'lbl': 'Nodular mesangiosclerosis', 'desc': 'label: Nodular mesangiosclerosis\ndefinition : Lobular, round to oval mesangial lesions with an acellular hyaline/matrix core surrounded by compressed mesangial nuclei.\nsynonyms :\n'}


{'id': 'HP_0033550', 'url': 'http://purl.obolibrary.org/obo/HP_0033550', 'lbl': 'Necrotizing pulmonary granulomatosis', 'desc': 'label: Necrotizing pulmonary granulomatosis\ndefinition : A granuloma that is associated with necrotic changes. Caseation necrosis is defined as a region in granulomas with eosinophilic, granular and cheese-like cellular debris with necrosis. The word caseous itself means pertaining or related to cheese, and comes from the Latin word caseus, meaning cheese.\nsynonyms :Caseating pulmonary granulomatosis\n'}


{'id': 'HP_0033551', 'url': 'http://purl.obolibrary.org/obo/HP_0033551', 'lbl': 'Non-necrotizing pulmonary granulomatosis', 'desc': 'label: Non-necrotizing pulmonary granulomatosis\ndefinition : A granuloma located in the lung that is not associated with necrotic changes.\nsynonyms :Non-caseating pulmonary granulomatosis\n'}


{'id': 'HP_0033552', 'url': 'http://purl.obolibrary.org/obo/HP_0033552', 'lbl': 'Chronic villitis', 'desc': 'label: Chronic villitis\ndefinition : Villitis of unknown etiology (synonymous with villitis of unknown aetiology) is a histologic diagnosis and, although it may have a variable distribution, evidence indicates that 3 parenchymal blocks will identify 62% of villitis, reaching an asymptote of 6 and 7 blocks identifying 85% of villitis. Villitis of unknown etiology by definition excludes those cases where an etiology is identified, such as viral or acute infections, and thus is preferred to the term nonspecific chronic villitis. It is usually lymphohistiocytic: although the presence of rare plasma cells does not exclude the diagnosis, thorough evaluation for an infectious etiology, such as cytomegalovirus, is required in a predominantly plasma cell villitis.\nsynonyms :Chronic villitis (non-infectious); Nonspecific chronic villitis; Villitis of unknown aetiology; Villitis of unknown etiology\n'}


{'id': 'HP_0033553', 'url': 'http://purl.obolibrary.org/obo/HP_0033553', 'lbl': 'Septic embolism', 'desc': 'label: Septic embolism\ndefinition : Embolization of intravascular thrombus containing microorganisms into the distant tissues via arterial system.\nsynonyms :Septic emboli\n'}


{'id': 'HP_0033554', 'url': 'http://purl.obolibrary.org/obo/HP_0033554', 'lbl': 'Anti-Mi2 antibody positivity', 'desc': 'label: Anti-Mi2 antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against the Mi-2 antigen.\nsynonyms :\n'}


{'id': 'HP_0033555', 'url': 'http://purl.obolibrary.org/obo/HP_0033555', 'lbl': 'Anti-Ro/SS-A antibody positivity', 'desc': 'label: Anti-Ro/SS-A antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against Ro/SSA autoantigens.\nsynonyms :Anti-Ro/SSA antibody positivity\n'}


{'id': 'HP_0033556', 'url': 'http://purl.obolibrary.org/obo/HP_0033556', 'lbl': 'Anti-nucleoporin 62 antibody positivity', 'desc': 'label: Anti-nucleoporin 62 antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react against nucleoporin 62.\nsynonyms :Anti-p62 antibody positivity\n'}


{'id': 'HP_0033557', 'url': 'http://purl.obolibrary.org/obo/HP_0033557', 'lbl': 'Anti-proteinase 3 antibody positivity', 'desc': 'label: Anti-proteinase 3 antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against proteinase 3. Proteinase 3 (PR3) antigen is a 29-kD serine protease that exists as a protein triplet in human neutrophils\nsynonyms :Anti-PR3 antibody positivity\n'}


{'id': 'HP_0033558', 'url': 'http://purl.obolibrary.org/obo/HP_0033558', 'lbl': 'Anti-histone antibody positivity', 'desc': 'label: Anti-histone antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against histone antigens.\nsynonyms :\n'}


{'id': 'HP_0033559', 'url': 'http://purl.obolibrary.org/obo/HP_0033559', 'lbl': 'Anti-myeloperoxidase antibody positivity', 'desc': 'label: Anti-myeloperoxidase antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against myeloperoxidase.\nsynonyms :Anti-MPO antibody positivity\n'}


{'id': 'HP_0033560', 'url': 'http://purl.obolibrary.org/obo/HP_0033560', 'lbl': 'Anti-PM-Scl antibody positivity', 'desc': 'label: Anti-PM-Scl antibody positivity\ndefinition : Anti-PM-Scl antibodies target components of RNA-processing exosome complex in the nucleolus. There are ten proteins in this complex and antibodies to eight of them are found at varying frequencies; PM/Scl-100, PM/Scl-75, hRrp4, hRrp42, hRrp46, hCs14, hRrp41, and hRrp40.\nsynonyms :Anti-PM/Scl antibody positivity\n'}


{'id': 'HP_0033561', 'url': 'http://purl.obolibrary.org/obo/HP_0033561', 'lbl': 'Anti-bactericidal/permeability-increasing protein antibody positivity', 'desc': 'label: Anti-bactericidal/permeability-increasing protein antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against bactericidal/permeability-increasing protein (BPI). BPI is an endotoxin-binding host protein with important antibacterial effects against Gram-negative bacteria, such as Pseudomonas aeruginosa. \nBPI is a 55 kDalton protein that is most abundant in the azurophilic granules of neutrophils. BPI also acts as a target antigen for antineutrophil cytoplasmic autoantibodies.\nsynonyms :Anti-BPI antibody positivity\n'}


{'id': 'HP_0033562', 'url': 'http://purl.obolibrary.org/obo/HP_0033562', 'lbl': 'Anti-glycoprotein-210 antibody positivity', 'desc': 'label: Anti-glycoprotein-210 antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react against glycoprotein-210.\nsynonyms :Anti-gp210 antibody positivity\n'}


{'id': 'HP_0033563', 'url': 'http://purl.obolibrary.org/obo/HP_0033563', 'lbl': 'Anti-tissue transglutaminase antibody positivity', 'desc': 'label: Anti-tissue transglutaminase antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react against tissue transglutaminase.\nsynonyms :Anti-tTG antibody positivity\n'}


{'id': 'HP_0033564', 'url': 'http://purl.obolibrary.org/obo/HP_0033564', 'lbl': 'Stasis dermatitis', 'desc': 'label: Stasis dermatitis\ndefinition : Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Stasis dermatitis presents initially as poorly demarcated erythematous plaques of the lower legs bilaterally, classically involving the medial malleolus.\nsynonyms :Varicose eczema; Venous eczema\n'}


{'id': 'HP_0033565', 'url': 'http://purl.obolibrary.org/obo/HP_0033565', 'lbl': 'Anti-epidermal transglutaminase antibody positivity', 'desc': 'label: Anti-epidermal transglutaminase antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the blood circulation that react against epidermal transglutaminase.\nsynonyms :Anti-TG3 antibody; Anti-eTG antibody positivity; Anti-epidermal transglutaminase (anti-eTG) antibody; Anti-keratinocyte transglutaminase\n'}


{'id': 'HP_0033566', 'url': 'http://purl.obolibrary.org/obo/HP_0033566', 'lbl': 'Abnormal ventricular axis', 'desc': 'label: Abnormal ventricular axis\ndefinition : Any deviation from the normal direction of the ventricular axis. The left ventricle makes up most of the heart muscle under normal circumstances and therefore generates the most electrical force visible on the EKG. The normal ventricular axis is directed downward and slightly towards the left. The ventricular axis can be determined by analyzing the QRS complex, which represents ventricular depolarization.\nsynonyms :Abnormal QRS axis\n'}


{'id': 'HP_0033567', 'url': 'http://purl.obolibrary.org/obo/HP_0033567', 'lbl': 'Right axis deviation', 'desc': 'label: Right axis deviation\ndefinition : A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between +90 degrees and 180 degrees, or beyond +100 degrees if the adult range is used.\nsynonyms :Electrical right axis deviation; RAD\n'}


{'id': 'HP_0033568', 'url': 'http://purl.obolibrary.org/obo/HP_0033568', 'lbl': 'Left axis deviation', 'desc': 'label: Left axis deviation\ndefinition : A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between -30 degrees and -90 degrees.\nsynonyms :Electrical left axis deviation\n'}


{'id': 'HP_0033569', 'url': 'http://purl.obolibrary.org/obo/HP_0033569', 'lbl': 'Extreme axis deviation', 'desc': 'label: Extreme axis deviation\ndefinition : A kind of abnormal ventricular axis in the EKG whereby the QRS axis fall sbetween -90 degrees and 180 degrees. In this case, the ventricular vector is directed upward and to the right.\nsynonyms :\n'}


{'id': 'HP_0033570', 'url': 'http://purl.obolibrary.org/obo/HP_0033570', 'lbl': 'Indeterminate ventricular axis', 'desc': 'label: Indeterminate ventricular axis\ndefinition : A kind of abnormal ventricular axis in the EKG whereby the QRS complex is isoelectric or equiphasic in all leads with no dominant QRS deflection.\nsynonyms :\n'}


{'id': 'HP_0033571', 'url': 'http://purl.obolibrary.org/obo/HP_0033571', 'lbl': 'Peripheral lung neovascularity', 'desc': 'label: Peripheral lung neovascularity\ndefinition : The presence of small, tortuous, micronodular, serpiginous intrapulmonary vessels often in the subpleural lung or in proximity to centrilobular arterioles, coursing in directions inconsistent with known arteriolar anatomy.\nsynonyms :\n'}


{'id': 'HP_0033572', 'url': 'http://purl.obolibrary.org/obo/HP_0033572', 'lbl': 'Anti-H1 antibody positivity', 'desc': 'label: Anti-H1 antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against histone H1.\nsynonyms :\n'}


{'id': 'HP_0033573', 'url': 'http://purl.obolibrary.org/obo/HP_0033573', 'lbl': 'Anti-H4 antibody positivity', 'desc': 'label: Anti-H4 antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against histone H4.\nsynonyms :\n'}


{'id': 'HP_0033574', 'url': 'http://purl.obolibrary.org/obo/HP_0033574', 'lbl': 'Anti-H3 antibody positivity', 'desc': 'label: Anti-H3 antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against histone H3.\nsynonyms :\n'}


{'id': 'HP_0033575', 'url': 'http://purl.obolibrary.org/obo/HP_0033575', 'lbl': 'Anti-H2A antibody positivity', 'desc': 'label: Anti-H2A antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against histone H2A.\nsynonyms :\n'}


{'id': 'HP_0033576', 'url': 'http://purl.obolibrary.org/obo/HP_0033576', 'lbl': 'Anti-H2B antibody positivity', 'desc': 'label: Anti-H2B antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against histone H2B.\nsynonyms :\n'}


{'id': 'HP_0033577', 'url': 'http://purl.obolibrary.org/obo/HP_0033577', 'lbl': 'In situ pulmonary artery thrombosis', 'desc': 'label: In situ pulmonary artery thrombosis\ndefinition : Localized thrombosis in pulmonary arteries frequently found in patients with idiopathic and hereditary pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease.\nsynonyms :\n'}


{'id': 'HP_0033578', 'url': 'http://purl.obolibrary.org/obo/HP_0033578', 'lbl': 'Pre-capillary pulmonary hypertension', 'desc': 'label: Pre-capillary pulmonary hypertension\ndefinition : Pre-capillary pulmonary hypertension is a haemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary vascular resistance (PVR 3 Wood units or more) accompanied by normal pulmonary artery wedge pressure (PAWP not more than 15 mmHg).\nsynonyms :Precapillary pulmonary hypertension\n'}


{'id': 'HP_0033579', 'url': 'http://purl.obolibrary.org/obo/HP_0033579', 'lbl': 'Decreased growth hormone responses to growth hormone-releasing hormone challenge', 'desc': 'label: Decreased growth hormone responses to growth hormone-releasing hormone challenge\ndefinition : Insufficient growth hormone secretion following administration of growth hormone-releasing hormone.\nsynonyms :Impaired growth hormone secretory responses after growth hormone-releasing hormone challenge\n'}


{'id': 'HP_0033580', 'url': 'http://purl.obolibrary.org/obo/HP_0033580', 'lbl': 'Compound motor action potential abnormality', 'desc': 'label: Compound motor action potential abnormality\ndefinition : An abnormal finding in a compound motor action potential measurement in EMG. Nerve conduction studies involve the application of a depolarising square wave electrical pulses to the skin over a peripheral nerve producing: (1) a propagated nerve action potential (NAP) recorded at a distant point over the same nerve: and (2) a compound muscle action potential (CMAP) arising from the activation of muscle fibres in a target muscle supplied by the nerve. In both cases these may be recorded with surface or needle electrodes. The CMAP is a summated voltage response from the individual muscle fibre action potentials. The shortest latency of the CMAP is the time from stimulus artefact to onset of the response and is a biphasic response with an initial upward deflection followed by a smaller downward deflection. The CMAP amplitude is measured from baseline to negative peak (the neurophysiological convention is that negative voltage is demonstrated by an upward deflection) and measured in millivolts (mV).\nsynonyms :\n'}


{'id': 'HP_0033581', 'url': 'http://purl.obolibrary.org/obo/HP_0033581', 'lbl': 'Absent peripheral lymph nodes in presence of infection', 'desc': 'label: Absent peripheral lymph nodes in presence of infection\ndefinition : The absence of any palpable lymph nodes in the presence of symptoms suggesting infection in that drainage area should raise suspicion for immunodeficiency diseases.\nsynonyms :\n'}


{'id': 'HP_0033582', 'url': 'http://purl.obolibrary.org/obo/HP_0033582', 'lbl': 'Pulmonary interstitial lymphocyte infiltration', 'desc': 'label: Pulmonary interstitial lymphocyte infiltration\ndefinition : Abnormal accumulation of lymphocytes in the interstitium of the lung.\nsynonyms :\n'}


{'id': 'HP_0033583', 'url': 'http://purl.obolibrary.org/obo/HP_0033583', 'lbl': 'Follicular bronchiolitis', 'desc': 'label: Follicular bronchiolitis\ndefinition : Follicular bronchiolitis is a polyclonal hyperplasia of bronchiolar associated lymphoid tissue characterized by the is characterized by the development of lymphoid follicles with germinal centers in walls of the small airways.\nsynonyms :\n'}


{'id': 'HP_0033584', 'url': 'http://purl.obolibrary.org/obo/HP_0033584', 'lbl': 'Nonspecific interstitial pneumonia', 'desc': 'label: Nonspecific interstitial pneumonia\ndefinition : Temporally uniform (all lesions are in the same stage of evolution) pattern of diffuse inflammatory interstitial process, mostly symmetric over the entire lung, involving mainly the alveolar septa.\nsynonyms :NSIP; Nonspecific interstitial pneumonitis; Temporally uniform pulmonary inflammation\n'}


{'id': 'HP_0033585', 'url': 'http://purl.obolibrary.org/obo/HP_0033585', 'lbl': 'Fibrotic non-specific interstitial pneumonia', 'desc': 'label: Fibrotic non-specific interstitial pneumonia\ndefinition : A type of non-specific interstitial pneumonia in which interstitial thickening is due to uniform dense or loose fibrosis and mild chronic inflammation.\nsynonyms :\n'}


{'id': 'HP_0033586', 'url': 'http://purl.obolibrary.org/obo/HP_0033586', 'lbl': 'Cellular non-specific interstitial pneumonia', 'desc': 'label: Cellular non-specific interstitial pneumonia\ndefinition : A type of non-specific interstitial pneumonia in which interstitial thickening is mainly due to infiltration of inflammatory cells and type II pneumocyte hyperplasia.\nsynonyms :\n'}


{'id': 'HP_0033587', 'url': 'http://purl.obolibrary.org/obo/HP_0033587', 'lbl': 'Vulvar abscess', 'desc': 'label: Vulvar abscess\ndefinition : A circumscribed area of pus or necrotic debris in the vulvar region.\nsynonyms :\n'}


{'id': 'HP_0033588', 'url': 'http://purl.obolibrary.org/obo/HP_0033588', 'lbl': 'Labial adhesion', 'desc': 'label: Labial adhesion\ndefinition : Synechia vulvae (adhesions of the labia minora) are characterized by a complete or partial fusion of the labia minora in the midline.\nsynonyms :Labial agglutination; Synechia vulvae\n'}


{'id': 'HP_0033589', 'url': 'http://purl.obolibrary.org/obo/HP_0033589', 'lbl': 'Flatulence', 'desc': 'label: Flatulence\ndefinition : Passage of excessive amounts of gas and the feeling of abdominal fullness and bloating.\nsynonyms :\n'}


{'id': 'HP_0033590', 'url': 'http://purl.obolibrary.org/obo/HP_0033590', 'lbl': 'Inguinal abscess', 'desc': 'label: Inguinal abscess\ndefinition : A circumscribed area of pus or necrotic debris in the groin (inguinal region).\nsynonyms :Groin abscess\n'}


{'id': 'HP_0033591', 'url': 'http://purl.obolibrary.org/obo/HP_0033591', 'lbl': 'Staghorn calculus', 'desc': 'label: Staghorn calculus\ndefinition : Large branching stones that fill part of all of the renal pelvis and renal calyces and they can be complete or partial depending on the level of occupancy of the collecting system.\nsynonyms :Staghorn renal stone\n'}


{'id': 'HP_0033592', 'url': 'http://purl.obolibrary.org/obo/HP_0033592', 'lbl': 'Anti-H3-H4 antibody positivity', 'desc': 'label: Anti-H3-H4 antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against the H3-H4 histone dimer.\nsynonyms :\n'}


{'id': 'HP_0033593', 'url': 'http://purl.obolibrary.org/obo/HP_0033593', 'lbl': 'Anti-H2A-H2B antibody positivity', 'desc': 'label: Anti-H2A-H2B antibody positivity\ndefinition : The presence of autoantibodies in the blood circulation that react against the H2A-H2B histone dimer.\nsynonyms :\n'}


{'id': 'HP_0033594', 'url': 'http://purl.obolibrary.org/obo/HP_0033594', 'lbl': 'Elevated urinary 7-biopterin level', 'desc': 'label: Elevated urinary 7-biopterin level\ndefinition : An abnormally increased amount of 7-biopterin in the urine.\nsynonyms :Primapterinuria\n'}


{'id': 'HP_0033595', 'url': 'http://purl.obolibrary.org/obo/HP_0033595', 'lbl': 'Elevated circulating globotriaosylceramide concentration', 'desc': 'label: Elevated circulating globotriaosylceramide concentration\ndefinition : Increased concentration of globotriaosylceramide (Gb3) in the blood circulation. Globotriaosylceramide, also named ceramidetrihexoside, is the primary lipid storage in Fabry disease.\nsynonyms :Elevated circulating ceramidetrihexoside concentration\n'}


{'id': 'HP_0033596', 'url': 'http://purl.obolibrary.org/obo/HP_0033596', 'lbl': 'Elevated urinary 3-methylcrotonylglycine level', 'desc': 'label: Elevated urinary 3-methylcrotonylglycine level\ndefinition : An abnormally increased amount of 3-methylcrotonylglycine in the urine.\nsynonyms :\n'}


{'id': 'HP_0033597', 'url': 'http://purl.obolibrary.org/obo/HP_0033597', 'lbl': 'Decreased mucosal sucrase-isomaltase activity', 'desc': 'label: Decreased mucosal sucrase-isomaltase activity\ndefinition : Reduced activity of the linked disaccharidase, sucrase-isomaltase, which is a glycoprotein localized to the brush border membrane of small intestinal villi.\nsynonyms :\n'}


{'id': 'HP_0033598', 'url': 'http://purl.obolibrary.org/obo/HP_0033598', 'lbl': 'Fibrillar glomerular subepithelial deposits', 'desc': 'label: Fibrillar glomerular subepithelial deposits\ndefinition : Fibrillar deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate).\nsynonyms :\n'}


{'id': 'HP_0033599', 'url': 'http://purl.obolibrary.org/obo/HP_0033599', 'lbl': 'Glomerular amyloid subepithelial deposits', 'desc': 'label: Glomerular amyloid subepithelial deposits\ndefinition : A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).\nsynonyms :\n'}


{'id': 'HP_0033600', 'url': 'http://purl.obolibrary.org/obo/HP_0033600', 'lbl': 'Fibrillary glomerular subepithelial deposits', 'desc': 'label: Fibrillary glomerular subepithelial deposits\ndefinition : A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).\nsynonyms :\n'}


{'id': 'HP_0033601', 'url': 'http://purl.obolibrary.org/obo/HP_0033601', 'lbl': 'Glomerular subepithelial immune-complex deposits', 'desc': 'label: Glomerular subepithelial immune-complex deposits\ndefinition : A type of glomerular subepithelial deposit characterized by finely granular material deposited between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM and corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry. This feature is associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).\nsynonyms :\n'}


{'id': 'HP_0033602', 'url': 'http://purl.obolibrary.org/obo/HP_0033602', 'lbl': 'Glomerular hyaline subepithelial deposits', 'desc': 'label: Glomerular hyaline subepithelial deposits\ndefinition : A type of glomerular subepithelial deposit characterized by a moderately electron-dense, generally homogenous, amorphous-appearing extracellular material located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).\nsynonyms :\n'}


{'id': 'HP_0033603', 'url': 'http://purl.obolibrary.org/obo/HP_0033603', 'lbl': 'Glomerular subepithelial deposits', 'desc': 'label: Glomerular subepithelial deposits\ndefinition : Deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature may be associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).\nsynonyms :\n'}


{'id': 'HP_0033604', 'url': 'http://purl.obolibrary.org/obo/HP_0033604', 'lbl': 'Glomerular capillary wire loop deposits', 'desc': 'label: Glomerular capillary wire loop deposits\ndefinition : Glomerulus showing markedly and irregularly thickened capillary walls with massive fuchsinophilic subendothelial deposits, resulting in narrowing of capillary lumina. This feature is said to resemble a wire loop.\nsynonyms :\n'}


{'id': 'HP_0033605', 'url': 'http://purl.obolibrary.org/obo/HP_0033605', 'lbl': 'Pustular rash', 'desc': 'label: Pustular rash\ndefinition : A rash composed of pustular lesions. A pustule is defined as a vesicle or bulla containing purulent material. It varies in size and may occur at different levels within the epidermis: subcorneal, intraepidermal, or basement membrane zones. The pustules may or may not be sterile and are normally filled with neutrophils.\nsynonyms :Pustulosis\n'}


{'id': 'HP_0033606', 'url': 'http://purl.obolibrary.org/obo/HP_0033606', 'lbl': 'Bone marrow maturation arrest', 'desc': 'label: Bone marrow maturation arrest\ndefinition : Interruption of the procecss of diffferentiation of hematopoietic cells in the bone marrow, manifested by an increased proportion of immature cells in the bone marrow.\nsynonyms :Haematopoietic maturation arrest; Hematopoietic maturation arrest\n'}


{'id': 'HP_0033607', 'url': 'http://purl.obolibrary.org/obo/HP_0033607', 'lbl': 'Bone marrow arrest at the promyelocytic stage', 'desc': 'label: Bone marrow arrest at the promyelocytic stage\ndefinition : A type of bone marrow maturation arrest characterized by accumulation of neutrophil precursor cells in the bone marrow.\nsynonyms :\n'}


{'id': 'HP_0033608', 'url': 'http://purl.obolibrary.org/obo/HP_0033608', 'lbl': 'Pulmonary nodule', 'desc': 'label: Pulmonary nodule\ndefinition : Focal rounded or ovoid opacity, not more than 3 cm in diameter. Pulmonary nodules are typically observed by chest radiography or computer tomography imaging.\nsynonyms :Spot on the lung\n'}


{'id': 'HP_0033609', 'url': 'http://purl.obolibrary.org/obo/HP_0033609', 'lbl': 'Solid pulmonary nodule', 'desc': 'label: Solid pulmonary nodule\ndefinition : A type of pulmonary nodule whose density obscures the underlying parenchyma and thus has a "solid" appearance.\nsynonyms :\n'}


{'id': 'HP_0033610', 'url': 'http://purl.obolibrary.org/obo/HP_0033610', 'lbl': 'Subsolid pulmonary nodule', 'desc': 'label: Subsolid pulmonary nodule\ndefinition : Pulmonary subsolid nodules (SSNs) refer to pulmonary nodules with pure ground-glass nodules and part-solid ground-glass nodules. A ground-glass nodule (GGN) is the morphologic description of a pulmonary nodule category on thin-section chest computed tomography (CT). During the past decade, the natural history, management strategy and long-term prognosis in the case of GGNs have attracted attention.\nsynonyms :\n'}


{'id': 'HP_0033611', 'url': 'http://purl.obolibrary.org/obo/HP_0033611', 'lbl': 'Part-solid pulmonary nodule', 'desc': 'label: Part-solid pulmonary nodule\ndefinition : Part-solid pulmonary nodules are nodules that present with both ground-glass and solid components in which the underlying lung architecture cannot be visualized.\nsynonyms :\n'}


{'id': 'HP_0033612', 'url': 'http://purl.obolibrary.org/obo/HP_0033612', 'lbl': 'Pure ground-glass pulmonary nodule', 'desc': 'label: Pure ground-glass pulmonary nodule\ndefinition : Pure ground-glass pulmonary nodules (GGNs) are defined as focal nodular areas of increased lung attenuation through which lung parenchymal structures, such as the pulmonary vessels or bronchial structures, can be observed.\nsynonyms :\n'}


{'id': 'HP_0033613', 'url': 'http://purl.obolibrary.org/obo/HP_0033613', 'lbl': 'Perifissural pulmonary nodule', 'desc': 'label: Perifissural pulmonary nodule\ndefinition : Solid, homogenous nodules characterised by a smooth margin and oval, rounded, lentiform or triangular shape. They are typically located within 15 mm from the issue or the pleura. Perifissural nodules may be further differentiated into typical (have contact with interlobar septum) and atypical (do not have contact with interlobar septum). They likely represent intrapulmonary lymphnodes.\nsynonyms :\n'}


{'id': 'HP_0033614', 'url': 'http://purl.obolibrary.org/obo/HP_0033614', 'lbl': 'Tracheal bronchus', 'desc': 'label: Tracheal bronchus\ndefinition : Aberrant or accessory bronchus supplying the upper lobe originating from the lateral wall of the trachea. The tracheal bronchus is more commonly right-sided, has a variable length and may be blind-ended. Two common types of tracheal bronchus are: supernumerary and displaced.\nsynonyms :\n'}


{'id': 'HP_0033615', 'url': 'http://purl.obolibrary.org/obo/HP_0033615', 'lbl': 'Displaced tracheal bronchus', 'desc': 'label: Displaced tracheal bronchus\ndefinition : Accessory bronchus originating from trachea replacing one of the segmental branches of the anatomically normal upper lobe bronchus.\nsynonyms :\n'}


{'id': 'HP_0033616', 'url': 'http://purl.obolibrary.org/obo/HP_0033616', 'lbl': 'Accessory cardiac bronchus', 'desc': 'label: Accessory cardiac bronchus\ndefinition : Accessory bronchus originating from the medial wall of the right or left ban bronchus or bronchus intermedius. A cardiac bronchus is usually blind-ended.\nsynonyms :\n'}


{'id': 'HP_0033617', 'url': 'http://purl.obolibrary.org/obo/HP_0033617', 'lbl': 'Supernumerary tracheal bronchus', 'desc': 'label: Supernumerary tracheal bronchus\ndefinition : Accessory bronchus which exits the trachea in addition to an anatomically normal branching upper lobe bronchus.\nsynonyms :\n'}


{'id': 'HP_0033618', 'url': 'http://purl.obolibrary.org/obo/HP_0033618', 'lbl': 'Displaced lobar tracheal bronchus', 'desc': 'label: Displaced lobar tracheal bronchus\ndefinition : Accessory entire right upper lobe bronchial system originating from the trachea with absent anatomically normal upper lobe bronchus.\nsynonyms :Bronchus suis; Pig bronchus\n'}


{'id': 'HP_0033619', 'url': 'http://purl.obolibrary.org/obo/HP_0033619', 'lbl': 'Typical perifissural nodule', 'desc': 'label: Typical perifissural nodule\ndefinition : A perifissural nodule that has contact with the interlobar septum (and is therefore considered typical).\nsynonyms :\n'}


{'id': 'HP_0033620', 'url': 'http://purl.obolibrary.org/obo/HP_0033620', 'lbl': 'Atypical perifissural nodule', 'desc': 'label: Atypical perifissural nodule\ndefinition : A perifissural nodule that does not have contact with the interlobar septum (and is therefore considered atypical).\nsynonyms :\n'}


{'id': 'HP_0033621', 'url': 'http://purl.obolibrary.org/obo/HP_0033621', 'lbl': 'Bronchial diverticula', 'desc': 'label: Bronchial diverticula\ndefinition : Bronchial diverticula are blind-ended outpouchings arising from the bronchial tree. They are commonly pulsion diverticula acquired related to chronic cough. Subcarinal air cyst is thought to represent a small main bronchial diverticulum.\nsynonyms :\n'}


{'id': 'HP_0033622', 'url': 'http://purl.obolibrary.org/obo/HP_0033622', 'lbl': 'Migratory erythematous plaque', 'desc': 'label: Migratory erythematous plaque\ndefinition : A migratory, centrifugal, erythematous, tender, non-purpuric, and well-demarcated plaque. This feature may be observed in TNF receptor-associated periodic syndrome, in which it often occurs together with migratory myalgia in muscles located underneath the affected areas of skin.\nsynonyms :\n'}


{'id': 'HP_0033623', 'url': 'http://purl.obolibrary.org/obo/HP_0033623', 'lbl': 'Birth history', 'desc': 'label: Birth history\ndefinition : Information about the delivery and health status at birth typically elicited as a part of the past medical history.\nsynonyms :\n'}


{'id': 'HP_0033624', 'url': 'http://purl.obolibrary.org/obo/HP_0033624', 'lbl': 'History of congenital CMV infection', 'desc': 'label: History of congenital CMV infection\ndefinition : A congenital cytomegalovirus (CMV) infection of the newborn can follow either a primary or recurrent maternal infection. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. Affected infants may develop permanent disabilities such as hearing loss, vision loss, motor and cognitive deficits.\nsynonyms :History of congenital cytomegalovirus infection\n'}


{'id': 'HP_0033625', 'url': 'http://purl.obolibrary.org/obo/HP_0033625', 'lbl': 'Emotional insecurity', 'desc': 'label: Emotional insecurity\ndefinition : A feeling of general unease or nervousness that may be triggered by a sense of vulnerability or instability which is perceived as threatening.\nsynonyms :\n'}


{'id': 'HP_0033626', 'url': 'http://purl.obolibrary.org/obo/HP_0033626', 'lbl': 'Increased non-HDL cholesterol concentration', 'desc': 'label: Increased non-HDL cholesterol concentration\ndefinition : Increase above normal levels of non-HDL cholesterol in the blood. Non-HDL cholesterol is total cholesterol minus high-density lipoprotein HDL-cholesterol (high-density lipoprotein-cholesterol).\nsynonyms :Elevated non-HDL cholesterol concentration\n'}


{'id': 'HP_0033627', 'url': 'http://purl.obolibrary.org/obo/HP_0033627', 'lbl': 'Increased urine harderoporphyrin level', 'desc': 'label: Increased urine harderoporphyrin level\ndefinition : Increased amount of harderoporphyrin in the urine.\nsynonyms :\n'}


{'id': 'HP_0033628', 'url': 'http://purl.obolibrary.org/obo/HP_0033628', 'lbl': 'Bowel irritability', 'desc': 'label: Bowel irritability\ndefinition : Intermittent abdominal pain with diarrhea and/or constipation.\nsynonyms :\n'}


{'id': 'HP_0033629', 'url': 'http://purl.obolibrary.org/obo/HP_0033629', 'lbl': 'IgG4 autoimmune antibody positivity', 'desc': "label: IgG4 autoimmune antibody positivity\ndefinition : The presence of an antibody of subclass IgG4 in the blood circulation that is directed against the organism's own cells or tissues.\nsynonyms :\n"}


{'id': 'HP_0033630', 'url': 'http://purl.obolibrary.org/obo/HP_0033630', 'lbl': 'Brain fog', 'desc': 'label: Brain fog\ndefinition : Brain fog is a type of transient cognitive dysfunction that comprises a constellation of symptoms that impair intellectual functioning to a level that interferes with daily activities, commonly including forgetfulness, mental slowness, difficulty thinking or focusing, a perceived slowing of mental processing speed, inability to find the right words, a sensation that the mind went blank or is "cloudy". Brain fog tends to recur and may be triggered by factors such as physical fatigue, lack of sleep, and prolonged standing or may appear to occur spontaneously.\nsynonyms :Mental clouding; Mental fatigue; Mental fog\n'}


{'id': 'HP_0033631', 'url': 'http://purl.obolibrary.org/obo/HP_0033631', 'lbl': 'Spondylitis', 'desc': 'label: Spondylitis\ndefinition : Inflammation of the vertebrae (vertebral bodies) or spine.\nsynonyms :\n'}


{'id': 'HP_0033632', 'url': 'http://purl.obolibrary.org/obo/HP_0033632', 'lbl': 'Abnormal alveolar volume', 'desc': 'label: Abnormal alveolar volume\ndefinition : Alveolar volume (VA) is a volume accessible during 10-second breath-hold, measured during a single breath manouver. VA is calculated by knowing the fractional concentration of the tracer gas (eg helium) and the volume of the gas inhaled. VA = Vi*(Fi tracer/Fa tracer). In this equation, Vi = inspired volume of tracer gas, Fi tracer= inspired fraction of tracer gas, Fa tracer = alveolar (exhaled) fraction of tracer gas.\nsynonyms :\n'}


{'id': 'HP_0033633', 'url': 'http://purl.obolibrary.org/obo/HP_0033633', 'lbl': 'Decreased alveolar volume', 'desc': 'label: Decreased alveolar volume\ndefinition : An abnormal reduction in alveolar volume.\nsynonyms :\n'}


{'id': 'HP_0033634', 'url': 'http://purl.obolibrary.org/obo/HP_0033634', 'lbl': 'Increased alveolar volume', 'desc': 'label: Increased alveolar volume\ndefinition : An abnormal elevation in alveolar volume.\nsynonyms :\n'}


{'id': 'HP_0033635', 'url': 'http://purl.obolibrary.org/obo/HP_0033635', 'lbl': 'Post-capillary pulmonary hypertension', 'desc': 'label: Post-capillary pulmonary hypertension\ndefinition : Post-capillary pulmonary hypertension is a hemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP greater than 20 mmHg) and pulmonary artery wedge pressure (PAWP greater than 15 mmHg) and pulmonary vascular resistance (PVR less than 3 Wood units).\nsynonyms :Postcapillary pulmonary hypertension\n'}


{'id': 'HP_0033636', 'url': 'http://purl.obolibrary.org/obo/HP_0033636', 'lbl': 'Combined pre- and post-capillary pulmonary hypertension', 'desc': 'label: Combined pre- and post-capillary pulmonary hypertension\ndefinition : Combined pre- and post-capillary pulmonary hypertension is a haemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary artery wedge pressure (PAWP over 15 mmHg) and pulmonary vascular resistance (PVR at least 3 Wodd units).\nsynonyms :\n'}


{'id': 'HP_0033637', 'url': 'http://purl.obolibrary.org/obo/HP_0033637', 'lbl': 'Anti-endomysial antibody positivity', 'desc': 'label: Anti-endomysial antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endomysial tissue transglutaminase 2 (tTG2).\nsynonyms :Anti-transglutaminase 2 antibody positivity\n'}


{'id': 'HP_0033638', 'url': 'http://purl.obolibrary.org/obo/HP_0033638', 'lbl': 'Intralobular septal thickening', 'desc': 'label: Intralobular septal thickening\ndefinition : Intralobular septal thickening is a computed tomography finding of increased width of the walls (septa) within a pulmonary lobule. Secondary pulmonary lobules represent a cluster of up to 30 acini 9 supplied by a common distal pulmonary artery and bronchiole. These clustered acini are bounded by interstitial fibrous septa (interlobular septa) which outline an irregular polyhedron of varying size between 1 and 2.5 cm. Interlobular septal thickening is seen on chest radiographs as thin linear opacities at right angles to and in contact with the lateral pleural surfaces near the lung bases. In contrast, intralobular septal thickening are visible as fine linear opacities in a lobule when the intralobular interstitial tissue is abnormally thickened. When numerous, they may appear as a fine reticular pattern.\nsynonyms :Intralobular lines\n'}


{'id': 'HP_0033639', 'url': 'http://purl.obolibrary.org/obo/HP_0033639', 'lbl': 'Septic pulmonary embolism', 'desc': 'label: Septic pulmonary embolism\ndefinition : Embolization of intravascular thrombus containing microorganisms into the pulmonary parenchyma via arterial system. Septic pulmonary embolism (PE) can be associated with multiple additional clinical manifestations such as fever, tachypnea, and hemoptysis. This HPO term refers to the finding of the septic embolus in the lung, which can be inferred from radiological findings. Typical radiographic features of septic PE include patchy air space lesions simulating non-specific bronchopneumonia; multiple ill defined round or wedge shaped densities of varying sizes from approximately 0.5 to 3.5 cm located peripherally; lesions abutting the pleura and located at the end of vessels (feeding vessel sign) seen on chest CT scans. Other pulmonary features suggesting septic PE include bilateral, occasional unilateral, rapid progression of cavities or abscess formations.\nsynonyms :Septic pulmonary emboli\n'}


{'id': 'HP_0033640', 'url': 'http://purl.obolibrary.org/obo/HP_0033640', 'lbl': 'Acetabular erosions', 'desc': 'label: Acetabular erosions\ndefinition : Erosion (loss of substance) of the acetabular subchondral cortical bone. The acetabulum is the concave surface that meets with the head of the femur, forming the hip joint.\nsynonyms :\n'}


{'id': 'HP_0033641', 'url': 'http://purl.obolibrary.org/obo/HP_0033641', 'lbl': 'Aortic valve leaflet calcification', 'desc': 'label: Aortic valve leaflet calcification\ndefinition : Deposition of calcium salts in the leaflets (cusps) of the aortic valve.\nsynonyms :Aortic cusp calcification; Aortic valve cusp calcification\n'}


{'id': 'HP_0033642', 'url': 'http://purl.obolibrary.org/obo/HP_0033642', 'lbl': 'Mitral valve leaflet calcification', 'desc': 'label: Mitral valve leaflet calcification\ndefinition : Deposition of calcium salts in the leaflets (cusps) of the mitral valve.\nsynonyms :\n'}


{'id': 'HP_0033643', 'url': 'http://purl.obolibrary.org/obo/HP_0033643', 'lbl': 'Increased circulating very long-chain fatty acid concentration', 'desc': 'label: Increased circulating very long-chain fatty acid concentration\ndefinition : Increased concentation of very long-chain fatty acids in the blood circulation. Very long-chain fatty acids are fatty acids (FAs) with a chain-length of 22 or more carbons.\nsynonyms :Increased plasma levels of very long-chain fatty acid\n'}


{'id': 'HP_0033644', 'url': 'http://purl.obolibrary.org/obo/HP_0033644', 'lbl': 'Elevated circulating erythropoietin concentration', 'desc': 'label: Elevated circulating erythropoietin concentration\ndefinition : Increased concentration of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production.\nsynonyms :Elevated circulating erythropoietin\n'}


{'id': 'HP_0033645', 'url': 'http://purl.obolibrary.org/obo/HP_0033645', 'lbl': 'Midline brainstem cleft', 'desc': 'label: Midline brainstem cleft\ndefinition : A developmental defect characterized by an abnormal cleft (V-shaped indentation of the stalklike part of the brain consisting of the medulla oblongata, the midbrain, and the pons.\nsynonyms :\n'}


{'id': 'HP_0033646', 'url': 'http://purl.obolibrary.org/obo/HP_0033646', 'lbl': 'Absent hippocampal commissure', 'desc': 'label: Absent hippocampal commissure\ndefinition : Absence of the fibers that connect the contralateral hippocampi via the crura of the fornix and run beneath the posterior portion of the corpus callosum.\nsynonyms :Agenesis of the hippocampal commissure\n'}


{'id': 'HP_0033647', 'url': 'http://purl.obolibrary.org/obo/HP_0033647', 'lbl': 'Silhouette sign', 'desc': 'label: Silhouette sign\ndefinition : The silhouette sign is the absence of depiction of an anatomic soft-tissue border. It is caused by consolidation and/or atelectasis of the adjacent lung, by a large mass, or by contiguous pleural fluid. The silhouette sign results from the juxtaposition of structures of similar radiographic attenuation. The sign actually refers to the absence of a silhouette.\nsynonyms :\n'}


{'id': 'HP_0033648', 'url': 'http://purl.obolibrary.org/obo/HP_0033648', 'lbl': 'Pulmonary pseudocavity', 'desc': 'label: Pulmonary pseudocavity\ndefinition : A pseudocavity appears as an oval or round area of low attenuation in lung nodules, masses, or areas of consolidation that represent spared parenchyma, normal or ectatic bronchi, or focal emphysema rather than cavitation. These pseudocavities usually measure less than 1 cm in diameter. They have been described in patients with adenocarcinoma, bronchioloalveolar carcinoma, and benign conditions such as infectious pneumonia.\nsynonyms :\n'}


{'id': 'HP_0033649', 'url': 'http://purl.obolibrary.org/obo/HP_0033649', 'lbl': 'Paraseptal emphysema', 'desc': 'label: Paraseptal emphysema\ndefinition : Paraseptal emphysema is characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa. This emphysema is characterized by subpleural and peribronchovascular regions of low attenuation separated by intact interlobular septa, sometimes associated with bullae.\nsynonyms :Distal acinar emphysema\n'}


{'id': 'HP_0033650', 'url': 'http://purl.obolibrary.org/obo/HP_0033650', 'lbl': 'Pulmonary parenchymal band', 'desc': 'label: Pulmonary parenchymal band\ndefinition : A parenchymal band is a linear opacity, usually 1-3 mm thick and up to 5 cm long that usually extends to the visceral pleura\n(which is often thickened and may be retracted at the site of contact). It reflects pleuroparenchymal fibrosis and is usually associated with distortion of the lung architecture. Parenchymal bands are most frequently encountered in individuals who have been exposed to asbestos.\nsynonyms :\n'}


{'id': 'HP_0033651', 'url': 'http://purl.obolibrary.org/obo/HP_0033651', 'lbl': 'Pulmonary mycetoma', 'desc': 'label: Pulmonary mycetoma\ndefinition : A mycetoma is a discrete mass of intertwined hyphae, usually of an Aspergillus species, matted together by mucus, fibrin, and cellular debris colonizing a cavity, usually from prior fibrocavitary disease (eg, tuberculosis or sarcoidosis). A mycetoma may move to a dependent location when the patient changes position and may show an air crescent sign. CT scans may show a spongelike pattern and foci of calcification in the mycetoma.\nsynonyms :Lung fungus ball\n'}


{'id': 'HP_0033652', 'url': 'http://purl.obolibrary.org/obo/HP_0033652', 'lbl': 'Broncholith', 'desc': 'label: Broncholith\ndefinition : A broncholith, a calcified peribronchial lymph node that erodes into an adjacent bronchus, is most often the consequence of Histoplasma or tuberculous infection. The imaging appearance is of a small calcific focus in or immediately adjacent to an airway, most frequently the right middle lobe bronchus. Broncholiths are readily identified on CT scans. Distal obstructive changes may include atelectasis, mucoid impaction, and bronchiectasis\nsynonyms :\n'}


{'id': 'HP_0033653', 'url': 'http://purl.obolibrary.org/obo/HP_0033653', 'lbl': 'Bronchocele', 'desc': 'label: Bronchocele\ndefinition : A bronchocele is bronchial dilatation due to retained secretions (mucoid impaction) usually caused by proximal obstruction, either congenital (eg, bronchial atresia) or acquired (eg, obstructing cancer). A bronchocele is a tubular or branching Y-or V-shaped structure that may resemble a gloved finger. The CT attenuation of the mucus is generally that of soft tissue but may be modified by its composition (eg, high-attenuation material in allergic bronchopulmonary aspergillosis). In the case of bronchial atresia, the surrounding lung may be of decreased attenuation because of reduced ventilation and, thus, perfusion.\nsynonyms :\n'}


{'id': 'HP_0033654', 'url': 'http://purl.obolibrary.org/obo/HP_0033654', 'lbl': 'Beaded septum sign', 'desc': 'label: Beaded septum sign\ndefinition : Irregular and nodular thickening of interlobular septa reminiscent of a row of beads.\nsynonyms :\n'}


{'id': 'HP_0033655', 'url': 'http://purl.obolibrary.org/obo/HP_0033655', 'lbl': 'Pulmonary cavity', 'desc': 'label: Pulmonary cavity\ndefinition : A gas-filled space, seen as lucency or low-attenuation area, within a nodule, mass or area of parenchymal consolidations. It has a clearly defined wall over 4 mm thick.\nsynonyms :Pulmonary cavern\n'}


{'id': 'HP_0033656', 'url': 'http://purl.obolibrary.org/obo/HP_0033656', 'lbl': 'Juxtaphrenic peak', 'desc': 'label: Juxtaphrenic peak\ndefinition : A juxtaphrenic peak is a small triangular opacity based at the apex of the dome of a hemidiaphragm, associated with upper lobe volume loss of any cause (eg, postirradiation fibrosis or upper lobectomy). It is most readily appreciated on a frontal chest radiograph. The peak is caused by upward retraction of the inferior accessory fissure or an intrapulmonary septum associated with the pulmonary ligament.\nsynonyms :\n'}


{'id': 'HP_0033657', 'url': 'http://purl.obolibrary.org/obo/HP_0033657', 'lbl': 'Linear atelectasis', 'desc': 'label: Linear atelectasis\ndefinition : Linear atelectasis is a focal area of subsegmental atelectasis with a linear configuration, almost always extending to the pleura. It is commonly horizontal but sometimes oblique or vertical. The thickness of the atelectasis may range from a few millimeters to more than 1 cm.\nsynonyms :Discoid atelectasis; Platelike atelectasis\n'}


{'id': 'HP_0033658', 'url': 'http://purl.obolibrary.org/obo/HP_0033658', 'lbl': 'Rounded atelectasis', 'desc': 'label: Rounded atelectasis\ndefinition : Rounded atelectasis is rounded collapsed lung associated with invaginated fibrotic pleura and thickened and fibrotic interlobular septa. Most frequently, it is the consequence of an asbestos-induced exudative pleural effusion with resultant pleural scarring, but it may occur with any cause of pleural fibrosis. On chest radiographs, rounded atelectasis appears as a mass abutting a pleural surface, usually in the posterior part of a lower lobe. Distorted vessels have a curvilinear disposition as they converge on the mass (the comet tail sign). The degree of lobar retraction depends on the volume of atelectatic lung. It is almost invariably associated with other signs of pleural fibrosis (eg, blunting of costophrenic angle). CT is more sensitive for the detection and display of the characteristic features of rounded atelectasis. An additional sign is homogeneous uptake of contrast medium in the atelectatic lung.\nsynonyms :Blesovsky syndrome; Comet tail sign; Folded lung syndrome; Helical atelectasis; Pleural pseudotumor; Pleuroma\n'}


{'id': 'HP_0033659', 'url': 'http://purl.obolibrary.org/obo/HP_0033659', 'lbl': 'obsolete Crazy-paving pattern', 'desc': 'label: obsolete Crazy-paving pattern\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033660', 'url': 'http://purl.obolibrary.org/obo/HP_0033660', 'lbl': 'Hand paresthesia', 'desc': 'label: Hand paresthesia\ndefinition : Tingling (often refered to as a pins and needles feeling) and numbness in the hand.\nsynonyms :Hand tingling\n'}


{'id': 'HP_0033661', 'url': 'http://purl.obolibrary.org/obo/HP_0033661', 'lbl': 'Air crescent', 'desc': 'label: Air crescent\ndefinition : An air crescent is a collection of air in a crescentic shape that separates the wall of a cavity from an inner mass. The air crescent sign is often considered characteristic of either Aspergillus colonization of preexisting cavities or retraction of infarcted lung in angioinvasive aspergillosis. However, the air crescent sign has also been reported in other conditions, including tuberculosis, Wegener granulomatosis, intracavitary hemorrhage, and lung cancer.\nsynonyms :\n'}


{'id': 'HP_0033662', 'url': 'http://purl.obolibrary.org/obo/HP_0033662', 'lbl': 'Air bronchogram', 'desc': 'label: Air bronchogram\ndefinition : An air bronchogram is a pattern of air-filled (low-attenuation) bronchi on a background of opaque (high-attenuation) airless lung. The sign implies (a) patency of proximal airways and (b) evacuation of alveolar air by means of absorption (atelectasis) or replacement (eg, pneumonia) or a combination of these processes. In rare cases, the displacement of air is the result of marked interstitial expansion (eg, lymphoma).\nsynonyms :\n'}


{'id': 'HP_0033663', 'url': 'http://purl.obolibrary.org/obo/HP_0033663', 'lbl': 'Air trapping', 'desc': 'label: Air trapping\ndefinition : Air trapping is retention of air in the lung distal to an obstruction (usually partial). Air trapping is seen on end-expiration CT scans as parenchymal areas with less than normal increase in attenuation and lack of volume reduction. Comparison between inspiratory and expiratory CT scans can be helpful when air trapping is subtle or diffuse.\nsynonyms :\n'}


{'id': 'HP_0033664', 'url': 'http://purl.obolibrary.org/obo/HP_0033664', 'lbl': 'Ganglioglioma', 'desc': 'label: Ganglioglioma\ndefinition : Gangliogliomas are rare tumors of the central nervous system. The are WHO grade I and considered low grade. They are well differentiated neuroepithelial tumors consisting of both dysplastic neuronal and neoplastic glial cells.\nsynonyms :\n'}


{'id': 'HP_0033665', 'url': 'http://purl.obolibrary.org/obo/HP_0033665', 'lbl': 'Diminished health-related quality of life', 'desc': "label: Diminished health-related quality of life\ndefinition : A reduction in an individual's subjective assessment of his or her sense of well-being and ability to perform social roles.\nsynonyms :\n"}


{'id': 'HP_0033666', 'url': 'http://purl.obolibrary.org/obo/HP_0033666', 'lbl': 'Diminished physical functioning', 'desc': "label: Diminished physical functioning\ndefinition : A reduction in the ability to perform activities of daily living as compared to previous abilities because of functional deficits due to illness. The 36-item Short Form (SF-36) health survey questionnaire is one of many methods used to measure patients' perceptions of diminished physical functioning.\nsynonyms :Decline in physical functional health; Diminished physical health\n"}


{'id': 'HP_0033667', 'url': 'http://purl.obolibrary.org/obo/HP_0033667', 'lbl': 'Diminished mental health', 'desc': 'label: Diminished mental health\ndefinition : A reduction in the subjective feeling of mental well being.\nsynonyms :Mental impairment; Reduced mental health\n'}


{'id': 'HP_0033668', 'url': 'http://purl.obolibrary.org/obo/HP_0033668', 'lbl': 'Abnormal amygdala morphology', 'desc': 'label: Abnormal amygdala morphology\ndefinition : A structural anomaly of the amygdala.\nsynonyms :Abnormal morphology of the amygdala\n'}


{'id': 'HP_0033669', 'url': 'http://purl.obolibrary.org/obo/HP_0033669', 'lbl': 'Enlarged amygdala', 'desc': 'label: Enlarged amygdala\ndefinition : A increase in the volume (size) of the amygdyla.\nsynonyms :Amygdalar enlargement\n'}


{'id': 'HP_0033670', 'url': 'http://purl.obolibrary.org/obo/HP_0033670', 'lbl': 'Organizing pneumonia', 'desc': 'label: Organizing pneumonia\ndefinition : Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities.\nsynonyms :\n'}


{'id': 'HP_0033671', 'url': 'http://purl.obolibrary.org/obo/HP_0033671', 'lbl': 'Pulmonary oligemia', 'desc': 'label: Pulmonary oligemia\ndefinition : Oligemia is a reduction in pulmonary blood volume. Most frequently, this reduction is regional, but occasionally it is generalized. Regional oligemia is usually associated with reduced blood flow in the oligemic area. Oligemia appears as a regional or widespread decrease in the size and number of identifiable pulmonary vessels, which is indicative of less than normal blood flow.\nsynonyms :\n'}


{'id': 'HP_0033672', 'url': 'http://purl.obolibrary.org/obo/HP_0033672', 'lbl': 'Positive carpal Tinel sign', 'desc': 'label: Positive carpal Tinel sign\ndefinition : The Tinel test is performed by lightly tapping (percussing) over the median nerve. It is positive (abnormal) if the patient experiences pain and paresthesias (tingling, numbness) along the distribution of the median nerve.\nsynonyms :Positive carpal Hoffmann Tinel sign\n'}


{'id': 'HP_0033673', 'url': 'http://purl.obolibrary.org/obo/HP_0033673', 'lbl': 'Positive Phalen test', 'desc': 'label: Positive Phalen test\ndefinition : The Phalen maneuver is performed by having the patient hold both wrists in complete and forced flexion (pushing the dorsal surfaces of both hands together) for 30-60 seconds. This can increase the pressure in the carpal tunnel. The test is positive (abnormal) if the patient experiences characteristic symptoms of carpal tunnel syndrome (pain and paresthesias along the distribution of the median nerve, i.e., thumb, index finger, and middle finger).\nsynonyms :Phalen maneuver; Phalen manoeuvre\n'}


{'id': 'HP_0033674', 'url': 'http://purl.obolibrary.org/obo/HP_0033674', 'lbl': 'Pulmonary blood flow redistribution', 'desc': 'label: Pulmonary blood flow redistribution\ndefinition : Pulmonary blood flow redistribution refers to any departure from the normal distribution of blood flow in the lungs that is caused by an increase in pulmonary vascular resistance elsewhere in the pulmonary vascular bed. Pulmonary blood flow redistribution is indicated by a decrease in the size and/or number of visible pulmonary vessels in one or more lung regions, with a corresponding increase in number and/or size of pulmonary vessels in other parts of the lung.\nsynonyms :\n'}


{'id': 'HP_0033675', 'url': 'http://purl.obolibrary.org/obo/HP_0033675', 'lbl': 'Frailty', 'desc': 'label: Frailty\ndefinition : A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised.\nsynonyms :\n'}


{'id': 'HP_0033676', 'url': 'http://purl.obolibrary.org/obo/HP_0033676', 'lbl': 'Posttraumatic stress symptom', 'desc': 'label: Posttraumatic stress symptom\ndefinition : A behavioral or psychological symptom that typically occurs following exposure to one or more traumatic events. Posttraumatic stress disorder (PTSD) symptoms include intrusive recollections (re-experiencing the trauma in flashbacks, memories or nightmares); avoidant and numbing symptoms (including diminished emotions and avoidance of situations that are reminders of the traumatic event); and hyperarousal (including increased irritability, exaggerated startle reactions or difficulty sleeping or concentrating).\nsynonyms :PTSD\n'}


{'id': 'HP_0033677', 'url': 'http://purl.obolibrary.org/obo/HP_0033677', 'lbl': 'Acute respiratory distress syndrome', 'desc': "label: Acute respiratory distress syndrome\ndefinition : Acute respiratory distress syndrome (ARDS) is defined as an acute disorder that starts within seven days of the inciting event and is characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. ARDS is defined by the patient's oxygen in arterial blood (PaO2) to the fraction of the oxygen in the inspired air (FiO2). These patients have a PaO2/FiO2 ratio of less than 300.\nsynonyms :ARDS\n"}


{'id': 'HP_0033678', 'url': 'http://purl.obolibrary.org/obo/HP_0033678', 'lbl': 'Acute coronary syndrome', 'desc': 'label: Acute coronary syndrome\ndefinition : The term acute coronary syndrome (ACS) refers to any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI).\nsynonyms :\n'}


{'id': 'HP_0033679', 'url': 'http://purl.obolibrary.org/obo/HP_0033679', 'lbl': 'Abnormal red nucleus morphology', 'desc': 'label: Abnormal red nucleus morphology\ndefinition : Any structural anomaly of the red nucleus, a part of the midbrain involved in control of movement.\nsynonyms :\n'}


{'id': 'HP_0033680', 'url': 'http://purl.obolibrary.org/obo/HP_0033680', 'lbl': 'Pilocytic astrocytoma', 'desc': 'label: Pilocytic astrocytoma\ndefinition : The most common form of astrocytoma (WHO Grade I) in childhood. These typically have MAPK signalling pathway abnormalities.\nsynonyms :\n'}


{'id': 'HP_0033681', 'url': 'http://purl.obolibrary.org/obo/HP_0033681', 'lbl': 'Oligodendroglioma', 'desc': 'label: Oligodendroglioma\ndefinition : Oligodendroglioma is a type of diffusely infiltrating glioma and constitutes approximately 5% of primary intracranial tumors. They often involve the cortical gray matter and are most commonly seen in the frontal lobes. OGs are generally low grade WHO grade II neoplasms that are slow-growing tumors and have a favorable treatment response when compared to other gliomas. Grade III anaplastic OG is a more malignant form of the tumor which portends a less favorable prognosis and may occur de novo or as degeneration from the lower grade OG.\nsynonyms :\n'}