{'id': 'HP_0031006', 'url': 'http://purl.obolibrary.org/obo/HP_0031006', 'lbl': 'Acroparesthesia', 'desc': 'label: Acroparesthesia\ndefinition : A type of paresthesia (tingling, pins-and-needles, burning or numbness or stiffness) that occurs in the hands and feet and particularly in the fingers and toes.\nsynonyms :\n'}


{'id': 'HP_0031007', 'url': 'http://purl.obolibrary.org/obo/HP_0031007', 'lbl': 'Orofacial action-specific dystonia induced by speech', 'desc': 'label: Orofacial action-specific dystonia induced by speech\ndefinition : \nsynonyms :Jaw dystonia induced by speaking\n'}


{'id': 'HP_0031008', 'url': 'http://purl.obolibrary.org/obo/HP_0031008', 'lbl': 'Lingual dystonia', 'desc': 'label: Lingual dystonia\ndefinition : Involuntary protrusions, movements, spams and contortions of the tongue.\nsynonyms :Tongue dystonia\n'}


{'id': 'HP_0031009', 'url': 'http://purl.obolibrary.org/obo/HP_0031009', 'lbl': 'Ainhum', 'desc': 'label: Ainhum\ndefinition : Development of a fibrotic constriction ring involving the base of one or more toes, conditioning eversion and absorption of distal structures, possibly progressing to spontaneous amputation.\nsynonyms :Dactylolysis spontanea\n'}


{'id': 'HP_0031010', 'url': 'http://purl.obolibrary.org/obo/HP_0031010', 'lbl': 'Hyperphalangy of the 3rd finger', 'desc': 'label: Hyperphalangy of the 3rd finger\ndefinition : An accessory phalanx of the third (middle) finger that is arranged linearly with the other phalanges. Hyperphalangy results from an accessory ossification center at the metacarpophalangeal joint.\nsynonyms :Hyperphalangy of third finger\n'}


{'id': 'HP_0031011', 'url': 'http://purl.obolibrary.org/obo/HP_0031011', 'lbl': 'Fatty streak', 'desc': 'label: Fatty streak\ndefinition : Yellow-colored streaks, patches, or spots on the intimal surface of arteries. Fatty streaks stain red with Sudan III or Sudan IV.\nsynonyms :Sudanophilic lesion\n'}


{'id': 'HP_0031012', 'url': 'http://purl.obolibrary.org/obo/HP_0031012', 'lbl': 'Thin-cap fibroatheroma', 'desc': 'label: Thin-cap fibroatheroma\ndefinition : Thin-cap fibroatheroma is characterized by a relatively large necrotic core with an overlying thin fibrous cap measuring less than 65 micrometers and typically containing numerous macrophages, and is considered to be the precursor lesion of plaque rupture which is the most common cause of coronary thrombosis.\nsynonyms :TCFA\n'}


{'id': 'HP_0031013', 'url': 'http://purl.obolibrary.org/obo/HP_0031013', 'lbl': 'Ankylosis', 'desc': 'label: Ankylosis\ndefinition : A reduction of joint mobility resulting from changes involving the articular surfaces.\nsynonyms :\n'}


{'id': 'HP_0031014', 'url': 'http://purl.obolibrary.org/obo/HP_0031014', 'lbl': 'Arteria lusoria', 'desc': 'label: Arteria lusoria\ndefinition : Usually, three large arteries arise from the arch of the aorta: the brachiocephalic trunk (divided into the right common carotid artery and the right subclavian artery), the left common carotid artery, and the left subclavian artery. However, when aberrant right subclavian artery variant is present, the brachiocephalic trunk is absent and four large arteries arise from the arch of the aorta: the right common carotid artery, the left common carotid artery, the left subclavian artery, and the final one with the most distal left sided origin, the right subclavian artery, also called the arteria lusoria.\nsynonyms :Aberrant right subclavian artery; Lusorian artery\n'}


{'id': 'HP_0031015', 'url': 'http://purl.obolibrary.org/obo/HP_0031015', 'lbl': 'Intrahepatic portal vein sclerosis', 'desc': 'label: Intrahepatic portal vein sclerosis\ndefinition : Sclerosis of the intrahepatic portal veins of the liver and generally accompanied by non-cirrhotic portal hypertension, features of which may include splenomegaly and varices.\nsynonyms :Idiopathic non-cirrhotic portal hypertension; Incomplete septal cirrhosis; Non cirrhotic portal fibrosis; Obliterative portal venopathy\n'}


{'id': 'HP_0031016', 'url': 'http://purl.obolibrary.org/obo/HP_0031016', 'lbl': 'Alternating radiolucent and radiodense metaphyseal lines', 'desc': 'label: Alternating radiolucent and radiodense metaphyseal lines\ndefinition : Areas of radio-opaque sclerotic bands alternating with those of normal lucency give rise to stripes akin to a zebra.\nsynonyms :Zebra stripe sign\n'}


{'id': 'HP_0031017', 'url': 'http://purl.obolibrary.org/obo/HP_0031017', 'lbl': 'Swiss cheese atrial septal defect', 'desc': 'label: Swiss cheese atrial septal defect\ndefinition : Multiple defects in the atrial septum.\nsynonyms :\n'}


{'id': 'HP_0031018', 'url': 'http://purl.obolibrary.org/obo/HP_0031018', 'lbl': 'Eccrine syringofibroadenoma', 'desc': 'label: Eccrine syringofibroadenoma\ndefinition : Eccrine syringofibroadenoma (ESFA) is a benign adnexal tumor arising most often on the extremities of elderly individuals characterized by anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells and ductal structures. ESFA stains positively with epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA).\nsynonyms :Acrosyringeal adenomatosis; Eccrine syringofibroadenomatous hyperplasia; Syringofibroadenoma\n'}


{'id': 'HP_0031019', 'url': 'http://purl.obolibrary.org/obo/HP_0031019', 'lbl': 'Pyknotic bone marrow neutrophils', 'desc': 'label: Pyknotic bone marrow neutrophils\ndefinition : Nuclear lobes of neutrophils in the bone marrow are thickened and condensed, and individual lobes are connected by unusually long chromatin filaments.\nsynonyms :\n'}


{'id': 'HP_0031020', 'url': 'http://purl.obolibrary.org/obo/HP_0031020', 'lbl': 'Bone marrow hypercellularity', 'desc': 'label: Bone marrow hypercellularity\ndefinition : A larger than normal amount or percentage of hematopoietic cells relative to marrow fat.\nsynonyms :\n'}


{'id': 'HP_0031021', 'url': 'http://purl.obolibrary.org/obo/HP_0031021', 'lbl': 'Squamous Papilloma', 'desc': 'label: Squamous Papilloma\ndefinition : A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy [NCI thesaurus].\nsynonyms :\n'}


{'id': 'HP_0031022', 'url': 'http://purl.obolibrary.org/obo/HP_0031022', 'lbl': 'Oropharyngeal squamous papilloma', 'desc': 'label: Oropharyngeal squamous papilloma\ndefinition : A benign exophytic neoplasm that arises from the oropharynx. It is characterized by the presence of a connective tissue core covered by stratified squamous epithelium [NCI thesaurus].\nsynonyms :Squamous papilloma of the uvula\n'}


{'id': 'HP_0031023', 'url': 'http://purl.obolibrary.org/obo/HP_0031023', 'lbl': 'Multiple mucosal neuromas', 'desc': 'label: Multiple mucosal neuromas\ndefinition : Multiple painful, dome-shaped, translucent pink to skin-colored papules on oral mucosa. Histologically, the lesions may demonstrate dermal proliferation of well-demarcated nerve bundles associated with abundant mucin and surrounded by a distinct perineural sheath.\nsynonyms :\n'}


{'id': 'HP_0031024', 'url': 'http://purl.obolibrary.org/obo/HP_0031024', 'lbl': 'Cylindroma', 'desc': 'label: Cylindroma\ndefinition : A benign skin adnexal tumor of eccrine differentiation.\nsynonyms :\n'}


{'id': 'HP_0031025', 'url': 'http://purl.obolibrary.org/obo/HP_0031025', 'lbl': 'Gastric leiomyosarcoma', 'desc': 'label: Gastric leiomyosarcoma\ndefinition : A malignant neoplasm of the stomach that grows submucosally in the gastric wall. Necrosis and hemorrhage may be visible radiologically. Histologically, spindle cells with abnormal mitotic activity may be visible.\nsynonyms :\n'}


{'id': 'HP_0031026', 'url': 'http://purl.obolibrary.org/obo/HP_0031026', 'lbl': 'Snail-like ilia', 'desc': 'label: Snail-like ilia\ndefinition : The ilia is round and hypoplastic with a very flat acetabular roof and a very unusual medial projection of bone that is said to resemble the head of a snail. Figure 4 of PMID:3799723 illustrates this feature.\nsynonyms :Snail-like pelvis; Snail-shaped ilia; Schneckenbecken dysplasia\n'}


{'id': 'HP_0031027', 'url': 'http://purl.obolibrary.org/obo/HP_0031027', 'lbl': 'Internal notch of the femoral head', 'desc': 'label: Internal notch of the femoral head\ndefinition : A small V-shaped indentation on the internal aspect of the femoral head. This feature is well illustrated in Figure 5 of PMID:11694546.\nsynonyms :\n'}


{'id': 'HP_0031028', 'url': 'http://purl.obolibrary.org/obo/HP_0031028', 'lbl': 'Lactescent serum', 'desc': 'label: Lactescent serum\ndefinition : Serum sample with a grossly white (milk-like, i.e., lactescent) appearance. This feature is indicative of an extremely elevated serum triglyceride level.\nsynonyms :Milk-like serum; Plasma lactescence\n'}


{'id': 'HP_0031029', 'url': 'http://purl.obolibrary.org/obo/HP_0031029', 'lbl': 'Elevated carcinoembryonic antigen level', 'desc': 'label: Elevated carcinoembryonic antigen level\ndefinition : An increased blood concentration of the carcinoembryonic antigen (CEA). CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker.\nsynonyms :Increased plasma CEA\n'}


{'id': 'HP_0031030', 'url': 'http://purl.obolibrary.org/obo/HP_0031030', 'lbl': 'Elevated carcinoma antigen 125 level', 'desc': 'label: Elevated carcinoma antigen 125 level\ndefinition : An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer.\nsynonyms :Increased plasma CA125\n'}


{'id': 'HP_0031031', 'url': 'http://purl.obolibrary.org/obo/HP_0031031', 'lbl': 'Abnormal retinol-binding protein level', 'desc': 'label: Abnormal retinol-binding protein level\ndefinition : A deviation from normal blood concentration of retinol-binding protein (RBP). The most commonly used indicator of vitamin A status is the serum retinol concentration (retinol is one of the several compounds known as vitamin A). The serum RBP concentration is used as a surrogate measure for serum retinol.\nsynonyms :\n'}


{'id': 'HP_0031032', 'url': 'http://purl.obolibrary.org/obo/HP_0031032', 'lbl': 'Decreased retinol-binding protein level', 'desc': 'label: Decreased retinol-binding protein level\ndefinition : A reduced blood concentration of retinol-binding protein. This finding predicts vitamin A deficiency with high sensitivity and specificity.\nsynonyms :\n'}


{'id': 'HP_0031033', 'url': 'http://purl.obolibrary.org/obo/HP_0031033', 'lbl': 'Impaired urinary acidification', 'desc': 'label: Impaired urinary acidification\ndefinition : The kidney contributes towards acid-base homeostasis by excreting H+ ions and retaining bicarbonate. This process is known as acidification of the urine. The pH of urine ranges normally from 4.5 to 8. The inability to reduce the pH of the urine in a situation where it would be otherwise expected is known as an acidification defect.\nsynonyms :Renal acidification defect\n'}


{'id': 'HP_0031034', 'url': 'http://purl.obolibrary.org/obo/HP_0031034', 'lbl': 'Abnormal insulin like growth factor binding protein acid labile subunit level', 'desc': 'label: Abnormal insulin like growth factor binding protein acid labile subunit level\ndefinition : A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier.\nsynonyms :\n'}


{'id': 'HP_0031035', 'url': 'http://purl.obolibrary.org/obo/HP_0031035', 'lbl': 'Chronic infection', 'desc': 'label: Chronic infection\ndefinition : Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.\nsynonyms :\n'}


{'id': 'HP_0031036', 'url': 'http://purl.obolibrary.org/obo/HP_0031036', 'lbl': 'Reduced growth-hormone binding protein level', 'desc': 'label: Reduced growth-hormone binding protein level\ndefinition : A decreased blood concentration of growth hormone binding protein.\nsynonyms :Decreased plasma GH-binding protein\n'}


{'id': 'HP_0031037', 'url': 'http://purl.obolibrary.org/obo/HP_0031037', 'lbl': 'Reduced insulin-like factor 3 level', 'desc': 'label: Reduced insulin-like factor 3 level\ndefinition : Blood concentration of insulin-like factor 3 (ILF3) is below normal limits.\nsynonyms :Reduced plasma INSL3 level\n'}


{'id': 'HP_0031038', 'url': 'http://purl.obolibrary.org/obo/HP_0031038', 'lbl': 'Spermatogenesis maturation arrest', 'desc': 'label: Spermatogenesis maturation arrest\ndefinition : Maturation arrest (MA) is defined as germ cells that fail to complete maturation. Uniform MA is characterized by spermatogenic arrest at the same stage of spermatogenesis throughout the seminiferous tubules. MA is subcategorized into early MA, in which only spermatogonia or spermatocytes are found, and late MA, in which spermatids are detected without spermatozoa.\nsynonyms :Meiotic maturation arrest of spermatogenesis\n'}


{'id': 'HP_0031039', 'url': 'http://purl.obolibrary.org/obo/HP_0031039', 'lbl': 'Early spermatogenesis maturation arrest', 'desc': 'label: Early spermatogenesis maturation arrest\ndefinition : A type of maturation arrest in which only spermatogonia or spermatocytes are found.\nsynonyms :Spermatocytic arrest\n'}


{'id': 'HP_0031040', 'url': 'http://purl.obolibrary.org/obo/HP_0031040', 'lbl': 'Late spermatogenesis maturation arrest', 'desc': 'label: Late spermatogenesis maturation arrest\ndefinition : A type of maturation arrest in which spermatids are detected without spermatozoa.\nsynonyms :Maturation arrest of spermatogenesis at spermatid stage\n'}


{'id': 'HP_0031041', 'url': 'http://purl.obolibrary.org/obo/HP_0031041', 'lbl': 'Obstruction of the superior vena cava', 'desc': 'label: Obstruction of the superior vena cava\ndefinition : Blockage of blood flow through the superior vena cava (SVC). Because the venous drainage from the upper extremities, upper thorax and head is obstructed, SVC obstruction presents with symptoms related to engorgement of these areas. Both the degree of SVC compromise and the extent of collateral veins determine the varied clinical presentation, which can be as mild as slight facial and upper extremity edema or as dire as intracranial swelling, seizures, hemodynamic instability and tracheal obstruction.\nsynonyms :Superior vena cava obstruction; Superior vena cava syndrome\n'}


{'id': 'HP_0031042', 'url': 'http://purl.obolibrary.org/obo/HP_0031042', 'lbl': 'Strawberry tongue', 'desc': 'label: Strawberry tongue\ndefinition : Inflammed tongue with hyperplastic (enlarged) fungiform papillae that is said to resemble a strawberry or raspberry.\nsynonyms :Raspberry tongue\n'}


{'id': 'HP_0031043', 'url': 'http://purl.obolibrary.org/obo/HP_0031043', 'lbl': 'Type A4 brachydactyly', 'desc': 'label: Type A4 brachydactyly\ndefinition : A type of brachydactyly characterized by brachymesophalangy affecting mainly the 2nd and 5th digits.\nsynonyms :\n'}


{'id': 'HP_0031044', 'url': 'http://purl.obolibrary.org/obo/HP_0031044', 'lbl': 'Type A5 brachydactyly', 'desc': 'label: Type A5 brachydactyly\ndefinition : A type of brachydactyly characterized by absent middle phalanges of digits 2 to 5.\nsynonyms :\n'}


{'id': 'HP_0031045', 'url': 'http://purl.obolibrary.org/obo/HP_0031045', 'lbl': 'Acral blistering', 'desc': 'label: Acral blistering\ndefinition : Bullae (defined as fluid-filled blisters more than 5 mm in diameter with thin walls) of the skin with an acral distribution (affecting peripheral regions such as hands and feet).\nsynonyms :\n'}


{'id': 'HP_0031046', 'url': 'http://purl.obolibrary.org/obo/HP_0031046', 'lbl': 'Absent soft palate', 'desc': 'label: Absent soft palate\ndefinition : A developmental defect characterized by lack of a soft palate.\nsynonyms :Agenesis of the soft palate\n'}


{'id': 'HP_0031047', 'url': 'http://purl.obolibrary.org/obo/HP_0031047', 'lbl': 'Paraproteinemia', 'desc': 'label: Paraproteinemia\ndefinition : An abnormal immunoglobulin or part of an Ig (light chain) in the circulation. Paraproteins are typically produced by a clonal population of B-cell derived plasma cells.\nsynonyms :Monoclonal hypergammaglobulinemia\n'}


{'id': 'HP_0031048', 'url': 'http://purl.obolibrary.org/obo/HP_0031048', 'lbl': 'Light-chain paraproteinemia', 'desc': 'label: Light-chain paraproteinemia\ndefinition : An abnormal immunoglobulin light chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.\nsynonyms :\n'}


{'id': 'HP_0031049', 'url': 'http://purl.obolibrary.org/obo/HP_0031049', 'lbl': 'Heavy-chain paraproteinemia', 'desc': 'label: Heavy-chain paraproteinemia\ndefinition : An abnormal immunoglobulin heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.\nsynonyms :\n'}


{'id': 'HP_0031050', 'url': 'http://purl.obolibrary.org/obo/HP_0031050', 'lbl': 'Whole-immunoglobulin paraproteinemia', 'desc': 'label: Whole-immunoglobulin paraproteinemia\ndefinition : An abnormal immunoglobulin (heavy and light chain) in the circulation and typically produced by a clonal population of B-cell derived plasma cells.\nsynonyms :\n'}


{'id': 'HP_0031051', 'url': 'http://purl.obolibrary.org/obo/HP_0031051', 'lbl': 'Tarsal sclerosis', 'desc': 'label: Tarsal sclerosis\ndefinition : An elevation in bone density in one or more tarsal bones of the foot. Sclerosis is normally detected on a radiograph as an area of increased opacity.\nsynonyms :\n'}


{'id': 'HP_0031052', 'url': 'http://purl.obolibrary.org/obo/HP_0031052', 'lbl': 'Elevated vascular endothelial growth factor level', 'desc': 'label: Elevated vascular endothelial growth factor level\ndefinition : Increased blood concentration of vascular endothelial growth factor (VEGF).\nsynonyms :Elevated circulating VEGF concentration\n'}


{'id': 'HP_0031053', 'url': 'http://purl.obolibrary.org/obo/HP_0031053', 'lbl': 'Coarctation in the transverse aortic arch', 'desc': 'label: Coarctation in the transverse aortic arch\ndefinition : Narrowing or constriction of the aorta localized to the region of the transverse aortic arch.\nsynonyms :\n'}


{'id': 'HP_0031054', 'url': 'http://purl.obolibrary.org/obo/HP_0031054', 'lbl': 'Long segment coarctation of the aorta', 'desc': 'label: Long segment coarctation of the aorta\ndefinition : Coarctation of the aorta is a narrowing or constriction of a long segment of the arch of the aorta.\nsynonyms :\n'}


{'id': 'HP_0031055', 'url': 'http://purl.obolibrary.org/obo/HP_0031055', 'lbl': 'Abnormal branching pattern of left aortic arch', 'desc': 'label: Abnormal branching pattern of left aortic arch\ndefinition : A deviance from the norm of the origin or course of the right brachiocephalic artery, the left common carotid artery, the left subclavian artery or the proximal vertebral arteries, whereby the aortic arch descends on the left as normal (as opposed to right aortic arch).\nsynonyms :\n'}


{'id': 'HP_0031056', 'url': 'http://purl.obolibrary.org/obo/HP_0031056', 'lbl': 'Fusiform cerebral aneurysm', 'desc': 'label: Fusiform cerebral aneurysm\ndefinition : A localized circumferential (i.e., bulges on all sides) dilatation or ballooning of a cerebral artery.\nsynonyms :Intracranial fusiform aneurysm\n'}


{'id': 'HP_0031057', 'url': 'http://purl.obolibrary.org/obo/HP_0031057', 'lbl': 'Skin fissure', 'desc': 'label: Skin fissure\ndefinition : A clearly-defined and roughly linear cleavage in the skin that usually extends to the dermis.\nsynonyms :Cracked skin\n'}


{'id': 'HP_0031058', 'url': 'http://purl.obolibrary.org/obo/HP_0031058', 'lbl': 'Impairment of activities of daily living', 'desc': 'label: Impairment of activities of daily living\ndefinition : Difficulty in performing one or more activities normally performed every day, such as eating, bathing, dressing, grooming, work, homemaking, and leisure.\nsynonyms :\n'}


{'id': 'HP_0031059', 'url': 'http://purl.obolibrary.org/obo/HP_0031059', 'lbl': 'Impaired ability to bathe oneself', 'desc': 'label: Impaired ability to bathe oneself\ndefinition : This term applies to an individual who requires help to bathe more than one part of the body, get in or out of the tub or shower, or who requires total bathing.\nsynonyms :\n'}


{'id': 'HP_0031060', 'url': 'http://purl.obolibrary.org/obo/HP_0031060', 'lbl': 'Impaired ability to dress oneself', 'desc': 'label: Impaired ability to dress oneself\ndefinition : This applies to an individual who needs help with dressing or needs to be completely dressed.\nsynonyms :\n'}


{'id': 'HP_0031061', 'url': 'http://purl.obolibrary.org/obo/HP_0031061', 'lbl': 'Impaired toileting ability', 'desc': 'label: Impaired toileting ability\ndefinition : This term applies to an individual who requires help transferring to the toilet, cleaning self or who uses bedpan or commode.\nsynonyms :\n'}


{'id': 'HP_0031062', 'url': 'http://purl.obolibrary.org/obo/HP_0031062', 'lbl': 'Impaired transferring ability', 'desc': 'label: Impaired transferring ability\ndefinition : Applies to an individual who needs help in moving from bed to chair or requires a complete transfer.\nsynonyms :\n'}


{'id': 'HP_0031063', 'url': 'http://purl.obolibrary.org/obo/HP_0031063', 'lbl': 'Impaired feeding ability', 'desc': 'label: Impaired feeding ability\ndefinition : Applies to an individual who needs partial or total help with feeding or requires parenteral feeding.\nsynonyms :\n'}


{'id': 'HP_0031064', 'url': 'http://purl.obolibrary.org/obo/HP_0031064', 'lbl': 'Impaired continence', 'desc': 'label: Impaired continence\ndefinition : Partial or total incontinence of bowel or bladder.\nsynonyms :\n'}


{'id': 'HP_0031065', 'url': 'http://purl.obolibrary.org/obo/HP_0031065', 'lbl': 'Abnormal ovarian morphology', 'desc': 'label: Abnormal ovarian morphology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031066', 'url': 'http://purl.obolibrary.org/obo/HP_0031066', 'lbl': 'Abnormal ovarian physiology', 'desc': 'label: Abnormal ovarian physiology\ndefinition : Any anomaly of ovarian function.\nsynonyms :\n'}


{'id': 'HP_0031067', 'url': 'http://purl.obolibrary.org/obo/HP_0031067', 'lbl': 'Empty ovarian follicle', 'desc': 'label: Empty ovarian follicle\ndefinition : A failure to collect oocytes after an apparently normal controlled ovarian hyperstimulation cycle for in vitro fertilization.\nsynonyms :Empty follicle syndrome\n'}


{'id': 'HP_0031068', 'url': 'http://purl.obolibrary.org/obo/HP_0031068', 'lbl': 'obsolete Increased femoral torsion', 'desc': 'label: obsolete Increased femoral torsion\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031069', 'url': 'http://purl.obolibrary.org/obo/HP_0031069', 'lbl': 'Abnormal femoral torsion', 'desc': 'label: Abnormal femoral torsion\ndefinition : Femoral torsion, also known as femoral rotation or femoral version, refers to the twist between the proximal and distal parts of the femur on the transverse plane. Femoral anteversion averages between 30-40 degress at birth, and between 8-14 degrees in adults. This term applies if the amount of femoral torsion deviates from this range.\nsynonyms :\n'}


{'id': 'HP_0031070', 'url': 'http://purl.obolibrary.org/obo/HP_0031070', 'lbl': 'obsolete Femoral retroversion', 'desc': 'label: obsolete Femoral retroversion\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031071', 'url': 'http://purl.obolibrary.org/obo/HP_0031071', 'lbl': 'Abnormal endocrine morphology', 'desc': 'label: Abnormal endocrine morphology\ndefinition : Any anomaly of the structure of an organ ofthe endocrine system.\nsynonyms :\n'}


{'id': 'HP_0031072', 'url': 'http://purl.obolibrary.org/obo/HP_0031072', 'lbl': 'Abnormal endocrine physiology', 'desc': 'label: Abnormal endocrine physiology\ndefinition : Any anomaly of the function of the endocrine system.\nsynonyms :\n'}


{'id': 'HP_0031073', 'url': 'http://purl.obolibrary.org/obo/HP_0031073', 'lbl': 'Abnormal response to endocrine stimulation test', 'desc': 'label: Abnormal response to endocrine stimulation test\ndefinition : An anomalous response to a test that is designed to probe the function of the endocrine system.\nsynonyms :\n'}


{'id': 'HP_0031074', 'url': 'http://purl.obolibrary.org/obo/HP_0031074', 'lbl': 'Abnormal response to ACTH stimulation test', 'desc': 'label: Abnormal response to ACTH stimulation test\ndefinition : An anomolous response to stimulation by adminstration of the adrenocorticotropic hormone (ACTH). ACTH stimulation normally stimulates the adrenal glands to release cortisol and adrenaline.\nsynonyms :Abnormal response to adrenocorticotropic-hormone stimulation test; Abnormal response to corticotropin stimulation test\n'}


{'id': 'HP_0031075', 'url': 'http://purl.obolibrary.org/obo/HP_0031075', 'lbl': 'Abnormal response to insulin tolerance test', 'desc': 'label: Abnormal response to insulin tolerance test\ndefinition : An anomalous response to the insulin tolerance test (ITT), in which insulin is administered intravenously and blood glucose and potentially other compounds are measured at intervals. Insulin administration is intended to induce extreme hypoglycemia (bloodgluoce below 40 mg/dl), which in turn induces release of adrenocorticotropic hormone (ACTH) and growth hormone (GH). ACTH induces the adrenal gland to release cortisol, which together with GH opposes the action of insulin on the blood glucose level.\nsynonyms :\n'}


{'id': 'HP_0031076', 'url': 'http://purl.obolibrary.org/obo/HP_0031076', 'lbl': 'Impaired cortisol response to insulin stimulation test', 'desc': 'label: Impaired cortisol response to insulin stimulation test\ndefinition : Failure of cortisol levels to respond adequately (by increasing) to the insulin tolerance test (ITT).\nsynonyms :\n'}


{'id': 'HP_0031077', 'url': 'http://purl.obolibrary.org/obo/HP_0031077', 'lbl': 'Abnormal response to corticotropin releasing hormone stimulation test', 'desc': 'label: Abnormal response to corticotropin releasing hormone stimulation test\ndefinition : An anomalous response to the corticotropin releasing hormone (CRH) stimulation test. Normally,CRH is released by the hypothalamus to induce adrenocorticotropic hormone (ACTH) release by the anterior pituitary. In the stimulation test, CRH is administered intravenously and ACTH and cortisol are measured at intervals.\nsynonyms :Abnormal response to CRH stimulation test\n'}


{'id': 'HP_0031078', 'url': 'http://purl.obolibrary.org/obo/HP_0031078', 'lbl': 'Impaired cortisol response to corticotropin releasing hormone stimulation test', 'desc': 'label: Impaired cortisol response to corticotropin releasing hormone stimulation test\ndefinition : Failure of cortisol levels to respond adequately (by increasing) to the corticotropin releasing hormone stimulation test.\nsynonyms :\n'}


{'id': 'HP_0031079', 'url': 'http://purl.obolibrary.org/obo/HP_0031079', 'lbl': 'Impaired growth-hormone response to insulin stimulation test', 'desc': 'label: Impaired growth-hormone response to insulin stimulation test\ndefinition : Failure of growth hormone levels to respond adequately (by increasing) to the insulin tolerance test (ITT).\nsynonyms :\n'}


{'id': 'HP_0031080', 'url': 'http://purl.obolibrary.org/obo/HP_0031080', 'lbl': 'Abnormal response to glucagon stimulation test', 'desc': 'label: Abnormal response to glucagon stimulation test\ndefinition : An anomalous response to the glucagon stimulation test, which like the insulin tolerance test (ITT) stimulates the release of both adrenocorticotropic hormone (ACTH) and growth hormone (GH).\nsynonyms :\n'}


{'id': 'HP_0031081', 'url': 'http://purl.obolibrary.org/obo/HP_0031081', 'lbl': 'Impaired cortisol response to glucagon stimulation test', 'desc': 'label: Impaired cortisol response to glucagon stimulation test\ndefinition : Failure of cortisol levels to respond adequately (by increasing) to the glucagon stimulation test.\nsynonyms :\n'}


{'id': 'HP_0031082', 'url': 'http://purl.obolibrary.org/obo/HP_0031082', 'lbl': 'Impaired growth-hormone response to glucagon stimulation test', 'desc': 'label: Impaired growth-hormone response to glucagon stimulation test\ndefinition : Failure of growth hormone levels to respond adequately (by increasing) to the glucagon stimulation test.\nsynonyms :\n'}


{'id': 'HP_0031083', 'url': 'http://purl.obolibrary.org/obo/HP_0031083', 'lbl': 'Abnormal response to human chorionic gonadotrophin stimulation test', 'desc': 'label: Abnormal response to human chorionic gonadotrophin stimulation test\ndefinition : An anomalous response to intravenous stimulation by human chorionic gonadotrophin. Stimulation with hCG stimulates testicular Leydig cells to secrete androgens via the Leydig hormone receptors.\nsynonyms :Abnormal response to hCG stimulation test\n'}


{'id': 'HP_0031084', 'url': 'http://purl.obolibrary.org/obo/HP_0031084', 'lbl': 'Excessive insulin response to glucagon test', 'desc': 'label: Excessive insulin response to glucagon test\ndefinition : An abnormally high increase in insulin levels following a glucagon stimulation test.\nsynonyms :\n'}


{'id': 'HP_0031085', 'url': 'http://purl.obolibrary.org/obo/HP_0031085', 'lbl': 'Decreased prealbumin level', 'desc': 'label: Decreased prealbumin level\ndefinition : A reduced concentration of prealbumin in the blood. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status.\nsynonyms :\n'}


{'id': 'HP_0031086', 'url': 'http://purl.obolibrary.org/obo/HP_0031086', 'lbl': 'Ectopic ovary', 'desc': 'label: Ectopic ovary\ndefinition : Undescended or ectopic ovaries are characterized by the attachment of the upper pole of the ovary to an area above the level of the common iliac vessels.\nsynonyms :Undescended ovary\n'}


{'id': 'HP_0031087', 'url': 'http://purl.obolibrary.org/obo/HP_0031087', 'lbl': 'Absent pubertal growth spurt', 'desc': 'label: Absent pubertal growth spurt\ndefinition : The abrupt and transient increase in the annual growth rate normally observed in adolescent individuals does not occur.\nsynonyms :Absent adolescent growth spurt\n'}


{'id': 'HP_0031088', 'url': 'http://purl.obolibrary.org/obo/HP_0031088', 'lbl': 'Vaginal dryness', 'desc': 'label: Vaginal dryness\ndefinition : Persistent vaginal dryness.\nsynonyms :\n'}


{'id': 'HP_0031089', 'url': 'http://purl.obolibrary.org/obo/HP_0031089', 'lbl': 'Palatal edema', 'desc': 'label: Palatal edema\ndefinition : Swelling related to fluid accumulation within the palate.\nsynonyms :Palatal oedema; Palate edema; Palate oedema\n'}


{'id': 'HP_0031090', 'url': 'http://purl.obolibrary.org/obo/HP_0031090', 'lbl': 'Finger dactylitis', 'desc': 'label: Finger dactylitis\ndefinition : Fingers appear swollen and plump owing to inflammation of the complete finger.\nsynonyms :Sausage fingers\n'}


{'id': 'HP_0031091', 'url': 'http://purl.obolibrary.org/obo/HP_0031091', 'lbl': 'Toe dactylitis', 'desc': 'label: Toe dactylitis\ndefinition : Toes appear swollen and plump owing to inflammation of the complete toe.\nsynonyms :Sausage toes\n'}


{'id': 'HP_0031092', 'url': 'http://purl.obolibrary.org/obo/HP_0031092', 'lbl': 'Spindle-shaped finger', 'desc': 'label: Spindle-shaped finger\ndefinition : Swelling of the hand at the knuckles, that gives the fingers a spindle shape (i.e., a round stick with tapered end and a broader base).\nsynonyms :\n'}


{'id': 'HP_0031093', 'url': 'http://purl.obolibrary.org/obo/HP_0031093', 'lbl': 'Abnormal breast morphology', 'desc': 'label: Abnormal breast morphology\ndefinition : Any anomaly of the structure of the breast.\nsynonyms :\n'}


{'id': 'HP_0031094', 'url': 'http://purl.obolibrary.org/obo/HP_0031094', 'lbl': 'Abnormal breast physiology', 'desc': 'label: Abnormal breast physiology\ndefinition : Any anomaly of the function of the breast.\nsynonyms :\n'}


{'id': 'HP_0031095', 'url': 'http://purl.obolibrary.org/obo/HP_0031095', 'lbl': 'Abnormal humerus morphology', 'desc': 'label: Abnormal humerus morphology\ndefinition : Any anomaly of the structure of the humerus.\nsynonyms :\n'}


{'id': 'HP_0031096', 'url': 'http://purl.obolibrary.org/obo/HP_0031096', 'lbl': 'Delayed vertebral ossification', 'desc': 'label: Delayed vertebral ossification\ndefinition : A decrease in the amount of mineralized bone in one or more vertebrae compared with that expected for a given developmental age.\nsynonyms :\n'}


{'id': 'HP_0031097', 'url': 'http://purl.obolibrary.org/obo/HP_0031097', 'lbl': 'Abnormal thyroid-stimulating hormone level', 'desc': 'label: Abnormal thyroid-stimulating hormone level\ndefinition : Any deviation from the normal amount of the thyroid-stimulating hormone (TSH), which is produced by the anterior pituitary gland and stimulates the function of the thyroid gland.\nsynonyms :Abnormal TSH level; Abnormal circulating thyrotropin concentration; Abnormal thyrotropin level\n'}


{'id': 'HP_0031098', 'url': 'http://purl.obolibrary.org/obo/HP_0031098', 'lbl': 'Decreased thyroid-stimulating hormone level', 'desc': 'label: Decreased thyroid-stimulating hormone level\ndefinition : Reduced amount of the thyroid-stimulating hormone (TSH), which is produced by the anterior pituitary gland and stimulates the function of the thyroid gland.\nsynonyms :Decreased plasma TSH; Decreased thyrotropin level\n'}


{'id': 'HP_0031099', 'url': 'http://purl.obolibrary.org/obo/HP_0031099', 'lbl': 'Abnormal circulating inhibin level', 'desc': 'label: Abnormal circulating inhibin level\ndefinition : Any deviation from the normal concentration of inhibins, which are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins suppress the secretion of pituitary follicle-stimulating hormone.\nsynonyms :\n'}


{'id': 'HP_0031100', 'url': 'http://purl.obolibrary.org/obo/HP_0031100', 'lbl': 'Decreased inhibin B level', 'desc': 'label: Decreased inhibin B level\ndefinition : A reduced concentration of inhibin B in the blood.\nsynonyms :\n'}


{'id': 'HP_0031101', 'url': 'http://purl.obolibrary.org/obo/HP_0031101', 'lbl': 'Abnormal circulating antimullerian hormone concentration', 'desc': 'label: Abnormal circulating antimullerian hormone concentration\ndefinition : Any deviation from the normal range of the antimullerian hormone, a peptide produced by the granulosa cells of follicles. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is produced by the granulosa cells of small antral follicles of the ovary. AMH has an inhibiting role in the ovary, contributing to follicular arrest. AMH levels in women are low until the age of 8, rise rapidly until puberty and decline steadily from the age of 25 until menopause, when AMH production ceases.\nsynonyms :Abnormal antimullerian hormone level\n'}


{'id': 'HP_0031102', 'url': 'http://purl.obolibrary.org/obo/HP_0031102', 'lbl': 'Increased circulating antimullerian hormone concentration', 'desc': 'label: Increased circulating antimullerian hormone concentration\ndefinition : An elevation above the normal range of the antimullerian hormone in the circulation.\nsynonyms :Increased antimullerian hormone level; Increased plasma AMH\n'}


{'id': 'HP_0031103', 'url': 'http://purl.obolibrary.org/obo/HP_0031103', 'lbl': 'Decreased cirrculating antimullerian hormone circulation', 'desc': 'label: Decreased cirrculating antimullerian hormone circulation\ndefinition : A reduction below the normal range of the antimullerian hormone in the circulation.\nsynonyms :Anti-Mullerian hormone low; Decreased antimullerian hormone level; Decreased plasma AMH\n'}


{'id': 'HP_0031104', 'url': 'http://purl.obolibrary.org/obo/HP_0031104', 'lbl': 'Insulin receptor antibody positivity', 'desc': 'label: Insulin receptor antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react against the insulin receptor.\nsynonyms :\n'}


{'id': 'HP_0031105', 'url': 'http://purl.obolibrary.org/obo/HP_0031105', 'lbl': 'Abnormal uterus morphology', 'desc': 'label: Abnormal uterus morphology\ndefinition : Any anomaly of the structure of the uterus\nsynonyms :\n'}


{'id': 'HP_0031106', 'url': 'http://purl.obolibrary.org/obo/HP_0031106', 'lbl': 'T-shaped uterus', 'desc': 'label: T-shaped uterus\ndefinition : An abnormality of the uterus characterized by a normal uterine outline but with an abnormal T-shaped uterine cavity with narrowing cavity due to thickened lateral walls with a correlation 2/3 uterine corpus and 1/3 cervix. The abnormlaity is said to resemble the letter T in hysterosalpingographic imaging.\nsynonyms :\n'}


{'id': 'HP_0031107', 'url': 'http://purl.obolibrary.org/obo/HP_0031107', 'lbl': 'Decreased fibular diameter', 'desc': 'label: Decreased fibular diameter\ndefinition : Reduced width of the cross sectional diameter of the fibula.\nsynonyms :Thin fibula\n'}


{'id': 'HP_0031108', 'url': 'http://purl.obolibrary.org/obo/HP_0031108', 'lbl': 'Triceps weakness', 'desc': 'label: Triceps weakness\ndefinition : A lack of strength in the triceps muscle, which normally is responsible for extending (straightening) the elbow and mediating certain shoulder movements.\nsynonyms :\n'}


{'id': 'HP_0031109', 'url': 'http://purl.obolibrary.org/obo/HP_0031109', 'lbl': 'Agalactia', 'desc': 'label: Agalactia\ndefinition : Failure of secretion of milk following childbirth associated with an inability to breastfeed an infant.\nsynonyms :Lactation incapacity\n'}


{'id': 'HP_0031110', 'url': 'http://purl.obolibrary.org/obo/HP_0031110', 'lbl': 'Twin-to-twin transfusion', 'desc': "label: Twin-to-twin transfusion\ndefinition : As a result of sharing a single placenta, the blood supplies of monochorionic twin fetuses can become connected, so that they share blood circulation: although each fetus uses its own portion of the placenta, the connecting blood vessels within the placenta allow blood to pass from one twin to the other.Depending on the number, type and direction of the interconnecting blood vessels (anastomoses), blood can be transferred disproportionately from one twin (the donor) to the other (the recipient). This state of transfusion causes the donor twin to have decreased blood volume, retarding the donor's development and growth. The blood volume of the recipient twin is increased, which can strain the fetus's heart and eventually lead to heart failure.\nsynonyms :Twin to twin transfusion syndrome\n"}


{'id': 'HP_0031111', 'url': 'http://purl.obolibrary.org/obo/HP_0031111', 'lbl': 'Cutaneous hamartoma', 'desc': 'label: Cutaneous hamartoma\ndefinition : A hamartoma (tissue malformation consisting of an abnormal mixture of constitutive components) originating in the skin.\nsynonyms :Skin hamartoma\n'}


{'id': 'HP_0031117', 'url': 'http://purl.obolibrary.org/obo/HP_0031117', 'lbl': 'Purely bicuspid aortic valve', 'desc': 'label: Purely bicuspid aortic valve\ndefinition : A type of bicuspid aortic valve (BAV) characterized by two equal-sized cusps, with no raphe and only two commissures. There is a lateral arrangement of the free edge of the cusps. Note that this differs from some other forms of BAV in which there are three commissures and two of the three cusps are joined by a raphe forming two functional leaflets. This type of BAV often is associated with aortic stenosis.\nsynonyms :\n'}


{'id': 'HP_0031118', 'url': 'http://purl.obolibrary.org/obo/HP_0031118', 'lbl': 'Single raphe bicuspid aortic valve', 'desc': 'label: Single raphe bicuspid aortic valve\ndefinition : A type of bicuspid aortic valvue (BAV) characterized by the presence of a single raphe that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps, resulting in two leaflets of unequal size.\nsynonyms :\n'}


{'id': 'HP_0031119', 'url': 'http://purl.obolibrary.org/obo/HP_0031119', 'lbl': 'Bicuspid aortic valve with right-left cusp fusion', 'desc': 'label: Bicuspid aortic valve with right-left cusp fusion\ndefinition : A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and left cusps (RL fusion pattern). This results in two leaflefts with an anterior-posterior leaflet orientation (also called the typical pattern). There is thus one completely developed noncoronary cusp, two completely developed commissures, and one raphe between the underdeveloped left and right coronary cusps extending to the corresponding malformed commissure.\nsynonyms :\n'}


{'id': 'HP_0031120', 'url': 'http://purl.obolibrary.org/obo/HP_0031120', 'lbl': 'Bicuspid aortic valve with right-noncoronary cusp fusion', 'desc': 'label: Bicuspid aortic valve with right-noncoronary cusp fusion\ndefinition : A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and noncoronary cusps (RN fusion pattern). This results in two leaflets with right-left leaflet orientation (also called the atypical pattern). There is thus one completely developed left cusp, two completely developed commissures, and one raphe between the underdeveloped right and noncoronary coronary cusps extending to the corresponding malformed commissure.\nsynonyms :\n'}


{'id': 'HP_0031121', 'url': 'http://purl.obolibrary.org/obo/HP_0031121', 'lbl': 'Bicuspid aortic valve with left-noncoronary cusp fusion', 'desc': 'label: Bicuspid aortic valve with left-noncoronary cusp fusion\ndefinition : A type of bicuspid aortic valve (BAV) characterized by a single raphe between the left and noncoronary cusps (LN fusion pattern). There is thus one completely developed right cusp, two completely developed commissures, and one raphe between the underdeveloped left and noncoronary coronary cusps extending to the corresponding malformed commissure.\nsynonyms :\n'}


{'id': 'HP_0031122', 'url': 'http://purl.obolibrary.org/obo/HP_0031122', 'lbl': 'Two-raphe bicuspid aortic valve', 'desc': 'label: Two-raphe bicuspid aortic valve\ndefinition : A type of bicuspid aortic valvue (BAV) characterized by the presence of two raphes that each extend from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV has developmental anlagen of three cusps, commissures, and sinuses, but two commissures are more or less malformed and obliterated, giving rise to a raphe, a fibrous ridge, which extends from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV is typically associated with a high degree of aortic stenosis.\nsynonyms :\n'}


{'id': 'HP_0031123', 'url': 'http://purl.obolibrary.org/obo/HP_0031123', 'lbl': 'Recurrent gastroenteritis', 'desc': 'label: Recurrent gastroenteritis\ndefinition : Increased susceptibility to gastroenteritis, an infectious inflammationof the stomach and small intestines manifested by signs and symptoms such as diarheas and abdominal pain, as manifested by recurrent episodes of gastroenteritis.\nsynonyms :\n'}


{'id': 'HP_0031124', 'url': 'http://purl.obolibrary.org/obo/HP_0031124', 'lbl': 'Decreased platelet thromboxane A2 receptor', 'desc': 'label: Decreased platelet thromboxane A2 receptor\ndefinition : Decreased cell membrane concentration of thromboxane A2 receptor that is stimulated by thromboxane A2 (TBXA2).\nsynonyms :\n'}


{'id': 'HP_0031125', 'url': 'http://purl.obolibrary.org/obo/HP_0031125', 'lbl': 'Decreased platelet alpha-2A-adrenergic receptor', 'desc': 'label: Decreased platelet alpha-2A-adrenergic receptor\ndefinition : Decreased cell membrane concentration of alpha-2A adrenergic receptor that is stimulated by epinephrine.\nsynonyms :\n'}


{'id': 'HP_0031126', 'url': 'http://purl.obolibrary.org/obo/HP_0031126', 'lbl': 'Impaired clot retraction', 'desc': 'label: Impaired clot retraction\ndefinition : Platelets contain contractile proteins (actin and myosin) that induce clot retraction. As the platelets contract, they pull on the surrounding fibrin strands, squeezing serum form the mass, compacting the clot and drawing the ruptured edges of the blood vessel more closely together. Clot retraction is directly proportional to the platelet count and inversely proportional to the fibrinogen concentration.\nsynonyms :\n'}


{'id': 'HP_0031127', 'url': 'http://purl.obolibrary.org/obo/HP_0031127', 'lbl': 'Impaired convulxin-induced platelet aggregation', 'desc': 'label: Impaired convulxin-induced platelet aggregation\ndefinition : Abnormal response to convulxin as manifested by reduced or lacking aggregation of platelets upon addition of convulxin.\nsynonyms :\n'}


{'id': 'HP_0031128', 'url': 'http://purl.obolibrary.org/obo/HP_0031128', 'lbl': 'Impaired collagen-related peptide-induced platelet aggregation', 'desc': 'label: Impaired collagen-related peptide-induced platelet aggregation\ndefinition : Abnormal response to collagen-related peptide (CRP) as manifested by reduced or lacking aggregation of platelets upon addition of CRP.\nsynonyms :\n'}


{'id': 'HP_0031129', 'url': 'http://purl.obolibrary.org/obo/HP_0031129', 'lbl': 'Impaired phorbol myristate acetate-induced platelet aggregation', 'desc': 'label: Impaired phorbol myristate acetate-induced platelet aggregation\ndefinition : Abnormal response to phorbol myristate acetate (PMA) as manifested by reduced or lacking aggregation of platelets upon addition of PMA.\nsynonyms :\n'}


{'id': 'HP_0031130', 'url': 'http://purl.obolibrary.org/obo/HP_0031130', 'lbl': 'Impaired calcium ionophore-induced platelet aggregation', 'desc': 'label: Impaired calcium ionophore-induced platelet aggregation\ndefinition : Abnormal response to calcium Ionophore (such as A23187) as manifested by reduced or lacking aggregation of platelets upon addition of the ionophore.\nsynonyms :Impaired Ca ionophore-induced platelet aggregation; Impaired Ca2+ ionophore-induced platelet aggregation\n'}


{'id': 'HP_0031131', 'url': 'http://purl.obolibrary.org/obo/HP_0031131', 'lbl': 'Abnormal platelet phosphatidylserine exposure', 'desc': 'label: Abnormal platelet phosphatidylserine exposure\ndefinition : An abnormality of phosphatidylserine (PS) on activated platelets. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the plasma-oriented surface of discrete membrane vesicles that derive from activated platelets. Thrombin, the central molecule of coagulation, is produced from prothrombin by a complex (prothrombinase) between factor Xa and its protein cofactor (factor V(a)) that forms on platelet-derived membranes. This complex enhances the rate of activation of prothrombin to thrombin by roughly 150,000 fold relative to factor X(a) in solution. The negatively charged surface of PS-containing platelet-derived membranes is at least partly responsible for this rate enhancement.\nsynonyms :\n'}


{'id': 'HP_0031132', 'url': 'http://purl.obolibrary.org/obo/HP_0031132', 'lbl': 'Impaired annexin V binding to platelet phosphatidylserine', 'desc': 'label: Impaired annexin V binding to platelet phosphatidylserine\ndefinition : Reduced binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry.\nsynonyms :\n'}


{'id': 'HP_0031133', 'url': 'http://purl.obolibrary.org/obo/HP_0031133', 'lbl': 'Increased annexin V binding to platelet phosphatidylserine', 'desc': 'label: Increased annexin V binding to platelet phosphatidylserine\ndefinition : Elevated binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry.\nsynonyms :\n'}


{'id': 'HP_0031134', 'url': 'http://purl.obolibrary.org/obo/HP_0031134', 'lbl': 'Cor triatrium sinister', 'desc': 'label: Cor triatrium sinister\ndefinition : A developmental anomaly of the heart characterized by the presence of three atria because the left atrium is divided by an abnormal septum.\nsynonyms :\n'}


{'id': 'HP_0031135', 'url': 'http://purl.obolibrary.org/obo/HP_0031135', 'lbl': 'Triggered by physical trauma', 'desc': 'label: Triggered by physical trauma\ndefinition : Applies to a sign or symptom that is provoked or brought about by exposure to a trauma (injury to tissue).\nsynonyms :Physical trauma triggered symptoms\n'}


{'id': 'HP_0031136', 'url': 'http://purl.obolibrary.org/obo/HP_0031136', 'lbl': 'Decreased acrosin in sperm head', 'desc': 'label: Decreased acrosin in sperm head\ndefinition : A reduced amount of the enzyme acrosin in the sperm head acrosome. The acrosome is an organelle in the anterior half of the head of spermatozoa, and acrosin is a protease that contributes to the digestation of the zona pellucida in the fertilization process.\nsynonyms :\n'}


{'id': 'HP_0031137', 'url': 'http://purl.obolibrary.org/obo/HP_0031137', 'lbl': 'Storage in hepatocytes', 'desc': 'label: Storage in hepatocytes\ndefinition : Hepatocytes (liver parenchymal cells) exhibit a bloated appearance because of expansion of the cytoplasm by accumulated material.\nsynonyms :\n'}


{'id': 'HP_0031138', 'url': 'http://purl.obolibrary.org/obo/HP_0031138', 'lbl': 'Abnormal B-type natriuretic peptide concentration', 'desc': 'label: Abnormal B-type natriuretic peptide concentration\ndefinition : A deviation from the normal circulating concentration of B-type natriuretic peptide (BNP).\nsynonyms :Abnormal B-type natriuretic peptide level\n'}


{'id': 'HP_0031139', 'url': 'http://purl.obolibrary.org/obo/HP_0031139', 'lbl': 'Frog-leg posture', 'desc': 'label: Frog-leg posture\ndefinition : A type of rest posture in an infant that indicated a generalized reduction in muscle tone. The hips are flexed and the legs are abducted to an extent that causes the lateral thigh to rest upon the supporting surface. This posture is said to resemble the legs of a frog.\nsynonyms :\n'}


{'id': 'HP_0031140', 'url': 'http://purl.obolibrary.org/obo/HP_0031140', 'lbl': 'Abnormal liver sonography', 'desc': 'label: Abnormal liver sonography\ndefinition : An abnormal appearance of the liver or any of its components on sonography (ultrasound).\nsynonyms :\n'}


{'id': 'HP_0031141', 'url': 'http://purl.obolibrary.org/obo/HP_0031141', 'lbl': 'Increased hepatic echogenicity', 'desc': 'label: Increased hepatic echogenicity\ndefinition : Increased echogenicity of liver tissue on sonography, manifested as an increased amount of white on the screen of the sonography device.\nsynonyms :Hyperechogenic liver\n'}


{'id': 'HP_0031142', 'url': 'http://purl.obolibrary.org/obo/HP_0031142', 'lbl': 'Abnormal hepatic echogenicity', 'desc': 'label: Abnormal hepatic echogenicity\ndefinition : Any deviation from the normal degree of echogenicity of the liver on sonography. Echogenicity refers to the ability of a tissue to reflect or transmit ultrasound waves in the context of surrounding tissues. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. Based on echogenicity, a structure can be characterized as hyperechoic (white on the screen), hypoechoic (gray on the screen) and anechoic (black on the screen).\nsynonyms :\n'}


{'id': 'HP_0031143', 'url': 'http://purl.obolibrary.org/obo/HP_0031143', 'lbl': 'Decreased hepatic echogenicity', 'desc': 'label: Decreased hepatic echogenicity\ndefinition : Reduced echogenicity of liver tissue on sonography, manifested as an increased amount of black on the screen of the sonography device.\nsynonyms :Hypoechogenic liver\n'}


{'id': 'HP_0031144', 'url': 'http://purl.obolibrary.org/obo/HP_0031144', 'lbl': 'Coarsened hepatic echotexture', 'desc': 'label: Coarsened hepatic echotexture\ndefinition : The appearance of the liver in sonographic images is normally uniform. This term applies when there is an irregular or non-uniform appearance of the liver parenchyma in liver sonography.\nsynonyms :\n'}


{'id': 'HP_0031145', 'url': 'http://purl.obolibrary.org/obo/HP_0031145', 'lbl': 'Starry sky appearance on hepatic sonography', 'desc': 'label: Starry sky appearance on hepatic sonography\ndefinition : An abnormal echotexture visible in liver ultrasound manifesting as a diffuse hyperechoic liver echotexture with multiple, small hypoechoic lesions. The appearance is said to resemble a starry sky (multiple white spots on a dark background).\nsynonyms :\n'}


{'id': 'HP_0031146', 'url': 'http://purl.obolibrary.org/obo/HP_0031146', 'lbl': 'Impaired oral bolus formation', 'desc': 'label: Impaired oral bolus formation\ndefinition : An abnormality of swallowing characterized by reduced tongue coordination to form bolus after chewing. Food material spreads over the oral cavity instead of being concentrated into a bolus that is easily swallowed.\nsynonyms :\n'}


{'id': 'HP_0031150', 'url': 'http://purl.obolibrary.org/obo/HP_0031150', 'lbl': 'Vitreomacular adhesion', 'desc': 'label: Vitreomacular adhesion\ndefinition : Perifoveal vitreous separation with remaining vitreomacular attachment and unperturbed foveal morphologic features. It is an OCT finding that is almost always the result of normal vitreous aging, which may lead to pathologic conditions.\nsynonyms :VMA\n'}


{'id': 'HP_0031151', 'url': 'http://purl.obolibrary.org/obo/HP_0031151', 'lbl': 'Vitreomacular traction', 'desc': 'label: Vitreomacular traction\ndefinition : Vitreomacular traction is characterized by anomalous posterior vitreous detachment accompanied by anatomic distortion of the fovea, which may include pseudocysts, macular schisis, cystoid macular edema, and subretinal fluid. Vitreomacular traction can be subclassified by the diameter of vitreous attachment to the macular surface as measured by OCT, with attachment of 1500 micrometers or less defined as focal and attachment of more than 1500 micrometers as broad.\nsynonyms :VMT\n'}


{'id': 'HP_0031152', 'url': 'http://purl.obolibrary.org/obo/HP_0031152', 'lbl': 'Full-thickness macular hole', 'desc': 'label: Full-thickness macular hole\ndefinition : Full-thickness macular hole (FTMH) is defined as a foveal lesion with interruption of all retinal layers from the internal limiting membrane to the retinal pigment epithelium. Full-thickness macular hole is primary if caused by vitreous traction or secondary if directly the result of pathologic characteristics other than vitreomacular traction. Full-thickness macular hole is subclassified by size of the hole as determined by OCT and the presence or absence of vitreomacular traction.\nsynonyms :FTMH\n'}


{'id': 'HP_0031153', 'url': 'http://purl.obolibrary.org/obo/HP_0031153', 'lbl': 'Membranous vitreous appearance', 'desc': 'label: Membranous vitreous appearance\ndefinition : Vitreous humor of the eye displaying consisting of a vestigial gel in the retrolental space bounded by a convoluted membrane.\nsynonyms :Membranous anomaly; Membranous vitreous; Membranous vitreous phenotype\n'}


{'id': 'HP_0031154', 'url': 'http://purl.obolibrary.org/obo/HP_0031154', 'lbl': 'Beaded vitreous appearance', 'desc': 'label: Beaded vitreous appearance\ndefinition : Vitreous humor of the eye displaying beaded bundles of irregular diameters.\nsynonyms :\n'}


{'id': 'HP_0031155', 'url': 'http://purl.obolibrary.org/obo/HP_0031155', 'lbl': 'Increased Arden ratio of electrooculogram', 'desc': 'label: Increased Arden ratio of electrooculogram\ndefinition : An abnormal increase in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record.\nsynonyms :Increased Arden ratio of EOG\n'}


{'id': 'HP_0031156', 'url': 'http://purl.obolibrary.org/obo/HP_0031156', 'lbl': 'Decreased platelet glycoprotein Ib', 'desc': 'label: Decreased platelet glycoprotein Ib\ndefinition : Decreased platelet cell membrane concentration of glycoprotein Ib.\nsynonyms :\n'}


{'id': 'HP_0031157', 'url': 'http://purl.obolibrary.org/obo/HP_0031157', 'lbl': 'Carotid cavernous fistula', 'desc': 'label: Carotid cavernous fistula\ndefinition : An abnormal connection between a carotid artery and the cavernous sinus.\nsynonyms :Caroticocavernous fistula\n'}


{'id': 'HP_0031158', 'url': 'http://purl.obolibrary.org/obo/HP_0031158', 'lbl': 'Widened atrophic scar', 'desc': 'label: Widened atrophic scar\ndefinition : An atrophic scar (fibrous connective tissue resulting from incomplete healing of a wound) that has stretched (gotten wider), a manifestation of tissue fragility.\nsynonyms :\n'}


{'id': 'HP_0031159', 'url': 'http://purl.obolibrary.org/obo/HP_0031159', 'lbl': 'Thinning of Descemet membrane', 'desc': "label: Thinning of Descemet membrane\ndefinition : A reduction in the thickness of Descemet's membrane.\nsynonyms :\n"}


{'id': 'HP_0031160', 'url': 'http://purl.obolibrary.org/obo/HP_0031160', 'lbl': 'Myelokathexis', 'desc': 'label: Myelokathexis\ndefinition : Impaired egress of mature neutrophils from bone marrow causing neutropenia.\nsynonyms :\n'}


{'id': 'HP_0031161', 'url': 'http://purl.obolibrary.org/obo/HP_0031161', 'lbl': 'Reduced brain glutamate level by MRS', 'desc': 'label: Reduced brain glutamate level by MRS\ndefinition : An decrease in the level of glutamate (Glu) in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :\n'}


{'id': 'HP_0031162', 'url': 'http://purl.obolibrary.org/obo/HP_0031162', 'lbl': 'Impaired oropharyngeal swallow response', 'desc': 'label: Impaired oropharyngeal swallow response\ndefinition : Delay or absence of the swallow response, reflexes triggered by the contact the food bolus makes with the anterior faucial pillars.\nsynonyms :\n'}


{'id': 'HP_0031163', 'url': 'http://purl.obolibrary.org/obo/HP_0031163', 'lbl': 'Low femoral bone density', 'desc': 'label: Low femoral bone density\ndefinition : Reduced bone mineral density of the femur.\nsynonyms :Low femur bone density\n'}


{'id': 'HP_0031164', 'url': 'http://purl.obolibrary.org/obo/HP_0031164', 'lbl': 'Growth arrest lines', 'desc': 'label: Growth arrest lines\ndefinition : Growth arrest lines are alternating transverse rings of sclerosis at the metaphysis of a long bone.\nsynonyms :Growth resumption lines; Harris lines\n'}


{'id': 'HP_0031165', 'url': 'http://purl.obolibrary.org/obo/HP_0031165', 'lbl': 'Multifocal seizures', 'desc': 'label: Multifocal seizures\ndefinition : Seizures that start from several different areas of the brain (i.e., with multiple ictal onset locations).\nsynonyms :Multifocal onset seizures\n'}


{'id': 'HP_0031166', 'url': 'http://purl.obolibrary.org/obo/HP_0031166', 'lbl': 'Eyelid myokymia', 'desc': 'label: Eyelid myokymia\ndefinition : Involuntary, fine, continuous, undulating contractions of the eyelid.\nsynonyms :Myokymia orbicularis; Orbicularis myokymia\n'}


{'id': 'HP_0031167', 'url': 'http://purl.obolibrary.org/obo/HP_0031167', 'lbl': 'Triggered by ingestion of potassium-rich food', 'desc': 'label: Triggered by ingestion of potassium-rich food\ndefinition : Applies to a sign or symptom that is provoked or brought about by eating or drinking foods rich in potassium.\nsynonyms :Potassium-rich food triggered symptoms; Triggered by ingestion of K-rich food\n'}


{'id': 'HP_0031169', 'url': 'http://purl.obolibrary.org/obo/HP_0031169', 'lbl': 'Postterm pregnancy', 'desc': 'label: Postterm pregnancy\ndefinition : A pregnancy that extends to 42 weeks of gestation or beyond.\nsynonyms :\n'}


{'id': 'HP_0031170', 'url': 'http://purl.obolibrary.org/obo/HP_0031170', 'lbl': 'Female fetal virilization', 'desc': 'label: Female fetal virilization\ndefinition : Fetal masculinization of female external genitalia.\nsynonyms :Female foetal virilization\n'}


{'id': 'HP_0031171', 'url': 'http://purl.obolibrary.org/obo/HP_0031171', 'lbl': 'Femoral spur', 'desc': 'label: Femoral spur\ndefinition : A bony projection (spur, osteophyte) originating from the femur, often in the medial femoral neck.\nsynonyms :Spurring of femur\n'}


{'id': 'HP_0031172', 'url': 'http://purl.obolibrary.org/obo/HP_0031172', 'lbl': 'Sectoral retinitis pigmentosa', 'desc': 'label: Sectoral retinitis pigmentosa\ndefinition : A variant of retinitis pigmentosa in which there is a regional distribution of the retinal degeneration.\nsynonyms :\n'}


{'id': 'HP_0031173', 'url': 'http://purl.obolibrary.org/obo/HP_0031173', 'lbl': 'Tibial spur', 'desc': 'label: Tibial spur\ndefinition : A bony projection (spur, osteophyte) originating from the tibia.\nsynonyms :Spurring of tibiae\n'}


{'id': 'HP_0031174', 'url': 'http://purl.obolibrary.org/obo/HP_0031174', 'lbl': 'Double-layered patella', 'desc': 'label: Double-layered patella\ndefinition : An anomaly of the patella characterized by two layers visible on lateral knee X-ray such that one layer is in front of the other in the sagittal orientation (See Figure 2A and 3B of PMID:12966518). This finding persists into adulthood.\nsynonyms :\n'}


{'id': 'HP_0031175', 'url': 'http://purl.obolibrary.org/obo/HP_0031175', 'lbl': 'Absent cervical vertebra', 'desc': 'label: Absent cervical vertebra\ndefinition : A developmental defect characterized by agenesis of one or more vertebral bodies of the cervical spine.\nsynonyms :\n'}


{'id': 'HP_0031176', 'url': 'http://purl.obolibrary.org/obo/HP_0031176', 'lbl': 'Absent thoracic vertebra', 'desc': 'label: Absent thoracic vertebra\ndefinition : A developmental defect characterized by agenesis of one or more vertebral bodies of the thoracic spine.\nsynonyms :\n'}


{'id': 'HP_0031177', 'url': 'http://purl.obolibrary.org/obo/HP_0031177', 'lbl': 'Finger flexor weakness', 'desc': 'label: Finger flexor weakness\ndefinition : Reduced ability to flex (bend) the fingers. This can manifest as incomplete closure of the hand due to weakness in finger flexion.\nsynonyms :\n'}


{'id': 'HP_0031178', 'url': 'http://purl.obolibrary.org/obo/HP_0031178', 'lbl': 'Fixed head retroflexion', 'desc': 'label: Fixed head retroflexion\ndefinition : Head is bent in the posterior direction in a permanent fashion.\nsynonyms :\n'}


{'id': 'HP_0031179', 'url': 'http://purl.obolibrary.org/obo/HP_0031179', 'lbl': 'Nuchal rigidity', 'desc': 'label: Nuchal rigidity\ndefinition : Resistance of the extensor muscles of the neck to being bent forwards (i.e., impaired neck flexion) as a result of muscle spasm of the extensor muscles of the neck. Nuchal rigidity is not a fixed rigidity. Nuchal rigidity has been used as a bedside test for meningism, although its sensitivity for this purpose has been debated.\nsynonyms :Meningism\n'}


{'id': 'HP_0031180', 'url': 'http://purl.obolibrary.org/obo/HP_0031180', 'lbl': 'Erythema migrans', 'desc': 'label: Erythema migrans\ndefinition : An expanding erythematous (red) skin lesion, usually round or oval, by definition at least 5 cm in size (in largest diameter).\nsynonyms :Erythema chronicum migrans\n'}


{'id': 'HP_0031181', 'url': 'http://purl.obolibrary.org/obo/HP_0031181', 'lbl': 'Necrolytic migratory erythema', 'desc': 'label: Necrolytic migratory erythema\ndefinition : Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution.\nsynonyms :\n'}


{'id': 'HP_0031185', 'url': 'http://purl.obolibrary.org/obo/HP_0031185', 'lbl': 'Increased circulating NT-proBNP concentration', 'desc': 'label: Increased circulating NT-proBNP concentration\ndefinition : An elevated level of circulating N-terminal part of the prohormone of B-type natriuretic peptide (BNP).\nsynonyms :Increased NT-proBNP level\n'}


{'id': 'HP_0031186', 'url': 'http://purl.obolibrary.org/obo/HP_0031186', 'lbl': 'Abnormal circulating deoxycorticosterone level', 'desc': 'label: Abnormal circulating deoxycorticosterone level\ndefinition : An abnormality of the concentration of deoxycorticosterone in the blood. Deoxycorticosterone comprises 11-deoxycorticosterone and 21-deoxycorticosterone.\nsynonyms :\n'}


{'id': 'HP_0031187', 'url': 'http://purl.obolibrary.org/obo/HP_0031187', 'lbl': 'Abnormal circulating pregnenolone concentration', 'desc': 'label: Abnormal circulating pregnenolone concentration\ndefinition : An abnormality of the concentration of pregnenolone in the blood.\nsynonyms :Abnormality of circulating pregnenolone level\n'}


{'id': 'HP_0031188', 'url': 'http://purl.obolibrary.org/obo/HP_0031188', 'lbl': 'Genital edema', 'desc': 'label: Genital edema\ndefinition : A buildup of fluid that causes swelling in the soft tissues of the genital area.\nsynonyms :Genital oedema\n'}


{'id': 'HP_0031189', 'url': 'http://purl.obolibrary.org/obo/HP_0031189', 'lbl': 'Wrist drop', 'desc': 'label: Wrist drop\ndefinition : A condition in which the affected individual cannot extend the wrist, which hangs flaccidly.\nsynonyms :\n'}


{'id': 'HP_0031190', 'url': 'http://purl.obolibrary.org/obo/HP_0031190', 'lbl': 'Superficial dermal perivascular inflammatory infiltrate', 'desc': 'label: Superficial dermal perivascular inflammatory infiltrate\ndefinition : Numerous lymphocytes surrounding blood vessels in the superfical part of the dermis.\nsynonyms :Superficial perivascular inflammatory infiltrate\n'}


{'id': 'HP_0031191', 'url': 'http://purl.obolibrary.org/obo/HP_0031191', 'lbl': 'Deep dermal perivascular inflammatory infiltrate', 'desc': 'label: Deep dermal perivascular inflammatory infiltrate\ndefinition : Numerous lymphocytes surrounding blood vessels in the deep part of the dermis.\nsynonyms :Deep perivascular inflammatory infiltrate\n'}


{'id': 'HP_0031192', 'url': 'http://purl.obolibrary.org/obo/HP_0031192', 'lbl': 'Abnormal morphology of left ventricular trabeculae', 'desc': 'label: Abnormal morphology of left ventricular trabeculae\ndefinition : Any structural anomaly of the muscular columns which project from the inner surface of the left ventricle of the heart (cardiac trabeculae, trabeculae carneae).\nsynonyms :\n'}


{'id': 'HP_0031193', 'url': 'http://purl.obolibrary.org/obo/HP_0031193', 'lbl': 'Abnormal morphology of right ventricular trabeculae', 'desc': 'label: Abnormal morphology of right ventricular trabeculae\ndefinition : Any structural anomaly of the muscular columns which project from the inner surface of the right ventricle of the heart (cardiac trabeculae, trabeculae carneae).\nsynonyms :\n'}


{'id': 'HP_0031194', 'url': 'http://purl.obolibrary.org/obo/HP_0031194', 'lbl': 'Increased density of left ventricular trabeculae', 'desc': 'label: Increased density of left ventricular trabeculae\ndefinition : An increased density (number and tightness) of the muscular columns which project from the inner surface of the left ventricles of the heart (cardiac trabeculae, trabeculae carneae).\nsynonyms :\n'}


{'id': 'HP_0031195', 'url': 'http://purl.obolibrary.org/obo/HP_0031195', 'lbl': 'Apical hypertrabeculation of the left ventricle', 'desc': 'label: Apical hypertrabeculation of the left ventricle\ndefinition : An increased number and density of the trabeculae in the apex (tip) of the left ventricle.\nsynonyms :\n'}


{'id': 'HP_0031196', 'url': 'http://purl.obolibrary.org/obo/HP_0031196', 'lbl': 'Thin myocardium compact layer', 'desc': 'label: Thin myocardium compact layer\ndefinition : Reduced thickness of the outer, dense layer of the myocardium.\nsynonyms :\n'}


{'id': 'HP_0031197', 'url': 'http://purl.obolibrary.org/obo/HP_0031197', 'lbl': 'Cellular urinary casts', 'desc': 'label: Cellular urinary casts\ndefinition : A type of urinary cast composed of cells incorporated in a protein matrix. The cells can be those found in the urinary sediment (erythrocytes, leuklocytes, renal tubular epithelial cells).\nsynonyms :Cellular casts\n'}


{'id': 'HP_0031198', 'url': 'http://purl.obolibrary.org/obo/HP_0031198', 'lbl': 'Renal tubular epithelial cell casts', 'desc': 'label: Renal tubular epithelial cell casts\ndefinition : A type of cellular urinary cast composed of renal tubular epithelial cells.\nsynonyms :\n'}


{'id': 'HP_0031199', 'url': 'http://purl.obolibrary.org/obo/HP_0031199', 'lbl': 'Acellular urinary casts', 'desc': 'label: Acellular urinary casts\ndefinition : A type of urinary cast composed of a proteinaceous matrix without a substantial number of cells.\nsynonyms :Acellular casts\n'}


{'id': 'HP_0031200', 'url': 'http://purl.obolibrary.org/obo/HP_0031200', 'lbl': 'Hyaline casts', 'desc': 'label: Hyaline casts\ndefinition : A type of acellular urinary cast that are composed only of Tamm-Horsfall glycoprotein, a fact which explains their low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends.\nsynonyms :\n'}


{'id': 'HP_0031201', 'url': 'http://purl.obolibrary.org/obo/HP_0031201', 'lbl': 'Granular casts', 'desc': 'label: Granular casts\ndefinition : A type of acelluar casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented.\nsynonyms :\n'}


{'id': 'HP_0031202', 'url': 'http://purl.obolibrary.org/obo/HP_0031202', 'lbl': 'Waxy casts', 'desc': 'label: Waxy casts\ndefinition : A type of acellular urinary casts that display a melted wax (waxy) appearance, which gives them a high refractive index. They are frequently dark, with blunt extremities, indented and cracked edges and a large size, which is often several times that of other types of casts.\nsynonyms :\n'}


{'id': 'HP_0031203', 'url': 'http://purl.obolibrary.org/obo/HP_0031203', 'lbl': 'Fatty casts', 'desc': 'label: Fatty casts\ndefinition : A type of acellular urinary casts that contain lipid droplets, oval fat bodies or cholesterol crystals, and are often associated with the free forms of these elements. Their identification may require the use of polarised light microscopy, under which fatty particles embedded into the cast matrix appear as Maltese crosses.\nsynonyms :\n'}


{'id': 'HP_0031204', 'url': 'http://purl.obolibrary.org/obo/HP_0031204', 'lbl': 'Bacterial cell casts', 'desc': 'label: Bacterial cell casts\ndefinition : A type of urinary cast that contain bacteria. Bacterial casts can be difficult to identify and can be distinguished from other types of casts using phase contrast microscopy. Bacterial casts are diagnostic of acute pyelonephritis or intrinsic renal infection.\nsynonyms :\n'}


{'id': 'HP_0031205', 'url': 'http://purl.obolibrary.org/obo/HP_0031205', 'lbl': 'Reduced lysosomal acid lipase activity', 'desc': 'label: Reduced lysosomal acid lipase activity\ndefinition : Reduction in the activity of lysosomal acid lipase (LAL) in the blood. Lysosomal lipase activity is measured. LAL hydrolyzes cholesteryl esters derived from cell internalization of plasma lipoproteins.\nsynonyms :Reduced leukocyte acid lipase activity\n'}


{'id': 'HP_0031206', 'url': 'http://purl.obolibrary.org/obo/HP_0031206', 'lbl': 'Striatal T2 hyperintensity', 'desc': 'label: Striatal T2 hyperintensity\ndefinition : Abnormally bright T2 signal from the striatum on brain magnetic resonance imaging.\nsynonyms :\n'}


{'id': 'HP_0031207', 'url': 'http://purl.obolibrary.org/obo/HP_0031207', 'lbl': 'Hepatic hemangioma', 'desc': 'label: Hepatic hemangioma\ndefinition : A congenital vascular malformation in the liver composed of masses of blood vessels that are atypical or irregular in arrangement and size.\nsynonyms :Hemangioma of the liver; Liver hemangioma\n'}


{'id': 'HP_0031208', 'url': 'http://purl.obolibrary.org/obo/HP_0031208', 'lbl': 'Increased pituitary glycoprotein hormone alpha subunit level', 'desc': 'label: Increased pituitary glycoprotein hormone alpha subunit level\ndefinition : An increased concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081). This alpha subunit is common to luteinizing hormone (LH) , follicle stimulating hormone (FSH) , thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), which are glycoprotein hormones composed of an identical alpha subunit together with a beta subunit that confers biological specificity. The alpha subunit is used as a marker for tumors that produce these hormones.\nsynonyms :Increased pituitary glycoprotein alpha subunit level; Increased pituitary glycoprotein polypeptide alpha subunit level\n'}


{'id': 'HP_0031209', 'url': 'http://purl.obolibrary.org/obo/HP_0031209', 'lbl': 'Decreased circulating lipoprotein lipase concentration', 'desc': 'label: Decreased circulating lipoprotein lipase concentration\ndefinition : Reduction in the level of lipoprotein lipase in the blood.\nsynonyms :Decreased lipoprotein lipase level\n'}


{'id': 'HP_0031210', 'url': 'http://purl.obolibrary.org/obo/HP_0031210', 'lbl': 'Abnormal circulating hyaluronic acid concentration', 'desc': 'label: Abnormal circulating hyaluronic acid concentration\ndefinition : A deviation from the normal concentration of hyaluronic acid in the blood.\nsynonyms :\n'}


{'id': 'HP_0031211', 'url': 'http://purl.obolibrary.org/obo/HP_0031211', 'lbl': 'Elevated cholesterol ester level', 'desc': 'label: Elevated cholesterol ester level\ndefinition : An elevated concentration of circulating cholesterol esters, which are fatty acid esters of cholesterol and make up about two-thirds of total plasma cholesterol.\nsynonyms :Elevated cholesteryl ester level; Increased cholesterol esters; Increased cholesteryl esters\n'}


{'id': 'HP_0031212', 'url': 'http://purl.obolibrary.org/obo/HP_0031212', 'lbl': 'Abnormal circulating progesterone level', 'desc': 'label: Abnormal circulating progesterone level\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0031213', 'url': 'http://purl.obolibrary.org/obo/HP_0031213', 'lbl': 'Elevated circulating 17-hydroxyprogesterone concentration', 'desc': 'label: Elevated circulating 17-hydroxyprogesterone concentration\ndefinition : An increased level of 17-hydroxyprogesterone in the blood. 17-hydroxyprogesterone is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase.\nsynonyms :Elevated circulating 17-OHP; Elevated circulating 17-hydroxyprogesterone\n'}


{'id': 'HP_0031214', 'url': 'http://purl.obolibrary.org/obo/HP_0031214', 'lbl': 'Decreased circulating dehydroepiandrosterone concentration', 'desc': 'label: Decreased circulating dehydroepiandrosterone concentration\ndefinition : \nsynonyms :Decreased circulating dehydroepiandrosterone level\n'}


{'id': 'HP_0031215', 'url': 'http://purl.obolibrary.org/obo/HP_0031215', 'lbl': 'Decreased circulating dehydroepiandrosterone-sulfate concentration', 'desc': 'label: Decreased circulating dehydroepiandrosterone-sulfate concentration\ndefinition : A reduced concentration of dehydroepiandrosterone-sulfate in the blood.\nsynonyms :Decreased circulating dehydroepiandrosterone-sulfate level\n'}


{'id': 'HP_0031216', 'url': 'http://purl.obolibrary.org/obo/HP_0031216', 'lbl': 'Increased circulating progesterone', 'desc': 'label: Increased circulating progesterone\ndefinition : An elevated concentration of progesterone in the blood.\nsynonyms :\n'}


{'id': 'HP_0031217', 'url': 'http://purl.obolibrary.org/obo/HP_0031217', 'lbl': 'Hot flashes', 'desc': 'label: Hot flashes\ndefinition : Sudden feelings of warmth that are generally most pronounced over the face, neck and chest.\nsynonyms :\n'}


{'id': 'HP_0031218', 'url': 'http://purl.obolibrary.org/obo/HP_0031218', 'lbl': 'Inappropriate antidiuretic hormone secretion', 'desc': 'label: Inappropriate antidiuretic hormone secretion\ndefinition : A state of increased circulating antidiuretic hormone despite hyponatremia and hypo-osmolality with normal or increased plasma volume.\nsynonyms :Inappropriate ADH secretion; SIADH; Syndrome of inappropriate antidiuretic hormone secretion\n'}


{'id': 'HP_0031219', 'url': 'http://purl.obolibrary.org/obo/HP_0031219', 'lbl': 'Reduced radioactive iodine uptake', 'desc': 'label: Reduced radioactive iodine uptake\ndefinition : A decreased amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.\nsynonyms :\n'}


{'id': 'HP_0031220', 'url': 'http://purl.obolibrary.org/obo/HP_0031220', 'lbl': 'Increased radioactive iodine uptake', 'desc': 'label: Increased radioactive iodine uptake\ndefinition : An elevated amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.\nsynonyms :\n'}


{'id': 'HP_0031221', 'url': 'http://purl.obolibrary.org/obo/HP_0031221', 'lbl': 'Abnormal radioactive iodine uptake test result', 'desc': 'label: Abnormal radioactive iodine uptake test result\ndefinition : Any deviation from normal in the amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.\nsynonyms :\n'}


{'id': 'HP_0031222', 'url': 'http://purl.obolibrary.org/obo/HP_0031222', 'lbl': 'Increased circulating thyroxine-binding globulin level', 'desc': 'label: Increased circulating thyroxine-binding globulin level\ndefinition : An elevated concentration of thyroxine-binding globulin (TBG) in the blood.\nsynonyms :Thyroxine-binding globulin high in blood\n'}


{'id': 'HP_0031223', 'url': 'http://purl.obolibrary.org/obo/HP_0031223', 'lbl': 'Focal pancreatic islet hyperplasia', 'desc': 'label: Focal pancreatic islet hyperplasia\ndefinition : Hyperplasia of the islets of Langerhans that affects only certain regions of the pancreas and not others.\nsynonyms :\n'}


{'id': 'HP_0031224', 'url': 'http://purl.obolibrary.org/obo/HP_0031224', 'lbl': 'Diffuse pancreatic islet hyperplasia', 'desc': 'label: Diffuse pancreatic islet hyperplasia\ndefinition : Hyperplasia of the islets of Langerhans with a generalized distribution.\nsynonyms :\n'}


{'id': 'HP_0031225', 'url': 'http://purl.obolibrary.org/obo/HP_0031225', 'lbl': 'Intrapulmonary shunt', 'desc': 'label: Intrapulmonary shunt\ndefinition : Blood flow through a region of the lung in which little or no ventilation takes place, resulting in reduced oxygenation of the blood leaving the lungs.\nsynonyms :Intrapulmonary shunting\n'}


{'id': 'HP_0031226', 'url': 'http://purl.obolibrary.org/obo/HP_0031226', 'lbl': 'Perinephric fluid collection', 'desc': 'label: Perinephric fluid collection\ndefinition : An accumulation of fluid in one or more of the perinephric spaces, which consist of the subcapsular, perirenal, anterior and posterior pararenal spaces. This abnormality can be demonstrated by cross-sectional imaging, particularly computed tomography.\nsynonyms :\n'}


{'id': 'HP_0031227', 'url': 'http://purl.obolibrary.org/obo/HP_0031227', 'lbl': 'Nasopharyngeal teratoma', 'desc': 'label: Nasopharyngeal teratoma\ndefinition : A teratoma arising in the nasopharyngeal region.\nsynonyms :\n'}


{'id': 'HP_0031228', 'url': 'http://purl.obolibrary.org/obo/HP_0031228', 'lbl': 'Abnormal incisura morphology', 'desc': 'label: Abnormal incisura morphology\ndefinition : An abnormal shape of the incisura, defined as the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by the antitragus, and along its lower lateral margins and inferior boundary by the connection between the first two. The upper boundary is a somewhat arbitrary line crossing from the apices of the antitragus and the tragus.\nsynonyms :\n'}


{'id': 'HP_0031229', 'url': 'http://purl.obolibrary.org/obo/HP_0031229', 'lbl': 'Increased incisura length', 'desc': 'label: Increased incisura length\ndefinition : The length of the incisura from the upper to lower border is greater than that observed in the average population.\nsynonyms :\n'}


{'id': 'HP_0031230', 'url': 'http://purl.obolibrary.org/obo/HP_0031230', 'lbl': 'Decreased incisura length', 'desc': 'label: Decreased incisura length\ndefinition : The length of the incisura from the upper to lower border is less than that observed in the average population.\nsynonyms :\n'}


{'id': 'HP_0031231', 'url': 'http://purl.obolibrary.org/obo/HP_0031231', 'lbl': 'Narrow incisura width', 'desc': 'label: Narrow incisura width\ndefinition : Width of the incisura from the anterior to posterior border less than that observed in the average population.\nsynonyms :\n'}


{'id': 'HP_0031232', 'url': 'http://purl.obolibrary.org/obo/HP_0031232', 'lbl': 'Increased incisura width', 'desc': 'label: Increased incisura width\ndefinition : Breadth of the incisura from the anterior to posterior border greater than that observed in the average population.\nsynonyms :\n'}


{'id': 'HP_0031233', 'url': 'http://purl.obolibrary.org/obo/HP_0031233', 'lbl': 'Horizontal inferior border of scapula', 'desc': 'label: Horizontal inferior border of scapula\ndefinition : A morphological abnormality of the scapula in which there is a flat (horizontal) inferior edge of the scapula. The entire scapula is said to resemble a square, leading to the designation sqaring of the scapula (in Figure 1 of PMID:24706940 the scapulae have a roughly rectangular shape).\nsynonyms :Squaring of the inferior scapulae; Squaring of the scapula\n'}


{'id': 'HP_0031234', 'url': 'http://purl.obolibrary.org/obo/HP_0031234', 'lbl': 'Neutrophilic infiltration of the skin', 'desc': 'label: Neutrophilic infiltration of the skin\ndefinition : A predominantly neutrophilic infiltrate of the dermis and or epidermis (i.e., a large number of neutrophils inferred to have migrated into the skin).\nsynonyms :\n'}


{'id': 'HP_0031235', 'url': 'http://purl.obolibrary.org/obo/HP_0031235', 'lbl': 'Predominantly epidermal neutrophilic infiltrate', 'desc': 'label: Predominantly epidermal neutrophilic infiltrate\ndefinition : Collection of neutrophils in the epidermis.\nsynonyms :\n'}


{'id': 'HP_0031236', 'url': 'http://purl.obolibrary.org/obo/HP_0031236', 'lbl': 'Predominantly dermal neutrophilic infiltrate', 'desc': 'label: Predominantly dermal neutrophilic infiltrate\ndefinition : Collection of neutrophils in the dermis.\nsynonyms :\n'}


{'id': 'HP_0031237', 'url': 'http://purl.obolibrary.org/obo/HP_0031237', 'lbl': 'Internally nucleated skeletal muscle fibers', 'desc': 'label: Internally nucleated skeletal muscle fibers\ndefinition : An abnormally increased proportion of nuclei of sarcomeres with an internal localization. Individual muscle fibers are syncytia, formed by embryonic fusion of many myoblasts or later, myosatellite cells. Each muscle fiber contains many nuclei, peripherally positioned immediately adjacent to the sarcolemmal membrane. In healthy muscle only 3-5% of fibers contain nuclei that are located internally, within the cell, but many disease processes lead to internal nuclei.\nsynonyms :Internally nucleated skeletal muscle fibres\n'}


{'id': 'HP_0031238', 'url': 'http://purl.obolibrary.org/obo/HP_0031238', 'lbl': 'Necklace skeletal muscle fibers', 'desc': 'label: Necklace skeletal muscle fibers\ndefinition : A histological alteration of muscle fibers that resembles a necklace (necklace fibers). A substantial proportion of fibers (4-20% in PMID:19084976) show internalized nuclei aligned in a basophilic ring (necklace) at 3 micrometers beneath the sarcolemma. Ultrastructurally, such necklaces consist of myofibrils of smaller diameter, in oblique orientation, surrounded by mitochondria, sarcoplasmic reticulum and glycogen granules.\nsynonyms :Necklace skeletal muscle fibres\n'}


{'id': 'HP_0031239', 'url': 'http://purl.obolibrary.org/obo/HP_0031239', 'lbl': 'Extrafoveal choroidal neovascularization', 'desc': 'label: Extrafoveal choroidal neovascularization\ndefinition : A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 200 to 1500 micrometers from the center of the fovea.\nsynonyms :\n'}


{'id': 'HP_0031240', 'url': 'http://purl.obolibrary.org/obo/HP_0031240', 'lbl': 'Juxtafoveal choroidal neovascularization', 'desc': 'label: Juxtafoveal choroidal neovascularization\ndefinition : A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 1 to 199 micrometers from the center of the fovea.\nsynonyms :\n'}


{'id': 'HP_0031241', 'url': 'http://purl.obolibrary.org/obo/HP_0031241', 'lbl': 'Subfoveal choroidal neovascularization', 'desc': 'label: Subfoveal choroidal neovascularization\ndefinition : A type of choroidal neovascularization in which the area of neovascularization overlaps with the center of the fovea.\nsynonyms :\n'}


{'id': 'HP_0031242', 'url': 'http://purl.obolibrary.org/obo/HP_0031242', 'lbl': 'Decreased circulating chylomicron concentration', 'desc': 'label: Decreased circulating chylomicron concentration\ndefinition : Reduced plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins.\nsynonyms :Decreased circulating chylomicron levels; Hypochylomicronemia\n'}


{'id': 'HP_0031243', 'url': 'http://purl.obolibrary.org/obo/HP_0031243', 'lbl': 'Decreased VLDL cholesterol concentration', 'desc': 'label: Decreased VLDL cholesterol concentration\ndefinition : A reduction in the amount of very-low-density lipoprotein cholesterol in the blood.\nsynonyms :Decreased circulating very-low-density lipoprotein levels\n'}


{'id': 'HP_0031244', 'url': 'http://purl.obolibrary.org/obo/HP_0031244', 'lbl': 'Swollen lip', 'desc': 'label: Swollen lip\ndefinition : Enlargement of the lip typically due to fluid buildup or inflammation.\nsynonyms :Edematous lip; Swelling of the lip\n'}


{'id': 'HP_0031245', 'url': 'http://purl.obolibrary.org/obo/HP_0031245', 'lbl': 'Productive cough', 'desc': 'label: Productive cough\ndefinition : A cough that produces phlegm or mucus.\nsynonyms :Cough with mucus production; Wet cough\n'}


{'id': 'HP_0031246', 'url': 'http://purl.obolibrary.org/obo/HP_0031246', 'lbl': 'Nonproductive cough', 'desc': 'label: Nonproductive cough\ndefinition : A cough that does not produce phlegm or mucus.\nsynonyms :Dry cough; Dry coughing\n'}


{'id': 'HP_0031247', 'url': 'http://purl.obolibrary.org/obo/HP_0031247', 'lbl': 'Whooping cough', 'desc': 'label: Whooping cough\ndefinition : A type of cough characterized by a burst of numerous and rapid coughs followed by a long inhaling effort that is accompanied by a high-pitched whooping sound produced by the inhalation of air.\nsynonyms :\n'}


{'id': 'HP_0031248', 'url': 'http://purl.obolibrary.org/obo/HP_0031248', 'lbl': 'Palmar pruritus', 'desc': 'label: Palmar pruritus\ndefinition : Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the palm(s) of the hand.\nsynonyms :Itchy palm\n'}


{'id': 'HP_0031249', 'url': 'http://purl.obolibrary.org/obo/HP_0031249', 'lbl': 'Parageusia', 'desc': 'label: Parageusia\ndefinition : A distortion of the sense of taste, often characterized by the sensation of a metallic taste.\nsynonyms :Altered sense of taste; Dysgeusia; Metallic taste; Metallic taste in mouth\n'}


{'id': 'HP_0031250', 'url': 'http://purl.obolibrary.org/obo/HP_0031250', 'lbl': 'Lip fissure', 'desc': 'label: Lip fissure\ndefinition : A severe crack in a lip. A lip fissure may be painful, may bleed and often is a recurring manifestation.\nsynonyms :\n'}


{'id': 'HP_0031251', 'url': 'http://purl.obolibrary.org/obo/HP_0031251', 'lbl': 'Abnormal subclavian artery morphology', 'desc': 'label: Abnormal subclavian artery morphology\ndefinition : Any anomaly of a subclavian artery.\nsynonyms :\n'}


{'id': 'HP_0031252', 'url': 'http://purl.obolibrary.org/obo/HP_0031252', 'lbl': 'Dilated left subclavian artery', 'desc': 'label: Dilated left subclavian artery\ndefinition : Abnormally increased caliber of the left subclavian artery.\nsynonyms :\n'}


{'id': 'HP_0031253', 'url': 'http://purl.obolibrary.org/obo/HP_0031253', 'lbl': 'Anomalous origin of left subclavian artery', 'desc': 'label: Anomalous origin of left subclavian artery\ndefinition : Origin of the left subclavian artery from an anomalous anatomical location.\nsynonyms :\n'}


{'id': 'HP_0031254', 'url': 'http://purl.obolibrary.org/obo/HP_0031254', 'lbl': 'Thalamic arteriovenous malformation', 'desc': 'label: Thalamic arteriovenous malformation\ndefinition : An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the thalamus.\nsynonyms :\n'}


{'id': 'HP_0031255', 'url': 'http://purl.obolibrary.org/obo/HP_0031255', 'lbl': 'Hypothalamic arteriovenous malformation', 'desc': 'label: Hypothalamic arteriovenous malformation\ndefinition : An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the hypothalamus.\nsynonyms :\n'}


{'id': 'HP_0031256', 'url': 'http://purl.obolibrary.org/obo/HP_0031256', 'lbl': 'Optic nerve arteriovenous malformation', 'desc': 'label: Optic nerve arteriovenous malformation\ndefinition : An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the optic nerve.\nsynonyms :\n'}


{'id': 'HP_0031257', 'url': 'http://purl.obolibrary.org/obo/HP_0031257', 'lbl': 'Arteriovenous malformation of the maxilla', 'desc': 'label: Arteriovenous malformation of the maxilla\ndefinition : An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the maxilla.\nsynonyms :\n'}


{'id': 'HP_0031258', 'url': 'http://purl.obolibrary.org/obo/HP_0031258', 'lbl': 'Delirium', 'desc': 'label: Delirium\ndefinition : A state of sudden and severe confusion.\nsynonyms :\n'}


{'id': 'HP_0031259', 'url': 'http://purl.obolibrary.org/obo/HP_0031259', 'lbl': 'Oophoritis', 'desc': 'label: Oophoritis\ndefinition : An inflammation of the ovary or ovaries.\nsynonyms :Inflammed ovary\n'}


{'id': 'HP_0031260', 'url': 'http://purl.obolibrary.org/obo/HP_0031260', 'lbl': 'Triangular tibia', 'desc': 'label: Triangular tibia\ndefinition : A short, dysplastic tibia with a triangular shape. Instead of the normal shaft configuration of the tibia, the tibia forms a triangle with the longest side corresponding to the proximal-distal dimension, and the apex of the triangle directed laterally.\nsynonyms :\n'}


{'id': 'HP_0031261', 'url': 'http://purl.obolibrary.org/obo/HP_0031261', 'lbl': 'Bladder polyp', 'desc': 'label: Bladder polyp\ndefinition : An abnormal growth that projects from the mucous membrane of the urinary bladder.\nsynonyms :\n'}


{'id': 'HP_0031263', 'url': 'http://purl.obolibrary.org/obo/HP_0031263', 'lbl': 'Abnormal renal corpuscle morphology', 'desc': 'label: Abnormal renal corpuscle morphology\ndefinition : Any anomolous structure of the renal corpuscle, which is the initial component of the nephron that filters blood. The renal corpuscle consists of a knot of capillaries (glomerulus) that is surrounded by a double-walled capsule (Bowman capsule) that opens into a renal tubule.\nsynonyms :\n'}


{'id': 'HP_0031264', 'url': 'http://purl.obolibrary.org/obo/HP_0031264', 'lbl': 'Abnormal Bowman capsule morphology', 'desc': "label: Abnormal Bowman capsule morphology\ndefinition : A structural anomaly of the double-walled capsule (Bowman capsule) that opens into a renal tubule.\nsynonyms :Abnormal morphology of Bowman capsule; Abnormal morphology of Bowman's capsule; Abnormal renal glomerular capsule morphology\n"}


{'id': 'HP_0031265', 'url': 'http://purl.obolibrary.org/obo/HP_0031265', 'lbl': 'Abnormal glomerular visceral epithelial cell morphology', 'desc': 'label: Abnormal glomerular visceral epithelial cell morphology\ndefinition : Any structural anomaly of the podocyte, which is a highly specialized cell of the Bowman capsule and which forms multiple interdigitating foot processes. Podocytes are interconnected by slit diaphragms and cover the exterior basement membrane surface of the glomerular capillary.\nsynonyms :Abnormal podocyte morphology; Abnormal visceral epithelial cell morphology\n'}


{'id': 'HP_0031266', 'url': 'http://purl.obolibrary.org/obo/HP_0031266', 'lbl': 'Podocyte foot process effacement', 'desc': 'label: Podocyte foot process effacement\ndefinition : An anomaly of podocyte morphology characterized by the loss of the interdigitating foot process pattern (generally called foot process effacement; FPE). The term FPE designates the loss of the usual interdigitating pattern of foot processes of neighboring podocytes, leading to relatively broad expanses of podocyte processes covering the glomerular basement membrane (GBM). It is widely viewed as a pathological derangement that is associated with leakage of macromolecules such as albumin through the glomerular filtration barrier.\nsynonyms :Loss of primary podocyte processes\n'}


{'id': 'HP_0031267', 'url': 'http://purl.obolibrary.org/obo/HP_0031267', 'lbl': 'Abnormal CD69 upregulation upon TCR activation', 'desc': 'label: Abnormal CD69 upregulation upon TCR activation\ndefinition : Any abnormality in the upregulation of CD69 on T cells after activation via the T cell receptor (TCR). Upregulation of CD69 is one of the earliest and most sensitive measures of antigen recognition in the periphery, and transient expression of CD69 is associated with positive selection in the thymus.\nsynonyms :\n'}


{'id': 'HP_0031268', 'url': 'http://purl.obolibrary.org/obo/HP_0031268', 'lbl': 'Decreased CD69 upregulation upon TCR activation', 'desc': 'label: Decreased CD69 upregulation upon TCR activation\ndefinition : Reduced or impaired upregulation of CD69 on T cells after activation via the T cell receptor (TCR).\nsynonyms :\n'}


{'id': 'HP_0031269', 'url': 'http://purl.obolibrary.org/obo/HP_0031269', 'lbl': 'Abnormal CD25 upregulation upon TCR activation', 'desc': 'label: Abnormal CD25 upregulation upon TCR activation\ndefinition : Any abnormality in the upregulation of CD25 on T cells after activation via the T cell receptor (TCR). CD25 is the alpha chain of the IL2 receptor. Ligation of the T cell antigen receptor leads to the induction of CD25 expression.\nsynonyms :\n'}


{'id': 'HP_0031270', 'url': 'http://purl.obolibrary.org/obo/HP_0031270', 'lbl': 'Decreased CD25 upregulation upon TCR activation', 'desc': 'label: Decreased CD25 upregulation upon TCR activation\ndefinition : Decreased or impaired upregulation of CD25 on T cells after activation via the T cell receptor (TCR).\nsynonyms :Poor CD25 upregulation upon TCR activation; Reduced IL2RA upregulation upon TCR activation\n'}


{'id': 'HP_0031271', 'url': 'http://purl.obolibrary.org/obo/HP_0031271', 'lbl': 'Absent ankle pulse', 'desc': 'label: Absent ankle pulse\ndefinition : The pulsation of the posterior tibial artery behind the internal malleolus, or of the dorsalis pedis artery, cannot be detected on physical examination.\nsynonyms :\n'}


{'id': 'HP_0031272', 'url': 'http://purl.obolibrary.org/obo/HP_0031272', 'lbl': 'Pulmonary arterial atherosclerosis', 'desc': 'label: Pulmonary arterial atherosclerosis\ndefinition : Accumulation of lipids and inflammatory cells along the inner walls of the pulmonary artery.\nsynonyms :\n'}


{'id': 'HP_0031273', 'url': 'http://purl.obolibrary.org/obo/HP_0031273', 'lbl': 'Shock', 'desc': 'label: Shock\ndefinition : The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.\nsynonyms :\n'}


{'id': 'HP_0031274', 'url': 'http://purl.obolibrary.org/obo/HP_0031274', 'lbl': 'Hypovolemic shock', 'desc': 'label: Hypovolemic shock\ndefinition : A state of shock characterized by decreased circulating blood volume in relation to total vascular capacity. This type of shock is characterized by a reduction of diastolic filling pressures.\nsynonyms :\n'}


{'id': 'HP_0031275', 'url': 'http://purl.obolibrary.org/obo/HP_0031275', 'lbl': 'Distributive shock', 'desc': 'label: Distributive shock\ndefinition : A hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage\nsynonyms :\n'}


{'id': 'HP_0031276', 'url': 'http://purl.obolibrary.org/obo/HP_0031276', 'lbl': 'Obstructive shock', 'desc': 'label: Obstructive shock\ndefinition : A type of shock characterized by inadequate cardiac preload due to obstructed venous return (e.g. pericardial tamponade, tension pneumothorax, abdominal compartment) or obstruction of arterial blood flow (e.g. pulmonary embolism).\nsynonyms :\n'}


{'id': 'HP_0031278', 'url': 'http://purl.obolibrary.org/obo/HP_0031278', 'lbl': 'Abnormal thoracic duct morphology', 'desc': 'label: Abnormal thoracic duct morphology\ndefinition : Any structural anomaly of the thoracic duct.\nsynonyms :\n'}


{'id': 'HP_0031279', 'url': 'http://purl.obolibrary.org/obo/HP_0031279', 'lbl': 'Abnormal response to gonadotropin-releasing hormone stimulation test', 'desc': 'label: Abnormal response to gonadotropin-releasing hormone stimulation test\ndefinition : An abnormal response to the gonadotropin-releasing hormone (GnRH) stimulation test. This test typically involves intravenous administration of GnRH followed by repeated blood sampling at various time points to measure the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).\nsynonyms :Abnormal response to GnRH stimulation test\n'}


{'id': 'HP_0031280', 'url': 'http://purl.obolibrary.org/obo/HP_0031280', 'lbl': 'Increased LH response to gonadotropin-releasing hormone stimulation test', 'desc': 'label: Increased LH response to gonadotropin-releasing hormone stimulation test\ndefinition : An abnormally high amount of luteinizing hormone (LH) is released upon gonadotropin-releasing hormone stimulation test.\nsynonyms :\n'}


{'id': 'HP_0031281', 'url': 'http://purl.obolibrary.org/obo/HP_0031281', 'lbl': 'Sialadenitis', 'desc': 'label: Sialadenitis\ndefinition : Inflammation of a salivary gland.\nsynonyms :\n'}


{'id': 'HP_0031282', 'url': 'http://purl.obolibrary.org/obo/HP_0031282', 'lbl': 'Malalignment of the great toenail', 'desc': 'label: Malalignment of the great toenail\ndefinition : A lateral deviation of the nail plate of the great toe along the longitudinal axis due to the lateral rotation of the nail matrix. The nail plate grows out in ridges.\nsynonyms :\n'}