{'id': 'HP_0001912', 'url': 'http://purl.obolibrary.org/obo/HP_0001912', 'lbl': 'Abnormal basophil morphology', 'desc': 'label: Abnormal basophil morphology\ndefinition : Any structural abnormality or abnormal count of basophils.\nsynonyms :Abnormality of basophils\n'}


{'id': 'HP_0001913', 'url': 'http://purl.obolibrary.org/obo/HP_0001913', 'lbl': 'Granulocytopenia', 'desc': 'label: Granulocytopenia\ndefinition : An abnormally reduced number of granulocytes in the blood.\nsynonyms :\n'}


{'id': 'HP_0001915', 'url': 'http://purl.obolibrary.org/obo/HP_0001915', 'lbl': 'Aplastic anemia', 'desc': 'label: Aplastic anemia\ndefinition : Aplastic anemia is defined as pancytopenia with a hypocellular marrow.\nsynonyms :Aplastic anaemia\n'}


{'id': 'HP_0001917', 'url': 'http://purl.obolibrary.org/obo/HP_0001917', 'lbl': 'Renal amyloidosis', 'desc': 'label: Renal amyloidosis\ndefinition : A form of amyloidosis that affects the kidney. On hematoxylin and eosin stain, amyloid is identified as extracellular amorphous material that is lightly eosinophilic. These deposits often stain weakly for periodic acid Schiff (PAS), demonstrate a blue-to-gray hue on the trichrome stain and are typically negative on the Jones methenamine silver (JMS) stain. These tinctorial properties contrast with the histologic appearance of collagen, a major component of basement membranes, mesangial matrix and areas of sclerosis, which demonstrates strong positivity for PAS and JMS (See Figure 1 of PMID:25852856).\nsynonyms :\n'}


{'id': 'HP_0001919', 'url': 'http://purl.obolibrary.org/obo/HP_0001919', 'lbl': 'Acute kidney injury', 'desc': 'label: Acute kidney injury\ndefinition : Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia).\nsynonyms :Acute kidney failure; Acute renal failure\n'}


{'id': 'HP_0001920', 'url': 'http://purl.obolibrary.org/obo/HP_0001920', 'lbl': 'Renal artery stenosis', 'desc': 'label: Renal artery stenosis\ndefinition : The presence of stenosis of the renal artery.\nsynonyms :Narrowing of kidney artery\n'}


{'id': 'HP_0001922', 'url': 'http://purl.obolibrary.org/obo/HP_0001922', 'lbl': 'Vacuolated lymphocytes', 'desc': 'label: Vacuolated lymphocytes\ndefinition : The presence of clear, sharply defined vacuoles in the lymphocyte cytoplasm.\nsynonyms :Enlarged lysosomal vacuoles in lymphocytes; Vacuolated blood lymphocytes\n'}


{'id': 'HP_0001923', 'url': 'http://purl.obolibrary.org/obo/HP_0001923', 'lbl': 'Reticulocytosis', 'desc': 'label: Reticulocytosis\ndefinition : An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation.\nsynonyms :Increased immature red blood cells; Increased number of immature red blood cells; Increased reticulocyte count; Increased reticulocytes\n'}


{'id': 'HP_0001924', 'url': 'http://purl.obolibrary.org/obo/HP_0001924', 'lbl': 'Sideroblastic anemia', 'desc': 'label: Sideroblastic anemia\ndefinition : Sideroblastic anemia results from a defect in the incorporation of iron into the heme molecule. A sideroblast is an erythroblast that has stainable deposits of iron in cytoplasm (this can be demonstrated by Prussian blue staining).\nsynonyms :Hypersideremic anaemia; Hypersideremic anemia; Sideroblastic anaemia\n'}


{'id': 'HP_0001927', 'url': 'http://purl.obolibrary.org/obo/HP_0001927', 'lbl': 'Acanthocytosis', 'desc': 'label: Acanthocytosis\ndefinition : Acanthocytosis is a type of poikilocytosis characterized by the presence of spikes on the cell surface. The cells have an irregular shape resembling many-pointed stars.\nsynonyms :Acanthocytes; Red cell acanthocytosis\n'}


{'id': 'HP_0001928', 'url': 'http://purl.obolibrary.org/obo/HP_0001928', 'lbl': 'Abnormality of coagulation', 'desc': 'label: Abnormality of coagulation\ndefinition : An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot.\nsynonyms :Abnormal blood coagulation studies; Coagulation abnormalities; Coagulation abnormality; Haemorrhagic disorders; Blood coagulation disorder\n'}


{'id': 'HP_0001929', 'url': 'http://purl.obolibrary.org/obo/HP_0001929', 'lbl': 'Reduced factor XI activity', 'desc': 'label: Reduced factor XI activity\ndefinition : Decreased activity of coagulation factor XI. Factor XI, also known as plasma thromboplastin antecedent, is a serine proteinase that activates factor IX.\nsynonyms :Low factor XI activity; Factor XI deficiency\n'}


{'id': 'HP_0001930', 'url': 'http://purl.obolibrary.org/obo/HP_0001930', 'lbl': 'Nonspherocytic hemolytic anemia', 'desc': 'label: Nonspherocytic hemolytic anemia\ndefinition : \nsynonyms :Nonspherocytic hemolytic anaemia\n'}


{'id': 'HP_0001931', 'url': 'http://purl.obolibrary.org/obo/HP_0001931', 'lbl': 'Hypochromic anemia', 'desc': 'label: Hypochromic anemia\ndefinition : A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes.\nsynonyms :Hypochromic anaemia\n'}


{'id': 'HP_0001933', 'url': 'http://purl.obolibrary.org/obo/HP_0001933', 'lbl': 'Subcutaneous hemorrhage', 'desc': 'label: Subcutaneous hemorrhage\ndefinition : This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses).\nsynonyms :Bleeding below the skin; Subcutaneous haemorrhage\n'}


{'id': 'HP_0001934', 'url': 'http://purl.obolibrary.org/obo/HP_0001934', 'lbl': 'Persistent bleeding after trauma', 'desc': 'label: Persistent bleeding after trauma\ndefinition : \nsynonyms :Excessive bleeding after minor trauma; Frequent bleeding with trauma; Prolonged bleeding after minor trauma\n'}


{'id': 'HP_0001935', 'url': 'http://purl.obolibrary.org/obo/HP_0001935', 'lbl': 'Microcytic anemia', 'desc': 'label: Microcytic anemia\ndefinition : A kind of anemia in which the volume of the red blood cells is reduced.\nsynonyms :Microcytic anaemia\n'}


{'id': 'HP_0001937', 'url': 'http://purl.obolibrary.org/obo/HP_0001937', 'lbl': 'Microangiopathic hemolytic anemia', 'desc': 'label: Microangiopathic hemolytic anemia\ndefinition : \nsynonyms :Microangiopathic hemolytic anaemia\n'}


{'id': 'HP_0001939', 'url': 'http://purl.obolibrary.org/obo/HP_0001939', 'lbl': 'Abnormality of metabolism/homeostasis', 'desc': 'label: Abnormality of metabolism/homeostasis\ndefinition : \nsynonyms :Laboratory abnormality; Metabolism abnormality\n'}


{'id': 'HP_0001941', 'url': 'http://purl.obolibrary.org/obo/HP_0001941', 'lbl': 'Acidosis', 'desc': 'label: Acidosis\ndefinition : Abnormal acid accumulation or depletion of base.\nsynonyms :\n'}


{'id': 'HP_0001942', 'url': 'http://purl.obolibrary.org/obo/HP_0001942', 'lbl': 'Metabolic acidosis', 'desc': 'label: Metabolic acidosis\ndefinition : Metabolic acidosis (MA) is characterized by a fall in blood pH due to a reduction of serum bicarbonate concentration. This can occur as a result of either the accumulation of acids (high anion gap MA) or the loss of bicarbonate from the gastrointestinal tract or the kidney (hyperchloremic MA). By definition, MA is not due to a respirary cause.\nsynonyms :\n'}


{'id': 'HP_0001943', 'url': 'http://purl.obolibrary.org/obo/HP_0001943', 'lbl': 'Hypoglycemia', 'desc': 'label: Hypoglycemia\ndefinition : A decreased concentration of glucose in the blood.\nsynonyms :Hypoglycaemia; Low blood sugar\n'}


{'id': 'HP_0001944', 'url': 'http://purl.obolibrary.org/obo/HP_0001944', 'lbl': 'Dehydration', 'desc': 'label: Dehydration\ndefinition : \nsynonyms :Dehydration; Exsiccosis\n'}


{'id': 'HP_0001945', 'url': 'http://purl.obolibrary.org/obo/HP_0001945', 'lbl': 'Fever', 'desc': 'label: Fever\ndefinition : Body temperature elevated above the normal range.\nsynonyms :Fever; Hyperthermia; Pyrexia\n'}


{'id': 'HP_0001946', 'url': 'http://purl.obolibrary.org/obo/HP_0001946', 'lbl': 'Ketosis', 'desc': 'label: Ketosis\ndefinition : Presence of elevated levels of ketone bodies in the body.\nsynonyms :High levels of ketone bodies; Hyperketosis\n'}


{'id': 'HP_0001947', 'url': 'http://purl.obolibrary.org/obo/HP_0001947', 'lbl': 'Renal tubular acidosis', 'desc': 'label: Renal tubular acidosis\ndefinition : Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia, potentially leading to complications including hypokalemia, hypercalcinuria, nephrolithiasis and nephrocalcinosis.\nsynonyms :Accumulation of acid in body due to kidney problem\n'}


{'id': 'HP_0001948', 'url': 'http://purl.obolibrary.org/obo/HP_0001948', 'lbl': 'Alkalosis', 'desc': 'label: Alkalosis\ndefinition : Depletion of acid or accumulation base in the body fluids.\nsynonyms :\n'}


{'id': 'HP_0001949', 'url': 'http://purl.obolibrary.org/obo/HP_0001949', 'lbl': 'Hypokalemic alkalosis', 'desc': 'label: Hypokalemic alkalosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0001950', 'url': 'http://purl.obolibrary.org/obo/HP_0001950', 'lbl': 'Respiratory alkalosis', 'desc': 'label: Respiratory alkalosis\ndefinition : Alkalosis due to excess loss of carbon dioxide from the body.\nsynonyms :\n'}


{'id': 'HP_0001951', 'url': 'http://purl.obolibrary.org/obo/HP_0001951', 'lbl': 'Episodic ammonia intoxication', 'desc': 'label: Episodic ammonia intoxication\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0001952', 'url': 'http://purl.obolibrary.org/obo/HP_0001952', 'lbl': 'Glucose intolerance', 'desc': 'label: Glucose intolerance\ndefinition : Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM).\nsynonyms :Abnormal glucose tolerance; Glucose intolerance\n'}


{'id': 'HP_0001953', 'url': 'http://purl.obolibrary.org/obo/HP_0001953', 'lbl': 'Diabetic ketoacidosis', 'desc': 'label: Diabetic ketoacidosis\ndefinition : A type of diabetic metabolic abnormality with an accumulation of ketone bodies.\nsynonyms :Diabetic ketosis\n'}


{'id': 'HP_0001954', 'url': 'http://purl.obolibrary.org/obo/HP_0001954', 'lbl': 'Recurrent fever', 'desc': 'label: Recurrent fever\ndefinition : Periodic (episodic or recurrent) bouts of fever.\nsynonyms :Episodic fever; Hyperthermia, episodic; Increased body temperature, episodic; Intermittent fever\n'}


{'id': 'HP_0001955', 'url': 'http://purl.obolibrary.org/obo/HP_0001955', 'lbl': 'Unexplained fevers', 'desc': 'label: Unexplained fevers\ndefinition : Episodes of fever for which no infectious cause can be identified.\nsynonyms :Unexplained fevers\n'}


{'id': 'HP_0001956', 'url': 'http://purl.obolibrary.org/obo/HP_0001956', 'lbl': 'Truncal obesity', 'desc': 'label: Truncal obesity\ndefinition : Obesity located preferentially in the trunk of the body as opposed to the extremities.\nsynonyms :Centripetal obesity; Truncal obesity\n'}


{'id': 'HP_0001958', 'url': 'http://purl.obolibrary.org/obo/HP_0001958', 'lbl': 'Nonketotic hypoglycemia', 'desc': 'label: Nonketotic hypoglycemia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0001959', 'url': 'http://purl.obolibrary.org/obo/HP_0001959', 'lbl': 'Polydipsia', 'desc': 'label: Polydipsia\ndefinition : Excessive thirst manifested by excessive fluid intake.\nsynonyms :Extreme thirst\n'}


{'id': 'HP_0001960', 'url': 'http://purl.obolibrary.org/obo/HP_0001960', 'lbl': 'Hypokalemic metabolic alkalosis', 'desc': 'label: Hypokalemic metabolic alkalosis\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0001961', 'url': 'http://purl.obolibrary.org/obo/HP_0001961', 'lbl': 'Hypoplastic heart', 'desc': 'label: Hypoplastic heart\ndefinition : \nsynonyms :Small heart; Underdeveloped heart\n'}


{'id': 'HP_0001962', 'url': 'http://purl.obolibrary.org/obo/HP_0001962', 'lbl': 'Palpitations', 'desc': 'label: Palpitations\ndefinition : A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia.\nsynonyms :Heart palpitations; Missed heart beat; Palpitations; Skipped heart beat\n'}


{'id': 'HP_0001963', 'url': 'http://purl.obolibrary.org/obo/HP_0001963', 'lbl': 'Abnormal speech discrimination', 'desc': 'label: Abnormal speech discrimination\ndefinition : A type of hearing impairment prominently characterized by a difficulty in understanding speech, rather than an inability to hear speech. Poor speech discrimination is a very common symptom of high frequency hearing loss.\nsynonyms :Abnormal speech discrimination; Poor speech discrimination\n'}


{'id': 'HP_0001964', 'url': 'http://purl.obolibrary.org/obo/HP_0001964', 'lbl': 'Aplasia/Hypoplasia of metatarsal bones', 'desc': 'label: Aplasia/Hypoplasia of metatarsal bones\ndefinition : Absence or underdevelopment of the metatarsal bones.\nsynonyms :Absent or hypoplastic metatarsal; Absent/hypoplastic metacarpals; Absent/hypoplastic metatarsals; Absent/small long bone of foot; Absent/underdeveloped long bone of foot; Aplastic/hypoplastic metatarsals\n'}


{'id': 'HP_0001965', 'url': 'http://purl.obolibrary.org/obo/HP_0001965', 'lbl': 'Abnormal scalp morphology', 'desc': 'label: Abnormal scalp morphology\ndefinition : Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows.\nsynonyms :Abnormality of the scalp; Anomaly of scalp\n'}


{'id': 'HP_0001966', 'url': 'http://purl.obolibrary.org/obo/HP_0001966', 'lbl': 'Abnormal glomerular mesangium morphology', 'desc': 'label: Abnormal glomerular mesangium morphology\ndefinition : An abnormality of the mesangium, i.e., of the central part of the renal glomerulus between capillaries.\nsynonyms :Abnormality glomerular mesangium morphology; Abnormality of the glomerular mesangium; Mesangial abnormality\n'}


{'id': 'HP_0001967', 'url': 'http://purl.obolibrary.org/obo/HP_0001967', 'lbl': 'Diffuse mesangial sclerosis', 'desc': 'label: Diffuse mesangial sclerosis\ndefinition : Diffuse sclerosis of the mesangium, as manifestated by diffuse mesangial matrix expansion.\nsynonyms :Diffuse mesangial sclerosis glomerulopathy; Mesangial sclerosis\n'}


{'id': 'HP_0001969', 'url': 'http://purl.obolibrary.org/obo/HP_0001969', 'lbl': 'Abnormal tubulointerstitial morphology', 'desc': 'label: Abnormal tubulointerstitial morphology\ndefinition : An abnormality that involves the tubules and interstitial tissue of the kidney.\nsynonyms :Tubulointerstitial abnormality; Tubulointerstitial nephropathy\n'}


{'id': 'HP_0001970', 'url': 'http://purl.obolibrary.org/obo/HP_0001970', 'lbl': 'Tubulointerstitial nephritis', 'desc': 'label: Tubulointerstitial nephritis\ndefinition : A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.\nsynonyms :Interstitial nephritis; Nephritis, Tubulointerstitial\n'}


{'id': 'HP_0001971', 'url': 'http://purl.obolibrary.org/obo/HP_0001971', 'lbl': 'Hypersplenism', 'desc': 'label: Hypersplenism\ndefinition : A malfunctioning of the spleen in which it prematurely destroys red blood cells.\nsynonyms :\n'}


{'id': 'HP_0001972', 'url': 'http://purl.obolibrary.org/obo/HP_0001972', 'lbl': 'Macrocytic anemia', 'desc': 'label: Macrocytic anemia\ndefinition : A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).\nsynonyms :Macrocytic anaemia\n'}


{'id': 'HP_0001973', 'url': 'http://purl.obolibrary.org/obo/HP_0001973', 'lbl': 'Autoimmune thrombocytopenia', 'desc': 'label: Autoimmune thrombocytopenia\ndefinition : The presence of thrombocytopenia in combination with detection of antiplatelet antibodies.\nsynonyms :Idiopathic thrombocytopenia; Immune thrombocytopenia; Idiopathic thrombocytopenic purpura\n'}


{'id': 'HP_0001974', 'url': 'http://purl.obolibrary.org/obo/HP_0001974', 'lbl': 'Leukocytosis', 'desc': 'label: Leukocytosis\ndefinition : An abnormal increase in the number of leukocytes in the blood.\nsynonyms :Elevated white blood count; High white blood count; Increased blood leukocyte number\n'}


{'id': 'HP_0001975', 'url': 'http://purl.obolibrary.org/obo/HP_0001975', 'lbl': 'Decreased platelet glycoprotein IIb-IIIa', 'desc': 'label: Decreased platelet glycoprotein IIb-IIIa\ndefinition : Decreased cell membrane concentration of glycoprotein IIb-IIIa.\nsynonyms :Reduced level of platelet glycoprotein IIb/IIIa complex; Glanzmann thrombasthenia\n'}


{'id': 'HP_0001976', 'url': 'http://purl.obolibrary.org/obo/HP_0001976', 'lbl': 'Reduced antithrombin III activity', 'desc': 'label: Reduced antithrombin III activity\ndefinition : An abnormality of coagulation related to a decreased concentration of antithrombin-III.\nsynonyms :Anti-thrombin III deficiency; Antithrombin III deficiency; Decreased antithrombin III\n'}


{'id': 'HP_0001977', 'url': 'http://purl.obolibrary.org/obo/HP_0001977', 'lbl': 'Abnormal thrombosis', 'desc': 'label: Abnormal thrombosis\ndefinition : Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis).\nsynonyms :Abnormal blood clot; Abnormal blood clotting\n'}


{'id': 'HP_0001978', 'url': 'http://purl.obolibrary.org/obo/HP_0001978', 'lbl': 'Extramedullary hematopoiesis', 'desc': 'label: Extramedullary hematopoiesis\ndefinition : The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms.\nsynonyms :Extramedullary erythropoiesis\n'}


{'id': 'HP_0001980', 'url': 'http://purl.obolibrary.org/obo/HP_0001980', 'lbl': 'Megaloblastic bone marrow', 'desc': 'label: Megaloblastic bone marrow\ndefinition : Abnormal increased number of megaloblasts in the bone marrow.\nsynonyms :\n'}


{'id': 'HP_0001981', 'url': 'http://purl.obolibrary.org/obo/HP_0001981', 'lbl': 'Schistocytosis', 'desc': 'label: Schistocytosis\ndefinition : The presence of an abnormal number of fragmented red blood cells (schistocytes) in the blood.\nsynonyms :Schistocytes\n'}


{'id': 'HP_0001982', 'url': 'http://purl.obolibrary.org/obo/HP_0001982', 'lbl': 'Sea-blue histiocytosis', 'desc': 'label: Sea-blue histiocytosis\ndefinition : An abnormality of histiocytes, in which the cells take on a sea blue appearance due to abnormally increased lipid content. Histiocytes are a type of macrophage. Sea-blue histiocytes are typically large macrophages from 20 to 60 micrometers in diameter with a single eccentric nucleus whose cytoplasm if packed with sea-blue or blue-green granules when stained with Wright-Giemsa.\nsynonyms :Sea-blue histiocyte\n'}


{'id': 'HP_0001983', 'url': 'http://purl.obolibrary.org/obo/HP_0001983', 'lbl': 'Reduced lymphocyte surface expression of CD43', 'desc': 'label: Reduced lymphocyte surface expression of CD43\ndefinition : A reduction in the expression of CD43 on the cell surface of lymphocytes.\nsynonyms :Cd43 defectively expressed on surface of blood cells; Reduced lymphocyte surface expression of sialophorin\n'}


{'id': 'HP_0001984', 'url': 'http://purl.obolibrary.org/obo/HP_0001984', 'lbl': 'Intolerance to protein', 'desc': 'label: Intolerance to protein\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0001985', 'url': 'http://purl.obolibrary.org/obo/HP_0001985', 'lbl': 'Hypoketotic hypoglycemia', 'desc': 'label: Hypoketotic hypoglycemia\ndefinition : A decreased concentration of glucose in the blood associated with a reduced concentration of ketone bodies.\nsynonyms :Hypoglycemia, hypoketotic\n'}


{'id': 'HP_0001986', 'url': 'http://purl.obolibrary.org/obo/HP_0001986', 'lbl': 'Hypertonic dehydration', 'desc': 'label: Hypertonic dehydration\ndefinition : \nsynonyms :Hyperosmolar dehydration\n'}


{'id': 'HP_0001987', 'url': 'http://purl.obolibrary.org/obo/HP_0001987', 'lbl': 'Hyperammonemia', 'desc': 'label: Hyperammonemia\ndefinition : An increased concentration of ammonia in the blood.\nsynonyms :High blood ammonia levels\n'}


{'id': 'HP_0001988', 'url': 'http://purl.obolibrary.org/obo/HP_0001988', 'lbl': 'Recurrent hypoglycemia', 'desc': 'label: Recurrent hypoglycemia\ndefinition : Recurrent episodes of decreased concentration of glucose in the blood.\nsynonyms :Hypoglycemic episodes; Recurrent hypoglycaemia; Recurrent hypoglycemic episodes; Recurrent low blood sugar levels; hypoglycaemia, recurrent; hypoglycemia, recurrent\n'}


{'id': 'HP_0001989', 'url': 'http://purl.obolibrary.org/obo/HP_0001989', 'lbl': 'Fetal akinesia sequence', 'desc': 'label: Fetal akinesia sequence\ndefinition : Decreased fetal activity associated with multiple joint contractures, facial anomalies and pulmonary hypoplasia. Ultrasound examination may reveal polyhydramnios, ankylosis, scalp edema, and decreased chest movements (reflecting pulmonary hypoplasia).\nsynonyms :Foetal akinesia sequence; Early severe fetal akinesia sequence; Early severe foetal akinesia sequence; Fetal akinesia; Foetal akinesia\n'}


{'id': 'HP_0001991', 'url': 'http://purl.obolibrary.org/obo/HP_0001991', 'lbl': 'Aplasia/Hypoplasia of toe', 'desc': 'label: Aplasia/Hypoplasia of toe\ndefinition : Absence or hypoplasia of toes.\nsynonyms :Absent/small toe; Absent/underdeveloped toe; Aplastic/hypoplastic toe phalanges; Absent/hypoplastic toes\n'}


{'id': 'HP_0001992', 'url': 'http://purl.obolibrary.org/obo/HP_0001992', 'lbl': 'Organic aciduria', 'desc': 'label: Organic aciduria\ndefinition : Excretion of non-amino organic acids in urine.\nsynonyms :\n'}


{'id': 'HP_0001993', 'url': 'http://purl.obolibrary.org/obo/HP_0001993', 'lbl': 'Ketoacidosis', 'desc': 'label: Ketoacidosis\ndefinition : Acidosis resulting from accumulation of ketone bodies.\nsynonyms :\n'}


{'id': 'HP_0001994', 'url': 'http://purl.obolibrary.org/obo/HP_0001994', 'lbl': 'Renal Fanconi syndrome', 'desc': 'label: Renal Fanconi syndrome\ndefinition : An inability of the tubules in the kidney to reabsorb small molecules, causing increased urinary loss of electrolytes (sodium, potassium, bicarbonate), minerals, glucose, amino acids, and water.\nsynonyms :De toni-fanconi-debre syndrome; Renal tubular fanconi syndrome\n'}


{'id': 'HP_0001995', 'url': 'http://purl.obolibrary.org/obo/HP_0001995', 'lbl': 'Hyperchloremic acidosis', 'desc': 'label: Hyperchloremic acidosis\ndefinition : Acidosis (pH less than 7.35) that develops with an increase in ionic chloride.\nsynonyms :\n'}


{'id': 'HP_0001996', 'url': 'http://purl.obolibrary.org/obo/HP_0001996', 'lbl': 'Chronic metabolic acidosis', 'desc': 'label: Chronic metabolic acidosis\ndefinition : Longstanding metabolic acidosis.\nsynonyms :\n'}


{'id': 'HP_0001997', 'url': 'http://purl.obolibrary.org/obo/HP_0001997', 'lbl': 'Gout', 'desc': 'label: Gout\ndefinition : Recurrent attacks of acute inflammatory arthritis of a joint or set of joints caused by elevated levels of uric acid in the blood which crystallize and are deposited in joints, tendons, and surrounding tissues.\nsynonyms :Gouty arthritis\n'}


{'id': 'HP_0001998', 'url': 'http://purl.obolibrary.org/obo/HP_0001998', 'lbl': 'Neonatal hypoglycemia', 'desc': 'label: Neonatal hypoglycemia\ndefinition : \nsynonyms :Low blood sugar in newborn\n'}


{'id': 'HP_0001999', 'url': 'http://purl.obolibrary.org/obo/HP_0001999', 'lbl': 'Abnormal facial shape', 'desc': 'label: Abnormal facial shape\ndefinition : An abnormal morphology (form) of the face or its components.\nsynonyms :Deformity of face; Malformation of face; Abnormal facial shape; Abnormal morphology of the face; Distinctive facies; Dysmorphic facial features; Dysmorphic facies; Facial dysmorphism; Unusual facial appearance; Unusual facies; Distortion of face; Funny looking face\n'}


{'id': 'HP_0002000', 'url': 'http://purl.obolibrary.org/obo/HP_0002000', 'lbl': 'Short columella', 'desc': 'label: Short columella\ndefinition : Reduced distance from the anterior border of the naris to the subnasale.\nsynonyms :Columella, short; Decreased length of columella; Hypoplasia of columella\n'}


{'id': 'HP_0002002', 'url': 'http://purl.obolibrary.org/obo/HP_0002002', 'lbl': 'Deep philtrum', 'desc': 'label: Deep philtrum\ndefinition : Accentuated, prominent philtral ridges giving rise to an exaggerated groove in the midline between the nasal base and upper vermillion border.\nsynonyms :Increased depth of philtrum; Philtrum, deep; Prominent philtrum; Pronounced philtrum; Depressed philtrum\n'}


{'id': 'HP_0002003', 'url': 'http://purl.obolibrary.org/obo/HP_0002003', 'lbl': 'Large forehead', 'desc': 'label: Large forehead\ndefinition : \nsynonyms :Increased size of forehead; Increased size of frontal region of face; Large forehead; Hyperplasia of forehead; Hypertrophy of forehead\n'}


{'id': 'HP_0002006', 'url': 'http://purl.obolibrary.org/obo/HP_0002006', 'lbl': 'Facial cleft', 'desc': 'label: Facial cleft\ndefinition : A congenital malformation with a cleft (gap or opening) in the face.\nsynonyms :Cleft of the face; Facial cleft; Tessier facial cleft; Facial clefts\n'}


{'id': 'HP_0002007', 'url': 'http://purl.obolibrary.org/obo/HP_0002007', 'lbl': 'Frontal bossing', 'desc': 'label: Frontal bossing\ndefinition : Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.\nsynonyms :Frontal protruberance; Skull bossing\n'}


{'id': 'HP_0002009', 'url': 'http://purl.obolibrary.org/obo/HP_0002009', 'lbl': 'Potter facies', 'desc': 'label: Potter facies\ndefinition : A facial appearance characteristic of a fetus or neonate due to oligohydramnios experienced in the womb, comprising ocular hypertelorism, low-set ears, receding chin, and flattening of the nose.\nsynonyms :\n'}


{'id': 'HP_0002010', 'url': 'http://purl.obolibrary.org/obo/HP_0002010', 'lbl': 'Narrow maxilla', 'desc': 'label: Narrow maxilla\ndefinition : \nsynonyms :Decreased breadth of upper jaw bones; Decreased transverse dimension of maxilla; Decreased width of maxilla; Decreased width of upper jaw bones; Narrow upper jaw bones; Transverse hypoplasia of maxilla; Transverse maxillary deficiency; Transverse maxillary insufficiency\n'}


{'id': 'HP_0002011', 'url': 'http://purl.obolibrary.org/obo/HP_0002011', 'lbl': 'Morphological central nervous system abnormality', 'desc': 'label: Morphological central nervous system abnormality\ndefinition : A structural abnormality of the central nervous system.\nsynonyms :Abnormality of the central nervous system; Morphological abnormality of the CNS; Morphological abnormality of the central nervous system; Central nervous system disease\n'}


{'id': 'HP_0002012', 'url': 'http://purl.obolibrary.org/obo/HP_0002012', 'lbl': 'Abnormality of the abdominal organs', 'desc': 'label: Abnormality of the abdominal organs\ndefinition : An abnormality of the viscera of the abdomen.\nsynonyms :Abnormality of the abdominal organs; Gastrointestinal tract defects\n'}


{'id': 'HP_0002013', 'url': 'http://purl.obolibrary.org/obo/HP_0002013', 'lbl': 'Vomiting', 'desc': 'label: Vomiting\ndefinition : Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.\nsynonyms :Emesis; Throwing up; Vomiting\n'}


{'id': 'HP_0002014', 'url': 'http://purl.obolibrary.org/obo/HP_0002014', 'lbl': 'Diarrhea', 'desc': 'label: Diarrhea\ndefinition : Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day.\nsynonyms :Diarrhea; Diarrhoea; Watery stool\n'}


{'id': 'HP_0002015', 'url': 'http://purl.obolibrary.org/obo/HP_0002015', 'lbl': 'Dysphagia', 'desc': 'label: Dysphagia\ndefinition : Difficulty in swallowing.\nsynonyms :Difficulty swallowing; Poor swallowing; Swallowing difficulties; Swallowing difficulty; Deglutition disorder\n'}


{'id': 'HP_0002017', 'url': 'http://purl.obolibrary.org/obo/HP_0002017', 'lbl': 'Nausea and vomiting', 'desc': 'label: Nausea and vomiting\ndefinition : Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea.\nsynonyms :Nausea and vomiting\n'}


{'id': 'HP_0002018', 'url': 'http://purl.obolibrary.org/obo/HP_0002018', 'lbl': 'Nausea', 'desc': 'label: Nausea\ndefinition : A sensation of unease in the stomach together with an urge to vomit.\nsynonyms :Nausea\n'}


{'id': 'HP_0002019', 'url': 'http://purl.obolibrary.org/obo/HP_0002019', 'lbl': 'Constipation', 'desc': 'label: Constipation\ndefinition : Infrequent or difficult evacuation of feces.\nsynonyms :Constipation; Costiveness; Dyschezia\n'}


{'id': 'HP_0002020', 'url': 'http://purl.obolibrary.org/obo/HP_0002020', 'lbl': 'Gastroesophageal reflux', 'desc': 'label: Gastroesophageal reflux\ndefinition : A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter.\nsynonyms :Acid reflux; Acid reflux disease; GERD; Gastro-esophageal reflux; Gastro-oesophageal reflux; Gastroesophageal reflux disease; Heartburn\n'}


{'id': 'HP_0002021', 'url': 'http://purl.obolibrary.org/obo/HP_0002021', 'lbl': 'Pyloric stenosis', 'desc': 'label: Pyloric stenosis\ndefinition : Pyloric stenosis, also known as infantile hypertrophic pyloric stenosis, is an uncommon condition in infants characterized by abnormal thickening of the pylorus muscles in the stomach leading to gastric outlet obstruction. Clinically infants are well at birth. Then, at 3 to 6 weeks of age, the infants present with projectile vomiting, potentially leading to dehydration and weight loss.\nsynonyms :Infantile hypertrophic pyloric stenosis; Pylorus stenosis\n'}


{'id': 'HP_0002023', 'url': 'http://purl.obolibrary.org/obo/HP_0002023', 'lbl': 'Anal atresia', 'desc': 'label: Anal atresia\ndefinition : Congenital absence of the anus, i.e., the opening at the bottom end of the intestinal tract.\nsynonyms :Absent anus; Imperforate anus\n'}


{'id': 'HP_0002024', 'url': 'http://purl.obolibrary.org/obo/HP_0002024', 'lbl': 'Malabsorption', 'desc': 'label: Malabsorption\ndefinition : Impaired ability to absorb one or more nutrients from the intestine.\nsynonyms :Intestinal malabsorption; Malabsorption\n'}


{'id': 'HP_0002025', 'url': 'http://purl.obolibrary.org/obo/HP_0002025', 'lbl': 'Anal stenosis', 'desc': 'label: Anal stenosis\ndefinition : Abnormal narrowing of the anal opening.\nsynonyms :Narrowing of anal opening\n'}


{'id': 'HP_0002027', 'url': 'http://purl.obolibrary.org/obo/HP_0002027', 'lbl': 'Abdominal pain', 'desc': 'label: Abdominal pain\ndefinition : An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.\nsynonyms :Gastro pain; Gastrointestinal pain; Abdominal pain; Pain in stomach; Stomach pain; Abdominal discomfort; Upset stomach\n'}


{'id': 'HP_0002028', 'url': 'http://purl.obolibrary.org/obo/HP_0002028', 'lbl': 'Chronic diarrhea', 'desc': 'label: Chronic diarrhea\ndefinition : The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks.\nsynonyms :Chronic diarrhea; Chronic diarrhoea; Diarrhea, recurrent; Recurrent diarrhea; Recurrent diarrhoea\n'}


{'id': 'HP_0002031', 'url': 'http://purl.obolibrary.org/obo/HP_0002031', 'lbl': 'Abnormal esophagus morphology', 'desc': 'label: Abnormal esophagus morphology\ndefinition : A structural abnormality of the esophagus.\nsynonyms :Abnormal oesophagus morphology; Abnormality of esophagus structure; Abnormality of oesophagus structure; Anomaly of the esophagus; Anomaly of the oesophagus\n'}


{'id': 'HP_0002032', 'url': 'http://purl.obolibrary.org/obo/HP_0002032', 'lbl': 'Esophageal atresia', 'desc': 'label: Esophageal atresia\ndefinition : A developmental defect resulting in complete obliteration of the lumen of the esophagus such that the esophagus ends in a blind pouch rather than connecting to the stomach.\nsynonyms :Birth defect in which part of esophagus did not develop; Birth defect in which part of oesophagus did not develop\n'}


{'id': 'HP_0002033', 'url': 'http://purl.obolibrary.org/obo/HP_0002033', 'lbl': 'Poor suck', 'desc': 'label: Poor suck\ndefinition : An inadequate sucking reflex, resulting in the difficult of newborns to be breast-fed.\nsynonyms :Poor suck; Poor sucking; Sucking weakness\n'}


{'id': 'HP_0002034', 'url': 'http://purl.obolibrary.org/obo/HP_0002034', 'lbl': 'Abnormal rectum morphology', 'desc': 'label: Abnormal rectum morphology\ndefinition : An abnormaltiy of the rectum, the final segment of the large intestine that stores solid waste until it passes through the anus.\nsynonyms :Abnormality of the rectum; Anomaly of the rectum\n'}


{'id': 'HP_0002035', 'url': 'http://purl.obolibrary.org/obo/HP_0002035', 'lbl': 'Rectal prolapse', 'desc': 'label: Rectal prolapse\ndefinition : Protrusion of the rectal mucous membrane through the anus.\nsynonyms :Rectum protrudes through anus; Rectal prolapsed\n'}


{'id': 'HP_0002036', 'url': 'http://purl.obolibrary.org/obo/HP_0002036', 'lbl': 'Hiatus hernia', 'desc': 'label: Hiatus hernia\ndefinition : The presence of a hernia in which the upper part of the stomach, i.e., mainly the gastric cardia protrudes through the diaphragmatic esophageal hiatus.\nsynonyms :Hiatal hernia; Stomach hernia\n'}


{'id': 'HP_0002037', 'url': 'http://purl.obolibrary.org/obo/HP_0002037', 'lbl': 'Inflammation of the large intestine', 'desc': 'label: Inflammation of the large intestine\ndefinition : Inflammation, or an inflammatory state in the large intestine.\nsynonyms :Inflammation of the large intestine; Inflammatory bowel disease\n'}


{'id': 'HP_0002038', 'url': 'http://purl.obolibrary.org/obo/HP_0002038', 'lbl': 'Protein avoidance', 'desc': 'label: Protein avoidance\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002039', 'url': 'http://purl.obolibrary.org/obo/HP_0002039', 'lbl': 'Anorexia', 'desc': 'label: Anorexia\ndefinition : A lack or loss of appetite for food (as a medical condition).\nsynonyms :Anorexia\n'}


{'id': 'HP_0002040', 'url': 'http://purl.obolibrary.org/obo/HP_0002040', 'lbl': 'Esophageal varix', 'desc': 'label: Esophageal varix\ndefinition : Extreme dilation of the submucusoal veins in the lower portion of the esophagus.\nsynonyms :Enlarged vein in esophagus; Enlarged vein in oesophagus; Esophageal varices\n'}


{'id': 'HP_0002041', 'url': 'http://purl.obolibrary.org/obo/HP_0002041', 'lbl': 'Intractable diarrhea', 'desc': 'label: Intractable diarrhea\ndefinition : \nsynonyms :Intractable diarrhoea\n'}


{'id': 'HP_0002043', 'url': 'http://purl.obolibrary.org/obo/HP_0002043', 'lbl': 'Esophageal stricture', 'desc': 'label: Esophageal stricture\ndefinition : A pathological narrowing of the esophagus that is caused by the development of a ring of scar tissue that constricts the esophageal lumen.\nsynonyms :Narrowing of esophagus due to inflammation and scar tissue; Narrowing of oesophagus due to inflammation and scar tissue\n'}


{'id': 'HP_0002044', 'url': 'http://purl.obolibrary.org/obo/HP_0002044', 'lbl': 'Zollinger-Ellison syndrome', 'desc': 'label: Zollinger-Ellison syndrome\ndefinition : A condition in which there is increased production of gastrin by a gastrin-secreting tumor (usually located in the pancreas, duodenum, or abdominal lymph nodes) that stimulates the gastric mucosa to maximal activity, with consequent gastrointestinal mucosal ulceration.\nsynonyms :\n'}


{'id': 'HP_0002045', 'url': 'http://purl.obolibrary.org/obo/HP_0002045', 'lbl': 'Hypothermia', 'desc': 'label: Hypothermia\ndefinition : Reduced body temperature due to failed thermoregulation.\nsynonyms :Abnormally low body temperature; Hypothermia\n'}


{'id': 'HP_0002046', 'url': 'http://purl.obolibrary.org/obo/HP_0002046', 'lbl': 'Heat intolerance', 'desc': 'label: Heat intolerance\ndefinition : The inability to maintain a comfortable body temperature in warm or hot weather.\nsynonyms :Heat intolerance; Intolerance to heat and fevers\n'}


{'id': 'HP_0002047', 'url': 'http://purl.obolibrary.org/obo/HP_0002047', 'lbl': 'Malignant hyperthermia', 'desc': 'label: Malignant hyperthermia\ndefinition : Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C. Malignant hyperthermia may occur in response to either inhalational anesthetics such as halothane, to muscle relaxants such as succinylcholine, or to exercise.\nsynonyms :\n'}


{'id': 'HP_0002048', 'url': 'http://purl.obolibrary.org/obo/HP_0002048', 'lbl': 'Renal cortical atrophy', 'desc': 'label: Renal cortical atrophy\ndefinition : Atrophy of the cortex of the kidney.\nsynonyms :\n'}


{'id': 'HP_0002049', 'url': 'http://purl.obolibrary.org/obo/HP_0002049', 'lbl': 'Proximal renal tubular acidosis', 'desc': 'label: Proximal renal tubular acidosis\ndefinition : A type of renal tubular acidosis characterized by a failure of the proximal tubular cells to reabsorb bicarbonate, leading to urinary bicarbonate wasting and subsequent acidemia.\nsynonyms :Proximal tubular acidosis; Renal tubular acidosis, proximal; Renal tubular acidosis, type II\n'}


{'id': 'HP_0002050', 'url': 'http://purl.obolibrary.org/obo/HP_0002050', 'lbl': 'Macroorchidism, postpubertal', 'desc': 'label: Macroorchidism, postpubertal\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002054', 'url': 'http://purl.obolibrary.org/obo/HP_0002054', 'lbl': 'Heavy supraorbital ridges', 'desc': 'label: Heavy supraorbital ridges\ndefinition : \nsynonyms :Heavy brow of the face; Heavy supraorbital ridge\n'}


{'id': 'HP_0002055', 'url': 'http://purl.obolibrary.org/obo/HP_0002055', 'lbl': 'Curved linear dimple below the lower lip', 'desc': 'label: Curved linear dimple below the lower lip\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002056', 'url': 'http://purl.obolibrary.org/obo/HP_0002056', 'lbl': 'Abnormality of the glabella', 'desc': 'label: Abnormality of the glabella\ndefinition : An abnormality of the glabella.\nsynonyms :Abnormality of the area between the eyebrows; Glabellar abnormality; Deformity of the area between the eyebrows; Malformation of the area between the eyebrows\n'}


{'id': 'HP_0002057', 'url': 'http://purl.obolibrary.org/obo/HP_0002057', 'lbl': 'Prominent glabella', 'desc': 'label: Prominent glabella\ndefinition : Forward protrusion of the glabella.\nsynonyms :Convex glabella; Hyperplasia of glabella; Prominent area between the eyebrows; Protruding area between the eyebrows\n'}


{'id': 'HP_0002058', 'url': 'http://purl.obolibrary.org/obo/HP_0002058', 'lbl': 'Myopathic facies', 'desc': 'label: Myopathic facies\ndefinition : A facial appearance characteristic of myopathic conditions. The face appears expressionless with sunken cheeks, bilateral ptosis, and inability to elevate the corners of the mouth, due to muscle weakness.\nsynonyms :Myopathic face; Myopathic facial appearance\n'}


{'id': 'HP_0002059', 'url': 'http://purl.obolibrary.org/obo/HP_0002059', 'lbl': 'Cerebral atrophy', 'desc': 'label: Cerebral atrophy\ndefinition : Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum.\nsynonyms :Degeneration of cerebrum; Supratentorial atrophy\n'}


{'id': 'HP_0002060', 'url': 'http://purl.obolibrary.org/obo/HP_0002060', 'lbl': 'Abnormal cerebral morphology', 'desc': 'label: Abnormal cerebral morphology\ndefinition : Any structural abnormality of the telencephalon, which is also known as the cerebrum.\nsynonyms :Abnormality of the cerebrum; Abnormality of the telencephalon; Cerebral lesion\n'}


{'id': 'HP_0002061', 'url': 'http://purl.obolibrary.org/obo/HP_0002061', 'lbl': 'Lower limb spasticity', 'desc': 'label: Lower limb spasticity\ndefinition : Spasticity (velocity-dependent increase in tonic stretch reflexes with increased muscle tone and hyperexcitable tendon reflexes) in the muscles of the lower limbs, hips, and pelvis\nsynonyms :\n'}


{'id': 'HP_0002062', 'url': 'http://purl.obolibrary.org/obo/HP_0002062', 'lbl': 'Morphological abnormality of the pyramidal tract', 'desc': 'label: Morphological abnormality of the pyramidal tract\ndefinition : Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts.\nsynonyms :Abnormality of the pyramidal tracts; Pyramidal tract disease\n'}


{'id': 'HP_0002063', 'url': 'http://purl.obolibrary.org/obo/HP_0002063', 'lbl': 'Rigidity', 'desc': 'label: Rigidity\ndefinition : Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity.\nsynonyms :Muscle rigidity; Rigidity\n'}


{'id': 'HP_0002064', 'url': 'http://purl.obolibrary.org/obo/HP_0002064', 'lbl': 'Spastic gait', 'desc': 'label: Spastic gait\ndefinition : Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg.\nsynonyms :Spastic walk\n'}


{'id': 'HP_0002066', 'url': 'http://purl.obolibrary.org/obo/HP_0002066', 'lbl': 'Gait ataxia', 'desc': 'label: Gait ataxia\ndefinition : A type of ataxia characterized by the impairment of the ability to coordinate the movements required for normal walking. Gait ataxia is characteirzed by a wide-based staggering gait with a tendency to fall.\nsynonyms :Ataxia of gait; Ataxic gait; Inability to coordinate movements when walking\n'}


{'id': 'HP_0002067', 'url': 'http://purl.obolibrary.org/obo/HP_0002067', 'lbl': 'Bradykinesia', 'desc': 'label: Bradykinesia\ndefinition : Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement).\nsynonyms :Slow movements; Slowness of movements\n'}


{'id': 'HP_0002068', 'url': 'http://purl.obolibrary.org/obo/HP_0002068', 'lbl': 'Neuromuscular dysphagia', 'desc': 'label: Neuromuscular dysphagia\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002069', 'url': 'http://purl.obolibrary.org/obo/HP_0002069', 'lbl': 'Bilateral tonic-clonic seizure', 'desc': 'label: Bilateral tonic-clonic seizure\ndefinition : A bilateral tonic-clonic seizure is a seizure defined by a tonic (bilateral increased tone, lasting seconds to minutes) and then a clonic (bilateral sustained rhythmic jerking) phase.\nsynonyms :Bilateral convulsive seizures; Generalised convulsion; Generalised tonic-clonic seizure (without specification of onset); Generalized convulsion; Generalized tonic-clonic seizure (without specification of onset); Grand mal; Grand mal seizures; Seizures, tonic-clonic; Tonic-clonic convulsion; Tonic-clonic convulsions\n'}


{'id': 'HP_0002070', 'url': 'http://purl.obolibrary.org/obo/HP_0002070', 'lbl': 'Limb ataxia', 'desc': 'label: Limb ataxia\ndefinition : A kind of ataxia that affects movements of the extremities.\nsynonyms :Appendicular ataxia\n'}


{'id': 'HP_0002071', 'url': 'http://purl.obolibrary.org/obo/HP_0002071', 'lbl': 'Abnormality of extrapyramidal motor function', 'desc': 'label: Abnormality of extrapyramidal motor function\ndefinition : A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless).\nsynonyms :Extrapyramidal dysfunction; Extrapyramidal signs; Extrapyramidal symptoms; Extrapyramidal syndrome; Extrapyramidal tract signs\n'}


{'id': 'HP_0002072', 'url': 'http://purl.obolibrary.org/obo/HP_0002072', 'lbl': 'Chorea', 'desc': "label: Chorea\ndefinition : Chorea (Greek for 'dance') refers to widespread arrhythmic involuntary movements of a forcible, jerky and restless fashion. It is a random-appearing sequence of one or more discrete involuntary movements or movement fragments. Movements appear random because of variability in timing, duration or location. Each movement may have a distinct start and end. However, movements may be strung together and thus may appear to flow randomly from one muscle group to another. Chorea can involve the trunk, neck, face, tongue, and extremities.\nsynonyms :Choreic movements; Choreiform movements; Choreatic disease\n"}


{'id': 'HP_0002073', 'url': 'http://purl.obolibrary.org/obo/HP_0002073', 'lbl': 'Progressive cerebellar ataxia', 'desc': 'label: Progressive cerebellar ataxia\ndefinition : \nsynonyms :Cerebellar ataxia, progressive; Progressive ataxia\n'}


{'id': 'HP_0002074', 'url': 'http://purl.obolibrary.org/obo/HP_0002074', 'lbl': 'Increased neuronal autofluorescent lipopigment', 'desc': 'label: Increased neuronal autofluorescent lipopigment\ndefinition : Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the neuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient.\nsynonyms :Neuronal lipopigments\n'}


{'id': 'HP_0002075', 'url': 'http://purl.obolibrary.org/obo/HP_0002075', 'lbl': 'Dysdiadochokinesis', 'desc': 'label: Dysdiadochokinesis\ndefinition : A type of ataxia characterized by the impairment of the ability to perform rapidly alternating movements, such as pronating and supinating his or her hand on the dorsum of the other hand as rapidly as possible.\nsynonyms :Difficulty performing quick and alternating movements; Dysdiadochokinesia\n'}


{'id': 'HP_0002076', 'url': 'http://purl.obolibrary.org/obo/HP_0002076', 'lbl': 'Migraine', 'desc': 'label: Migraine\ndefinition : Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.\nsynonyms :Intermittent migraine headaches; Migraine; Migraine headache; Migraine headaches\n'}


{'id': 'HP_0002077', 'url': 'http://purl.obolibrary.org/obo/HP_0002077', 'lbl': 'Migraine with aura', 'desc': 'label: Migraine with aura\ndefinition : A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.\nsynonyms :\n'}


{'id': 'HP_0002078', 'url': 'http://purl.obolibrary.org/obo/HP_0002078', 'lbl': 'Truncal ataxia', 'desc': 'label: Truncal ataxia\ndefinition : Truncal ataxia is a sign of ataxia characterized by instability of the trunk. It usually occurs during sitting.\nsynonyms :Instability or lack of coordination of central trunk muscles; Trunk ataxia\n'}


{'id': 'HP_0002079', 'url': 'http://purl.obolibrary.org/obo/HP_0002079', 'lbl': 'Hypoplasia of the corpus callosum', 'desc': 'label: Hypoplasia of the corpus callosum\ndefinition : Underdevelopment of the corpus callosum.\nsynonyms :Corpus callosum hypoplasia; Hypoplasia of corpus callosum; Hypoplastic corpus callosum; Underdevelopment of part of brain called corpus callosum\n'}


{'id': 'HP_0002080', 'url': 'http://purl.obolibrary.org/obo/HP_0002080', 'lbl': 'Intention tremor', 'desc': "label: Intention tremor\ndefinition : A type of kinetic tremor that occurs during target directed movement is called intention tremor. That is, an oscillatory cerebellar ataxia that tends to be absent when the limbs are inactive and during the first part of voluntary movement but worsening as the movement continues and greater precision is required (e.g., in touching a target such as the patient's nose or a physician's finger).\nsynonyms :Cerebellar tremor; Terminal tremor\n"}


{'id': 'HP_0002083', 'url': 'http://purl.obolibrary.org/obo/HP_0002083', 'lbl': 'Migraine without aura', 'desc': 'label: Migraine without aura\ndefinition : Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia.\nsynonyms :\n'}


{'id': 'HP_0002084', 'url': 'http://purl.obolibrary.org/obo/HP_0002084', 'lbl': 'Encephalocele', 'desc': 'label: Encephalocele\ndefinition : A neural tube defect characterized by sac-like protrusions of the brain and the membranes that cover it through openings in the skull.\nsynonyms :Bifid skull; Cranium bifidum\n'}


{'id': 'HP_0002085', 'url': 'http://purl.obolibrary.org/obo/HP_0002085', 'lbl': 'Occipital encephalocele', 'desc': 'label: Occipital encephalocele\ndefinition : A type of encephalocele (that is, a a protrusion of part of the cranial contents including brain tissue through a congenital opening in the cranium, typically covered with skin or mucous membrane) in the occipital region of the skull. Occipital encephalocele presents as a midline swelling over the occipital bone. It is usually covered with normal full-thickness scalp.\nsynonyms :Brain tissue sticks out through back of skull; Occipital meningoencephalocele; Posterior encephalocele\n'}


{'id': 'HP_0002086', 'url': 'http://purl.obolibrary.org/obo/HP_0002086', 'lbl': 'Abnormality of the respiratory system', 'desc': 'label: Abnormality of the respiratory system\ndefinition : An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.\nsynonyms :Respiratory abnormality\n'}


{'id': 'HP_0002087', 'url': 'http://purl.obolibrary.org/obo/HP_0002087', 'lbl': 'Abnormality of the upper respiratory tract', 'desc': 'label: Abnormality of the upper respiratory tract\ndefinition : An abnormality of the upper respiratory tract.\nsynonyms :Abnormality of the upper respiratory tract; Upper respiratory tract issues\n'}


{'id': 'HP_0002088', 'url': 'http://purl.obolibrary.org/obo/HP_0002088', 'lbl': 'Abnormal lung morphology', 'desc': 'label: Abnormal lung morphology\ndefinition : Any structural anomaly of the lung.\nsynonyms :Abnormality of lung structure; Abnormality of the lungs; Abnormally shaped lung; Unusal lung shape; Lung disease\n'}


{'id': 'HP_0002089', 'url': 'http://purl.obolibrary.org/obo/HP_0002089', 'lbl': 'Pulmonary hypoplasia', 'desc': 'label: Pulmonary hypoplasia\ndefinition : \nsynonyms :Hypoplastic lung; Hypoplastic lungs; Lung hypoplasia; Poorly developed lungs; Small lung; Underdeveloped lung\n'}


{'id': 'HP_0002090', 'url': 'http://purl.obolibrary.org/obo/HP_0002090', 'lbl': 'Pneumonia', 'desc': 'label: Pneumonia\ndefinition : Inflammation of any part of the lung parenchyma.\nsynonyms :Pneumonia\n'}


{'id': 'HP_0002091', 'url': 'http://purl.obolibrary.org/obo/HP_0002091', 'lbl': 'Restrictive ventilatory defect', 'desc': 'label: Restrictive ventilatory defect\ndefinition : A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Spirometrically, a restrictive defect is defined as FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) less than 80 per cent. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus.\nsynonyms :Restrictive deficit on pulmonary function testing; Restrictive deficit on pulmonary function tests; Restrictive respiratory disease; Restrictive respiratory insufficiency; Restrictive respiratory syndrome; Spirometric restriction; Stiff lung or chest wall causing decreased lung volume; Restrictive lung disease\n'}


{'id': 'HP_0002092', 'url': 'http://purl.obolibrary.org/obo/HP_0002092', 'lbl': 'Pulmonary arterial hypertension', 'desc': 'label: Pulmonary arterial hypertension\ndefinition : Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position.\nsynonyms :Increased blood pressure in blood vessels of lungs; Pulmonary artery hypertension; Primary pulmonary hypertension\n'}


{'id': 'HP_0002093', 'url': 'http://purl.obolibrary.org/obo/HP_0002093', 'lbl': 'Respiratory insufficiency', 'desc': 'label: Respiratory insufficiency\ndefinition : \nsynonyms :Respiratory impairment; Respiratory function loss\n'}


{'id': 'HP_0002094', 'url': 'http://purl.obolibrary.org/obo/HP_0002094', 'lbl': 'Dyspnea', 'desc': 'label: Dyspnea\ndefinition : Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.\nsynonyms :Abnormal breathing; Breathing difficulty; Difficult to breathe; Difficulty breathing; Dyspnoea; Shortness of breath; Trouble breathing; Panting\n'}


{'id': 'HP_0002097', 'url': 'http://purl.obolibrary.org/obo/HP_0002097', 'lbl': 'Emphysema', 'desc': 'label: Emphysema\ndefinition : \nsynonyms :Pulmonary emphysema\n'}


{'id': 'HP_0002098', 'url': 'http://purl.obolibrary.org/obo/HP_0002098', 'lbl': 'Respiratory distress', 'desc': 'label: Respiratory distress\ndefinition : Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.\nsynonyms :Breathing difficulties; Labored breathing; Respiratory difficulties\n'}


{'id': 'HP_0002099', 'url': 'http://purl.obolibrary.org/obo/HP_0002099', 'lbl': 'Asthma', 'desc': 'label: Asthma\ndefinition : Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.\nsynonyms :Asthma; Bronchial asthma; Reactive airway disease\n'}


{'id': 'HP_0002100', 'url': 'http://purl.obolibrary.org/obo/HP_0002100', 'lbl': 'Recurrent aspiration pneumonia', 'desc': 'label: Recurrent aspiration pneumonia\ndefinition : Increased susceptibility to aspiration pneumonia, defined as pneumonia due to breathing in foreign material, as manifested by a medical history of repeated episodes of aspiration pneumonia.\nsynonyms :Recurrent pneumonia due to aspiration,\n'}


{'id': 'HP_0002101', 'url': 'http://purl.obolibrary.org/obo/HP_0002101', 'lbl': 'Abnormal lung lobation', 'desc': 'label: Abnormal lung lobation\ndefinition : A developmental defect in the formation of pulmonary lobes.\nsynonyms :Defective lung lobation; Lung segmentation defects\n'}


{'id': 'HP_0002102', 'url': 'http://purl.obolibrary.org/obo/HP_0002102', 'lbl': 'Pleuritis', 'desc': 'label: Pleuritis\ndefinition : Inflammation of the pleura.\nsynonyms :Inflammation of tissues lining lungs and chest; Pleurisy\n'}


{'id': 'HP_0002103', 'url': 'http://purl.obolibrary.org/obo/HP_0002103', 'lbl': 'Abnormal pleura morphology', 'desc': 'label: Abnormal pleura morphology\ndefinition : An abnormality of the pulmonary pleura, the thin, transparent membrane which covers the lungs and lines the inside of the chest walls.\nsynonyms :Abnormality of the pleura\n'}


{'id': 'HP_0002104', 'url': 'http://purl.obolibrary.org/obo/HP_0002104', 'lbl': 'Apnea', 'desc': 'label: Apnea\ndefinition : Lack of breathing with no movement of the respiratory muscles and no exchange of air in the lungs. This term refers to a disposition to have recurrent episodes of apnea rather than to a single event.\nsynonyms :Absence of spontaneous respiration; Apneic episodes; Apnoea\n'}


{'id': 'HP_0002105', 'url': 'http://purl.obolibrary.org/obo/HP_0002105', 'lbl': 'Hemoptysis', 'desc': 'label: Hemoptysis\ndefinition : Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs.\nsynonyms :Coughing up blood; Haemoptysis; Coughing up blood or blood-stained mucus\n'}


{'id': 'HP_0002107', 'url': 'http://purl.obolibrary.org/obo/HP_0002107', 'lbl': 'Pneumothorax', 'desc': 'label: Pneumothorax\ndefinition : Accumulation of air in the pleural cavity leading to a partially or completely collapsed lung.\nsynonyms :Collapsed lung\n'}


{'id': 'HP_0002108', 'url': 'http://purl.obolibrary.org/obo/HP_0002108', 'lbl': 'Spontaneous pneumothorax', 'desc': 'label: Spontaneous pneumothorax\ndefinition : Pneumothorax occurring without traumatic injury to the chest or lung.\nsynonyms :Spontaneous collapsed lung\n'}


{'id': 'HP_0002109', 'url': 'http://purl.obolibrary.org/obo/HP_0002109', 'lbl': 'obsolete Abnormality of the bronchi', 'desc': 'label: obsolete Abnormality of the bronchi\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002110', 'url': 'http://purl.obolibrary.org/obo/HP_0002110', 'lbl': 'Bronchiectasis', 'desc': 'label: Bronchiectasis\ndefinition : Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.\nsynonyms :Permanent enlargement of the airways of the lungs\n'}


{'id': 'HP_0002111', 'url': 'http://purl.obolibrary.org/obo/HP_0002111', 'lbl': 'obsolete Restrictive deficit on pulmonary function testing', 'desc': 'label: obsolete Restrictive deficit on pulmonary function testing\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002113', 'url': 'http://purl.obolibrary.org/obo/HP_0002113', 'lbl': 'Pulmonary infiltrates', 'desc': 'label: Pulmonary infiltrates\ndefinition : \nsynonyms :Lung infiltrates; Pulmonic infiltration\n'}


{'id': 'HP_0002118', 'url': 'http://purl.obolibrary.org/obo/HP_0002118', 'lbl': 'Abnormal cerebral ventricle morphology', 'desc': 'label: Abnormal cerebral ventricle morphology\ndefinition : Any structural abnormality of the cerebral ventricles.\nsynonyms :Abnormality of the cerebral ventricles\n'}


{'id': 'HP_0002119', 'url': 'http://purl.obolibrary.org/obo/HP_0002119', 'lbl': 'Ventriculomegaly', 'desc': 'label: Ventriculomegaly\ndefinition : An increase in size of the ventricular system of the brain.\nsynonyms :Cerebral ventricular dilatation; Dilated cerebral ventricle; Dilated cerebral ventricles; Dilated ventricles; Enlarged cerebral ventricles; Enlarged ventricles; Enlarged ventricular system; Large cerebral ventricles and cisternae; Ventricular dilatation\n'}


{'id': 'HP_0002120', 'url': 'http://purl.obolibrary.org/obo/HP_0002120', 'lbl': 'Cerebral cortical atrophy', 'desc': 'label: Cerebral cortical atrophy\ndefinition : Atrophy of the cortex of the cerebrum.\nsynonyms :Cerebral cortex atrophy; Cortical atrophy; Decrease in size of the outer layer of the brain due to loss of brain cells\n'}


{'id': 'HP_0002121', 'url': 'http://purl.obolibrary.org/obo/HP_0002121', 'lbl': 'Generalized non-motor (absence) seizure', 'desc': 'label: Generalized non-motor (absence) seizure\ndefinition : A generalized non-motor (absence) seizure is a type of a type of dialeptic seizure that is of electrographically generalized onset. It is a generalized seizure characterised by an interruption of activities, a blank stare, and usually the person will be unresponsive when spoken to. Any ictal motor phenomena are minor in comparison to these non-motor features.\nsynonyms :Absence seizure; Absence seizures; Brief seizures with staring spells; Generalised non-motor (absence) seizure; Generalised non-motor seizure; Petit mal; Petit mal seizure; Petit mal seizures\n'}


{'id': 'HP_0002123', 'url': 'http://purl.obolibrary.org/obo/HP_0002123', 'lbl': 'Generalized myoclonic seizure', 'desc': 'label: Generalized myoclonic seizure\ndefinition : A generalized myoclonic seizure is a type of generalized motor seizure characterised by bilateral, sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.\nsynonyms :Generalised epileptic myoclonus; Generalised myoclonic seizure; Generalised myoclonic seizures; Generalized epileptic myoclonus; Generalized myoclonic seizures; Myoclonus seizures; Myoclonic epilepsy, progressive\n'}


{'id': 'HP_0002126', 'url': 'http://purl.obolibrary.org/obo/HP_0002126', 'lbl': 'Polymicrogyria', 'desc': 'label: Polymicrogyria\ndefinition : Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds).\nsynonyms :More grooves in brain\n'}


{'id': 'HP_0002127', 'url': 'http://purl.obolibrary.org/obo/HP_0002127', 'lbl': 'Abnormal upper motor neuron morphology', 'desc': 'label: Abnormal upper motor neuron morphology\ndefinition : Any structural anomaly that affects the upper motor neuron.\nsynonyms :Abnormal shape of upper motor neuron\n'}


{'id': 'HP_0002131', 'url': 'http://purl.obolibrary.org/obo/HP_0002131', 'lbl': 'Episodic ataxia', 'desc': 'label: Episodic ataxia\ndefinition : Periodic spells of incoordination and imbalance, that is, episodes of ataxia typically lasting from 10 minutes to several hours or days.\nsynonyms :Intermittent cerebellar ataxia; Paroxysmal ataxia\n'}


{'id': 'HP_0002132', 'url': 'http://purl.obolibrary.org/obo/HP_0002132', 'lbl': 'Porencephalic cyst', 'desc': 'label: Porencephalic cyst\ndefinition : A cavity within the cerebral hemisphere, filled with cerebrospinal fluid, that communicates directly with the ventricular system.\nsynonyms :Cavity within brain\n'}


{'id': 'HP_0002133', 'url': 'http://purl.obolibrary.org/obo/HP_0002133', 'lbl': 'Status epilepticus', 'desc': 'label: Status epilepticus\ndefinition : Status epilepticus is a type of prolonged seizure resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms which lead to abnormally prolonged seizures (after time point t1). It is a condition that can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures.\nsynonyms :Prolonged seizure; Repeated seizure without recovery; Repeated seizures without recovery between them\n'}


{'id': 'HP_0002134', 'url': 'http://purl.obolibrary.org/obo/HP_0002134', 'lbl': 'Abnormal basal ganglia morphology', 'desc': 'label: Abnormal basal ganglia morphology\ndefinition : Abnormality of the basal ganglia.\nsynonyms :Abnormality of the basal ganglia; Anomaly of the basal ganglia; Basal ganglia disease\n'}


{'id': 'HP_0002135', 'url': 'http://purl.obolibrary.org/obo/HP_0002135', 'lbl': 'Basal ganglia calcification', 'desc': 'label: Basal ganglia calcification\ndefinition : The presence of calcium deposition affecting one or more structures of the basal ganglia.\nsynonyms :Basal ganglia calcifications; Basal ganglion calcification; Calcification of the basal ganglia\n'}


{'id': 'HP_0002136', 'url': 'http://purl.obolibrary.org/obo/HP_0002136', 'lbl': 'Broad-based gait', 'desc': 'label: Broad-based gait\ndefinition : An abnormal gait pattern in which persons stand and walk with their feet spaced widely apart. This is often a component of cerebellar ataxia.\nsynonyms :Broad based gait; Wide based gait; Wide based walk; Wide-based gait\n'}


{'id': 'HP_0002138', 'url': 'http://purl.obolibrary.org/obo/HP_0002138', 'lbl': 'Subarachnoid hemorrhage', 'desc': 'label: Subarachnoid hemorrhage\ndefinition : Hemorrhage occurring between the arachnoid mater and the pia mater.\nsynonyms :Subarachnoid haemorrhage\n'}


{'id': 'HP_0002139', 'url': 'http://purl.obolibrary.org/obo/HP_0002139', 'lbl': 'Arrhinencephaly', 'desc': 'label: Arrhinencephaly\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002140', 'url': 'http://purl.obolibrary.org/obo/HP_0002140', 'lbl': 'Ischemic stroke', 'desc': 'label: Ischemic stroke\ndefinition : Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured.\nsynonyms :Ischaemic stroke\n'}


{'id': 'HP_0002141', 'url': 'http://purl.obolibrary.org/obo/HP_0002141', 'lbl': 'Gait imbalance', 'desc': 'label: Gait imbalance\ndefinition : \nsynonyms :Abnormality of balance; Abnormality of equilibrium; Imbalanced walk\n'}


{'id': 'HP_0002143', 'url': 'http://purl.obolibrary.org/obo/HP_0002143', 'lbl': 'Abnormal spinal cord morphology', 'desc': 'label: Abnormal spinal cord morphology\ndefinition : A structural abnormality of the spinal cord (myelon).\nsynonyms :Abnormality of the spinal cord; Spinal cord disease; Spinal cord pathology\n'}


{'id': 'HP_0002144', 'url': 'http://purl.obolibrary.org/obo/HP_0002144', 'lbl': 'Tethered cord', 'desc': 'label: Tethered cord\ndefinition : During normal embryological development, the spinal cord first occupies the entire length of the vertebral column but goes on to assume a position at the level of L1 due to differential growth of the conus medullaris and the vertebral column. The filum terminale is a slender, threadlike structure that remains after the normal regression of the distal embryonic spinal cord and attaches the spinal cord to the coccyx. A tethered cord results if there is a thickened rope-like filum terminale which anchors the cord at the level of L2 or below, potentially causing neurologic signs owing to abnormal tension on the spinal cord.\nsynonyms :Occult spinal dysraphism\n'}


{'id': 'HP_0002145', 'url': 'http://purl.obolibrary.org/obo/HP_0002145', 'lbl': 'Frontotemporal dementia', 'desc': 'label: Frontotemporal dementia\ndefinition : A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders.\nsynonyms :\n'}


{'id': 'HP_0002148', 'url': 'http://purl.obolibrary.org/obo/HP_0002148', 'lbl': 'Hypophosphatemia', 'desc': 'label: Hypophosphatemia\ndefinition : An abnormally decreased phosphate concentration in the blood.\nsynonyms :Hypophosphataemia; Low blood phosphate level\n'}


{'id': 'HP_0002149', 'url': 'http://purl.obolibrary.org/obo/HP_0002149', 'lbl': 'Hyperuricemia', 'desc': 'label: Hyperuricemia\ndefinition : An abnormally high level of uric acid in the blood.\nsynonyms :High blood uric acid level; Hyperuricaemia\n'}


{'id': 'HP_0002150', 'url': 'http://purl.obolibrary.org/obo/HP_0002150', 'lbl': 'Hypercalciuria', 'desc': 'label: Hypercalciuria\ndefinition : \nsynonyms :Elevated urine calcium levels; Hypercalcinuria\n'}


{'id': 'HP_0002151', 'url': 'http://purl.obolibrary.org/obo/HP_0002151', 'lbl': 'Increased serum lactate', 'desc': 'label: Increased serum lactate\ndefinition : Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35).\nsynonyms :Higher than normal levels of lactate in blood; Increased blood lactate\n'}


{'id': 'HP_0002152', 'url': 'http://purl.obolibrary.org/obo/HP_0002152', 'lbl': 'Hyperproteinemia', 'desc': 'label: Hyperproteinemia\ndefinition : An increased concentration of proteins in the blood.\nsynonyms :\n'}


{'id': 'HP_0002153', 'url': 'http://purl.obolibrary.org/obo/HP_0002153', 'lbl': 'Hyperkalemia', 'desc': 'label: Hyperkalemia\ndefinition : An abnormally increased potassium concentration in the blood.\nsynonyms :Elevated serum potassium levels\n'}


{'id': 'HP_0002154', 'url': 'http://purl.obolibrary.org/obo/HP_0002154', 'lbl': 'Hyperglycinemia', 'desc': 'label: Hyperglycinemia\ndefinition : An elevated concentration of glycine in the blood.\nsynonyms :Elevated blood glycine levels; Hyperglycinaemia\n'}


{'id': 'HP_0002155', 'url': 'http://purl.obolibrary.org/obo/HP_0002155', 'lbl': 'Hypertriglyceridemia', 'desc': 'label: Hypertriglyceridemia\ndefinition : An abnormal increase in the level of triglycerides in the blood.\nsynonyms :Increased circulating Tg levels; Increased plasma Tg levels; Increased plasma triglycerides; Increased serum triglycerides; Increased triglycerides\n'}


{'id': 'HP_0002156', 'url': 'http://purl.obolibrary.org/obo/HP_0002156', 'lbl': 'Homocystinuria', 'desc': 'label: Homocystinuria\ndefinition : An increased concentration of homocystine in the urine.\nsynonyms :High urine homocystine levels\n'}


{'id': 'HP_0002157', 'url': 'http://purl.obolibrary.org/obo/HP_0002157', 'lbl': 'Azotemia', 'desc': 'label: Azotemia\ndefinition : An increased concentration of nitrogen compounds in the blood.\nsynonyms :Azotaemia\n'}


{'id': 'HP_0002159', 'url': 'http://purl.obolibrary.org/obo/HP_0002159', 'lbl': 'Heparan sulfate excretion in urine', 'desc': 'label: Heparan sulfate excretion in urine\ndefinition : An increased concentration of heparan sulfates in the urine.\nsynonyms :Heparan sulphate excretion in urine\n'}


{'id': 'HP_0002160', 'url': 'http://purl.obolibrary.org/obo/HP_0002160', 'lbl': 'Hyperhomocystinemia', 'desc': 'label: Hyperhomocystinemia\ndefinition : An increased concentration of homocystine in the blood.\nsynonyms :Elevated blood homocystine; Homocystinemia\n'}


{'id': 'HP_0002161', 'url': 'http://purl.obolibrary.org/obo/HP_0002161', 'lbl': 'Hyperlysinemia', 'desc': 'label: Hyperlysinemia\ndefinition : An increased concentration of lysine in the blood.\nsynonyms :Elevated blood lysine\n'}


{'id': 'HP_0002162', 'url': 'http://purl.obolibrary.org/obo/HP_0002162', 'lbl': 'Low posterior hairline', 'desc': 'label: Low posterior hairline\ndefinition : Hair on the neck extends more inferiorly than usual.\nsynonyms :Low hairline at back of neck; Low posterior hair line\n'}


{'id': 'HP_0002164', 'url': 'http://purl.obolibrary.org/obo/HP_0002164', 'lbl': 'Nail dysplasia', 'desc': 'label: Nail dysplasia\ndefinition : The presence of developmental dysplasia of the nail.\nsynonyms :Atypical nail growth; Dysplastic nails; Onychodysplasia\n'}


{'id': 'HP_0002165', 'url': 'http://purl.obolibrary.org/obo/HP_0002165', 'lbl': 'Pterygium of nails', 'desc': 'label: Pterygium of nails\ndefinition : Inward advance of skin over the nail plate.\nsynonyms :Nail pterygium\n'}


{'id': 'HP_0002166', 'url': 'http://purl.obolibrary.org/obo/HP_0002166', 'lbl': 'Impaired vibration sensation in the lower limbs', 'desc': 'label: Impaired vibration sensation in the lower limbs\ndefinition : A decrease in the ability to perceive vibration in the legs.\nsynonyms :Decreased lower limb vibratory sense; Decreased vibratory sense in lower limbs; Decreased vibratory sense in the lower extremities; Decreased vibratory sense in the lower limbs; Diminished vibratory sensation in the legs; Distal sensory loss, especially vibratory sense; Distal vibratory impairment of the lower limbs; Impaired vibration sensation in the lower limbs\n'}


{'id': 'HP_0002167', 'url': 'http://purl.obolibrary.org/obo/HP_0002167', 'lbl': 'Abnormality of speech or vocalization', 'desc': "label: Abnormality of speech or vocalization\ndefinition : Abnormalities in the sound of a person's speech or vocalization which are not necessarily associated with a known physical cause.\nsynonyms :\n"}


{'id': 'HP_0002168', 'url': 'http://purl.obolibrary.org/obo/HP_0002168', 'lbl': 'Scanning speech', 'desc': 'label: Scanning speech\ndefinition : An abnormal pattern of speech in which the words are as if measured or scanned; there is a pause after every syllable, and the syllables themselves are pronounced slowly.\nsynonyms :Explosive speech\n'}


{'id': 'HP_0002169', 'url': 'http://purl.obolibrary.org/obo/HP_0002169', 'lbl': 'Clonus', 'desc': 'label: Clonus\ndefinition : A series of rhythmic and involuntary muscle contractions (at a frequency of about 5 to 7 Hz) that occur in response to an abruptly applied and sustained stretch.\nsynonyms :Involuntary rhythmic muscular contractions and relaxations\n'}


{'id': 'HP_0002170', 'url': 'http://purl.obolibrary.org/obo/HP_0002170', 'lbl': 'Intracranial hemorrhage', 'desc': 'label: Intracranial hemorrhage\ndefinition : Hemorrhage occurring within the skull.\nsynonyms :Bleeding within the skull; Intracranial haemorrhage\n'}


{'id': 'HP_0002171', 'url': 'http://purl.obolibrary.org/obo/HP_0002171', 'lbl': 'Gliosis', 'desc': 'label: Gliosis\ndefinition : Gliosis is the focal proliferation of glial cells in the central nervous system.\nsynonyms :Cerebral gliosis; Excess astrocytes in brain\n'}


{'id': 'HP_0002172', 'url': 'http://purl.obolibrary.org/obo/HP_0002172', 'lbl': 'Postural instability', 'desc': 'label: Postural instability\ndefinition : A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps.\nsynonyms :Balance impairment; Abnormal retropulsion test; Imbalance\n'}


{'id': 'HP_0002173', 'url': 'http://purl.obolibrary.org/obo/HP_0002173', 'lbl': 'Hypoglycemic seizures', 'desc': 'label: Hypoglycemic seizures\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002174', 'url': 'http://purl.obolibrary.org/obo/HP_0002174', 'lbl': 'Postural tremor', 'desc': 'label: Postural tremor\ndefinition : A type of tremors that is triggered by holding a limb in a fixed position.\nsynonyms :Tremor, postural\n'}


{'id': 'HP_0002176', 'url': 'http://purl.obolibrary.org/obo/HP_0002176', 'lbl': 'Spinal cord compression', 'desc': 'label: Spinal cord compression\ndefinition : External mechanical compression of the spinal cord.\nsynonyms :Pressure on spinal cord\n'}


{'id': 'HP_0002179', 'url': 'http://purl.obolibrary.org/obo/HP_0002179', 'lbl': 'Opisthotonus', 'desc': 'label: Opisthotonus\ndefinition : \nsynonyms :Opisthotonos\n'}


{'id': 'HP_0002180', 'url': 'http://purl.obolibrary.org/obo/HP_0002180', 'lbl': 'Neurodegeneration', 'desc': 'label: Neurodegeneration\ndefinition : Progressive loss of neural cells and tissue.\nsynonyms :Ongoing loss of nerve cells; Neuro-degenerative disease; Neurodegenerative disease; Progressive neurodegenerative disorder\n'}


{'id': 'HP_0002181', 'url': 'http://purl.obolibrary.org/obo/HP_0002181', 'lbl': 'Cerebral edema', 'desc': 'label: Cerebral edema\ndefinition : Abnormal accumulation of fluid in the brain.\nsynonyms :Brain swelling; Brain edema; Brain oedema; Cerebral oedema; Swelling of brain\n'}


{'id': 'HP_0002183', 'url': 'http://purl.obolibrary.org/obo/HP_0002183', 'lbl': 'Phonophobia', 'desc': 'label: Phonophobia\ndefinition : An abnormally heightened sensitivity to loud sounds.\nsynonyms :Fear of loud sounds\n'}


{'id': 'HP_0002185', 'url': 'http://purl.obolibrary.org/obo/HP_0002185', 'lbl': 'Neurofibrillary tangles', 'desc': 'label: Neurofibrillary tangles\ndefinition : Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form.\nsynonyms :Neurofibrillary tangles composed of disordered microtubules in neurons; Paired helical filaments\n'}


{'id': 'HP_0002186', 'url': 'http://purl.obolibrary.org/obo/HP_0002186', 'lbl': 'Apraxia', 'desc': 'label: Apraxia\ndefinition : A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements.\nsynonyms :Apraxias\n'}


{'id': 'HP_0002187', 'url': 'http://purl.obolibrary.org/obo/HP_0002187', 'lbl': 'Intellectual disability, profound', 'desc': 'label: Intellectual disability, profound\ndefinition : Profound mental retardation is defined as an intelligence quotient (IQ) below 20.\nsynonyms :IQ less than 20; Mental retardation, profound; Profound mental retardation\n'}


{'id': 'HP_0002188', 'url': 'http://purl.obolibrary.org/obo/HP_0002188', 'lbl': 'Delayed CNS myelination', 'desc': 'label: Delayed CNS myelination\ndefinition : Delayed myelination in the central nervous system.\nsynonyms :Delay in central nervous system myelination\n'}


{'id': 'HP_0002189', 'url': 'http://purl.obolibrary.org/obo/HP_0002189', 'lbl': 'obsolete Excessive daytime sleepiness', 'desc': 'label: obsolete Excessive daytime sleepiness\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002190', 'url': 'http://purl.obolibrary.org/obo/HP_0002190', 'lbl': 'Choroid plexus cyst', 'desc': 'label: Choroid plexus cyst\ndefinition : A cyst occurring within the choroid plexus within a cerebral ventricle.\nsynonyms :\n'}


{'id': 'HP_0002191', 'url': 'http://purl.obolibrary.org/obo/HP_0002191', 'lbl': 'Progressive spasticity', 'desc': 'label: Progressive spasticity\ndefinition : Spasticity that increases in degree with time.\nsynonyms :Spasticity, progressive\n'}


{'id': 'HP_0002193', 'url': 'http://purl.obolibrary.org/obo/HP_0002193', 'lbl': 'Pseudobulbar behavioral symptoms', 'desc': 'label: Pseudobulbar behavioral symptoms\ndefinition : Individuals with Pseudobulbar signs often also demonstrate abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc.\nsynonyms :Pseudobulbar behavioural symptoms\n'}


{'id': 'HP_0002194', 'url': 'http://purl.obolibrary.org/obo/HP_0002194', 'lbl': 'Delayed gross motor development', 'desc': 'label: Delayed gross motor development\ndefinition : A type of motor delay characterized by a delay in acquiring the ability to control the large muscles of the body for walking, running, sitting, and crawling.\nsynonyms :Delayed gross motor skills; Delayed motor skills; Developmental delay, gross motor; Gross motor delay; Limited gross motor development\n'}


{'id': 'HP_0002195', 'url': 'http://purl.obolibrary.org/obo/HP_0002195', 'lbl': 'Dysgenesis of the cerebellar vermis', 'desc': 'label: Dysgenesis of the cerebellar vermis\ndefinition : Defective development of the vermis of cerebellum.\nsynonyms :\n'}


{'id': 'HP_0002196', 'url': 'http://purl.obolibrary.org/obo/HP_0002196', 'lbl': 'Myelopathy', 'desc': 'label: Myelopathy\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002197', 'url': 'http://purl.obolibrary.org/obo/HP_0002197', 'lbl': 'Generalized-onset seizure', 'desc': 'label: Generalized-onset seizure\ndefinition : A generalized-onset seizure is a type of seizure originating at some point within, and rapidly engaging, bilaterally distributed networks. The networks may include cortical and subcortical structures but not necessarily the entire cortex.\nsynonyms :Generalised onset seizure; Generalised seizures; Generalised-onset seizure; Generalized onset seizure; Generalized seizures; Generalized-onset seizures; Primary generalised seizure; Primary generalized seizure\n'}


{'id': 'HP_0002198', 'url': 'http://purl.obolibrary.org/obo/HP_0002198', 'lbl': 'Dilated fourth ventricle', 'desc': 'label: Dilated fourth ventricle\ndefinition : An abnormal dilatation of the fourth cerebral ventricle.\nsynonyms :Enlarged fourth ventricle\n'}


{'id': 'HP_0002199', 'url': 'http://purl.obolibrary.org/obo/HP_0002199', 'lbl': 'Hypocalcemic seizures', 'desc': 'label: Hypocalcemic seizures\ndefinition : \nsynonyms :Low calcium seizures; Seizures due to hypocalcemia\n'}


{'id': 'HP_0002200', 'url': 'http://purl.obolibrary.org/obo/HP_0002200', 'lbl': 'Pseudobulbar signs', 'desc': 'label: Pseudobulbar signs\ndefinition : Pseudobulbar signs result from injury to an upper motor neuron lesion to the corticobulbar pathways in the pyramidal tract. Patients have difficulty chewing, swallowing and demonstrate slurred speech (often initial presentation) as well as abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc.\nsynonyms :Pseudobulbar symptoms\n'}


{'id': 'HP_0002202', 'url': 'http://purl.obolibrary.org/obo/HP_0002202', 'lbl': 'Pleural effusion', 'desc': 'label: Pleural effusion\ndefinition : The presence of an excessive amount of fluid in the pleural cavity.\nsynonyms :Fluid around lungs\n'}


{'id': 'HP_0002203', 'url': 'http://purl.obolibrary.org/obo/HP_0002203', 'lbl': 'Respiratory paralysis', 'desc': 'label: Respiratory paralysis\ndefinition : Inability to move the muscles of respiration.\nsynonyms :\n'}


{'id': 'HP_0002204', 'url': 'http://purl.obolibrary.org/obo/HP_0002204', 'lbl': 'Pulmonary embolism', 'desc': 'label: Pulmonary embolism\ndefinition : An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery.\nsynonyms :Blood clot in artery of lung\n'}


{'id': 'HP_0002205', 'url': 'http://purl.obolibrary.org/obo/HP_0002205', 'lbl': 'Recurrent respiratory infections', 'desc': 'label: Recurrent respiratory infections\ndefinition : An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.\nsynonyms :Frequent respiratory infections; Multiple respiratory infections; Recurrent respiratory infections; Susceptibility to respiratory infections; respiratory infections, recurrent\n'}


{'id': 'HP_0002206', 'url': 'http://purl.obolibrary.org/obo/HP_0002206', 'lbl': 'Pulmonary fibrosis', 'desc': 'label: Pulmonary fibrosis\ndefinition : Replacement of normal lung tissues by fibroblasts and collagen.\nsynonyms :\n'}


{'id': 'HP_0002207', 'url': 'http://purl.obolibrary.org/obo/HP_0002207', 'lbl': 'Diffuse reticular or finely nodular infiltrations', 'desc': 'label: Diffuse reticular or finely nodular infiltrations\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002208', 'url': 'http://purl.obolibrary.org/obo/HP_0002208', 'lbl': 'Coarse hair', 'desc': 'label: Coarse hair\ndefinition : Hair shafts are rough in texture.\nsynonyms :Rough hair texture; Coarse hair; Coarse hair texture\n'}


{'id': 'HP_0002209', 'url': 'http://purl.obolibrary.org/obo/HP_0002209', 'lbl': 'Sparse scalp hair', 'desc': 'label: Sparse scalp hair\ndefinition : Decreased number of hairs per unit area of skin of the scalp.\nsynonyms :Decreased number of scalp follicles; Hypotrichosis on scalp; Reduced amount of scalp hair; Reduced/lack of hair on scalp; Reduction in the number of scalp follicles; Scalp hypotrichosis; Sparse scalp hair; Thinning scalp hair; Thin scalp hair\n'}


{'id': 'HP_0002211', 'url': 'http://purl.obolibrary.org/obo/HP_0002211', 'lbl': 'White forelock', 'desc': 'label: White forelock\ndefinition : A triangular depigmented region of white hairs located in the anterior midline of the scalp.\nsynonyms :Poliosis of anterior hair; Poliosis of forelock hair; White part of hair above forehead\n'}


{'id': 'HP_0002212', 'url': 'http://purl.obolibrary.org/obo/HP_0002212', 'lbl': 'Curly hair', 'desc': 'label: Curly hair\ndefinition : \nsynonyms :Curly hair\n'}


{'id': 'HP_0002213', 'url': 'http://purl.obolibrary.org/obo/HP_0002213', 'lbl': 'Fine hair', 'desc': 'label: Fine hair\ndefinition : Hair that is fine or thin to the touch.\nsynonyms :Fine hair; Fine hair shaft; Fine hair texture; Thin hair; Thin hair shaft; Thin hair texture; Thinned hair\n'}


{'id': 'HP_0002215', 'url': 'http://purl.obolibrary.org/obo/HP_0002215', 'lbl': 'Sparse axillary hair', 'desc': 'label: Sparse axillary hair\ndefinition : Reduced number or density of axillary hair.\nsynonyms :Sparse axillary and pubic hair; Sparse scalp, axillary, and pubic hair; Limited armpit hair; Little underarm hair; sparse to absent axillary hair\n'}


{'id': 'HP_0002216', 'url': 'http://purl.obolibrary.org/obo/HP_0002216', 'lbl': 'Premature graying of hair', 'desc': 'label: Premature graying of hair\ndefinition : Development of gray hair at a younger than normal age.\nsynonyms :Early graying; Early greying; Premature graying; Premature graying of hair; Premature greying; Premature greying of hair; Premature hair graying; Premature hair greying; Premature graying of the hair; Premature greying of the hair\n'}


{'id': 'HP_0002217', 'url': 'http://purl.obolibrary.org/obo/HP_0002217', 'lbl': 'Slow-growing hair', 'desc': 'label: Slow-growing hair\ndefinition : Hair whose growth is slower than normal.\nsynonyms :Slow growing hair; Slow rate of hair growth; Slow speed of hair growth; Slow-growing hair\n'}


{'id': 'HP_0002218', 'url': 'http://purl.obolibrary.org/obo/HP_0002218', 'lbl': 'Silver-gray hair', 'desc': 'label: Silver-gray hair\ndefinition : Hypopigmented hair that appears silver-gray.\nsynonyms :Silver-gray hair; Silver-gray hair color; Silver-gray hair colour; Silvery-gray hair\n'}


{'id': 'HP_0002219', 'url': 'http://purl.obolibrary.org/obo/HP_0002219', 'lbl': 'Facial hypertrichosis', 'desc': 'label: Facial hypertrichosis\ndefinition : Excessive, increased hair growth located in the facial region.\nsynonyms :Increased facial hair growth\n'}


{'id': 'HP_0002220', 'url': 'http://purl.obolibrary.org/obo/HP_0002220', 'lbl': 'Melanin pigment aggregation in hair shafts', 'desc': 'label: Melanin pigment aggregation in hair shafts\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002221', 'url': 'http://purl.obolibrary.org/obo/HP_0002221', 'lbl': 'Absent axillary hair', 'desc': 'label: Absent axillary hair\ndefinition : Absence of axillary hair.\nsynonyms :\n'}


{'id': 'HP_0002223', 'url': 'http://purl.obolibrary.org/obo/HP_0002223', 'lbl': 'Absent eyebrow', 'desc': 'label: Absent eyebrow\ndefinition : Absence of the eyebrow.\nsynonyms :Absent eyebrow; Absent eyebrows; Failure of development of eyebrows; Agenesis of eyebrows; Aplasia of eyebrows; Loss of eyebrows; Missing eyebrows\n'}


{'id': 'HP_0002224', 'url': 'http://purl.obolibrary.org/obo/HP_0002224', 'lbl': 'Woolly hair', 'desc': 'label: Woolly hair\ndefinition : The term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter.\nsynonyms :Nappy hair texture; Kinked hair; Wooly hair; Afro-textured hair; Kinky hair texture\n'}


{'id': 'HP_0002225', 'url': 'http://purl.obolibrary.org/obo/HP_0002225', 'lbl': 'Sparse pubic hair', 'desc': 'label: Sparse pubic hair\ndefinition : Reduced number or density of pubic hair.\nsynonyms :Decreased sexual hair; Sparse pubic hair; sparse to absent pubic hair\n'}


{'id': 'HP_0002226', 'url': 'http://purl.obolibrary.org/obo/HP_0002226', 'lbl': 'White eyebrow', 'desc': 'label: White eyebrow\ndefinition : White color (lack of pigmentation) of the eyebrow.\nsynonyms :Depigmented eyebrow; Hypopigmented eyebrow; Pale eyebrow; White eyebrow; Grey eyebrow; Blonde eyebrow\n'}


{'id': 'HP_0002227', 'url': 'http://purl.obolibrary.org/obo/HP_0002227', 'lbl': 'White eyelashes', 'desc': 'label: White eyelashes\ndefinition : White color (lack of pigmentation) of the eyelashes.\nsynonyms :Blonde eyelashes; Depigmented eyelashes; Pale eyelashes; White eyelashes; Grey eyelashes\n'}


{'id': 'HP_0002229', 'url': 'http://purl.obolibrary.org/obo/HP_0002229', 'lbl': 'obsolete Alopecia areata', 'desc': 'label: obsolete Alopecia areata\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002230', 'url': 'http://purl.obolibrary.org/obo/HP_0002230', 'lbl': 'Generalized hirsutism', 'desc': 'label: Generalized hirsutism\ndefinition : Abnormally increased hair growth over much of the entire body.\nsynonyms :Excessive hairiness over body; Generalised hirsutism\n'}


{'id': 'HP_0002231', 'url': 'http://purl.obolibrary.org/obo/HP_0002231', 'lbl': 'Sparse body hair', 'desc': 'label: Sparse body hair\ndefinition : Sparseness of the body hair.\nsynonyms :Limited body hair; Little body hair; Sparse body hair; Sparse to absent body hair\n'}


{'id': 'HP_0002232', 'url': 'http://purl.obolibrary.org/obo/HP_0002232', 'lbl': 'Patchy alopecia', 'desc': 'label: Patchy alopecia\ndefinition : Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.\nsynonyms :Alopecia areata; Patchy baldness\n'}


{'id': 'HP_0002234', 'url': 'http://purl.obolibrary.org/obo/HP_0002234', 'lbl': 'Early balding', 'desc': 'label: Early balding\ndefinition : Loss of scalp hair at an earlier than normal age.\nsynonyms :Early balding\n'}


{'id': 'HP_0002235', 'url': 'http://purl.obolibrary.org/obo/HP_0002235', 'lbl': 'Pili canaliculi', 'desc': 'label: Pili canaliculi\ndefinition : A characteristic triangular, kidney- or heat-shaped diameter of hair shafts with typical longitudinal canalicular deformation as observable by scanning electron microscopy.\nsynonyms :\n'}


{'id': 'HP_0002236', 'url': 'http://purl.obolibrary.org/obo/HP_0002236', 'lbl': 'Frontal upsweep of hair', 'desc': 'label: Frontal upsweep of hair\ndefinition : Upward and/or sideward growth of anterior hair.\nsynonyms :Cowlick; Frontal Cowlick; Frontal upsweep of hair; Upswept frontal hair; Upswept frontal hair pattern; Upswept frontal hairline\n'}


{'id': 'HP_0002239', 'url': 'http://purl.obolibrary.org/obo/HP_0002239', 'lbl': 'Gastrointestinal hemorrhage', 'desc': 'label: Gastrointestinal hemorrhage\ndefinition : Hemorrhage affecting the gastrointestinal tract.\nsynonyms :GI haemorrhage; GI hemorrhage; Gastrointestinal bleeding; Gastrointestinal haemorrhage\n'}


{'id': 'HP_0002240', 'url': 'http://purl.obolibrary.org/obo/HP_0002240', 'lbl': 'Hepatomegaly', 'desc': 'label: Hepatomegaly\ndefinition : Abnormally increased size of the liver.\nsynonyms :Enlarged liver\n'}


{'id': 'HP_0002242', 'url': 'http://purl.obolibrary.org/obo/HP_0002242', 'lbl': 'Abnormal intestine morphology', 'desc': 'label: Abnormal intestine morphology\ndefinition : An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine.\nsynonyms :Abnormality of the intestine; Enteropathy\n'}


{'id': 'HP_0002243', 'url': 'http://purl.obolibrary.org/obo/HP_0002243', 'lbl': 'Protein-losing enteropathy', 'desc': 'label: Protein-losing enteropathy\ndefinition : Abnormal loss of protein from the digestive tract related to excessive leakage of plasma proteins into the lumen of the gastrointestinal tract.\nsynonyms :\n'}


{'id': 'HP_0002244', 'url': 'http://purl.obolibrary.org/obo/HP_0002244', 'lbl': 'Abnormal small intestine morphology', 'desc': 'label: Abnormal small intestine morphology\ndefinition : A structural abnormality of the small intestine.\nsynonyms :Abnormality of the small intestine\n'}


{'id': 'HP_0002245', 'url': 'http://purl.obolibrary.org/obo/HP_0002245', 'lbl': 'Meckel diverticulum', 'desc': "label: Meckel diverticulum\ndefinition : Meckel's diverticulum is a congenital diverticulum located in the distal ileum.\nsynonyms :\n"}


{'id': 'HP_0002246', 'url': 'http://purl.obolibrary.org/obo/HP_0002246', 'lbl': 'Abnormal duodenum morphology', 'desc': 'label: Abnormal duodenum morphology\ndefinition : An abnormality of the duodenum, i.e., the first section of the small intestine.\nsynonyms :Abnormality of the duodenum\n'}


{'id': 'HP_0002247', 'url': 'http://purl.obolibrary.org/obo/HP_0002247', 'lbl': 'Duodenal atresia', 'desc': 'label: Duodenal atresia\ndefinition : A developmental defect resulting in complete obliteration of the duodenal lumen, that is, an abnormal closure of the duodenum.\nsynonyms :Absence or narrowing of first part of small bowel\n'}


{'id': 'HP_0002248', 'url': 'http://purl.obolibrary.org/obo/HP_0002248', 'lbl': 'Hematemesis', 'desc': 'label: Hematemesis\ndefinition : The vomiting of blood.\nsynonyms :Vomitting blood\n'}


{'id': 'HP_0002249', 'url': 'http://purl.obolibrary.org/obo/HP_0002249', 'lbl': 'Melena', 'desc': 'label: Melena\ndefinition : The passage of blackish, tarry feces associated with gastrointestinal hemorrhage. Melena occurs if the blood remains in the colon long enough for it to be broken down by colonic bacteria. One degradation product, hematin, imbues the stool with a blackish color. Thus, melena generally occurs with bleeding from the upper gastrointestinal tract (e.g., stomach ulcers or duodenal ulcers), since the blood usually remains in the gut for a longer period of time than with lower gastrointestinal bleeding.\nsynonyms :Black faeces; Black feces\n'}


{'id': 'HP_0002250', 'url': 'http://purl.obolibrary.org/obo/HP_0002250', 'lbl': 'Abnormal large intestine morphology', 'desc': 'label: Abnormal large intestine morphology\ndefinition : Any abnormality of the large intestine.\nsynonyms :Abnormality of the large intestine\n'}


{'id': 'HP_0002251', 'url': 'http://purl.obolibrary.org/obo/HP_0002251', 'lbl': 'Aganglionic megacolon', 'desc': 'label: Aganglionic megacolon\ndefinition : An abnormality resulting from a lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) that results in bowel obstruction with enlargement of the colon.\nsynonyms :Congenital megacolon; Enlarged colon lacking nerve cells; Hirschsprung megacolon; Megacolon; Hirschsprung disease\n'}


{'id': 'HP_0002253', 'url': 'http://purl.obolibrary.org/obo/HP_0002253', 'lbl': 'Colonic diverticula', 'desc': 'label: Colonic diverticula\ndefinition : The presence of multiple diverticula of the colon.\nsynonyms :Colonic diverticulosis; Colon diverticula\n'}


{'id': 'HP_0002254', 'url': 'http://purl.obolibrary.org/obo/HP_0002254', 'lbl': 'Intermittent diarrhea', 'desc': 'label: Intermittent diarrhea\ndefinition : Repeated episodes of diarrhea separated by periods without diarrhea.\nsynonyms :Episodic diarrhea; Episodic diarrhoea; Intermittent diarrhoea\n'}


{'id': 'HP_0002256', 'url': 'http://purl.obolibrary.org/obo/HP_0002256', 'lbl': 'Small bowel diverticula', 'desc': 'label: Small bowel diverticula\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002257', 'url': 'http://purl.obolibrary.org/obo/HP_0002257', 'lbl': 'Chronic rhinitis', 'desc': 'label: Chronic rhinitis\ndefinition : Chronic inflammation of the nasal mucosa.\nsynonyms :\n'}


{'id': 'HP_0002263', 'url': 'http://purl.obolibrary.org/obo/HP_0002263', 'lbl': "Exaggerated cupid's bow", 'desc': "label: Exaggerated cupid's bow\ndefinition : More pronounced paramedian peaks and median notch of the Cupid's bow.\nsynonyms :Cupid bow upper lip; Cupid's bow, accentuated; Cupid-bow shaped upper lip; Exaggerated cupid's bow; Prominent cupid-bow of upper lip\n"}


{'id': 'HP_0002265', 'url': 'http://purl.obolibrary.org/obo/HP_0002265', 'lbl': 'Large fleshy ears', 'desc': 'label: Large fleshy ears\ndefinition : \nsynonyms :Large fleshy ears\n'}


{'id': 'HP_0002266', 'url': 'http://purl.obolibrary.org/obo/HP_0002266', 'lbl': 'Focal clonic seizure', 'desc': 'label: Focal clonic seizure\ndefinition : A focal clonic seizure is a type of focal motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive.\nsynonyms :Focal clonic seizures; Localised clonic seizure; Localized clonic seizure; Partial clonic seizure; Segmental clonic seizure\n'}


{'id': 'HP_0002267', 'url': 'http://purl.obolibrary.org/obo/HP_0002267', 'lbl': 'Exaggerated startle response', 'desc': 'label: Exaggerated startle response\ndefinition : An exaggerated startle reaction in response to a sudden unexpected visual or acoustic stimulus, or a quick movement near the face.\nsynonyms :Exaggerated acoustic startle response; Increased startle response; Hyperekplexia\n'}


{'id': 'HP_0002268', 'url': 'http://purl.obolibrary.org/obo/HP_0002268', 'lbl': 'Paroxysmal dystonia', 'desc': 'label: Paroxysmal dystonia\ndefinition : A form of dystonia characterized by episodes of dystonia (often hemidystonia or generalized) lasting from minutes to hours. There are no dystonic symptoms between episodes.\nsynonyms :Episodic dystonia\n'}


{'id': 'HP_0002269', 'url': 'http://purl.obolibrary.org/obo/HP_0002269', 'lbl': 'Abnormality of neuronal migration', 'desc': 'label: Abnormality of neuronal migration\ndefinition : An abnormality resulting from an anomaly of neuronal migration, i.e., of the process by which neurons travel from their origin to their final position in the brain.\nsynonyms :Abnormal neuronal migration; Heterotopias/abnormal migration; Migrational brain disorder; Neuronal migration disorder\n'}


{'id': 'HP_0002270', 'url': 'http://purl.obolibrary.org/obo/HP_0002270', 'lbl': 'Abnormality of the autonomic nervous system', 'desc': 'label: Abnormality of the autonomic nervous system\ndefinition : An abnormality of the autonomic nervous system.\nsynonyms :\n'}


{'id': 'HP_0002271', 'url': 'http://purl.obolibrary.org/obo/HP_0002271', 'lbl': 'obsolete Autonomic dysregulation', 'desc': 'label: obsolete Autonomic dysregulation\ndefinition : \nsynonyms :\n'}


{'id': 'HP_0002273', 'url': 'http://purl.obolibrary.org/obo/HP_0002273', 'lbl': 'Tetraparesis', 'desc': 'label: Tetraparesis\ndefinition : Weakness of all four limbs.\nsynonyms :Quadriparesis\n'}


{'id': 'HP_0002275', 'url': 'http://purl.obolibrary.org/obo/HP_0002275', 'lbl': 'Poor motor coordination', 'desc': 'label: Poor motor coordination\ndefinition : \nsynonyms :Poor motor coordination\n'}