{'id': 'HP_0033165', 'url': 'http://purl.obolibrary.org/obo/HP_0033165', 'lbl': 'Necrotizing enterocolitis', 'desc': 'label: Necrotizing enterocolitis\ndefinition : Inflammation of the intestine leading to bacterial invasion causing cellular damage and death which causes necrosis of the colon and intestine.\nsynonyms :\n'}


{'id': 'HP_0033166', 'url': 'http://purl.obolibrary.org/obo/HP_0033166', 'lbl': 'Recurrent viral upper respiratory tract infections', 'desc': 'label: Recurrent viral upper respiratory tract infections\ndefinition : An increased susceptibility to viral upper respiratory tract infections as manifested by a history of recurrent viral upper respiratory tract infections (otitis, sinusitis, pharyngitis, tonsillitis).\nsynonyms :\n'}


{'id': 'HP_0033167', 'url': 'http://purl.obolibrary.org/obo/HP_0033167', 'lbl': 'Neutrophilic urticarial dermatosis', 'desc': 'label: Neutrophilic urticarial dermatosis\ndefinition : A neutrophilic interstitial, perivascular and/or perieccrine infiltrate with leukocytoclasia. Notably, leukocytoclastic vasculitis is not present.\nsynonyms :\n'}


{'id': 'HP_0033168', 'url': 'http://purl.obolibrary.org/obo/HP_0033168', 'lbl': 'Reduced mevalonate kinase activity', 'desc': 'label: Reduced mevalonate kinase activity\ndefinition : Abnormally reduced activity of mevalonate kinase, which is a key enzyme in the mevalonate biosynthetic pathway that leads to the synthesis of both cholesterol and nonsterol isoprenoids.\nsynonyms :\n'}


{'id': 'HP_0033169', 'url': 'http://purl.obolibrary.org/obo/HP_0033169', 'lbl': 'Reduced total lung capacity', 'desc': 'label: Reduced total lung capacity\ndefinition : Abnormally reduced volume of air in the lungs upon the maximum effort of inspiration.\nsynonyms :Reduced TLC\n'}


{'id': 'HP_0033170', 'url': 'http://purl.obolibrary.org/obo/HP_0033170', 'lbl': 'Abnormal skinfold thickness measurement', 'desc': 'label: Abnormal skinfold thickness measurement\ndefinition : Any deviation from the normal range of a skinfold thickness, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers.\nsynonyms :\n'}


{'id': 'HP_0033171', 'url': 'http://purl.obolibrary.org/obo/HP_0033171', 'lbl': 'Abnormal triceps skinfold thickness', 'desc': 'label: Abnormal triceps skinfold thickness\ndefinition : Any deviation from the normal range of the thickness of the tricpes skinfold, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers.\nsynonyms :\n'}


{'id': 'HP_0033172', 'url': 'http://purl.obolibrary.org/obo/HP_0033172', 'lbl': 'Increased triceps skinfold thickness', 'desc': 'label: Increased triceps skinfold thickness\ndefinition : Increased thickness of the triceps skinfold, which is measured halfway down the back of the upper arm is increased.\nsynonyms :\n'}


{'id': 'HP_0033173', 'url': 'http://purl.obolibrary.org/obo/HP_0033173', 'lbl': 'Milky appearance of bronchoalveolar lavage fluid', 'desc': 'label: Milky appearance of bronchoalveolar lavage fluid\ndefinition : Return of lavage fluid with a milky apperance due to the accumulation of a mixture of pulmonary surfactant, which is a lipoprotein complex, in the alveolar space.\nsynonyms :\n'}


{'id': 'HP_0033174', 'url': 'http://purl.obolibrary.org/obo/HP_0033174', 'lbl': 'Bloody bronchoalveolar lavage fluid', 'desc': 'label: Bloody bronchoalveolar lavage fluid\ndefinition : Return of lavage fluid characteristically has a bloody apperance in pulmonary alveolar hemorrhage. This is due to admixture of blood, which typically increases with each consecutive lavage portion. Microscopically erythrocytes can be seen. After 24 to 48 h macrophages contain phagocytosed erythrocytes, indicating previous bleeding.\nsynonyms :\n'}


{'id': 'HP_0033175', 'url': 'http://purl.obolibrary.org/obo/HP_0033175', 'lbl': 'Elevated circulating 5-oxoproline concentration', 'desc': 'label: Elevated circulating 5-oxoproline concentration\ndefinition : Concentration of L-pyroglutamic acid in the blood is above the upper limit of normal.\nsynonyms :Elevated circulating L-pyroglutamic acid concentration\n'}


{'id': 'HP_0033176', 'url': 'http://purl.obolibrary.org/obo/HP_0033176', 'lbl': 'Submandibular lymph node enlargement', 'desc': 'label: Submandibular lymph node enlargement\ndefinition : Increased size of the lymph nodes that are located beneath the mandible (lower jaw).\nsynonyms :Submandibular lymphadenopathy\n'}


{'id': 'HP_0033177', 'url': 'http://purl.obolibrary.org/obo/HP_0033177', 'lbl': 'Elevated circulating suberic acid concentration', 'desc': 'label: Elevated circulating suberic acid concentration\ndefinition : An increased concentration of suberic acid in the blood circulation. Suberic acid is an alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.\nsynonyms :\n'}


{'id': 'HP_0033178', 'url': 'http://purl.obolibrary.org/obo/HP_0033178', 'lbl': 'Increased circulating interleukin 8 concentration', 'desc': 'label: Increased circulating interleukin 8 concentration\ndefinition : An increased concentration of interleukin-8 in the circulation.\nsynonyms :Increased serum IL-8; Increased serum interleukin 8; Increased serum interleukin-8\n'}


{'id': 'HP_0033179', 'url': 'http://purl.obolibrary.org/obo/HP_0033179', 'lbl': 'Elevated circulating aconitic acid concentration', 'desc': 'label: Elevated circulating aconitic acid concentration\ndefinition : An increased concentration of aconitic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033180', 'url': 'http://purl.obolibrary.org/obo/HP_0033180', 'lbl': 'Torsion of appendix of testis', 'desc': 'label: Torsion of appendix of testis\ndefinition : The appendix testis or hydatid of Morgagni, is a vestigial remnant of the Müllerian duct located on the superior pole of the testicle between the testis and epididymis. Although this appendage has no vital function, it is present in 50% of males. Torsion of twisting of this vestigial remnant can be incredibly painful, but usually requires no medical intervention.\nsynonyms :Twisted vestigial remnant of the Muellerian duct\n'}


{'id': 'HP_0033181', 'url': 'http://purl.obolibrary.org/obo/HP_0033181', 'lbl': 'Spinal epidural abscess', 'desc': 'label: Spinal epidural abscess\ndefinition : Spinal epidural abscess (SEA) is caused by a suppurative infection in the epidural space. The mass effect of the abscess can compress and reduce blood flow to the spinal cord, conus medullaris, or cauda equina.\nsynonyms :A severe pyogenic infection of the epidural space\n'}


{'id': 'HP_0033182', 'url': 'http://purl.obolibrary.org/obo/HP_0033182', 'lbl': 'Increased circulating cathepsin D level', 'desc': 'label: Increased circulating cathepsin D level\ndefinition : An increase in concentration of cathepsin D in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033183', 'url': 'http://purl.obolibrary.org/obo/HP_0033183', 'lbl': 'Bilobed right lung', 'desc': 'label: Bilobed right lung\ndefinition : A developmental defect of pulmonary lobation characterized by the presence of only two lobes of the right lung.\nsynonyms :\n'}


{'id': 'HP_0033184', 'url': 'http://purl.obolibrary.org/obo/HP_0033184', 'lbl': 'Triggered by infection', 'desc': 'label: Triggered by infection\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033185', 'url': 'http://purl.obolibrary.org/obo/HP_0033185', 'lbl': 'Triggered by EBV infection', 'desc': 'label: Triggered by EBV infection\ndefinition : Applies to a sign or symptom that is provoked or brought about by infection by the Epstein-Barr virus.\nsynonyms :Triggered by Epstein Barr virus infection\n'}


{'id': 'HP_0033186', 'url': 'http://purl.obolibrary.org/obo/HP_0033186', 'lbl': 'Misalignment of the pulmonary veins', 'desc': 'label: Misalignment of the pulmonary veins\ndefinition : The term is commonly used to describe a putative abnormal location of pulmonary vein branches adjacent to pulmonary arteries within the same adventitial sheath. However, evidence has been provided that the vessels in question are not pulmonary veins, however represent dilated bronchial veins.\nsynonyms :\n'}


{'id': 'HP_0033187', 'url': 'http://purl.obolibrary.org/obo/HP_0033187', 'lbl': 'Hyperimidodipeptiduria', 'desc': 'label: Hyperimidodipeptiduria\ndefinition : Elevated levels of proline-containing dipeptides in urine.\nsynonyms :Imidodipeptiduria\n'}


{'id': 'HP_0033188', 'url': 'http://purl.obolibrary.org/obo/HP_0033188', 'lbl': 'Cystic acne', 'desc': 'label: Cystic acne\ndefinition : A severe type of acne characterized by the formation of cysts enclosing a mixture of keratin and sebum.\nsynonyms :\n'}


{'id': 'HP_0033189', 'url': 'http://purl.obolibrary.org/obo/HP_0033189', 'lbl': 'Radiculomegaly', 'desc': 'label: Radiculomegaly\ndefinition : Tooth root length more than 2 SD above mean, or subjectively apparently increased tooth root length.\nsynonyms :Long dental root; Rhizomegaly; Root gigantism\n'}


{'id': 'HP_0033190', 'url': 'http://purl.obolibrary.org/obo/HP_0033190', 'lbl': 'Hypertrichotic hyperpigmented patch', 'desc': 'label: Hypertrichotic hyperpigmented patch\ndefinition : A large nonpalpable spot of the skin over 1 cm in dimension with increased pigmentation and increased hair growth.\nsynonyms :Cutaneous hyperpigmentation with overlying hypertrichosis\n'}


{'id': 'HP_0033191', 'url': 'http://purl.obolibrary.org/obo/HP_0033191', 'lbl': 'Increased circulating selenium concentration', 'desc': 'label: Increased circulating selenium concentration\ndefinition : An increased concentration of selenium in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033192', 'url': 'http://purl.obolibrary.org/obo/HP_0033192', 'lbl': 'Decreased circulating selenium concentration', 'desc': 'label: Decreased circulating selenium concentration\ndefinition : An abnormally reduced concentration of selenium in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033193', 'url': 'http://purl.obolibrary.org/obo/HP_0033193', 'lbl': 'Ballooning hepatocyte degeneration', 'desc': 'label: Ballooning hepatocyte degeneration\ndefinition : Swelling of the hepatocyte, rounding of its contour, and alteration of the cytoplasm, which takes on a reticulated, rarified, or flocculant quality. The cytoplasm of the ballooned hepatocytes often contains clumps of eosinophilic ropey material known as Mallory-Denk bodies (MDBs) or Mallory hyaline, which is composed of hyperphosphorylated misfolded intermediate filaments, ubiquitin, and ubiquitin-binding protein P62.\nsynonyms :Ballooning degeneration of hepatocytes\n'}


{'id': 'HP_0033194', 'url': 'http://purl.obolibrary.org/obo/HP_0033194', 'lbl': 'Perioral erythema', 'desc': 'label: Perioral erythema\ndefinition : Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the mouth.\nsynonyms :\n'}


{'id': 'HP_0033195', 'url': 'http://purl.obolibrary.org/obo/HP_0033195', 'lbl': 'Perianal erythema', 'desc': 'label: Perianal erythema\ndefinition : Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the anus.\nsynonyms :\n'}


{'id': 'HP_0033196', 'url': 'http://purl.obolibrary.org/obo/HP_0033196', 'lbl': 'Portal inflammation', 'desc': 'label: Portal inflammation\ndefinition : Infiltration of portal fields by inflammatory cells.\nsynonyms :Hepatic portal inflammation\n'}


{'id': 'HP_0033197', 'url': 'http://purl.obolibrary.org/obo/HP_0033197', 'lbl': 'Hepatic lobular inflammation', 'desc': 'label: Hepatic lobular inflammation\ndefinition : Infiltration of inflammatory cells in lobules of the liver. A focus of lobular inflammation can be defined as two or more inflammatory cells (neutrophils, lymphocytes and other mononuclear cells, eosinophils and microgranulomas) within the lobule present within the sinusoids or surrounding injured hepatocytes (ballooned or apoptotic hepatocytes).\nsynonyms :\n'}


{'id': 'HP_0033198', 'url': 'http://purl.obolibrary.org/obo/HP_0033198', 'lbl': 'Triggered by viral infection', 'desc': 'label: Triggered by viral infection\ndefinition : Applies to a sign or symptom that is provoked or brought about by infection by a virus.\nsynonyms :\n'}


{'id': 'HP_0033199', 'url': 'http://purl.obolibrary.org/obo/HP_0033199', 'lbl': 'Increased circulating interleukin 10 concentration', 'desc': 'label: Increased circulating interleukin 10 concentration\ndefinition : An elevation of the concentration of interleukin 10 in the blood circulation.\nsynonyms :Increased serum interleukin 10\n'}


{'id': 'HP_0033200', 'url': 'http://purl.obolibrary.org/obo/HP_0033200', 'lbl': 'Triceps hyporeflexia', 'desc': 'label: Triceps hyporeflexia\ndefinition : Reduced intensity of the triceps tendon reflex.\nsynonyms :Hyporeflexia of triceps\n'}


{'id': 'HP_0033201', 'url': 'http://purl.obolibrary.org/obo/HP_0033201', 'lbl': 'Biceps hyporeflexia', 'desc': 'label: Biceps hyporeflexia\ndefinition : Reduced intensity of the biceps tendon reflex.\nsynonyms :Hyporeflexia of biceps\n'}


{'id': 'HP_0033202', 'url': 'http://purl.obolibrary.org/obo/HP_0033202', 'lbl': 'Brachioradialis hyporeflexia', 'desc': 'label: Brachioradialis hyporeflexia\ndefinition : Reduced intensity of the brachioradialis tendon reflex.\nsynonyms :\n'}


{'id': 'HP_0033203', 'url': 'http://purl.obolibrary.org/obo/HP_0033203', 'lbl': 'Brachioradialis hyperreflexia', 'desc': 'label: Brachioradialis hyperreflexia\ndefinition : Increased intensity of the brachioradialis reflex.\nsynonyms :\n'}


{'id': 'HP_0033204', 'url': 'http://purl.obolibrary.org/obo/HP_0033204', 'lbl': 'Triceps hyperreflexia', 'desc': 'label: Triceps hyperreflexia\ndefinition : Increased intensity of the triceps reflex.\nsynonyms :\n'}


{'id': 'HP_0033205', 'url': 'http://purl.obolibrary.org/obo/HP_0033205', 'lbl': 'Biceps hyperreflexia', 'desc': 'label: Biceps hyperreflexia\ndefinition : Increased intensity of the biceps reflex.\nsynonyms :\n'}


{'id': 'HP_0033206', 'url': 'http://purl.obolibrary.org/obo/HP_0033206', 'lbl': 'Hyperactive Achilles reflex', 'desc': 'label: Hyperactive Achilles reflex\ndefinition : Increased intensity of the Achilles reflex.\nsynonyms :Hyperactive ankle jerk reflex; Hyperactive ankle reflex\n'}


{'id': 'HP_0033207', 'url': 'http://purl.obolibrary.org/obo/HP_0033207', 'lbl': 'Increased proportion autoreactive unresponsive CD21-/low B cells', 'desc': 'label: Increased proportion autoreactive unresponsive CD21-/low B cells\ndefinition : Increased proportion relative to B-lymphocytes of a subset of B lymphocytes characterized by dim/low levels of CD21, i.e., CD21-/low, in flow cytometry, and additionally enriched in autoreactive clones as determined for instance by clonse showing rheumatoid factor (anti-IgG) reactivity and antibodies recognizing cytoplasmic and to a lesser extent nuclear structures.\nsynonyms :\n'}


{'id': 'HP_0033208', 'url': 'http://purl.obolibrary.org/obo/HP_0033208', 'lbl': 'Alveolar capillary dysplasia', 'desc': 'label: Alveolar capillary dysplasia\ndefinition : A developmental defect of the alveolar airspace during cananicular lung development characterized by a decreased number of pulmonary capillaries located away from the alveolar epithelium, thickened alveolar septae, media hypertrophy of small pulmonary arteries and muscularization of distal arterioles, and in some cases lymphangiectasis.\nsynonyms :\n'}


{'id': 'HP_0033209', 'url': 'http://purl.obolibrary.org/obo/HP_0033209', 'lbl': 'Acinar dysplasia', 'desc': 'label: Acinar dysplasia\ndefinition : Arrest of lung development in the pseudoglandular stage (weeks 8 to 16 of human gestation) resulting in small sized lungs, predominantly composed of bronchial and bronchiolar structures embedded in abundant loose mesenchyme that is poorly vascularized. Acinar structures are essentially absent, with no significant formation of saccules and no alveoli.\nsynonyms :\n'}


{'id': 'HP_0033210', 'url': 'http://purl.obolibrary.org/obo/HP_0033210', 'lbl': 'Congenital alveolar dysplasia', 'desc': 'label: Congenital alveolar dysplasia\ndefinition : Arrest of lung development in the cananicular stage (weeks 18 to 26 of human gestation) resulting in simplified acinar spaces, frequently with abundant intervening mesenchyme and no alveoli. In later arrest growth stages early saccular formations may be seen. May resemble the lobular maldevelopment often seen in alveolar capillary dysplasia/misaligment of the pulmonary veins without vein misalignment or marked hypertensive changes of the pulmonary arteries.\nsynonyms :\n'}


{'id': 'HP_0033211', 'url': 'http://purl.obolibrary.org/obo/HP_0033211', 'lbl': 'Decreased total iron binding capacity', 'desc': 'label: Decreased total iron binding capacity\ndefinition : A reduction in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity.\nsynonyms :\n'}


{'id': 'HP_0033212', 'url': 'http://purl.obolibrary.org/obo/HP_0033212', 'lbl': 'Abnormal total iron binding capacity', 'desc': 'label: Abnormal total iron binding capacity\ndefinition : Any deviation from the normal total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added.\nsynonyms :\n'}


{'id': 'HP_0033213', 'url': 'http://purl.obolibrary.org/obo/HP_0033213', 'lbl': 'Elevated urine suberic acid level', 'desc': 'label: Elevated urine suberic acid level\ndefinition : An increased in the level of suberic acid in the urine above the normal range. Suberic acid is an alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.\nsynonyms :Elevated urine octanedioic acid level\n'}


{'id': 'HP_0033214', 'url': 'http://purl.obolibrary.org/obo/HP_0033214', 'lbl': 'Recurrent viral pneumonia', 'desc': 'label: Recurrent viral pneumonia\ndefinition : Increased susceptibility to viral pneumonia, as manifested by recurrent episodes of viral pneumonias.\nsynonyms :\n'}


{'id': 'HP_0033215', 'url': 'http://purl.obolibrary.org/obo/HP_0033215', 'lbl': 'Obliterative abnormality of the renal glomerulus', 'desc': 'label: Obliterative abnormality of the renal glomerulus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033216', 'url': 'http://purl.obolibrary.org/obo/HP_0033216', 'lbl': 'Glomerular hyalinosis', 'desc': 'label: Glomerular hyalinosis\ndefinition : Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus. Distribution can include vascular pole, perihilar, tip or neither tip, perihilar or vascular.\nsynonyms :\n'}


{'id': 'HP_0033217', 'url': 'http://purl.obolibrary.org/obo/HP_0033217', 'lbl': 'Perihilar glomerular hyalinosis', 'desc': 'label: Perihilar glomerular hyalinosis\ndefinition : Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the vascular pole/perihilum.\nsynonyms :\n'}


{'id': 'HP_0033218', 'url': 'http://purl.obolibrary.org/obo/HP_0033218', 'lbl': 'Glomerular hyalinosis at the tubular pole', 'desc': 'label: Glomerular hyalinosis at the tubular pole\ndefinition : Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the tip/tubular pole.\nsynonyms :\n'}


{'id': 'HP_0033219', 'url': 'http://purl.obolibrary.org/obo/HP_0033219', 'lbl': 'Glomerular hyalinosis away from the vascular and tubular poles', 'desc': 'label: Glomerular hyalinosis away from the vascular and tubular poles\ndefinition : Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at neither tip nor perihilar/vascular poles. Both the vascular and the tubular pole are present in the glomerular cross section.\nsynonyms :\n'}


{'id': 'HP_0033220', 'url': 'http://purl.obolibrary.org/obo/HP_0033220', 'lbl': '2-ethylhydracylic aciduria', 'desc': 'label: 2-ethylhydracylic aciduria\ndefinition : An increased concentration of 2-ethylhydracylic acid in the urine.\nsynonyms :Elevated urinary 2-ethylhydracylic acid; Elevated urinary 2-methylbutyrylglycine\n'}


{'id': 'HP_0033221', 'url': 'http://purl.obolibrary.org/obo/HP_0033221', 'lbl': 'Increased CD4:CD8 ratio', 'desc': 'label: Increased CD4:CD8 ratio\ndefinition : An abnormal elevation of the relative proportion of CD4+ to CD8+ T cells.\nsynonyms :\n'}


{'id': 'HP_0033222', 'url': 'http://purl.obolibrary.org/obo/HP_0033222', 'lbl': 'Decreased CD4:CD8 ratio', 'desc': 'label: Decreased CD4:CD8 ratio\ndefinition : An abnormal reduction of the relative proportion of CD4+ to CD8+ T cells.\nsynonyms :Inverted CD4/CD8 ratio; Inverted CD4:CD8 ratio\n'}


{'id': 'HP_0033223', 'url': 'http://purl.obolibrary.org/obo/HP_0033223', 'lbl': 'Abnormal glomerular parietal epithelial cell morphology', 'desc': "label: Abnormal glomerular parietal epithelial cell morphology\ndefinition : Any structural abnormality of the parietal epithelial cells that line the inside of Bowman's capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells at the urinary pole and with the podocytes at the vascular pole.\nsynonyms :\n"}


{'id': 'HP_0033224', 'url': 'http://purl.obolibrary.org/obo/HP_0033224', 'lbl': 'Glomerular parietal epithelial cell hyperplasia', 'desc': "label: Glomerular parietal epithelial cell hyperplasia\ndefinition : Increased number of parietal epithelial cells lining Bowman's capsule. Hyperplasia leads to the cells being present in 2 or more layers, often with crowding and multilayering.\nsynonyms :Hyperplasia of the glomerular parietal epithelial cell\n"}


{'id': 'HP_0033225', 'url': 'http://purl.obolibrary.org/obo/HP_0033225', 'lbl': 'Glomerular parietal epithelial cell hypertrophy', 'desc': 'label: Glomerular parietal epithelial cell hypertrophy\ndefinition : An abnormality of the glomerular parietal epithelial cells characterized by (1) Increased parietal epithelial cell size, with or without cytoplasmic protein droplets; or (2) enlarged nuclei with prominent nucleoli. Both features can be present\nsynonyms :Hypertrophy of the glomerular parietal epithelial cell\n'}


{'id': 'HP_0033226', 'url': 'http://purl.obolibrary.org/obo/HP_0033226', 'lbl': 'Bowman capsular hyaline drops', 'desc': "label: Bowman capsular hyaline drops\ndefinition : An insudative accumulation of amorphous, eosinophilic, periodic acid-Schiff (PAS)-positive, silver-negative material protruding from Bowman's capsule into the urinary space. Although not always evident by light microscopy, this material is located between Bowman's capsule and the parietal epithelial cells, in some cases associated with newly formed matrix material.\nsynonyms :Capsular hyaline drops within Bowman's capsule\n"}


{'id': 'HP_0033227', 'url': 'http://purl.obolibrary.org/obo/HP_0033227', 'lbl': 'Glomerular synechial adhesion', 'desc': "label: Glomerular synechial adhesion\ndefinition : An area of basement membrane continuity between the glomerular tuft and Bowman's capsule, without intervening crescent and not adjacent to an area of segmental sclerosis.\nsynonyms :\n"}


{'id': 'HP_0033228', 'url': 'http://purl.obolibrary.org/obo/HP_0033228', 'lbl': 'Triceps areflexia', 'desc': 'label: Triceps areflexia\ndefinition : Inability to elicit triceps tendon reflex.\nsynonyms :Areflexia of triceps\n'}


{'id': 'HP_0033229', 'url': 'http://purl.obolibrary.org/obo/HP_0033229', 'lbl': 'Brachioradialis areflexia', 'desc': 'label: Brachioradialis areflexia\ndefinition : Inability to elicit brachioradialis tendon reflex.\nsynonyms :Areflexia of brachioradialis\n'}


{'id': 'HP_0033230', 'url': 'http://purl.obolibrary.org/obo/HP_0033230', 'lbl': 'Biceps areflexia', 'desc': 'label: Biceps areflexia\ndefinition : Inability to elicit biceps tendon reflex.\nsynonyms :Areflexia of biceps\n'}


{'id': 'HP_0033231', 'url': 'http://purl.obolibrary.org/obo/HP_0033231', 'lbl': 'Abnormal glomerular mesangial cellularity', 'desc': 'label: Abnormal glomerular mesangial cellularity\ndefinition : Abnormal number of its constituent cells of the mesangium of the glomerulus of the kidney.\nsynonyms :\n'}


{'id': 'HP_0033232', 'url': 'http://purl.obolibrary.org/obo/HP_0033232', 'lbl': 'Abnormal glomerular mesangial matrix morphology', 'desc': 'label: Abnormal glomerular mesangial matrix morphology\ndefinition : Any structural anomaly of the glomerular matrix. Mesangial cells generate and embed in their own extracellular matrix. The mesangial matrix is different in composition from the glomerular basement membrane. Its constituents are type IV collagen (but only the alpha1 and alpha2 chains); type V collagen; laminin A, B1, and B2; and considerable amounts of fibronectin, heparan sulfate and chondroitin sulfate proteoglycans, entactin, and nidogen. Furthermore, small amounts of the proteoglycans decorin and biglycan are found in the mesangial matrix.\nsynonyms :\n'}


{'id': 'HP_0033233', 'url': 'http://purl.obolibrary.org/obo/HP_0033233', 'lbl': 'Paramesangial deposits', 'desc': 'label: Paramesangial deposits\ndefinition : Mesangial immune deposit located adjacent to the paramesangial glomerular basement membrane.\nsynonyms :\n'}


{'id': 'HP_0033234', 'url': 'http://purl.obolibrary.org/obo/HP_0033234', 'lbl': 'Mesangial hyaline deposition', 'desc': 'label: Mesangial hyaline deposition\ndefinition : Extracellular mesangial accumulation of moderately electron-dense, generally homogenous, amorphous-appearing extracellular material.\nsynonyms :\n'}


{'id': 'HP_0033235', 'url': 'http://purl.obolibrary.org/obo/HP_0033235', 'lbl': 'Difficulty descending stairs', 'desc': 'label: Difficulty descending stairs\ndefinition : Reduced ability to desscend stairs.\nsynonyms :Difficulty walking down stairs\n'}


{'id': 'HP_0033236', 'url': 'http://purl.obolibrary.org/obo/HP_0033236', 'lbl': 'Cognitive fatigue', 'desc': 'label: Cognitive fatigue\ndefinition : A failure to sustain attention that requires self-motivation to optimize performance.\nsynonyms :Central fatigue\n'}


{'id': 'HP_0033237', 'url': 'http://purl.obolibrary.org/obo/HP_0033237', 'lbl': 'Visceral epithelial cell detachment', 'desc': "label: Visceral epithelial cell detachment\ndefinition : Detachment of visceral epithelial cells (podocytes) from underlying glomerular basement membrane with intervening new loose basement membrane material (pale on Hematoxylin and eosin, periodic acid-Shiff, trichrome, or silver stain) forming a so-called 'halo'.\nsynonyms :Detachment of visceral epithelial cells; Podocyte detachment\n"}


{'id': 'HP_0033238', 'url': 'http://purl.obolibrary.org/obo/HP_0033238', 'lbl': 'Podocyte microvillous transformation', 'desc': 'label: Podocyte microvillous transformation\ndefinition : Cytoplasmic projections into the urinary space from the luminal side of the podocyte.\nsynonyms :\n'}


{'id': 'HP_0033239', 'url': 'http://purl.obolibrary.org/obo/HP_0033239', 'lbl': 'Visceral epithelial cell capping', 'desc': 'label: Visceral epithelial cell capping\ndefinition : Layer of hypertrophied visceral epithelial cells overlying a sclerosed segment of the tuft of the glomerulus.\nsynonyms :Podocyte cap\n'}


{'id': 'HP_0033240', 'url': 'http://purl.obolibrary.org/obo/HP_0033240', 'lbl': 'Elevated RV/TLC ratio', 'desc': 'label: Elevated RV/TLC ratio\ndefinition : An increase in the ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and (3) body plethysmography. An elevated RV/TLC can be interpreted as a sign of air trapping and hyperinflation.\nsynonyms :Hyperinflation on pulmonary function test; Overinflation on pulmonary function test\n'}


{'id': 'HP_0033241', 'url': 'http://purl.obolibrary.org/obo/HP_0033241', 'lbl': 'Polyalveolar lobe', 'desc': 'label: Polyalveolar lobe\ndefinition : An elevation of the total count of alveoli as determined by microscopic point-counting of randomly taken lung sections, not secondary to abnormalities in number, size and structure of the airways. In polyaveolar lobe, the number of alveoli is generally increased three to fivefold.\nsynonyms :\n'}


{'id': 'HP_0033242', 'url': 'http://purl.obolibrary.org/obo/HP_0033242', 'lbl': 'Horseshoe lung', 'desc': 'label: Horseshoe lung\ndefinition : A horseshoe lung is an uncommon congenital abnormality caused by the partial fusion of the bases of both lungs behind the pericardial sac.\nsynonyms :\n'}


{'id': 'HP_0033243', 'url': 'http://purl.obolibrary.org/obo/HP_0033243', 'lbl': 'Pulmonary necrosis', 'desc': 'label: Pulmonary necrosis\ndefinition : Cellular death affecting one or more parts of the lung. Necrosis is caused by diverse external and internal factors which result in the unregulated digestion of cell components.\nsynonyms :\n'}


{'id': 'HP_0033244', 'url': 'http://purl.obolibrary.org/obo/HP_0033244', 'lbl': 'Glycogen accumulation in pulmonary interstitial cells', 'desc': 'label: Glycogen accumulation in pulmonary interstitial cells\ndefinition : Accumulation of immature interstitial cells containing abundant cytoplasmic glycogen defined by periodic acid-Schiff (PAS) positive cells.\nsynonyms :\n'}


{'id': 'HP_0033245', 'url': 'http://purl.obolibrary.org/obo/HP_0033245', 'lbl': 'Abnormal alveolar type II pneumocyte morphology', 'desc': 'label: Abnormal alveolar type II pneumocyte morphology\ndefinition : Any structural abnormality of alveolar type 2 (ATII) cells.\nsynonyms :Abnormal alveolar epithelial type II cell morphology; Abnormal pulmonary type II cell morphology; Abnormal type II pneumocyte morphology\n'}


{'id': 'HP_0033246', 'url': 'http://purl.obolibrary.org/obo/HP_0033246', 'lbl': 'Type II pneumocyte hypertrophy', 'desc': 'label: Type II pneumocyte hypertrophy\ndefinition : Increase in size of type II pneumocytes, characterized by qualitative morphologic alterations, including cuboidal shapes, increased nucleocytoplasmic ratio, enlarged nuclei, prominent nucleoli, and various alterations in their nuclear chromatin.\nsynonyms :Hypertrophic alveolar type II cells; Hypertrophic alveolar type II pneumocytes\n'}


{'id': 'HP_0033247', 'url': 'http://purl.obolibrary.org/obo/HP_0033247', 'lbl': 'Pulmonary amyloidosis', 'desc': 'label: Pulmonary amyloidosis\ndefinition : Extracellular deposition in lung tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding.\nsynonyms :\n'}


{'id': 'HP_0033248', 'url': 'http://purl.obolibrary.org/obo/HP_0033248', 'lbl': 'Multiple pulmonary interstitial hyalinized nodules', 'desc': 'label: Multiple pulmonary interstitial hyalinized nodules\ndefinition : Fibrosing nodules, consisting of either unilateral or bilateral central whorled deposits of lamellar collagen hyalin.\nsynonyms :\n'}


{'id': 'HP_0033249', 'url': 'http://purl.obolibrary.org/obo/HP_0033249', 'lbl': 'Focal substantia nigra T2 hyperintensity', 'desc': 'label: Focal substantia nigra T2 hyperintensity\ndefinition : Hyperintense lesion in the substantia nigra on magnetic resonance T2 imaging.\nsynonyms :Focal substantia nigra T2 hyperintense lesion\n'}


{'id': 'HP_0033250', 'url': 'http://purl.obolibrary.org/obo/HP_0033250', 'lbl': 'Nailfold capillary tortuosity', 'desc': 'label: Nailfold capillary tortuosity\ndefinition : An increased number of turns of the blood vessels of the nailfold with a charactereistic winded or twisted appearance of the blood vessels.\nsynonyms :\n'}


{'id': 'HP_0033251', 'url': 'http://purl.obolibrary.org/obo/HP_0033251', 'lbl': 'Elevated residual volume', 'desc': "label: Elevated residual volume\ndefinition : Increase in the amount of air remaining in a person's lungs after full exhalation.\nsynonyms :Elevated RV\n"}


{'id': 'HP_0033252', 'url': 'http://purl.obolibrary.org/obo/HP_0033252', 'lbl': 'Palmar hyperlinearity', 'desc': 'label: Palmar hyperlinearity\ndefinition : Exaggerated skin markings (dermatoglyphics) on the palms of the hand.\nsynonyms :\n'}


{'id': 'HP_0033253', 'url': 'http://purl.obolibrary.org/obo/HP_0033253', 'lbl': 'Reduced circulating interferon gamma concentration', 'desc': 'label: Reduced circulating interferon gamma concentration\ndefinition : A reduction in the concentration of interferon gamma measured in the blood circulation.\nsynonyms :Reduced circulating interferon gamma\n'}


{'id': 'HP_0033254', 'url': 'http://purl.obolibrary.org/obo/HP_0033254', 'lbl': 'Anorectal stricture', 'desc': 'label: Anorectal stricture\ndefinition : Narrowing of the anorectum associated with inflammation or scar tissue.\nsynonyms :Stricture of the anorectum\n'}


{'id': 'HP_0033255', 'url': 'http://purl.obolibrary.org/obo/HP_0033255', 'lbl': 'Congenital lobar overinflation', 'desc': 'label: Congenital lobar overinflation\ndefinition : A congenital malformation characterized by an overdistended segment of lung, affecting an party of a lobe or the entire one. It results in progressive overinflation of one or more lobes.\nsynonyms :Congenital lobar emphysema\n'}


{'id': 'HP_0033256', 'url': 'http://purl.obolibrary.org/obo/HP_0033256', 'lbl': 'Pancolitis', 'desc': 'label: Pancolitis\ndefinition : Inflammation of the entire colon.\nsynonyms :\n'}


{'id': 'HP_0033257', 'url': 'http://purl.obolibrary.org/obo/HP_0033257', 'lbl': 'Delayed ability to walk with support', 'desc': 'label: Delayed ability to walk with support\ndefinition : A failure to achieve the ability to walk with support (cruise) at an appropriate developmental stage.\nsynonyms :Delayed ability to cruise\n'}


{'id': 'HP_0033258', 'url': 'http://purl.obolibrary.org/obo/HP_0033258', 'lbl': 'Sudden unexpected death in epilepsy', 'desc': 'label: Sudden unexpected death in epilepsy\ndefinition : Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which postmortem examination has not revealed a cause of death.\nsynonyms :SUDEP\n'}


{'id': 'HP_0033259', 'url': 'http://purl.obolibrary.org/obo/HP_0033259', 'lbl': 'Non-motor seizure', 'desc': 'label: Non-motor seizure\ndefinition : A seizure with clinical manifestation but without motor signs (other than possible behavior arrest) as its initial clinical manifestation. The electrographic onset may be generalized, focal, or unknown.\nsynonyms :\n'}


{'id': 'HP_0033260', 'url': 'http://purl.obolibrary.org/obo/HP_0033260', 'lbl': 'Livedo racemosa', 'desc': 'label: Livedo racemosa\ndefinition : Livedo racemosa describes a reddish-blue mottling of the skin in an irregular, reticular pattern. It differs from the more common livedo reticularis by its shape. Livedo racemosa consists of broken circular segments resulting in a seemingly larger pattern, as opposed to the fine, regular, complete network of livedo reticularis. Livedo racemosa results from permanent impairment of peripheral blood flow and, unlike livedo reticularis, it persists on warming.\nsynonyms :\n'}


{'id': 'HP_0033261', 'url': 'http://purl.obolibrary.org/obo/HP_0033261', 'lbl': 'Renal artery aneurysm', 'desc': 'label: Renal artery aneurysm\ndefinition : Increase in diameter of a segment of the renal artery that can be defined as a focal, isolated dilatation of all three layers of the arterial wall over 1.5 times the diameter of the disease-free proximal adjacent arterial segment.\nsynonyms :\n'}


{'id': 'HP_0033262', 'url': 'http://purl.obolibrary.org/obo/HP_0033262', 'lbl': 'Transphyseal fracture of the distal humerus', 'desc': 'label: Transphyseal fracture of the distal humerus\ndefinition : A fracture through the distal humeral physis that separates the entire distal humeral epiphysis from the metaphysis.\nsynonyms :Transphyseal distal humerus fracture\n'}


{'id': 'HP_0033263', 'url': 'http://purl.obolibrary.org/obo/HP_0033263', 'lbl': 'Absent platelet dense granules', 'desc': 'label: Absent platelet dense granules\ndefinition : Lack of platelet dense granules, a type of platelet organelles.\nsynonyms :Absent platelet dense bodies\n'}


{'id': 'HP_0033264', 'url': 'http://purl.obolibrary.org/obo/HP_0033264', 'lbl': 'Enlarged platelet dense granules', 'desc': 'label: Enlarged platelet dense granules\ndefinition : Increased size of platelet dense granules.\nsynonyms :\n'}


{'id': 'HP_0033265', 'url': 'http://purl.obolibrary.org/obo/HP_0033265', 'lbl': 'Podocyte myelin figures', 'desc': 'label: Podocyte myelin figures\ndefinition : Lamellated intracytoplasmic lipid inclusions within podocytes.\nsynonyms :Podocyte myelin inclusions\n'}


{'id': 'HP_0033266', 'url': 'http://purl.obolibrary.org/obo/HP_0033266', 'lbl': 'Glomerular pseudocrescent', 'desc': "label: Glomerular pseudocrescent\ndefinition : Visceral epithelial cell hyperplasia with resulting cellular crowding of the the urinary space. In contrast with true crescents, these proliferations lack inflammatory cells and fibrin. The cells are typically plump (not spindle-shaped) and often vacuolated, and Bowman's capsule is usually intact.\nsynonyms :\n"}


{'id': 'HP_0033267', 'url': 'http://purl.obolibrary.org/obo/HP_0033267', 'lbl': 'Abnormal glomerular capillary lumen morphology', 'desc': 'label: Abnormal glomerular capillary lumen morphology\ndefinition : Abnormal structural characteristics of the interior space of the capillary of the renal glomerulus.\nsynonyms :\n'}


{'id': 'HP_0033268', 'url': 'http://purl.obolibrary.org/obo/HP_0033268', 'lbl': 'Deflation of the glomerular tuft', 'desc': 'label: Deflation of the glomerular tuft\ndefinition : Wrinkling and folding of the capillaries without epithelial cell (podocyte) hyperplasia (formerly called ischemic type of collapse) involving o 80% of the glomerular tuft. The wrinkling is generally made by small regular folds of the glomerular basement membrane.\nsynonyms :\n'}


{'id': 'HP_0033269', 'url': 'http://purl.obolibrary.org/obo/HP_0033269', 'lbl': 'Glomerular capillary collapse', 'desc': 'label: Glomerular capillary collapse\ndefinition : Collapse is generally accompanied by other descriptors such as hypertrophy and hyperplasia of overlying glomerular epithelial cells, halo, protein droplets in podocytes and glomerular parietal epithelial cells (PECs).\nsynonyms :Collapse of glomerular capillary walls\n'}


{'id': 'HP_0033270', 'url': 'http://purl.obolibrary.org/obo/HP_0033270', 'lbl': 'Glomerular capillary congestion', 'desc': 'label: Glomerular capillary congestion\ndefinition : Global distention of glomerular capillaries with intraluminal intact red blood cells.\nsynonyms :Glomerular congestion\n'}


{'id': 'HP_0033271', 'url': 'http://purl.obolibrary.org/obo/HP_0033271', 'lbl': 'Glomerular capillary microaneurysm', 'desc': 'label: Glomerular capillary microaneurysm\ndefinition : Glomerular capillary dilatation due to loosening/detachment of the glomerular basement membrane (GBM) from its anchoring points, usually in the context of mesangiolysis or nodular glomerulosclerosis.\nsynonyms :\n'}


{'id': 'HP_0033272', 'url': 'http://purl.obolibrary.org/obo/HP_0033272', 'lbl': 'Abnormal glomerular endothelial cell morphology', 'desc': 'label: Abnormal glomerular endothelial cell morphology\ndefinition : An abnormal structure of the glomerular endothelial cells, which are highly specialized cells with fenestrae and a charged luminal glycocalyx layer that contribute to the filtration barrier.\nsynonyms :\n'}


{'id': 'HP_0033273', 'url': 'http://purl.obolibrary.org/obo/HP_0033273', 'lbl': 'Loss of glomerular endothelial cell fenestration', 'desc': 'label: Loss of glomerular endothelial cell fenestration\ndefinition : Loss of round to oval discontinuities normally present in the glomerular capillary endothelial cell cytoplasm.\nsynonyms :\n'}


{'id': 'HP_0033274', 'url': 'http://purl.obolibrary.org/obo/HP_0033274', 'lbl': 'Glomerular endotheliosis', 'desc': 'label: Glomerular endotheliosis\ndefinition : Enlargement of glomerular endothelial cells by cytoplasmic swelling with resulting partial or complete occlusion of the lumen.\nsynonyms :\n'}


{'id': 'HP_0033275', 'url': 'http://purl.obolibrary.org/obo/HP_0033275', 'lbl': 'Glomerular endothelial tubuloreticular inclusion', 'desc': 'label: Glomerular endothelial tubuloreticular inclusion\ndefinition : Inter-anastomosing tubular structures located within cisternae of endoplasmic reticulum, most often within endothelial cells and associated with exposure to interferon.\nsynonyms :\n'}


{'id': 'HP_0033276', 'url': 'http://purl.obolibrary.org/obo/HP_0033276', 'lbl': 'obsolete Glomerular endocapillary hypercellularity', 'desc': 'label: obsolete Glomerular endocapillary hypercellularity\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033277', 'url': 'http://purl.obolibrary.org/obo/HP_0033277', 'lbl': 'Glomerular fibrinoid necrosis', 'desc': 'label: Glomerular fibrinoid necrosis\ndefinition : Fibrin associated with glomerular basement membrane disruption and/or lysis of the mesangial matrix; this lesion does not require the presence of karyorrhexis.\nsynonyms :\n'}


{'id': 'HP_0033278', 'url': 'http://purl.obolibrary.org/obo/HP_0033278', 'lbl': 'Reduced CD95-induced lymphocyte apoptosis', 'desc': 'label: Reduced CD95-induced lymphocyte apoptosis\ndefinition : Reduced amount of programmed cell death in peripheral blood lymphocytes following exposure to CD95 (APO-1/Fas), which is a member of the death receptor family, a subfamily of the TNF-R superfamily. Crosslinking of CD95 with its natural ligand CD95L (CD178) or with agonistic antibodies such as anti-APO-1 induces apoptosis in sensitive cells.\nsynonyms :\n'}


{'id': 'HP_0033279', 'url': 'http://purl.obolibrary.org/obo/HP_0033279', 'lbl': 'Enterocutaneous fistula', 'desc': 'label: Enterocutaneous fistula\ndefinition : An abnormal connection (fistula) between the intra-abdominal intestinal tract and the skin.\nsynonyms :\n'}


{'id': 'HP_0033280', 'url': 'http://purl.obolibrary.org/obo/HP_0033280', 'lbl': 'Paratracheal lymphadenopathy', 'desc': 'label: Paratracheal lymphadenopathy\ndefinition : Enlargement of lymph nodes surrounding the trachea.\nsynonyms :\n'}


{'id': 'HP_0033281', 'url': 'http://purl.obolibrary.org/obo/HP_0033281', 'lbl': 'Circulating nucleated red blood cells', 'desc': 'label: Circulating nucleated red blood cells\ndefinition : The presence of nucleated red blood cells in the peripheral blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033282', 'url': 'http://purl.obolibrary.org/obo/HP_0033282', 'lbl': 'Abnormal glomerular basement membrane morphology', 'desc': 'label: Abnormal glomerular basement membrane morphology\ndefinition : Any abnormal sttructure of the glomerular basement membrane.\nsynonyms :\n'}


{'id': 'HP_0033283', 'url': 'http://purl.obolibrary.org/obo/HP_0033283', 'lbl': 'Segmentally thickened glomerular basement membrane', 'desc': 'label: Segmentally thickened glomerular basement membrane\ndefinition : Prominent glomerular basement membrane (GBM) reflecting a segmental and increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals.\nsynonyms :\n'}


{'id': 'HP_0033284', 'url': 'http://purl.obolibrary.org/obo/HP_0033284', 'lbl': 'Diffusely thickened glomerular basement membrane', 'desc': 'label: Diffusely thickened glomerular basement membrane\ndefinition : Prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals.\nsynonyms :\n'}


{'id': 'HP_0033285', 'url': 'http://purl.obolibrary.org/obo/HP_0033285', 'lbl': 'Thickened glomerular basement membranes with no electron dense deposits', 'desc': 'label: Thickened glomerular basement membranes with no electron dense deposits\ndefinition : Prominent glomerular basement membrane (GBM) reflecting an increase in thickness (subjective estimate) with no evidence of electron dense deposits by electron microscopy.\nsynonyms :\n'}


{'id': 'HP_0033286', 'url': 'http://purl.obolibrary.org/obo/HP_0033286', 'lbl': 'Thickened glomerular basement membranes with electron dense deposits', 'desc': 'label: Thickened glomerular basement membranes with electron dense deposits\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033287', 'url': 'http://purl.obolibrary.org/obo/HP_0033287', 'lbl': 'Glomerular basement membrane lucencies', 'desc': 'label: Glomerular basement membrane lucencies\ndefinition : Lucent zones within the glomerular basement membranes. May reflect remote/resolved deposits.\nsynonyms :\n'}


{'id': 'HP_0033288', 'url': 'http://purl.obolibrary.org/obo/HP_0033288', 'lbl': 'Glomerular basement membrane spikes', 'desc': 'label: Glomerular basement membrane spikes\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033289', 'url': 'http://purl.obolibrary.org/obo/HP_0033289', 'lbl': 'Glomerular basement membrane wrinkling', 'desc': 'label: Glomerular basement membrane wrinkling\ndefinition : Irregular folding of the glomerular basement membrane with an intact lamina densa.\nsynonyms :\n'}


{'id': 'HP_0033290', 'url': 'http://purl.obolibrary.org/obo/HP_0033290', 'lbl': 'Glomerular subendothelial widening', 'desc': 'label: Glomerular subendothelial widening\ndefinition : Expansion of the space between the glomerular endothelium and lamina densa by electron-lucent material.\nsynonyms :\n'}


{'id': 'HP_0033291', 'url': 'http://purl.obolibrary.org/obo/HP_0033291', 'lbl': 'Glomerular karyhorrhectic debris', 'desc': 'label: Glomerular karyhorrhectic debris\ndefinition : Apoptotic, pyknotic, and fragmented nuclei within the glomerulus.\nsynonyms :\n'}


{'id': 'HP_0033292', 'url': 'http://purl.obolibrary.org/obo/HP_0033292', 'lbl': 'Glomerular fibrin thrombus', 'desc': 'label: Glomerular fibrin thrombus\ndefinition : An aggregate of coagulated blood containing fibrin, with or without entrapped cellular elements, within a glomerular capillary lumen.\nsynonyms :\n'}


{'id': 'HP_0033293', 'url': 'http://purl.obolibrary.org/obo/HP_0033293', 'lbl': 'Glomerular hyaline pseudothrombus', 'desc': 'label: Glomerular hyaline pseudothrombus\ndefinition : Intracapillary amorphous, eosinophilic material consisting of immune deposits.\nsynonyms :\n'}


{'id': 'HP_0033294', 'url': 'http://purl.obolibrary.org/obo/HP_0033294', 'lbl': 'Glomerular lipoprotein thrombus', 'desc': 'label: Glomerular lipoprotein thrombus\ndefinition : Intracapillary silver-positive material that is finely vacuolated and laminated, and stains with oil red O on frozen sections.\nsynonyms :\n'}


{'id': 'HP_0033295', 'url': 'http://purl.obolibrary.org/obo/HP_0033295', 'lbl': 'Mesangial Immune complex deposition', 'desc': 'label: Mesangial Immune complex deposition\ndefinition : Extracellular meangial accumulation of finely granular material corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry; most typically electron-dense although this may decrease with resorption of the deposit.\nsynonyms :\n'}


{'id': 'HP_0033296', 'url': 'http://purl.obolibrary.org/obo/HP_0033296', 'lbl': 'Binucleated visceral epithelial cells', 'desc': 'label: Binucleated visceral epithelial cells\ndefinition : Visceral epithelial cells with 2 nuclei. Can be observed on light or ultrastructral microscopy.\nsynonyms :Binucleated podocytes\n'}


{'id': 'HP_0033297', 'url': 'http://purl.obolibrary.org/obo/HP_0033297', 'lbl': 'Multinucleated visceral epithelial cells', 'desc': 'label: Multinucleated visceral epithelial cells\ndefinition : Visceral epithelial cells with more than two nuclei. Can be observed on light or ultrastructral microscopy.\nsynonyms :Multinucleated podocytes; Podocyte multinucleation\n'}


{'id': 'HP_0033298', 'url': 'http://purl.obolibrary.org/obo/HP_0033298', 'lbl': 'Abnormal circulating complement factor H related protein 1 concentration', 'desc': 'label: Abnormal circulating complement factor H related protein 1 concentration\ndefinition : A deviation from the normal concentration in blood of factor H-related protein 1 (FHR-1)\nsynonyms :\n'}


{'id': 'HP_0033299', 'url': 'http://purl.obolibrary.org/obo/HP_0033299', 'lbl': 'Reduced circulating complement factor H related protein 1 concentration', 'desc': 'label: Reduced circulating complement factor H related protein 1 concentration\ndefinition : Decreased level of circulating complement factor H related protein 1 concentration in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033300', 'url': 'http://purl.obolibrary.org/obo/HP_0033300', 'lbl': 'Increased circulating complement factor H related protein 1 concentration', 'desc': 'label: Increased circulating complement factor H related protein 1 concentration\ndefinition : Elevated level of circulating complement factor H related protein 1 concentration in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033301', 'url': 'http://purl.obolibrary.org/obo/HP_0033301', 'lbl': 'Elevated circulating 1-methylhistidine concentration', 'desc': 'label: Elevated circulating 1-methylhistidine concentration\ndefinition : An abnormally increased level of 1-methylhistidine in the blood circulation. 1-methylhistidine is a derivative of L-histidine.\nsynonyms :\n'}


{'id': 'HP_0033302', 'url': 'http://purl.obolibrary.org/obo/HP_0033302', 'lbl': 'Elevated circulating 4-hydroxyphenylacetic acid concentration', 'desc': 'label: Elevated circulating 4-hydroxyphenylacetic acid concentration\ndefinition : An abnormally increased concentration of 4-Hydroxyphenylacetic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033303', 'url': 'http://purl.obolibrary.org/obo/HP_0033303', 'lbl': 'Elevated urinary monocarboxylic acid level', 'desc': 'label: Elevated urinary monocarboxylic acid level\ndefinition : Abnormally increased amount of a monocarboxylic acid in the urine. Monocarboxylic acids are molecules with one COOH functional group.\nsynonyms :\n'}


{'id': 'HP_0033304', 'url': 'http://purl.obolibrary.org/obo/HP_0033304', 'lbl': 'obsolete Elevated urine 4-hydroxyphenylacetic acid level', 'desc': 'label: obsolete Elevated urine 4-hydroxyphenylacetic acid level\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033305', 'url': 'http://purl.obolibrary.org/obo/HP_0033305', 'lbl': 'Abnormal circulating fetuin A concentration', 'desc': 'label: Abnormal circulating fetuin A concentration\ndefinition : Any deviation from the normal concentration of fetuin A in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033306', 'url': 'http://purl.obolibrary.org/obo/HP_0033306', 'lbl': 'Decreased circulating fetuin A concentration', 'desc': 'label: Decreased circulating fetuin A concentration\ndefinition : A reduction below normal of fetuin A in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033307', 'url': 'http://purl.obolibrary.org/obo/HP_0033307', 'lbl': 'Increased circulating fetuin A concentration', 'desc': 'label: Increased circulating fetuin A concentration\ndefinition : An elevation above normal of fetuin A in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033308', 'url': 'http://purl.obolibrary.org/obo/HP_0033308', 'lbl': 'Patellar overgrowth', 'desc': 'label: Patellar overgrowth\ndefinition : Excessive growth of the kneecap (patella).\nsynonyms :\n'}


{'id': 'HP_0033309', 'url': 'http://purl.obolibrary.org/obo/HP_0033309', 'lbl': 'Ileoileal intussusception', 'desc': 'label: Ileoileal intussusception\ndefinition : A type of intussusception of the small intestine in which one part of the ileum invaginates (telescopes) into another part of the ileum.\nsynonyms :\n'}


{'id': 'HP_0033310', 'url': 'http://purl.obolibrary.org/obo/HP_0033310', 'lbl': 'Osmotic diarrhea', 'desc': 'label: Osmotic diarrhea\ndefinition : Osmotic diarrhea results from the presence of osmotically active, poorly absorbed solutes in the bowel lumen that inhibit normal water and electrolyte absorption.\nsynonyms :\n'}


{'id': 'HP_0033311', 'url': 'http://purl.obolibrary.org/obo/HP_0033311', 'lbl': 'Abdominal aortic dissection', 'desc': 'label: Abdominal aortic dissection\ndefinition : A tear in the intimal layer of the abdominal aorta causing a separation between the intima and the medial layers.\nsynonyms :\n'}


{'id': 'HP_0033312', 'url': 'http://purl.obolibrary.org/obo/HP_0033312', 'lbl': 'Abnormal Bowman space morphology', 'desc': "label: Abnormal Bowman space morphology\ndefinition : Structural anomaly located in Bowman's space, which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron.\nsynonyms :\n"}


{'id': 'HP_0033313', 'url': 'http://purl.obolibrary.org/obo/HP_0033313', 'lbl': 'Urinary space collagenization', 'desc': "label: Urinary space collagenization\ndefinition : Acellular collagenous matrix within Bowman's space, not associated with extracapillary hypercellularity or necrosis, associated with sclerosis or deflation of the tuft.\nsynonyms :Collagenization of the urinary space\n"}


{'id': 'HP_0033314', 'url': 'http://purl.obolibrary.org/obo/HP_0033314', 'lbl': 'Visceral epithelial cell hyperplasia', 'desc': 'label: Visceral epithelial cell hyperplasia\ndefinition : Increased number of visceral epithelial cells (2 or more layers), often with crowding and multilayering, but without continuity with the parietal epithelium.\nsynonyms :Hyperplasia of visceral epithelial cells; Podocyte hyperplasia\n'}


{'id': 'HP_0033315', 'url': 'http://purl.obolibrary.org/obo/HP_0033315', 'lbl': 'Visceral epithelial hyaline droplets', 'desc': 'label: Visceral epithelial hyaline droplets\ndefinition : Round to ovoid, Periodic acid-Schiff (PAS)-positive, fuchsinophilic cytoplasmic inclusions within visceral epithelial cells.\nsynonyms :\n'}


{'id': 'HP_0033316', 'url': 'http://purl.obolibrary.org/obo/HP_0033316', 'lbl': 'Glomerular crescent formation', 'desc': "label: Glomerular crescent formation\ndefinition : Glomerular crescent refers hyperplastic lesions involving 10% or more of the circumference of Bowman's capsule. Crescents can be composed of a variable mixture of epithelial/leukocyte hypercellularity, fibrous matrix, and fibrin.\nsynonyms :\n"}


{'id': 'HP_0033317', 'url': 'http://purl.obolibrary.org/obo/HP_0033317', 'lbl': 'Cellular crescent', 'desc': 'label: Cellular crescent\ndefinition : A type of glomerular crescent characterized by extracapillary hypercellularity of greater than two cell layers and involving more than 10% of the capsular circumference, composed of greater than 75% cells with or without fibrin, and less than 25% fibrous matrix.\nsynonyms :\n'}


{'id': 'HP_0033318', 'url': 'http://purl.obolibrary.org/obo/HP_0033318', 'lbl': 'Fibrocellular crescent', 'desc': 'label: Fibrocellular crescent\ndefinition : A type of glomerular crescent characterized by extracapillary hypercellularity of more than 2 cell layers and involving over 10% of the capsular circumference, composed of 25% to 75% cells with or without fibrin, and the remainder fibrous matrix.\nsynonyms :\n'}


{'id': 'HP_0033319', 'url': 'http://purl.obolibrary.org/obo/HP_0033319', 'lbl': 'Fibrous crescent', 'desc': "label: Fibrous crescent\ndefinition : A type of glomerular crescent characterized by extracapillary fibrosis composed of greater than 75% matrix and of less than 25% cells with or without fibrin, usually associated with disruption of Bowman's capsule and involving over 10% of the capsular circumference.\nsynonyms :\n"}


{'id': 'HP_0033320', 'url': 'http://purl.obolibrary.org/obo/HP_0033320', 'lbl': 'Mesangial cell loss', 'desc': 'label: Mesangial cell loss\ndefinition : Loss of mesangial cells segmentally or globally.\nsynonyms :\n'}


{'id': 'HP_0033321', 'url': 'http://purl.obolibrary.org/obo/HP_0033321', 'lbl': 'Glomerular obsolescence', 'desc': "label: Glomerular obsolescence\ndefinition : Globally sclerotic glomeruli are that are small and without hyalinosis and may appear with collapse of the tuft with collagenization of the urinary space. Bowman's capsule is completely or partially absent and there is no periglomerular fibrosis and glomerular size is decreased by more than 50% compared to all other glomeruli in the same biopsy. Obsolescent glomeruli may appear to be receding into the interstitium.\nsynonyms :\n"}


{'id': 'HP_0033322', 'url': 'http://purl.obolibrary.org/obo/HP_0033322', 'lbl': 'Glomerular capillary wall duplication without cellular interposition', 'desc': 'label: Glomerular capillary wall duplication without cellular interposition\ndefinition : Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix, with or without endocapillary hypercellularity and no evidence of interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM.\nsynonyms :\n'}


{'id': 'HP_0033323', 'url': 'http://purl.obolibrary.org/obo/HP_0033323', 'lbl': 'Glomerular capillary wall duplication with cellular interposition', 'desc': 'label: Glomerular capillary wall duplication with cellular interposition\ndefinition : Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix with interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM.\nsynonyms :\n'}


{'id': 'HP_0033324', 'url': 'http://purl.obolibrary.org/obo/HP_0033324', 'lbl': 'Elevated circulating homovanillic acid concentration', 'desc': 'label: Elevated circulating homovanillic acid concentration\ndefinition : Increased concentration of homovanillic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033325', 'url': 'http://purl.obolibrary.org/obo/HP_0033325', 'lbl': 'Elevated circulating sebacic acid concentration', 'desc': 'label: Elevated circulating sebacic acid concentration\ndefinition : Increased concentration of sebacic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033326', 'url': 'http://purl.obolibrary.org/obo/HP_0033326', 'lbl': 'Elevated circulating hydroxyphenlyllactic acid concentration', 'desc': 'label: Elevated circulating hydroxyphenlyllactic acid concentration\ndefinition : An increased concentration of 4-hydroxyphenlyllactic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033327', 'url': 'http://purl.obolibrary.org/obo/HP_0033327', 'lbl': 'Nail psoriasis', 'desc': 'label: Nail psoriasis\ndefinition : Psoriatic nail abnormality characterized by the presence of neutrophils in the nail bed epithelium, hyperkeratosis with parakeratosis, presence of exudates on the corneal epithelium, focal hypogranulosis and psoriasiform hyperplasia of the nail bed.\nsynonyms :\n'}


{'id': 'HP_0033328', 'url': 'http://purl.obolibrary.org/obo/HP_0033328', 'lbl': 'Type II pneumocyte hyperplasia', 'desc': 'label: Type II pneumocyte hyperplasia\ndefinition : Increase in the number of type II pneumocytes.\nsynonyms :\n'}


{'id': 'HP_0033329', 'url': 'http://purl.obolibrary.org/obo/HP_0033329', 'lbl': 'Abnormal postural reflex', 'desc': "label: Abnormal postural reflex\ndefinition : Anomaly of the physiological response to maintain the body's posture when movement and position is altered.\nsynonyms :Abnormal postural reaction\n"}


{'id': 'HP_0033330', 'url': 'http://purl.obolibrary.org/obo/HP_0033330', 'lbl': 'Impaired neck-righting reflex', 'desc': 'label: Impaired neck-righting reflex\ndefinition : Abnormal neck-righting response, which is said to be a physiological response when a child is placed flat on his or her back and the head is turned 90 degrees to the right or the left. With a normal neck-righting response, there follows a reflected torsion of the vertebral column in the same direction as the induced rotation of the neck. That is, the whole body follows the direction in which the head was turned. The response is present from birth to the age of five years.\nsynonyms :\n'}


{'id': 'HP_0033331', 'url': 'http://purl.obolibrary.org/obo/HP_0033331', 'lbl': 'Acute phase response', 'desc': 'label: Acute phase response\ndefinition : Presence of one or more manifestations of the acute phase response. Acute phase proteins (APP) are blood proteins primarily synthesized by hepatocytes as part of the acute phase response (APR). The APR is part of the early-defense or innate immune system, which is triggered by different stimuli including trauma, infection, stress, neoplasia, and inflammation. The APR results in a complex systemic reaction with the goal of reestablishing homeostasis and promoting healing.\nsynonyms :\n'}


{'id': 'HP_0033332', 'url': 'http://purl.obolibrary.org/obo/HP_0033332', 'lbl': 'Elevated circulating amyloid A', 'desc': 'label: Elevated circulating amyloid A\ndefinition : An increased concentration of serum amyloid A in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033333', 'url': 'http://purl.obolibrary.org/obo/HP_0033333', 'lbl': 'Jaw contracture', 'desc': 'label: Jaw contracture\ndefinition : Limitation of motion of the jaw due to structural changes in a muscle such as the massseter responsible for jaw movement.\nsynonyms :\n'}


{'id': 'HP_0033334', 'url': 'http://purl.obolibrary.org/obo/HP_0033334', 'lbl': 'Abnormal embryonic development', 'desc': 'label: Abnormal embryonic development\ndefinition : An anomaly in the development of the embryo, that is, of the early developmental stage of development that follows the fertilization of an egg by sperm.\nsynonyms :\n'}


{'id': 'HP_0033335', 'url': 'http://purl.obolibrary.org/obo/HP_0033335', 'lbl': 'Abnormal preimplantation embryonic development', 'desc': 'label: Abnormal preimplantation embryonic development\ndefinition : An anomaly in the development of the embryo in a stage prior to implantation.\nsynonyms :\n'}


{'id': 'HP_0033336', 'url': 'http://purl.obolibrary.org/obo/HP_0033336', 'lbl': 'Zygotic cleavage failure', 'desc': 'label: Zygotic cleavage failure\ndefinition : Failure of a fertilized oocyte to undergo the first round of cell division.\nsynonyms :Failure of zygotic cell division\n'}


{'id': 'HP_0033337', 'url': 'http://purl.obolibrary.org/obo/HP_0033337', 'lbl': 'Abnormal gametogenesis', 'desc': 'label: Abnormal gametogenesis\ndefinition : An anomaly in the process by a a haploid cell is formed from a diploid cells through meiosis. In males, diploid spermatogonia produce two haploid cells (secondary spermatocytes) in meiosis I and four haploid spermatids in meiosis II. In females, primordial germ cells under meiosis II before birth to form primary oocytes. Once puberty cell begins, these cells form secondary oocytes through meiosis II.\nsynonyms :\n'}


{'id': 'HP_0033338', 'url': 'http://purl.obolibrary.org/obo/HP_0033338', 'lbl': 'Abnormal female meiosis', 'desc': 'label: Abnormal female meiosis\ndefinition : Anomalous oocyte meiosis\nsynonyms :\n'}


{'id': 'HP_0033339', 'url': 'http://purl.obolibrary.org/obo/HP_0033339', 'lbl': 'Increased circulating inosine concentration', 'desc': 'label: Increased circulating inosine concentration\ndefinition : An increased concentration of inosine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033340', 'url': 'http://purl.obolibrary.org/obo/HP_0033340', 'lbl': 'Increased circulating guanosine concentration', 'desc': 'label: Increased circulating guanosine concentration\ndefinition : Increased concentration of guanosine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033341', 'url': 'http://purl.obolibrary.org/obo/HP_0033341', 'lbl': 'Elevated circulating sitosterol concentration', 'desc': 'label: Elevated circulating sitosterol concentration\ndefinition : An increased concentration of beta-sitosterol in the blood circulation.\nsynonyms :Elevated circulating beta-sitosterol concentration\n'}


{'id': 'HP_0033342', 'url': 'http://purl.obolibrary.org/obo/HP_0033342', 'lbl': 'Anti-aquaporin 4 antibody positivity', 'desc': 'label: Anti-aquaporin 4 antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react against aquaporin-4.\nsynonyms :Anti-AQP4 antibody positivity\n'}


{'id': 'HP_0033343', 'url': 'http://purl.obolibrary.org/obo/HP_0033343', 'lbl': 'Mucoid diarrhea', 'desc': 'label: Mucoid diarrhea\ndefinition : Passage of an increased number of stools containing mucus, a thick fluid substance secreted by mucous membranes.\nsynonyms :Mucous diarrhea; Mucous diarrhoea\n'}


{'id': 'HP_0033344', 'url': 'http://purl.obolibrary.org/obo/HP_0033344', 'lbl': 'Pleural cobblestoning', 'desc': 'label: Pleural cobblestoning\ndefinition : A pleural cobblestone appearance characterized by irregular bumps surrounded by depressed lines in open lung biopsy. Caused by underlying scarring causing retraction of the interlobular septa where they insert on the pleura.\nsynonyms :\n'}


{'id': 'HP_0033345', 'url': 'http://purl.obolibrary.org/obo/HP_0033345', 'lbl': 'Neuralgia', 'desc': 'label: Neuralgia\ndefinition : Pain (An unpleasant sensory and emotional experience) along the course of a nerve.\nsynonyms :\n'}


{'id': 'HP_0033346', 'url': 'http://purl.obolibrary.org/obo/HP_0033346', 'lbl': 'Psychic epileptic aura', 'desc': 'label: Psychic epileptic aura\ndefinition : Aura with affective, mnemonic or composite perceptual phenomena including illusory or composite hallucinatory events.\nsynonyms :Psychic aura\n'}


{'id': 'HP_0033347', 'url': 'http://purl.obolibrary.org/obo/HP_0033347', 'lbl': 'Cognitive epileptic aura', 'desc': 'label: Cognitive epileptic aura\ndefinition : A purely subjective manifestation of an epileptic seizure pertaining to altered cognition.\nsynonyms :\n'}


{'id': 'HP_0033348', 'url': 'http://purl.obolibrary.org/obo/HP_0033348', 'lbl': 'Epileptic aura', 'desc': 'label: Epileptic aura\ndefinition : An epileptic aura is a purely subjective clinical manifestation of an epileptic seizure. If an epileptic aura is not followed by loss of awareness or propagation to a bilateral tonic-clonic seizure then it is a type of focal aware non-motor seizure.\nsynonyms :\n'}


{'id': 'HP_0033349', 'url': 'http://purl.obolibrary.org/obo/HP_0033349', 'lbl': 'Seizure cluster', 'desc': 'label: Seizure cluster\ndefinition : A fourfold or greater increase of usual seizure frequency within a 3-day period, where the patient demonstrates full recovery between seizure events within the cluster. The seizure cluster should be recognisable by the primary clinician, carer or patient.\nsynonyms :Acute repetitive seizures; Crescendo seizures; Cyclical seizures; Recurrent seizures; Seizure flurries; Serial seizures\n'}


{'id': 'HP_0033350', 'url': 'http://purl.obolibrary.org/obo/HP_0033350', 'lbl': 'Elevated forced expiratory volume in one second', 'desc': 'label: Elevated forced expiratory volume in one second\ndefinition : An increase in the amount of air a person can forcefully expel in one second, compared to some standard or previous measure of same subject.\nsynonyms :Elevated FEV1\n'}


{'id': 'HP_0033351', 'url': 'http://purl.obolibrary.org/obo/HP_0033351', 'lbl': 'Candida esophagitis', 'desc': 'label: Candida esophagitis\ndefinition : Candida infections of the esophagus are considered opportunistic infections and are seen most commonly in immunosuppressed patients, the most common symptoms being dysphagia, odynophagia, and retrosternal pain.\nsynonyms :Esophageal candidiasis\n'}


{'id': 'HP_0033352', 'url': 'http://purl.obolibrary.org/obo/HP_0033352', 'lbl': 'Pulmonary hypertensive crisis', 'desc': 'label: Pulmonary hypertensive crisis\ndefinition : Pulmonary hypertensive crisis involves sudden and potentially lethal increases in PAP and PVR that cause acute rise in right atrial and right ventricular end-diastolic pressure accompanied by low cardiac output.\nsynonyms :Pulmonary arterial hypertension crisis\n'}


{'id': 'HP_0033353', 'url': 'http://purl.obolibrary.org/obo/HP_0033353', 'lbl': 'Abnormal blood vessel morphology', 'desc': 'label: Abnormal blood vessel morphology\ndefinition : Any structural anomaly of a blood vessel (artery, arteriole, capillary, venule, or vein).\nsynonyms :\n'}


{'id': 'HP_0033354', 'url': 'http://purl.obolibrary.org/obo/HP_0033354', 'lbl': 'Abnormal urine metabolite level', 'desc': 'label: Abnormal urine metabolite level\ndefinition : Any deviation from the normal amount of a metabolite in urine.\nsynonyms :\n'}


{'id': 'HP_0033355', 'url': 'http://purl.obolibrary.org/obo/HP_0033355', 'lbl': 'Increased urine deoxypyridinoline level', 'desc': 'label: Increased urine deoxypyridinoline level\ndefinition : An increased level of deoxypyridinoline in the urine. Deoxypyridinoline is a crosslink product of collagen molecules found in bone and excreted in urine during bone degradation, has been described as a marker of bone turnover.\nsynonyms :Elevated urinary DPD\n'}


{'id': 'HP_0033356', 'url': 'http://purl.obolibrary.org/obo/HP_0033356', 'lbl': 'Elevated circulating o-phosphoserine concentration', 'desc': 'label: Elevated circulating o-phosphoserine concentration\ndefinition : An abnormally increased level of o-phosphoserine in the blood circulation. o-phosphoserine is a derivative of serine.\nsynonyms :\n'}


{'id': 'HP_0033357', 'url': 'http://purl.obolibrary.org/obo/HP_0033357', 'lbl': 'Limited head rotation', 'desc': 'label: Limited head rotation\ndefinition : Reduced range of motion turning the head side to side.\nsynonyms :\n'}


{'id': 'HP_0033358', 'url': 'http://purl.obolibrary.org/obo/HP_0033358', 'lbl': 'Abnormal urine osmolality', 'desc': 'label: Abnormal urine osmolality\ndefinition : A deviation from the normal range of concentration of particles in urine.\nsynonyms :\n'}


{'id': 'HP_0033359', 'url': 'http://purl.obolibrary.org/obo/HP_0033359', 'lbl': 'Hyperosthenuria', 'desc': 'label: Hyperosthenuria\ndefinition : An abnormally high urinary specific gravity, i.e., increased concentration of solutes in the urine.\nsynonyms :\n'}


{'id': 'HP_0033360', 'url': 'http://purl.obolibrary.org/obo/HP_0033360', 'lbl': 'Impaired ability to shift attention', 'desc': 'label: Impaired ability to shift attention\ndefinition : A behavioral abnormality whereby a person is unable to move freely from one situation, activity or aspect of aa problem to another as circumstances demand. Key aspects of shifting include the ability to make transitions, problem solve flexibly, switch or alternate attention, and change focus from one mind-set or topic to another. Mild deficits in the ability to shift compromise the efficiency of problem solving, whereas more severe difficulties are reflected in perseverative behaviors. Sometimes this is described as being rigid or inflexible.\nsynonyms :Impaired task shifting\n'}


{'id': 'HP_0033361', 'url': 'http://purl.obolibrary.org/obo/HP_0033361', 'lbl': 'Nasal ulcer', 'desc': 'label: Nasal ulcer\ndefinition : An open sore of the nasal mucosa.\nsynonyms :\n'}


{'id': 'HP_0033362', 'url': 'http://purl.obolibrary.org/obo/HP_0033362', 'lbl': 'Recurrent coughing spasms', 'desc': 'label: Recurrent coughing spasms\ndefinition : Repeated occurrence of episodes of coughing, with each episode consisting of at least five minutes of continuous coughing.\nsynonyms :\n'}


{'id': 'HP_0033363', 'url': 'http://purl.obolibrary.org/obo/HP_0033363', 'lbl': 'Hyaline membranes', 'desc': 'label: Hyaline membranes\ndefinition : Hyaline membranes are homogeneous eosinophilic material composed of cellular debris, plasma proteins, and surfactant\nplastered against alveolar ducts and alveolar walls. The hyaline membranes are deposited along the walls of the alveoli, where gas exchange typically occurs, thereby making gas exchange difficult.\nsynonyms :\n'}


{'id': 'HP_0033364', 'url': 'http://purl.obolibrary.org/obo/HP_0033364', 'lbl': 'Lipoid pneumonia', 'desc': 'label: Lipoid pneumonia\ndefinition : A specific form of lung inflammation that results from accumulation of lipids in the alveoli. Lipoid pneumonia can be either exogenous or endogenous in cause based on the source of the lipid.\nsynonyms :\n'}


{'id': 'HP_0033365', 'url': 'http://purl.obolibrary.org/obo/HP_0033365', 'lbl': 'Endogenous lipoid pneumonia', 'desc': 'label: Endogenous lipoid pneumonia\ndefinition : A type of lipoid pneumonia in which the source of the lipids is the body itself. When an airway is obstructed, it is often the case that distal to the obstruction, lipid-laden macrophages and giant cells fill the lumen of the disconnected airspace.\nsynonyms :\n'}


{'id': 'HP_0033366', 'url': 'http://purl.obolibrary.org/obo/HP_0033366', 'lbl': 'Exogenous lipoid pneumonia', 'desc': 'label: Exogenous lipoid pneumonia\ndefinition : A type of lipoid pneumonia in which the source of the lipids is external to the body.\nsynonyms :\n'}


{'id': 'HP_0033367', 'url': 'http://purl.obolibrary.org/obo/HP_0033367', 'lbl': 'Orthodeoxia', 'desc': 'label: Orthodeoxia\ndefinition : Low level of blood oxygen induced by changing from a recumbent to an upright position.\nsynonyms :\n'}


{'id': 'HP_0033368', 'url': 'http://purl.obolibrary.org/obo/HP_0033368', 'lbl': 'Platypnea', 'desc': 'label: Platypnea\ndefinition : A type of dyspnea that occurs when the affected person changes from a recumbent to an upright position.\nsynonyms :\n'}


{'id': 'HP_0033369', 'url': 'http://purl.obolibrary.org/obo/HP_0033369', 'lbl': 'Cavitating leukodystrophy', 'desc': 'label: Cavitating leukodystrophy\ndefinition : A type of leukodystrophy characterized by multiple small cavitations typically in the periventricular and deep cerebral white matter. The cavitations are visible as a central cavity with cerebrospinal fluid-like signal intensity.\nsynonyms :\n'}


{'id': 'HP_0033370', 'url': 'http://purl.obolibrary.org/obo/HP_0033370', 'lbl': 'Bronchial telangiectasia', 'desc': 'label: Bronchial telangiectasia\ndefinition : Telangiectasias (small dilated blood vessels located near the surface of the skin or mucous membranes) located in the trachoebronchial system.\nsynonyms :Endobronchial telangiectasia\n'}


{'id': 'HP_0033371', 'url': 'http://purl.obolibrary.org/obo/HP_0033371', 'lbl': 'Bronchocentric granulomatosis', 'desc': 'label: Bronchocentric granulomatosis\ndefinition : Granulomatous inflammation that surrounds the bronchi and bronchioles, replacing bronchial walls and mucosa. In bronchocentric granulomatosis, the lumen of the airway contains necrotic debris, and palisaded histiocytes surround the lumen.\nsynonyms :\n'}


{'id': 'HP_0033372', 'url': 'http://purl.obolibrary.org/obo/HP_0033372', 'lbl': 'Abnormal KCO', 'desc': 'label: Abnormal KCO\ndefinition : Any deviation from the normal range of KCO. The KCO is a measurement of the rate constant for alveolar uptake of CO during breath-holding in the single breath measurement of DLCO at full inflation. The DLCO is derived as the product of the KCO and the single breath alveolar volume (VA) divided by PB-PH2O.\nsynonyms :\n'}


{'id': 'HP_0033373', 'url': 'http://purl.obolibrary.org/obo/HP_0033373', 'lbl': 'Increased KCO', 'desc': 'label: Increased KCO\ndefinition : Increased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index).\nsynonyms :\n'}


{'id': 'HP_0033374', 'url': 'http://purl.obolibrary.org/obo/HP_0033374', 'lbl': 'Decreased KCO', 'desc': 'label: Decreased KCO\ndefinition : Decreased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index).\nsynonyms :\n'}


{'id': 'HP_0033375', 'url': 'http://purl.obolibrary.org/obo/HP_0033375', 'lbl': 'Anthracosis', 'desc': 'label: Anthracosis\ndefinition : Anthracosis is the deposition of black carbon pigment. It is commonly seen in perihilar lymph nodes as well as within lung parenchyma. There can be prominent storiforming (i.e., spiral patterning) of histiocytes, to such an extent as to mimic a neoplastic lesion histologically. Anthracosis is a common finding in smokers and polluted city dwellers.\nsynonyms :\n'}


{'id': 'HP_0033376', 'url': 'http://purl.obolibrary.org/obo/HP_0033376', 'lbl': 'Alveolar septal thickening', 'desc': 'label: Alveolar septal thickening\ndefinition : Increased width of the alveolar septum, which is the structure that separates neighboring alveoli. This finding can be appreciated on histology.\nsynonyms :\n'}


{'id': 'HP_0033377', 'url': 'http://purl.obolibrary.org/obo/HP_0033377', 'lbl': 'Increased airway neuroendocrine cells', 'desc': 'label: Increased airway neuroendocrine cells\ndefinition : Presence of increased numbers of bombesin-immuno-positive neuroendocrine cells (NECs) within distal airways. There are no formal criteria for an increase (which is also dependend on the sensitivity of the staining method), findings of neuroendocrine cells in at least 70% of bronchioles by lung biopsy and at least 10% NECs in an individual airway are consistent with the diagnosis of Neuroendocrine cell hyperplasia of infancy in the appropriate clinical setting. Increases are also seen in other clicnial settings. Neuroendocrine neoplasms of the lung encompass NE tumors (NETs), which split into typical and atypical carcinoids, and NE carcinomas (NECs).\nsynonyms :\n'}


{'id': 'HP_0033378', 'url': 'http://purl.obolibrary.org/obo/HP_0033378', 'lbl': 'Increased airway neuroepithelial bodies', 'desc': 'label: Increased airway neuroepithelial bodies\ndefinition : Presence of increased numbers of bombesin-immuno-positive neuroendocrine cell cluster (neuroepithelial bodies) in the alveolar ducts.\nsynonyms :\n'}


{'id': 'HP_0033379', 'url': 'http://purl.obolibrary.org/obo/HP_0033379', 'lbl': 'Bilateral superior vena cava', 'desc': 'label: Bilateral superior vena cava\ndefinition : The presence of a left and a right superior vena cava.\nsynonyms :Bilateral SVC\n'}


{'id': 'HP_0033380', 'url': 'http://purl.obolibrary.org/obo/HP_0033380', 'lbl': 'Nasal chondritis', 'desc': 'label: Nasal chondritis\ndefinition : Inflammation of the cartilage of the nose.\nsynonyms :Nose chondritis\n'}


{'id': 'HP_0033381', 'url': 'http://purl.obolibrary.org/obo/HP_0033381', 'lbl': 'Elevated circulating stearoylcarnitine concentration', 'desc': 'label: Elevated circulating stearoylcarnitine concentration\ndefinition : Abnormally increased concentration of O-stearoylcarnitine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033382', 'url': 'http://purl.obolibrary.org/obo/HP_0033382', 'lbl': 'Elevated circulating palmitoylcarnitine concentration', 'desc': 'label: Elevated circulating palmitoylcarnitine concentration\ndefinition : Abnormally increased concentration of palmitoylcarnitine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033383', 'url': 'http://purl.obolibrary.org/obo/HP_0033383', 'lbl': 'Decreased compound muscle action potential amplitude', 'desc': 'label: Decreased compound muscle action potential amplitude\ndefinition : Reduced level of the compound muscle action potential (CMAP), which is recorded following electrical stimulation of a nerve from surface electrodes overlying a muscle supplied by that nerve.\nsynonyms :Decreased CMAP amplitude\n'}


{'id': 'HP_0033384', 'url': 'http://purl.obolibrary.org/obo/HP_0033384', 'lbl': 'Elevated urinary collagen degradation products', 'desc': 'label: Elevated urinary collagen degradation products\ndefinition : Increased level in the urine of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease.\nsynonyms :\n'}


{'id': 'HP_0033385', 'url': 'http://purl.obolibrary.org/obo/HP_0033385', 'lbl': 'Elevated urine pyridinoline level', 'desc': 'label: Elevated urine pyridinoline level\ndefinition : An increased amount of pyridinoline in the urine.\nsynonyms :Elevated urine hydroxylysyl-pyridinoline level\n'}


{'id': 'HP_0033386', 'url': 'http://purl.obolibrary.org/obo/HP_0033386', 'lbl': 'Abnormal circulating collagen degradation product concentration', 'desc': 'label: Abnormal circulating collagen degradation product concentration\ndefinition : Abnormal concentration in the blood circulation of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease.\nsynonyms :\n'}


{'id': 'HP_0033387', 'url': 'http://purl.obolibrary.org/obo/HP_0033387', 'lbl': 'Elevated circulating pyridinoline concentration', 'desc': 'label: Elevated circulating pyridinoline concentration\ndefinition : An increased concentration of hydroxylysyl-pyridinoline (pyridinoline) in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033388', 'url': 'http://purl.obolibrary.org/obo/HP_0033388', 'lbl': 'Abnormal bronchial artery morphology', 'desc': 'label: Abnormal bronchial artery morphology\ndefinition : Any structural abnormality of a bronchial artery.\nsynonyms :\n'}


{'id': 'HP_0033389', 'url': 'http://purl.obolibrary.org/obo/HP_0033389', 'lbl': 'Bronchopulmonary anastomosis', 'desc': 'label: Bronchopulmonary anastomosis\ndefinition : Abnormal arterial anastomosis (connection) between bronchial and pulmonary arteries.\nsynonyms :\n'}


{'id': 'HP_0033390', 'url': 'http://purl.obolibrary.org/obo/HP_0033390', 'lbl': 'Bronchial artery dilatation', 'desc': 'label: Bronchial artery dilatation\ndefinition : Increased caliber of a bronchial artery, which can be defined as a bronchial artery diameter that exceeds 2 mm.\nsynonyms :Bronchial artery enlargement; Dilatation of a bronchial artery\n'}


{'id': 'HP_0033391', 'url': 'http://purl.obolibrary.org/obo/HP_0033391', 'lbl': 'Bronchial artery hypertrophy', 'desc': 'label: Bronchial artery hypertrophy\ndefinition : Increase in the volume of bronchial artery wall due to the enlargement of its component cells.\nsynonyms :\n'}


{'id': 'HP_0033392', 'url': 'http://purl.obolibrary.org/obo/HP_0033392', 'lbl': 'Perivascular pre-capillary pulmonary artery inflammation', 'desc': 'label: Perivascular pre-capillary pulmonary artery inflammation\ndefinition : Inflammatory cell infiltration surrounding precapillary pulmonary arteries (arterioles; 20-70 micrometer).\nsynonyms :Perivascular inflammation of arterioles in the pulmonary circulation; Perivascular inflammation of pre-capillary pulmonary arteries\n'}


{'id': 'HP_0033393', 'url': 'http://purl.obolibrary.org/obo/HP_0033393', 'lbl': 'Irregularly shaped sperm tail', 'desc': 'label: Irregularly shaped sperm tail\ndefinition : Irregular or changing caliber (diameter) along the tail of the sperm.\nsynonyms :Sperm flagella with irregular caliber; Sperm flagella with irregular calibre\n'}


{'id': 'HP_0033394', 'url': 'http://purl.obolibrary.org/obo/HP_0033394', 'lbl': 'Anti-carbonic anhydrase II antibody positivity', 'desc': 'label: Anti-carbonic anhydrase II antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase II.\nsynonyms :\n'}


{'id': 'HP_0033395', 'url': 'http://purl.obolibrary.org/obo/HP_0033395', 'lbl': 'Antilactoferrin antibody positivity', 'desc': 'label: Antilactoferrin antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react against lactoferrin.\nsynonyms :\n'}


{'id': 'HP_0033396', 'url': 'http://purl.obolibrary.org/obo/HP_0033396', 'lbl': 'Glomerular extracapillary fibrin', 'desc': 'label: Glomerular extracapillary fibrin\ndefinition : Presence of ropey, eosinophilic material (brght red on Trichrome staining) consistent with extracapillary fibrin outside of capillary lumina.\nsynonyms :\n'}


{'id': 'HP_0033397', 'url': 'http://purl.obolibrary.org/obo/HP_0033397', 'lbl': 'Bowman-space proteinaceous debris', 'desc': "label: Bowman-space proteinaceous debris\ndefinition : The presence of eosinophilic Periodic Acid Schiff (PAS)-positive cell free, protein-derived material occupying Bowman's space.\nsynonyms :\n"}


{'id': 'HP_0033398', 'url': 'http://purl.obolibrary.org/obo/HP_0033398', 'lbl': 'Pleural plaque', 'desc': 'label: Pleural plaque\ndefinition : Deposits of hyalinized collagen fibres in the parietal pleura (preferentially pleura adjacent to ribs, particularly the sixth through ninth ribs).\nsynonyms :\n'}


{'id': 'HP_0033399', 'url': 'http://purl.obolibrary.org/obo/HP_0033399', 'lbl': 'Persistent fever', 'desc': 'label: Persistent fever\ndefinition : Fever that persists longer than expected for an acute infectious disease. No precise threshold exists, and the clinical interpretation of fever is context-dependent, but as a rule of thumb, this term refers to fever that persists longer than 2-3 weeks.\nsynonyms :\n'}


{'id': 'HP_0033400', 'url': 'http://purl.obolibrary.org/obo/HP_0033400', 'lbl': 'Acute abdomen', 'desc': 'label: Acute abdomen\ndefinition : A sudden onset of abdominal pain with associated nausea or vomiting. The acute abdomen may be caused by an infection, inflammation, vascular occlusion, or obstruction.\nsynonyms :Acute abdominal pain\n'}


{'id': 'HP_0033401', 'url': 'http://purl.obolibrary.org/obo/HP_0033401', 'lbl': 'Tissue ischemia', 'desc': 'label: Tissue ischemia\ndefinition : Ischemia is defined as a restriction of arterial blood supply to a tissue associated with insufficient oxygenation to support the metabolis requirements of the tissue. Depending on the involved tissues, clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis. Additional associated manifestations include hemodynamic parameters (reduced blood pressure distal to the site of restricted arterial supply) and angiographic evidence of arterial occclusion.\nsynonyms :\n'}


{'id': 'HP_0033402', 'url': 'http://purl.obolibrary.org/obo/HP_0033402', 'lbl': 'Digital ischemia', 'desc': 'label: Digital ischemia\ndefinition : Restriction of arterial blood supply to a digit (finger or toe) associated with insufficient oxygenation to support the metabolic requirements of the digit. Clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis.\nsynonyms :\n'}


{'id': 'HP_0033403', 'url': 'http://purl.obolibrary.org/obo/HP_0033403', 'lbl': 'Testicular ischemia', 'desc': 'label: Testicular ischemia\ndefinition : Restriction of arterial blood supply to a testis associated with insufficient oxygenation to support the metabolic requirements of the tissue. Clinical manifestations may include pain and swelling of the affected testis.\nsynonyms :\n'}


{'id': 'HP_0033404', 'url': 'http://purl.obolibrary.org/obo/HP_0033404', 'lbl': 'Intestinal ischemia', 'desc': 'label: Intestinal ischemia\ndefinition : Restriction of arterial blood supply to the intestine associated with insufficient oxygenation to support the metabolic requirements of the tissue. Acute intestinal ischemia can involve the small or large intestine, and usually presents with sudden severe non-specific abdominal pain.\nsynonyms :\n'}


{'id': 'HP_0033405', 'url': 'http://purl.obolibrary.org/obo/HP_0033405', 'lbl': 'Abnormal circulating organic amino compound concentration', 'desc': 'label: Abnormal circulating organic amino compound concentration\ndefinition : Any deviation from the normal concentration of an organic amino compound, defined as a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.\nsynonyms :\n'}


{'id': 'HP_0033406', 'url': 'http://purl.obolibrary.org/obo/HP_0033406', 'lbl': 'Elevated circulating o-phosphoethanolamine concentration', 'desc': 'label: Elevated circulating o-phosphoethanolamine concentration\ndefinition : An increased concentration of o-phosphoethanolamine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033407', 'url': 'http://purl.obolibrary.org/obo/HP_0033407', 'lbl': 'Elevated urine acetoacetic acid level', 'desc': 'label: Elevated urine acetoacetic acid level\ndefinition : Elevated amount of acetoacetic acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033408', 'url': 'http://purl.obolibrary.org/obo/HP_0033408', 'lbl': 'Elevated circulating acetoacetic acid concentration', 'desc': 'label: Elevated circulating acetoacetic acid concentration\ndefinition : An increased level of acetoacetic acid in the blood circulation. Acetoacetic acid is one of the predominant ketone bodies.\nsynonyms :\n'}


{'id': 'HP_0033409', 'url': 'http://purl.obolibrary.org/obo/HP_0033409', 'lbl': 'Elevated urinary 2-hydroxybutyric acid', 'desc': 'label: Elevated urinary 2-hydroxybutyric acid\ndefinition : An increased amount of 2-hydroxybutyric acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033410', 'url': 'http://purl.obolibrary.org/obo/HP_0033410', 'lbl': 'Elevated circulating cartilage oligomeric matrix protein concentration', 'desc': 'label: Elevated circulating cartilage oligomeric matrix protein concentration\ndefinition : An increased blood concentration of cartilage oligomeric matrix protein (COMP).\nsynonyms :\n'}


{'id': 'HP_0033411', 'url': 'http://purl.obolibrary.org/obo/HP_0033411', 'lbl': 'Lower extremity akinesia', 'desc': 'label: Lower extremity akinesia\ndefinition : Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the lower extremities.\nsynonyms :\n'}


{'id': 'HP_0033412', 'url': 'http://purl.obolibrary.org/obo/HP_0033412', 'lbl': 'Upper extremity akinesia', 'desc': 'label: Upper extremity akinesia\ndefinition : Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the upper extremities.\nsynonyms :Akinesia of the upper extremities\n'}


{'id': 'HP_0033413', 'url': 'http://purl.obolibrary.org/obo/HP_0033413', 'lbl': 'Upper extremity hypokinesia', 'desc': 'label: Upper extremity hypokinesia\ndefinition : Abnormally diminished movement of the upper extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.\nsynonyms :Hypokinesia of the upper extremities\n'}


{'id': 'HP_0033414', 'url': 'http://purl.obolibrary.org/obo/HP_0033414', 'lbl': 'Lower extremity hypokinesia', 'desc': 'label: Lower extremity hypokinesia\ndefinition : Abnormally diminished movement of the lower extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.\nsynonyms :Hypokinesia of the lower extremities\n'}


{'id': 'HP_0033415', 'url': 'http://purl.obolibrary.org/obo/HP_0033415', 'lbl': 'Cardiac tamponade', 'desc': 'label: Cardiac tamponade\ndefinition : The accumulation of pericardial fluid with subsequent compression of all cardiac chambers which prevents cardiac filling.\nsynonyms :\n'}


{'id': 'HP_0033416', 'url': 'http://purl.obolibrary.org/obo/HP_0033416', 'lbl': 'Hip adductor weakness', 'desc': 'label: Hip adductor weakness\ndefinition : Reduced ability to bring the leg toward the midline of the body.\nsynonyms :\n'}


{'id': 'HP_0033417', 'url': 'http://purl.obolibrary.org/obo/HP_0033417', 'lbl': 'Elevated circulating hydroxybutyric acid concentration', 'desc': 'label: Elevated circulating hydroxybutyric acid concentration\ndefinition : An increased concentration in the blood circulation of a hydroxybutyric acid, that is, of a compound comprising a butyric acid core carrying at least one hydroxy substituent.\nsynonyms :\n'}


{'id': 'HP_0033418', 'url': 'http://purl.obolibrary.org/obo/HP_0033418', 'lbl': 'Elevated circulating 2-hydroxybutyric acid concentration', 'desc': 'label: Elevated circulating 2-hydroxybutyric acid concentration\ndefinition : Elevation of the 2-hydroxybutyric acid concentration in the blood above the normal range.\nsynonyms :\n'}


{'id': 'HP_0033419', 'url': 'http://purl.obolibrary.org/obo/HP_0033419', 'lbl': 'Elevated circulating 3-hydroxybutyric acid concentration', 'desc': 'label: Elevated circulating 3-hydroxybutyric acid concentration\ndefinition : Elevation of the 3-hydroxybutyric acid concentration in the blood above the normal range.\nsynonyms :\n'}


{'id': 'HP_0033420', 'url': 'http://purl.obolibrary.org/obo/HP_0033420', 'lbl': 'Pulmonary arterial plexiform lesion', 'desc': 'label: Pulmonary arterial plexiform lesion\ndefinition : Focal proliferation of pulmonary artery endothelial cells, leading to the formation of complex capillary-like channels.\nsynonyms :\n'}


{'id': 'HP_0033421', 'url': 'http://purl.obolibrary.org/obo/HP_0033421', 'lbl': 'Pulmonary artery intimal thickening', 'desc': 'label: Pulmonary artery intimal thickening\ndefinition : Increased thickness of the intimal layer of the pulmonary artery. Throughout the pulmonary arterial tree, the thin intima consists of a non-fenestrated monolayer of endothelial cells lining the vessel lumen, as well as a sub-endothelial interstitium that extends to the internal elastic lamina. Intimal thickness in human lung ranges from 1-16% of total wall thickness. Pulmonary artery intimal thickening can be defined as a relative intima thickness to the thickness of the vessel wall of over 10%.\nsynonyms :\n'}


{'id': 'HP_0033422', 'url': 'http://purl.obolibrary.org/obo/HP_0033422', 'lbl': 'Pulmonary artery adventitial fibrosis', 'desc': 'label: Pulmonary artery adventitial fibrosis\ndefinition : Increased amount of collagen, proteoglycans, and other extracellular matrix proteins resulting in scarring and thickening in the adventia of the pulmonary arterial tree.\nsynonyms :\n'}


{'id': 'HP_0033423', 'url': 'http://purl.obolibrary.org/obo/HP_0033423', 'lbl': 'Pulmonary arterial hypertension with positive acute response to NO challenge', 'desc': 'label: Pulmonary arterial hypertension with positive acute response to NO challenge\ndefinition : A form of pulmonary arterial hypertension in which there is a reduction of mean pulmonary artery pressure (mPAP) at leasy 10 mmHg to reach an absolute value of mPAP not more than 40 mmHg with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm.\nsynonyms :\n'}


{'id': 'HP_0033424', 'url': 'http://purl.obolibrary.org/obo/HP_0033424', 'lbl': 'Pulmonary arterial hypertension with lack of acute response to NO challenge', 'desc': 'label: Pulmonary arterial hypertension with lack of acute response to NO challenge\ndefinition : A form of pulmonary arterial hypertension with lack of adequate hemodynamic response to NO challenge (adequate response is defined as a reduction of mean pulmonary artery pressure (mPAP) of at least 10 mmHg to reach an absolute value of mPAP 40 mmHg or less with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm).\nsynonyms :\n'}


{'id': 'HP_0033425', 'url': 'http://purl.obolibrary.org/obo/HP_0033425', 'lbl': 'Periungual erythema', 'desc': 'label: Periungual erythema\ndefinition : Erythema (redness of the skin caused by hyperemia in superficial capillaries) in the region surrounding a fingernail or toe nail.\nsynonyms :\n'}


{'id': 'HP_0033426', 'url': 'http://purl.obolibrary.org/obo/HP_0033426', 'lbl': 'Pulmonary air embolism', 'desc': 'label: Pulmonary air embolism\ndefinition : Venous air embolism is a consequence of air being introduced into the venous circulation, and subsequently to the right heart, and pulmonary circulation. When small amounts of air reach pulmonary circulation they can be removed by gas diffusion across the arteriolar wall into the alveoli, amounts of gas exceeding 50 ml can cause pulmonary outflow tract obstruction with or without concomitant arterial embolisation.\nsynonyms :Venous air embolism\n'}


{'id': 'HP_0033427', 'url': 'http://purl.obolibrary.org/obo/HP_0033427', 'lbl': 'Pulmonary capillary angioectasia', 'desc': 'label: Pulmonary capillary angioectasia\ndefinition : Focal accumulation of dilated pulmonary capillaries.\nsynonyms :\n'}


{'id': 'HP_0033428', 'url': 'http://purl.obolibrary.org/obo/HP_0033428', 'lbl': 'Systemic autoinflammation', 'desc': 'label: Systemic autoinflammation\ndefinition : Dysregulation of the innate immune system characterized by systemic pathobiology, i.e., with symptoms that can affect the entire body.\nsynonyms :\n'}


{'id': 'HP_0033429', 'url': 'http://purl.obolibrary.org/obo/HP_0033429', 'lbl': 'Neuroinflammation', 'desc': "label: Neuroinflammation\ndefinition : Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain.\nsynonyms :\n"}


{'id': 'HP_0033430', 'url': 'http://purl.obolibrary.org/obo/HP_0033430', 'lbl': 'Non-infectious meningitis', 'desc': 'label: Non-infectious meningitis\ndefinition : Inflammation of the layers of tissue that cover the brain and spinal cord (meninges) and of the fluid-filled space between the meninges (subarachnoid space) when it is caused by disorders that are not infections or by drugs or vaccines.\nsynonyms :\n'}


{'id': 'HP_0033431', 'url': 'http://purl.obolibrary.org/obo/HP_0033431', 'lbl': 'Cytomegalovirus colitis', 'desc': 'label: Cytomegalovirus colitis\ndefinition : A form of cytomegalovirus infection characterized by infection and inflammation of the colon.\nsynonyms :CMV colitis\n'}


{'id': 'HP_0033432', 'url': 'http://purl.obolibrary.org/obo/HP_0033432', 'lbl': 'Opportunistic viral infection', 'desc': 'label: Opportunistic viral infection\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033433', 'url': 'http://purl.obolibrary.org/obo/HP_0033433', 'lbl': 'Ileocecal ulcer', 'desc': 'label: Ileocecal ulcer\ndefinition : An erosion of the mucous membrane in the region connecting the ileum and cecum.\nsynonyms :Ileo-cecal ulcer\n'}


{'id': 'HP_0033434', 'url': 'http://purl.obolibrary.org/obo/HP_0033434', 'lbl': 'Nasal septum perforation', 'desc': 'label: Nasal septum perforation\ndefinition : A full-thickness defect of the nasal septum.\nsynonyms :Nasal-septum perforation; Perforation of the nasal septum\n'}


{'id': 'HP_0033435', 'url': 'http://purl.obolibrary.org/obo/HP_0033435', 'lbl': 'Abnormal circulating keto acid concentration', 'desc': 'label: Abnormal circulating keto acid concentration\ndefinition : A deviation from the normal concentration of a keto acid in the blood circulation. Keto acids or ketoacids are organic compounds that contain a carboxylic acid group and a ketone group.\nsynonyms :\n'}