{'id': 'HP_0031818', 'url': 'http://purl.obolibrary.org/obo/HP_0031818', 'lbl': 'Abnormal waist to hip ratio', 'desc': 'label: Abnormal waist to hip ratio\ndefinition : A deviation from normal of the waist to hip ratio, defined as the waist measurement divided by hip measurement.\nsynonyms :\n'}


{'id': 'HP_0031819', 'url': 'http://purl.obolibrary.org/obo/HP_0031819', 'lbl': 'Increased waist to hip ratio', 'desc': 'label: Increased waist to hip ratio\ndefinition : Increased waist-to-hip ratio (WHR) is a measurement above the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement.\nsynonyms :Increased WHR; Increased waist-hip ratio; Increased waist-to-hip ratio\n'}


{'id': 'HP_0031820', 'url': 'http://purl.obolibrary.org/obo/HP_0031820', 'lbl': 'Decreased waist to hip ratio', 'desc': 'label: Decreased waist to hip ratio\ndefinition : Decreased waist-to-hip ratio (WHR) is a measurement below the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement.\nsynonyms :Decreased WHR; Decreased waist-hip ratio; Decreased waist-to-hip ratio\n'}


{'id': 'HP_0031821', 'url': 'http://purl.obolibrary.org/obo/HP_0031821', 'lbl': 'Abnormal hypoxanthine-guanine phosphoribosyltransferase level', 'desc': 'label: Abnormal hypoxanthine-guanine phosphoribosyltransferase level\ndefinition : Altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.\nsynonyms :Abnormal 6-hydroxypurine phosphoribosyltransferase level; Abnormal GMP pyrophosphorylase level; Abnormal GPRT level\n'}


{'id': 'HP_0031822', 'url': 'http://purl.obolibrary.org/obo/HP_0031822', 'lbl': 'Elevated hypoxanthine-guanine phosphoribosyltransferase level', 'desc': 'label: Elevated hypoxanthine-guanine phosphoribosyltransferase level\ndefinition : Abnormally increased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.\nsynonyms :Elevated 6-hydroxypurine phosphoribosyltransferase level; Elevated 6-mercaptopurine phosphoribosyltransferase level; Elevated GMP pyrophosphorylase level\n'}


{'id': 'HP_0031823', 'url': 'http://purl.obolibrary.org/obo/HP_0031823', 'lbl': 'Reduced hypoxanthine-guanine phosphoribosyltransferase level', 'desc': 'label: Reduced hypoxanthine-guanine phosphoribosyltransferase level\ndefinition : Abnormally decreased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.\nsynonyms :Reduced 6-hydroxypurine phosphoribosyltransferase level; Reduced 6-mercaptopurine phosphoribosyltransferase level; Reduced GMP pyrophosphorylase level\n'}


{'id': 'HP_0031824', 'url': 'http://purl.obolibrary.org/obo/HP_0031824', 'lbl': 'Hepatic mastocytosis', 'desc': 'label: Hepatic mastocytosis\ndefinition : Liver mast cell infiltration.\nsynonyms :\n'}


{'id': 'HP_0031825', 'url': 'http://purl.obolibrary.org/obo/HP_0031825', 'lbl': 'Freezing of gait', 'desc': 'label: Freezing of gait\ndefinition : Freezing of gait is defined as a brief, episodic absence or marked reduction of forward progression of the feet despite the intention to walk.\nsynonyms :Freezing gait\n'}


{'id': 'HP_0031826', 'url': 'http://purl.obolibrary.org/obo/HP_0031826', 'lbl': 'Abnormal reflex', 'desc': 'label: Abnormal reflex\ndefinition : Any anomaly of a reflex, i.e., of an automatic response mediated by the nervous system (a reflex does not need the intervention of conscious thought to occur).\nsynonyms :\n'}


{'id': 'HP_0031827', 'url': 'http://purl.obolibrary.org/obo/HP_0031827', 'lbl': 'Absent abdominal reflex', 'desc': 'label: Absent abdominal reflex\ndefinition : Lack of contraction of abdominal muscles in the quadrant of the abdomen that is stimulated by scraping the skin tangential to or toward the umbilicus.\nsynonyms :Abdominal reflex absent\n'}


{'id': 'HP_0031828', 'url': 'http://purl.obolibrary.org/obo/HP_0031828', 'lbl': 'Abnormal superficial reflex', 'desc': 'label: Abnormal superficial reflex\ndefinition : An anomaly of a reflex that is elicited as a motor response to scraping of the skin. They are generally graded as present or absent. They differ from tendon reflexes in that the sensory signal must ascend the spinal cord to reach the brain and then descend the spinal cord to reach the motor neurons.\nsynonyms :\n'}


{'id': 'HP_0031829', 'url': 'http://purl.obolibrary.org/obo/HP_0031829', 'lbl': 'Absent cremaster reflex', 'desc': 'label: Absent cremaster reflex\ndefinition : Lack of response to scratching of the skin of the medial thigh, which in males normally elicits a brisk, short elevation of the ipsilateral testis, a phenomenon that is referred to as the cremaster reflex.\nsynonyms :Absent cremasteric reflex\n'}


{'id': 'HP_0031830', 'url': 'http://purl.obolibrary.org/obo/HP_0031830', 'lbl': 'Pinguecula', 'desc': 'label: Pinguecula\ndefinition : A pinguecula is a yellowish to brown protruding lesion in the conjunctiva that is easily seen on the nasal and temporal sides of the cornea.\nsynonyms :\n'}


{'id': 'HP_0031831', 'url': 'http://purl.obolibrary.org/obo/HP_0031831', 'lbl': 'Decreased serum zinc', 'desc': 'label: Decreased serum zinc\ndefinition : A reduced concentration of zinc in the blood.\nsynonyms :\n'}


{'id': 'HP_0031832', 'url': 'http://purl.obolibrary.org/obo/HP_0031832', 'lbl': 'Hypermetric downward saccades', 'desc': 'label: Hypermetric downward saccades\ndefinition : Overshoot of downward saccadic eye movements.\nsynonyms :\n'}


{'id': 'HP_0031833', 'url': 'http://purl.obolibrary.org/obo/HP_0031833', 'lbl': 'Hypometric upward saccades', 'desc': 'label: Hypometric upward saccades\ndefinition : Saccadic undershoot of upward saccadic eye movements, i.e., an upward saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object.\nsynonyms :\n'}


{'id': 'HP_0031834', 'url': 'http://purl.obolibrary.org/obo/HP_0031834', 'lbl': 'Aortopulmonary collateral arteries', 'desc': 'label: Aortopulmonary collateral arteries\ndefinition : Small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus.\nsynonyms :\n'}


{'id': 'HP_0031835', 'url': 'http://purl.obolibrary.org/obo/HP_0031835', 'lbl': 'Abnormal superoxide dismutase level', 'desc': 'label: Abnormal superoxide dismutase level\ndefinition : An abnormal level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.\nsynonyms :Abnormal superoxide:superoxide oxidoreductase activity\n'}


{'id': 'HP_0031836', 'url': 'http://purl.obolibrary.org/obo/HP_0031836', 'lbl': 'Increased superoxide dismutase level', 'desc': 'label: Increased superoxide dismutase level\ndefinition : Increased level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.\nsynonyms :Increased superoxide:superoxide oxidoreductase activity\n'}


{'id': 'HP_0031837', 'url': 'http://purl.obolibrary.org/obo/HP_0031837', 'lbl': 'Decreased superoxide dismutase level', 'desc': 'label: Decreased superoxide dismutase level\ndefinition : Decreased level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.\nsynonyms :Decreased superoxide:superoxide oxidoreductase activity\n'}


{'id': 'HP_0031838', 'url': 'http://purl.obolibrary.org/obo/HP_0031838', 'lbl': 'Presence of xenobiotic', 'desc': 'label: Presence of xenobiotic\ndefinition : Presence of a chemical substance found within an individual that is not naturally produced or expected to be present in human tissues or bodily fluids.\nsynonyms :\n'}


{'id': 'HP_0031840', 'url': 'http://purl.obolibrary.org/obo/HP_0031840', 'lbl': 'Urine xenobiotic', 'desc': 'label: Urine xenobiotic\ndefinition : The presence of a xenobiotic in urine.\nsynonyms :\n'}


{'id': 'HP_0031841', 'url': 'http://purl.obolibrary.org/obo/HP_0031841', 'lbl': 'Positive urine methadone test', 'desc': 'label: Positive urine methadone test\ndefinition : Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in urine.\nsynonyms :\n'}


{'id': 'HP_0031842', 'url': 'http://purl.obolibrary.org/obo/HP_0031842', 'lbl': 'Lymphangiectasis', 'desc': 'label: Lymphangiectasis\ndefinition : Dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma.\nsynonyms :Lymphangiectasia\n'}


{'id': 'HP_0031843', 'url': 'http://purl.obolibrary.org/obo/HP_0031843', 'lbl': 'Bradyphrenia', 'desc': 'label: Bradyphrenia\ndefinition : Abnormal slowness of thought processes.\nsynonyms :Mental slowness; Slowed thinking; Slowed thoughts; Slowness of thought\n'}


{'id': 'HP_0031844', 'url': 'http://purl.obolibrary.org/obo/HP_0031844', 'lbl': 'Euphoria', 'desc': 'label: Euphoria\ndefinition : A sense of intense joy or happiness that is beyond what would be expected under the given circumstances.\nsynonyms :\n'}


{'id': 'HP_0031845', 'url': 'http://purl.obolibrary.org/obo/HP_0031845', 'lbl': 'Abnormal libido', 'desc': 'label: Abnormal libido\ndefinition : Any deviation from the normal sexual drive or desire for sexual activity.\nsynonyms :\n'}


{'id': 'HP_0031846', 'url': 'http://purl.obolibrary.org/obo/HP_0031846', 'lbl': 'Femur fracture', 'desc': 'label: Femur fracture\ndefinition : A break or crush injury of the thigh bone (femur).\nsynonyms :Femoral fracture\n'}


{'id': 'HP_0031847', 'url': 'http://purl.obolibrary.org/obo/HP_0031847', 'lbl': 'Difficulty walking backward', 'desc': 'label: Difficulty walking backward\ndefinition : Reduced ability to walk (ambulate) in a backwards direction.\nsynonyms :\n'}


{'id': 'HP_0031848', 'url': 'http://purl.obolibrary.org/obo/HP_0031848', 'lbl': 'Cock-walk gait', 'desc': 'label: Cock-walk gait\ndefinition : An abnormality of gait that can be observed in individuals with dystonic posture in which the individual walks with an extended trunk and flexed arms, while strutting on the toes without the heels touching the floor.\nsynonyms :\n'}


{'id': 'HP_0031849', 'url': 'http://purl.obolibrary.org/obo/HP_0031849', 'lbl': 'Sleep-wake inversion', 'desc': 'label: Sleep-wake inversion\ndefinition : A reversal of sleeping habits with a tendency to sleep during the day and to be awake at night.\nsynonyms :Inverted sleep-wake cycle\n'}


{'id': 'HP_0031850', 'url': 'http://purl.obolibrary.org/obo/HP_0031850', 'lbl': 'Abnormal hematocrit', 'desc': 'label: Abnormal hematocrit\ndefinition : Any deviation from the normal ratio of the volume of red blood cells to the total volume of blood.\nsynonyms :Abnormal Hct\n'}


{'id': 'HP_0031851', 'url': 'http://purl.obolibrary.org/obo/HP_0031851', 'lbl': 'Reduced hematocrit', 'desc': 'label: Reduced hematocrit\ndefinition : A reduction below the normal ratio of the volume of red blood cells to the total volume of blood.\nsynonyms :Low hematocrit; Reduced Hct\n'}


{'id': 'HP_0031853', 'url': 'http://purl.obolibrary.org/obo/HP_0031853', 'lbl': 'Isomerism', 'desc': 'label: Isomerism\ndefinition : Isomerism in the context of the congenitally malformed heart is defined as a situation where some paired structures on opposite sides of the left-right axis of the body are, in morphologic terms, symmetrical mirror images of each other.\nsynonyms :\n'}


{'id': 'HP_0031854', 'url': 'http://purl.obolibrary.org/obo/HP_0031854', 'lbl': 'Left Isomerism', 'desc': 'label: Left Isomerism\ndefinition : A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal left-sided structures.\nsynonyms :Left-sided isomerism\n'}


{'id': 'HP_0031855', 'url': 'http://purl.obolibrary.org/obo/HP_0031855', 'lbl': 'Right isomerism', 'desc': 'label: Right isomerism\ndefinition : A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures.\nsynonyms :Right-sided isomerism\n'}


{'id': 'HP_0031856', 'url': 'http://purl.obolibrary.org/obo/HP_0031856', 'lbl': 'Hobby horse gait', 'desc': 'label: Hobby horse gait\ndefinition : An abnormal gait characterized by toe walking, stiff legs, and skipping. The gait pattern has some resemblance to cock-walk gait, but affected individuals are able to improve their dystonic gait by walking backward.\nsynonyms :\n'}


{'id': 'HP_0031857', 'url': 'http://purl.obolibrary.org/obo/HP_0031857', 'lbl': 'Ineffective esophageal peristalsis', 'desc': 'label: Ineffective esophageal peristalsis\ndefinition : Reduced or inadequate esophageal peristalsis, with resultant slow passage of contents through the esophagus.\nsynonyms :Ineffective esophageal motility\n'}


{'id': 'HP_0031858', 'url': 'http://purl.obolibrary.org/obo/HP_0031858', 'lbl': 'Esophageal furrows', 'desc': 'label: Esophageal furrows\ndefinition : Longitudinal grooves in the surface of the esophagus arranged in a longitudinal fashion (from top to bottom of the esophagus).\nsynonyms :\n'}


{'id': 'HP_0031860', 'url': 'http://purl.obolibrary.org/obo/HP_0031860', 'lbl': 'Abnormal heart rate variability', 'desc': 'label: Abnormal heart rate variability\ndefinition : Any abnormality in the variability of the time interval between successive heartbeats.\nsynonyms :\n'}


{'id': 'HP_0031861', 'url': 'http://purl.obolibrary.org/obo/HP_0031861', 'lbl': 'Decreased heart rate variability', 'desc': 'label: Decreased heart rate variability\ndefinition : Reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle.\nsynonyms :Reduced heart rate variability\n'}


{'id': 'HP_0031862', 'url': 'http://purl.obolibrary.org/obo/HP_0031862', 'lbl': 'Increased heart rate variability', 'desc': 'label: Increased heart rate variability\ndefinition : Increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle.\nsynonyms :\n'}


{'id': 'HP_0031863', 'url': 'http://purl.obolibrary.org/obo/HP_0031863', 'lbl': 'Bloodstream infectious agent', 'desc': 'label: Bloodstream infectious agent\ndefinition : The presence of an infectious agent in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0031864', 'url': 'http://purl.obolibrary.org/obo/HP_0031864', 'lbl': 'Bacteremia', 'desc': 'label: Bacteremia\ndefinition : Presence of viable bacteria in the blood.\nsynonyms :Bacteria in blood culture; Bacteria in blood cultures\n'}


{'id': 'HP_0031865', 'url': 'http://purl.obolibrary.org/obo/HP_0031865', 'lbl': 'Abnormal liver physiology', 'desc': 'label: Abnormal liver physiology\ndefinition : Any functional anomaly of the liver.\nsynonyms :Abnormal hepatic physiology\n'}


{'id': 'HP_0031866', 'url': 'http://purl.obolibrary.org/obo/HP_0031866', 'lbl': 'Clasp-knife sign', 'desc': 'label: Clasp-knife sign\ndefinition : Clasp-knife phenomonen refers to increased muscle tone while bending or stretching a limb, whereby there is a sudden relaxation (decrease in resistance) as the muscle continues to be streched. This phenomenon has been likened to opening a clasp knife.\nsynonyms :\n'}


{'id': 'HP_0031867', 'url': 'http://purl.obolibrary.org/obo/HP_0031867', 'lbl': 'Neck hypertonia', 'desc': 'label: Neck hypertonia\ndefinition : Increased passive stiffness or tightness of the neck musculature.\nsynonyms :\n'}


{'id': 'HP_0031868', 'url': 'http://purl.obolibrary.org/obo/HP_0031868', 'lbl': 'Optic ataxia', 'desc': 'label: Optic ataxia\ndefinition : Difficulty reaching to visually guided goals in peripheral vision, with the deficit leaves voluntary eye movements largely unaffected.\nsynonyms :\n'}


{'id': 'HP_0031869', 'url': 'http://purl.obolibrary.org/obo/HP_0031869', 'lbl': 'Recurrent joint dislocation', 'desc': 'label: Recurrent joint dislocation\ndefinition : Dislocation of a given joint repeated times.\nsynonyms :Recurrent joint dislocations\n'}


{'id': 'HP_0031870', 'url': 'http://purl.obolibrary.org/obo/HP_0031870', 'lbl': 'Phosphohydroxylysinuria', 'desc': 'label: Phosphohydroxylysinuria\ndefinition : An elevated concentration of phosphohydroxylysine in the urine.\nsynonyms :\n'}


{'id': 'HP_0031871', 'url': 'http://purl.obolibrary.org/obo/HP_0031871', 'lbl': 'Abnormal Langerhans cell morphology', 'desc': 'label: Abnormal Langerhans cell morphology\ndefinition : Any functional anomaly of Langerhans cells, which are dendritic cells in the epidermis and some other locations. Langerhans cells play roles in immune surveillance and homeostasis.\nsynonyms :\n'}


{'id': 'HP_0031872', 'url': 'http://purl.obolibrary.org/obo/HP_0031872', 'lbl': 'Absent Birbeck granules in Langerhans cells', 'desc': 'label: Absent Birbeck granules in Langerhans cells\ndefinition : Birbeck granules (BG) are cytoplasmic organelles that are only found in Langerhans cells (LC). The function of BG is still not completely understood, although most studies point toward an active role in receptor-mediated endocytosis and participation in the antigen-processing/presenting function of LC. This feature refers to the absence of BG in LC, a feature that can be documented by means of electron microscopy.\nsynonyms :\n'}


{'id': 'HP_0031873', 'url': 'http://purl.obolibrary.org/obo/HP_0031873', 'lbl': 'Early chronotype', 'desc': 'label: Early chronotype\ndefinition : A tendency towards rising very early in the morning and going to bed early in the evening.\nsynonyms :Early sleep onset\n'}


{'id': 'HP_0031874', 'url': 'http://purl.obolibrary.org/obo/HP_0031874', 'lbl': 'Late chronotype', 'desc': 'label: Late chronotype\ndefinition : A tendency towards rising very late in the morning and going to bed late at night.\nsynonyms :Late sleep onset\n'}


{'id': 'HP_0031875', 'url': 'http://purl.obolibrary.org/obo/HP_0031875', 'lbl': 'Abnormal circulating hepcidin concentration', 'desc': 'label: Abnormal circulating hepcidin concentration\ndefinition : Any deviation from the normal concentration of hepcidin in the blood circulation.\nsynonyms :Abnormal hepcidin level\n'}


{'id': 'HP_0031876', 'url': 'http://purl.obolibrary.org/obo/HP_0031876', 'lbl': 'Decreased circulating hepcidin concentration', 'desc': 'label: Decreased circulating hepcidin concentration\ndefinition : Concentration of hepcidin in the blood circulation below the lower limit of normal.\nsynonyms :Decreased hepcidin level\n'}


{'id': 'HP_0031877', 'url': 'http://purl.obolibrary.org/obo/HP_0031877', 'lbl': 'Elevated circulating hepcidin concentration', 'desc': 'label: Elevated circulating hepcidin concentration\ndefinition : Concentration of hepcidin in the blood circulation above the upper limit of normal.\nsynonyms :Elevated hepcidin level\n'}


{'id': 'HP_0031878', 'url': 'http://purl.obolibrary.org/obo/HP_0031878', 'lbl': 'Acromicria', 'desc': 'label: Acromicria\ndefinition : Small hands and feet in proportion to the rest of the body.\nsynonyms :\n'}


{'id': 'HP_0031879', 'url': 'http://purl.obolibrary.org/obo/HP_0031879', 'lbl': 'Abnormal eyelid physiology', 'desc': 'label: Abnormal eyelid physiology\ndefinition : Any functional abnormality of the eyelid.\nsynonyms :\n'}


{'id': 'HP_0031880', 'url': 'http://purl.obolibrary.org/obo/HP_0031880', 'lbl': 'Eyelid laxity', 'desc': 'label: Eyelid laxity\ndefinition : Abnormally lax eyelid associated with tissue relaxation; it can be demonstrated by the eyelid distraction test and/or the eyelid snap test.\nsynonyms :Lid laxity\n'}


{'id': 'HP_0031881', 'url': 'http://purl.obolibrary.org/obo/HP_0031881', 'lbl': 'Decreased tear drainage', 'desc': 'label: Decreased tear drainage\ndefinition : A form of watery eye associated with obstruction of the nasolacrimal system. This may arise at the level of the punctum, the canaliculi, the sac or the nasolacrimal duct.\nsynonyms :\n'}


{'id': 'HP_0031882', 'url': 'http://purl.obolibrary.org/obo/HP_0031882', 'lbl': 'Agyria', 'desc': 'label: Agyria\ndefinition : A congenital abnormality of the cerebral hemisphere characterized by lack of gyrations (convolutions) of the cerebral cortex. Agyria is defined as cortical regions lacking gyration with sulci great than 3 cm apart and cerebral cortex thicker than 5 mm.\nsynonyms :Agyria diffuse\n'}


{'id': 'HP_0031883', 'url': 'http://purl.obolibrary.org/obo/HP_0031883', 'lbl': 'Increased proinsulin:insulin ratio', 'desc': 'label: Increased proinsulin:insulin ratio\ndefinition : An elevated concentration of proinsulin (the prohormone precursor to insulin) to mature insulin in the circulation.\nsynonyms :\n'}


{'id': 'HP_0031884', 'url': 'http://purl.obolibrary.org/obo/HP_0031884', 'lbl': 'Abnormal CSF glucose concentration', 'desc': 'label: Abnormal CSF glucose concentration\ndefinition : A deviation from normal concentration of glucose content in the cerebrospinal fluid.\nsynonyms :Abnormal CSF glucose level\n'}


{'id': 'HP_0031885', 'url': 'http://purl.obolibrary.org/obo/HP_0031885', 'lbl': 'Hyperglycorrhachia', 'desc': 'label: Hyperglycorrhachia\ndefinition : Abnormally high glucose concentration in the cerebrospinal fluid.\nsynonyms :Increased CSF glucose\n'}


{'id': 'HP_0031886', 'url': 'http://purl.obolibrary.org/obo/HP_0031886', 'lbl': 'Abnormal LDL cholesterol concentration', 'desc': 'label: Abnormal LDL cholesterol concentration\ndefinition : Any deviation from the normal concentration of low-density lipoprotein cholesterol in the blood circulation.\nsynonyms :Abnormal LDL-C concentration; Abnormal LDL-C level; Abnormal LDLc concentration\n'}


{'id': 'HP_0031887', 'url': 'http://purl.obolibrary.org/obo/HP_0031887', 'lbl': 'Abnormal chylomicron concentration', 'desc': 'label: Abnormal chylomicron concentration\ndefinition : Any deviation from the normal circulating concentration of chylomicrons.\nsynonyms :\n'}


{'id': 'HP_0031888', 'url': 'http://purl.obolibrary.org/obo/HP_0031888', 'lbl': 'Abnormal HDL cholesterol concentration', 'desc': 'label: Abnormal HDL cholesterol concentration\ndefinition : Any deviation from the normal concentration of high-density lipoprotein cholesterol (HDL) in the blood.\nsynonyms :\n'}


{'id': 'HP_0031889', 'url': 'http://purl.obolibrary.org/obo/HP_0031889', 'lbl': 'Abnormal VLDL cholesterol concentration', 'desc': 'label: Abnormal VLDL cholesterol concentration\ndefinition : Any deviation from the normal concentration of very-low-density lipoprotein cholesterol in the blood.\nsynonyms :\n'}


{'id': 'HP_0031890', 'url': 'http://purl.obolibrary.org/obo/HP_0031890', 'lbl': 'Increased urine urobilinogen', 'desc': 'label: Increased urine urobilinogen\ndefinition : An elevated concentration of urobilinogen in the urine.\nsynonyms :\n'}


{'id': 'HP_0031891', 'url': 'http://purl.obolibrary.org/obo/HP_0031891', 'lbl': 'Decreased eosinophil count', 'desc': 'label: Decreased eosinophil count\ndefinition : Abnormal reduction in the count of eosinophils in the blood per volume.\nsynonyms :\n'}


{'id': 'HP_0031898', 'url': 'http://purl.obolibrary.org/obo/HP_0031898', 'lbl': 'Rouleaux formation', 'desc': 'label: Rouleaux formation\ndefinition : Increased amount of stacking of erythrocytes into long chains. Rouleaux (singular: rouleau) is derived from a French word that can refer to a stack of coins put into a cylindircal paper roll. Rouleaux formation is observed with increased serum proteins, particularly fibrinogen and globulins, and represents the cause of increased erythrocte sedimentation rate because rouleaux sediment more readily than isolated red blood cells.\nsynonyms :Increased rouleaux formation\n'}


{'id': 'HP_0031899', 'url': 'http://purl.obolibrary.org/obo/HP_0031899', 'lbl': 'Abnormal coagulation factor V activity', 'desc': 'label: Abnormal coagulation factor V activity\ndefinition : Any deviation from the activity of coagulation factor V.\nsynonyms :Abnormal factor V activity\n'}


{'id': 'HP_0031900', 'url': 'http://purl.obolibrary.org/obo/HP_0031900', 'lbl': 'obsolete Abnormal serum tryptase concentration', 'desc': 'label: obsolete Abnormal serum tryptase concentration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031901', 'url': 'http://purl.obolibrary.org/obo/HP_0031901', 'lbl': 'Elevated total serum tryptase', 'desc': 'label: Elevated total serum tryptase\ndefinition : An abnormally elevated concentration of total tryptase (alpha and beta tryptase) in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0031902', 'url': 'http://purl.obolibrary.org/obo/HP_0031902', 'lbl': 'obsolete Decreased serum mast cell beta-tryptase concentration', 'desc': 'label: obsolete Decreased serum mast cell beta-tryptase concentration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031903', 'url': 'http://purl.obolibrary.org/obo/HP_0031903', 'lbl': 'Abnormal circulating selenium concentration', 'desc': 'label: Abnormal circulating selenium concentration\ndefinition : Any deviation from the normal circulating concentration of selenium.\nsynonyms :Abnormal serum selenium concentration\n'}


{'id': 'HP_0031904', 'url': 'http://purl.obolibrary.org/obo/HP_0031904', 'lbl': 'Abnormal total hemolytic complement activity', 'desc': 'label: Abnormal total hemolytic complement activity\ndefinition : Any deviation from the normal total hemolytic complement activity in the circulation.\nsynonyms :Abnormal CH50\n'}


{'id': 'HP_0031905', 'url': 'http://purl.obolibrary.org/obo/HP_0031905', 'lbl': 'Increased total hemolytic complement activity', 'desc': 'label: Increased total hemolytic complement activity\ndefinition : An abnormally elevated total hemolytic complement activity in the circulation.\nsynonyms :\n'}


{'id': 'HP_0031906', 'url': 'http://purl.obolibrary.org/obo/HP_0031906', 'lbl': 'Decreased total hemolytic complement activity', 'desc': 'label: Decreased total hemolytic complement activity\ndefinition : An abnormally reduced total hemolytic complement activity in the circulation.\nsynonyms :\n'}


{'id': 'HP_0031907', 'url': 'http://purl.obolibrary.org/obo/HP_0031907', 'lbl': 'Anti-mitochondrial M2 antibody positivity', 'desc': 'label: Anti-mitochondrial M2 antibody positivity\ndefinition : The presence of M2 anti-mitochondrial antibody (immunoglobulins) in the serum.\nsynonyms :AMA-M2 positive; Anti-pyruvate dehydrogenase antibody positivity\n'}


{'id': 'HP_0031908', 'url': 'http://purl.obolibrary.org/obo/HP_0031908', 'lbl': 'Micrographia', 'desc': 'label: Micrographia\ndefinition : Abnormally small sized handwriting defined formally as an impairment of a fine motor skill manifesting mainly as a progressive or stable reduction in amplitude during a writing task.\nsynonyms :\n'}


{'id': 'HP_0031909', 'url': 'http://purl.obolibrary.org/obo/HP_0031909', 'lbl': 'Unicornuate uterus', 'desc': 'label: Unicornuate uterus\ndefinition : A uterus that has a single horn, with a banana-like shape that may or may not have a secondary rudimentary uterine horn.\nsynonyms :\n'}


{'id': 'HP_0031910', 'url': 'http://purl.obolibrary.org/obo/HP_0031910', 'lbl': 'Abnormal cranial nerve physiology', 'desc': 'label: Abnormal cranial nerve physiology\ndefinition : A functional abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem.\nsynonyms :\n'}


{'id': 'HP_0031911', 'url': 'http://purl.obolibrary.org/obo/HP_0031911', 'lbl': 'Abnormal fifth cranial nerve physiology', 'desc': 'label: Abnormal fifth cranial nerve physiology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031912', 'url': 'http://purl.obolibrary.org/obo/HP_0031912', 'lbl': 'Trigeminal anesthesia', 'desc': 'label: Trigeminal anesthesia\ndefinition : Decreased or absent sensation in the distribution of the trigeminal nerve, which provides tactile, proprioceptive, and nociceptive sensation in the area of the face and mouth.\nsynonyms :Trigeminal anaesthesia\n'}


{'id': 'HP_0031913', 'url': 'http://purl.obolibrary.org/obo/HP_0031913', 'lbl': 'Rhombencephalosynapsis', 'desc': 'label: Rhombencephalosynapsis\ndefinition : Rhombencephalosynapsis is a rare brain malformation defined by midline fusion of the cerebellar hemispheres with partial or complete loss of the intervening vermis.\nsynonyms :\n'}


{'id': 'HP_0031914', 'url': 'http://purl.obolibrary.org/obo/HP_0031914', 'lbl': 'Fluctuating', 'desc': 'label: Fluctuating\ndefinition : Varying irregularly over time in severity, amount, or amplitude.\nsynonyms :\n'}


{'id': 'HP_0031915', 'url': 'http://purl.obolibrary.org/obo/HP_0031915', 'lbl': 'Stable', 'desc': 'label: Stable\ndefinition : This modifier can be applied to a phenotypic feature that does not vary in severity or amount over time.\nsynonyms :\n'}


{'id': 'HP_0031917', 'url': 'http://purl.obolibrary.org/obo/HP_0031917', 'lbl': 'Digital ulcer', 'desc': 'label: Digital ulcer\ndefinition : An open sore on the surface of the skin of a finger or toe.\nsynonyms :\n'}


{'id': 'HP_0031918', 'url': 'http://purl.obolibrary.org/obo/HP_0031918', 'lbl': 'Ovarian sex cord-stromal tumor', 'desc': 'label: Ovarian sex cord-stromal tumor\ndefinition : A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts.\nsynonyms :Ovarian sex cord-stromal tumour\n'}


{'id': 'HP_0031919', 'url': 'http://purl.obolibrary.org/obo/HP_0031919', 'lbl': 'Juvenile type ovarian granulosa cell tumor', 'desc': 'label: Juvenile type ovarian granulosa cell tumor\ndefinition : Juvenile granulosa cell ovarian tumor (JGCOT) is a rare sex cord stromal tumor, occuring most frequently in premenarchal girls or young women. In contrast to adult granulosa cell tumor, JGCOT has a high mitotic index and more aggressive tumor growth. Microscopically it is seen as diffuse and regularly distributed neoplastic cells with a wide cytoplasm and pleomorphic hyperchromatic nucleus. Follicle formation, in various sizes and shapes, is important in JGCOT. Call-Exner bodies are infrequently seen in JGCOT in contrast to the adult type.\nsynonyms :Juvenile type ovarian granulosa cell tumour; Ovarian juvenile granulosa cell tumor; Ovarian juvenile granulosa cell tumour\n'}


{'id': 'HP_0031920', 'url': 'http://purl.obolibrary.org/obo/HP_0031920', 'lbl': 'Malignant ovarian granulosa cell tumor', 'desc': 'label: Malignant ovarian granulosa cell tumor\ndefinition : An aggressive granulosa cell tumor that arises from the ovary.\nsynonyms :Malignant ovarian granulosa cell tumour\n'}


{'id': 'HP_0031921', 'url': 'http://purl.obolibrary.org/obo/HP_0031921', 'lbl': 'Gastrocnemius myalgia', 'desc': 'label: Gastrocnemius myalgia\ndefinition : Pain of the gastrocnemius muscle.\nsynonyms :Calf muscle pain; Calf myalgia\n'}


{'id': 'HP_0031922', 'url': 'http://purl.obolibrary.org/obo/HP_0031922', 'lbl': 'Renal artery duplication', 'desc': 'label: Renal artery duplication\ndefinition : The renal arteries carry blood from the aorta to the kidney; normally one renal artery is present on each side of the body. Renal artery duplication refers to the presence of two rather than one renal artery on a given side of the body.\nsynonyms :Accessory renal artery; Double renal artery\n'}


{'id': 'HP_0031923', 'url': 'http://purl.obolibrary.org/obo/HP_0031923', 'lbl': 'Hematocolpos', 'desc': 'label: Hematocolpos\ndefinition : Accumulation of blood in the vagina usually due to vaginal obstruction.\nsynonyms :Haematocolpos\n'}


{'id': 'HP_0031924', 'url': 'http://purl.obolibrary.org/obo/HP_0031924', 'lbl': 'Rope sign', 'desc': 'label: Rope sign\ndefinition : The presence of linear erythematous palpable cords, often on the lateral trunk.\nsynonyms :\n'}


{'id': 'HP_0031925', 'url': 'http://purl.obolibrary.org/obo/HP_0031925', 'lbl': 'Rosette', 'desc': 'label: Rosette\ndefinition : A halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core; the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub.\nsynonyms :\n'}


{'id': 'HP_0031926', 'url': 'http://purl.obolibrary.org/obo/HP_0031926', 'lbl': 'Homer Wright rosette', 'desc': 'label: Homer Wright rosette\ndefinition : A type of rosette in which the central lumen or hub is filled with fiber-like processes.\nsynonyms :\n'}


{'id': 'HP_0031927', 'url': 'http://purl.obolibrary.org/obo/HP_0031927', 'lbl': 'Flexner-Wintersteiner rosette', 'desc': 'label: Flexner-Wintersteiner rosette\ndefinition : The tumor cells that form the Flexner-Wintersteiner rosette circumscribe a central lumen that contains small cytoplasmic extensions of the encircling cells; however, unlike the center of the Homer Wright rosette, the central lumen does not contain the fiber-rich neuropil.\nsynonyms :\n'}


{'id': 'HP_0031928', 'url': 'http://purl.obolibrary.org/obo/HP_0031928', 'lbl': 'True ependymal rosette', 'desc': 'label: True ependymal rosette\ndefinition : A type of rosette in which a halo of cells surrounds an empty lumen.\nsynonyms :\n'}


{'id': 'HP_0031929', 'url': 'http://purl.obolibrary.org/obo/HP_0031929', 'lbl': 'Perivascular pseudorosette', 'desc': 'label: Perivascular pseudorosette\ndefinition : A type of rosette in which a spoke-wheel arrangement of cells with tapered cellular processes radiates around a wall of a centrally placed vessel.\nsynonyms :\n'}


{'id': 'HP_0031930', 'url': 'http://purl.obolibrary.org/obo/HP_0031930', 'lbl': 'Neurocytic rosette', 'desc': 'label: Neurocytic rosette\ndefinition : A type of rosette that is similar to the Homer Wright rosette, but the central fiber-rich neuropil island is larger and more irregular.\nsynonyms :Pineocytomatous rosette\n'}


{'id': 'HP_0031931', 'url': 'http://purl.obolibrary.org/obo/HP_0031931', 'lbl': 'Ocular flutter', 'desc': 'label: Ocular flutter\ndefinition : Ocular flutter is an abnormal eye movement consisting of repetitive, irregular, involuntary bursts of horizontal saccades without an intersaccadic interval. It is generally superimposed on normal oculomotor behaviour and its occurrence may be favoured by various events, such as blinks, the triggering of normal saccades or optokinetic stimulation.\nsynonyms :\n'}


{'id': 'HP_0031932', 'url': 'http://purl.obolibrary.org/obo/HP_0031932', 'lbl': 'Aorto-left ventricular tunnel', 'desc': 'label: Aorto-left ventricular tunnel\ndefinition : Aorto-left ventricular tunnel (ALVT) is a congenital extracardiac channel connecting the ascending aorta above the sino-tubular junction to either left or right ventricular cavity.\nsynonyms :Left ventricle to aorta tunnel\n'}


{'id': 'HP_0031933', 'url': 'http://purl.obolibrary.org/obo/HP_0031933', 'lbl': 'Aorto-right ventricular tunnel', 'desc': 'label: Aorto-right ventricular tunnel\ndefinition : The presence of an extracardiac channel that connects the ascending aorta above the sinotubular junction to the cavity of the right ventricle.\nsynonyms :Right ventricle to aorta tunnel\n'}


{'id': 'HP_0031934', 'url': 'http://purl.obolibrary.org/obo/HP_0031934', 'lbl': 'Abnormal descending aorta morphology', 'desc': 'label: Abnormal descending aorta morphology\ndefinition : A structural abnormality of the part of the aorta that begins at the aortic arch and then descends through the chest and abdomen.\nsynonyms :\n'}


{'id': 'HP_0031935', 'url': 'http://purl.obolibrary.org/obo/HP_0031935', 'lbl': 'Ascending aorta hypoplasia', 'desc': 'label: Ascending aorta hypoplasia\ndefinition : Significant luminal narrowing of a long segment of or the entire ascending aorta.\nsynonyms :\n'}


{'id': 'HP_0031936', 'url': 'http://purl.obolibrary.org/obo/HP_0031936', 'lbl': 'Delayed ability to walk', 'desc': 'label: Delayed ability to walk\ndefinition : A failure to achieve the ability to walk at an appropriate developmental stage. Most children learn to walk in a series of stages, and learn to walk short distances independently between 12 and 15 months.\nsynonyms :Delayed walking\n'}


{'id': 'HP_0031937', 'url': 'http://purl.obolibrary.org/obo/HP_0031937', 'lbl': 'Tachylalia', 'desc': 'label: Tachylalia\ndefinition : Fast speech.\nsynonyms :Tachylogia\n'}


{'id': 'HP_0031938', 'url': 'http://purl.obolibrary.org/obo/HP_0031938', 'lbl': 'Abnormal conus terminalis morphology', 'desc': 'label: Abnormal conus terminalis morphology\ndefinition : Any structural anomaly of the conus terminalis, which is the distal bulbous part of the spinal cord at the location where the spinal cord tapers and ends (usually between the L1 and L2 lumbar vertebrae).\nsynonyms :Abnormal conus medullaris morphology\n'}


{'id': 'HP_0031939', 'url': 'http://purl.obolibrary.org/obo/HP_0031939', 'lbl': 'Conus terminalis arteriovenous malformation', 'desc': 'label: Conus terminalis arteriovenous malformation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031941', 'url': 'http://purl.obolibrary.org/obo/HP_0031941', 'lbl': 'Abnormal portal venous system morphology', 'desc': 'label: Abnormal portal venous system morphology\ndefinition : Any structural anomaly of the portal venous sytem, which comprises all of the veins draining the abdominal part of the digestive tract, including the lower esophagus but excluding the lower anal canal. The portal vein conveys blood from viscera and ramifies like an artery at the liver, ending at the sinusoids. Tributaries of the portal vein, which make up the portal venous system, are the splenic, superior mesenteric, left gastric, right gastric, paraumbilical, and cystic veins.\nsynonyms :\n'}


{'id': 'HP_0031942', 'url': 'http://purl.obolibrary.org/obo/HP_0031942', 'lbl': 'Congenital absence of portal vein', 'desc': 'label: Congenital absence of portal vein\ndefinition : Anomaly where the intestinal and the splenic venous drainage bypass the liver and drain into systemic veins through other possible venous shunts.\nsynonyms :CAPV; Missing portal vein\n'}


{'id': 'HP_0031943', 'url': 'http://purl.obolibrary.org/obo/HP_0031943', 'lbl': 'Akathisia', 'desc': 'label: Akathisia\ndefinition : A state of motor restlessness, usually in the lower extremities, that is often but not always accompanied by a subjective sense of inner restlessness, an urge to move, and anxiety or dysphoria.\nsynonyms :\n'}


{'id': 'HP_0031944', 'url': 'http://purl.obolibrary.org/obo/HP_0031944', 'lbl': 'Pleural thickening', 'desc': 'label: Pleural thickening\ndefinition : An increase in the thickness of the pleura, generally related to scarring of the pleural tissue.\nsynonyms :Pleural incrassation\n'}


{'id': 'HP_0031945', 'url': 'http://purl.obolibrary.org/obo/HP_0031945', 'lbl': 'Elevated circulating N,N-dimethylglycine concentration', 'desc': 'label: Elevated circulating N,N-dimethylglycine concentration\ndefinition : An increased concentration of N,N-dimethylglycine in the circulation.\nsynonyms :Elevated N,N-dimethylglycine level\n'}


{'id': 'HP_0031946', 'url': 'http://purl.obolibrary.org/obo/HP_0031946', 'lbl': 'Elevated urinary N,N-dimethylglycine level', 'desc': 'label: Elevated urinary N,N-dimethylglycine level\ndefinition : An increased concentration of N,N-dimethylglycine in the urine.\nsynonyms :\n'}


{'id': 'HP_0031947', 'url': 'http://purl.obolibrary.org/obo/HP_0031947', 'lbl': 'Tongue tremor', 'desc': 'label: Tongue tremor\ndefinition : An unintentional, oscillating to-and-fro muscle movement affecting the tongue.\nsynonyms :Jerky movements of the tongue\n'}


{'id': 'HP_0031948', 'url': 'http://purl.obolibrary.org/obo/HP_0031948', 'lbl': 'Snowball lesion of corpus callosum', 'desc': 'label: Snowball lesion of corpus callosum\ndefinition : Centrally located corpus callosum hyperintensities said to resemble snowballs upon magnetic resonance imaging (with T2 or Sagittal fluid attenuated inversion recovery [FLAIR] sequences). The central location in the callosum makes them pathognomonic for Susac syndrome.\nsynonyms :\n'}


{'id': 'HP_0031949', 'url': 'http://purl.obolibrary.org/obo/HP_0031949', 'lbl': 'Recurrent bacterial upper respiratory tract infections', 'desc': 'label: Recurrent bacterial upper respiratory tract infections\ndefinition : An increased susceptibility to bacterial upper respiratory tract infections as manifested by a history of recurrent bacterial upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis).\nsynonyms :Recurrent bacterial URI\n'}


{'id': 'HP_0031950', 'url': 'http://purl.obolibrary.org/obo/HP_0031950', 'lbl': 'Usual interstitial pneumonia', 'desc': 'label: Usual interstitial pneumonia\ndefinition : Temporal and spatial heterogeneity in lungs based on presence of fibrosis and honeycombing.\nsynonyms :\n'}


{'id': 'HP_0031951', 'url': 'http://purl.obolibrary.org/obo/HP_0031951', 'lbl': 'Nocturnal seizures', 'desc': 'label: Nocturnal seizures\ndefinition : Seizures that occur while the affected individual is sleeping.\nsynonyms :Sleep seizures\n'}


{'id': 'HP_0031952', 'url': 'http://purl.obolibrary.org/obo/HP_0031952', 'lbl': 'Neurogenic claudication', 'desc': 'label: Neurogenic claudication\ndefinition : Lumbar spinal stenoses may induce symptoms following an individually typical latency on standing or when walking due to swelling of the cauda equina, which leads to compression. This is referred to as neurogenic claudication. The symptoms of lumbar spinal stenosis can be explained by an increase in lumbar lordosis and spinal canal stenosis in an upright position compared to the sitting position or if spondylolisthesis is present by a shift of the vertebrae while standing and walking. Following an individually characteristic distance, walking becomes associated with deep muscular pain and with neurological deficits, such as sensory deficits and paresis in the lower limbs, which resolve within minutes when the affected person sits or lies down. Activities performed in a flexed posture, such as cycling often cause less problems than walking. For the same reason, walking uphill may be tolerated better than walking downhill. Clinical neurological examination at rest may be entirely normal but there is usually pain on hyperextension of the lumbar spine.\nsynonyms :\n'}


{'id': 'HP_0031953', 'url': 'http://purl.obolibrary.org/obo/HP_0031953', 'lbl': 'Cautious gait', 'desc': "label: Cautious gait\ndefinition : Cautious gait refers to an excessive degree of age-related changes in walking and fear of falling. The walking difficulties seem out of proportion when considering the patient's actual sensory or motor deficits. The gait appears slow, with a wider base than normal, reduced arm swing bilaterally and a slightly stooped posture. This type of gait change often occurs after the first time a patient has fallen.\nsynonyms :Senile gait\n"}


{'id': 'HP_0031954', 'url': 'http://purl.obolibrary.org/obo/HP_0031954', 'lbl': 'Dystonic gait', 'desc': 'label: Dystonic gait\ndefinition : Dystonic gait disorders frequently appear bizarre, particularly because activity increases dystonic tonus and posture. The abnormal posture of the foot in dystonic gait typically involves inversion, plantar flexion and tonic extension of the big toe. In many patients complex types of walking, such as walking backwards and running are paradoxically less impaired than walking forward and may seem completely unaffected. Sensory tricks, for instance, if the affected individual rests a hand on his or her neck, may improve or even normalize dystonic gait in some patients.\nsynonyms :\n'}


{'id': 'HP_0031955', 'url': 'http://purl.obolibrary.org/obo/HP_0031955', 'lbl': 'Antalgic gait', 'desc': 'label: Antalgic gait\ndefinition : To avoid pain weight is put on the affected leg for as short a time as possible, resulting in a limp. The patients appear to be walking as if there were a thorn in the sole of the foot. To reduce the load on the affected leg the patients lift and lower their foot in a fixed ankle position.\nsynonyms :Limp\n'}


{'id': 'HP_0031956', 'url': 'http://purl.obolibrary.org/obo/HP_0031956', 'lbl': 'Elevated circulating aspartate aminotransferase concentration', 'desc': 'label: Elevated circulating aspartate aminotransferase concentration\ndefinition : An abnormally high concentration in the circulation of aspartate aminotransferase (AST).\nsynonyms :Aspartate aminotransferase increased; Elevated serum AST; Elevated serum aspartate aminotransferase; Elevated serum glutamic oxaloacetic transaminase\n'}


{'id': 'HP_0031957', 'url': 'http://purl.obolibrary.org/obo/HP_0031957', 'lbl': 'Spastic hemiparetic gait', 'desc': 'label: Spastic hemiparetic gait\ndefinition : Spastic hemiparesis is characterized by a dominance of the tonus in the upper limb flexor muscles: the arm is held in an adducted posture and is bent and rotated inwards, the forearm is pronated and the hand and the fingers are flexed. The leg is slightly bent at the hip, the knee cannot be extended fully at the end of the stance phase and the foot is inverted and in a plantar flexed position. Gait is slow, with a wide base and asymmetrical with a shortened weight-bearing phase on the paretic side. During the swing phase, the paretic leg performs a lateral movement (circumduction) which is characteristic of this gait disorder, also termed Wernicke-Mann gait. Spastic gait problems typically worsen on attempts to walk faster.\nsynonyms :Wernicke-Mann gait\n'}


{'id': 'HP_0031958', 'url': 'http://purl.obolibrary.org/obo/HP_0031958', 'lbl': 'Spastic paraparetic gait', 'desc': 'label: Spastic paraparetic gait\ndefinition : A type of spastic gait in which the legs are usually slightly bent at the hip and in an adducted position. The knees are extended or slightly bent and the feet are in a plantar flexion position. This posture requires circumduction of the legs during walking. The gait may appear stiff (spastic gait disorder) or stiff as well as insecure (spastic ataxic gait disorder). In spastic paraparetic gait, each leg appears to be dragged forward. If the muscle tone in the adductors is marked, the resulting gait disorder is referred to as scissor gait.\nsynonyms :\n'}


{'id': 'HP_0031959', 'url': 'http://purl.obolibrary.org/obo/HP_0031959', 'lbl': 'Leg dystonia', 'desc': 'label: Leg dystonia\ndefinition : A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the legs.\nsynonyms :\n'}


{'id': 'HP_0031960', 'url': 'http://purl.obolibrary.org/obo/HP_0031960', 'lbl': 'Arm dystonia', 'desc': 'label: Arm dystonia\ndefinition : A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the arms.\nsynonyms :\n'}


{'id': 'HP_0031961', 'url': 'http://purl.obolibrary.org/obo/HP_0031961', 'lbl': 'Abnormal serum anion gap', 'desc': 'label: Abnormal serum anion gap\ndefinition : Any deviation from the normal value of the serum anion gap, which is calculated from the electrolytes measured in the chemical laboratory, is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration.\nsynonyms :\n'}


{'id': 'HP_0031962', 'url': 'http://purl.obolibrary.org/obo/HP_0031962', 'lbl': 'Elevated serum anion gap', 'desc': 'label: Elevated serum anion gap\ndefinition : An abnormally high value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration).\nsynonyms :\n'}


{'id': 'HP_0031963', 'url': 'http://purl.obolibrary.org/obo/HP_0031963', 'lbl': 'Decreased serum anion gap', 'desc': 'label: Decreased serum anion gap\ndefinition : An abnormally low value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration).\nsynonyms :\n'}


{'id': 'HP_0031964', 'url': 'http://purl.obolibrary.org/obo/HP_0031964', 'lbl': 'Elevated circulating alanine aminotransferase concentration', 'desc': 'label: Elevated circulating alanine aminotransferase concentration\ndefinition : An abnormally high concentration in the circulation of alanine aminotransferase (ALT).\nsynonyms :Alanine aminotransferase increased; Elevated serum ALT; Elevated serum alanine aminotransferase; Elevated serum glutamic-pyruvic transaminase\n'}


{'id': 'HP_0031965', 'url': 'http://purl.obolibrary.org/obo/HP_0031965', 'lbl': 'Increased RBC distribution width', 'desc': 'label: Increased RBC distribution width\ndefinition : Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage.\nsynonyms :Increased red blood cell distribution width\n'}


{'id': 'HP_0031967', 'url': 'http://purl.obolibrary.org/obo/HP_0031967', 'lbl': 'Cloudy urine', 'desc': 'label: Cloudy urine\ndefinition : The appearance of the urine having visible material in suspension, i.e., appearing cloudy.\nsynonyms :Turbid urine\n'}


{'id': 'HP_0031969', 'url': 'http://purl.obolibrary.org/obo/HP_0031969', 'lbl': 'Reduced blood urea nitrogen', 'desc': 'label: Reduced blood urea nitrogen\ndefinition : An abnormally low concentration of urea nitrogen in the blood.\nsynonyms :Reduced BUN\n'}


{'id': 'HP_0031970', 'url': 'http://purl.obolibrary.org/obo/HP_0031970', 'lbl': 'Abnormal blood urea nitrogen concentration', 'desc': 'label: Abnormal blood urea nitrogen concentration\ndefinition : Any deviation from the normal concentration of urea nitrogen in the blood.\nsynonyms :Abnormal BUN concentration\n'}


{'id': 'HP_0031971', 'url': 'http://purl.obolibrary.org/obo/HP_0031971', 'lbl': 'Subaortic ventricular septal bulge', 'desc': 'label: Subaortic ventricular septal bulge\ndefinition : A localized hypertrophy of the subaortic segment of the ventricular septum has been frequently described in elderly persons, and variously termed subaortic ventricular septal bulge (VSB), sigmoid-shaped septum, localized or discrete upper septal hypertrophy.\nsynonyms :\n'}


{'id': 'HP_0031972', 'url': 'http://purl.obolibrary.org/obo/HP_0031972', 'lbl': 'Presyncope', 'desc': 'label: Presyncope\ndefinition : Presyncope is a state of lightheadedness, muscular weakness, blurred vision, and feeling faint. Presyncope is most often cardiovascular in cause.\nsynonyms :\n'}


{'id': 'HP_0031973', 'url': 'http://purl.obolibrary.org/obo/HP_0031973', 'lbl': 'Increased vertical cup-to-disc ratio', 'desc': 'label: Increased vertical cup-to-disc ratio\ndefinition : An abnormal increase in the ratio of the height of the cup of the optic nerve head to the height of the disc.\nsynonyms :\n'}


{'id': 'HP_0031974', 'url': 'http://purl.obolibrary.org/obo/HP_0031974', 'lbl': 'Increased vertical cup-to-disc ratio - 0.6', 'desc': 'label: Increased vertical cup-to-disc ratio - 0.6\ndefinition : Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.6 (The normal cup-to-disc ratio is 0.3).\nsynonyms :\n'}


{'id': 'HP_0031975', 'url': 'http://purl.obolibrary.org/obo/HP_0031975', 'lbl': 'Increased vertical cup-to-disc ratio - 0.7', 'desc': 'label: Increased vertical cup-to-disc ratio - 0.7\ndefinition : Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.7 (The normal cup-to-disc ratio is 0.3).\nsynonyms :\n'}


{'id': 'HP_0031976', 'url': 'http://purl.obolibrary.org/obo/HP_0031976', 'lbl': 'Increased vertical cup-to-disc ratio - 0.8', 'desc': 'label: Increased vertical cup-to-disc ratio - 0.8\ndefinition : Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.8 (The normal cup-to-disc ratio is 0.3).\nsynonyms :\n'}


{'id': 'HP_0031977', 'url': 'http://purl.obolibrary.org/obo/HP_0031977', 'lbl': 'Increased vertical cup-to-disc ratio - 0.9', 'desc': 'label: Increased vertical cup-to-disc ratio - 0.9\ndefinition : Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.9 (The normal cup-to-disc ratio is 0.3).\nsynonyms :\n'}


{'id': 'HP_0031978', 'url': 'http://purl.obolibrary.org/obo/HP_0031978', 'lbl': 'Increased vertical cup-to-disc ratio - 1.0', 'desc': 'label: Increased vertical cup-to-disc ratio - 1.0\ndefinition : Ratio of the height of the cup of the optic nerve head to the height of the disc is 1.0 (The normal cup-to-disc ratio is 0.3).\nsynonyms :\n'}


{'id': 'HP_0031979', 'url': 'http://purl.obolibrary.org/obo/HP_0031979', 'lbl': 'Abnormal urine carbohydrate level', 'desc': 'label: Abnormal urine carbohydrate level\ndefinition : Any deviation from the normal concentration of a carbohydrate in the urine.\nsynonyms :\n'}


{'id': 'HP_0031980', 'url': 'http://purl.obolibrary.org/obo/HP_0031980', 'lbl': 'Abnormal urine carboxylic acid level', 'desc': 'label: Abnormal urine carboxylic acid level\ndefinition : Any deviation from the normal concentration of a carboxylic acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0031981', 'url': 'http://purl.obolibrary.org/obo/HP_0031981', 'lbl': 'Elevated urine glycolate', 'desc': 'label: Elevated urine glycolate\ndefinition : An increased concentration of glycolate in the urine.\nsynonyms :\n'}


{'id': 'HP_0031982', 'url': 'http://purl.obolibrary.org/obo/HP_0031982', 'lbl': 'Abnormal putamen morphology', 'desc': 'label: Abnormal putamen morphology\ndefinition : Any structural anomaly of the putamen, a brain nucleus which together with the caudate nucleus and fundus striati makes up the striatum.\nsynonyms :\n'}


{'id': 'HP_0031983', 'url': 'http://purl.obolibrary.org/obo/HP_0031983', 'lbl': 'Abnormal pulmonary thoracic imaging finding', 'desc': 'label: Abnormal pulmonary thoracic imaging finding\ndefinition : This term groups terms representing abnormal findings derived from chest X-ray investigation of the lung. In general, lung abnormalities can manifest as opacities (areas of increased density) or as regions with decreased density.\nsynonyms :Abnormal chest radiograph finding (lung)\n'}


{'id': 'HP_0031984', 'url': 'http://purl.obolibrary.org/obo/HP_0031984', 'lbl': 'Esophageal food impaction', 'desc': 'label: Esophageal food impaction\ndefinition : A piece of food that has gotten stuck in the esophagus and prevents further swallowing.\nsynonyms :\n'}


{'id': 'HP_0031985', 'url': 'http://purl.obolibrary.org/obo/HP_0031985', 'lbl': 'Esophageal exudate', 'desc': 'label: Esophageal exudate\ndefinition : An exudate is a mass of fluid and cells that has seeped out of blood vessels or an organ, usually related to inflammation. In the esophagus, exudates usually present as whitish plagues on the surface of the esophageal mucosa.\nsynonyms :\n'}


{'id': 'HP_0031986', 'url': 'http://purl.obolibrary.org/obo/HP_0031986', 'lbl': 'Polyminimyoclonus', 'desc': 'label: Polyminimyoclonus\ndefinition : Irregular, small-amplitude myoclonic movements of the hands and/or fingers on keeping outstretched posture (jerky postural tremor). Polyminimyoclonus is stimulus-sensitive and accentuated during voluntary movements. A cortical origin can be demonstrated by back-averaging techniques, and somatosensory evoked potentials (SSEPs) are sometimes giant.\nsynonyms :\n'}


{'id': 'HP_0031987', 'url': 'http://purl.obolibrary.org/obo/HP_0031987', 'lbl': 'Diminished ability to concentrate', 'desc': "label: Diminished ability to concentrate\ndefinition : Being unable to focus one's attention or mental effort on a particular object or activity.\nsynonyms :Concentration problems; Lack of concentration; Poor concentration\n"}


{'id': 'HP_0031988', 'url': 'http://purl.obolibrary.org/obo/HP_0031988', 'lbl': 'obsolete Muscle spasm', 'desc': 'label: obsolete Muscle spasm\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031989', 'url': 'http://purl.obolibrary.org/obo/HP_0031989', 'lbl': 'Perioral spasm', 'desc': 'label: Perioral spasm\ndefinition : A sudden involuntary contraction of the musculature surrounding the mouth.\nsynonyms :\n'}


{'id': 'HP_0031990', 'url': 'http://purl.obolibrary.org/obo/HP_0031990', 'lbl': 'Chvostek sign', 'desc': 'label: Chvostek sign\ndefinition : A contraction of ipsilateral facial muscles subsequent to percussion over the facial nerve.\nsynonyms :\n'}


{'id': 'HP_0031991', 'url': 'http://purl.obolibrary.org/obo/HP_0031991', 'lbl': 'Increased urinary excretion of galactosyl hydroxylysine', 'desc': 'label: Increased urinary excretion of galactosyl hydroxylysine\ndefinition : An increased concentration of beta-1-galactosyl-O-hydroxylysine (Gal-Hyl) in the urine. This is a biochemical marker of bone resorption.\nsynonyms :\n'}


{'id': 'HP_0031992', 'url': 'http://purl.obolibrary.org/obo/HP_0031992', 'lbl': 'Apical hypertrophic cardiomyopathy', 'desc': 'label: Apical hypertrophic cardiomyopathy\ndefinition : Apical hypertrophic cardiomyopathy (AHCM) is diastolic dysfunction due to abnormal stiffness of the left ventricle during diastole, with resultant impaired ventricular filling. In AHCM thickened apical segments produce a crowded, spade-shaped, small apical cavity.\nsynonyms :\n'}


{'id': 'HP_0031993', 'url': 'http://purl.obolibrary.org/obo/HP_0031993', 'lbl': 'Hoffmann sign', 'desc': "label: Hoffmann sign\ndefinition : A Hoffmann test is performed by flicking the fingernail of the long finger, from dorsal to volar, on each hand while the hand was supported by the examiner's hand. The test was done with the neck in the neutral position and then with the neck maximally forward flexed. Any flexion of the ipsilateral thumb and/or index finger was interpreted as a positive test.\nsynonyms :Hoffmann's sign\n"}


{'id': 'HP_0031994', 'url': 'http://purl.obolibrary.org/obo/HP_0031994', 'lbl': 'Bronchial breath sound', 'desc': 'label: Bronchial breath sound\ndefinition : Bronchial breath sounds contain much higher frequency components than normal breath sounds due to alteration of the low pass filtering function of the alveoli, as occurs in consolidation. It is loud, hollow, and high pitch. Expiratory phase is longer than inspiratory phase with the inspiratory-expiratory ratio (I:E) changing from normal 3:1 to 1:2. There is distinct pause between inspiration and expiration due to absent alveolar phase. It is associated with whispering pectoriloquy.\nsynonyms :\n'}


{'id': 'HP_0031995', 'url': 'http://purl.obolibrary.org/obo/HP_0031995', 'lbl': 'Squawks', 'desc': 'label: Squawks\ndefinition : Squawks are short inspiratory wheezes of less than 200 ms duration and are also known as squeaks. Acoustic analysis shows the fundamental frequency varying between 200 and 300 Hz. Squawks usually occur in late inspiration and are often preceded by late inspiratory crackles.\nsynonyms :\n'}


{'id': 'HP_0031996', 'url': 'http://purl.obolibrary.org/obo/HP_0031996', 'lbl': 'Inspiratory crackles', 'desc': 'label: Inspiratory crackles\ndefinition : Crackles that are heard during the inspiratory phase.\nsynonyms :\n'}


{'id': 'HP_0031997', 'url': 'http://purl.obolibrary.org/obo/HP_0031997', 'lbl': 'Early inspiratory crackles', 'desc': 'label: Early inspiratory crackles\ndefinition : Crackles that appear at the beginning of inspiration and end before mid-inspiration.\nsynonyms :\n'}


{'id': 'HP_0031998', 'url': 'http://purl.obolibrary.org/obo/HP_0031998', 'lbl': 'Late inspiratory crackles', 'desc': 'label: Late inspiratory crackles\ndefinition : Crackles that appear any time after the beginning of inspiration and last till the end of inspiration.\nsynonyms :\n'}


{'id': 'HP_0031999', 'url': 'http://purl.obolibrary.org/obo/HP_0031999', 'lbl': 'Expiratory crackles', 'desc': 'label: Expiratory crackles\ndefinition : Crackles that occur during expiration.\nsynonyms :\n'}


{'id': 'HP_0032000', 'url': 'http://purl.obolibrary.org/obo/HP_0032000', 'lbl': 'Pleural rub', 'desc': 'label: Pleural rub\ndefinition : An abnormal breath sound that is nonmusical, short and explosive. It is grating, rubbing, creaky, or leathery in character and present in both phases of respiration. Typically the expiratory component mirrors the inspiratory component. It occurs due to inflamed pleural surface rubbing each other during breathing. Clinically, it is important to differentiate it from crackles\nsynonyms :\n'}


{'id': 'HP_0032001', 'url': 'http://purl.obolibrary.org/obo/HP_0032001', 'lbl': 'Pink urine', 'desc': 'label: Pink urine\ndefinition : An abnormal pink color of urine.\nsynonyms :\n'}


{'id': 'HP_0032002', 'url': 'http://purl.obolibrary.org/obo/HP_0032002', 'lbl': 'Orange urine', 'desc': 'label: Orange urine\ndefinition : An abnormal orange color of urine.\nsynonyms :\n'}


{'id': 'HP_0032003', 'url': 'http://purl.obolibrary.org/obo/HP_0032003', 'lbl': 'Green urine', 'desc': 'label: Green urine\ndefinition : An abnormal green color of urine.\nsynonyms :\n'}


{'id': 'HP_0032004', 'url': 'http://purl.obolibrary.org/obo/HP_0032004', 'lbl': 'Pruritus vulvae', 'desc': 'label: Pruritus vulvae\ndefinition : A sensation of itching in the vulvar region.\nsynonyms :\n'}


{'id': 'HP_0032005', 'url': 'http://purl.obolibrary.org/obo/HP_0032005', 'lbl': 'Hemidystonia', 'desc': 'label: Hemidystonia\ndefinition : Hemidystonia refers to dystonia which involves the ipsilateral face, arm, and leg.\nsynonyms :\n'}


{'id': 'HP_0032006', 'url': 'http://purl.obolibrary.org/obo/HP_0032006', 'lbl': 'Lip tremor', 'desc': 'label: Lip tremor\ndefinition : An unintentional, oscillating to-and-fro muscle movement affecting the lip.\nsynonyms :\n'}


{'id': 'HP_0032007', 'url': 'http://purl.obolibrary.org/obo/HP_0032007', 'lbl': 'Maceration', 'desc': 'label: Maceration\ndefinition : A softening and breaking down of skin resulting from prolonged exposure to moisture. Macerated skin becomes soft and wrinkly and takes on a whitish hue.\nsynonyms :Maceration of the skin; Skin maceration\n'}


{'id': 'HP_0032008', 'url': 'http://purl.obolibrary.org/obo/HP_0032008', 'lbl': 'Pulmonary fat embolism', 'desc': 'label: Pulmonary fat embolism\ndefinition : The release of fat globules into the venous circulation, thereby blocking blood circulation to the lung.\nsynonyms :Fat embolism\n'}


{'id': 'HP_0032009', 'url': 'http://purl.obolibrary.org/obo/HP_0032009', 'lbl': 'Infantile constant exotropia', 'desc': 'label: Infantile constant exotropia\ndefinition : Constant exotropia occurring before 6 months of age.; often associated with a large angle of deviation and ocular/CNS abnormalities.\nsynonyms :Infantile (constant) exotropia\n'}


{'id': 'HP_0032010', 'url': 'http://purl.obolibrary.org/obo/HP_0032010', 'lbl': 'Basic constant exotropia', 'desc': 'label: Basic constant exotropia\ndefinition : Constant exotropia for near and distance, presenting after 6 months of age.\nsynonyms :Basic (constant) exotropia\n'}


{'id': 'HP_0032011', 'url': 'http://purl.obolibrary.org/obo/HP_0032011', 'lbl': 'Heterophoria', 'desc': 'label: Heterophoria\ndefinition : Heterophorias are latent deviations that are controlled by fusion. In certain circumstances (specific visual tasks, fatigue, illness, etc.), fusion can no longer be maintained and decompensation occurs.\nsynonyms :\n'}


{'id': 'HP_0032012', 'url': 'http://purl.obolibrary.org/obo/HP_0032012', 'lbl': 'Heterotropia', 'desc': 'label: Heterotropia\ndefinition : Manifest deviation of the visual axes not controlled by fusion.\nsynonyms :\n'}


{'id': 'HP_0032013', 'url': 'http://purl.obolibrary.org/obo/HP_0032013', 'lbl': 'Hypermetric horizontal saccades', 'desc': 'label: Hypermetric horizontal saccades\ndefinition : Overshoot of horizontal (sideways) saccadic eye movements.\nsynonyms :\n'}


{'id': 'HP_0032014', 'url': 'http://purl.obolibrary.org/obo/HP_0032014', 'lbl': 'Dysmetric vertical saccades', 'desc': 'label: Dysmetric vertical saccades\ndefinition : Inaccurate saccades (rapid movement of the eye between fixation points) in the vertical direction.\nsynonyms :\n'}


{'id': 'HP_0032015', 'url': 'http://purl.obolibrary.org/obo/HP_0032015', 'lbl': 'Dysmetric horizontal saccades', 'desc': 'label: Dysmetric horizontal saccades\ndefinition : Inaccurate saccades (rapid movement of the eye between fixation points) in the horizontal direction.\nsynonyms :\n'}


{'id': 'HP_0032016', 'url': 'http://purl.obolibrary.org/obo/HP_0032016', 'lbl': 'Abnormal sputum', 'desc': 'label: Abnormal sputum\ndefinition : Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin.\nsynonyms :Abnormal sputum morphology\n'}


{'id': 'HP_0032017', 'url': 'http://purl.obolibrary.org/obo/HP_0032017', 'lbl': 'Sputum eosinophilia', 'desc': 'label: Sputum eosinophilia\ndefinition : An increased proportion of eosinophils in sputum in the differentiated cell count.\nsynonyms :\n'}


{'id': 'HP_0032018', 'url': 'http://purl.obolibrary.org/obo/HP_0032018', 'lbl': 'Multiple mononeuropathy', 'desc': 'label: Multiple mononeuropathy\ndefinition : A type of peripheral neuropathy that happens when there is damage to two or more different nerve areas characterized by peripheral neuropathy of both the motor and sensory nerves of at least two different nerve trunks. Different nerves are affected either simultaneously or sequentially.\nsynonyms :Mononeuritis multiplex\n'}


{'id': 'HP_0032019', 'url': 'http://purl.obolibrary.org/obo/HP_0032019', 'lbl': 'Muscle eosinophilia', 'desc': 'label: Muscle eosinophilia\ndefinition : Eosinophil infiltration of skeletal muscle.\nsynonyms :Eosinophilic infiltration of skeletal muscle\n'}


{'id': 'HP_0032020', 'url': 'http://purl.obolibrary.org/obo/HP_0032020', 'lbl': 'Eosinophilic bladder infiltration', 'desc': 'label: Eosinophilic bladder infiltration\ndefinition : Transmural inflammation of the bladder predominantly with eosinophils, associated with fibrosis with or without muscle necrosis.\nsynonyms :Eosinophilic cystitis\n'}


{'id': 'HP_0032021', 'url': 'http://purl.obolibrary.org/obo/HP_0032021', 'lbl': 'Eosinophilic liver infiltration', 'desc': 'label: Eosinophilic liver infiltration\ndefinition : Cellular infiltration of the liver parenchyma with a preponderance of eosinophils.\nsynonyms :Eosinophilic hepatitis\n'}


{'id': 'HP_0032022', 'url': 'http://purl.obolibrary.org/obo/HP_0032022', 'lbl': 'Eosinophilic dermal infiltration', 'desc': 'label: Eosinophilic dermal infiltration\ndefinition : Presence of abnormally increased amounts of intraepidermal inflammatory cells with a predominance of eosinophils.\nsynonyms :Eosinophilic dermatitis\n'}


{'id': 'HP_0032023', 'url': 'http://purl.obolibrary.org/obo/HP_0032023', 'lbl': 'Eosinophilic gallbladder infiltration', 'desc': 'label: Eosinophilic gallbladder infiltration\ndefinition : Cellular infiltrate confirmed by a cellular infiltrate comprised of mainly eosinophils in the gallbladder wall on histological examination.\nsynonyms :Eosinophilic cholecystitis\n'}


{'id': 'HP_0032024', 'url': 'http://purl.obolibrary.org/obo/HP_0032024', 'lbl': 'Ileal ulcer', 'desc': 'label: Ileal ulcer\ndefinition : An erosion of the mucous membrane in a portion of the ileum.\nsynonyms :\n'}


{'id': 'HP_0032025', 'url': 'http://purl.obolibrary.org/obo/HP_0032025', 'lbl': 'Reduced serum alpha-1-antitrypsin', 'desc': 'label: Reduced serum alpha-1-antitrypsin\ndefinition : A reduced concentration of circulating alpha-1 antitrypsin, which is a 52-kDa glycoprotein mainly synthesised and secreted by hepatocytes into the bloodstream. Alpha-1 antitrypsin is a serine-proteinase inhibitor that it is crucial in maintaining protease-antiprotease homeostasis in the lungs.\nsynonyms :\n'}


{'id': 'HP_0032026', 'url': 'http://purl.obolibrary.org/obo/HP_0032026', 'lbl': 'Anetoderma', 'desc': 'label: Anetoderma\ndefinition : Circumscribed area of flaccid skin due to the loss of elastic tissue in the dermis.\nsynonyms :\n'}


{'id': 'HP_0032027', 'url': 'http://purl.obolibrary.org/obo/HP_0032027', 'lbl': 'Retinal dots', 'desc': 'label: Retinal dots\ndefinition : Yellow, white or greyish lesions in the retina that are well-defined/distinct, individual and mostly uniform in size.\nsynonyms :\n'}


{'id': 'HP_0032028', 'url': 'http://purl.obolibrary.org/obo/HP_0032028', 'lbl': 'Macular dots', 'desc': 'label: Macular dots\ndefinition : Yellow, white or greyish lesions in the macula that are well-defined/distinct, individual and mostly uniform in size.\nsynonyms :\n'}


{'id': 'HP_0032029', 'url': 'http://purl.obolibrary.org/obo/HP_0032029', 'lbl': 'Floppy eyelid', 'desc': 'label: Floppy eyelid\ndefinition : Excessive eyelid tissue laxity, typically affecting both upper eyelids and associated with spontanteous tarsal eversion during sleep. It is more common in the obese, it may be associated with obstructive sleep apnea and it may result in corneal exposure or chronic papillary conjunctivitis.\nsynonyms :\n'}


{'id': 'HP_0032030', 'url': 'http://purl.obolibrary.org/obo/HP_0032030', 'lbl': 'Lateral canthal tendon laxity', 'desc': 'label: Lateral canthal tendon laxity\ndefinition : Laxity of the tendon stabilising the lateral aspect of the tarsal plate to the zygomatic bone. This can result in rounded appearence of the lateral canthus. Also, when the eyelid is pulled medially, more than 2 mm movement of the canthal angle may be observed.\nsynonyms :\n'}


{'id': 'HP_0032031', 'url': 'http://purl.obolibrary.org/obo/HP_0032031', 'lbl': 'Medial canthal tendon laxity', 'desc': 'label: Medial canthal tendon laxity\ndefinition : Laxity of the tendon stabilising the medial aspect of the tarsal plate to the anterior and posterior lacrimal crests. This may lead to more than 2mm movement of the punctum when the eyelid is pulled laterally.\nsynonyms :\n'}


{'id': 'HP_0032032', 'url': 'http://purl.obolibrary.org/obo/HP_0032032', 'lbl': 'Horizontal eyelid laxity', 'desc': 'label: Horizontal eyelid laxity\ndefinition : Abnormally lax eyelid associated with tissue relaxation, predominantly in the horizontal plane. It can be demonstrated by the horizontal eyelid distraction test (e.g. by pulling the eyelid medially and laterally). Medial and/or lateral canthal tendon laxity are often present.\nsynonyms :\n'}


{'id': 'HP_0032033', 'url': 'http://purl.obolibrary.org/obo/HP_0032033', 'lbl': 'Vertical eyelid laxity', 'desc': 'label: Vertical eyelid laxity\ndefinition : Abnormally lax eyelid associated with tissue relaxation, predominantly in the vertical plane. It can be demonstrated by vertical lid pull. Loosening of vertical stabilising structures (e.g. lower lid retractors) or tarsal atrophy are often present.\nsynonyms :\n'}


{'id': 'HP_0032034', 'url': 'http://purl.obolibrary.org/obo/HP_0032034', 'lbl': 'Upper eyelid laxity', 'desc': 'label: Upper eyelid laxity\ndefinition : Abnormally lax upper eyelid associated with tissue relaxation.\nsynonyms :\n'}


{'id': 'HP_0032035', 'url': 'http://purl.obolibrary.org/obo/HP_0032035', 'lbl': 'Lower eyelid laxity', 'desc': 'label: Lower eyelid laxity\ndefinition : Abnormally lax lower eyelid associated with tissue relaxation.\nsynonyms :\n'}


{'id': 'HP_0032036', 'url': 'http://purl.obolibrary.org/obo/HP_0032036', 'lbl': 'Reduced contrast sensitivity', 'desc': 'label: Reduced contrast sensitivity\ndefinition : An abnormality in perception of contrast. Spatial contrast is a physical dimension referring to the light-dark transition of a border or an edge in an image that delineates the existence of a pattern or an object. Contrast sensitivity refers to a measure of how much contrast a person requires to see a target. Contrast-sensitivity measurements differ from acuity measurements; acuity is a measure of the spatial-resolving ability of the visual system under conditions of very high contrast, whereas contrast sensitivity is a measure of the threshold contrast for seeing a target.\nsynonyms :Abnormal contrast sensitivity\n'}


{'id': 'HP_0032037', 'url': 'http://purl.obolibrary.org/obo/HP_0032037', 'lbl': 'Mildly reduced visual acuity', 'desc': 'label: Mildly reduced visual acuity\ndefinition : Mild reduction of the ability to see defined as visual acuity less than 6/12 (20/40 in US notation; 0.5 in decimal notation) but at least 6/18 (20/63 in US notation; 0.32 in decimal notation).\nsynonyms :Mild reduction in visual acuity; Mild vision loss; Mild visual loss\n'}


{'id': 'HP_0032039', 'url': 'http://purl.obolibrary.org/obo/HP_0032039', 'lbl': 'Abnormality of the ocular adnexa', 'desc': 'label: Abnormality of the ocular adnexa\ndefinition : An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.\nsynonyms :\n'}


{'id': 'HP_0032040', 'url': 'http://purl.obolibrary.org/obo/HP_0032040', 'lbl': 'Abnormal ocular adnexa physiology', 'desc': 'label: Abnormal ocular adnexa physiology\ndefinition : A functional anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.\nsynonyms :\n'}


{'id': 'HP_0032041', 'url': 'http://purl.obolibrary.org/obo/HP_0032041', 'lbl': 'Vocal cord polyp', 'desc': 'label: Vocal cord polyp\ndefinition : A small growth on a vocal cord that may appear as pedunculated or sessile and have varying size, shape, and color.\nsynonyms :\n'}


{'id': 'HP_0032043', 'url': 'http://purl.obolibrary.org/obo/HP_0032043', 'lbl': 'Odynophagia', 'desc': 'label: Odynophagia\ndefinition : Pain experienced with swallowing.\nsynonyms :Painful swallowing\n'}


{'id': 'HP_0032044', 'url': 'http://purl.obolibrary.org/obo/HP_0032044', 'lbl': 'Decreased vigilance', 'desc': 'label: Decreased vigilance\ndefinition : A reduction in the ability to maintain sustained attention characterized by reduced alertness.\nsynonyms :\n'}


{'id': 'HP_0032045', 'url': 'http://purl.obolibrary.org/obo/HP_0032045', 'lbl': 'Hypoplastic carotid canal', 'desc': 'label: Hypoplastic carotid canal\ndefinition : Underdevelopment of the carotid canal, which normally is a circular aperture in the temporal bone of the skull through which the internal carotid artery and the carotid plexus of nerves traverse.\nsynonyms :\n'}


{'id': 'HP_0032046', 'url': 'http://purl.obolibrary.org/obo/HP_0032046', 'lbl': 'Focal cortical dysplasia', 'desc': 'label: Focal cortical dysplasia\ndefinition : A type of malformation of cortical development that primarily affects areas of neocortex. It can be identified on conventional magnetic resonance imaging as focal cortical thickening, abnormal gyration, and blurring between gray and white matter, often associated with clusters of heterotopic neurons.\nsynonyms :\n'}


{'id': 'HP_0032047', 'url': 'http://purl.obolibrary.org/obo/HP_0032047', 'lbl': 'Focal cortical dysplasia type I', 'desc': 'label: Focal cortical dysplasia type I\ndefinition : A type of focal cortical dysplasia that is characterized by abnormal cortical layering.\nsynonyms :\n'}


{'id': 'HP_0032048', 'url': 'http://purl.obolibrary.org/obo/HP_0032048', 'lbl': 'Focal cortical dysplasia type Ia', 'desc': 'label: Focal cortical dysplasia type Ia\ndefinition : A subtype of focal cortical dysplasia type I that is characterized by abnormal radial cortical lamination.\nsynonyms :\n'}


{'id': 'HP_0032049', 'url': 'http://purl.obolibrary.org/obo/HP_0032049', 'lbl': 'Focal cortical dysplasia type Ib', 'desc': 'label: Focal cortical dysplasia type Ib\ndefinition : A subtype of focal cortical dysplasia type I that is characterized by abnormal tangential cortical lamination.\nsynonyms :\n'}


{'id': 'HP_0032050', 'url': 'http://purl.obolibrary.org/obo/HP_0032050', 'lbl': 'Focal cortical dysplasia type Ic', 'desc': 'label: Focal cortical dysplasia type Ic\ndefinition : A subtype of focal cortical dysplasia type I that is characterized by abnormal radial and tangential cortical lamination.\nsynonyms :\n'}


{'id': 'HP_0032051', 'url': 'http://purl.obolibrary.org/obo/HP_0032051', 'lbl': 'Focal cortical dysplasia type II', 'desc': 'label: Focal cortical dysplasia type II\ndefinition : A type of focal cortical dysplasia that is characterized by disrupted cortical lamination and specific cytological abnormalities.\nsynonyms :\n'}


{'id': 'HP_0032052', 'url': 'http://purl.obolibrary.org/obo/HP_0032052', 'lbl': 'Focal cortical dysplasia type IIa', 'desc': 'label: Focal cortical dysplasia type IIa\ndefinition : A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons, which present with a significantly enlarged cell body and nucleus, malorientation, abnormally distributed intracellular Nissl substance and cytoplasmic accumulation of neurofilament proteins.\nsynonyms :\n'}


{'id': 'HP_0032053', 'url': 'http://purl.obolibrary.org/obo/HP_0032053', 'lbl': 'Focal cortical dysplasia type IIb', 'desc': 'label: Focal cortical dysplasia type IIb\ndefinition : A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons (significantly enlarged with accumulation of neurofilament proteins) and balloon cells.\nsynonyms :\n'}


{'id': 'HP_0032054', 'url': 'http://purl.obolibrary.org/obo/HP_0032054', 'lbl': 'Focal cortical dysplasia type III', 'desc': 'label: Focal cortical dysplasia type III\ndefinition : A type of focal cortical dysplasia that is characterized by cortical lamination abnormalities associated with a principal lesion, usually adjacent to or affecting the same cortical area/lobe.\nsynonyms :\n'}


{'id': 'HP_0032055', 'url': 'http://purl.obolibrary.org/obo/HP_0032055', 'lbl': 'Focal cortical dysplasia type IIIa', 'desc': "label: Focal cortical dysplasia type IIIa\ndefinition : A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural organisation (cortical dyslamination) or cytoarchitectural composition (hypertrophic neurons outside Layer 5) in patients with hippocampal sclerosis (also known as Ammon's horn sclerosis).\nsynonyms :\n"}


{'id': 'HP_0032056', 'url': 'http://purl.obolibrary.org/obo/HP_0032056', 'lbl': 'Focal cortical dysplasia type IIIb', 'desc': 'label: Focal cortical dysplasia type IIIb\ndefinition : A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) and/or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to glial or glioneuronal tumor.\nsynonyms :\n'}


{'id': 'HP_0032057', 'url': 'http://purl.obolibrary.org/obo/HP_0032057', 'lbl': 'Focal cortical dysplasia type IIIc', 'desc': 'label: Focal cortical dysplasia type IIIc\ndefinition : A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural (cortical dyslamination, hypoplasia) or cytoarchitectural composition of the neocortex (hypertrophic neurons), which occur adjacent to vascular malformations (cavernomas, arteriovenous malformations, leptomeningeal vascular malformations, telangiectasias, meningioangiomatosis).\nsynonyms :\n'}


{'id': 'HP_0032058', 'url': 'http://purl.obolibrary.org/obo/HP_0032058', 'lbl': 'Focal cortical dysplasia type IIId', 'desc': 'label: Focal cortical dysplasia type IIId\ndefinition : A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to other lesions acquired during early life (not included into FCD Type IIIa-c). These lesions comprise a large spectrum including traumatic brain injury, glial scarring after prenatal or perinatal ischemic injury or bleeding, and inflammatory or infectious diseases, i.e. Rasmussen encephalitis, limbic encephalitis, bacterial or viral infections.\nsynonyms :\n'}


{'id': 'HP_0032059', 'url': 'http://purl.obolibrary.org/obo/HP_0032059', 'lbl': 'Mild malformation of cortical development', 'desc': 'label: Mild malformation of cortical development\ndefinition : A malformation of cortical development characterized by mild abnormalities of the cortex: excessive heterotopic neurons in Layer 1 or microscopic neuronal clusters or excess of single neurons of normal morphology in deep white matter.\nsynonyms :\n'}


{'id': 'HP_0032060', 'url': 'http://purl.obolibrary.org/obo/HP_0032060', 'lbl': 'Epithelioid hemangioma', 'desc': 'label: Epithelioid hemangioma\ndefinition : A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area.\nsynonyms :Angiolymphoid hyperplasia with eosinophilia\n'}


{'id': 'HP_0032061', 'url': 'http://purl.obolibrary.org/obo/HP_0032061', 'lbl': 'Hypereosinophilia', 'desc': 'label: Hypereosinophilia\ndefinition : A severely increased count of eosinophils in the blood defined as a blood eosinophil count of at least 1.5 billion cells per liter.\nsynonyms :\n'}


{'id': 'HP_0032062', 'url': 'http://purl.obolibrary.org/obo/HP_0032062', 'lbl': 'Mallory-Weiss tear', 'desc': 'label: Mallory-Weiss tear\ndefinition : Vomiting-induced mucosal laceration at the esophago-gastric junction.\nsynonyms :\n'}


{'id': 'HP_0032063', 'url': 'http://purl.obolibrary.org/obo/HP_0032063', 'lbl': 'Ankle joint effusion', 'desc': 'label: Ankle joint effusion\ndefinition : Abnormal accumulation of fluid in or around the ankle joint.\nsynonyms :\n'}


{'id': 'HP_0032064', 'url': 'http://purl.obolibrary.org/obo/HP_0032064', 'lbl': 'Gastrointestinal eosinophilia', 'desc': 'label: Gastrointestinal eosinophilia\ndefinition : Eosinophilic infiltration of one or more gastrointestinal organs. Gastrointestinal eosinophilia is a broad term for abnormal eosinophil accumulation in the GI tract, involving many different disease identities. These diseases include primary eosinophil associated gastrointestinal diseases, gastrointestinal eosinophilia in HES and all gastrointestinal eosinophilic states associated with known causes. Each of these diseases has its unique features but there is no absolute boundary between them.\nsynonyms :Eosinophilic enteritis; Eosinophilic gastroenteritis; GI eosinophilia; Eosinophilic gastrointestinal disease; Eosinophilic gastrointestinal disorders\n'}


{'id': 'HP_0032065', 'url': 'http://purl.obolibrary.org/obo/HP_0032065', 'lbl': 'Abnormal serum bicarbonate concentration', 'desc': 'label: Abnormal serum bicarbonate concentration\ndefinition : Any deviation from the normal concentration of bicarbonate, HCO3[-], in the circulation.\nsynonyms :Abnormal serum HCO3 concentration\n'}


{'id': 'HP_0032066', 'url': 'http://purl.obolibrary.org/obo/HP_0032066', 'lbl': 'Decreased serum bicarbonate concentration', 'desc': 'label: Decreased serum bicarbonate concentration\ndefinition : An abnormal reduction of the concentration of bicarbonate, HCO3[-], in the circulation.\nsynonyms :Decreased serum HCO3 concentration\n'}


{'id': 'HP_0032067', 'url': 'http://purl.obolibrary.org/obo/HP_0032067', 'lbl': 'Elevated serum bicarbonate concentration', 'desc': 'label: Elevated serum bicarbonate concentration\ndefinition : An abnormal increase in the concentration of bicarbonate, HCO3[-], in the circulation.\nsynonyms :Elevated serum HCO3 concentration\n'}


{'id': 'HP_0032068', 'url': 'http://purl.obolibrary.org/obo/HP_0032068', 'lbl': 'Increased urinary mucus', 'desc': 'label: Increased urinary mucus\ndefinition : An increased amount of urinary mucus. A small amount of mucus is produced by mucous membrane epithelial cells of the urinary tract. An increased amount of mucus can be detected upon urinalysis or other assays and may indicate conditions such as urinary tract infection, urinary tract reconstruction involving the use of bowel segments, or contamination of the urine sample prior to urinalysis.\nsynonyms :\n'}


{'id': 'HP_0032069', 'url': 'http://purl.obolibrary.org/obo/HP_0032069', 'lbl': 'Anti-thyroglobulin antibody positivity', 'desc': 'label: Anti-thyroglobulin antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react to thyroglobulin.\nsynonyms :Anti-thyroid globulin antibody positivity; TgAbs\n'}


{'id': 'HP_0032070', 'url': 'http://purl.obolibrary.org/obo/HP_0032070', 'lbl': 'Leptomeningeal enhancement', 'desc': 'label: Leptomeningeal enhancement\ndefinition : Contrast material enhancement of the pia mater or enhancement that extends into the subarachnoid spaces of the sulci and cisterns is leptomeningeal enhancement. Leptomeningeal enhancement is usually associated with meningitis, which may be bacterial, viral, or fungal. The primary mechanism of this enhancement is breakdown of the blood-brain barrier without angiogenesis.\nsynonyms :\n'}


{'id': 'HP_0032071', 'url': 'http://purl.obolibrary.org/obo/HP_0032071', 'lbl': 'Eosinophilic pneumonia', 'desc': 'label: Eosinophilic pneumonia\ndefinition : The presence of eosinophils in lung tissue, generally as detected by tissue biopsy, with or without blood eosinophilia.\nsynonyms :Eosinophilic pulmonary infiltration; Pulmonary eosinophilic infiltrate; Pulmonary eosinophilic infiltration; Pulmonary eosinophilia\n'}


{'id': 'HP_0032072', 'url': 'http://purl.obolibrary.org/obo/HP_0032072', 'lbl': 'Popliteal synovial cyst', 'desc': "label: Popliteal synovial cyst\ndefinition : A fluid-filled mass that is a distention of a preexisting bursa in the popliteal fossa, most commonly the gastrocnemio-semimembranosus bursa. This bursa is unique in that it communicates with the knee joint, unlike other periarticular bursae, via an opening in the joint capsule posterior to the medial femoral condyle.\nsynonyms :Baker's cyst\n"}


{'id': 'HP_0032073', 'url': 'http://purl.obolibrary.org/obo/HP_0032073', 'lbl': 'Aplasia of the fallopian tube', 'desc': 'label: Aplasia of the fallopian tube\ndefinition : Aplasia, that is failure to develop, of the fallopian tube.\nsynonyms :\n'}


{'id': 'HP_0032075', 'url': 'http://purl.obolibrary.org/obo/HP_0032075', 'lbl': 'Splenopancreatic fusion', 'desc': 'label: Splenopancreatic fusion\ndefinition : Fusion of the pancreatic tail and spleen.\nsynonyms :\n'}


{'id': 'HP_0032076', 'url': 'http://purl.obolibrary.org/obo/HP_0032076', 'lbl': 'Abnormal male urethral meatus morphology', 'desc': 'label: Abnormal male urethral meatus morphology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032077', 'url': 'http://purl.obolibrary.org/obo/HP_0032077', 'lbl': 'Male urethral meatus stenosis', 'desc': 'label: Male urethral meatus stenosis\ndefinition : An abnormal narrowing of the urethral opening (meatus) of the penis.\nsynonyms :Meatal stenosis; Meatus stenosis\n'}


{'id': 'HP_0032078', 'url': 'http://purl.obolibrary.org/obo/HP_0032078', 'lbl': 'Angel-shaped phalanx', 'desc': 'label: Angel-shaped phalanx\ndefinition : A phalangeal malformation that is termed angel-shaped phalanx (ASP), because of its resemblance to the angels used for decoration of Christmas trees. The various components of an angel-shaped phalanx are: diaphyseal cuff (wings), surrounding a meta-diaphyseal core (body), which may appear empty or structured with a cone-shaped epiphysis (skirt) and pseudoepiphysis (head).\nsynonyms :\n'}


{'id': 'HP_0032079', 'url': 'http://purl.obolibrary.org/obo/HP_0032079', 'lbl': 'Medial degeneration', 'desc': 'label: Medial degeneration\ndefinition : Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections.\nsynonyms :\n'}


{'id': 'HP_0032081', 'url': 'http://purl.obolibrary.org/obo/HP_0032081', 'lbl': 'Intralamellar mucoid extracellular matrix accumulation', 'desc': 'label: Intralamellar mucoid extracellular matrix accumulation\ndefinition : A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix does not significantly alter the arrangement of the lamellar units.\nsynonyms :\n'}


{'id': 'HP_0032082', 'url': 'http://purl.obolibrary.org/obo/HP_0032082', 'lbl': 'Translamellar mucoid extracellular matrix accumulation', 'desc': 'label: Translamellar mucoid extracellular matrix accumulation\ndefinition : A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix alters the arrangement of the lamellar units to varying degrees.\nsynonyms :\n'}


{'id': 'HP_0032083', 'url': 'http://purl.obolibrary.org/obo/HP_0032083', 'lbl': 'Aortic elastic fiber fragmentation', 'desc': 'label: Aortic elastic fiber fragmentation\ndefinition : Loss and/or fragmentation of elastic fibers of the media of the aorta creating increasingly extended translamellar spaces, with absence of elastic fibers, and increased gaps in elastic fiber lamellae as identified on a stain for elastic fibers.\nsynonyms :Aortic elastic fibre fragmentation\n'}


{'id': 'HP_0032084', 'url': 'http://purl.obolibrary.org/obo/HP_0032084', 'lbl': 'Aortic elastic fiber thinning', 'desc': 'label: Aortic elastic fiber thinning\ndefinition : A thinning out of elastic fibers of the media of the aorta that creates widening of intralamellar spaces, as identified on a stain for elastic fibers.\nsynonyms :Aortic elastic fibre thinning\n'}


{'id': 'HP_0032085', 'url': 'http://purl.obolibrary.org/obo/HP_0032085', 'lbl': 'Aortic elastic fiber disorganization', 'desc': 'label: Aortic elastic fiber disorganization\ndefinition : Nonparallel arrangement/disarray of elastic fibers of the media of the aorta as identified on a stain for elastic fibers.\nsynonyms :Aortic elastic fibre disorganisation\n'}


{'id': 'HP_0032086', 'url': 'http://purl.obolibrary.org/obo/HP_0032086', 'lbl': 'Aortic smooth muscle cell nuclei loss', 'desc': 'label: Aortic smooth muscle cell nuclei loss\ndefinition : A region of the aortic media in which smooth muscle cell nuclei, involving multiple lamellae, are not clearly identifiable on an hematoxylin and eosin stain.\nsynonyms :\n'}


{'id': 'HP_0032087', 'url': 'http://purl.obolibrary.org/obo/HP_0032087', 'lbl': 'Aortic laminar medial collapse', 'desc': 'label: Aortic laminar medial collapse\ndefinition : Architecturally, a compaction of aortic medial elastic fibers that creates thinning of the lamellar unit secondary to a band-like smooth muscle cell loss identified using a stain for elastic fibers.\nsynonyms :\n'}


{'id': 'HP_0032088', 'url': 'http://purl.obolibrary.org/obo/HP_0032088', 'lbl': 'Aortic smooth muscle cell disorganization', 'desc': 'label: Aortic smooth muscle cell disorganization\ndefinition : Nonparallel arrangement/disarray of smooth muscle cells of the aortic media creating focal/multifocal disarray or sometimes nodular aggregates of smooth muscle cells.\nsynonyms :Aortic smooth muscle cell disorganisation\n'}


{'id': 'HP_0032089', 'url': 'http://purl.obolibrary.org/obo/HP_0032089', 'lbl': 'Aortic medial fibrosis', 'desc': 'label: Aortic medial fibrosis\ndefinition : An increase in collagen fibers creating areas of substitutive fibrosis or a widening of intralamellar spaces in the media of the aorta. This can be seen in conjunction with a loss to varying degrees of parallel arrangement of the elastic lamellae (or lamellar units).\nsynonyms :\n'}


{'id': 'HP_0032090', 'url': 'http://purl.obolibrary.org/obo/HP_0032090', 'lbl': 'Intralamellar aortic medial fibrosis', 'desc': 'label: Intralamellar aortic medial fibrosis\ndefinition : A type of aortic medial fibrosis in which the increase in collagen does not significantly alter the arrangement of the lamellar units.\nsynonyms :\n'}


{'id': 'HP_0032091', 'url': 'http://purl.obolibrary.org/obo/HP_0032091', 'lbl': 'Translamellar aortic medial fibrosis', 'desc': 'label: Translamellar aortic medial fibrosis\ndefinition : A type of aortic medial fibrosis in which the increase in collagen is more scar-like, altering the arrangement of the lamellar units.\nsynonyms :\n'}


{'id': 'HP_0032092', 'url': 'http://purl.obolibrary.org/obo/HP_0032092', 'lbl': 'Left ventricular outflow tract obstruction', 'desc': 'label: Left ventricular outflow tract obstruction\ndefinition : Left ventricular outflow tract (LVOT) obstruction can occur at the valvular, subvalvular, or supravalvular level. In general, there is an obstruction to forward flow which increases afterload, and if untreated, can result in hypertrophy, dilatation, and eventual failure of the left ventricle.\nsynonyms :\n'}


{'id': 'HP_0032094', 'url': 'http://purl.obolibrary.org/obo/HP_0032094', 'lbl': 'Increased circulating surfactant protein level', 'desc': 'label: Increased circulating surfactant protein level\ndefinition : An increased concentration of a surfactant protein in the blood circulation. Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions. These two proteins are detectable in the bloodstream and an elevated level may reflect idiopathic pulmonary fibrosis.\nsynonyms :Increased serum surfactant protein level\n'}


{'id': 'HP_0032096', 'url': 'http://purl.obolibrary.org/obo/HP_0032096', 'lbl': 'Abnormal manganese concentration', 'desc': 'label: Abnormal manganese concentration\ndefinition : A deviation from the normal range of manganese in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032097', 'url': 'http://purl.obolibrary.org/obo/HP_0032097', 'lbl': 'Hypermanganesemia', 'desc': 'label: Hypermanganesemia\ndefinition : An elevation above the normal concentration of manganese in the blood.\nsynonyms :Increased blood manganese concentration\n'}


{'id': 'HP_0032098', 'url': 'http://purl.obolibrary.org/obo/HP_0032098', 'lbl': 'Hypomanganesemia', 'desc': 'label: Hypomanganesemia\ndefinition : A reduction below the normal concentration of manganese in the blood.\nsynonyms :\n'}


{'id': 'HP_0032099', 'url': 'http://purl.obolibrary.org/obo/HP_0032099', 'lbl': 'Perioral radial furrowing', 'desc': 'label: Perioral radial furrowing\ndefinition : The presence of radial grooves in the skin surrounding the mouth (see Figure 4 of PMID:27833976).\nsynonyms :\n'}


{'id': 'HP_0032100', 'url': 'http://purl.obolibrary.org/obo/HP_0032100', 'lbl': "Abnormal doll's eye reflex", 'desc': "label: Abnormal doll's eye reflex\ndefinition : The doll's eye reflex (also known as oculocephalic reflex) is a test of brain function that is performed in comatose patients by elevating the head roughly 30 degrees and rapidly rotating the head from side to side with the eyes kept open. A normal response is for the eyes to move in the opposite direction. If the eyes do not move in the opposite direction this may indicate severe brain damage.\nsynonyms :\n"}


{'id': 'HP_0032101', 'url': 'http://purl.obolibrary.org/obo/HP_0032101', 'lbl': 'Unusual infection', 'desc': 'label: Unusual infection\ndefinition : A type of infection that is regarded as a sign of a pathological susceptibility to infection. There are five general subtypes. (i) Opportunistic infection, meaning infection by a pathogen that is not normally able to cause infection in a healthy host (e.g., pneumonia by Pneumocystis jirovecii or CMV); (ii) Unusual location (focus) of an infection (e.g., an aspergillus brain abscess); (iii) a protracted course or lack of adequate response to treatment (e.g., chronic rhinosinusitis); (iv) Unusual severity or intensity of an infection; and (v) unusual recurrence of infections.\nsynonyms :\n'}


{'id': 'HP_0032102', 'url': 'http://purl.obolibrary.org/obo/HP_0032102', 'lbl': 'Wilson sign', 'desc': "label: Wilson sign\ndefinition : Wilson sign is defined as the elicitation of pain by internally rotating the patient's tibia during knee extension between 90 degrees and 30 degrees of flexion and then relieving that pain by externally rotating the tibia.\nsynonyms :\n"}


{'id': 'HP_0032104', 'url': 'http://purl.obolibrary.org/obo/HP_0032104', 'lbl': 'Saccadic oscillation', 'desc': 'label: Saccadic oscillation\ndefinition : An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by an immediate corrective saccade.\nsynonyms :Saccadic oscillations\n'}


{'id': 'HP_0032105', 'url': 'http://purl.obolibrary.org/obo/HP_0032105', 'lbl': 'Macrosaccadic oscillations', 'desc': 'label: Macrosaccadic oscillations\ndefinition : A type of saccadic oscillations with brief periods of fixation between saccades (intersaccadic interval approximately 200 msec). Macrosaccadic oscillations (up to 40 degrees) straddle the intended fixation position and show a crescendo-decrescendo pattern.\nsynonyms :Macrosaccadic oscillation\n'}


{'id': 'HP_0032106', 'url': 'http://purl.obolibrary.org/obo/HP_0032106', 'lbl': 'Conjunctival icterus', 'desc': 'label: Conjunctival icterus\ndefinition : Conjunctival icterus is a condition where there is yellowing of the whites of the eyes. This is most commonly seen in patients who have liver disease.\nsynonyms :Scleral icterus; Yellow conjunctiva; Yellow sclera; Yellowing of the whites of the eyes\n'}


{'id': 'HP_0032107', 'url': 'http://purl.obolibrary.org/obo/HP_0032107', 'lbl': 'Limbal stem cell deficiency', 'desc': 'label: Limbal stem cell deficiency\ndefinition : A condition characterized by a loss or deficiency of the stem cells in the limbus that are vital for re-population of the corneal epithelium and to the barrier function of the limbus.\nsynonyms :\n'}


{'id': 'HP_0032108', 'url': 'http://purl.obolibrary.org/obo/HP_0032108', 'lbl': 'Mildly reduced contrast sensitivity', 'desc': 'label: Mildly reduced contrast sensitivity\ndefinition : A mild reduction in the ability to perceive visual contrast characterized by 0.20-0.59 log unit contrast sensitivity loss.\nsynonyms :Mild reduction in contrast sensitivity\n'}


{'id': 'HP_0032109', 'url': 'http://purl.obolibrary.org/obo/HP_0032109', 'lbl': 'Moderately reduced contrast sensitivity', 'desc': 'label: Moderately reduced contrast sensitivity\ndefinition : A moderate reduction in the ability to perceive visual contrast characterized by 0.60-0.99 log unit contrast sensitivity loss.\nsynonyms :Moderate reduction in contrast sensitivity\n'}


{'id': 'HP_0032110', 'url': 'http://purl.obolibrary.org/obo/HP_0032110', 'lbl': 'Severely reduced contrast sensitivity', 'desc': 'label: Severely reduced contrast sensitivity\ndefinition : A severe reduction in the ability to perceive visual contrast characterized by 1.00 log unit or more contrast sensitivity loss.\nsynonyms :\n'}