{'id': 'HP_0005134', 'url': 'http://purl.obolibrary.org/obo/HP_0005134', 'lbl': 'Absence of the pulmonary valve', 'desc': 'label: Absence of the pulmonary valve\ndefinition : Refers to the specific combination of defects with a severely dysplastic pulmonary valve and massively dilated branch pulmonary arteries.\nsynonyms :Absent pulmonary valve\n'}


{'id': 'HP_0005135', 'url': 'http://purl.obolibrary.org/obo/HP_0005135', 'lbl': 'Abnormal T-wave', 'desc': 'label: Abnormal T-wave\ndefinition : An abnormality of the T wave on the electrocardiogram, which mainly represents the repolarization of the ventricles.\nsynonyms :EKG: T-wave abnormalities; T-wave abnormalities\n'}


{'id': 'HP_0005136', 'url': 'http://purl.obolibrary.org/obo/HP_0005136', 'lbl': 'Mitral annular calcification', 'desc': 'label: Mitral annular calcification\ndefinition : Mitral annular calcification (MAC) results from progressive calcium deposition along and beneath the mitral valve annulus.\nsynonyms :Premature calcification of mitral annulus\n'}


{'id': 'HP_0005141', 'url': 'http://purl.obolibrary.org/obo/HP_0005141', 'lbl': 'obsolete Episodes of ventricular tachycardia', 'desc': 'label: obsolete Episodes of ventricular tachycardia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005143', 'url': 'http://purl.obolibrary.org/obo/HP_0005143', 'lbl': 'Anomalous origin of right pulmonary artery from ascending aorta', 'desc': 'label: Anomalous origin of right pulmonary artery from ascending aorta\ndefinition : The right pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery.\nsynonyms :\n'}


{'id': 'HP_0005144', 'url': 'http://purl.obolibrary.org/obo/HP_0005144', 'lbl': 'Ventricular septal hypertrophy', 'desc': 'label: Ventricular septal hypertrophy\ndefinition : The dividing wall between left and right sides of the heart, thickens and bulges into the left ventricle.\nsynonyms :Thickened interventricular septum\n'}


{'id': 'HP_0005145', 'url': 'http://purl.obolibrary.org/obo/HP_0005145', 'lbl': 'Coronary artery stenosis', 'desc': 'label: Coronary artery stenosis\ndefinition : Abnormal narrowing of the coronary artery.\nsynonyms :Narrowing of coronary artery\n'}


{'id': 'HP_0005146', 'url': 'http://purl.obolibrary.org/obo/HP_0005146', 'lbl': 'Cardiac valve calcification', 'desc': 'label: Cardiac valve calcification\ndefinition : Abnormal calcification of a cardiac valve.\nsynonyms :Calcifications of the cardiac valves\n'}


{'id': 'HP_0005147', 'url': 'http://purl.obolibrary.org/obo/HP_0005147', 'lbl': 'Bidirectional ventricular ectopy', 'desc': 'label: Bidirectional ventricular ectopy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005148', 'url': 'http://purl.obolibrary.org/obo/HP_0005148', 'lbl': 'Pulmonary valve defects', 'desc': 'label: Pulmonary valve defects\ndefinition : Any defect in the valve connecting the heart and the pulmonary artery.\nsynonyms :\n'}


{'id': 'HP_0005150', 'url': 'http://purl.obolibrary.org/obo/HP_0005150', 'lbl': 'Abnormal atrioventricular conduction', 'desc': 'label: Abnormal atrioventricular conduction\ndefinition : An impairment of the electrical continuity between the atria and ventricles.\nsynonyms :\n'}


{'id': 'HP_0005151', 'url': 'http://purl.obolibrary.org/obo/HP_0005151', 'lbl': 'Preductal coarctation of the aorta', 'desc': 'label: Preductal coarctation of the aorta\ndefinition : Narrowing or constriction of the aorta localized proximal to the ductus arteriosus, i.e., to the preductal region of aortic arch.\nsynonyms :Proximal aortic coarctation\n'}


{'id': 'HP_0005152', 'url': 'http://purl.obolibrary.org/obo/HP_0005152', 'lbl': 'Histiocytoid cardiomyopathy', 'desc': 'label: Histiocytoid cardiomyopathy\ndefinition : A type of cardiomyopathy characterized pathologically by hamartomatous lesions of cardiac Purkinje cells.\nsynonyms :Arachnocytosis of the myocardium; Foamy myocardial transformation; Focal lipid cardiomyopathy; Infantile cardiomyopathy with histiocytoid changes; Infantile xanthomatous cardiomyopathy; Isolated cardiac lipidosis; Myocardial or conduction system hamartoma; Oncocytic cardiomyopathy\n'}


{'id': 'HP_0005155', 'url': 'http://purl.obolibrary.org/obo/HP_0005155', 'lbl': 'Ventricular escape rhythm', 'desc': 'label: Ventricular escape rhythm\ndefinition : A ventricular escape rhythm occurs whenever higher-lever pacemakers in AV junction or sinus node fail to control ventricular activation. Escape rate is usually 20-40 bpm, often associated with broad QRS complexes (at least 120 ms).\nsynonyms :Idioventricular escape rhythm\n'}


{'id': 'HP_0005156', 'url': 'http://purl.obolibrary.org/obo/HP_0005156', 'lbl': 'Hypoplastic left atrium', 'desc': 'label: Hypoplastic left atrium\ndefinition : Underdeveloped, small left heart atrium\nsynonyms :Left atrium hypoplasia; Underdeveloped left heart atrium\n'}


{'id': 'HP_0005157', 'url': 'http://purl.obolibrary.org/obo/HP_0005157', 'lbl': 'Concentric hypertrophic cardiomyopathy', 'desc': 'label: Concentric hypertrophic cardiomyopathy\ndefinition : Hypertrophic cardiomyopathy with an symmetrical and concentric pattern of hypertrophy.\nsynonyms :Symmetric, concentric, hypertrophic cardiomyopathy\n'}


{'id': 'HP_0005160', 'url': 'http://purl.obolibrary.org/obo/HP_0005160', 'lbl': 'Total anomalous pulmonary venous return', 'desc': 'label: Total anomalous pulmonary venous return\ndefinition : Total anomalous pulmonary venous return refers to a congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium.\nsynonyms :Total anomalous pulmonary venous connection; Total anomalous pulmonary venous drainage\n'}


{'id': 'HP_0005162', 'url': 'http://purl.obolibrary.org/obo/HP_0005162', 'lbl': 'Abnormal left ventricular function', 'desc': 'label: Abnormal left ventricular function\ndefinition : Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole.\nsynonyms :Impaired left ventricular function; Left ventricular dysfunction; Left ventricular failure; Left ventricular impairment; Left-sided heart failure\n'}


{'id': 'HP_0005164', 'url': 'http://purl.obolibrary.org/obo/HP_0005164', 'lbl': 'Dysplastic pulmonary valve', 'desc': 'label: Dysplastic pulmonary valve\ndefinition : A congenital malformation of the pulmonary valve characterized by leaflet deformation.\nsynonyms :Dysplasia of pulmonary valve; Pulmonary valve dysplasia\n'}


{'id': 'HP_0005165', 'url': 'http://purl.obolibrary.org/obo/HP_0005165', 'lbl': 'Shortened PR interval', 'desc': 'label: Shortened PR interval\ndefinition : Reduced time for the PR interval (beginning of the P wave to the beginning of the QRS complex). In adults, normal values are 120 to 200 ms long.\nsynonyms :Electrocardiographic short PR interval; Short P-R interval; Shortened PR interval on EKG\n'}


{'id': 'HP_0005168', 'url': 'http://purl.obolibrary.org/obo/HP_0005168', 'lbl': 'Elevated right atrial pressure', 'desc': 'label: Elevated right atrial pressure\ndefinition : An abnormal increase in magnitude of the pressure in the right atrium.\nsynonyms :\n'}


{'id': 'HP_0005170', 'url': 'http://purl.obolibrary.org/obo/HP_0005170', 'lbl': 'Complete heart block with broad QRS complexes', 'desc': 'label: Complete heart block with broad QRS complexes\ndefinition : A type of third degree heart block in which the escape rhythm arises at a relatively low part of the conduction system (below the atrioventricular node), which produces a wide QRS complex.\nsynonyms :\n'}


{'id': 'HP_0005172', 'url': 'http://purl.obolibrary.org/obo/HP_0005172', 'lbl': 'Left posterior fascicular block', 'desc': 'label: Left posterior fascicular block\ndefinition : Conduction block in the posterior division of the left bundle branch of the bundle of His.\nsynonyms :Left posterior hemiblock\n'}


{'id': 'HP_0005173', 'url': 'http://purl.obolibrary.org/obo/HP_0005173', 'lbl': 'obsolete Calcific aortic valve stenosis', 'desc': 'label: obsolete Calcific aortic valve stenosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005174', 'url': 'http://purl.obolibrary.org/obo/HP_0005174', 'lbl': 'Membranous subvalvular aortic stenosis', 'desc': 'label: Membranous subvalvular aortic stenosis\ndefinition : Subvalvular stenosis is caused by a diaphragm-like membrane. The stenosis is clinically manifested like any other form of aortic stenosis but is often associated with some aortic insufficiency.\nsynonyms :\n'}


{'id': 'HP_0005176', 'url': 'http://purl.obolibrary.org/obo/HP_0005176', 'lbl': 'Dysplastic aortic valve', 'desc': 'label: Dysplastic aortic valve\ndefinition : A congenital malformation of the aortic valve characterized by leaflet deformation.\nsynonyms :\n'}


{'id': 'HP_0005177', 'url': 'http://purl.obolibrary.org/obo/HP_0005177', 'lbl': 'Premature arteriosclerosis', 'desc': 'label: Premature arteriosclerosis\ndefinition : Arteriosclerosis occurring at an age that is younger than usual.\nsynonyms :Premature hardening of arteries\n'}


{'id': 'HP_0005178', 'url': 'http://purl.obolibrary.org/obo/HP_0005178', 'lbl': 'Complete heart block with narrow QRS complexes', 'desc': 'label: Complete heart block with narrow QRS complexes\ndefinition : A type of third degree heart block in which the escape rhythm arises at the atrioventricular node, which produces a narrow QRS complex.\nsynonyms :\n'}


{'id': 'HP_0005180', 'url': 'http://purl.obolibrary.org/obo/HP_0005180', 'lbl': 'Tricuspid regurgitation', 'desc': 'label: Tricuspid regurgitation\ndefinition : Failure of the tricuspid valve to close sufficiently upon contraction of the right ventricle, causing blood to regurgitate (flow backward) into the right atrium.\nsynonyms :Tricuspid insufficiency; Tricuspid valve regurgitation\n'}


{'id': 'HP_0005181', 'url': 'http://purl.obolibrary.org/obo/HP_0005181', 'lbl': 'Premature coronary artery atherosclerosis', 'desc': 'label: Premature coronary artery atherosclerosis\ndefinition : Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries before age of 45.\nsynonyms :Premature coronary artery disease\n'}


{'id': 'HP_0005182', 'url': 'http://purl.obolibrary.org/obo/HP_0005182', 'lbl': 'Bicuspid pulmonary valve', 'desc': 'label: Bicuspid pulmonary valve\ndefinition : The presence of a bicuspid pulmonary valve.\nsynonyms :\n'}


{'id': 'HP_0005183', 'url': 'http://purl.obolibrary.org/obo/HP_0005183', 'lbl': 'Pericardial lymphangiectasia', 'desc': 'label: Pericardial lymphangiectasia\ndefinition : An abnormal dilatation of lymph vessels in the pericardium.\nsynonyms :\n'}


{'id': 'HP_0005184', 'url': 'http://purl.obolibrary.org/obo/HP_0005184', 'lbl': 'Prolonged QTc interval', 'desc': "label: Prolonged QTc interval\ndefinition : A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.\nsynonyms :\n"}


{'id': 'HP_0005185', 'url': 'http://purl.obolibrary.org/obo/HP_0005185', 'lbl': 'Global systolic dysfunction', 'desc': 'label: Global systolic dysfunction\ndefinition : A reduced ejection fraction and an enlarged left ventricle chamber, the latter by an increased resistance to filling with increased filling pressures. Systolic dysfunction is clinically associated with left ventricular failure in the presence of marked cardiomegaly.\nsynonyms :\n'}


{'id': 'HP_0005186', 'url': 'http://purl.obolibrary.org/obo/HP_0005186', 'lbl': 'Synovial hypertrophy', 'desc': 'label: Synovial hypertrophy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005187', 'url': 'http://purl.obolibrary.org/obo/HP_0005187', 'lbl': 'Progressive joint destruction', 'desc': 'label: Progressive joint destruction\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005190', 'url': 'http://purl.obolibrary.org/obo/HP_0005190', 'lbl': 'Proximal finger joint hyperextensibility', 'desc': 'label: Proximal finger joint hyperextensibility\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005191', 'url': 'http://purl.obolibrary.org/obo/HP_0005191', 'lbl': 'Congenital knee dislocation', 'desc': 'label: Congenital knee dislocation\ndefinition : \nsynonyms :Dislocated knee since birth\n'}


{'id': 'HP_0005193', 'url': 'http://purl.obolibrary.org/obo/HP_0005193', 'lbl': 'Restricted large joint movement', 'desc': 'label: Restricted large joint movement\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005194', 'url': 'http://purl.obolibrary.org/obo/HP_0005194', 'lbl': 'Flattened metatarsal heads', 'desc': 'label: Flattened metatarsal heads\ndefinition : Abnormally flat shape of the heads of the metatarsal bones.\nsynonyms :Flattened head of long bone of foot\n'}


{'id': 'HP_0005195', 'url': 'http://purl.obolibrary.org/obo/HP_0005195', 'lbl': 'Polyarticular arthropathy', 'desc': 'label: Polyarticular arthropathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005197', 'url': 'http://purl.obolibrary.org/obo/HP_0005197', 'lbl': 'Generalized morning stiffness', 'desc': 'label: Generalized morning stiffness\ndefinition : A sensation of stiffness in the joints that occurs following waking up in the morning.\nsynonyms :Generalised morning stiffness\n'}


{'id': 'HP_0005198', 'url': 'http://purl.obolibrary.org/obo/HP_0005198', 'lbl': 'Stiff interphalangeal joints', 'desc': 'label: Stiff interphalangeal joints\ndefinition : Interphalangeal joint stiffness is a perceived sensation of tightness in the interphalangeal joints when attempting to move them after a period of inactivity.\nsynonyms :Stiff hinge joints\n'}


{'id': 'HP_0005199', 'url': 'http://purl.obolibrary.org/obo/HP_0005199', 'lbl': 'Aplasia of the abdominal wall musculature', 'desc': 'label: Aplasia of the abdominal wall musculature\ndefinition : Absence of the abdominal musculature.\nsynonyms :Absent abdominal musculature\n'}


{'id': 'HP_0005200', 'url': 'http://purl.obolibrary.org/obo/HP_0005200', 'lbl': 'Retroperitoneal fibrosis', 'desc': 'label: Retroperitoneal fibrosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005201', 'url': 'http://purl.obolibrary.org/obo/HP_0005201', 'lbl': 'Anomalous splenoportal venous system', 'desc': 'label: Anomalous splenoportal venous system\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005202', 'url': 'http://purl.obolibrary.org/obo/HP_0005202', 'lbl': 'Helicobacter pylori infection', 'desc': 'label: Helicobacter pylori infection\ndefinition : A recurrent infection of the GI tract with helicobacter pylori, a gram-negative, microaerophilic bacterium usually found in the stomach.\nsynonyms :\n'}


{'id': 'HP_0005203', 'url': 'http://purl.obolibrary.org/obo/HP_0005203', 'lbl': 'Spontaneous esophageal perforation', 'desc': 'label: Spontaneous esophageal perforation\ndefinition : The occurrence of the full-thickness tear (perforation) of the wall of the esophagus.\nsynonyms :Spontaneous esophageal rupture; Boerhaave syndrome\n'}


{'id': 'HP_0005206', 'url': 'http://purl.obolibrary.org/obo/HP_0005206', 'lbl': 'Pancreatic pseudocyst', 'desc': 'label: Pancreatic pseudocyst\ndefinition : Cyst-like space not lined by epithelium and contained within the pancreas. Pancreatic pseudocysts are often associated with pancreatitis.\nsynonyms :\n'}


{'id': 'HP_0005207', 'url': 'http://purl.obolibrary.org/obo/HP_0005207', 'lbl': 'Gastric hypertrophy', 'desc': 'label: Gastric hypertrophy\ndefinition : Hypertrophy of the stomach.\nsynonyms :Increased stomach size\n'}


{'id': 'HP_0005208', 'url': 'http://purl.obolibrary.org/obo/HP_0005208', 'lbl': 'Secretory diarrhea', 'desc': 'label: Secretory diarrhea\ndefinition : Watery voluminous diarrhea resulting from an imbalance between ion and water secretion and absorption.\nsynonyms :Secretory diarrhoea\n'}


{'id': 'HP_0005209', 'url': 'http://purl.obolibrary.org/obo/HP_0005209', 'lbl': 'Intrahepatic bile duct cysts', 'desc': 'label: Intrahepatic bile duct cysts\ndefinition : The presence of cyst of the intrahepatic bile duct.\nsynonyms :\n'}


{'id': 'HP_0005210', 'url': 'http://purl.obolibrary.org/obo/HP_0005210', 'lbl': 'Hypoplastic colon', 'desc': 'label: Hypoplastic colon\ndefinition : Underdevelopment of the colon.\nsynonyms :Hypoplasia of the colon; Underdeveloped colon\n'}


{'id': 'HP_0005211', 'url': 'http://purl.obolibrary.org/obo/HP_0005211', 'lbl': 'Midgut malrotation', 'desc': 'label: Midgut malrotation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005212', 'url': 'http://purl.obolibrary.org/obo/HP_0005212', 'lbl': 'Anal mucosal leukoplakia', 'desc': "label: Anal mucosal leukoplakia\ndefinition : Leukoplakia is a precancerous dermatosis of mucous membranes analogous Leukoplakia is basically a chronic inflammatory hypertrophy in which anaplasia and malignant dyskeratosis may develop and subsequently advance to an invasive squamous cell cancer. The clinical diagnosis of primary anal leukoplakia is indicated by single or multiple slightly raised,irregular, marginated, grayish-white keratinized' patches in the anal canal. Tissue biopsy is necessary for confirmation.\nsynonyms :\n"}


{'id': 'HP_0005213', 'url': 'http://purl.obolibrary.org/obo/HP_0005213', 'lbl': 'Pancreatic calcification', 'desc': 'label: Pancreatic calcification\ndefinition : The presence of abnormal calcium deposition lesions in the pancreas.\nsynonyms :Pancreatic calcifications\n'}


{'id': 'HP_0005214', 'url': 'http://purl.obolibrary.org/obo/HP_0005214', 'lbl': 'Intestinal obstruction', 'desc': 'label: Intestinal obstruction\ndefinition : Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal.\nsynonyms :Bowel obstruction; Intestinal blockage; Intestinal obstruction\n'}


{'id': 'HP_0005215', 'url': 'http://purl.obolibrary.org/obo/HP_0005215', 'lbl': 'Frequent Giardia lamblia infestation', 'desc': 'label: Frequent Giardia lamblia infestation\ndefinition : Increased susceptibility to Giardia lamblia infection of the intestine, as manifested by a medical history of multiple episodes of Giardia lamblia intestinal infection.\nsynonyms :\n'}


{'id': 'HP_0005216', 'url': 'http://purl.obolibrary.org/obo/HP_0005216', 'lbl': 'Impaired mastication', 'desc': 'label: Impaired mastication\ndefinition : An abnormal reduction in the ability to masticate (chew), i.e., in the ability to crush and ground food in preparation for swallowing.\nsynonyms :Chewing difficulties; Chewing difficulty; Difficulty chewing\n'}


{'id': 'HP_0005217', 'url': 'http://purl.obolibrary.org/obo/HP_0005217', 'lbl': 'Duplication of internal organs', 'desc': 'label: Duplication of internal organs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005218', 'url': 'http://purl.obolibrary.org/obo/HP_0005218', 'lbl': 'Anoperineal fistula', 'desc': 'label: Anoperineal fistula\ndefinition : The presence of a fistula (abnormal tunnel) between the anal canal and the perineum.\nsynonyms :Perianal fistula\n'}


{'id': 'HP_0005219', 'url': 'http://purl.obolibrary.org/obo/HP_0005219', 'lbl': 'Absence of intrinsic factor', 'desc': 'label: Absence of intrinsic factor\ndefinition : Absence of gastric intrinsic factor, which is normally produced by the parietal cells of the stomach, and is required for the absorption of vitamin B12.\nsynonyms :Intrinsic factor absent from gastric juice\n'}


{'id': 'HP_0005220', 'url': 'http://purl.obolibrary.org/obo/HP_0005220', 'lbl': 'Multiple intestinal neurofibromatosis', 'desc': 'label: Multiple intestinal neurofibromatosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005222', 'url': 'http://purl.obolibrary.org/obo/HP_0005222', 'lbl': 'Bowel diverticulosis', 'desc': 'label: Bowel diverticulosis\ndefinition : The presence of multiple diverticula of the intestine.\nsynonyms :Bowel diverticula\n'}


{'id': 'HP_0005223', 'url': 'http://purl.obolibrary.org/obo/HP_0005223', 'lbl': 'Duplicated colon', 'desc': 'label: Duplicated colon\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005224', 'url': 'http://purl.obolibrary.org/obo/HP_0005224', 'lbl': 'Rectal abscess', 'desc': 'label: Rectal abscess\ndefinition : A collection of pus in the area of the rectum.\nsynonyms :Perirectal abscess\n'}


{'id': 'HP_0005225', 'url': 'http://purl.obolibrary.org/obo/HP_0005225', 'lbl': 'Intestinal edema', 'desc': 'label: Intestinal edema\ndefinition : Accumulation of cell free, noninflammatony fluid within the wall of the intestinal tract producing uniform thickening of the mucosal folds.\nsynonyms :Intestinal oedema\n'}


{'id': 'HP_0005227', 'url': 'http://purl.obolibrary.org/obo/HP_0005227', 'lbl': 'Adenomatous colonic polyposis', 'desc': 'label: Adenomatous colonic polyposis\ndefinition : Presence of multiple adenomatous polyps in the colon.\nsynonyms :Multiple adenomatous colon polyps; Multiple colonic adenomatous polyps\n'}


{'id': 'HP_0005229', 'url': 'http://purl.obolibrary.org/obo/HP_0005229', 'lbl': 'Jejunoileal ulceration', 'desc': 'label: Jejunoileal ulceration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005230', 'url': 'http://purl.obolibrary.org/obo/HP_0005230', 'lbl': 'Biliary tract obstruction', 'desc': 'label: Biliary tract obstruction\ndefinition : Obstruction affecting the biliary tree.\nsynonyms :\n'}


{'id': 'HP_0005231', 'url': 'http://purl.obolibrary.org/obo/HP_0005231', 'lbl': 'Chronic gastritis', 'desc': 'label: Chronic gastritis\ndefinition : A chronic form of gastritis.\nsynonyms :\n'}


{'id': 'HP_0005232', 'url': 'http://purl.obolibrary.org/obo/HP_0005232', 'lbl': 'Pancreatic dysplasia', 'desc': 'label: Pancreatic dysplasia\ndefinition : The presence of developmental dysplasia of the pancreas.\nsynonyms :\n'}


{'id': 'HP_0005233', 'url': 'http://purl.obolibrary.org/obo/HP_0005233', 'lbl': 'Hypoplasia of the gallbladder', 'desc': 'label: Hypoplasia of the gallbladder\ndefinition : The presence of a hypoplastic gallbladder.\nsynonyms :Hypoplastic gallbladder\n'}


{'id': 'HP_0005234', 'url': 'http://purl.obolibrary.org/obo/HP_0005234', 'lbl': 'Neonatal intestinal obstruction', 'desc': 'label: Neonatal intestinal obstruction\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005235', 'url': 'http://purl.obolibrary.org/obo/HP_0005235', 'lbl': 'Jejunal atresia', 'desc': 'label: Jejunal atresia\ndefinition : A developmental defect resulting in abnormal closure, or atresia of the tubular structure of the jejunum.\nsynonyms :\n'}


{'id': 'HP_0005236', 'url': 'http://purl.obolibrary.org/obo/HP_0005236', 'lbl': 'Chronic calcifying pancreatitis', 'desc': 'label: Chronic calcifying pancreatitis\ndefinition : A form of chronic pancreatitis that is characterized by calcification.\nsynonyms :\n'}


{'id': 'HP_0005237', 'url': 'http://purl.obolibrary.org/obo/HP_0005237', 'lbl': 'Degenerative liver disease', 'desc': 'label: Degenerative liver disease\ndefinition : The presence of degenerative changes of the liver.\nsynonyms :\n'}


{'id': 'HP_0005238', 'url': 'http://purl.obolibrary.org/obo/HP_0005238', 'lbl': 'Discrete intestinal polyps', 'desc': 'label: Discrete intestinal polyps\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005240', 'url': 'http://purl.obolibrary.org/obo/HP_0005240', 'lbl': 'Esophageal obstruction', 'desc': 'label: Esophageal obstruction\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005241', 'url': 'http://purl.obolibrary.org/obo/HP_0005241', 'lbl': 'Total intestinal aganglionosis', 'desc': 'label: Total intestinal aganglionosis\ndefinition : A congenital defect characterized by the lack of ganglion cells in the entire intestine, i.e., the aganglionic segment comprises the entire large and small bowel.\nsynonyms :\n'}


{'id': 'HP_0005242', 'url': 'http://purl.obolibrary.org/obo/HP_0005242', 'lbl': 'Extrahepatic biliary duct atresia', 'desc': 'label: Extrahepatic biliary duct atresia\ndefinition : Atresia in the extrahepatic bile duct.\nsynonyms :Biliary atresia, extrahepatic\n'}


{'id': 'HP_0005243', 'url': 'http://purl.obolibrary.org/obo/HP_0005243', 'lbl': 'Partial abdominal muscle agenesis', 'desc': 'label: Partial abdominal muscle agenesis\ndefinition : Failure to form of portions of the abdominal musculature.\nsynonyms :\n'}


{'id': 'HP_0005244', 'url': 'http://purl.obolibrary.org/obo/HP_0005244', 'lbl': 'Gastrointestinal infarctions', 'desc': 'label: Gastrointestinal infarctions\ndefinition : \nsynonyms :Death of digestive organ tissue due to poor blood supply; GI infarctions\n'}


{'id': 'HP_0005245', 'url': 'http://purl.obolibrary.org/obo/HP_0005245', 'lbl': 'Intestinal hypoplasia', 'desc': 'label: Intestinal hypoplasia\ndefinition : Developmental hypoplasia of the intestine.\nsynonyms :Hypoplastic intestines; Underdeveloped instestine\n'}


{'id': 'HP_0005246', 'url': 'http://purl.obolibrary.org/obo/HP_0005246', 'lbl': 'Giant hypertrophic gastritis', 'desc': 'label: Giant hypertrophic gastritis\ndefinition : A type of gastritis characterized by excessive proliferation of the gastric mucosa and diffuse thickening of the gastric mucosal folds.\nsynonyms :Menetrier disease\n'}


{'id': 'HP_0005247', 'url': 'http://purl.obolibrary.org/obo/HP_0005247', 'lbl': 'Hypoplasia of the abdominal wall musculature', 'desc': 'label: Hypoplasia of the abdominal wall musculature\ndefinition : Underdevelopment of the abdominal musculature.\nsynonyms :Abdominal muscular hypoplasia\n'}


{'id': 'HP_0005248', 'url': 'http://purl.obolibrary.org/obo/HP_0005248', 'lbl': 'Intrahepatic biliary atresia', 'desc': 'label: Intrahepatic biliary atresia\ndefinition : Atresia in the intrahepatic bile duct.\nsynonyms :Bile duct paucity; Intrahepatic atresia of biliary duct\n'}


{'id': 'HP_0005249', 'url': 'http://purl.obolibrary.org/obo/HP_0005249', 'lbl': 'Functional intestinal obstruction', 'desc': 'label: Functional intestinal obstruction\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005250', 'url': 'http://purl.obolibrary.org/obo/HP_0005250', 'lbl': 'High intestinal obstruction', 'desc': 'label: High intestinal obstruction\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005253', 'url': 'http://purl.obolibrary.org/obo/HP_0005253', 'lbl': 'Increased anterioposterior diameter of thorax', 'desc': 'label: Increased anterioposterior diameter of thorax\ndefinition : \nsynonyms :Increased anterioposterior diameter of chest\n'}


{'id': 'HP_0005254', 'url': 'http://purl.obolibrary.org/obo/HP_0005254', 'lbl': 'Unilateral chest hypoplasia', 'desc': 'label: Unilateral chest hypoplasia\ndefinition : \nsynonyms :Small chest on one side; Underdeveloped chest on one side\n'}


{'id': 'HP_0005255', 'url': 'http://purl.obolibrary.org/obo/HP_0005255', 'lbl': 'Absence of pectoralis minor muscle', 'desc': 'label: Absence of pectoralis minor muscle\ndefinition : Aplasia (congenital absence) of the pectoralis minor.\nsynonyms :Pectoralis minor aplasia\n'}


{'id': 'HP_0005256', 'url': 'http://purl.obolibrary.org/obo/HP_0005256', 'lbl': 'Unilateral absence of pectoralis major muscle', 'desc': 'label: Unilateral absence of pectoralis major muscle\ndefinition : Aplasia (congenital absence) of the pectoralis minor on only one side of the chest.\nsynonyms :Unilateral aplasia of pectoralis major muscle\n'}


{'id': 'HP_0005257', 'url': 'http://purl.obolibrary.org/obo/HP_0005257', 'lbl': 'Thoracic hypoplasia', 'desc': 'label: Thoracic hypoplasia\ndefinition : \nsynonyms :Small chest; Small thorax\n'}


{'id': 'HP_0005258', 'url': 'http://purl.obolibrary.org/obo/HP_0005258', 'lbl': 'Pectoral muscle hypoplasia/aplasia', 'desc': 'label: Pectoral muscle hypoplasia/aplasia\ndefinition : \nsynonyms :Small/absent pec muscle; Underdeveloped/absent pec muscle\n'}


{'id': 'HP_0005259', 'url': 'http://purl.obolibrary.org/obo/HP_0005259', 'lbl': 'Abnormal facility in opposing the shoulders', 'desc': 'label: Abnormal facility in opposing the shoulders\ndefinition : Increased range of shoulder movement related to aplasia or hypoplasia of the clavicles that results in the ability to approximate the shoulders in front of the chest.\nsynonyms :\n'}


{'id': 'HP_0005261', 'url': 'http://purl.obolibrary.org/obo/HP_0005261', 'lbl': 'Joint hemorrhage', 'desc': 'label: Joint hemorrhage\ndefinition : Hemorrhage occurring within a joint.\nsynonyms :Bleeding within a joint; Hemarthroses; Hemarthrosis; Joint haemorrhage; Spontaneous joint haemorrhage; Spontaneous joint hemorrhage\n'}


{'id': 'HP_0005262', 'url': 'http://purl.obolibrary.org/obo/HP_0005262', 'lbl': 'Abnormality of the synovia', 'desc': 'label: Abnormality of the synovia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005263', 'url': 'http://purl.obolibrary.org/obo/HP_0005263', 'lbl': 'Gastritis', 'desc': 'label: Gastritis\ndefinition : The presence of inflammation of the gastric mucous membrane.\nsynonyms :Stomach inflammation\n'}


{'id': 'HP_0005264', 'url': 'http://purl.obolibrary.org/obo/HP_0005264', 'lbl': 'Abnormality of the gallbladder', 'desc': 'label: Abnormality of the gallbladder\ndefinition : An abnormality of the gallbladder.\nsynonyms :Abnormality of the gallbladder; Anomaly of the gallbladder\n'}


{'id': 'HP_0005265', 'url': 'http://purl.obolibrary.org/obo/HP_0005265', 'lbl': 'Abnormal jejunum morphology', 'desc': 'label: Abnormal jejunum morphology\ndefinition : An abnormality of the jejunum, i.e., of the middle section of the small intestine.\nsynonyms :Abnormality of the jejunum\n'}


{'id': 'HP_0005266', 'url': 'http://purl.obolibrary.org/obo/HP_0005266', 'lbl': 'Intestinal polyp', 'desc': 'label: Intestinal polyp\ndefinition : A discrete abnormal tissue mass that protrudes into the lumen of the intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base.\nsynonyms :Intestinal polyps\n'}


{'id': 'HP_0005267', 'url': 'http://purl.obolibrary.org/obo/HP_0005267', 'lbl': 'Premature delivery because of cervical insufficiency or membrane fragility', 'desc': 'label: Premature delivery because of cervical insufficiency or membrane fragility\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005268', 'url': 'http://purl.obolibrary.org/obo/HP_0005268', 'lbl': 'Miscarriage', 'desc': 'label: Miscarriage\ndefinition : A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 22th week of pregnancy.\nsynonyms :Early fetal demise; Spontaneous abortion\n'}


{'id': 'HP_0005272', 'url': 'http://purl.obolibrary.org/obo/HP_0005272', 'lbl': 'Prominent nasolabial fold', 'desc': 'label: Prominent nasolabial fold\ndefinition : Exaggerated bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion, or commissure).\nsynonyms :Deep laugh lines; Deep nasolabial crease; Deep nasolabial fold; Deep nasolabial groove; Deep smile lines; Nasolabial crease, prominent; Prominent laugh lines; Prominent nasolabial groove; Prominent smile lines\n'}


{'id': 'HP_0005273', 'url': 'http://purl.obolibrary.org/obo/HP_0005273', 'lbl': 'Absent nasal septal cartilage', 'desc': 'label: Absent nasal septal cartilage\ndefinition : Lack of the cartilage of the nasal septum.\nsynonyms :Absent nasal septal cartilage; Absent nasal septum; Ageneis of nasal septal cartilage; Failure of development of nasal septal cartilage\n'}


{'id': 'HP_0005274', 'url': 'http://purl.obolibrary.org/obo/HP_0005274', 'lbl': 'Prominent nasal tip', 'desc': 'label: Prominent nasal tip\ndefinition : \nsynonyms :Large nasal tip; Large tip of nose; Prominent nasal tip; Prominent tip of nose; Pronounced nasal tip; Pronounced tip of nose; Bulbous tip of nose; Hyperplasia of nasal tip; Hyperplasia of tip of nose; Hypertrophy of nasal tip; Hypertrophy of tip of nose\n'}


{'id': 'HP_0005275', 'url': 'http://purl.obolibrary.org/obo/HP_0005275', 'lbl': 'Cartilaginous ossification of nose', 'desc': 'label: Cartilaginous ossification of nose\ndefinition : \nsynonyms :Cartilaginous nasal ossification\n'}


{'id': 'HP_0005278', 'url': 'http://purl.obolibrary.org/obo/HP_0005278', 'lbl': 'Hypoplastic nasal tip', 'desc': 'label: Hypoplastic nasal tip\ndefinition : \nsynonyms :Decreased size of nasal tip; Decreased size of tip of nose; Hypoplasia of tip of nose; Small nasal tip; Small tip of nose; Underdevelopment of nasal tip; Underdevelopment of tip of nose; Aplasia of nasal tip; Deficient nasal tip; Hypotrophic nasal tip; Hypotrophic tip of nose\n'}


{'id': 'HP_0005280', 'url': 'http://purl.obolibrary.org/obo/HP_0005280', 'lbl': 'Depressed nasal bridge', 'desc': 'label: Depressed nasal bridge\ndefinition : Posterior positioning of the nasal root in relation to the overall facial profile for age.\nsynonyms :Depressed bridge of nose; Depressed nasal bridge; Depressed nasal root; Flat bridge of nose; Flat nasal bridge; Flat nasal root; Flat, nasal bridge; Flattened nasal bridge; Low nasal bridge; Low nasal root; Retruded bridge of nose; Retruded nasal bridge; Concave bridge of nose; Concave nasal bridge; Depressed nasal root/bridge\n'}


{'id': 'HP_0005281', 'url': 'http://purl.obolibrary.org/obo/HP_0005281', 'lbl': 'Hypoplastic nasal bridge', 'desc': 'label: Hypoplastic nasal bridge\ndefinition : \nsynonyms :Decreased size of bridge of nose; Decreased size of nasal bridge; Hypoplastic bridge of nose; Small bridge of nose; Small nasal bridge; Hypotrophic bridge of nose; Hypotrophic nasal bridge\n'}


{'id': 'HP_0005285', 'url': 'http://purl.obolibrary.org/obo/HP_0005285', 'lbl': 'Absent nasal bridge', 'desc': 'label: Absent nasal bridge\ndefinition : \nsynonyms :Absent bridge of nose; Absent nasal bridge; Agenesis of bridge of nose; Agenesis of nasal bridge; Missing bridge of nose; Missing nasal bridge\n'}


{'id': 'HP_0005288', 'url': 'http://purl.obolibrary.org/obo/HP_0005288', 'lbl': 'Abnormal nostril morphology', 'desc': 'label: Abnormal nostril morphology\ndefinition : Abnormality of the nostril.\nsynonyms :Abnormal naris morphology; Abnormality of the nares; Abnormality of the nostrils; Anomaly of the nares; Deformity of the nares; Deformity of the nostrils; Malformation of the nares; Malformation of the nostrils\n'}


{'id': 'HP_0005289', 'url': 'http://purl.obolibrary.org/obo/HP_0005289', 'lbl': 'Abnormality of the nasolabial region', 'desc': 'label: Abnormality of the nasolabial region\ndefinition : \nsynonyms :Anomaly of the nasolabial region; Deformity of the nasolabial region; Malformation of the nasolabial region\n'}


{'id': 'HP_0005290', 'url': 'http://purl.obolibrary.org/obo/HP_0005290', 'lbl': 'Internal carotid artery hypoplasia', 'desc': 'label: Internal carotid artery hypoplasia\ndefinition : \nsynonyms :Decreased size of internal carotid artery; Small internal carotid artery; Aplasia of internal carotid artery; Deficiency of internal carotid artery; Hypotrophic internal carotid artery\n'}


{'id': 'HP_0005291', 'url': 'http://purl.obolibrary.org/obo/HP_0005291', 'lbl': 'Inflammatory arteriopathy', 'desc': 'label: Inflammatory arteriopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005292', 'url': 'http://purl.obolibrary.org/obo/HP_0005292', 'lbl': 'Intimal thickening in the coronary arteries', 'desc': 'label: Intimal thickening in the coronary arteries\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005293', 'url': 'http://purl.obolibrary.org/obo/HP_0005293', 'lbl': 'Venous insufficiency', 'desc': 'label: Venous insufficiency\ndefinition : \nsynonyms :Poorly functioning veins\n'}


{'id': 'HP_0005294', 'url': 'http://purl.obolibrary.org/obo/HP_0005294', 'lbl': 'Arterial dissection', 'desc': 'label: Arterial dissection\ndefinition : A separation (dissection) of the layers of an artery.\nsynonyms :\n'}


{'id': 'HP_0005295', 'url': 'http://purl.obolibrary.org/obo/HP_0005295', 'lbl': 'Pseudocoarctation of the aorta', 'desc': 'label: Pseudocoarctation of the aorta\ndefinition : Pseudocoarctation is a congenital anomaly of kinking, or buckling, of the aorta without a pressure gradient across the lesion. It is characterized by elongation and kinking of the aorta at the level of the ligamentum arteriosum.\nsynonyms :\n'}


{'id': 'HP_0005296', 'url': 'http://purl.obolibrary.org/obo/HP_0005296', 'lbl': 'obsolete Occlusive vascular disease', 'desc': 'label: obsolete Occlusive vascular disease\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005297', 'url': 'http://purl.obolibrary.org/obo/HP_0005297', 'lbl': 'Premature occlusive vascular stenosis', 'desc': 'label: Premature occlusive vascular stenosis\ndefinition : Peripheral arterial stenosis with onset before the age of 50 years.\nsynonyms :\n'}


{'id': 'HP_0005298', 'url': 'http://purl.obolibrary.org/obo/HP_0005298', 'lbl': 'obsolete Atrioventricular canal defect with right ventricle aorta and pulmonary atresia', 'desc': 'label: obsolete Atrioventricular canal defect with right ventricle aorta and pulmonary atresia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005299', 'url': 'http://purl.obolibrary.org/obo/HP_0005299', 'lbl': 'obsolete Premature peripheral vascular disease', 'desc': 'label: obsolete Premature peripheral vascular disease\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005300', 'url': 'http://purl.obolibrary.org/obo/HP_0005300', 'lbl': 'Nodular inflammatory vasculitis', 'desc': 'label: Nodular inflammatory vasculitis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005301', 'url': 'http://purl.obolibrary.org/obo/HP_0005301', 'lbl': 'Persistent left superior vena cava', 'desc': 'label: Persistent left superior vena cava\ndefinition : A rare congenital vascular anomaly that results when the left superior cardinal vein caudal to the innominate vein fails to regress.\nsynonyms :PLSVC\n'}


{'id': 'HP_0005302', 'url': 'http://purl.obolibrary.org/obo/HP_0005302', 'lbl': 'Carotid artery tortuosity', 'desc': 'label: Carotid artery tortuosity\ndefinition : Abnormal tortuous (i.e., twisted) form of the carotid arteries.\nsynonyms :Tortuous carotid arteries\n'}


{'id': 'HP_0005303', 'url': 'http://purl.obolibrary.org/obo/HP_0005303', 'lbl': 'Aortic arch calcification', 'desc': 'label: Aortic arch calcification\ndefinition : Calcification, that is, pathological deposition of calcium salts in the arch of aorta.\nsynonyms :\n'}


{'id': 'HP_0005304', 'url': 'http://purl.obolibrary.org/obo/HP_0005304', 'lbl': 'Hypoplastic pulmonary veins', 'desc': 'label: Hypoplastic pulmonary veins\ndefinition : \nsynonyms :Underdeveloped lung veins\n'}


{'id': 'HP_0005305', 'url': 'http://purl.obolibrary.org/obo/HP_0005305', 'lbl': 'Cerebral venous thrombosis', 'desc': 'label: Cerebral venous thrombosis\ndefinition : Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow.\nsynonyms :Blood clot in cerebral vein; Cerebral thrombosis; Cerebral vein thrombosis\n'}


{'id': 'HP_0005306', 'url': 'http://purl.obolibrary.org/obo/HP_0005306', 'lbl': 'Capillary hemangioma', 'desc': 'label: Capillary hemangioma\ndefinition : The presence of a capillary hemangioma, which are hemangiomas with small endothelial spaces.\nsynonyms :Capillary hemangiomata; Strawberry birthmark\n'}


{'id': 'HP_0005307', 'url': 'http://purl.obolibrary.org/obo/HP_0005307', 'lbl': 'Postural hypotension with compensatory tachycardia', 'desc': 'label: Postural hypotension with compensatory tachycardia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005308', 'url': 'http://purl.obolibrary.org/obo/HP_0005308', 'lbl': 'Pulmonary artery vasoconstriction', 'desc': 'label: Pulmonary artery vasoconstriction\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005309', 'url': 'http://purl.obolibrary.org/obo/HP_0005309', 'lbl': 'obsolete Peripheral vascular insufficiency', 'desc': 'label: obsolete Peripheral vascular insufficiency\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005310', 'url': 'http://purl.obolibrary.org/obo/HP_0005310', 'lbl': 'Large vessel vasculitis', 'desc': 'label: Large vessel vasculitis\ndefinition : A type of vasculitis (inflammation of blood vessel walls) affecting large arteries such as the aorta and branches of the aorta.\nsynonyms :\n'}


{'id': 'HP_0005311', 'url': 'http://purl.obolibrary.org/obo/HP_0005311', 'lbl': 'Agenesis of pulmonary vessels', 'desc': 'label: Agenesis of pulmonary vessels\ndefinition : A developmental defect characterized by the lack of formation of the pulmonary blood vessels.\nsynonyms :Absent lung vessels\n'}


{'id': 'HP_0005312', 'url': 'http://purl.obolibrary.org/obo/HP_0005312', 'lbl': 'Pulmonary aterial intimal fibrosis', 'desc': 'label: Pulmonary aterial intimal fibrosis\ndefinition : Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries in the pulmonary circulation.\nsynonyms :\n'}


{'id': 'HP_0005313', 'url': 'http://purl.obolibrary.org/obo/HP_0005313', 'lbl': 'Arterial fibromuscular dysplasia', 'desc': 'label: Arterial fibromuscular dysplasia\ndefinition : An arterial lesion that is characterized by either intimal fibroplasia, with neointimal lesions of cells and matrix deposition, or medial fibroplasia, in which there is loss of smooth muscle cells and increased deposition of collagen and proteoglycans in the medial layer.\nsynonyms :\n'}


{'id': 'HP_0005314', 'url': 'http://purl.obolibrary.org/obo/HP_0005314', 'lbl': 'Anomalous branches of internal carotid artery', 'desc': 'label: Anomalous branches of internal carotid artery\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005315', 'url': 'http://purl.obolibrary.org/obo/HP_0005315', 'lbl': 'obsolete Peripheral artery occlusive disease', 'desc': 'label: obsolete Peripheral artery occlusive disease\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005316', 'url': 'http://purl.obolibrary.org/obo/HP_0005316', 'lbl': 'Peripheral pulmonary vessel aplasia', 'desc': 'label: Peripheral pulmonary vessel aplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005317', 'url': 'http://purl.obolibrary.org/obo/HP_0005317', 'lbl': 'Increased pulmonary vascular resistance', 'desc': 'label: Increased pulmonary vascular resistance\ndefinition : Pulmonary vascular resistance (PVR) more than 3 wood units, as defined by the current definition of pulmonary hypertension. 95% of individuals have a PVR of less than 2.4 wood units.\nsynonyms :\n'}


{'id': 'HP_0005318', 'url': 'http://purl.obolibrary.org/obo/HP_0005318', 'lbl': 'Cerebral vasculitis', 'desc': 'label: Cerebral vasculitis\ndefinition : Inflammation of the blood vessels within the brain.\nsynonyms :\n'}


{'id': 'HP_0005320', 'url': 'http://purl.obolibrary.org/obo/HP_0005320', 'lbl': 'Lack of facial subcutaneous fat', 'desc': 'label: Lack of facial subcutaneous fat\ndefinition : \nsynonyms :Lack of facial fat below the skin\n'}


{'id': 'HP_0005321', 'url': 'http://purl.obolibrary.org/obo/HP_0005321', 'lbl': 'Mandibulofacial dysostosis', 'desc': 'label: Mandibulofacial dysostosis\ndefinition : A type of craniofacial dysostosis associated with abnormalities of the external ears, mirognathia, macrostomia, coloboma of the lower eyelid, and cleft palate. This is a bundled term that is left in the HPO now for convenience with legacy annotations but should not be used for new annotations.\nsynonyms :Treacher Collins syndrome\n'}


{'id': 'HP_0005322', 'url': 'http://purl.obolibrary.org/obo/HP_0005322', 'lbl': 'Prominent nasal septum', 'desc': 'label: Prominent nasal septum\ndefinition : \nsynonyms :Prominent nasal septum; Prominent septum of nose; Low hanging nasal septum; Low hanging septum of nose; Visible nasal septum; Visible septum of nose\n'}


{'id': 'HP_0005323', 'url': 'http://purl.obolibrary.org/obo/HP_0005323', 'lbl': 'Hemifacial hypertrophy', 'desc': "label: Hemifacial hypertrophy\ndefinition : Unilateral overgrowth of facial tissues, including muscles, bones and skin.\nsynonyms :Enlargement of half of face; Facial hemihypertophy; Hemifacial enlargement; Hypertrophy of half of face; Increase in size of half of face; Overgrowth of half of face; Facial hemihyperplasia; Friedreich's disease\n"}


{'id': 'HP_0005324', 'url': 'http://purl.obolibrary.org/obo/HP_0005324', 'lbl': 'Disturbance of facial expression', 'desc': 'label: Disturbance of facial expression\ndefinition : An abnormality of the gestures or movements executed with the facial muscles with which emotions such as fear, joy, sadness, surprise, and disgust can be expressed.\nsynonyms :Disturbance of facial expression\n'}


{'id': 'HP_0005325', 'url': 'http://purl.obolibrary.org/obo/HP_0005325', 'lbl': 'Extension of hair growth on temples to lateral eyebrow', 'desc': 'label: Extension of hair growth on temples to lateral eyebrow\ndefinition : A pattern of hair growth in which there is hair extending from the temples to the lateral eyebrows.\nsynonyms :Unusual hairline with hair growth on temples extending to lateral eyebrow\n'}


{'id': 'HP_0005326', 'url': 'http://purl.obolibrary.org/obo/HP_0005326', 'lbl': 'Hypoplastic philtrum', 'desc': 'label: Hypoplastic philtrum\ndefinition : Underdevelopment of the philtrum.\nsynonyms :Small philtrum\n'}


{'id': 'HP_0005327', 'url': 'http://purl.obolibrary.org/obo/HP_0005327', 'lbl': 'Loss of facial expression', 'desc': 'label: Loss of facial expression\ndefinition : \nsynonyms :Loss of facial expression\n'}


{'id': 'HP_0005328', 'url': 'http://purl.obolibrary.org/obo/HP_0005328', 'lbl': 'Progeroid facial appearance', 'desc': 'label: Progeroid facial appearance\ndefinition : A degree of wrinkling of the facial skin that is more than expected for the age of the individual, leading to a prematurely aged appearance.\nsynonyms :Aged facial appearance; Premature aged appearance; Prematurely aged face; Prematurely aged facial appearance; Wizened face\n'}


{'id': 'HP_0005329', 'url': 'http://purl.obolibrary.org/obo/HP_0005329', 'lbl': 'Fixed facial expression', 'desc': 'label: Fixed facial expression\ndefinition : \nsynonyms :Fixed facial expression; Unchanging facial expression\n'}


{'id': 'HP_0005332', 'url': 'http://purl.obolibrary.org/obo/HP_0005332', 'lbl': 'Recurrent mandibular subluxations', 'desc': 'label: Recurrent mandibular subluxations\ndefinition : Recurrent partial dislocations of the mandible.\nsynonyms :\n'}


{'id': 'HP_0005335', 'url': 'http://purl.obolibrary.org/obo/HP_0005335', 'lbl': 'Sleepy facial expression', 'desc': 'label: Sleepy facial expression\ndefinition : \nsynonyms :Sleepy facial expression; Somnolent facial expression\n'}


{'id': 'HP_0005336', 'url': 'http://purl.obolibrary.org/obo/HP_0005336', 'lbl': 'Forehead hyperpigmentation', 'desc': 'label: Forehead hyperpigmentation\ndefinition : \nsynonyms :Darkening of the forehead\n'}


{'id': 'HP_0005338', 'url': 'http://purl.obolibrary.org/obo/HP_0005338', 'lbl': 'Sparse lateral eyebrow', 'desc': 'label: Sparse lateral eyebrow\ndefinition : Decreased density/number and/or decreased diameter of lateral eyebrow hairs.\nsynonyms :Lateral hypoplasia of eyebrows; Lateral thinning of eyebrows; Laterally sparse eyebrow; Laterally sparse eyebrows; Limited hair on end of eyebrow; Sparse lateral eyebrows\n'}


{'id': 'HP_0005339', 'url': 'http://purl.obolibrary.org/obo/HP_0005339', 'lbl': 'Abnormality of complement system', 'desc': 'label: Abnormality of complement system\ndefinition : An abnormality of the complement system.\nsynonyms :\n'}


{'id': 'HP_0005340', 'url': 'http://purl.obolibrary.org/obo/HP_0005340', 'lbl': 'Spastic/hyperactive bladder', 'desc': 'label: Spastic/hyperactive bladder\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005341', 'url': 'http://purl.obolibrary.org/obo/HP_0005341', 'lbl': 'Autonomic bladder dysfunction', 'desc': 'label: Autonomic bladder dysfunction\ndefinition : Abnormal bladder function (increased urge or frequency of urination or urge incontinence) resulting from abnormal functioning of the autonomic nervous system.\nsynonyms :\n'}


{'id': 'HP_0005343', 'url': 'http://purl.obolibrary.org/obo/HP_0005343', 'lbl': 'Hypoplasia of the bladder', 'desc': 'label: Hypoplasia of the bladder\ndefinition : Underdevelopment of the urinary bladder.\nsynonyms :Hypoplastic bladder; Underdeveloped bladder\n'}


{'id': 'HP_0005344', 'url': 'http://purl.obolibrary.org/obo/HP_0005344', 'lbl': 'Abnormal carotid artery morphology', 'desc': "label: Abnormal carotid artery morphology\ndefinition : Any structural abnormality of the carotid arteries, including the common carotid artery and its' arterial branches.\nsynonyms :Abnormality of the carotid arteries\n"}


{'id': 'HP_0005345', 'url': 'http://purl.obolibrary.org/obo/HP_0005345', 'lbl': 'Abnormal vena cava morphology', 'desc': 'label: Abnormal vena cava morphology\ndefinition : An abnormality of the structure of the veins that return deoxygenated blood from the body into the heart, i.e., the superior vena cava and the inferior vena cava.\nsynonyms :Abnormality of the vena cava\n'}


{'id': 'HP_0005346', 'url': 'http://purl.obolibrary.org/obo/HP_0005346', 'lbl': 'Abnormal facial expression', 'desc': 'label: Abnormal facial expression\ndefinition : \nsynonyms :Abnormal facial expression\n'}


{'id': 'HP_0005347', 'url': 'http://purl.obolibrary.org/obo/HP_0005347', 'lbl': 'Tracheal cartilaginous sleeve', 'desc': 'label: Tracheal cartilaginous sleeve\ndefinition : Tracheal cartilaginous sleeve (TCS) is a rare congenital airway malformation in which distinct tracheal rings are replaced by a continuous cartilaginous segment. Vertically fused C- or O-shaped cartilaginous rings can extend from the subglottis to the carina or bronchus with little to no pars membranacea posteriorly.\nComment:Tracheal cartilaginous sleeve has been associated with various craniosynostosis syndromes.\nsynonyms :\n'}


{'id': 'HP_0005348', 'url': 'http://purl.obolibrary.org/obo/HP_0005348', 'lbl': 'Inspiratory stridor', 'desc': 'label: Inspiratory stridor\ndefinition : Inspiratory stridor is a high pitched sound upon inspiration that is generally related to laryngeal abnormalities.\nsynonyms :\n'}


{'id': 'HP_0005349', 'url': 'http://purl.obolibrary.org/obo/HP_0005349', 'lbl': 'Hypoplasia of the epiglottis', 'desc': 'label: Hypoplasia of the epiglottis\ndefinition : Hypoplasia of the epiglottis.\nsynonyms :Hypoplastic epiglottis\n'}


{'id': 'HP_0005352', 'url': 'http://purl.obolibrary.org/obo/HP_0005352', 'lbl': 'Severe T-cell immunodeficiency', 'desc': 'label: Severe T-cell immunodeficiency\ndefinition : A primary immune deficiency that is characterized by defects or deficiencies of T-lymphocytes that causes specific susceptibility to intracellular micro-organisms.\nsynonyms :Severe T-cell immunodeficiency\n'}


{'id': 'HP_0005353', 'url': 'http://purl.obolibrary.org/obo/HP_0005353', 'lbl': 'Recurrent herpes', 'desc': 'label: Recurrent herpes\ndefinition : Increased susceptibility to herpesvirus, as manifested by recurrent episodes of herpesvirus.\nsynonyms :Susceptibility to herpesvirus\n'}


{'id': 'HP_0005354', 'url': 'http://purl.obolibrary.org/obo/HP_0005354', 'lbl': 'Lack of T cell function', 'desc': 'label: Lack of T cell function\ndefinition : Complete inability of T cells to perform their functions in cell-mediated immunity.\nsynonyms :Absent cellular immunity\n'}


{'id': 'HP_0005356', 'url': 'http://purl.obolibrary.org/obo/HP_0005356', 'lbl': 'Decreased circulating complement factor I concentration', 'desc': 'label: Decreased circulating complement factor I concentration\ndefinition : Concentration of the complement component factor I in the blood circulation below the lower limit of normal.\nsynonyms :Decreased serum complement factor I\n'}


{'id': 'HP_0005357', 'url': 'http://purl.obolibrary.org/obo/HP_0005357', 'lbl': 'Defective B cell differentiation', 'desc': 'label: Defective B cell differentiation\ndefinition : Reduced functionality of the process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.\nsynonyms :\n'}


{'id': 'HP_0005359', 'url': 'http://purl.obolibrary.org/obo/HP_0005359', 'lbl': 'Aplasia of the thymus', 'desc': 'label: Aplasia of the thymus\ndefinition : Absence of the thymus. This feature may be appreciated by the lack of a thymic shadow upon radiographic examination.\nsynonyms :Absent thymus; Athymia; Absent thymic shadow; Lack of thymic shadow\n'}


{'id': 'HP_0005360', 'url': 'http://purl.obolibrary.org/obo/HP_0005360', 'lbl': 'Susceptibility to chickenpox', 'desc': 'label: Susceptibility to chickenpox\ndefinition : Increased susceptibility to chicken pox, as manifested by recurrent episodes of chicken pox.\nsynonyms :\n'}


{'id': 'HP_0005363', 'url': 'http://purl.obolibrary.org/obo/HP_0005363', 'lbl': 'Humoral immunodeficiency', 'desc': 'label: Humoral immunodeficiency\ndefinition : A general term referring to a defect in immunity resulting from impaired antibody production.\nsynonyms :\n'}


{'id': 'HP_0005364', 'url': 'http://purl.obolibrary.org/obo/HP_0005364', 'lbl': 'obsolete Severe viral infections', 'desc': 'label: obsolete Severe viral infections\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005365', 'url': 'http://purl.obolibrary.org/obo/HP_0005365', 'lbl': 'Severe B lymphocytopenia', 'desc': 'label: Severe B lymphocytopenia\ndefinition : A severe form of B lymphocytopenia in which the count of B cells is very low or absent.\nsynonyms :Absent B cells; Absence of B cells\n'}


{'id': 'HP_0005366', 'url': 'http://purl.obolibrary.org/obo/HP_0005366', 'lbl': 'Recurrent streptococcus pneumoniae infections', 'desc': 'label: Recurrent streptococcus pneumoniae infections\ndefinition : Increased susceptibility to streptococcus pneumoniae infections as manifested by a history of recurrent infections by streptococcus pneumoniae.\nsynonyms :\n'}


{'id': 'HP_0005368', 'url': 'http://purl.obolibrary.org/obo/HP_0005368', 'lbl': 'Abnormality of humoral immunity', 'desc': 'label: Abnormality of humoral immunity\ndefinition : An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system.\nsynonyms :Defective humoral immunity\n'}


{'id': 'HP_0005369', 'url': 'http://purl.obolibrary.org/obo/HP_0005369', 'lbl': 'Decreased circulating complement factor H concentration', 'desc': 'label: Decreased circulating complement factor H concentration\ndefinition : Concentration of the complement component factor H in the blood circulation below the lower limit of normal.\nsynonyms :Decreased serum complement factor H\n'}


{'id': 'HP_0005372', 'url': 'http://purl.obolibrary.org/obo/HP_0005372', 'lbl': 'Abnormality of B cell physiology', 'desc': 'label: Abnormality of B cell physiology\ndefinition : An abnormality of the physiological functioning of B cells.\nsynonyms :Abnormality of B cell physiology; Reduced B cell function\n'}


{'id': 'HP_0005374', 'url': 'http://purl.obolibrary.org/obo/HP_0005374', 'lbl': 'Cellular immunodeficiency', 'desc': 'label: Cellular immunodeficiency\ndefinition : An immunodeficiency characterized by defective cell-mediated immunity or humoral immunity.\nsynonyms :\n'}


{'id': 'HP_0005375', 'url': 'http://purl.obolibrary.org/obo/HP_0005375', 'lbl': 'obsolete Partial cellular immunodeficiency', 'desc': 'label: obsolete Partial cellular immunodeficiency\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005376', 'url': 'http://purl.obolibrary.org/obo/HP_0005376', 'lbl': 'Recurrent Haemophilus influenzae infections', 'desc': 'label: Recurrent Haemophilus influenzae infections\ndefinition : Increased susceptibility to Haemophilus influenzae infections as manifested by recurrent episodes of infection by Haemophilus influenzae.\nsynonyms :Recurrent H. influenzae infections\n'}


{'id': 'HP_0005379', 'url': 'http://purl.obolibrary.org/obo/HP_0005379', 'lbl': 'obsolete Severe T lymphocytopenia', 'desc': 'label: obsolete Severe T lymphocytopenia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005381', 'url': 'http://purl.obolibrary.org/obo/HP_0005381', 'lbl': 'Recurrent meningococcal disease', 'desc': 'label: Recurrent meningococcal disease\ndefinition : Recurrent infections by Neisseria meningitidis (one of the most common causes of bacterial meningitis), which is also known as meningococcus.\nsynonyms :Increased susceptibility to neisseria meningitidis infections\n'}


{'id': 'HP_0005384', 'url': 'http://purl.obolibrary.org/obo/HP_0005384', 'lbl': 'Defective B cell activation', 'desc': 'label: Defective B cell activation\ndefinition : A reduced ability of a B cell to become activated, i.e., the change in morphology and behavior of\nsynonyms :\n'}


{'id': 'HP_0005386', 'url': 'http://purl.obolibrary.org/obo/HP_0005386', 'lbl': 'Recurrent protozoan infections', 'desc': 'label: Recurrent protozoan infections\ndefinition : Increased susceptibility to protozoan infections, as manifested by recurrent episodes of protozoan infection.\nsynonyms :\n'}


{'id': 'HP_0005387', 'url': 'http://purl.obolibrary.org/obo/HP_0005387', 'lbl': 'Combined immunodeficiency', 'desc': 'label: Combined immunodeficiency\ndefinition : A group of phenotypically heterogeneous genetic disorders characterized by profound deficiencies of T- and B-cell function, which predispose the patients to both infectious and noninfectious complications.\nsynonyms :\n'}


{'id': 'HP_0005389', 'url': 'http://purl.obolibrary.org/obo/HP_0005389', 'lbl': 'Depletion of components of the alternative complement pathway', 'desc': 'label: Depletion of components of the alternative complement pathway\ndefinition : An abnormal reduction in the components of the alternative complement pathway, such as the C3 protein or its cleavage products.\nsynonyms :\n'}


{'id': 'HP_0005390', 'url': 'http://purl.obolibrary.org/obo/HP_0005390', 'lbl': 'Recurrent opportunistic infections', 'desc': 'label: Recurrent opportunistic infections\ndefinition : Increased susceptibility to opportunistic infections, as manifested by recurrent episodes of infection by opportunistic agents, i.e., by microorganisms that do not usually cause disease in a healthy host, but are able to infect a host with a compromised immune system.\nsynonyms :Frequent opportunistic infections\n'}


{'id': 'HP_0005396', 'url': 'http://purl.obolibrary.org/obo/HP_0005396', 'lbl': 'Susceptibility to coronavirus 229e', 'desc': 'label: Susceptibility to coronavirus 229e\ndefinition : Increased susceptibility to coronavirus 229e, as manifested by recurrent episodes of coronavirus 229e.\nsynonyms :\n'}


{'id': 'HP_0005397', 'url': 'http://purl.obolibrary.org/obo/HP_0005397', 'lbl': 'obsolete Exaggerated cellular immune processes', 'desc': 'label: obsolete Exaggerated cellular immune processes\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005400', 'url': 'http://purl.obolibrary.org/obo/HP_0005400', 'lbl': 'Reduction of neutrophil motility', 'desc': 'label: Reduction of neutrophil motility\ndefinition : An abnormal reduction of the cell motility of neutrophils.\nsynonyms :\n'}


{'id': 'HP_0005401', 'url': 'http://purl.obolibrary.org/obo/HP_0005401', 'lbl': 'Recurrent candida infections', 'desc': 'label: Recurrent candida infections\ndefinition : An increased susceptibility to candida infections, as manifested by a history of recurrent episodes of candida infections.\nsynonyms :Frequent candida infections\n'}


{'id': 'HP_0005402', 'url': 'http://purl.obolibrary.org/obo/HP_0005402', 'lbl': 'obsolete Primary T-lymphocyte immune abnormalities', 'desc': 'label: obsolete Primary T-lymphocyte immune abnormalities\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005403', 'url': 'http://purl.obolibrary.org/obo/HP_0005403', 'lbl': 'T lymphocytopenia', 'desc': 'label: T lymphocytopenia\ndefinition : An abnormally low count of T cells.\nsynonyms :Decrease in T cell count; Decrease in T cell number; Decreased numbers of circulating T cells; Low T cell count; Reduced number of T cells\n'}


{'id': 'HP_0005404', 'url': 'http://purl.obolibrary.org/obo/HP_0005404', 'lbl': 'Increased B cell count', 'desc': 'label: Increased B cell count\ndefinition : An abnormal increase from the normal count of B cells.\nsynonyms :Increase in B cell count; Increase in B cell number; Increased number of B cells\n'}


{'id': 'HP_0005406', 'url': 'http://purl.obolibrary.org/obo/HP_0005406', 'lbl': 'Recurrent bacterial skin infections', 'desc': 'label: Recurrent bacterial skin infections\ndefinition : Increased susceptibility to bacterial infections of the skin, as manifested by recurrent episodes of infectious dermatitis.\nsynonyms :Recurrent bacterial skin infections; Recurrent cutaneous pyogenic infections; Recurrent episodes of impetigo; Recurrent episodes of infectious dermatitis; Recurrent pyogenic skin infections\n'}


{'id': 'HP_0005407', 'url': 'http://purl.obolibrary.org/obo/HP_0005407', 'lbl': 'Decreased proportion of CD4-positive helper T cells', 'desc': 'label: Decreased proportion of CD4-positive helper T cells\ndefinition : A decreased proportion of circulating CD4-positive helper T cells relative to total T cell count.\nsynonyms :Abnormality of CD4+ T cells; CD4 T cell lymphopenia; CD4+ T-cell lymphopenia\n'}


{'id': 'HP_0005409', 'url': 'http://purl.obolibrary.org/obo/HP_0005409', 'lbl': 'obsolete Markedly reduced T cell function', 'desc': 'label: obsolete Markedly reduced T cell function\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005411', 'url': 'http://purl.obolibrary.org/obo/HP_0005411', 'lbl': 'Chronic intestinal candidiasis', 'desc': 'label: Chronic intestinal candidiasis\ndefinition : Persistent overgrowth of Candida albicans in the gastrointestinal tract.\nsynonyms :Candida overgrowth syndrome\n'}


{'id': 'HP_0005413', 'url': 'http://purl.obolibrary.org/obo/HP_0005413', 'lbl': 'Increased alpha-globulin', 'desc': 'label: Increased alpha-globulin\ndefinition : An abnormally increased level of circulating alpha-globulin. Alpha globulins are a group of serum proteins defined by their mobility on serum electrophoresis. The alpha1-protein fraction is comprised of alpha1-antitrypsin, thyroid-binding globulin, and transcortin. Ceruloplasmin, alpha2-macroglobulin, and haptoglobin contribute to the alpha2-protein band. The alpha2 component is increased as an acute-phase reactant.\nsynonyms :\n'}


{'id': 'HP_0005415', 'url': 'http://purl.obolibrary.org/obo/HP_0005415', 'lbl': 'Decreased proportion of CD8-positive T cells', 'desc': 'label: Decreased proportion of CD8-positive T cells\ndefinition : A decreased proportion of circulating CD8-positive, alpha-beta T cells relative to total number of T cells.\nsynonyms :CD8+ T-cell lymphopenia; Decreased proportion of CD8+ T cells; Decreased proportion of CD8-positive, alpha-beta T cells\n'}


{'id': 'HP_0005416', 'url': 'http://purl.obolibrary.org/obo/HP_0005416', 'lbl': 'Decreased circulating complement factor B concentration', 'desc': 'label: Decreased circulating complement factor B concentration\ndefinition : Concentration of the complement component factor B in the blood circulation below the lower limit of normal.\nsynonyms :Decreased serum complement factor B; Decreased serum factor b\n'}


{'id': 'HP_0005419', 'url': 'http://purl.obolibrary.org/obo/HP_0005419', 'lbl': 'Decreased T cell activation', 'desc': 'label: Decreased T cell activation\ndefinition : Decreased or impaired activation of T cells in response to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.\nsynonyms :Decreased T lymphocyte activation; Decreased T-cell activation; Decreased T-lymphocyte activation; Defective T cell activation; Profound depletion of T4+ lymphocytes\n'}


{'id': 'HP_0005420', 'url': 'http://purl.obolibrary.org/obo/HP_0005420', 'lbl': 'Recurrent gram-negative bacterial infections', 'desc': 'label: Recurrent gram-negative bacterial infections\ndefinition : Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents.\nsynonyms :\n'}


{'id': 'HP_0005421', 'url': 'http://purl.obolibrary.org/obo/HP_0005421', 'lbl': 'Decreased circulating complement C3 concentration', 'desc': 'label: Decreased circulating complement C3 concentration\ndefinition : Concentration of the complement component C3 in the blood circulation below the lower limit of normal.\nsynonyms :Decreased serum C3; Decreased serum complement C3; Decreased serum complement C3 level\n'}


{'id': 'HP_0005422', 'url': 'http://purl.obolibrary.org/obo/HP_0005422', 'lbl': 'Absence of CD8-positive T cells', 'desc': 'label: Absence of CD8-positive T cells\ndefinition : Lack of detectible CD8-positive T cells\nsynonyms :Absence of CD8+ T cells\n'}


{'id': 'HP_0005423', 'url': 'http://purl.obolibrary.org/obo/HP_0005423', 'lbl': 'Dysfunctional alternative complement pathway', 'desc': 'label: Dysfunctional alternative complement pathway\ndefinition : An abnormality of the functioning of any aspect of the alternative complement pathway.\nsynonyms :\n'}


{'id': 'HP_0005424', 'url': 'http://purl.obolibrary.org/obo/HP_0005424', 'lbl': 'Absent specific antibody response', 'desc': 'label: Absent specific antibody response\ndefinition : Absence of specific immunoglobulins directed against a specific antigen or microorganism.\nsynonyms :\n'}


{'id': 'HP_0005425', 'url': 'http://purl.obolibrary.org/obo/HP_0005425', 'lbl': 'Recurrent sinopulmonary infections', 'desc': 'label: Recurrent sinopulmonary infections\ndefinition : An increased susceptibility to infections involving both the paranasal sinuses and the lungs, as manifested by a history of recurrent sinopulmonary infections.\nsynonyms :Chronic sinopulmonary infection; Recurrent sinus and lung infections\n'}


{'id': 'HP_0005428', 'url': 'http://purl.obolibrary.org/obo/HP_0005428', 'lbl': 'Severe recurrent varicella', 'desc': 'label: Severe recurrent varicella\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005429', 'url': 'http://purl.obolibrary.org/obo/HP_0005429', 'lbl': 'Recurrent systemic pyogenic infections', 'desc': 'label: Recurrent systemic pyogenic infections\ndefinition : Increased susceptibility to systemic pyogenic infections, as manifested by recurrent episodes of systemic pyogenic infections.\nsynonyms :\n'}


{'id': 'HP_0005430', 'url': 'http://purl.obolibrary.org/obo/HP_0005430', 'lbl': 'Recurrent Neisserial infections', 'desc': 'label: Recurrent Neisserial infections\ndefinition : Recurrent infections by bacteria of the genus Neisseria, including N. meningitidis (one of the most common causes of bacterial meningitis).\nsynonyms :Episodes of neisserial infection; Recurrent neisseria infections\n'}


{'id': 'HP_0005432', 'url': 'http://purl.obolibrary.org/obo/HP_0005432', 'lbl': 'Transient hypogammaglobulinemia of infancy', 'desc': 'label: Transient hypogammaglobulinemia of infancy\ndefinition : At birth, newborns are endowed with maternal antibodies. IgG production normally begins at the age of two months. A delay in recovery from this physiological hypogammaglobulinemia between the 3rd and the 6th month of life, and of recovery period between 18 and 36 months defines transient newborn hypogammaglobulinemia.\nsynonyms :Newborn gammaglobulin deficiency\n'}


{'id': 'HP_0005435', 'url': 'http://purl.obolibrary.org/obo/HP_0005435', 'lbl': 'Impaired T cell function', 'desc': 'label: Impaired T cell function\ndefinition : Abnormally reduced ability of T cells to perform their functions in cell-mediated immunity.\nsynonyms :Impaired T cell function; T-cell dysfunction\n'}


{'id': 'HP_0005437', 'url': 'http://purl.obolibrary.org/obo/HP_0005437', 'lbl': 'Recurrent infections in infancy and early childhood', 'desc': 'label: Recurrent infections in infancy and early childhood\ndefinition : Recurrent infections at an early age with improvement in later childhood.\nsynonyms :\n'}


{'id': 'HP_0005439', 'url': 'http://purl.obolibrary.org/obo/HP_0005439', 'lbl': 'Maxillozygomatic hypoplasia', 'desc': 'label: Maxillozygomatic hypoplasia\ndefinition : Hypoplasia of the maxillozygomatic complex.\nsynonyms :Decreased size of zygomaticomaxillary bone complex; Deficiency of zygomaticomaxillary bone complex; Hypoplasia of malar bone complex; Hypoplasia of zygomaticomaxillary complex; Underdevelopment of zygomaticomaxillary bone complex; Decreased projection of zygomaticomaxillary bone complex\n'}


{'id': 'HP_0005441', 'url': 'http://purl.obolibrary.org/obo/HP_0005441', 'lbl': 'Sclerotic cranial sutures', 'desc': 'label: Sclerotic cranial sutures\ndefinition : An increased density in the cranial sutures following obliteration.\nsynonyms :\n'}


{'id': 'HP_0005442', 'url': 'http://purl.obolibrary.org/obo/HP_0005442', 'lbl': 'Widely patent coronal suture', 'desc': 'label: Widely patent coronal suture\ndefinition : The presence of a coronal suture (the cranial suture that separates the frontal and parietal bones) that is not ossified but rather wide open at an age when it is normally closed.\nsynonyms :\n'}


{'id': 'HP_0005445', 'url': 'http://purl.obolibrary.org/obo/HP_0005445', 'lbl': 'Enlarged posterior fossa', 'desc': 'label: Enlarged posterior fossa\ndefinition : Abnormal increased size of the posterior cranial fossa.\nsynonyms :Widened posterior fossa\n'}


{'id': 'HP_0005446', 'url': 'http://purl.obolibrary.org/obo/HP_0005446', 'lbl': 'Obtuse angle of mandible', 'desc': 'label: Obtuse angle of mandible\ndefinition : Abnormally flat (obtuse) angle of the mandible. The angle of the mandibular, located at the junction between the body and the ramus of the mandible, is normally close to being a right angle. This terms describes an abnormal increase of this angle such that the mandible appears flatter than normal.\nsynonyms :High mandibular plane angle; Steep mandibular plane angle\n'}


{'id': 'HP_0005449', 'url': 'http://purl.obolibrary.org/obo/HP_0005449', 'lbl': 'Bridged sella turcica', 'desc': 'label: Bridged sella turcica\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005450', 'url': 'http://purl.obolibrary.org/obo/HP_0005450', 'lbl': 'Calvarial osteosclerosis', 'desc': 'label: Calvarial osteosclerosis\ndefinition : An increase in bone density affecting the calvaria (roof of the skull).\nsynonyms :\n'}


{'id': 'HP_0005451', 'url': 'http://purl.obolibrary.org/obo/HP_0005451', 'lbl': 'Decreased cranial base ossification', 'desc': 'label: Decreased cranial base ossification\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005453', 'url': 'http://purl.obolibrary.org/obo/HP_0005453', 'lbl': 'Absent/hypoplastic paranasal sinuses', 'desc': 'label: Absent/hypoplastic paranasal sinuses\ndefinition : Aplasia or hypoplasia of the paranasal sinuses.\nsynonyms :\n'}


{'id': 'HP_0005456', 'url': 'http://purl.obolibrary.org/obo/HP_0005456', 'lbl': 'Absent ethmoidal sinuses', 'desc': 'label: Absent ethmoidal sinuses\ndefinition : Lack (aplasia) of the ethmoidal sinus.\nsynonyms :Agenesis of ethmoid sinuses; Failure of development of ethmoid sinuses; Missing ethmoid sinuses\n'}


{'id': 'HP_0005458', 'url': 'http://purl.obolibrary.org/obo/HP_0005458', 'lbl': 'Premature closure of fontanelles', 'desc': 'label: Premature closure of fontanelles\ndefinition : Normally, the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior fontanelle closes by about the middle of the second year. This term refers to the situation in which the fontanelles close at an inappropriately early time point.\nsynonyms :Early closure of the cranial sutures; Premature closure of the cranial sutures; Early closure of the fontanelles; Obliterated fontanelles; Early closure of the bregma sutures; Premature closure of the bregma sutures\n'}


{'id': 'HP_0005461', 'url': 'http://purl.obolibrary.org/obo/HP_0005461', 'lbl': 'Craniofacial disproportion', 'desc': 'label: Craniofacial disproportion\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005462', 'url': 'http://purl.obolibrary.org/obo/HP_0005462', 'lbl': 'Calcification of falx cerebri', 'desc': 'label: Calcification of falx cerebri\ndefinition : The presence of calcium deposition in the falx cerebri.\nsynonyms :\n'}


{'id': 'HP_0005463', 'url': 'http://purl.obolibrary.org/obo/HP_0005463', 'lbl': 'Elongated sella turcica', 'desc': 'label: Elongated sella turcica\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005464', 'url': 'http://purl.obolibrary.org/obo/HP_0005464', 'lbl': 'Craniofacial osteosclerosis', 'desc': 'label: Craniofacial osteosclerosis\ndefinition : Abnormally increased density of craniofacial bone tissue.\nsynonyms :Cranial sclerosis\n'}


{'id': 'HP_0005465', 'url': 'http://purl.obolibrary.org/obo/HP_0005465', 'lbl': 'Facial hyperostosis', 'desc': 'label: Facial hyperostosis\ndefinition : Excessive growth (overgrowth) of the facial bones, that is of the facial skeleton.\nsynonyms :Enlargement of facial bones; Enlargement of facial skeleton; Hypertrophy of facial bones; Hypertrophy of facial skeleton; Enlargment of the facial bones; Excessive growth of facial bones; Excessive growth of facial skeleton; Hyperostosis of facial bones; Hyperostosis of facial skeleton; Hypertrophy of the facial bones; Increase in size of the facial bones; Overgrowth of facial bones; Overgrowth of facial skeleton; Overgrowth of the facial bones; Increased ossification of facial bones; Increased ossification of facial skeleton\n'}


{'id': 'HP_0005466', 'url': 'http://purl.obolibrary.org/obo/HP_0005466', 'lbl': 'Hypoplasia of the frontal bone', 'desc': 'label: Hypoplasia of the frontal bone\ndefinition : Underdevelopment of the frontal bone.\nsynonyms :Decreased size of bone of forehead; Hypoplastic frontal bones; Small bone of forehead; Underdevelopment of bone of forehead; Hypotrophic frontal bone; Hypotrophic frontal bones; Thin bone of forehead\n'}


{'id': 'HP_0005469', 'url': 'http://purl.obolibrary.org/obo/HP_0005469', 'lbl': 'Flat occiput', 'desc': 'label: Flat occiput\ndefinition : Reduced convexity of the occiput (posterior part of skull).\nsynonyms :Flat back of skull; Flat back of the head; Flat back of the skull; Flat posterior head; Flat posterior cranium; Posterior flattening of the skull\n'}


{'id': 'HP_0005472', 'url': 'http://purl.obolibrary.org/obo/HP_0005472', 'lbl': 'Orbital craniosynostosis', 'desc': 'label: Orbital craniosynostosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005473', 'url': 'http://purl.obolibrary.org/obo/HP_0005473', 'lbl': 'Fusion of middle ear ossicles', 'desc': 'label: Fusion of middle ear ossicles\ndefinition : Bony fusion of malleus, incus, and stapes.\nsynonyms :\n'}


{'id': 'HP_0005474', 'url': 'http://purl.obolibrary.org/obo/HP_0005474', 'lbl': 'Decreased calvarial ossification', 'desc': 'label: Decreased calvarial ossification\ndefinition : Abnormal reduction in ossification of the calvaria (roof of the skull consisting of the frontal bone, parietal bones, temporal bones, and occipital bone).\nsynonyms :Poorly ossified calvaria; Poorly ossified calvarium; Soft calvaria; Soft skullcap; Undermineralized calvarium; Skull soft on palpation\n'}


{'id': 'HP_0005476', 'url': 'http://purl.obolibrary.org/obo/HP_0005476', 'lbl': 'Widely patent sagittal suture', 'desc': 'label: Widely patent sagittal suture\ndefinition : The presence of a sagittal suture (the cranial suture that separates the left and right parietal bones) that is not ossified but rather wide open at an age when it is normally closed.\nsynonyms :\n'}


{'id': 'HP_0005477', 'url': 'http://purl.obolibrary.org/obo/HP_0005477', 'lbl': 'Progressive sclerosis of skull base', 'desc': 'label: Progressive sclerosis of skull base\ndefinition : Progressively increasing bone density of the skull base without significant changes in bony contour.\nsynonyms :\n'}


{'id': 'HP_0005478', 'url': 'http://purl.obolibrary.org/obo/HP_0005478', 'lbl': 'Prominent frontal sinuses', 'desc': 'label: Prominent frontal sinuses\ndefinition : \nsynonyms :Large frontal sinus; Hyperplasia of frontal sinus; Hypertrophy of frontal sinus; Increased size of frontal sinus; Increased volume of frontal sinus\n'}


{'id': 'HP_0005479', 'url': 'http://purl.obolibrary.org/obo/HP_0005479', 'lbl': 'Decreased circulating IgE', 'desc': 'label: Decreased circulating IgE\ndefinition : An abnormally decreased level of immunoglobulin E (IgE) in blood.\nsynonyms :Decreased IgE; IgE deficiency\n'}


{'id': 'HP_0005482', 'url': 'http://purl.obolibrary.org/obo/HP_0005482', 'lbl': 'Abnormality of the alternative complement pathway', 'desc': 'label: Abnormality of the alternative complement pathway\ndefinition : A deviation in any aspect of the alternative complement pathway.\nsynonyms :\n'}


{'id': 'HP_0005483', 'url': 'http://purl.obolibrary.org/obo/HP_0005483', 'lbl': 'Abnormal epiglottis morphology', 'desc': 'label: Abnormal epiglottis morphology\ndefinition : An abnormality of the epiglottis.\nsynonyms :Abnormality of the epiglottis\n'}


{'id': 'HP_0005484', 'url': 'http://purl.obolibrary.org/obo/HP_0005484', 'lbl': 'Secondary microcephaly', 'desc': 'label: Secondary microcephaly\ndefinition : Head circumference which falls below 2 standard deviations below the mean for age and gender because of insufficient head growth after birth.\nsynonyms :Development of small head that was not present at birth; Acquired microcephaly; Deceleration of head growth; Microcephaly, acquired; Microcephaly, postnatal; Postnatal deceleration of head circumference; Postnatal microcephaly\n'}


{'id': 'HP_0005486', 'url': 'http://purl.obolibrary.org/obo/HP_0005486', 'lbl': 'Small fontanelle', 'desc': 'label: Small fontanelle\ndefinition : A fontanelle that is small for age.\nsynonyms :Little cranial sutures; Small cranial sutures; Little fontanelle; Microfontanelle; Small soft spot; Small bregma sutures\n'}


{'id': 'HP_0005487', 'url': 'http://purl.obolibrary.org/obo/HP_0005487', 'lbl': 'Prominent metopic ridge', 'desc': 'label: Prominent metopic ridge\ndefinition : Vertical bony ridge positioned in the midline of the forehead.\nsynonyms :Prominent frontal ridge; Prominent metopic suture; Ridging of metopic suture; Prominent frontal suture; Ridging of frontal suture\n'}


{'id': 'HP_0005490', 'url': 'http://purl.obolibrary.org/obo/HP_0005490', 'lbl': 'Postnatal macrocephaly', 'desc': 'label: Postnatal macrocephaly\ndefinition : The postnatal development of an abnormally large skull (macrocephaly).\nsynonyms :Macrocephaly, postnatal\n'}


{'id': 'HP_0005494', 'url': 'http://purl.obolibrary.org/obo/HP_0005494', 'lbl': 'Premature posterior fontanelle closure', 'desc': 'label: Premature posterior fontanelle closure\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005495', 'url': 'http://purl.obolibrary.org/obo/HP_0005495', 'lbl': 'Metopic suture patent to nasal root', 'desc': 'label: Metopic suture patent to nasal root\ndefinition : The frontal suture divides the two halves of the frontal bone in infants and usually fuses by the age of six years. The suture runs from the bregma (the point on the skull at which the coronal suture is intersected perpendicularly by the sagittal suture) to the nasion or nasal root. This term applies if the suture is widely patent from bregma to nasal root.\nsynonyms :\n'}


{'id': 'HP_0005498', 'url': 'http://purl.obolibrary.org/obo/HP_0005498', 'lbl': 'Midline skin dimples over anterior/posterior fontanelles', 'desc': 'label: Midline skin dimples over anterior/posterior fontanelles\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005502', 'url': 'http://purl.obolibrary.org/obo/HP_0005502', 'lbl': 'Increased red cell osmotic fragility', 'desc': 'label: Increased red cell osmotic fragility\ndefinition : \nsynonyms :Increased erythrocyte osmotic fragility; Increased red cell fragility\n'}


{'id': 'HP_0005505', 'url': 'http://purl.obolibrary.org/obo/HP_0005505', 'lbl': 'Refractory anemia', 'desc': 'label: Refractory anemia\ndefinition : \nsynonyms :Refractory anaemia\n'}


{'id': 'HP_0005506', 'url': 'http://purl.obolibrary.org/obo/HP_0005506', 'lbl': 'Chronic myelogenous leukemia', 'desc': 'label: Chronic myelogenous leukemia\ndefinition : A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate.\nsynonyms :Chronic myelocytic leukaemia; Chronic myelocytic leukemia; Chronic myelogenous leukaemia; Chronic myeloid leukaemia; Chronic myeloid leukemia\n'}


{'id': 'HP_0005507', 'url': 'http://purl.obolibrary.org/obo/HP_0005507', 'lbl': 'Hemoglobin Barts', 'desc': 'label: Hemoglobin Barts\ndefinition : Normal adult hemoglobin is composed of two chains each of alpha and beta globin. Hb Barts (Hemoglobin Barts) is a tetramer with four gamma globin chains, and is essentially pathognomonic for one or another form of alpha thalassemia. Hb Barts has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues.\nsynonyms :Haemoglobin Barts; Hb Barts\n'}


{'id': 'HP_0005508', 'url': 'http://purl.obolibrary.org/obo/HP_0005508', 'lbl': 'Monoclonal immunoglobulin M proteinemia', 'desc': 'label: Monoclonal immunoglobulin M proteinemia\ndefinition : Presence of a monoclonal immunoglobulin M protein in the serum.\nsynonyms :Waldenstrom macroglobulinemia\n'}


{'id': 'HP_0005510', 'url': 'http://purl.obolibrary.org/obo/HP_0005510', 'lbl': 'Transient erythroblastopenia', 'desc': 'label: Transient erythroblastopenia\ndefinition : A transient reduction in the number of erythroblasts in the circulation.\nsynonyms :Transient decrease in blood erythrocyte number\n'}


{'id': 'HP_0005511', 'url': 'http://purl.obolibrary.org/obo/HP_0005511', 'lbl': 'Heinz body anemia', 'desc': 'label: Heinz body anemia\ndefinition : Anemia characterized by abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells.\nsynonyms :Heinz body anaemia\n'}


{'id': 'HP_0005512', 'url': 'http://purl.obolibrary.org/obo/HP_0005512', 'lbl': 'Impaired neutrophil killing of staphylococci', 'desc': 'label: Impaired neutrophil killing of staphylococci\ndefinition : A reduction in the ability of neutrophils to kill the gram-positive bacteria, staphylococcus, which is commonly known as staph.\nsynonyms :\n'}


{'id': 'HP_0005513', 'url': 'http://purl.obolibrary.org/obo/HP_0005513', 'lbl': 'Increased megakaryocyte count', 'desc': 'label: Increased megakaryocyte count\ndefinition : Increased megakaryocyte number, i.e., of platelet precursor cells, present in the bone marrow.\nsynonyms :\n'}


{'id': 'HP_0005517', 'url': 'http://purl.obolibrary.org/obo/HP_0005517', 'lbl': 'T-cell lymphoma/leukemia', 'desc': 'label: T-cell lymphoma/leukemia\ndefinition : A type of T-cell lymphoma in which cancerous T-cells may present in the blood (leukemia), lymph nodes (lymphoma), skin or in multiple areas.\nsynonyms :\n'}


{'id': 'HP_0005518', 'url': 'http://purl.obolibrary.org/obo/HP_0005518', 'lbl': 'Increased mean corpuscular volume', 'desc': 'label: Increased mean corpuscular volume\ndefinition : Larger than normal size of erythrocytes.\nsynonyms :Erythrocyte macrocytosis; Increased MCV\n'}


{'id': 'HP_0005520', 'url': 'http://purl.obolibrary.org/obo/HP_0005520', 'lbl': 'Chronic disseminated intravascular coagulation', 'desc': 'label: Chronic disseminated intravascular coagulation\ndefinition : A chronic form of disseminated intravascular coagulation in which a persistent weak or intermittent activating stimulus is present and destruction and production of coagulation factors and platelets are balanced.\nsynonyms :Chronic consumption coagulopathy; Compensated disseminated intravascular coagulation\n'}


{'id': 'HP_0005521', 'url': 'http://purl.obolibrary.org/obo/HP_0005521', 'lbl': 'Disseminated intravascular coagulation', 'desc': 'label: Disseminated intravascular coagulation\ndefinition : Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels.\nsynonyms :\n'}


{'id': 'HP_0005522', 'url': 'http://purl.obolibrary.org/obo/HP_0005522', 'lbl': 'Pyridoxine-responsive sideroblastic anemia', 'desc': 'label: Pyridoxine-responsive sideroblastic anemia\ndefinition : A type of sideroblastic anemia that is alleviated by pyridoxine (vitamin B-6) treatment.\nsynonyms :Pyridoxine-responsive sideroblastic anaemia\n'}


{'id': 'HP_0005523', 'url': 'http://purl.obolibrary.org/obo/HP_0005523', 'lbl': 'Lymphoproliferative disorder', 'desc': 'label: Lymphoproliferative disorder\ndefinition : \nsynonyms :Lymphoproliferative disorders\n'}


{'id': 'HP_0005524', 'url': 'http://purl.obolibrary.org/obo/HP_0005524', 'lbl': 'Macrocytic hemolytic disease', 'desc': 'label: Macrocytic hemolytic disease\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005525', 'url': 'http://purl.obolibrary.org/obo/HP_0005525', 'lbl': 'Spontaneous hemolytic crises', 'desc': 'label: Spontaneous hemolytic crises\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005526', 'url': 'http://purl.obolibrary.org/obo/HP_0005526', 'lbl': 'Lymphoid leukemia', 'desc': 'label: Lymphoid leukemia\ndefinition : A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias.\nsynonyms :Lymphoid leukaemia\n'}


{'id': 'HP_0005527', 'url': 'http://purl.obolibrary.org/obo/HP_0005527', 'lbl': 'Reduced kininogen activity', 'desc': 'label: Reduced kininogen activity\ndefinition : Reduction in the amount of kininogen, which functions as a cofactor in the contact phase of the intrinsic blood coagulation cascade.\nsynonyms :Fitzgerald factor deficiency; Kininogen deficiency; Williams factor deficiency; Williams-Fitzgerald-Flaujeac factor deficiency\n'}


{'id': 'HP_0005528', 'url': 'http://purl.obolibrary.org/obo/HP_0005528', 'lbl': 'Bone marrow hypocellularity', 'desc': 'label: Bone marrow hypocellularity\ndefinition : A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.\nsynonyms :Bone marrow failure; Bone marrow hypoplasia; Hypoplastic bone marrow\n'}


{'id': 'HP_0005531', 'url': 'http://purl.obolibrary.org/obo/HP_0005531', 'lbl': 'Biphenotypic acute leukemia', 'desc': 'label: Biphenotypic acute leukemia\ndefinition : A type of actue leukemia with features characteristic of both the myeloid and lymphoid lineages. These leukemias are for this reason are designated mixed-lineage, hybrid or biphenotypic acute leukemias.\nsynonyms :Acute biphenotypic leukaemia; Biphenotypic acute leukaemia; Myeloid/lymphoid leukaemia; Myeloid/lymphoid leukemia\n'}


{'id': 'HP_0005532', 'url': 'http://purl.obolibrary.org/obo/HP_0005532', 'lbl': 'Macrocytic dyserythropoietic anemia', 'desc': 'label: Macrocytic dyserythropoietic anemia\ndefinition : \nsynonyms :Macrocytic dyserythropoietic anaemia\n'}


{'id': 'HP_0005534', 'url': 'http://purl.obolibrary.org/obo/HP_0005534', 'lbl': 'Transient myeloproliferative syndrome', 'desc': 'label: Transient myeloproliferative syndrome\ndefinition : A unique clonal neoplastic disorder that is linked to trisomy 21, is restricted to neonatal period, and spontaneously regresses. It often has characteristics of megakaryocytic lineage and is associated with GATA1 mutations in myeloblasts.\nsynonyms :TMD; Transient leukaemia of Down syndrome; Transient leukemia of Down syndrome; Transient myeloproliferative disorder\n'}


{'id': 'HP_0005535', 'url': 'http://purl.obolibrary.org/obo/HP_0005535', 'lbl': 'Exercise-induced hemolysis', 'desc': 'label: Exercise-induced hemolysis\ndefinition : A form of hemolytic anemia that can be triggered by exertion.\nsynonyms :\n'}


{'id': 'HP_0005537', 'url': 'http://purl.obolibrary.org/obo/HP_0005537', 'lbl': 'Decreased mean platelet volume', 'desc': 'label: Decreased mean platelet volume\ndefinition : Average platelet volume below the lower limit of the normal reference interval.\nsynonyms :Small platelet size; Small platelets; Small platelets size\n'}


{'id': 'HP_0005539', 'url': 'http://purl.obolibrary.org/obo/HP_0005539', 'lbl': 'T cell chronic lymphocytic lymphoma/leukemia', 'desc': 'label: T cell chronic lymphocytic lymphoma/leukemia\ndefinition : A form of lymphoid leukemia or lymphoma in which too many T-cell lymphoblasts are found in the blood, bone marrow, and tissues. Leukemia or lymphoma classification depends on which feature is more prominent.\nsynonyms :\n'}


{'id': 'HP_0005540', 'url': 'http://purl.obolibrary.org/obo/HP_0005540', 'lbl': 'Red blood cell keratocytosis', 'desc': 'label: Red blood cell keratocytosis\ndefinition : A form of poikilocytosis in which the abnormally shaped erythrocytes have notches that results in projections that look like horns.\nsynonyms :Distorted red blood cells resembling keratocytes; RBC keratocytosis\n'}


{'id': 'HP_0005541', 'url': 'http://purl.obolibrary.org/obo/HP_0005541', 'lbl': 'Congenital agranulocytosis', 'desc': 'label: Congenital agranulocytosis\ndefinition : Congenital onset of a marked decrease in the number of granulocytes.\nsynonyms :\n'}


{'id': 'HP_0005542', 'url': 'http://purl.obolibrary.org/obo/HP_0005542', 'lbl': 'Prolonged whole-blood clotting time', 'desc': 'label: Prolonged whole-blood clotting time\ndefinition : An abnormal prolongation (delay) in the time required by whole blood to produce a visible clot.\nsynonyms :Prolonged clotting time\n'}


{'id': 'HP_0005543', 'url': 'http://purl.obolibrary.org/obo/HP_0005543', 'lbl': 'Reduced protein C activity', 'desc': 'label: Reduced protein C activity\ndefinition : An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein C. Protein C is activated to protein Ca by thrombin bound to thrombomodulin. Activated protein C degrades factors VIIIa and Va.\nsynonyms :Protein C deficiency\n'}


{'id': 'HP_0005546', 'url': 'http://purl.obolibrary.org/obo/HP_0005546', 'lbl': 'Increased red cell osmotic resistance', 'desc': 'label: Increased red cell osmotic resistance\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005547', 'url': 'http://purl.obolibrary.org/obo/HP_0005547', 'lbl': 'Myeloproliferative disorder', 'desc': 'label: Myeloproliferative disorder\ndefinition : Proliferation (excess production) of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential.\nsynonyms :\n'}


{'id': 'HP_0005548', 'url': 'http://purl.obolibrary.org/obo/HP_0005548', 'lbl': 'Megakaryocytopenia', 'desc': 'label: Megakaryocytopenia\ndefinition : A reduced count of megakaryocytes.\nsynonyms :\n'}


{'id': 'HP_0005549', 'url': 'http://purl.obolibrary.org/obo/HP_0005549', 'lbl': 'obsolete Congenital neutropenia', 'desc': 'label: obsolete Congenital neutropenia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005550', 'url': 'http://purl.obolibrary.org/obo/HP_0005550', 'lbl': 'Chronic lymphatic leukemia', 'desc': 'label: Chronic lymphatic leukemia\ndefinition : A chronic lymphocytic/lymphatic/lymphoblastic leukemia (CLL) is a neoplastic disease characterized by proliferation and accumulation (blood, marrow and lymphoid organs) of morphologically mature but immunologically dysfunctional lymphocytes. A CLL is always a B-cell lymphocytic leukemia as there are no reports of cases of T-cell lymphocytic leukemias.\nsynonyms :Chronic lymphatic leukaemia; Chronic lymphocytic leukaemia; Chronic lymphocytic leukemia\n'}


{'id': 'HP_0005556', 'url': 'http://purl.obolibrary.org/obo/HP_0005556', 'lbl': 'Abnormality of the metopic suture', 'desc': 'label: Abnormality of the metopic suture\ndefinition : The frontal suture divides the two halves of the frontal bone of the skull in infants and children and generally undergoes fusion by the age of six. A persistent frontal suture is referred to as a "metopic suture".\nsynonyms :\n'}


{'id': 'HP_0005557', 'url': 'http://purl.obolibrary.org/obo/HP_0005557', 'lbl': 'Abnormal zygomatic arch morphology', 'desc': 'label: Abnormal zygomatic arch morphology\ndefinition : An abnormality of the zygomatic arch, also known as the cheek bone.\nsynonyms :Abnormality of the malar arch; Abnormality of the zygomatic arch; Anomaly of the malar arch; Anomaly of the zygomatic arch; Deformity of the malar arch; Deformity of the zygomatic arch; Malformation of the malar arch; Malformation of the zygomatic arch\n'}


{'id': 'HP_0005558', 'url': 'http://purl.obolibrary.org/obo/HP_0005558', 'lbl': 'Chronic leukemia', 'desc': 'label: Chronic leukemia\ndefinition : A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia.\nsynonyms :Chronic blood cancer; Chronic leukaemia\n'}


{'id': 'HP_0005559', 'url': 'http://purl.obolibrary.org/obo/HP_0005559', 'lbl': 'Abnormality of the kinin-kallikrein system', 'desc': 'label: Abnormality of the kinin-kallikrein system\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005560', 'url': 'http://purl.obolibrary.org/obo/HP_0005560', 'lbl': 'Imbalanced hemoglobin synthesis', 'desc': 'label: Imbalanced hemoglobin synthesis\ndefinition : Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia.\nsynonyms :Imbalanced Hb synthesis; Imbalanced haemoglobin synthesis\n'}


{'id': 'HP_0005561', 'url': 'http://purl.obolibrary.org/obo/HP_0005561', 'lbl': 'Abnormality of bone marrow cell morphology', 'desc': 'label: Abnormality of bone marrow cell morphology\ndefinition : An anomaly of the form or number of cells in the bone marrow.\nsynonyms :Anomaly of the bone marrow cells; Bone marrow disease\n'}


{'id': 'HP_0005562', 'url': 'http://purl.obolibrary.org/obo/HP_0005562', 'lbl': 'Multiple renal cysts', 'desc': 'label: Multiple renal cysts\ndefinition : The presence of many cysts in the kidney.\nsynonyms :Multiple kidney cysts\n'}


{'id': 'HP_0005563', 'url': 'http://purl.obolibrary.org/obo/HP_0005563', 'lbl': 'Decreased numbers of nephrons', 'desc': 'label: Decreased numbers of nephrons\ndefinition : A reduction in the count of nephrons per kidney.\nsynonyms :Oligonephronia; Decreased numbers of glomeruli\n'}


{'id': 'HP_0005564', 'url': 'http://purl.obolibrary.org/obo/HP_0005564', 'lbl': 'Absence of renal corticomedullary differentiation', 'desc': 'label: Absence of renal corticomedullary differentiation\ndefinition : A lack of differentiation between renal cortex and medulla on diagnostic imaging.\nsynonyms :Absent renal corticomedullary differentiation; Loss of corticomedullary differentiation\n'}


{'id': 'HP_0005565', 'url': 'http://purl.obolibrary.org/obo/HP_0005565', 'lbl': 'Reduced renal corticomedullary differentiation', 'desc': 'label: Reduced renal corticomedullary differentiation\ndefinition : Reduced differentiation between renal cortex and medulla on diagnostic imaging.\nsynonyms :Loss of definition of corticomedullary differentiation\n'}


{'id': 'HP_0005567', 'url': 'http://purl.obolibrary.org/obo/HP_0005567', 'lbl': 'Renal magnesium wasting', 'desc': 'label: Renal magnesium wasting\ndefinition : High urine magnesium in the presence of hypomagnesemia.\nsynonyms :\n'}


{'id': 'HP_0005571', 'url': 'http://purl.obolibrary.org/obo/HP_0005571', 'lbl': 'Increased renal tubular phosphate reabsorption', 'desc': 'label: Increased renal tubular phosphate reabsorption\ndefinition : \nsynonyms :Increased percent tubular reabsorption of phosphorus\n'}


{'id': 'HP_0005572', 'url': 'http://purl.obolibrary.org/obo/HP_0005572', 'lbl': 'Decreased renal tubular phosphate excretion', 'desc': 'label: Decreased renal tubular phosphate excretion\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0005574', 'url': 'http://purl.obolibrary.org/obo/HP_0005574', 'lbl': 'Non-acidotic proximal tubulopathy', 'desc': 'label: Non-acidotic proximal tubulopathy\ndefinition : A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption without bicarbonate loss.\nsynonyms :\n'}


{'id': 'HP_0005575', 'url': 'http://purl.obolibrary.org/obo/HP_0005575', 'lbl': 'Hemolytic-uremic syndrome', 'desc': 'label: Hemolytic-uremic syndrome\ndefinition : A thrombotic microangiopathy with presence of non-immune, intravascular hemolytic anemia, thrombocytopenia and acute kidney injury. A vicious cycle of complement activation, endothelial cell damage, platelet activation, and thrombosis is the hallmark of the disease.\nsynonyms :Hemolytic uremic syndrome\n'}


{'id': 'HP_0005576', 'url': 'http://purl.obolibrary.org/obo/HP_0005576', 'lbl': 'Tubulointerstitial fibrosis', 'desc': 'label: Tubulointerstitial fibrosis\ndefinition : A progressive detrimental connective tissue deposition (fibrosis) on the kidney parenchyma involving the tubules and interstitial tissue of the kidney. Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IF/TA) as the final common pathway. However, IF and TA are separable, as shown by the profound TA in renal artery stenosis, which characteristically has little or no fibrosis (or inflammation). For new annotations it is preferable to annotate to the specific HPO terms for Renal interstitial lfibrosis and/or Renal tubular atrophy.\nsynonyms :Tubulointerstitial renal fibrosis; Tubulointerstitial scarring\n'}


{'id': 'HP_0005579', 'url': 'http://purl.obolibrary.org/obo/HP_0005579', 'lbl': 'Impaired renal ltubular reabsorption of chloride', 'desc': 'label: Impaired renal ltubular reabsorption of chloride\ndefinition : Any impairment of reabsorption of chloride by the kidney in order to not lose too much chloride in the urine.\nsynonyms :Impaired reabsorption of Cl; Impaired reabsorption of Cl-\n'}


{'id': 'HP_0005580', 'url': 'http://purl.obolibrary.org/obo/HP_0005580', 'lbl': 'Duplication of renal pelvis', 'desc': 'label: Duplication of renal pelvis\ndefinition : A duplication of the renal pelvis.\nsynonyms :\n'}


{'id': 'HP_0005583', 'url': 'http://purl.obolibrary.org/obo/HP_0005583', 'lbl': 'Tubular basement membrane disintegration', 'desc': 'label: Tubular basement membrane disintegration\ndefinition : DIsruption and breaking up of the basement membrane of the tubules of the kidney.\nsynonyms :Disintegration of the tubular basement membrane\n'}


{'id': 'HP_0005584', 'url': 'http://purl.obolibrary.org/obo/HP_0005584', 'lbl': 'Renal cell carcinoma', 'desc': 'label: Renal cell carcinoma\ndefinition : A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule.\nsynonyms :Cancer starting in small tubes in kidneys; Hypernephroma; Renal carcinoma\n'}


{'id': 'HP_0005585', 'url': 'http://purl.obolibrary.org/obo/HP_0005585', 'lbl': 'Spotty hyperpigmentation', 'desc': 'label: Spotty hyperpigmentation\ndefinition : \nsynonyms :Patchy hyperpigmentation; Spotty increased pigmentation\n'}


{'id': 'HP_0005586', 'url': 'http://purl.obolibrary.org/obo/HP_0005586', 'lbl': 'Hyperpigmentation in sun-exposed areas', 'desc': 'label: Hyperpigmentation in sun-exposed areas\ndefinition : \nsynonyms :Hyperpigmentation of exposed areas; Increased pigmentation in sun-exposed areas\n'}


{'id': 'HP_0005587', 'url': 'http://purl.obolibrary.org/obo/HP_0005587', 'lbl': 'Profuse pigmented skin lesions', 'desc': 'label: Profuse pigmented skin lesions\ndefinition : \nsynonyms :\n'}