{'id': 'HP_0006747', 'url': 'http://purl.obolibrary.org/obo/HP_0006747', 'lbl': 'Ganglioneuroblastoma', 'desc': 'label: Ganglioneuroblastoma\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006748', 'url': 'http://purl.obolibrary.org/obo/HP_0006748', 'lbl': 'Adrenal pheochromocytoma', 'desc': 'label: Adrenal pheochromocytoma\ndefinition : Pheochromocytoma originating from the adrenal medulla.\nsynonyms :Pheochromocytoma, adrenal; Pheochromocytomas, adrenal\n'}


{'id': 'HP_0006749', 'url': 'http://purl.obolibrary.org/obo/HP_0006749', 'lbl': 'Malignant gastrointestinal tract tumors', 'desc': 'label: Malignant gastrointestinal tract tumors\ndefinition : \nsynonyms :Malignant GI tract tumors; Malignant GI tract tumours; Malignant gastrointestinal tract tumours\n'}


{'id': 'HP_0006751', 'url': 'http://purl.obolibrary.org/obo/HP_0006751', 'lbl': 'Paraspinal neurofibroma', 'desc': 'label: Paraspinal neurofibroma\ndefinition : A neurofibroma (benign peripheral nerve sheath tumor) localized adjacent to the spine.\nsynonyms :Paraspinal neurofibromas\n'}


{'id': 'HP_0006753', 'url': 'http://purl.obolibrary.org/obo/HP_0006753', 'lbl': 'Neoplasm of the stomach', 'desc': 'label: Neoplasm of the stomach\ndefinition : A tumor (abnormal growth of tissue) of the stomach.\nsynonyms :Stomach tumor; Stomach tumour; Neoplasia of the stomach\n'}


{'id': 'HP_0006755', 'url': 'http://purl.obolibrary.org/obo/HP_0006755', 'lbl': 'Cutaneous leiomyosarcoma', 'desc': 'label: Cutaneous leiomyosarcoma\ndefinition : The presence of leiomyosarcoma of the skin.\nsynonyms :\n'}


{'id': 'HP_0006756', 'url': 'http://purl.obolibrary.org/obo/HP_0006756', 'lbl': 'Diffuse leiomyomatosis', 'desc': 'label: Diffuse leiomyomatosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006758', 'url': 'http://purl.obolibrary.org/obo/HP_0006758', 'lbl': 'Malignant genitourinary tract tumor', 'desc': 'label: Malignant genitourinary tract tumor\ndefinition : The presence of a malignant neoplasm of the genital system.\nsynonyms :Malignant GU tract tumor; Malignant GU tract tumour; Malignant genitourinary tract tumour\n'}


{'id': 'HP_0006762', 'url': 'http://purl.obolibrary.org/obo/HP_0006762', 'lbl': 'Renal pelvic carcinoma', 'desc': 'label: Renal pelvic carcinoma\ndefinition : The presence of a carcinoma in the renal pelvis.\nsynonyms :\n'}


{'id': 'HP_0006763', 'url': 'http://purl.obolibrary.org/obo/HP_0006763', 'lbl': 'Anal canal squamous carcinoma', 'desc': 'label: Anal canal squamous carcinoma\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006765', 'url': 'http://purl.obolibrary.org/obo/HP_0006765', 'lbl': 'Chondrosarcoma', 'desc': 'label: Chondrosarcoma\ndefinition : A slowly growing malignant neoplasm derived from cartilage cells.\nsynonyms :\n'}


{'id': 'HP_0006766', 'url': 'http://purl.obolibrary.org/obo/HP_0006766', 'lbl': 'Papillary renal cell carcinoma', 'desc': 'label: Papillary renal cell carcinoma\ndefinition : The presence of renal cell carcinoma in the renal papilla.\nsynonyms :\n'}


{'id': 'HP_0006767', 'url': 'http://purl.obolibrary.org/obo/HP_0006767', 'lbl': 'Pituitary prolactin cell adenoma', 'desc': 'label: Pituitary prolactin cell adenoma\ndefinition : A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women.\nsynonyms :Pituitary prolactinoma; Prolactin-secreting pituitary adenoma\n'}


{'id': 'HP_0006768', 'url': 'http://purl.obolibrary.org/obo/HP_0006768', 'lbl': 'Localized neuroblastoma', 'desc': 'label: Localized neuroblastoma\ndefinition : \nsynonyms :Localised neuroblastoma\n'}


{'id': 'HP_0006769', 'url': 'http://purl.obolibrary.org/obo/HP_0006769', 'lbl': 'Myxoid subcutaneous tumors', 'desc': 'label: Myxoid subcutaneous tumors\ndefinition : \nsynonyms :Myxoid subcutaneous tumours\n'}


{'id': 'HP_0006770', 'url': 'http://purl.obolibrary.org/obo/HP_0006770', 'lbl': 'Clear cell renal cell carcinoma', 'desc': 'label: Clear cell renal cell carcinoma\ndefinition : A subtype of renal cell carcinoma thought to originate from mature renal tubular cells in the proximal tubule of the nehpron.\nsynonyms :Nonpapillary renal cell carcinoma\n'}


{'id': 'HP_0006771', 'url': 'http://purl.obolibrary.org/obo/HP_0006771', 'lbl': 'Duodenal adenocarcinoma', 'desc': 'label: Duodenal adenocarcinoma\ndefinition : A malignant epithelial tumor with a glandular organization that originates in the duodenum.\nsynonyms :Duodenal cancer\n'}


{'id': 'HP_0006772', 'url': 'http://purl.obolibrary.org/obo/HP_0006772', 'lbl': 'Renal angiomyolipoma', 'desc': 'label: Renal angiomyolipoma\ndefinition : A benign renal neoplasm composed of fat, vascular, and smooth muscle elements.\nsynonyms :Angiomyolipoma; Kidney angiomyolipoma\n'}


{'id': 'HP_0006773', 'url': 'http://purl.obolibrary.org/obo/HP_0006773', 'lbl': 'Cutaneous angiolipomas', 'desc': 'label: Cutaneous angiolipomas\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006774', 'url': 'http://purl.obolibrary.org/obo/HP_0006774', 'lbl': 'Ovarian papillary adenocarcinoma', 'desc': 'label: Ovarian papillary adenocarcinoma\ndefinition : The presence of a papillary adenocarcinoma of the ovary.\nsynonyms :\n'}


{'id': 'HP_0006775', 'url': 'http://purl.obolibrary.org/obo/HP_0006775', 'lbl': 'Multiple myeloma', 'desc': "label: Multiple myeloma\ndefinition : A malignant plasma cell tumor growing within soft tissue or within the skeleton.\nsynonyms :Kahler's disease; Plasmocytoma\n"}


{'id': 'HP_0006778', 'url': 'http://purl.obolibrary.org/obo/HP_0006778', 'lbl': 'Benign genitourinary tract neoplasm', 'desc': 'label: Benign genitourinary tract neoplasm\ndefinition : A non-malignant neoplasm of the genitourinary system.\nsynonyms :Benign GU tract neoplasm; Benign genitourinary tract tumor; Benign genitourinary tract tumour\n'}


{'id': 'HP_0006779', 'url': 'http://purl.obolibrary.org/obo/HP_0006779', 'lbl': 'Alveolar rhabdomyosarcoma', 'desc': 'label: Alveolar rhabdomyosarcoma\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006780', 'url': 'http://purl.obolibrary.org/obo/HP_0006780', 'lbl': 'Parathyroid carcinoma', 'desc': 'label: Parathyroid carcinoma\ndefinition : A malignancy of the parathyroid glands. Parathyroid carcinoma usually secretes parathyroid hormone, leading to hyperparathyroidism.\nsynonyms :Parathyroid Cancer\n'}


{'id': 'HP_0006781', 'url': 'http://purl.obolibrary.org/obo/HP_0006781', 'lbl': 'Hurthle cell thyroid adenoma', 'desc': 'label: Hurthle cell thyroid adenoma\ndefinition : A kind of thyroid adenoma characterized by the presence of oxyphil cells.\nsynonyms :\n'}


{'id': 'HP_0006782', 'url': 'http://purl.obolibrary.org/obo/HP_0006782', 'lbl': 'Malignant eosinophil proliferation', 'desc': 'label: Malignant eosinophil proliferation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006783', 'url': 'http://purl.obolibrary.org/obo/HP_0006783', 'lbl': 'Posterior pharyngeal cleft', 'desc': 'label: Posterior pharyngeal cleft\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006784', 'url': 'http://purl.obolibrary.org/obo/HP_0006784', 'lbl': 'Paranasal sinus hypoplasia', 'desc': 'label: Paranasal sinus hypoplasia\ndefinition : Underdevelopment of the paranasal sinuses.\nsynonyms :Small paranasal sinus; Decreased size of paranasal sinus; Decreased volume of paranasal sinus; Underdevelopment of paranasal sinus; Decreased growth of paranasal sinus; Decreased pneumatization of paranasal sinus; Atelectasis of paranasal sinus; Hypotrophic paranasal sinus\n'}


{'id': 'HP_0006785', 'url': 'http://purl.obolibrary.org/obo/HP_0006785', 'lbl': 'Limb-girdle muscular dystrophy', 'desc': 'label: Limb-girdle muscular dystrophy\ndefinition : Muscular dystrophy affecting the muscles of the limb girdle (the hips and shoulders).\nsynonyms :limb girdle muscular dystrophy\n'}


{'id': 'HP_0006789', 'url': 'http://purl.obolibrary.org/obo/HP_0006789', 'lbl': 'Mitochondrial encephalopathy', 'desc': 'label: Mitochondrial encephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006790', 'url': 'http://purl.obolibrary.org/obo/HP_0006790', 'lbl': 'Cerebral cortex with spongiform changes', 'desc': 'label: Cerebral cortex with spongiform changes\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006794', 'url': 'http://purl.obolibrary.org/obo/HP_0006794', 'lbl': 'Loss of ability to walk in first decade', 'desc': 'label: Loss of ability to walk in first decade\ndefinition : \nsynonyms :Loss of ability to walk in first decade\n'}


{'id': 'HP_0006799', 'url': 'http://purl.obolibrary.org/obo/HP_0006799', 'lbl': 'Basal ganglia cysts', 'desc': 'label: Basal ganglia cysts\ndefinition : \nsynonyms :Cystic lesions in the basal ganglia\n'}


{'id': 'HP_0006801', 'url': 'http://purl.obolibrary.org/obo/HP_0006801', 'lbl': 'Hyperactive deep tendon reflexes', 'desc': 'label: Hyperactive deep tendon reflexes\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006802', 'url': 'http://purl.obolibrary.org/obo/HP_0006802', 'lbl': 'Abnormal anterior horn cell morphology', 'desc': 'label: Abnormal anterior horn cell morphology\ndefinition : Any anomaly of the anterior horn cell.\nsynonyms :Abnormality of the anterior horn cell; Abnormality of the anterior horn cells; Anomaly of the anterior horn cells; Anterior horn cell disease\n'}


{'id': 'HP_0006803', 'url': 'http://purl.obolibrary.org/obo/HP_0006803', 'lbl': 'Vivid hallucinations', 'desc': 'label: Vivid hallucinations\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006808', 'url': 'http://purl.obolibrary.org/obo/HP_0006808', 'lbl': 'Cerebral hypomyelination', 'desc': 'label: Cerebral hypomyelination\ndefinition : Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the white matter of the central nervous system.\nsynonyms :Hypomyelination of the brain\n'}


{'id': 'HP_0006812', 'url': 'http://purl.obolibrary.org/obo/HP_0006812', 'lbl': 'White mater abnormalities in the posterior periventricular region', 'desc': 'label: White mater abnormalities in the posterior periventricular region\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006813', 'url': 'http://purl.obolibrary.org/obo/HP_0006813', 'lbl': 'Focal hemiclonic seizure', 'desc': 'label: Focal hemiclonic seizure\ndefinition : A type of focal clonic seizure characterized by sustained rhythmic jerking rapidly involves one side of the body at seizure onset.\nsynonyms :Hemiclonic seizure; Hemiclonic seizures; Unilateral clonic seizure; Unilateral clonic seizures\n'}


{'id': 'HP_0006817', 'url': 'http://purl.obolibrary.org/obo/HP_0006817', 'lbl': 'Aplasia/Hypoplasia of the cerebellar vermis', 'desc': 'label: Aplasia/Hypoplasia of the cerebellar vermis\ndefinition : Absence or underdevelopment of the vermis of cerebellum.\nsynonyms :Cerebellar vermis aplasia/hypoplasia; Hypo/aplastic vermis; Cerebellar vermis aplasia or hypoplasia\n'}


{'id': 'HP_0006818', 'url': 'http://purl.obolibrary.org/obo/HP_0006818', 'lbl': '4-layered lissencephaly', 'desc': 'label: 4-layered lissencephaly\ndefinition : A form of lissencephaly in which the cortex is thickened and has four more or less disorganized layers rather than six normal layers resulting from incomplete neuronal migration during brain development. At neuropathological examination, a 4-layered cortex consists of an upper molecular layer, a second thin cellular layer containing pyramidal neurons usually observed in layer V, a third pale poorly cellular layer and a fourth thick deep layer made up of neurons which had failed to migrate. Radiologocally would manifest as agyria or pachygyria with cortical thickness greater than 10 mm.\nsynonyms :Classic lissencephaly; Four-layered lissencephaly; Lissencephaly, type I; Type 1 lissencephaly; Type I lissencephaly\n'}


{'id': 'HP_0006821', 'url': 'http://purl.obolibrary.org/obo/HP_0006821', 'lbl': 'Frontal polymicrogyria', 'desc': 'label: Frontal polymicrogyria\ndefinition : A type of polymicrogyria with a gradient of severity (anterior more severe than posterior) extending from frontal poles posteriorly to precentral gyrus and inferiorly to frontal operculum.\nsynonyms :Polymicrogyria, anterior to posterior gradient\n'}


{'id': 'HP_0006824', 'url': 'http://purl.obolibrary.org/obo/HP_0006824', 'lbl': 'Cranial nerve paralysis', 'desc': 'label: Cranial nerve paralysis\ndefinition : \nsynonyms :Cranial nerve palsies; Cranial nerve palsy; Cranial nerve paresis\n'}


{'id': 'HP_0006825', 'url': 'http://purl.obolibrary.org/obo/HP_0006825', 'lbl': 'Pallor of dorsal columns of the spinal cord', 'desc': 'label: Pallor of dorsal columns of the spinal cord\ndefinition : An abnormally pale appearance of the dorsal portion of the gray substance of the spinal cord. This finding can be observed by histological examination.\nsynonyms :\n'}


{'id': 'HP_0006827', 'url': 'http://purl.obolibrary.org/obo/HP_0006827', 'lbl': 'Atrophy of the spinal cord', 'desc': 'label: Atrophy of the spinal cord\ndefinition : \nsynonyms :Degeneration of the spinal cord\n'}


{'id': 'HP_0006829', 'url': 'http://purl.obolibrary.org/obo/HP_0006829', 'lbl': 'Severe muscular hypotonia', 'desc': 'label: Severe muscular hypotonia\ndefinition : A severe degree of muscular hypotonia characterized by markedly reduced muscle tone.\nsynonyms :Hypotonia, severe; Severely decreased muscle tone\n'}


{'id': 'HP_0006830', 'url': 'http://purl.obolibrary.org/obo/HP_0006830', 'lbl': 'obsolete Severe neonatal hypotonia in males', 'desc': 'label: obsolete Severe neonatal hypotonia in males\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006834', 'url': 'http://purl.obolibrary.org/obo/HP_0006834', 'lbl': 'Developmental stagnation at onset of seizures', 'desc': 'label: Developmental stagnation at onset of seizures\ndefinition : A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills, following the onset of epilepsy.\nsynonyms :\n'}


{'id': 'HP_0006837', 'url': 'http://purl.obolibrary.org/obo/HP_0006837', 'lbl': 'Congenital Horner syndrome', 'desc': 'label: Congenital Horner syndrome\ndefinition : A type of Horner syndrome with congenital onset.\nsynonyms :\n'}


{'id': 'HP_0006844', 'url': 'http://purl.obolibrary.org/obo/HP_0006844', 'lbl': 'Absent patellar reflexes', 'desc': 'label: Absent patellar reflexes\ndefinition : Absence of the knee jerk reflex, which can normally be elicited by tapping the patellar tendon with a reflex hammer just below the patella.\nsynonyms :Absent knee jerk reflex\n'}


{'id': 'HP_0006846', 'url': 'http://purl.obolibrary.org/obo/HP_0006846', 'lbl': 'Acute encephalopathy', 'desc': 'label: Acute encephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006849', 'url': 'http://purl.obolibrary.org/obo/HP_0006849', 'lbl': 'Hypodysplasia of the corpus callosum', 'desc': 'label: Hypodysplasia of the corpus callosum\ndefinition : Developmental defect characterized by a small and malformed corpus callosum.\nsynonyms :\n'}


{'id': 'HP_0006850', 'url': 'http://purl.obolibrary.org/obo/HP_0006850', 'lbl': 'Hypoplasia of the ventral pons', 'desc': 'label: Hypoplasia of the ventral pons\ndefinition : Underdevelopment of the ventral portion of the pons.\nsynonyms :Underdeveloped ventral pons\n'}


{'id': 'HP_0006851', 'url': 'http://purl.obolibrary.org/obo/HP_0006851', 'lbl': 'Symmetric spinal nerve root neurofibromas', 'desc': 'label: Symmetric spinal nerve root neurofibromas\ndefinition : Multiple neurofibromas of the spinal nerve roots with a symmetric distribution.\nsynonyms :Spinal nerve root neurofibromas, symmetric, multiple\n'}


{'id': 'HP_0006852', 'url': 'http://purl.obolibrary.org/obo/HP_0006852', 'lbl': 'Episodic generalized hypotonia', 'desc': 'label: Episodic generalized hypotonia\ndefinition : The occurrence of repeated episodes of generalized muscular hypotonia.\nsynonyms :Episodic generalised hypotonia\n'}


{'id': 'HP_0006855', 'url': 'http://purl.obolibrary.org/obo/HP_0006855', 'lbl': 'Cerebellar vermis atrophy', 'desc': 'label: Cerebellar vermis atrophy\ndefinition : Wasting (atrophy) of the vermis of cerebellum.\nsynonyms :Atrophy of cerebellar vermis; Atrophy of the cerebellar vermis; Vermian atrophy\n'}


{'id': 'HP_0006858', 'url': 'http://purl.obolibrary.org/obo/HP_0006858', 'lbl': 'Impaired distal proprioception', 'desc': 'label: Impaired distal proprioception\ndefinition : A loss or impairment of the sensation of the relative position of parts of the body and joint position occuring at distal joints.\nsynonyms :Distal sensory loss of proprioception\n'}


{'id': 'HP_0006859', 'url': 'http://purl.obolibrary.org/obo/HP_0006859', 'lbl': 'Posterior leukoencephalopathy', 'desc': 'label: Posterior leukoencephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006863', 'url': 'http://purl.obolibrary.org/obo/HP_0006863', 'lbl': 'Severe expressive language delay', 'desc': 'label: Severe expressive language delay\ndefinition : A severe delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.\nsynonyms :\n'}


{'id': 'HP_0006865', 'url': 'http://purl.obolibrary.org/obo/HP_0006865', 'lbl': 'Sensorimotor polyneuropathy affecting arms more than legs', 'desc': 'label: Sensorimotor polyneuropathy affecting arms more than legs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006866', 'url': 'http://purl.obolibrary.org/obo/HP_0006866', 'lbl': 'Midline central nervous system lipomas', 'desc': 'label: Midline central nervous system lipomas\ndefinition : \nsynonyms :Midline CNS lipomas\n'}


{'id': 'HP_0006870', 'url': 'http://purl.obolibrary.org/obo/HP_0006870', 'lbl': 'Lobar holoprosencephaly', 'desc': 'label: Lobar holoprosencephaly\ndefinition : A type of holoprosencephaly in which most of the right and left cerebral hemispheres and lateral ventricles are separated but the most rostral aspect of the telencephalon, the frontal lobes, are fused, especially ventrally.\nsynonyms :\n'}


{'id': 'HP_0006872', 'url': 'http://purl.obolibrary.org/obo/HP_0006872', 'lbl': 'Cerebral hypoplasia', 'desc': 'label: Cerebral hypoplasia\ndefinition : Underdevelopment of the cerebrum.\nsynonyms :Small cerebrum; Underdeveloped cerebrum\n'}


{'id': 'HP_0006873', 'url': 'http://purl.obolibrary.org/obo/HP_0006873', 'lbl': 'Symmetrical progressive peripheral demyelination', 'desc': 'label: Symmetrical progressive peripheral demyelination\ndefinition : A symmetric and progressive loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.\nsynonyms :\n'}


{'id': 'HP_0006877', 'url': 'http://purl.obolibrary.org/obo/HP_0006877', 'lbl': 'obsolete Mental retardation, in some', 'desc': 'label: obsolete Mental retardation, in some\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006879', 'url': 'http://purl.obolibrary.org/obo/HP_0006879', 'lbl': 'Pontocerebellar atrophy', 'desc': 'label: Pontocerebellar atrophy\ndefinition : Atrophy affecting the pons and the cerebellum.\nsynonyms :Cerebellopontine atrophy\n'}


{'id': 'HP_0006880', 'url': 'http://purl.obolibrary.org/obo/HP_0006880', 'lbl': 'Cerebellar hemangioblastoma', 'desc': 'label: Cerebellar hemangioblastoma\ndefinition : A hemangioblastoma of the cerebellum.\nsynonyms :Hemangioblastoma, sporadic cerebellar\n'}


{'id': 'HP_0006881', 'url': 'http://purl.obolibrary.org/obo/HP_0006881', 'lbl': 'Diffuse peripheral demyelination', 'desc': 'label: Diffuse peripheral demyelination\ndefinition : A diffuse loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.\nsynonyms :\n'}


{'id': 'HP_0006882', 'url': 'http://purl.obolibrary.org/obo/HP_0006882', 'lbl': 'Severe hydrocephalus', 'desc': 'label: Severe hydrocephalus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006886', 'url': 'http://purl.obolibrary.org/obo/HP_0006886', 'lbl': 'Impaired distal vibration sensation', 'desc': 'label: Impaired distal vibration sensation\ndefinition : A decrease in the ability to perceive vibration in the distal portions of the limbs.\nsynonyms :Decreased distal vibration sense\n'}


{'id': 'HP_0006887', 'url': 'http://purl.obolibrary.org/obo/HP_0006887', 'lbl': 'Intellectual disability, progressive', 'desc': 'label: Intellectual disability, progressive\ndefinition : The term progressive intellectual disability should be used if intelligence decreases/deteriorates over time.\nsynonyms :Intellectual disability, progressive; Mental retardation, progressive; Progressive mental retardation\n'}


{'id': 'HP_0006888', 'url': 'http://purl.obolibrary.org/obo/HP_0006888', 'lbl': 'Meningoencephalocele', 'desc': 'label: Meningoencephalocele\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006889', 'url': 'http://purl.obolibrary.org/obo/HP_0006889', 'lbl': 'Intellectual disability, borderline', 'desc': 'label: Intellectual disability, borderline\ndefinition : Borderline intellectual disability is defined as an intelligence quotient (IQ) in the range of 70-85.\nsynonyms :Intellectual disability, borderline; Mental retardation, borderline\n'}


{'id': 'HP_0006891', 'url': 'http://purl.obolibrary.org/obo/HP_0006891', 'lbl': 'Thick cerebral cortex', 'desc': 'label: Thick cerebral cortex\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006892', 'url': 'http://purl.obolibrary.org/obo/HP_0006892', 'lbl': 'Frontotemporal cerebral atrophy', 'desc': 'label: Frontotemporal cerebral atrophy\ndefinition : Atrophy (wasting, decrease in size of cells or tissue) affecting the frontotemporal cerebrum.\nsynonyms :Cerebral atrophy, frontotemporal\n'}


{'id': 'HP_0006893', 'url': 'http://purl.obolibrary.org/obo/HP_0006893', 'lbl': 'obsolete Severely dysplastic cerebellum', 'desc': 'label: obsolete Severely dysplastic cerebellum\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006894', 'url': 'http://purl.obolibrary.org/obo/HP_0006894', 'lbl': 'Hypoplastic olfactory lobes', 'desc': 'label: Hypoplastic olfactory lobes\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006895', 'url': 'http://purl.obolibrary.org/obo/HP_0006895', 'lbl': 'Lower limb hypertonia', 'desc': 'label: Lower limb hypertonia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006896', 'url': 'http://purl.obolibrary.org/obo/HP_0006896', 'lbl': 'Hypnopompic hallucinations', 'desc': 'label: Hypnopompic hallucinations\ndefinition : Fleeting perceptual experiences that occur during the transition from sleep to wakefulness.\nsynonyms :\n'}


{'id': 'HP_0006897', 'url': 'http://purl.obolibrary.org/obo/HP_0006897', 'lbl': 'Abducens palsy', 'desc': 'label: Abducens palsy\ndefinition : Malfunction of the abducens nerve as manifested by impairment of the ability of the affected eye to be moved outward. Patients who develop abducens nerve palsy often present with binocular horizontal diplopia, which is a double vision when looking at objects side by side. There will be a notable weakness of the ipsilateral lateral rectus muscle leading to a deficit in of eye abduction on the affected side. Some patients may present with a constant head turning movement to maintain binocular fusion and to lessen the degree of diplopia.\nsynonyms :Abducens nerve palsy; Abducens nerve paralysis; Abducens nerve paresis; Cranial nerve VI palsy; Lateral rectus muscle denervation paresis; Sixth nerve palsy\n'}


{'id': 'HP_0006899', 'url': 'http://purl.obolibrary.org/obo/HP_0006899', 'lbl': 'Fusion of the cerebellar hemispheres', 'desc': 'label: Fusion of the cerebellar hemispheres\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006901', 'url': 'http://purl.obolibrary.org/obo/HP_0006901', 'lbl': 'obsolete Impaired thermal sensitivity', 'desc': 'label: obsolete Impaired thermal sensitivity\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006903', 'url': 'http://purl.obolibrary.org/obo/HP_0006903', 'lbl': 'Congenital peripheral neuropathy', 'desc': 'label: Congenital peripheral neuropathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006904', 'url': 'http://purl.obolibrary.org/obo/HP_0006904', 'lbl': 'Late-onset spinocerebellar degeneration', 'desc': 'label: Late-onset spinocerebellar degeneration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006906', 'url': 'http://purl.obolibrary.org/obo/HP_0006906', 'lbl': 'Congenital intracerebral calcification', 'desc': 'label: Congenital intracerebral calcification\ndefinition : The presence of calcium deposition within brain structures that is present already at the time of birth.\nsynonyms :\n'}


{'id': 'HP_0006913', 'url': 'http://purl.obolibrary.org/obo/HP_0006913', 'lbl': 'Frontal cortical atrophy', 'desc': 'label: Frontal cortical atrophy\ndefinition : Atrophy of the frontal cortex.\nsynonyms :Frontal cortex degeneration\n'}


{'id': 'HP_0006915', 'url': 'http://purl.obolibrary.org/obo/HP_0006915', 'lbl': 'Inability to walk by childhood/adolescence', 'desc': 'label: Inability to walk by childhood/adolescence\ndefinition : \nsynonyms :Inability to walk by childhood/adolescence\n'}


{'id': 'HP_0006916', 'url': 'http://purl.obolibrary.org/obo/HP_0006916', 'lbl': 'Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material', 'desc': 'label: Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material\ndefinition : Curvilinear intracellular accumulation of autofluorescent lipopigment storage material within axons.\nsynonyms :Intraaxonal accumulation of curvilinear profiles\n'}


{'id': 'HP_0006918', 'url': 'http://purl.obolibrary.org/obo/HP_0006918', 'lbl': 'Diffuse cerebral sclerosis', 'desc': 'label: Diffuse cerebral sclerosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006919', 'url': 'http://purl.obolibrary.org/obo/HP_0006919', 'lbl': 'Abnormal aggressive, impulsive or violent behavior', 'desc': 'label: Abnormal aggressive, impulsive or violent behavior\ndefinition : \nsynonyms :Aggressive/violent behavior; Aggressive/violent behaviour; Abnormal aggressive, impulsive or violent behaviour\n'}


{'id': 'HP_0006921', 'url': 'http://purl.obolibrary.org/obo/HP_0006921', 'lbl': 'Axial muscle stiffness', 'desc': 'label: Axial muscle stiffness\ndefinition : Stiffness (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) of the axial musculature.\nsynonyms :\n'}


{'id': 'HP_0006926', 'url': 'http://purl.obolibrary.org/obo/HP_0006926', 'lbl': 'Metachromatic leukodystrophy variant', 'desc': 'label: Metachromatic leukodystrophy variant\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006927', 'url': 'http://purl.obolibrary.org/obo/HP_0006927', 'lbl': 'Unilateral polymicrogyria', 'desc': 'label: Unilateral polymicrogyria\ndefinition : Excessive number of small gyri (convolutions) on the surface of one side of the brain.\nsynonyms :\n'}


{'id': 'HP_0006929', 'url': 'http://purl.obolibrary.org/obo/HP_0006929', 'lbl': 'Hypoglycemic encephalopathy', 'desc': 'label: Hypoglycemic encephalopathy\ndefinition : Brain damage related to a lowering of blood glucose below a critical level (around 30 mg/dl), which may lead to confusion, lethargy and delirium followed by seizures and coma. Prolonged hypoglycemia may lead to irreversible brain damage.\nsynonyms :\n'}


{'id': 'HP_0006930', 'url': 'http://purl.obolibrary.org/obo/HP_0006930', 'lbl': 'Frontoparietal cortical dysplasia', 'desc': 'label: Frontoparietal cortical dysplasia\ndefinition : The presence of developmental dysplasia of the cortex of frontal lobe and the cortex of parietal lobe.\nsynonyms :\n'}


{'id': 'HP_0006931', 'url': 'http://purl.obolibrary.org/obo/HP_0006931', 'lbl': 'Pericallosal lipoma', 'desc': 'label: Pericallosal lipoma\ndefinition : Pericallosal lipomas are congenital soft masses of adipose cells encapsulated by a thin layer of fibrous tissue, appearing adjacent to the corpus callosum of the brain.\nsynonyms :Lipoma of corpus callosum\n'}


{'id': 'HP_0006932', 'url': 'http://purl.obolibrary.org/obo/HP_0006932', 'lbl': 'Transient psychotic episodes', 'desc': 'label: Transient psychotic episodes\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006934', 'url': 'http://purl.obolibrary.org/obo/HP_0006934', 'lbl': 'Congenital nystagmus', 'desc': 'label: Congenital nystagmus\ndefinition : Nystagmus dating from or present at birth.\nsynonyms :Nystagmus, congenital\n'}


{'id': 'HP_0006937', 'url': 'http://purl.obolibrary.org/obo/HP_0006937', 'lbl': 'Impaired distal tactile sensation', 'desc': "label: Impaired distal tactile sensation\ndefinition : A reduced sense of touch (tactile sensation) on the skin of the distal limbs. This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus.\nsynonyms :Decreased distal touch sense; Decreased touch sensation in extremities\n"}


{'id': 'HP_0006938', 'url': 'http://purl.obolibrary.org/obo/HP_0006938', 'lbl': 'Impaired vibration sensation at ankles', 'desc': 'label: Impaired vibration sensation at ankles\ndefinition : A decrease in the ability to perceive vibration at the ankles. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to the malleoli of the ankles.\nsynonyms :Decreased vibration sense at ankles; Decreased vibration sense in feet; Impaired vibration sensation at ankles\n'}


{'id': 'HP_0006943', 'url': 'http://purl.obolibrary.org/obo/HP_0006943', 'lbl': 'Diffuse spongiform leukoencephalopathy', 'desc': 'label: Diffuse spongiform leukoencephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006944', 'url': 'http://purl.obolibrary.org/obo/HP_0006944', 'lbl': 'Abolished vibration sense', 'desc': 'label: Abolished vibration sense\ndefinition : A complete loss of the ability to perceive vibration.\nsynonyms :Apallesthesia\n'}


{'id': 'HP_0006946', 'url': 'http://purl.obolibrary.org/obo/HP_0006946', 'lbl': 'Recurrent meningitis', 'desc': 'label: Recurrent meningitis\ndefinition : An increased susceptibility to meningitis as manifested by a medical history of recurrent episodes of meningitis.\nsynonyms :\n'}


{'id': 'HP_0006949', 'url': 'http://purl.obolibrary.org/obo/HP_0006949', 'lbl': 'Episodic peripheral neuropathy', 'desc': 'label: Episodic peripheral neuropathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006951', 'url': 'http://purl.obolibrary.org/obo/HP_0006951', 'lbl': 'Retrocerebellar cyst', 'desc': 'label: Retrocerebellar cyst\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006955', 'url': 'http://purl.obolibrary.org/obo/HP_0006955', 'lbl': 'Olivopontocerebellar hypoplasia', 'desc': 'label: Olivopontocerebellar hypoplasia\ndefinition : Hypoplasia of the cerebellum, pontine nuclei, and inferior olivary nucleus.\nsynonyms :\n'}


{'id': 'HP_0006956', 'url': 'http://purl.obolibrary.org/obo/HP_0006956', 'lbl': 'Lateral ventricle dilatation', 'desc': 'label: Lateral ventricle dilatation\ndefinition : \nsynonyms :Dilatation of lateral cerebral ventricles; Dilation of lateral ventricles; Enlarged lateral ventricles; Lateral ventricle dilatation\n'}


{'id': 'HP_0006957', 'url': 'http://purl.obolibrary.org/obo/HP_0006957', 'lbl': 'obsolete Loss of ability to walk', 'desc': 'label: obsolete Loss of ability to walk\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006958', 'url': 'http://purl.obolibrary.org/obo/HP_0006958', 'lbl': 'Abnormal auditory evoked potentials', 'desc': 'label: Abnormal auditory evoked potentials\ndefinition : An abnormality of the auditory evoked potentials, which are used to trace the signal generated by a sound, from the cochlear nerve, through the lateral lemniscus, to the medial geniculate nucleus, and to the cortex.\nsynonyms :Abnormal brainstem auditory-evoked potentials\n'}


{'id': 'HP_0006959', 'url': 'http://purl.obolibrary.org/obo/HP_0006959', 'lbl': 'Proximal spinal muscular atrophy', 'desc': 'label: Proximal spinal muscular atrophy\ndefinition : Proximal spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem.\nsynonyms :\n'}


{'id': 'HP_0006960', 'url': 'http://purl.obolibrary.org/obo/HP_0006960', 'lbl': 'Choroid plexus calcification', 'desc': 'label: Choroid plexus calcification\ndefinition : The presence of calcium deposition in the choroid plexus.\nsynonyms :Calcified choroid plexus\n'}


{'id': 'HP_0006961', 'url': 'http://purl.obolibrary.org/obo/HP_0006961', 'lbl': 'Jerky head movements', 'desc': 'label: Jerky head movements\ndefinition : \nsynonyms :Head jerking; Jerking head movements\n'}


{'id': 'HP_0006962', 'url': 'http://purl.obolibrary.org/obo/HP_0006962', 'lbl': 'Gait instability, worse in the dark', 'desc': 'label: Gait instability, worse in the dark\ndefinition : \nsynonyms :Unstable walking, worse in the dark\n'}


{'id': 'HP_0006964', 'url': 'http://purl.obolibrary.org/obo/HP_0006964', 'lbl': 'Cerebral cortical neurodegeneration', 'desc': 'label: Cerebral cortical neurodegeneration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006965', 'url': 'http://purl.obolibrary.org/obo/HP_0006965', 'lbl': 'Acute necrotizing encephalopathy', 'desc': 'label: Acute necrotizing encephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006970', 'url': 'http://purl.obolibrary.org/obo/HP_0006970', 'lbl': 'Periventricular leukomalacia', 'desc': 'label: Periventricular leukomalacia\ndefinition : Periventricular leukomalacia is characterized by diffuse injury of deep cerebral white matter, accompanied in its most severe form by focal necrosis. The neuropathologic hallmarks of PVL are microglial activation and focal and diffuse periventricular depletion of premyelinating oligodendroglia.\nsynonyms :PVL\n'}


{'id': 'HP_0006976', 'url': 'http://purl.obolibrary.org/obo/HP_0006976', 'lbl': 'Necrotizing encephalopathy', 'desc': 'label: Necrotizing encephalopathy\ndefinition : A type of encephalopathy (brain disease, damage, or malfunction accompanied by an altered mental state) that is characterized by evidence of necrosis of brain tissue.\nsynonyms :\n'}


{'id': 'HP_0006977', 'url': 'http://purl.obolibrary.org/obo/HP_0006977', 'lbl': 'Deficit in grammar', 'desc': 'label: Deficit in grammar\ndefinition : Deficit in grammar, including syntax and morphology.\nsynonyms :Grammar-specific speech disorder\n'}


{'id': 'HP_0006978', 'url': 'http://purl.obolibrary.org/obo/HP_0006978', 'lbl': 'Dysmyelinating leukodystrophy', 'desc': 'label: Dysmyelinating leukodystrophy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006979', 'url': 'http://purl.obolibrary.org/obo/HP_0006979', 'lbl': 'Sleep-wake cycle disturbance', 'desc': "label: Sleep-wake cycle disturbance\ndefinition : Any abnormal alteration of an individual's circadian rhythm that affects the timing of sleeping and being awake.\nsynonyms :Sleep-wake cycle disturbance\n"}


{'id': 'HP_0006980', 'url': 'http://purl.obolibrary.org/obo/HP_0006980', 'lbl': 'Progressive leukoencephalopathy', 'desc': 'label: Progressive leukoencephalopathy\ndefinition : Leukoencephalopathy that gets more severe with time.\nsynonyms :Leukoencephalopathy, progressive\n'}


{'id': 'HP_0006983', 'url': 'http://purl.obolibrary.org/obo/HP_0006983', 'lbl': 'obsolete Slowly progressive spastic quadriparesis', 'desc': 'label: obsolete Slowly progressive spastic quadriparesis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006984', 'url': 'http://purl.obolibrary.org/obo/HP_0006984', 'lbl': 'obsolete Distal sensory loss of all modalities', 'desc': 'label: obsolete Distal sensory loss of all modalities\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006986', 'url': 'http://purl.obolibrary.org/obo/HP_0006986', 'lbl': 'Upper limb spasticity', 'desc': 'label: Upper limb spasticity\ndefinition : \nsynonyms :Uncontrollable movement in upper arms\n'}


{'id': 'HP_0006988', 'url': 'http://purl.obolibrary.org/obo/HP_0006988', 'lbl': 'Alobar holoprosencephaly', 'desc': 'label: Alobar holoprosencephaly\ndefinition : A type of holoprosencephaly characterized by the presence of a single ventricle and no separation of the cerebral hemisphere. The single midline ventricle is often greatly enlarged.\nsynonyms :\n'}


{'id': 'HP_0006989', 'url': 'http://purl.obolibrary.org/obo/HP_0006989', 'lbl': 'Dysplastic corpus callosum', 'desc': 'label: Dysplastic corpus callosum\ndefinition : Dysplasia and dysgenesis of the corpus callosum are nonspecific descriptions that imply defective development of the corpus callosum. The term dysplasia is applied when the morphology of the corpus callosum is altered as a congenital trait. For instance, the corpus callosum may be hump-shaped, kinked, or a striped corpus callosum that lacks an anatomically distinct genu and splenium.\nsynonyms :Dysgenesis of corpus callosum; Dysplasia of corpus callosum\n'}


{'id': 'HP_0006990', 'url': 'http://purl.obolibrary.org/obo/HP_0006990', 'lbl': 'Myelin-dependent gliosis', 'desc': 'label: Myelin-dependent gliosis\ndefinition : A type of gliosis that occurs in the vicinity of injured neurons.\nsynonyms :\n'}


{'id': 'HP_0006992', 'url': 'http://purl.obolibrary.org/obo/HP_0006992', 'lbl': 'Anterior basal encephalocele', 'desc': 'label: Anterior basal encephalocele\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006994', 'url': 'http://purl.obolibrary.org/obo/HP_0006994', 'lbl': 'Diffuse leukoencephalopathy', 'desc': 'label: Diffuse leukoencephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0006999', 'url': 'http://purl.obolibrary.org/obo/HP_0006999', 'lbl': 'Basal ganglia gliosis', 'desc': 'label: Basal ganglia gliosis\ndefinition : Focal proliferation of glial cells in the basal ganglia.\nsynonyms :Gliosis in the basal ganglia\n'}


{'id': 'HP_0007000', 'url': 'http://purl.obolibrary.org/obo/HP_0007000', 'lbl': 'Morning myoclonic jerks', 'desc': 'label: Morning myoclonic jerks\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007001', 'url': 'http://purl.obolibrary.org/obo/HP_0007001', 'lbl': 'Loss of Purkinje cells in the cerebellar vermis', 'desc': 'label: Loss of Purkinje cells in the cerebellar vermis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007002', 'url': 'http://purl.obolibrary.org/obo/HP_0007002', 'lbl': 'Motor axonal neuropathy', 'desc': 'label: Motor axonal neuropathy\ndefinition : Progressive impairment of function of motor axons with muscle weakness, atrophy, and cramps. The deficits are length-dependent, meaning that muscles innervated by the longest nerves are affected first, so that for instance the arms are affected at a later age than the onset of deficits involving the lower leg.\nsynonyms :Distal motor neuropathy; Length dependent motor neuropathy\n'}


{'id': 'HP_0007006', 'url': 'http://purl.obolibrary.org/obo/HP_0007006', 'lbl': 'Dorsal column degeneration', 'desc': 'label: Dorsal column degeneration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007007', 'url': 'http://purl.obolibrary.org/obo/HP_0007007', 'lbl': 'Cavitation of the basal ganglia', 'desc': 'label: Cavitation of the basal ganglia\ndefinition : The formation of small cavities in the tissue of the basal ganglia.\nsynonyms :\n'}


{'id': 'HP_0007009', 'url': 'http://purl.obolibrary.org/obo/HP_0007009', 'lbl': 'Central nervous system degeneration', 'desc': 'label: Central nervous system degeneration\ndefinition : \nsynonyms :CNS degeneration\n'}


{'id': 'HP_0007010', 'url': 'http://purl.obolibrary.org/obo/HP_0007010', 'lbl': 'Poor fine motor coordination', 'desc': 'label: Poor fine motor coordination\ndefinition : An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes.\nsynonyms :Fine motor disability; Fine motor impairment; Fine motor skill dysfunction; Impaired fine motor skills\n'}


{'id': 'HP_0007011', 'url': 'http://purl.obolibrary.org/obo/HP_0007011', 'lbl': 'Fourth cranial nerve palsy', 'desc': 'label: Fourth cranial nerve palsy\ndefinition : Paralysis of the fourth cranial (trochlear) nerve manifested as weakness of the superior oblique muscle which causes vertical diplopia that is maximal when the affected eye is adducted and directed inferiorly.\nsynonyms :Trochlear nerve palsy\n'}


{'id': 'HP_0007015', 'url': 'http://purl.obolibrary.org/obo/HP_0007015', 'lbl': 'Poor gross motor coordination', 'desc': 'label: Poor gross motor coordination\ndefinition : An abnormality of the ability (skills) to perform a precise movement of large muscles with the intent to perform a specific act. Gross motor skills are required to mediate movements of the arms, legs, and other large body parts.\nsynonyms :Gross motor impairment\n'}


{'id': 'HP_0007016', 'url': 'http://purl.obolibrary.org/obo/HP_0007016', 'lbl': 'Corticospinal tract hypoplasia', 'desc': 'label: Corticospinal tract hypoplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007017', 'url': 'http://purl.obolibrary.org/obo/HP_0007017', 'lbl': 'Progressive forgetfulness', 'desc': 'label: Progressive forgetfulness\ndefinition : \nsynonyms :Forgetfullness\n'}


{'id': 'HP_0007018', 'url': 'http://purl.obolibrary.org/obo/HP_0007018', 'lbl': 'Attention deficit hyperactivity disorder', 'desc': 'label: Attention deficit hyperactivity disorder\ndefinition : Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient.\nsynonyms :ADHD; Attention deficit; Attention deficit disorder; Attention deficit-hyperactivity disorder; Attention deficits; Childhood attention deficit/hyperactivity disorder\n'}


{'id': 'HP_0007020', 'url': 'http://purl.obolibrary.org/obo/HP_0007020', 'lbl': 'Progressive spastic paraplegia', 'desc': 'label: Progressive spastic paraplegia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007021', 'url': 'http://purl.obolibrary.org/obo/HP_0007021', 'lbl': 'Pain insensitivity', 'desc': 'label: Pain insensitivity\ndefinition : Inability to perceive painful stimuli.\nsynonyms :Absence of pain sensation\n'}


{'id': 'HP_0007023', 'url': 'http://purl.obolibrary.org/obo/HP_0007023', 'lbl': 'Antenatal intracerebral hemorrhage', 'desc': 'label: Antenatal intracerebral hemorrhage\ndefinition : Cerebral hemorrhage that occurs before birth.\nsynonyms :Antenatal intracerebral haemorrhage\n'}


{'id': 'HP_0007024', 'url': 'http://purl.obolibrary.org/obo/HP_0007024', 'lbl': 'Pseudobulbar paralysis', 'desc': 'label: Pseudobulbar paralysis\ndefinition : Bilateral impairment of the function of the cranial nerves 9-12, which control musculature involved in eating, swallowing, and speech. Pseudobulbar paralysis is characterized clinically by dysarthria, dysphonia, and dysphagia with bifacial paralysis, and may be accompanied by Pseudobulbar behavioral symptoms such as enforced crying and laughing.\nsynonyms :Pseudobulbar palsy; Pseudobulbar syndrome\n'}


{'id': 'HP_0007027', 'url': 'http://purl.obolibrary.org/obo/HP_0007027', 'lbl': 'Poorly formed metencephalon', 'desc': 'label: Poorly formed metencephalon\ndefinition : A morphological abnormality of the metencephalon.\nsynonyms :\n'}


{'id': 'HP_0007029', 'url': 'http://purl.obolibrary.org/obo/HP_0007029', 'lbl': 'Cerebral berry aneurysm', 'desc': 'label: Cerebral berry aneurysm\ndefinition : A small, sac-like aneurysm (outpouching) of a cerebral blood vessel.\nsynonyms :Cerebral saccular aneurysm\n'}


{'id': 'HP_0007030', 'url': 'http://purl.obolibrary.org/obo/HP_0007030', 'lbl': 'Nonprogressive encephalopathy', 'desc': 'label: Nonprogressive encephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007033', 'url': 'http://purl.obolibrary.org/obo/HP_0007033', 'lbl': 'Cerebellar dysplasia', 'desc': 'label: Cerebellar dysplasia\ndefinition : Cerebellar dysplasia (abnormal growth or development) is defined by abnormal cerebellar foliation, white matter arborization, and gray-white matter junction. Cerebellar dysplasia is a neuroimaging finding that describes abnormalities of both the cerebellar cortex and white matter and is associated with variable neurodevelopmental outcome. Dysplasia may globally involve the cerebellum or affect only one cerebellar hemisphere. In addition, cerebellar dysplasia may be associated with cortical/subcortical cysts.\nsynonyms :\n'}


{'id': 'HP_0007034', 'url': 'http://purl.obolibrary.org/obo/HP_0007034', 'lbl': 'Generalized hyperreflexia', 'desc': 'label: Generalized hyperreflexia\ndefinition : \nsynonyms :Generalised hyperreflexia\n'}


{'id': 'HP_0007035', 'url': 'http://purl.obolibrary.org/obo/HP_0007035', 'lbl': 'Anterior encephalocele', 'desc': 'label: Anterior encephalocele\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007036', 'url': 'http://purl.obolibrary.org/obo/HP_0007036', 'lbl': 'Hypoplasia of olfactory tract', 'desc': 'label: Hypoplasia of olfactory tract\ndefinition : \nsynonyms :Underdeveloped olfactory tract\n'}


{'id': 'HP_0007039', 'url': 'http://purl.obolibrary.org/obo/HP_0007039', 'lbl': 'Symmetric lesions of the basal ganglia', 'desc': 'label: Symmetric lesions of the basal ganglia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007041', 'url': 'http://purl.obolibrary.org/obo/HP_0007041', 'lbl': 'Chronic lymphocytic meningitis', 'desc': 'label: Chronic lymphocytic meningitis\ndefinition : Meningitis that persists for more than 4 weeks, and lymphocytes are present in the cerebrospinal fluid (CSF).\nsynonyms :\n'}


{'id': 'HP_0007042', 'url': 'http://purl.obolibrary.org/obo/HP_0007042', 'lbl': 'Focal white matter lesions', 'desc': 'label: Focal white matter lesions\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007045', 'url': 'http://purl.obolibrary.org/obo/HP_0007045', 'lbl': 'Midline brain calcifications', 'desc': 'label: Midline brain calcifications\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007047', 'url': 'http://purl.obolibrary.org/obo/HP_0007047', 'lbl': 'Atrophy of the dentate nucleus', 'desc': 'label: Atrophy of the dentate nucleus\ndefinition : Partial or complete wasting (loss) of dentate nucleus.\nsynonyms :\n'}


{'id': 'HP_0007048', 'url': 'http://purl.obolibrary.org/obo/HP_0007048', 'lbl': 'Large basal ganglia', 'desc': 'label: Large basal ganglia\ndefinition : Increased size of the basal ganglia.\nsynonyms :\n'}


{'id': 'HP_0007052', 'url': 'http://purl.obolibrary.org/obo/HP_0007052', 'lbl': 'Multifocal cerebral white matter abnormalities', 'desc': 'label: Multifocal cerebral white matter abnormalities\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007054', 'url': 'http://purl.obolibrary.org/obo/HP_0007054', 'lbl': 'Proximal hyperreflexia', 'desc': 'label: Proximal hyperreflexia\ndefinition : Hyperactive stretch reflexes of muscles that move proximal joints (elbow, knee).\nsynonyms :Hyperreflexia proximally\n'}


{'id': 'HP_0007057', 'url': 'http://purl.obolibrary.org/obo/HP_0007057', 'lbl': 'Poor hand-eye coordination', 'desc': 'label: Poor hand-eye coordination\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007058', 'url': 'http://purl.obolibrary.org/obo/HP_0007058', 'lbl': 'Generalized cerebral atrophy/hypoplasia', 'desc': 'label: Generalized cerebral atrophy/hypoplasia\ndefinition : Generalized atrophy or hypoplasia of the cerebrum.\nsynonyms :Generalised cerebral atrophy/hypoplasia; Generalised cerebral degeneration/underdevelopment; Generalized cerebral degeneration/underdevelopment\n'}


{'id': 'HP_0007063', 'url': 'http://purl.obolibrary.org/obo/HP_0007063', 'lbl': 'Aplasia of the inferior half of the cerebellar vermis', 'desc': 'label: Aplasia of the inferior half of the cerebellar vermis\ndefinition : \nsynonyms :Absent inferior half of the cerebellar vermis\n'}


{'id': 'HP_0007064', 'url': 'http://purl.obolibrary.org/obo/HP_0007064', 'lbl': 'Progressive language deterioration', 'desc': 'label: Progressive language deterioration\ndefinition : Progressive loss of previously present language abilities.\nsynonyms :\n'}


{'id': 'HP_0007065', 'url': 'http://purl.obolibrary.org/obo/HP_0007065', 'lbl': 'Disorganization of the anterior cerebellar vermis', 'desc': 'label: Disorganization of the anterior cerebellar vermis\ndefinition : \nsynonyms :Disorganisation of the anterior cerebellar vermis\n'}


{'id': 'HP_0007066', 'url': 'http://purl.obolibrary.org/obo/HP_0007066', 'lbl': 'Proximal limb muscle stiffness', 'desc': 'label: Proximal limb muscle stiffness\ndefinition : Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in the proximal limb muscle.\nsynonyms :\n'}


{'id': 'HP_0007067', 'url': 'http://purl.obolibrary.org/obo/HP_0007067', 'lbl': 'Distal peripheral sensory neuropathy', 'desc': 'label: Distal peripheral sensory neuropathy\ndefinition : Peripheral sensory neuropathy affecting primarily distal sensation.\nsynonyms :Peripheral sensory neuropathy, distal\n'}


{'id': 'HP_0007068', 'url': 'http://purl.obolibrary.org/obo/HP_0007068', 'lbl': 'Inferior cerebellar vermis hypoplasia', 'desc': 'label: Inferior cerebellar vermis hypoplasia\ndefinition : Underdevelopment of the inferior portion of the vermis of cerebellum.\nsynonyms :Hypoplasia of inferior vermis; Inferior vermis hypoplasia\n'}


{'id': 'HP_0007069', 'url': 'http://purl.obolibrary.org/obo/HP_0007069', 'lbl': 'Profound static encephalopathy', 'desc': 'label: Profound static encephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007074', 'url': 'http://purl.obolibrary.org/obo/HP_0007074', 'lbl': 'Thick corpus callosum', 'desc': 'label: Thick corpus callosum\ndefinition : Increased vertical dimension of the corpus callosum. This feature can be visualized by sagittal sections on magnetic resonance tomography imaging of the brain.\nsynonyms :Abnormal size of corpus callosum; Large corpus callosum\n'}


{'id': 'HP_0007076', 'url': 'http://purl.obolibrary.org/obo/HP_0007076', 'lbl': 'Extrapyramidal muscular rigidity', 'desc': 'label: Extrapyramidal muscular rigidity\ndefinition : Muscular rigidity (continuous contraction of muscles with constant resistance to passive movement).\nsynonyms :\n'}


{'id': 'HP_0007078', 'url': 'http://purl.obolibrary.org/obo/HP_0007078', 'lbl': 'Decreased amplitude of sensory action potentials', 'desc': 'label: Decreased amplitude of sensory action potentials\ndefinition : A reduction in the amplitude of sensory nerve action potential. This feature is measured by nerve conduction studies.\nsynonyms :\n'}


{'id': 'HP_0007081', 'url': 'http://purl.obolibrary.org/obo/HP_0007081', 'lbl': 'Late-onset muscular dystrophy', 'desc': 'label: Late-onset muscular dystrophy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007082', 'url': 'http://purl.obolibrary.org/obo/HP_0007082', 'lbl': 'Dilated third ventricle', 'desc': 'label: Dilated third ventricle\ndefinition : An increase in size of the third ventricle.\nsynonyms :\n'}


{'id': 'HP_0007083', 'url': 'http://purl.obolibrary.org/obo/HP_0007083', 'lbl': 'Hyperactive patellar reflex', 'desc': 'label: Hyperactive patellar reflex\ndefinition : \nsynonyms :Hyperreflexia in knees; Overactive knee reflex; Brisk knee jerk\n'}


{'id': 'HP_0007086', 'url': 'http://purl.obolibrary.org/obo/HP_0007086', 'lbl': 'Social and occupational deterioration', 'desc': 'label: Social and occupational deterioration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007087', 'url': 'http://purl.obolibrary.org/obo/HP_0007087', 'lbl': 'obsolete Involuntary jerking movements', 'desc': 'label: obsolete Involuntary jerking movements\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007089', 'url': 'http://purl.obolibrary.org/obo/HP_0007089', 'lbl': 'Facial-lingual fasciculations', 'desc': 'label: Facial-lingual fasciculations\ndefinition : Fasciculations affecting the tongue muscle and the musculature of the face.\nsynonyms :\n'}


{'id': 'HP_0007095', 'url': 'http://purl.obolibrary.org/obo/HP_0007095', 'lbl': 'obsolete Frontoparietal polymicrogyria', 'desc': 'label: obsolete Frontoparietal polymicrogyria\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007096', 'url': 'http://purl.obolibrary.org/obo/HP_0007096', 'lbl': 'Hypoplasia of the optic tract', 'desc': 'label: Hypoplasia of the optic tract\ndefinition : \nsynonyms :Underdeveloped optic tract\n'}


{'id': 'HP_0007097', 'url': 'http://purl.obolibrary.org/obo/HP_0007097', 'lbl': 'Cranial nerve motor loss', 'desc': 'label: Cranial nerve motor loss\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007098', 'url': 'http://purl.obolibrary.org/obo/HP_0007098', 'lbl': 'Paroxysmal choreoathetosis', 'desc': 'label: Paroxysmal choreoathetosis\ndefinition : Episodes of choreoathetosis that can occur following triggers such as quick voluntary movements.\nsynonyms :Choreoathetosis, episodic; Choreoathetosis, intermittent\n'}


{'id': 'HP_0007099', 'url': 'http://purl.obolibrary.org/obo/HP_0007099', 'lbl': 'Chiari type I malformation', 'desc': 'label: Chiari type I malformation\ndefinition : Arnold-Chiari type I malformation refers to a relatively mild degree of herniation of the posteroinferior region of the cerebellum (the cerebellar tonsils) into the cervical canal with little or no displacement of the fourth ventricle. It is characterized by one or both pointed (not rounded) cerebellar tonsils that project 5 mm below the foramen magnum, measured by a line drawn from the basion to the opisthion (McRae Line)\nsynonyms :Arnold Chiari type I malformation; Arnold-Chiari type I malformation; Chiari I malformation\n'}


{'id': 'HP_0007100', 'url': 'http://purl.obolibrary.org/obo/HP_0007100', 'lbl': 'Progressive ventriculomegaly', 'desc': 'label: Progressive ventriculomegaly\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007103', 'url': 'http://purl.obolibrary.org/obo/HP_0007103', 'lbl': 'Hypointensity of cerebral white matter on MRI', 'desc': 'label: Hypointensity of cerebral white matter on MRI\ndefinition : A darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter.\nsynonyms :White matter hypointensities on MRI\n'}


{'id': 'HP_0007104', 'url': 'http://purl.obolibrary.org/obo/HP_0007104', 'lbl': 'Prolonged somatosensory evoked potentials', 'desc': 'label: Prolonged somatosensory evoked potentials\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007105', 'url': 'http://purl.obolibrary.org/obo/HP_0007105', 'lbl': 'Infantile encephalopathy', 'desc': 'label: Infantile encephalopathy\ndefinition : Encephalopathy with onset in the infantile period.\nsynonyms :\n'}


{'id': 'HP_0007107', 'url': 'http://purl.obolibrary.org/obo/HP_0007107', 'lbl': 'Segmental peripheral demyelination', 'desc': 'label: Segmental peripheral demyelination\ndefinition : A loss of myelin from the internode regions along myelinated nerve fibers from segments of the peripheral nervous system.\nsynonyms :\n'}


{'id': 'HP_0007108', 'url': 'http://purl.obolibrary.org/obo/HP_0007108', 'lbl': 'Demyelinating peripheral neuropathy', 'desc': 'label: Demyelinating peripheral neuropathy\ndefinition : Demyelinating neuropathy is characterized by slow nerve conduction velocities with reduced amplitudes of sensory/motor nerve conduction and prolonged distal latencies.\nsynonyms :\n'}


{'id': 'HP_0007109', 'url': 'http://purl.obolibrary.org/obo/HP_0007109', 'lbl': 'Periventricular cysts', 'desc': 'label: Periventricular cysts\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007110', 'url': 'http://purl.obolibrary.org/obo/HP_0007110', 'lbl': 'Central hypoventilation', 'desc': 'label: Central hypoventilation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007111', 'url': 'http://purl.obolibrary.org/obo/HP_0007111', 'lbl': 'Chronic hepatic encephalopathy', 'desc': 'label: Chronic hepatic encephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007112', 'url': 'http://purl.obolibrary.org/obo/HP_0007112', 'lbl': 'Temporal cortical atrophy', 'desc': 'label: Temporal cortical atrophy\ndefinition : Atrophy of the temporal cortex.\nsynonyms :\n'}


{'id': 'HP_0007115', 'url': 'http://purl.obolibrary.org/obo/HP_0007115', 'lbl': 'Orbital encephalocele', 'desc': 'label: Orbital encephalocele\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007117', 'url': 'http://purl.obolibrary.org/obo/HP_0007117', 'lbl': 'Corticospinal tract atrophy', 'desc': 'label: Corticospinal tract atrophy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007123', 'url': 'http://purl.obolibrary.org/obo/HP_0007123', 'lbl': 'Subcortical dementia', 'desc': 'label: Subcortical dementia\ndefinition : A particular type of dementia characterized by a pattern of mental defects consisting prominently of forgetfulness, slowness of thought processes, and personality or mood change.\nsynonyms :\n'}


{'id': 'HP_0007126', 'url': 'http://purl.obolibrary.org/obo/HP_0007126', 'lbl': 'Proximal amyotrophy', 'desc': 'label: Proximal amyotrophy\ndefinition : Amyotrophy (muscular atrophy) affecting the proximal musculature.\nsynonyms :Muscle atrophy, proximal; Proximal muscle atrophy; Proximal muscle wasting; Symmetric proximal muscular atrophy; Symmetrical, proximal limb muscle atrophy; Wasting of muscles near the body\n'}


{'id': 'HP_0007129', 'url': 'http://purl.obolibrary.org/obo/HP_0007129', 'lbl': 'Cerebellar medulloblastoma', 'desc': 'label: Cerebellar medulloblastoma\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007131', 'url': 'http://purl.obolibrary.org/obo/HP_0007131', 'lbl': 'Acute demyelinating polyneuropathy', 'desc': 'label: Acute demyelinating polyneuropathy\ndefinition : Acute progressive areflexic weakness and mild sensory changes resulting from myelin breakdown and axonal degeneration.\nsynonyms :\n'}


{'id': 'HP_0007132', 'url': 'http://purl.obolibrary.org/obo/HP_0007132', 'lbl': 'Pallidal degeneration', 'desc': 'label: Pallidal degeneration\ndefinition : Neurodegeneration involving the globus pallidus,a part of the basal ganglia that is involved in the regulation of voluntary movement.\nsynonyms :\n'}


{'id': 'HP_0007133', 'url': 'http://purl.obolibrary.org/obo/HP_0007133', 'lbl': 'Progressive peripheral neuropathy', 'desc': 'label: Progressive peripheral neuropathy\ndefinition : \nsynonyms :Progressive polyneuropathy\n'}


{'id': 'HP_0007141', 'url': 'http://purl.obolibrary.org/obo/HP_0007141', 'lbl': 'Sensorimotor neuropathy', 'desc': 'label: Sensorimotor neuropathy\ndefinition : \nsynonyms :Mixed polyneuropathy; Nerve damage causing decreased feeling and movement; Sensorimotor peripheral neuropathy\n'}


{'id': 'HP_0007146', 'url': 'http://purl.obolibrary.org/obo/HP_0007146', 'lbl': 'Bilateral basal ganglia lesions', 'desc': 'label: Bilateral basal ganglia lesions\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007149', 'url': 'http://purl.obolibrary.org/obo/HP_0007149', 'lbl': 'Distal upper limb amyotrophy', 'desc': 'label: Distal upper limb amyotrophy\ndefinition : Muscular atrophy of distal arm muscles.\nsynonyms :Distal upper limb muscle atrophy\n'}


{'id': 'HP_0007153', 'url': 'http://purl.obolibrary.org/obo/HP_0007153', 'lbl': 'Progressive extrapyramidal movement disorder', 'desc': 'label: Progressive extrapyramidal movement disorder\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007156', 'url': 'http://purl.obolibrary.org/obo/HP_0007156', 'lbl': 'Asymmetric limb muscle stiffness', 'desc': 'label: Asymmetric limb muscle stiffness\ndefinition : Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in an asymmetric pattern.\nsynonyms :\n'}


{'id': 'HP_0007158', 'url': 'http://purl.obolibrary.org/obo/HP_0007158', 'lbl': 'Progressive extrapyramidal muscular rigidity', 'desc': 'label: Progressive extrapyramidal muscular rigidity\ndefinition : A progressive degree of muscular rigidity (continuous contraction of muscles with constant resistance to passive movement).\nsynonyms :Progressive extrapyramidal rigidity\n'}


{'id': 'HP_0007159', 'url': 'http://purl.obolibrary.org/obo/HP_0007159', 'lbl': 'Fluctuations in consciousness', 'desc': 'label: Fluctuations in consciousness\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007162', 'url': 'http://purl.obolibrary.org/obo/HP_0007162', 'lbl': 'Diffuse demyelination of the cerebral white matter', 'desc': 'label: Diffuse demyelination of the cerebral white matter\ndefinition : A diffuse loss of myelin from nerve fibers in the central nervous system.\nsynonyms :\n'}


{'id': 'HP_0007163', 'url': 'http://purl.obolibrary.org/obo/HP_0007163', 'lbl': 'obsolete Corticospinal tract disease in lower limbs', 'desc': 'label: obsolete Corticospinal tract disease in lower limbs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007164', 'url': 'http://purl.obolibrary.org/obo/HP_0007164', 'lbl': 'Slowed slurred speech', 'desc': 'label: Slowed slurred speech\ndefinition : \nsynonyms :Slowed slurred speech\n'}


{'id': 'HP_0007165', 'url': 'http://purl.obolibrary.org/obo/HP_0007165', 'lbl': 'Periventricular heterotopia', 'desc': 'label: Periventricular heterotopia\ndefinition : A form of gray matter heterotopia were the mislocalized gray matter is typically located periventricularly, also sometimes called subependymal heterotopia. Periventricular means beside the ventricles. This is by far the most common location for heterotopia. Subependymal heterotopia present in a wide array of variations. There can be a small single node or a large number of nodes, can exist on either or both sides of the brain at any point along the higher ventricle margins, can be small or large, single or multiple, and can form a small node or a large wavy or curved mass.\nsynonyms :Periventricular gray matter heterotopia; Periventricular grey matter heterotopia; Periventricular neuronal heterotopia; Subependymal gray matter heterotopia; Subependymal grey matter heterotopia; Subependymal neuronal heterotopia\n'}


{'id': 'HP_0007166', 'url': 'http://purl.obolibrary.org/obo/HP_0007166', 'lbl': 'Paroxysmal dyskinesia', 'desc': 'label: Paroxysmal dyskinesia\ndefinition : Episodic bouts of involuntary movements with dystonic, choreic, ballistic movements, or a combination thereof. There is no loss of consciousness during the attacks.\nsynonyms :Involuntary dystonic or choreiform movements\n'}


{'id': 'HP_0007178', 'url': 'http://purl.obolibrary.org/obo/HP_0007178', 'lbl': 'Motor polyneuropathy', 'desc': 'label: Motor polyneuropathy\ndefinition : \nsynonyms :Peripheral motor neuropathy\n'}


{'id': 'HP_0007179', 'url': 'http://purl.obolibrary.org/obo/HP_0007179', 'lbl': 'Absent smooth pursuit', 'desc': 'label: Absent smooth pursuit\ndefinition : A complete lack of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion.\nsynonyms :\n'}


{'id': 'HP_0007181', 'url': 'http://purl.obolibrary.org/obo/HP_0007181', 'lbl': 'Interosseus muscle atrophy', 'desc': 'label: Interosseus muscle atrophy\ndefinition : Atrophy of the interosseus muscles (including the palmar interossei that lie on the anterior aspect of the metacarpals, the dorsal interosseus muscles of the hand, which lie between the intercarpals, the plantar interosseus muscles, which lie underneath the metatarsal bones, and the dorsal interossei, which are located between the metatarsal bones.\nsynonyms :Interosseous muscular atrophy\n'}


{'id': 'HP_0007182', 'url': 'http://purl.obolibrary.org/obo/HP_0007182', 'lbl': 'Peripheral hypomyelination', 'desc': 'label: Peripheral hypomyelination\ndefinition : Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the peripheral nervous system.\nsynonyms :\n'}


{'id': 'HP_0007183', 'url': 'http://purl.obolibrary.org/obo/HP_0007183', 'lbl': 'Focal T2 hyperintense basal ganglia lesion', 'desc': 'label: Focal T2 hyperintense basal ganglia lesion\ndefinition : A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hyperintensity affecting a particular region of the basal ganglia.\nsynonyms :Hyperintense lesions in the basal ganglia on MRI\n'}


{'id': 'HP_0007185', 'url': 'http://purl.obolibrary.org/obo/HP_0007185', 'lbl': 'Loss of consciousness', 'desc': 'label: Loss of consciousness\ndefinition : \nsynonyms :Loss of consciousness; Passing out\n'}


{'id': 'HP_0007187', 'url': 'http://purl.obolibrary.org/obo/HP_0007187', 'lbl': 'Focal lissencephaly', 'desc': 'label: Focal lissencephaly\ndefinition : A congenital absence of the convolutions of the cerebral cortex and a poorly formed sylvian fissure that affects a particular part of the cortex.\nsynonyms :\n'}


{'id': 'HP_0007188', 'url': 'http://purl.obolibrary.org/obo/HP_0007188', 'lbl': 'Congenital facial diplegia', 'desc': 'label: Congenital facial diplegia\ndefinition : Facial diplegia (that is, bilateral facial palsy) with congenital onset.\nsynonyms :Congenital bilateral facial palsy; Congenital bilateral facial weakness\n'}


{'id': 'HP_0007190', 'url': 'http://purl.obolibrary.org/obo/HP_0007190', 'lbl': 'Neuronal loss in the cerebral cortex', 'desc': 'label: Neuronal loss in the cerebral cortex\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007193', 'url': 'http://purl.obolibrary.org/obo/HP_0007193', 'lbl': 'Bilateral tonic-clonic seizure on awakening', 'desc': 'label: Bilateral tonic-clonic seizure on awakening\ndefinition : Bilateral tonic-clonic seizure of either generalized or focal onset occurring on or soon after wakening (typically within 90 minutes of waking, regardless of the time of day).\nsynonyms :Generalised tonic-clonic seizures on awakening; Generalized tonic-clonic seizures on awakening; Morning generalised tonic-clonic seizures; Morning generalized tonic-clonic seizures\n'}


{'id': 'HP_0007199', 'url': 'http://purl.obolibrary.org/obo/HP_0007199', 'lbl': 'Progressive spastic paraparesis', 'desc': 'label: Progressive spastic paraparesis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007200', 'url': 'http://purl.obolibrary.org/obo/HP_0007200', 'lbl': 'Episodic hypersomnia', 'desc': 'label: Episodic hypersomnia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007201', 'url': 'http://purl.obolibrary.org/obo/HP_0007201', 'lbl': 'Cerebral artery atherosclerosis', 'desc': 'label: Cerebral artery atherosclerosis\ndefinition : The formation of the formation of fibrofatty lesions in the wall of an artery located in the brain.\nsynonyms :Plaque build-up in cerebral artery\n'}


{'id': 'HP_0007204', 'url': 'http://purl.obolibrary.org/obo/HP_0007204', 'lbl': 'Diffuse white matter abnormalities', 'desc': 'label: Diffuse white matter abnormalities\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007206', 'url': 'http://purl.obolibrary.org/obo/HP_0007206', 'lbl': 'Hemimegalencephaly', 'desc': 'label: Hemimegalencephaly\ndefinition : Enlargement of all or parts of one cerebral hemisphere.\nsynonyms :\n'}


{'id': 'HP_0007207', 'url': 'http://purl.obolibrary.org/obo/HP_0007207', 'lbl': 'Photosensitive tonic-clonic seizure', 'desc': 'label: Photosensitive tonic-clonic seizure\ndefinition : Generalized-onset tonic-clonic seizures that are provoked by flashing or flickering light.\nsynonyms :Photically induced tonic-clonic seizure; Photosensitive tonic-clonic seizures; Seizures, tonic-clonic, photosensitive\n'}


{'id': 'HP_0007208', 'url': 'http://purl.obolibrary.org/obo/HP_0007208', 'lbl': 'Irregular myelin loops', 'desc': 'label: Irregular myelin loops\ndefinition : Presence of irregular redundant loops of focally folded myelin in a peripheral nerve.\nsynonyms :\n'}


{'id': 'HP_0007209', 'url': 'http://purl.obolibrary.org/obo/HP_0007209', 'lbl': 'Facial paralysis', 'desc': 'label: Facial paralysis\ndefinition : Complete loss of ability to move facial muscles innervated by the facial nerve (i.e., the seventh cranial nerve).\nsynonyms :Facial paralysis; Facial paresis\n'}


{'id': 'HP_0007210', 'url': 'http://purl.obolibrary.org/obo/HP_0007210', 'lbl': 'Lower limb amyotrophy', 'desc': 'label: Lower limb amyotrophy\ndefinition : Muscular atrophy affecting the lower limb.\nsynonyms :\n'}


{'id': 'HP_0007215', 'url': 'http://purl.obolibrary.org/obo/HP_0007215', 'lbl': 'Periodic hyperkalemic paralysis', 'desc': 'label: Periodic hyperkalemic paralysis\ndefinition : Episodes of muscle weakness associated with elevated levels of potassium in the blood.\nsynonyms :Hyperkalemic periodic paralysis\n'}


{'id': 'HP_0007220', 'url': 'http://purl.obolibrary.org/obo/HP_0007220', 'lbl': 'Demyelinating motor neuropathy', 'desc': 'label: Demyelinating motor neuropathy\ndefinition : Demyelination of peripheral motor nerves.\nsynonyms :\n'}


{'id': 'HP_0007221', 'url': 'http://purl.obolibrary.org/obo/HP_0007221', 'lbl': 'Progressive truncal ataxia', 'desc': 'label: Progressive truncal ataxia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007227', 'url': 'http://purl.obolibrary.org/obo/HP_0007227', 'lbl': 'Macrogyria', 'desc': 'label: Macrogyria\ndefinition : Increased size of cerebral gyri, often associated with a moderate reduction in the number of sulci of the cerebrum.\nsynonyms :\n'}


{'id': 'HP_0007229', 'url': 'http://purl.obolibrary.org/obo/HP_0007229', 'lbl': 'Intracerebral periventricular calcifications', 'desc': 'label: Intracerebral periventricular calcifications\ndefinition : The presence of calcium deposition in the cerebral white matter surrounding the cerebral ventricles.\nsynonyms :\n'}


{'id': 'HP_0007230', 'url': 'http://purl.obolibrary.org/obo/HP_0007230', 'lbl': 'Decreased distal sensory nerve action potential', 'desc': 'label: Decreased distal sensory nerve action potential\ndefinition : A reduction in the amplitude of sensory nerve action potential in distal nerve segments. This feature is measured by nerve conduction studies.\nsynonyms :\n'}


{'id': 'HP_0007232', 'url': 'http://purl.obolibrary.org/obo/HP_0007232', 'lbl': 'Spinocerebellar tract disease in lower limbs', 'desc': 'label: Spinocerebellar tract disease in lower limbs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007233', 'url': 'http://purl.obolibrary.org/obo/HP_0007233', 'lbl': 'Clusters of axonal regeneration', 'desc': 'label: Clusters of axonal regeneration\ndefinition : Groups of small caliber axons in peripheral nerve biospies indicative of axonal regeneration.\nsynonyms :\n'}


{'id': 'HP_0007236', 'url': 'http://purl.obolibrary.org/obo/HP_0007236', 'lbl': 'Recurrent subcortical infarcts', 'desc': 'label: Recurrent subcortical infarcts\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007238', 'url': 'http://purl.obolibrary.org/obo/HP_0007238', 'lbl': 'Nonarteriosclerotic cerebral calcification', 'desc': 'label: Nonarteriosclerotic cerebral calcification\ndefinition : \nsynonyms :Cerebral calcification, nonarteriosclerotic\n'}


{'id': 'HP_0007239', 'url': 'http://purl.obolibrary.org/obo/HP_0007239', 'lbl': 'Congenital encephalopathy', 'desc': 'label: Congenital encephalopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007240', 'url': 'http://purl.obolibrary.org/obo/HP_0007240', 'lbl': 'Progressive gait ataxia', 'desc': 'label: Progressive gait ataxia\ndefinition : A type of gait ataxia displaying progression of clinical severity.\nsynonyms :Gait ataxia, progressive\n'}


{'id': 'HP_0007249', 'url': 'http://purl.obolibrary.org/obo/HP_0007249', 'lbl': 'Decreased number of small peripheral myelinated nerve fibers', 'desc': 'label: Decreased number of small peripheral myelinated nerve fibers\ndefinition : \nsynonyms :Decreased number of small peripheral myelinated nerve fibres\n'}


{'id': 'HP_0007250', 'url': 'http://purl.obolibrary.org/obo/HP_0007250', 'lbl': 'Recurrent external ophthalmoplegia', 'desc': 'label: Recurrent external ophthalmoplegia\ndefinition : Alternating and recurrent weakness of the external ocular muscles.\nsynonyms :\n'}


{'id': 'HP_0007256', 'url': 'http://purl.obolibrary.org/obo/HP_0007256', 'lbl': 'Abnormal pyramidal sign', 'desc': 'label: Abnormal pyramidal sign\ndefinition : Functional neurological abnormalities related to dysfunction of the pyramidal tract.\nsynonyms :Corticospinal signs; Pyramidal signs; Pyramidal tract signs\n'}


{'id': 'HP_0007258', 'url': 'http://purl.obolibrary.org/obo/HP_0007258', 'lbl': 'Severe demyelination of the white matter', 'desc': 'label: Severe demyelination of the white matter\ndefinition : A severe loss of myelin from nerve fibers in the central nervous system.\nsynonyms :\n'}


{'id': 'HP_0007260', 'url': 'http://purl.obolibrary.org/obo/HP_0007260', 'lbl': 'Type II lissencephaly', 'desc': "label: Type II lissencephaly\ndefinition : A form of lissencephaly characterized by an uneven cortical surface with a so called 'cobblestone' appearace. There are no distinguishable cortical layers.\nsynonyms :Cobblestone lissencephaly; Lissencephaly type II; Type 2 lissencephaly\n"}


{'id': 'HP_0007262', 'url': 'http://purl.obolibrary.org/obo/HP_0007262', 'lbl': 'Symmetric peripheral demyelination', 'desc': 'label: Symmetric peripheral demyelination\ndefinition : A symmetric loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.\nsynonyms :\n'}


{'id': 'HP_0007263', 'url': 'http://purl.obolibrary.org/obo/HP_0007263', 'lbl': 'Spinocerebellar atrophy', 'desc': 'label: Spinocerebellar atrophy\ndefinition : Atrophy affecting the cerebellum and the spinocerebellar tracts of the spinal cord.\nsynonyms :\n'}


{'id': 'HP_0007265', 'url': 'http://purl.obolibrary.org/obo/HP_0007265', 'lbl': 'Absent mesencephalon', 'desc': 'label: Absent mesencephalon\ndefinition : Agenesis of the midbrain.\nsynonyms :\n'}


{'id': 'HP_0007266', 'url': 'http://purl.obolibrary.org/obo/HP_0007266', 'lbl': 'Cerebral dysmyelination', 'desc': 'label: Cerebral dysmyelination\ndefinition : Defective structure and function of myelin sheaths of the white matter of the brain.\nsynonyms :Areas of dysmyelination on MRI; Dysmyelination of the brain; White matter dysmyelination/demyelination\n'}


{'id': 'HP_0007267', 'url': 'http://purl.obolibrary.org/obo/HP_0007267', 'lbl': 'Chronic axonal neuropathy', 'desc': 'label: Chronic axonal neuropathy\ndefinition : An abnormality characterized by chronic impairment of the normal functioning of the axons.\nsynonyms :Chronic sural axonal neuropathy\n'}


{'id': 'HP_0007268', 'url': 'http://purl.obolibrary.org/obo/HP_0007268', 'lbl': 'Aprosencephaly', 'desc': 'label: Aprosencephaly\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007269', 'url': 'http://purl.obolibrary.org/obo/HP_0007269', 'lbl': 'Spinal muscular atrophy', 'desc': 'label: Spinal muscular atrophy\ndefinition : Muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem.\nsynonyms :Spinal muscle degeneration; Spinal muscle wasting\n'}


{'id': 'HP_0007270', 'url': 'http://purl.obolibrary.org/obo/HP_0007270', 'lbl': 'Atypical absence seizure', 'desc': 'label: Atypical absence seizure\ndefinition : An atypical absence seizure is a type of generalised non-motor (absence) seizure characterised by interruption of ongoing activities and reduced responsiveness. In comparison to a typical absence seizure, changes in tone may be more pronounced, onset and/or cessation may be less abrupt, and the duration of the ictus and post-ictal recovery may be longer. Although not always available, an EEG often demonstrates slow (<3 Hz), irregular, generalized spike-wave activity.\nsynonyms :Atypical absence; Atypical absence seizures; Atypical petit mal seizures\n'}


{'id': 'HP_0007271', 'url': 'http://purl.obolibrary.org/obo/HP_0007271', 'lbl': 'Occipital myelomeningocele', 'desc': 'label: Occipital myelomeningocele\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007272', 'url': 'http://purl.obolibrary.org/obo/HP_0007272', 'lbl': 'Progressive psychomotor deterioration', 'desc': 'label: Progressive psychomotor deterioration\ndefinition : \nsynonyms :Progressive mental and motor deterioration\n'}


{'id': 'HP_0007274', 'url': 'http://purl.obolibrary.org/obo/HP_0007274', 'lbl': 'Recurrent bacterial meningitis', 'desc': 'label: Recurrent bacterial meningitis\ndefinition : An increased susceptibility to bacterial meningitis as manifested by a medical history of recurrent episodes of bacterial meningitis.\nsynonyms :\n'}


{'id': 'HP_0007277', 'url': 'http://purl.obolibrary.org/obo/HP_0007277', 'lbl': 'Paucity of anterior horn motor neurons', 'desc': 'label: Paucity of anterior horn motor neurons\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007280', 'url': 'http://purl.obolibrary.org/obo/HP_0007280', 'lbl': 'Acute infantile spinal muscular atrophy', 'desc': 'label: Acute infantile spinal muscular atrophy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007281', 'url': 'http://purl.obolibrary.org/obo/HP_0007281', 'lbl': 'Developmental stagnation', 'desc': 'label: Developmental stagnation\ndefinition : A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills.\nsynonyms :Developmental arrest\n'}


{'id': 'HP_0007285', 'url': 'http://purl.obolibrary.org/obo/HP_0007285', 'lbl': 'Facial palsy secondary to cranial hyperostosis', 'desc': 'label: Facial palsy secondary to cranial hyperostosis\ndefinition : Paralysis of the facial nerves on the basis of overgrowth of the cranial bones causing impingement upon the seventh cranial nerve.\nsynonyms :Facial palsy caused by enlargement of cranial bones; Facial palsy caused by excessive growth of facial bones; Facial palsy caused by overgrowth of cranial bones; Facial palsy secondary to hypertrophy of cranial bones\n'}


{'id': 'HP_0007286', 'url': 'http://purl.obolibrary.org/obo/HP_0007286', 'lbl': 'Horizontal jerk nystagmus', 'desc': 'label: Horizontal jerk nystagmus\ndefinition : Nystagmus consisting of horizontal to-and-fro eye movements, in which the movement in one direction is faster than in the other.\nsynonyms :\n'}


{'id': 'HP_0007289', 'url': 'http://purl.obolibrary.org/obo/HP_0007289', 'lbl': 'Limb fasciculations', 'desc': 'label: Limb fasciculations\ndefinition : Fasciculations affecting the musculature of the arms and legs.\nsynonyms :Limb fasciculation\n'}


{'id': 'HP_0007291', 'url': 'http://purl.obolibrary.org/obo/HP_0007291', 'lbl': 'Posterior fossa cyst', 'desc': 'label: Posterior fossa cyst\ndefinition : A discrete posterior fossa cerebrospinal fluid (CSF) collection that does not communicate directly with the fourth ventricle.\nsynonyms :\n'}


{'id': 'HP_0007293', 'url': 'http://purl.obolibrary.org/obo/HP_0007293', 'lbl': 'Anterior sacral meningocele', 'desc': 'label: Anterior sacral meningocele\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007295', 'url': 'http://purl.obolibrary.org/obo/HP_0007295', 'lbl': 'Chaotic rapid conjugate ocular movements', 'desc': 'label: Chaotic rapid conjugate ocular movements\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007299', 'url': 'http://purl.obolibrary.org/obo/HP_0007299', 'lbl': 'Dysfunction of lateral corticospinal tracts', 'desc': 'label: Dysfunction of lateral corticospinal tracts\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007301', 'url': 'http://purl.obolibrary.org/obo/HP_0007301', 'lbl': 'Oromotor apraxia', 'desc': 'label: Oromotor apraxia\ndefinition : Oral-motor apraxia is the inability to volitionally sequence oral movements of the speech structure for nonspeech tasks in the absence of neuromuscular deficits such as paralysis or muscle weakness. Oral-motor apraxia is diagnosed when, despite intact sensory motor function an individual is unable to use these effector systems under voluntary control.\nsynonyms :Oral-motor apraxia\n'}


{'id': 'HP_0007302', 'url': 'http://purl.obolibrary.org/obo/HP_0007302', 'lbl': 'Bipolar affective disorder', 'desc': 'label: Bipolar affective disorder\ndefinition : \nsynonyms :Bipolar disorder\n'}


{'id': 'HP_0007305', 'url': 'http://purl.obolibrary.org/obo/HP_0007305', 'lbl': 'CNS demyelination', 'desc': 'label: CNS demyelination\ndefinition : A loss of myelin from nerve fibers in the central nervous system.\nsynonyms :Demyelination in central white matter\n'}


{'id': 'HP_0007307', 'url': 'http://purl.obolibrary.org/obo/HP_0007307', 'lbl': 'Rapid neurologic deterioration', 'desc': 'label: Rapid neurologic deterioration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007308', 'url': 'http://purl.obolibrary.org/obo/HP_0007308', 'lbl': 'Extrapyramidal dyskinesia', 'desc': 'label: Extrapyramidal dyskinesia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007311', 'url': 'http://purl.obolibrary.org/obo/HP_0007311', 'lbl': 'Short stepped shuffling gait', 'desc': 'label: Short stepped shuffling gait\ndefinition : \nsynonyms :Short stepped shuffling walk\n'}


{'id': 'HP_0007313', 'url': 'http://purl.obolibrary.org/obo/HP_0007313', 'lbl': 'Cerebral degeneration', 'desc': 'label: Cerebral degeneration\ndefinition : \nsynonyms :Neuroaxonal degeneration in the brain\n'}


{'id': 'HP_0007314', 'url': 'http://purl.obolibrary.org/obo/HP_0007314', 'lbl': 'obsolete White matter neuronal heterotopia', 'desc': 'label: obsolete White matter neuronal heterotopia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007316', 'url': 'http://purl.obolibrary.org/obo/HP_0007316', 'lbl': 'obsolete Involuntary writhing movements', 'desc': 'label: obsolete Involuntary writhing movements\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007321', 'url': 'http://purl.obolibrary.org/obo/HP_0007321', 'lbl': 'Deep white matter hypodensities', 'desc': 'label: Deep white matter hypodensities\ndefinition : Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the deep cerebral white matter.\nsynonyms :Deep cerebral white matter hypodensities\n'}


{'id': 'HP_0007325', 'url': 'http://purl.obolibrary.org/obo/HP_0007325', 'lbl': 'Generalized dystonia', 'desc': 'label: Generalized dystonia\ndefinition : A type of dystonia that affects all or most of the body.\nsynonyms :Generalised dystonia\n'}


{'id': 'HP_0007326', 'url': 'http://purl.obolibrary.org/obo/HP_0007326', 'lbl': 'Progressive choreoathetosis', 'desc': 'label: Progressive choreoathetosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007327', 'url': 'http://purl.obolibrary.org/obo/HP_0007327', 'lbl': 'Mixed demyelinating and axonal polyneuropathy', 'desc': 'label: Mixed demyelinating and axonal polyneuropathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007328', 'url': 'http://purl.obolibrary.org/obo/HP_0007328', 'lbl': 'Impaired pain sensation', 'desc': 'label: Impaired pain sensation\ndefinition : Reduced ability to perceive painful stimuli.\nsynonyms :Decreased pain sensation; Decreased pinprick sensation; Impaired pain sensation\n'}


{'id': 'HP_0007330', 'url': 'http://purl.obolibrary.org/obo/HP_0007330', 'lbl': 'Frontal encephalocele', 'desc': 'label: Frontal encephalocele\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007332', 'url': 'http://purl.obolibrary.org/obo/HP_0007332', 'lbl': 'Focal hemifacial clonic seizure', 'desc': 'label: Focal hemifacial clonic seizure\ndefinition : Focal seizure characterized at onset by clonic movements affecting half of the face.\nsynonyms :Hemifacial seizures\n'}


{'id': 'HP_0007333', 'url': 'http://purl.obolibrary.org/obo/HP_0007333', 'lbl': 'Hypoplasia of the frontal lobes', 'desc': 'label: Hypoplasia of the frontal lobes\ndefinition : Underdevelopment of the frontal lobe of the cerebrum.\nsynonyms :Frontal lobe hypoplasia; Hypoplastic frontal lobes; Underdeveloped frontal lobe\n'}


{'id': 'HP_0007334', 'url': 'http://purl.obolibrary.org/obo/HP_0007334', 'lbl': 'Bilateral tonic-clonic seizure with focal onset', 'desc': 'label: Bilateral tonic-clonic seizure with focal onset\ndefinition : A bilateral tonic-clonic seizure with focal onset is a focal-onset seizure which progresses into a bilateral tonic-clonic phase.\nsynonyms :Focal seizure with secondary generalisation; Focal seizure with secondary generalization; Focal to bilateral tonic-clonic seizure; Generalised tonic-clonic seizure with focal onset; Generalised tonic-clonic seizure with partial onset; Generalised tonic-clonic seizures with focal onset; Generalized tonic-clonic seizure with focal onset; Generalized tonic-clonic seizure with partial onset; Generalized tonic-clonic seizures with focal onset; Partial seizure with secondary generalisation; Partial seizure with secondary generalization; Partial seizures with secondary generalisation; Partial seizures with secondary generalization; Secondarily generalised tonic-clonic seizure; Secondarily generalised tonic-clonic seizures; Secondarily generalized tonic-clonic seizure; Secondary generalised tonic clonic seizures; Secondary generalised tonic-clonic seizures; Secondary generalized tonic clonic seizures; Secondary generalized tonic-clonic seizures\n'}


{'id': 'HP_0007335', 'url': 'http://purl.obolibrary.org/obo/HP_0007335', 'lbl': 'Recurrent encephalopathy', 'desc': 'label: Recurrent encephalopathy\ndefinition : Recurrent episodes of brain dysfunction that may be triggered by factors such as metabolic disturbances or infections.\nsynonyms :Recurrent cerebellar and extrapyramidal encephalopathy\n'}


{'id': 'HP_0007338', 'url': 'http://purl.obolibrary.org/obo/HP_0007338', 'lbl': 'Hypermetric saccades', 'desc': 'label: Hypermetric saccades\ndefinition : A saccade that overshoots the target with the dynamic saccade.\nsynonyms :\n'}


{'id': 'HP_0007340', 'url': 'http://purl.obolibrary.org/obo/HP_0007340', 'lbl': 'Lower limb muscle weakness', 'desc': 'label: Lower limb muscle weakness\ndefinition : Weakness of the muscles of the legs.\nsynonyms :Lower extremity weakness; Lower limb muscle weakness; Lower limb weakness; Muscle weakness in lower limbs; Leg weakness\n'}


{'id': 'HP_0007341', 'url': 'http://purl.obolibrary.org/obo/HP_0007341', 'lbl': 'Diffuse swelling of cerebral white matter', 'desc': 'label: Diffuse swelling of cerebral white matter\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007343', 'url': 'http://purl.obolibrary.org/obo/HP_0007343', 'lbl': 'Abnormal morphology of the limbic system', 'desc': "label: Abnormal morphology of the limbic system\ndefinition : Any structural anomaly of the limbic system, a set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex].\nsynonyms :Limbic malformation\n"}


{'id': 'HP_0007344', 'url': 'http://purl.obolibrary.org/obo/HP_0007344', 'lbl': 'Atrophy/Degeneration involving the spinal cord', 'desc': 'label: Atrophy/Degeneration involving the spinal cord\ndefinition : \nsynonyms :Atrophic and degenerative changes in the spinal cord\n'}


{'id': 'HP_0007346', 'url': 'http://purl.obolibrary.org/obo/HP_0007346', 'lbl': 'Subcortical white matter calcifications', 'desc': 'label: Subcortical white matter calcifications\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007348', 'url': 'http://purl.obolibrary.org/obo/HP_0007348', 'lbl': 'Hypoplasia of the pyramidal tract', 'desc': 'label: Hypoplasia of the pyramidal tract\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007350', 'url': 'http://purl.obolibrary.org/obo/HP_0007350', 'lbl': 'Hyperreflexia in upper limbs', 'desc': 'label: Hyperreflexia in upper limbs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007351', 'url': 'http://purl.obolibrary.org/obo/HP_0007351', 'lbl': 'Upper limb postural tremor', 'desc': 'label: Upper limb postural tremor\ndefinition : A type of tremors that is triggered by holding an arm in a fixed position.\nsynonyms :Postural tremor of arms\n'}


{'id': 'HP_0007352', 'url': 'http://purl.obolibrary.org/obo/HP_0007352', 'lbl': 'Cerebellar calcifications', 'desc': 'label: Cerebellar calcifications\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007354', 'url': 'http://purl.obolibrary.org/obo/HP_0007354', 'lbl': 'Amyotrophic lateral sclerosis', 'desc': "label: Amyotrophic lateral sclerosis\ndefinition : \nsynonyms :Lou Gehrig's disease\n"}


{'id': 'HP_0007359', 'url': 'http://purl.obolibrary.org/obo/HP_0007359', 'lbl': 'Focal-onset seizure', 'desc': 'label: Focal-onset seizure\ndefinition : A focal-onset seizure is a type of seizure originating within networks limited to one hemisphere. They may be discretely localized or more widely distributed, and may originate in subcortical structures.\nsynonyms :Focal onset seizure; Focal seizure; Focal seizures; Focal-onset seizures; Partial seizure; Partial seizures; Seizure affecting one half of brain\n'}


{'id': 'HP_0007360', 'url': 'http://purl.obolibrary.org/obo/HP_0007360', 'lbl': 'Aplasia/Hypoplasia of the cerebellum', 'desc': 'label: Aplasia/Hypoplasia of the cerebellum\ndefinition : \nsynonyms :Absent/small cerebellum; Absent/underdeveloped cerebellum; Atrophy/Degeneration affecting the cerebellum; Atrophy/Hypoplasia of the cerebellum; Cerebellar hypoplasia/atrophy\n'}


{'id': 'HP_0007361', 'url': 'http://purl.obolibrary.org/obo/HP_0007361', 'lbl': 'Abnormal pons morphology', 'desc': 'label: Abnormal pons morphology\ndefinition : A structural abnormality of the pons.\nsynonyms :Abnormality of the pons\n'}


{'id': 'HP_0007362', 'url': 'http://purl.obolibrary.org/obo/HP_0007362', 'lbl': 'Aplasia/Hypoplasia of the brainstem', 'desc': 'label: Aplasia/Hypoplasia of the brainstem\ndefinition : \nsynonyms :Absent/small brainstem; Absent/underdeveloped brainstem\n'}


{'id': 'HP_0007363', 'url': 'http://purl.obolibrary.org/obo/HP_0007363', 'lbl': 'Aplasia/Hypoplasia of the pyramidal tract', 'desc': 'label: Aplasia/Hypoplasia of the pyramidal tract\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007364', 'url': 'http://purl.obolibrary.org/obo/HP_0007364', 'lbl': 'Aplasia/Hypoplasia of the cerebrum', 'desc': 'label: Aplasia/Hypoplasia of the cerebrum\ndefinition : \nsynonyms :Absent/small cerebrum; Absent/underdeveloped cerebrum\n'}


{'id': 'HP_0007365', 'url': 'http://purl.obolibrary.org/obo/HP_0007365', 'lbl': 'Aplasia/Hypoplasia involving the corticospinal tracts', 'desc': 'label: Aplasia/Hypoplasia involving the corticospinal tracts\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007366', 'url': 'http://purl.obolibrary.org/obo/HP_0007366', 'lbl': 'Atrophy/Degeneration affecting the brainstem', 'desc': 'label: Atrophy/Degeneration affecting the brainstem\ndefinition : \nsynonyms :Brainstem atrophy\n'}


{'id': 'HP_0007367', 'url': 'http://purl.obolibrary.org/obo/HP_0007367', 'lbl': 'Atrophy/Degeneration affecting the central nervous system', 'desc': 'label: Atrophy/Degeneration affecting the central nervous system\ndefinition : \nsynonyms :Atrophy/Degeneration affecting the CNS\n'}


{'id': 'HP_0007369', 'url': 'http://purl.obolibrary.org/obo/HP_0007369', 'lbl': 'Atrophy/Degeneration affecting the cerebrum', 'desc': 'label: Atrophy/Degeneration affecting the cerebrum\ndefinition : The presence of atrophy (wasting) of the cerebrum, also known as the telencephalon, the largest and most highly developed part of the human brain.\nsynonyms :\n'}


{'id': 'HP_0007370', 'url': 'http://purl.obolibrary.org/obo/HP_0007370', 'lbl': 'Aplasia/Hypoplasia of the corpus callosum', 'desc': 'label: Aplasia/Hypoplasia of the corpus callosum\ndefinition : Absence or underdevelopment of the corpus callosum.\nsynonyms :Absent/hypoplastic corpus callosum; Agenesis/hypoplastic corpus callosum; Complete or partial absence of the corpus callosum; Hypoplasia or absence of the corpus callosum; Hypoplastic or absent corpus callosum\n'}


{'id': 'HP_0007371', 'url': 'http://purl.obolibrary.org/obo/HP_0007371', 'lbl': 'Corpus callosum atrophy', 'desc': 'label: Corpus callosum atrophy\ndefinition : The presence of atrophy (wasting) of the corpus callosum.\nsynonyms :Atrophic corpus callosum; Atrophy of the corpus callosum; Atrophy/Degeneration of the corpus callosum\n'}


{'id': 'HP_0007372', 'url': 'http://purl.obolibrary.org/obo/HP_0007372', 'lbl': 'Atrophy/Degeneration involving the corticospinal tracts', 'desc': 'label: Atrophy/Degeneration involving the corticospinal tracts\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007373', 'url': 'http://purl.obolibrary.org/obo/HP_0007373', 'lbl': 'Motor neuron atrophy', 'desc': 'label: Motor neuron atrophy\ndefinition : Wasting involving the motor neuron.\nsynonyms :Motor neuron degeneration\n'}


{'id': 'HP_0007374', 'url': 'http://purl.obolibrary.org/obo/HP_0007374', 'lbl': 'Atrophy/Degeneration involving the caudate nucleus', 'desc': 'label: Atrophy/Degeneration involving the caudate nucleus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007375', 'url': 'http://purl.obolibrary.org/obo/HP_0007375', 'lbl': 'Abnormal septum pellucidum morphology', 'desc': 'label: Abnormal septum pellucidum morphology\ndefinition : An abnormality of the septum pellucidum, which is a thin, triangular, vertical membrane separating the lateral ventricles of the brain.\nsynonyms :Abnormality of the septum pellucidum\n'}


{'id': 'HP_0007376', 'url': 'http://purl.obolibrary.org/obo/HP_0007376', 'lbl': 'Abnormal choroid plexus morphology', 'desc': 'label: Abnormal choroid plexus morphology\ndefinition : An abnormality of the choroid plexus, which is the area in the cerebral ventricles in which cerebrospinal fluid is produced by modified ependymal cells.\nsynonyms :\n'}


{'id': 'HP_0007377', 'url': 'http://purl.obolibrary.org/obo/HP_0007377', 'lbl': 'Abnormality of somatosensory evoked potentials', 'desc': 'label: Abnormality of somatosensory evoked potentials\ndefinition : An abnormality of somatosensory evoked potentials (SSEP), i.e., of the electrical signals of sensation going from the body to the brain in response to a defined stimulus. Recording electrodes are placed over the scalp, spine, and peripheral nerves proximal to the stimulation site. Clinical studies generally use electrical stimulation of peripheral nerves to elicit potentials. SSEP testing determines whether peripheral sensory nerves are able to transmit sensory information like pain, temperature, and touch to the brain. Abnormal SSEPs can result from dysfunction at the level of the peripheral nerve, plexus, spinal root, spinal cord, brain stem, thalamocortical projections, or primary somatosensory cortex.\nsynonyms :Abnormality of SSEPs\n'}


{'id': 'HP_0007378', 'url': 'http://purl.obolibrary.org/obo/HP_0007378', 'lbl': 'Neoplasm of the gastrointestinal tract', 'desc': 'label: Neoplasm of the gastrointestinal tract\ndefinition : A tumor (abnormal growth of tissue) of the gastrointestinal tract.\nsynonyms :GI tract tumor; GI tract tumour; Gastrointestinal tract neoplasia; Gastrointestinal tract neoplasm; Gastrointestinal tract tumor; Gastrointestinal tract tumour; Neoplasm of the GI tract\n'}


{'id': 'HP_0007379', 'url': 'http://purl.obolibrary.org/obo/HP_0007379', 'lbl': 'Neoplasm of the genitourinary tract', 'desc': 'label: Neoplasm of the genitourinary tract\ndefinition : A tumor (abnormal growth of tissue) of the genitourinary system.\nsynonyms :Genitourinary tract neoplasm; Genitourinary tract tumors; Genitourinary tract tumours; Neoplasm of the GU tract; Genitourinary tract neoplasia\n'}


{'id': 'HP_0007380', 'url': 'http://purl.obolibrary.org/obo/HP_0007380', 'lbl': 'Facial telangiectasia', 'desc': 'label: Facial telangiectasia\ndefinition : Telangiectases (small dilated blood vessels) located near the surface of the skin of the face.\nsynonyms :Facial telangiectatic vessels; Telangiectasia, facial\n'}


{'id': 'HP_0007381', 'url': 'http://purl.obolibrary.org/obo/HP_0007381', 'lbl': 'Congenital exfoliative erythroderma', 'desc': 'label: Congenital exfoliative erythroderma\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007383', 'url': 'http://purl.obolibrary.org/obo/HP_0007383', 'lbl': 'Congenital localized absence of skin', 'desc': 'label: Congenital localized absence of skin\ndefinition : \nsynonyms :Congenital localised absence of skin; Congenital localised skin absence; Congenital localized skin absence\n'}


{'id': 'HP_0007384', 'url': 'http://purl.obolibrary.org/obo/HP_0007384', 'lbl': 'Aberrant melanosome maturation', 'desc': 'label: Aberrant melanosome maturation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007385', 'url': 'http://purl.obolibrary.org/obo/HP_0007385', 'lbl': 'Aplasia cutis congenita of scalp', 'desc': 'label: Aplasia cutis congenita of scalp\ndefinition : A developmental defect resulting in the congenital absence of skin on the scalp.\nsynonyms :Defect of scalp; Focal absence of scalp tissue; Scalp defect; Solitary scalp defect; Scalp aplasia cutis congenita\n'}


{'id': 'HP_0007387', 'url': 'http://purl.obolibrary.org/obo/HP_0007387', 'lbl': 'Hypoplastic sweat glands', 'desc': 'label: Hypoplastic sweat glands\ndefinition : Underdevelopment of the sweat glands.\nsynonyms :Underdeveloped sweat glands\n'}


{'id': 'HP_0007390', 'url': 'http://purl.obolibrary.org/obo/HP_0007390', 'lbl': 'Hyperkeratosis with erythema', 'desc': 'label: Hyperkeratosis with erythema\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007392', 'url': 'http://purl.obolibrary.org/obo/HP_0007392', 'lbl': 'Excessive wrinkled skin', 'desc': 'label: Excessive wrinkled skin\ndefinition : \nsynonyms :Excessive wrinkled skin\n'}


{'id': 'HP_0007394', 'url': 'http://purl.obolibrary.org/obo/HP_0007394', 'lbl': 'Prominent superficial blood vessels', 'desc': 'label: Prominent superficial blood vessels\ndefinition : \nsynonyms :Prominent superficial blood vessels; Prominent superficial vasculature\n'}


{'id': 'HP_0007395', 'url': 'http://purl.obolibrary.org/obo/HP_0007395', 'lbl': 'Postnatal-onset ichthyosiform erythroderma', 'desc': 'label: Postnatal-onset ichthyosiform erythroderma\ndefinition : A type of ichthyosiform erythroderma with postnatal onset.\nsynonyms :Postnatal-onset ichthyosis\n'}


{'id': 'HP_0007396', 'url': 'http://purl.obolibrary.org/obo/HP_0007396', 'lbl': 'Early cutaneous photosensitivity', 'desc': 'label: Early cutaneous photosensitivity\ndefinition : Photosensitivity of the skin occurring early in life.\nsynonyms :Sun sensitivity occurring early in life\n'}


{'id': 'HP_0007397', 'url': 'http://purl.obolibrary.org/obo/HP_0007397', 'lbl': 'Axillary apocrine gland hypoplasia', 'desc': 'label: Axillary apocrine gland hypoplasia\ndefinition : Developmental hypoplasia of the apocrine sweat glands in the region of the axilla.\nsynonyms :\n'}


{'id': 'HP_0007398', 'url': 'http://purl.obolibrary.org/obo/HP_0007398', 'lbl': 'Asymmetric, linear skin defects', 'desc': 'label: Asymmetric, linear skin defects\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007400', 'url': 'http://purl.obolibrary.org/obo/HP_0007400', 'lbl': 'Irregular hyperpigmentation', 'desc': 'label: Irregular hyperpigmentation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007401', 'url': 'http://purl.obolibrary.org/obo/HP_0007401', 'lbl': 'Macular atrophy', 'desc': 'label: Macular atrophy\ndefinition : Well-demarcated area(s) of partial or complete depigmentation in the macula, reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss.\nsynonyms :\n'}


{'id': 'HP_0007402', 'url': 'http://purl.obolibrary.org/obo/HP_0007402', 'lbl': 'Areas of hypopigmentation and hyperpigmentation that do not follow Blaschko lines', 'desc': 'label: Areas of hypopigmentation and hyperpigmentation that do not follow Blaschko lines\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007403', 'url': 'http://purl.obolibrary.org/obo/HP_0007403', 'lbl': 'Hypertrophy of skin of soles', 'desc': 'label: Hypertrophy of skin of soles\ndefinition : \nsynonyms :Thick skin of soles\n'}


{'id': 'HP_0007404', 'url': 'http://purl.obolibrary.org/obo/HP_0007404', 'lbl': 'Nonepidermolytic palmoplantar hyperkeratosis', 'desc': 'label: Nonepidermolytic palmoplantar hyperkeratosis\ndefinition : Abnormal thickening of the skin on the palms and soles charactersized by hyperkeratosis of the stratum corneum with no evidence of epidermolysis characteristic of epidermolytic hyperkeratosis.\nsynonyms :Nonepidermolytic palmoplantar keratoderma\n'}