{'id': 'HP_0032378', 'url': 'http://purl.obolibrary.org/obo/HP_0032378', 'lbl': 'Immediate-type hypersensitivity drug reaction', 'desc': 'label: Immediate-type hypersensitivity drug reaction\ndefinition : Hypersensitivity that is observed within 1 hr of exposures. A variety of adverse reactions can occur within minutes to hours of exposure to a drug. Some can be related to the pharmacological action of the drug (WHO Adverse Reaction Terminology type A for augmented) and usually have a low mortality. Others are not readily predictable based on the structure and pharmacological action of the drug and have a relatively high mortality risk (Type B for bizarre). The most serious form of immediate onset drug hypersensitivity reaction, anaphylaxis. Other reactions including itching, dizziness/light-headedness, nausea, chest discomfort but without any objective skin features, physical signs or physiological compromise. Skin only reactions include generalized erythema, urticaria or angioedema without any sentinel features (see below) of other organ involvement.\nsynonyms :\n'}


{'id': 'HP_0032379', 'url': 'http://purl.obolibrary.org/obo/HP_0032379', 'lbl': 'Polymorphous light eruption', 'desc': 'label: Polymorphous light eruption\ndefinition : The cardinal symptom is severely pruritic skin lesions. Macular, papular, papulovesicular, urticarial, multiforme- and plaque-like variants are differentiated morphologically, hence the name polymorphous. Usually one morphology dominates in a single individual (monomorphous). The skin lesions develop a few hours to several days after sun exposure. Initially, patchy erythema develops, accompanied by pruritus. Distinct lesions then develop. The upper chest, upper arms, backs of the hands, thighs, and the sides of the face are the primary localizations. The skin lesions resolve spontaneously within several days of ceasing sun exposure and do not leave behind any traces.\nsynonyms :Sun allergy\n'}


{'id': 'HP_0032381', 'url': 'http://purl.obolibrary.org/obo/HP_0032381', 'lbl': 'Hydroa vacciniforme', 'desc': 'label: Hydroa vacciniforme\ndefinition : In response to the spring sun distinct inflamed reddened skin develops on the ears, nose, cheeks, fingers, backs of the hands, and the lower arms, on which blisters with serous or hemorrhagic content develop. These dry out with the formation of a blackish scab. After shedding of the scab, depressed, varioliform, often hypopigmented scars remain. In addition, hyper- and hypopigmentation are present together, resulting in a polymorphous skin presentation.\nsynonyms :Acute vesiculation and crusting and scarring following sun exposure\n'}


{'id': 'HP_0032382', 'url': 'http://purl.obolibrary.org/obo/HP_0032382', 'lbl': 'Uniparental disomy', 'desc': 'label: Uniparental disomy\ndefinition : Inheritance of both homologues of a chromosome pair from the same parent.\nsynonyms :UPD\n'}


{'id': 'HP_0032383', 'url': 'http://purl.obolibrary.org/obo/HP_0032383', 'lbl': 'Uniparental heterodisomy', 'desc': 'label: Uniparental heterodisomy\ndefinition : A type of uniparental disomy in which the two different chromosomes (or chromosome segments) of the same parent are transmitted.\nsynonyms :\n'}


{'id': 'HP_0032384', 'url': 'http://purl.obolibrary.org/obo/HP_0032384', 'lbl': 'Uniparental isodisomy', 'desc': 'label: Uniparental isodisomy\ndefinition : A type of uniparental disomy in which the two identical chromosomes (or chromosome segments) of the same parent are transmitted.\nsynonyms :\n'}


{'id': 'HP_0032385', 'url': 'http://purl.obolibrary.org/obo/HP_0032385', 'lbl': 'Abnormal circulating transferrin concentration', 'desc': 'label: Abnormal circulating transferrin concentration\ndefinition : Any deviation from the normal concentration of transferrin in the blood circulation.\nsynonyms :Abnormal circulating transferrin level\n'}


{'id': 'HP_0032386', 'url': 'http://purl.obolibrary.org/obo/HP_0032386', 'lbl': 'Elevated circulating transferrin concentration', 'desc': 'label: Elevated circulating transferrin concentration\ndefinition : An abnormally increased concentration of transferrin in the blood circulation.\nsynonyms :Elevated transferrin level\n'}


{'id': 'HP_0032387', 'url': 'http://purl.obolibrary.org/obo/HP_0032387', 'lbl': 'Reduced circulating transferrin concentration', 'desc': 'label: Reduced circulating transferrin concentration\ndefinition : An abnormally decreased concentration of transferrin in the blood circulation.\nsynonyms :Reduced transferrin level\n'}


{'id': 'HP_0032388', 'url': 'http://purl.obolibrary.org/obo/HP_0032388', 'lbl': 'Periventricular nodular heterotopia', 'desc': 'label: Periventricular nodular heterotopia\ndefinition : Nodules of heterotopia along the ventricular walls. There can be a single nodule or a large number of nodules, they can exist on either or both sides of the brain at any point along the higher ventricle margins, they can be small or large, single or multiple.\nsynonyms :\n'}


{'id': 'HP_0032389', 'url': 'http://purl.obolibrary.org/obo/HP_0032389', 'lbl': 'Periventricular laminar heterotopia', 'desc': 'label: Periventricular laminar heterotopia\ndefinition : A large mass of heterotopia in a laminar configuration along the ventricular walls. Usually bilateral.\nsynonyms :\n'}


{'id': 'HP_0032390', 'url': 'http://purl.obolibrary.org/obo/HP_0032390', 'lbl': 'Periventricular ribbonlike heterotopia', 'desc': 'label: Periventricular ribbonlike heterotopia\ndefinition : Heterotopia that forms a continuous wavy line along the ventricular wall.\nsynonyms :\n'}


{'id': 'HP_0032391', 'url': 'http://purl.obolibrary.org/obo/HP_0032391', 'lbl': 'Subcortical heterotopia', 'desc': 'label: Subcortical heterotopia\ndefinition : A form of heterotopia were the mislocalized gray matter is located deep within the white matter.\nsynonyms :\n'}


{'id': 'HP_0032392', 'url': 'http://purl.obolibrary.org/obo/HP_0032392', 'lbl': 'Nodular subcortical heterotopia in peritrigonal regions', 'desc': 'label: Nodular subcortical heterotopia in peritrigonal regions\ndefinition : Solid nodular heterotopia situated in the region of the peritrigonal optic pathway posterior to the deep gray nuclei.\nsynonyms :\n'}


{'id': 'HP_0032393', 'url': 'http://purl.obolibrary.org/obo/HP_0032393', 'lbl': 'Diffuse ribbon-like subcortical heterotopia', 'desc': 'label: Diffuse ribbon-like subcortical heterotopia\ndefinition : Subcortical heterotopia consisting of a bilateral and symmetric single continuous, undulating ribbon-like layer of gray matter located in the frontal, parietal and occipital lobes. It has no visible connection to the overlying cortex.\nsynonyms :\n'}


{'id': 'HP_0032394', 'url': 'http://purl.obolibrary.org/obo/HP_0032394', 'lbl': 'Mesial parasagittal subcortical heterotopia', 'desc': 'label: Mesial parasagittal subcortical heterotopia\ndefinition : Subcortical heterotopia extending along the mesial aspect of the lateral ventricles, with direct connection to mesial polymicrogyria-like cortex at the anterior and posterior limits of the heterotopia.\nsynonyms :\n'}


{'id': 'HP_0032395', 'url': 'http://purl.obolibrary.org/obo/HP_0032395', 'lbl': 'Curvilinear subcortical heterotopia', 'desc': 'label: Curvilinear subcortical heterotopia\ndefinition : Large subcortical heterotopia of variable morphology wiht streaks and swirls. These always connect to the overlying cortex in at least one, but usually in multiple, locations. Spaces with the signal intensity of CSF are usually seen within the heterotopia.\nsynonyms :Giant heterotopia\n'}


{'id': 'HP_0032396', 'url': 'http://purl.obolibrary.org/obo/HP_0032396', 'lbl': 'Transmantle columnar heterotopia', 'desc': 'label: Transmantle columnar heterotopia\ndefinition : Linear heterotopia spanning from the cerebral mantle from the pia to the ependyma.\nsynonyms :\n'}


{'id': 'HP_0032397', 'url': 'http://purl.obolibrary.org/obo/HP_0032397', 'lbl': 'Citrullinuria', 'desc': 'label: Citrullinuria\ndefinition : An increased concentration of citrulline in the urine.\nsynonyms :Citrulline high in urine\n'}


{'id': 'HP_0032398', 'url': 'http://purl.obolibrary.org/obo/HP_0032398', 'lbl': 'Dysgyria', 'desc': 'label: Dysgyria\ndefinition : An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation.\nsynonyms :\n'}


{'id': 'HP_0032399', 'url': 'http://purl.obolibrary.org/obo/HP_0032399', 'lbl': 'Dysgyria with normal cortical thickness', 'desc': 'label: Dysgyria with normal cortical thickness\ndefinition : An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation but with a normal thickness of the cortex.\nsynonyms :\n'}


{'id': 'HP_0032400', 'url': 'http://purl.obolibrary.org/obo/HP_0032400', 'lbl': 'Dysgyria with thickened cortex', 'desc': 'label: Dysgyria with thickened cortex\ndefinition : An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation and a thickened cortex intermediate between pachygyria and polymicrogyria.\nsynonyms :\n'}


{'id': 'HP_0032401', 'url': 'http://purl.obolibrary.org/obo/HP_0032401', 'lbl': 'Aspartic aciduria', 'desc': 'label: Aspartic aciduria\ndefinition : A increased concentration of aspartic acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0032403', 'url': 'http://purl.obolibrary.org/obo/HP_0032403', 'lbl': 'Asparaginuria', 'desc': 'label: Asparaginuria\ndefinition : An increased concentration of asparagine in the urine.\nsynonyms :Increased level of asparagine in urine; Increased urine asparagine level\n'}


{'id': 'HP_0032404', 'url': 'http://purl.obolibrary.org/obo/HP_0032404', 'lbl': 'Testicular mass', 'desc': 'label: Testicular mass\ndefinition : An abnormal bulge or lump in a testis. A testicular mass has a long differential diagnosis including testicular torsion, epididymitis, acute orchitis, strangulated hernia and testicular cancer.\nsynonyms :\n'}


{'id': 'HP_0032405', 'url': 'http://purl.obolibrary.org/obo/HP_0032405', 'lbl': 'Increased urinary phosphoserine level', 'desc': 'label: Increased urinary phosphoserine level\ndefinition : An increased level of phosphoserine in the urine.\nsynonyms :Increased level of phosphoserine in urine\n'}


{'id': 'HP_0032406', 'url': 'http://purl.obolibrary.org/obo/HP_0032406', 'lbl': 'Unilateral perisylvian polymicrogyria', 'desc': 'label: Unilateral perisylvian polymicrogyria\ndefinition : A type of perisylvian polymicrogyria that largely affects one side of the brain.\nsynonyms :\n'}


{'id': 'HP_0032407', 'url': 'http://purl.obolibrary.org/obo/HP_0032407', 'lbl': 'Bilateral perisylvian polymicrogyria', 'desc': 'label: Bilateral perisylvian polymicrogyria\ndefinition : A type of perisylvian polymicrogyria that affects both sides of the brain.\nsynonyms :\n'}


{'id': 'HP_0032408', 'url': 'http://purl.obolibrary.org/obo/HP_0032408', 'lbl': 'Breast mass', 'desc': 'label: Breast mass\ndefinition : A breast lump is any discrete mass in a breast noticed by the patient, significant other, or physician.\nsynonyms :Breast lump\n'}


{'id': 'HP_0032409', 'url': 'http://purl.obolibrary.org/obo/HP_0032409', 'lbl': 'Subcortical band heterotopia', 'desc': 'label: Subcortical band heterotopia\ndefinition : A form of subcortical heterotopia with mislocalized gray matter within the white matter.It is defined as longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter. It is part of the lissencephaly spectrum.\nsynonyms :\n'}


{'id': 'HP_0032410', 'url': 'http://purl.obolibrary.org/obo/HP_0032410', 'lbl': 'Bilateral generalized polymicrogyria', 'desc': 'label: Bilateral generalized polymicrogyria\ndefinition : Symmetric generalized polymicrogyria with no obvious gradient or region of maximal severity; may have abnormal high signal in white matter.\nsynonyms :Bilateral generalised polymicrogyria; Diffuse polymicrogyria\n'}


{'id': 'HP_0032411', 'url': 'http://purl.obolibrary.org/obo/HP_0032411', 'lbl': 'Posterior predominant subcortical band heterotopia', 'desc': 'label: Posterior predominant subcortical band heterotopia\ndefinition : Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the occipital cortex.\nsynonyms :Occipital subcortical band heterotopia; Subcortical band heterotopia posterior predominant\n'}


{'id': 'HP_0032412', 'url': 'http://purl.obolibrary.org/obo/HP_0032412', 'lbl': 'Anterior predominant subcortical band heterotopia', 'desc': 'label: Anterior predominant subcortical band heterotopia\ndefinition : Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible in the frontal and temporal lobes.\nsynonyms :Frontal subcortical band heterotopia; Subcortical band heterotopia anterior predominant\n'}


{'id': 'HP_0032413', 'url': 'http://purl.obolibrary.org/obo/HP_0032413', 'lbl': 'Diffuse subcortical band heterotopia', 'desc': 'label: Diffuse subcortical band heterotopia\ndefinition : Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the whole brain.\nsynonyms :Subcortical band heterotopia diffuse\n'}


{'id': 'HP_0032414', 'url': 'http://purl.obolibrary.org/obo/HP_0032414', 'lbl': 'Hydroxylysinuria', 'desc': 'label: Hydroxylysinuria\ndefinition : The presence of an elevated amount of 5-hydroxylysine in the urine. This compound is a hydroxylated derivative of the amino acid lysine that is present in certain collagens.\nsynonyms :Hydroxylysine high in urine\n'}


{'id': 'HP_0032415', 'url': 'http://purl.obolibrary.org/obo/HP_0032415', 'lbl': 'Parasagittal parieto-occipital polymicrogyria', 'desc': 'label: Parasagittal parieto-occipital polymicrogyria\ndefinition : Polymicrogyria in parasagittal and mesial aspects of parieto-occipital cortex.\nsynonyms :\n'}


{'id': 'HP_0032416', 'url': 'http://purl.obolibrary.org/obo/HP_0032416', 'lbl': 'Retinal microaneurysm', 'desc': 'label: Retinal microaneurysm\ndefinition : A localized dilation of microvasculature formed due to disruption of the internal elastic lamina of a retinal capillary blood vessel. The lesions present as small circular, red dots having distinct margins and are no larger than a blood vessel width at the disk margin. This expansion disturbs the normal flow pattern, changing shear force and pressure along the vessel. Shear force plays a key role in promoting the differentiation and proliferation of endothelial cells.\nsynonyms :\n'}


{'id': 'HP_0032417', 'url': 'http://purl.obolibrary.org/obo/HP_0032417', 'lbl': 'Periglomerular fibrosis', 'desc': "label: Periglomerular fibrosis\ndefinition : Circumferential fibrosis in the interstitium surrounding Bowman's capsule\nsynonyms :Periglomerular fibrotic thickening\n"}


{'id': 'HP_0032418', 'url': 'http://purl.obolibrary.org/obo/HP_0032418', 'lbl': 'Abnormal HDL subfraction concentration', 'desc': 'label: Abnormal HDL subfraction concentration\ndefinition : An abnormal concentration of an HDL subfraction, which can be determined by methods such as electrophoresis followed by densitometric determination of the areas under the peaks. Large HDL subfractions are defined as HDL1 (greater than 12 nm), HDL2b (9.7-12 nm), and HDL2a (8.8-9.69 nm). Small HDL subfractions are defined as HDL3a (8.2-8.79 nm), HDL3b (7.8-8.19 nm), and HDL3c (7.20-7.79 nm).\nsynonyms :\n'}


{'id': 'HP_0032419', 'url': 'http://purl.obolibrary.org/obo/HP_0032419', 'lbl': 'Abnormal HDL2a concentration', 'desc': 'label: Abnormal HDL2a concentration\ndefinition : Any deviation from the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm.\nsynonyms :\n'}


{'id': 'HP_0032420', 'url': 'http://purl.obolibrary.org/obo/HP_0032420', 'lbl': 'Increased HDL2a concentration', 'desc': 'label: Increased HDL2a concentration\ndefinition : An elevation above the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm.\nsynonyms :\n'}


{'id': 'HP_0032421', 'url': 'http://purl.obolibrary.org/obo/HP_0032421', 'lbl': 'Decreased HDL2a concentration', 'desc': 'label: Decreased HDL2a concentration\ndefinition : A reduction below the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2a particle is defined as an HDL particle with a size of 8.80-9.69 nm.\nsynonyms :\n'}


{'id': 'HP_0032422', 'url': 'http://purl.obolibrary.org/obo/HP_0032422', 'lbl': 'Abnormal HDL2b concentration', 'desc': 'label: Abnormal HDL2b concentration\ndefinition : Any deviation from the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm.\nsynonyms :\n'}


{'id': 'HP_0032423', 'url': 'http://purl.obolibrary.org/obo/HP_0032423', 'lbl': 'Decreased HDL2b concentration', 'desc': 'label: Decreased HDL2b concentration\ndefinition : A reduction below the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm.\nsynonyms :\n'}


{'id': 'HP_0032424', 'url': 'http://purl.obolibrary.org/obo/HP_0032424', 'lbl': 'Increased HDL2b concentration', 'desc': 'label: Increased HDL2b concentration\ndefinition : An elevation above the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm.\nsynonyms :\n'}


{'id': 'HP_0032425', 'url': 'http://purl.obolibrary.org/obo/HP_0032425', 'lbl': 'Abnormal HDL3a concentration', 'desc': 'label: Abnormal HDL3a concentration\ndefinition : Any deviation from the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.\nsynonyms :\n'}


{'id': 'HP_0032426', 'url': 'http://purl.obolibrary.org/obo/HP_0032426', 'lbl': 'Abnormal HDL3b concentration', 'desc': 'label: Abnormal HDL3b concentration\ndefinition : Any deviation from the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.\nsynonyms :\n'}


{'id': 'HP_0032427', 'url': 'http://purl.obolibrary.org/obo/HP_0032427', 'lbl': 'Abnormal HDL3c concentration', 'desc': 'label: Abnormal HDL3c concentration\ndefinition : Any deviation from the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.\nsynonyms :\n'}


{'id': 'HP_0032428', 'url': 'http://purl.obolibrary.org/obo/HP_0032428', 'lbl': 'Increased HDL3a concentration', 'desc': 'label: Increased HDL3a concentration\ndefinition : An elevation above the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.\nsynonyms :\n'}


{'id': 'HP_0032429', 'url': 'http://purl.obolibrary.org/obo/HP_0032429', 'lbl': 'Decreased HDL3a concentration', 'desc': 'label: Decreased HDL3a concentration\ndefinition : A reduction below the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.\nsynonyms :\n'}


{'id': 'HP_0032430', 'url': 'http://purl.obolibrary.org/obo/HP_0032430', 'lbl': 'Increased HDL3b concentration', 'desc': 'label: Increased HDL3b concentration\ndefinition : An elevation above the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.\nsynonyms :\n'}


{'id': 'HP_0032431', 'url': 'http://purl.obolibrary.org/obo/HP_0032431', 'lbl': 'Decreased HDL3b concentration', 'desc': 'label: Decreased HDL3b concentration\ndefinition : A reduction below the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.\nsynonyms :\n'}


{'id': 'HP_0032432', 'url': 'http://purl.obolibrary.org/obo/HP_0032432', 'lbl': 'Increased HDL3c concentration', 'desc': 'label: Increased HDL3c concentration\ndefinition : An elevation above the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.\nsynonyms :\n'}


{'id': 'HP_0032433', 'url': 'http://purl.obolibrary.org/obo/HP_0032433', 'lbl': 'Decreased HDL3c concentration', 'desc': 'label: Decreased HDL3c concentration\ndefinition : A reduction below the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.\nsynonyms :\n'}


{'id': 'HP_0032434', 'url': 'http://purl.obolibrary.org/obo/HP_0032434', 'lbl': 'Delayed umbilical cord separation', 'desc': 'label: Delayed umbilical cord separation\ndefinition : Separation of the umbilical cord occurs at an abnormally late timepoint.\nsynonyms :Delayed separation of umbilical cord\n'}


{'id': 'HP_0032435', 'url': 'http://purl.obolibrary.org/obo/HP_0032435', 'lbl': 'Neonatal omphalitis', 'desc': 'label: Neonatal omphalitis\ndefinition : An infection of the umbilicus and/or surrounding tissues occurring in the neonatal period.\nsynonyms :Omphalitis; Umbilical cord stump infection\n'}


{'id': 'HP_0032436', 'url': 'http://purl.obolibrary.org/obo/HP_0032436', 'lbl': 'Abnormal circulating C-reactive protein concentration', 'desc': 'label: Abnormal circulating C-reactive protein concentration\ndefinition : Any deviation from the normal concentration of C-reactive protein in the blood circulation.\nsynonyms :Abnormal C-reactive protein level\n'}


{'id': 'HP_0032437', 'url': 'http://purl.obolibrary.org/obo/HP_0032437', 'lbl': 'Reduced circulating C-reactive protein concecntration', 'desc': 'label: Reduced circulating C-reactive protein concecntration\ndefinition : An abnormal decrease of the C-reactive protein level in serum.\nsynonyms :Reduced C-reactive protein level\n'}


{'id': 'HP_0032438', 'url': 'http://purl.obolibrary.org/obo/HP_0032438', 'lbl': 'Platelet anisocytosis', 'desc': 'label: Platelet anisocytosis\ndefinition : Abnormally increased variability in the size of platelets.\nsynonyms :\n'}


{'id': 'HP_0032439', 'url': 'http://purl.obolibrary.org/obo/HP_0032439', 'lbl': 'Airborn particle hypersensitivity', 'desc': 'label: Airborn particle hypersensitivity\ndefinition : An abnormally increased sensitivity to airborn particles. This can be diagnosed on the basis of the medical history, taking into account seasonality or a relationship to the concentration of airborn particles in the environment of the affected individual. Aerosol challenge is a gold standard of establishment of the symptom. There exist particle hypersensitivity (diesel exhaust, metals, inorganic material) vs. allergen (including pollen dander, etc) hypersensitivity. The responses are usually different and testing for allergen hypersensitivity is done in concert with serum IgE and or skin testing to the suspected allergen.\nsynonyms :\n'}


{'id': 'HP_0032440', 'url': 'http://purl.obolibrary.org/obo/HP_0032440', 'lbl': 'Blood group B', 'desc': 'label: Blood group B\ndefinition : ABO phenotype B, corresponding to the genotype BO or BB.\nsynonyms :\n'}


{'id': 'HP_0032441', 'url': 'http://purl.obolibrary.org/obo/HP_0032441', 'lbl': 'Blood group AB', 'desc': 'label: Blood group AB\ndefinition : ABO phenotype AB, corresponding to the genotype AB.\nsynonyms :\n'}


{'id': 'HP_0032442', 'url': 'http://purl.obolibrary.org/obo/HP_0032442', 'lbl': 'Blood group O', 'desc': 'label: Blood group O\ndefinition : ABO phenotype O, corresponding to the genotype OO.\nsynonyms :\n'}


{'id': 'HP_0032443', 'url': 'http://purl.obolibrary.org/obo/HP_0032443', 'lbl': 'Past medical history', 'desc': "label: Past medical history\ndefinition : In a medical encounter, the physician generally will interview the patient about his or her current problem, and may perform additional testing. The past medical history (PMH) in contrast records information about the patient's medical, personal and family history that might be relevant to the presenting illness or to provide optimal clinical management. The PMH generally includes (if relevant) other major illnesses, hospitalizations, surgeries, injuries, allergies, gynecologic and obstetric history, family history, personal history including occupational history, alcohol and drug use, etc.\nsynonyms :\n"}


{'id': 'HP_0032444', 'url': 'http://purl.obolibrary.org/obo/HP_0032444', 'lbl': 'Status post organ transplantation', 'desc': 'label: Status post organ transplantation\ndefinition : The affected individual has received an organ transplant previous to the current medical encounter.\nsynonyms :s/p organ transplantation\n'}


{'id': 'HP_0032445', 'url': 'http://purl.obolibrary.org/obo/HP_0032445', 'lbl': 'Pulmonary cyst', 'desc': 'label: Pulmonary cyst\ndefinition : A round circumscribed space within a lung that is surrounded by an epithelial or fibrous wall of variable thickness. A cyst usually has a thin and regular wall (less than 2 mm) and contains air, although some may contain fluid.\nsynonyms :Lung cyst\n'}


{'id': 'HP_0032446', 'url': 'http://purl.obolibrary.org/obo/HP_0032446', 'lbl': 'Pulmonary bulla', 'desc': 'label: Pulmonary bulla\ndefinition : Pulmonary bullae are rounded focal regions of emphysema with a thin wall which measure more than 1 cm in diameter. They are often subpleural in location and are typically larger in the apices. In some cases, bullae can be very large and result in compression of adjacent lung tissue. A giant bulla is arbitrarily defined as one that occupies at least one third of the volume of a hemithorax. When large, bullae can simulate pneumothorax. The most common cause is paraseptal emphysema but bullae may also be seen in association with centrilobular emphysema.\nsynonyms :Pulmonary bullae\n'}


{'id': 'HP_0032447', 'url': 'http://purl.obolibrary.org/obo/HP_0032447', 'lbl': 'Pulmonary bleb', 'desc': 'label: Pulmonary bleb\ndefinition : A bleb is a small gas-containing space within the visceral pleura or in the subpleural lung, not larger than 1 cm in diameter. CT findings show a bleb as a thin-walled cystic air space contiguous with the pleura.\nsynonyms :\n'}


{'id': 'HP_0032448', 'url': 'http://purl.obolibrary.org/obo/HP_0032448', 'lbl': 'Achlorhydria', 'desc': 'label: Achlorhydria\ndefinition : A condition in which production of hydrochloric acid in the stomach is absent.\nsynonyms :\n'}


{'id': 'HP_0032449', 'url': 'http://purl.obolibrary.org/obo/HP_0032449', 'lbl': 'Abnormal dermoepidermal hemidesmosome morphology', 'desc': 'label: Abnormal dermoepidermal hemidesmosome morphology\ndefinition : An abnormal structure or appearance of hemidesmosomes, multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane.\nsynonyms :\n'}


{'id': 'HP_0032450', 'url': 'http://purl.obolibrary.org/obo/HP_0032450', 'lbl': 'Positive blood arsenic test', 'desc': 'label: Positive blood arsenic test\ndefinition : Detection of arsenic in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032451', 'url': 'http://purl.obolibrary.org/obo/HP_0032451', 'lbl': 'Oral melanotic macule', 'desc': 'label: Oral melanotic macule\ndefinition : Flat, distinct, discolored area of oral mucosal membrane less than 1 cm wide not associated with a change in the thickness or texture of the affected mucosal membrane. The lesions are small, solitary, well-circumscribed and often uniformly pigmented.\nsynonyms :Melanotic macule of oral mucosa\n'}


{'id': 'HP_0032452', 'url': 'http://purl.obolibrary.org/obo/HP_0032452', 'lbl': 'Oral melanoacanthoma', 'desc': 'label: Oral melanoacanthoma\ndefinition : Oral melanoacanthoma usually presents as an asymptomatic, ill-defined, rapidly enlarging, macular pigmentation. Although most lesions are heavily pigmented, the coloration may or may not be uniform. Any mucosal site may be affected, but buccal mucosal involvement is most common. Although typically solitary, rare patients may present with multifocal lesions.\nsynonyms :\n'}


{'id': 'HP_0032453', 'url': 'http://purl.obolibrary.org/obo/HP_0032453', 'lbl': 'Abnormal lip pigmentation', 'desc': 'label: Abnormal lip pigmentation\ndefinition : Abnormal coloring of the lip, whereby the lip discolored, blotchy, or darker or lighter than normal.\nsynonyms :\n'}


{'id': 'HP_0032454', 'url': 'http://purl.obolibrary.org/obo/HP_0032454', 'lbl': 'Labial melanotic macule', 'desc': 'label: Labial melanotic macule\ndefinition : Flat, distinct, discolored area on the lip less than 1 cm wide not associated with a change in the thickness or texture.\nsynonyms :Labial melanotic freckle\n'}


{'id': 'HP_0032455', 'url': 'http://purl.obolibrary.org/obo/HP_0032455', 'lbl': 'Reduced granulocyte CD18 level', 'desc': 'label: Reduced granulocyte CD18 level\ndefinition : Reduced level of CD18 on the granulocyte surface. This feature can be assessed by flow cytometry.\nsynonyms :\n'}


{'id': 'HP_0032456', 'url': 'http://purl.obolibrary.org/obo/HP_0032456', 'lbl': 'Unlayered lissencephaly', 'desc': 'label: Unlayered lissencephaly\ndefinition : A type of lissencephaly whereby upon neuropathological examination the cortical plate is severely disorganized with a festooned-like pattern and with neither lamination nor clear demarcation between white and grey matter.\nsynonyms :\n'}


{'id': 'HP_0032457', 'url': 'http://purl.obolibrary.org/obo/HP_0032457', 'lbl': '2-3-layered lissencephaly', 'desc': 'label: 2-3-layered lissencephaly\ndefinition : Pachygyria-agyria spectrum whereby at neuropathological examination the cortical plate consists of a two-three layered organization made up of a molecular layer, a relatively thin wavy layer with a higher cellular density and a third layer with lower cellularity.\nsynonyms :\n'}


{'id': 'HP_0032458', 'url': 'http://purl.obolibrary.org/obo/HP_0032458', 'lbl': 'Narrowing of medullary canal', 'desc': 'label: Narrowing of medullary canal\ndefinition : A reduction in diameter and volume of the central cavity of bone where red or yellow bone marrow is located.\nsynonyms :Medullary cavity obliteration; Narrowing of bone marrow canal; Narrowing of bone medullary canal; Narrowing of the marrow cavity\n'}


{'id': 'HP_0032459', 'url': 'http://purl.obolibrary.org/obo/HP_0032459', 'lbl': 'Abnormal phosphoribosylpyrophosphate synthetase level', 'desc': 'label: Abnormal phosphoribosylpyrophosphate synthetase level\ndefinition : Any deviation from the normal level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate.\nsynonyms :\n'}


{'id': 'HP_0032460', 'url': 'http://purl.obolibrary.org/obo/HP_0032460', 'lbl': 'Decreased phosphoribosylpyrophosphate synthetase level', 'desc': 'label: Decreased phosphoribosylpyrophosphate synthetase level\ndefinition : Abnormally reduced level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate.\nsynonyms :\n'}


{'id': 'HP_0032461', 'url': 'http://purl.obolibrary.org/obo/HP_0032461', 'lbl': 'obsolete Tiger-tail banding', 'desc': 'label: obsolete Tiger-tail banding\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032462', 'url': 'http://purl.obolibrary.org/obo/HP_0032462', 'lbl': 'Increased circulating palmitate level', 'desc': 'label: Increased circulating palmitate level\ndefinition : An elevation beyond the normal concentration of palmitate (palmitic acid) in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032463', 'url': 'http://purl.obolibrary.org/obo/HP_0032463', 'lbl': 'Reduced circulating fibronectin level', 'desc': 'label: Reduced circulating fibronectin level\ndefinition : A reduction below the normal concentration of fibronectin the the blood circulation.\nsynonyms :Decreased plasma fibronectin\n'}


{'id': 'HP_0032464', 'url': 'http://purl.obolibrary.org/obo/HP_0032464', 'lbl': 'Ureteral hypoplasia', 'desc': 'label: Ureteral hypoplasia\ndefinition : Underdevelopment of the ureter.\nsynonyms :Hypoplasia of the ureter; Ureter hypoplasia\n'}


{'id': 'HP_0032465', 'url': 'http://purl.obolibrary.org/obo/HP_0032465', 'lbl': 'Bladder trabeculation', 'desc': 'label: Bladder trabeculation\ndefinition : Muscular projections that protrude into the lumen of the bladder, criss-crossing the walls of the bladder on its inner surface.\nsynonyms :Trabecular bladder\n'}


{'id': 'HP_0032466', 'url': 'http://purl.obolibrary.org/obo/HP_0032466', 'lbl': 'Aplasia of the olfactory bulb', 'desc': 'label: Aplasia of the olfactory bulb\ndefinition : Lack of formation (congenital absence) of the olfactory bulb.\nsynonyms :Aplastic olfactory bulb; Olfactory bulb aplasia\n'}


{'id': 'HP_0032467', 'url': 'http://purl.obolibrary.org/obo/HP_0032467', 'lbl': 'Past obstetric history', 'desc': 'label: Past obstetric history\ndefinition : Information about past pregnancies including gravidity (number of times a woman has been pregnant, regardless of the outcome), parity (total number of births), gestational age of births, and medical conditions related to past pregnancies.\nsynonyms :Maternal medical history\n'}


{'id': 'HP_0032468', 'url': 'http://purl.obolibrary.org/obo/HP_0032468', 'lbl': 'History of stillbirth', 'desc': 'label: History of stillbirth\ndefinition : One or more previous pregnancies resulted in stillbirth, defined as death of a fetus in the later stages of pregnancy (definitions in the literature vary, with cut-offs ranging from 20 to 28 weeks gestation).\nsynonyms :\n'}


{'id': 'HP_0032469', 'url': 'http://purl.obolibrary.org/obo/HP_0032469', 'lbl': 'Anti-asialoglycoprotein receptor antibody positivity', 'desc': 'label: Anti-asialoglycoprotein receptor antibody positivity\ndefinition : Presence of autoantibodies against the asialoglycoprotein receptor (ASGPR) in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032470', 'url': 'http://purl.obolibrary.org/obo/HP_0032470', 'lbl': 'Monilethrix', 'desc': 'label: Monilethrix\ndefinition : The hair shaft has a beaded appearance due to the presence of elliptical nodes that have the diameter of normal hair and are medullated, regularly separated by internodes that are narrow, devoid of medulla and are the site of fracture.\nsynonyms :\n'}


{'id': 'HP_0032471', 'url': 'http://purl.obolibrary.org/obo/HP_0032471', 'lbl': 'Focal polymicrogyria', 'desc': 'label: Focal polymicrogyria\ndefinition : Polymicrogyria affecting one or multiple small areas of the cerebral cortex.\nsynonyms :\n'}


{'id': 'HP_0032472', 'url': 'http://purl.obolibrary.org/obo/HP_0032472', 'lbl': 'Abnormal urine urobilinogen level', 'desc': 'label: Abnormal urine urobilinogen level\ndefinition : An abnormal concentration of urobilinogen in the urine.\nsynonyms :\n'}


{'id': 'HP_0032473', 'url': 'http://purl.obolibrary.org/obo/HP_0032473', 'lbl': 'Decreased urine urobilinogen', 'desc': 'label: Decreased urine urobilinogen\ndefinition : An abnormally reduced concentration of urobilinogen in the urine.\nsynonyms :\n'}


{'id': 'HP_0032475', 'url': 'http://purl.obolibrary.org/obo/HP_0032475', 'lbl': '6-layered lissencephaly', 'desc': 'label: 6-layered lissencephaly\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032476', 'url': 'http://purl.obolibrary.org/obo/HP_0032476', 'lbl': 'Abnormal circulating vitamin B6 level', 'desc': 'label: Abnormal circulating vitamin B6 level\ndefinition : An abnormal concentration of vitamin B6 in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032477', 'url': 'http://purl.obolibrary.org/obo/HP_0032477', 'lbl': 'Elevated circulating vitamin B6 level', 'desc': 'label: Elevated circulating vitamin B6 level\ndefinition : An abnormally increased concentration of vitamin B6 in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032478', 'url': 'http://purl.obolibrary.org/obo/HP_0032478', 'lbl': 'Lateral spinal meningocele', 'desc': 'label: Lateral spinal meningocele\ndefinition : Protrusion of the arachnoid and dura through spinal foramina.\nsynonyms :\n'}


{'id': 'HP_0032479', 'url': 'http://purl.obolibrary.org/obo/HP_0032479', 'lbl': 'Preimplantation lethality', 'desc': "label: Preimplantation lethality\ndefinition : It is estimated that about 40-70 percent of human embryos produced in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are viable embryos, whereas others arrest at different early stages of development. The phenotype of preimplantation lethality is inferred if IVF and ICSI cycles fail because all of an individual's embryos are arrested at early stages of development.\nsynonyms :Preimplantation embryonic lethality\n"}


{'id': 'HP_0032480', 'url': 'http://purl.obolibrary.org/obo/HP_0032480', 'lbl': 'Beta-aminoisobutyric aciduria', 'desc': 'label: Beta-aminoisobutyric aciduria\ndefinition : An increased amount of beta-aminoisobutyric acid in the urine. Beta-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.\nsynonyms :\n'}


{'id': 'HP_0032481', 'url': 'http://purl.obolibrary.org/obo/HP_0032481', 'lbl': 'Abnormal pituitary glycoprotein hormone alpha subunit level', 'desc': 'label: Abnormal pituitary glycoprotein hormone alpha subunit level\ndefinition : Any deviation from the normal concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081).\nsynonyms :\n'}


{'id': 'HP_0032482', 'url': 'http://purl.obolibrary.org/obo/HP_0032482', 'lbl': 'Decreased pituitary glycoprotein hormone alpha subunit level', 'desc': 'label: Decreased pituitary glycoprotein hormone alpha subunit level\ndefinition : An reduced concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081).\nsynonyms :Decreased pituitary glycoprotein alpha subunit level; Decreased pituitary glycoprotein polypeptide alpha subunit level\n'}


{'id': 'HP_0032483', 'url': 'http://purl.obolibrary.org/obo/HP_0032483', 'lbl': 'obsolete Abnormal fecal test result', 'desc': 'label: obsolete Abnormal fecal test result\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032484', 'url': 'http://purl.obolibrary.org/obo/HP_0032484', 'lbl': 'Elevated fecal sodium', 'desc': 'label: Elevated fecal sodium\ndefinition : An elevated concentration of sodium in feces.\nsynonyms :Elevated faecal sodium\n'}


{'id': 'HP_0032485', 'url': 'http://purl.obolibrary.org/obo/HP_0032485', 'lbl': 'Abnormal fecal osmolality', 'desc': 'label: Abnormal fecal osmolality\ndefinition : Abnormal concentration of feces as assessed by the total number of solute particles per kilogram.\nsynonyms :Abnormal faecal osmolality\n'}


{'id': 'HP_0032486', 'url': 'http://purl.obolibrary.org/obo/HP_0032486', 'lbl': 'Elevated fecal osmolality', 'desc': 'label: Elevated fecal osmolality\ndefinition : Abnormally high concentration of feces as assessed by the total number of solute particles per kilogram.\nsynonyms :Elevated faecal osmolality\n'}


{'id': 'HP_0032487', 'url': 'http://purl.obolibrary.org/obo/HP_0032487', 'lbl': 'Reduced fecal osmolality', 'desc': 'label: Reduced fecal osmolality\ndefinition : Abnormally low concentration of feces as assessed by the total number of solute particles per kilogram.\nsynonyms :Reduced faecal osmolality\n'}


{'id': 'HP_0032488', 'url': 'http://purl.obolibrary.org/obo/HP_0032488', 'lbl': 'Abnormal fecal pH', 'desc': 'label: Abnormal fecal pH\ndefinition : Any deviation from the normal pH of feces. The pH reflects the acidity or alkalinity of a solution on a logarithmic scale on which 7 is neutral, whereby lower values are more acid and higher values more alkaline.\nsynonyms :Abnormal faecal pH\n'}


{'id': 'HP_0032489', 'url': 'http://purl.obolibrary.org/obo/HP_0032489', 'lbl': 'Elevated fecal pH', 'desc': 'label: Elevated fecal pH\ndefinition : Abnormally high fecal pH, i.e., abnormal alkalinity of feces.\nsynonyms :Elevated faecal pH; Stool pH high\n'}


{'id': 'HP_0032490', 'url': 'http://purl.obolibrary.org/obo/HP_0032490', 'lbl': 'Decreased fecal pH', 'desc': 'label: Decreased fecal pH\ndefinition : Abnormally low fecal pH, i.e., abnormal acidity of feces.\nsynonyms :Decreased faecal pH; Stool pH low\n'}


{'id': 'HP_0032491', 'url': 'http://purl.obolibrary.org/obo/HP_0032491', 'lbl': 'Increased circulating argininosuccinic acid', 'desc': 'label: Increased circulating argininosuccinic acid\ndefinition : An increased level of the non-proteinogenic amino acid argininosuccinic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032492', 'url': 'http://purl.obolibrary.org/obo/HP_0032492', 'lbl': 'Anti-myelin oligodendrocyte glycoprotein antibody positivity', 'desc': 'label: Anti-myelin oligodendrocyte glycoprotein antibody positivity\ndefinition : Presence of antibodies in the serum that react against myelin oligodendrocyte glycoprotein.\nsynonyms :Anti-MOG antibody positivity\n'}


{'id': 'HP_0032493', 'url': 'http://purl.obolibrary.org/obo/HP_0032493', 'lbl': 'Increased circulating trypsinogen', 'desc': 'label: Increased circulating trypsinogen\ndefinition : An abnormally high concentration of trypsinogen in the blood circulation.\nsynonyms :Increased immunoreactive trypsinogen\n'}


{'id': 'HP_0032495', 'url': 'http://purl.obolibrary.org/obo/HP_0032495', 'lbl': 'Abnormal terminal:vellus ratio', 'desc': 'label: Abnormal terminal:vellus ratio\ndefinition : A deviation from the normal proportion of terminal to vellus hairs.\nsynonyms :\n'}


{'id': 'HP_0032496', 'url': 'http://purl.obolibrary.org/obo/HP_0032496', 'lbl': 'Elevated terminal:vellus ratio', 'desc': 'label: Elevated terminal:vellus ratio\ndefinition : An increased proportion of terminal hairs compared to vellus hairs.\nsynonyms :\n'}


{'id': 'HP_0032497', 'url': 'http://purl.obolibrary.org/obo/HP_0032497', 'lbl': 'Reduced terminal:vellus ratio', 'desc': 'label: Reduced terminal:vellus ratio\ndefinition : A terminal:vellus ratio under 4:1 is characteristic of androgenetic alopecia.\nsynonyms :\n'}


{'id': 'HP_0032499', 'url': 'http://purl.obolibrary.org/obo/HP_0032499', 'lbl': 'Giant neutrophil granules', 'desc': 'label: Giant neutrophil granules\ndefinition : The presence of abnormally large granules in neutrophils. This finding can be appreciated on a peripheral blood smear. The finding is characteristic of Chediak Higashi syndrome. The giant granules are derived from azurophil granules, whereas peroxidase-negative granules are not involved in their formation.\nsynonyms :\n'}


{'id': 'HP_0032500', 'url': 'http://purl.obolibrary.org/obo/HP_0032500', 'lbl': 'Exacerbated by tobacco use', 'desc': 'label: Exacerbated by tobacco use\ndefinition : Applied to a sign or symptom that is worsened by smoking tobacco products.\nsynonyms :Aggravated by tobacco use; Exacerbated by smoking; Smoking or tobacco use exacerbates symptoms\n'}


{'id': 'HP_0032501', 'url': 'http://purl.obolibrary.org/obo/HP_0032501', 'lbl': 'Exacerbated by contraceptive medication', 'desc': 'label: Exacerbated by contraceptive medication\ndefinition : Applied to a sign or symptom that is worsened by taking contraceptive medication.\nsynonyms :Contraceptive pills aggravate symptoms\n'}


{'id': 'HP_0032502', 'url': 'http://purl.obolibrary.org/obo/HP_0032502', 'lbl': 'Exacerbated by barbiturate medication', 'desc': 'label: Exacerbated by barbiturate medication\ndefinition : Applied to a sign or symptom that is worsened by taking barbituates.\nsynonyms :Barbiturates produce worsening\n'}


{'id': 'HP_0032503', 'url': 'http://purl.obolibrary.org/obo/HP_0032503', 'lbl': 'Ameliorated by ethanol ingestion', 'desc': 'label: Ameliorated by ethanol ingestion\ndefinition : Applies to a sign or symptom that is improved or made more bearable by drinking alcohol (ethanol).\nsynonyms :Ethanol reduces manifestations\n'}


{'id': 'HP_0032504', 'url': 'http://purl.obolibrary.org/obo/HP_0032504', 'lbl': "Lhermitte's sign", 'desc': "label: Lhermitte's sign\ndefinition : An electric shock-like sensation that occurs on flexion of the neck. This sensation radiates down the spine, often into the legs, arms, and sometimes to the trunk.\nsynonyms :Barber chair phenomenon; Lhermitte's phenomenon\n"}


{'id': 'HP_0032505', 'url': 'http://purl.obolibrary.org/obo/HP_0032505', 'lbl': 'Hydrophobia', 'desc': 'label: Hydrophobia\ndefinition : Pharyngeal spasms provoked by an attempt to drink.\nsynonyms :\n'}


{'id': 'HP_0032506', 'url': 'http://purl.obolibrary.org/obo/HP_0032506', 'lbl': 'Alien limb phenomenon', 'desc': 'label: Alien limb phenomenon\ndefinition : Alien limb phenomenon refers to involuntary motor activity of a limb in conjunction with the feeling of estrangement from that limb.\nsynonyms :\n'}


{'id': 'HP_0032507', 'url': 'http://purl.obolibrary.org/obo/HP_0032507', 'lbl': 'Labiomental fasciculations', 'desc': 'label: Labiomental fasciculations\ndefinition : Fasciculations affecting the tongue muscle and the musculature of the chin.\nsynonyms :Fasciculations, labiomental\n'}


{'id': 'HP_0032508', 'url': 'http://purl.obolibrary.org/obo/HP_0032508', 'lbl': 'Polyembolokoilamania', 'desc': 'label: Polyembolokoilamania\ndefinition : Habitual insertion of foreign bodies into bodily orifices.\nsynonyms :\n'}


{'id': 'HP_0032509', 'url': 'http://purl.obolibrary.org/obo/HP_0032509', 'lbl': 'Onychotillomania', 'desc': 'label: Onychotillomania\ndefinition : Onychotillomania is characterized by the compulsive or irresistible urge in patients to pick at, pull off, or harmfully bite or chew their nails.\nsynonyms :\n'}


{'id': 'HP_0032510', 'url': 'http://purl.obolibrary.org/obo/HP_0032510', 'lbl': 'Tendon pain', 'desc': 'label: Tendon pain\ndefinition : An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to a tendon.\nsynonyms :\n'}


{'id': 'HP_0032511', 'url': 'http://purl.obolibrary.org/obo/HP_0032511', 'lbl': 'Superiorly positioned umbilicus', 'desc': 'label: Superiorly positioned umbilicus\ndefinition : The position of the umbilicus (belly button) is abnormally high (superior).\nsynonyms :\n'}


{'id': 'HP_0032513', 'url': 'http://purl.obolibrary.org/obo/HP_0032513', 'lbl': 'Four-vessel umbilical cord', 'desc': 'label: Four-vessel umbilical cord\ndefinition : Four-vessel umbilical cord containing two arteries and two veins.\nsynonyms :\n'}


{'id': 'HP_0032514', 'url': 'http://purl.obolibrary.org/obo/HP_0032514', 'lbl': 'Duplicated lacrimal punctum', 'desc': 'label: Duplicated lacrimal punctum\ndefinition : A congenital developmental anomaly characterized by the presence of two (instead of the normal one) lacrimal punctum on one or both sides of the face.\nsynonyms :Double lacrimal puncta; Lacrimal punctum, duplication\n'}


{'id': 'HP_0032515', 'url': 'http://purl.obolibrary.org/obo/HP_0032515', 'lbl': 'Deep dermatophytosis', 'desc': 'label: Deep dermatophytosis\ndefinition : A type of invasive dermatophyte infection of the deep dermis characterized by extensive dermal infiltration by fungal elements.\nsynonyms :\n'}


{'id': 'HP_0032516', 'url': 'http://purl.obolibrary.org/obo/HP_0032516', 'lbl': 'Invasive dermatophyte infection', 'desc': 'label: Invasive dermatophyte infection\ndefinition : Infection that extends deeply into the dermis by dermatophytes, fungi that typically cause different types of superficial infection (tinea) or skin, hair, or nails.\nsynonyms :\n'}


{'id': 'HP_0032517', 'url': 'http://purl.obolibrary.org/obo/HP_0032517', 'lbl': "Majocchi's granuloma", 'desc': "label: Majocchi's granuloma\ndefinition : Majocchi's granuloma (MG) is an inflammatory and granulomatous, dermatophytic infection characterized by a granulomatous inflammation around the hair follicle. Histopathologically, MG demonstrates a nodular perifollicular granulomatous infiltrate of lymphoid cells, macrophages, epithelioid cells, multinucleated giant cells, and neutrophils. Unlike superficial dermatophytoses, fungal hyphae and spores can be detected not only on the surface of the epidermis but also within or around the hair follicles.\nsynonyms :\n"}


{'id': 'HP_0032518', 'url': 'http://purl.obolibrary.org/obo/HP_0032518', 'lbl': 'Disseminated dermatophytosis', 'desc': 'label: Disseminated dermatophytosis\ndefinition : A type of invasive dermatophyte infection characterized by vascular involvement and dissemination to other organs.\nsynonyms :\n'}


{'id': 'HP_0032519', 'url': 'http://purl.obolibrary.org/obo/HP_0032519', 'lbl': 'Increased Burr cell count', 'desc': 'label: Increased Burr cell count\ndefinition : Burr cells, also known as echinocytes, have a speculated border over the entire cell surface. Burr cells are commonly found in both end-stage renal disease and liver disease. Small numbers of Burr cells are commonly found in healthy individuals.\nsynonyms :\n'}


{'id': 'HP_0032520', 'url': 'http://purl.obolibrary.org/obo/HP_0032520', 'lbl': 'Masseter muscular weakness', 'desc': 'label: Masseter muscular weakness\ndefinition : Reduced strength of the masseter muscle, whose primary function is to elevate the mandible and thereby raise the mandible towards the maxilla, closing the jaw.\nsynonyms :\n'}


{'id': 'HP_0032521', 'url': 'http://purl.obolibrary.org/obo/HP_0032521', 'lbl': 'Self hugging', 'desc': 'label: Self hugging\ndefinition : Involuntary, tic-like movements consisted of crossing both arms across the chest and tensing the body or clasping the hands and squeezing the arms to the sides. The movements last a few seconds and may occur in series or flurries, generally accompanied by facial grimacing and occasional grunting.\nsynonyms :Spasmodic upper-body squeeze\n'}


{'id': 'HP_0032522', 'url': 'http://purl.obolibrary.org/obo/HP_0032522', 'lbl': 'Ameliorated by immunosuppresion', 'desc': 'label: Ameliorated by immunosuppresion\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with immunosuppresive medication.\nsynonyms :Immunosupressive therapy improves condition\n'}


{'id': 'HP_0032523', 'url': 'http://purl.obolibrary.org/obo/HP_0032523', 'lbl': 'Tendon thickening', 'desc': 'label: Tendon thickening\ndefinition : An abnormal increase in the thickness (diameter) of a tendon.\nsynonyms :\n'}


{'id': 'HP_0032524', 'url': 'http://purl.obolibrary.org/obo/HP_0032524', 'lbl': 'Long thumb', 'desc': 'label: Long thumb\ndefinition : Length of the thumb is greater than normal.\nsynonyms :\n'}


{'id': 'HP_0032525', 'url': 'http://purl.obolibrary.org/obo/HP_0032525', 'lbl': 'Aggravated by acetylcholinesterase inhibitor', 'desc': 'label: Aggravated by acetylcholinesterase inhibitor\ndefinition : Applied to a sign or symptom that is worsened by treatment with an acetylcholinesterase inhibitor such as tensilon (edrophonium) or pyridostigmine (Mestinon).\nsynonyms :\n'}


{'id': 'HP_0032526', 'url': 'http://purl.obolibrary.org/obo/HP_0032526', 'lbl': 'Ameliorated by acetylcholinesterase inhibitor', 'desc': 'label: Ameliorated by acetylcholinesterase inhibitor\ndefinition : Applies to a sign or symptom that is improved or made more bearable by an acetylcholinesterase inhibitor such as mestinon or tensilon.\nsynonyms :\n'}


{'id': 'HP_0032527', 'url': 'http://purl.obolibrary.org/obo/HP_0032527', 'lbl': 'Inferiorly positioned umbilicus', 'desc': 'label: Inferiorly positioned umbilicus\ndefinition : The position of the umbilicus (belly button) is abnormally low (inferior).\nsynonyms :Low set umbilicus; Low-set umbilicus\n'}


{'id': 'HP_0032528', 'url': 'http://purl.obolibrary.org/obo/HP_0032528', 'lbl': 'Elevated urinary 4-hydroxybutyric acid', 'desc': 'label: Elevated urinary 4-hydroxybutyric acid\ndefinition : An increased amount of 4-hydroxybutyric acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0032529', 'url': 'http://purl.obolibrary.org/obo/HP_0032529', 'lbl': 'obsolete Elevated circulating gamma-aminobutyric acid concentration', 'desc': 'label: obsolete Elevated circulating gamma-aminobutyric acid concentration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032530', 'url': 'http://purl.obolibrary.org/obo/HP_0032530', 'lbl': 'Decreased succinic semialdehyde dehydrogenase level', 'desc': 'label: Decreased succinic semialdehyde dehydrogenase level\ndefinition : Reduced level of succinic semialdehyde dehydrogenase (SSADH).\nsynonyms :\n'}


{'id': 'HP_0032531', 'url': 'http://purl.obolibrary.org/obo/HP_0032531', 'lbl': 'Elevated CSF gamma-aminobutyric acid concentration', 'desc': 'label: Elevated CSF gamma-aminobutyric acid concentration\ndefinition : \nsynonyms :Gamma-aminobutyric acid (GABA) high in CSF\n'}


{'id': 'HP_0032532', 'url': 'http://purl.obolibrary.org/obo/HP_0032532', 'lbl': 'Elevated CSF 4-hydroxybutyric acid concentration', 'desc': 'label: Elevated CSF 4-hydroxybutyric acid concentration\ndefinition : Abnormally increased level of 4-hydroxybutyric acid in the cerebrospinal fluid (CSF).\nsynonyms :Elevated CSF GHB levels; Elevated CSF gamma-hydroxybutyric acid\n'}


{'id': 'HP_0032533', 'url': 'http://purl.obolibrary.org/obo/HP_0032533', 'lbl': 'Elevated circulating acetone concentration', 'desc': 'label: Elevated circulating acetone concentration\ndefinition : An increased level of acetone in the blood circulation. Acetone is one of the predominant ketone bodies.\nsynonyms :\n'}


{'id': 'HP_0032534', 'url': 'http://purl.obolibrary.org/obo/HP_0032534', 'lbl': 'Exacerbated by methylxanthine ingestion', 'desc': 'label: Exacerbated by methylxanthine ingestion\ndefinition : Applied to a sign or symptom that is worsened by ingestion of food containing a methylxanthine compound (for instance, coffee, caffeine, chocolate).\nsynonyms :Methylxanthines produce worsening\n'}


{'id': 'HP_0032535', 'url': 'http://purl.obolibrary.org/obo/HP_0032535', 'lbl': 'Cervical (neck)', 'desc': 'label: Cervical (neck)\ndefinition : Applies to an abnormality that is situated in the neck.\nsynonyms :\n'}


{'id': 'HP_0032536', 'url': 'http://purl.obolibrary.org/obo/HP_0032536', 'lbl': 'Increased number of lymph nodes', 'desc': 'label: Increased number of lymph nodes\ndefinition : An abnormally elevated number of lymph nodes in an anatomical region.\nsynonyms :\n'}


{'id': 'HP_0032537', 'url': 'http://purl.obolibrary.org/obo/HP_0032537', 'lbl': 'Delayed fracture healing', 'desc': 'label: Delayed fracture healing\ndefinition : A delay in healing of a fracture past the expected duration.\nsynonyms :\n'}


{'id': 'HP_0032538', 'url': 'http://purl.obolibrary.org/obo/HP_0032538', 'lbl': 'Pretibial dimple', 'desc': 'label: Pretibial dimple\ndefinition : A groove or crease on the shins (pretibial, i.e., over the shin bone). Pretibial creases may be obvious at birth and may range from 3 cm to over 15 cm in length and lenghten as the limb grows. They appear as an elongated dimple because of the attachment of skin to underlying tissue (e.g., to the tibia). The dimple or crease grows in proportion to the growth of the leg.\nsynonyms :\n'}


{'id': 'HP_0032539', 'url': 'http://purl.obolibrary.org/obo/HP_0032539', 'lbl': 'Joint extensor surface localization', 'desc': 'label: Joint extensor surface localization\ndefinition : Applies to an abnormality that is situated in extensor surface of the joint. The extensor surface refers to the skin on the opposite side of a joint.\nsynonyms :\n'}


{'id': 'HP_0032540', 'url': 'http://purl.obolibrary.org/obo/HP_0032540', 'lbl': 'Joint flexor surface localization', 'desc': 'label: Joint flexor surface localization\ndefinition : Applies to an abnormality that is situated in flexor surface of the joint. The flexor surface refers to the skin that touches when a joint is bent (flexed).\nsynonyms :\n'}


{'id': 'HP_0032541', 'url': 'http://purl.obolibrary.org/obo/HP_0032541', 'lbl': 'Knuckle pad', 'desc': 'label: Knuckle pad\ndefinition : Knuckle pads are benign fibrofatty subcutaneous pads located over the proximal interphalangeal (PIP) joints that can be mistaken for arthritis. Rarely they affect the dorsal aspect of the metacarpophalangeal (MCP) joints. Clinically they are painless and often affect both hands in an asymmetrical pattern.\nsynonyms :Knuckle pads on dorsal aspect of finger joints\n'}


{'id': 'HP_0032542', 'url': 'http://purl.obolibrary.org/obo/HP_0032542', 'lbl': 'Exacerbated by pregnancy', 'desc': 'label: Exacerbated by pregnancy\ndefinition : Applied to a sign or symptom that is worsened by being pregnant.\nsynonyms :\n'}


{'id': 'HP_0032543', 'url': 'http://purl.obolibrary.org/obo/HP_0032543', 'lbl': 'Lithoptysis', 'desc': 'label: Lithoptysis\ndefinition : Expectoration (coughing up) of a broncholith. Broncholithiasis is defined as the presence of calculi in the tracheobronchial tree. It is a rare disease but can be characterized by clinical and radiological findings of a calcified lymph node eroding bronchial wall and opening into the bronchial lumen.\nsynonyms :\n'}


{'id': 'HP_0032544', 'url': 'http://purl.obolibrary.org/obo/HP_0032544', 'lbl': 'Predominant small joint localization', 'desc': 'label: Predominant small joint localization\ndefinition : Applies to an abnormality that mainly affects the small joints, including fingers, toes, interphalangeal, metacarpophalangeal, metatarsophalangeal, wrists, ankles, vertebrae, and neck.\nsynonyms :\n'}


{'id': 'HP_0032545', 'url': 'http://purl.obolibrary.org/obo/HP_0032545', 'lbl': 'Abdominal rigidity', 'desc': 'label: Abdominal rigidity\ndefinition : Involuntary tightening of the abdominal musculature that occurs in response to touching the abdomen to avoid pain. Rigidity can occur in the presence of abdominal inflammation and usually involves only the inflamed area.\nsynonyms :Rigid abdomen\n'}


{'id': 'HP_0032546', 'url': 'http://purl.obolibrary.org/obo/HP_0032546', 'lbl': 'Abdominal guarding', 'desc': 'label: Abdominal guarding\ndefinition : A voluntary contraction of the abdominal wall musculature to avoid pain.\nsynonyms :\n'}


{'id': 'HP_0032547', 'url': 'http://purl.obolibrary.org/obo/HP_0032547', 'lbl': 'Low intraocular pressure', 'desc': 'label: Low intraocular pressure\ndefinition : An abnormal decrease of the pressure within the eye.\nsynonyms :Ocular hypotony\n'}


{'id': 'HP_0032548', 'url': 'http://purl.obolibrary.org/obo/HP_0032548', 'lbl': 'Increased placental thickness', 'desc': 'label: Increased placental thickness\ndefinition : Abnormally elevated placental thickness.\nsynonyms :Placental thickness increased\n'}


{'id': 'HP_0032549', 'url': 'http://purl.obolibrary.org/obo/HP_0032549', 'lbl': 'Persistent asymmetrical tonic neck reflex', 'desc': "label: Persistent asymmetrical tonic neck reflex\ndefinition : Persistence beyond the normal age (roughly the first half of the first year of life) of the asymmetric tonic neck reflex (ATNR), which is an easily elicited primitive reflex in the immediate newborn period. The ATNR refers to the phenomenon whereby when the face of an infant is turned to one side, the ipsilateral arm and leg extend and the contralateral arm and leg flex. This posture has been compared to a typical posture of fencers.\nsynonyms :Persistent fencer's reflex; Tonic neck reflex asymmetrical and persistent\n"}


{'id': 'HP_0032550', 'url': 'http://purl.obolibrary.org/obo/HP_0032550', 'lbl': 'Howell-Jolly bodies', 'desc': 'label: Howell-Jolly bodies\ndefinition : Howell-Jolly bodies are small, intra-erythrocytic remnants of erythrocyte nuclei. These inclusions are solitary in each erythrocyte and strongly basophilic. These are often confused with overlying platelets, but can be distinguished by the presence of a halo around overlying platelets.\nsynonyms :\n'}


{'id': 'HP_0032551', 'url': 'http://purl.obolibrary.org/obo/HP_0032551', 'lbl': 'Hemorrhoids', 'desc': 'label: Hemorrhoids\ndefinition : Enlarged, bulging blood vessels in and around the anus often associated with rectal bleeding, itching, and pain.\nsynonyms :Haemorrhoids; Piles\n'}


{'id': 'HP_0032552', 'url': 'http://purl.obolibrary.org/obo/HP_0032552', 'lbl': 'Abnormal pulse', 'desc': 'label: Abnormal pulse\ndefinition : An anomaly of the rhythmic throbbing of an artery that reflects the widening of the artery as blood flows through it and is caused by successive contractions of the heart.\nsynonyms :\n'}


{'id': 'HP_0032553', 'url': 'http://purl.obolibrary.org/obo/HP_0032553', 'lbl': 'Weak pulse', 'desc': 'label: Weak pulse\ndefinition : A diminution in the amplitude (strength) of the pulse such that the examiner has difficulty feeling the pulse.\nsynonyms :\n'}


{'id': 'HP_0032554', 'url': 'http://purl.obolibrary.org/obo/HP_0032554', 'lbl': 'Absent pulse', 'desc': 'label: Absent pulse\ndefinition : The pulsation of an artery where the pulse is taken (e.g. the radial artery at the wrist) cannot be detected on physical examination.\nsynonyms :\n'}


{'id': 'HP_0032555', 'url': 'http://purl.obolibrary.org/obo/HP_0032555', 'lbl': 'Bounding pulse', 'desc': 'label: Bounding pulse\ndefinition : Increased amplitude (strength) of the pulse.\nsynonyms :\n'}


{'id': 'HP_0032556', 'url': 'http://purl.obolibrary.org/obo/HP_0032556', 'lbl': 'Circumoral cyanosis', 'desc': 'label: Circumoral cyanosis\ndefinition : Persistent blue color of the skin that surrounds the mouth.\nsynonyms :Bluish around mouth\n'}


{'id': 'HP_0032557', 'url': 'http://purl.obolibrary.org/obo/HP_0032557', 'lbl': 'History of bone marrow transplant', 'desc': 'label: History of bone marrow transplant\ndefinition : A past medical history of hematopoietic stem cell transplantation involving myeloablative chemoradiotherapy followed by stem cell rescue with autologous or human leukocyte antigen (HLA)-matched stem cells derived from a donor.\nsynonyms :Status post haematopoietic stem cell transplantation; Status post hematopoietic stem cell transplantation\n'}


{'id': 'HP_0032558', 'url': 'http://purl.obolibrary.org/obo/HP_0032558', 'lbl': 'Absent sperm flagella', 'desc': 'label: Absent sperm flagella\ndefinition : Sperm cells lacking flagella.\nsynonyms :\n'}


{'id': 'HP_0032559', 'url': 'http://purl.obolibrary.org/obo/HP_0032559', 'lbl': 'Short sperm flagella', 'desc': 'label: Short sperm flagella\ndefinition : Sperm cells with abnormally short flagella.\nsynonyms :\n'}


{'id': 'HP_0032560', 'url': 'http://purl.obolibrary.org/obo/HP_0032560', 'lbl': 'Coiled sperm flagella', 'desc': 'label: Coiled sperm flagella\ndefinition : Sperm cells whose flagella are twisted (coiled).\nsynonyms :\n'}


{'id': 'HP_0032561', 'url': 'http://purl.obolibrary.org/obo/HP_0032561', 'lbl': 'Microcephalic sperm head', 'desc': 'label: Microcephalic sperm head\ndefinition : Decreased size of the head of sperm.\nsynonyms :Small-head sperm\n'}


{'id': 'HP_0032562', 'url': 'http://purl.obolibrary.org/obo/HP_0032562', 'lbl': 'Tapered sperm head', 'desc': 'label: Tapered sperm head\ndefinition : Sperm with cigar-shaped heads that gradually dimish in diameter (taper).\nsynonyms :\n'}


{'id': 'HP_0032563', 'url': 'http://purl.obolibrary.org/obo/HP_0032563', 'lbl': 'Dacryocytosis', 'desc': 'label: Dacryocytosis\ndefinition : Presence of teardrop-shaped red blood cells.\nsynonyms :Dacryocytes; Tear-drop shaped erythrocytes\n'}


{'id': 'HP_0032564', 'url': 'http://purl.obolibrary.org/obo/HP_0032564', 'lbl': 'Ileitis', 'desc': 'label: Ileitis\ndefinition : Inflammation of the ileum.\nsynonyms :Inflammation of the ileum\n'}


{'id': 'HP_0032565', 'url': 'http://purl.obolibrary.org/obo/HP_0032565', 'lbl': 'Vaginal mucosal ulceration', 'desc': 'label: Vaginal mucosal ulceration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032566', 'url': 'http://purl.obolibrary.org/obo/HP_0032566', 'lbl': 'Oval macrocytosis', 'desc': 'label: Oval macrocytosis\ndefinition : Enlarged, oval-shaped erythrocytes (red blood cells).\nsynonyms :\n'}


{'id': 'HP_0032567', 'url': 'http://purl.obolibrary.org/obo/HP_0032567', 'lbl': 'Lipiduria', 'desc': 'label: Lipiduria\ndefinition : An increased lipid content in the urine.\nsynonyms :Urinary lipid excretion\n'}


{'id': 'HP_0032568', 'url': 'http://purl.obolibrary.org/obo/HP_0032568', 'lbl': 'Urinary mulberry cells', 'desc': 'label: Urinary mulberry cells\ndefinition : Distal tubular epithelial cells in which globotriaosylceramide (Gb3) has accumulated. they are the characteristic feature of Fabry disease. Urinary mulberry bodies are a component of mulberry cells that can be distinguished easily from fat particles by their inner lamellar appearance.\nsynonyms :\n'}


{'id': 'HP_0032569', 'url': 'http://purl.obolibrary.org/obo/HP_0032569', 'lbl': 'Temporal bossing', 'desc': 'label: Temporal bossing\ndefinition : Prominence (bulging) in the temple region, which is the part of the skull where the frontal, parietal, temporal, and sphenoid bones join on the side of the head.\nsynonyms :\n'}


{'id': 'HP_0032570', 'url': 'http://purl.obolibrary.org/obo/HP_0032570', 'lbl': 'Pontine ischemic lacunes', 'desc': 'label: Pontine ischemic lacunes\ndefinition : Lacunes are infarcts less than 15 mm in diameter in the cortical white matter or in the corona radiata, internal capsule, centrum semiovale, thalamus, basal ganglia, or pons.\nsynonyms :Pontine ischaemic lacunes\n'}


{'id': 'HP_0032571', 'url': 'http://purl.obolibrary.org/obo/HP_0032571', 'lbl': 'Increased oocyte death', 'desc': 'label: Increased oocyte death\ndefinition : An increase in death of oocytes, the female germ cell (egg cell), which can be observed clinically in the setting of in vitro fertilization.\nsynonyms :\n'}


{'id': 'HP_0032572', 'url': 'http://purl.obolibrary.org/obo/HP_0032572', 'lbl': 'Abnormal urinary nucleobase concentration', 'desc': 'label: Abnormal urinary nucleobase concentration\ndefinition : A deviation from the normal level of a nucleobase in the urine. Nucleobases are nitrogen-containing biological compounds that form nucleosides: adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U).\nsynonyms :\n'}


{'id': 'HP_0032573', 'url': 'http://purl.obolibrary.org/obo/HP_0032573', 'lbl': 'Elevated urinary cytidine', 'desc': 'label: Elevated urinary cytidine\ndefinition : Increased levels of urinary cytidine, a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N1 glycosidic bond.\nsynonyms :\n'}


{'id': 'HP_0032574', 'url': 'http://purl.obolibrary.org/obo/HP_0032574', 'lbl': 'Elevated urinary uridine level', 'desc': 'label: Elevated urinary uridine level\ndefinition : Increased levels of urinary uridine, a ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N1 glycosidic bond.\nsynonyms :Elevated uridine in urine\n'}


{'id': 'HP_0032575', 'url': 'http://purl.obolibrary.org/obo/HP_0032575', 'lbl': 'Decreased circulating 12-HETE', 'desc': 'label: Decreased circulating 12-HETE\ndefinition : A reduction in the concentration of 12-HETE in the blood circulation, a metabolite of arachidonic acid.\nsynonyms :Decreased circulating 12-Hydroxyeicosatetraenoic acid concentration\n'}


{'id': 'HP_0032576', 'url': 'http://purl.obolibrary.org/obo/HP_0032576', 'lbl': 'Intracellular accumulation of Dol-PP-GlcNAc2Man5', 'desc': 'label: Intracellular accumulation of Dol-PP-GlcNAc2Man5\ndefinition : Intracellular accumulation of the lipid-linked oligosaccharide intermediate Man5GlcNAc2-PP-dolichol.\nsynonyms :\n'}


{'id': 'HP_0032577', 'url': 'http://purl.obolibrary.org/obo/HP_0032577', 'lbl': 'Clonal T cell receptor rearrangement', 'desc': 'label: Clonal T cell receptor rearrangement\ndefinition : Presence of a predominant T cell clone. In PCR-based assays, this finding is inferred on the basis of one or two prominent bands within a valid size range. In NGS-based assays, this finding is inferred on the basis of a high number of reads that map to a single T cell receptor clone.\nsynonyms :\n'}


{'id': 'HP_0032578', 'url': 'http://purl.obolibrary.org/obo/HP_0032578', 'lbl': 'Third ventricle colloid cyst', 'desc': 'label: Third ventricle colloid cyst\ndefinition : An epithelial lined cyst filled with gelatinous material. The gelatinous material commonly contains mucin, old blood, cholesterol, and ions. Most colloid cysts identified are currently asymptomatic and identified incidentally on imaging. When a colloid cyst does cause issues, it most commonly causes obstructive hydrocephalus.\nsynonyms :\n'}


{'id': 'HP_0032579', 'url': 'http://purl.obolibrary.org/obo/HP_0032579', 'lbl': 'Vascular hamartoma', 'desc': 'label: Vascular hamartoma\ndefinition : A benign focal growth composed of vascular tissue.\nsynonyms :\n'}


{'id': 'HP_0032580', 'url': 'http://purl.obolibrary.org/obo/HP_0032580', 'lbl': 'Abnormal bulbus cordis morphology', 'desc': 'label: Abnormal bulbus cordis morphology\ndefinition : Abnormal structure of the bulbus cordis, which is the single outflow tract of the heart during early embryogenesis.\nsynonyms :\n'}


{'id': 'HP_0032581', 'url': 'http://purl.obolibrary.org/obo/HP_0032581', 'lbl': 'Abnormal renal insterstitial morphology', 'desc': 'label: Abnormal renal insterstitial morphology\ndefinition : Any structural anomaly of the interstitium of the kidney. The renal interstitium is defined as the intertubular, extraglomerular, extravascular space of the kidney. It is bounded on all sides by tubular and vascular basement membranes and is filled with cells, extracellular matrix, and interstitial fluid.\nsynonyms :\n'}


{'id': 'HP_0032582', 'url': 'http://purl.obolibrary.org/obo/HP_0032582', 'lbl': 'Renal interstitial foam cells', 'desc': 'label: Renal interstitial foam cells\ndefinition : Accumulation of foam cells (FC) in the interstitium of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles.\nsynonyms :\n'}


{'id': 'HP_0032583', 'url': 'http://purl.obolibrary.org/obo/HP_0032583', 'lbl': 'Renal glomerular foam cells', 'desc': 'label: Renal glomerular foam cells\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032584', 'url': 'http://purl.obolibrary.org/obo/HP_0032584', 'lbl': 'Renal interstitial neutrophil infiltration', 'desc': 'label: Renal interstitial neutrophil infiltration\ndefinition : Increased numbers of neutrophils in the interstitial tissues of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032585', 'url': 'http://purl.obolibrary.org/obo/HP_0032585', 'lbl': 'Renal interstitial eosinophil infiltration', 'desc': 'label: Renal interstitial eosinophil infiltration\ndefinition : Increased numbers of eosinophils in the interstitial tissues of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032586', 'url': 'http://purl.obolibrary.org/obo/HP_0032586', 'lbl': 'Renal interstitial plasma cell infiltration', 'desc': 'label: Renal interstitial plasma cell infiltration\ndefinition : Increased numbers of plasma cells in the interstitial tissues of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032587', 'url': 'http://purl.obolibrary.org/obo/HP_0032587', 'lbl': 'Renal interstitial calcium oxalate', 'desc': 'label: Renal interstitial calcium oxalate\ndefinition : The presence of birefringent calcium- and oxalate deposits in interstitial cells of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032588', 'url': 'http://purl.obolibrary.org/obo/HP_0032588', 'lbl': 'Hand apraxia', 'desc': 'label: Hand apraxia\ndefinition : Inability to perform purposeful (learned) movements with the hand upon command, even though the command is understood and there is a willingness to perform the movement. Hand apraxia includes the inability to grasp, pick up, and hold large and small objects.\nsynonyms :Lack of purposeful hand use\n'}


{'id': 'HP_0032589', 'url': 'http://purl.obolibrary.org/obo/HP_0032589', 'lbl': 'Renal lymphocytic tubulitis', 'desc': 'label: Renal lymphocytic tubulitis\ndefinition : Infiltration of the renal tubular epithelium by lymphocytes.\nsynonyms :\n'}


{'id': 'HP_0032590', 'url': 'http://purl.obolibrary.org/obo/HP_0032590', 'lbl': 'Renal neutrophilic tubulitis', 'desc': 'label: Renal neutrophilic tubulitis\ndefinition : Infiltration of the renal tubular epithelium by neutrophils.\nsynonyms :\n'}


{'id': 'HP_0032591', 'url': 'http://purl.obolibrary.org/obo/HP_0032591', 'lbl': 'Renal interstitial hemosiderin', 'desc': 'label: Renal interstitial hemosiderin\ndefinition : Deposition of hemosiderin (a golden-brown, granular pigment derived from ferritin) in interstitial cells of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032592', 'url': 'http://purl.obolibrary.org/obo/HP_0032592', 'lbl': 'Aplasia of the right hemidiaphragm', 'desc': 'label: Aplasia of the right hemidiaphragm\ndefinition : Congenital absence of the right-sided diaphragm.\nsynonyms :Right diaphragmatic hernia\n'}


{'id': 'HP_0032593', 'url': 'http://purl.obolibrary.org/obo/HP_0032593', 'lbl': 'Myoglobin casts', 'desc': 'label: Myoglobin casts\ndefinition : A type of acelluar casts with positive myoglobin staining A that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented.\nsynonyms :\n'}


{'id': 'HP_0032594', 'url': 'http://purl.obolibrary.org/obo/HP_0032594', 'lbl': 'Renal tubular basement membrane denudation', 'desc': 'label: Renal tubular basement membrane denudation\ndefinition : Naked basement membranes without tubular epithelium.\nsynonyms :Denuded tubular basement membrane\n'}


{'id': 'HP_0032595', 'url': 'http://purl.obolibrary.org/obo/HP_0032595', 'lbl': 'Renal tubular epithelial cell detachment', 'desc': 'label: Renal tubular epithelial cell detachment\ndefinition : Tubular cross section with a space between the basolateral aspect of tubular epithelium and its basement membrane; classified as global when at least 2/3 circumference of the tubular cross section are involved and segmental when less than 2/3 are involved.\nsynonyms :\n'}


{'id': 'HP_0032596', 'url': 'http://purl.obolibrary.org/obo/HP_0032596', 'lbl': 'Renal tubular epithelial cell cytoplasmic vacuolization', 'desc': 'label: Renal tubular epithelial cell cytoplasmic vacuolization\ndefinition : Tubular cross section with intracytoplasmic vacuoles in at least one tubular epithelial cell. This feature is classified as isometric when vacuoles are round and similar in size and coarse when vacuoles were not round in shape or varied in size.\nsynonyms :\n'}


{'id': 'HP_0032597', 'url': 'http://purl.obolibrary.org/obo/HP_0032597', 'lbl': 'Renal tubular epithelial cell sloughing', 'desc': 'label: Renal tubular epithelial cell sloughing\ndefinition : At least one free floating cell in the tubular lumen without attachment to adjacent cells or basement membrane in a tubular cross section without detachment. These cells must not aggregate into a tubular shape and completely fill the lumen, if so, it should be classified as a cast.\nsynonyms :\n'}


{'id': 'HP_0032598', 'url': 'http://purl.obolibrary.org/obo/HP_0032598', 'lbl': 'Blebbing of apical cytoplasm of renal tubular epithelial cells', 'desc': 'label: Blebbing of apical cytoplasm of renal tubular epithelial cells\ndefinition : Tubular cross section with round/irregular cytoplasmic protrusion, shaped like the Greek capital letter Omega (or it may be more vertically elongated Omega), pinched off from apical membrane without apparent closure of the lumen, involving over 50 percent of the tubular cells in cross section. The feature can be further classified into proximal or distal tubule.\nsynonyms :\n'}


{'id': 'HP_0032599', 'url': 'http://purl.obolibrary.org/obo/HP_0032599', 'lbl': 'Abnormal renal tubular epithelial morphology', 'desc': 'label: Abnormal renal tubular epithelial morphology\ndefinition : Any structural anomaly of the renal tubular epithelial cells (RTEC), a layer of cells in the outer layer of the renal tubule. These cells play a role in the absorption of substances such as glucose and amino from the primary urine.\nsynonyms :\n'}


{'id': 'HP_0032600', 'url': 'http://purl.obolibrary.org/obo/HP_0032600', 'lbl': 'Renal tubular epithelial cell hyaline droplets', 'desc': 'label: Renal tubular epithelial cell hyaline droplets\ndefinition : Tubular epithelium with round strongly PAS-positive cytoplasmic droplet material in at least one tubular epithelial cell.\nsynonyms :\n'}


{'id': 'HP_0032601', 'url': 'http://purl.obolibrary.org/obo/HP_0032601', 'lbl': 'Multinucleation of renal tubular epithelial cells', 'desc': 'label: Multinucleation of renal tubular epithelial cells\ndefinition : Tubular epithelial cells with greater than 3 nuclei in a single epithelial cell, often overlapping with each other in a single plane of view.\nsynonyms :\n'}


{'id': 'HP_0032602', 'url': 'http://purl.obolibrary.org/obo/HP_0032602', 'lbl': 'Prominent nucleoli of renal tubular epithelial cells', 'desc': 'label: Prominent nucleoli of renal tubular epithelial cells\ndefinition : Tubular epithelium with nucleoli clearly visible at 100-fold magnification.\nsynonyms :\n'}


{'id': 'HP_0032603', 'url': 'http://purl.obolibrary.org/obo/HP_0032603', 'lbl': 'Renal tubular epithelial cell simplification', 'desc': 'label: Renal tubular epithelial cell simplification\ndefinition : Tubular cross section with flattened tubular cell cytoplasm (height unequivocally less than width), with complete loss of brush border involving greater than 50 percent of the tubular cells in cross section, resulting in an apparent increase in the size of the lumen, without the presence of casts.\nsynonyms :\n'}


{'id': 'HP_0032604', 'url': 'http://purl.obolibrary.org/obo/HP_0032604', 'lbl': 'Renal tubular epithelial cell mitosis', 'desc': 'label: Renal tubular epithelial cell mitosis\ndefinition : Tubular epithelial cells in any mitotic phase, identified by distinctively visible chromosome in either prophase, metaphase, anaphase or telophase configuration.\nsynonyms :\n'}


{'id': 'HP_0032605', 'url': 'http://purl.obolibrary.org/obo/HP_0032605', 'lbl': 'High renal tubular epithelial cell N/C ratio', 'desc': 'label: High renal tubular epithelial cell N/C ratio\ndefinition : At least one tubular epithelial cell with average sized cytoplasmic area and a nuclear area 3 times greater than average sized nuclei.\nsynonyms :High N/C ratio of renal tubular epithelial cells\n'}


{'id': 'HP_0032606', 'url': 'http://purl.obolibrary.org/obo/HP_0032606', 'lbl': 'Renal tubular epithelial lipofuscin', 'desc': 'label: Renal tubular epithelial lipofuscin\ndefinition : Presence of increased amount of lipofuscin, a yellow, granular cytoplasmic pigment in the renal tubules.\nsynonyms :\n'}


{'id': 'HP_0032607', 'url': 'http://purl.obolibrary.org/obo/HP_0032607', 'lbl': 'Renal tubular epithelial cell swelling', 'desc': 'label: Renal tubular epithelial cell swelling\ndefinition : Tubular cross section lined entirely by tubular epithelium with convex apical cell membrane (i.e., cells are shaped like an upside down U, and lack a distinct smaller protrusion seen in blebbing as defined above) resulting in apparent complete closure of the lumen.\nsynonyms :\n'}


{'id': 'HP_0032608', 'url': 'http://purl.obolibrary.org/obo/HP_0032608', 'lbl': 'Thyroidization-type tubular atrophy', 'desc': 'label: Thyroidization-type tubular atrophy\ndefinition : A type of renal tubular atrophy characterized by a thyroid-like appearance, with small round tubules with markedly flattened, simplified epithelium and uniform intratubular casts.\nsynonyms :\n'}


{'id': 'HP_0032609', 'url': 'http://purl.obolibrary.org/obo/HP_0032609', 'lbl': 'Endocrine-type tubular atrophy', 'desc': 'label: Endocrine-type tubular atrophy\ndefinition : A type of renal tubular atrophy characterized by endocrine-like appearance of tubules, which are small and have narrow lumina, clear cells, and relatively thin basement membranes.\nsynonyms :Endocrinization pattern of tubular atrophy; Renal tubular atrophy, endocrine-type\n'}


{'id': 'HP_0032610', 'url': 'http://purl.obolibrary.org/obo/HP_0032610', 'lbl': 'Tubulointerstitial mycobacterial infiltration', 'desc': 'label: Tubulointerstitial mycobacterial infiltration\ndefinition : Renal tubulointerstitial infiltration of mycobacteria identified on acid-fast or Fite stains. Can be associated with granulomatous inflammation.\nsynonyms :Renal tubulointerstitial mycobacterial organisms\n'}


{'id': 'HP_0032611', 'url': 'http://purl.obolibrary.org/obo/HP_0032611', 'lbl': 'Renal tubular epithelial cell hemosiderin', 'desc': 'label: Renal tubular epithelial cell hemosiderin\ndefinition : Tubular epithelial cells containing cytoplasmic hemosiderin, brown-golden granular pigment.\nsynonyms :\n'}


{'id': 'HP_0032612', 'url': 'http://purl.obolibrary.org/obo/HP_0032612', 'lbl': 'Triphalangeal hallux', 'desc': 'label: Triphalangeal hallux\ndefinition : A hallux (big toe) with three phalanges in a single, proximo-distal axis.\nsynonyms :\n'}


{'id': 'HP_0032613', 'url': 'http://purl.obolibrary.org/obo/HP_0032613', 'lbl': 'Renal interstitial amyloid deposits', 'desc': 'label: Renal interstitial amyloid deposits\ndefinition : Deposition of amyloid in the interstitial tissue of the kidney. Amyloid is is made up of 10 nm (on average) fibrils that are most commonly composed of monoclonal light chains (AL), transthyretin (TTR), amd LECT2, or occur in the setting of long standing systemic inflammation.\nsynonyms :Renal interstitial amyloid; Renal interstitial amyloid deposition; Renal interstitial amyloidosis\n'}


{'id': 'HP_0032614', 'url': 'http://purl.obolibrary.org/obo/HP_0032614', 'lbl': 'Renal glomerular amyloid deposition', 'desc': 'label: Renal glomerular amyloid deposition\ndefinition : Amyloid deposits located in the glomeruli in a focal segmental, diffuse segmental or diffuse global fashion. This abnormality can be accompanied by mesangial involvement and in later stages also involvement of the peripheral capillaries.\nsynonyms :\n'}


{'id': 'HP_0032615', 'url': 'http://purl.obolibrary.org/obo/HP_0032615', 'lbl': 'Abnormal diffusion weighted cerebral MRI morphology', 'desc': 'label: Abnormal diffusion weighted cerebral MRI morphology\ndefinition : A diffusion abnormality observed in diffusion-weighted magnetic resonance imaging (MRI) of the brain. Molecular diffusion refers to the notion that any type of molecule in a fluid (eg, water) is randomly displaced as the molecule is agitated by thermal energy. Restricted diffusion of water appears bright on diffusion-weighted images.\nsynonyms :Diffusion weighted imaging (DWI) abnormality; Diffusion weighted magnetic resonance imaging (DWI) abnormality; MRI diffusion abnormality of the cerebrum\n'}


{'id': 'HP_0032616', 'url': 'http://purl.obolibrary.org/obo/HP_0032616', 'lbl': 'Renal interstitial immunoglobulin deposits', 'desc': 'label: Renal interstitial immunoglobulin deposits\ndefinition : Accumulation of an immunoglobulin in the interstitial tissue of the kidney. The immunoglobulin may be a monoclonal Ig or the corresponding heavy-chain (HC) or light-chain (LC) subunit. By convention this definition excludes Ig-derived amyloidosis (amyloidosis can be distinguished by its affinity for Congo red staining).\nsynonyms :Renal interstitial immunoglobulin deposition\n'}


{'id': 'HP_0032617', 'url': 'http://purl.obolibrary.org/obo/HP_0032617', 'lbl': 'Renal interstitial hemorrhage', 'desc': 'label: Renal interstitial hemorrhage\ndefinition : A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core.\nsynonyms :Renal interstitial haemorrhage\n'}


{'id': 'HP_0032618', 'url': 'http://purl.obolibrary.org/obo/HP_0032618', 'lbl': 'Renal necrosis', 'desc': 'label: Renal necrosis\ndefinition : Cell death (necrosis) affecting one or more parts of the kidney.\nsynonyms :Renal parenchymal necrosis\n'}


{'id': 'HP_0032619', 'url': 'http://purl.obolibrary.org/obo/HP_0032619', 'lbl': 'Perinephric abscess', 'desc': 'label: Perinephric abscess\ndefinition : A perinephric abscess is a collection of suppurative material in the perinephric space (i.e., the connective and adipose tissues surrounding the kidney).\nsynonyms :\n'}


{'id': 'HP_0032620', 'url': 'http://purl.obolibrary.org/obo/HP_0032620', 'lbl': 'Intrarenal abscess', 'desc': 'label: Intrarenal abscess\ndefinition : An encapsulated collection of pus and necrotic material within the renal parenchyma. The destruction of renal parenchyma is associated with suppurative/neutrophil-rich inflammation and necrosis.\nsynonyms :Renal abscess; Renal parenchymal abcess\n'}


{'id': 'HP_0032621', 'url': 'http://purl.obolibrary.org/obo/HP_0032621', 'lbl': 'Hyperchromasia of renal tubular epithelial cells', 'desc': 'label: Hyperchromasia of renal tubular epithelial cells\ndefinition : At least one tubular cross section with all tubular epithelial nuclei having a chromatin pattern resembling normal mature lymphocytes.\nsynonyms :Condensed chromatin of renal tubular epithelial cells\n'}


{'id': 'HP_0032622', 'url': 'http://purl.obolibrary.org/obo/HP_0032622', 'lbl': 'Tubular luminal dilatation', 'desc': 'label: Tubular luminal dilatation\ndefinition : Dilatation (expansion beyond the normal dimension) of the cavity (lumen) of tubules of the kidney. The tubular cross section displays an attenuated brush border (apical PAS positivity greater than 10 percent of the normal expected height, but unequivocally less than normal expected height), resulting in an apparent increase in the size of lumen.\nsynonyms :Tubular ectasia\n'}


{'id': 'HP_0032623', 'url': 'http://purl.obolibrary.org/obo/HP_0032623', 'lbl': 'Renal intratubular casts', 'desc': 'label: Renal intratubular casts\ndefinition : Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. This term refers to casts located within the tubuli of the kidney. More precisely, casts are defined as a material that completely fills and expands the tubular lumen with simplification of surrounding tubular epithelium. Casts are classified as either nuclear debris/granular brown material, red blood cell, white blood cell, myeloma, or myoglobin cast.\nsynonyms :Tubular casts\n'}


{'id': 'HP_0032624', 'url': 'http://purl.obolibrary.org/obo/HP_0032624', 'lbl': 'Intratubular bilirubin casts', 'desc': 'label: Intratubular bilirubin casts\ndefinition : A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. On H&E (red brown), PAS (amaranth purple), trichrome (red with ragged contours), Hall (olive-emerald green).\nsynonyms :\n'}


{'id': 'HP_0032625', 'url': 'http://purl.obolibrary.org/obo/HP_0032625', 'lbl': 'Intratubular erythrocyte cast', 'desc': 'label: Intratubular erythrocyte cast\ndefinition : Casts that contain red blood cells and are located within the tubuli of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032626', 'url': 'http://purl.obolibrary.org/obo/HP_0032626', 'lbl': 'Intratubular vancomycin casts', 'desc': 'label: Intratubular vancomycin casts\ndefinition : Intratubular casts composed of vancomycin aggregates and uromodulin.\nsynonyms :\n'}


{'id': 'HP_0032627', 'url': 'http://purl.obolibrary.org/obo/HP_0032627', 'lbl': 'Intratubular leukocyte casts', 'desc': 'label: Intratubular leukocyte casts\ndefinition : Casts that contain white blood cells and are located within the tubuli of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032628', 'url': 'http://purl.obolibrary.org/obo/HP_0032628', 'lbl': 'Renal intratubular crystals', 'desc': 'label: Renal intratubular crystals\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032629', 'url': 'http://purl.obolibrary.org/obo/HP_0032629', 'lbl': 'Intratubular dihydroxyadenuria crystals', 'desc': 'label: Intratubular dihydroxyadenuria crystals\ndefinition : Intratubular crystals composed of 2,8-dihydroxyadenine are small needle-shaped brownish crystals that are highly birefringent under polarized light and black by Jones methenamine silver.\nsynonyms :\n'}


{'id': 'HP_0032630', 'url': 'http://purl.obolibrary.org/obo/HP_0032630', 'lbl': 'Intratubular light-chain casts', 'desc': 'label: Intratubular light-chain casts\ndefinition : The presence of casts containing immunoglobulin light chains within the lumina of the renal tubules.\nsynonyms :\n'}


{'id': 'HP_0032631', 'url': 'http://purl.obolibrary.org/obo/HP_0032631', 'lbl': 'Intratubular hemoglobin casts', 'desc': 'label: Intratubular hemoglobin casts\ndefinition : A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented. On H&E (red granular), PAS (purple), trichrome (red granular), Hall (yellow brown). Stain positively for Hemoglobin A.\nsynonyms :Intratubular haemoglobin casts\n'}


{'id': 'HP_0032632', 'url': 'http://purl.obolibrary.org/obo/HP_0032632', 'lbl': 'Renal papillary necrosis', 'desc': 'label: Renal papillary necrosis\ndefinition : Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei.\nsynonyms :\n'}


{'id': 'HP_0032633', 'url': 'http://purl.obolibrary.org/obo/HP_0032633', 'lbl': 'Intratubular hyaline casts', 'desc': 'label: Intratubular hyaline casts\ndefinition : A type of acellular urinary cast located within the distal tubules of the kidney and that is composed only of Tamm-Horsfall glycoprotein. Correspondingly, these casts have a low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends.\nsynonyms :Intratubular Tamm-Horsfall (uromodulin) casts\n'}


{'id': 'HP_0032634', 'url': 'http://purl.obolibrary.org/obo/HP_0032634', 'lbl': 'Intratubular myoglobin cast', 'desc': 'label: Intratubular myoglobin cast\ndefinition : Casts located within the tubuli of the kidney and that contain myoglobin. Myoglobin casts are composed of round granules that may line up in chains or aggregate in clusters. Their color ranges from pink to red-brown with hematoxylin and eosin stain, light brown to black with Jones methenamine silver stain, pink to bright magenta with periodic acid-Schiff stain, and bright red with trichrome stain. Immunoperoxidase staining with antibody to myoglobin is stronglypositive in the casts.Electron microscopy shows globular casts with an electron-dense core and a somewhat less-intense periphery. Substructure is absent. This feature may be accompanied by acute tubular injury with variable flattening of tubular epithelial cells, loss of brush borders, and intratubular sloughed epithelial cells.\nsynonyms :\n'}


{'id': 'HP_0032635', 'url': 'http://purl.obolibrary.org/obo/HP_0032635', 'lbl': 'Tubulointerstitial microganismal infiltration', 'desc': 'label: Tubulointerstitial microganismal infiltration\ndefinition : Infiltration of microorganisms into renal tubulointerstitial tissues as observed by appropriate staining procedures, e.g., bacteria on a bacterial stain (Brown and Hopps) or fungi on PAS or silver stain.\nsynonyms :\n'}


{'id': 'HP_0032636', 'url': 'http://purl.obolibrary.org/obo/HP_0032636', 'lbl': 'Tubulointerstitial viral infiltration', 'desc': 'label: Tubulointerstitial viral infiltration\ndefinition : Infiltration of viruses into renal tubulointerstitial tissues as demonstrated on renal biopsy by viral inclusions which can be seen on routine stains or with immunohistochemistry.\nsynonyms :Renal tubulointerstitial viral inclusions\n'}


{'id': 'HP_0032637', 'url': 'http://purl.obolibrary.org/obo/HP_0032637', 'lbl': 'Renal interstitial edema', 'desc': 'label: Renal interstitial edema\ndefinition : Edema is characterized but the acute swelling of the stroma, with expansion of the interstitial space without the a concurrent increase in interstitial cells or extracellular matrix. Histologically this change is appreciated as interstitial areas of lower optical density.\nsynonyms :Renal interstitial oedema\n'}


{'id': 'HP_0032638', 'url': 'http://purl.obolibrary.org/obo/HP_0032638', 'lbl': 'Elevated urine mevalonic acid level', 'desc': 'label: Elevated urine mevalonic acid level\ndefinition : An abnormally increased amount of mevanolate in the urine. Mevanolate is that hydroxy monocarboxylic acid anion that is the conjugate base of mevalonic acid.\nsynonyms :Elevated urine mevalonate; Elevated urine mevalonate levels; Elevated urine mevalonic acid; Mevalonate aciduria\n'}


{'id': 'HP_0032639', 'url': 'http://purl.obolibrary.org/obo/HP_0032639', 'lbl': 'Elevated leukocyte cystine', 'desc': 'label: Elevated leukocyte cystine\ndefinition : An increased concentration of cystine within white blood cells.\nsynonyms :\n'}


{'id': 'HP_0032640', 'url': 'http://purl.obolibrary.org/obo/HP_0032640', 'lbl': 'Elevated circulating CCL18 level', 'desc': 'label: Elevated circulating CCL18 level\ndefinition : An increased concentration of C-C motif chemokine ligand 18 in the blood circulation.\nsynonyms :Increased C-C motif chemokine ligand 18 concentration\n'}


{'id': 'HP_0032641', 'url': 'http://purl.obolibrary.org/obo/HP_0032641', 'lbl': 'Renal interstitial granulomas', 'desc': 'label: Renal interstitial granulomas\ndefinition : Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present.\nsynonyms :Renal interstitial granulomata\n'}


{'id': 'HP_0032642', 'url': 'http://purl.obolibrary.org/obo/HP_0032642', 'lbl': 'Renal interstitial necrotizing granulomas', 'desc': 'label: Renal interstitial necrotizing granulomas\ndefinition : An organized collection of histiocytes (specifically macrophages) localized in the interstitial tissue of the kidney. Through light microscopy, the activated histiocytes appear as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells. Granulomas may be associated with a peripheral cuff of lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined. Granulomas can present as necrotizing or non-necrotizing. Microscopically, necrotizing granulomas distinctly have central necrosis with a palisaded lymphohistiocytic reaction and a cuff of chronic inflammation.\nsynonyms :Renal interstitial necrotizing granulomata\n'}


{'id': 'HP_0032643', 'url': 'http://purl.obolibrary.org/obo/HP_0032643', 'lbl': 'Renal interstitial non-necrotizing granulomas', 'desc': 'label: Renal interstitial non-necrotizing granulomas\ndefinition : Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present with no necrosis.\nsynonyms :Renal interstitial non-necrotizing granulomata\n'}


{'id': 'HP_0032644', 'url': 'http://purl.obolibrary.org/obo/HP_0032644', 'lbl': 'Renal interstitial deposits', 'desc': 'label: Renal interstitial deposits\ndefinition : Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032645', 'url': 'http://purl.obolibrary.org/obo/HP_0032645', 'lbl': 'Renal interstitial mononuclear cell infiltration', 'desc': 'label: Renal interstitial mononuclear cell infiltration\ndefinition : Presence of interstitial mononuclear leukocytes, i.e., white blood ceclls with a single round nucleus, including lymphocytes and monocytes but not including granulocytes (which have multilobed nuclei).\nsynonyms :\n'}


{'id': 'HP_0032646', 'url': 'http://purl.obolibrary.org/obo/HP_0032646', 'lbl': 'Renal interstitial xanthogranulomatous inflammation', 'desc': 'label: Renal interstitial xanthogranulomatous inflammation\ndefinition : Inflammation of interstitial tissues of the kidney consisting of foamy macrophages admixed with plasma cells, lymphocytes and neutrophils and occasional giant cells.\nsynonyms :\n'}


{'id': 'HP_0032647', 'url': 'http://purl.obolibrary.org/obo/HP_0032647', 'lbl': 'Renal tubular epithelial cell apoptosis', 'desc': 'label: Renal tubular epithelial cell apoptosis\ndefinition : Increased apoptosis (programmed cell death) of tubular epithelial cells. The cells arre rounded with increased eosinophilia and contain fragmented, densely basophilic nuclear debris.\nsynonyms :\n'}


{'id': 'HP_0032648', 'url': 'http://purl.obolibrary.org/obo/HP_0032648', 'lbl': 'Tubularization of Bowman capsule', 'desc': 'label: Tubularization of Bowman capsule\ndefinition : The presence of cuboidal to columnar epithelium (height greater than width) lining the Bowman capsule, in an absence of adjacent segmental sclerosis, crescents, or collapsing variant of focal segmental glomerulosclerosis; scored as present or absent in at least one glomerulus.\nsynonyms :\n'}


{'id': 'HP_0032649', 'url': 'http://purl.obolibrary.org/obo/HP_0032649', 'lbl': 'Skewfoot', 'desc': 'label: Skewfoot\ndefinition : A type of flat-foot characterized by hindfoot abductovalgus, metatarsus adductus, and Achilles tendon shortening. The predominant radiographic findings include forefoot adduction with lateral subluxation of the navicular on the talus and heel valgus. Very abnormal shoe wear is noted on the medial side. Calluses occurunder the metatarsal heads and thehead of the plantar-flexed talus.\nsynonyms :Skew foot; Skew-foot\n'}


{'id': 'HP_0032650', 'url': 'http://purl.obolibrary.org/obo/HP_0032650', 'lbl': 'Elevated CSF glial fibrillary acidic protein concentration', 'desc': 'label: Elevated CSF glial fibrillary acidic protein concentration\ndefinition : Increased concentration of glial fibrillary acidic protein in cerebrospinal fluid.\nsynonyms :Elevated CSF glial fibrillary acidic protein level\n'}


{'id': 'HP_0032651', 'url': 'http://purl.obolibrary.org/obo/HP_0032651', 'lbl': 'Elevated CSF chitinase-3-like protein 1 concentration', 'desc': 'label: Elevated CSF chitinase-3-like protein 1 concentration\ndefinition : Increased concentration of chitinase-3-like protein 1 in cerebrospinal fluid.\nsynonyms :Elevated CSF chitinase-3-like protein 1 level\n'}


{'id': 'HP_0032652', 'url': 'http://purl.obolibrary.org/obo/HP_0032652', 'lbl': 'Elevated CSF chitotriosidase 1 concentration', 'desc': 'label: Elevated CSF chitotriosidase 1 concentration\ndefinition : Increased concentration of chitotriosidase 1 in cerebrospinal fluid.\nsynonyms :Elevated CSF chitotriosidase 1 level\n'}


{'id': 'HP_0032653', 'url': 'http://purl.obolibrary.org/obo/HP_0032653', 'lbl': 'Elevated lactate:pyruvate ratio', 'desc': 'label: Elevated lactate:pyruvate ratio\ndefinition : An abnormal increase in the molar ratio of lactate to pyruvate in the blood circulation.\nsynonyms :\n'}