{'id': 'HP_0032909', 'url': 'http://purl.obolibrary.org/obo/HP_0032909', 'lbl': 'Focal impaired awareness automatism seizure', 'desc': 'label: Focal impaired awareness automatism seizure\ndefinition : A focal seizure with automatism in which awareness is partially or fully impaired at some point during the seizure.\nsynonyms :\n'}


{'id': 'HP_0032910', 'url': 'http://purl.obolibrary.org/obo/HP_0032910', 'lbl': 'Focal aware automatism seizure', 'desc': 'label: Focal aware automatism seizure\ndefinition : A type of focal automatism seizure during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0032911', 'url': 'http://purl.obolibrary.org/obo/HP_0032911', 'lbl': 'Focal aware orofacial automatism seizure', 'desc': 'label: Focal aware orofacial automatism seizure\ndefinition : A type of focal automatism seizure characterized by orofacial automatisms at onset and during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0032912', 'url': 'http://purl.obolibrary.org/obo/HP_0032912', 'lbl': 'Focal aware manual automatism seizure', 'desc': 'label: Focal aware manual automatism seizure\ndefinition : A type of focal automatism seizure characterized by manual automatisms at onset and during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0032913', 'url': 'http://purl.obolibrary.org/obo/HP_0032913', 'lbl': 'Focal aware pedal automatism seizure', 'desc': 'label: Focal aware pedal automatism seizure\ndefinition : A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset and during which awareness is fully retained throughout. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.\nsynonyms :\n'}


{'id': 'HP_0032914', 'url': 'http://purl.obolibrary.org/obo/HP_0032914', 'lbl': 'Focal aware perseverative automatism seizure', 'desc': 'label: Focal aware perseverative automatism seizure\ndefinition : A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset and during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0032915', 'url': 'http://purl.obolibrary.org/obo/HP_0032915', 'lbl': 'Focal aware vocal automatism seizure', 'desc': 'label: Focal aware vocal automatism seizure\ndefinition : A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset and during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0032916', 'url': 'http://purl.obolibrary.org/obo/HP_0032916', 'lbl': 'Focal aware verbal automatism seizure', 'desc': 'label: Focal aware verbal automatism seizure\ndefinition : A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset and during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0032917', 'url': 'http://purl.obolibrary.org/obo/HP_0032917', 'lbl': 'Focal aware sexual automatism seizure', 'desc': 'label: Focal aware sexual automatism seizure\ndefinition : A type of focal automatism seizure characterized by involuntary sexual behavior at onset and during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0032918', 'url': 'http://purl.obolibrary.org/obo/HP_0032918', 'lbl': 'Focal impaired awareness orofacial automatism seizure', 'desc': 'label: Focal impaired awareness orofacial automatism seizure\ndefinition : A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by orofacial automatisms at onset.\nsynonyms :\n'}


{'id': 'HP_0032919', 'url': 'http://purl.obolibrary.org/obo/HP_0032919', 'lbl': 'Focal aware head nodding automatism seizure', 'desc': 'label: Focal aware head nodding automatism seizure\ndefinition : A type of focal automatism seizure characterized by involuntary head nodding at onset and during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0032920', 'url': 'http://purl.obolibrary.org/obo/HP_0032920', 'lbl': 'Focal impaired awareness manual automatism seizure', 'desc': 'label: Focal impaired awareness manual automatism seizure\ndefinition : A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by manual automatisms at onset.\nsynonyms :\n'}


{'id': 'HP_0032921', 'url': 'http://purl.obolibrary.org/obo/HP_0032921', 'lbl': 'Focal impaired awareness pedal automatism seizure', 'desc': 'label: Focal impaired awareness pedal automatism seizure\ndefinition : A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.\nsynonyms :\n'}


{'id': 'HP_0032922', 'url': 'http://purl.obolibrary.org/obo/HP_0032922', 'lbl': 'Focal impaired awareness perseverative automatism seizure', 'desc': 'label: Focal impaired awareness perseverative automatism seizure\ndefinition : A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by inappropriate continuation of pre-seizure movement or behavior at onset.\nsynonyms :\n'}


{'id': 'HP_0032923', 'url': 'http://purl.obolibrary.org/obo/HP_0032923', 'lbl': 'Focal impaired awareness vocal automatism seizure', 'desc': 'label: Focal impaired awareness vocal automatism seizure\ndefinition : A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset.\nsynonyms :\n'}


{'id': 'HP_0032924', 'url': 'http://purl.obolibrary.org/obo/HP_0032924', 'lbl': 'Focal impaired awareness verbal automatism seizure', 'desc': 'label: Focal impaired awareness verbal automatism seizure\ndefinition : A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive words, phrases, or brief sentences at onset.\nsynonyms :\n'}


{'id': 'HP_0032925', 'url': 'http://purl.obolibrary.org/obo/HP_0032925', 'lbl': 'Focal impaired awareness sexual automatism seizure', 'desc': 'label: Focal impaired awareness sexual automatism seizure\ndefinition : A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by involuntary sexual behavior at onset.\nsynonyms :\n'}


{'id': 'HP_0032926', 'url': 'http://purl.obolibrary.org/obo/HP_0032926', 'lbl': 'Focal impaired awareness head nodding automatism seizure', 'desc': 'label: Focal impaired awareness head nodding automatism seizure\ndefinition : A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary head nodding at onset.\nsynonyms :\n'}


{'id': 'HP_0032927', 'url': 'http://purl.obolibrary.org/obo/HP_0032927', 'lbl': 'Focal impaired awareness undressing automatism seizure', 'desc': 'label: Focal impaired awareness undressing automatism seizure\ndefinition : A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary undressing at onset.\nsynonyms :\n'}


{'id': 'HP_0032928', 'url': 'http://purl.obolibrary.org/obo/HP_0032928', 'lbl': 'Elevated CSF neurofilament light chain concentration', 'desc': 'label: Elevated CSF neurofilament light chain concentration\ndefinition : Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases.\nsynonyms :Elevated CSF neurofilament light chain\n'}


{'id': 'HP_0032929', 'url': 'http://purl.obolibrary.org/obo/HP_0032929', 'lbl': 'Abnormal chondrocyte morphology', 'desc': 'label: Abnormal chondrocyte morphology\ndefinition : Any abnormal structure of a chondrocyte, which is a polymorphic cell that forms cartilage.\nsynonyms :\n'}


{'id': 'HP_0032930', 'url': 'http://purl.obolibrary.org/obo/HP_0032930', 'lbl': 'Lacunar halos around chondrocytes', 'desc': 'label: Lacunar halos around chondrocytes\ndefinition : Concentric rings around the chondrocytes.\nsynonyms :\n'}


{'id': 'HP_0032931', 'url': 'http://purl.obolibrary.org/obo/HP_0032931', 'lbl': 'obsolete Focal impaired awareness cognitive seizure with impaired attention', 'desc': 'label: obsolete Focal impaired awareness cognitive seizure with impaired attention\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032932', 'url': 'http://purl.obolibrary.org/obo/HP_0032932', 'lbl': 'Increased circulating pancreatic triacylglycerol lipase level', 'desc': 'label: Increased circulating pancreatic triacylglycerol lipase level\ndefinition : An increased level of triacylglycerol lipase in the blood circulation (can be measured in serum or plasma).\nsynonyms :Elevated circulating pancreatic triacylglycerol lipase activity\n'}


{'id': 'HP_0032933', 'url': 'http://purl.obolibrary.org/obo/HP_0032933', 'lbl': 'Airway hyperresponsiveness', 'desc': 'label: Airway hyperresponsiveness\ndefinition : An increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to the agonist.\nsynonyms :\n'}


{'id': 'HP_0032934', 'url': 'http://purl.obolibrary.org/obo/HP_0032934', 'lbl': 'Spontaneous cerebrospinal fluid leak', 'desc': 'label: Spontaneous cerebrospinal fluid leak\ndefinition : A spontaneous cerebrospinal fluid leak (SCSFL) is a spontaneous and unexplained leak of the cerebrospinal fluid from the dura surrounding either the brain (cranial leak) or spine (spinal leak).\nsynonyms :\n'}


{'id': 'HP_0032935', 'url': 'http://purl.obolibrary.org/obo/HP_0032935', 'lbl': 'Posterior crocodile shagreen of the cornea', 'desc': 'label: Posterior crocodile shagreen of the cornea\ndefinition : Grayish, polygonal pattern of opacities with intervening clear zones across the central cornea that resembles crocodile skin.\nsynonyms :\n'}


{'id': 'HP_0032936', 'url': 'http://purl.obolibrary.org/obo/HP_0032936', 'lbl': 'Intrusion symptom', 'desc': 'label: Intrusion symptom\ndefinition : Unintentional reexperiencing a traumatic event comprising symptoms are usually sensory impressions and emotional responses from the trauma that appear to lack a time perspective and a context.\nsynonyms :Re-experiencing symptom\n'}


{'id': 'HP_0032937', 'url': 'http://purl.obolibrary.org/obo/HP_0032937', 'lbl': 'Recurrent, involuntary and intrusive distressing memories', 'desc': "label: Recurrent, involuntary and intrusive distressing memories\ndefinition : After suffering psychological trauma, people can repeatedly experience sensory-perceptual impressions of the event, which intrude involuntarily into consciousness. These intrusive memories typically take the form of visual images (e.g., pictures in the mind's eye), but can also include sounds, smells, tastes and bodily sensations, and come with a range of negative emotions associated with the hotspots in the trauma memory.\nsynonyms :\n"}


{'id': 'HP_0032938', 'url': 'http://purl.obolibrary.org/obo/HP_0032938', 'lbl': 'Recurrent trauma-related distressing dreams', 'desc': 'label: Recurrent trauma-related distressing dreams\ndefinition : Recurrent distressing dreams in which the content and/or affect of the dream are related to the traumatic event or events.\nsynonyms :\n'}


{'id': 'HP_0032939', 'url': 'http://purl.obolibrary.org/obo/HP_0032939', 'lbl': 'Physiological reactivity to cues', 'desc': 'label: Physiological reactivity to cues\ndefinition : Marked physiological reactions to internal or external cues that symbolize or resemble an aspect of the traumatic event(s).\nsynonyms :\n'}


{'id': 'HP_0032940', 'url': 'http://purl.obolibrary.org/obo/HP_0032940', 'lbl': 'Dissociative reaction', 'desc': 'label: Dissociative reaction\ndefinition : A disruption and/or discontinuity in the normal integration of consciousness, memory, identity, emotion, perception, body representation, motor control, and behavior. Clinical presentations of dissociation may include a wide variety of symptoms, including experiences of depersonalization, derealisation, emotional numbing, flashbacks of traumatic events, absorption, amnesia, voice hearing, interruptions in awareness, and identity alteration.\nsynonyms :\n'}


{'id': 'HP_0032941', 'url': 'http://purl.obolibrary.org/obo/HP_0032941', 'lbl': 'Intense psychological distress to cues', 'desc': 'label: Intense psychological distress to cues\ndefinition : Intense or prolonged psychological distress at exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event or events.\nsynonyms :\n'}


{'id': 'HP_0032942', 'url': 'http://purl.obolibrary.org/obo/HP_0032942', 'lbl': 'Avoidance of stimuli associated with traumatic event', 'desc': 'label: Avoidance of stimuli associated with traumatic event\ndefinition : Avoidance of or efforts to avoid distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s). Avoidance of or efforts to avoid external reminders (people, places, conversations, activities, objects, situations) that arouse distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s).\nsynonyms :\n'}


{'id': 'HP_0032943', 'url': 'http://purl.obolibrary.org/obo/HP_0032943', 'lbl': 'Abnormal urine pH', 'desc': 'label: Abnormal urine pH\ndefinition : A deviation of urine pH from the normal range of 4.5 to 7.8.\nsynonyms :\n'}


{'id': 'HP_0032944', 'url': 'http://purl.obolibrary.org/obo/HP_0032944', 'lbl': 'Alkaline urine', 'desc': 'label: Alkaline urine\ndefinition : Urine pH of 8 or higher.\nsynonyms :\n'}


{'id': 'HP_0032945', 'url': 'http://purl.obolibrary.org/obo/HP_0032945', 'lbl': 'Renal interstitial inflammation', 'desc': 'label: Renal interstitial inflammation\ndefinition : Histopathological findings of inflammation of the renal interstitium potentially involving fibrotic as well as non-fibrotic areas, composed of lymphocytes, monocytes, plasma cells.\nsynonyms :\n'}


{'id': 'HP_0032946', 'url': 'http://purl.obolibrary.org/obo/HP_0032946', 'lbl': 'Renal cortical interstitial inflammation', 'desc': 'label: Renal cortical interstitial inflammation\ndefinition : Histopathological findings of inflammation of the renal interstitium involving fibrotic as well as non-fibrotic renal cortex, composed of lymphocytes, monocytes, plasma cells.\nsynonyms :\n'}


{'id': 'HP_0032947', 'url': 'http://purl.obolibrary.org/obo/HP_0032947', 'lbl': 'Renal medullary interstitial inflammation', 'desc': 'label: Renal medullary interstitial inflammation\ndefinition : Histopathological findings of inflammation of the interstitium of the renal medulla, composed of lymphocytes, monocytes, plasma cells.\nsynonyms :\n'}


{'id': 'HP_0032948', 'url': 'http://purl.obolibrary.org/obo/HP_0032948', 'lbl': 'Renal interstitial fibrosis', 'desc': 'label: Renal interstitial fibrosis\ndefinition : The accumulation of collagen and related extracellular matrix (ECM) molecules in the interstitium of the kidney. The interstitium is expanded by the presence of collagen that stain blue on trichrome. Tubules are not back to back, but rather separated by fibrosis and can be atrophic.\nsynonyms :\n'}


{'id': 'HP_0032949', 'url': 'http://purl.obolibrary.org/obo/HP_0032949', 'lbl': 'Renal interstitial calcium phosphate deposits', 'desc': 'label: Renal interstitial calcium phosphate deposits\ndefinition : The presence of interstitial aggregates of purple finely granular/laminated calcium- and phosphate deposits.\nsynonyms :\n'}


{'id': 'HP_0032950', 'url': 'http://purl.obolibrary.org/obo/HP_0032950', 'lbl': 'Abnormal renal tubular lumen morphology', 'desc': 'label: Abnormal renal tubular lumen morphology\ndefinition : Abnormal structure or form of the lumen (opening) of kidney tubules.\nsynonyms :Abnormal renal tubular luminal morphology\n'}


{'id': 'HP_0032951', 'url': 'http://purl.obolibrary.org/obo/HP_0032951', 'lbl': 'Renal tubular viral cytopathic changes', 'desc': 'label: Renal tubular viral cytopathic changes\ndefinition : Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. Distal tubules are more commonly involved than proximal tubules. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbers of neutrophils, with interstitial edema and hemorrhage. Tubular destruction may be associated with necrotizing interstitial granulomas. Severe granulomatous tubulointerstitial nephritis appears to be characteristic of adenoviral infection and is quite rare in other viral infections. Focal wedge-shaped necrosis may occur in renal parenchyma. Immunostaining for adenovirus shows strong nuclear and cytoplasmic staining in infected cells.\nsynonyms :\n'}


{'id': 'HP_0032952', 'url': 'http://purl.obolibrary.org/obo/HP_0032952', 'lbl': 'Usual-type tubular atrophy', 'desc': 'label: Usual-type tubular atrophy\ndefinition : A type of renal tubular atrophy in which the tubules show thick tubular basement membranes lined by small cuboidal or flat cells. Generally accompanied by fibrosis.\nsynonyms :Common-type renal tubular atrophy\n'}


{'id': 'HP_0032953', 'url': 'http://purl.obolibrary.org/obo/HP_0032953', 'lbl': 'Renal tubular cytomegalovirus inclusions', 'desc': "label: Renal tubular cytomegalovirus inclusions\ndefinition : Characteristic intranuclear glassy-appearing basophilic inclusions with surrounding halo (owl's eye-type inclusion) and marked increase in the size of the cell (cytomegaly), particularly in tubular epithelial cells and in endothelial cells. Often accompanied by cytopathic changes including patchy interstitial pleomorphic infiltrate with lymphocytes, plasma cells, and macrophages.\nsynonyms :\n"}


{'id': 'HP_0032954', 'url': 'http://purl.obolibrary.org/obo/HP_0032954', 'lbl': 'Renal tubular adenovirus inclusions', 'desc': 'label: Renal tubular adenovirus inclusions\ndefinition : Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. The inclusions stain positive for adenovirus (e.g., Figure 3 of PMID:29273157). Distal tubules are more commonly involved than proximal tubules. Occasionally glomerular visceral and parietal epithelial cells can be infected. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbersof neutrophils, with interstitial edema and hemorrhage.\nsynonyms :\n'}


{'id': 'HP_0032955', 'url': 'http://purl.obolibrary.org/obo/HP_0032955', 'lbl': 'Renal tubular polyoma virus inclusions', 'desc': 'label: Renal tubular polyoma virus inclusions\ndefinition : Renal ltubular nuclear inclusions have a ground-glass appearance with irregular central clearing, or a coarse, vesicular appearance. Distal tubules are involved more often than proximal tubules. There may be only medullary involvement in early stages, and parietal epithelial cells may be involved in later stages of the infection. Infected epithelial cell nuclei stain with antibody to the large T antigen of the SV40 virus, which serves as a surrogate marker of human polyomavirus infection.\nsynonyms :\n'}


{'id': 'HP_0032956', 'url': 'http://purl.obolibrary.org/obo/HP_0032956', 'lbl': 'Renal tubular herpes simplex virus inclusions', 'desc': 'label: Renal tubular herpes simplex virus inclusions\ndefinition : Renal tubular nuclear inclusions that stain positive for herpes simplex virus (HSV). HSV is typically associated with multinucleated giant cells with nuclear inclusions and may cause hemorrhagic interstitial nephritis.\nsynonyms :\n'}


{'id': 'HP_0032957', 'url': 'http://purl.obolibrary.org/obo/HP_0032957', 'lbl': 'Dysmorphic hematuria', 'desc': 'label: Dysmorphic hematuria\ndefinition : The presence of dysmorphic urinary erythrocytes. This feature can be observed by phase-contrastmicroscopy, differential interference microscopy, and bright-field microscopy. The acanthocyte or G1 cell, which is a doughnut-shaped cell with one or more blebs, is reported to constitute a special form of dysmorphic erythro-cyte (D cell) specific for glomerular hematuria.\nsynonyms :Acanthocyturia\n'}


{'id': 'HP_0032958', 'url': 'http://purl.obolibrary.org/obo/HP_0032958', 'lbl': 'Urinary oval fat bodies', 'desc': 'label: Urinary oval fat bodies\ndefinition : The presence in the urine of desquamated tubular epithelial cells or macrophages filled with lipid droplets.\nsynonyms :\n'}


{'id': 'HP_0032959', 'url': 'http://purl.obolibrary.org/obo/HP_0032959', 'lbl': 'Intratubular calcium oxalate casts', 'desc': 'label: Intratubular calcium oxalate casts\ndefinition : Birefringent calcium- and oxalate-containing casts located within the tubuli of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032960', 'url': 'http://purl.obolibrary.org/obo/HP_0032960', 'lbl': 'Intratubular calcium phosphate casts', 'desc': 'label: Intratubular calcium phosphate casts\ndefinition : Purple and finely granular/laminated calcium- and phosphate-containing casts located within the tubuli of the kidney.\nsynonyms :\n'}


{'id': 'HP_0032961', 'url': 'http://purl.obolibrary.org/obo/HP_0032961', 'lbl': 'Magnesium ammonium phosphate crystalluria', 'desc': 'label: Magnesium ammonium phosphate crystalluria\ndefinition : Magnesium ammonium phosphate crystals in the urine.\nsynonyms :Struvite urinary crystals\n'}


{'id': 'HP_0032962', 'url': 'http://purl.obolibrary.org/obo/HP_0032962', 'lbl': 'Tubular microcystic change', 'desc': 'label: Tubular microcystic change\ndefinition : Dilated renal tubules (over twice the diameter of a normal proximal tubule) containing eosinophilic amorphous material. This feature is generally accompanied by scalloping of the cast profile. The epithelium lining the microcyst is generally flattened and does not reveal brush border.\nsynonyms :\n'}


{'id': 'HP_0032963', 'url': 'http://purl.obolibrary.org/obo/HP_0032963', 'lbl': 'Complex renal cyst', 'desc': 'label: Complex renal cyst\ndefinition : A renal cyst characterized by epithelium lined space (squamous/columnar) with septations.\nsynonyms :\n'}


{'id': 'HP_0032964', 'url': 'http://purl.obolibrary.org/obo/HP_0032964', 'lbl': 'Uric acid crystalluria', 'desc': 'label: Uric acid crystalluria\ndefinition : The presence of uric acid crystals in the urine.\nsynonyms :\n'}


{'id': 'HP_0032965', 'url': 'http://purl.obolibrary.org/obo/HP_0032965', 'lbl': 'Interstitial emphysema', 'desc': 'label: Interstitial emphysema\ndefinition : Interstitial emphysema is characterized by air dissecting within the interstitium of the lung, typically in the peribronchovascular sheaths, interlobular septa, and visceral pleura. It is most commonly seen in neonates receiving mechanical ventilation. It is rarely recognized radiographically in adults and is infrequently seen on CT scans. It appears as perivascular lucent or low attenuating halos and small cysts.\nsynonyms :\n'}


{'id': 'HP_0032966', 'url': 'http://purl.obolibrary.org/obo/HP_0032966', 'lbl': 'Centrilobular emphysema', 'desc': 'label: Centrilobular emphysema\ndefinition : A type of emphysema characterized by destroyed centrilobular alveolar walls and enlargement of respiratory bronchioles and associated alveoli. This is the commonest form of emphysema in cigarette smokers. CT findings are centrilobular areas of decreased attenuation, usually without visible walls, of nonuniform distribution and predominantly located in upper lung zones.\nsynonyms :Centriacinar emphysema\n'}


{'id': 'HP_0032967', 'url': 'http://purl.obolibrary.org/obo/HP_0032967', 'lbl': 'Panacinar emphysema', 'desc': 'label: Panacinar emphysema\ndefinition : Panacinar emphysema involves all portions of the acinus and secondary pulmonary lobule more or less uniformly. It predominates in the lower lobes and is the form of emphysema associated with1-antitrypsin deficiency. CT scans show a generalized decrease of the lung parenchyma with a decrease in the caliber of blood vessels in the affected lung. Severe panacinar emphysema may coexist and merge with severe centrilobular emphysema. The appearance of feature less decreased attenuation may be indistinguishable from severe constrictive obliterative bronchiolitis.\nsynonyms :\n'}


{'id': 'HP_0032968', 'url': 'http://purl.obolibrary.org/obo/HP_0032968', 'lbl': 'Expiratory air trapping', 'desc': 'label: Expiratory air trapping\ndefinition : Abnormal retention of gas within a lung or part of a lung, as a result of airway obstuction of abnormalities in lung compliance. In the classic presentation, the lung will appear normal at inspiration, but on exhalation, the diseased portions of the lung which have lost connective tissue recoil will remain lucent while the healthy portions of the lung will become more dense due to atelectasis. This helps distinguish it from mosaic attenuation due to patchy fibrosis, as occurs with nonspecific interstitial pneumonia, and in early usual interstitial pneumonitis (the hallmark imaging diagnosis of interstitial lung disease) in which there is no change with inspiration and expiration.\nsynonyms :\n'}


{'id': 'HP_0032969', 'url': 'http://purl.obolibrary.org/obo/HP_0032969', 'lbl': 'Traction bronchiectasis', 'desc': 'label: Traction bronchiectasis\ndefinition : Distortion of the bronchial airways due to mechanical traction on the bronchi resulting from fibrosis of the surrounding lung parenchyma. CT findings represent irregular bronchial dilatation caused by surrounding retractile pulmonary fibrosis. Dilated airways are usually identifiable as such but may be seen as cysts.\nsynonyms :\n'}


{'id': 'HP_0032970', 'url': 'http://purl.obolibrary.org/obo/HP_0032970', 'lbl': 'Traction bronchiolectasis', 'desc': 'label: Traction bronchiolectasis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032971', 'url': 'http://purl.obolibrary.org/obo/HP_0032971', 'lbl': 'Computed tomographic halo sign', 'desc': 'label: Computed tomographic halo sign\ndefinition : CT finding of ground-glass opacity surrounding a nodule or mass. It was first described as a sign of hemorrhage around foci of invasive aspergillosis. The halo sign is nonspecific and may also be caused by hemorrhage associated with other types of nodules or by local pulmonary infiltration by neoplasm.\nsynonyms :CT halo sign\n'}


{'id': 'HP_0032972', 'url': 'http://purl.obolibrary.org/obo/HP_0032972', 'lbl': 'Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT', 'desc': 'label: Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT\ndefinition : A nodular pattern on pulmonary high-resolution computed tomography which are anatomically located centrally within secondary pulmonary lobules. Centrilobular nodules may be dense (i.e., solid) and of homogeneous opacity or ground-glass opacity, and may range from a few millimeters to about 1 cm in size. Because of the similar size of secondary lobules, centrilobular nodules often appear to be evenly spaced. Centrilobular nodules are usually separated from the pleural surfaces, fissures, and interlobular septa by a distance of at least several millimeters. They may appear patchy or diffuse in different diseases.\nsynonyms :\n'}


{'id': 'HP_0032973', 'url': 'http://purl.obolibrary.org/obo/HP_0032973', 'lbl': 'Abnormal bronchoalveolar lavage fluid morphology', 'desc': 'label: Abnormal bronchoalveolar lavage fluid morphology\ndefinition : Abnormal type or counts of nucleated immune cells and acellular components in bronchoalveolar lavage (BAL) fluid. BAL us performed with a fiberoptic bronchoscope in the wedged position within a selected bronchopulmonary segment. BAL is commonly used to inform the differential diagnosis of interstitial lung disease or to monitor therapeutic interventions.\nsynonyms :\n'}


{'id': 'HP_0032974', 'url': 'http://purl.obolibrary.org/obo/HP_0032974', 'lbl': 'Abnormal cellular composition of bronchoalveolar fluid', 'desc': 'label: Abnormal cellular composition of bronchoalveolar fluid\ndefinition : Deviation from the commonly in healthy people observe cellular distribution. Normal ranghes are macrophages over 80%, lymphocytes less than 15%, neutrophils less than 3%, eosinophils less than 0.5%, mast cells less than 0.5%.\nsynonyms :Abnormal cell differential of broncho-alveolar fluid\n'}


{'id': 'HP_0032975', 'url': 'http://purl.obolibrary.org/obo/HP_0032975', 'lbl': 'Abnormal bronchoalveolar fluid protein level', 'desc': 'label: Abnormal bronchoalveolar fluid protein level\ndefinition : Any deviation from the normal concentration of protein in the bronchoalveolar fluid.\nsynonyms :Abnormal biochemical composition of broncho-alveolar fluid; Abnormal level of proteins in the broncho-alveolar fluid\n'}


{'id': 'HP_0032976', 'url': 'http://purl.obolibrary.org/obo/HP_0032976', 'lbl': 'Elevated bronchoalveolar lavage fluid lymphocyte proportion', 'desc': 'label: Elevated bronchoalveolar lavage fluid lymphocyte proportion\ndefinition : Usually, Lymphoycytes make up less than 15% of all cells found in the bronchoalveloar lavage fluid. This elevated cell proportion can be induced by virus or drugs, or is associated with specific diseases.\nsynonyms :\n'}


{'id': 'HP_0032977', 'url': 'http://purl.obolibrary.org/obo/HP_0032977', 'lbl': 'Elevated bronchoalveolar lavage fluid neutrophil proportion', 'desc': 'label: Elevated bronchoalveolar lavage fluid neutrophil proportion\ndefinition : Usually, Neutrophils make up less than 3% of all cells found in the broncho-alveloar lavage fluid. In children, standard value of neutrophils is higher depending on their age (children under the age of 5 show a maximum value of 10%). This elevated cell proportion is a sign for acute and chronic infections (HP:0012387, HP:0006538) and can be associated to specific diseases.\nsynonyms :Elevated level of neutrophils in broncho-alveolar lavage fluid\n'}


{'id': 'HP_0032978', 'url': 'http://purl.obolibrary.org/obo/HP_0032978', 'lbl': 'Lipid-laden macrophages in bronchoalveolar fluid', 'desc': 'label: Lipid-laden macrophages in bronchoalveolar fluid\ndefinition : Accumulation of lipids in alveolar macrophages with droplet-shaped fat inclusions.\nsynonyms :\n'}


{'id': 'HP_0032979', 'url': 'http://purl.obolibrary.org/obo/HP_0032979', 'lbl': 'Hemosiderin-laden macrophages in bronchoalveolar fluid', 'desc': 'label: Hemosiderin-laden macrophages in bronchoalveolar fluid\ndefinition : Hemosiderin-laden macrophages (HLM) in bronchoalveolar lavage (BAL) fluid were originally known as adiagnostic biomarker of alveolar hemorrhage, but have also been observed in idiopathic pulmonary fibrosis (IPF) with histopathological pattern of usual interstitial pneumonia (UIP).\nsynonyms :Accumulation of hemosiderin laden alveolar macrophages; Siderophages in bronchoalveolar fluid\n'}


{'id': 'HP_0032980', 'url': 'http://purl.obolibrary.org/obo/HP_0032980', 'lbl': 'Absent bronchoalveolar surfactant-protein C', 'desc': 'label: Absent bronchoalveolar surfactant-protein C\ndefinition : Significantly decreased level or failed detection of surfactant protein C in broncho-alveolar lavage fluid. Comment: Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions, whereas SP-B and SP-C are hydrophobic molecules, which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle. Lack of SP-C may result of surfactant metabolism dysfunction and is also observed in patients with other diffuse parenchymal lung diseaes, pathogenetically related to the alveolar surfactant region.\nsynonyms :\n'}


{'id': 'HP_0032981', 'url': 'http://purl.obolibrary.org/obo/HP_0032981', 'lbl': 'Absent bronchoalveolar dimeric surfactant-protein B', 'desc': 'label: Absent bronchoalveolar dimeric surfactant-protein B\ndefinition : Significantly decreased level or failed detection of surfactant protein B in broncho-alveolar lavage fluid.\nsynonyms :\n'}


{'id': 'HP_0032982', 'url': 'http://purl.obolibrary.org/obo/HP_0032982', 'lbl': 'obsolete Intraalveolar phospholipid accumulation', 'desc': 'label: obsolete Intraalveolar phospholipid accumulation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0032983', 'url': 'http://purl.obolibrary.org/obo/HP_0032983', 'lbl': 'Atoll sign', 'desc': 'label: Atoll sign\ndefinition : CT finding of central ground-glass opacity surrounded by denser consolidation of crescentic shape (forming more than three-fourths of a circle) or complete ring of at least 2 mm in thicknes. A rare sign, it was initially reported to be specific for cryptogenic organizing pneumonia, but was subsequently described in patients with paracoccidioidomycosis.\nsynonyms :Reversed halo sign\n'}


{'id': 'HP_0032984', 'url': 'http://purl.obolibrary.org/obo/HP_0032984', 'lbl': 'Abnormal alveolar macrophage morphology', 'desc': 'label: Abnormal alveolar macrophage morphology\ndefinition : Alveolar macrophages usually make up the majority of cells in the bronchoalveolar space (over 80%). The may contain intracellular material depending on underlying diseases or due to exposition to inhaled particles.\nsynonyms :\n'}


{'id': 'HP_0032985', 'url': 'http://purl.obolibrary.org/obo/HP_0032985', 'lbl': 'Dust particle inclusion in alveolar macrophages', 'desc': 'label: Dust particle inclusion in alveolar macrophages\ndefinition : Accumulation of inhaled, nondigestable particles in macrophages.\nsynonyms :\n'}


{'id': 'HP_0032986', 'url': 'http://purl.obolibrary.org/obo/HP_0032986', 'lbl': 'Smoker-inclusions in alveolar macrophages', 'desc': 'label: Smoker-inclusions in alveolar macrophages\ndefinition : In otherwise healthy smokers, characteristic so called smoker-inclusion can be found within the macrophages in the bronchoalveolar fluid. These blue/ black/ round/ oval cytoplasmic inclusions consist of pigmented lipid deposits.\nsynonyms :\n'}


{'id': 'HP_0032987', 'url': 'http://purl.obolibrary.org/obo/HP_0032987', 'lbl': 'Elevated bronchoalveolar lavage fluid eosinophil proportion', 'desc': 'label: Elevated bronchoalveolar lavage fluid eosinophil proportion\ndefinition : Usually, eosinophils make up less than 0.5% of all cells found in the broncho-alveloar lavage fluid. But in eosinophilic lung disease, the eosinophil cell proportion typically represents more than 25%. Comment: An elevated level of eosinophil cells are also a result of infections, or an allergic reaction or can be drug-induced.\nsynonyms :\n'}


{'id': 'HP_0032988', 'url': 'http://purl.obolibrary.org/obo/HP_0032988', 'lbl': 'Persistent head lag', 'desc': 'label: Persistent head lag\ndefinition : The Premie-Neuro and the Dubowitz Neurological Examination score head lag in the same manner. Scoring for both is as follows: 0 = head drops and stays back, 1 = tries to lift head but drops it back, 2 = able to lift head slightly, 3 = lifts head in line with body, and 4 = head in front of body. This term applies if head lag persists beyond an expected age at a level of 0 or 1. Persistent head lag beyond age 4 mo has been linked to poor outcomes.\nsynonyms :Head lag; Headlag\n'}


{'id': 'HP_0032989', 'url': 'http://purl.obolibrary.org/obo/HP_0032989', 'lbl': 'Delayed ability to roll over', 'desc': 'label: Delayed ability to roll over\ndefinition : Delayed ahcievement of the ability to roll front to back and back to front.\nsynonyms :\n'}


{'id': 'HP_0032990', 'url': 'http://purl.obolibrary.org/obo/HP_0032990', 'lbl': 'Localized pulmonary hemorrhage', 'desc': 'label: Localized pulmonary hemorrhage\ndefinition : Circumscribed pulmonary hemorrhage originating from a single bleeding site in the lungs. This can be due to infections, tumorigenesis, foreign bodies, or vascular abnormalities. Patient often feel the site of bleeding, contrast CT scan or angiography may localize the bleeder.\nsynonyms :Localised pulmonary haemorrhage\n'}


{'id': 'HP_0032991', 'url': 'http://purl.obolibrary.org/obo/HP_0032991', 'lbl': 'Abnormal pulmonary fissure morphology', 'desc': 'label: Abnormal pulmonary fissure morphology\ndefinition : An abnormal form or number of the pulmonary fissures.\nsynonyms :\n'}


{'id': 'HP_0032992', 'url': 'http://purl.obolibrary.org/obo/HP_0032992', 'lbl': 'Abnormal pulmonary fissure architecture', 'desc': 'label: Abnormal pulmonary fissure architecture\ndefinition : An abnormal form or location of a pulmonary fissure.\nsynonyms :\n'}


{'id': 'HP_0032993', 'url': 'http://purl.obolibrary.org/obo/HP_0032993', 'lbl': 'Abnormal pulmonary fissure count', 'desc': 'label: Abnormal pulmonary fissure count\ndefinition : A deviation from the normal number of pulmonary fissures.\nsynonyms :\n'}


{'id': 'HP_0032994', 'url': 'http://purl.obolibrary.org/obo/HP_0032994', 'lbl': 'Supernumerary pulmonary fissure', 'desc': 'label: Supernumerary pulmonary fissure\ndefinition : Presence of a lung fissure that does not exist normally. Supernumerary fissures include the superior accessory fissure, the medial basal fissure, the left horizontal fissure, and the azygos fissure form supernumerary lobes.\nsynonyms :increased pulmonary fissure count\n'}


{'id': 'HP_0032995', 'url': 'http://purl.obolibrary.org/obo/HP_0032995', 'lbl': 'Decreased pulmonary fissure count', 'desc': 'label: Decreased pulmonary fissure count\ndefinition : Lack of one or more of the normal pulmonary fissures.\nsynonyms :Reduced pulmonary fissure count\n'}


{'id': 'HP_0032996', 'url': 'http://purl.obolibrary.org/obo/HP_0032996', 'lbl': 'Abnormal cystatin C level', 'desc': 'label: Abnormal cystatin C level\ndefinition : Any deviation from the normal concentration of cystatin C in serum or plasma.\nsynonyms :\n'}


{'id': 'HP_0032997', 'url': 'http://purl.obolibrary.org/obo/HP_0032997', 'lbl': 'Decreased cystatin C level', 'desc': 'label: Decreased cystatin C level\ndefinition : A decreased concentration of cystatin C in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032998', 'url': 'http://purl.obolibrary.org/obo/HP_0032998', 'lbl': 'Increased cystatin C level', 'desc': 'label: Increased cystatin C level\ndefinition : A elevated concentration of cystatin C in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0032999', 'url': 'http://purl.obolibrary.org/obo/HP_0032999', 'lbl': 'Increased fecal porphyrin', 'desc': 'label: Increased fecal porphyrin\ndefinition : Abnormally high concentration of fecal porphyrins in feces.\nsynonyms :Increased faecal porphyrin\n'}


{'id': 'HP_0033000', 'url': 'http://purl.obolibrary.org/obo/HP_0033000', 'lbl': 'Subglottic laryngitis', 'desc': 'label: Subglottic laryngitis\ndefinition : Narrowing of the larynx, commonly occuring during viral respiratory tract infections, in particular in children, leads to symptoms such as hoarseness, a barking cough, stridor, and sometimes dyspnea and respiratory failure.\nsynonyms :Croup; Laryngitis; Pseudocroup; Spasmodic croup; Viral croup\n'}


{'id': 'HP_0033001', 'url': 'http://purl.obolibrary.org/obo/HP_0033001', 'lbl': 'Laryngeal papilloma', 'desc': 'label: Laryngeal papilloma\ndefinition : A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the larynx.\nsynonyms :Laryngeal papillomas; Laryngeal papillomatosis\n'}


{'id': 'HP_0033002', 'url': 'http://purl.obolibrary.org/obo/HP_0033002', 'lbl': 'Bronchial papilloma', 'desc': 'label: Bronchial papilloma\ndefinition : A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on a bronchus.\nsynonyms :\n'}


{'id': 'HP_0033003', 'url': 'http://purl.obolibrary.org/obo/HP_0033003', 'lbl': 'Tracheal papilloma', 'desc': 'label: Tracheal papilloma\ndefinition : A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the trachea.\nsynonyms :\n'}


{'id': 'HP_0033004', 'url': 'http://purl.obolibrary.org/obo/HP_0033004', 'lbl': 'Palmar warts', 'desc': 'label: Palmar warts\ndefinition : Multiple verrucous lesions on the skin of the palm. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by human papillomavirus (HPV).\nsynonyms :\n'}


{'id': 'HP_0033005', 'url': 'http://purl.obolibrary.org/obo/HP_0033005', 'lbl': 'Plantar warts', 'desc': 'label: Plantar warts\ndefinition : Multiple verrucous lesions on the skin of the sole of the foot. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by caused by human papillomavirus (HPV).\nsynonyms :\n'}


{'id': 'HP_0033006', 'url': 'http://purl.obolibrary.org/obo/HP_0033006', 'lbl': 'Diffuse alveolar damage', 'desc': 'label: Diffuse alveolar damage\ndefinition : Diffuse alveolar damage (DAD) describes a comon histologic injury pattern of the lung. The early stages are characterized by epithelial cell necrosis and sloughing, fibrous exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is acute respiratory distress syndrome (ARDS). DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis and crack cocaine inhalation.\nsynonyms :\n'}


{'id': 'HP_0033007', 'url': 'http://purl.obolibrary.org/obo/HP_0033007', 'lbl': 'Architectural distortion of the lung', 'desc': 'label: Architectural distortion of the lung\ndefinition : Architectural distortion is characterized by abnormal displacement of bronchi, vessels, fissures, or septa caused by diffuse or localized lung disease, particularly interstitial fibrosis. This is visible in lung biopsy and CT scans in a distorted appearance and is usually associated with pulmonary fibrosis and accompanied by volume loss.\nsynonyms :\n'}


{'id': 'HP_0033008', 'url': 'http://purl.obolibrary.org/obo/HP_0033008', 'lbl': 'Increased Z-disc width', 'desc': 'label: Increased Z-disc width\ndefinition : Abnormally increased width of the Z-disk of the sarcomere, resulting from splitting or opening of the Z-disc (c.f., Figure 2 of PMID:28732005).\nsynonyms :Increased Z-disk width; Widened z-discs\n'}


{'id': 'HP_0033009', 'url': 'http://purl.obolibrary.org/obo/HP_0033009', 'lbl': 'Increased fecal coproporphyrin 1', 'desc': 'label: Increased fecal coproporphyrin 1\ndefinition : Abnormally high concentration of coproporphyrin 1 in feces.\nsynonyms :Elevated faecal coproporphyrin 1; Elevated fecal coproporphyrin 1; Elevated stool coproporphyrin 1; High faecal coproporphyrin 1; High fecal coproporphyrin 1; High stool coproporphyrin 1; Increased faecal coproporphyrin 1\n'}


{'id': 'HP_0033010', 'url': 'http://purl.obolibrary.org/obo/HP_0033010', 'lbl': 'Increased fecal coproporphyrin 3', 'desc': 'label: Increased fecal coproporphyrin 3\ndefinition : Abnormally high concentration of coproporphyrin 3 in feces\nsynonyms :Elevated faecal coproporphyrin 3; Elevated fecal coproporphyrin 3; Elevated stool coproporphyrin 3; High faecal coproporphyrin 3; High fecal coproporphyrin 3; High stool coproporphyrin 3; Increased faecal coproporphyrin 3\n'}


{'id': 'HP_0033011', 'url': 'http://purl.obolibrary.org/obo/HP_0033011', 'lbl': 'Platystencephaly', 'desc': 'label: Platystencephaly\ndefinition : Extreme width of the skull in the occipital region, with anterior narrowing and prognathism.\nsynonyms :\n'}


{'id': 'HP_0033012', 'url': 'http://purl.obolibrary.org/obo/HP_0033012', 'lbl': 'Abnormal salivary metabolite concentration', 'desc': 'label: Abnormal salivary metabolite concentration\ndefinition : Any deviation from the normal concentration of a metabolite in saliva.\nsynonyms :\n'}


{'id': 'HP_0033013', 'url': 'http://purl.obolibrary.org/obo/HP_0033013', 'lbl': 'Abnormal salivary cortisol level', 'desc': 'label: Abnormal salivary cortisol level\ndefinition : Any deviation from the normal concentration of cortisol in saliva.\nsynonyms :\n'}


{'id': 'HP_0033014', 'url': 'http://purl.obolibrary.org/obo/HP_0033014', 'lbl': 'Decreased salivary cortisol level', 'desc': 'label: Decreased salivary cortisol level\ndefinition : Abnormally reduced concentration of cortisol in saliva.\nsynonyms :\n'}


{'id': 'HP_0033015', 'url': 'http://purl.obolibrary.org/obo/HP_0033015', 'lbl': 'Increased salivary cortisol level', 'desc': 'label: Increased salivary cortisol level\ndefinition : Abnormally elevated concentration of cortisol in saliva.\nsynonyms :\n'}


{'id': 'HP_0033016', 'url': 'http://purl.obolibrary.org/obo/HP_0033016', 'lbl': 'Chronic decreased circulating IgD', 'desc': 'label: Chronic decreased circulating IgD\ndefinition : A lasting reduction beneath the normal level of total immunoglobulin D (IgD) in the blood.\nsynonyms :Chronic decreased IgM in blood\n'}


{'id': 'HP_0033017', 'url': 'http://purl.obolibrary.org/obo/HP_0033017', 'lbl': 'Transient decreased circulating IgD', 'desc': 'label: Transient decreased circulating IgD\ndefinition : A temporary reduction beneath the normal level of total immunoglobulin D (IgD) in the blood circulation.\nsynonyms :Transient decreased IgD in blood\n'}


{'id': 'HP_0033018', 'url': 'http://purl.obolibrary.org/obo/HP_0033018', 'lbl': 'Chronic absent circulating IgD', 'desc': 'label: Chronic absent circulating IgD\ndefinition : A lasting absence of immunoglobulin D (IgD) in the blood, whereby at most trace quantities of IgD can be measured.\nsynonyms :Chronic (near) absent IgM in blood\n'}


{'id': 'HP_0033019', 'url': 'http://purl.obolibrary.org/obo/HP_0033019', 'lbl': 'Male reproductive system neoplasm', 'desc': 'label: Male reproductive system neoplasm\ndefinition : A neoplasm that affects the male reproductive system.\nsynonyms :\n'}


{'id': 'HP_0033020', 'url': 'http://purl.obolibrary.org/obo/HP_0033020', 'lbl': 'Female reproductive system neoplasm', 'desc': 'label: Female reproductive system neoplasm\ndefinition : A neoplasm that affects the female reproductive system.\nsynonyms :\n'}


{'id': 'HP_0033021', 'url': 'http://purl.obolibrary.org/obo/HP_0033021', 'lbl': 'Transient decreased circulating IgE', 'desc': 'label: Transient decreased circulating IgE\ndefinition : A temporary reduction beneath the normal level of total immunoglobulin E (IgE) in the blood.\nsynonyms :Transient decreased IgE in blood\n'}


{'id': 'HP_0033022', 'url': 'http://purl.obolibrary.org/obo/HP_0033022', 'lbl': 'Chronic decreased circulating IgE', 'desc': 'label: Chronic decreased circulating IgE\ndefinition : A lasting reduction beneath the normal level of total immunoglobulin E (IgE) in the blood.\nsynonyms :Chronic decreased IgE in blood\n'}


{'id': 'HP_0033023', 'url': 'http://purl.obolibrary.org/obo/HP_0033023', 'lbl': 'Chronic absent circulating IgE', 'desc': 'label: Chronic absent circulating IgE\ndefinition : A lasting absence of immunoglobulin E (IgE) in the blood circulation, whereby at most trace quantities of IgE can be measured.\nsynonyms :Chronic (near) absent IgE in blood\n'}


{'id': 'HP_0033024', 'url': 'http://purl.obolibrary.org/obo/HP_0033024', 'lbl': 'Transient decreased circulating IgA', 'desc': 'label: Transient decreased circulating IgA\ndefinition : A temporary reduction beneath the normal level of total immunoglobulin A (IgA) in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033025', 'url': 'http://purl.obolibrary.org/obo/HP_0033025', 'lbl': 'Chronic absent circulating total IgG', 'desc': 'label: Chronic absent circulating total IgG\ndefinition : A lasting absence of immunoglobulin G (IgG) in the blood, whereby at most trace quantities of IgG can be measured.\nsynonyms :Chronic (near) absent total IgG in blood\n'}


{'id': 'HP_0033026', 'url': 'http://purl.obolibrary.org/obo/HP_0033026', 'lbl': 'White oral mucosal macule', 'desc': 'label: White oral mucosal macule\ndefinition : A small circumscribed whitish change in the color of the oral mucosa that is neither elevated nor depressed.\nsynonyms :\n'}


{'id': 'HP_0033027', 'url': 'http://purl.obolibrary.org/obo/HP_0033027', 'lbl': "Retinal peau d'orange", 'desc': "label: Retinal peau d'orange\ndefinition : A pebbly orange appearance of the fundus that is said to resemble the skin of an orange.\nsynonyms :\n"}


{'id': 'HP_0033028', 'url': 'http://purl.obolibrary.org/obo/HP_0033028', 'lbl': 'Anti-U1 ribonucleoprotein antibody positivity', 'desc': 'label: Anti-U1 ribonucleoprotein antibody positivity\ndefinition : The presence autoantibodies in the serum that react to proteins (70 Kd, A, C) that are associated with U1 RNA and form U1snRNP.\nsynonyms :Anti-RNP-antibodies; Anti-U1-RNP antibody positivity; Anti-Scl-34 antibody positivity; Anti-U3 ribonucleoprotein antibody positivity\n'}


{'id': 'HP_0033029', 'url': 'http://purl.obolibrary.org/obo/HP_0033029', 'lbl': 'obsolete Anti-Jo-1 antibody positivity', 'desc': 'label: obsolete Anti-Jo-1 antibody positivity\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033030', 'url': 'http://purl.obolibrary.org/obo/HP_0033030', 'lbl': 'Anti-glomerular basement membrane-antibody positivity', 'desc': 'label: Anti-glomerular basement membrane-antibody positivity\ndefinition : The presence of autoantibodies in the serum that react to the glomerular basement membrane.\nsynonyms :Anti-GBM-antibody positivity\n'}


{'id': 'HP_0033031', 'url': 'http://purl.obolibrary.org/obo/HP_0033031', 'lbl': 'Hyperpyrexia', 'desc': 'label: Hyperpyrexia\ndefinition : An extreme elevation of core body temperature above normal defined as a rectal temperature of 41.1 degrees Celsius (106 degrees Fahrenheit).\nsynonyms :\n'}


{'id': 'HP_0033032', 'url': 'http://purl.obolibrary.org/obo/HP_0033032', 'lbl': 'Triggered by an abusive adult', 'desc': 'label: Triggered by an abusive adult\ndefinition : Applies to a sign or symptom that is induced by an abusive adult (usually a parent).\nsynonyms :Munchausen syndrome by proxy\n'}


{'id': 'HP_0033033', 'url': 'http://purl.obolibrary.org/obo/HP_0033033', 'lbl': 'Anti-MDA5 antibody positivity', 'desc': 'label: Anti-MDA5 antibody positivity\ndefinition : The presence of autoantibodies in the serum that react to Anti-MDA5 (Anti-melanoma differentiation-associated proteine 5).\nsynonyms :Increased level of anti-melanoma differentiation-associated protein 5 antibodies\n'}


{'id': 'HP_0033034', 'url': 'http://purl.obolibrary.org/obo/HP_0033034', 'lbl': 'Anti-citrullinated protein antibody positivity', 'desc': 'label: Anti-citrullinated protein antibody positivity\ndefinition : The presence autoantibodies in the serum that react do different citrullinated antigens, including filaggrin, fibrinogen, vimentin and collagen.\nsynonyms :\n'}


{'id': 'HP_0033035', 'url': 'http://purl.obolibrary.org/obo/HP_0033035', 'lbl': 'Abnormal Schwann cell morphology', 'desc': 'label: Abnormal Schwann cell morphology\ndefinition : Abnormality of schwann cells, glial cells that ensheath axons of neurons in the peripheral nervous system and are necessary for their maintenance and function.\nsynonyms :Abnormal neurilemmal cell morphology; Abnormal neurilemmocyte morphology\n'}


{'id': 'HP_0033036', 'url': 'http://purl.obolibrary.org/obo/HP_0033036', 'lbl': 'Decreased nasal nitric oxide', 'desc': 'label: Decreased nasal nitric oxide\ndefinition : Reduced level of nasal nitric oxide (nNO). Current American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines for nNO measurements recommend air aspiration via a nasal probe while the subject exhales through the mouth against resistance in order to maintain velum closure.\nsynonyms :Low nasal nitric oxide level\n'}


{'id': 'HP_0033037', 'url': 'http://purl.obolibrary.org/obo/HP_0033037', 'lbl': 'Migratory arthritis', 'desc': 'label: Migratory arthritis\ndefinition : \nsynonyms :Migratory polyarthritis\n'}


{'id': 'HP_0033038', 'url': 'http://purl.obolibrary.org/obo/HP_0033038', 'lbl': 'Anti-RNA-polymerase-III-autoantibody positivity', 'desc': 'label: Anti-RNA-polymerase-III-autoantibody positivity\ndefinition : The presence of autoantibodies in the serum that react to RNA-polymerase III.\nsynonyms :\n'}


{'id': 'HP_0033039', 'url': 'http://purl.obolibrary.org/obo/HP_0033039', 'lbl': 'Increased circulating precipitin level', 'desc': 'label: Increased circulating precipitin level\ndefinition : The presence of high titers of antigen-precipitating IgG in the serum.\nsynonyms :Increased level of antigen-precipitating IgG antibodies\n'}


{'id': 'HP_0033040', 'url': 'http://purl.obolibrary.org/obo/HP_0033040', 'lbl': 'Anti-Sm antibody positivity', 'desc': 'label: Anti-Sm antibody positivity\ndefinition : The presence of autoantibodies in the serum that react to seven proteins that consist of a core of small nuclear ribonucleoprotein (snRNP) particles.\nsynonyms :Anti-Smith autoantibody\n'}


{'id': 'HP_0033041', 'url': 'http://purl.obolibrary.org/obo/HP_0033041', 'lbl': 'Cytokine storm', 'desc': 'label: Cytokine storm\ndefinition : Excessive or uncontrolled release of proinflammatory cytokines.\nsynonyms :Hypercytokinemia\n'}


{'id': 'HP_0033042', 'url': 'http://purl.obolibrary.org/obo/HP_0033042', 'lbl': 'Abnormal chorion morphology', 'desc': 'label: Abnormal chorion morphology\ndefinition : Any structural anomaly of the fetal part of the placenta, which is known as the chorion.\nsynonyms :\n'}


{'id': 'HP_0033043', 'url': 'http://purl.obolibrary.org/obo/HP_0033043', 'lbl': 'Edematous chorionic villi', 'desc': 'label: Edematous chorionic villi\ndefinition : Swelling of the chorionic villi owing to fluid accumulation.\nsynonyms :\n'}


{'id': 'HP_0033044', 'url': 'http://purl.obolibrary.org/obo/HP_0033044', 'lbl': 'Motor regression', 'desc': 'label: Motor regression\ndefinition : Loss of previously achieved motor skills, as manifested by loss of developmental motor milestones.\nsynonyms :Regression of motor skills\n'}


{'id': 'HP_0033045', 'url': 'http://purl.obolibrary.org/obo/HP_0033045', 'lbl': 'Bipedal edema', 'desc': 'label: Bipedal edema\ndefinition : A palpable swelling in both feet and ankles caused by an increase in interstitial fluid volume (excess fluid).\nsynonyms :Bipedal oedema\n'}


{'id': 'HP_0033046', 'url': 'http://purl.obolibrary.org/obo/HP_0033046', 'lbl': 'Michaelis-Gutmann bodies', 'desc': 'label: Michaelis-Gutmann bodies\ndefinition : Basophilic intracytoplasmic inclusions in macrophages. The inclusions have a small, round laminated appearance. Electron microscopy of Michaelis-Gutmann bodies exhibits partially digested bacteria.\nsynonyms :Malakoplakia\n'}


{'id': 'HP_0033047', 'url': 'http://purl.obolibrary.org/obo/HP_0033047', 'lbl': 'Body ache', 'desc': 'label: Body ache\ndefinition : Body ache is a complaint that is often used to denote vague symptoms of mild fatigue, lethargy, or dull aches. We will define it here to mean a dull and poorly localizable pain that is described by the affected individual to affect multiple joints or body parts or even the entire body.\nsynonyms :\n'}


{'id': 'HP_0033048', 'url': 'http://purl.obolibrary.org/obo/HP_0033048', 'lbl': 'Substantia nigra hypointensity on susceptibility-weighted imaging', 'desc': 'label: Substantia nigra hypointensity on susceptibility-weighted imaging\ndefinition : Hypointence (dark) appearance of the substantia nigra inmagnetic resonance imaging using susceptibility weighted imaging (SWI).\nsynonyms :Low signal intensity in the substantia nigra on susceptibility-weighted imaging (SWI)\n'}


{'id': 'HP_0033049', 'url': 'http://purl.obolibrary.org/obo/HP_0033049', 'lbl': 'Globus pallidus hypointensity on susceptibility-weighted imaging', 'desc': 'label: Globus pallidus hypointensity on susceptibility-weighted imaging\ndefinition : Hypointence (dark) appearance of the globus pallidus inmagnetic resonance imaging using susceptibility weighted imaging (SWI).\nsynonyms :\n'}


{'id': 'HP_0033050', 'url': 'http://purl.obolibrary.org/obo/HP_0033050', 'lbl': 'Pharyngalgia', 'desc': 'label: Pharyngalgia\ndefinition : An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the throat.\nsynonyms :Pharyngodynia; Sore throat; Throat discomfort; Throat pain\n'}


{'id': 'HP_0033051', 'url': 'http://purl.obolibrary.org/obo/HP_0033051', 'lbl': 'Impaired executive functioning', 'desc': 'label: Impaired executive functioning\ndefinition : A disturbance of executive functioning, which is broadly defined as the set of abilities that allow for the planning, executing, monitoring, and self-correcting of goal-directed behavior while inhibiting task-irrelevant behavior. At least some degree of executive skill is needed to complete most cognitive tasks, and deficits in executive abilities are central to many clinical conditions, including fronto-temporal dementia.\nsynonyms :\n'}


{'id': 'HP_0033052', 'url': 'http://purl.obolibrary.org/obo/HP_0033052', 'lbl': 'Psychogenic non-epileptic seizure', 'desc': 'label: Psychogenic non-epileptic seizure\ndefinition : Psychogenic non-epileptic seizures (PNES) are an important cause of apparently treatment-resistant epilepsy and remain a major diagnostic challenge in epileptology. The two main PNES groups are panic disorder (also occurring as a reaction in people with epilepsy) and dissociative disorder (pseudoseizure), often developing inpatients with no history of epilepsy. The main markers distinguishing PNES from epileptic seizures are (i) the way the patient tells the story (not focusing on the seizure symptoms, avoidance of the word seizure, etc); (ii) that they are prolonged (many minutes); (iii) associated with hyperventilation and eyes closed; and that they present as treatment-resistant epilepsy despite an often normal intellect and brain imaging.\nsynonyms :\n'}


{'id': 'HP_0033053', 'url': 'http://purl.obolibrary.org/obo/HP_0033053', 'lbl': 'Pseudoseizure', 'desc': 'label: Pseudoseizure\ndefinition : Sudden, involuntary seizure-like attacks that, unlike epileptic seizures, are not related to electrographic ictal discharges.\nsynonyms :\n'}


{'id': 'HP_0033054', 'url': 'http://purl.obolibrary.org/obo/HP_0033054', 'lbl': 'Myoclonic tremor', 'desc': 'label: Myoclonic tremor\ndefinition : A tremor-like cortical myoclonus. The tremulous movements are in fact small, high-frequency myoclonic jerks, induced by posture or action. They can be mild, but can also be more incapacitating. When present in the lower limbs, these may lead to gait disorders and even drop attacks. These tremor-like movements during action can be mistaken for essential tremor or epileptic seizures.\nsynonyms :\n'}


{'id': 'HP_0033055', 'url': 'http://purl.obolibrary.org/obo/HP_0033055', 'lbl': 'Impaired ability to plan', 'desc': 'label: Impaired ability to plan\ndefinition : Impaired ability to anticipate future events, implement instructions or goals, and develop appropriate steps ahead of time in order to carry out a task or activity.\nsynonyms :Ineffective planning\n'}


{'id': 'HP_0033056', 'url': 'http://purl.obolibrary.org/obo/HP_0033056', 'lbl': 'Impaired ability to organize', 'desc': 'label: Impaired ability to organize\ndefinition : Impaired ability to bring order to information, actions, or materials to achieve a goal or to follow an established organized routine.\nsynonyms :Impaired ability to organise\n'}


{'id': 'HP_0033057', 'url': 'http://purl.obolibrary.org/obo/HP_0033057', 'lbl': 'Decreased circulating terminal complement component concentration', 'desc': 'label: Decreased circulating terminal complement component concentration\ndefinition : Concentration below the lower limit of normal of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components: C5b, C6, C7, C8 (a heterotrimer composed of C8alpha, C8beta and C8gamma) and multiple copies of C9.\nsynonyms :Decreased serum terminal complement component\n'}


{'id': 'HP_0033058', 'url': 'http://purl.obolibrary.org/obo/HP_0033058', 'lbl': 'Decreased circulating complement C7 concentration', 'desc': 'label: Decreased circulating complement C7 concentration\ndefinition : Concentration of the complement component C7 in the blood circulation below the lower limit of normal.\nsynonyms :Decreased serum complement C7\n'}


{'id': 'HP_0033059', 'url': 'http://purl.obolibrary.org/obo/HP_0033059', 'lbl': 'Decreased circulating complement C6 concentration', 'desc': 'label: Decreased circulating complement C6 concentration\ndefinition : Concentration of the complement component C6 in the blood circulation below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0033060', 'url': 'http://purl.obolibrary.org/obo/HP_0033060', 'lbl': 'Decreased circulating complement C5 concentration', 'desc': 'label: Decreased circulating complement C5 concentration\ndefinition : Concentration of the complement component C5 in the blood circulation below the lower limit of normal.\nsynonyms :Decreased serum complement C5\n'}


{'id': 'HP_0033061', 'url': 'http://purl.obolibrary.org/obo/HP_0033061', 'lbl': 'Increased factor IX activity', 'desc': 'label: Increased factor IX activity\ndefinition : Elevated activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.\nsynonyms :\n'}


{'id': 'HP_0033062', 'url': 'http://purl.obolibrary.org/obo/HP_0033062', 'lbl': 'Abnormal factor IX activity', 'desc': 'label: Abnormal factor IX activity\ndefinition : Abnormal activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.\nsynonyms :\n'}


{'id': 'HP_0033063', 'url': 'http://purl.obolibrary.org/obo/HP_0033063', 'lbl': 'Shortened sleep cycle', 'desc': 'label: Shortened sleep cycle\ndefinition : A tendency to sleep less hours than usual while feeling well rested.\nsynonyms :Short sleep\n'}


{'id': 'HP_0033064', 'url': 'http://purl.obolibrary.org/obo/HP_0033064', 'lbl': 'Renal interstitial globotriaosylceramide inclusions', 'desc': 'label: Renal interstitial globotriaosylceramide inclusions\ndefinition : Accumulation of globotriaosylceramide (GL-3) in kidney tissues, which can be quantified as the number of globotriaosylceramide (GL-3) inclusions/kidney interstitial capillary (KIC).\nsynonyms :\n'}


{'id': 'HP_0033065', 'url': 'http://purl.obolibrary.org/obo/HP_0033065', 'lbl': 'Mild albuminuria', 'desc': 'label: Mild albuminuria\ndefinition : The presence of mildly increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio (ACR) less than 30 mg/gm (less than 3.4 mg/mmol).\nsynonyms :\n'}


{'id': 'HP_0033066', 'url': 'http://purl.obolibrary.org/obo/HP_0033066', 'lbl': 'Severe albuminuria', 'desc': 'label: Severe albuminuria\ndefinition : The presence of severely increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio greater than 300 mg/gm (greater than 34 mg/mmol).\nsynonyms :Heavy albuminuria\n'}


{'id': 'HP_0033067', 'url': 'http://purl.obolibrary.org/obo/HP_0033067', 'lbl': 'Cystine crystalluria', 'desc': 'label: Cystine crystalluria\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0033068', 'url': 'http://purl.obolibrary.org/obo/HP_0033068', 'lbl': 'Medication crystalluria', 'desc': "label: Medication crystalluria\ndefinition : A variety of drugs may occasionally cause transient crystalluria, in isolation or in conjunction with other urinary abnormalities. Overdose, dehydration, or hypoalbuminaemia, which increases the unbound drug which is ultrafiltrated by the glomerulus, are the factors usally favoring the precipitation of crystals within the tubular lumina. In some cases, medication-induced crystalluria has a distinct phenotypic appearance. For instance, Sulphadiazine crystals appear as strongly birefringent 'shocks of wheat' or 'shells' with an amber colour. Acyclovir crystals are birefringent and needle-shaped, and when present in abundance give to urine a silky and opalescent macroscopic appearance.\nsynonyms :\n"}


{'id': 'HP_0033069', 'url': 'http://purl.obolibrary.org/obo/HP_0033069', 'lbl': 'Renal interstitial IgG4+ plasma cell infiltration', 'desc': 'label: Renal interstitial IgG4+ plasma cell infiltration\ndefinition : An increased number of IgG4+ plasma cells in the interstitial space of the kidney.\nsynonyms :\n'}


{'id': 'HP_0033070', 'url': 'http://purl.obolibrary.org/obo/HP_0033070', 'lbl': 'Impaired self monitoring', 'desc': "label: Impaired self monitoring\ndefinition : Impaired ability to track awareness of the effect that one's behavior has on others and how it compares with standards or expectations for behavior.\nsynonyms :\n"}


{'id': 'HP_0033071', 'url': 'http://purl.obolibrary.org/obo/HP_0033071', 'lbl': 'Impaired task monitoring', 'desc': "label: Impaired task monitoring\ndefinition : Impaired ability to keep track of one's problem-solving success or failure, and to identify and correct mistakes during performance of a goal.\nsynonyms :\n"}


{'id': 'HP_0033072', 'url': 'http://purl.obolibrary.org/obo/HP_0033072', 'lbl': 'Abnormal macroscopic urine appearance', 'desc': 'label: Abnormal macroscopic urine appearance\ndefinition : Anomalous physical appearance (color, cloudiness, clarity) or odor of urine.\nsynonyms :\n'}


{'id': 'HP_0033073', 'url': 'http://purl.obolibrary.org/obo/HP_0033073', 'lbl': 'Urate tophus', 'desc': 'label: Urate tophus\ndefinition : Intradermal urate crystal deposits appeared as small, superficial, pustule-like, whitish lesions. The lesions may be the focus of inflammatory episodes with increasing pain, swelling, and erythema of the intradermal tophi.\nsynonyms :Urate tophi\n'}


{'id': 'HP_0033074', 'url': 'http://purl.obolibrary.org/obo/HP_0033074', 'lbl': 'Steroid-responsive anemia', 'desc': 'label: Steroid-responsive anemia\ndefinition : Amelioration of anemia upon treatment with a steroid medication.\nsynonyms :Prednisone-responsive anaemia; Prednisone-responsive anemia; Steroid-responsive anaemia\n'}


{'id': 'HP_0033075', 'url': 'http://purl.obolibrary.org/obo/HP_0033075', 'lbl': 'Inappropriately normal thyroid-stimulating hormone level', 'desc': 'label: Inappropriately normal thyroid-stimulating hormone level\ndefinition : A normal or elevated serum thyroid-stimulating hormone (TSH) level in the face of an elevation in circulating FT4 and/or FT3.\nsynonyms :Inappropriately normal TSH\n'}


{'id': 'HP_0033076', 'url': 'http://purl.obolibrary.org/obo/HP_0033076', 'lbl': 'Abnormal circulating free T4 concentration', 'desc': 'label: Abnormal circulating free T4 concentration\ndefinition : A deviation from the normal concentration of free thyroxine (T4) in the blood circulation. Circulating T4 is almost entirely bound to specific transport proteins such as thyroxine-binding globulin (TBG) but it is the unbound (free) fraction that is able to enter tissues and exert effects.\nsynonyms :Abnormal circulating free T4 level; Abnormal circulating free thyroxine level\n'}


{'id': 'HP_0033077', 'url': 'http://purl.obolibrary.org/obo/HP_0033077', 'lbl': 'Increased circulating free T4 concentration', 'desc': 'label: Increased circulating free T4 concentration\ndefinition : An elevated concentration of free thyroxine (fT4) in the blood circulation.\nsynonyms :Increased circulating free T4 level\n'}


{'id': 'HP_0033078', 'url': 'http://purl.obolibrary.org/obo/HP_0033078', 'lbl': 'Decreased circulating free T4 concentration', 'desc': 'label: Decreased circulating free T4 concentration\ndefinition : A reduced concentration of free thyroxine (fT4) in the blood circulation.\nsynonyms :Decreased circulating free T4 level\n'}


{'id': 'HP_0033079', 'url': 'http://purl.obolibrary.org/obo/HP_0033079', 'lbl': 'Aplasia/Hypoplasia of the thyroid gland', 'desc': 'label: Aplasia/Hypoplasia of the thyroid gland\ndefinition : Absence or underdevelopment of the thyroid gland.\nsynonyms :\n'}


{'id': 'HP_0033080', 'url': 'http://purl.obolibrary.org/obo/HP_0033080', 'lbl': 'Abnormal TSH response to thyrotrophin-releasing hormone stimulation test', 'desc': 'label: Abnormal TSH response to thyrotrophin-releasing hormone stimulation test\ndefinition : Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide synthesised by, stored within and released from the hypothalamus. It stimulates the synthesis and release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. Following administration of exogenous TRH, a transient increase in serum TSH is expected. This term refers to an abnormal reponse in the TRH stimulation test.\nsynonyms :Abnormal TSH response to TRH stimulation test\n'}


{'id': 'HP_0033081', 'url': 'http://purl.obolibrary.org/obo/HP_0033081', 'lbl': 'Absent TSH response to thyrotrophin-releasing hormone stimulation test', 'desc': 'label: Absent TSH response to thyrotrophin-releasing hormone stimulation test\ndefinition : Failure to increase serum TSH levels in response to a TRH stimulation test.\nsynonyms :\n'}


{'id': 'HP_0033082', 'url': 'http://purl.obolibrary.org/obo/HP_0033082', 'lbl': 'Reduced TSH response to thyrotrophin-releasing hormone stimulation test', 'desc': 'label: Reduced TSH response to thyrotrophin-releasing hormone stimulation test\ndefinition : A lower than normal TSH response to thyrotrophin-releasing hormone stimulation test.\nsynonyms :\n'}


{'id': 'HP_0033083', 'url': 'http://purl.obolibrary.org/obo/HP_0033083', 'lbl': 'Increased circulating farnesol concentration', 'desc': 'label: Increased circulating farnesol concentration\ndefinition : An elevated level of farnesol in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033084', 'url': 'http://purl.obolibrary.org/obo/HP_0033084', 'lbl': 'Abnormal antral follicle count', 'desc': 'label: Abnormal antral follicle count\ndefinition : Any deviation from a count of antral follicles that is normal for age. Antral follicles appear as small fluid-filled sacs that contain an immature egg. Antral follicle count can be measured (usually on day 2-5 of the menstrual cycle) by transvaginal ultrasound. The number of antral follicles may reflect ovarian reserve.\nsynonyms :\n'}


{'id': 'HP_0033085', 'url': 'http://purl.obolibrary.org/obo/HP_0033085', 'lbl': 'Reduced antral follicle count', 'desc': 'label: Reduced antral follicle count\ndefinition : A count of antral follicles that is lower than normal for age.\nsynonyms :\n'}


{'id': 'HP_0033086', 'url': 'http://purl.obolibrary.org/obo/HP_0033086', 'lbl': 'Increased antral follicle count', 'desc': 'label: Increased antral follicle count\ndefinition : A count of antral follicles that is higher than normal for age.\nsynonyms :\n'}


{'id': 'HP_0033087', 'url': 'http://purl.obolibrary.org/obo/HP_0033087', 'lbl': 'Quotidian fever', 'desc': 'label: Quotidian fever\ndefinition : Fever that occurs at daily intervals.\nsynonyms :\n'}


{'id': 'HP_0033088', 'url': 'http://purl.obolibrary.org/obo/HP_0033088', 'lbl': 'Valinuria', 'desc': 'label: Valinuria\ndefinition : Urine valine level above the normal range.\nsynonyms :Increased valine in urine\n'}


{'id': 'HP_0033089', 'url': 'http://purl.obolibrary.org/obo/HP_0033089', 'lbl': 'Branched-chain aminoaciduria', 'desc': 'label: Branched-chain aminoaciduria\ndefinition : An increased level of a branched chain family amino acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033090', 'url': 'http://purl.obolibrary.org/obo/HP_0033090', 'lbl': 'Increased aromatic amino acid level in urine', 'desc': 'label: Increased aromatic amino acid level in urine\ndefinition : An elevated level of an aromatic amino acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033091', 'url': 'http://purl.obolibrary.org/obo/HP_0033091', 'lbl': 'Tyrosinuria', 'desc': 'label: Tyrosinuria\ndefinition : An abnormally increased level of tyrosine in the urine.\nsynonyms :Increased tyrosine in urine\n'}


{'id': 'HP_0033092', 'url': 'http://purl.obolibrary.org/obo/HP_0033092', 'lbl': 'Increased urine succinate level', 'desc': 'label: Increased urine succinate level\ndefinition : An increase in the level of succinate in the urine.\nsynonyms :\n'}


{'id': 'HP_0033093', 'url': 'http://purl.obolibrary.org/obo/HP_0033093', 'lbl': 'Increased glutamine family amino acid level in urine', 'desc': 'label: Increased glutamine family amino acid level in urine\ndefinition : An elevated level of an glutamine family amino acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033094', 'url': 'http://purl.obolibrary.org/obo/HP_0033094', 'lbl': 'Increased urine glutamate level', 'desc': 'label: Increased urine glutamate level\ndefinition : An increased concentration of glutamate in the urine.\nsynonyms :Increased glutamic acid in urine\n'}


{'id': 'HP_0033095', 'url': 'http://purl.obolibrary.org/obo/HP_0033095', 'lbl': 'Increased sulfur amino acid level in urine', 'desc': 'label: Increased sulfur amino acid level in urine\ndefinition : An elevated level of a sulfur-containing amino acid in the urine.\nsynonyms :Increased sulfur-containing amino acid level in urine; Increased sulphur amino acid level in urine\n'}


{'id': 'HP_0033096', 'url': 'http://purl.obolibrary.org/obo/HP_0033096', 'lbl': 'Increased aspartate family amino acid level in urine', 'desc': 'label: Increased aspartate family amino acid level in urine\ndefinition : An elevated level of an aspartate family amino acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033097', 'url': 'http://purl.obolibrary.org/obo/HP_0033097', 'lbl': 'Increased urine proteinogenic amino acid derivative level', 'desc': 'label: Increased urine proteinogenic amino acid derivative level\ndefinition : An elevated urine level of a compound that is derived from an amino acid.\nsynonyms :\n'}


{'id': 'HP_0033098', 'url': 'http://purl.obolibrary.org/obo/HP_0033098', 'lbl': 'Increased urinary non-proteinogenic amino acid level', 'desc': 'label: Increased urinary non-proteinogenic amino acid level\ndefinition : An increased level in the urine of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.\nsynonyms :Elevated urinary non-proteinogenic amino acid level\n'}


{'id': 'HP_0033099', 'url': 'http://purl.obolibrary.org/obo/HP_0033099', 'lbl': 'Increased serine family amino acid in urine', 'desc': 'label: Increased serine family amino acid in urine\ndefinition : An increased level of a serine family amino acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033100', 'url': 'http://purl.obolibrary.org/obo/HP_0033100', 'lbl': 'Increased proteinogenic amino acid level in urine', 'desc': 'label: Increased proteinogenic amino acid level in urine\ndefinition : An elevated level of a proteinogenic amino acid in the urine. These are the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine.\nsynonyms :\n'}


{'id': 'HP_0033101', 'url': 'http://purl.obolibrary.org/obo/HP_0033101', 'lbl': 'Elevated urine aconitic acid level', 'desc': 'label: Elevated urine aconitic acid level\ndefinition : An abnormally increased level of aconitic acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0033102', 'url': 'http://purl.obolibrary.org/obo/HP_0033102', 'lbl': 'Monkey wrench femoral neck', 'desc': 'label: Monkey wrench femoral neck\ndefinition : The femoral neck region shows medial metaphyseal beaking and a significant enlargement of the lesser trochanter (with some enlargement also of the greater trochanter), producing a monkey wrench (Swedish key) configuration of the proximal femur. A monkey wrench refers to a type of adjustable wrench with one fixed and one adjustable jaw at right angles to a straight handle.\nsynonyms :Monkey wrench appearance of femoral neck; Monkey wrench configuration of the proximal femur; Swedish key appearance of femoral neck; Swedish key configuration of the proximal femur\n'}


{'id': 'HP_0033103', 'url': 'http://purl.obolibrary.org/obo/HP_0033103', 'lbl': 'Elevated circulating CHI3L1 level', 'desc': 'label: Elevated circulating CHI3L1 level\ndefinition : Increased concentration of chitinase 3-like 1 (CHI3L1) in the blood circulation.\nsynonyms :Elevated circulating YKL40 level; Elevated circulating chitinase 3-like 1 level\n'}


{'id': 'HP_0033104', 'url': 'http://purl.obolibrary.org/obo/HP_0033104', 'lbl': 'Inappropriate absence of fever', 'desc': 'label: Inappropriate absence of fever\ndefinition : Failure to develop fever in the presence of an infection that normally would be expected to elicit a febrile response.\nsynonyms :\n'}


{'id': 'HP_0033105', 'url': 'http://purl.obolibrary.org/obo/HP_0033105', 'lbl': 'Interhypothalamic adhesion', 'desc': 'label: Interhypothalamic adhesion\ndefinition : An abnormal parenchymal band connecting the medial margins of the left and right hypothalami across the third ventricle.\nsynonyms :Hypothalamic adhesion\n'}


{'id': 'HP_0033106', 'url': 'http://purl.obolibrary.org/obo/HP_0033106', 'lbl': 'Elevated circulating D-dimer concentration', 'desc': 'label: Elevated circulating D-dimer concentration\ndefinition : An increased concentration of D-dimers, a marker of fibrin degradation, in the blood circulation.\nsynonyms :Elevated D-dimers; Elevated fibrin degradation fragment concentration\n'}


{'id': 'HP_0033107', 'url': 'http://purl.obolibrary.org/obo/HP_0033107', 'lbl': 'Abnormal circulating proteinogenic amino acid concentration', 'desc': 'label: Abnormal circulating proteinogenic amino acid concentration\ndefinition : An elevated level of a proteinogenic amino acid in the blood circulation. These are the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine.\nsynonyms :\n'}


{'id': 'HP_0033108', 'url': 'http://purl.obolibrary.org/obo/HP_0033108', 'lbl': 'Abnormal circulating proteinogenic amino acid derivative concentration', 'desc': 'label: Abnormal circulating proteinogenic amino acid derivative concentration\ndefinition : Any deviation from the normal concentration in the blood circulation of a compound that is derived from an amino acid.\nsynonyms :\n'}


{'id': 'HP_0033109', 'url': 'http://purl.obolibrary.org/obo/HP_0033109', 'lbl': 'Abnormal circulating non-proteinogenic amino acid concentration', 'desc': 'label: Abnormal circulating non-proteinogenic amino acid concentration\ndefinition : Any deviation from the normal concentration in the blood circulation of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.\nsynonyms :\n'}


{'id': 'HP_0033110', 'url': 'http://purl.obolibrary.org/obo/HP_0033110', 'lbl': 'Elevated circulating alpha-aminobutyric acid concentration', 'desc': 'label: Elevated circulating alpha-aminobutyric acid concentration\ndefinition : An abnormally increased level of alpa-aminobutyric acid in the blood circulation. Alpha-aminobutyric acid alpha-amino acid that is butyric acid bearing a single amino substituent located at position 2.\nsynonyms :Elevated circulating homoalanine concentration\n'}


{'id': 'HP_0033111', 'url': 'http://purl.obolibrary.org/obo/HP_0033111', 'lbl': '3-hydroxyisovaleric aciduria', 'desc': 'label: 3-hydroxyisovaleric aciduria\ndefinition : Concentration of 3-hydroxyisovaleric acid in the urine above the normal range.\nsynonyms :Increased urine 3-hydroxyisovaleric acid level\n'}


{'id': 'HP_0033112', 'url': 'http://purl.obolibrary.org/obo/HP_0033112', 'lbl': 'Elevated circulating apolipoprotein C-III concentration', 'desc': 'label: Elevated circulating apolipoprotein C-III concentration\ndefinition : An increased concentration in blood of apolipoprotein C-III, a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons.\nsynonyms :Elevated APOC3 level; Elevated apolipoprotein C-III level\n'}


{'id': 'HP_0033113', 'url': 'http://purl.obolibrary.org/obo/HP_0033113', 'lbl': 'Gallop rhythm', 'desc': 'label: Gallop rhythm\ndefinition : In the normal heart cycle, two heart sounds can be heard by auscultation per cycle: S1 and S2. A gallop rhythm refers to the presence of three or four heart sounds per cardiac cycle, which is said to resemble the gallop of a horse.\nsynonyms :Triple rhythm\n'}


{'id': 'HP_0033114', 'url': 'http://purl.obolibrary.org/obo/HP_0033114', 'lbl': 'Quadruple gallop rhythm', 'desc': 'label: Quadruple gallop rhythm\ndefinition : A type of gallop rhytm in which both the third and the fourth sounds are present.\nsynonyms :\n'}


{'id': 'HP_0033115', 'url': 'http://purl.obolibrary.org/obo/HP_0033115', 'lbl': 'Elevated circulating tenascin-C level', 'desc': 'label: Elevated circulating tenascin-C level\ndefinition : Abnormally increased concentration of tenascin-C in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033116', 'url': 'http://purl.obolibrary.org/obo/HP_0033116', 'lbl': 'Duodenal gastric metaplasia', 'desc': 'label: Duodenal gastric metaplasia\ndefinition : Foci of gastric-type mucus-secreting cells interspersed between duodenal enterocytes. These foci of gastric epithelial cells contain Periodic acid-Schiff (PAS)-positive neutral mucin and lack a brush border.\nsynonyms :\n'}


{'id': 'HP_0033117', 'url': 'http://purl.obolibrary.org/obo/HP_0033117', 'lbl': 'Duodenitis', 'desc': 'label: Duodenitis\ndefinition : Inflammation of the lining of the upper small intestine (duodenum).\nsynonyms :Duodenal inflammation\n'}


{'id': 'HP_0033118', 'url': 'http://purl.obolibrary.org/obo/HP_0033118', 'lbl': 'Abnormal right ventricular function', 'desc': 'label: Abnormal right ventricular function\ndefinition : Anomalous physiology (function) of the right ventricle.\nsynonyms :\n'}


{'id': 'HP_0033119', 'url': 'http://purl.obolibrary.org/obo/HP_0033119', 'lbl': 'Elevated right ventricular systolic pressure', 'desc': 'label: Elevated right ventricular systolic pressure\ndefinition : Elevation of right ventricular systolic pressure (RVSP) above normal limits. In adults, RVSP is normally 20-30 mmHg.\nsynonyms :\n'}


{'id': 'HP_0033120', 'url': 'http://purl.obolibrary.org/obo/HP_0033120', 'lbl': 'Nummular eczema', 'desc': 'label: Nummular eczema\ndefinition : A type of eczema characterized by pruritic coin-shaped patches on the skin. Nummular eczema most commonly occurs on the extremities, particularly the legs, but may occur anywhere on the trunk, hands, or feet\nsynonyms :Discoid eczema; Nummular dermatitis\n'}


{'id': 'HP_0033121', 'url': 'http://purl.obolibrary.org/obo/HP_0033121', 'lbl': 'Barking cough', 'desc': "label: Barking cough\ndefinition : A cough with a characteristic sound that has been compared to a seal's bark.\nsynonyms :Seal-like barking cough\n"}


{'id': 'HP_0033122', 'url': 'http://purl.obolibrary.org/obo/HP_0033122', 'lbl': 'Absent P wave', 'desc': 'label: Absent P wave\ndefinition : The P wave that normally precedes each QRS complex by a fixed PR interval of 120 to 200 milliseconds is not present.\nsynonyms :Absence of P wave on electrocardiography\n'}


{'id': 'HP_0033123', 'url': 'http://purl.obolibrary.org/obo/HP_0033123', 'lbl': 'Elevated circulating osteopontin level', 'desc': 'label: Elevated circulating osteopontin level\ndefinition : Abnormally increased level of osteopontin in the blood circulation\nsynonyms :\n'}


{'id': 'HP_0033124', 'url': 'http://purl.obolibrary.org/obo/HP_0033124', 'lbl': 'Increased serum sorbitol concentration', 'desc': 'label: Increased serum sorbitol concentration\ndefinition : An increased level of sorbitol in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033125', 'url': 'http://purl.obolibrary.org/obo/HP_0033125', 'lbl': 'Follicular lymphoma', 'desc': 'label: Follicular lymphoma\ndefinition : An indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement.\nsynonyms :\n'}


{'id': 'HP_0033126', 'url': 'http://purl.obolibrary.org/obo/HP_0033126', 'lbl': 'Cutaneous necrosis', 'desc': 'label: Cutaneous necrosis\ndefinition : Skin and subcutaneous tissue necrosis (tissue death). Clinically, cutaneous necrosis may present as a painful and extremely tender black eschar (dead tissue found in a full-thickness wound) surrounded by dusky grey-red coloured skin.\nsynonyms :Skin necrosis\n'}


{'id': 'HP_0033127', 'url': 'http://purl.obolibrary.org/obo/HP_0033127', 'lbl': 'Abnormality of the musculoskeletal system', 'desc': 'label: Abnormality of the musculoskeletal system\ndefinition : An anomaly of the musculoskeletal system, which consists of the bones of the skeleton, muscles, cartilage, tendons, ligaments, joints, and other connective tissue. The musculoskeletal system supports the weight of the body, maintains body position and produces movements of the body or of parts of the body.\nsynonyms :\n'}


{'id': 'HP_0033128', 'url': 'http://purl.obolibrary.org/obo/HP_0033128', 'lbl': 'Delayed ability to crawl', 'desc': 'label: Delayed ability to crawl\ndefinition : A failure to achieve the ability to crawl at an appropriate developmental stage. Normal infant motor development is marked by a series of postural milestones including learning to crawl on hands and knees between the ages of 6 and 10 months.\nsynonyms :\n'}


{'id': 'HP_0033129', 'url': 'http://purl.obolibrary.org/obo/HP_0033129', 'lbl': 'Abnormal shoulder physiology', 'desc': 'label: Abnormal shoulder physiology\ndefinition : Anopmalous function of the shoulder. The shoulder is a ball-and-socket joint that is made up of humerus, scapula and clavicle, which are connected by the sternoclavicular joint (SC), the acromioclavicular joint (AC), the glenohumeral joint (GH), and the scapulothoracic joint (ST). The GH, AC and SC joints link the upper extremity to the axial skeleton at the thorax and enable movement at the shoulder joint: flexion, extension, and rotation of the arm.\nsynonyms :\n'}


{'id': 'HP_0033130', 'url': 'http://purl.obolibrary.org/obo/HP_0033130', 'lbl': 'Abnormal renal echogenicity', 'desc': 'label: Abnormal renal echogenicity\ndefinition : Anomalous echogenicity of the kidney on ultrasound examination.\nsynonyms :\n'}


{'id': 'HP_0033131', 'url': 'http://purl.obolibrary.org/obo/HP_0033131', 'lbl': 'Renal medullary hyperechogenicity', 'desc': 'label: Renal medullary hyperechogenicity\ndefinition : Increased echogenecity of the medullary region of the kidney.\nsynonyms :Increased renal medullary echogenicity\n'}


{'id': 'HP_0033132', 'url': 'http://purl.obolibrary.org/obo/HP_0033132', 'lbl': 'Renal cortical hyperechogenicity', 'desc': 'label: Renal cortical hyperechogenicity\ndefinition : Increased echogenecity of the kidney cortex.\nsynonyms :\n'}


{'id': 'HP_0033133', 'url': 'http://purl.obolibrary.org/obo/HP_0033133', 'lbl': 'Renal cortical hypoechogeneity', 'desc': 'label: Renal cortical hypoechogeneity\ndefinition : \nsynonyms :Hypoechogenic renal cortex\n'}


{'id': 'HP_0033134', 'url': 'http://purl.obolibrary.org/obo/HP_0033134', 'lbl': 'Abdominal adhesions', 'desc': 'label: Abdominal adhesions\ndefinition : Fibrous bands (i.e., bands of scar-like tissue) that span two or more intra-abdominal organs and/or the inner abdominal wall (i.e. peritoneal membrane).\nsynonyms :Intra-abdominal adhesion\n'}


{'id': 'HP_0033135', 'url': 'http://purl.obolibrary.org/obo/HP_0033135', 'lbl': 'Hepatic infarction', 'desc': 'label: Hepatic infarction\ndefinition : Hepatic infarction is defined as areas of coagulative necrosis from hepatocyte cell death caused by local ischemia. Liver infarctions appear as hypoechoic nonvascular regions on conventional and Doppler sonography.\nsynonyms :\n'}


{'id': 'HP_0033136', 'url': 'http://purl.obolibrary.org/obo/HP_0033136', 'lbl': 'Lymph node abscess', 'desc': 'label: Lymph node abscess\ndefinition : An inflammed lymph node that is filled with pus.\nsynonyms :\n'}


{'id': 'HP_0033137', 'url': 'http://purl.obolibrary.org/obo/HP_0033137', 'lbl': 'Abnormal pulmonary alveolar system morphology', 'desc': 'label: Abnormal pulmonary alveolar system morphology\ndefinition : A structural abnormality of the pulmonary acinus, alveolar parenchyma, or alveoli.\nsynonyms :\n'}


{'id': 'HP_0033138', 'url': 'http://purl.obolibrary.org/obo/HP_0033138', 'lbl': 'Right atrial thrombus', 'desc': 'label: Right atrial thrombus\ndefinition : A thrombus (i.e., a blood clot formed in situ within the vascular system) located in the right atrium of the heart.\nsynonyms :\n'}


{'id': 'HP_0033139', 'url': 'http://purl.obolibrary.org/obo/HP_0033139', 'lbl': 'Elevated circulating uracil concentration', 'desc': 'label: Elevated circulating uracil concentration\ndefinition : Concentration of uracil in the blood circulation is above the normal range.\nsynonyms :\n'}


{'id': 'HP_0033140', 'url': 'http://purl.obolibrary.org/obo/HP_0033140', 'lbl': "Blake's pouch cyst", 'desc': "label: Blake's pouch cyst\ndefinition : The presence of an upwardly displaced normal cerebellar vermis, normal appearance of the fastigium, tentorium and size of the cisterna magna.\nsynonyms :\n"}


{'id': 'HP_0033141', 'url': 'http://purl.obolibrary.org/obo/HP_0033141', 'lbl': 'Severe SARS-CoV-2 infection', 'desc': 'label: Severe SARS-CoV-2 infection\ndefinition : Unusually severe clinical course of SARS-CoV-2 infection, manifested clinically by features such as dyspnea and hypoxia with diffuse bilateral ground-glass opacities of the lungs on computed tomographic scan with progressive respiratory insufficiency necessitating oxygen supplementation or mechanical ventilation.\nsynonyms :\n'}


{'id': 'HP_0033142', 'url': 'http://purl.obolibrary.org/obo/HP_0033142', 'lbl': 'Long nasal bridge', 'desc': 'label: Long nasal bridge\ndefinition : Increased superior-inferior length of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose.\nsynonyms :\n'}


{'id': 'HP_0033143', 'url': 'http://purl.obolibrary.org/obo/HP_0033143', 'lbl': 'Jejunitis', 'desc': 'label: Jejunitis\ndefinition : Inflammation of the lining of the middle section of the small intestine.\nsynonyms :\n'}


{'id': 'HP_0033144', 'url': 'http://purl.obolibrary.org/obo/HP_0033144', 'lbl': 'Abnormal circulating ceruloplasmin concentration', 'desc': 'label: Abnormal circulating ceruloplasmin concentration\ndefinition : Any deviation of the concentration of ceruloplasmin in the blood from the normal range.\nsynonyms :\n'}


{'id': 'HP_0033145', 'url': 'http://purl.obolibrary.org/obo/HP_0033145', 'lbl': 'Increased circulating ceruloplasmin concentration', 'desc': 'label: Increased circulating ceruloplasmin concentration\ndefinition : Elevated concentration of ceruloplasmin in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033146', 'url': 'http://purl.obolibrary.org/obo/HP_0033146', 'lbl': 'Elevated circulating methylsuccinic acid concentration', 'desc': 'label: Elevated circulating methylsuccinic acid concentration\ndefinition : Increased concentration of methylsuccinic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033147', 'url': 'http://purl.obolibrary.org/obo/HP_0033147', 'lbl': 'Abnormal circulating short-chain fatty-acid concentration', 'desc': 'label: Abnormal circulating short-chain fatty-acid concentration\ndefinition : Any deviation from the normal concentration of a short-chain fatty acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033148', 'url': 'http://purl.obolibrary.org/obo/HP_0033148', 'lbl': 'Increased circulating isovaleric acid concentration', 'desc': 'label: Increased circulating isovaleric acid concentration\ndefinition : Increased concentration of isovaleric acid, a C5, branched-chain saturated fatty acid, in the blood concentration.\nsynonyms :Increased circulating isovalerate; Isovalericacidemia\n'}


{'id': 'HP_0033149', 'url': 'http://purl.obolibrary.org/obo/HP_0033149', 'lbl': 'Intrahepatic bile duct dilatation', 'desc': 'label: Intrahepatic bile duct dilatation\ndefinition : Increased diameter (caliber) of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts).\nsynonyms :Dilatation of intrahepatic biliary ducts\n'}


{'id': 'HP_0033150', 'url': 'http://purl.obolibrary.org/obo/HP_0033150', 'lbl': 'Anorectal abscess', 'desc': 'label: Anorectal abscess\ndefinition : An abscess located at the junction of the anal canal and the rectum.\nsynonyms :\n'}


{'id': 'HP_0033151', 'url': 'http://purl.obolibrary.org/obo/HP_0033151', 'lbl': 'Abnormal pharynx morphology', 'desc': 'label: Abnormal pharynx morphology\ndefinition : A structural anomaly of the pharynx.\nsynonyms :\n'}


{'id': 'HP_0033152', 'url': 'http://purl.obolibrary.org/obo/HP_0033152', 'lbl': 'Abnormal pharynx physiology', 'desc': 'label: Abnormal pharynx physiology\ndefinition : A functional anomaly of the pharynx.\nsynonyms :\n'}


{'id': 'HP_0033153', 'url': 'http://purl.obolibrary.org/obo/HP_0033153', 'lbl': 'Elevated circulating dodecenoylcarnitine concentration', 'desc': 'label: Elevated circulating dodecenoylcarnitine concentration\ndefinition : An abnormally increased circulation of dodecenoylcarnitine, C12:1, in the blood circulation.\nsynonyms :Elevated plasma dodecenoylcarnitine concentration\n'}


{'id': 'HP_0033154', 'url': 'http://purl.obolibrary.org/obo/HP_0033154', 'lbl': 'Elevated circulating deoxypyridinoline concentration', 'desc': 'label: Elevated circulating deoxypyridinoline concentration\ndefinition : An increased concentration of lysyl-pyridinoline (deoxypyridinoline) cross-links in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033155', 'url': 'http://purl.obolibrary.org/obo/HP_0033155', 'lbl': 'Elevated circulating L-alloisoleucine concentration', 'desc': 'label: Elevated circulating L-alloisoleucine concentration\ndefinition : Abnormally increased concentration of L-alloisoleucine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033156', 'url': 'http://purl.obolibrary.org/obo/HP_0033156', 'lbl': 'Elevated urine L-alloisoleucine level', 'desc': 'label: Elevated urine L-alloisoleucine level\ndefinition : Abnormally increased level of L-alloisoleucine in the urine.\nsynonyms :\n'}


{'id': 'HP_0033157', 'url': 'http://purl.obolibrary.org/obo/HP_0033157', 'lbl': 'Elevated circulating 3-methylhistidine concentration', 'desc': 'label: Elevated circulating 3-methylhistidine concentration\ndefinition : Abnormal increase of the concentration of 3-methylhistidine in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0033158', 'url': 'http://purl.obolibrary.org/obo/HP_0033158', 'lbl': 'Reduced respiratory ciliary beating frequency', 'desc': 'label: Reduced respiratory ciliary beating frequency\ndefinition : An abnormal reduction in the number of beats per unit time of the respiratory cilia.\nsynonyms :Dminished respiratory ciliary beat frequency\n'}


{'id': 'HP_0033159', 'url': 'http://purl.obolibrary.org/obo/HP_0033159', 'lbl': 'Reduced urinary inosine level', 'desc': 'label: Reduced urinary inosine level\ndefinition : Decreased level of inosine in urine. Inosine is a purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.\nsynonyms :\n'}


{'id': 'HP_0033160', 'url': 'http://purl.obolibrary.org/obo/HP_0033160', 'lbl': 'Decreased urinary guanosine level', 'desc': 'label: Decreased urinary guanosine level\ndefinition : Decreased level of guanosine in urine. Guanosine is a purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.\nsynonyms :\n'}


{'id': 'HP_0033161', 'url': 'http://purl.obolibrary.org/obo/HP_0033161', 'lbl': 'Abnormal urinary purine level', 'desc': 'label: Abnormal urinary purine level\ndefinition : Any deviation from the normal amount of a purine compound in the urine. Purines are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring. Two of the four deoxyribonucleotides (deoxyadenosine and deoxyguanosine) and two of the four ribonucleotides (adenosine, or AMP, and guanosine, or GMP) are purines.\nsynonyms :\n'}


{'id': 'HP_0033162', 'url': 'http://purl.obolibrary.org/obo/HP_0033162', 'lbl': 'Abnormal urinary pyrimidine level', 'desc': 'label: Abnormal urinary pyrimidine level\ndefinition : Any deviation from the normal amount of a pyrimidine compound in the urine. Pyrimidines and pyrimidine derivatives are compounds containing a pyrimidne ring, which is a six-member aromatic heterocycle which consists of two nitrogen atoms (at positions 1 and 3) and four carbon atoms. The nucleotides cytosine, thymine and uracil are pyrimidines.\nsynonyms :\n'}


{'id': 'HP_0033163', 'url': 'http://purl.obolibrary.org/obo/HP_0033163', 'lbl': 'Small intestinal bacterial overgrowth', 'desc': 'label: Small intestinal bacterial overgrowth\ndefinition : An increased number and/or abnormal type of bacteria in the small bowel. Small intestinal bacterial overgrowth has been defined as the presence of greater than one hundred thousand bacteria (i.e. colony-forming units, CFU) per mL of proximal jejunal aspiration. The normal value is ten thousand or few CFU/ml.\nsynonyms :\n'}


{'id': 'HP_0033164', 'url': 'http://purl.obolibrary.org/obo/HP_0033164', 'lbl': 'Focal active colitis', 'desc': 'label: Focal active colitis\ndefinition : Focal active colitis (FAC) is characterized by focal crypt damage caused by neutrophils. FAC is characterized by an inflammatory infiltrate consisting of intraepithelial neutrophils and/or neutrophils invading the lumen of the criptae, with no other microscopic alteration of the colonic mucosa and, in particular, without the presence of signs of chronic inflammation.\nsynonyms :\n'}