{'id': 'HP_0034492', 'url': 'http://purl.obolibrary.org/obo/HP_0034492', 'lbl': 'Salpingitis', 'desc': 'label: Salpingitis\ndefinition : An inflammation of the fallopian tube.\nsynonyms :\n'}


{'id': 'HP_0034493', 'url': 'http://purl.obolibrary.org/obo/HP_0034493', 'lbl': 'Tubo-ovarian abscess', 'desc': 'label: Tubo-ovarian abscess\ndefinition : A tubo-ovarian abscess (TOA) is a complex infectious mass of the adnexa that forms as a sequela of pelvic inflammatory disease.\nsynonyms :\n'}


{'id': 'HP_0034494', 'url': 'http://purl.obolibrary.org/obo/HP_0034494', 'lbl': 'Opacified paranasal sinuses', 'desc': 'label: Opacified paranasal sinuses\ndefinition : White appearance (radio-opaqueness) of a paranasal sinus on radiography.\nsynonyms :Paranasal sinuses opacification; Paranasal sinuses opacified\n'}


{'id': 'HP_0034495', 'url': 'http://purl.obolibrary.org/obo/HP_0034495', 'lbl': 'Elevated brain glutamine level by MRS', 'desc': 'label: Elevated brain glutamine level by MRS\ndefinition : An increased in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :\n'}


{'id': 'HP_0034496', 'url': 'http://purl.obolibrary.org/obo/HP_0034496', 'lbl': 'Abnormal brain glutamine level by MRS', 'desc': 'label: Abnormal brain glutamine level by MRS\ndefinition : A deviation from normal in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS).\nsynonyms :\n'}


{'id': 'HP_0034497', 'url': 'http://purl.obolibrary.org/obo/HP_0034497', 'lbl': 'Increased urinary hexanoic acid level', 'desc': 'label: Increased urinary hexanoic acid level\ndefinition : An increased amount of hexanoic acid in the urine.\nsynonyms :\n'}


{'id': 'HP_0034498', 'url': 'http://purl.obolibrary.org/obo/HP_0034498', 'lbl': 'Hepatic focal nodular hyperplasia', 'desc': 'label: Hepatic focal nodular hyperplasia\ndefinition : Hepatic focal nodular hyperplasia (FNH) is a benign hepatic tumor. FNH develops within hepatic parenchymal tissue that is otherwise histologically normal. Macroscopically, the tumor is characterized by the presence of depressed, grayish-white scar, which is generally (but not always) located at the center of the lesion, with fibrous septa radiating outward, toward the periphery of the tumor. This stellate scar is found in only 50% of all FNH nodules, but its presence is regarded as pathognomonic. The lesion itself is usually lighter in color than the tissue that surrounds it, and it sometimes has a yellowish hue. FNH nodules are generally not capsulated; their margins are well defined, and they are sometimes lobulated.\nsynonyms :Focal nodular hyperplasia\n'}


{'id': 'HP_0034499', 'url': 'http://purl.obolibrary.org/obo/HP_0034499', 'lbl': 'Increased bone marrow iron', 'desc': 'label: Increased bone marrow iron\ndefinition : An increased amount of iron in the bone marrow.\nsynonyms :Bone marrow: iron stores increased\n'}


{'id': 'HP_0034500', 'url': 'http://purl.obolibrary.org/obo/HP_0034500', 'lbl': 'Glenoid fracture', 'desc': 'label: Glenoid fracture\ndefinition : A fracture of the glenoid fossa, a relatively shallow dish is located on the lateral scapula and is the socket portion of the shoulder joint that meets to articulate the humeral head.\nsynonyms :\n'}


{'id': 'HP_0034501', 'url': 'http://purl.obolibrary.org/obo/HP_0034501', 'lbl': 'Widened mediastinum', 'desc': 'label: Widened mediastinum\ndefinition : Abnormal increase in the width of the mediastinum, often defined as being greater than 6 to 8 cm.\nsynonyms :Mediastinal widening\n'}


{'id': 'HP_0034502', 'url': 'http://purl.obolibrary.org/obo/HP_0034502', 'lbl': 'Narrow mediastinum', 'desc': 'label: Narrow mediastinum\ndefinition : Abnormal decrease in the width of the mediastinum.\nsynonyms :\n'}


{'id': 'HP_0034503', 'url': 'http://purl.obolibrary.org/obo/HP_0034503', 'lbl': 'Ovarian torsion', 'desc': 'label: Ovarian torsion\ndefinition : Ovarian torsion is a twisting of the ligaments that support the adnexa, cutting off the blood flow to the ovary.\nsynonyms :\n'}


{'id': 'HP_0034504', 'url': 'http://purl.obolibrary.org/obo/HP_0034504', 'lbl': 'Septate gallbladder', 'desc': 'label: Septate gallbladder\ndefinition : Septate gallbladder is characterized by the presence of a septum that divides the gallbladder in two chambers. When the septum dividing the gallbladder lies longitudinally it is called bilobed gallbladder and when there is a transverse septum separating the fundus from the rest of the gallbladder it is called an hour-glass gallbladder.\nsynonyms :\n'}


{'id': 'HP_0034505', 'url': 'http://purl.obolibrary.org/obo/HP_0034505', 'lbl': 'Gallbladder wall thickening', 'desc': 'label: Gallbladder wall thickening\ndefinition : Abnormal increased in the thickness of the wall of the gallbladder.\nsynonyms :\n'}


{'id': 'HP_0034506', 'url': 'http://purl.obolibrary.org/obo/HP_0034506', 'lbl': 'Gallbladder enlargement', 'desc': 'label: Gallbladder enlargement\ndefinition : Abnormal increased in the thickness of the size of the gallbladder.\nsynonyms :Gallbladder enlarged\n'}


{'id': 'HP_0034507', 'url': 'http://purl.obolibrary.org/obo/HP_0034507', 'lbl': 'Gallbladder mass', 'desc': 'label: Gallbladder mass\ndefinition : An abnormal lesion or swelling seen on gallbladder imaging.\nsynonyms :\n'}


{'id': 'HP_0034508', 'url': 'http://purl.obolibrary.org/obo/HP_0034508', 'lbl': 'Fingerprint bodies', 'desc': 'label: Fingerprint bodies\ndefinition : Fingerprint bodies are inclusion bodies located at the periphery of the muscle fibers underneath the sarcolemma (subsarcolemmal), consisting of non-membrane-bound packed lamellae arranged in concentric patterns resembling fingerprints.\nsynonyms :Muscle biopsy: fingerprint bodies at periphery of muscle fibers\n'}


{'id': 'HP_0034509', 'url': 'http://purl.obolibrary.org/obo/HP_0034509', 'lbl': 'Spheroid bodies', 'desc': 'label: Spheroid bodies\ndefinition : An accumulation of myofilamentous material within individual muscle fibers, forming usually round but occasionally elongated bodies ranging from 2 to 15 pm in size. The so-called spheroid bodies stain green with the modified trichrome preparation and are mainly present in the periphery of type 1 muscle fibers, where they may occupy large sectors sharply demarcated from the remainder of the cross-sectioned muscle fiber.\nsynonyms :\n'}


{'id': 'HP_0034510', 'url': 'http://purl.obolibrary.org/obo/HP_0034510', 'lbl': 'Abnormal muscle tissue enzyme activity', 'desc': 'label: Abnormal muscle tissue enzyme activity\ndefinition : Any deviation from the normal activity of an enzyme in muscle tissue, usually measured in a muscle biopsy specimen.\nsynonyms :\n'}


{'id': 'HP_0034511', 'url': 'http://purl.obolibrary.org/obo/HP_0034511', 'lbl': 'Reduced muscle aconitase activity', 'desc': 'label: Reduced muscle aconitase activity\ndefinition : Diminished activity of the enzyne aconitase in muscle tissue.\nsynonyms :Muscle biopsy: aconitase deficiency\n'}


{'id': 'HP_0034512', 'url': 'http://purl.obolibrary.org/obo/HP_0034512', 'lbl': 'Transitional-cell carcinoma of the ureter', 'desc': 'label: Transitional-cell carcinoma of the ureter\ndefinition : A cancer of the ureter that most often arises in the distal third of the ureter and is often diagnosed during the sixth and seventh decades of life. The most common presentation is gross hematuria or flank pain.\nsynonyms :\n'}


{'id': 'HP_0034513', 'url': 'http://purl.obolibrary.org/obo/HP_0034513', 'lbl': 'Increased circulating Interferon-alpha concentration', 'desc': 'label: Increased circulating Interferon-alpha concentration\ndefinition : An elevation in the concentration of interferon alpha measured in the blood circulation.\nsynonyms :Interferon-alpha high in blood\n'}


{'id': 'HP_0034514', 'url': 'http://purl.obolibrary.org/obo/HP_0034514', 'lbl': 'Liver hamartoma', 'desc': 'label: Liver hamartoma\ndefinition : A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the liver.\nsynonyms :\n'}


{'id': 'HP_0034515', 'url': 'http://purl.obolibrary.org/obo/HP_0034515', 'lbl': 'Ameloblastoma', 'desc': 'label: Ameloblastoma\ndefinition : Ameloblastoma is a benign odontogenic tumor generally present in the jaw bone. The tumor originates from the residual epithelium of the tooth germ, epithelium of odontogenic cysts stratified squamous epithelium and epithelium of the enamel organ.\nsynonyms :\n'}


{'id': 'HP_0034516', 'url': 'http://purl.obolibrary.org/obo/HP_0034516', 'lbl': 'Ameliorated by ketogenic diet', 'desc': 'label: Ameliorated by ketogenic diet\ndefinition : Applies to a sign or symptom that is improved or made more bearable by following a ketogenic diet.\nsynonyms :Ketogenic diet improves symptoms\n'}


{'id': 'HP_0034517', 'url': 'http://purl.obolibrary.org/obo/HP_0034517', 'lbl': 'Pretibial hyperpigmentation', 'desc': 'label: Pretibial hyperpigmentation\ndefinition : Darkening of the area of skin that overlies the shin.\nsynonyms :\n'}


{'id': 'HP_0034518', 'url': 'http://purl.obolibrary.org/obo/HP_0034518', 'lbl': 'Gingival fragility', 'desc': 'label: Gingival fragility\ndefinition : Gums that are easily damaged.\nsynonyms :Gum fragility\n'}


{'id': 'HP_0034519', 'url': 'http://purl.obolibrary.org/obo/HP_0034519', 'lbl': 'Muscle fiber fuchsinophilic inclusion bodies', 'desc': 'label: Muscle fiber fuchsinophilic inclusion bodies\ndefinition : The presence of inclusion bodies within the cytoplasm of muscle cells that react positively with acid fuchsin.\nsynonyms :\n'}


{'id': 'HP_0034520', 'url': 'http://purl.obolibrary.org/obo/HP_0034520', 'lbl': 'Esophageal myenteric plexus degeneration', 'desc': 'label: Esophageal myenteric plexus degeneration\ndefinition : Deterioration of the cells of the myenteric plexus (also known as the Auerbach plexus) located between the layers of the muscular propria of the esophagus.\nsynonyms :\n'}


{'id': 'HP_0034521', 'url': 'http://purl.obolibrary.org/obo/HP_0034521', 'lbl': 'Periorificial hyperkeratosis', 'desc': 'label: Periorificial hyperkeratosis\ndefinition : Scaling and overgrowth of horny tissue of the skin surrounding body orifices (including peri-auricular, peri-oral, peri-anal areas.\nsynonyms :\n'}


{'id': 'HP_0034522', 'url': 'http://purl.obolibrary.org/obo/HP_0034522', 'lbl': 'Eosinophilic lymph node infiltration', 'desc': 'label: Eosinophilic lymph node infiltration\ndefinition : Presence of an elevated number of eosinophils in a lymph node (usually as demonstrated by lymph node biopsy).\nsynonyms :\n'}


{'id': 'HP_0034523', 'url': 'http://purl.obolibrary.org/obo/HP_0034523', 'lbl': 'Blood parasite', 'desc': 'label: Blood parasite\ndefinition : Detection of a parasitic organism in the blood stream. Blood parasites include malaria plasmodia, microfilaria species, trypanosomes (the causative agents of African sleeping sickness and South American Changas disease) and the causative agents of schistosomiasis of the bladder and the intestine.\nsynonyms :\n'}


{'id': 'HP_0034524', 'url': 'http://purl.obolibrary.org/obo/HP_0034524', 'lbl': 'Bloodstream trypomastigotes', 'desc': 'label: Bloodstream trypomastigotes\ndefinition : Presence of trypomastigote parasites in the blood stream. This finding can be demonstrated by the identification of trypomastigote parasites on peripheral blood smear.\nsynonyms :\n'}


{'id': 'HP_0034525', 'url': 'http://purl.obolibrary.org/obo/HP_0034525', 'lbl': 'Adamantinoma', 'desc': 'label: Adamantinoma\ndefinition : A primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns.\nsynonyms :\n'}


{'id': 'HP_0034526', 'url': 'http://purl.obolibrary.org/obo/HP_0034526', 'lbl': 'Abnormal enzyme activity in muscle tissue', 'desc': 'label: Abnormal enzyme activity in muscle tissue\ndefinition : Deviation from the normal activity of an enzyme in muscle tissue.\nsynonyms :\n'}


{'id': 'HP_0034527', 'url': 'http://purl.obolibrary.org/obo/HP_0034527', 'lbl': 'Reduced muscle phosphoglycerate kinase activity', 'desc': 'label: Reduced muscle phosphoglycerate kinase activity\ndefinition : Reduced activity of phosphoglycerate kinase (PGK) in muscle tissue. PGK is a glycolytic enzyme that catalyses one of the two ATP-producing reactions in the glycolytic pathway, through the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.\nsynonyms :\n'}


{'id': 'HP_0034528', 'url': 'http://purl.obolibrary.org/obo/HP_0034528', 'lbl': 'Reduced fibroblast type III procollagen synthesis', 'desc': 'label: Reduced fibroblast type III procollagen synthesis\ndefinition : Diminished production of type III procollagen by cultured skin fibroblasts.\nsynonyms :Type III procollagen synthesis by fibroblasts low\n'}


{'id': 'HP_0034529', 'url': 'http://purl.obolibrary.org/obo/HP_0034529', 'lbl': 'Reduced muscle myoadenylate deaminase activity', 'desc': 'label: Reduced muscle myoadenylate deaminase activity\ndefinition : Diminished activity of the enzyme myoadenylate deaminase. Myoadenylate deaminase is the muscle isoform of adenosine monophosphate (AMP) deaminase and catalyzes the deamination of AMP to inosine monophosphate and ammonia.\nsynonyms :Muscle biopsy: myoadenylate deaminase low\n'}


{'id': 'HP_0034530', 'url': 'http://purl.obolibrary.org/obo/HP_0034530', 'lbl': 'Bent long bone', 'desc': 'label: Bent long bone\ndefinition : A developmental defect of a long bone, such as the femur or the humerus, characterized by a sharply curve deviation located in the metaphysis (shaft) of the bone.\nsynonyms :\n'}


{'id': 'HP_0034531', 'url': 'http://purl.obolibrary.org/obo/HP_0034531', 'lbl': 'Tracheal rupture', 'desc': 'label: Tracheal rupture\ndefinition : A break or tear in the trachea.\nsynonyms :\n'}


{'id': 'HP_0034532', 'url': 'http://purl.obolibrary.org/obo/HP_0034532', 'lbl': 'Increased myocardial glycogen content', 'desc': 'label: Increased myocardial glycogen content\ndefinition : Elevated amount of glycogen in the myocardium.\nsynonyms :Increased glycogen in myocardium\n'}


{'id': 'HP_0034533', 'url': 'http://purl.obolibrary.org/obo/HP_0034533', 'lbl': 'Triggered by monoamine oxidase inhibitor', 'desc': 'label: Triggered by monoamine oxidase inhibitor\ndefinition : Applies to a sign or symptom that is provoked or brought about by exposure to a monoamine oxidase inhibitor.\nsynonyms :MAO inhibitors trigger attacks; Triggered by MAO inhibitor\n'}


{'id': 'HP_0034534', 'url': 'http://purl.obolibrary.org/obo/HP_0034534', 'lbl': 'Triggered by serotonin reuptake inhibitor', 'desc': 'label: Triggered by serotonin reuptake inhibitor\ndefinition : Applies to a sign or symptom that is provoked or brought about by exposure to a serotonin reuptake inhibitor.\nsynonyms :Serotonin uptake inhibitors trigger attacks\n'}


{'id': 'HP_0034535', 'url': 'http://purl.obolibrary.org/obo/HP_0034535', 'lbl': 'Ameliorated by acetazolamide', 'desc': 'label: Ameliorated by acetazolamide\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with acetazolamide.\nsynonyms :Acetazolamide relieves attacks\n'}


{'id': 'HP_0034536', 'url': 'http://purl.obolibrary.org/obo/HP_0034536', 'lbl': 'Ameliorated by exposure to medication', 'desc': 'label: Ameliorated by exposure to medication\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with a medication. Terms in this subhierarchy are intended to be used for cases in which the fact that a manifestation of a disease responds to a specific treatment can be used in the differential diagnosis.\nsynonyms :\n'}


{'id': 'HP_0034537', 'url': 'http://purl.obolibrary.org/obo/HP_0034537', 'lbl': 'Ameliorated by vitamin B12', 'desc': 'label: Ameliorated by vitamin B12\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with vitamin B12.\nsynonyms :Vitamin B12 treatment produces improvement\n'}


{'id': 'HP_0034538', 'url': 'http://purl.obolibrary.org/obo/HP_0034538', 'lbl': 'Ameliorated by thiamine', 'desc': 'label: Ameliorated by thiamine\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with thiamine.\nsynonyms :Thiamine: positive response\n'}


{'id': 'HP_0034539', 'url': 'http://purl.obolibrary.org/obo/HP_0034539', 'lbl': 'Ameliorated by dantrolene', 'desc': 'label: Ameliorated by dantrolene\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with dantrolene.\nsynonyms :Dantrolene reduces symptoms\n'}


{'id': 'HP_0034540', 'url': 'http://purl.obolibrary.org/obo/HP_0034540', 'lbl': 'Ameliorated by biotin', 'desc': 'label: Ameliorated by biotin\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with biotin.\nsynonyms :Biotin supplementation produces improvement\n'}


{'id': 'HP_0034541', 'url': 'http://purl.obolibrary.org/obo/HP_0034541', 'lbl': 'Reduced bone-marrow megakaryocyte size', 'desc': 'label: Reduced bone-marrow megakaryocyte size\ndefinition : Decreased in average size (diameter) of megakaryocytes in the bone marrow. Megakaryocyte diameter can be assessed as using automated cellular imaging systems.\nsynonyms :\n'}


{'id': 'HP_0034542', 'url': 'http://purl.obolibrary.org/obo/HP_0034542', 'lbl': 'Hairshafts with longitudinal grooves', 'desc': 'label: Hairshafts with longitudinal grooves\ndefinition : Long narrow depressions running lengthwise in hairshafts. This feature can be appreciated by scanning electron microsopy.\nsynonyms :\n'}


{'id': 'HP_0034543', 'url': 'http://purl.obolibrary.org/obo/HP_0034543', 'lbl': 'Mycobacterium bacteremia', 'desc': 'label: Mycobacterium bacteremia\ndefinition : Presence of viable mycobacteria in the blood.\nsynonyms :Mycobacterium present on blood culture\n'}


{'id': 'HP_0034544', 'url': 'http://purl.obolibrary.org/obo/HP_0034544', 'lbl': 'Decreased delta-aminolevulinate dehydratase activity', 'desc': 'label: Decreased delta-aminolevulinate dehydratase activity\ndefinition : Reduced activity of the enzyme delta-aminolevulinate dehydratase. The enzyme is active in erythrocytes.\nsynonyms :Delta-aminolevulinate dehydratase activity low; Delta-aminolevulinate dehydratase deficiency\n'}


{'id': 'HP_0034545', 'url': 'http://purl.obolibrary.org/obo/HP_0034545', 'lbl': 'Elevated circulating pancreatic secretory trypsin inhibitor activity', 'desc': 'label: Elevated circulating pancreatic secretory trypsin inhibitor activity\ndefinition : Increased activity of the enzyme pancreatic secretory trypsin inhibitor in the blood circulation.\nsynonyms :Elevated circulating SPINK1 activity; Elevated circulating serine protease inhibitor Kazal type I\n'}


{'id': 'HP_0034546', 'url': 'http://purl.obolibrary.org/obo/HP_0034546', 'lbl': 'Presence of uterus in 46,XY individual', 'desc': 'label: Presence of uterus in 46,XY individual\ndefinition : A developmental anomaly in which an individual with an X chromosome and a Y chromosome (usually 46,XY) has a uterus. The uterus and Fallopian tubes are derived from the Müllerian duct and thus this phenotype is generally also associated with the presence of Fallopian tubes.\nsynonyms :\n'}


{'id': 'HP_0034547', 'url': 'http://purl.obolibrary.org/obo/HP_0034547', 'lbl': 'Intraluminal meconium calcification', 'desc': 'label: Intraluminal meconium calcification\ndefinition : Deposition of calcium in meconium present in the internal cavity of the fetal bowel. This manifestation may be the result of any distal intestinal obstruction.\nsynonyms :\n'}


{'id': 'HP_0034548', 'url': 'http://purl.obolibrary.org/obo/HP_0034548', 'lbl': 'Portal vein hypoplasia', 'desc': 'label: Portal vein hypoplasia\ndefinition : A developmental defect characterized by underdevelopment of hte portal vein.\nsynonyms :Hypoplasia of the portal veins\n'}


{'id': 'HP_0034549', 'url': 'http://purl.obolibrary.org/obo/HP_0034549', 'lbl': 'Adrenal leiomyoma', 'desc': 'label: Adrenal leiomyoma\ndefinition : Adrenal leiomyoma is a rare, benign solid tumor that develops from the smooth muscle of the adrenal vein and its tributaries\nsynonyms :\n'}


{'id': 'HP_0034550', 'url': 'http://purl.obolibrary.org/obo/HP_0034550', 'lbl': 'Small intestinal lymphoplasmacytic infiltrate', 'desc': 'label: Small intestinal lymphoplasmacytic infiltrate\ndefinition : Infiltration of the wall of the small intestine by lymphocytes and mature plasma cells.\nsynonyms :\n'}


{'id': 'HP_0034551', 'url': 'http://purl.obolibrary.org/obo/HP_0034551', 'lbl': 'Triggered by neuroleptic medication', 'desc': 'label: Triggered by neuroleptic medication\ndefinition : Applies to a sign or symptom that is provoked or brought about by exposure to neuroleptic (also known as antipsychotic) medication.\nsynonyms :Triggered by antipsychotic medication\n'}


{'id': 'HP_0034552', 'url': 'http://purl.obolibrary.org/obo/HP_0034552', 'lbl': 'Abnormal peroxisomal morphology', 'desc': 'label: Abnormal peroxisomal morphology\ndefinition : Structural anomaly of peroxisomes, which are small, membrane-enclosed metabolic organelles with roles in the metabolism of complex lipids and reactive ionic species.\nsynonyms :\n'}


{'id': 'HP_0034553', 'url': 'http://purl.obolibrary.org/obo/HP_0034553', 'lbl': 'Absence of peroxisomes', 'desc': 'label: Absence of peroxisomes\ndefinition : Lack of observable peroxisomes. This feature can be observed by immunohistochemical staining of cultured cells (such as fibroblasts) or by electronmicroscopy.\nsynonyms :\n'}


{'id': 'HP_0034554', 'url': 'http://purl.obolibrary.org/obo/HP_0034554', 'lbl': 'Paucity of peroxisomes', 'desc': 'label: Paucity of peroxisomes\ndefinition : Reduced number of observable peroxisomes per cell. This feature can be observed by immunohistochemical staining of cultured cells (such as fibroblasts) or by electronmicroscopy.\nsynonyms :\n'}


{'id': 'HP_0034555', 'url': 'http://purl.obolibrary.org/obo/HP_0034555', 'lbl': 'Reduced sulfide:quinone oxidoreductase activity', 'desc': 'label: Reduced sulfide:quinone oxidoreductase activity\ndefinition : Reduced activity of the enzyme sulfide:quinone oxidoreductase, which typically is measured in a biopsy specimen from liver or muscle.\nsynonyms :\n'}


{'id': 'HP_0034556', 'url': 'http://purl.obolibrary.org/obo/HP_0034556', 'lbl': 'Deficit at segmental level', 'desc': 'label: Deficit at segmental level\ndefinition : Refers to distribution of neurological deficits that corresponds to a deficit of a specific spinal segment and all segments below it.\nsynonyms :\n'}


{'id': 'HP_0034557', 'url': 'http://purl.obolibrary.org/obo/HP_0034557', 'lbl': 'Rhabdoid tumor', 'desc': 'label: Rhabdoid tumor\ndefinition : Rhabdoid tumors are rare aggressive malignancies in infants and young children with a poor prognosis. The most common anatomic localizations are the central nervous system, the kidneys, and other soft tissues.\nsynonyms :\n'}


{'id': 'HP_0034558', 'url': 'http://purl.obolibrary.org/obo/HP_0034558', 'lbl': 'Rhabdoid tumor of the ovary', 'desc': 'label: Rhabdoid tumor of the ovary\ndefinition : A highly aggressive, extremely rare neoplasm of the ovary that is usually seen in children. The term rhabdoid is used because the tumor cells resemble rhabdomyoblasts but lack myogenic markers.\nsynonyms :\n'}


{'id': 'HP_0034559', 'url': 'http://purl.obolibrary.org/obo/HP_0034559', 'lbl': 'Cardiac rhabdoid tumor', 'desc': 'label: Cardiac rhabdoid tumor\ndefinition : A rare and aggressive neoplasms developing mainly in the kidney but also in cerebral and extra-cerebral tissues and rarely in the heart. Histologically, rhabdoid renal and extrarenal tumors share common characteristics. The cells are polygonal, with eccentric, vesicular nuclei and prominent nucleoli, eosinophilic cytoplasmic inclusions. The tumors have an infiltrative growth pattern, necrosis, and high proliferative index. The immunohistochemistry tools of investigation facilitate differential diagnosis by showing loss of INI-1 expression, usually accompanied by germline mutations of the SMARCB1 gene. When INI-1 is still expressed in the affected tissues, a rhabdoid tumor with SMARCA4 mutations should be considered.\nsynonyms :\n'}


{'id': 'HP_0034560', 'url': 'http://purl.obolibrary.org/obo/HP_0034560', 'lbl': 'Malignant rhabdoid tumor of the bladder', 'desc': 'label: Malignant rhabdoid tumor of the bladder\ndefinition : A rhabdoid tumor (a rare aggressive malignancies in infants and young children with a poor prognosis) originating in the urinary bladder.\nsynonyms :\n'}


{'id': 'HP_0034561', 'url': 'http://purl.obolibrary.org/obo/HP_0034561', 'lbl': 'Malignant rhabdoid tumor of liver', 'desc': 'label: Malignant rhabdoid tumor of liver\ndefinition : A malginant rhabdoid tumor (MRT) originating in the liver. MRT are best characterized by the presence of round or polygonal cells with abundant eosinophilic cytoplasm, typical eosinophilic perinuclear inclusions, vesicular nuclei and prominent nucleoli. Immunohistochemical expression of vimentin and epithelial markers and lack of staining for S-100, myoglobin and desmin are commonly found, but are non-specific.\nsynonyms :\n'}


{'id': 'HP_0034562', 'url': 'http://purl.obolibrary.org/obo/HP_0034562', 'lbl': 'Malignant rhabdoid tumor of muscle', 'desc': 'label: Malignant rhabdoid tumor of muscle\ndefinition : A malginant rhabdoid tumor (MRT) originating in muscle tissue.\nsynonyms :\n'}


{'id': 'HP_0034563', 'url': 'http://purl.obolibrary.org/obo/HP_0034563', 'lbl': 'Neck teratoma', 'desc': 'label: Neck teratoma\ndefinition : A teratoma located in the neck.\nsynonyms :\n'}


{'id': 'HP_0034564', 'url': 'http://purl.obolibrary.org/obo/HP_0034564', 'lbl': 'Kidney teratoma', 'desc': 'label: Kidney teratoma\ndefinition : A teratoma located in a kidney.\nsynonyms :\n'}


{'id': 'HP_0034565', 'url': 'http://purl.obolibrary.org/obo/HP_0034565', 'lbl': 'Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level', 'desc': 'label: Elevated urinary 5-amino-4-imidazolecarboxamide-riboside level\ndefinition : Increased amount of 5-amino-4-imidazolecarboxamide(AICA)-riboside in the urine. AICA-riboside is the dephosphorylated counterpart of AICAR, an intermediate of de novo purine biosynthesis.\nsynonyms :\n'}


{'id': 'HP_0034566', 'url': 'http://purl.obolibrary.org/obo/HP_0034566', 'lbl': 'Aplasia of posterior communicating artery', 'desc': 'label: Aplasia of posterior communicating artery\ndefinition : A developmental anomnaly characterized by the lack of development of the posterior communicating artery.\nsynonyms :Absence of both posterior communicating arteries\n'}


{'id': 'HP_0034567', 'url': 'http://purl.obolibrary.org/obo/HP_0034567', 'lbl': 'Optic pit', 'desc': 'label: Optic pit\ndefinition : A developmental anomaloy characterized by congenital excavation of the optic nerve head.\nsynonyms :Optic disc pit; Optic nerve pit\n'}


{'id': 'HP_0034568', 'url': 'http://purl.obolibrary.org/obo/HP_0034568', 'lbl': 'Ameliorated by naloxone', 'desc': 'label: Ameliorated by naloxone\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with naloxone, an opioid antagonist.\nsynonyms :\n'}


{'id': 'HP_0034569', 'url': 'http://purl.obolibrary.org/obo/HP_0034569', 'lbl': 'Ameliorated by pyridoxal phosphate', 'desc': 'label: Ameliorated by pyridoxal phosphate\ndefinition : Applies to a sign or symptom that is improved or made more bearable by ingestion of pyridoxal phosphate (activated vitamin B6).\nsynonyms :\n'}


{'id': 'HP_0034570', 'url': 'http://purl.obolibrary.org/obo/HP_0034570', 'lbl': 'Thickened intrahepatic portal venules', 'desc': 'label: Thickened intrahepatic portal venules\ndefinition : Increased width of the vascular wall of portal venules within the liver.\nsynonyms :\n'}


{'id': 'HP_0034571', 'url': 'http://purl.obolibrary.org/obo/HP_0034571', 'lbl': 'Ovarian fibrosis', 'desc': 'label: Ovarian fibrosis\ndefinition : Excessive proliferation of fibroblasts and deposition of extracellular matrix within the ovary.\nsynonyms :\n'}


{'id': 'HP_0034572', 'url': 'http://purl.obolibrary.org/obo/HP_0034572', 'lbl': 'Pigment incontinence', 'desc': "label: Pigment incontinence\ndefinition : A process in which melanosomes (melanin granules) are deposited in the dermis. The dermal melanosomes are observed to be mainly in macrophages. This phenomenon of pigmentary incontinence usually follows an inflammatory process with the basic feature of basal cell damage, such as in lichen planus, lupus erythematosus, Riehl's melanosis, incontinentia pigmenti (Bloch-Sulzberger), and fixed drug eruption. Incontinence of pigment, or dropping off of epidermal melanin into the dermis, frequently produces a clinically recognizable and characteristic slate-gray pigmentation.\nsynonyms :Pigmentary incontinence in papillary dermis\n"}


{'id': 'HP_0034573', 'url': 'http://purl.obolibrary.org/obo/HP_0034573', 'lbl': 'Abnormal epidermal protein expression', 'desc': 'label: Abnormal epidermal protein expression\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034574', 'url': 'http://purl.obolibrary.org/obo/HP_0034574', 'lbl': 'Reduced epidermal keratin 10 protein expression', 'desc': 'label: Reduced epidermal keratin 10 protein expression\ndefinition : Lower than normal amount of keratin 10 in the epidermis.\nsynonyms :\n'}


{'id': 'HP_0034575', 'url': 'http://purl.obolibrary.org/obo/HP_0034575', 'lbl': 'Reduced epidermal collagen IV protein expression', 'desc': 'label: Reduced epidermal collagen IV protein expression\ndefinition : \nsynonyms :Skin biopsy: collagen IV antibody staining abnormal or absent\n'}


{'id': 'HP_0034576', 'url': 'http://purl.obolibrary.org/obo/HP_0034576', 'lbl': 'Reduced epidermal bullous pemphigoid antigen 1 protein expression', 'desc': 'label: Reduced epidermal bullous pemphigoid antigen 1 protein expression\ndefinition : Lower than normal amount of bullous pemphigoid antigen 1 (BP230) in the epidermis.\nsynonyms :Skin biopsy: BPAG1-e antibody staining abnormal or absent\n'}


{'id': 'HP_0034577', 'url': 'http://purl.obolibrary.org/obo/HP_0034577', 'lbl': 'Reduced epidermal collagen VII protein expression', 'desc': 'label: Reduced epidermal collagen VII protein expression\ndefinition : \nsynonyms :Skin biopsy: collagen VII antibody staining abnormal or absent\n'}


{'id': 'HP_0034578', 'url': 'http://purl.obolibrary.org/obo/HP_0034578', 'lbl': 'Reduced epidermal collagen XVII protein expression', 'desc': 'label: Reduced epidermal collagen XVII protein expression\ndefinition : \nsynonyms :Skin biopsy: collagen XVII antibody staining abnormal or absent\n'}


{'id': 'HP_0034579', 'url': 'http://purl.obolibrary.org/obo/HP_0034579', 'lbl': 'Reduced epidermal integrin alpha6beta4 protein expression', 'desc': 'label: Reduced epidermal integrin alpha6beta4 protein expression\ndefinition : \nsynonyms :Skin biopsy: integrin alpha6beta4 antibody staining abnormal or absent\n'}


{'id': 'HP_0034580', 'url': 'http://purl.obolibrary.org/obo/HP_0034580', 'lbl': 'Reduced epidermal plectin protein expression', 'desc': 'label: Reduced epidermal plectin protein expression\ndefinition : \nsynonyms :Skin biopsy: plectin antibody staining abnormal or absent\n'}


{'id': 'HP_0034581', 'url': 'http://purl.obolibrary.org/obo/HP_0034581', 'lbl': 'Bloodstream Trypanosoma cruzi', 'desc': 'label: Bloodstream Trypanosoma cruzi\ndefinition : Presence of Trypanosoma cruzi in the blood stream. Trypanosoma cruzii is the etiological agent of Chagas disease.\nsynonyms :Trypanosoma cruzi present on peripheral blood smear\n'}


{'id': 'HP_0034582', 'url': 'http://purl.obolibrary.org/obo/HP_0034582', 'lbl': 'Abnormal lymph node cell composition', 'desc': 'label: Abnormal lymph node cell composition\ndefinition : A deviation from the normal distribution of cell types or their relative proprotions in a lymph node.\nsynonyms :\n'}


{'id': 'HP_0034583', 'url': 'http://purl.obolibrary.org/obo/HP_0034583', 'lbl': 'Lipid-laden lymph node macrophages', 'desc': 'label: Lipid-laden lymph node macrophages\ndefinition : Lymph node with increased numbers of macrophages heavily laden with lipids.\nsynonyms :\n'}


{'id': 'HP_0034584', 'url': 'http://purl.obolibrary.org/obo/HP_0034584', 'lbl': 'Abnormal pancreatic acinus morphology', 'desc': 'label: Abnormal pancreatic acinus morphology\ndefinition : Structural anomal of pancreatic acinus.\nsynonyms :\n'}


{'id': 'HP_0034585', 'url': 'http://purl.obolibrary.org/obo/HP_0034585', 'lbl': 'Cochlear nerve hypoplasia', 'desc': 'label: Cochlear nerve hypoplasia\ndefinition : A developmental defect characterized by underdevelopment of the cochlear nerve.\nsynonyms :\n'}


{'id': 'HP_0034586', 'url': 'http://purl.obolibrary.org/obo/HP_0034586', 'lbl': 'Glutathionuria', 'desc': 'label: Glutathionuria\ndefinition : Level of glutathione in the urine above the upper limit of normal.\nsynonyms :Glutathione high in urine\n'}


{'id': 'HP_0034587', 'url': 'http://purl.obolibrary.org/obo/HP_0034587', 'lbl': 'Nevus psiloliparus', 'desc': 'label: Nevus psiloliparus\ndefinition : Nevus psiloliparus is a rare fatty tissue nevus that is a marker for encephalocraniocutaneous lipomatosis, a neurocutaneous syndrome with ocular and central nervous system anomalies. Clinically, nevus psiloliparus is often described as a congenital alopecia and appears as an irregularly shaped, circumscribed area of alopecia on the scalp. Histopathology demonstrates a near-complete absence of mature hair follicles with preservation of arrector pili muscles and mature adipocytes within the dermis.\nsynonyms :\n'}


{'id': 'HP_0034588', 'url': 'http://purl.obolibrary.org/obo/HP_0034588', 'lbl': 'Crypt hyperplasia', 'desc': 'label: Crypt hyperplasia\ndefinition : Crypt hyperplasia denotes elongation of the length of the crypts of Lieberkuhn, a process that initially precedes villous atrophy. Elongation may be caused by expansion of the lamina propria as a result of the proliferation of stromal cells, an influx of inflammatory cells and tissue remodelling.\nsynonyms :\n'}


{'id': 'HP_0034589', 'url': 'http://purl.obolibrary.org/obo/HP_0034589', 'lbl': 'Increased circulating dehydroepiandrosterone-sulfate concentration', 'desc': 'label: Increased circulating dehydroepiandrosterone-sulfate concentration\ndefinition : Increased circulating concentration of dehydroepiandrosterone-sulfate, a precursor of testosterone and estrogen.\nsynonyms :\n'}


{'id': 'HP_0034590', 'url': 'http://purl.obolibrary.org/obo/HP_0034590', 'lbl': 'Abnormal circulating thyroxine-binding globulin concentration', 'desc': 'label: Abnormal circulating thyroxine-binding globulin concentration\ndefinition : Any deviation from the normal concentration of thyroxine-binding globulin (TBG) in the blood circulation.\nsynonyms :\n'}


{'id': 'HP_0034591', 'url': 'http://purl.obolibrary.org/obo/HP_0034591', 'lbl': 'Decreased circulating thyroxine-binding globulin concentration', 'desc': 'label: Decreased circulating thyroxine-binding globulin concentration\ndefinition : A reduction from the normal concentration of thyroxine-binding globulin (TBG) in the blood circulation.\nsynonyms :Thyroxine-binding globulin low in blood\n'}


{'id': 'HP_0034592', 'url': 'http://purl.obolibrary.org/obo/HP_0034592', 'lbl': 'Elevated circulating beta-aminoisobutyric acid concentration', 'desc': 'label: Elevated circulating beta-aminoisobutyric acid concentration\ndefinition : An increased concentration of beta-aminoisobutyric acid in the blood circulation.\nsynonyms :Beta-aminoisobutyric acid high in blood\n'}


{'id': 'HP_0034593', 'url': 'http://purl.obolibrary.org/obo/HP_0034593', 'lbl': 'Elevated circulating dihydrouracil concentration', 'desc': 'label: Elevated circulating dihydrouracil concentration\ndefinition : An increased concentration of dihydrouracil in the blood circulation. Dihydrouracil is an intermediate in the catabolism of uracil that is also known as 5,6-dihydrouracil.\nsynonyms :Dihydrouracil high in blood; Elevated circulating 5,6-dihydrouracil concentration\n'}


{'id': 'HP_0034594', 'url': 'http://purl.obolibrary.org/obo/HP_0034594', 'lbl': 'Elevated circulating dihydrothymine concentration', 'desc': 'label: Elevated circulating dihydrothymine concentration\ndefinition : An increased concentration of dihydrothymine in the blood circulation. Dihydrouracil is an intermediate in the catabolism of thymine.\nsynonyms :Dihydrothymine high in blood\n'}


{'id': 'HP_0034595', 'url': 'http://purl.obolibrary.org/obo/HP_0034595', 'lbl': 'Elevated circulating N-carbamyl-beta-alanine concentration', 'desc': 'label: Elevated circulating N-carbamyl-beta-alanine concentration\ndefinition : An increased concentrationof N-carbamyl-beta-alanine in the blood circulation.\nsynonyms :N-carbamyl-beta-aminoisobutyric acid high in blood\n'}


{'id': 'HP_0034596', 'url': 'http://purl.obolibrary.org/obo/HP_0034596', 'lbl': 'Elevated ciculating 5-hydroxymethyluracil concentration', 'desc': 'label: Elevated ciculating 5-hydroxymethyluracil concentration\ndefinition : An increased concentration of 5-hydroxymethyluracil in the blood circulation.\nsynonyms :5-hydroxymethyluracil high in blood\n'}


{'id': 'HP_0034597', 'url': 'http://purl.obolibrary.org/obo/HP_0034597', 'lbl': 'Decreased CSF creatinine concentration', 'desc': 'label: Decreased CSF creatinine concentration\ndefinition : Concentration of creatinine in the cerebrrospinal fluid below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034598', 'url': 'http://purl.obolibrary.org/obo/HP_0034598', 'lbl': 'Elevated urinary creatine level', 'desc': 'label: Elevated urinary creatine level\ndefinition : An increased amount of creatine in the urine.\nsynonyms :Creatine high in urine\n'}


{'id': 'HP_0034599', 'url': 'http://purl.obolibrary.org/obo/HP_0034599', 'lbl': 'Decreased circulating biotin concentration', 'desc': 'label: Decreased circulating biotin concentration\ndefinition : Concentration of biotin in the blood circulation below the lower limit of normal.\nsynonyms :Biotin low in blood\n'}


{'id': 'HP_0034600', 'url': 'http://purl.obolibrary.org/obo/HP_0034600', 'lbl': 'Elevated circulating thrombopoietin concentration', 'desc': 'label: Elevated circulating thrombopoietin concentration\ndefinition : Concentration of thrombopoietin in the blood circulation above the upper limit of normal. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney that stimulates the production and differentiation of megakaryocytes.\nsynonyms :Thrombopoietin high in blood\n'}


{'id': 'HP_0034601', 'url': 'http://purl.obolibrary.org/obo/HP_0034601', 'lbl': 'Decreased circulating C1q concentration', 'desc': 'label: Decreased circulating C1q concentration\ndefinition : Concentration or activity of the C1q protein in the blood circulation below the lower limit of normal. C1q is the first component of the classical pathway and is composed of the C1qA chain, C1qB chain, and C1qC chain, which are encoded by C1qA, C1qB, and C1qC genes.\nsynonyms :\n'}


{'id': 'HP_0034602', 'url': 'http://purl.obolibrary.org/obo/HP_0034602', 'lbl': 'Decreased circulating apolipoprotein A-II concentration', 'desc': 'label: Decreased circulating apolipoprotein A-II concentration\ndefinition : Concentration of apolipoprotein A-II below the lower limit of normal.\nsynonyms :Apolipoprotein A-II low in blood\n'}


{'id': 'HP_0034603', 'url': 'http://purl.obolibrary.org/obo/HP_0034603', 'lbl': 'Elevated circulating CA19-9 concentration', 'desc': 'label: Elevated circulating CA19-9 concentration\ndefinition : Concentration of CA19-9 above the upper limit of normal.\nsynonyms :Elevated circulating cancer antigen 19-9 concentration; Elevated circulating carbohydrate antigen 19-9 concentration; Elevated circulating sialylated Lewis a antigen concentration\n'}


{'id': 'HP_0034604', 'url': 'http://purl.obolibrary.org/obo/HP_0034604', 'lbl': 'Elevated circulating DOPA concentration', 'desc': 'label: Elevated circulating DOPA concentration\ndefinition : Concentration of DOPA (3,4-dihydroxyphenylalanine) in the blood circulation above the upper limit of normal.\nsynonyms :DOPA high in blood; Elevated circulating 3,4-dihydroxyphenylalanine concentration\n'}


{'id': 'HP_0034605', 'url': 'http://purl.obolibrary.org/obo/HP_0034605', 'lbl': 'Elevated CSF DOPA concentration', 'desc': 'label: Elevated CSF DOPA concentration\ndefinition : Concentration of DOPA (3,4-dihydroxyphenylalanine) in the cerebrospinal fluid above the upper limit of normal.\nsynonyms :Elevated CSF 3,4-dihydroxyphenylalanine concentration\n'}


{'id': 'HP_0034606', 'url': 'http://purl.obolibrary.org/obo/HP_0034606', 'lbl': 'Elevated circulating porphyrin concentration', 'desc': 'label: Elevated circulating porphyrin concentration\ndefinition : Concentration of porphyrins or of a specific porphryin above the upper limit of normal. The most commonly tested circulating porphyrins are coproporphyrin, protoporphyrin, and uroporphyrin. Normally protoporphyrin is present in the highest concentration.\nsynonyms :Porphyrin high in blood\n'}


{'id': 'HP_0034607', 'url': 'http://purl.obolibrary.org/obo/HP_0034607', 'lbl': 'Decreased circulating 17-hydroxyprogesterone concentration', 'desc': 'label: Decreased circulating 17-hydroxyprogesterone concentration\ndefinition : Concentration of 17-hydroxyprogesterone in the blood circulation below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034608', 'url': 'http://purl.obolibrary.org/obo/HP_0034608', 'lbl': 'Decreased circulating transcobalamin II concentration', 'desc': 'label: Decreased circulating transcobalamin II concentration\ndefinition : Concentration of transcobalamin II in the blood circulation below the lower limit of normal.\nsynonyms :Transcobalamin II low in blood\n'}


{'id': 'HP_0034609', 'url': 'http://purl.obolibrary.org/obo/HP_0034609', 'lbl': 'Polychromasia', 'desc': 'label: Polychromasia\ndefinition : Increased variation in the color of the erythrocytes (red blood cells), including pale red, normal or dark colors, indicating a highly variable hemoglobin concentration. Typically this indicates the release of immature erythrocytes in states of anemia.\nsynonyms :Polychromasia on peripheral blood smear\n'}


{'id': 'HP_0034610', 'url': 'http://purl.obolibrary.org/obo/HP_0034610', 'lbl': 'Decreased circulating myo-inositol concentration', 'desc': 'label: Decreased circulating myo-inositol concentration\ndefinition : Concentration of myo-inositol in the blood circulation below the lower limit of normal.\nsynonyms :Myoinositol low in blood\n'}


{'id': 'HP_0034611', 'url': 'http://purl.obolibrary.org/obo/HP_0034611', 'lbl': 'Elevated circulating arabitol concentration', 'desc': 'label: Elevated circulating arabitol concentration\ndefinition : Concentration of arabitol in the blood circulation above the upper limit of normal.\nsynonyms :Elevated circulating D-arabinitol concentration\n'}


{'id': 'HP_0034612', 'url': 'http://purl.obolibrary.org/obo/HP_0034612', 'lbl': 'Elevated urine arabitol level', 'desc': 'label: Elevated urine arabitol level\ndefinition : Amount of arabitol in the urine above the upper limit of normal.\nsynonyms :Arabitol high in urine\n'}


{'id': 'HP_0034613', 'url': 'http://purl.obolibrary.org/obo/HP_0034613', 'lbl': 'Elevated urine erythritol level', 'desc': 'label: Elevated urine erythritol level\ndefinition : Amount of erythritol in the urine above the upper limit of normal.\nsynonyms :Erythritol high in urine\n'}


{'id': 'HP_0034614', 'url': 'http://purl.obolibrary.org/obo/HP_0034614', 'lbl': 'Elevated circulating erythritol concentration', 'desc': 'label: Elevated circulating erythritol concentration\ndefinition : Concentration of erythritol in the blood circulation above the upper limit of normal.\nsynonyms :Erythritol high in blood\n'}


{'id': 'HP_0034615', 'url': 'http://purl.obolibrary.org/obo/HP_0034615', 'lbl': 'Reduced circulating matrix metalloproteinase 2 concentration', 'desc': 'label: Reduced circulating matrix metalloproteinase 2 concentration\ndefinition : Concentration of matrix metalloproteinase 2 in the blood circulation below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034616', 'url': 'http://purl.obolibrary.org/obo/HP_0034616', 'lbl': 'Abnormal circulating coenzyme concentration', 'desc': 'label: Abnormal circulating coenzyme concentration\ndefinition : Concentration of a coenzyme (an organic molecule that binds to the active sites of an enzyme to promote the catalysis of a reaction) is above or below the limits of normal.\nsynonyms :\n'}


{'id': 'HP_0034617', 'url': 'http://purl.obolibrary.org/obo/HP_0034617', 'lbl': 'Elevated circulating S-adenosyl methionine concentration', 'desc': 'label: Elevated circulating S-adenosyl methionine concentration\ndefinition : Concentration of S-adenosyl methionine (SAM) in the blood circulation above the upper limit of normal. SAM is a cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.\nsynonyms :S-adenosylmethionine high in blood\n'}


{'id': 'HP_0034618', 'url': 'http://purl.obolibrary.org/obo/HP_0034618', 'lbl': 'Abnormal circulating membrane cofactor protein concentration', 'desc': 'label: Abnormal circulating membrane cofactor protein concentration\ndefinition : Concentration of membrane cofactor protein in the blood circulation outside the limits of normal. Membrane cofactor protein (MCP, CD46) is a cell surface complement regulatory protein which acts as a cofactor for the factor I-mediated cleavage of the activated complement components C3b/C4b.\nsynonyms :\n'}


{'id': 'HP_0034619', 'url': 'http://purl.obolibrary.org/obo/HP_0034619', 'lbl': 'Decreased circulating membrane cofactor protein concentration', 'desc': 'label: Decreased circulating membrane cofactor protein concentration\ndefinition : Concentration of membrane cofactor protein in the blood circulation below the lower limit of normal.\nsynonyms :Decreased circulating CD46 concentration; MCP (membrane cofactor protein) low in blood\n'}


{'id': 'HP_0034620', 'url': 'http://purl.obolibrary.org/obo/HP_0034620', 'lbl': 'Elevated circulating membrane cofactor protein concentration', 'desc': 'label: Elevated circulating membrane cofactor protein concentration\ndefinition : Concentration of membrane cofactor protein in the blood circulation above the upper limit of normal.\nsynonyms :Elevated circulating CD46 concentration\n'}


{'id': 'HP_0034621', 'url': 'http://purl.obolibrary.org/obo/HP_0034621', 'lbl': 'Hepatic xanthomatosis', 'desc': 'label: Hepatic xanthomatosis\ndefinition : Lipid deposits localized within the liver. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.\nsynonyms :Hepatic xanthomas\n'}


{'id': 'HP_0034622', 'url': 'http://purl.obolibrary.org/obo/HP_0034622', 'lbl': 'Adrenal xanthomatosis', 'desc': 'label: Adrenal xanthomatosis\ndefinition : Lipid deposits localized within the adrenal gland. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.\nsynonyms :Adrenal xanthomas\n'}


{'id': 'HP_0034623', 'url': 'http://purl.obolibrary.org/obo/HP_0034623', 'lbl': 'Splenic xanthomatosis', 'desc': 'label: Splenic xanthomatosis\ndefinition : Lipid deposits localized within the spleen. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.\nsynonyms :Spleen xanthomas\n'}


{'id': 'HP_0034624', 'url': 'http://purl.obolibrary.org/obo/HP_0034624', 'lbl': 'Spinal cord xanthomatosis', 'desc': 'label: Spinal cord xanthomatosis\ndefinition : Lipid deposits localized within the spinal cord. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.\nsynonyms :Spinal cord xanthomas\n'}


{'id': 'HP_0034625', 'url': 'http://purl.obolibrary.org/obo/HP_0034625', 'lbl': 'Brain xanthomatosis', 'desc': 'label: Brain xanthomatosis\ndefinition : Lipid deposits localized within the brain. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.\nsynonyms :Brain xanthomas; Brain xanthomata\n'}


{'id': 'HP_0034626', 'url': 'http://purl.obolibrary.org/obo/HP_0034626', 'lbl': 'Pulmonary xanthomatosis', 'desc': 'label: Pulmonary xanthomatosis\ndefinition : Lipid deposits localized within the lung. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.\nsynonyms :Lung xanthoma; Pulmonary xanthoma\n'}


{'id': 'HP_0034627', 'url': 'http://purl.obolibrary.org/obo/HP_0034627', 'lbl': 'Bone marrow xanthomatosis', 'desc': 'label: Bone marrow xanthomatosis\ndefinition : Lipid deposits localized within the bone marrow. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.\nsynonyms :Bone marrow xanthomas\n'}


{'id': 'HP_0034628', 'url': 'http://purl.obolibrary.org/obo/HP_0034628', 'lbl': 'Lymph node xanthomatosis', 'desc': 'label: Lymph node xanthomatosis\ndefinition : Lipid deposits localized within one or more lymph nodes. Xanthomas are benign but are often an important visible sign of systemic conditions such as familial hypercholesterolemia.\nsynonyms :Lymph node xanthomas\n'}


{'id': 'HP_0034629', 'url': 'http://purl.obolibrary.org/obo/HP_0034629', 'lbl': 'Xanthoma of bone', 'desc': 'label: Xanthoma of bone\ndefinition : Xanthoma of bone is an exceedingly rare benign primary bone tumor histologically characterized by mononuclear macrophage-like cells, abundant foam cells, and multinucleated giant cells.\nsynonyms :Bone xanthoma\n'}


{'id': 'HP_0034630', 'url': 'http://purl.obolibrary.org/obo/HP_0034630', 'lbl': 'Ameliorated by folinic acid', 'desc': 'label: Ameliorated by folinic acid\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with folinic acid.\nsynonyms :Ameliorated by leucovorin\n'}


{'id': 'HP_0034631', 'url': 'http://purl.obolibrary.org/obo/HP_0034631', 'lbl': 'Triggered by succinylcholine anesthetic', 'desc': 'label: Triggered by succinylcholine anesthetic\ndefinition : Applies to a sign or symptom that is provoked or brought about by exposure to a succinylcholine anesthetic such as suxamethonium.\nsynonyms :Triggered by suxamethonium\n'}


{'id': 'HP_0034632', 'url': 'http://purl.obolibrary.org/obo/HP_0034632', 'lbl': 'Exogenous androgen exposure', 'desc': 'label: Exogenous androgen exposure\ndefinition : History of having been treated with an exogenous androgen medication.\nsynonyms :Androgen exposure, exogenous\n'}


{'id': 'HP_0034633', 'url': 'http://purl.obolibrary.org/obo/HP_0034633', 'lbl': 'Reduced muscle enolase activity', 'desc': 'label: Reduced muscle enolase activity\ndefinition : Diminished activity of the enzyme enolase in muscle tissue. The enzyme enolase catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate. In adult human muscle, over 90% of enolase activity is accounted for by the beta-enolase subunit, the protein product of the ENO3 gene.\nsynonyms :Muscle biopsy: beta-enolase activity low\n'}


{'id': 'HP_0034634', 'url': 'http://purl.obolibrary.org/obo/HP_0034634', 'lbl': 'Dopamine antagonist exposure', 'desc': 'label: Dopamine antagonist exposure\ndefinition : History of having been treated with a dopamine antagonist including metaclopramide, phenothiazine; haloperidol, chlorpromazine, promethazine, prochlorperazine, ziprasidone, and quetiapine.\nsynonyms :Dopamine antagonist treatment history\n'}


{'id': 'HP_0034635', 'url': 'http://purl.obolibrary.org/obo/HP_0034635', 'lbl': 'Muscle fiber granulofilamentous inclusion bodies', 'desc': 'label: Muscle fiber granulofilamentous inclusion bodies\ndefinition : The presence of inclusion bodies within the cytoplasm of muscle cells that contain a mxiture of granules and filaments.\nsynonyms :\n'}


{'id': 'HP_0034636', 'url': 'http://purl.obolibrary.org/obo/HP_0034636', 'lbl': 'Bone marrow myeloid vacuolization', 'desc': 'label: Bone marrow myeloid vacuolization\ndefinition : Formation of vacuoles (a space within a cell that is empty of cytoplasm, lined with a membrane, and filled with fluid) in the cytoplasm of myeloid precursors in the bone marrow.\nsynonyms :Bone marrow: myeloid vacuolization; Vacuolization of bone marrow myeloid precursors\n'}


{'id': 'HP_0034637', 'url': 'http://purl.obolibrary.org/obo/HP_0034637', 'lbl': 'Pulmonary cylindroma', 'desc': 'label: Pulmonary cylindroma\ndefinition : A cylindroma located in the lung. Cylindromas are well-circumscribed, smooth, pale pink nodular tumors, often with arborizing vessels visible. The tumors are slow growing and vary in size from a few millimeters to over 5 mm.\nsynonyms :\n'}


{'id': 'HP_0034638', 'url': 'http://purl.obolibrary.org/obo/HP_0034638', 'lbl': 'Colonic fibrinopurulent exudate', 'desc': 'label: Colonic fibrinopurulent exudate\ndefinition : Fluid visible on the colonic surface containing fibrin, inflammatory cells, and cellular debris.\nsynonyms :\n'}


{'id': 'HP_0034639', 'url': 'http://purl.obolibrary.org/obo/HP_0034639', 'lbl': 'Bloodstream microfilaria', 'desc': 'label: Bloodstream microfilaria\ndefinition : Presence of filaria in the blood stream. Filariasis is a common cause of elephantiasis in Coastal Districts of India. The initial manifestations are repeated episodes of fever with chills and rigor, lymphadenopathy which gradually progress to elephantiasis. In India filarial infestation is commonly caused by W. bancrofti and Brugia malayi, the former responsible for almost 98 percent of all cases.\nsynonyms :\n'}


{'id': 'HP_0034640', 'url': 'http://purl.obolibrary.org/obo/HP_0034640', 'lbl': 'Skin infectious agent', 'desc': 'label: Skin infectious agent\ndefinition : The presence of an infectious agent in the skin.\nsynonyms :\n'}


{'id': 'HP_0034641', 'url': 'http://purl.obolibrary.org/obo/HP_0034641', 'lbl': 'Dermal microfilaria', 'desc': 'label: Dermal microfilaria\ndefinition : Presence of filariae in the skin.\nsynonyms :Dermal microfilariae\n'}


{'id': 'HP_0034642', 'url': 'http://purl.obolibrary.org/obo/HP_0034642', 'lbl': 'Dermal papillary IgA deposition', 'desc': 'label: Dermal papillary IgA deposition\ndefinition : Accumulation of immunoglobulin A (IgA) surrounding dermal papillae, which are specialized cells that support the hair follicle.\nsynonyms :Granular IgA deposits at the dermal papillae\n'}


{'id': 'HP_0034643', 'url': 'http://purl.obolibrary.org/obo/HP_0034643', 'lbl': 'Dermal immune complex deposition', 'desc': 'label: Dermal immune complex deposition\ndefinition : Accumulation of antigen-bound antibody in the skin.\nsynonyms :\n'}


{'id': 'HP_0034644', 'url': 'http://purl.obolibrary.org/obo/HP_0034644', 'lbl': 'Abnormal liver metabolite concentration', 'desc': 'label: Abnormal liver metabolite concentration\ndefinition : The concentration of a metabolite in the liver is above or below the limits of normal.\nsynonyms :\n'}


{'id': 'HP_0034645', 'url': 'http://purl.obolibrary.org/obo/HP_0034645', 'lbl': 'Hepatic polyglucosan accumulation', 'desc': 'label: Hepatic polyglucosan accumulation\ndefinition : Intracellular accumulation of polyglucosan bodies-containing amylopectinlike polysaccharide-in the liver.\nsynonyms :Accumulation of polyglucosan bodies in the liver\n'}


{'id': 'HP_0034646', 'url': 'http://purl.obolibrary.org/obo/HP_0034646', 'lbl': 'Urinary bladder neurofibroma', 'desc': 'label: Urinary bladder neurofibroma\ndefinition : A neurofibroma (benign peripheral nerve sheath tumor) located in the urinary bladder.\nsynonyms :Bladder neurofibroma\n'}


{'id': 'HP_0034647', 'url': 'http://purl.obolibrary.org/obo/HP_0034647', 'lbl': 'Synovial granuloma', 'desc': 'label: Synovial granuloma\ndefinition : An aggregation of macrophages (forming in response to chronic inflammation) localized in the lining of a joint (synovium).\nsynonyms :\n'}


{'id': 'HP_0034648', 'url': 'http://purl.obolibrary.org/obo/HP_0034648', 'lbl': 'Elevated urine fumaric acid level', 'desc': 'label: Elevated urine fumaric acid level\ndefinition : Amount of fumaric acid in the urine above normal limits.\nsynonyms :Elevated urine fumarate level\n'}


{'id': 'HP_0034649', 'url': 'http://purl.obolibrary.org/obo/HP_0034649', 'lbl': 'Elevated urine N-acetylaspartic acid level', 'desc': 'label: Elevated urine N-acetylaspartic acid level\ndefinition : Amoutn of N-acetylaspartate high in the urine above upper limit of normal.\nsynonyms :N-acetylaspartate high in urine\n'}


{'id': 'HP_0034650', 'url': 'http://purl.obolibrary.org/obo/HP_0034650', 'lbl': 'Elevated urine suberylglycine level', 'desc': 'label: Elevated urine suberylglycine level\ndefinition : Level of suberylglycine in urine above upper limit of normal.\nsynonyms :Suberylglycine high in urine\n'}


{'id': 'HP_0034651', 'url': 'http://purl.obolibrary.org/obo/HP_0034651', 'lbl': 'Elevated urine phenylpropionylglycine level', 'desc': 'label: Elevated urine phenylpropionylglycine level\ndefinition : Level of phenylpropionylglycine in urine above upper limit of normal.\nsynonyms :Phenylpropionylglycine present in urine\n'}


{'id': 'HP_0034652', 'url': 'http://purl.obolibrary.org/obo/HP_0034652', 'lbl': 'Elevated urine octenedioic acid level', 'desc': 'label: Elevated urine octenedioic acid level\ndefinition : Amount of octenedioic acid in the urine above the upper limit of normal.\nsynonyms :Octenedioic acid high in urine\n'}


{'id': 'HP_0034653', 'url': 'http://purl.obolibrary.org/obo/HP_0034653', 'lbl': 'Monocarboxylic aciduria', 'desc': 'label: Monocarboxylic aciduria\ndefinition : Level of a monocarboxylic acid in the urine above the upper limit of normal. A monocarboxylic acid is an oxoacid containing one carboxy group.\nsynonyms :\n'}


{'id': 'HP_0034654', 'url': 'http://purl.obolibrary.org/obo/HP_0034654', 'lbl': 'Elevated urine octanoic acid level', 'desc': 'label: Elevated urine octanoic acid level\ndefinition : Amount of octanoic acid in the urine above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034655', 'url': 'http://purl.obolibrary.org/obo/HP_0034655', 'lbl': 'Elevated urine glutaconic acid level', 'desc': 'label: Elevated urine glutaconic acid level\ndefinition : Amount of glutaconic acid in the urine above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034656', 'url': 'http://purl.obolibrary.org/obo/HP_0034656', 'lbl': 'Elevated urine 3-hydroxyglutaric level', 'desc': 'label: Elevated urine 3-hydroxyglutaric level\ndefinition : Amount of 3-hydroxyglutaric acid in urine above the upper limit of normal.\nsynonyms :3-hydroxyglutaric acid high in urine\n'}


{'id': 'HP_0034657', 'url': 'http://purl.obolibrary.org/obo/HP_0034657', 'lbl': 'Elevated urine malonic acid level', 'desc': 'label: Elevated urine malonic acid level\ndefinition : Amount of malonic acid in urine above upper limit of normal.\nsynonyms :Malonic acid present in urine\n'}


{'id': 'HP_0034658', 'url': 'http://purl.obolibrary.org/obo/HP_0034658', 'lbl': 'Elevated urine propionylglycine level', 'desc': 'label: Elevated urine propionylglycine level\ndefinition : Amount of propionylglycine in the urine above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034659', 'url': 'http://purl.obolibrary.org/obo/HP_0034659', 'lbl': 'Elevated urine tiglylglycine level', 'desc': 'label: Elevated urine tiglylglycine level\ndefinition : Amount of tiglylglycine in the urine above upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034660', 'url': 'http://purl.obolibrary.org/obo/HP_0034660', 'lbl': 'Elevated urine 2-methylacetoacetic acid level', 'desc': 'label: Elevated urine 2-methylacetoacetic acid level\ndefinition : Amount of 2-methylacetoacetic acid in the urine above upper limit of normal.\nsynonyms :2-methylacetoacetic acid present in urine\n'}


{'id': 'HP_0034661', 'url': 'http://purl.obolibrary.org/obo/HP_0034661', 'lbl': 'Elevated urine 3-hydroxypropionic acid level', 'desc': 'label: Elevated urine 3-hydroxypropionic acid level\ndefinition : Amount of 3-hydroxypropionic acid in the urine above the upper limit of normal.\nsynonyms :3-hydroxypropionic acid high in urine\n'}


{'id': 'HP_0034662', 'url': 'http://purl.obolibrary.org/obo/HP_0034662', 'lbl': 'Elevated urine 2-methylcitric acid level', 'desc': 'label: Elevated urine 2-methylcitric acid level\ndefinition : Amount of 2-methylcitric acid in the urine above the upper limit of normal.\nsynonyms :2-methylcitric acid high in urine; Elevated urine 2-methylcitrate level\n'}


{'id': 'HP_0034663', 'url': 'http://purl.obolibrary.org/obo/HP_0034663', 'lbl': 'Elevated urine 4-hydroxyisovaleric acid level', 'desc': 'label: Elevated urine 4-hydroxyisovaleric acid level\ndefinition : Amount of 4-hydroxyisovaleric acid in urine above upper limit of normal.\nsynonyms :4-hydroxyisovaleric acid present in urine\n'}


{'id': 'HP_0034664', 'url': 'http://purl.obolibrary.org/obo/HP_0034664', 'lbl': 'Elevated urine 2-hydroxy-3-methylvaleric acid level', 'desc': 'label: Elevated urine 2-hydroxy-3-methylvaleric acid level\ndefinition : Amount of 2-hydroxy-3-methylvaleric acid in the urine above the upper limit of normal. 2-Hydroxy-3-methylpentanoic acid or 2-hydroxy-3-methylvaleric acid (HMVA) is an organic acid generated by L-isoleucine metabolism.\nsynonyms :2-hydroxy-3-methylvaleric acid high in urine\n'}


{'id': 'HP_0034665', 'url': 'http://purl.obolibrary.org/obo/HP_0034665', 'lbl': 'Shoulder contracture', 'desc': 'label: Shoulder contracture\ndefinition : Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the shoulder joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.\nsynonyms :\n'}


{'id': 'HP_0034666', 'url': 'http://purl.obolibrary.org/obo/HP_0034666', 'lbl': 'Shoulder extension contracture', 'desc': "label: Shoulder extension contracture\ndefinition : Lack of the full expected passive range of flexion of the shoulder joint (Shoulder flexion puts the arms from a resting position at one's sides to straight above the head; thus, with shoulder extension contracture it is not possible to raise the arms above the head fully).\nsynonyms :\n"}


{'id': 'HP_0034667', 'url': 'http://purl.obolibrary.org/obo/HP_0034667', 'lbl': 'Thumb extension contracture', 'desc': 'label: Thumb extension contracture\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034668', 'url': 'http://purl.obolibrary.org/obo/HP_0034668', 'lbl': 'Tongue myxoma', 'desc': 'label: Tongue myxoma\ndefinition : A myxoma (benign soft tissue neoplasm characterized by the presence of spindle and stellate cells, lobulated growth pattern, and myxoid stroma formation) localized in the tongue.\nsynonyms :\n'}


{'id': 'HP_0034669', 'url': 'http://purl.obolibrary.org/obo/HP_0034669', 'lbl': 'Abnormal knee morphology', 'desc': 'label: Abnormal knee morphology\ndefinition : A structural abnormality of the knee joint or surrounding structures.\nsynonyms :\n'}


{'id': 'HP_0034670', 'url': 'http://purl.obolibrary.org/obo/HP_0034670', 'lbl': 'Abnormal knee physiology', 'desc': 'label: Abnormal knee physiology\ndefinition : A functional anomaly of the knee joint.\nsynonyms :\n'}


{'id': 'HP_0034671', 'url': 'http://purl.obolibrary.org/obo/HP_0034671', 'lbl': 'Knee contracture', 'desc': 'label: Knee contracture\ndefinition : Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of the knee joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.\nsynonyms :Contracture of knee; Contracture of the knees; Knee contractures\n'}


{'id': 'HP_0034672', 'url': 'http://purl.obolibrary.org/obo/HP_0034672', 'lbl': 'Knee extension contracture', 'desc': 'label: Knee extension contracture\ndefinition : A type of knee joint contracture in which the knee lacks full expected flexion, such that the upper and lower leg cannot be brought together.\nsynonyms :\n'}


{'id': 'HP_0034673', 'url': 'http://purl.obolibrary.org/obo/HP_0034673', 'lbl': 'Abnormal ankle morphology', 'desc': 'label: Abnormal ankle morphology\ndefinition : A structural anomaly of the ankle.\nsynonyms :\n'}


{'id': 'HP_0034674', 'url': 'http://purl.obolibrary.org/obo/HP_0034674', 'lbl': 'Abnormal ankle physiology', 'desc': 'label: Abnormal ankle physiology\ndefinition : A functional anomaly of the ankle.\nsynonyms :\n'}


{'id': 'HP_0034675', 'url': 'http://purl.obolibrary.org/obo/HP_0034675', 'lbl': 'Toe joint contracture', 'desc': 'label: Toe joint contracture\ndefinition : Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of a toe joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.\nsynonyms :\n'}


{'id': 'HP_0034676', 'url': 'http://purl.obolibrary.org/obo/HP_0034676', 'lbl': 'Extension contracture of toe', 'desc': 'label: Extension contracture of toe\ndefinition : A type of toe joint contracture in which the joint lacks full expected flexion, so that the two bony segments on either side of their connecting joint cannot be brought together.\nsynonyms :\n'}


{'id': 'HP_0034677', 'url': 'http://purl.obolibrary.org/obo/HP_0034677', 'lbl': 'Ankle contracture', 'desc': 'label: Ankle contracture\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034678', 'url': 'http://purl.obolibrary.org/obo/HP_0034678', 'lbl': 'Forefoot pronation contracture', 'desc': 'label: Forefoot pronation contracture\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034679', 'url': 'http://purl.obolibrary.org/obo/HP_0034679', 'lbl': 'Forefoot supination contracture', 'desc': 'label: Forefoot supination contracture\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034680', 'url': 'http://purl.obolibrary.org/obo/HP_0034680', 'lbl': 'Forefoot adduction contracture', 'desc': 'label: Forefoot adduction contracture\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034681', 'url': 'http://purl.obolibrary.org/obo/HP_0034681', 'lbl': 'Finger joint contracture', 'desc': 'label: Finger joint contracture\ndefinition : Lack of full passive range of motion (restrictions in flexion, extension, or other movements) of a finger joint resulting from structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules and/or skin.\nsynonyms :\n'}


{'id': 'HP_0034682', 'url': 'http://purl.obolibrary.org/obo/HP_0034682', 'lbl': 'Extension contracture of finger', 'desc': 'label: Extension contracture of finger\ndefinition : A type of finger joint contracture in which the joint lacks full expected flexion, so that the two bony segments on either side of their connecting joint cannot be brought together.\nsynonyms :\n'}


{'id': 'HP_0034683', 'url': 'http://purl.obolibrary.org/obo/HP_0034683', 'lbl': 'Reduced muscle telethonin level', 'desc': 'label: Reduced muscle telethonin level\ndefinition : Amount of telethonin protein expression in muscle tissue below lower limit of normal. Telethonin is a 19-kDa sarcomeric protein, localized to the Z-disc of skeletal and cardiac muscles.\nsynonyms :Muscle biopsy: telethonin low or absent\n'}


{'id': 'HP_0034684', 'url': 'http://purl.obolibrary.org/obo/HP_0034684', 'lbl': 'Abnormal enzyme concentration or activity', 'desc': 'label: Abnormal enzyme concentration or activity\ndefinition : Concentration or activity of an enzyme is above or below the limits of normal.\nsynonyms :\n'}


{'id': 'HP_0034685', 'url': 'http://purl.obolibrary.org/obo/HP_0034685', 'lbl': 'Abnormal liver enzyme activity or concentration', 'desc': 'label: Abnormal liver enzyme activity or concentration\ndefinition : Concentration or activity of an enzyme is above or below the limits of normal in liver tissue.\nsynonyms :Abnormal hepatic enzyme activity or concentration\n'}


{'id': 'HP_0034686', 'url': 'http://purl.obolibrary.org/obo/HP_0034686', 'lbl': 'Reduced hepatic urocanase activity', 'desc': 'label: Reduced hepatic urocanase activity\ndefinition : Activity of urocanase in the liver below the lower limit of normal.\nsynonyms :Liver biopsy: urocanase activity low\n'}


{'id': 'HP_0034687', 'url': 'http://purl.obolibrary.org/obo/HP_0034687', 'lbl': 'Impaired cerebroside sulfate hydrolysis', 'desc': 'label: Impaired cerebroside sulfate hydrolysis\ndefinition : Reduced hydrolysis (splitting of a bond and the addition of the hydrogen anion of water) of the sulfuric ester linkage in the molecule of cerebroside sulfate, possibly leading to accumuation of cerebroside sulfate.\nsynonyms :\n'}


{'id': 'HP_0034688', 'url': 'http://purl.obolibrary.org/obo/HP_0034688', 'lbl': 'Reduced peroxisomal glutaryl-CoA oxidase activity', 'desc': 'label: Reduced peroxisomal glutaryl-CoA oxidase activity\ndefinition : Diminished enzyme activity of peroxisomal glutaryl-CoA oxidase, an enzyme that metabolizes glutaryl-CoA (a metabolite of L-lysine, L-hydroxy-lysine and L-tryptophan) by dehydrogenation to glutaconyl-CoA directly followed by decarboxylation of this to crotonyl-CoA.\nsynonyms :\n'}


{'id': 'HP_0034689', 'url': 'http://purl.obolibrary.org/obo/HP_0034689', 'lbl': 'Reduced sterol 27-hydroxylase activity', 'desc': 'label: Reduced sterol 27-hydroxylase activity\ndefinition : Diminished activity of the enzyme sterol 27-hydroxylase, which participates in the degradation of cholesterol to bile acid. Sterol 27-hydroxylase catalyzes the first step in the normal oxidation of the steroid side chain, converting cholesterol, as well as different 7a-hydroxylated cholesterol metabolites, to 27-oxygenated steroids.\nsynonyms :\n'}


{'id': 'HP_0034690', 'url': 'http://purl.obolibrary.org/obo/HP_0034690', 'lbl': 'Reduced short-chain acyl-CoA dehydrogenase activity', 'desc': 'label: Reduced short-chain acyl-CoA dehydrogenase activity\ndefinition : Diminished activbity of the enzyme Short-chain acyl-CoA dehydrogenase (SCAD), a key enzyme of fatty acid beta-oxidation that catalyses the first step in mitochondrial beta-oxidation of fatty acids.\nsynonyms :\n'}


{'id': 'HP_0034691', 'url': 'http://purl.obolibrary.org/obo/HP_0034691', 'lbl': 'Reduced 3-phosphoglycerate dehydrogenase activity', 'desc': 'label: Reduced 3-phosphoglycerate dehydrogenase activity\ndefinition : Diminished activity of the enzyme 3-phosphoglycerate dehydrogenase (PGDH), which catalyzes the first step in the pathway by converting D-3-phosphoglycerate (PGA), an intermediate in glycolysis, to phosphohydroxypyruvate concomitant with the reduction of NAD+.\nsynonyms :\n'}


{'id': 'HP_0034692', 'url': 'http://purl.obolibrary.org/obo/HP_0034692', 'lbl': 'Elongated mitochondria', 'desc': 'label: Elongated mitochondria\ndefinition : Increase in length of mitochondria.\nsynonyms :\n'}


{'id': 'HP_0034693', 'url': 'http://purl.obolibrary.org/obo/HP_0034693', 'lbl': 'Reduced hepatic methionine adenosyltransferase activity', 'desc': 'label: Reduced hepatic methionine adenosyltransferase activity\ndefinition : Activity of methionine adenosyltransferase in the liver below the lower limit of normal. Note that there are multiple methionine adenosyltransferase isoezymes.\nsynonyms :\n'}


{'id': 'HP_0034694', 'url': 'http://purl.obolibrary.org/obo/HP_0034694', 'lbl': 'Substantia nigra dopaminergic neuron loss', 'desc': 'label: Substantia nigra dopaminergic neuron loss\ndefinition : Degeneration and loss of neruons in the substantia nigra of the brain.\nsynonyms :\n'}


{'id': 'HP_0034696', 'url': 'http://purl.obolibrary.org/obo/HP_0034696', 'lbl': 'Intramuscular lipoma', 'desc': 'label: Intramuscular lipoma\ndefinition : A lipoma that is located within a muscle.\nsynonyms :\n'}


{'id': 'HP_0034697', 'url': 'http://purl.obolibrary.org/obo/HP_0034697', 'lbl': 'Cutaneous telangiectasia', 'desc': 'label: Cutaneous telangiectasia\ndefinition : Dilated blood vessels on the skin.\nsynonyms :\n'}


{'id': 'HP_0034698', 'url': 'http://purl.obolibrary.org/obo/HP_0034698', 'lbl': 'Abnormal aromatase activity', 'desc': 'label: Abnormal aromatase activity\ndefinition : Aromatase activity outside of the normal range.\nsynonyms :\n'}


{'id': 'HP_0034699', 'url': 'http://purl.obolibrary.org/obo/HP_0034699', 'lbl': 'Elevated aromatase activity', 'desc': 'label: Elevated aromatase activity\ndefinition : Enzyme activity of aromatase above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034700', 'url': 'http://purl.obolibrary.org/obo/HP_0034700', 'lbl': 'Reduced aromatase activity', 'desc': 'label: Reduced aromatase activity\ndefinition : Enzyme activity of aromatase below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034701', 'url': 'http://purl.obolibrary.org/obo/HP_0034701', 'lbl': 'Corneal amyloidosis', 'desc': 'label: Corneal amyloidosis\ndefinition : A form of amyloidosis that is located in the cornea.\nsynonyms :\n'}


{'id': 'HP_0034702', 'url': 'http://purl.obolibrary.org/obo/HP_0034702', 'lbl': 'Abnormal keratinocyte morphology', 'desc': 'label: Abnormal keratinocyte morphology\ndefinition : Any structural anomaly of the keratinocyte. The keratinocyte is the major cell type of the epidermis and is responsible for generating the protective barrier.\nsynonyms :\n'}


{'id': 'HP_0034703', 'url': 'http://purl.obolibrary.org/obo/HP_0034703', 'lbl': 'Keratinocyte vacuolization', 'desc': 'label: Keratinocyte vacuolization\ndefinition : Increased number of vacuoles (membrane-bound organelles that areempty of cytoplasm, lined with a membrane, and filled with fluid) in keratinocytes.\nsynonyms :Keratinocyte vacuolation; Vacuolated keratinocytes\n'}


{'id': 'HP_0034704', 'url': 'http://purl.obolibrary.org/obo/HP_0034704', 'lbl': 'Parotid gland adenocarcinoma', 'desc': 'label: Parotid gland adenocarcinoma\ndefinition : An adenocarcinoma that arises from the parotid gland.\nsynonyms :\n'}


{'id': 'HP_0034705', 'url': 'http://purl.obolibrary.org/obo/HP_0034705', 'lbl': 'Pulmonary vasculitis', 'desc': 'label: Pulmonary vasculitis\ndefinition : Cellular inflammation, vessel destruction, and tissue necrosis of the blood vessels of the lung.\nsynonyms :Lung biopsy: vasculitis\n'}


{'id': 'HP_0034706', 'url': 'http://purl.obolibrary.org/obo/HP_0034706', 'lbl': 'Reduced hepatic D-glycerate kinase activity', 'desc': 'label: Reduced hepatic D-glycerate kinase activity\ndefinition : Activity of D-glycerate kinase in the liver below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034707', 'url': 'http://purl.obolibrary.org/obo/HP_0034707', 'lbl': 'Lymph-node hemophagocytosis', 'desc': 'label: Lymph-node hemophagocytosis\ndefinition : Phagocytosis of erythrocytes, lymphocytes or other hematopoietic precursors by histiocytes or macrophages either in a lymph node.\nsynonyms :\n'}


{'id': 'HP_0034708', 'url': 'http://purl.obolibrary.org/obo/HP_0034708', 'lbl': 'Superior pubic ramus hypoplasia', 'desc': 'label: Superior pubic ramus hypoplasia\ndefinition : Underdevelopment of the upper branch of the pubis bone (inferior pubic ramus).\nsynonyms :\n'}


{'id': 'HP_0034709', 'url': 'http://purl.obolibrary.org/obo/HP_0034709', 'lbl': 'Uterine adenofibroma', 'desc': 'label: Uterine adenofibroma\ndefinition : A rare benign mullerian mixed tumor of the uterus composed of benign epithelial and mesenchymal components.\nsynonyms :\n'}


{'id': 'HP_0034710', 'url': 'http://purl.obolibrary.org/obo/HP_0034710', 'lbl': 'Pulmonary hamartoma', 'desc': 'label: Pulmonary hamartoma\ndefinition : A benign malformation of the lung that includes an abnormal mixture of tissue components such as cartilage, epithelium, fat, or muscle which are common to the lung but without preservation of the organ architecture.\nsynonyms :\n'}


{'id': 'HP_0034711', 'url': 'http://purl.obolibrary.org/obo/HP_0034711', 'lbl': 'Peripheral axonal distension', 'desc': 'label: Peripheral axonal distension\ndefinition : An abnormal histological finding characterized by an increase in the cross-section area of peripheral nerve axons (up to 20-25 micrometers in diameter).\nsynonyms :\n'}


{'id': 'HP_0034712', 'url': 'http://purl.obolibrary.org/obo/HP_0034712', 'lbl': 'Decreased alpha-mannosidase activity', 'desc': 'label: Decreased alpha-mannosidase activity\ndefinition : Activity of the enzyme alpha-mannosidase below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034713', 'url': 'http://purl.obolibrary.org/obo/HP_0034713', 'lbl': 'Abnormal hepatocyte morphology', 'desc': 'label: Abnormal hepatocyte morphology\ndefinition : A structural anomaly of the hepatocyte, which is the main cell type that makes up the liver perncyhma. Hepatocytes are usually binucleated and appear as sheets in the liver tissue.\nsynonyms :\n'}


{'id': 'HP_0034714', 'url': 'http://purl.obolibrary.org/obo/HP_0034714', 'lbl': 'Hepatic melanin-like lysosomal pigmentation', 'desc': 'label: Hepatic melanin-like lysosomal pigmentation\ndefinition : Accumulation of dark, coarsely granular pigment localized in lysosomes of centrilobular hepatocytes.\nsynonyms :\n'}


{'id': 'HP_0034715', 'url': 'http://purl.obolibrary.org/obo/HP_0034715', 'lbl': 'Reduced uroporphyrinogen decarboxylase activity', 'desc': 'label: Reduced uroporphyrinogen decarboxylase activity\ndefinition : Activity of the enzyme uroporphyrinogen decarboxylase (UROD; EC 4.1.1.37) below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034716', 'url': 'http://purl.obolibrary.org/obo/HP_0034716', 'lbl': 'Reduced heme oxygenase activity', 'desc': 'label: Reduced heme oxygenase activity\ndefinition : Activity of the enzyme heme oxygenase below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034717', 'url': 'http://purl.obolibrary.org/obo/HP_0034717', 'lbl': 'Cerebral cortex swollen achromatic neurons', 'desc': 'label: Cerebral cortex swollen achromatic neurons\ndefinition : The presence of enlarged and swollen neurons that lack Nissl bodies (the rough endoplasmic reticulum-achromasia refers to neurons that lack Nissl bodies) in the cortex of the brain.\nsynonyms :Cerebral cortex Pick cells\n'}


{'id': 'HP_0034718', 'url': 'http://purl.obolibrary.org/obo/HP_0034718', 'lbl': 'Vacuolated hepatocytes', 'desc': 'label: Vacuolated hepatocytes\ndefinition : Presence of vacuoles (membrane-bound organelles that areempty of cytoplasm, lined with a membrane, and filled with fluid) in hepatocytes, which normally rarely contain vacuoles.\nsynonyms :Hepatocyte vacuolization\n'}


{'id': 'HP_0034719', 'url': 'http://purl.obolibrary.org/obo/HP_0034719', 'lbl': 'Lack of oocyte pronucleus formation', 'desc': 'label: Lack of oocyte pronucleus formation\ndefinition : An abnormality of oocyte maturation characterized by the inability of oocytes to form pronuclei after in vitro fertilization procedures. Oocytes normally show two pronuclei 17 to 20 hours after in vitro insemination.\nsynonyms :\n'}


{'id': 'HP_0034720', 'url': 'http://purl.obolibrary.org/obo/HP_0034720', 'lbl': 'Self-healing squamous epithelioma', 'desc': 'label: Self-healing squamous epithelioma\ndefinition : A type of skin tumor that initially presents as a reddish macule and subsequently becomes papular, enlarged, ulcerated and ultimately heals leaving pitted scars.\nsynonyms :\n'}


{'id': 'HP_0034721', 'url': 'http://purl.obolibrary.org/obo/HP_0034721', 'lbl': 'Elevated circulating pristanic acid concentration', 'desc': 'label: Elevated circulating pristanic acid concentration\ndefinition : Concentration of pristanic acid in the blood circulation above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034722', 'url': 'http://purl.obolibrary.org/obo/HP_0034722', 'lbl': 'Sarcoplasmic bodies', 'desc': 'label: Sarcoplasmic bodies\ndefinition : Rounded or oval structures that appeared brown on hematoxylin and eosin and red on the modified Gomori trichrome stain.\nsynonyms :\n'}


{'id': 'HP_0034723', 'url': 'http://purl.obolibrary.org/obo/HP_0034723', 'lbl': 'Elevated CSF hydroxyproline concentration', 'desc': 'label: Elevated CSF hydroxyproline concentration\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0034724', 'url': 'http://purl.obolibrary.org/obo/HP_0034724', 'lbl': 'Reduced CSF cystine concentration', 'desc': 'label: Reduced CSF cystine concentration\ndefinition : Concentration of cystine in the cerebrospinal fluid below the lower limit of normal. Cystine is sulfur-containing amino acid obtained by the oxidation of two cysteine molecules which are then linked via a disulfide bond.\nsynonyms :Cystine low in CSF\n'}


{'id': 'HP_0034725', 'url': 'http://purl.obolibrary.org/obo/HP_0034725', 'lbl': 'Abnormal beta-mannosidase activity', 'desc': 'label: Abnormal beta-mannosidase activity\ndefinition : Activity of the enzyme beta-mannosidase outside normal limits. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides.\nsynonyms :\n'}


{'id': 'HP_0034726', 'url': 'http://purl.obolibrary.org/obo/HP_0034726', 'lbl': 'Elevated beta-mannosidase activity', 'desc': 'label: Elevated beta-mannosidase activity\ndefinition : Activity of the enzyme beta-mannosidase above the upper limit of normal. Beta-mannosidase is a lysosomal enzyme that catabolizes oligosaccharides.\nsynonyms :Beta-mannosidase high in blood\n'}


{'id': 'HP_0034727', 'url': 'http://purl.obolibrary.org/obo/HP_0034727', 'lbl': 'Reduced alpha-L-fucosidase activity', 'desc': 'label: Reduced alpha-L-fucosidase activity\ndefinition : Activity of the enzyme alpha-L-fucosidase below the lower limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034728', 'url': 'http://purl.obolibrary.org/obo/HP_0034728', 'lbl': 'Abnormal alpha-L-fucosidase activity', 'desc': 'label: Abnormal alpha-L-fucosidase activity\ndefinition : Activity of the enzyme alpha-L-fucosidase outside the limits of normal.\nsynonyms :\n'}


{'id': 'HP_0034729', 'url': 'http://purl.obolibrary.org/obo/HP_0034729', 'lbl': 'Elevated alpha-L-fucosidase activity', 'desc': 'label: Elevated alpha-L-fucosidase activity\ndefinition : Activity of the enzyme alpha-L-fucosidase above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034730', 'url': 'http://purl.obolibrary.org/obo/HP_0034730', 'lbl': 'Elevated circulating S-adenosyl-L-homocysteine concentration', 'desc': 'label: Elevated circulating S-adenosyl-L-homocysteine concentration\ndefinition : Increased concentration of S-adenosyl-L-homocysteine in the blood circulation.\nsynonyms :Elevated AdoHcy concentration\n'}


{'id': 'HP_0034731', 'url': 'http://purl.obolibrary.org/obo/HP_0034731', 'lbl': 'Elevated circulating S-adenosyl-L-methionine concentration', 'desc': 'label: Elevated circulating S-adenosyl-L-methionine concentration\ndefinition : Concentration S-adenosyl-L-methionine in the blood circulation above the upper limit of normal.\nsynonyms :High blood AdoMet\n'}


{'id': 'HP_0034732', 'url': 'http://purl.obolibrary.org/obo/HP_0034732', 'lbl': 'Exercise-triggered malignant hyperthermia', 'desc': 'label: Exercise-triggered malignant hyperthermia\ndefinition : Malignant hyperthermia that is characterized by exercise-induced life-threatening hyperthermia with a body temperature over 40°C and signs of encephalopathy ranging from confusion to convulsions or coma. Incidence increases with rising ambient temperature and relative humidity. Manifestations may include rhabdomyolysis (presenting with myalgia, muscle weakness, and myoglobinuria), tachycardia, and in severe cases multiorgan failure.\nsynonyms :Exertional heat stroke; Malignant hyperthermia due to exercise\n'}


{'id': 'HP_0034733', 'url': 'http://purl.obolibrary.org/obo/HP_0034733', 'lbl': 'Anesthesic-triggered malignant hyperthermia', 'desc': 'label: Anesthesic-triggered malignant hyperthermia\ndefinition : Malignant hyperthermia that is characterized by a rapid increase in temperature to 39-42 degrees C in response to inhalational anesthetics such as halothane or to muscle relaxants such as succinylcholine.\nsynonyms :Malignant hyperthermia with anaesthesia; Malignant hyperthermia with anesthesia\n'}


{'id': 'HP_0034734', 'url': 'http://purl.obolibrary.org/obo/HP_0034734', 'lbl': 'Elevated CSF argininosuccinic acid concentration', 'desc': 'label: Elevated CSF argininosuccinic acid concentration\ndefinition : Concentration of argininosuccinic acid in the cerebrospinal fluid (CSF) above the upper limit of normal.\nsynonyms :Argininosuccinic acid high in CSF\n'}


{'id': 'HP_0034735', 'url': 'http://purl.obolibrary.org/obo/HP_0034735', 'lbl': 'Elevated CSF aspartylglucosamine concentration', 'desc': 'label: Elevated CSF aspartylglucosamine concentration\ndefinition : Concentration of aspartylglucosamine in the cerebrospinal fluid (CSF) above the upper limit of normal.\nsynonyms :Aspartylglucosamine high in CSF\n'}


{'id': 'HP_0034736', 'url': 'http://purl.obolibrary.org/obo/HP_0034736', 'lbl': 'Elevated circulating alpha-oxoadipic acid concentration', 'desc': 'label: Elevated circulating alpha-oxoadipic acid concentration\ndefinition : Concentration of alpha-oxoadipic acid in the blood above the upper limit of normal.\nsynonyms :Alpha-oxoadipic acid high in blood\n'}


{'id': 'HP_0034737', 'url': 'http://purl.obolibrary.org/obo/HP_0034737', 'lbl': 'Abnormal erythrocyte metabolite concentration', 'desc': 'label: Abnormal erythrocyte metabolite concentration\ndefinition : A deviation from the normal range of a metabolite in red blood cells.\nsynonyms :\n'}


{'id': 'HP_0034738', 'url': 'http://purl.obolibrary.org/obo/HP_0034738', 'lbl': 'Reduced erythrocyte glutathione concentration', 'desc': 'label: Reduced erythrocyte glutathione concentration\ndefinition : Concentration of glutathione in red blood cells below the lower limit of normal. Glutathione (GSH) is an important redox active biomolecule critical in the maintenance and regulation of cellular and organismal health.\nsynonyms :\n'}


{'id': 'HP_0034739', 'url': 'http://purl.obolibrary.org/obo/HP_0034739', 'lbl': 'Elevated CSF sarcosine concentration', 'desc': 'label: Elevated CSF sarcosine concentration\ndefinition : Concentration of sarcosine in the cerebrospinal fluid (CSF) above the upper limit of normal.\nsynonyms :Sarcosine high in CSF\n'}


{'id': 'HP_0034740', 'url': 'http://purl.obolibrary.org/obo/HP_0034740', 'lbl': 'Reduced CSF methionine concentration', 'desc': 'label: Reduced CSF methionine concentration\ndefinition : Concentration of methionine in the cerebrospinal fluid below the lower limit of normal.\nsynonyms :Methionine low in CSF\n'}


{'id': 'HP_0034741', 'url': 'http://purl.obolibrary.org/obo/HP_0034741', 'lbl': 'Elevated circulating homoarginine concentration', 'desc': 'label: Elevated circulating homoarginine concentration\ndefinition : Concentration of homoarginine in the blood circulation above the upper limit of normal.\nsynonyms :Homoarginine high in blood\n'}


{'id': 'HP_0034742', 'url': 'http://purl.obolibrary.org/obo/HP_0034742', 'lbl': 'Elevated urinary formiminoglutamic acid level', 'desc': 'label: Elevated urinary formiminoglutamic acid level\ndefinition : Level of formiminoglutamic acid in urine above the upper limit of normal.\nsynonyms :Formiminoglutamic acid high in urine\n'}


{'id': 'HP_0034743', 'url': 'http://purl.obolibrary.org/obo/HP_0034743', 'lbl': 'Elevated CSF proline concentration', 'desc': 'label: Elevated CSF proline concentration\ndefinition : Concentration of proline in the cerebrospinal fluid (CSF) above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034744', 'url': 'http://purl.obolibrary.org/obo/HP_0034744', 'lbl': 'Elevated urinary S-sulfocysteine level', 'desc': 'label: Elevated urinary S-sulfocysteine level\ndefinition : Level of S-sulfocysteine high in urine above the upper limit of normal.\nsynonyms :S-sulfocysteine high in urine\n'}


{'id': 'HP_0034745', 'url': 'http://purl.obolibrary.org/obo/HP_0034745', 'lbl': 'Elevated circulating S-sulfocysteine concentration', 'desc': 'label: Elevated circulating S-sulfocysteine concentration\ndefinition : Concentration of S-sulfocysteine in the blood circulation above the upper limit of normal.\nsynonyms :S-sulfocysteine high in blood\n'}


{'id': 'HP_0034746', 'url': 'http://purl.obolibrary.org/obo/HP_0034746', 'lbl': 'Sertoli cell hyperplasia', 'desc': 'label: Sertoli cell hyperplasia\ndefinition : Abnormal increase in the number of Sertoli cells in the testis.\nsynonyms :\n'}


{'id': 'HP_0034747', 'url': 'http://purl.obolibrary.org/obo/HP_0034747', 'lbl': 'CSF infectious agent', 'desc': 'label: CSF infectious agent\ndefinition : The presence of an infectious agent in the cerebrospinal fluid (CSF).\nsynonyms :\n'}


{'id': 'HP_0034748', 'url': 'http://purl.obolibrary.org/obo/HP_0034748', 'lbl': 'CSF mycobacteria', 'desc': 'label: CSF mycobacteria\ndefinition : Mycobacterium present in the cerebrospinal fluid (CSF). This feature can be ascertained by CSF microscopy.\nsynonyms :\n'}


{'id': 'HP_0034749', 'url': 'http://purl.obolibrary.org/obo/HP_0034749', 'lbl': 'Fungal bloodstream infection', 'desc': 'label: Fungal bloodstream infection\ndefinition : Detection of a fungal organism (such as candida or coccidioides) in the blood stream.\nsynonyms :Fungi in blood\n'}


{'id': 'HP_0034750', 'url': 'http://purl.obolibrary.org/obo/HP_0034750', 'lbl': 'Supraclavicular lymphadenopathy', 'desc': 'label: Supraclavicular lymphadenopathy\ndefinition : Enlarged lymph node located just above the clavicle (collarbone).\nsynonyms :\n'}


{'id': 'HP_0034751', 'url': 'http://purl.obolibrary.org/obo/HP_0034751', 'lbl': 'Inguinal lymphadenopathy', 'desc': 'label: Inguinal lymphadenopathy\ndefinition : Enlarged lymph node located in the inguinal region (groin).\nsynonyms :\n'}


{'id': 'HP_0034752', 'url': 'http://purl.obolibrary.org/obo/HP_0034752', 'lbl': 'Axillary lymphadenopathy', 'desc': 'label: Axillary lymphadenopathy\ndefinition : Enlarged lymph node located in the axillary region (armpit).\nsynonyms :\n'}


{'id': 'HP_0034753', 'url': 'http://purl.obolibrary.org/obo/HP_0034753', 'lbl': 'Positive Murphy sign', 'desc': "label: Positive Murphy sign\ndefinition : Murphy's sign is elicited in patients with acute cholecystitis by asking the patient to take in and hold a deep breath while palpating the subcostal region. In practice, Murphy's sign is performed by palpating the subcostal region during inspiration. If pain is elicited and the patient suddenly stops their inspiratory effort, a positive Murphy's sign has been elicited.\nsynonyms :Murphy's sign; Murphy's sign positive; Sweeney's sign\n"}


{'id': 'HP_0034754', 'url': 'http://purl.obolibrary.org/obo/HP_0034754', 'lbl': 'Bilious emesis', 'desc': 'label: Bilious emesis\ndefinition : Vomiting whereby the vomit has the color of bile, yellowish-green.\nsynonyms :\n'}


{'id': 'HP_0034755', 'url': 'http://purl.obolibrary.org/obo/HP_0034755', 'lbl': 'Ameliorated by NSAID', 'desc': 'label: Ameliorated by NSAID\ndefinition : Applies to a sign or symptom that is improved or made more bearable by treatment with a nonsteroidal anti-inflammatory drug (NSAID).\nsynonyms :Ameliorated by nonsteroidal anti-inflammatory drug\n'}


{'id': 'HP_0034756', 'url': 'http://purl.obolibrary.org/obo/HP_0034756', 'lbl': 'Maternal exposure history', 'desc': 'label: Maternal exposure history\ndefinition : A history of exposure during pregnancy of the mother of a fetus or child to a medication or other substance.\nsynonyms :\n'}


{'id': 'HP_0034757', 'url': 'http://purl.obolibrary.org/obo/HP_0034757', 'lbl': 'Maternal barbiturate exposure', 'desc': 'label: Maternal barbiturate exposure\ndefinition : A history of exposure during pregnancy of the mother of a fetus or child to barbiturate medications such as phenobarbital. Barbiturates are used medically as anxiolytics, hypnotics, and anticonvulsants.\nsynonyms :Maternal barbiturate use\n'}


{'id': 'HP_0034758', 'url': 'http://purl.obolibrary.org/obo/HP_0034758', 'lbl': 'Maternal narcotic exposure', 'desc': 'label: Maternal narcotic exposure\ndefinition : A history of exposure during pregnancy of the mother of a fetus or child to narcotic medications such as morphine or codeine. Narcotics are used medically to treat moderate or severe pain.\nsynonyms :\n'}


{'id': 'HP_0034759', 'url': 'http://purl.obolibrary.org/obo/HP_0034759', 'lbl': 'Ameliorated by ethosuximide', 'desc': 'label: Ameliorated by ethosuximide\ndefinition : Applies to a sign or symptom that is improved or made more bearable by administration of ethosuximide. Ethosuximide is most often used to treat absence seizures.\nsynonyms :\n'}


{'id': 'HP_0034760', 'url': 'http://purl.obolibrary.org/obo/HP_0034760', 'lbl': 'Reduced epidermal extracellular matrix protein 1 protein expression', 'desc': 'label: Reduced epidermal extracellular matrix protein 1 protein expression\ndefinition : Lower than normal amount of extracellular matrix protein 1 (ECM1) in the epidermis.\nsynonyms :Reduced epidermal ECM1 protein expression\n'}


{'id': 'HP_0034761', 'url': 'http://purl.obolibrary.org/obo/HP_0034761', 'lbl': 'Neurofibroma by anatomical location', 'desc': 'label: Neurofibroma by anatomical location\ndefinition : Neurofibroma categorized according to the anatomical site of origin.\nsynonyms :\n'}


{'id': 'HP_0034762', 'url': 'http://purl.obolibrary.org/obo/HP_0034762', 'lbl': 'Tongue neurofibroma', 'desc': 'label: Tongue neurofibroma\ndefinition : A neurofibroma (benign peripheral nerve sheath tumor) localized in the tongue.\nsynonyms :\n'}


{'id': 'HP_0034763', 'url': 'http://purl.obolibrary.org/obo/HP_0034763', 'lbl': 'Cardiac neurofibroma', 'desc': 'label: Cardiac neurofibroma\ndefinition : A neurofibroma (benign peripheral nerve sheath tumor) localized in the heart.\nsynonyms :\n'}


{'id': 'HP_0034764', 'url': 'http://purl.obolibrary.org/obo/HP_0034764', 'lbl': 'Gastric neurofibroma', 'desc': 'label: Gastric neurofibroma\ndefinition : A neurofibroma (benign peripheral nerve sheath tumor) localized in the stomach.\nsynonyms :\n'}


{'id': 'HP_0034765', 'url': 'http://purl.obolibrary.org/obo/HP_0034765', 'lbl': 'Renal neurofibroma', 'desc': 'label: Renal neurofibroma\ndefinition : A neurofibroma (benign peripheral nerve sheath tumor) localized in the kidney.\nsynonyms :\n'}


{'id': 'HP_0034766', 'url': 'http://purl.obolibrary.org/obo/HP_0034766', 'lbl': 'Muscle fiber polyglucosan inclusion bodies', 'desc': 'label: Muscle fiber polyglucosan inclusion bodies\ndefinition : Accumulation of a poorly branched and poorly spherical amylopectin-like glycogen (polyglucosan) in muscle fibers.\nsynonyms :Muscle biopsy: polyglucosan accumulation\n'}


{'id': 'HP_0034767', 'url': 'http://purl.obolibrary.org/obo/HP_0034767', 'lbl': 'Abnormal rete ridge morphology', 'desc': 'label: Abnormal rete ridge morphology\ndefinition : Abnormal structure of the rete ridges (also known as rete pegs), which are\ndownward projections of epithelium surrounding the connective tissue papillae in between the dermal papillae.\nsynonyms :\n'}


{'id': 'HP_0034768', 'url': 'http://purl.obolibrary.org/obo/HP_0034768', 'lbl': 'Rete ridge elongation', 'desc': 'label: Rete ridge elongation\ndefinition : Increased length of the rete rdiges of the epidermis.\nsynonyms :Elongation of rete ridges; Rete ridges elongated\n'}


{'id': 'HP_0034769', 'url': 'http://purl.obolibrary.org/obo/HP_0034769', 'lbl': 'Pulmonary Langerhans cell histiocytosis', 'desc': 'label: Pulmonary Langerhans cell histiocytosis\ndefinition : Accumulation of monoclonal CD1a-positive Langerhans cells in the bronchioles and alveolar interstitium that can cause damage to the lungs.\nsynonyms :\n'}


{'id': 'HP_0034770', 'url': 'http://purl.obolibrary.org/obo/HP_0034770', 'lbl': 'Lumbar hypolordosis', 'desc': 'label: Lumbar hypolordosis\ndefinition : Flattening of a curve in the spine in the lumbar (lower back) region.\nsynonyms :Reduced lumbar lordosis\n'}


{'id': 'HP_0034771', 'url': 'http://purl.obolibrary.org/obo/HP_0034771', 'lbl': 'Battle sign', 'desc': "label: Battle sign\ndefinition : Battle sign is bruising over the mastoid process that is typically the result of head trauma. It is retroauricular or mastoid ecchymosis that is typically the result of head trauma. Battle sign typically requires significant head trauma and may indicate significant internal injury to the brain and not just the posterior cranial vault or mastoid.\nsynonyms :Battle sign bruise; Battle's sign\n"}


{'id': 'HP_0034772', 'url': 'http://purl.obolibrary.org/obo/HP_0034772', 'lbl': 'Decreased skull base length', 'desc': 'label: Decreased skull base length\ndefinition : Reduced anterioposterior dimension of the skull base.\nsynonyms :Decreased cranial base length; Short skull base\n'}


{'id': 'HP_0034773', 'url': 'http://purl.obolibrary.org/obo/HP_0034773', 'lbl': 'Oscillopsia', 'desc': 'label: Oscillopsia\ndefinition : A visual disturbance in which objects in the visual field appear to oscillate (jump, jiggle, vibrate).\nsynonyms :\n'}


{'id': 'HP_0034774', 'url': 'http://purl.obolibrary.org/obo/HP_0034774', 'lbl': 'Decreased blink rate', 'desc': 'label: Decreased blink rate\ndefinition : The frequency with which the eye is blinked is below the lower limit of normal.\nsynonyms :Blinking reduced\n'}


{'id': 'HP_0034775', 'url': 'http://purl.obolibrary.org/obo/HP_0034775', 'lbl': 'Abnormal blink rate', 'desc': 'label: Abnormal blink rate\ndefinition : A deviation from the normal frequency of blinking the eye.\nsynonyms :\n'}


{'id': 'HP_0034776', 'url': 'http://purl.obolibrary.org/obo/HP_0034776', 'lbl': 'Elevated blink rate', 'desc': 'label: Elevated blink rate\ndefinition : The frequecy with which the eye is blinked is above the upper limit of normal.\nsynonyms :\n'}


{'id': 'HP_0034777', 'url': 'http://purl.obolibrary.org/obo/HP_0034777', 'lbl': 'Purulent sputum', 'desc': 'label: Purulent sputum\ndefinition : Sputum contains pus.\nsynonyms :\n'}


{'id': 'HP_0034778', 'url': 'http://purl.obolibrary.org/obo/HP_0034778', 'lbl': 'Maternal hyperthyroidism', 'desc': 'label: Maternal hyperthyroidism\ndefinition : The mother of a fetus or index patient has a history of hyperthyroidism during the corresponding pregnancy.\nsynonyms :\n'}


{'id': 'HP_0034779', 'url': 'http://purl.obolibrary.org/obo/HP_0034779', 'lbl': 'Perineal', 'desc': 'label: Perineal\ndefinition : Applies to an abnormality that affects the perineum (the region of skin between the genitals and the anus).\nsynonyms :Perineal distribution to finding; Perineal location\n'}


{'id': 'HP_0034780', 'url': 'http://purl.obolibrary.org/obo/HP_0034780', 'lbl': 'Gadolinium exposure', 'desc': 'label: Gadolinium exposure\ndefinition : History of exposure to gadolinium, a contrast medium often used for magnetic resonance imaging.\nsynonyms :\n'}


{'id': 'HP_0034781', 'url': 'http://purl.obolibrary.org/obo/HP_0034781', 'lbl': 'Purulent parotid gland drainage', 'desc': 'label: Purulent parotid gland drainage\ndefinition : Excretion of pus (purulent discharge) from the opening of the parotid duct.\nsynonyms :Purulent Stensen duct drainage\n'}


{'id': 'HP_0040004', 'url': 'http://purl.obolibrary.org/obo/HP_0040004', 'lbl': 'Abnormality of corneal shape', 'desc': 'label: Abnormality of corneal shape\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0040006', 'url': 'http://purl.obolibrary.org/obo/HP_0040006', 'lbl': 'Mortality/Aging', 'desc': 'label: Mortality/Aging\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0040007', 'url': 'http://purl.obolibrary.org/obo/HP_0040007', 'lbl': 'Absent pigmentation of chest', 'desc': 'label: Absent pigmentation of chest\ndefinition : Lack of skin pigmentation (coloring) of the chest.\nsynonyms :Lack of skin coloring on chest; Lack of skin colouring on chest\n'}