{'id': 'HP_0007963', 'url': 'http://purl.obolibrary.org/obo/HP_0007963', 'lbl': 'Pattern dystrophy of the retina', 'desc': 'label: Pattern dystrophy of the retina\ndefinition : A spectrum of fundoscopic appearances characterized by the development of a variety of patterns of deposits predominantly in the macular area. The deposits are typically bilateral, relatively symmetrical, yellow/white and associated with changes at the level of the retinal pigment epithelium. With time, retinal atrophy may occur. A number of pattern dystrophy subtypes have been described including butterfly-shaped dystrophy, reticular dystrophy (net-like pattern) and fundus pulverulentus (granular, mottled pigmentation).\nsynonyms :\n'}


{'id': 'HP_0007964', 'url': 'http://purl.obolibrary.org/obo/HP_0007964', 'lbl': 'Degenerative vitreoretinopathy', 'desc': 'label: Degenerative vitreoretinopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007965', 'url': 'http://purl.obolibrary.org/obo/HP_0007965', 'lbl': 'Undetectable visual evoked potentials', 'desc': 'label: Undetectable visual evoked potentials\ndefinition : \nsynonyms :Absence of visual evoked potentials; Non-detectable VEP; Undetectable VEP\n'}


{'id': 'HP_0007968', 'url': 'http://purl.obolibrary.org/obo/HP_0007968', 'lbl': 'Remnants of the hyaloid vascular system', 'desc': 'label: Remnants of the hyaloid vascular system\ndefinition : Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disk to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth. This features results from a failure of regression of the hyaloid vessel, which supplies the primary vitreous during embryogenesis and normally regresses in the third trimester of pregnancy, leading to a particular form of posterior cataract.\nsynonyms :Congenital retinal septum; Persistent fetal vasculature; Persistent foetal vasculature; Persistent hyperplasia of primary vitreous; Persistent hyperplastic primary vitreous; Persistent hypertrophic primary vitreous; Persistent posterior fetal fibrovascular sheath of the lens; Persistent posterior foetal fibrovascular sheath of the lens; Persistent tunica vasculosa lentis\n'}


{'id': 'HP_0007970', 'url': 'http://purl.obolibrary.org/obo/HP_0007970', 'lbl': 'Congenital ptosis', 'desc': 'label: Congenital ptosis\ndefinition : \nsynonyms :Congenital drooping upper eyelid\n'}


{'id': 'HP_0007971', 'url': 'http://purl.obolibrary.org/obo/HP_0007971', 'lbl': 'Lamellar cataract', 'desc': 'label: Lamellar cataract\ndefinition : A congenital cataract in which opacity is limited to layers of the lens external to the nucleus (i.e., the perinuclear region), i.e., between the nuclear and cortical layers of the lens.\nsynonyms :\n'}


{'id': 'HP_0007973', 'url': 'http://purl.obolibrary.org/obo/HP_0007973', 'lbl': 'Retinal dysplasia', 'desc': 'label: Retinal dysplasia\ndefinition : The presence of developmental dysplasia of the retina.\nsynonyms :Retinal dysgenesis\n'}


{'id': 'HP_0007975', 'url': 'http://purl.obolibrary.org/obo/HP_0007975', 'lbl': 'Hypometric horizontal saccades', 'desc': 'label: Hypometric horizontal saccades\ndefinition : Saccadic undershoot of horizontal saccadic eye movements, i.e., a horizontal saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object.\nsynonyms :\n'}


{'id': 'HP_0007976', 'url': 'http://purl.obolibrary.org/obo/HP_0007976', 'lbl': 'Cerulean cataract', 'desc': 'label: Cerulean cataract\ndefinition : Cerulean cataracts are a kind of congenital cataract having peripheral bluish and white opacifications in concentric layers with occasional central lesions arranged radially. Although the opacities may be observed during fetal development and childhood, usually visual acuity is only mildly reduced until adulthood, when lens extraction is generally necessary.\nsynonyms :Cataracts, congenital, cerulean\n'}


{'id': 'HP_0007979', 'url': 'http://purl.obolibrary.org/obo/HP_0007979', 'lbl': 'Gaze-evoked horizontal nystagmus', 'desc': 'label: Gaze-evoked horizontal nystagmus\ndefinition : Horizontal nystagmus made apparent by looking to the right or to the left.\nsynonyms :Nystagmus, horizontal, gaze-evoked; Nystagmus, horizontal gaze-evoked\n'}


{'id': 'HP_0007980', 'url': 'http://purl.obolibrary.org/obo/HP_0007980', 'lbl': 'Absent retinal pigment epithelium', 'desc': 'label: Absent retinal pigment epithelium\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007981', 'url': 'http://purl.obolibrary.org/obo/HP_0007981', 'lbl': 'obsolete Concentric narrowing of visual field', 'desc': 'label: obsolete Concentric narrowing of visual field\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007982', 'url': 'http://purl.obolibrary.org/obo/HP_0007982', 'lbl': 'obsolete Central tapetoretinal dystrophy', 'desc': 'label: obsolete Central tapetoretinal dystrophy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007984', 'url': 'http://purl.obolibrary.org/obo/HP_0007984', 'lbl': 'Electronegative electroretinogram', 'desc': 'label: Electronegative electroretinogram\ndefinition : A dark-adapted bright flash electroretinogram in which the b-wave that is of markedly lower amplitude than the associated a-wave (source: Holder GE., Inherited Chorioretinal Dystrophies: A Textbook and Atlas; 2014; p.17; ISBN 978-3-540-69466-3).\nsynonyms :Electronegative ERG; Electroretinogram: reduced b-wave amplitude; Reduced ERG amplitude of b-wave; Reduced amplitude of dark-adapted bright flash electroretinogram b-wave; Reduced electroretinogram rod b-wave\n'}


{'id': 'HP_0007985', 'url': 'http://purl.obolibrary.org/obo/HP_0007985', 'lbl': 'Retinal arteriolar occlusion', 'desc': 'label: Retinal arteriolar occlusion\ndefinition : Blockage of retinal arteriole, generally associated with interruption of blood flow and oxygen delivery to affected regions of the retina.\nsynonyms :Blocked retinal artery\n'}


{'id': 'HP_0007986', 'url': 'http://purl.obolibrary.org/obo/HP_0007986', 'lbl': 'Increased retinal vascularity', 'desc': 'label: Increased retinal vascularity\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007987', 'url': 'http://purl.obolibrary.org/obo/HP_0007987', 'lbl': 'Progressive visual field defects', 'desc': 'label: Progressive visual field defects\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007988', 'url': 'http://purl.obolibrary.org/obo/HP_0007988', 'lbl': 'Macular hypopigmentation', 'desc': 'label: Macular hypopigmentation\ndefinition : Decreased amount of pigmentation in the macula lutea.\nsynonyms :\n'}


{'id': 'HP_0007989', 'url': 'http://purl.obolibrary.org/obo/HP_0007989', 'lbl': 'Intraretinal exudate', 'desc': 'label: Intraretinal exudate\ndefinition : Retinal exudate within the retinal tissue itself.\nsynonyms :\n'}


{'id': 'HP_0007990', 'url': 'http://purl.obolibrary.org/obo/HP_0007990', 'lbl': 'Hypoplastic iris stroma', 'desc': 'label: Hypoplastic iris stroma\ndefinition : Underdevelopment of the stroma of iris.\nsynonyms :Hypoplastic iris stoma; Iris stromal hypoplasia; Underdeveloped iris stroma\n'}


{'id': 'HP_0007992', 'url': 'http://purl.obolibrary.org/obo/HP_0007992', 'lbl': 'Lattice retinal degeneration', 'desc': 'label: Lattice retinal degeneration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0007993', 'url': 'http://purl.obolibrary.org/obo/HP_0007993', 'lbl': 'Malformed lacrimal duct', 'desc': 'label: Malformed lacrimal duct\ndefinition : Congenital malformation of the lacrimal duct associated with incomplete development of the bony nasolacrimal canal or craniofacial anomalies.\nsynonyms :Malformed tear ducts\n'}


{'id': 'HP_0007994', 'url': 'http://purl.obolibrary.org/obo/HP_0007994', 'lbl': 'Peripheral visual field loss', 'desc': 'label: Peripheral visual field loss\ndefinition : Loss of peripheral vision with retention of central vision, resulting in a constricted circular tunnel-like field of vision.\nsynonyms :Kalnienk vision; Loss of peripheral vision; Tunnel vision\n'}


{'id': 'HP_0008000', 'url': 'http://purl.obolibrary.org/obo/HP_0008000', 'lbl': 'Decreased corneal reflex', 'desc': 'label: Decreased corneal reflex\ndefinition : An abnormally reduced response to stimulation of the cornea (by touch, foreign body, blowing air). The corneal reflex (also known as the blink reflex, normally results in an involuntary blinking of the eyelids.\nsynonyms :Decreased blink reflex; Reduced corneal reflex\n'}


{'id': 'HP_0008001', 'url': 'http://purl.obolibrary.org/obo/HP_0008001', 'lbl': 'Foveal hyperpigmentation', 'desc': 'label: Foveal hyperpigmentation\ndefinition : Increased amount of pigmentation in the fovea centralis.\nsynonyms :\n'}


{'id': 'HP_0008002', 'url': 'http://purl.obolibrary.org/obo/HP_0008002', 'lbl': 'Abnormality of macular pigmentation', 'desc': 'label: Abnormality of macular pigmentation\ndefinition : Abnormality of macular or foveal pigmentation.\nsynonyms :Macular pigmentary changes\n'}


{'id': 'HP_0008003', 'url': 'http://purl.obolibrary.org/obo/HP_0008003', 'lbl': 'Jerky ocular pursuit movements', 'desc': 'label: Jerky ocular pursuit movements\ndefinition : \nsynonyms :Jerky smooth pursuit\n'}


{'id': 'HP_0008005', 'url': 'http://purl.obolibrary.org/obo/HP_0008005', 'lbl': 'obsolete Congenital corneal dystrophy', 'desc': 'label: obsolete Congenital corneal dystrophy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008007', 'url': 'http://purl.obolibrary.org/obo/HP_0008007', 'lbl': 'Primary congenital glaucoma', 'desc': 'label: Primary congenital glaucoma\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008008', 'url': 'http://purl.obolibrary.org/obo/HP_0008008', 'lbl': 'obsolete Progressive central visual loss', 'desc': 'label: obsolete Progressive central visual loss\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008009', 'url': 'http://purl.obolibrary.org/obo/HP_0008009', 'lbl': 'Three rows of eyelashes', 'desc': 'label: Three rows of eyelashes\ndefinition : \nsynonyms :Three rows of eyelashes; Triple row of eyelashes\n'}


{'id': 'HP_0008011', 'url': 'http://purl.obolibrary.org/obo/HP_0008011', 'lbl': 'Peripheral opacification of the cornea', 'desc': 'label: Peripheral opacification of the cornea\ndefinition : Reduced transparency of the peripheral region of the cornea.\nsynonyms :Peripheral corneal opacity\n'}


{'id': 'HP_0008012', 'url': 'http://purl.obolibrary.org/obo/HP_0008012', 'lbl': 'obsolete Congenital myopia', 'desc': 'label: obsolete Congenital myopia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008014', 'url': 'http://purl.obolibrary.org/obo/HP_0008014', 'lbl': 'Central fundal arteriolar microaneurysms', 'desc': 'label: Central fundal arteriolar microaneurysms\ndefinition : Microscopic aneurysms of the retinal arterioles near the central part of the fundus, visible as small round dark red dots on the retinal surface (not arising from visible vessels) that are by definition less than the diameter of the major optic veins as they cross the optic disc.\nsynonyms :\n'}


{'id': 'HP_0008017', 'url': 'http://purl.obolibrary.org/obo/HP_0008017', 'lbl': 'obsolete Depigmented lesions of the retinal pigment epithelium', 'desc': 'label: obsolete Depigmented lesions of the retinal pigment epithelium\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008019', 'url': 'http://purl.obolibrary.org/obo/HP_0008019', 'lbl': 'Superior lens subluxation', 'desc': 'label: Superior lens subluxation\ndefinition : Partial dislocation of the lens in a superior direction.\nsynonyms :Superior subluxated lens\n'}


{'id': 'HP_0008020', 'url': 'http://purl.obolibrary.org/obo/HP_0008020', 'lbl': 'Cone dystrophy', 'desc': 'label: Cone dystrophy\ndefinition : Inherited progressive cone degeneration.\nsynonyms :Progressive cone degeneration; Progressive cone dystrophy\n'}


{'id': 'HP_0008024', 'url': 'http://purl.obolibrary.org/obo/HP_0008024', 'lbl': 'obsolete Congenital nuclear cataract', 'desc': 'label: obsolete Congenital nuclear cataract\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008026', 'url': 'http://purl.obolibrary.org/obo/HP_0008026', 'lbl': 'Horizontal opticokinetic nystagmus', 'desc': 'label: Horizontal opticokinetic nystagmus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008028', 'url': 'http://purl.obolibrary.org/obo/HP_0008028', 'lbl': 'Cystoid macular degeneration', 'desc': 'label: Cystoid macular degeneration\ndefinition : A form of macular degeneration characterized by the presence of multiple cysts in the macula.\nsynonyms :Cystic macular degeneration\n'}


{'id': 'HP_0008030', 'url': 'http://purl.obolibrary.org/obo/HP_0008030', 'lbl': 'Retinal arteritis', 'desc': 'label: Retinal arteritis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008031', 'url': 'http://purl.obolibrary.org/obo/HP_0008031', 'lbl': 'Posterior Y-sutural cataract', 'desc': 'label: Posterior Y-sutural cataract\ndefinition : A type of sutural cataract in which the opacity follows the posterior Y suture.\nsynonyms :Posterior Y-sutural cataracts\n'}


{'id': 'HP_0008033', 'url': 'http://purl.obolibrary.org/obo/HP_0008033', 'lbl': 'obsolete Congenital exotropia', 'desc': 'label: obsolete Congenital exotropia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008034', 'url': 'http://purl.obolibrary.org/obo/HP_0008034', 'lbl': 'Abnormal iris pigmentation', 'desc': 'label: Abnormal iris pigmentation\ndefinition : Abnormal pigmentation of the iris.\nsynonyms :\n'}


{'id': 'HP_0008035', 'url': 'http://purl.obolibrary.org/obo/HP_0008035', 'lbl': 'Retinitis pigmentosa inversa', 'desc': 'label: Retinitis pigmentosa inversa\ndefinition : Retinitis pigmentosa inversa is form of retinal degeneration characterized by areas of retinal/chorioretinal degeneration with pigment migration in the macular area (in contrast to retinitis pigmentosa which, at early disease stages, predominantly affects the retinal periphery).\nsynonyms :Central retinitis pigmentosa\n'}


{'id': 'HP_0008036', 'url': 'http://purl.obolibrary.org/obo/HP_0008036', 'lbl': 'obsolete Rod-cone dystrophy', 'desc': 'label: obsolete Rod-cone dystrophy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008037', 'url': 'http://purl.obolibrary.org/obo/HP_0008037', 'lbl': 'Absent anterior chamber of the eye', 'desc': 'label: Absent anterior chamber of the eye\ndefinition : Absence of the anterior chamber of the eye owing to a developmental defect.\nsynonyms :\n'}


{'id': 'HP_0008038', 'url': 'http://purl.obolibrary.org/obo/HP_0008038', 'lbl': 'Aplastic/hypoplastic lacrimal glands', 'desc': 'label: Aplastic/hypoplastic lacrimal glands\ndefinition : Absence or underdevelopment of the lacrimal gland.\nsynonyms :Absent/underdeveloped lacrimal glands; Absent/underdeveloped tear glands\n'}


{'id': 'HP_0008039', 'url': 'http://purl.obolibrary.org/obo/HP_0008039', 'lbl': 'Subepithelial corneal opacities', 'desc': 'label: Subepithelial corneal opacities\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008041', 'url': 'http://purl.obolibrary.org/obo/HP_0008041', 'lbl': 'Late onset congenital glaucoma', 'desc': 'label: Late onset congenital glaucoma\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008043', 'url': 'http://purl.obolibrary.org/obo/HP_0008043', 'lbl': 'Retinal arteriolar constriction', 'desc': 'label: Retinal arteriolar constriction\ndefinition : Decreased retinal arteriolar diameters, which may decrease blood flow and slow oxygen delivery to regions of the retina.\nsynonyms :Constricted retinal arterioles; Narrow retinal arterioles; Retinal arteriolar narrowing\n'}


{'id': 'HP_0008045', 'url': 'http://purl.obolibrary.org/obo/HP_0008045', 'lbl': 'Enlarged flash visual evoked potentials', 'desc': 'label: Enlarged flash visual evoked potentials\ndefinition : \nsynonyms :High flash visual evoked potentials\n'}


{'id': 'HP_0008046', 'url': 'http://purl.obolibrary.org/obo/HP_0008046', 'lbl': 'Abnormal retinal vascular morphology', 'desc': 'label: Abnormal retinal vascular morphology\ndefinition : A structural abnormality of retinal vasculature.\nsynonyms :Abnormality of retina blood vessels; Abnormality of the retinal vasculature\n'}


{'id': 'HP_0008047', 'url': 'http://purl.obolibrary.org/obo/HP_0008047', 'lbl': 'Abnormality of the vasculature of the eye', 'desc': 'label: Abnormality of the vasculature of the eye\ndefinition : \nsynonyms :Abnormality of eye blood vessels\n'}


{'id': 'HP_0008048', 'url': 'http://purl.obolibrary.org/obo/HP_0008048', 'lbl': 'Abnormal line of Schwalbe morphology', 'desc': 'label: Abnormal line of Schwalbe morphology\ndefinition : An abnormality of the line of Schwalbe.\nsynonyms :Abnormality of the line of Schwalbe\n'}


{'id': 'HP_0008049', 'url': 'http://purl.obolibrary.org/obo/HP_0008049', 'lbl': 'Abnormality of the extraocular muscles', 'desc': 'label: Abnormality of the extraocular muscles\ndefinition : An abnormality of an extraocular muscle.\nsynonyms :\n'}


{'id': 'HP_0008050', 'url': 'http://purl.obolibrary.org/obo/HP_0008050', 'lbl': 'Abnormality of the palpebral fissures', 'desc': 'label: Abnormality of the palpebral fissures\ndefinition : An anomaly of the space between the medial and lateral canthi of the two open eyelids.\nsynonyms :Abnormality of the opening between the eyelids; Abnormality of the palpebral fissures; Deformity of the palpebral fissures; Malformation of the palpebral fissures\n'}


{'id': 'HP_0008051', 'url': 'http://purl.obolibrary.org/obo/HP_0008051', 'lbl': 'obsolete Abnormality of the retinal pigment epithelium', 'desc': 'label: obsolete Abnormality of the retinal pigment epithelium\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008052', 'url': 'http://purl.obolibrary.org/obo/HP_0008052', 'lbl': 'Retinal fold', 'desc': 'label: Retinal fold\ndefinition : A wrinkle of retinal tissue projecting outward from the surface of the retina and visible as a line on fundoscopy.\nsynonyms :Retinal folds\n'}


{'id': 'HP_0008053', 'url': 'http://purl.obolibrary.org/obo/HP_0008053', 'lbl': 'Aplasia/Hypoplasia of the iris', 'desc': 'label: Aplasia/Hypoplasia of the iris\ndefinition : Absence or underdevelopment of the iris.\nsynonyms :Absent/small iris; Absent/underdeveloped iris\n'}


{'id': 'HP_0008054', 'url': 'http://purl.obolibrary.org/obo/HP_0008054', 'lbl': 'Abnormal morphology of the conjunctival vasculature', 'desc': 'label: Abnormal morphology of the conjunctival vasculature\ndefinition : Any abnormality of the blood vessels of the conjunctiva.\nsynonyms :Abnormal morphology of the conjunctiva vasculature; Abnormal vasculature of the conjunctiva morphology; Abnormality of the vasculature of the conjunctiva\n'}


{'id': 'HP_0008055', 'url': 'http://purl.obolibrary.org/obo/HP_0008055', 'lbl': 'Aplasia/Hypoplasia affecting the uvea', 'desc': 'label: Aplasia/Hypoplasia affecting the uvea\ndefinition : Absence or underdevelopment of the uvea, the pigmented middle layer of the eye consisting of the iris and ciliary body together with the choroid.\nsynonyms :Absent/underdeveloped uvea\n'}


{'id': 'HP_0008056', 'url': 'http://purl.obolibrary.org/obo/HP_0008056', 'lbl': 'Aplasia/Hypoplasia affecting the eye', 'desc': 'label: Aplasia/Hypoplasia affecting the eye\ndefinition : \nsynonyms :Absent/small eye; Absent/underdeveloped eye\n'}


{'id': 'HP_0008057', 'url': 'http://purl.obolibrary.org/obo/HP_0008057', 'lbl': 'Aplasia/Hypoplasia affecting the fundus', 'desc': 'label: Aplasia/Hypoplasia affecting the fundus\ndefinition : \nsynonyms :Absent/small fundus\n'}


{'id': 'HP_0008058', 'url': 'http://purl.obolibrary.org/obo/HP_0008058', 'lbl': 'Aplasia/Hypoplasia of the optic nerve', 'desc': 'label: Aplasia/Hypoplasia of the optic nerve\ndefinition : \nsynonyms :Absent/small optic nerve; Absent/underdeveloped optic nerve\n'}


{'id': 'HP_0008059', 'url': 'http://purl.obolibrary.org/obo/HP_0008059', 'lbl': 'Aplasia/Hypoplasia of the macula', 'desc': 'label: Aplasia/Hypoplasia of the macula\ndefinition : \nsynonyms :Absent/underdeveloped macula\n'}


{'id': 'HP_0008060', 'url': 'http://purl.obolibrary.org/obo/HP_0008060', 'lbl': 'Aplasia/Hypoplasia of the fovea', 'desc': 'label: Aplasia/Hypoplasia of the fovea\ndefinition : Congenital absence or underdevelopment of the fovea centralis.\nsynonyms :Absent/underdeveloped fovea\n'}


{'id': 'HP_0008061', 'url': 'http://purl.obolibrary.org/obo/HP_0008061', 'lbl': 'Aplasia/Hypoplasia of the retina', 'desc': 'label: Aplasia/Hypoplasia of the retina\ndefinition : \nsynonyms :Absent/small retina; Absent/underdeveloped retina\n'}


{'id': 'HP_0008062', 'url': 'http://purl.obolibrary.org/obo/HP_0008062', 'lbl': 'Aplasia/Hypoplasia affecting the anterior segment of the eye', 'desc': 'label: Aplasia/Hypoplasia affecting the anterior segment of the eye\ndefinition : Absence or underdevelopment of the anterior segment of the eye.\nsynonyms :\n'}


{'id': 'HP_0008063', 'url': 'http://purl.obolibrary.org/obo/HP_0008063', 'lbl': 'Aplasia/Hypoplasia of the lens', 'desc': 'label: Aplasia/Hypoplasia of the lens\ndefinition : Absence or underdevelopment of the lens.\nsynonyms :Absent/small lens; Absent/underdeveloped lens\n'}


{'id': 'HP_0008064', 'url': 'http://purl.obolibrary.org/obo/HP_0008064', 'lbl': 'Ichthyosis', 'desc': 'label: Ichthyosis\ndefinition : An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization.\nsynonyms :Ichthyosiform abnormality of the skin; Ichthyotic skin; Hypertrophic ichthyosis\n'}


{'id': 'HP_0008065', 'url': 'http://purl.obolibrary.org/obo/HP_0008065', 'lbl': 'Aplasia/Hypoplasia of the skin', 'desc': 'label: Aplasia/Hypoplasia of the skin\ndefinition : \nsynonyms :Absent/small skin; Absent/underdeveloped skin\n'}


{'id': 'HP_0008066', 'url': 'http://purl.obolibrary.org/obo/HP_0008066', 'lbl': 'Abnormal blistering of the skin', 'desc': 'label: Abnormal blistering of the skin\ndefinition : The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls.\nsynonyms :Abnormal blistering of the skin; Blister; Blistering, generalised; Blistering, generalized; Blisters; Skin bullae; Skin blisters\n'}


{'id': 'HP_0008067', 'url': 'http://purl.obolibrary.org/obo/HP_0008067', 'lbl': 'Abnormally lax or hyperextensible skin', 'desc': 'label: Abnormally lax or hyperextensible skin\ndefinition : \nsynonyms :Abnormally loose or hyperelastic skin; Abnormally loose or stretchable skin\n'}


{'id': 'HP_0008069', 'url': 'http://purl.obolibrary.org/obo/HP_0008069', 'lbl': 'Neoplasm of the skin', 'desc': 'label: Neoplasm of the skin\ndefinition : A tumor (abnormal growth of tissue) of the skin.\nsynonyms :Skin cancer (non-melanoma); Dermatological tumors; Dermatological tumours; Skin tumors; Skin tumours; Tumor of the skin; Tumour of the skin; Neoplasia of the skin; Skin cancer\n'}


{'id': 'HP_0008070', 'url': 'http://purl.obolibrary.org/obo/HP_0008070', 'lbl': 'Sparse hair', 'desc': 'label: Sparse hair\ndefinition : Reduced density of hairs.\nsynonyms :Decreased hair growth; Decreased hair growth on body; Hypotrichosis; Marked hypotrichosis; Sparse hair; Sparse hair since birth; Thin, sparse hair\n'}


{'id': 'HP_0008071', 'url': 'http://purl.obolibrary.org/obo/HP_0008071', 'lbl': 'Maternal hypertension', 'desc': 'label: Maternal hypertension\ndefinition : Increased blood pressure during a pregnancy.\nsynonyms :\n'}


{'id': 'HP_0008072', 'url': 'http://purl.obolibrary.org/obo/HP_0008072', 'lbl': 'Maternal virilization in pregnancy', 'desc': 'label: Maternal virilization in pregnancy\ndefinition : Virilization (deepening of voice, facial hirsutism and scalp hair loss) with onset during pregnancy (usually towards the end of the first trimester) and regression several months post-partum.\nsynonyms :\n'}


{'id': 'HP_0008073', 'url': 'http://purl.obolibrary.org/obo/HP_0008073', 'lbl': 'Low maternal circulating estriol concentration', 'desc': 'label: Low maternal circulating estriol concentration\ndefinition : An abnormally low concentration of serum conjugated estriol as compared to normal values for gestational-age.\nsynonyms :Low maternal serum estriol\n'}


{'id': 'HP_0008074', 'url': 'http://purl.obolibrary.org/obo/HP_0008074', 'lbl': 'Metatarsal periosteal thickening', 'desc': 'label: Metatarsal periosteal thickening\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008075', 'url': 'http://purl.obolibrary.org/obo/HP_0008075', 'lbl': 'obsolete Progressive pes cavus', 'desc': 'label: obsolete Progressive pes cavus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008076', 'url': 'http://purl.obolibrary.org/obo/HP_0008076', 'lbl': 'Osteoporotic tarsals', 'desc': 'label: Osteoporotic tarsals\ndefinition : Reduction in bone mineral density affecting any or all of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.\nsynonyms :\n'}


{'id': 'HP_0008078', 'url': 'http://purl.obolibrary.org/obo/HP_0008078', 'lbl': 'Thin metatarsal cortices', 'desc': 'label: Thin metatarsal cortices\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008079', 'url': 'http://purl.obolibrary.org/obo/HP_0008079', 'lbl': 'Absent fifth metatarsal', 'desc': 'label: Absent fifth metatarsal\ndefinition : A developmental abnormality characterized by the absence of the fifth metatarsal bone.\nsynonyms :Absent 5th long bone of foot; Absent 5th metatarsals; Aplasia of the fifth metatarsal bone\n'}


{'id': 'HP_0008080', 'url': 'http://purl.obolibrary.org/obo/HP_0008080', 'lbl': 'Hallux varus', 'desc': 'label: Hallux varus\ndefinition : Medial deviation of the great toe owing to a deformity of the great toe joint causing the hallux to deviate medially.\nsynonyms :Medially deviated halluces\n'}


{'id': 'HP_0008081', 'url': 'http://purl.obolibrary.org/obo/HP_0008081', 'lbl': 'Pes valgus', 'desc': 'label: Pes valgus\ndefinition : An outward deviation of the foot at the talocalcaneal or subtalar joint.\nsynonyms :Valgus foot deformity\n'}


{'id': 'HP_0008082', 'url': 'http://purl.obolibrary.org/obo/HP_0008082', 'lbl': 'Medial deviation of the foot', 'desc': 'label: Medial deviation of the foot\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008083', 'url': 'http://purl.obolibrary.org/obo/HP_0008083', 'lbl': '2nd-5th toe middle phalangeal hypoplasia', 'desc': 'label: 2nd-5th toe middle phalangeal hypoplasia\ndefinition : \nsynonyms :Underdeveloped 2nd-5th middle toe bones\n'}


{'id': 'HP_0008087', 'url': 'http://purl.obolibrary.org/obo/HP_0008087', 'lbl': 'Nonossified fifth metatarsal', 'desc': 'label: Nonossified fifth metatarsal\ndefinition : The presence of a fifth metatarsal bone that has not undergone ossification at an age when ossification is usually visible.\nsynonyms :\n'}


{'id': 'HP_0008089', 'url': 'http://purl.obolibrary.org/obo/HP_0008089', 'lbl': 'Abnormality of the fifth metatarsal bone', 'desc': 'label: Abnormality of the fifth metatarsal bone\ndefinition : An anomaly of the fifth metatarsal bone.\nsynonyms :Abnormality of the 5th long bone of foot\n'}


{'id': 'HP_0008090', 'url': 'http://purl.obolibrary.org/obo/HP_0008090', 'lbl': 'Ankylosis of feet small joints', 'desc': 'label: Ankylosis of feet small joints\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008093', 'url': 'http://purl.obolibrary.org/obo/HP_0008093', 'lbl': 'Short 4th toe', 'desc': 'label: Short 4th toe\ndefinition : Underdevelopment (hypoplasia) of the fourth toe.\nsynonyms :Short 4th toe; Short fourth toe\n'}


{'id': 'HP_0008094', 'url': 'http://purl.obolibrary.org/obo/HP_0008094', 'lbl': 'Widely spaced toes', 'desc': 'label: Widely spaced toes\ndefinition : An overall widening of the spaces between the digits.\nsynonyms :Widely spaced toes\n'}


{'id': 'HP_0008095', 'url': 'http://purl.obolibrary.org/obo/HP_0008095', 'lbl': 'Osteolysis of talus', 'desc': 'label: Osteolysis of talus\ndefinition : Osteolysis affecting the talus.\nsynonyms :Osteolysis of tali\n'}


{'id': 'HP_0008096', 'url': 'http://purl.obolibrary.org/obo/HP_0008096', 'lbl': 'Medially deviated second toe', 'desc': 'label: Medially deviated second toe\ndefinition : Medial deviation of the second toe.\nsynonyms :\n'}


{'id': 'HP_0008097', 'url': 'http://purl.obolibrary.org/obo/HP_0008097', 'lbl': 'Partial fusion of tarsals', 'desc': 'label: Partial fusion of tarsals\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008102', 'url': 'http://purl.obolibrary.org/obo/HP_0008102', 'lbl': 'Expanded metatarsals with widened medullary cavities', 'desc': 'label: Expanded metatarsals with widened medullary cavities\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008103', 'url': 'http://purl.obolibrary.org/obo/HP_0008103', 'lbl': 'Delayed tarsal ossification', 'desc': 'label: Delayed tarsal ossification\ndefinition : Delayed maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.\nsynonyms :Tarsal delayed ossification; Delayed ankle bone maturation\n'}


{'id': 'HP_0008107', 'url': 'http://purl.obolibrary.org/obo/HP_0008107', 'lbl': 'Plantar crease between first and second toes', 'desc': 'label: Plantar crease between first and second toes\ndefinition : The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot located between the first and second toe.\nsynonyms :\n'}


{'id': 'HP_0008108', 'url': 'http://purl.obolibrary.org/obo/HP_0008108', 'lbl': 'Advanced tarsal ossification', 'desc': 'label: Advanced tarsal ossification\ndefinition : Precocious (accelerated) maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.\nsynonyms :Precociously ossified tarsal bones; Accelerated ankle bone maturation\n'}


{'id': 'HP_0008110', 'url': 'http://purl.obolibrary.org/obo/HP_0008110', 'lbl': 'Equinovarus deformity', 'desc': 'label: Equinovarus deformity\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008111', 'url': 'http://purl.obolibrary.org/obo/HP_0008111', 'lbl': 'Broad distal hallux', 'desc': 'label: Broad distal hallux\ndefinition : \nsynonyms :Broad distal big toe\n'}


{'id': 'HP_0008112', 'url': 'http://purl.obolibrary.org/obo/HP_0008112', 'lbl': 'Plantar flexion contracture', 'desc': 'label: Plantar flexion contracture\ndefinition : A type of contracture in which the plantar flexion muscles are contracted.\nsynonyms :Plantar flexion contractures\n'}


{'id': 'HP_0008113', 'url': 'http://purl.obolibrary.org/obo/HP_0008113', 'lbl': 'Multiple plantar creases', 'desc': 'label: Multiple plantar creases\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008114', 'url': 'http://purl.obolibrary.org/obo/HP_0008114', 'lbl': 'Metatarsal diaphyseal endosteal sclerosis', 'desc': 'label: Metatarsal diaphyseal endosteal sclerosis\ndefinition : Osteosclerosis of the endosteal surface of the diaphyses (shafts) of the metatarsal bones.\nsynonyms :\n'}


{'id': 'HP_0008115', 'url': 'http://purl.obolibrary.org/obo/HP_0008115', 'lbl': 'Clinodactyly of the 3rd toe', 'desc': 'label: Clinodactyly of the 3rd toe\ndefinition : Bending or curvature of a third toe in the tibial direction (i.e., towards the big toe).\nsynonyms :Curvature of 3rd toe; 3rd toe clinodactyly\n'}


{'id': 'HP_0008116', 'url': 'http://purl.obolibrary.org/obo/HP_0008116', 'lbl': 'Flexion limitation of toes', 'desc': 'label: Flexion limitation of toes\ndefinition : Limitation of the ability to bend the toes.\nsynonyms :\n'}


{'id': 'HP_0008117', 'url': 'http://purl.obolibrary.org/obo/HP_0008117', 'lbl': 'Shortening of the talar neck', 'desc': 'label: Shortening of the talar neck\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008119', 'url': 'http://purl.obolibrary.org/obo/HP_0008119', 'lbl': 'Deformed tarsal bones', 'desc': 'label: Deformed tarsal bones\ndefinition : \nsynonyms :Deformed ankle bones\n'}


{'id': 'HP_0008122', 'url': 'http://purl.obolibrary.org/obo/HP_0008122', 'lbl': 'Calcaneonavicular fusion', 'desc': 'label: Calcaneonavicular fusion\ndefinition : Synostosis of the calcaneus with the navicular bone.\nsynonyms :\n'}


{'id': 'HP_0008124', 'url': 'http://purl.obolibrary.org/obo/HP_0008124', 'lbl': 'Talipes calcaneovarus', 'desc': 'label: Talipes calcaneovarus\ndefinition : A congenital deformity characterized by a dorsiflexed, inverted, and adducted foot, i.e., a combination of talipes calcaneus and talipes varus.\nsynonyms :\n'}


{'id': 'HP_0008125', 'url': 'http://purl.obolibrary.org/obo/HP_0008125', 'lbl': 'Second metatarsal posteriorly placed', 'desc': 'label: Second metatarsal posteriorly placed\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008127', 'url': 'http://purl.obolibrary.org/obo/HP_0008127', 'lbl': 'Bipartite calcaneus', 'desc': 'label: Bipartite calcaneus\ndefinition : A two-part calcaneus, a finding that probably results from delayed coalescence of two primary calcaneal centers of ossification.\nsynonyms :Delayed coalescence of bipartite calcanei; Delayed coalescence of calcaneal ossification centers; Delayed coalescence of calcaneal ossification centres; Delayed fusion of bipartite calcanei; Double calcaneal ossification center; Double calcaneal ossification centre; Extra calcaneal ossification center; Extra calcaneal ossification centre\n'}


{'id': 'HP_0008131', 'url': 'http://purl.obolibrary.org/obo/HP_0008131', 'lbl': 'Tarsal stippling', 'desc': 'label: Tarsal stippling\ndefinition : The presence of abnormal punctate (speckled, dot-like) calcifications in one or more tarsal bones.\nsynonyms :Punctate calcifications of tarsals; Punctate tarsal calcification\n'}


{'id': 'HP_0008132', 'url': 'http://purl.obolibrary.org/obo/HP_0008132', 'lbl': 'Medial rotation of the medial malleolus', 'desc': 'label: Medial rotation of the medial malleolus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008133', 'url': 'http://purl.obolibrary.org/obo/HP_0008133', 'lbl': 'Distal tapering of metatarsals', 'desc': 'label: Distal tapering of metatarsals\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008134', 'url': 'http://purl.obolibrary.org/obo/HP_0008134', 'lbl': 'Irregular tarsal ossification', 'desc': 'label: Irregular tarsal ossification\ndefinition : Defective ossification in an irregular pattern of the seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.\nsynonyms :Irregular tarsal centers; Irregular tarsal centres; Irregular ankle bone maturation\n'}


{'id': 'HP_0008138', 'url': 'http://purl.obolibrary.org/obo/HP_0008138', 'lbl': 'Equinus calcaneus', 'desc': 'label: Equinus calcaneus\ndefinition : Abnormal plantar flexion of the calcaneus relative to the longitudinal axis of the tibia. This results in the angle between the long axis of the tibia and the long axis of the heel bone (calcaneus) being greater than 90 degrees.\nsynonyms :Equinus deformity of the calcaneus; Hindfoot equinus\n'}


{'id': 'HP_0008141', 'url': 'http://purl.obolibrary.org/obo/HP_0008141', 'lbl': 'Dislocation of toes', 'desc': 'label: Dislocation of toes\ndefinition : \nsynonyms :Dislocation of toes\n'}


{'id': 'HP_0008142', 'url': 'http://purl.obolibrary.org/obo/HP_0008142', 'lbl': 'Delayed calcaneal ossification', 'desc': 'label: Delayed calcaneal ossification\ndefinition : Delayed maturation and calcification of the calcaneus.\nsynonyms :Delayed heel bone maturation\n'}


{'id': 'HP_0008144', 'url': 'http://purl.obolibrary.org/obo/HP_0008144', 'lbl': 'Flattening of the talar dome', 'desc': 'label: Flattening of the talar dome\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008148', 'url': 'http://purl.obolibrary.org/obo/HP_0008148', 'lbl': 'Impaired epinephrine-induced platelet aggregation', 'desc': 'label: Impaired epinephrine-induced platelet aggregation\ndefinition : Abnormal response to epinephrine as manifested by reduced or lacking aggregation of platelets upon addition of epinephrine.\nsynonyms :\n'}


{'id': 'HP_0008150', 'url': 'http://purl.obolibrary.org/obo/HP_0008150', 'lbl': 'Elevated serum transaminases during infections', 'desc': 'label: Elevated serum transaminases during infections\ndefinition : Elevations of the levels of SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) that occur during infections.\nsynonyms :\n'}


{'id': 'HP_0008151', 'url': 'http://purl.obolibrary.org/obo/HP_0008151', 'lbl': 'Prolonged prothrombin time', 'desc': "label: Prolonged prothrombin time\ndefinition : Increased time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT.\nsynonyms :Increased INR; Increased international normalised ratio; Increased international normalized ratio; Low factor II activity; Prolonged PT; Reduced factor II activity; Reduced prothrombin activity; increased international normalised ratio\n"}


{'id': 'HP_0008153', 'url': 'http://purl.obolibrary.org/obo/HP_0008153', 'lbl': 'Periodic hypokalemic paresis', 'desc': 'label: Periodic hypokalemic paresis\ndefinition : Episodes of muscle weakness associated with reduced levels of potassium in the blood.\nsynonyms :Hypokalemic periodic paresis\n'}


{'id': 'HP_0008155', 'url': 'http://purl.obolibrary.org/obo/HP_0008155', 'lbl': 'Mucopolysacchariduria', 'desc': 'label: Mucopolysacchariduria\ndefinition : Excessive amounts of mucopolysaccharide in the urine.\nsynonyms :\n'}


{'id': 'HP_0008158', 'url': 'http://purl.obolibrary.org/obo/HP_0008158', 'lbl': 'Hyperapobetalipoproteinemia', 'desc': 'label: Hyperapobetalipoproteinemia\ndefinition : Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein.\nsynonyms :\n'}


{'id': 'HP_0008160', 'url': 'http://purl.obolibrary.org/obo/HP_0008160', 'lbl': '3-hydroxydicarboxylic aciduria', 'desc': 'label: 3-hydroxydicarboxylic aciduria\ndefinition : An increase in the level of 3-hydroxydicarboxylic acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0008161', 'url': 'http://purl.obolibrary.org/obo/HP_0008161', 'lbl': 'Absent leukocyte alkaline phosphatase', 'desc': 'label: Absent leukocyte alkaline phosphatase\ndefinition : Alkaline phosphatase levels measured within leukocytes is below detectable levels.\nsynonyms :Absent leukocyte ALP\n'}


{'id': 'HP_0008162', 'url': 'http://purl.obolibrary.org/obo/HP_0008162', 'lbl': 'Asymptomatic hyperammonemia', 'desc': 'label: Asymptomatic hyperammonemia\ndefinition : An increased concentration of ammonia in the blood not associated with symptoms such as encephalopathy.\nsynonyms :Hyperammonemia, asymptomatic\n'}


{'id': 'HP_0008163', 'url': 'http://purl.obolibrary.org/obo/HP_0008163', 'lbl': 'Decreased circulating cortisol level', 'desc': 'label: Decreased circulating cortisol level\ndefinition : Abnormally reduced concentration of cortisol in the blood.\nsynonyms :Decreased cortisol production; Glucocorticoid insufficiency; Hypocortisolemia; Low blood cortisol level; Low to undetectable plasma cortisol; Plasma cortisol low; Hypocortisolism\n'}


{'id': 'HP_0008165', 'url': 'http://purl.obolibrary.org/obo/HP_0008165', 'lbl': 'Decreased helper T cell proportion', 'desc': 'label: Decreased helper T cell proportion\ndefinition : Reduced proportion of helper T cells relative to the total number of T cells.\nsynonyms :Decreased proportion circulating T-helper cells; Reduced helper T cell proportion\n'}


{'id': 'HP_0008166', 'url': 'http://purl.obolibrary.org/obo/HP_0008166', 'lbl': 'Decreased beta-galactosidase activity', 'desc': 'label: Decreased beta-galactosidase activity\ndefinition : Abnormally decreased rate of beta-galactosidase activity. Beta-galactosidase activity can be measured in leukocyte, fibroblast, or plasma.\nsynonyms :Beta-galactosidase deficiency in fibroblasts and white blood cells; Beta-galactosidase-1 deficiency; Decreased beta galactosidase activity\n'}


{'id': 'HP_0008167', 'url': 'http://purl.obolibrary.org/obo/HP_0008167', 'lbl': 'Very long chain fatty acid accumulation', 'desc': 'label: Very long chain fatty acid accumulation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008169', 'url': 'http://purl.obolibrary.org/obo/HP_0008169', 'lbl': 'Reduced factor VII activity', 'desc': 'label: Reduced factor VII activity\ndefinition : Reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X.\nsynonyms :Factor VII deficiency\n'}


{'id': 'HP_0008176', 'url': 'http://purl.obolibrary.org/obo/HP_0008176', 'lbl': 'Neonatal unconjugated hyperbilirubinemia', 'desc': 'label: Neonatal unconjugated hyperbilirubinemia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008178', 'url': 'http://purl.obolibrary.org/obo/HP_0008178', 'lbl': 'Abnormal cartilage matrix', 'desc': 'label: Abnormal cartilage matrix\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008179', 'url': 'http://purl.obolibrary.org/obo/HP_0008179', 'lbl': 'Decreased Arden ratio of electrooculogram', 'desc': 'label: Decreased Arden ratio of electrooculogram\ndefinition : An abnormal reduction in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record.\nsynonyms :Decreased Arden ratio of EOG\n'}


{'id': 'HP_0008180', 'url': 'http://purl.obolibrary.org/obo/HP_0008180', 'lbl': 'Mildly elevated creatine kinase', 'desc': 'label: Mildly elevated creatine kinase\ndefinition : \nsynonyms :Mildly elevated CPK; Mildly elevated creatine phosphokinase; Mildly elevated serum CK; Mildly elevated serum CPK; Mildly elevated serum phospho-CK; Mildly increased creatine kinase; Mildly increased serum creatine kinase; Moderately elevated serum CK; Moderately elevated serum CPK; Moderately increased serum creatine kinase\n'}


{'id': 'HP_0008181', 'url': 'http://purl.obolibrary.org/obo/HP_0008181', 'lbl': 'Abetalipoproteinemia', 'desc': 'label: Abetalipoproteinemia\ndefinition : An absence of low-density lipoprotein cholesterol in the blood.\nsynonyms :\n'}


{'id': 'HP_0008182', 'url': 'http://purl.obolibrary.org/obo/HP_0008182', 'lbl': 'Adrenocortical hypoplasia', 'desc': 'label: Adrenocortical hypoplasia\ndefinition : \nsynonyms :Small adrenal cortex\n'}


{'id': 'HP_0008185', 'url': 'http://purl.obolibrary.org/obo/HP_0008185', 'lbl': 'Precocious puberty in males', 'desc': 'label: Precocious puberty in males\ndefinition : The onset of puberty before the age of 9 years in boys.\nsynonyms :Early onset of puberty in males; Male precocious puberty\n'}


{'id': 'HP_0008186', 'url': 'http://purl.obolibrary.org/obo/HP_0008186', 'lbl': 'Adrenocortical cytomegaly', 'desc': 'label: Adrenocortical cytomegaly\ndefinition : The presence of large polyhedral cells with eosinophilic granular cytoplasm and enlarged nuclei in the adrenal cortex.\nsynonyms :\n'}


{'id': 'HP_0008187', 'url': 'http://purl.obolibrary.org/obo/HP_0008187', 'lbl': 'Absence of secondary sex characteristics', 'desc': 'label: Absence of secondary sex characteristics\ndefinition : No secondary sexual characteristics are present at puberty.\nsynonyms :No secondary sexual characteristics at puberty\n'}


{'id': 'HP_0008188', 'url': 'http://purl.obolibrary.org/obo/HP_0008188', 'lbl': 'Thyroid dysgenesis', 'desc': 'label: Thyroid dysgenesis\ndefinition : \nsynonyms :Thyroid dysplasia\n'}


{'id': 'HP_0008189', 'url': 'http://purl.obolibrary.org/obo/HP_0008189', 'lbl': 'Insulin insensitivity', 'desc': 'label: Insulin insensitivity\ndefinition : Decreased sensitivity toward insulin.\nsynonyms :\n'}


{'id': 'HP_0008191', 'url': 'http://purl.obolibrary.org/obo/HP_0008191', 'lbl': 'Thyroid agenesis', 'desc': 'label: Thyroid agenesis\ndefinition : The congenital absence of the thyroid gland.\nsynonyms :Athyroidal hypothyroidism\n'}


{'id': 'HP_0008193', 'url': 'http://purl.obolibrary.org/obo/HP_0008193', 'lbl': 'Primary gonadal insufficiency', 'desc': 'label: Primary gonadal insufficiency\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008194', 'url': 'http://purl.obolibrary.org/obo/HP_0008194', 'lbl': 'Multiple pancreatic beta-cell adenomas', 'desc': 'label: Multiple pancreatic beta-cell adenomas\ndefinition : The presence of multiple pancreatic islet cell adenomas.\nsynonyms :\n'}


{'id': 'HP_0008197', 'url': 'http://purl.obolibrary.org/obo/HP_0008197', 'lbl': 'Absence of pubertal development', 'desc': 'label: Absence of pubertal development\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008198', 'url': 'http://purl.obolibrary.org/obo/HP_0008198', 'lbl': 'Congenital hypoparathyroidism', 'desc': 'label: Congenital hypoparathyroidism\ndefinition : Deficiency of parathyroid hormone with congenital onset.\nsynonyms :Neonatal hypoparathyroidism\n'}


{'id': 'HP_0008200', 'url': 'http://purl.obolibrary.org/obo/HP_0008200', 'lbl': 'Primary hyperparathyroidism', 'desc': 'label: Primary hyperparathyroidism\ndefinition : A type of hyperparathyroidism caused by a primary abnormality of the parathyroid glands (e.g., adenoma, carcinoma, hyperplasia). Primary hyperparathyroidism is associated with hyercalcemia.\nsynonyms :\n'}


{'id': 'HP_0008202', 'url': 'http://purl.obolibrary.org/obo/HP_0008202', 'lbl': 'Reduced circulating prolactin concentration', 'desc': 'label: Reduced circulating prolactin concentration\ndefinition : A reduced level of prolactin in the blood circulation. Prolactin is a protein hormone that is secreted by lactotrophs in the anterior pituitary and that stimulates mammary gland development and milk production.\nsynonyms :Prolactin deficiency\n'}


{'id': 'HP_0008204', 'url': 'http://purl.obolibrary.org/obo/HP_0008204', 'lbl': 'Precocious puberty with Sertoli cell tumor', 'desc': 'label: Precocious puberty with Sertoli cell tumor\ndefinition : \nsynonyms :Precocious puberty with Sertoli cell tumour\n'}


{'id': 'HP_0008205', 'url': 'http://purl.obolibrary.org/obo/HP_0008205', 'lbl': 'Insulin-dependent but ketosis-resistant diabetes', 'desc': 'label: Insulin-dependent but ketosis-resistant diabetes\ndefinition : Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin.\nsynonyms :\n'}


{'id': 'HP_0008207', 'url': 'http://purl.obolibrary.org/obo/HP_0008207', 'lbl': 'Primary adrenal insufficiency', 'desc': "label: Primary adrenal insufficiency\ndefinition : Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves.\nsynonyms :Adrenocortical insufficiency; Primary adrenocortical failure; Addison disease; Addison's disease\n"}


{'id': 'HP_0008208', 'url': 'http://purl.obolibrary.org/obo/HP_0008208', 'lbl': 'Parathyroid hyperplasia', 'desc': 'label: Parathyroid hyperplasia\ndefinition : Hyperplasia of the parathyroid gland.\nsynonyms :Enlarged parathyroid glands\n'}


{'id': 'HP_0008209', 'url': 'http://purl.obolibrary.org/obo/HP_0008209', 'lbl': 'Premature ovarian insufficiency', 'desc': 'label: Premature ovarian insufficiency\ndefinition : Amenorrhea due to loss of ovarian function before the age of 40. Primary ovarian inssuficiency (POI) is a state of female hypergonadotropic hypogonadism. It can manifest as primary amenorrhea with onset before menarche or secondary amenorrhea.\nsynonyms :Climacterium praecox; Early menopause; Hypergonadotropic amenorrhea; Menopause praecox; Premature menopause; Premature ovarian failure; Primary ovarian insufficiency\n'}


{'id': 'HP_0008211', 'url': 'http://purl.obolibrary.org/obo/HP_0008211', 'lbl': 'Parathyroid agenesis', 'desc': 'label: Parathyroid agenesis\ndefinition : Aplasia of the parathyroid gland.\nsynonyms :Parathyroid absence; Parathyroid aplasia\n'}


{'id': 'HP_0008213', 'url': 'http://purl.obolibrary.org/obo/HP_0008213', 'lbl': 'Gonadotropin deficiency', 'desc': 'label: Gonadotropin deficiency\ndefinition : A reduced ability to secrete gonadotropins, which are protein hormones secreted by gonadotrope cells of the anterior pituitary gland, including the hormones follitropin (FSH) and luteinizing hormone (LH).\nsynonyms :Pituitary gonadotropin deficiency\n'}


{'id': 'HP_0008214', 'url': 'http://purl.obolibrary.org/obo/HP_0008214', 'lbl': 'Decreased serum estradiol', 'desc': 'label: Decreased serum estradiol\ndefinition : A reduction below normal concentration of estradiol in the circulation.\nsynonyms :Decreased serum estradiol\n'}


{'id': 'HP_0008216', 'url': 'http://purl.obolibrary.org/obo/HP_0008216', 'lbl': 'Adrenal gland dysgenesis', 'desc': 'label: Adrenal gland dysgenesis\ndefinition : Abnormal development of the adrenal gland.\nsynonyms :Adrenal gland dysplasia; Dysplastic adrenal glands\n'}


{'id': 'HP_0008221', 'url': 'http://purl.obolibrary.org/obo/HP_0008221', 'lbl': 'Adrenal hyperplasia', 'desc': 'label: Adrenal hyperplasia\ndefinition : Enlargement of the adrenal gland.\nsynonyms :Enlarged adrenal glands\n'}


{'id': 'HP_0008222', 'url': 'http://purl.obolibrary.org/obo/HP_0008222', 'lbl': 'Female infertility', 'desc': 'label: Female infertility\ndefinition : \nsynonyms :Female infertility\n'}


{'id': 'HP_0008223', 'url': 'http://purl.obolibrary.org/obo/HP_0008223', 'lbl': 'Compensated hypothyroidism', 'desc': 'label: Compensated hypothyroidism\ndefinition : Condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4).\nsynonyms :Mild hypothyroidism; Subclinical hypothyroidism\n'}


{'id': 'HP_0008225', 'url': 'http://purl.obolibrary.org/obo/HP_0008225', 'lbl': 'Thyroid follicular hyperplasia', 'desc': 'label: Thyroid follicular hyperplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008226', 'url': 'http://purl.obolibrary.org/obo/HP_0008226', 'lbl': 'Androgen insufficiency', 'desc': 'label: Androgen insufficiency\ndefinition : Insufficient amount of androgenic activity.\nsynonyms :Hypoandrogenism\n'}


{'id': 'HP_0008227', 'url': 'http://purl.obolibrary.org/obo/HP_0008227', 'lbl': 'Pituitary resistance to thyroid hormone', 'desc': 'label: Pituitary resistance to thyroid hormone\ndefinition : A condition in which the pituitary gland is partially resistant to thyroid hormone, so that it continues to secrete thyroid-stimulating hormone (TSH) until the blood level of thyroid hormone rises higher than normal.\nsynonyms :\n'}


{'id': 'HP_0008229', 'url': 'http://purl.obolibrary.org/obo/HP_0008229', 'lbl': 'Thyroid lymphangiectasia', 'desc': 'label: Thyroid lymphangiectasia\ndefinition : The presence of lymphangiectasis of the thyroid gland.\nsynonyms :Thyroid lymphangiectasis\n'}


{'id': 'HP_0008230', 'url': 'http://purl.obolibrary.org/obo/HP_0008230', 'lbl': 'obsolete Decreased testosterone in males', 'desc': 'label: obsolete Decreased testosterone in males\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008231', 'url': 'http://purl.obolibrary.org/obo/HP_0008231', 'lbl': 'Macronodular adrenal hyperplasia', 'desc': 'label: Macronodular adrenal hyperplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008232', 'url': 'http://purl.obolibrary.org/obo/HP_0008232', 'lbl': 'Elevated circulating follicle stimulating hormone level', 'desc': 'label: Elevated circulating follicle stimulating hormone level\ndefinition : An elevated concentration of follicle-stimulating hormone in the blood.\nsynonyms :Elevated FSH level; Elevated follicle stimulating hormone; Elevated follicle-stimulating hormone; Elevated plasma follicle stimulating hormone; Increased circulating follicle stimulating hormone level\n'}


{'id': 'HP_0008233', 'url': 'http://purl.obolibrary.org/obo/HP_0008233', 'lbl': 'Decreased circulating progesterone', 'desc': 'label: Decreased circulating progesterone\ndefinition : An reduced concentration of progesterone in the blood.\nsynonyms :Decreased serum progesterone\n'}


{'id': 'HP_0008236', 'url': 'http://purl.obolibrary.org/obo/HP_0008236', 'lbl': 'Isosexual precocious puberty', 'desc': 'label: Isosexual precocious puberty\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008237', 'url': 'http://purl.obolibrary.org/obo/HP_0008237', 'lbl': 'Hypothalamic hypothyroidism', 'desc': 'label: Hypothalamic hypothyroidism\ndefinition : A type of hypothyroidism that results from a defect in thyrotropin-releasing hormone activity.\nsynonyms :Tertiary hypothyroidism\n'}


{'id': 'HP_0008239', 'url': 'http://purl.obolibrary.org/obo/HP_0008239', 'lbl': 'Adrenal medullary hypoplasia', 'desc': 'label: Adrenal medullary hypoplasia\ndefinition : Developmental hypoplasia of the adrenal medulla.\nsynonyms :Small adrenal medulla\n'}


{'id': 'HP_0008240', 'url': 'http://purl.obolibrary.org/obo/HP_0008240', 'lbl': 'Secondary growth hormone deficiency', 'desc': 'label: Secondary growth hormone deficiency\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008242', 'url': 'http://purl.obolibrary.org/obo/HP_0008242', 'lbl': 'Pseudohypoaldosteronism', 'desc': 'label: Pseudohypoaldosteronism\ndefinition : A state of renal tubular unresponsiveness or resistance to the action of aldosterone.\nsynonyms :\n'}


{'id': 'HP_0008244', 'url': 'http://purl.obolibrary.org/obo/HP_0008244', 'lbl': 'Congenital adrenal hypoplasia', 'desc': 'label: Congenital adrenal hypoplasia\ndefinition : A type of adrenal hypoplasia with congenital onset.\nsynonyms :Congenital adrenal gland hypoplasia\n'}


{'id': 'HP_0008245', 'url': 'http://purl.obolibrary.org/obo/HP_0008245', 'lbl': 'Pituitary hypothyroidism', 'desc': 'label: Pituitary hypothyroidism\ndefinition : A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion.\nsynonyms :Low thyroid gland function due to abnormal pituitary gland; Secondary hypothyroidism; TSH deficient hypothyroidism; Thyroid stimulating hormone deficiency; Thyrotropin deficiency\n'}


{'id': 'HP_0008247', 'url': 'http://purl.obolibrary.org/obo/HP_0008247', 'lbl': 'Euthyroid hyperthyroxinemia', 'desc': 'label: Euthyroid hyperthyroxinemia\ndefinition : Increased levels of thyroxine without evidence of clinical thyroid disease.\nsynonyms :Asymptomatic hyperthyroxinemia\n'}


{'id': 'HP_0008249', 'url': 'http://purl.obolibrary.org/obo/HP_0008249', 'lbl': 'Thyroid hyperplasia', 'desc': 'label: Thyroid hyperplasia\ndefinition : Hyperplasia of the thyroid gland.\nsynonyms :Large thyroid\n'}


{'id': 'HP_0008250', 'url': 'http://purl.obolibrary.org/obo/HP_0008250', 'lbl': 'obsolete Infantile hypercalcemia', 'desc': 'label: obsolete Infantile hypercalcemia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008251', 'url': 'http://purl.obolibrary.org/obo/HP_0008251', 'lbl': 'Congenital goiter', 'desc': 'label: Congenital goiter\ndefinition : An enlargement of the thyroid gland with congenital onset.\nsynonyms :Congenital goitre\n'}


{'id': 'HP_0008255', 'url': 'http://purl.obolibrary.org/obo/HP_0008255', 'lbl': 'Transient neonatal diabetes mellitus', 'desc': 'label: Transient neonatal diabetes mellitus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008256', 'url': 'http://purl.obolibrary.org/obo/HP_0008256', 'lbl': 'Adrenocortical adenoma', 'desc': 'label: Adrenocortical adenoma\ndefinition : Adrenocortical adenomas are benign tumors of the adrenal cortex.\nsynonyms :Adrenocortical adenomas\n'}


{'id': 'HP_0008258', 'url': 'http://purl.obolibrary.org/obo/HP_0008258', 'lbl': 'Congenital adrenal hyperplasia', 'desc': 'label: Congenital adrenal hyperplasia\ndefinition : A type of adrenal hyperplasia with congenital onset.\nsynonyms :\n'}


{'id': 'HP_0008259', 'url': 'http://purl.obolibrary.org/obo/HP_0008259', 'lbl': 'Adrenocorticotropin receptor defect', 'desc': 'label: Adrenocorticotropin receptor defect\ndefinition : Adrenal insufficiency secondary to a defect in the ACTH receptor.\nsynonyms :ACTH receptor defect; ACTHR defect; Adrenocorticotropic hormone-resistant adrenal insufficiency\n'}


{'id': 'HP_0008261', 'url': 'http://purl.obolibrary.org/obo/HP_0008261', 'lbl': 'Pancreatic islet cell adenoma', 'desc': 'label: Pancreatic islet cell adenoma\ndefinition : The presence of an adenoma of the pancreas with origin in a pancreatic B cell.\nsynonyms :\n'}


{'id': 'HP_0008263', 'url': 'http://purl.obolibrary.org/obo/HP_0008263', 'lbl': 'Thyroid defect in oxidation and organification of iodide', 'desc': 'label: Thyroid defect in oxidation and organification of iodide\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008264', 'url': 'http://purl.obolibrary.org/obo/HP_0008264', 'lbl': 'Neutrophil inclusion bodies', 'desc': 'label: Neutrophil inclusion bodies\ndefinition : The presence of intracellular inclusion bodies (aggregates of stainable substances, usually proteins) in neutrophils. Cytoplasmic neutrophil inclusions (oval, basophilic) are also known as Doehle bodies.\nsynonyms :\n'}


{'id': 'HP_0008265', 'url': 'http://purl.obolibrary.org/obo/HP_0008265', 'lbl': 'Mitochondrial lysine transport defect', 'desc': 'label: Mitochondrial lysine transport defect\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008269', 'url': 'http://purl.obolibrary.org/obo/HP_0008269', 'lbl': 'Increased red cell hemolysis by shear stress', 'desc': 'label: Increased red cell hemolysis by shear stress\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008271', 'url': 'http://purl.obolibrary.org/obo/HP_0008271', 'lbl': 'Abnormal cartilage collagen', 'desc': 'label: Abnormal cartilage collagen\ndefinition : Abnormal morphology of collagen fibers in cartilage. In cartilage, collagen II, actually a collagen II:IX:XI heterofibril, is by far the most important type of collagen. A number of abnormalities may be appreciated by electron micrography or biochemical investigations, including sparse collagen fibers in the cartilage matrix.\nsynonyms :Abnormal hyaline collagen; Abnormal type II collagen\n'}


{'id': 'HP_0008272', 'url': 'http://purl.obolibrary.org/obo/HP_0008272', 'lbl': 'Renal tubular lysine transport defect', 'desc': 'label: Renal tubular lysine transport defect\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008273', 'url': 'http://purl.obolibrary.org/obo/HP_0008273', 'lbl': 'Transient aminoaciduria', 'desc': 'label: Transient aminoaciduria\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008275', 'url': 'http://purl.obolibrary.org/obo/HP_0008275', 'lbl': 'Abnormal light-adapted electroretinogram', 'desc': 'label: Abnormal light-adapted electroretinogram\ndefinition : \nsynonyms :Abnormal cone-mediated electroretinogram\n'}


{'id': 'HP_0008277', 'url': 'http://purl.obolibrary.org/obo/HP_0008277', 'lbl': 'Abnormal blood zinc concentration', 'desc': 'label: Abnormal blood zinc concentration\ndefinition : An abnormality of zinc ion homeostasis.\nsynonyms :Abnormality of zinc homeostasis; Abnormal zinc metabolism\n'}


{'id': 'HP_0008278', 'url': 'http://purl.obolibrary.org/obo/HP_0008278', 'lbl': 'Cerebellar cortical atrophy', 'desc': 'label: Cerebellar cortical atrophy\ndefinition : Atrophy (wasting) of the cerebellar cortex.\nsynonyms :Cerebellar cortex degeneration\n'}


{'id': 'HP_0008279', 'url': 'http://purl.obolibrary.org/obo/HP_0008279', 'lbl': 'Transient hyperlipidemia', 'desc': 'label: Transient hyperlipidemia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008281', 'url': 'http://purl.obolibrary.org/obo/HP_0008281', 'lbl': 'Acute hyperammonemia', 'desc': 'label: Acute hyperammonemia\ndefinition : An increased concentration of ammonia in the blood with sudden onset.\nsynonyms :Hyperammonemia, acute\n'}


{'id': 'HP_0008282', 'url': 'http://purl.obolibrary.org/obo/HP_0008282', 'lbl': 'Unconjugated hyperbilirubinemia', 'desc': 'label: Unconjugated hyperbilirubinemia\ndefinition : An increased amount of unconjugated (indirect) bilurubin in the blood.\nsynonyms :\n'}


{'id': 'HP_0008283', 'url': 'http://purl.obolibrary.org/obo/HP_0008283', 'lbl': 'Fasting hyperinsulinemia', 'desc': 'label: Fasting hyperinsulinemia\ndefinition : An increased concentration of insulin in the blood in the fasting state, i.e., not as the response to food intake.\nsynonyms :High blood insulin levels while fasting\n'}


{'id': 'HP_0008285', 'url': 'http://purl.obolibrary.org/obo/HP_0008285', 'lbl': 'Transient hypophosphatemia', 'desc': 'label: Transient hypophosphatemia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008288', 'url': 'http://purl.obolibrary.org/obo/HP_0008288', 'lbl': 'Nonketotic hyperglycinemia', 'desc': 'label: Nonketotic hyperglycinemia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008290', 'url': 'http://purl.obolibrary.org/obo/HP_0008290', 'lbl': 'Partial complement factor H deficiency', 'desc': 'label: Partial complement factor H deficiency\ndefinition : A partial reduction in level of the complement component Factor H in circulation.\nsynonyms :\n'}


{'id': 'HP_0008291', 'url': 'http://purl.obolibrary.org/obo/HP_0008291', 'lbl': 'Pituitary corticotropic cell adenoma', 'desc': 'label: Pituitary corticotropic cell adenoma\ndefinition : A type of pituitary adenoma that produces adrenocorticotropic hormone (ACTH).\nsynonyms :ACTH-producing pituitary adenoma; Corticotropin-secreting pituitary adenoma\n'}


{'id': 'HP_0008293', 'url': 'http://purl.obolibrary.org/obo/HP_0008293', 'lbl': 'Long-chain dicarboxylic aciduria', 'desc': 'label: Long-chain dicarboxylic aciduria\ndefinition : An increase in the level of long-chain dicarboxylic acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0008297', 'url': 'http://purl.obolibrary.org/obo/HP_0008297', 'lbl': 'Transient hyperphenylalaninemia', 'desc': 'label: Transient hyperphenylalaninemia\ndefinition : A condition of not having consistently high levels of phenylalanine in the blood but of experiencing temporary hyperphenylalaninemia following ingestion of large quantities of phenylalanine (for instance, following an oral loading test with phenylalanine).\nsynonyms :\n'}


{'id': 'HP_0008301', 'url': 'http://purl.obolibrary.org/obo/HP_0008301', 'lbl': 'Dermatan sulfate excretion in urine', 'desc': 'label: Dermatan sulfate excretion in urine\ndefinition : An increased concentration of dermatan sulfate in the urine.\nsynonyms :Dermatan sulphate excretion in urine\n'}


{'id': 'HP_0008303', 'url': 'http://purl.obolibrary.org/obo/HP_0008303', 'lbl': 'Olivary degeneration', 'desc': 'label: Olivary degeneration\ndefinition : Degeneration of the olivary bodies, prominent oval structures in the medulla oblongata.\nsynonyms :\n'}


{'id': 'HP_0008305', 'url': 'http://purl.obolibrary.org/obo/HP_0008305', 'lbl': 'Exercise-induced myoglobinuria', 'desc': 'label: Exercise-induced myoglobinuria\ndefinition : Presence of myoglobin in the urine following exercise.\nsynonyms :Exercise-induced myoglobinuria in adults\n'}


{'id': 'HP_0008306', 'url': 'http://purl.obolibrary.org/obo/HP_0008306', 'lbl': 'Abnormal iron deposition in mitochondria', 'desc': 'label: Abnormal iron deposition in mitochondria\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008309', 'url': 'http://purl.obolibrary.org/obo/HP_0008309', 'lbl': 'Medium chain dicarboxylic aciduria', 'desc': 'label: Medium chain dicarboxylic aciduria\ndefinition : An increase in the level of medium chain dicarboxylic acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0008311', 'url': 'http://purl.obolibrary.org/obo/HP_0008311', 'lbl': 'Spinal cord posterior columns myelin loss', 'desc': 'label: Spinal cord posterior columns myelin loss\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008314', 'url': 'http://purl.obolibrary.org/obo/HP_0008314', 'lbl': 'Decreased activity of mitochondrial complex II', 'desc': 'label: Decreased activity of mitochondrial complex II\ndefinition : A reduction in the activity of the mitochondrial respiratory chain complex II, which is part of the electron transport chain in mitochondria.\nsynonyms :Respiratory complex II deficiency\n'}


{'id': 'HP_0008315', 'url': 'http://purl.obolibrary.org/obo/HP_0008315', 'lbl': 'Decreased plasma free carnitine', 'desc': 'label: Decreased plasma free carnitine\ndefinition : A decreased concentration of free (unbound) carnitine in the blood.\nsynonyms :\n'}


{'id': 'HP_0008316', 'url': 'http://purl.obolibrary.org/obo/HP_0008316', 'lbl': 'Abnormal mitochondria in muscle tissue', 'desc': 'label: Abnormal mitochondria in muscle tissue\ndefinition : An abnormality of the mitochondria in muscle tissue.\nsynonyms :Abnormal mitochondria in muscle\n'}


{'id': 'HP_0008318', 'url': 'http://purl.obolibrary.org/obo/HP_0008318', 'lbl': 'Elevated leukocyte alkaline phosphatase', 'desc': 'label: Elevated leukocyte alkaline phosphatase\ndefinition : Increased alkaline phosphatase measured within leukocytes.\nsynonyms :Elevated leukocyte ALP\n'}


{'id': 'HP_0008320', 'url': 'http://purl.obolibrary.org/obo/HP_0008320', 'lbl': 'Impaired collagen-induced platelet aggregation', 'desc': 'label: Impaired collagen-induced platelet aggregation\ndefinition : Abnormal response to collagen or collagen-mimetics as manifested by reduced or lacking aggregation of platelets upon addition collagen or collagen-mimetics.\nsynonyms :\n'}


{'id': 'HP_0008321', 'url': 'http://purl.obolibrary.org/obo/HP_0008321', 'lbl': 'Reduced factor X activity', 'desc': 'label: Reduced factor X activity\ndefinition : Reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa).\nsynonyms :Decreased factor x activity; Factor X deficiency\n'}


{'id': 'HP_0008322', 'url': 'http://purl.obolibrary.org/obo/HP_0008322', 'lbl': 'Abnormal mitochondrial morphology', 'desc': 'label: Abnormal mitochondrial morphology\ndefinition : Any structural anomaly of the mitochondria.\nsynonyms :Abnormal mitochondrion morphology\n'}


{'id': 'HP_0008323', 'url': 'http://purl.obolibrary.org/obo/HP_0008323', 'lbl': 'Abnormal light- and dark-adapted electroretinogram', 'desc': 'label: Abnormal light- and dark-adapted electroretinogram\ndefinition : An abnormality of the combined rod-and-cone response on electroretinogram.\nsynonyms :Abnormal rod and cone electroretinogram\n'}


{'id': 'HP_0008326', 'url': 'http://purl.obolibrary.org/obo/HP_0008326', 'lbl': 'Reduced circulating vitamin B6 level', 'desc': 'label: Reduced circulating vitamin B6 level\ndefinition : An abnormally decreased concentration of vitamin B6 in the blood circulation.\nsynonyms :Reduced vitamin b6 levels; Vitamin B6 deficiency\n'}


{'id': 'HP_0008327', 'url': 'http://purl.obolibrary.org/obo/HP_0008327', 'lbl': 'Microscopic nephrocalcinosis', 'desc': 'label: Microscopic nephrocalcinosis\ndefinition : The presence of microscopic crystalline calcium precipitates in the form of oxalate and/or phosphate in the renal parenchyma.\nsynonyms :\n'}


{'id': 'HP_0008330', 'url': 'http://purl.obolibrary.org/obo/HP_0008330', 'lbl': 'Reduced von Willebrand factor activity', 'desc': 'label: Reduced von Willebrand factor activity\ndefinition : Decreased activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces.\nsynonyms :Decreased von willebrand factor activity\n'}


{'id': 'HP_0008331', 'url': 'http://purl.obolibrary.org/obo/HP_0008331', 'lbl': 'Elevated creatine kinase after exercise', 'desc': 'label: Elevated creatine kinase after exercise\ndefinition : \nsynonyms :Elevated CK after exercise; Elevated CPK after exercise; Elevated creatine phosphokinase after exercise; Elevated phospho-CK after exercise; Elevated phospho-creatine kinase after exercise; Increased CK after exercise; Increased creatine kinase after exercise; Increased creatine phosphokinase after exercise; Increased phospho-CK after exercise; Increased phospho-creatine kinase after exercise\n'}


{'id': 'HP_0008335', 'url': 'http://purl.obolibrary.org/obo/HP_0008335', 'lbl': 'obsolete Renal aminoaciduria', 'desc': 'label: obsolete Renal aminoaciduria\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008336', 'url': 'http://purl.obolibrary.org/obo/HP_0008336', 'lbl': 'Complex organic aciduria', 'desc': 'label: Complex organic aciduria\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008338', 'url': 'http://purl.obolibrary.org/obo/HP_0008338', 'lbl': 'Partial functional complement factor D deficiency', 'desc': 'label: Partial functional complement factor D deficiency\ndefinition : A partial reduction in level of the complement component Factor D in circulation.\nsynonyms :Partial functional adipsin deficiency; Partial functional factor d deficiency\n'}


{'id': 'HP_0008339', 'url': 'http://purl.obolibrary.org/obo/HP_0008339', 'lbl': 'Diaminoaciduria', 'desc': 'label: Diaminoaciduria\ndefinition : An increased urine level of any amino acid carrying two amino groups (Asparagine, glutamine and lysine, cystine, ornithine).\nsynonyms :\n'}


{'id': 'HP_0008341', 'url': 'http://purl.obolibrary.org/obo/HP_0008341', 'lbl': 'Distal renal tubular acidosis', 'desc': 'label: Distal renal tubular acidosis\ndefinition : A type of renal tubular acidosis characterized by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct of the distal nephron. The urine cannot be acidified below a pH of 5.3, associated with acidemia and hypokalemia.\nsynonyms :Renal tubular acidosis, type I\n'}


{'id': 'HP_0008344', 'url': 'http://purl.obolibrary.org/obo/HP_0008344', 'lbl': 'Elevated circulating branched chain amino acid concentration', 'desc': 'label: Elevated circulating branched chain amino acid concentration\ndefinition : Concentration of a branched chain amino acid in the blood above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0008345', 'url': 'http://purl.obolibrary.org/obo/HP_0008345', 'lbl': 'Hypoplasia of the iris dilator muscle', 'desc': 'label: Hypoplasia of the iris dilator muscle\ndefinition : Underdevelopment of the dilatator pupillae.\nsynonyms :Hypoplasia of the pupil dilator muscle; Underdeveloped iris dilator muscle; Underdeveloped pupil dilator muscle\n'}


{'id': 'HP_0008346', 'url': 'http://purl.obolibrary.org/obo/HP_0008346', 'lbl': 'Increased red cell sickling tendency', 'desc': 'label: Increased red cell sickling tendency\ndefinition : \nsynonyms :Increased sickling of erythrocytes; Increased sickling of red cells\n'}


{'id': 'HP_0008347', 'url': 'http://purl.obolibrary.org/obo/HP_0008347', 'lbl': 'Decreased activity of mitochondrial complex IV', 'desc': 'label: Decreased activity of mitochondrial complex IV\ndefinition : A reduction in the activity of the mitochondrial respiratory chain complex IV, which is part of the electron transport chain in mitochondria.\nsynonyms :Respiratory complex IV deficiency\n'}


{'id': 'HP_0008348', 'url': 'http://purl.obolibrary.org/obo/HP_0008348', 'lbl': 'Decreased circulating IgG2 level', 'desc': 'label: Decreased circulating IgG2 level\ndefinition : A reduction in immunoglobulin levels of the IgG2 subclass in the blood circulation.\nsynonyms :Decreased IgG2 level in blood; Immunoglobulin IgG2 deficiency; Reduced IgG2 levels\n'}


{'id': 'HP_0008352', 'url': 'http://purl.obolibrary.org/obo/HP_0008352', 'lbl': 'Impaired platelet adhesion', 'desc': 'label: Impaired platelet adhesion\ndefinition : An abnormality of adhesion of thrombocytes. Normally, platelets adhere to collagen in the vascular subendothelium within seconds of injury via a receptor made up of glycoprotein Ia and IIa and GPVI and to vWF via receptor GPIb/IX/V. The adherent platelets then release granules that lead to platelet activation and aggregation.\nsynonyms :Impaired thrombocytes adhesion\n'}


{'id': 'HP_0008353', 'url': 'http://purl.obolibrary.org/obo/HP_0008353', 'lbl': 'Neutral hyperaminoaciduria', 'desc': 'label: Neutral hyperaminoaciduria\ndefinition : The presence of an abnormally increased concentration of neutral amino acids in the urine. The neutral amino acids are tryptophan, alanine, asparagine, glutamine, histidine, isoleucine, leucine, phenylalanine, serine, threonine, tyrosine and valine.\nsynonyms :\n'}


{'id': 'HP_0008354', 'url': 'http://purl.obolibrary.org/obo/HP_0008354', 'lbl': 'Factor X activation deficiency', 'desc': 'label: Factor X activation deficiency\ndefinition : Reduced ability to transform factor X into its activated form factor Xa.\nsynonyms :\n'}


{'id': 'HP_0008356', 'url': 'http://purl.obolibrary.org/obo/HP_0008356', 'lbl': 'obsolete Combined hyperlipidemia', 'desc': 'label: obsolete Combined hyperlipidemia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008357', 'url': 'http://purl.obolibrary.org/obo/HP_0008357', 'lbl': 'Reduced factor XIII activity', 'desc': 'label: Reduced factor XIII activity\ndefinition : Decreased activity of coagulation factor XIII (also known as fibrin stabilizing factor). Activated Factor XIII cross-links fibrin polymers solidifying the clot.\nsynonyms :\n'}


{'id': 'HP_0008358', 'url': 'http://purl.obolibrary.org/obo/HP_0008358', 'lbl': 'Hyperprolinemia', 'desc': 'label: Hyperprolinemia\ndefinition : An increased concentration of proline in the blood.\nsynonyms :Prolinemia\n'}


{'id': 'HP_0008360', 'url': 'http://purl.obolibrary.org/obo/HP_0008360', 'lbl': 'Neonatal hypoproteinemia', 'desc': 'label: Neonatal hypoproteinemia\ndefinition : A neonatal decreased concentration of proteins in the blood.\nsynonyms :\n'}


{'id': 'HP_0008361', 'url': 'http://purl.obolibrary.org/obo/HP_0008361', 'lbl': 'Corticospinal tract pallor', 'desc': 'label: Corticospinal tract pallor\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008362', 'url': 'http://purl.obolibrary.org/obo/HP_0008362', 'lbl': 'Aplasia/Hypoplasia of the hallux', 'desc': 'label: Aplasia/Hypoplasia of the hallux\ndefinition : Absence or underdevelopment of the big toe.\nsynonyms :Absent/small big toe; Absent/underdeveloped big toe; Aplastic/hypoplastic halluces\n'}


{'id': 'HP_0008363', 'url': 'http://purl.obolibrary.org/obo/HP_0008363', 'lbl': 'Aplasia/Hypoplasia of the tarsal bones', 'desc': 'label: Aplasia/Hypoplasia of the tarsal bones\ndefinition : Absence or underdevelopment of the tarsal bones.\nsynonyms :Absent/small ankle bone; Absent/underdeveloped ankle bone; Aplastic/hypoplastic tarsals\n'}


{'id': 'HP_0008364', 'url': 'http://purl.obolibrary.org/obo/HP_0008364', 'lbl': 'Abnormality of the calcaneus', 'desc': 'label: Abnormality of the calcaneus\ndefinition : An abnormality of the calcaneus, also known as the heel bone, one of the or heel bone, one of the components of the tarsus of the foot which make up the heel.\nsynonyms :Abnormal heel bone\n'}


{'id': 'HP_0008365', 'url': 'http://purl.obolibrary.org/obo/HP_0008365', 'lbl': 'Abnormal talus morphology', 'desc': 'label: Abnormal talus morphology\ndefinition : An abnormality of the talus.\nsynonyms :Abnormal large bone of ankle\n'}


{'id': 'HP_0008366', 'url': 'http://purl.obolibrary.org/obo/HP_0008366', 'lbl': 'Foot joint contracture', 'desc': 'label: Foot joint contracture\ndefinition : Contractures of one or more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue.\nsynonyms :Contractures involving the joints of the feet; Contractures of the foot joints; Joint contractures involving the joints of the feet\n'}


{'id': 'HP_0008368', 'url': 'http://purl.obolibrary.org/obo/HP_0008368', 'lbl': 'Tarsal synostosis', 'desc': 'label: Tarsal synostosis\ndefinition : Synostosis (bony fusion) involving one or more bones of the tarsus (calcaneus, talus, cuboid, navicular, cuneiiform bones).\nsynonyms :Fused ankle bones; Synostosis involving tarsal bones; Synostosis of tarsal bones; Tarsal bone fusion; Tarsal bone synostosis; Tarsal fusion; Tarsal fusions\n'}


{'id': 'HP_0008369', 'url': 'http://purl.obolibrary.org/obo/HP_0008369', 'lbl': 'Abnormal tarsal ossification', 'desc': 'label: Abnormal tarsal ossification\ndefinition : An abnormality of the formation and mineralization of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.\nsynonyms :Abnormal ossification of tarsal bones; Hardening of ankle bones; Abnormal maturation of ankle bones\n'}


{'id': 'HP_0008371', 'url': 'http://purl.obolibrary.org/obo/HP_0008371', 'lbl': 'Abnormal metatarsal ossification', 'desc': 'label: Abnormal metatarsal ossification\ndefinition : Any abnormal process of ossification of the metatarsal bones, which normally are each ossified from two centers: one for the body, and one for the head (metatarsal II,III,IV, and V) and one for the body and one for the base (metatarsal I). The ossification process begins in the center of the body about the ninth week, and extends toward either extremity. The center for the base of the first metatarsal appears about the third year, and the centers for the heads of the other bones between the fifth and eighth years. They join the bodies between the eighteenth and twentieth years.\nsynonyms :Abnormal ossification involving metatarsal bones; Abnormal maturation of long bone of foot\n'}


{'id': 'HP_0008372', 'url': 'http://purl.obolibrary.org/obo/HP_0008372', 'lbl': 'Abnormality of vitamin A metabolism', 'desc': 'label: Abnormality of vitamin A metabolism\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008373', 'url': 'http://purl.obolibrary.org/obo/HP_0008373', 'lbl': 'Puberty and gonadal disorders', 'desc': 'label: Puberty and gonadal disorders\ndefinition : \nsynonyms :Puberty and gonadal disorders\n'}


{'id': 'HP_0008376', 'url': 'http://purl.obolibrary.org/obo/HP_0008376', 'lbl': 'Nasal, dysarthic speech', 'desc': 'label: Nasal, dysarthic speech\ndefinition : \nsynonyms :Breathy speech\n'}


{'id': 'HP_0008383', 'url': 'http://purl.obolibrary.org/obo/HP_0008383', 'lbl': 'Slow-growing nails', 'desc': 'label: Slow-growing nails\ndefinition : Nails whose growth is slower than normal.\nsynonyms :Slow-growing nails\n'}


{'id': 'HP_0008386', 'url': 'http://purl.obolibrary.org/obo/HP_0008386', 'lbl': 'Aplasia/Hypoplasia of the nails', 'desc': 'label: Aplasia/Hypoplasia of the nails\ndefinition : Aplasia or developmental hypoplasia of the nail.\nsynonyms :Absent/hypoplastic nails; Absent/small nails; Absent/underdeveloped nails; Nail aplasia/hypoplasia\n'}


{'id': 'HP_0008388', 'url': 'http://purl.obolibrary.org/obo/HP_0008388', 'lbl': 'Abnormal toenail morphology', 'desc': 'label: Abnormal toenail morphology\ndefinition : An anomaly of the toenail.\nsynonyms :Abnormality of the toenail; Abnormality of the toenails\n'}


{'id': 'HP_0008390', 'url': 'http://purl.obolibrary.org/obo/HP_0008390', 'lbl': 'Recurrent loss of toenails and fingernails', 'desc': 'label: Recurrent loss of toenails and fingernails\ndefinition : Repeated loss, or shedding, of the nails of the fingers and toes.\nsynonyms :Recurrent loss of toenails and fingernails; Recurrent shedding of toenails and fingernails\n'}


{'id': 'HP_0008391', 'url': 'http://purl.obolibrary.org/obo/HP_0008391', 'lbl': 'Dystrophic fingernails', 'desc': 'label: Dystrophic fingernails\ndefinition : The presence of misshapen or partially destroyed nail plates, often with accumulation of soft, yellow keratin between the dystrophic nail plate and nail bed, resulting in elevation of the nail plate.\nsynonyms :Poor fingernail formation\n'}


{'id': 'HP_0008392', 'url': 'http://purl.obolibrary.org/obo/HP_0008392', 'lbl': 'Subungual hyperkeratosis', 'desc': 'label: Subungual hyperkeratosis\ndefinition : A thickening of the stratum corneum in the region beneath the nails.\nsynonyms :Thickened, discolored skin under nail; Thickened, discoloured skin under nail\n'}


{'id': 'HP_0008393', 'url': 'http://purl.obolibrary.org/obo/HP_0008393', 'lbl': 'Congenital curved nail of fourth toe', 'desc': 'label: Congenital curved nail of fourth toe\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008394', 'url': 'http://purl.obolibrary.org/obo/HP_0008394', 'lbl': 'Congenital onychodystrophy', 'desc': 'label: Congenital onychodystrophy\ndefinition : \nsynonyms :Congenital malformed nails\n'}


{'id': 'HP_0008396', 'url': 'http://purl.obolibrary.org/obo/HP_0008396', 'lbl': 'Chronic monilial nail infection', 'desc': 'label: Chronic monilial nail infection\ndefinition : Chronic infection of the nails by Candida species.\nsynonyms :\n'}


{'id': 'HP_0008398', 'url': 'http://purl.obolibrary.org/obo/HP_0008398', 'lbl': 'Hypoplastic fifth fingernail', 'desc': 'label: Hypoplastic fifth fingernail\ndefinition : A nail of the fifth finger that is diminished in length and width, i.e., underdeveloped nail of little finger.\nsynonyms :Underdeveloped fifth fingernail; Underdeveloped fingernail of little finger; Underdeveloped fingernail of pinkie finger; Underdeveloped fingernail of pinky finger\n'}


{'id': 'HP_0008399', 'url': 'http://purl.obolibrary.org/obo/HP_0008399', 'lbl': 'Circumungual hyperkeratosis', 'desc': 'label: Circumungual hyperkeratosis\ndefinition : A thickening of the stratum corneum, the outer layer of the skin, in the region surrounding the nails.\nsynonyms :Thick skin around nails\n'}


{'id': 'HP_0008400', 'url': 'http://purl.obolibrary.org/obo/HP_0008400', 'lbl': 'Onycholysis of distal fingernails', 'desc': 'label: Onycholysis of distal fingernails\ndefinition : Detachment of the distal fingernails from the nail bed.\nsynonyms :Detachment of outermost fingernails\n'}


{'id': 'HP_0008401', 'url': 'http://purl.obolibrary.org/obo/HP_0008401', 'lbl': 'Onychogryposis of toenails', 'desc': 'label: Onychogryposis of toenails\ndefinition : Thickened toenails.\nsynonyms :Overgrowth and curving of toenails\n'}


{'id': 'HP_0008402', 'url': 'http://purl.obolibrary.org/obo/HP_0008402', 'lbl': 'Ridged fingernail', 'desc': 'label: Ridged fingernail\ndefinition : Longitudinal, linear prominences in the fingernail plate.\nsynonyms :Longitudinally grooved fingernails; Ridged fingernail; Ridged fingernails\n'}


{'id': 'HP_0008404', 'url': 'http://purl.obolibrary.org/obo/HP_0008404', 'lbl': 'Nail dystrophy', 'desc': 'label: Nail dystrophy\ndefinition : Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate.\nsynonyms :Dystrophic nails; Onychodystrophy; Poor nail formation\n'}


{'id': 'HP_0008407', 'url': 'http://purl.obolibrary.org/obo/HP_0008407', 'lbl': 'Hyperconvex thumb nails', 'desc': 'label: Hyperconvex thumb nails\ndefinition : \nsynonyms :Tightly curved thumb nail\n'}


{'id': 'HP_0008410', 'url': 'http://purl.obolibrary.org/obo/HP_0008410', 'lbl': 'Subungual hyperkeratotic fragments', 'desc': 'label: Subungual hyperkeratotic fragments\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008414', 'url': 'http://purl.obolibrary.org/obo/HP_0008414', 'lbl': 'Lumbar kyphosis in infancy', 'desc': 'label: Lumbar kyphosis in infancy\ndefinition : \nsynonyms :Hunched back in infancy; Round back in infancy\n'}


{'id': 'HP_0008416', 'url': 'http://purl.obolibrary.org/obo/HP_0008416', 'lbl': 'Six lumbar vertebrae', 'desc': 'label: Six lumbar vertebrae\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008417', 'url': 'http://purl.obolibrary.org/obo/HP_0008417', 'lbl': 'Vertebral hypoplasia', 'desc': 'label: Vertebral hypoplasia\ndefinition : Small, underdeveloped vertebral bodies.\nsynonyms :Underdeveloped vertebrae\n'}


{'id': 'HP_0008418', 'url': 'http://purl.obolibrary.org/obo/HP_0008418', 'lbl': 'Squared-off platyspondyly', 'desc': 'label: Squared-off platyspondyly\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008419', 'url': 'http://purl.obolibrary.org/obo/HP_0008419', 'lbl': 'Intervertebral disc degeneration', 'desc': 'label: Intervertebral disc degeneration\ndefinition : The presence of degenerative changes of intervertebral disk.\nsynonyms :Degeneration of intervertebral discs; Degeneration of intervertebral disks; Degenerative disc disease; Degenerative intervertebral disc; Degenerative intervertebral disk\n'}


{'id': 'HP_0008420', 'url': 'http://purl.obolibrary.org/obo/HP_0008420', 'lbl': 'Punctate vertebral calcifications', 'desc': 'label: Punctate vertebral calcifications\ndefinition : The presence of punctiform calcification of the bone of the vertebral bodies.\nsynonyms :\n'}


{'id': 'HP_0008421', 'url': 'http://purl.obolibrary.org/obo/HP_0008421', 'lbl': 'Tall lumbar vertebral bodies', 'desc': 'label: Tall lumbar vertebral bodies\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008422', 'url': 'http://purl.obolibrary.org/obo/HP_0008422', 'lbl': 'Vertebral wedging', 'desc': 'label: Vertebral wedging\ndefinition : An abnormal shape of the vertebral bodies whereby the vertebral bodies are thick on one side and taper to a thin edge at the other.\nsynonyms :Wedge-shaped vertebrae; Wedged vertebrae; anterior wedging\n'}


{'id': 'HP_0008423', 'url': 'http://purl.obolibrary.org/obo/HP_0008423', 'lbl': 'Spinal dysplasia', 'desc': 'label: Spinal dysplasia\ndefinition : The presence of developmental dysplasia of the vertebral column.\nsynonyms :\n'}


{'id': 'HP_0008424', 'url': 'http://purl.obolibrary.org/obo/HP_0008424', 'lbl': 'Hypoplastic 5th lumbar vertebrae', 'desc': 'label: Hypoplastic 5th lumbar vertebrae\ndefinition : \nsynonyms :Underdeveloped 5th lumbar vertebrae\n'}


{'id': 'HP_0008425', 'url': 'http://purl.obolibrary.org/obo/HP_0008425', 'lbl': 'Cuboid-shaped thoracolumbar vertebral bodies', 'desc': 'label: Cuboid-shaped thoracolumbar vertebral bodies\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008428', 'url': 'http://purl.obolibrary.org/obo/HP_0008428', 'lbl': 'Vertebral clefting', 'desc': 'label: Vertebral clefting\ndefinition : Schisis (cleft or cleavage) of vertebral bodies.\nsynonyms :Vertebral clefts\n'}


{'id': 'HP_0008430', 'url': 'http://purl.obolibrary.org/obo/HP_0008430', 'lbl': 'Anterior beaking of lumbar vertebrae', 'desc': 'label: Anterior beaking of lumbar vertebrae\ndefinition : Anterior tongue-like protrusions of the vertebral bodies of the lumbar spine.\nsynonyms :Anterior tongue-like protrusion of lumbar vertebral bodies\n'}


{'id': 'HP_0008432', 'url': 'http://purl.obolibrary.org/obo/HP_0008432', 'lbl': 'Anterior wedging of L1', 'desc': 'label: Anterior wedging of L1\ndefinition : An abnormality of the shape of the lumbar vertebra L1 such that it is wedge-shaped (narrow towards the front).\nsynonyms :\n'}


{'id': 'HP_0008433', 'url': 'http://purl.obolibrary.org/obo/HP_0008433', 'lbl': 'Reversed usual vertebral column curves', 'desc': 'label: Reversed usual vertebral column curves\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008434', 'url': 'http://purl.obolibrary.org/obo/HP_0008434', 'lbl': 'Hypoplastic cervical vertebrae', 'desc': 'label: Hypoplastic cervical vertebrae\ndefinition : \nsynonyms :Cervical vertebrae hypoplasia; Underdeveloped cervical vertebrae\n'}


{'id': 'HP_0008435', 'url': 'http://purl.obolibrary.org/obo/HP_0008435', 'lbl': 'Absent in utero ossification of vertebral bodies', 'desc': 'label: Absent in utero ossification of vertebral bodies\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008436', 'url': 'http://purl.obolibrary.org/obo/HP_0008436', 'lbl': 'Absent/hypoplastic coccyx', 'desc': 'label: Absent/hypoplastic coccyx\ndefinition : \nsynonyms :Absent/small tailbone; Absent/underdeveloped tailbone\n'}


{'id': 'HP_0008437', 'url': 'http://purl.obolibrary.org/obo/HP_0008437', 'lbl': 'Bifid thoracic vertebrae', 'desc': 'label: Bifid thoracic vertebrae\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008438', 'url': 'http://purl.obolibrary.org/obo/HP_0008438', 'lbl': 'Vertebral arch anomaly', 'desc': 'label: Vertebral arch anomaly\ndefinition : A morphological abnormality of the vertebral arch, i.e., of the posterior part of a vertebra.\nsynonyms :Vertebral arch abnormalities\n'}


{'id': 'HP_0008439', 'url': 'http://purl.obolibrary.org/obo/HP_0008439', 'lbl': 'Lumbar hemivertebrae', 'desc': 'label: Lumbar hemivertebrae\ndefinition : Absence of one half of the vertebral body in the lumbar spine.\nsynonyms :\n'}


{'id': 'HP_0008440', 'url': 'http://purl.obolibrary.org/obo/HP_0008440', 'lbl': 'C1-C2 vertebral abnormality', 'desc': 'label: C1-C2 vertebral abnormality\ndefinition : Any abnormality of the atlas and the axis.\nsynonyms :\n'}


{'id': 'HP_0008441', 'url': 'http://purl.obolibrary.org/obo/HP_0008441', 'lbl': 'Herniation of intervertebral nuclei', 'desc': 'label: Herniation of intervertebral nuclei\ndefinition : The presence of one or more herniated nucleus pulposus of intervertebral disk.\nsynonyms :Herniated disc; Herniated disk; Herniated intervertebral nuclei\n'}


{'id': 'HP_0008442', 'url': 'http://purl.obolibrary.org/obo/HP_0008442', 'lbl': 'Vertebral hyperostosis', 'desc': 'label: Vertebral hyperostosis\ndefinition : Excessive growth of the bones of the vertebral bodies.\nsynonyms :\n'}


{'id': 'HP_0008443', 'url': 'http://purl.obolibrary.org/obo/HP_0008443', 'lbl': 'Neuropathic spinal arthropathy', 'desc': 'label: Neuropathic spinal arthropathy\ndefinition : A progressive disorder of vertebral joint degeneration that occurs in the setting of any condition characterized by decreased afferent innervation, involving loss of deep pain and proprioceptive sensation in the vertebral column. Patients most commonly present with symptoms of lower back pain, sitting imbalance, progressive spinal deformity (usually kyphosis), and an audible clicking sound on changing postures.\nsynonyms :Charcot spinal arthropathy; Spinal deformities; Spinal neuroarthropathy\n'}


{'id': 'HP_0008444', 'url': 'http://purl.obolibrary.org/obo/HP_0008444', 'lbl': 'Posterior wedging of vertebral bodies', 'desc': 'label: Posterior wedging of vertebral bodies\ndefinition : An abnormality of the shape of vertebrae, such that they are wedge-shaped (narrow towards the back).\nsynonyms :Posterior wedging\n'}


{'id': 'HP_0008445', 'url': 'http://purl.obolibrary.org/obo/HP_0008445', 'lbl': 'Cervical spinal canal stenosis', 'desc': 'label: Cervical spinal canal stenosis\ndefinition : An abnormal narrowing of the cervical spinal canal.\nsynonyms :Narrow cervical spinal canal\n'}


{'id': 'HP_0008447', 'url': 'http://purl.obolibrary.org/obo/HP_0008447', 'lbl': 'Hypoplastic coccygeal vertebrae', 'desc': 'label: Hypoplastic coccygeal vertebrae\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008449', 'url': 'http://purl.obolibrary.org/obo/HP_0008449', 'lbl': 'Progressive cervical vertebral spine fusion', 'desc': 'label: Progressive cervical vertebral spine fusion\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008450', 'url': 'http://purl.obolibrary.org/obo/HP_0008450', 'lbl': 'Narrow vertebral interpedicular distance', 'desc': 'label: Narrow vertebral interpedicular distance\ndefinition : A reduction of the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces.\nsynonyms :Interpedicular narrowing; Narrow interpedicular space; Narrow interpediculate distances; Narrowing of interpediculate distances\n'}


{'id': 'HP_0008451', 'url': 'http://purl.obolibrary.org/obo/HP_0008451', 'lbl': 'Posterior vertebral hypoplasia', 'desc': 'label: Posterior vertebral hypoplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008452', 'url': 'http://purl.obolibrary.org/obo/HP_0008452', 'lbl': 'Wafer-thin platyspondyly', 'desc': 'label: Wafer-thin platyspondyly\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008453', 'url': 'http://purl.obolibrary.org/obo/HP_0008453', 'lbl': 'Congenital kyphoscoliosis', 'desc': 'label: Congenital kyphoscoliosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008454', 'url': 'http://purl.obolibrary.org/obo/HP_0008454', 'lbl': 'Lumbar kyphosis', 'desc': 'label: Lumbar kyphosis\ndefinition : Over curvature of the lumbar region.\nsynonyms :Lumbar gibbus deformity; Rounded lower back\n'}


{'id': 'HP_0008455', 'url': 'http://purl.obolibrary.org/obo/HP_0008455', 'lbl': 'Dysplastic sacrum', 'desc': 'label: Dysplastic sacrum\ndefinition : A developmental defect of the sacrum characterized by partial or disordered development of the sacrum in which portions of the sacrum, which normally is formed by fusion of five sacral vertebrae S1-S5, fail to form or fail to form normally.\nsynonyms :Absence of some of the sacral and coccygeal bones; Partial sacral agenesis; Sacral dysgenesis\n'}


{'id': 'HP_0008456', 'url': 'http://purl.obolibrary.org/obo/HP_0008456', 'lbl': 'C2-C3 subluxation', 'desc': 'label: C2-C3 subluxation\ndefinition : A partial dislocation of the intervertebral joint between the second and third cervical vertebrae.\nsynonyms :\n'}


{'id': 'HP_0008457', 'url': 'http://purl.obolibrary.org/obo/HP_0008457', 'lbl': 'Caudal interpedicular narrowing', 'desc': 'label: Caudal interpedicular narrowing\ndefinition : Narrowing (becoming gradually narrower) of the distance between vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column. Note that normally, the interpedicular distances get progressively wider as one proceeds down the spine.\nsynonyms :Caudal narrowing of interpedicular distances\n'}


{'id': 'HP_0008458', 'url': 'http://purl.obolibrary.org/obo/HP_0008458', 'lbl': 'Progressive congenital scoliosis', 'desc': 'label: Progressive congenital scoliosis\ndefinition : A progressive form of scoliosis with congenital onset.\nsynonyms :\n'}


{'id': 'HP_0008459', 'url': 'http://purl.obolibrary.org/obo/HP_0008459', 'lbl': 'Cervical vertebral agenesis', 'desc': 'label: Cervical vertebral agenesis\ndefinition : Agenesis of one or more vertebrae of the cervical vertebral column.\nsynonyms :Cervical vertebrae agenesis; Missing cervical vertebrae\n'}


{'id': 'HP_0008460', 'url': 'http://purl.obolibrary.org/obo/HP_0008460', 'lbl': 'Hypoplastic spinal processes', 'desc': 'label: Hypoplastic spinal processes\ndefinition : \nsynonyms :Underdeveloped spinal processes\n'}


{'id': 'HP_0008461', 'url': 'http://purl.obolibrary.org/obo/HP_0008461', 'lbl': 'Cervical vertebral facet hypoplasia', 'desc': 'label: Cervical vertebral facet hypoplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008462', 'url': 'http://purl.obolibrary.org/obo/HP_0008462', 'lbl': 'Cervical instability', 'desc': 'label: Cervical instability\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008463', 'url': 'http://purl.obolibrary.org/obo/HP_0008463', 'lbl': 'Central vertebral hypoplasia', 'desc': 'label: Central vertebral hypoplasia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008464', 'url': 'http://purl.obolibrary.org/obo/HP_0008464', 'lbl': 'Absent spinous processes of lower thoracic and lumbar vertebrae', 'desc': 'label: Absent spinous processes of lower thoracic and lumbar vertebrae\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008465', 'url': 'http://purl.obolibrary.org/obo/HP_0008465', 'lbl': 'Absent vertebra', 'desc': 'label: Absent vertebra\ndefinition : A developmental defect characterized by agenesis of one or more vertebral bodies.\nsynonyms :Absent vertebrae\n'}


{'id': 'HP_0008467', 'url': 'http://purl.obolibrary.org/obo/HP_0008467', 'lbl': 'Thoracic hemivertebrae', 'desc': 'label: Thoracic hemivertebrae\ndefinition : Absence of one half of the vertebral body in the thoracic spine.\nsynonyms :Midthoracic hemivertebrae\n'}


{'id': 'HP_0008468', 'url': 'http://purl.obolibrary.org/obo/HP_0008468', 'lbl': 'Abnormal sacral segmentation', 'desc': 'label: Abnormal sacral segmentation\ndefinition : An abnormality related to a defect of vertebral separation of sacral vertebrae during development.\nsynonyms :\n'}


{'id': 'HP_0008469', 'url': 'http://purl.obolibrary.org/obo/HP_0008469', 'lbl': 'Cervical vertebral dysplasia', 'desc': 'label: Cervical vertebral dysplasia\ndefinition : Dysplasia of the cervical vertebral column.\nsynonyms :\n'}


{'id': 'HP_0008470', 'url': 'http://purl.obolibrary.org/obo/HP_0008470', 'lbl': 'Lower thoracic interpediculate narrowness', 'desc': 'label: Lower thoracic interpediculate narrowness\ndefinition : A reduction of the distance between the lower thoracic vertebral pedicles.\nsynonyms :Narrowness of interpediculate distances in lower thoracic regions\n'}


{'id': 'HP_0008472', 'url': 'http://purl.obolibrary.org/obo/HP_0008472', 'lbl': 'Prominent protruding coccyx', 'desc': 'label: Prominent protruding coccyx\ndefinition : \nsynonyms :Large tailbone; Prominent protruding tailbone\n'}


{'id': 'HP_0008473', 'url': 'http://purl.obolibrary.org/obo/HP_0008473', 'lbl': 'Narrow anterio-posterior vertebral body diameter', 'desc': 'label: Narrow anterio-posterior vertebral body diameter\ndefinition : An abnormal reduction of the anterioposterior diameter of the vertebral body.\nsynonyms :Reduced anterior-posterior diameter of vertebral bodies; Reduced sagittal diameter of vertebrae\n'}


{'id': 'HP_0008475', 'url': 'http://purl.obolibrary.org/obo/HP_0008475', 'lbl': 'Hypoplastic sacral vertebrae', 'desc': 'label: Hypoplastic sacral vertebrae\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008476', 'url': 'http://purl.obolibrary.org/obo/HP_0008476', 'lbl': 'Irregular sclerotic endplates', 'desc': 'label: Irregular sclerotic endplates\ndefinition : \nsynonyms :irregular, dense end plate\n'}


{'id': 'HP_0008477', 'url': 'http://purl.obolibrary.org/obo/HP_0008477', 'lbl': 'Poorly ossified cervical vertebrae', 'desc': 'label: Poorly ossified cervical vertebrae\ndefinition : Decreased ossification of the cervical vertebral bodies, i.e., of the Cervical vertebrae set.\nsynonyms :\n'}


{'id': 'HP_0008478', 'url': 'http://purl.obolibrary.org/obo/HP_0008478', 'lbl': 'Scheuermann-like vertebral changes', 'desc': 'label: Scheuermann-like vertebral changes\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008479', 'url': 'http://purl.obolibrary.org/obo/HP_0008479', 'lbl': 'Hypoplastic vertebral bodies', 'desc': 'label: Hypoplastic vertebral bodies\ndefinition : \nsynonyms :Small vertebrae; Small vertebral bodies; Underdeveloped back bones\n'}


{'id': 'HP_0008480', 'url': 'http://purl.obolibrary.org/obo/HP_0008480', 'lbl': 'Cervical spondylosis', 'desc': 'label: Cervical spondylosis\ndefinition : The presence of arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column.\nsynonyms :Cervical osteoarthritis; Cervical spine degeneration; Neck arthritis\n'}


{'id': 'HP_0008482', 'url': 'http://purl.obolibrary.org/obo/HP_0008482', 'lbl': 'Asymmetry of spinal facet joints', 'desc': 'label: Asymmetry of spinal facet joints\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008483', 'url': 'http://purl.obolibrary.org/obo/HP_0008483', 'lbl': 'Cervical vertebral bodies with decreased anteroposterior diameter', 'desc': 'label: Cervical vertebral bodies with decreased anteroposterior diameter\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0008484', 'url': 'http://purl.obolibrary.org/obo/HP_0008484', 'lbl': 'Thoracolumbar interpediculate narrowness', 'desc': 'label: Thoracolumbar interpediculate narrowness\ndefinition : A reduction of the distance between thoracolumbar vertebral pedicles.\nsynonyms :Narrow thoracolumbar interpediculate distance\n'}


{'id': 'HP_0008486', 'url': 'http://purl.obolibrary.org/obo/HP_0008486', 'lbl': 'Lumbar interpedicular narrowing', 'desc': 'label: Lumbar interpedicular narrowing\ndefinition : Narrowing (becoming gradually narrower) of the distance between lumbar vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column.\nsynonyms :Decreasing lumbar vertebrae interpediculate distance\n'}