{'id': 'HP_0003546', 'url': 'http://purl.obolibrary.org/obo/HP_0003546', 'lbl': 'Exercise intolerance', 'desc': 'label: Exercise intolerance\ndefinition : A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender.\nsynonyms :Decreased ability to exercise; Inability to exercise; Low exercise endurance; Poor exercise tolerance\n'}


{'id': 'HP_0003547', 'url': 'http://purl.obolibrary.org/obo/HP_0003547', 'lbl': 'Shoulder girdle muscle weakness', 'desc': 'label: Shoulder girdle muscle weakness\ndefinition : The shoulder, or pectoral, girdle is composed of the clavicles and the scapulae. Shoulder-girdle weakness refers to lack of strength of the muscles attaching to these bones, that is, lack of strength of the muscles around the shoulders.\nsynonyms :Muscle weakness, shoulder-girdle; Shoulder girdle weakness; Shoulder weakness; Weak shoulder muscles\n'}


{'id': 'HP_0003548', 'url': 'http://purl.obolibrary.org/obo/HP_0003548', 'lbl': 'Subsarcolemmal accumulations of abnormally shaped mitochondria', 'desc': 'label: Subsarcolemmal accumulations of abnormally shaped mitochondria\ndefinition : An abnormally increased number of mitochondria in the cytoplasma adjacent to the sarcolemma (muscle cell membrane), whereby the mitochondria also possess an abnormal morphology.\nsynonyms :\n'}


{'id': 'HP_0003549', 'url': 'http://purl.obolibrary.org/obo/HP_0003549', 'lbl': 'Abnormality of connective tissue', 'desc': 'label: Abnormality of connective tissue\ndefinition : Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat).\nsynonyms :\n'}


{'id': 'HP_0003550', 'url': 'http://purl.obolibrary.org/obo/HP_0003550', 'lbl': 'Predominantly lower limb lymphedema', 'desc': 'label: Predominantly lower limb lymphedema\ndefinition : Localized fluid retention and tissue swelling caused by a compromised lymphatic system, affecting mainly the legs.\nsynonyms :\n'}


{'id': 'HP_0003551', 'url': 'http://purl.obolibrary.org/obo/HP_0003551', 'lbl': 'Difficulty climbing stairs', 'desc': 'label: Difficulty climbing stairs\ndefinition : Reduced ability to climb stairs.\nsynonyms :Difficulty walking up stairs\n'}


{'id': 'HP_0003552', 'url': 'http://purl.obolibrary.org/obo/HP_0003552', 'lbl': 'Muscle stiffness', 'desc': 'label: Muscle stiffness\ndefinition : A condition in which muscles cannot be moved quickly without accompanying pain or spasm.\nsynonyms :\n'}


{'id': 'HP_0003553', 'url': 'http://purl.obolibrary.org/obo/HP_0003553', 'lbl': 'obsolete Cellulitis due to immunodeficiency', 'desc': 'label: obsolete Cellulitis due to immunodeficiency\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003554', 'url': 'http://purl.obolibrary.org/obo/HP_0003554', 'lbl': 'Type 2 muscle fiber atrophy', 'desc': 'label: Type 2 muscle fiber atrophy\ndefinition : Atrophy (wasting) affecting primary type 2 muscle fibers. This feature in general can only be observed on muscle biopsy.\nsynonyms :Type 2 fiber atrophy; Type 2 fibre atrophy; Type 2 muscle fibre atrophy\n'}


{'id': 'HP_0003555', 'url': 'http://purl.obolibrary.org/obo/HP_0003555', 'lbl': 'Muscle fiber splitting', 'desc': 'label: Muscle fiber splitting\ndefinition : Fiber splitting or branching is a common finding in human and rat skeletal muscle pathology. Fiber splitting refers to longitudinal halving of the complete fiber, while branching originates from a regenerating end of a necrotic fiber as invaginations of the sarcolemma. In fiber branching, one end of the fiber remains intact as a single entity, while the other end has several branches.\nsynonyms :Fiber splitting; Fibre splitting; Muscle fibre splitting\n'}


{'id': 'HP_0003557', 'url': 'http://purl.obolibrary.org/obo/HP_0003557', 'lbl': 'Increased variability in muscle fiber diameter', 'desc': 'label: Increased variability in muscle fiber diameter\ndefinition : An abnormally high degree of muscle fiber size variation. This phenotypic feature can be observed upon muscle biopsy.\nsynonyms :Increased fiber size variation; Increased fibre size variation; Increased variability in muscle fiber size; Increased variability in muscle fibre diameter; Increased variability in muscle fibre size; Increased variation in fiber size; Increased variation in fibre size; Increased variation in muscle fiber size; Increased variation in muscle fibre size; Variation in muscle fiber size; Variation in muscle fibre size\n'}


{'id': 'HP_0003558', 'url': 'http://purl.obolibrary.org/obo/HP_0003558', 'lbl': 'Viral infection-induced rhabdomyolysis', 'desc': 'label: Viral infection-induced rhabdomyolysis\ndefinition : Rhabdomyolysis induced by a viral infection.\nsynonyms :\n'}


{'id': 'HP_0003559', 'url': 'http://purl.obolibrary.org/obo/HP_0003559', 'lbl': 'Muscle hyperirritability', 'desc': 'label: Muscle hyperirritability\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003560', 'url': 'http://purl.obolibrary.org/obo/HP_0003560', 'lbl': 'Muscular dystrophy', 'desc': 'label: Muscular dystrophy\ndefinition : The term dystrophy means abnormal growth. However, muscular dystrophy is used to describe primary myopathies with a genetic basis and a progressive course characterized by progressive skeletal muscle weakness and wasting, defects in muscle proteins, and histological features of muscle fiber degeneration (necrosis) and regeneration. If possible, it is preferred to use other HPO terms to describe the precise phenotypic abnormalities.\nsynonyms :Muscle biopsy shows dystrophic changes\n'}


{'id': 'HP_0003561', 'url': 'http://purl.obolibrary.org/obo/HP_0003561', 'lbl': 'Birth length less than 3rd percentile', 'desc': 'label: Birth length less than 3rd percentile\ndefinition : \nsynonyms :Birth length < 3rd percentile; Birth length <3rd percentile\n'}


{'id': 'HP_0003562', 'url': 'http://purl.obolibrary.org/obo/HP_0003562', 'lbl': 'Abnormal metaphyseal vascular invasion', 'desc': 'label: Abnormal metaphyseal vascular invasion\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003563', 'url': 'http://purl.obolibrary.org/obo/HP_0003563', 'lbl': 'Decreased LDL cholesterol concentration', 'desc': 'label: Decreased LDL cholesterol concentration\ndefinition : An decreased concentration of low-density lipoprotein cholesterol in the blood.\nsynonyms :Decreased LDLc concentration; Decreased circulating low-density lipoprotein levels; Hypobetalipoproteinemia; Decreased LDL\n'}


{'id': 'HP_0003564', 'url': 'http://purl.obolibrary.org/obo/HP_0003564', 'lbl': 'Folate-dependent fragile site at Xq28', 'desc': 'label: Folate-dependent fragile site at Xq28\ndefinition : The presence of a folate sensitive fragile site at chromosome Xq28.\nsynonyms :\n'}


{'id': 'HP_0003565', 'url': 'http://purl.obolibrary.org/obo/HP_0003565', 'lbl': 'Elevated erythrocyte sedimentation rate', 'desc': 'label: Elevated erythrocyte sedimentation rate\ndefinition : An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.\nsynonyms :Elevated ESR; Elevated sedimentation rate; High ESR; High erythrocyte sedimentation rate; Increased erythrocyte sedimentation rate; Raised erythrocyte sedimentation rate\n'}


{'id': 'HP_0003566', 'url': 'http://purl.obolibrary.org/obo/HP_0003566', 'lbl': 'Increased serum prostaglandin E2', 'desc': 'label: Increased serum prostaglandin E2\ndefinition : An increased concentration of prostaglandin E2 in the blood.\nsynonyms :Elevated prostaglandin E2\n'}


{'id': 'HP_0003568', 'url': 'http://purl.obolibrary.org/obo/HP_0003568', 'lbl': 'Decreased glucosephosphate isomerase level', 'desc': 'label: Decreased glucosephosphate isomerase level\ndefinition : A decreased level of glucose-6-phosphate isomerase.\nsynonyms :Decreased glucose phosphate isomerase activity; Glucosephosphate isomerase deficiency; Phosphohexose isomerase deficiency\n'}


{'id': 'HP_0003570', 'url': 'http://purl.obolibrary.org/obo/HP_0003570', 'lbl': 'Molybdenum cofactor deficiency', 'desc': 'label: Molybdenum cofactor deficiency\ndefinition : Absence of molybdenum cofactor(2-), a cofactor for enzymes including sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase.\nsynonyms :\n'}


{'id': 'HP_0003571', 'url': 'http://purl.obolibrary.org/obo/HP_0003571', 'lbl': 'Propionic acidemia', 'desc': 'label: Propionic acidemia\ndefinition : Increased concentration of proprionic acid in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0003572', 'url': 'http://purl.obolibrary.org/obo/HP_0003572', 'lbl': 'Low plasma citrulline', 'desc': 'label: Low plasma citrulline\ndefinition : A decreased concentration of citrulline in the blood.\nsynonyms :\n'}


{'id': 'HP_0003573', 'url': 'http://purl.obolibrary.org/obo/HP_0003573', 'lbl': 'Increased total bilirubin', 'desc': 'label: Increased total bilirubin\ndefinition : Increased concentration of total (conjugated and unconjugated) bilirubin in the blood.\nsynonyms :High bili total; Increased bilirubin\n'}


{'id': 'HP_0003574', 'url': 'http://purl.obolibrary.org/obo/HP_0003574', 'lbl': 'Positive regitine blocking test', 'desc': 'label: Positive regitine blocking test\ndefinition : A positive response to the regitine blocking test consisting of a substantial reduction in blood pressure following administration of regitine, indicative of the presence of increased levels of epinephrine and norepinephrine in the circulation, which is seen in pheochromocytoma-associated hypertension.\nsynonyms :\n'}


{'id': 'HP_0003575', 'url': 'http://purl.obolibrary.org/obo/HP_0003575', 'lbl': 'Increased intracellular sodium', 'desc': 'label: Increased intracellular sodium\ndefinition : An abnormally increased sodium concentration in the cytosol.\nsynonyms :High intracellular Na; Increased intracellular Na+ levels\n'}


{'id': 'HP_0003577', 'url': 'http://purl.obolibrary.org/obo/HP_0003577', 'lbl': 'Congenital onset', 'desc': 'label: Congenital onset\ndefinition : A phenotypic abnormality that is present at birth.\nsynonyms :Onset at birth; Symptoms present at birth\n'}


{'id': 'HP_0003581', 'url': 'http://purl.obolibrary.org/obo/HP_0003581', 'lbl': 'Adult onset', 'desc': 'label: Adult onset\ndefinition : Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later.\nsynonyms :Onset in adulthood; Onset in early adulthood; Symptoms begin in adulthood\n'}


{'id': 'HP_0003584', 'url': 'http://purl.obolibrary.org/obo/HP_0003584', 'lbl': 'Late onset', 'desc': 'label: Late onset\ndefinition : A type of adult onset with onset of symptoms after the age of 60 years.\nsynonyms :\n'}


{'id': 'HP_0003587', 'url': 'http://purl.obolibrary.org/obo/HP_0003587', 'lbl': 'Insidious onset', 'desc': 'label: Insidious onset\ndefinition : Gradual, very slow onset of disease manifestations.\nsynonyms :Gradual onset\n'}


{'id': 'HP_0003593', 'url': 'http://purl.obolibrary.org/obo/HP_0003593', 'lbl': 'Infantile onset', 'desc': 'label: Infantile onset\ndefinition : Onset of signs or symptoms of disease between 28 days to one year of life.\nsynonyms :Infantile onset; Onset in first year of life; Onset in infancy\n'}


{'id': 'HP_0003596', 'url': 'http://purl.obolibrary.org/obo/HP_0003596', 'lbl': 'Middle age onset', 'desc': 'label: Middle age onset\ndefinition : A type of adult onset with onset of symptoms at the age of 40 to 60 years.\nsynonyms :\n'}


{'id': 'HP_0003606', 'url': 'http://purl.obolibrary.org/obo/HP_0003606', 'lbl': 'Absent urinary urothione', 'desc': 'label: Absent urinary urothione\ndefinition : Lack of urothione (the urinary metabolite of molybdenum cofactor) in the urine.\nsynonyms :\n'}


{'id': 'HP_0003607', 'url': 'http://purl.obolibrary.org/obo/HP_0003607', 'lbl': '4-hydroxyphenylacetic aciduria', 'desc': 'label: 4-hydroxyphenylacetic aciduria\ndefinition : Increased concentration of 4-hydroxyphenylacetic acid in the urine.\nsynonyms :Elevated urine 4-hydroxyphenylacetic acid level\n'}


{'id': 'HP_0003609', 'url': 'http://purl.obolibrary.org/obo/HP_0003609', 'lbl': 'Foam cells with lamellar inclusion bodies', 'desc': 'label: Foam cells with lamellar inclusion bodies\ndefinition : The presence of foam cells that contain lamellar inclusion bodies.\nsynonyms :\n'}


{'id': 'HP_0003610', 'url': 'http://purl.obolibrary.org/obo/HP_0003610', 'lbl': 'Fibroblast metachromasia', 'desc': 'label: Fibroblast metachromasia\ndefinition : Increased cytoplasmic staining of fibroblasts with toluidine blue.\nsynonyms :\n'}


{'id': 'HP_0003612', 'url': 'http://purl.obolibrary.org/obo/HP_0003612', 'lbl': 'Positive ferric chloride test', 'desc': 'label: Positive ferric chloride test\ndefinition : If positive, the ferric chloride test indicates an increased concentration of phenols in the urine or blood.\nsynonyms :Positive FeCl3 test\n'}


{'id': 'HP_0003613', 'url': 'http://purl.obolibrary.org/obo/HP_0003613', 'lbl': 'Antiphospholipid antibody positivity', 'desc': 'label: Antiphospholipid antibody positivity\ndefinition : The presence of circulating autoantibodies to phospholipids.\nsynonyms :Antiphospholipid antibodies; Antiphospholipid antibody; Phospholipid antibody positivity\n'}


{'id': 'HP_0003614', 'url': 'http://purl.obolibrary.org/obo/HP_0003614', 'lbl': 'Trimethylaminuria', 'desc': 'label: Trimethylaminuria\ndefinition : Increased concentration of trimethylamine in the urine.\nsynonyms :High urine trimethylamine levels\n'}


{'id': 'HP_0003616', 'url': 'http://purl.obolibrary.org/obo/HP_0003616', 'lbl': 'Premature separation of centromeric heterochromatin', 'desc': 'label: Premature separation of centromeric heterochromatin\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003621', 'url': 'http://purl.obolibrary.org/obo/HP_0003621', 'lbl': 'Juvenile onset', 'desc': 'label: Juvenile onset\ndefinition : Onset of signs or symptoms of disease between the age of 5 and 15 years.\nsynonyms :Signs and symptoms begin before 15 years of age\n'}


{'id': 'HP_0003623', 'url': 'http://purl.obolibrary.org/obo/HP_0003623', 'lbl': 'Neonatal onset', 'desc': 'label: Neonatal onset\ndefinition : Onset of signs or symptoms of disease within the first 28 days of life.\nsynonyms :Neonatal onset; Onset in first weeks of life; Onset in neonatal period\n'}


{'id': 'HP_0003634', 'url': 'http://purl.obolibrary.org/obo/HP_0003634', 'lbl': 'Amyoplasia', 'desc': 'label: Amyoplasia\ndefinition : Congenital lack of development of the muscles, which are then replaced by a mixture of dense fat and fibrous tissue.\nsynonyms :Absent muscles since birth; Congenital absence of muscles\n'}


{'id': 'HP_0003635', 'url': 'http://purl.obolibrary.org/obo/HP_0003635', 'lbl': 'Loss of subcutaneous adipose tissue in limbs', 'desc': 'label: Loss of subcutaneous adipose tissue in limbs\ndefinition : Loss (disappearance) of previously present subcutaneous fat tissue in arm or leg.\nsynonyms :Loss of fat tissue below the skin in limbs; Loss of subcutaneous adipose tissue from extremities\n'}


{'id': 'HP_0003637', 'url': 'http://purl.obolibrary.org/obo/HP_0003637', 'lbl': 'Reduced 4-Hydroxyphenylpyruvate dioxygenase level', 'desc': 'label: Reduced 4-Hydroxyphenylpyruvate dioxygenase level\ndefinition : An abnormal reduction in 4-hydroxyphenylpyruvate dioxygenase level.\nsynonyms :Reducted HPPD activity\n'}


{'id': 'HP_0003639', 'url': 'http://purl.obolibrary.org/obo/HP_0003639', 'lbl': 'Elevated urinary epinephrine', 'desc': 'label: Elevated urinary epinephrine\ndefinition : An increased concentration of adrenaline in the urine.\nsynonyms :Increased urinary epinephrine\n'}


{'id': 'HP_0003640', 'url': 'http://purl.obolibrary.org/obo/HP_0003640', 'lbl': 'CNS foam cells', 'desc': 'label: CNS foam cells\ndefinition : The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, in the central nervous system.\nsynonyms :\n'}


{'id': 'HP_0003641', 'url': 'http://purl.obolibrary.org/obo/HP_0003641', 'lbl': 'Hemoglobinuria', 'desc': 'label: Hemoglobinuria\ndefinition : The presence of free hemoglobin in the urine.\nsynonyms :Haemoglobin in urine; Hemoglobin in urine\n'}


{'id': 'HP_0003642', 'url': 'http://purl.obolibrary.org/obo/HP_0003642', 'lbl': 'Type I transferrin isoform profile', 'desc': 'label: Type I transferrin isoform profile\ndefinition : Abnormal transferrin isoform profile consistent with a type I congenital disorder of glycosylation. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II.\nsynonyms :Abnormal isoelectric focusing of serum transferrin, type I pattern; Isoelectric focusing of serum transferrin consistent with CDG type I; Type 1 transferrin isoform profile\n'}


{'id': 'HP_0003643', 'url': 'http://purl.obolibrary.org/obo/HP_0003643', 'lbl': 'Sulfite oxidase deficiency', 'desc': 'label: Sulfite oxidase deficiency\ndefinition : Abnormally reduced sulfite oxidase level.\nsynonyms :\n'}


{'id': 'HP_0003645', 'url': 'http://purl.obolibrary.org/obo/HP_0003645', 'lbl': 'Prolonged partial thromboplastin time', 'desc': 'label: Prolonged partial thromboplastin time\ndefinition : Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure of the intrinsic and common coagulation pathways. Phospholipid, and activator, and calcium are mixed into an anticoagulated plasma sample, and the time is measured until a thrombus forms.\nsynonyms :Abnormal partial thromboplastin time; Delayed thromboplastin generation; Partial thromboplastin time prolonged; Prolonged PTT; Prolonged activated partial thromboplastin time\n'}


{'id': 'HP_0003646', 'url': 'http://purl.obolibrary.org/obo/HP_0003646', 'lbl': 'Bicarbonaturia', 'desc': 'label: Bicarbonaturia\ndefinition : Abnormally increased concentration of hydrogencarbonate in the urine.\nsynonyms :Increased urine HCO3 concentration; Increased urine bicarbonate concentration\n'}


{'id': 'HP_0003647', 'url': 'http://purl.obolibrary.org/obo/HP_0003647', 'lbl': 'Electron transfer flavoprotein-ubiquinone oxidoreductase defect', 'desc': 'label: Electron transfer flavoprotein-ubiquinone oxidoreductase defect\ndefinition : A deficiency of the electron transfer flavoprotein-ubiquinone oxidoreductase.\nsynonyms :\n'}


{'id': 'HP_0003648', 'url': 'http://purl.obolibrary.org/obo/HP_0003648', 'lbl': 'Lacticaciduria', 'desc': 'label: Lacticaciduria\ndefinition : An increased concentration of lactic acid in the urine.\nsynonyms :High urine lactic acid levels; Increased urine lactate\n'}


{'id': 'HP_0003649', 'url': 'http://purl.obolibrary.org/obo/HP_0003649', 'lbl': 'Abnormality of glycoside metabolism', 'desc': 'label: Abnormality of glycoside metabolism\ndefinition : Abnormality of glycoside metabolism.\nsynonyms :\n'}


{'id': 'HP_0003651', 'url': 'http://purl.obolibrary.org/obo/HP_0003651', 'lbl': 'Foam cells', 'desc': 'label: Foam cells\ndefinition : The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.\nsynonyms :Foamy histiocytes; Foamy macrophages; Lipid-laden histiocytes; Presence of foam cells\n'}


{'id': 'HP_0003652', 'url': 'http://purl.obolibrary.org/obo/HP_0003652', 'lbl': 'Recurrent myoglobinuria', 'desc': 'label: Recurrent myoglobinuria\ndefinition : Recurring episodes of myoglobinuria, i.e., of the presence of myoglobin in the urine. This is usually a consequence of rhabdomyolysis, i.e., of the destruction of muscle tissue.\nsynonyms :Myoglobinuria, episodic; Myoglobinuria, recurrent\n'}


{'id': 'HP_0003653', 'url': 'http://purl.obolibrary.org/obo/HP_0003653', 'lbl': 'Cellular metachromasia', 'desc': 'label: Cellular metachromasia\ndefinition : Metachromasia (also known as metachromacy) is a characteristic color change which certain aniline dyes exhibit when bound to particular substances or when concentrated in solution. For example, the basic dye toluidine blue becomes distinctly pink when bound to cartilage matrix. In the sense used here, the metachromasia refers to a change in color not observed with normal tissues, anomalous staining with the cationic dyes toluidine blue O and Alcian blue resulting from excessive amounts of the polyanionic glycosaminoglycans.\nsynonyms :\n'}


{'id': 'HP_0003654', 'url': 'http://purl.obolibrary.org/obo/HP_0003654', 'lbl': 'Reduced dihydropyrimidine dehydrogenase level', 'desc': 'label: Reduced dihydropyrimidine dehydrogenase level\ndefinition : An abnormal reduction in dihydropyrimidine dehydrogenase (NADP+) level.\nsynonyms :Dihydropyrimidine dehydrogenase deficiency\n'}


{'id': 'HP_0003655', 'url': 'http://purl.obolibrary.org/obo/HP_0003655', 'lbl': 'Reduced level of N-acetylglucosaminyltransferase II', 'desc': 'label: Reduced level of N-acetylglucosaminyltransferase II\ndefinition : An abnormality of glycoprotein metabolism related to a decreased level of alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity.\nsynonyms :Deficient N-acetylglucosaminyltransferase II\n'}


{'id': 'HP_0003656', 'url': 'http://purl.obolibrary.org/obo/HP_0003656', 'lbl': 'Decreased beta-glucocerebrosidase level', 'desc': 'label: Decreased beta-glucocerebrosidase level\ndefinition : Reduced level of the enzyme beta-glucosidase, an enzyme that catalyzes the hydrolysis of glucosylceramide into ceramide and glucose.\nsynonyms :Decreased lysosomal acid glucosylceramidase activity\n'}


{'id': 'HP_0003657', 'url': 'http://purl.obolibrary.org/obo/HP_0003657', 'lbl': 'Vascular granular osmiophilic material deposition', 'desc': 'label: Vascular granular osmiophilic material deposition\ndefinition : Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide. Deposition of granular osmiophilic material (GOM) is the vascular pathological hallmark of CADASIL, which is the most prevalent hereditary small vessel disease and is caused by missense mutations in the NOTCH3 gene. GOM have been shown to contain NOTCH3 ectodomain (NOTCH3ECD) and extracellular matrix proteins, and can be visualized ultrastructurally in the tunica media of small arteries and capillaries. These electron dense GOM deposits are located in the basement membrane of mural cells, i.e. vascular smooth muscle cells and pericytes. In both manifest and pre-manifest CADASIL patients, GOM deposits are present not only in brain vessels, but also in vessels of other organs, such as the skin.\nsynonyms :Granular osmiophilic deposits (GROD) in cells\n'}


{'id': 'HP_0003658', 'url': 'http://purl.obolibrary.org/obo/HP_0003658', 'lbl': 'Hypomethioninemia', 'desc': 'label: Hypomethioninemia\ndefinition : A decreased concentration of methionine in the blood.\nsynonyms :Decreased plasma methionine; Decreased serum methionine\n'}


{'id': 'HP_0003665', 'url': 'http://purl.obolibrary.org/obo/HP_0003665', 'lbl': 'Amyotrophy of the musculature of the pelvis', 'desc': 'label: Amyotrophy of the musculature of the pelvis\ndefinition : Muscular atrophy affecting the muscles of the pelvis.\nsynonyms :\n'}


{'id': 'HP_0003674', 'url': 'http://purl.obolibrary.org/obo/HP_0003674', 'lbl': 'Onset', 'desc': 'label: Onset\ndefinition : The age group in which disease manifestations appear.\nsynonyms :Age of onset; Age symptoms begin\n'}


{'id': 'HP_0003676', 'url': 'http://purl.obolibrary.org/obo/HP_0003676', 'lbl': 'Progressive', 'desc': 'label: Progressive\ndefinition : Applies to a disease manifestation that increases in scope or severity over the course of time, i.e., that worsens with age.\nsynonyms :Worsens with time; Progressive disorder\n'}


{'id': 'HP_0003677', 'url': 'http://purl.obolibrary.org/obo/HP_0003677', 'lbl': 'Slowly progressive', 'desc': 'label: Slowly progressive\ndefinition : Applies to a disease manifestation that only slowly increases in scope or severity over the course of time.\nsynonyms :Signs and symptoms worsen slowly with time; Slow disease progression; Slow progression; Slowly progressive disorder\n'}


{'id': 'HP_0003678', 'url': 'http://purl.obolibrary.org/obo/HP_0003678', 'lbl': 'Rapidly progressive', 'desc': 'label: Rapidly progressive\ndefinition : Applies to a disease manifestation that quickly increases in scope or severity over the course of time.\nsynonyms :Rapid progression; Worsening quickly; Rapidly progressive disorder\n'}


{'id': 'HP_0003679', 'url': 'http://purl.obolibrary.org/obo/HP_0003679', 'lbl': 'Pace of progression', 'desc': 'label: Pace of progression\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003680', 'url': 'http://purl.obolibrary.org/obo/HP_0003680', 'lbl': 'Nonprogressive', 'desc': 'label: Nonprogressive\ndefinition : Applies to a disease manifestation that does not increase in scope or severity over the course of time, i.e., that does not worsen with age.\nsynonyms :Does not worsen; Non-progressive; Nonprogressive course; Nonprogressive disorder; Stationary\n'}


{'id': 'HP_0003682', 'url': 'http://purl.obolibrary.org/obo/HP_0003682', 'lbl': 'Variable progression rate', 'desc': 'label: Variable progression rate\ndefinition : Applies to a disease manifestation that quickly increases in scope or severity with a rate that varies. For instance, progression may be slow in one time period and rapid in another.\nsynonyms :\n'}


{'id': 'HP_0003683', 'url': 'http://purl.obolibrary.org/obo/HP_0003683', 'lbl': 'obsolete Large beaked nose', 'desc': 'label: obsolete Large beaked nose\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003687', 'url': 'http://purl.obolibrary.org/obo/HP_0003687', 'lbl': 'Centrally nucleated skeletal muscle fibers', 'desc': 'label: Centrally nucleated skeletal muscle fibers\ndefinition : An abnormality in which the nuclei of sarcomeres take on an abnormally central localization (or in which this feature is found in an increased proportion of muscle cells).\nsynonyms :Central nuclei; Centralised nuclei; Centralised sarcomeric nuclei; Centralized nuclei; Centralized sarcomeric nuclei; Centrally nucleated skeletal muscle fibres\n'}


{'id': 'HP_0003688', 'url': 'http://purl.obolibrary.org/obo/HP_0003688', 'lbl': 'Cytochrome C oxidase-negative muscle fibers', 'desc': 'label: Cytochrome C oxidase-negative muscle fibers\ndefinition : An abnormally reduced activity of the enzyme cytochrome C oxidase in muscle tissue.\nsynonyms :Cytochrome C oxidase-negative muscle fibres; Cytochrome c oxidase deficiency in skeletal muscle; Decreased activity of cytochrome C oxidase in muscle tissue; Decreased skeletal muscle cytochrome c oxidase activity\n'}


{'id': 'HP_0003689', 'url': 'http://purl.obolibrary.org/obo/HP_0003689', 'lbl': 'Multiple mitochondrial DNA deletions', 'desc': 'label: Multiple mitochondrial DNA deletions\ndefinition : The presence of multiple deletions of mitochondrial DNA (mtDNA).\nsynonyms :Multiple mtDNA deletions\n'}


{'id': 'HP_0003690', 'url': 'http://purl.obolibrary.org/obo/HP_0003690', 'lbl': 'Limb muscle weakness', 'desc': 'label: Limb muscle weakness\ndefinition : Reduced strength and weakness of the muscles of the arms and legs.\nsynonyms :Limb muscle weakness; Limb weakness\n'}


{'id': 'HP_0003691', 'url': 'http://purl.obolibrary.org/obo/HP_0003691', 'lbl': 'Scapular winging', 'desc': 'label: Scapular winging\ndefinition : Abnormal protrusion of the scapula away from the surface of the back.\nsynonyms :Scapula alata; Winged scapulae; Winged scapulas; Winged shoulder blade; Scapular weakness\n'}


{'id': 'HP_0003693', 'url': 'http://purl.obolibrary.org/obo/HP_0003693', 'lbl': 'Distal amyotrophy', 'desc': 'label: Distal amyotrophy\ndefinition : Muscular atrophy affecting muscles in the distal portions of the extremities.\nsynonyms :Amyotrophy of distal limb muscles; Distal amyotrophy, especially of the hands and feet; Distal limb muscle atrophy; Distal muscle atrophy; Distal muscle atrophy, upper and lower limbs; Distal muscle degeneration; Distal muscle wasting; Distal muscular atrophy; Muscle atrophy, distal\n'}


{'id': 'HP_0003694', 'url': 'http://purl.obolibrary.org/obo/HP_0003694', 'lbl': 'Late-onset proximal muscle weakness', 'desc': 'label: Late-onset proximal muscle weakness\ndefinition : Lack of strength of the proximal musculature occurring late in the clinical course.\nsynonyms :\n'}


{'id': 'HP_0003696', 'url': 'http://purl.obolibrary.org/obo/HP_0003696', 'lbl': 'Absent epiphysis of the distal phalanx of the 5th finger', 'desc': 'label: Absent epiphysis of the distal phalanx of the 5th finger\ndefinition : Absence of the epiphysis located at the proximal end of the distal phalanx of the 5th finger.\nsynonyms :Absent end part of the outermost bone of the little finger; Absent end part of the outermost bone of the pinkie finger; Absent end part of the outermost bone of the pinky finger\n'}


{'id': 'HP_0003697', 'url': 'http://purl.obolibrary.org/obo/HP_0003697', 'lbl': 'Scapuloperoneal amyotrophy', 'desc': 'label: Scapuloperoneal amyotrophy\ndefinition : Muscular atrophy in the distribution of shoulder girdle and peroneal muscles.\nsynonyms :Scapuloperoneal atrophy\n'}


{'id': 'HP_0003698', 'url': 'http://purl.obolibrary.org/obo/HP_0003698', 'lbl': 'Difficulty standing', 'desc': 'label: Difficulty standing\ndefinition : \nsynonyms :Difficulty in standing; Standing instability\n'}


{'id': 'HP_0003700', 'url': 'http://purl.obolibrary.org/obo/HP_0003700', 'lbl': 'Generalized amyotrophy', 'desc': 'label: Generalized amyotrophy\ndefinition : Generalized (diffuse, unlocalized) amyotrophy (muscle atrophy) affecting multiple muscles.\nsynonyms :Diffuse amyotrophy; Diffuse muscle atrophy; Diffuse muscle wasting; Diffuse skeletal muscle wasting; Generalised amyotrophy; Generalised muscle atrophy; Generalised muscle degeneration; Generalized muscle atrophy; Generalized muscle degeneration; Muscle atrophy, diffuse; Muscle atrophy, generalised; Muscle atrophy, generalized; Muscular atrophy, generalised; Muscular atrophy, generalized\n'}


{'id': 'HP_0003701', 'url': 'http://purl.obolibrary.org/obo/HP_0003701', 'lbl': 'Proximal muscle weakness', 'desc': 'label: Proximal muscle weakness\ndefinition : A lack of strength of the proximal muscles.\nsynonyms :Muscle weakness, proximal; Proximal limb muscle weakness; Proximal limb weakness; Weakness in muscles of upper arms and upper legs; Proximal neurogenic muscle weakness\n'}


{'id': 'HP_0003704', 'url': 'http://purl.obolibrary.org/obo/HP_0003704', 'lbl': 'Scapuloperoneal weakness', 'desc': 'label: Scapuloperoneal weakness\ndefinition : \nsynonyms :Neurogenic scapuloperoneal syndrome\n'}


{'id': 'HP_0003707', 'url': 'http://purl.obolibrary.org/obo/HP_0003707', 'lbl': 'Calf muscle pseudohypertrophy', 'desc': 'label: Calf muscle pseudohypertrophy\ndefinition : Enlargement of the muscles of the calf due to their replacement by connective tissue or fat.\nsynonyms :Pseudohypertrophy of the calves\n'}


{'id': 'HP_0003710', 'url': 'http://purl.obolibrary.org/obo/HP_0003710', 'lbl': 'Exercise-induced muscle cramps', 'desc': 'label: Exercise-induced muscle cramps\ndefinition : Sudden and involuntary contractions of one or more muscles brought on by physical exertion.\nsynonyms :Exercise-induced muscle cramping; Exercise-induced muscle cramps; Muscle cramps following exercise; Muscle cramps on exercise; Muscle cramps on exertion; Muscle cramps with exertion\n'}


{'id': 'HP_0003712', 'url': 'http://purl.obolibrary.org/obo/HP_0003712', 'lbl': 'Skeletal muscle hypertrophy', 'desc': 'label: Skeletal muscle hypertrophy\ndefinition : Abnormal increase in muscle size and mass not due to training.\nsynonyms :Hypertrophic muscles; Increased skeletal muscle cells; Muscle hypertrophy; Muscular hypertrophy\n'}


{'id': 'HP_0003713', 'url': 'http://purl.obolibrary.org/obo/HP_0003713', 'lbl': 'Muscle fiber necrosis', 'desc': 'label: Muscle fiber necrosis\ndefinition : Abnormal cell death involving muscle fibers usually associated with break in, or absence of, muscle surface fiber membrane and resulting in irreversible damage to muscle fibers.\nsynonyms :Muscle fibre necrosis\n'}


{'id': 'HP_0003715', 'url': 'http://purl.obolibrary.org/obo/HP_0003715', 'lbl': 'Myofibrillar myopathy', 'desc': 'label: Myofibrillar myopathy\ndefinition : Myofibrillar structural changes characterized by abnormal intracellular accumulation of the intermediate filament desmin and other proteins.\nsynonyms :Myofibrillar changes\n'}


{'id': 'HP_0003716', 'url': 'http://purl.obolibrary.org/obo/HP_0003716', 'lbl': 'Generalized muscular appearance from birth', 'desc': 'label: Generalized muscular appearance from birth\ndefinition : \nsynonyms :Generalised muscular appearance from birth\n'}


{'id': 'HP_0003717', 'url': 'http://purl.obolibrary.org/obo/HP_0003717', 'lbl': 'Minimal subcutaneous fat', 'desc': 'label: Minimal subcutaneous fat\ndefinition : \nsynonyms :Minimal fat below the skin\n'}


{'id': 'HP_0003719', 'url': 'http://purl.obolibrary.org/obo/HP_0003719', 'lbl': 'Muscle mounding', 'desc': 'label: Muscle mounding\ndefinition : Percussion-induced, local prolonged contractions (mounding) in muscle persisting for several seconds.\nsynonyms :\n'}


{'id': 'HP_0003720', 'url': 'http://purl.obolibrary.org/obo/HP_0003720', 'lbl': 'Generalized muscle hypertrophy', 'desc': 'label: Generalized muscle hypertrophy\ndefinition : Hypertrophy (increase in size) of muscle tissue in a generalized (not localized) distribution.\nsynonyms :Generalised increase in muscle cell size; Generalised muscle hypertrophy; Generalized increase in muscle cell size\n'}


{'id': 'HP_0003722', 'url': 'http://purl.obolibrary.org/obo/HP_0003722', 'lbl': 'Neck flexor weakness', 'desc': 'label: Neck flexor weakness\ndefinition : Weakness of the muscles involved in neck flexion (sternocleidomastoid, longus capitus, longus colli, and scalenus anterior).\nsynonyms :Neck flexion weakness; Neck flexor muscle weakness\n'}


{'id': 'HP_0003724', 'url': 'http://purl.obolibrary.org/obo/HP_0003724', 'lbl': 'Shoulder girdle muscle atrophy', 'desc': 'label: Shoulder girdle muscle atrophy\ndefinition : Amyotrophy affecting the muscles of the shoulder girdle.\nsynonyms :Shoulder girdle atrophy; Shoulder girdle muscle wasting; Shoulder-girdle muscle atrophy\n'}


{'id': 'HP_0003725', 'url': 'http://purl.obolibrary.org/obo/HP_0003725', 'lbl': 'Firm muscles', 'desc': 'label: Firm muscles\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003729', 'url': 'http://purl.obolibrary.org/obo/HP_0003729', 'lbl': 'Enteroviral dermatomyositis syndrome', 'desc': 'label: Enteroviral dermatomyositis syndrome\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003730', 'url': 'http://purl.obolibrary.org/obo/HP_0003730', 'lbl': 'EMG: myotonic runs', 'desc': 'label: EMG: myotonic runs\ndefinition : Spontaneous, repetitive electrical activity demonstrated by electromyography (EMG).\nsynonyms :EMG: spontaneous, repetitive electrical activity\n'}


{'id': 'HP_0003731', 'url': 'http://purl.obolibrary.org/obo/HP_0003731', 'lbl': 'Quadriceps muscle weakness', 'desc': 'label: Quadriceps muscle weakness\ndefinition : Weakness of the quadriceps muscle (that is, of the muscle fasciculus of quadriceps femoris).\nsynonyms :Quadriceps weakness\n'}


{'id': 'HP_0003733', 'url': 'http://purl.obolibrary.org/obo/HP_0003733', 'lbl': 'Thigh hypertrophy', 'desc': 'label: Thigh hypertrophy\ndefinition : Muscle hypertrophy affecting the thighs.\nsynonyms :Increased thigh size\n'}


{'id': 'HP_0003736', 'url': 'http://purl.obolibrary.org/obo/HP_0003736', 'lbl': 'Autophagic vacuoles', 'desc': 'label: Autophagic vacuoles\ndefinition : The lysosomal-vacuolar pathway has a role in the controlled intracellular digestion of macromolecules such as protein complexes and organelles. This feature refers to the presence of an abnormally increased number of autophagic vacuoles in muscle tissue.\nsynonyms :\n'}


{'id': 'HP_0003737', 'url': 'http://purl.obolibrary.org/obo/HP_0003737', 'lbl': 'Mitochondrial myopathy', 'desc': 'label: Mitochondrial myopathy\ndefinition : A type of myopathy associated with mitochondrial disease and characterized by findings on biopsy such as ragged red muscle fibers.\nsynonyms :\n'}


{'id': 'HP_0003738', 'url': 'http://purl.obolibrary.org/obo/HP_0003738', 'lbl': 'Exercise-induced myalgia', 'desc': 'label: Exercise-induced myalgia\ndefinition : The occurrence of an unusually high amount of muscle pain following exercise.\nsynonyms :Exercise-induced muscle pain; Muscle pain on exercise; Muscle pain with exercise; Muscle pain, exercise-induced\n'}


{'id': 'HP_0003739', 'url': 'http://purl.obolibrary.org/obo/HP_0003739', 'lbl': 'Myoclonic spasms', 'desc': 'label: Myoclonic spasms\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003740', 'url': 'http://purl.obolibrary.org/obo/HP_0003740', 'lbl': 'Myotonia with warm-up phenomenon', 'desc': 'label: Myotonia with warm-up phenomenon\ndefinition : Myotonia that occurs after a period of rest and decreases with continuing exercise.\nsynonyms :\n'}


{'id': 'HP_0003741', 'url': 'http://purl.obolibrary.org/obo/HP_0003741', 'lbl': 'Congenital muscular dystrophy', 'desc': 'label: Congenital muscular dystrophy\ndefinition : \nsynonyms :Muscular dystrophy, congenital\n'}


{'id': 'HP_0003743', 'url': 'http://purl.obolibrary.org/obo/HP_0003743', 'lbl': 'Genetic anticipation', 'desc': 'label: Genetic anticipation\ndefinition : A type of autosomal dominant inheritance involving a gene that exhibits anticipation, the increase in severity and/or an earlier age of onset in subsequent generations.\nsynonyms :Autosomal dominant with genetic anticipation\n'}


{'id': 'HP_0003744', 'url': 'http://purl.obolibrary.org/obo/HP_0003744', 'lbl': 'Genetic anticipation with paternal anticipation bias', 'desc': 'label: Genetic anticipation with paternal anticipation bias\ndefinition : A type of genetic anticipation observed predominantly upon transmission from affected males.\nsynonyms :Paternal anticipation bias\n'}


{'id': 'HP_0003745', 'url': 'http://purl.obolibrary.org/obo/HP_0003745', 'lbl': 'Sporadic', 'desc': 'label: Sporadic\ndefinition : Cases of the disease in question occur without a previous family history, i.e., as isolated cases without being transmitted from a parent and without other siblings being affected.\nsynonyms :Isolated cases; No previous family history\n'}


{'id': 'HP_0003749', 'url': 'http://purl.obolibrary.org/obo/HP_0003749', 'lbl': 'Pelvic girdle muscle weakness', 'desc': 'label: Pelvic girdle muscle weakness\ndefinition : Weakness of the muscles of the pelvic girdle (also known as the hip girdle), that is, lack of strength of the muscles around the pelvis.\nsynonyms :Hip girdle muscle weakness; Hip girdle weakness; Hip-girdle muscle weakness; Pelvic girdle weakness\n'}


{'id': 'HP_0003750', 'url': 'http://purl.obolibrary.org/obo/HP_0003750', 'lbl': 'Increased muscle fatiguability', 'desc': 'label: Increased muscle fatiguability\ndefinition : An abnormal, increased fatiguability of the musculature.\nsynonyms :Muscle fatigue\n'}


{'id': 'HP_0003752', 'url': 'http://purl.obolibrary.org/obo/HP_0003752', 'lbl': 'Episodic flaccid weakness', 'desc': 'label: Episodic flaccid weakness\ndefinition : Recurrent episodes of muscle flaccidity, a type of paralysis in which a muscle becomes soft and yields to passive stretching.\nsynonyms :\n'}


{'id': 'HP_0003755', 'url': 'http://purl.obolibrary.org/obo/HP_0003755', 'lbl': 'Type 1 fibers relatively smaller than type 2 fibers', 'desc': 'label: Type 1 fibers relatively smaller than type 2 fibers\ndefinition : The presence of abnormal muscle fiber size such that type 1 fibers are smaller than type 2 fibers.\nsynonyms :Type 1 fibres relatively smaller than type 2 fibres\n'}


{'id': 'HP_0003756', 'url': 'http://purl.obolibrary.org/obo/HP_0003756', 'lbl': 'Skeletal myopathy', 'desc': 'label: Skeletal myopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003758', 'url': 'http://purl.obolibrary.org/obo/HP_0003758', 'lbl': 'Reduced subcutaneous adipose tissue', 'desc': 'label: Reduced subcutaneous adipose tissue\ndefinition : A reduced amount of fat tissue in the lowest layer of the integument. This feature can be appreciated by a reduced skinfold thickness.\nsynonyms :Decreased subcutaneous adipose tissue; Decreased subcutaneous fat; Reduced fat tissue below the skin; Reduced subcutaneous fat; Scanty adipose tissue\n'}


{'id': 'HP_0003759', 'url': 'http://purl.obolibrary.org/obo/HP_0003759', 'lbl': 'Hypoplasia of lymphatic vessels', 'desc': 'label: Hypoplasia of lymphatic vessels\ndefinition : Congenital underdevelopment of lymph vessels.\nsynonyms :Underdeveloped lymphatic vessels\n'}


{'id': 'HP_0003760', 'url': 'http://purl.obolibrary.org/obo/HP_0003760', 'lbl': 'Percussion-induced rapid rolling muscle contractions', 'desc': 'label: Percussion-induced rapid rolling muscle contractions\ndefinition : Mechanical percussion (i.e., striking a muscle with a reflex hammer) leads to spreading waves of muscle contractions that begin proximally and spread laterally across the muscle.\nsynonyms :\n'}


{'id': 'HP_0003761', 'url': 'http://purl.obolibrary.org/obo/HP_0003761', 'lbl': 'Calcinosis', 'desc': 'label: Calcinosis\ndefinition : Formation of calcium deposits in any soft tissue.\nsynonyms :Calcium buildup in soft tissues of body\n'}


{'id': 'HP_0003762', 'url': 'http://purl.obolibrary.org/obo/HP_0003762', 'lbl': 'Uterus didelphys', 'desc': 'label: Uterus didelphys\ndefinition : A malformation of the uterus in which the uterus is present as a paired organ as a result of the failure of fusion of the mullerian ducts during embryogenesis.\nsynonyms :Double uterus\n'}


{'id': 'HP_0003763', 'url': 'http://purl.obolibrary.org/obo/HP_0003763', 'lbl': 'Bruxism', 'desc': 'label: Bruxism\ndefinition : Bruxism is characterized by the grinding of the teeth including the clenching of the jaw and typically occur during sleep, but also can occur while the affected individual is awake.\nsynonyms :Teeth grinding\n'}


{'id': 'HP_0003764', 'url': 'http://purl.obolibrary.org/obo/HP_0003764', 'lbl': 'Nevus', 'desc': 'label: Nevus\ndefinition : A nevus is a type of hamartoma that is a circumscribed stable malformation of the skin.\nsynonyms :Mole; Naevus; Naevi; Nevi\n'}


{'id': 'HP_0003765', 'url': 'http://purl.obolibrary.org/obo/HP_0003765', 'lbl': 'Psoriasiform dermatitis', 'desc': 'label: Psoriasiform dermatitis\ndefinition : A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales).\nsynonyms :Psoriasis\n'}


{'id': 'HP_0003768', 'url': 'http://purl.obolibrary.org/obo/HP_0003768', 'lbl': 'Periodic paralysis', 'desc': 'label: Periodic paralysis\ndefinition : Episodes of muscle weakness.\nsynonyms :Episodic paralysis\n'}


{'id': 'HP_0003771', 'url': 'http://purl.obolibrary.org/obo/HP_0003771', 'lbl': 'Pulp calcification', 'desc': 'label: Pulp calcification\ndefinition : Pulp calcifications may appear as punctate calcifications, irregular, roughly spherical mineralized masses in any part of the pulp. It may occur isolated or associated to calcifications elsewhere such as the carotid arteries and kidneys. The diagnosis pulp calcifications can be established using radiological studies.\nsynonyms :Pulp calcifications; Pulp denticles; Pulp stones; Pulpoliths; False denticles; False pulp stones; True denticles; True pulp stones\n'}


{'id': 'HP_0003774', 'url': 'http://purl.obolibrary.org/obo/HP_0003774', 'lbl': 'Stage 5 chronic kidney disease', 'desc': 'label: Stage 5 chronic kidney disease\ndefinition : A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine.\nsynonyms :Chronic renal failure; End stage renal disease; End stage renal failure; End-stage renal disease; End-stage renal failure; Stage 5 chronic kidney disease; Renal failure, endstage\n'}


{'id': 'HP_0003777', 'url': 'http://purl.obolibrary.org/obo/HP_0003777', 'lbl': 'Pili torti', 'desc': 'label: Pili torti\ndefinition : Pili (from Latin pilus, hair) torti (from Latin tortus, twisted) refers to short and brittle hairs that appear flattened and twisted when viewed through a microscope.\nsynonyms :Flattened and twisted hair\n'}


{'id': 'HP_0003778', 'url': 'http://purl.obolibrary.org/obo/HP_0003778', 'lbl': 'Short mandibular rami', 'desc': 'label: Short mandibular rami\ndefinition : \nsynonyms :Decreased size of mandibular ramus; Short body and ramus of mandible; Short mandibular ramus; Underdeveloped mandibular rami; Decreased height of mandibular ramus\n'}


{'id': 'HP_0003779', 'url': 'http://purl.obolibrary.org/obo/HP_0003779', 'lbl': 'Antegonial notching of mandible', 'desc': 'label: Antegonial notching of mandible\ndefinition : \nsynonyms :Deep antegonial notch of mandible; Large antegonial notch of mandible\n'}


{'id': 'HP_0003781', 'url': 'http://purl.obolibrary.org/obo/HP_0003781', 'lbl': 'Excessive salivation', 'desc': 'label: Excessive salivation\ndefinition : Excessive production of saliva.\nsynonyms :Excessive production of saliva; Excessive salivation; Hypersalivation; Mouth watering; Oversalivation; Ptyalism; Watery mouth\n'}


{'id': 'HP_0003782', 'url': 'http://purl.obolibrary.org/obo/HP_0003782', 'lbl': 'Eunuchoid habitus', 'desc': 'label: Eunuchoid habitus\ndefinition : A body habitus that is tall, slim and underweight, with long legs and long arms (i.e., arm span exceeds height by 5 cm or more).\nsynonyms :\n'}


{'id': 'HP_0003783', 'url': 'http://purl.obolibrary.org/obo/HP_0003783', 'lbl': 'obsolete Externally rotated/abducted legs', 'desc': 'label: obsolete Externally rotated/abducted legs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003784', 'url': 'http://purl.obolibrary.org/obo/HP_0003784', 'lbl': 'Type 1 collagen overmodification', 'desc': 'label: Type 1 collagen overmodification\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003785', 'url': 'http://purl.obolibrary.org/obo/HP_0003785', 'lbl': 'Decreased CSF homovanillic acid concentration', 'desc': 'label: Decreased CSF homovanillic acid concentration\ndefinition : Decreased concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine.\nsynonyms :\n'}


{'id': 'HP_0003787', 'url': 'http://purl.obolibrary.org/obo/HP_0003787', 'lbl': 'Type 1 and type 2 muscle fiber minicore regions', 'desc': 'label: Type 1 and type 2 muscle fiber minicore regions\ndefinition : Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in type 1 and type 2 muscle fibers.\nsynonyms :Type 1 and type 2 muscle fibre minicore regions\n'}


{'id': 'HP_0003789', 'url': 'http://purl.obolibrary.org/obo/HP_0003789', 'lbl': 'Minicore myopathy', 'desc': 'label: Minicore myopathy\ndefinition : Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in muscle fibers.\nsynonyms :\n'}


{'id': 'HP_0003791', 'url': 'http://purl.obolibrary.org/obo/HP_0003791', 'lbl': 'Deposits immunoreactive to beta-amyloid protein', 'desc': 'label: Deposits immunoreactive to beta-amyloid protein\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003795', 'url': 'http://purl.obolibrary.org/obo/HP_0003795', 'lbl': 'Short middle phalanx of toe', 'desc': 'label: Short middle phalanx of toe\ndefinition : Developmental hypoplasia (shortening) of middle phalanx of toe.\nsynonyms :Short middle bones (feet); Short middle phalanges of toes\n'}


{'id': 'HP_0003796', 'url': 'http://purl.obolibrary.org/obo/HP_0003796', 'lbl': 'Irregular iliac crest', 'desc': 'label: Irregular iliac crest\ndefinition : Irregularity of the iliac crest, which is the superior border of the wing of the ilium.\nsynonyms :\n'}


{'id': 'HP_0003797', 'url': 'http://purl.obolibrary.org/obo/HP_0003797', 'lbl': 'Limb-girdle muscle atrophy', 'desc': 'label: Limb-girdle muscle atrophy\ndefinition : Muscular atrophy affecting the muscles of the limb girdle.\nsynonyms :Limb-girdle myopathy; Wasting of limb-girdle muscle\n'}


{'id': 'HP_0003798', 'url': 'http://purl.obolibrary.org/obo/HP_0003798', 'lbl': 'Nemaline bodies', 'desc': 'label: Nemaline bodies\ndefinition : Nemaline rods are abnormal bodies that can occur in skeletal muscle fibers. The rods can be observed on histological analysis of muscle biopsy tissue or upon electron microscopy, where they appear either as extensions of sarcomeric Z-lines, in random array without obvious attachment to Z-lines (often in areas devoid of sarcomeres) or in large clusters localized at the sarcolemma or intermyofibrillar spaces.\nsynonyms :Nemaline rods\n'}


{'id': 'HP_0003799', 'url': 'http://purl.obolibrary.org/obo/HP_0003799', 'lbl': 'Marked delay in bone age', 'desc': 'label: Marked delay in bone age\ndefinition : \nsynonyms :Marked delay in bone age; Marked retardation in skeletal maturation; Markedly retarded bone age\n'}


{'id': 'HP_0003800', 'url': 'http://purl.obolibrary.org/obo/HP_0003800', 'lbl': 'Muscle abnormality related to mitochondrial dysfunction', 'desc': 'label: Muscle abnormality related to mitochondrial dysfunction\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003803', 'url': 'http://purl.obolibrary.org/obo/HP_0003803', 'lbl': 'Type 1 muscle fiber predominance', 'desc': 'label: Type 1 muscle fiber predominance\ndefinition : An abnormal predominance of type I muscle fibers (in general, this feature can only be observed on muscle biopsy).\nsynonyms :Type 1 muscle fibre predominance; Type I muscle fiber predominance; Type I muscle fibre predominance\n'}


{'id': 'HP_0003805', 'url': 'http://purl.obolibrary.org/obo/HP_0003805', 'lbl': 'Rimmed vacuoles', 'desc': 'label: Rimmed vacuoles\ndefinition : Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, rimmed vacuoles are popcorn-like clear vacuoles with a densely blue rim. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions.\nsynonyms :Rimmed vacuoles on biopsy\n'}


{'id': 'HP_0003808', 'url': 'http://purl.obolibrary.org/obo/HP_0003808', 'lbl': 'Abnormal muscle tone', 'desc': 'label: Abnormal muscle tone\ndefinition : \nsynonyms :Abnormal muscle tone\n'}


{'id': 'HP_0003809', 'url': 'http://purl.obolibrary.org/obo/HP_0003809', 'lbl': 'Reduced intrathoracic adipose tissue', 'desc': 'label: Reduced intrathoracic adipose tissue\ndefinition : An abnormally reduced amount of adipose tissue in the thoracic cavity.\nsynonyms :\n'}


{'id': 'HP_0003810', 'url': 'http://purl.obolibrary.org/obo/HP_0003810', 'lbl': 'Late-onset distal muscle weakness', 'desc': 'label: Late-onset distal muscle weakness\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003811', 'url': 'http://purl.obolibrary.org/obo/HP_0003811', 'lbl': 'Neonatal death', 'desc': 'label: Neonatal death\ndefinition : Death within the first 28 days of life.\nsynonyms :Neonatal lethal\n'}


{'id': 'HP_0003812', 'url': 'http://purl.obolibrary.org/obo/HP_0003812', 'lbl': 'Phenotypic variability', 'desc': 'label: Phenotypic variability\ndefinition : A variability of phenotypic features.\nsynonyms :Clinical heterogeneity; Highly variable clinical phenotype; Highly variable phenotype; Highly variable phenotype and severity; Highly variable phenotype, even within families; Variable phenotype; Variable phenotypic severity\n'}


{'id': 'HP_0003819', 'url': 'http://purl.obolibrary.org/obo/HP_0003819', 'lbl': 'Death in childhood', 'desc': 'label: Death in childhood\ndefinition : Death in during childhood, defined here as between the ages of 2 and 10 years.\nsynonyms :Death in childhood\n'}


{'id': 'HP_0003826', 'url': 'http://purl.obolibrary.org/obo/HP_0003826', 'lbl': 'Stillbirth', 'desc': 'label: Stillbirth\ndefinition : Death of the fetus in utero after at least 22 weeks of gestation.\nsynonyms :Late fetal death; Stillbirth; Stillborn; Fetal death; Fetal demise; Foetal death\n'}


{'id': 'HP_0003828', 'url': 'http://purl.obolibrary.org/obo/HP_0003828', 'lbl': 'Variable expressivity', 'desc': 'label: Variable expressivity\ndefinition : A variable severity of phenotypic features.\nsynonyms :Variable severity; Highly variable severity\n'}


{'id': 'HP_0003829', 'url': 'http://purl.obolibrary.org/obo/HP_0003829', 'lbl': 'Typified by incomplete penetrance', 'desc': 'label: Typified by incomplete penetrance\ndefinition : Description of conditions in which not all individuals with a given genotype exhibit the disease. Penetrance is the proportion that develop disease given a lifespan of 80 years.\nsynonyms :Incomplete penetrance; Reduced penetrance\n'}


{'id': 'HP_0003831', 'url': 'http://purl.obolibrary.org/obo/HP_0003831', 'lbl': 'Typified by age-related disease onset', 'desc': 'label: Typified by age-related disease onset\ndefinition : Description of conditions in which age of onset is typically later in life and in which penetrance is dependent on the age of the subject.\nsynonyms :Age dependent penetrance; Age-dependent penetrance; Typified by age-related penetrance\n'}


{'id': 'HP_0003832', 'url': 'http://purl.obolibrary.org/obo/HP_0003832', 'lbl': 'Abnormality of the tibial plateaux', 'desc': 'label: Abnormality of the tibial plateaux\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003833', 'url': 'http://purl.obolibrary.org/obo/HP_0003833', 'lbl': 'Laterally deficient tibial plateaux', 'desc': 'label: Laterally deficient tibial plateaux\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003834', 'url': 'http://purl.obolibrary.org/obo/HP_0003834', 'lbl': 'Shoulder dislocation', 'desc': 'label: Shoulder dislocation\ndefinition : A displacement or misalignment of the humerus with respect to the other bones of the should joint. Note that a subluxation is a partial dislocation.\nsynonyms :Shoulder dislocation\n'}


{'id': 'HP_0003835', 'url': 'http://purl.obolibrary.org/obo/HP_0003835', 'lbl': 'Shoulder subluxation', 'desc': 'label: Shoulder subluxation\ndefinition : A partial dislocation of the shoulder joint.\nsynonyms :Partial shoulder dislocation\n'}


{'id': 'HP_0003836', 'url': 'http://purl.obolibrary.org/obo/HP_0003836', 'lbl': 'Stippled calcification of the shoulder', 'desc': 'label: Stippled calcification of the shoulder\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003837', 'url': 'http://purl.obolibrary.org/obo/HP_0003837', 'lbl': 'Soft-tissue ossification around the shoulders', 'desc': 'label: Soft-tissue ossification around the shoulders\ndefinition : Formation of calcified tissue in the soft tissues surrounding the shoulder.\nsynonyms :Calcification of the soft-tissue around the shoulders\n'}


{'id': 'HP_0003839', 'url': 'http://purl.obolibrary.org/obo/HP_0003839', 'lbl': 'Abnormality of upper limb epiphysis morphology', 'desc': 'label: Abnormality of upper limb epiphysis morphology\ndefinition : \nsynonyms :Abnormal shape of end part of upper limb long bones; Abnormality involving the epiphyses of the upper limbs; Epihyseal plate abnormality of the upper limbs\n'}


{'id': 'HP_0003840', 'url': 'http://purl.obolibrary.org/obo/HP_0003840', 'lbl': 'Delayed upper limb epiphyseal ossification', 'desc': 'label: Delayed upper limb epiphyseal ossification\ndefinition : A delay in the process of formation and maturation of the epiphysis of one or more long bones of the upper limbs.\nsynonyms :Delayed maturation fo the end part of the upper limb bone\n'}


{'id': 'HP_0003841', 'url': 'http://purl.obolibrary.org/obo/HP_0003841', 'lbl': 'Fragmented epiphyses of the upper limbs', 'desc': 'label: Fragmented epiphyses of the upper limbs\ndefinition : \nsynonyms :Fragmented end part of upper limb bones\n'}


{'id': 'HP_0003842', 'url': 'http://purl.obolibrary.org/obo/HP_0003842', 'lbl': 'Irregular epiphyses of the upper limbs', 'desc': 'label: Irregular epiphyses of the upper limbs\ndefinition : \nsynonyms :Irregular end part of upper limb bones\n'}


{'id': 'HP_0003843', 'url': 'http://purl.obolibrary.org/obo/HP_0003843', 'lbl': 'Round epiphyses of the upper limbs', 'desc': 'label: Round epiphyses of the upper limbs\ndefinition : \nsynonyms :Round end part of upper limb bones\n'}


{'id': 'HP_0003844', 'url': 'http://purl.obolibrary.org/obo/HP_0003844', 'lbl': 'Small epiphyses of the upper limbs', 'desc': 'label: Small epiphyses of the upper limbs\ndefinition : \nsynonyms :Small end part of upper limb bones\n'}


{'id': 'HP_0003846', 'url': 'http://purl.obolibrary.org/obo/HP_0003846', 'lbl': 'Wide epiphyseal plates of the upper limbs', 'desc': 'label: Wide epiphyseal plates of the upper limbs\ndefinition : \nsynonyms :Broad epiphyseal plates of the upper limbs; Broad growth plates of upper limbs\n'}


{'id': 'HP_0003848', 'url': 'http://purl.obolibrary.org/obo/HP_0003848', 'lbl': 'Cupped metaphyses of the upper limbs', 'desc': 'label: Cupped metaphyses of the upper limbs\ndefinition : \nsynonyms :Cupped wide portion of the upper limb bone\n'}


{'id': 'HP_0003849', 'url': 'http://purl.obolibrary.org/obo/HP_0003849', 'lbl': 'Flared upper limb metaphysis', 'desc': 'label: Flared upper limb metaphysis\ndefinition : The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the arm.\nsynonyms :Flared metaphyses of the upper limbs; Flared wide portion of the upper limb bone\n'}


{'id': 'HP_0003850', 'url': 'http://purl.obolibrary.org/obo/HP_0003850', 'lbl': 'Upper-limb metaphyseal irregularity', 'desc': 'label: Upper-limb metaphyseal irregularity\ndefinition : \nsynonyms :Irregular metaphyses of the upper limbs; Irregular wide portion of upper limb bones\n'}


{'id': 'HP_0003851', 'url': 'http://purl.obolibrary.org/obo/HP_0003851', 'lbl': 'Lytic defects in metaphyses of the upper limbs', 'desc': 'label: Lytic defects in metaphyses of the upper limbs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003852', 'url': 'http://purl.obolibrary.org/obo/HP_0003852', 'lbl': 'Normal density transverse bands in metaphyses of the upper limbs', 'desc': 'label: Normal density transverse bands in metaphyses of the upper limbs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003853', 'url': 'http://purl.obolibrary.org/obo/HP_0003853', 'lbl': 'Sclerosis with transverse striations in metaphyses of the upper limbs', 'desc': 'label: Sclerosis with transverse striations in metaphyses of the upper limbs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003854', 'url': 'http://purl.obolibrary.org/obo/HP_0003854', 'lbl': 'Sclerosis of metaphyses of the upper limbs', 'desc': 'label: Sclerosis of metaphyses of the upper limbs\ndefinition : \nsynonyms :Increased bone density in wide portion of the upper limb bones\n'}


{'id': 'HP_0003855', 'url': 'http://purl.obolibrary.org/obo/HP_0003855', 'lbl': 'Spurred metaphyses of the upper limbs', 'desc': 'label: Spurred metaphyses of the upper limbs\ndefinition : \nsynonyms :Spurred wide portion of upper limb bone\n'}


{'id': 'HP_0003856', 'url': 'http://purl.obolibrary.org/obo/HP_0003856', 'lbl': 'Upper limb metaphyseal widening', 'desc': 'label: Upper limb metaphyseal widening\ndefinition : Increased width (breadth) of metaphyses of the arms.\nsynonyms :Broad wide portion of upper limb bone; Wide/broad metaphyses of the upper limbs\n'}


{'id': 'HP_0003858', 'url': 'http://purl.obolibrary.org/obo/HP_0003858', 'lbl': 'Cortical diaphyseal irregularity of the upper limbs', 'desc': 'label: Cortical diaphyseal irregularity of the upper limbs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003859', 'url': 'http://purl.obolibrary.org/obo/HP_0003859', 'lbl': 'Cortical diaphyseal thickening of the upper limbs', 'desc': 'label: Cortical diaphyseal thickening of the upper limbs\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003860', 'url': 'http://purl.obolibrary.org/obo/HP_0003860', 'lbl': 'Diaphyseal sclerosis of the upper limbs', 'desc': 'label: Diaphyseal sclerosis of the upper limbs\ndefinition : An elevation in bone density in one or more diaphyses of the arms. Sclerosis is normally detected on a radiograph as an area of increased opacity.\nsynonyms :Increased bone density in central part of long bone of upper limbs\n'}


{'id': 'HP_0003861', 'url': 'http://purl.obolibrary.org/obo/HP_0003861', 'lbl': 'Broad diaphyses of the upper limbs', 'desc': 'label: Broad diaphyses of the upper limbs\ndefinition : \nsynonyms :Broad shaft of long bone of the upper limbs; Wide diaphyses of the upper limbs; Wide shaft of long bone of the upper limbs\n'}


{'id': 'HP_0003862', 'url': 'http://purl.obolibrary.org/obo/HP_0003862', 'lbl': 'Absent humerus', 'desc': 'label: Absent humerus\ndefinition : Missing humerus bone associated with congenital failure of development.\nsynonyms :Absent long bone in upper arm; Aplasia of the humerus; Aplastic humerus\n'}


{'id': 'HP_0003863', 'url': 'http://purl.obolibrary.org/obo/HP_0003863', 'lbl': 'Angulated humerus', 'desc': 'label: Angulated humerus\ndefinition : \nsynonyms :Angulated long bone in upper arm\n'}


{'id': 'HP_0003864', 'url': 'http://purl.obolibrary.org/obo/HP_0003864', 'lbl': 'Bifid humerus', 'desc': 'label: Bifid humerus\ndefinition : Clefting affecting the humerus.\nsynonyms :Notched long bone in upper arm\n'}


{'id': 'HP_0003865', 'url': 'http://purl.obolibrary.org/obo/HP_0003865', 'lbl': 'Bowed humerus', 'desc': 'label: Bowed humerus\ndefinition : A bending or abnormal curvature of the humerus.\nsynonyms :Bowed long bone in upper arm; Bowing of the humerus; Humeral bowing\n'}


{'id': 'HP_0003866', 'url': 'http://purl.obolibrary.org/obo/HP_0003866', 'lbl': 'Coarse humeral trabeculae', 'desc': 'label: Coarse humeral trabeculae\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003867', 'url': 'http://purl.obolibrary.org/obo/HP_0003867', 'lbl': 'Humeral cortical irregularity', 'desc': 'label: Humeral cortical irregularity\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003868', 'url': 'http://purl.obolibrary.org/obo/HP_0003868', 'lbl': 'Humeral cortical thickening', 'desc': 'label: Humeral cortical thickening\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003869', 'url': 'http://purl.obolibrary.org/obo/HP_0003869', 'lbl': 'Humeral cortical thinning', 'desc': 'label: Humeral cortical thinning\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003870', 'url': 'http://purl.obolibrary.org/obo/HP_0003870', 'lbl': 'Crumpled humerus', 'desc': 'label: Crumpled humerus\ndefinition : \nsynonyms :Crumpled long bone in upper arm\n'}


{'id': 'HP_0003871', 'url': 'http://purl.obolibrary.org/obo/HP_0003871', 'lbl': 'Deformed humerus', 'desc': 'label: Deformed humerus\ndefinition : \nsynonyms :Deformed long bone in upper arm\n'}


{'id': 'HP_0003872', 'url': 'http://purl.obolibrary.org/obo/HP_0003872', 'lbl': 'Humeral exostoses', 'desc': 'label: Humeral exostoses\ndefinition : Presence of more than one exostosis originating in one or noth humerus bones. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage.\nsynonyms :\n'}


{'id': 'HP_0003874', 'url': 'http://purl.obolibrary.org/obo/HP_0003874', 'lbl': 'Humerus varus', 'desc': 'label: Humerus varus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003875', 'url': 'http://purl.obolibrary.org/obo/HP_0003875', 'lbl': 'Humeral lytic defects', 'desc': 'label: Humeral lytic defects\ndefinition : Destruction of an area of humerus bone due to a disease process, such as cancer.\nsynonyms :Lytic defects of the humerus\n'}


{'id': 'HP_0003876', 'url': 'http://purl.obolibrary.org/obo/HP_0003876', 'lbl': 'Osteoporotic humerus', 'desc': 'label: Osteoporotic humerus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003877', 'url': 'http://purl.obolibrary.org/obo/HP_0003877', 'lbl': 'Oval transradiancy of humerus', 'desc': 'label: Oval transradiancy of humerus\ndefinition : \nsynonyms :Humeral oval transradiancy\n'}


{'id': 'HP_0003878', 'url': 'http://purl.obolibrary.org/obo/HP_0003878', 'lbl': 'Periosteal new bone of humerus', 'desc': 'label: Periosteal new bone of humerus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003879', 'url': 'http://purl.obolibrary.org/obo/HP_0003879', 'lbl': 'Humeral pseudarthrosis', 'desc': 'label: Humeral pseudarthrosis\ndefinition : \nsynonyms :False joint (long bone in upper arm)\n'}


{'id': 'HP_0003880', 'url': 'http://purl.obolibrary.org/obo/HP_0003880', 'lbl': 'Sclerotic foci of the humerus', 'desc': 'label: Sclerotic foci of the humerus\ndefinition : \nsynonyms :Humeral sclerotic foci\n'}


{'id': 'HP_0003881', 'url': 'http://purl.obolibrary.org/obo/HP_0003881', 'lbl': 'Humeral sclerosis', 'desc': 'label: Humeral sclerosis\ndefinition : \nsynonyms :Increased bone density in long bone of upper arm; Sclerosis of humerus\n'}


{'id': 'HP_0003882', 'url': 'http://purl.obolibrary.org/obo/HP_0003882', 'lbl': 'Slender humerus', 'desc': 'label: Slender humerus\ndefinition : Reduction in diameter of the humerus.\nsynonyms :Slender long bone of upper arm\n'}


{'id': 'HP_0003883', 'url': 'http://purl.obolibrary.org/obo/HP_0003883', 'lbl': 'Tapered humerus', 'desc': 'label: Tapered humerus\ndefinition : \nsynonyms :Tapered long bone of upper arm\n'}


{'id': 'HP_0003884', 'url': 'http://purl.obolibrary.org/obo/HP_0003884', 'lbl': 'Triangular humerus', 'desc': 'label: Triangular humerus\ndefinition : \nsynonyms :Triangular long bone of upper arm\n'}


{'id': 'HP_0003885', 'url': 'http://purl.obolibrary.org/obo/HP_0003885', 'lbl': 'Undermodeled humerus', 'desc': 'label: Undermodeled humerus\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003886', 'url': 'http://purl.obolibrary.org/obo/HP_0003886', 'lbl': 'Wide humerus', 'desc': 'label: Wide humerus\ndefinition : \nsynonyms :Broad humerus; Wide long bone of upper arm\n'}


{'id': 'HP_0003887', 'url': 'http://purl.obolibrary.org/obo/HP_0003887', 'lbl': 'Abnormal humeral head morphology', 'desc': 'label: Abnormal humeral head morphology\ndefinition : \nsynonyms :Abnormal head of long bone in upper arm; Abnormality of the humeral heads\n'}


{'id': 'HP_0003888', 'url': 'http://purl.obolibrary.org/obo/HP_0003888', 'lbl': 'Flattened humeral heads', 'desc': 'label: Flattened humeral heads\ndefinition : \nsynonyms :Flattended head of long bone in upper arm\n'}


{'id': 'HP_0003889', 'url': 'http://purl.obolibrary.org/obo/HP_0003889', 'lbl': 'Abnormal deltoid tuberosity morphology', 'desc': 'label: Abnormal deltoid tuberosity morphology\ndefinition : \nsynonyms :Abnormality of the deltoid tuberosities\n'}


{'id': 'HP_0003890', 'url': 'http://purl.obolibrary.org/obo/HP_0003890', 'lbl': 'Prominent deltoid tuberosities', 'desc': 'label: Prominent deltoid tuberosities\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003891', 'url': 'http://purl.obolibrary.org/obo/HP_0003891', 'lbl': 'Abnormality of the humeral epiphysis', 'desc': 'label: Abnormality of the humeral epiphysis\ndefinition : An anomaly of the humeral epiphysis.\nsynonyms :Abnormality of end part of the long bone of the upper arm; Abnormality of the humeral epiphyses\n'}


{'id': 'HP_0003892', 'url': 'http://purl.obolibrary.org/obo/HP_0003892', 'lbl': 'Absent humeral epiphyseal ossification', 'desc': 'label: Absent humeral epiphyseal ossification\ndefinition : Lack of formation of bone in the epiphysis of the humerus.\nsynonyms :Absent maturation of end part of long bone in upper arm; Absent ossification of the humeral epiphyses\n'}


{'id': 'HP_0003893', 'url': 'http://purl.obolibrary.org/obo/HP_0003893', 'lbl': 'Advanced ossification of the humeral epiphysis', 'desc': 'label: Advanced ossification of the humeral epiphysis\ndefinition : Ossification of the humeral epiphysis at an earlier age than normal.\nsynonyms :Accelerated maturation of end part of long bone in upper arm; Advanced maturation of the humeral epiphyses\n'}


{'id': 'HP_0003894', 'url': 'http://purl.obolibrary.org/obo/HP_0003894', 'lbl': 'Delayed humeral epiphyseal ossification', 'desc': 'label: Delayed humeral epiphyseal ossification\ndefinition : A delay in the process of formation and maturation of the humeral epiphysis.\nsynonyms :Delayed maturation/delayed ossification of the humeral epiphyses; Delayed maturation of the end part of the long bone in upper arm\n'}


{'id': 'HP_0003895', 'url': 'http://purl.obolibrary.org/obo/HP_0003895', 'lbl': 'Flattened humeral epiphyses', 'desc': 'label: Flattened humeral epiphyses\ndefinition : \nsynonyms :Flattened end part of long bone in upper arm\n'}


{'id': 'HP_0003896', 'url': 'http://purl.obolibrary.org/obo/HP_0003896', 'lbl': 'Irregular humeral epiphyses', 'desc': 'label: Irregular humeral epiphyses\ndefinition : \nsynonyms :Irregular end part of long bone in upper arm\n'}


{'id': 'HP_0003897', 'url': 'http://purl.obolibrary.org/obo/HP_0003897', 'lbl': 'Irregular ossification of the humeral epiphyses', 'desc': 'label: Irregular ossification of the humeral epiphyses\ndefinition : \nsynonyms :Irregular maturation of the end part of the long bone in upper arm\n'}


{'id': 'HP_0003898', 'url': 'http://purl.obolibrary.org/obo/HP_0003898', 'lbl': 'Large humeral epiphyses', 'desc': 'label: Large humeral epiphyses\ndefinition : \nsynonyms :Large end part of long bone in upper arm\n'}


{'id': 'HP_0003899', 'url': 'http://purl.obolibrary.org/obo/HP_0003899', 'lbl': 'Round humeral epiphyses', 'desc': 'label: Round humeral epiphyses\ndefinition : \nsynonyms :Round end part of long bone in upper arm\n'}


{'id': 'HP_0003900', 'url': 'http://purl.obolibrary.org/obo/HP_0003900', 'lbl': 'Small humeral epiphyses', 'desc': 'label: Small humeral epiphyses\ndefinition : \nsynonyms :Small end part of long bone in upper arm\n'}


{'id': 'HP_0003901', 'url': 'http://purl.obolibrary.org/obo/HP_0003901', 'lbl': 'Stippled calcification of the humeral epiphyses', 'desc': 'label: Stippled calcification of the humeral epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003902', 'url': 'http://purl.obolibrary.org/obo/HP_0003902', 'lbl': 'Epiphyseal stippling of the humerus', 'desc': 'label: Epiphyseal stippling of the humerus\ndefinition : The presence of abnormal punctate (speckled, dot-like) calcifications in the humeral epiphysis.\nsynonyms :Stippled ossification of the humeral epiphyses\n'}


{'id': 'HP_0003903', 'url': 'http://purl.obolibrary.org/obo/HP_0003903', 'lbl': 'Broad humeral epiphyses', 'desc': 'label: Broad humeral epiphyses\ndefinition : Increased width of the humeral epiphysis.\nsynonyms :Wide end part of long bone in upper arm; Wide humeral epiphyses\n'}


{'id': 'HP_0003904', 'url': 'http://purl.obolibrary.org/obo/HP_0003904', 'lbl': 'Wide epiphyses of the upper limbs', 'desc': 'label: Wide epiphyses of the upper limbs\ndefinition : \nsynonyms :Broad epiphyses of the upper limbs; Wide end part of upper limb bones\n'}


{'id': 'HP_0003905', 'url': 'http://purl.obolibrary.org/obo/HP_0003905', 'lbl': 'Abnormality of the humeral epiphyseal plate', 'desc': 'label: Abnormality of the humeral epiphyseal plate\ndefinition : \nsynonyms :Abnormality of arm long bone growth plate\n'}


{'id': 'HP_0003906', 'url': 'http://purl.obolibrary.org/obo/HP_0003906', 'lbl': 'Broad humeral epiphyseal plate', 'desc': 'label: Broad humeral epiphyseal plate\ndefinition : Increased width of the humeral epiphyseal growth plate.\nsynonyms :Wide long bone of arm growth plate; Wide humeral epiphyseal plate\n'}


{'id': 'HP_0003907', 'url': 'http://purl.obolibrary.org/obo/HP_0003907', 'lbl': 'Abnormal humeral metaphysis morphology', 'desc': 'label: Abnormal humeral metaphysis morphology\ndefinition : \nsynonyms :Abnormality of the humeral metaphyses; Abnormality of the wide portion of the long bone in upper arm\n'}


{'id': 'HP_0003908', 'url': 'http://purl.obolibrary.org/obo/HP_0003908', 'lbl': 'Corner fracture of metaphysis', 'desc': 'label: Corner fracture of metaphysis\ndefinition : Fracture or fragmentation at the lateral portion of the metaphysis of a long bone. The radiographic appearance is that of a small corner of metaphysis separated from the metaphyseal edge by thin linear radiolucency. This feature can be observed in child abuse but fragmented appearance of the metaphysis or facture-like lesions can also be detected in the setting of certain skeletal dysplasias.\nsynonyms :Bucket handle fracture; Metaphyseal corner fracture\n'}


{'id': 'HP_0003909', 'url': 'http://purl.obolibrary.org/obo/HP_0003909', 'lbl': 'Cortical subperiosteal resorption of humeral metaphyses', 'desc': 'label: Cortical subperiosteal resorption of humeral metaphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003910', 'url': 'http://purl.obolibrary.org/obo/HP_0003910', 'lbl': 'Enlarged humeral metaphyses', 'desc': 'label: Enlarged humeral metaphyses\ndefinition : \nsynonyms :Enlarged wide portion of long bone of upper arm; Expanded humeral metaphyses\n'}


{'id': 'HP_0003911', 'url': 'http://purl.obolibrary.org/obo/HP_0003911', 'lbl': 'Flared humeral metaphysis', 'desc': 'label: Flared humeral metaphysis\ndefinition : Flaring (increase of width with a splayed appearance) of the humeral metaphysis.\nsynonyms :Flared wide portion of long bone of upper arm; Wide/broad humeral metaphysis; Flared humerus\n'}


{'id': 'HP_0003912', 'url': 'http://purl.obolibrary.org/obo/HP_0003912', 'lbl': 'Frayed humeral metaphyses', 'desc': 'label: Frayed humeral metaphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003913', 'url': 'http://purl.obolibrary.org/obo/HP_0003913', 'lbl': 'Humeral metaphyseal irregularity', 'desc': 'label: Humeral metaphyseal irregularity\ndefinition : \nsynonyms :Irregular humeral metaphyses; Irregular wide portion of long bone in upper arm\n'}


{'id': 'HP_0003914', 'url': 'http://purl.obolibrary.org/obo/HP_0003914', 'lbl': 'Irregular ossification of humeral metaphyses', 'desc': 'label: Irregular ossification of humeral metaphyses\ndefinition : \nsynonyms :Irregular bone maturation of the wide portion of the long bone in upper arm\n'}


{'id': 'HP_0003915', 'url': 'http://purl.obolibrary.org/obo/HP_0003915', 'lbl': 'Lytic defects of the humeral metaphysis', 'desc': 'label: Lytic defects of the humeral metaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003916', 'url': 'http://purl.obolibrary.org/obo/HP_0003916', 'lbl': 'Normal-density transverse humeral bands', 'desc': 'label: Normal-density transverse humeral bands\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003917', 'url': 'http://purl.obolibrary.org/obo/HP_0003917', 'lbl': 'Pointed humeral metaphysis', 'desc': 'label: Pointed humeral metaphysis\ndefinition : \nsynonyms :Pointed wide portion of long bone of upper arm\n'}


{'id': 'HP_0003918', 'url': 'http://purl.obolibrary.org/obo/HP_0003918', 'lbl': 'Sclerotic humeral metaphysis', 'desc': 'label: Sclerotic humeral metaphysis\ndefinition : \nsynonyms :Hardening of wide portion of long bone of upper arm; Stiffening of wide portion of long bone of upper arm\n'}


{'id': 'HP_0003919', 'url': 'http://purl.obolibrary.org/obo/HP_0003919', 'lbl': 'Sclerotic humeral metaphysis with longitudinal striations', 'desc': 'label: Sclerotic humeral metaphysis with longitudinal striations\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003920', 'url': 'http://purl.obolibrary.org/obo/HP_0003920', 'lbl': 'Sloping humeral metaphysis', 'desc': 'label: Sloping humeral metaphysis\ndefinition : \nsynonyms :Sloping metaphysis of long bone of upper arm\n'}


{'id': 'HP_0003921', 'url': 'http://purl.obolibrary.org/obo/HP_0003921', 'lbl': 'Laterally sloping humeral metaphysis', 'desc': 'label: Laterally sloping humeral metaphysis\ndefinition : \nsynonyms :Laterally sloping metaphysis of long bone of upper arm\n'}


{'id': 'HP_0003922', 'url': 'http://purl.obolibrary.org/obo/HP_0003922', 'lbl': 'Spurred humeral metaphysis', 'desc': 'label: Spurred humeral metaphysis\ndefinition : \nsynonyms :Spurred metaphysis of long bone of upper arm\n'}


{'id': 'HP_0003923', 'url': 'http://purl.obolibrary.org/obo/HP_0003923', 'lbl': 'Square humeral metaphysis', 'desc': 'label: Square humeral metaphysis\ndefinition : \nsynonyms :Square metaphysis of long bone of upper arm\n'}


{'id': 'HP_0003924', 'url': 'http://purl.obolibrary.org/obo/HP_0003924', 'lbl': 'Stippled calcification of humeral metaphysis', 'desc': 'label: Stippled calcification of humeral metaphysis\ndefinition : \nsynonyms :Speckled calcification in metaphysis of long bone of upper arm\n'}


{'id': 'HP_0003926', 'url': 'http://purl.obolibrary.org/obo/HP_0003926', 'lbl': 'Abnormal humeral diaphysis morphology', 'desc': 'label: Abnormal humeral diaphysis morphology\ndefinition : An anomaly of the humeral diaphysis.\nsynonyms :Abnormality of shaft of long bone in upper arm; Abnormality of the humeral diaphysis\n'}


{'id': 'HP_0003927', 'url': 'http://purl.obolibrary.org/obo/HP_0003927', 'lbl': 'Cortical irregularity of humeral diaphysis', 'desc': 'label: Cortical irregularity of humeral diaphysis\ndefinition : An abnormal irregularity of the cortical surface of the diaphysis (shaft) of the humerus.\nsynonyms :\n'}


{'id': 'HP_0003928', 'url': 'http://purl.obolibrary.org/obo/HP_0003928', 'lbl': 'Cortical thickening of humeral diaphysis', 'desc': 'label: Cortical thickening of humeral diaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003929', 'url': 'http://purl.obolibrary.org/obo/HP_0003929', 'lbl': 'Ground glass opacity of humeral diaphysis', 'desc': 'label: Ground glass opacity of humeral diaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003930', 'url': 'http://purl.obolibrary.org/obo/HP_0003930', 'lbl': 'Lytic defects of humeral diaphysis', 'desc': 'label: Lytic defects of humeral diaphysis\ndefinition : \nsynonyms :Humeral diaphyseal lysis\n'}


{'id': 'HP_0003931', 'url': 'http://purl.obolibrary.org/obo/HP_0003931', 'lbl': 'Periosteal new bone of humeral diaphysis', 'desc': 'label: Periosteal new bone of humeral diaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003932', 'url': 'http://purl.obolibrary.org/obo/HP_0003932', 'lbl': 'Sclerotic foci of humeral diaphysis', 'desc': 'label: Sclerotic foci of humeral diaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003933', 'url': 'http://purl.obolibrary.org/obo/HP_0003933', 'lbl': 'Sclerosis of humeral diaphysis', 'desc': 'label: Sclerosis of humeral diaphysis\ndefinition : \nsynonyms :Increased bone density in shaft of long bone in upper arm\n'}


{'id': 'HP_0003934', 'url': 'http://purl.obolibrary.org/obo/HP_0003934', 'lbl': 'Slender humeral diaphysis', 'desc': 'label: Slender humeral diaphysis\ndefinition : \nsynonyms :Slender shaft of long bone in upper arm\n'}


{'id': 'HP_0003935', 'url': 'http://purl.obolibrary.org/obo/HP_0003935', 'lbl': 'Wide humeral diaphysis', 'desc': 'label: Wide humeral diaphysis\ndefinition : Increased width of the humeral diaphysis.\nsynonyms :Broad humeral diaphysis; Broad shaft of long bone in upper arm; Wide shaft of long bone in upper arm\n'}


{'id': 'HP_0003938', 'url': 'http://purl.obolibrary.org/obo/HP_0003938', 'lbl': 'Synostosis involving the elbow', 'desc': 'label: Synostosis involving the elbow\ndefinition : \nsynonyms :Bone fusion involving the elbow\n'}


{'id': 'HP_0003939', 'url': 'http://purl.obolibrary.org/obo/HP_0003939', 'lbl': 'Humeroulnar synostosis', 'desc': 'label: Humeroulnar synostosis\ndefinition : An abnormal osseous union (fusion) between the ulna and the humerus.\nsynonyms :Humeral ulnar synostosis\n'}


{'id': 'HP_0003940', 'url': 'http://purl.obolibrary.org/obo/HP_0003940', 'lbl': 'Osteoarthritis of the elbow', 'desc': 'label: Osteoarthritis of the elbow\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003941', 'url': 'http://purl.obolibrary.org/obo/HP_0003941', 'lbl': 'Stippled calcification of the elbow', 'desc': 'label: Stippled calcification of the elbow\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003942', 'url': 'http://purl.obolibrary.org/obo/HP_0003942', 'lbl': 'Synovial chondromatosis of the elbow', 'desc': 'label: Synovial chondromatosis of the elbow\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003943', 'url': 'http://purl.obolibrary.org/obo/HP_0003943', 'lbl': 'Abnormality of the joint spaces of the elbow', 'desc': 'label: Abnormality of the joint spaces of the elbow\ndefinition : \nsynonyms :Abnormality of the joint spaces of the elbow\n'}


{'id': 'HP_0003944', 'url': 'http://purl.obolibrary.org/obo/HP_0003944', 'lbl': 'Narrow joint spaces of the elbow', 'desc': 'label: Narrow joint spaces of the elbow\ndefinition : \nsynonyms :Narrow joint spaces of the elbow\n'}


{'id': 'HP_0003945', 'url': 'http://purl.obolibrary.org/obo/HP_0003945', 'lbl': 'Irregular articular surfaces of the elbow joints', 'desc': 'label: Irregular articular surfaces of the elbow joints\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003946', 'url': 'http://purl.obolibrary.org/obo/HP_0003946', 'lbl': 'Abnormality of the epiphyses of the elbow', 'desc': 'label: Abnormality of the epiphyses of the elbow\ndefinition : \nsynonyms :Abnormality of end part of the elbow bone\n'}


{'id': 'HP_0003947', 'url': 'http://purl.obolibrary.org/obo/HP_0003947', 'lbl': 'Delayed elbow epiphyseal ossification', 'desc': 'label: Delayed elbow epiphyseal ossification\ndefinition : A delay in the process of formation and maturation of the epiphysis of one or more long bones that are part of the elbow.\nsynonyms :Delayed maturation of the end part of the elbow bone\n'}


{'id': 'HP_0003948', 'url': 'http://purl.obolibrary.org/obo/HP_0003948', 'lbl': 'Irregular epiphyses of the elbow', 'desc': 'label: Irregular epiphyses of the elbow\ndefinition : \nsynonyms :Irregular end part of the elbow bone\n'}


{'id': 'HP_0003949', 'url': 'http://purl.obolibrary.org/obo/HP_0003949', 'lbl': 'Abnormal elbow metaphysis morphology', 'desc': 'label: Abnormal elbow metaphysis morphology\ndefinition : \nsynonyms :Abnormal wide portion of elbow bone\n'}


{'id': 'HP_0003950', 'url': 'http://purl.obolibrary.org/obo/HP_0003950', 'lbl': 'Flared elbow metaphyses', 'desc': 'label: Flared elbow metaphyses\ndefinition : \nsynonyms :Flared wide portion of elbow bone\n'}


{'id': 'HP_0003951', 'url': 'http://purl.obolibrary.org/obo/HP_0003951', 'lbl': 'Distal humeral metaphyseal irregularity', 'desc': 'label: Distal humeral metaphyseal irregularity\ndefinition : Irregularity of the normally smooth surface of the metaphysis at the distal end of the humerus (at the elbow).\nsynonyms :Irregular metaphyses of elbow; Irregular wide portion of elbow bone\n'}


{'id': 'HP_0003952', 'url': 'http://purl.obolibrary.org/obo/HP_0003952', 'lbl': 'Sclerotic foci of metaphyses of the elbow', 'desc': 'label: Sclerotic foci of metaphyses of the elbow\ndefinition : \nsynonyms :Vertical linear mixed lucent and sclerotic pattern of metaphyses\n'}


{'id': 'HP_0003953', 'url': 'http://purl.obolibrary.org/obo/HP_0003953', 'lbl': 'Absent forearm bone', 'desc': 'label: Absent forearm bone\ndefinition : Absence of one or more forearm bones associated with congenital failure of development.\nsynonyms :Absent forearm bone; Aplasia of the forearm bones\n'}


{'id': 'HP_0003954', 'url': 'http://purl.obolibrary.org/obo/HP_0003954', 'lbl': 'Angulated forearm bones', 'desc': 'label: Angulated forearm bones\ndefinition : \nsynonyms :Angulated forearm bones\n'}


{'id': 'HP_0003955', 'url': 'http://purl.obolibrary.org/obo/HP_0003955', 'lbl': 'Bone-in-a-bone appearance of forearm', 'desc': 'label: Bone-in-a-bone appearance of forearm\ndefinition : A descriptive term for a forearm bone that appears to have an additional bone within it on radiography.\nsynonyms :Bone-in-a-bone appearance of forearm\n'}


{'id': 'HP_0003956', 'url': 'http://purl.obolibrary.org/obo/HP_0003956', 'lbl': 'Bowed forearm bones', 'desc': 'label: Bowed forearm bones\ndefinition : A bending or abnormal curvature affecting either the radius, the ulna, or both.\nsynonyms :Bowed forearm bones\n'}


{'id': 'HP_0003957', 'url': 'http://purl.obolibrary.org/obo/HP_0003957', 'lbl': 'Cortical thickening of the forearm bones', 'desc': 'label: Cortical thickening of the forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003958', 'url': 'http://purl.obolibrary.org/obo/HP_0003958', 'lbl': 'Cross-fusion of the forearm bones', 'desc': 'label: Cross-fusion of the forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003959', 'url': 'http://purl.obolibrary.org/obo/HP_0003959', 'lbl': 'Deformed forearm bones', 'desc': 'label: Deformed forearm bones\ndefinition : \nsynonyms :Deformed forearm bones\n'}


{'id': 'HP_0003960', 'url': 'http://purl.obolibrary.org/obo/HP_0003960', 'lbl': 'Exostoses of the forearm bones', 'desc': 'label: Exostoses of the forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003961', 'url': 'http://purl.obolibrary.org/obo/HP_0003961', 'lbl': 'Fractured forearm bones', 'desc': 'label: Fractured forearm bones\ndefinition : Bone fracture in the radius, ulna, or wrist.\nsynonyms :Broken forearm; Fracture of the forearm; Fractured forearm bones\n'}


{'id': 'HP_0003963', 'url': 'http://purl.obolibrary.org/obo/HP_0003963', 'lbl': 'Lytic defects of the forearm bones', 'desc': 'label: Lytic defects of the forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003964', 'url': 'http://purl.obolibrary.org/obo/HP_0003964', 'lbl': 'Osteoporotic forearm bones', 'desc': 'label: Osteoporotic forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003965', 'url': 'http://purl.obolibrary.org/obo/HP_0003965', 'lbl': 'Pseudarthrosis of the forearm bones', 'desc': 'label: Pseudarthrosis of the forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003966', 'url': 'http://purl.obolibrary.org/obo/HP_0003966', 'lbl': 'Sclerotic foci in forearm bones', 'desc': 'label: Sclerotic foci in forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003967', 'url': 'http://purl.obolibrary.org/obo/HP_0003967', 'lbl': 'Sclerotic forearm bones', 'desc': 'label: Sclerotic forearm bones\ndefinition : \nsynonyms :Increased bone density of forearm bones\n'}


{'id': 'HP_0003969', 'url': 'http://purl.obolibrary.org/obo/HP_0003969', 'lbl': 'Slender forearm bones', 'desc': 'label: Slender forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003970', 'url': 'http://purl.obolibrary.org/obo/HP_0003970', 'lbl': 'Undermodelled forearm bones', 'desc': 'label: Undermodelled forearm bones\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003971', 'url': 'http://purl.obolibrary.org/obo/HP_0003971', 'lbl': 'Broad forearm bones', 'desc': 'label: Broad forearm bones\ndefinition : Abnormally wide bone of the skeleton of forearm.\nsynonyms :Broad forearm bones; Wide forearm bones\n'}


{'id': 'HP_0003973', 'url': 'http://purl.obolibrary.org/obo/HP_0003973', 'lbl': 'Wide radioulnar joints', 'desc': 'label: Wide radioulnar joints\ndefinition : \nsynonyms :Broad radioulnar joints\n'}


{'id': 'HP_0003974', 'url': 'http://purl.obolibrary.org/obo/HP_0003974', 'lbl': 'Absent radius', 'desc': 'label: Absent radius\ndefinition : Missing radius bone associated with congenital failure of development.\nsynonyms :Absent ossification/absence of radius; Aplasia of the radius; Missing outer large bone of forearm; Radial aplasia; absence of radius and ulna\n'}


{'id': 'HP_0003975', 'url': 'http://purl.obolibrary.org/obo/HP_0003975', 'lbl': 'obsolete Chevron-shaped/cone-shaped radius', 'desc': 'label: obsolete Chevron-shaped/cone-shaped radius\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003976', 'url': 'http://purl.obolibrary.org/obo/HP_0003976', 'lbl': 'Constricted radius', 'desc': 'label: Constricted radius\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003977', 'url': 'http://purl.obolibrary.org/obo/HP_0003977', 'lbl': 'Deformed radius', 'desc': 'label: Deformed radius\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003978', 'url': 'http://purl.obolibrary.org/obo/HP_0003978', 'lbl': 'Fractured radius', 'desc': 'label: Fractured radius\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003979', 'url': 'http://purl.obolibrary.org/obo/HP_0003979', 'lbl': 'Lytic defects of the radius', 'desc': 'label: Lytic defects of the radius\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003980', 'url': 'http://purl.obolibrary.org/obo/HP_0003980', 'lbl': 'Pseudarthrosis of the radius', 'desc': 'label: Pseudarthrosis of the radius\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003981', 'url': 'http://purl.obolibrary.org/obo/HP_0003981', 'lbl': 'Broad radius', 'desc': 'label: Broad radius\ndefinition : Increased width of the radius.\nsynonyms :Wide radius\n'}


{'id': 'HP_0003982', 'url': 'http://purl.obolibrary.org/obo/HP_0003982', 'lbl': 'Aplasia of the ulna', 'desc': 'label: Aplasia of the ulna\ndefinition : Missing ulna bone associated with congenital failure of development.\nsynonyms :Absent ossification/absent ulna; Absent ulna; Absent ulnae\n'}


{'id': 'HP_0003984', 'url': 'http://purl.obolibrary.org/obo/HP_0003984', 'lbl': 'Posteriorly dislocated ulna', 'desc': 'label: Posteriorly dislocated ulna\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003985', 'url': 'http://purl.obolibrary.org/obo/HP_0003985', 'lbl': 'Exostoses of the ulna', 'desc': 'label: Exostoses of the ulna\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003986', 'url': 'http://purl.obolibrary.org/obo/HP_0003986', 'lbl': 'Exostoses of the radius', 'desc': 'label: Exostoses of the radius\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003987', 'url': 'http://purl.obolibrary.org/obo/HP_0003987', 'lbl': 'Fractured ulna', 'desc': 'label: Fractured ulna\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003988', 'url': 'http://purl.obolibrary.org/obo/HP_0003988', 'lbl': 'Long ulna', 'desc': 'label: Long ulna\ndefinition : Increased length of the ulna.\nsynonyms :Disproportionately long ulnae\n'}


{'id': 'HP_0003989', 'url': 'http://purl.obolibrary.org/obo/HP_0003989', 'lbl': 'Notched ulna', 'desc': 'label: Notched ulna\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003990', 'url': 'http://purl.obolibrary.org/obo/HP_0003990', 'lbl': 'Pointed ulna', 'desc': 'label: Pointed ulna\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003991', 'url': 'http://purl.obolibrary.org/obo/HP_0003991', 'lbl': 'Osteosclerosis of the ulna', 'desc': 'label: Osteosclerosis of the ulna\ndefinition : Osteosclerosis (increased density related to increased bone mass) of the ulna.\nsynonyms :Sclerotic ulna\n'}


{'id': 'HP_0003992', 'url': 'http://purl.obolibrary.org/obo/HP_0003992', 'lbl': 'Slender ulna', 'desc': 'label: Slender ulna\ndefinition : Reduction in diameter of the ulna.\nsynonyms :\n'}


{'id': 'HP_0003993', 'url': 'http://purl.obolibrary.org/obo/HP_0003993', 'lbl': 'Broad ulna', 'desc': 'label: Broad ulna\ndefinition : Increased width of the ulna.\nsynonyms :Wide ulna\n'}


{'id': 'HP_0003994', 'url': 'http://purl.obolibrary.org/obo/HP_0003994', 'lbl': 'Dislocated wrist', 'desc': 'label: Dislocated wrist\ndefinition : An injury of the wrist with displacement of any of the eight carpal bones.\nsynonyms :Dislocated wrist; Dislocations of the wrists\n'}


{'id': 'HP_0003995', 'url': 'http://purl.obolibrary.org/obo/HP_0003995', 'lbl': 'Abnormality of the radial head', 'desc': 'label: Abnormality of the radial head\ndefinition : \nsynonyms :Deformity of radial heads\n'}


{'id': 'HP_0003996', 'url': 'http://purl.obolibrary.org/obo/HP_0003996', 'lbl': 'Flattened radial head', 'desc': 'label: Flattened radial head\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003997', 'url': 'http://purl.obolibrary.org/obo/HP_0003997', 'lbl': 'Hypoplastic radial head', 'desc': 'label: Hypoplastic radial head\ndefinition : \nsynonyms :Small radial head\n'}


{'id': 'HP_0003998', 'url': 'http://purl.obolibrary.org/obo/HP_0003998', 'lbl': 'Constricted radial neck', 'desc': 'label: Constricted radial neck\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0003999', 'url': 'http://purl.obolibrary.org/obo/HP_0003999', 'lbl': 'Abnormality of radial epiphyses', 'desc': 'label: Abnormality of radial epiphyses\ndefinition : \nsynonyms :Abnormality of radial epiphyseal plates\n'}


{'id': 'HP_0004000', 'url': 'http://purl.obolibrary.org/obo/HP_0004000', 'lbl': 'Cone-shaped distal radial epiphysis', 'desc': 'label: Cone-shaped distal radial epiphysis\ndefinition : The distal epiphysis (rounded portion of bone at the far end of the radius distal to the growth plate) has an abnormal cone-shaped appearance.\nsynonyms :Chevron-shaped distal radial epiphysis\n'}


{'id': 'HP_0004001', 'url': 'http://purl.obolibrary.org/obo/HP_0004001', 'lbl': 'Medially deficient radial epiphyses', 'desc': 'label: Medially deficient radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004002', 'url': 'http://purl.obolibrary.org/obo/HP_0004002', 'lbl': 'Flattened radial epiphyses', 'desc': 'label: Flattened radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004003', 'url': 'http://purl.obolibrary.org/obo/HP_0004003', 'lbl': 'Medially flattened radial epiphyses', 'desc': 'label: Medially flattened radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004004', 'url': 'http://purl.obolibrary.org/obo/HP_0004004', 'lbl': 'Irregular radial epiphyses', 'desc': 'label: Irregular radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004005', 'url': 'http://purl.obolibrary.org/obo/HP_0004005', 'lbl': 'Large radial epiphyses', 'desc': 'label: Large radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004006', 'url': 'http://purl.obolibrary.org/obo/HP_0004006', 'lbl': 'Round radial epiphyses', 'desc': 'label: Round radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004007', 'url': 'http://purl.obolibrary.org/obo/HP_0004007', 'lbl': 'Sclerotic radial epiphyses', 'desc': 'label: Sclerotic radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004008', 'url': 'http://purl.obolibrary.org/obo/HP_0004008', 'lbl': 'Sloping radial epiphyses', 'desc': 'label: Sloping radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004009', 'url': 'http://purl.obolibrary.org/obo/HP_0004009', 'lbl': 'Medially sloping radial epiphyses', 'desc': 'label: Medially sloping radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004010', 'url': 'http://purl.obolibrary.org/obo/HP_0004010', 'lbl': 'Small radial epiphyses', 'desc': 'label: Small radial epiphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004012', 'url': 'http://purl.obolibrary.org/obo/HP_0004012', 'lbl': 'Premature fusion of the radial epiphyseal plates', 'desc': 'label: Premature fusion of the radial epiphyseal plates\ndefinition : A premature fusion of the epiphyseal plates of the radius. Epiphyseal plates are located at the distal and proximal ends of the long bones, in this case of the radius and premature fusion will have an effect on the growh of the radial bone, inhibiting or at least disturbing the normal growth and development of the bone.\nsynonyms :\n'}


{'id': 'HP_0004013', 'url': 'http://purl.obolibrary.org/obo/HP_0004013', 'lbl': 'Medially fused radial epiphyseal plates', 'desc': 'label: Medially fused radial epiphyseal plates\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004014', 'url': 'http://purl.obolibrary.org/obo/HP_0004014', 'lbl': 'Broad radial epiphyseal plate', 'desc': 'label: Broad radial epiphyseal plate\ndefinition : Abnormal increase in width of the epiphyseal growth plate of the radius.\nsynonyms :Wide radial epiphyseal plates\n'}


{'id': 'HP_0004015', 'url': 'http://purl.obolibrary.org/obo/HP_0004015', 'lbl': 'Abnormal radial metaphysis morphology', 'desc': 'label: Abnormal radial metaphysis morphology\ndefinition : \nsynonyms :Abnormality of radial metaphyses\n'}


{'id': 'HP_0004016', 'url': 'http://purl.obolibrary.org/obo/HP_0004016', 'lbl': 'Cupped radial metaphyses', 'desc': 'label: Cupped radial metaphyses\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004017', 'url': 'http://purl.obolibrary.org/obo/HP_0004017', 'lbl': 'Exostoses of the radial metaphysis', 'desc': 'label: Exostoses of the radial metaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004018', 'url': 'http://purl.obolibrary.org/obo/HP_0004018', 'lbl': 'Flared radial metaphysis', 'desc': 'label: Flared radial metaphysis\ndefinition : The presence of a splayed (i.e.,flared) metaphyseal segment of the radius.\nsynonyms :Broadening of the distal radius\n'}


{'id': 'HP_0004019', 'url': 'http://purl.obolibrary.org/obo/HP_0004019', 'lbl': 'Radial metaphyseal irregularity', 'desc': 'label: Radial metaphyseal irregularity\ndefinition : Irregularity of the normally smooth surface of the metaphysis of the radius.\nsynonyms :Irregular radial metaphysis\n'}


{'id': 'HP_0004020', 'url': 'http://purl.obolibrary.org/obo/HP_0004020', 'lbl': 'Irregular ossification of the radial metaphysis', 'desc': 'label: Irregular ossification of the radial metaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004021', 'url': 'http://purl.obolibrary.org/obo/HP_0004021', 'lbl': 'Lytic defects of radial metaphysis', 'desc': 'label: Lytic defects of radial metaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004022', 'url': 'http://purl.obolibrary.org/obo/HP_0004022', 'lbl': 'Sclerotic radial metaphysis with longitudinal striations', 'desc': 'label: Sclerotic radial metaphysis with longitudinal striations\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004023', 'url': 'http://purl.obolibrary.org/obo/HP_0004023', 'lbl': 'Sloping radial metaphysis', 'desc': 'label: Sloping radial metaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004024', 'url': 'http://purl.obolibrary.org/obo/HP_0004024', 'lbl': 'Medially sloping radial metaphysis', 'desc': 'label: Medially sloping radial metaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004025', 'url': 'http://purl.obolibrary.org/obo/HP_0004025', 'lbl': 'Spurred radial metaphysis', 'desc': 'label: Spurred radial metaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004026', 'url': 'http://purl.obolibrary.org/obo/HP_0004026', 'lbl': 'Broad radial metaphysis', 'desc': 'label: Broad radial metaphysis\ndefinition : Increase in width (breadth) of the radial metaphysis.\nsynonyms :Wide radial metaphysis\n'}


{'id': 'HP_0004027', 'url': 'http://purl.obolibrary.org/obo/HP_0004027', 'lbl': 'Abnormality of radial diaphysis', 'desc': 'label: Abnormality of radial diaphysis\ndefinition : An anomaly of the radial diaphysis.\nsynonyms :\n'}


{'id': 'HP_0004028', 'url': 'http://purl.obolibrary.org/obo/HP_0004028', 'lbl': 'Spurs of radial diaphysis', 'desc': 'label: Spurs of radial diaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004029', 'url': 'http://purl.obolibrary.org/obo/HP_0004029', 'lbl': 'Lytic defects of radial diaphysis', 'desc': 'label: Lytic defects of radial diaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004030', 'url': 'http://purl.obolibrary.org/obo/HP_0004030', 'lbl': 'Patchy sclerosis of radial diaphysis', 'desc': 'label: Patchy sclerosis of radial diaphysis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004031', 'url': 'http://purl.obolibrary.org/obo/HP_0004031', 'lbl': 'Broad radial diaphysis', 'desc': 'label: Broad radial diaphysis\ndefinition : Increase in width of the diaphysis of radius.\nsynonyms :Wide radial diaphysis\n'}


{'id': 'HP_0004032', 'url': 'http://purl.obolibrary.org/obo/HP_0004032', 'lbl': 'Abnormal olecranon morphology', 'desc': 'label: Abnormal olecranon morphology\ndefinition : Any structural abnormality of the olecranon, a bony eminence of the proximal ulna.\nsynonyms :Abnormality of the olecranon\n'}


{'id': 'HP_0004033', 'url': 'http://purl.obolibrary.org/obo/HP_0004033', 'lbl': 'Curved olecranon', 'desc': 'label: Curved olecranon\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0004034', 'url': 'http://purl.obolibrary.org/obo/HP_0004034', 'lbl': 'Irregular olecranon', 'desc': 'label: Irregular olecranon\ndefinition : \nsynonyms :\n'}