{'id': 'HP_0020121', 'url': 'http://purl.obolibrary.org/obo/HP_0020121', 'lbl': 'Conception by assisted reproductive technology', 'desc': 'label: Conception by assisted reproductive technology\ndefinition : A history of conception by an assisted reproductive technology such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and cryopreservation.\nsynonyms :\n'}


{'id': 'HP_0020122', 'url': 'http://purl.obolibrary.org/obo/HP_0020122', 'lbl': 'Bite cells', 'desc': 'label: Bite cells\ndefinition : Red blood cells that appear to have parts of them bitten away.\nsynonyms :Blister cells; Degmacytes\n'}


{'id': 'HP_0020123', 'url': 'http://purl.obolibrary.org/obo/HP_0020123', 'lbl': 'Tympanosclerosis', 'desc': 'label: Tympanosclerosis\ndefinition : A stiffening of the tympanic membrane due to calcification, typically presents as white plaque-like lesions, involving discrete regions of the tympanic membrane and/or middle ear.\nsynonyms :Tympanic calcification\n'}


{'id': 'HP_0020125', 'url': 'http://purl.obolibrary.org/obo/HP_0020125', 'lbl': 'Spontaneous conjunctival filtering bleb', 'desc': 'label: Spontaneous conjunctival filtering bleb\ndefinition : Avascular cystic elevations of the superior conjunctiva not related to ocular surgery or trauma.\nsynonyms :Conjunctival avascular cysts (filtering blebs); Spontaneous filtering bleb\n'}


{'id': 'HP_0020126', 'url': 'http://purl.obolibrary.org/obo/HP_0020126', 'lbl': 'Prostate mass', 'desc': 'label: Prostate mass\ndefinition : A lump detected in the prostate. In this context, mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction.\nsynonyms :\n'}


{'id': 'HP_0020127', 'url': 'http://purl.obolibrary.org/obo/HP_0020127', 'lbl': 'Periarticular soft-tissue mass', 'desc': 'label: Periarticular soft-tissue mass\ndefinition : A lump detected in the region that surrounds a joint. In this context, mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction.\nsynonyms :\n'}


{'id': 'HP_0020128', 'url': 'http://purl.obolibrary.org/obo/HP_0020128', 'lbl': 'Aplasia of the olfactory tract', 'desc': 'label: Aplasia of the olfactory tract\ndefinition : Aplasia (congenital absence) of the olfactory tract, which causes anosmia, a complete loss of the sense of smell.\nsynonyms :\n'}


{'id': 'HP_0020129', 'url': 'http://purl.obolibrary.org/obo/HP_0020129', 'lbl': 'Abnormal urine protein level', 'desc': 'label: Abnormal urine protein level\ndefinition : Any deviation of the concentration of one or more proteins in the urine.\nsynonyms :\n'}


{'id': 'HP_0020130', 'url': 'http://purl.obolibrary.org/obo/HP_0020130', 'lbl': 'Increased urinary neutrophil gelatinase-associated lipocalin', 'desc': 'label: Increased urinary neutrophil gelatinase-associated lipocalin\ndefinition : An increased concentration of neutrophil gelatinase-associated lipocalin in the urine (there is no generally accepted threshold, but some studies choose a threshold of above 150 nanogram per milliliter).\nsynonyms :Increased urinary NGAL\n'}


{'id': 'HP_0020131', 'url': 'http://purl.obolibrary.org/obo/HP_0020131', 'lbl': 'Abnormal tubular basement membrane morphology', 'desc': 'label: Abnormal tubular basement membrane morphology\ndefinition : Abnormal structure of the basement membrane of the renal tubulus.\nsynonyms :\n'}


{'id': 'HP_0020132', 'url': 'http://purl.obolibrary.org/obo/HP_0020132', 'lbl': 'Thickening of the tubular basement membrane', 'desc': 'label: Thickening of the tubular basement membrane\ndefinition : Increase in thickness of the basement membrane of the tubulus of the kidney.\nsynonyms :\n'}


{'id': 'HP_0020133', 'url': 'http://purl.obolibrary.org/obo/HP_0020133', 'lbl': 'Podocyte hypertrophy', 'desc': 'label: Podocyte hypertrophy\ndefinition : Increased visceral epithelial cell size, with or without cytoplasmic protein droplets.\nsynonyms :Glomerular visceral epithelial cell hypertrophy; Hypertrophy of visceral epithelial cells\n'}


{'id': 'HP_0020134', 'url': 'http://purl.obolibrary.org/obo/HP_0020134', 'lbl': 'Increased urine neutrophil count', 'desc': 'label: Increased urine neutrophil count\ndefinition : Abnormally increased count of neutrophils in urine.\nsynonyms :\n'}


{'id': 'HP_0020135', 'url': 'http://purl.obolibrary.org/obo/HP_0020135', 'lbl': 'Myofibromatosis', 'desc': 'label: Myofibromatosis\ndefinition : A mesenchymal neoplasm characterized by solitary or multiple nodules involving the skin, striated muscles, bones and, sometimes, viscera. It usually appears as a subcutaneous nodule, but can also appear as an ulcer, pedunculated lesion, or similar to a hemangioma. Histology shows well-circumscribed tapered cell lobes, resembling smooth muscle cells. At its center, perivascular round cells (hemangiopericitoides) are usually observed, giving a biphasic appearance.\nsynonyms :\n'}


{'id': 'HP_0020136', 'url': 'http://purl.obolibrary.org/obo/HP_0020136', 'lbl': 'Anticardiolipin IgG antibody positivity', 'desc': 'label: Anticardiolipin IgG antibody positivity\ndefinition : The presence of circulating IgG autoantibodies to cardiolipin.\nsynonyms :\n'}


{'id': 'HP_0020137', 'url': 'http://purl.obolibrary.org/obo/HP_0020137', 'lbl': 'Anticardiolipin IgM antibody positivity', 'desc': 'label: Anticardiolipin IgM antibody positivity\ndefinition : The presence of circulating IgM autoantibodies to cardiolipin.\nsynonyms :\n'}


{'id': 'HP_0020138', 'url': 'http://purl.obolibrary.org/obo/HP_0020138', 'lbl': 'History of recent animal bite', 'desc': 'label: History of recent animal bite\ndefinition : Medical history of a recent bite injury due to an animal.\nsynonyms :\n'}


{'id': 'HP_0020139', 'url': 'http://purl.obolibrary.org/obo/HP_0020139', 'lbl': 'History of recent insect bite', 'desc': 'label: History of recent insect bite\ndefinition : Medical history of a recent bite injury due to an insect.\nsynonyms :\n'}


{'id': 'HP_0020140', 'url': 'http://purl.obolibrary.org/obo/HP_0020140', 'lbl': 'History of recent tick bite', 'desc': 'label: History of recent tick bite\ndefinition : Medical history of a recent bite injury due to a tick.\nsynonyms :\n'}


{'id': 'HP_0020141', 'url': 'http://purl.obolibrary.org/obo/HP_0020141', 'lbl': 'Blood pressure substantially higher in legs than arms', 'desc': 'label: Blood pressure substantially higher in legs than arms\ndefinition : An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the legs being much higher than the blood pressure measure in the arms. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm.\nsynonyms :Blood pressure substantially higher in lower than upper extremities; Blood pressure substantially lower in arms than legs; Blood pressure substantially lower in upper than lower extremities\n'}


{'id': 'HP_0020142', 'url': 'http://purl.obolibrary.org/obo/HP_0020142', 'lbl': 'Blood pressure substantially higher in arms than legs', 'desc': 'label: Blood pressure substantially higher in arms than legs\ndefinition : An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the arms being much higher than the blood pressure measure in the legs. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm.\nsynonyms :Blood pressure substantially higher in upper than lower extremities; Increased arm-leg blood pressure gradient\n'}


{'id': 'HP_0020143', 'url': 'http://purl.obolibrary.org/obo/HP_0020143', 'lbl': 'Tracheal duplication cyst', 'desc': 'label: Tracheal duplication cyst\ndefinition : A cyst in the trachea, whose wall is made up by tissue similar to the bronchial tree, including cartilage and smooth muscle, and is lined by secretory respiratory epithelium composed of cuboid or columnar ciliated epithelium.\nsynonyms :\n'}


{'id': 'HP_0020144', 'url': 'http://purl.obolibrary.org/obo/HP_0020144', 'lbl': 'Calcium phosphate crystalluria', 'desc': 'label: Calcium phosphate crystalluria\ndefinition : The presence of calcium phosphate crystals in the urine.\nsynonyms :\n'}


{'id': 'HP_0020145', 'url': 'http://purl.obolibrary.org/obo/HP_0020145', 'lbl': 'Calcium oxalate crystalluria', 'desc': 'label: Calcium oxalate crystalluria\ndefinition : The presence of calcium oxalate crystals in the urine.\nsynonyms :\n'}


{'id': 'HP_0020146', 'url': 'http://purl.obolibrary.org/obo/HP_0020146', 'lbl': 'Calcium carbonate crystalluria', 'desc': 'label: Calcium carbonate crystalluria\ndefinition : The presence of calcium carbonate crystals in the urine.\nsynonyms :\n'}


{'id': 'HP_0020147', 'url': 'http://purl.obolibrary.org/obo/HP_0020147', 'lbl': '2-Methylbutyryl glycinuria', 'desc': 'label: 2-Methylbutyryl glycinuria\ndefinition : Increased concentration of 2-methylbutyryl glycine in the urine.\nsynonyms :\n'}


{'id': 'HP_0020148', 'url': 'http://purl.obolibrary.org/obo/HP_0020148', 'lbl': 'Increased circulating mead acid level', 'desc': 'label: Increased circulating mead acid level\ndefinition : An abnormally elevated concentration od mead acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0020149', 'url': 'http://purl.obolibrary.org/obo/HP_0020149', 'lbl': 'Elevated circulating succinate', 'desc': 'label: Elevated circulating succinate\ndefinition : An increase concentration of succinate in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0020150', 'url': 'http://purl.obolibrary.org/obo/HP_0020150', 'lbl': 'Elevated urinary uromodulin', 'desc': 'label: Elevated urinary uromodulin\ndefinition : An increased amount of uromodulin (also known as Tamm Horsfall protein) in the urine.\nsynonyms :Elevated urinary Tamm-Horsfall protein concentration\n'}


{'id': 'HP_0020151', 'url': 'http://purl.obolibrary.org/obo/HP_0020151', 'lbl': 'Anti-dsDNA antibody positivity', 'desc': 'label: Anti-dsDNA antibody positivity\ndefinition : The presence of autoantibodies (immunoglobulins) in the serum that react against double-stranded DNA.\nsynonyms :\n'}


{'id': 'HP_0020152', 'url': 'http://purl.obolibrary.org/obo/HP_0020152', 'lbl': 'Distal joint laxity', 'desc': 'label: Distal joint laxity\ndefinition : Lack of stability of a distal joint (e.g., finger).\nsynonyms :\n'}


{'id': 'HP_0020153', 'url': 'http://purl.obolibrary.org/obo/HP_0020153', 'lbl': 'Positive blood 1,3 beta glucan test', 'desc': 'label: Positive blood 1,3 beta glucan test\ndefinition : Beta-1,3-glucan is a major constituent of all of the characterized fungal cell walls, making up between 30-80 percent of the mass of the wall. It is a biomarker of fungal infections such as invasive pulmonary aspergillosis.\nsynonyms :\n'}


{'id': 'HP_0020154', 'url': 'http://purl.obolibrary.org/obo/HP_0020154', 'lbl': 'Nevus comedonicus', 'desc': 'label: Nevus comedonicus\ndefinition : A type of epidermal nevus characterized by closely arranged, dilated follicular openings with keratinous plugs resembling classical comedones.\nsynonyms :\n'}


{'id': 'HP_0020155', 'url': 'http://purl.obolibrary.org/obo/HP_0020155', 'lbl': 'Abnormal oocyte morphology', 'desc': 'label: Abnormal oocyte morphology\ndefinition : An abnormal structure of the female germ cell (egg cell).\nsynonyms :\n'}


{'id': 'HP_0020156', 'url': 'http://purl.obolibrary.org/obo/HP_0020156', 'lbl': 'Abnormal zona pellucida morphology', 'desc': 'label: Abnormal zona pellucida morphology\ndefinition : Abnormal structure of the oocyte extracellular matrix region known as teh zona pellucida.\nsynonyms :\n'}


{'id': 'HP_0020157', 'url': 'http://purl.obolibrary.org/obo/HP_0020157', 'lbl': 'Thin zona pellucida', 'desc': 'label: Thin zona pellucida\ndefinition : Reduced thickness of the zona pellucida.\nsynonyms :\n'}


{'id': 'HP_0020158', 'url': 'http://purl.obolibrary.org/obo/HP_0020158', 'lbl': 'Increased circulating adrenic acid concentration', 'desc': 'label: Increased circulating adrenic acid concentration\ndefinition : An increased concentration of adrenic acid (also known as cis-7,10,13,16-Docosatetraenoic acid) in the blood circulation.\nsynonyms :Increased circulating docosatetraenoate level\n'}


{'id': 'HP_0020159', 'url': 'http://purl.obolibrary.org/obo/HP_0020159', 'lbl': 'Reduced response to gonadotropin-releasing hormone stimulation test', 'desc': 'label: Reduced response to gonadotropin-releasing hormone stimulation test\ndefinition : Failure of the gonadotropin-releasing hormone (GnRH) stimulation test to induce an appropriate increased in luteinizing hormone (LH), follicle-stimulating hormone (FSH) levels.\nsynonyms :Reduce response to GnRH stimulation test\n'}


{'id': 'HP_0020160', 'url': 'http://purl.obolibrary.org/obo/HP_0020160', 'lbl': 'GM1-ganglioside accumulation', 'desc': 'label: GM1-ganglioside accumulation\ndefinition : Cellular accumulation of GM1 gangliosides.\nsynonyms :\n'}


{'id': 'HP_0020161', 'url': 'http://purl.obolibrary.org/obo/HP_0020161', 'lbl': 'Branch retinal artery occlusion', 'desc': 'label: Branch retinal artery occlusion\ndefinition : Blockage of a branch of the retinal artery. This can cause loss of a section of visual field.\nsynonyms :\n'}


{'id': 'HP_0020163', 'url': 'http://purl.obolibrary.org/obo/HP_0020163', 'lbl': 'Cilioretinal artery occlusion', 'desc': 'label: Cilioretinal artery occlusion\ndefinition : Blockage of the cilioretinal artery. The central retinal artery supplies the inner retina and the surface of the optic nerve. In some individuals, the cilioretinal artery, a branch of the ciliary circulation, may supply a portion of the retina including the macula. In cilioretinal artery occlusion, vision loss results from cell death in the inner retinal layers (mainly ganglion cells) despite relative sparing of the outer layers.\nsynonyms :\n'}


{'id': 'HP_0020164', 'url': 'http://purl.obolibrary.org/obo/HP_0020164', 'lbl': 'Ophthalmic artery occlusion', 'desc': 'label: Ophthalmic artery occlusion\ndefinition : A partial or complete obstruction of the ophthalmic artery (branch of the internal carotid artery) that may lead to severe ischemia of the affected globe and associated ocular tissues. It can present with a similar picture to central retinal artery occlusion; however, profound choroidal ischaemia also occurs.\nsynonyms :\n'}


{'id': 'HP_0020165', 'url': 'http://purl.obolibrary.org/obo/HP_0020165', 'lbl': 'Branch retinal vein occlusion', 'desc': 'label: Branch retinal vein occlusion\ndefinition : Blockage of a branch of the retinal vein. It may present with sudden-onset of painless vision loss or visual field defect correlating to the area of perfusion of the obstructed vessels.\nsynonyms :\n'}


{'id': 'HP_0020166', 'url': 'http://purl.obolibrary.org/obo/HP_0020166', 'lbl': 'Central retinal vein occlusion', 'desc': 'label: Central retinal vein occlusion\ndefinition : Central retinal vein occlusion is an occlusion of the main retinal vein posterior to the lamina cribrosa of the optic nerve and is typically caused by thrombosis.\nsynonyms :\n'}


{'id': 'HP_0020167', 'url': 'http://purl.obolibrary.org/obo/HP_0020167', 'lbl': 'Hemiretinal vein occlusion', 'desc': 'label: Hemiretinal vein occlusion\ndefinition : A variant of central retinal vein occlusions that involves the superior or inferior half of the retina.\nsynonyms :\n'}


{'id': 'HP_0020169', 'url': 'http://purl.obolibrary.org/obo/HP_0020169', 'lbl': 'Abnormal drug response', 'desc': 'label: Abnormal drug response\ndefinition : An anomalous response to a medication related to individual variation in metabolic or immune response to drugs varying from potentially from potentially life-threatening adverse drug reactions to alteration of therapeutic efficacy.\nsynonyms :\n'}


{'id': 'HP_0020170', 'url': 'http://purl.obolibrary.org/obo/HP_0020170', 'lbl': 'Increased blood drug concentration', 'desc': 'label: Increased blood drug concentration\ndefinition : High plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime.\nsynonyms :Elevated blood drug concentration; Elevated plasma drug concentration; Elevated serum drug concentrations; Increased plasma drug concentration; Increased serum drug concentration\n'}


{'id': 'HP_0020171', 'url': 'http://purl.obolibrary.org/obo/HP_0020171', 'lbl': 'Decreased blood drug concentration', 'desc': 'label: Decreased blood drug concentration\ndefinition : Low plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime.\nsynonyms :Decreased plasma drug concentration; Decreased serum drug concentration; Reduced blood drug concentration; Reduced plasma drug concentration; Reduced serum drug concentrations\n'}


{'id': 'HP_0020172', 'url': 'http://purl.obolibrary.org/obo/HP_0020172', 'lbl': 'Adverse drug response', 'desc': 'label: Adverse drug response\ndefinition : An unpleasant or harmful reaction resulting from treatment with a drug.\nsynonyms :Adverse drug reaction; Drug-induced reaction; Drug-induced response; Toxic drug response\n'}


{'id': 'HP_0020173', 'url': 'http://purl.obolibrary.org/obo/HP_0020173', 'lbl': 'Reduced drug efficacy', 'desc': 'label: Reduced drug efficacy\ndefinition : Decreased response to a drug intervention in comparison to the expected response.\nsynonyms :Decreased drug efficacy\n'}


{'id': 'HP_0020174', 'url': 'http://purl.obolibrary.org/obo/HP_0020174', 'lbl': 'Refractory drug response', 'desc': 'label: Refractory drug response\ndefinition : Absent or significantly reduced efficacy of drug intervention characterized by lack of measurable benefit or deterioration of disease course.\nsynonyms :Drug resistance\n'}


{'id': 'HP_0020175', 'url': 'http://purl.obolibrary.org/obo/HP_0020175', 'lbl': 'Reduced cholinesterase level', 'desc': 'label: Reduced cholinesterase level\ndefinition : A decreased amount of cholinesterase in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0020176', 'url': 'http://purl.obolibrary.org/obo/HP_0020176', 'lbl': 'Cholesterol crystalluria', 'desc': 'label: Cholesterol crystalluria\ndefinition : The presence of cholesterol crystals in the urine.\nsynonyms :\n'}


{'id': 'HP_0020177', 'url': 'http://purl.obolibrary.org/obo/HP_0020177', 'lbl': 'Abnormal proportion of CD8-positive, alpha-beta TEMRA T cells', 'desc': 'label: Abnormal proportion of CD8-positive, alpha-beta TEMRA T cells\ndefinition : An abnormal proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.\nsynonyms :Abnormal proportion of effector memory CD8-positive, alpha-beta T cells, terminally differentiated\n'}


{'id': 'HP_0020178', 'url': 'http://purl.obolibrary.org/obo/HP_0020178', 'lbl': 'Abnormal dendritic cell count', 'desc': 'label: Abnormal dendritic cell count\ndefinition : A deviation from the normal count of dendritic cells in the peripheral blood circulation. Dendritic cells are of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).\nsynonyms :\n'}


{'id': 'HP_0020179', 'url': 'http://purl.obolibrary.org/obo/HP_0020179', 'lbl': 'Abnormal circulating haptoglobin concentration', 'desc': 'label: Abnormal circulating haptoglobin concentration\ndefinition : A deviation from the normal concentration of haptoglobin in the blood circulation.\nsynonyms :Abnormal haptoglobin level\n'}


{'id': 'HP_0020180', 'url': 'http://purl.obolibrary.org/obo/HP_0020180', 'lbl': 'Elevated haptoglobin level', 'desc': 'label: Elevated haptoglobin level\ndefinition : An abnormally high concentration of haptoglobin in the blood circulation. Haptoglobin is an acute-phase reactant whose levels can become elevated in the presence of infection and inflammation.\nsynonyms :\n'}


{'id': 'HP_0020181', 'url': 'http://purl.obolibrary.org/obo/HP_0020181', 'lbl': 'Reduced haptoglobin level', 'desc': 'label: Reduced haptoglobin level\ndefinition : An abnormally low concentration of haptoglobin in the blood circulation. Decreased haptoglobin in conjunction with increased reticulocyte count and anemia may indicate hemolysis. Decreased haptoglobin levels can also occur in the absence of hemolysis, due to cirrhosis of the liver, disseminated ovarian carcinomatosis, pulmonary sarcoidosis, and elevated estrogen state.\nsynonyms :\n'}


{'id': 'HP_0020182', 'url': 'http://purl.obolibrary.org/obo/HP_0020182', 'lbl': 'Abnormal circulating A-type atrial natriuretic peptide concentration', 'desc': 'label: Abnormal circulating A-type atrial natriuretic peptide concentration\ndefinition : A measurable change in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.\nsynonyms :Abnormal A-type atrial natriuretic peptide level\n'}


{'id': 'HP_0020183', 'url': 'http://purl.obolibrary.org/obo/HP_0020183', 'lbl': 'Increased circulating A-type natriuretic peptide concentration', 'desc': 'label: Increased circulating A-type natriuretic peptide concentration\ndefinition : A measurable elevation in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.\nsynonyms :Increased circulating A-type natriuretic peptide level\n'}


{'id': 'HP_0020184', 'url': 'http://purl.obolibrary.org/obo/HP_0020184', 'lbl': 'Decreased circulating A-type natriuretic peptide concentration', 'desc': 'label: Decreased circulating A-type natriuretic peptide concentration\ndefinition : A measurable reduction in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.\nsynonyms :Decreased circulating A-type natriuretic peptide level\n'}


{'id': 'HP_0020185', 'url': 'http://purl.obolibrary.org/obo/HP_0020185', 'lbl': 'Superior cerebellar dysplasia', 'desc': 'label: Superior cerebellar dysplasia\ndefinition : Abnormal morphological development of the superior part of the cerebellum.\nsynonyms :\n'}


{'id': 'HP_0020186', 'url': 'http://purl.obolibrary.org/obo/HP_0020186', 'lbl': 'Multilobulated spleen', 'desc': 'label: Multilobulated spleen\ndefinition : The fetal spleen is lobulated, and these lobules normally disappear before the birth. Lobulation of the spleen may persist into adult life and be typically seen along the medial part of the spleen. A persisting lobule results in a variation in shape of the spleen.\nsynonyms :Multi-lobulated spleen\n'}


{'id': 'HP_0020187', 'url': 'http://purl.obolibrary.org/obo/HP_0020187', 'lbl': 'Thick pachygyria', 'desc': 'label: Thick pachygyria\ndefinition : Pachygyria with a very thick cerebral cortex measuring 10-20 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age.\nsynonyms :Pachygyria with cortical thickness > 10 mm; Pachygyria with cortical thickness above 10 mm\n'}


{'id': 'HP_0020188', 'url': 'http://purl.obolibrary.org/obo/HP_0020188', 'lbl': 'Anterior predominant pachygyria with 5-10 mm cortical thickness', 'desc': 'label: Anterior predominant pachygyria with 5-10 mm cortical thickness\ndefinition : Pachygyria with cortical thickness between 5 and 10 mm with and a posterior predominant severety gradient. The severety gradient is determined based on the gyral width, with gyri typically over 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.\nsynonyms :\n'}


{'id': 'HP_0020189', 'url': 'http://purl.obolibrary.org/obo/HP_0020189', 'lbl': 'Posterior predominant thick cortex pachygyria', 'desc': 'label: Posterior predominant thick cortex pachygyria\ndefinition : Pachygyria with cortical thickness above 10 mm with and a posterior predominant severety gradient. The severety gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.\nsynonyms :Occipital predomimant classic pachygyria; Pachygyria with cortical thickness over 10 mm posterior predominant\n'}


{'id': 'HP_0020190', 'url': 'http://purl.obolibrary.org/obo/HP_0020190', 'lbl': 'Perisylvian predominant thick cortex pachygyria', 'desc': 'label: Perisylvian predominant thick cortex pachygyria\ndefinition : Pachygyria with cortical thickness greater than 10 mm and a perisylvian predominant severity gradient. The severity gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Perisylvian predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.\nsynonyms :Pachygyria with cortical thickness > 10 mm perisylvian predominant\n'}


{'id': 'HP_0020191', 'url': 'http://purl.obolibrary.org/obo/HP_0020191', 'lbl': 'Anterior predominant thick cortex pachygyria', 'desc': 'label: Anterior predominant thick cortex pachygyria\ndefinition : Pachygyria with cortical thickness greater than 10 mm and an anterior predominant severity gradient. The severety gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Anterior predominant gradient indicates pachygyria more severe over the frontal and temporal lobes.\nsynonyms :Pachygyria with cortical thickness > 10 mm anterior predominant\n'}


{'id': 'HP_0020192', 'url': 'http://purl.obolibrary.org/obo/HP_0020192', 'lbl': 'Pachygyria with 5-10 mm cortical thickness', 'desc': 'label: Pachygyria with 5-10 mm cortical thickness\ndefinition : Pachygyria with a mildly thickend cerebral cortex measuring 5-10 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age.\nsynonyms :\n'}


{'id': 'HP_0020193', 'url': 'http://purl.obolibrary.org/obo/HP_0020193', 'lbl': 'Prolonged reptilase time', 'desc': 'label: Prolonged reptilase time\ndefinition : An abnormally increased duration of the reptilase time. Reptilase time is a functional plasma clotting assay, which is based on the enzymatic activity of batroxobin. By specifically cleaving fibrinogen A from fibrinogen, batroxobin leads to the formation of a stable fibrin clot. The time, starting from the addition of batroxobin to the plasma sample, until clot formation is the reptilase time and is given in seconds.\nsynonyms :\n'}


{'id': 'HP_0020194', 'url': 'http://purl.obolibrary.org/obo/HP_0020194', 'lbl': 'IgA heavy chain paraproteinemia', 'desc': 'label: IgA heavy chain paraproteinemia\ndefinition : An abnormal IgA heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.\nsynonyms :Alpha heavy chain disease\n'}


{'id': 'HP_0020195', 'url': 'http://purl.obolibrary.org/obo/HP_0020195', 'lbl': 'IgG heavy chain paraproteinemia', 'desc': 'label: IgG heavy chain paraproteinemia\ndefinition : An abnormal IgG heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.\nsynonyms :Gamma heavy-chain disease\n'}


{'id': 'HP_0020196', 'url': 'http://purl.obolibrary.org/obo/HP_0020196', 'lbl': 'IgM heavy chain paraproteinemia', 'desc': 'label: IgM heavy chain paraproteinemia\ndefinition : An abnormal IgM heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.\nsynonyms :\n'}


{'id': 'HP_0020197', 'url': 'http://purl.obolibrary.org/obo/HP_0020197', 'lbl': 'Increased circulating arachidonic acid concentration', 'desc': 'label: Increased circulating arachidonic acid concentration\ndefinition : An increased circulation of arachidonic acid in the blood circulation.\nsynonyms :Increased circulating arachidonate level; Increased circulating arachidonic acid level\n'}


{'id': 'HP_0020198', 'url': 'http://purl.obolibrary.org/obo/HP_0020198', 'lbl': 'Abnormal circulating 18-hydroxycorticosterone level', 'desc': 'label: Abnormal circulating 18-hydroxycorticosterone level\ndefinition : Any deviation from the normal concentration of 18-Hydroxycorticosterone level in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0020199', 'url': 'http://purl.obolibrary.org/obo/HP_0020199', 'lbl': 'Decreased circulating 18-hydroxycortisone level', 'desc': 'label: Decreased circulating 18-hydroxycortisone level\ndefinition : A subnormal concentration of 18-Hydroxycorticosterone level in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0020200', 'url': 'http://purl.obolibrary.org/obo/HP_0020200', 'lbl': 'Increased circulating 18-hydroxycortisone level', 'desc': 'label: Increased circulating 18-hydroxycortisone level\ndefinition : An abnormally elevated concentration of 18-Hydroxycorticosterone level in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0020201', 'url': 'http://purl.obolibrary.org/obo/HP_0020201', 'lbl': 'Abnormal sarcomere morphology', 'desc': 'label: Abnormal sarcomere morphology\ndefinition : Any structural anomaly of the sarcomere, which is unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.\nsynonyms :\n'}


{'id': 'HP_0020202', 'url': 'http://purl.obolibrary.org/obo/HP_0020202', 'lbl': 'Abnormal Z disc morphology', 'desc': 'label: Abnormal Z disc morphology\ndefinition : Any structural anomaly of the Z disc, which is the platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.\nsynonyms :\n'}


{'id': 'HP_0020203', 'url': 'http://purl.obolibrary.org/obo/HP_0020203', 'lbl': 'Z-band streaming', 'desc': 'label: Z-band streaming\ndefinition : Streaming or smearing of the Z band, which is then no longer confined to a narrow zone which bisects the I band. The Z disc may extend across the I band or the entire sarcomere in a zigzag manner. Focal thickening, smudging, and blurring of the Z band takes place concurrently. Myofibrillar disorganization is a frequent but not invariable accompanying change.\nsynonyms :\n'}


{'id': 'HP_0020204', 'url': 'http://purl.obolibrary.org/obo/HP_0020204', 'lbl': 'Tubulointerstitial bacterial infiltration', 'desc': 'label: Tubulointerstitial bacterial infiltration\ndefinition : Tubulointerstitial infiltration of bacteria identified on routine and/or special (Brown-Hopps) stains.\nsynonyms :Renal tubulointerstitial bacterial organisms\n'}


{'id': 'HP_0020205', 'url': 'http://purl.obolibrary.org/obo/HP_0020205', 'lbl': 'Tubulointerstitial fungal infiltration', 'desc': 'label: Tubulointerstitial fungal infiltration\ndefinition : Tubulointerstitial infiltration of yeast or hyphal-microrganisms identified on routine and/or special (PAS, silver) stains.\nsynonyms :Renal tubulointerstitial fungal organisms\n'}


{'id': 'HP_0020206', 'url': 'http://purl.obolibrary.org/obo/HP_0020206', 'lbl': 'Simple ear', 'desc': 'label: Simple ear\ndefinition : The pinna has fewer folds and grooves than usual.\nsynonyms :\n'}


{'id': 'HP_0020207', 'url': 'http://purl.obolibrary.org/obo/HP_0020207', 'lbl': 'Reflex seizure', 'desc': 'label: Reflex seizure\ndefinition : Seizures precipitated by exogenous stimuli.\nsynonyms :\n'}


{'id': 'HP_0020208', 'url': 'http://purl.obolibrary.org/obo/HP_0020208', 'lbl': 'Eating-induced seizure', 'desc': 'label: Eating-induced seizure\ndefinition : A seizure precipitated by aspects of anticipating food, eating itself, or the post-prandial period.\nsynonyms :\n'}


{'id': 'HP_0020209', 'url': 'http://purl.obolibrary.org/obo/HP_0020209', 'lbl': 'Hot water-induced seizure', 'desc': 'label: Hot water-induced seizure\ndefinition : A seizure precipitated by pouring cupfuls of very hot water (40 to 50 degrees Celsius) in rapid succession over the head. Bathing in this manner is the most common trigger.\nsynonyms :\n'}


{'id': 'HP_0020210', 'url': 'http://purl.obolibrary.org/obo/HP_0020210', 'lbl': 'Praxis-induced seizure', 'desc': 'label: Praxis-induced seizure\ndefinition : A seizure precipitated by complex, cognition-guided tasks often involving visuomotor coordination and decision-making.\nsynonyms :\n'}


{'id': 'HP_0020211', 'url': 'http://purl.obolibrary.org/obo/HP_0020211', 'lbl': 'Proprioceptive-induced seizure', 'desc': 'label: Proprioceptive-induced seizure\ndefinition : A seizure precipitated by movement or a change in posture.\nsynonyms :\n'}


{'id': 'HP_0020212', 'url': 'http://purl.obolibrary.org/obo/HP_0020212', 'lbl': 'Reading-induced seizure', 'desc': 'label: Reading-induced seizure\ndefinition : A seizure precipitated by reading.\nsynonyms :\n'}


{'id': 'HP_0020213', 'url': 'http://purl.obolibrary.org/obo/HP_0020213', 'lbl': 'Somatosensory-induced seizure', 'desc': 'label: Somatosensory-induced seizure\ndefinition : A somatosensory reflex seizure is a seizure precipitated by somatic stimulation of a specific part of the body in the absence of startle or surprise.\nsynonyms :\n'}


{'id': 'HP_0020214', 'url': 'http://purl.obolibrary.org/obo/HP_0020214', 'lbl': 'Startle-induced seizure', 'desc': 'label: Startle-induced seizure\ndefinition : Startle-induced seizures are triggered by multiple and non-specific stimuli (auditory, somatosensory, and rarely visual) and are characterized by their sudden unexpected nature. Sudden noise rather than pure sound is the most effective acoustic stimulus.\nsynonyms :\n'}


{'id': 'HP_0020215', 'url': 'http://purl.obolibrary.org/obo/HP_0020215', 'lbl': 'Thinking-induced seizure', 'desc': 'label: Thinking-induced seizure\ndefinition : Seizures induced by thinking and decision-making.\ncomment:\nsynonyms :Cognition induced seizure\n'}


{'id': 'HP_0020216', 'url': 'http://purl.obolibrary.org/obo/HP_0020216', 'lbl': 'Visually-induced seizure', 'desc': 'label: Visually-induced seizure\ndefinition : Seizures evoked by visual stimuli. This includes clinical seizures induced by strobe lighting, television and other screens, flickering environmental lighting and self-induction by causing a strobe effect.\nsynonyms :Photosensitive seizure\n'}


{'id': 'HP_0020217', 'url': 'http://purl.obolibrary.org/obo/HP_0020217', 'lbl': 'Focal aware motor seizure', 'desc': 'label: Focal aware motor seizure\ndefinition : A type of focal motor seizure in which awareness is retained throughout the seizure.\nsynonyms :Focal motor aware seizure\n'}


{'id': 'HP_0020218', 'url': 'http://purl.obolibrary.org/obo/HP_0020218', 'lbl': 'Focal aware atonic seizure', 'desc': 'label: Focal aware atonic seizure\ndefinition : A type of focal atonic seizure during which awareness is fully retained throughout.\nsynonyms :\n'}


{'id': 'HP_0020219', 'url': 'http://purl.obolibrary.org/obo/HP_0020219', 'lbl': 'Motor seizure', 'desc': 'label: Motor seizure\ndefinition : A motor seizure is a type of seizure that is characterized at onset by involvement of the skeletal musculature. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement.\nsynonyms :\n'}


{'id': 'HP_0020220', 'url': 'http://purl.obolibrary.org/obo/HP_0020220', 'lbl': 'Focal atonic seizure', 'desc': 'label: Focal atonic seizure\ndefinition : A focal seizure characterized at onset by sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic activity, typically lasting more than 500 ms but less than 2 seconds. It may involve the head, trunk, jaw or limb musculature.\nsynonyms :Localised atonic seizure; Localised hypotonic seizure; Localized atonic seizure; Localized hypotonic seizure; Partial atonic seizure; Partial hypotonic seizure; Segmental atonic seizure; Segmental hypotonic seizure\n'}


{'id': 'HP_0020221', 'url': 'http://purl.obolibrary.org/obo/HP_0020221', 'lbl': 'Clonic seizure', 'desc': 'label: Clonic seizure\ndefinition : A clonic seizure is a type of motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive.\nsynonyms :\n'}


{'id': 'HP_0020222', 'url': 'http://purl.obolibrary.org/obo/HP_0020222', 'lbl': 'Hypohomocysteinemia', 'desc': 'label: Hypohomocysteinemia\ndefinition : A decreased concentration of homocystine in the blood.\nsynonyms :\n'}


{'id': 'HP_0020223', 'url': 'http://purl.obolibrary.org/obo/HP_0020223', 'lbl': 'Dermal sinus tract', 'desc': 'label: Dermal sinus tract\ndefinition : A dermal sinus tract is an abnormality present at birth over the dorsal midline where an abnormal epithelialized connection from the skin tracks inwards towards the spine, most commonly seen in the lumbosacral region.\nsynonyms :\n'}


{'id': 'HP_0025004', 'url': 'http://purl.obolibrary.org/obo/HP_0025004', 'lbl': 'Hallux rigidus', 'desc': 'label: Hallux rigidus\ndefinition : Osteoarthritis of the metatarsophalangeal joint of the first toe.\nsynonyms :Arthritis of the big toe\n'}


{'id': 'HP_0025005', 'url': 'http://purl.obolibrary.org/obo/HP_0025005', 'lbl': 'Thickening of glomerular capillary wall', 'desc': 'label: Thickening of glomerular capillary wall\ndefinition : Widening of the wall of capillary blood vessels in the glomerulus. This feature may be produced by deposits and other changes affecting either subepithelial and subendothelial regions or the glomerular basement membrane itself.\nsynonyms :\n'}


{'id': 'HP_0025006', 'url': 'http://purl.obolibrary.org/obo/HP_0025006', 'lbl': 'Abnormal glomerular capillary morphology', 'desc': 'label: Abnormal glomerular capillary morphology\ndefinition : A structural anomaly of the capillary blood vessels in the renal glomerulus.\nsynonyms :Abnormalities of the glomerular capillary wall\n'}


{'id': 'HP_0025007', 'url': 'http://purl.obolibrary.org/obo/HP_0025007', 'lbl': 'Ectopic fovea', 'desc': 'label: Ectopic fovea\ndefinition : An abnormal anatomic position of the fovea, the small, central pit composed of closely packed cones that is located in the macula of the retina.\nsynonyms :Ectopic macula\n'}


{'id': 'HP_0025008', 'url': 'http://purl.obolibrary.org/obo/HP_0025008', 'lbl': 'Tracheal tug on inspiration', 'desc': 'label: Tracheal tug on inspiration\ndefinition : Downward movement of the trachea during inspiration due to downward traction on the tracheobronchial tree.\nsynonyms :\n'}


{'id': 'HP_0025009', 'url': 'http://purl.obolibrary.org/obo/HP_0025009', 'lbl': 'Forward slanting upper incisors', 'desc': 'label: Forward slanting upper incisors\ndefinition : The upper incisors deviate from the normal angle of being roughly parallel to the surface of the face and instead slant outwards.\nsynonyms :Forward directed upper incisors; Proclination of the upper incisors; Protruding upper incisors\n'}


{'id': 'HP_0025010', 'url': 'http://purl.obolibrary.org/obo/HP_0025010', 'lbl': 'Foveal atrophy', 'desc': 'label: Foveal atrophy\ndefinition : Partial or complete loss of foveal tissue that was once present.\nsynonyms :\n'}


{'id': 'HP_0025011', 'url': 'http://purl.obolibrary.org/obo/HP_0025011', 'lbl': 'Pyriform aperture stenosis', 'desc': 'label: Pyriform aperture stenosis\ndefinition : Narrowing of the anterior nasal aperture (piriform or pyriform aperture), which is a pear-shaped opening in the skull that forms the bony inlet of the nose.\nsynonyms :\n'}


{'id': 'HP_0025012', 'url': 'http://purl.obolibrary.org/obo/HP_0025012', 'lbl': 'Status cribrosum', 'desc': 'label: Status cribrosum\ndefinition : Diffusely widened perivascular spaces in the basal ganglia, affecting especially the corpus striatum. Status cribrosum is usually symmetrical, with the perivascular spaces showing CSF signal and without diffusion restriction. The word cribriform means sievelike, with multiple perforations.\nsynonyms :\n'}


{'id': 'HP_0025013', 'url': 'http://purl.obolibrary.org/obo/HP_0025013', 'lbl': 'Decerebrate rigidity', 'desc': 'label: Decerebrate rigidity\ndefinition : A type of rigidity that is manifested by an exaggerated extensor posture of all extremities.\nsynonyms :Decerebrate posturing\n'}


{'id': 'HP_0025014', 'url': 'http://purl.obolibrary.org/obo/HP_0025014', 'lbl': 'Subcutaneous spheroids', 'desc': 'label: Subcutaneous spheroids\ndefinition : Small, hard cyst-like nodules, freely moveable in the subcutis over the bony prominences of the legs and arms, which have an outer calcified layer with a translucent core on x-ray.\nsynonyms :\n'}


{'id': 'HP_0025015', 'url': 'http://purl.obolibrary.org/obo/HP_0025015', 'lbl': 'Abnormal vascular morphology', 'desc': 'label: Abnormal vascular morphology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0025016', 'url': 'http://purl.obolibrary.org/obo/HP_0025016', 'lbl': 'Abnormal capillary morphology', 'desc': 'label: Abnormal capillary morphology\ndefinition : A structural anomaly of the tiny blood vessels that connect arterioles with venules and whose walls act as semipermeable membranes that mediate the diffusion of fluids and gases between the blood circulation and body tissues.\nsynonyms :\n'}


{'id': 'HP_0025017', 'url': 'http://purl.obolibrary.org/obo/HP_0025017', 'lbl': 'Capillary fragility', 'desc': 'label: Capillary fragility\ndefinition : Reduced resistance to rupture of capillary blood vessels. Capillary fragility may manifest as a bleeding diathesis with spontaneous ecchymoses (bruises).\nsynonyms :\n'}


{'id': 'HP_0025018', 'url': 'http://purl.obolibrary.org/obo/HP_0025018', 'lbl': 'Abnormal capillary physiology', 'desc': 'label: Abnormal capillary physiology\ndefinition : A functional anomaly of the tiny blood vessels that connect arterioles with venules and whose walls act as semipermeable membranes that mediate the diffusion of fluids and gases between the blood circulation and body tissues.\nsynonyms :\n'}


{'id': 'HP_0025019', 'url': 'http://purl.obolibrary.org/obo/HP_0025019', 'lbl': 'Arterial rupture', 'desc': 'label: Arterial rupture\ndefinition : Sudden breakage of an artery leading to leakage of blood from the circulation.\nsynonyms :\n'}


{'id': 'HP_0025020', 'url': 'http://purl.obolibrary.org/obo/HP_0025020', 'lbl': 'Elevated prostate-specific antigen level', 'desc': 'label: Elevated prostate-specific antigen level\ndefinition : An increased concentration of prostate specific antigen (PSA) in the circulation.\nsynonyms :\n'}


{'id': 'HP_0025021', 'url': 'http://purl.obolibrary.org/obo/HP_0025021', 'lbl': 'Abnormal erythrocyte sedimentation rate', 'desc': 'label: Abnormal erythrocyte sedimentation rate\ndefinition : A deviation from normal range of the erythrocyte sedimentation rate (ESR), a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.\nsynonyms :Abnormal ESR; Abnormal Westergren sedimentation rate\n'}


{'id': 'HP_0025022', 'url': 'http://purl.obolibrary.org/obo/HP_0025022', 'lbl': 'Decreased erythrocyte sedimentation rate', 'desc': 'label: Decreased erythrocyte sedimentation rate\ndefinition : A reduced erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.\nsynonyms :Decreased ESR; Low ESR\n'}


{'id': 'HP_0025023', 'url': 'http://purl.obolibrary.org/obo/HP_0025023', 'lbl': 'Rectal atresia', 'desc': 'label: Rectal atresia\ndefinition : A developmental defect resulting in complete obliteration of the lumen of the rectum. That is, there is an abnormal closure, or atresia of the tubular structure of the rectum.\nsynonyms :Atresia of the rectum\n'}


{'id': 'HP_0025024', 'url': 'http://purl.obolibrary.org/obo/HP_0025024', 'lbl': 'Megarectum', 'desc': 'label: Megarectum\ndefinition : An abnormal dilation of the rectum. There is a large filled rectum as a result of underlying innervation or muscular abnormalities, which remains after disimpaction of the rectum.\nsynonyms :\n'}


{'id': 'HP_0025025', 'url': 'http://purl.obolibrary.org/obo/HP_0025025', 'lbl': 'Rectovestibular fistula', 'desc': 'label: Rectovestibular fistula\ndefinition : A congenital malformation characterized by an abnormal connection (fistula) between the rectum and the vulval vestibule, at the lower aspect of the vaginal opening.\nsynonyms :Vestibular fistula\n'}


{'id': 'HP_0025026', 'url': 'http://purl.obolibrary.org/obo/HP_0025026', 'lbl': 'H-type rectovestibular fistula', 'desc': 'label: H-type rectovestibular fistula\ndefinition : Rectovestibular fistula with a normal anus is known as H-type fistula or double termination of the alimentary tract.\nsynonyms :\n'}


{'id': 'HP_0025027', 'url': 'http://purl.obolibrary.org/obo/HP_0025027', 'lbl': 'Osteoma cutis', 'desc': 'label: Osteoma cutis\ndefinition : The term osteoma refers to the anomalous presence of ossification (bone formation) in the interior of the dermis or epidermis. The dermal or subcutaneous bone formation presents as stony hard nodules. The osteomata appear as irregular, hardened small nodules that are well circumscribed and generally of the same color as the skin.\nsynonyms :Cutaneous osteosis; Miliary osteoma; Osteomatosis\n'}


{'id': 'HP_0025028', 'url': 'http://purl.obolibrary.org/obo/HP_0025028', 'lbl': 'Abnormality of enteric nervous system morphology', 'desc': 'label: Abnormality of enteric nervous system morphology\ndefinition : A structural anomaly of nerves of the enteric nervous system.\nsynonyms :\n'}


{'id': 'HP_0025029', 'url': 'http://purl.obolibrary.org/obo/HP_0025029', 'lbl': 'Abnormality of enteric neuron morphology', 'desc': 'label: Abnormality of enteric neuron morphology\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0025030', 'url': 'http://purl.obolibrary.org/obo/HP_0025030', 'lbl': 'Enteric neuronal degeneration', 'desc': 'label: Enteric neuronal degeneration\ndefinition : Deterioration of enteric neurons with impairment of enteric neuronal structure. Typical neuropathological findings include qualitative (e.g., neuronal swelling, intranuclear inclusions, axonal degeneration) and quantitative (e.g., reduction in the number of neurons) abnormalities of the enteric neurons.\nsynonyms :Degenerative enteric neuropathy\n'}


{'id': 'HP_0025031', 'url': 'http://purl.obolibrary.org/obo/HP_0025031', 'lbl': 'Abnormality of the digestive system', 'desc': 'label: Abnormality of the digestive system\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0025032', 'url': 'http://purl.obolibrary.org/obo/HP_0025032', 'lbl': 'Abnormality of digestive system physiology', 'desc': 'label: Abnormality of digestive system physiology\ndefinition : A functional anomaly of the digestive system.\nsynonyms :\n'}


{'id': 'HP_0025033', 'url': 'http://purl.obolibrary.org/obo/HP_0025033', 'lbl': 'Abnormality of digestive system morphology', 'desc': 'label: Abnormality of digestive system morphology\ndefinition : A structural anomaly of the digestive system.\nsynonyms :\n'}


{'id': 'HP_0025034', 'url': 'http://purl.obolibrary.org/obo/HP_0025034', 'lbl': 'Abnormal morphology of erythroid progenitor cell', 'desc': 'label: Abnormal morphology of erythroid progenitor cell\ndefinition : Abnormal form of the progenitor cells committed to the erythroid lineage.\nsynonyms :\n'}


{'id': 'HP_0025035', 'url': 'http://purl.obolibrary.org/obo/HP_0025035', 'lbl': 'Abnormal proerythroblast morphology', 'desc': 'label: Abnormal proerythroblast morphology\ndefinition : Anomalous form of the proerythroblast, i.e., the immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.\nsynonyms :\n'}


{'id': 'HP_0025037', 'url': 'http://purl.obolibrary.org/obo/HP_0025037', 'lbl': 'Hypothalamic gliosis', 'desc': 'label: Hypothalamic gliosis\ndefinition : Focal proliferation of glial cells in the hypothalamus.\nsynonyms :\n'}


{'id': 'HP_0025038', 'url': 'http://purl.obolibrary.org/obo/HP_0025038', 'lbl': 'Intratesticular abscess', 'desc': 'label: Intratesticular abscess\ndefinition : A collection of pus within a testicle. Ultrasonographic features include shaggy, irregular walls, intratesticular location, low-level internal echoes, and occasionally, hypervascular margins.\nsynonyms :Testicular abscess\n'}


{'id': 'HP_0025039', 'url': 'http://purl.obolibrary.org/obo/HP_0025039', 'lbl': 'Basal ganglia edema', 'desc': 'label: Basal ganglia edema\ndefinition : Swelling within the basal ganglia due to the accumulation of fluid.\nsynonyms :Basal ganglia oedema; Edema of the basal ganglia; Oedema of the basal ganglia\n'}


{'id': 'HP_0025040', 'url': 'http://purl.obolibrary.org/obo/HP_0025040', 'lbl': 'Thalamic edema', 'desc': 'label: Thalamic edema\ndefinition : Swelling within the thalamus due to the accumulation of fluid.\nsynonyms :Edema of the thalamus; Oedema of the thalamus; Thalamic oedema\n'}


{'id': 'HP_0025041', 'url': 'http://purl.obolibrary.org/obo/HP_0025041', 'lbl': 'Thalamic calcification', 'desc': 'label: Thalamic calcification\ndefinition : Calcium deposition in the thalamus.\nsynonyms :\n'}


{'id': 'HP_0025042', 'url': 'http://purl.obolibrary.org/obo/HP_0025042', 'lbl': 'Abnormality of mesenteric lymph nodes', 'desc': 'label: Abnormality of mesenteric lymph nodes\ndefinition : A morphological anomaly of lymph nodes in the mesenteric root or throughout the mesentery.\nsynonyms :\n'}


{'id': 'HP_0025043', 'url': 'http://purl.obolibrary.org/obo/HP_0025043', 'lbl': 'Enlarged mesenteric lymph node', 'desc': 'label: Enlarged mesenteric lymph node\ndefinition : Increase in size of one or more mesenteric lymph nodes.\nsynonyms :\n'}


{'id': 'HP_0025044', 'url': 'http://purl.obolibrary.org/obo/HP_0025044', 'lbl': 'Lung abscess', 'desc': 'label: Lung abscess\ndefinition : A circumscribed area of pus or necrotic debris in lung parenchyma, which leads to a cavity, and after formation of bronchopulmonary fistula, can manifest as an air-fluid level inside the cavity.\nsynonyms :\n'}


{'id': 'HP_0025045', 'url': 'http://purl.obolibrary.org/obo/HP_0025045', 'lbl': 'Abnormal brain lactate level by MRS', 'desc': 'label: Abnormal brain lactate level by MRS\ndefinition : A deviation from normal of the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :Abnormal lactate level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025046', 'url': 'http://purl.obolibrary.org/obo/HP_0025046', 'lbl': 'Reduced brain lactate level by MRS', 'desc': 'label: Reduced brain lactate level by MRS\ndefinition : A decrease in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :Reduced brain lactate level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025047', 'url': 'http://purl.obolibrary.org/obo/HP_0025047', 'lbl': 'Abnormal brain choline level by MRS', 'desc': 'label: Abnormal brain choline level by MRS\ndefinition : A deviation from normal in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :Abnormal brain choline level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025048', 'url': 'http://purl.obolibrary.org/obo/HP_0025048', 'lbl': 'Reduced brain choline level by MRS', 'desc': 'label: Reduced brain choline level by MRS\ndefinition : An decrease in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :Reduced brain choline level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025049', 'url': 'http://purl.obolibrary.org/obo/HP_0025049', 'lbl': 'Abnormal brain creatine level by MRS', 'desc': 'label: Abnormal brain creatine level by MRS\ndefinition : \nsynonyms :Abnormal brain creatine level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025050', 'url': 'http://purl.obolibrary.org/obo/HP_0025050', 'lbl': 'Elevated brain creatine level by MRS', 'desc': 'label: Elevated brain creatine level by MRS\ndefinition : An increase in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :Elevated brain creatine level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025051', 'url': 'http://purl.obolibrary.org/obo/HP_0025051', 'lbl': 'Reduced brain creatine level by MRS', 'desc': 'label: Reduced brain creatine level by MRS\ndefinition : A decrease in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :Low brain creatine phosphate; Reduced brain creatine level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025052', 'url': 'http://purl.obolibrary.org/obo/HP_0025052', 'lbl': 'Abnormal brain N-acetyl aspartate level by MRS', 'desc': 'label: Abnormal brain N-acetyl aspartate level by MRS\ndefinition : A deviation from normal in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :Abnormal brain N-acetyl aspartate level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025053', 'url': 'http://purl.obolibrary.org/obo/HP_0025053', 'lbl': 'Elevated brain N-acetyl aspartate level by MRS', 'desc': 'label: Elevated brain N-acetyl aspartate level by MRS\ndefinition : An increase in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :Elevated brain N-acetyl aspartate level by magnetic resonance spectroscopy\n'}


{'id': 'HP_0025057', 'url': 'http://purl.obolibrary.org/obo/HP_0025057', 'lbl': 'Abnormality of olfactory lobe morphology', 'desc': 'label: Abnormality of olfactory lobe morphology\ndefinition : A structural anomaly of the olfactory lobe, the structure within the brain that receives neural input from the nasal cavity and thereby processes the sense of smell.\nsynonyms :\n'}


{'id': 'HP_0025058', 'url': 'http://purl.obolibrary.org/obo/HP_0025058', 'lbl': 'Hypothalamic atrophy', 'desc': 'label: Hypothalamic atrophy\ndefinition : Partial or complete wasting (loss) of hypothalamus tissue that was once present.\nsynonyms :Atrophy of the hypothalamus\n'}


{'id': 'HP_0025059', 'url': 'http://purl.obolibrary.org/obo/HP_0025059', 'lbl': 'Splenic abscess', 'desc': 'label: Splenic abscess\ndefinition : A circumscribed area of pus or necrotic debris in the parenchyma of the spleen.\nsynonyms :\n'}


{'id': 'HP_0025060', 'url': 'http://purl.obolibrary.org/obo/HP_0025060', 'lbl': 'Multifocal splenic abscess', 'desc': 'label: Multifocal splenic abscess\ndefinition : Multiple abscess lesions in the spleen.\nsynonyms :Multilocular splenic abscess\n'}


{'id': 'HP_0025061', 'url': 'http://purl.obolibrary.org/obo/HP_0025061', 'lbl': 'Unifocal splenic abscess', 'desc': 'label: Unifocal splenic abscess\ndefinition : Single (solitary) abscess in the spleen.\nsynonyms :Solitary splenic abscess; Unilocular splenic abscess\n'}


{'id': 'HP_0025062', 'url': 'http://purl.obolibrary.org/obo/HP_0025062', 'lbl': 'Geophagia', 'desc': 'label: Geophagia\ndefinition : The practice of eating earth or soil-like substrates such as clay or chalk.\nsynonyms :Geophagy\n'}


{'id': 'HP_0025063', 'url': 'http://purl.obolibrary.org/obo/HP_0025063', 'lbl': 'Scaphoid abdomen', 'desc': 'label: Scaphoid abdomen\ndefinition : The anterior abdominal wall is sunken and presents a concave rather than a convex contour.\nsynonyms :\n'}


{'id': 'HP_0025064', 'url': 'http://purl.obolibrary.org/obo/HP_0025064', 'lbl': 'Thalamic hemorrhage', 'desc': 'label: Thalamic hemorrhage\ndefinition : Bleeding in the thalamus.\nsynonyms :Thalamic haemorrhage\n'}


{'id': 'HP_0025065', 'url': 'http://purl.obolibrary.org/obo/HP_0025065', 'lbl': 'Abnormal mean corpuscular volume', 'desc': 'label: Abnormal mean corpuscular volume\ndefinition : A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.\nsynonyms :Abnormal MCV; Abnormal erythrocyte volume\n'}


{'id': 'HP_0025066', 'url': 'http://purl.obolibrary.org/obo/HP_0025066', 'lbl': 'Decreased mean corpuscular volume', 'desc': 'label: Decreased mean corpuscular volume\ndefinition : A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters).\nsynonyms :Decreased MCV; Microcytosis; Reduced erythrocyte volume\n'}


{'id': 'HP_0025068', 'url': 'http://purl.obolibrary.org/obo/HP_0025068', 'lbl': 'Incomitant strabismus', 'desc': 'label: Incomitant strabismus\ndefinition : Strabismus in which the angle of deviation differs depending upon the direction of gaze or according to which eye is fixing, associated with: (i) defective movement of the eye, (ii) asymmetrical accommodative effort.\nsynonyms :\n'}


{'id': 'HP_0025069', 'url': 'http://purl.obolibrary.org/obo/HP_0025069', 'lbl': 'Concomitant strabismus', 'desc': 'label: Concomitant strabismus\ndefinition : Strabismus in which the angle of deviation of the squiting eye remains the same in relation to the other eye, in all directions of gaze, and whichever eye is fixing.\nsynonyms :Comitant strabismus\n'}


{'id': 'HP_0025070', 'url': 'http://purl.obolibrary.org/obo/HP_0025070', 'lbl': 'Abnormal U wave', 'desc': 'label: Abnormal U wave\ndefinition : An anomaly of the U wave of the electrocardiogram (EKG). The U wave is a small (0.5 mm) deflection immediately following the T wave, usually in the same direction as the T wave. It is best seen in leads V2 and V3.\nsynonyms :\n'}


{'id': 'HP_0025071', 'url': 'http://purl.obolibrary.org/obo/HP_0025071', 'lbl': 'U wave inversion', 'desc': 'label: U wave inversion\ndefinition : Direction of the U wave opposite to the T wave (i.e., below baseline) in leads with upright T waves.\nsynonyms :\n'}


{'id': 'HP_0025072', 'url': 'http://purl.obolibrary.org/obo/HP_0025072', 'lbl': 'Prominent U wave', 'desc': 'label: Prominent U wave\ndefinition : Increased amplitude of the U wave, defined as an amplitude grerater than 1-2mm or 25 percent of the height of the T wave.\nsynonyms :Increased U wave amplitude\n'}


{'id': 'HP_0025073', 'url': 'http://purl.obolibrary.org/obo/HP_0025073', 'lbl': 'Exercise-induced U wave inversion', 'desc': 'label: Exercise-induced U wave inversion\ndefinition : U wave inversion that is induced by exercise stress testing.\nsynonyms :\n'}


{'id': 'HP_0025074', 'url': 'http://purl.obolibrary.org/obo/HP_0025074', 'lbl': 'Abnormal QRS complex', 'desc': 'label: Abnormal QRS complex\ndefinition : An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram.\nsynonyms :\n'}


{'id': 'HP_0025075', 'url': 'http://purl.obolibrary.org/obo/HP_0025075', 'lbl': 'Increased QRS voltage', 'desc': 'label: Increased QRS voltage\ndefinition : Elevation of the voltage (height) of the QRS complex. There are several criteria in use, but the most common is the Sokolov-Lyon criterion (S wave depth in V1 + tallest R wave height in V5-V6 greater than 35 mm).\nsynonyms :\n'}


{'id': 'HP_0025076', 'url': 'http://purl.obolibrary.org/obo/HP_0025076', 'lbl': 'Abnormal QRS voltage', 'desc': 'label: Abnormal QRS voltage\ndefinition : Abnormal amplitude of the QRS complex of the electrocardiogram (EKG).\nsynonyms :\n'}


{'id': 'HP_0025077', 'url': 'http://purl.obolibrary.org/obo/HP_0025077', 'lbl': 'Decreased QRS voltage', 'desc': 'label: Decreased QRS voltage\ndefinition : Reduced amplitude (height) of the QRS complex of the electrocardiogram (EKG), defined as amplitudes of all the QRS complexes in the limb leads are less than 5 mm or amplitudes of all the QRS complexes in the precordial leads less than 10 mm.\nsynonyms :\n'}


{'id': 'HP_0025078', 'url': 'http://purl.obolibrary.org/obo/HP_0025078', 'lbl': 'Electrical alternans', 'desc': 'label: Electrical alternans\ndefinition : The QRS complexes of the electrocardiogram alternate in height.\nsynonyms :\n'}


{'id': 'HP_0025079', 'url': 'http://purl.obolibrary.org/obo/HP_0025079', 'lbl': 'Pancreatic abscess', 'desc': 'label: Pancreatic abscess\ndefinition : A circumscribed area of pus or necrotic debris in the parenchyma of the pancreas.\nsynonyms :Pancreas abscess\n'}


{'id': 'HP_0025080', 'url': 'http://purl.obolibrary.org/obo/HP_0025080', 'lbl': 'Orthokeratotic hyperkeratosis', 'desc': 'label: Orthokeratotic hyperkeratosis\ndefinition : A form of hyperkeratosis characterized by thickening of the cornified layer without retained nuclei.\nsynonyms :\n'}


{'id': 'HP_0025081', 'url': 'http://purl.obolibrary.org/obo/HP_0025081', 'lbl': "Darier's sign", 'desc': "label: Darier's sign\ndefinition : A skin change elicited by briskly rubbing the skin lesion in urticaria pigmentosa (UP), whereby the area begins to itch and becomes raised and surrounded by erythema. Unlike other forms of dermatographism, Darier's sign refers to urtication that is limited to the UP involved areas and, as in this case, spares the skin unaffected by UP.\nsynonyms :\n"}


{'id': 'HP_0025082', 'url': 'http://purl.obolibrary.org/obo/HP_0025082', 'lbl': 'Abnormal cutaneous elastic fiber morphology', 'desc': 'label: Abnormal cutaneous elastic fiber morphology\ndefinition : Any structural anomaly of the elastic fibers of the skin. Elastic fibers are the essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils.\nsynonyms :Abnormal cutaneous elastic fibre morphology\n'}


{'id': 'HP_0025083', 'url': 'http://purl.obolibrary.org/obo/HP_0025083', 'lbl': 'Elevated dermal desmosine content', 'desc': 'label: Elevated dermal desmosine content\ndefinition : An increased amount of desmosine measure in the skin. Desmosine is a cross-linking amino acid formed from lysyl residues in elastin.\nsynonyms :\n'}


{'id': 'HP_0025084', 'url': 'http://purl.obolibrary.org/obo/HP_0025084', 'lbl': 'Folliculitis', 'desc': 'label: Folliculitis\ndefinition : Inflammatory cells within the wall and ostia of the hair follicle, creating a follicular-based pustule.\nsynonyms :Follicular pustule\n'}


{'id': 'HP_0025085', 'url': 'http://purl.obolibrary.org/obo/HP_0025085', 'lbl': 'Bloody diarrhea', 'desc': 'label: Bloody diarrhea\ndefinition : Passage of many stools containing blood.\nsynonyms :Blood in stool; Bloody stool; Bloody bowel movement; Bloody diarrhea; Bloody diarrhoea\n'}


{'id': 'HP_0025086', 'url': 'http://purl.obolibrary.org/obo/HP_0025086', 'lbl': 'Bloody mucoid diarrhea', 'desc': 'label: Bloody mucoid diarrhea\ndefinition : Passage of many stools containing blood and mucus.\nsynonyms :Bloody mucoid diarrhoea\n'}


{'id': 'HP_0025087', 'url': 'http://purl.obolibrary.org/obo/HP_0025087', 'lbl': 'Delayed recoil upon stretching of skin', 'desc': 'label: Delayed recoil upon stretching of skin\ndefinition : Area of skin requiring an increased amount of time to return to its original shape after being stretched.\nsynonyms :\n'}


{'id': 'HP_0025088', 'url': 'http://purl.obolibrary.org/obo/HP_0025088', 'lbl': 'Onychomadesis', 'desc': 'label: Onychomadesis\ndefinition : Complete shedding (separation) of the nail from the proximal matrix. Onychomadesis is the proximal separation of the nail plate from the nail matrix due to a temporary cessation of nail growth.\nsynonyms :\n'}


{'id': 'HP_0025089', 'url': 'http://purl.obolibrary.org/obo/HP_0025089', 'lbl': 'Feculent vomiting', 'desc': 'label: Feculent vomiting\ndefinition : Vomiting of material that is of fecal origin.\nsynonyms :Faecal vomiting; Fecal vomiting; Stercoraceous vomiting; Vomiting faecal matter; Vomiting fecal matter\n'}


{'id': 'HP_0025090', 'url': 'http://purl.obolibrary.org/obo/HP_0025090', 'lbl': 'Abnormal large intestinal mucosa morphology', 'desc': 'label: Abnormal large intestinal mucosa morphology\ndefinition : A structural anomaly of the mucous lining of the large intestine.\nsynonyms :\n'}


{'id': 'HP_0025092', 'url': 'http://purl.obolibrary.org/obo/HP_0025092', 'lbl': 'Epidermal acanthosis', 'desc': 'label: Epidermal acanthosis\ndefinition : Diffuse hypertrophy or thickening of the stratum spinosum of the epidermis (prickle cell layer of the skin).\nsynonyms :Acanthosis; Acanthotic epidermis; Thickening of upper layer of skin; Epidermal hyperplasia\n'}


{'id': 'HP_0025093', 'url': 'http://purl.obolibrary.org/obo/HP_0025093', 'lbl': 'Peripapillary exudate', 'desc': 'label: Peripapillary exudate\ndefinition : A retinal exudate in the area surrounding the optic nerve head.\nsynonyms :Peripapillary exudation\n'}


{'id': 'HP_0025094', 'url': 'http://purl.obolibrary.org/obo/HP_0025094', 'lbl': 'Disciform macular scar', 'desc': 'label: Disciform macular scar\ndefinition : A subretinal scar with a disc-like shape in the region of the macula.\nsynonyms :\n'}


{'id': 'HP_0025095', 'url': 'http://purl.obolibrary.org/obo/HP_0025095', 'lbl': 'Sneeze', 'desc': 'label: Sneeze\ndefinition : A sudden violent, spasmodic, audible expiration of breath through the nose and mouth.\nsynonyms :\n'}


{'id': 'HP_0025096', 'url': 'http://purl.obolibrary.org/obo/HP_0025096', 'lbl': 'Paroxysmal sneezing', 'desc': 'label: Paroxysmal sneezing\ndefinition : Unprovoked explosive pathological sneezing.\nsynonyms :\n'}


{'id': 'HP_0025097', 'url': 'http://purl.obolibrary.org/obo/HP_0025097', 'lbl': 'Eyelid myoclonus', 'desc': 'label: Eyelid myoclonus\ndefinition : Marked, involuntary jerking of the eyelids.\nsynonyms :Blepharoclonus; Eyelid myoclonia\n'}


{'id': 'HP_0025098', 'url': 'http://purl.obolibrary.org/obo/HP_0025098', 'lbl': 'Dysgenesis of the hypothalamus', 'desc': 'label: Dysgenesis of the hypothalamus\ndefinition : Structural abnormality of the hypothalamus related to defective development.\nsynonyms :Hypothalamic dysgenesis\n'}


{'id': 'HP_0025099', 'url': 'http://purl.obolibrary.org/obo/HP_0025099', 'lbl': 'Dysgenesis of the thalamus', 'desc': 'label: Dysgenesis of the thalamus\ndefinition : Structural abnormality of the thalamus related to defective development.\nsynonyms :Thalamic dysgenesis\n'}


{'id': 'HP_0025100', 'url': 'http://purl.obolibrary.org/obo/HP_0025100', 'lbl': 'Abnormal hippocampus morphology', 'desc': 'label: Abnormal hippocampus morphology\ndefinition : Any structural anomaly of the hippocampus,\nsynonyms :Abnormal morphology of the hippocampus; Abnormality of hippocampus morphology\n'}


{'id': 'HP_0025101', 'url': 'http://purl.obolibrary.org/obo/HP_0025101', 'lbl': 'Dysgenesis of the hippocampus', 'desc': 'label: Dysgenesis of the hippocampus\ndefinition : Structural abnormality of the hippocampus related to defective development.\nsynonyms :Hippocampal dysgenesis\n'}


{'id': 'HP_0025102', 'url': 'http://purl.obolibrary.org/obo/HP_0025102', 'lbl': 'Dysgenesis of the basal ganglia', 'desc': 'label: Dysgenesis of the basal ganglia\ndefinition : Structural abnormality of the basal ganglia related to defective development.\nsynonyms :Basal ganglia dysgenesis\n'}


{'id': 'HP_0025103', 'url': 'http://purl.obolibrary.org/obo/HP_0025103', 'lbl': 'Umbilicated nodule', 'desc': 'label: Umbilicated nodule\ndefinition : A type of skin nodule that has a small depression that resembles a navel (i.e., is umbilicated).\nsynonyms :\n'}


{'id': 'HP_0025104', 'url': 'http://purl.obolibrary.org/obo/HP_0025104', 'lbl': 'Capillary malformation', 'desc': 'label: Capillary malformation\ndefinition : A capillary malformation is a flat, sharply defined vascular stain of the skin. It may cover a large surface area or it may be scattered and appear as little islands of color. In a capillary maformation, the predominant vessels are small, slow-flow vessels (i.e., arterioles and postcapillary venules).\nsynonyms :\n'}


{'id': 'HP_0025105', 'url': 'http://purl.obolibrary.org/obo/HP_0025105', 'lbl': 'Nevus anemicus', 'desc': 'label: Nevus anemicus\ndefinition : A congenital skin lesion characterized by irregular hypopigmented macules that coalesce to form plaques and occur particularly on the chest. It is generally present at birth or develops in the first days of life. It is more common in females. Diagnosis is confirmed by applying gentle friction to the lesion and the surrounding skin and checking that the erythema produced in the healthy skin does not appear in the hypopigmented lesion. This pale macule becomes more conspicuous when the lesion and its surroundings are rubbed. The margin of the naevus is ill-defined and consists of an archipelago of small anaemic spots.\nsynonyms :Naevus anaemicus\n'}


{'id': 'HP_0025106', 'url': 'http://purl.obolibrary.org/obo/HP_0025106', 'lbl': 'Nevus roseus', 'desc': 'label: Nevus roseus\ndefinition : A variant of port-wine stain characterized by a pale red or even pink tone, in contrast to the darker hue of the port-wine stain. By analogy with the term port-wine stain, this variant rose-wine stain, or nevus roseus. Nevus roseus, however, cannot be definitely diagnosed until adulthood as port-wine stains are sometimes pink in children. While the natural history of port-wine stains includes hypertrophy, darkening, and nodularity, nevus roseus remains unchanged for life.\nsynonyms :\n'}


{'id': 'HP_0025107', 'url': 'http://purl.obolibrary.org/obo/HP_0025107', 'lbl': 'Cutis marmorata telangiectatica congenita', 'desc': 'label: Cutis marmorata telangiectatica congenita\ndefinition : A congenital vascular malformation that presents as localized or generalized erythematous-telangiectatic lesions with a reticular pattern; the lesions are almost always present at birth or develop in the first days of life. Cutis marmorata telangiectatica congenita (CMTC) appears as marble-like pattern (mottling) on the surface of the skin. In contrast to cutis marmorata, the marbling is more severe and always visible.\nsynonyms :\n'}


{'id': 'HP_0025108', 'url': 'http://purl.obolibrary.org/obo/HP_0025108', 'lbl': 'Angioma serpentinum', 'desc': 'label: Angioma serpentinum\ndefinition : Angioma serpiginosum consists of punctate, tightly packed telangiectatic lesions. Characteristic histopathological features are dilated and tortuous capillaries involving the uppermost part of the dermis.\nsynonyms :\n'}


{'id': 'HP_0025109', 'url': 'http://purl.obolibrary.org/obo/HP_0025109', 'lbl': 'Reduced red cell pyruvate kinase level', 'desc': 'label: Reduced red cell pyruvate kinase level\ndefinition : Decrease in the level of pyruvate kinase (PK) within erythrocytes. PK catalyzes the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.\nsynonyms :Reduced erythrocyte pyruvate kinase activity\n'}


{'id': 'HP_0025110', 'url': 'http://purl.obolibrary.org/obo/HP_0025110', 'lbl': 'Placoid macular lesion', 'desc': 'label: Placoid macular lesion\ndefinition : Yellow/white, sharply delineated lesion, typically of inflammatory nature, involving the macula.\nsynonyms :\n'}


{'id': 'HP_0025112', 'url': 'http://purl.obolibrary.org/obo/HP_0025112', 'lbl': 'Auditory sensitivity', 'desc': 'label: Auditory sensitivity\ndefinition : Decreased tolerance to sound.\nsynonyms :Noise sensitivity\n'}


{'id': 'HP_0025113', 'url': 'http://purl.obolibrary.org/obo/HP_0025113', 'lbl': 'Misophonia', 'desc': 'label: Misophonia\ndefinition : An adverse response (dislike) to sound no matter what volume the sound is, characterized by a strong negative reaction to soft sounds that can sometimes be further triggered by seeing the source of the offending sound.\nsynonyms :\n'}


{'id': 'HP_0025114', 'url': 'http://purl.obolibrary.org/obo/HP_0025114', 'lbl': 'Hypergranulosis', 'desc': 'label: Hypergranulosis\ndefinition : Hypergranulosis is an increased thickness of the stratum granulosum.\nsynonyms :\n'}


{'id': 'HP_0025115', 'url': 'http://purl.obolibrary.org/obo/HP_0025115', 'lbl': 'Civatte bodies', 'desc': 'label: Civatte bodies\ndefinition : Eosinophilic hyaline ovoid bodies which are often found in the subepidermal papillary regions or sometimes in the epidermis. Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue. They are known as CBs (in epithelium/epidermis), colloid bodies, or hyaline bodies (in connective tissue). They are 10-25 micrometers in diameter and situated mostly within or above the inflammatory cell infiltrate. In lichen planus, the number of necrotic keratinocytes may be so large that they are seen lying in clusters in the uppermost dermis. These bodies show a positive periodic acid Schiff reaction and are diastase resistant\nsynonyms :Colloid bodies; Colloid bodies of Civatte; Cytoid bodies; Hyaline bodies\n'}


{'id': 'HP_0025116', 'url': 'http://purl.obolibrary.org/obo/HP_0025116', 'lbl': 'Fetal distress', 'desc': 'label: Fetal distress\ndefinition : An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile.\nsynonyms :Foetal distress\n'}


{'id': 'HP_0025117', 'url': 'http://purl.obolibrary.org/obo/HP_0025117', 'lbl': 'Rete ridge flattening', 'desc': 'label: Rete ridge flattening\ndefinition : Rete pegs (or ridges) are the epithelial extensions that project into the underlying connective tissue in both skin and mucous membranes. Rete ridge flattening refers to the loss of these projections so that the skin epithelium acquires a relatively flat appearance.\nsynonyms :Flattened rete pegs; Flattened rete ridges\n'}


{'id': 'HP_0025118', 'url': 'http://purl.obolibrary.org/obo/HP_0025118', 'lbl': 'Lip discoloration', 'desc': 'label: Lip discoloration\ndefinition : Lightening or darkening of the lips from their usual coloring.\nsynonyms :\n'}


{'id': 'HP_0025119', 'url': 'http://purl.obolibrary.org/obo/HP_0025119', 'lbl': 'Violet lip discoloration', 'desc': 'label: Violet lip discoloration\ndefinition : An alteration of the color of the lip to take on a violet color. This term does not include cyanosis.\nsynonyms :\n'}


{'id': 'HP_0025121', 'url': 'http://purl.obolibrary.org/obo/HP_0025121', 'lbl': 'obsolete Simple partial occipital seizures', 'desc': 'label: obsolete Simple partial occipital seizures\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0025122', 'url': 'http://purl.obolibrary.org/obo/HP_0025122', 'lbl': 'Sawtooth acanthosis', 'desc': 'label: Sawtooth acanthosis\ndefinition : A type of epidermal acanthosis characterized by a jagged (sawtooth) appearance of the rete ridges of the epidermis.\nsynonyms :Sawtoothed acanthosis\n'}


{'id': 'HP_0025123', 'url': 'http://purl.obolibrary.org/obo/HP_0025123', 'lbl': 'White streaks/specks on enamel.', 'desc': 'label: White streaks/specks on enamel.\ndefinition : Areas of white discoloration visible on the surface of the teeth (enamel) in the form of streaks or specks.\nsynonyms :\n'}


{'id': 'HP_0025124', 'url': 'http://purl.obolibrary.org/obo/HP_0025124', 'lbl': 'Fragile teeth', 'desc': 'label: Fragile teeth\ndefinition : A tendency of teeth to fracture as manifested by a history of repeated fracture of the dental enamel without adequate trauma.\nsynonyms :Enamel with tendency to chip; Spontaneous tooth fracture\n'}


{'id': 'HP_0025125', 'url': 'http://purl.obolibrary.org/obo/HP_0025125', 'lbl': 'White lesion of the oral mucosa', 'desc': 'label: White lesion of the oral mucosa\ndefinition : White lesions of the oral mucosa are generally caused by a condition that increases the thickness of the epithelium. This increases the distance to the vascular bed and thereby tends to change the usual reddish color of the oral mucosa to white. Common causes include hyperkeratosis (thickening of the keratin layer), acanthosis (thickening of the spinous cell layer), increased edema in the epithelium (leukoedema), and reduced vascularity of the underlying lamina propria. Additionally, fibrin caps or surface ulcerations and collapsed bullae can appear white.\nsynonyms :\n'}


{'id': 'HP_0025126', 'url': 'http://purl.obolibrary.org/obo/HP_0025126', 'lbl': 'Oral hairy leukoplakia', 'desc': 'label: Oral hairy leukoplakia\ndefinition : A corrugated white lesion of the oral mucosa that usually occurs on the lateral or ventral surfaces of the tongue and may have a shaggy or frayed appearance.\nsynonyms :\n'}


{'id': 'HP_0025127', 'url': 'http://purl.obolibrary.org/obo/HP_0025127', 'lbl': 'Actinic keratosis', 'desc': 'label: Actinic keratosis\ndefinition : A scaly, crusty lesion caused by damage from the ultraviolet radiation of the sun, with typical location on sun-exposed areas of the skin. Actinic keratosis lesions are often elevated, rough, and wartlike, and may be red, or occasionally tan, pink, or flesh-toned in color.\nsynonyms :Solar keratosis\n'}


{'id': 'HP_0025128', 'url': 'http://purl.obolibrary.org/obo/HP_0025128', 'lbl': 'Reduced intraabdominal adipose tissue', 'desc': 'label: Reduced intraabdominal adipose tissue\ndefinition : An abnormally reduced amount of adipose tissue in the abdominal cavity.\nsynonyms :\n'}


{'id': 'HP_0025129', 'url': 'http://purl.obolibrary.org/obo/HP_0025129', 'lbl': 'Abnormal small intestinal mucosa morphology', 'desc': 'label: Abnormal small intestinal mucosa morphology\ndefinition : A structural anomaly of the mucous lining of the small intestine.\nsynonyms :\n'}


{'id': 'HP_0025130', 'url': 'http://purl.obolibrary.org/obo/HP_0025130', 'lbl': 'Decreased small intestinal mucosa lactase level', 'desc': 'label: Decreased small intestinal mucosa lactase level\ndefinition : Lactase is produced in the small intestine in humans, Lactase is a member of the beta-galactosidase family of enzymes, and hydrolyzes D-lactose to form D-galactose and D-glucose, which can be absorbed by the small intestine. There are many ways of assessing lactase activity. In one test, an endoscopic biopsy from the postbulbar duodenum is incubated with lactose on a test plate, and a color reaction develops within 20 min as a result of hydrolyzed lactose (a positive result) in patients with normolactasia, whereas no reaction (a negative result) develops in patients with severe hypolactasia. Other, less direct, tests include the hydrogen breath test, and blood tests following lactose challenges.\nsynonyms :Lactase deficiency\n'}


{'id': 'HP_0025131', 'url': 'http://purl.obolibrary.org/obo/HP_0025131', 'lbl': 'Finger swelling', 'desc': 'label: Finger swelling\ndefinition : Enlargement of the soft tissues of one or more fingers.\nsynonyms :Swelling of fingers; Swollen finger; Swollen fingers\n'}


{'id': 'HP_0025132', 'url': 'http://purl.obolibrary.org/obo/HP_0025132', 'lbl': 'Abnormal circulating estrogen level', 'desc': 'label: Abnormal circulating estrogen level\ndefinition : A deviation from normal concentration of the hormone estrogen in the blood circulation.\nsynonyms :Abnormal circulating oestrogen level; Abnormal estrogen level; Abnormal oestrogen level\n'}


{'id': 'HP_0025133', 'url': 'http://purl.obolibrary.org/obo/HP_0025133', 'lbl': 'Abnormal serum estradiol', 'desc': 'label: Abnormal serum estradiol\ndefinition : A deviation from normal concentrations of estradiol in the circulation.\nsynonyms :\n'}


{'id': 'HP_0025134', 'url': 'http://purl.obolibrary.org/obo/HP_0025134', 'lbl': 'Increased serum estradiol', 'desc': 'label: Increased serum estradiol\ndefinition : An elevation above normal limits of the concentration of estradiol in the circulation.\nsynonyms :Increased estradiol level; Increased serum oestradiol\n'}


{'id': 'HP_0025135', 'url': 'http://purl.obolibrary.org/obo/HP_0025135', 'lbl': 'Abnormal serum estriol', 'desc': 'label: Abnormal serum estriol\ndefinition : A deviation from normal concentration of estriol in the circulation.\nsynonyms :\n'}


{'id': 'HP_0025136', 'url': 'http://purl.obolibrary.org/obo/HP_0025136', 'lbl': 'Increased serum estriol', 'desc': 'label: Increased serum estriol\ndefinition : An elevation above normal limits of estriol concentration in the circulation.\nsynonyms :\n'}


{'id': 'HP_0025137', 'url': 'http://purl.obolibrary.org/obo/HP_0025137', 'lbl': 'Decreased serum estriol', 'desc': 'label: Decreased serum estriol\ndefinition : A reduction below normal limits of estriol in the circulation.\nsynonyms :\n'}


{'id': 'HP_0025138', 'url': 'http://purl.obolibrary.org/obo/HP_0025138', 'lbl': 'Abnormal serum estrone', 'desc': 'label: Abnormal serum estrone\ndefinition : A deviation from the normal concentration of circulating estrone.\nsynonyms :\n'}


{'id': 'HP_0025139', 'url': 'http://purl.obolibrary.org/obo/HP_0025139', 'lbl': 'Increased serum estrone', 'desc': 'label: Increased serum estrone\ndefinition : An elevation above normal limits of the concentration of estrone in the circulation.\nsynonyms :\n'}


{'id': 'HP_0025140', 'url': 'http://purl.obolibrary.org/obo/HP_0025140', 'lbl': 'Decreased serum estrone', 'desc': 'label: Decreased serum estrone\ndefinition : A reduction below normal limits of the concentration of estrone in the circulation.\nsynonyms :\n'}


{'id': 'HP_0025141', 'url': 'http://purl.obolibrary.org/obo/HP_0025141', 'lbl': 'Gingival calcification', 'desc': 'label: Gingival calcification\ndefinition : Ectopic deposition of calcium salts found in the gingiva.\nsynonyms :Gingival calcifications\n'}


{'id': 'HP_0025142', 'url': 'http://purl.obolibrary.org/obo/HP_0025142', 'lbl': 'Constitutional symptom', 'desc': 'label: Constitutional symptom\ndefinition : A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.\nsynonyms :\n'}


{'id': 'HP_0025143', 'url': 'http://purl.obolibrary.org/obo/HP_0025143', 'lbl': 'Chills', 'desc': 'label: Chills\ndefinition : A sudden sensation of feeling cold.\nsynonyms :Chills\n'}


{'id': 'HP_0025144', 'url': 'http://purl.obolibrary.org/obo/HP_0025144', 'lbl': 'Shivering', 'desc': 'label: Shivering\ndefinition : Involuntary contraction or twitching of the muscles.\nsynonyms :Shivering; Shuddering\n'}


{'id': 'HP_0025145', 'url': 'http://purl.obolibrary.org/obo/HP_0025145', 'lbl': 'Rigors', 'desc': 'label: Rigors\ndefinition : Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever.\nsynonyms :Rigours\n'}


{'id': 'HP_0025146', 'url': 'http://purl.obolibrary.org/obo/HP_0025146', 'lbl': 'Foveal degeneration', 'desc': 'label: Foveal degeneration\ndefinition : Deterioration of the tissue of the fovea, i.e.,the region of sharpest vision within the macula of the retina.\nsynonyms :\n'}


{'id': 'HP_0025147', 'url': 'http://purl.obolibrary.org/obo/HP_0025147', 'lbl': 'Beaten bronze macular sheen', 'desc': 'label: Beaten bronze macular sheen\ndefinition : A shiny appearance of the macula, which is often called a beaten bronze appearance.\nsynonyms :Beaten metal macular appearance; Beaten-bronze macular appearance; Beaten-bronze macular sheen\n'}


{'id': 'HP_0025148', 'url': 'http://purl.obolibrary.org/obo/HP_0025148', 'lbl': 'Dark choroid', 'desc': 'label: Dark choroid\ndefinition : A fluorescein angiographic finding of absence of the normal background fluorescence (a dark choroid).\nsynonyms :\n'}


{'id': 'HP_0025149', 'url': 'http://purl.obolibrary.org/obo/HP_0025149', 'lbl': 'Atrophic muscularis propria', 'desc': 'label: Atrophic muscularis propria\ndefinition : Partial or complete wasting (loss) of muscularois propria tissue that was once present. The atrophy may involve a marked vacuolar degeneration of myocytes, loss of muscle fibers and some cases a highly characteristic honeycomb fibrosis.\nsynonyms :Autonomic visceral myopathy; Degenerative enteric myopathy\n'}


{'id': 'HP_0025150', 'url': 'http://purl.obolibrary.org/obo/HP_0025150', 'lbl': 'Hypoganglionosis', 'desc': 'label: Hypoganglionosis\ndefinition : Sparse and small myenteric ganglia\nsynonyms :\n'}


{'id': 'HP_0025151', 'url': 'http://purl.obolibrary.org/obo/HP_0025151', 'lbl': 'Ganglioneuromatosis', 'desc': 'label: Ganglioneuromatosis\ndefinition : Hyperplastic submucosal and myenteric plexus containing an increased number of ganglion cells, glial cells and nerve fibers.\nsynonyms :\n'}


{'id': 'HP_0025152', 'url': 'http://purl.obolibrary.org/obo/HP_0025152', 'lbl': 'Poor visual behavior for age', 'desc': 'label: Poor visual behavior for age\ndefinition : Lack of visual responsiveness or decrease in visual capabilities suggesting a lack of visual responsiveness or decrease in visual capabilities in an infant or young child in which visual behavior fails to meet normal developmental milestones.\nsynonyms :Abnormal visual behavior for age; Abnormal visual behaviour for age; Poor visual behaviour for age\n'}


{'id': 'HP_0025153', 'url': 'http://purl.obolibrary.org/obo/HP_0025153', 'lbl': 'Transient', 'desc': 'label: Transient\ndefinition : Short-lived and not permanent. This term applies to a phenotypic abnormality that is temporary and of short duration.\nsynonyms :\n'}


{'id': 'HP_0025154', 'url': 'http://purl.obolibrary.org/obo/HP_0025154', 'lbl': 'Portosystemic collateral veins', 'desc': 'label: Portosystemic collateral veins\ndefinition : Presence of biliary veins that serve as a collateral channel to the systemic circulation\nsynonyms :Collateral biliary circulation; Collateral biliary veins\n'}


{'id': 'HP_0025155', 'url': 'http://purl.obolibrary.org/obo/HP_0025155', 'lbl': 'Abnormality of hepatobiliary system physiology', 'desc': 'label: Abnormality of hepatobiliary system physiology\ndefinition : A functional anomaly of the hepatobiliary system\nsynonyms :\n'}


{'id': 'HP_0025156', 'url': 'http://purl.obolibrary.org/obo/HP_0025156', 'lbl': 'Dependency on intravenous nutrition', 'desc': 'label: Dependency on intravenous nutrition\ndefinition : Inability to be weaned from intravenous (parenteral) nutrition, as judged by the hydration status (urine output, blood urea nitrogen, creatinine, urine sodium concentration), ability to maintain weight, stool output, and serum electrolyte status.\nsynonyms :Dependency on IV nutrition\n'}


{'id': 'HP_0025157', 'url': 'http://purl.obolibrary.org/obo/HP_0025157', 'lbl': 'Increased urinary sedoheptulose', 'desc': 'label: Increased urinary sedoheptulose\ndefinition : An increased concentration of sedoheptulose in the urine. Sedoheptulose is a monosaccharide with seven carbon atoms and a ketone functional group.\nsynonyms :\n'}


{'id': 'HP_0025158', 'url': 'http://purl.obolibrary.org/obo/HP_0025158', 'lbl': 'Hyperautofluorescent retinal lesion', 'desc': 'label: Hyperautofluorescent retinal lesion\ndefinition : Increased amount of autofluorescence in the retina as ascertained by fundus autofluorescence imaging.\nsynonyms :\n'}


{'id': 'HP_0025159', 'url': 'http://purl.obolibrary.org/obo/HP_0025159', 'lbl': 'Hypoautofluorescent retinal lesion', 'desc': 'label: Hypoautofluorescent retinal lesion\ndefinition : Decreased amount of autofluorescence in the retina as ascertained by fundus autofluorescence imaging.\nsynonyms :Hypo-autofluorescent retinal lesion\n'}


{'id': 'HP_0025160', 'url': 'http://purl.obolibrary.org/obo/HP_0025160', 'lbl': 'Abnormal temper tantrums', 'desc': 'label: Abnormal temper tantrums\ndefinition : A temper tantrum is an emotional outburst usually triggered by a sense of frustration and manifested as whining and crying, screaming, kicking, hitting, and breath holding. Temper tantrums are normal in toddlers and young children and usually happen between the ages of one to three years. Temper tantrums may be considered abnormal if they occur at an unusually high frequency, are of unusual severity, or occur at an old age than usual.\nsynonyms :\n'}


{'id': 'HP_0025161', 'url': 'http://purl.obolibrary.org/obo/HP_0025161', 'lbl': 'Frequent temper tantrums', 'desc': 'label: Frequent temper tantrums\ndefinition : Temper tantrums that occur more frequently than usual.\nsynonyms :\n'}


{'id': 'HP_0025162', 'url': 'http://purl.obolibrary.org/obo/HP_0025162', 'lbl': 'Severe temper tantrums', 'desc': 'label: Severe temper tantrums\ndefinition : Temper tantrums whose severity is more severe than usual. For instance, a temper tantrum might be considered to be severe if a child loses control so completely that the child cannot control the tantrum on its own, continuing until it becomes exhausted or a parent intervenes.\nsynonyms :\n'}


{'id': 'HP_0025163', 'url': 'http://purl.obolibrary.org/obo/HP_0025163', 'lbl': 'Abnormality of optic chiasm morphology', 'desc': 'label: Abnormality of optic chiasm morphology\ndefinition : A structural abnormality of the optic chiasm.The optic chiasm, located below the hypothalamus, is a partial crossing of the optic nerves.\nsynonyms :\n'}


{'id': 'HP_0025164', 'url': 'http://purl.obolibrary.org/obo/HP_0025164', 'lbl': 'Increased number of elastic fibers in the dermis', 'desc': 'label: Increased number of elastic fibers in the dermis\ndefinition : An elevated number of elastic fibers, that is of bundles of proteins and glycoproteins in the extracellular matrix in the reticular dermis. Elastic fibers can stretch and recoil back to their original length. This feature can be appreciated on histology with hematoxylin and eosin or other staining methods.\nsynonyms :Increased number of elastic fibres in the dermis\n'}


{'id': 'HP_0025165', 'url': 'http://purl.obolibrary.org/obo/HP_0025165', 'lbl': 'Clumping of elastic fibers in the dermis', 'desc': 'label: Clumping of elastic fibers in the dermis\ndefinition : Formation of clumps or aggregates that make up small protuberances from elastic fibers within the dermis (especially the reticular dermis).\nsynonyms :Clumping of elastic fibres in the dermis\n'}


{'id': 'HP_0025166', 'url': 'http://purl.obolibrary.org/obo/HP_0025166', 'lbl': 'Thickened elastic fibers in the dermis', 'desc': 'label: Thickened elastic fibers in the dermis\ndefinition : An increase of the diameter of elastic fibers in the dermis.\nsynonyms :Thickened elastic fibres in the dermis\n'}


{'id': 'HP_0025167', 'url': 'http://purl.obolibrary.org/obo/HP_0025167', 'lbl': 'Fragmented elastic fibers in the dermis', 'desc': 'label: Fragmented elastic fibers in the dermis\ndefinition : Elastic fibers in the dermis exhibit an increased number of breaks associated with disorganization of the structure of the elastic fibers.\nsynonyms :Fragmented elastic fibres in the dermis\n'}


{'id': 'HP_0025168', 'url': 'http://purl.obolibrary.org/obo/HP_0025168', 'lbl': 'Left ventricular diastolic dysfunction', 'desc': 'label: Left ventricular diastolic dysfunction\ndefinition : Abnormal function of the left ventricule during left ventricular relaxation and filling.\nsynonyms :\n'}


{'id': 'HP_0025169', 'url': 'http://purl.obolibrary.org/obo/HP_0025169', 'lbl': 'Left ventricular systolic dysfunction', 'desc': 'label: Left ventricular systolic dysfunction\ndefinition : Abnormality of left ventricular contraction, often defined operationally as an ejection fraction of less than 40 percent.\nsynonyms :\n'}


{'id': 'HP_0025170', 'url': 'http://purl.obolibrary.org/obo/HP_0025170', 'lbl': 'Neuronal/glioneuronal neoplasm of the central nervous system', 'desc': 'label: Neuronal/glioneuronal neoplasm of the central nervous system\ndefinition : A central nervous system neoplasm with neuronal and, less consistently, glial differentiation.\nsynonyms :Glioneuronal tumor; Glioneuronal tumour; Neuronal and mixed neuronal-glial tumor; Neuronal and mixed neuronal-glial tumour; Neuronal/glioneuronal neoplasm of the CNS\n'}


{'id': 'HP_0025171', 'url': 'http://purl.obolibrary.org/obo/HP_0025171', 'lbl': 'Rosette-forming glioneuronal tumor', 'desc': 'label: Rosette-forming glioneuronal tumor\ndefinition : A tumor of the central nervous system that has components of both neurocytic and glial areas, whereby usually the glial component of the tumor predominates. Rossette-forming glioneuronal tumors (RGNT) have biphasic cytoarchitecture with two elements; neurocytic rosettes resembling Homer-Wright rosettes, and astrocytic component resembling a pilocytic astrocytoma. RGNTs are low-grade tumors that lack histopathological signs of malignancy.\nsynonyms :Rosette-forming glioneuronal neoplasm; Rosette-forming glioneuronal tumour; Rosette-forming glioneuronal tumor of the fourth ventricle; Rosette-forming glioneuronal tumour of the fourth ventricle\n'}


{'id': 'HP_0025172', 'url': 'http://purl.obolibrary.org/obo/HP_0025172', 'lbl': 'Smooth septal thickening on pulmonary HRCT', 'desc': 'label: Smooth septal thickening on pulmonary HRCT\ndefinition : Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with a smooth appearance of the interlobular septa.\nsynonyms :\n'}


{'id': 'HP_0025173', 'url': 'http://purl.obolibrary.org/obo/HP_0025173', 'lbl': 'Nodular septal thickening on pulmonary HRCT', 'desc': 'label: Nodular septal thickening on pulmonary HRCT\ndefinition : Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with a nodular or beaded appearance of the interlobular septa.\nsynonyms :\n'}


{'id': 'HP_0025174', 'url': 'http://purl.obolibrary.org/obo/HP_0025174', 'lbl': 'Irregular septal thickening on pulmonary HRCT', 'desc': 'label: Irregular septal thickening on pulmonary HRCT\ndefinition : Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with an irregular appearance of the interlobular septa. THis feature is often associated with distortion of lung architecture.\nsynonyms :\n'}


{'id': 'HP_0025175', 'url': 'http://purl.obolibrary.org/obo/HP_0025175', 'lbl': 'Honeycomb lung', 'desc': 'label: Honeycomb lung\ndefinition : Honeycombing represents destroyed and fibrotic lung tissue containing numerous cystic airspaces with thick fibrous walls, representing the late stage of various lung diseases, with complete loss of acinar architecture. The cysts range in size from a few millimeters to several centimeters in diameter, have variable wall thickness, and are lined by metaplastic bronchiolar epithelium. On chest radiographs, honeycombing appears as closely approximated ring shadows, typically 3-10 mm in diameter with walls 1-3 mm in thickness, that resemble a honeycomb; the finding implies end-stage lung disease. On CT scans, the appearance is of clustered cystic air spaces, typically of comparable diameters on the order of 3-10 mm but occasionally as large as 2.5 cm. Honeycombing is usually subpleural and is characterized by well-defined walls. It is a CT feature of established pulmonary fibrosis. Because honeycombing is often considered specific for pulmonary fibrosis and is an important criterion in the diagnosis of usual interstitial pneumonia, the term should be used with care, as it may directly impact patient care.\nsynonyms :Honeycomb cysts; Honeycombing\n'}


{'id': 'HP_0025176', 'url': 'http://purl.obolibrary.org/obo/HP_0025176', 'lbl': 'Intralobular interstitial thickening', 'desc': 'label: Intralobular interstitial thickening\ndefinition : A fine reticular pattern on high-resolution computed tomography, with the visible lines separated by a few millimeters. Regions of the lung with intralobular interstitial thickening characteristically show a fine lacelike or netlike appearance.\nsynonyms :\n'}


{'id': 'HP_0025177', 'url': 'http://purl.obolibrary.org/obo/HP_0025177', 'lbl': 'Peribronchovascular interstitial thickening', 'desc': 'label: Peribronchovascular interstitial thickening\ndefinition : Thickening of the peribronchovascular interstitium, a connective tissue sheath that surrounds the central bronchi and pulmonary arteries. The peribronchovascular interstitium extends from the level of the pulmonary hila into the peripheral lung. This feature may be ascertained on high-resolution computer tomography.\nsynonyms :\n'}


{'id': 'HP_0025178', 'url': 'http://purl.obolibrary.org/obo/HP_0025178', 'lbl': 'Subpleural interstitial thickening', 'desc': 'label: Subpleural interstitial thickening\ndefinition : Increase in thickness of the subpleural interstitium.\nsynonyms :Subpleural scarring\n'}


{'id': 'HP_0025179', 'url': 'http://purl.obolibrary.org/obo/HP_0025179', 'lbl': 'Ground-glass opacification', 'desc': 'label: Ground-glass opacification\ndefinition : On chest radiographs, ground-glass opacity appears as an area of hazy increased lung opacity, usually extensive, within which\nmargins of pulmonary vessels may be indistinct. On CT scans, it appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins. It is caused by partial filling of airspaces, interstitial thickening (due to fluid, cells, and/or fibrosis), partial collapse of alveoli, increased capillary blood volume, or a combination of these, the common factor being the partial displacement of air. Ground-glass opacity is less opaque than consolidation, in which bronchovascular margins are obscured.\nsynonyms :GGO; Ground glass opacities; Ground-glass opacification on pulmonary HRCT\n'}


{'id': 'HP_0025180', 'url': 'http://purl.obolibrary.org/obo/HP_0025180', 'lbl': 'Centrilobular ground-glass opacification on pulmonary HRCT', 'desc': 'label: Centrilobular ground-glass opacification on pulmonary HRCT\ndefinition : A hazy area of increased attenuation in centrilobular areas of the lung with preserved bronchial and vascular markings seen on a computer tomography scan. Centrilobular refers to a location that is central within secondary pulmonary lobules.\nsynonyms :Centrilobular groundglass opacification; Centrilobular groundglass opacity\n'}


{'id': 'HP_0025181', 'url': 'http://purl.obolibrary.org/obo/HP_0025181', 'lbl': 'Abdominal aseptic abscess', 'desc': 'label: Abdominal aseptic abscess\ndefinition : An abscess-like lesion located within the abdomen. The lesions are localized in the spleen, liver, abdominal lymph nodes. The lesions represent visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids, but relapses occur frequently.\nsynonyms :\n'}


{'id': 'HP_0025182', 'url': 'http://purl.obolibrary.org/obo/HP_0025182', 'lbl': 'Localized area of pendulous skin', 'desc': 'label: Localized area of pendulous skin\ndefinition : A confined region of lax skin that hangs below the level of the surrounding skin. Histopatholigically, there is a loss of elastic fibers in the dermis of the affected region.\nsynonyms :Localised area of pendulous skin\n'}