{"docstore/data": {"38581f5e-de4f-43d9-9051-bec1e0402c29": {"__data__": {"id_": "38581f5e-de4f-43d9-9051-bec1e0402c29", "embedding": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the different dosages available for Vortioxetine and what is the active ingredient in each dosage?\n2. What is the purpose of Vortioxetine and what condition does it treat in adults?\n3. What precautions should be taken before starting to take Vortioxetine and when should this medication not be taken?", "section_summary": "This section provides information about the medication Vortioxetine, including its dosages, active ingredient, purpose, and precautions. The dosages available for Vortioxetine are 5mg, 10mg, and 20mg, with the active ingredient being Vortioxetine bromhydrate. Vortioxetine is used to treat major depression in adults. Before starting to take Vortioxetine, it is important to consider certain precautions and avoid taking the medication under certain circumstances.", "excerpt_keywords": "Vortioxetina, medicamento, prospecto, informaci\u00f3n, usuario, v\u00eda oral, comprimidos recubiertos, vigilancia adicional, tratamiento, recetado, personas, s\u00edntomas, duda, efecto adverso, m\u00e9dico, f\u00f3rmulas, bromhidrato, principio activo, antidepresivos, episodios, depresi\u00f3n mayor, adultos, tomar."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "522ac278-4954-44be-bf8c-ffca1be2f1bc", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "a3cf722ec73bc3363a8ebb48fa6ed82fc4c945311da028e424989d1b5f5b89bf"}, "3": {"node_id": "89cfbb89-9985-4563-8e0a-c30b7816aa39", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "eadf913a5dd2a8113d26a409e651e8c7cebe9cf242488f3e87399389dcd5aa5d"}}, "hash": "c496fade0ab667bf370e31b8ad9afa38de9a0950936e88bc42b15a8a6ff76a5d", "text": "Prospecto: informaci\u00f3n para el usuario \nVortioxetina \n \nV\u00eda oral  - Comprimidos recubiertos \nMedicamento con vigilancia adicional  \nLEA TODO EL PROSPECTO DETENIDAMENTE ANTES DE COMENZAR EL TRATAMIENTO  \nConserve este prospecto, ya que puede tener que volver a leerlo. Este medicamento se le ha \nrecetado a usted y no debe d\u00e1rselo a otras personas, aunque tengan los mismos s\u00edntomas. Si \ntiene alguna duda o si considera que presenta alg\u00fan efecto adverso, consulte a su m\u00e9dico.  \nF\u00d3RMULAS  \nVortioxetina 5: Cada comprimido recubierto contiene:  \nVortioxetina (como bromhidrato)  5,0 mg  \nVortioxetina 10: Cada comprimido recubierto contiene:  \nVortioxetina (como bromhidrato)  10,0 mg  \nVortioxetina 20: Cada comprimido recubierto contiene:  \nVortioxetina (como bromhidrato ) 20,0 mg  \nQU\u00c9 ES VORTIOXETINA Y PARA QU\u00c9 SE UTILIZA  \nVortioxetina contiene como principio activo a la Vortioxetina. \u00c9ste pertenece a un grupo de medicamentos llamados antidepresivos. Vortioxetina se utiliza para tratar episodios de \ndepresi\u00f3n mayor en adultos. \nQU\u00c9 NECESITA SABER ANTES DE EMPEZAR A TOMAR VORTIOXETINA  \nNo tome este medicamento si:", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "89cfbb89-9985-4563-8e0a-c30b7816aa39": {"__data__": {"id_": "89cfbb89-9985-4563-8e0a-c30b7816aa39", "embedding": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for taking Vortioxetine?\n2. What are the potential risks and side effects of taking Vortioxetine for treating major depression in adults?\n3. What are the symptoms of Serotonin Syndrome (SS) and Neuroleptic Malignant Syndrome (SNM) that may occur when taking Vortioxetine in combination with other medications?", "prev_section_summary": "This section provides information about the medication Vortioxetine, including its dosages, active ingredient, purpose, and precautions. The dosages available for Vortioxetine are 5mg, 10mg, and 20mg, with the active ingredient being Vortioxetine bromhydrate. Vortioxetine is used to treat major depression in adults. Before starting to take Vortioxetine, it is important to consider certain precautions and avoid taking the medication under certain circumstances.", "section_summary": "This section provides important information about Vortioxetine, including precautions, contraindications, and risks associated with its use for treating major depression in adults. The section mentions that Vortioxetine is an antidepressant medication and should not be taken by individuals who are allergic to Vortioxetine or any of its components, or who are taking certain other medications such as non-selective monoamine oxidase inhibitors (MAOIs) or selective MAO-A inhibitors. It also advises caution when taking Vortioxetine in combination with medications that affect serotonin metabolism, serotoninergic active substances, antipsychotics, and other dopaminergic antagonists, as this may increase the risk of serotonin syndrome (SS) or neuroleptic malignant syndrome (SNM). The symptoms of SS are not mentioned in the provided excerpt.", "excerpt_keywords": "Vortioxetina, principio activo, antidepresivos, depresi\u00f3n mayor, al\u00e9rgico, inhibidores no selectivos de la monoaminooxidasa, inhibidores selectivos de la MAO-A, precauci\u00f3n, medicamentos serotonin\u00e9rgicos, tramadol, sumatript\u00e1n, triptanos, metabolismo de la serotonina, IMAOs, antipsic\u00f3ticos, antagonistas dopamin\u00e9rgicos, S\u00edndrome Serotonin\u00e9rgico, S\u00edndrome Neurol\u00e9ptico Maligno, s\u00edntomas."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "522ac278-4954-44be-bf8c-ffca1be2f1bc", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "a3cf722ec73bc3363a8ebb48fa6ed82fc4c945311da028e424989d1b5f5b89bf"}, "2": {"node_id": "38581f5e-de4f-43d9-9051-bec1e0402c29", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "c496fade0ab667bf370e31b8ad9afa38de9a0950936e88bc42b15a8a6ff76a5d"}}, "hash": "eadf913a5dd2a8113d26a409e651e8c7cebe9cf242488f3e87399389dcd5aa5d", "text": "Vortioxetina contiene como principio activo a la Vortioxetina. \u00c9ste pertenece a un grupo de medicamentos llamados antidepresivos. Vortioxetina se utiliza para tratar episodios de \ndepresi\u00f3n mayor en adultos. \nQU\u00c9 NECESITA SABER ANTES DE EMPEZAR A TOMAR VORTIOXETINA  \nNo tome este medicamento si:  \n- Es al\u00e9rgico (hipersensible) a la Vortioxetina o a cualquiera de los dem\u00e1s componentes \nde este medicamento.  \n- Se encuentra tomando otros medicamentos conocid os como inhibidores no selectivos \nde la monoaminooxidasa (IMAOs) o inhibidores selectivos de la MAO-A.  \nTENGA PRECAUCI\u00d3N  \nConsulte a su m\u00e9dico antes de empezar a tomar este medicamento si:  \n- Est\u00e1 tomando medicamentos con principios activos serotonin\u00e9rgicos ( p. ej., tramadol, \nsumatript\u00e1n y otros triptanos), medicamentos que afectan al metabolismo de la serotonina \n(incluyendo los IMAOs), antipsic\u00f3ticos y otros antagonistas dopamin\u00e9rgicos. La toma de estos \nmedicamentos junto con Vortioxetina puede aumentar el ri esgo, que ya presenta la \nadministraci\u00f3n solo con Vortioxetina sin a\u00f1adirle otro medicamento, de S\u00edndrome \nSerotonin\u00e9rgico (SS) o S\u00edndrome Neurol\u00e9ptico Maligno (SNM). Los s\u00edntomas del SS incluyen:", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "ddf203a9-df29-440d-900f-c84c894e57a1": {"__data__": {"id_": "ddf203a9-df29-440d-900f-c84c894e57a1", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment?\n2. How should Vortioxetine be used with caution in patients with a history of seizures or unstable epilepsy?\n3. What precautions should be taken when using Vortioxetine in patients with a history of mania or hypomania?", "prev_section_summary": "This section provides important information about Vortioxetine, including precautions, contraindications, and risks associated with its use for treating major depression in adults. The section mentions that Vortioxetine is an antidepressant medication and should not be taken by individuals who are allergic to Vortioxetine or any of its components, or who are taking certain other medications such as non-selective monoamine oxidase inhibitors (MAOIs) or selective MAO-A inhibitors. It also advises caution when taking Vortioxetine in combination with medications that affect serotonin metabolism, serotoninergic active substances, antipsychotics, and other dopaminergic antagonists, as this may increase the risk of serotonin syndrome (SS) or neuroleptic malignant syndrome (SNM). The symptoms of SS are not mentioned in the provided excerpt.", "section_summary": "The key topics of this section are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment, the caution needed when using Vortioxetine in patients with a history of seizures or unstable epilepsy, and the precautions to be taken when using Vortioxetine in patients with a history of mania or hypomania. The entities mentioned include changes in consciousness, autonomic instability, neuromuscular alterations, gastrointestinal symptoms, seizures, mania, and bleeding tendencies.", "excerpt_keywords": "cambios en el nivel de conciencia, agitaci\u00f3n, alucinaciones, estados de coma, inestabilidad aut\u00f3noma, taquicardia, presi\u00f3n arterial l\u00e1bil, hipertermia, alteraciones neuromusculares, hiperreflexia, descoordinaci\u00f3n, s\u00edntomas gastrointestinales, n\u00e1useas, v\u00f3mitos, diarrea, convulsiones, man\u00eda, tendencia a sangrar, hematomas f\u00e1cilmente."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "28a5a6dc0e892de294be38c592b06599316dc5606532d71ad09b255a59b330b4"}, "3": {"node_id": "92d383e2-5a2e-43f1-a706-3568521bc0ca", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "ab44c8156fce3b4638e0fa1e3a567aa3ee3aed9a1d8ddf95560c59ba69092e23"}}, "hash": "e674c968deacc17d5cdc75f5fb553efb7b983f56c0ed3be3a1eece597b6b6e05", "text": "cambios en el nivel de conciencia (p. ej., agitaci\u00f3n, alucina ciones, estados de coma), \ninestabilidad aut\u00f3noma (p. ej., taquicardia, presi\u00f3n arterial l\u00e1bil, hipertermia), alteraciones \nneuromusculares (p. ej., hiperreflexia, descoordinaci\u00f3n) y/o s\u00edntomas gastrointestinales (p. ej., \nn\u00e1useas, v\u00f3mitos o diarrea). Si esto  sucede, debe interrumpir inmediatamente el tratamiento \ncon Vortioxetina y buscar ayuda m\u00e9dica de inmediato. \n- Ha sufrido convulsiones. Su m\u00e9dico lo tratar\u00e1 con precauci\u00f3n si tiene antecedentes de \nconvulsiones o padece trastornos convulsivos inestables/ ep ilepsia. Las convulsiones son un \nriesgo potencial de este tipo de medicamentos. El tratamiento se debe interrumpir en \ncualquier paciente que experimente convulsiones o un aumento en su frecuencia. \n- Ha padecido man\u00eda. Vortioxetina  se debe usar con precauci\u00f3n en pacientes con \nantecedentes de man\u00eda/hipoman\u00eda y se debe interrumpir su administraci\u00f3n en cualquier \npaciente que entre en fase man\u00edaca.  \n- Tiene tendencia a sangrar o a que le aparezcan hematomas f\u00e1cilmente. Se han \nnotificado equimosis, p\u00farpura u otros acontecimientos hemorr\u00e1gicos, como sangrado \ngastrointestinal o ginecol\u00f3gico con el uso de este tipo de medicamentos. Se recomienda", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "92d383e2-5a2e-43f1-a706-3568521bc0ca": {"__data__": {"id_": "92d383e2-5a2e-43f1-a706-3568521bc0ca", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken for patients with a tendency to bleed easily when using Vortioxetine for treating major depression in adults?\n2. What should be considered for patients with low sodium levels in their blood when using Vortioxetine?\n3. What are the contraindications for using Vortioxetine in patients who are 65 years or older?", "prev_section_summary": "The key topics of this section are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment, the caution needed when using Vortioxetine in patients with a history of seizures or unstable epilepsy, and the precautions to be taken when using Vortioxetine in patients with a history of mania or hypomania. The entities mentioned include changes in consciousness, autonomic instability, neuromuscular alterations, gastrointestinal symptoms, seizures, mania, and bleeding tendencies.", "section_summary": "The key topics of this section are precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. The section mentions precautions for patients who have a tendency to bleed easily, patients with low sodium levels in their blood, patients who are 65 years or older, and patients with severe kidney or liver disease. The section also mentions the risk of manic episodes in patients who are prone to them.", "excerpt_keywords": "paciente, fase man\u00edaca, sangrado, hematomas, equimosis, p\u00farpura, acontecimientos hemorr\u00e1gicos, sangrado gastrointestinal, sangrado ginecol\u00f3gico, anticoagulantes, funci\u00f3n plaquetaria, antipsic\u00f3ticos at\u00edpicos, fenotiazinas, antidepresivos tric\u00edclicos, antiinflamatorios no esteroideos, \u00e1cido acetilsalic\u00edlico, niveles bajos de sodio, hiponatremia, edad avanzada, cirrosis hep\u00e1tica, enfermedad renal grave, enfermedad hep\u00e1tica grave, cirrosis, depresi\u00f3n, trastorno de ansiedad."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "28a5a6dc0e892de294be38c592b06599316dc5606532d71ad09b255a59b330b4"}, "2": {"node_id": "ddf203a9-df29-440d-900f-c84c894e57a1", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "e674c968deacc17d5cdc75f5fb553efb7b983f56c0ed3be3a1eece597b6b6e05"}, "3": {"node_id": "4be18c04-0d07-4a88-bc0c-339e92743fbd", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "de9a4071a5477e335fc1bed3228827b59230f9d012bffaaaec577e39e30498e3"}}, "hash": "ab44c8156fce3b4638e0fa1e3a567aa3ee3aed9a1d8ddf95560c59ba69092e23", "text": "paciente que entre en fase man\u00edaca.  \n- Tiene tendencia a sangrar o a que le aparezcan hematomas f\u00e1cilmente. Se han \nnotificado equimosis, p\u00farpura u otros acontecimientos hemorr\u00e1gicos, como sangrado \ngastrointestinal o ginecol\u00f3gico con el uso de este tipo de medicamentos. Se recomienda \nprecauci\u00f3n en pacientes tratados con anticoagulantes y/o medicamentos que se sabe que \nafectan a la  funci\u00f3n plaquetaria (p. ej., antipsic\u00f3ticos at\u00edpicos y fenotiazinas, la mayor\u00eda de los \nantidepresivos tric\u00edclicos, antiinflamatorios no esteroideos (AINE) y \u00e1cido acetilsalic\u00edlico (AAS)).  \n- Tiene niveles bajos de sodio en sangre. Se debe tener precauci\u00f3n en pacientes de \nriesgo, como pacientes de edad avanzada, pacientes con cirrosis hep\u00e1tica o pacientes tratados \nde manera simult\u00e1nea con medicamentos que se sabe causan hiponatremia. En pacientes con \nhiponatremia sintom\u00e1tica se debe considerar la interrupci\u00f3 n del tratamiento con Vortioxetina \ne instaurar una intervenci\u00f3n m\u00e9dica adecuada.  \n- Es una persona de 65 a\u00f1os o m\u00e1s.  \n- Padece una enfermedad renal grave.  \nPadece una enfermedad hep\u00e1tica grave, o una enfermedad hep\u00e1tica llamada cirrosis.  \nSi usted se encuentra  deprimido y/o sufre un trastorno de ansiedad, puede en algunas", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "4be18c04-0d07-4a88-bc0c-339e92743fbd": {"__data__": {"id_": "4be18c04-0d07-4a88-bc0c-339e92743fbd", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Vortioxetine in the treatment of major depression in adults?\n2. What are the potential risks and side effects of taking Vortioxetine for the first time?\n3. How can individuals who are depressed or have an anxiety disorder seek help and support while taking Vortioxetine?", "prev_section_summary": "The key topics of this section are precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. The section mentions precautions for patients who have a tendency to bleed easily, patients with low sodium levels in their blood, patients who are 65 years or older, and patients with severe kidney or liver disease. The section also mentions the risk of manic episodes in patients who are prone to them.", "section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for the treatment of major depression in adults. The section mentions that Vortioxetine should not be used in certain situations, such as in individuals with severe kidney or liver disease. It also highlights the potential risk of increased thoughts of self-harm or suicide when taking Vortioxetine for the first time, especially in individuals who have previously experienced such thoughts or are young adults. The section emphasizes the importance of seeking help and support from a doctor or hospital if experiencing these thoughts.", "excerpt_keywords": "intervenci\u00f3n m\u00e9dica, persona mayor, enfermedad renal, enfermedad hep\u00e1tica, cirrosis, depresi\u00f3n, trastorno de ansiedad, pensamientos suicidas, Vortioxetina, efectos secundarios, medicamentos, dos semanas, adulto joven, pariente, amigo cercano, cambios de actitud"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "28a5a6dc0e892de294be38c592b06599316dc5606532d71ad09b255a59b330b4"}, "2": {"node_id": "92d383e2-5a2e-43f1-a706-3568521bc0ca", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "ab44c8156fce3b4638e0fa1e3a567aa3ee3aed9a1d8ddf95560c59ba69092e23"}, "3": {"node_id": "b913cbf2-eb53-4ead-bf7e-950de6c142da", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "e2e94726c2436696708d456be65a65c3e7b0be84a02babcab96c2f2c5a8a70d3"}}, "hash": "de9a4071a5477e335fc1bed3228827b59230f9d012bffaaaec577e39e30498e3", "text": "e instaurar una intervenci\u00f3n m\u00e9dica adecuada.  \n- Es una persona de 65 a\u00f1os o m\u00e1s.  \n- Padece una enfermedad renal grave.  \nPadece una enfermedad hep\u00e1tica grave, o una enfermedad hep\u00e1tica llamada cirrosis.  \nSi usted se encuentra  deprimido y/o sufre un trastorno de ansiedad, puede en algunas \nocasiones tener pensamientos en los que se haga da\u00f1o o se quite la vida. \u00c9stos pueden ir \naumentando al tomar Vortioxetina por primera vez, puesto que todos estos medicamentos \nrequieren un tiem po para empezar a hacer efecto, generalmente alrededor de unas dos \nsemanas, aunque en algunos casos podr\u00eda ser a\u00fan mayor. Usted ser\u00eda m\u00e1s propenso a tener este tipo de pensamientos: si usted previamente ha tenido pensamientos en los que se quita la \nvida o se hace da\u00f1o, o si usted es un adulto joven. Si en cualquier momento usted tiene \npensamientos en los que se hace da\u00f1o o se quita la vida, contacte con su m\u00e9dico o dir\u00edjase \ndirectamente a un hospital. Puede ser de ayuda para usted decirle a un pariente o un  amigo \ncercano que usted est\u00e1 deprimido o que tiene un trastorno de ansiedad y pedirle que lea este prospecto. Puede preguntarles si piensan que su depresi\u00f3n o trastorno de ansiedad ha \nempeorado, o si est\u00e1n preocupados por los cambios en su actitud.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "b913cbf2-eb53-4ead-bf7e-950de6c142da": {"__data__": {"id_": "b913cbf2-eb53-4ead-bf7e-950de6c142da", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions and contraindications should be considered when using Vortioxetine for treating major depression in adults?\n2. Why is Vortioxetine not recommended for children and adolescents under 18 years old?\n3. What information is provided regarding the use of Vortioxetine during pregnancy and breastfeeding?", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for the treatment of major depression in adults. The section mentions that Vortioxetine should not be used in certain situations, such as in individuals with severe kidney or liver disease. It also highlights the potential risk of increased thoughts of self-harm or suicide when taking Vortioxetine for the first time, especially in individuals who have previously experienced such thoughts or are young adults. The section emphasizes the importance of seeking help and support from a doctor or hospital if experiencing these thoughts.", "section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. It also mentions that Vortioxetine is not recommended for children and adolescents under 18 years old due to a lack of information in this age group. Additionally, it provides information about the use of Vortioxetine during pregnancy and breastfeeding.", "excerpt_keywords": "hospital, depresi\u00f3n, trastorno de ansiedad, prospecto, pariente, amigo cercano, empeorado, cambios en la actitud, ni\u00f1os, adolescentes, vortioxetina, falta de informaci\u00f3n, embarazo, lactancia"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "28a5a6dc0e892de294be38c592b06599316dc5606532d71ad09b255a59b330b4"}, "2": {"node_id": "4be18c04-0d07-4a88-bc0c-339e92743fbd", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "de9a4071a5477e335fc1bed3228827b59230f9d012bffaaaec577e39e30498e3"}}, "hash": "e2e94726c2436696708d456be65a65c3e7b0be84a02babcab96c2f2c5a8a70d3", "text": "directamente a un hospital. Puede ser de ayuda para usted decirle a un pariente o un  amigo \ncercano que usted est\u00e1 deprimido o que tiene un trastorno de ansiedad y pedirle que lea este prospecto. Puede preguntarles si piensan que su depresi\u00f3n o trastorno de ansiedad ha \nempeorado, o si est\u00e1n preocupados por los cambios en su actitud.  \nNi\u00f1os y adolescentes: Vortioxetina no est\u00e1 recomendado en ni\u00f1os y adolescentes menores de \n18 a\u00f1os, debido a la falta de informaci\u00f3n en este grupo de edad.  \nEMBARAZO Y LACTANCIA", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "260e388b-8c94-4b17-b39e-5b122bbe644f": {"__data__": {"id_": "260e388b-8c94-4b17-b39e-5b122bbe644f", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and side effects of using Vortioxetine during pregnancy?\n2. What symptoms may be observed in a newborn if the mother takes Vortioxetine during the last 3 months of pregnancy?\n3. What should a pregnant woman do if her baby exhibits any of the mentioned symptoms after birth?", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. It also mentions that Vortioxetine is not recommended for children and adolescents under 18 years old due to a lack of information in this age group. Additionally, it provides information about the use of Vortioxetine during pregnancy and breastfeeding.", "section_summary": "The key topics of this section are the potential risks and side effects of using Vortioxetine during pregnancy. It mentions that Vortioxetine should not be used during pregnancy unless absolutely necessary, and if the benefits outweigh the possible risks to the fetus. It also states that if Vortioxetine is taken during the last 3 months of pregnancy, certain effects may be observed in the newborn, such as breathing problems, blue skin, seizures, and difficulty feeding. The section advises pregnant women to contact their doctor immediately if their baby exhibits any of these symptoms after birth. The key entities mentioned in this section are Vortioxetine, pregnancy, newborn, and the potential symptoms in the baby.", "excerpt_keywords": "embarazo, lactancia, m\u00e9dico, vortioxetina, riesgo, feto, reci\u00e9n nacido, problemas respiratorios, piel azulada, convulsiones, dificultad de alimentaci\u00f3n, v\u00f3mitos, az\u00facar bajo en sangre, m\u00fasculos r\u00edgidos, reflejos intensos, temblor, irritabilidad, letargia, somnolencia, dificultades para dormir, hipertensi\u00f3n."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "50e1d3a1c12cb22d3d1c47d1c0cf4a4726d4bf13773f87da8ebc4ed27c0f213b"}, "3": {"node_id": "ea7cff7b-7b84-49ce-8056-88d34c67e2ea", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "cee9353471cf98ec1b1e59fcb4d9a29e77a8c7116922aa51e4eeba6f40a6b633"}}, "hash": "0b3af772ddf2bddae91c03cfaf8d8e83a7bb158ac426ae11832faabb14f11d50", "text": "Si est\u00e1 embarazada o en periodo de lactancia, cree que podr\u00eda estar embarazada o tiene  \nintenci\u00f3n de quedarse embarazada, consulte a su m\u00e9dico antes de utilizar este medicamento. \nEmbarazo: Vortioxetina no se debe utilizar durante el embarazo a menos que su m\u00e9dico lo \nconsidere absolutamente necesario, y si los beneficios previstos superan el posible riesgo para \nel feto. Si toma este tipo de medicamentos durante los \u00faltimos 3 meses del embarazo, debe \nsaber que se pueden observar los siguientes efectos en el reci\u00e9n nacido: problemas para \nrespirar, piel azulada, apnea, convulsiones, cambios de la temperatura corporal, dificultad de \nalimentaci\u00f3n, v\u00f3mitos, az\u00facar bajo en sangre, m\u00fasculos r\u00edgidos o fl\u00e1cidos, reflejos intensos, \ntemblor, nerviosidad, irritabilidad, letargia, llanto continuo, somnolencia y dificultades para \ndormir. Estos s\u00edntomas comien zan normalmente durante las primeras 24 horas tras el \nnacimiento del beb\u00e9. Si su beb\u00e9 presenta cualquiera de estos s\u00edntomas, contacte con su m\u00e9dico inmediatamente.  \nA su vez, aseg\u00farese de que su m\u00e9dico sepa que usted est\u00e1 tomando este medicamento. \nCuando se toman durante el embarazo, especialmente en los \u00faltimos 3 meses de embarazo, \npueden aumentar el riesgo de una enfermedad grave en el beb\u00e9, llamada hipertensi\u00f3n", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "ea7cff7b-7b84-49ce-8056-88d34c67e2ea": {"__data__": {"id_": "ea7cff7b-7b84-49ce-8056-88d34c67e2ea", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and precautions associated with taking Vortioxetine during pregnancy?\n2. Can Vortioxetine pass into breast milk, and should it be avoided while breastfeeding?\n3. Does Vortioxetine have any impact on a person's ability to drive or operate machinery, and are there any specific precautions to take while using this medication?", "prev_section_summary": "The key topics of this section are the potential risks and side effects of using Vortioxetine during pregnancy. It mentions that Vortioxetine should not be used during pregnancy unless absolutely necessary, and if the benefits outweigh the possible risks to the fetus. It also states that if Vortioxetine is taken during the last 3 months of pregnancy, certain effects may be observed in the newborn, such as breathing problems, blue skin, seizures, and difficulty feeding. The section advises pregnant women to contact their doctor immediately if their baby exhibits any of these symptoms after birth. The key entities mentioned in this section are Vortioxetine, pregnancy, newborn, and the potential symptoms in the baby.", "section_summary": "The key topics of this section are the potential risks and precautions associated with taking Vortioxetine during pregnancy, the impact of Vortioxetine on breastfeeding, and the effects of Vortioxetine on a person's ability to drive or operate machinery. The entities mentioned include Vortioxetine, pregnancy, breastfeeding, hypotension, newborn, doctor, lactation, and medication.", "excerpt_keywords": "medicamento, embarazo, riesgo, hipertensi\u00f3n pulmonar persistente del reci\u00e9n nacido, lactancia, leche materna, interrupci\u00f3n, conducci\u00f3n, m\u00e1quinas, efectos secundarios, mareos, tratamiento, dosis, actividades, otros medicamentos"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "50e1d3a1c12cb22d3d1c47d1c0cf4a4726d4bf13773f87da8ebc4ed27c0f213b"}, "2": {"node_id": "260e388b-8c94-4b17-b39e-5b122bbe644f", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "0b3af772ddf2bddae91c03cfaf8d8e83a7bb158ac426ae11832faabb14f11d50"}, "3": {"node_id": "02c8e2f2-b066-4566-a57e-185c910672a5", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4cf763c0ba356a8ecfb3751bcf13dac137fd3afdf12510ebd96fe1041b417f1c"}}, "hash": "cee9353471cf98ec1b1e59fcb4d9a29e77a8c7116922aa51e4eeba6f40a6b633", "text": "A su vez, aseg\u00farese de que su m\u00e9dico sepa que usted est\u00e1 tomando este medicamento. \nCuando se toman durante el embarazo, especialmente en los \u00faltimos 3 meses de embarazo, \npueden aumentar el riesgo de una enfermedad grave en el beb\u00e9, llamada hipertensi\u00f3n \npulmonar persistente del reci\u00e9n nacido (HPPN), haciendo que el beb\u00e9 respire m\u00e1s r\u00e1pido y \nadopte un color azulado. Si esto le ocurre a su beb\u00e9, debe contactar con su m\u00e9dico \ninmediatamente.  \nLactancia: Se prev\u00e9 que los ingredientes de Vortioxetina pasen a la leche materna, por lo tanto, este medicamento no debe usarse durante la lactancia. Su m\u00e9dico de cidir\u00e1 si debe \ninterrumpir la lactancia o dejar de usar Vortioxetina, teniendo en cuenta el beneficio de la \nlactancia para el ni\u00f1o y el beneficio del tratamiento para usted.  \nCONDUCCI\u00d3N Y USO DE MAQUINAS  \nVortioxetina tiene poca o nula influencia sobre la ca pacidad de conducir o utilizar m\u00e1quinas. \nSin embargo, ya que se han reportado efectos secundarios tales como mareos, se recomienda \nprecauci\u00f3n durante este tipo de actividades al principio del tratamiento o al cambiar de dosis.  \nUSO DE OTROS MEDICAMENTOS  \nInforme a su m\u00e9dico si est\u00e1 tomando, ha tomado recientemente o podr\u00eda tener que tomar", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "02c8e2f2-b066-4566-a57e-185c910672a5": {"__data__": {"id_": "02c8e2f2-b066-4566-a57e-185c910672a5", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when starting or changing the dosage of Vortioxetine due to reported side effects such as dizziness?\n2. What other medications should be avoided while taking Vortioxetine, including those that can cause a decrease in sodium levels and irreversible or non-selective MAOIs?\n3. Is it safe to combine Vortioxetine with a weak reversible and non-selective MAOI like linezolid, and if necessary, what precautions should be taken?", "prev_section_summary": "The key topics of this section are the potential risks and precautions associated with taking Vortioxetine during pregnancy, the impact of Vortioxetine on breastfeeding, and the effects of Vortioxetine on a person's ability to drive or operate machinery. The entities mentioned include Vortioxetine, pregnancy, breastfeeding, hypotension, newborn, doctor, lactation, and medication.", "section_summary": "The key topics of this section are precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section discusses the precautions that should be taken when starting or changing the dosage of Vortioxetine due to reported side effects such as dizziness. It also mentions other medications that should be avoided while taking Vortioxetine, including those that can cause a decrease in sodium levels and irreversible or non-selective MAOIs. The section concludes by stating that combining Vortioxetine with a weak reversible and non-selective MAOI like linezolid is contraindicated, but if necessary, the added medication should be given at the minimum dose and closely monitored for serotonin syndrome.", "excerpt_keywords": "mareos, efectos secundarios, precauci\u00f3n, tratamiento, cambiar de dosis, medicamentos, niveles de sodio, IMAO irreversibles, fenelzina, iproniazida, isocarboxazida, nialamida, tranilcipromina, riesgo de SS, Vortioxetina, 14 d\u00edas, IMAO reversible, linezolid, contraindicada, monitorizaci\u00f3n estrecha."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "50e1d3a1c12cb22d3d1c47d1c0cf4a4726d4bf13773f87da8ebc4ed27c0f213b"}, "2": {"node_id": "ea7cff7b-7b84-49ce-8056-88d34c67e2ea", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "cee9353471cf98ec1b1e59fcb4d9a29e77a8c7116922aa51e4eeba6f40a6b633"}, "3": {"node_id": "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "3f8fab90b70fad820d86b8270f49d158755cc2bbde327840bbe160e1268e3853"}}, "hash": "4cf763c0ba356a8ecfb3751bcf13dac137fd3afdf12510ebd96fe1041b417f1c", "text": "Sin embargo, ya que se han reportado efectos secundarios tales como mareos, se recomienda \nprecauci\u00f3n durante este tipo de actividades al principio del tratamiento o al cambiar de dosis.  \nUSO DE OTROS MEDICAMENTOS  \nInforme a su m\u00e9dico si est\u00e1 tomando, ha tomado recientemente o podr\u00eda tener que tomar \ncualquier otro medicamento, incluso los adquiridos sin receta. En particular:  \n- Medicamentos que se sabe que causan disminuci\u00f3n en los niveles de sodio.  \n- IMAO irreversibles  y no selectivos: como fenelzina, iproniazida, isocarboxazida, \nnialamida, tranilcipromina (medicamentos para tratar la depresi\u00f3n). Debido al riesgo de SS no \ndebe tomar ninguno de estos medicamentos con Vortioxetina. Si ha tomado alguno de estos \nmedicamento s, debe esperar 14 d\u00edas antes de empezar a tomar Vortioxetina. Despu\u00e9s de \nsuspender Vortioxetina, debe esperar 14 d\u00edas antes de tomar cualquiera de estos medicamentos. \n- IMAO reversible y no selectivo: la combinaci\u00f3n de Vortioxetina con un IMAO reversible \ny no selectivo d\u00e9bil como linezolid (medicamento para tratar infecciones bacterianas) est\u00e1 \ncontraindicada. Si la combinaci\u00f3n fuera necesaria, el medicamento a\u00f1adido debe darse a la \ndosis m\u00ednima y bajo una monitorizaci\u00f3n estrecha del SS.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d": {"__data__": {"id_": "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What is the contraindication for combining Vortioxetine with a weak non-selective reversible MAOI like linezolid?\n2. What precautions should be taken when combining Vortioxetine with a reversible and selective MAO-A inhibitor like moclobemide?\n3. What is the recommended dosage and monitoring approach when combining Vortioxetine with an additional medication?", "prev_section_summary": "The key topics of this section are precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section discusses the precautions that should be taken when starting or changing the dosage of Vortioxetine due to reported side effects such as dizziness. It also mentions other medications that should be avoided while taking Vortioxetine, including those that can cause a decrease in sodium levels and irreversible or non-selective MAOIs. The section concludes by stating that combining Vortioxetine with a weak reversible and non-selective MAOI like linezolid is contraindicated, but if necessary, the added medication should be given at the minimum dose and closely monitored for serotonin syndrome.", "section_summary": "The key topics of this section are the contraindications and precautions for combining Vortioxetine with certain medications. The section specifically mentions the contraindication of combining Vortioxetine with a weak non-selective reversible MAOI like linezolid. It also discusses the precautions that should be taken when combining Vortioxetine with a reversible and selective MAO-A inhibitor like moclobemide. Additionally, the section mentions the recommended dosage and monitoring approach when combining Vortioxetine with an additional medication. The entities mentioned in this section include Vortioxetine, linezolid, moclobemide, and MAO-A.", "excerpt_keywords": "IMAO reversible, IMAO no selectivo, Vortioxetina, linezolid, contraindicaci\u00f3n, dosis m\u00ednima, monitorizaci\u00f3n estrecha, inhibidor de la MAO-A, selectivo, moclobemida, tratamiento, infecciones bacterianas, SS, combinaci\u00f3n, medicamento, reversible, monitorizaci\u00f3n."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "50e1d3a1c12cb22d3d1c47d1c0cf4a4726d4bf13773f87da8ebc4ed27c0f213b"}, "2": {"node_id": "02c8e2f2-b066-4566-a57e-185c910672a5", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4cf763c0ba356a8ecfb3751bcf13dac137fd3afdf12510ebd96fe1041b417f1c"}}, "hash": "3f8fab90b70fad820d86b8270f49d158755cc2bbde327840bbe160e1268e3853", "text": "- IMAO reversible y no selectivo: la combinaci\u00f3n de Vortioxetina con un IMAO reversible \ny no selectivo d\u00e9bil como linezolid (medicamento para tratar infecciones bacterianas) est\u00e1 \ncontraindicada. Si la combinaci\u00f3n fuera necesaria, el medicamento a\u00f1adido debe darse a la \ndosis m\u00ednima y bajo una monitorizaci\u00f3n estrecha del SS.  \n- Inhibidor de la M AO-A reversible y selectivo: la combinaci\u00f3n de Vortioxetina con un \ninhibidor de la MAO-A reversible y selectivo como moclobemida (medicamento para tratar la", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "1895eefa-e41f-40f0-88a5-dc52f54f61a2": {"__data__": {"id_": "1895eefa-e41f-40f0-88a5-dc52f54f61a2", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and precautions associated with combining Vortioxetine with irreversible and selective MAO-B inhibitors?\n2. Can the concurrent use of Vortioxetine and medications with serotoninergic effects, such as tramadol or sumatriptan, lead to serotonin syndrome?\n3. How does the use of Vortioxetine in combination with medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs, affect the risk of seizures?", "prev_section_summary": "The key topics of this section are the contraindications and precautions for combining Vortioxetine with certain medications. The section specifically mentions the contraindication of combining Vortioxetine with a weak non-selective reversible MAOI like linezolid. It also discusses the precautions that should be taken when combining Vortioxetine with a reversible and selective MAO-A inhibitor like moclobemide. Additionally, the section mentions the recommended dosage and monitoring approach when combining Vortioxetine with an additional medication. The entities mentioned in this section include Vortioxetine, linezolid, moclobemide, and MAO-A.", "section_summary": "The section discusses the potential risks and precautions associated with combining Vortioxetine with certain medications. The key topics include the combination of Vortioxetine with irreversible and selective MAO-B inhibitors, medications with serotoninergic effects, such as tramadol or sumatriptan, and medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs. The section also mentions the contraindication of combining Vortioxetine with St. John's Wort. The key entities mentioned are Vortioxetine, irreversible and selective MAO-B inhibitors, tramadol, sumatriptan, St. John's Wort, tricyclic antidepressants, and SSRIs.", "excerpt_keywords": "depresi\u00f3n, contraindicaci\u00f3n, combinaci\u00f3n, dosis m\u00ednima, monitorizaci\u00f3n cl\u00ednica, SS, inhibidores de la MAO-B, selegilina, rasagilina, enfermedad de Parkinson, precauci\u00f3n, medicamentos serotonin\u00e9rgicos, tramadol, sumatript\u00e1n, -tript\u00e1n, migra\u00f1a, Hierba de San Juan, Hypericum perforatum, reacciones adversas, umbral convulsivo, antidepresivos tric\u00edclicos, ISRS, IRSN."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "9e4a9e7bcf5017a6fac43ab8d0d08c61af6b5327f97ba9be32a60c0f1d828585"}, "3": {"node_id": "f1e2a382-4ccd-4a49-9eb6-36482b21e060", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4c01ae808cf9ba9098431907d512ce70f0cee296fc5c64cb5265cb74c3d4ceeb"}}, "hash": "6493cd35493399b37d1ea7ec36769be534a2c55fb5c8b27e23edbcf08e9cabdd", "text": "depresi\u00f3n) est\u00e1 contraindicada. Si la combinaci\u00f3n fuera necesaria, la adici\u00f3n del medicamento \ndeber \u00eda darse a dosis m\u00ednima y bajo estrecha monitorizaci\u00f3n cl\u00ednica para detectar la aparici\u00f3n \ndel SS.  \n- Inhibidores de la MAO-B irreversibles y selectivos: la combinaci\u00f3n de Vortioxetina con \ninhibidores de la MAO -B irreversibles, como la selegilina o la rasagi lina (medicamentos para \ntratar la enfermedad de Parkinson), se debe administrar con precauci\u00f3n. Si se utilizan de manera simult\u00e1nea, se debe estrechar la monitorizaci\u00f3n para detectar la aparici\u00f3n de SS.  \n- Medicamentos serotonin\u00e9rgicos: la administraci\u00f3n co njunta de medicamentos con \nefecto serotonin\u00e9rgico como tramadol (un fuerte analg\u00e9sico), sumatript\u00e1n y medicamentos \nsimilares con nombres de principios activos terminados en \u201c -tript\u00e1n\u201d (utilizados para tratar la \nmigra\u00f1a) puede provocar SS.  \n- Hierba de San J uan (Hypericum perforatum) (medicamento para tratar la depresi\u00f3n). El \nuso concomitante puede aumentar la incidencia de reacciones adversas, incluido el SS.  \n- Medicamentos que disminuyen el umbral convulsivo: Vortioxetina puede disminuir el \numbral convulsiv o. Se recomienda precauci\u00f3n cuando se utilice de manera simult\u00e1nea con \notros medicamentos capaces de disminuir este umbral: antidepresivos tric\u00edclicos, ISRS, IRSN", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "f1e2a382-4ccd-4a49-9eb6-36482b21e060": {"__data__": {"id_": "f1e2a382-4ccd-4a49-9eb6-36482b21e060", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when using Vortioxetine in combination with other medications that lower the seizure threshold?\n2. Is there any clinical experience regarding the concurrent administration of electroconvulsive therapy (ECT) and Vortioxetine?\n3. Are there any dosage adjustments required when Vortioxetine is used with inhibitors of CYP3A4, CYP2C9, and CYP2C19?\n\nHigher-level summary: This context provides information about precautions and potential interactions of Vortioxetine with other medications and therapies. It highlights the need for caution when using Vortioxetine with medications that lower the seizure threshold, lack of clinical experience with concurrent use of electroconvulsive therapy, and the absence of dosage adjustments when used with certain enzyme inhibitors.", "prev_section_summary": "The section discusses the potential risks and precautions associated with combining Vortioxetine with certain medications. The key topics include the combination of Vortioxetine with irreversible and selective MAO-B inhibitors, medications with serotoninergic effects, such as tramadol or sumatriptan, and medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs. The section also mentions the contraindication of combining Vortioxetine with St. John's Wort. The key entities mentioned are Vortioxetine, irreversible and selective MAO-B inhibitors, tramadol, sumatriptan, St. John's Wort, tricyclic antidepressants, and SSRIs.", "section_summary": "The key topics of this section are precautions and potential interactions of Vortioxetine with other medications and therapies. The section discusses the need for caution when using Vortioxetine with medications that lower the seizure threshold, the lack of clinical experience with concurrent use of electroconvulsive therapy, and the absence of dosage adjustments when used with certain enzyme inhibitors. The entities mentioned in this section include Vortioxetine, medications that lower the seizure threshold (such as tricyclic antidepressants, selective serotonin reuptake inhibitors, and neuroleptics), mefloquine, bupropion, tramadol, electroconvulsive therapy, inhibitors of CYP3A4, CYP2C9, and CYP2C19 (such as ketoconazole, fluconazole, and omeprazole), and poor metabolizers of CYP2D6.", "excerpt_keywords": "Vortioxetina, umbral convulsivo, medicamentos, precauci\u00f3n, antidepresivos tric\u00edclicos, ISRS, IRSN, neurol\u00e9pticos, mefloquina, bupropi\u00f3n, tramadol, terapia electroconvulsiva, inhibidores de la CYP3A4, CYP2C9, CYP2C19, ketoconazol, fluconazol, omeprazol, metabolizadores pobres, CYP2D6, inhibidor potente."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "9e4a9e7bcf5017a6fac43ab8d0d08c61af6b5327f97ba9be32a60c0f1d828585"}, "2": {"node_id": "1895eefa-e41f-40f0-88a5-dc52f54f61a2", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "6493cd35493399b37d1ea7ec36769be534a2c55fb5c8b27e23edbcf08e9cabdd"}, "3": {"node_id": "9452c1be-1edb-456a-a85a-43cb62f83b4e", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4fc35df3be392d92a23bce5c184a529d65b575c1ef9bf08b19503fb0e2daad20"}}, "hash": "4c01ae808cf9ba9098431907d512ce70f0cee296fc5c64cb5265cb74c3d4ceeb", "text": "- Medicamentos que disminuyen el umbral convulsivo: Vortioxetina puede disminuir el \numbral convulsiv o. Se recomienda precauci\u00f3n cuando se utilice de manera simult\u00e1nea con \notros medicamentos capaces de disminuir este umbral: antidepresivos tric\u00edclicos, ISRS, IRSN \n(fluoxetina, paroxetina), neurol\u00e9pticos (fenotiazinas, tioxantenos y butirofenonas), mefloqui na \n(medicamento para prevenir y tratar la malaria), bupropi\u00f3n (medicamento para tratar la depresi\u00f3n tambi\u00e9n utilizado para dejar de fumar) y tramadol. Por favor hable con su m\u00e9dico si \nusted est\u00e1 tomando alguno de los medicamentos mencionados, ya que su m\u00e9d ico necesita \nsaber si usted tiene riesgo de sufrir convulsiones.  \n- Terapia electroconvulsiva ( TEC): no hay experiencia cl\u00ednica sobre la administraci\u00f3n \nconcomitante de TEC y Vortioxetina, por lo que se recomienda precauci\u00f3n.  \n- Inhibidores de la CYP3A4, la CYP2C9 y la CYP2C19 como ketoconazol, fluconazol, \nomeprazol. No se requiere un ajuste de la dosis. \n- Interacciones en metabolizadores pobres de la CYP2D6: Seg\u00fan la respuesta individual \ndel paciente, se puede considerar una dosis m\u00e1s baja de Vortioxetina si  se administra de forma \nconjunta un inhibidor potente de la CYP3A4 (como el itraconazol, voriconazol, claritromicina,", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "9452c1be-1edb-456a-a85a-43cb62f83b4e": {"__data__": {"id_": "9452c1be-1edb-456a-a85a-43cb62f83b4e", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when combining Vortioxetine with anticoagulants or antiaggregants?\n2. Are there any potential interactions between Vortioxetine and omeprazole?\n3. How does the administration of Vortioxetine affect the levels of hormones in the body when taken with an oral contraceptive?", "prev_section_summary": "The key topics of this section are precautions and potential interactions of Vortioxetine with other medications and therapies. The section discusses the need for caution when using Vortioxetine with medications that lower the seizure threshold, the lack of clinical experience with concurrent use of electroconvulsive therapy, and the absence of dosage adjustments when used with certain enzyme inhibitors. The entities mentioned in this section include Vortioxetine, medications that lower the seizure threshold (such as tricyclic antidepressants, selective serotonin reuptake inhibitors, and neuroleptics), mefloquine, bupropion, tramadol, electroconvulsive therapy, inhibitors of CYP3A4, CYP2C9, and CYP2C19 (such as ketoconazole, fluconazole, and omeprazole), and poor metabolizers of CYP2D6.", "section_summary": "The key topics of this section are precautions and potential interactions of Vortioxetine with other medications. The section mentions precautions when combining Vortioxetine with anticoagulants or antiaggregants, potential interactions with omeprazole, the effect of Vortioxetine on hormone levels when taken with an oral contraceptive, and the caution needed when using Vortioxetine with lithium and tryptophan. The entities mentioned in this section include anticoagulants, antiaggregants, omeprazole, CYP2D6, CYP3A4, CYP2C9, warfarin, dipiridamol, fenprocum\u00f3n, \u00e1cido acetilsalic\u00edlico, diazepam, hormones, etinil estradiol, levonorgestrel, lithium, and tryptophan.", "excerpt_keywords": "omeprazol, ajuste de dosis, interacciones, metabolizadores pobres, CYP2D6, inhibidor potente, CYP3A4, itraconazol, voriconazol, claritromicina, telitromicina, nefazodona, conivaptan, inhibidores de la proteasa del VIH, CYP2C9, fluconazol, amiodarona, anticoagulantes, antiagregantes plaquetarios, warfarina, dipiridamol, fenprocum\u00f3n, \u00e1cido acetilsalic\u00edlico, hemorragia, diazepam, funci\u00f3n cognitiva, hormonas sexuales, anticonceptivo oral combinado, litio, tript\u00f3fano, precauci\u00f3n."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "9e4a9e7bcf5017a6fac43ab8d0d08c61af6b5327f97ba9be32a60c0f1d828585"}, "2": {"node_id": "f1e2a382-4ccd-4a49-9eb6-36482b21e060", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4c01ae808cf9ba9098431907d512ce70f0cee296fc5c64cb5265cb74c3d4ceeb"}, "3": {"node_id": "9b2d3a5b-c571-40fe-9202-26acd06c2564", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "668b4645e65ea2ed49e0ff9332f7fa4aea0f2815de6a5585607d5a0d6ffcebba"}}, "hash": "4fc35df3be392d92a23bce5c184a529d65b575c1ef9bf08b19503fb0e2daad20", "text": "omeprazol. No se requiere un ajuste de la dosis. \n- Interacciones en metabolizadores pobres de la CYP2D6: Seg\u00fan la respuesta individual \ndel paciente, se puede considerar una dosis m\u00e1s baja de Vortioxetina si  se administra de forma \nconjunta un inhibidor potente de la CYP3A4 (como el itraconazol, voriconazol, claritromicina, \ntelitromicina, nefazodona, conivaptan, y muchos de los inhibidores de la proteasa del VIH) o de \nla CYP2C9 (como fluconazol y amiodarona) e n pacientes metabolizadores lentos de la CYP2D6.  \n- Anticoagulantes y antiagregantes plaquetarios: se debe tener precauci\u00f3n al combinar \nla Vortioxetina  con anticoagulantes o antiagregantes plaquetarios orales como warfarina, \ndipiridamol, fenprocum\u00f3n, \u00e1cido acetilsalic\u00edlico, debido al potencial aumento del riesgo de hemorragia.  \n- La administraci\u00f3n conjunta con diazepam parece no alterar la funci\u00f3n cogniti va. \n- No se observaron cambios en los niveles de hormonas sexuales despu\u00e9s de la \nadministraci\u00f3n conjunta de Vortioxetina con el anticonceptivo oral combinado (etinil estradiol \n30 \u00b5g/ levonorgestrel 150 \u00b5g).  \n- Litio (medicamento para tratar la depresi\u00f3n y l os trastornos mentales) y tript\u00f3fano: el \nuso concomitante de Vortioxetina con estos medicamentos se debe realizar con precauci\u00f3n.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "9b2d3a5b-c571-40fe-9202-26acd06c2564": {"__data__": {"id_": "9b2d3a5b-c571-40fe-9202-26acd06c2564", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the precautions and risks associated with combining Vortioxetine with the oral contraceptive pill containing ethinyl estradiol and levonorgestrel?\n2. How should Vortioxetine be used cautiously when taken together with lithium and tryptophan, medications used to treat depression and mental disorders?\n3. Is there any specific information regarding the administration of Vortioxetine with food and beverages?", "prev_section_summary": "The key topics of this section are precautions and potential interactions of Vortioxetine with other medications. The section mentions precautions when combining Vortioxetine with anticoagulants or antiaggregants, potential interactions with omeprazole, the effect of Vortioxetine on hormone levels when taken with an oral contraceptive, and the caution needed when using Vortioxetine with lithium and tryptophan. The entities mentioned in this section include anticoagulants, antiaggregants, omeprazole, CYP2D6, CYP3A4, CYP2C9, warfarin, dipiridamol, fenprocum\u00f3n, \u00e1cido acetilsalic\u00edlico, diazepam, hormones, etinil estradiol, levonorgestrel, lithium, and tryptophan.", "section_summary": "The section discusses the precautions and risks associated with combining Vortioxetine with the oral contraceptive pill containing ethinyl estradiol and levonorgestrel. It also mentions the cautious use of Vortioxetine when taken together with lithium and tryptophan, medications used to treat depression and mental disorders. Additionally, there is information regarding the administration of Vortioxetine with food and beverages.", "excerpt_keywords": "administraci\u00f3n conjunta, Vortioxetina, anticonceptivo oral combinado, etinil estradiol, levonorgestrel, litio, tript\u00f3fano, depresi\u00f3n, trastornos mentales, precauci\u00f3n, alimentos, bebidas."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "9e4a9e7bcf5017a6fac43ab8d0d08c61af6b5327f97ba9be32a60c0f1d828585"}, "2": {"node_id": "9452c1be-1edb-456a-a85a-43cb62f83b4e", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4fc35df3be392d92a23bce5c184a529d65b575c1ef9bf08b19503fb0e2daad20"}}, "hash": "668b4645e65ea2ed49e0ff9332f7fa4aea0f2815de6a5585607d5a0d6ffcebba", "text": "administraci\u00f3n conjunta de Vortioxetina con el anticonceptivo oral combinado (etinil estradiol \n30 \u00b5g/ levonorgestrel 150 \u00b5g).  \n- Litio (medicamento para tratar la depresi\u00f3n y l os trastornos mentales) y tript\u00f3fano: el \nuso concomitante de Vortioxetina con estos medicamentos se debe realizar con precauci\u00f3n.  \nTOMA DE VORTIOXETINA CON ALIMENTOS Y BEBIDAS", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "f0c7c151-f604-4ab6-b62d-fb97e74e7ee4": {"__data__": {"id_": "f0c7c151-f604-4ab6-b62d-fb97e74e7ee4", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the possible side effects of taking Vortioxetine and when do they typically occur?\n2. Can Vortioxetine be taken with alcohol?\n3. What are the precautions and contraindications for using Vortioxetine to treat major depression in adults?", "prev_section_summary": "The section discusses the precautions and risks associated with combining Vortioxetine with the oral contraceptive pill containing ethinyl estradiol and levonorgestrel. It also mentions the cautious use of Vortioxetine when taken together with lithium and tryptophan, medications used to treat depression and mental disorders. Additionally, there is information regarding the administration of Vortioxetine with food and beverages.", "section_summary": "The section discusses the precautions, contraindications, and possible side effects of taking Vortioxetine, a medication used to treat major depression in adults. It mentions that the tablets can be taken with or without food, but it is not recommended to combine the medication with alcohol. The possible side effects are generally mild or moderate and occur within the first two weeks of treatment. Some of the common side effects include nausea, diarrhea, constipation, vomiting, dizziness, itching, abnormal dreams, and flushing of the skin. It also mentions that low levels of sodium in the blood may occur, which can cause symptoms such as dizziness and weakness.", "excerpt_keywords": "Vortioxetina, comprimidos, alimentos, combinaci\u00f3n, alcohol, efectos adversos, n\u00e1useas, diarrea, estre\u00f1imiento, v\u00f3mitos, mareo, prurito, picor, sue\u00f1os anormales, rubefacci\u00f3n, enrojecimiento de la piel, sudores nocturnos, niveles bajos de sodio en sangre, sensaci\u00f3n de mareo, debilidad."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "d69ca6ed-f926-4841-a592-7fc400f9002f", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "15672c146b9f69e5a1a0a6e3c64bcd7f135956b6d2acd2b520e18f97afa75470"}, "3": {"node_id": "c44684d7-a3f9-4d0e-a0bf-539a90eb853b", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "e45eeff75717c2d7b5cf0b6036dfc0b00ad01c1967a360a5ff041e712791f643"}}, "hash": "ed84bb54a758054a23657e4e2676944504537e1d8962a018494531ec8e6f1f1c", "text": "Los comprimidos de Vortioxetina se pueden tomar con o sin alimentos. No se aconseja la \ncombinaci\u00f3n de este medicamento con alcohol.  \nPOSIBLES EFECTOS ADVERSOS  \nAl igual que todos los medicamentos, este medicamento puede producir efectos adversos, \naunque no todas las personas los sufran.  \nLos efectos adversos observados fueron en su mayor\u00ed a leves o moderados y se produjeron en \nlas primeras dos semanas de tratamiento. Estos efectos fueron, por lo general, transitorios y \nno requirieron la suspensi\u00f3n del tratamiento.  \nSe han observado los siguientes efectos adversos con las frecuencias que se i ndican:  \n- Muy frecuentes (pueden afectar a m\u00e1s de 1 de cada 10 personas): n\u00e1useas.  \n- Frecuentes (pueden afectar hasta 1 de cada 10 personas): diarrea, estre\u00f1imiento, \nv\u00f3mitos; mareo; prurito incluyendo picor en todo el cuerpo; sue\u00f1os anormales.  \n- Poco frecu entes (pueden afectar hasta 1 de cada 100 personas): rubefacci\u00f3n \n(enrojecimiento de la piel); sudores nocturnos.  \n- Frecuencia no conocida (no puede estimarse a partir de los datos disponibles): niveles \nbajos de sodio en sangre (algunos de los s\u00edntomas pued en ser sensaci\u00f3n de mareo, debilidad,", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "c44684d7-a3f9-4d0e-a0bf-539a90eb853b": {"__data__": {"id_": "c44684d7-a3f9-4d0e-a0bf-539a90eb853b", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential side effects of taking Vortioxetine for treating major depression in adults?\n2. What are the rare side effects of Vortioxetine, such as low sodium levels in the blood and serotonin syndrome?\n3. What are the risks associated with taking a 20 mg dose of Vortioxetine, including sexual dysfunction and increased risk of bone fractures in patients aged 50 or older?", "prev_section_summary": "The section discusses the precautions, contraindications, and possible side effects of taking Vortioxetine, a medication used to treat major depression in adults. It mentions that the tablets can be taken with or without food, but it is not recommended to combine the medication with alcohol. The possible side effects are generally mild or moderate and occur within the first two weeks of treatment. Some of the common side effects include nausea, diarrhea, constipation, vomiting, dizziness, itching, abnormal dreams, and flushing of the skin. It also mentions that low levels of sodium in the blood may occur, which can cause symptoms such as dizziness and weakness.", "section_summary": "The key topics of this section are the potential side effects of taking Vortioxetine for treating major depression in adults. The section mentions common side effects such as skin redness and night sweats, as well as rare side effects including low sodium levels in the blood, serotonin syndrome, allergic reactions, and excessive or unexplained bleeding. It also highlights the risks associated with taking a 20 mg dose of Vortioxetine, such as sexual dysfunction and an increased risk of bone fractures in patients aged 50 or older. The section advises individuals to consult their doctor if they experience any adverse effects.", "excerpt_keywords": "rubefacci\u00f3n, enrojecimiento de la piel, sudores nocturnos, niveles bajos de sodio en sangre, sensaci\u00f3n de mareo, debilidad, confusi\u00f3n, somnolencia, cansancio, n\u00e1useas, v\u00f3mitos, S\u00edndrome Serotonin\u00e9rgico, reacciones al\u00e9rgicas, hinchaz\u00f3n, dificultad para respirar, dificultad para tragar, descenso repentino de la presi\u00f3n arterial, urticaria, erupci\u00f3n, sangrado excesivo, contusi\u00f3n, hematomas, hemorragia nasal, sangrado gastrointestinal, sangrado vaginal, disfunci\u00f3n sexual, TESD, riesgo de fracturas \u00f3seas, medicamento, efecto adverso, m\u00e9dico"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "d69ca6ed-f926-4841-a592-7fc400f9002f", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "15672c146b9f69e5a1a0a6e3c64bcd7f135956b6d2acd2b520e18f97afa75470"}, "2": {"node_id": "f0c7c151-f604-4ab6-b62d-fb97e74e7ee4", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "ed84bb54a758054a23657e4e2676944504537e1d8962a018494531ec8e6f1f1c"}, "3": {"node_id": "04bfad7a-0c57-4de6-bd62-1ddf54451460", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "d998cff15e5aece521f7afc83b0441369edb495869b95d815b9dde7d55f7c2ab"}}, "hash": "e45eeff75717c2d7b5cf0b6036dfc0b00ad01c1967a360a5ff041e712791f643", "text": "- Poco frecu entes (pueden afectar hasta 1 de cada 100 personas): rubefacci\u00f3n \n(enrojecimiento de la piel); sudores nocturnos.  \n- Frecuencia no conocida (no puede estimarse a partir de los datos disponibles): niveles \nbajos de sodio en sangre (algunos de los s\u00edntomas pued en ser sensaci\u00f3n de mareo, debilidad, \nconfusi\u00f3n, somnolencia o mucho cansancio, o bien tener n\u00e1useas o v\u00f3mitos; otros s\u00edntomas m\u00e1s graves son desmayos, convulsiones o ca\u00eddas); S\u00edndrome Serotonin\u00e9rgico; reacciones \nal\u00e9rgicas (reacciones anafil\u00e1cticas), que pueden ser graves, y provocar hinchaz\u00f3n de la cara, los \nlabios, la lengua o la garganta; dificultad para respirar o tragar, y/o descenso repentino de la \npresi\u00f3n arterial (que puede hacer que se sienta mareado o aturdido); urticaria, erupci\u00f3n; \nsangrado excesivo o inexplicable (incluyendo contusi\u00f3n, hematomas, hemorragia nasal, \nsangrado gastrointestinal y vaginal).  \nPor otro lado, la dosis de Vortioxetina de 20 mg se asoci\u00f3 con un incremento en disfunci\u00f3n \nsexual (TESD). A su vez, se ha observado un incremento del riesgo de fracturas \u00f3seas en \npacientes que toman este tipo de medicamentos y tienen 50 a\u00f1os o m\u00e1s. \nSi experimenta cualquier tipo de efecto adverso, consulte a su m\u00e9dico, incluso si se trata de", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "04bfad7a-0c57-4de6-bd62-1ddf54451460": {"__data__": {"id_": "04bfad7a-0c57-4de6-bd62-1ddf54451460", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the recommended dosages of Vortioxetine for adults under 65 years old and for elderly patients?\n2. Are there any specific precautions or contraindications for taking Vortioxetine in patients over 50 years old?\n3. What are the potential side effects of Vortioxetine and when should a patient consult their doctor about them?", "prev_section_summary": "The key topics of this section are the potential side effects of taking Vortioxetine for treating major depression in adults. The section mentions common side effects such as skin redness and night sweats, as well as rare side effects including low sodium levels in the blood, serotonin syndrome, allergic reactions, and excessive or unexplained bleeding. It also highlights the risks associated with taking a 20 mg dose of Vortioxetine, such as sexual dysfunction and an increased risk of bone fractures in patients aged 50 or older. The section advises individuals to consult their doctor if they experience any adverse effects.", "section_summary": "The key topics of this section are the recommended dosages of Vortioxetine for adults under 65 years old and for elderly patients, precautions and contraindications for taking Vortioxetine in patients over 50 years old, and potential side effects of Vortioxetine. The key entities mentioned are Vortioxetine, adults under 65 years old, elderly patients, and patients over 50 years old.", "excerpt_keywords": "Vortioxetina, medicamento, efectos adversos, prospecto, dosis, administraci\u00f3n, agua, alimentos, respuesta al tratamiento, edad avanzada, precauci\u00f3n, pacientes, incremento del riesgo, fracturas \u00f3seas, m\u00e9dico, consulte, posibles efectos adversos, comprimidos, 65 a\u00f1os o m\u00e1s."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "d69ca6ed-f926-4841-a592-7fc400f9002f", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "15672c146b9f69e5a1a0a6e3c64bcd7f135956b6d2acd2b520e18f97afa75470"}, "2": {"node_id": "c44684d7-a3f9-4d0e-a0bf-539a90eb853b", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "e45eeff75717c2d7b5cf0b6036dfc0b00ad01c1967a360a5ff041e712791f643"}}, "hash": "d998cff15e5aece521f7afc83b0441369edb495869b95d815b9dde7d55f7c2ab", "text": "sexual (TESD). A su vez, se ha observado un incremento del riesgo de fracturas \u00f3seas en \npacientes que toman este tipo de medicamentos y tienen 50 a\u00f1os o m\u00e1s. \nSi experimenta cualquier tipo de efecto adverso, consulte a su m\u00e9dico, incluso si se trata de \nposibles efectos adversos que no aparecen en este prospecto.  \nC\u00d3MO TOMAR VORTIOXETINA \nSiga exactamente las instrucciones de administraci\u00f3n de este medicamento indicadas por su \nm\u00e9dico. En caso de duda, consulte de nuevo con \u00e9l.  \nLos comprimidos se deben tomar con un poco de agua, con o sin alimentos.  \nPosolog\u00eda:  \nAdulo s menores a 65 a\u00f1os: La dosis recomendada de Vortioxetina es 10 mg una vez al d\u00eda. En \nfunci\u00f3n de su respuesta al tratamiento, su m\u00e9dico puede aumentar la dosis hasta un m\u00e1ximo \nde 20 mg de Vortioxetina al d\u00eda o reducirla hasta un m\u00ednimo de 5 mg de Vortioxetina al d\u00eda.  \nPacientes de edad avanzada (65 a\u00f1os o m\u00e1s): Como dosis inicial se debe utilizar siempre la \ndosis eficaz m\u00e1s baja de 5 mg de Vortioxetina una vez al d\u00eda. Se debe tener precauci\u00f3n cuando \nse traten pacientes de \u2265 65 a\u00f1os de edad con dosis superior es a 10 mg de Vortioxetina una vez", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "3dadae44-9de5-46c3-8b83-46f87c49d1c8": {"__data__": {"id_": "3dadae44-9de5-46c3-8b83-46f87c49d1c8", "embedding": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when treating patients with renal or hepatic insufficiency with Vortioxetine?\n2. How should the dosage of Vortioxetine be adjusted when combined with potent inhibitors or inducers of the cytochrome P450 enzyme?\n3. How long should Vortioxetine be taken and for how long after feeling better should the treatment continue?", "prev_section_summary": "The key topics of this section are the recommended dosages of Vortioxetine for adults under 65 years old and for elderly patients, precautions and contraindications for taking Vortioxetine in patients over 50 years old, and potential side effects of Vortioxetine. The key entities mentioned are Vortioxetine, adults under 65 years old, elderly patients, and patients over 50 years old.", "section_summary": "The key topics of this section are precautions and risks associated with the use of Vortioxetine in patients with renal or hepatic insufficiency, dosage adjustment when combined with potent inhibitors or inducers of the cytochrome P450 enzyme, and the recommended duration of treatment. The entities mentioned include Vortioxetine, renal or hepatic insufficiency, inhibitors of the cytochrome P450 enzyme, and inducers of the cytochrome P450 enzyme.", "excerpt_keywords": "ajuste de dosis, funci\u00f3n renal, funci\u00f3n hep\u00e1tica, insuficiencia renal, insuficiencia hep\u00e1tica, precauci\u00f3n, inhibidores del citocromo P450, dosis m\u00e1s baja, inhibidor potente, inductores del citocromo P450, ajuste de dosis, duraci\u00f3n del tratamiento, m\u00e9dico, mejor\u00eda, olvido, Vortioxetina."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "c0bbc515441081827095209e6bf7bcbb7aaed8898c2b875e739b543096639dd9"}, "3": {"node_id": "31dd326c-ab65-4fbc-baa7-2bd9a7365b42", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "0f1aeb691038116e628d30c8c63085f7e8b0ae57d06ef7cea43dde510df0150d"}}, "hash": "63819555553cbe1d1f6ec4b4b29545b7c8f46dd5a49943d47b1bfc27ee6a6e70", "text": "al d\u00eda, ya que los datos son limitados. Insuficiencia renal o hep\u00e1tica: No se requiere un ajuste \nde la dosis sobre la base de la funci\u00f3n renal o hep\u00e1tica. Sin embargo, dado que los sujetos con \ninsuficiencia renal o hep\u00e1ti ca son vulnerables y dado que los datos sobre el uso de Vortioxetina \nen estas subpoblaciones son limitados, se debe tener precauci\u00f3n cuando se traten estos pacientes.  \nInhibidores del citocromo P450: Seg\u00fan la respuesta individual del paciente, se puede \ncons iderar una dosis m\u00e1s baja de Vortioxetina si se a\u00f1ade un inhibidor potente de la CYP2D6 \n(p. ej., bupropi\u00f3n, quinidina, fluoxetina, paroxetina) al tratamiento con Vortioxetina.  \nInductores del citocromo P450: Seg\u00fan la respuesta individual del paciente, se pu ede \nconsiderar un ajuste de la dosis de Vortioxetina si se a\u00f1ade un inductor del citocromo P450 de \namplio espectro (p. ej., rifampicina, carbamazepina, fenito\u00edna) al tratamiento con Vortioxetina. \nDuraci\u00f3n del tratamiento: Tome Vortioxetina durante el tiempo que le indique su m\u00e9dico. \nContin\u00fae tom\u00e1ndolo, aunque tarde cierto tiempo en empezar a notar una mejor\u00eda en su \nestado. Debe continuar con el tratamiento durante al menos 6 meses despu\u00e9s de sentirse bien \nde nuevo.  \nSI OLVID\u00d3 TOMAR VORTIOXETINA", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "31dd326c-ab65-4fbc-baa7-2bd9a7365b42": {"__data__": {"id_": "31dd326c-ab65-4fbc-baa7-2bd9a7365b42", "embedding": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. How long should Vortioxetine be taken for treating major depression in adults?\n2. What should be done if a dose of Vortioxetine is missed?\n3. What are the symptoms of an overdose of Vortioxetine and what should be done in case of overdose?", "prev_section_summary": "The key topics of this section are precautions and risks associated with the use of Vortioxetine in patients with renal or hepatic insufficiency, dosage adjustment when combined with potent inhibitors or inducers of the cytochrome P450 enzyme, and the recommended duration of treatment. The entities mentioned include Vortioxetine, renal or hepatic insufficiency, inhibitors of the cytochrome P450 enzyme, and inducers of the cytochrome P450 enzyme.", "section_summary": "The key topics of this section are the duration of treatment with Vortioxetine for major depression in adults, what to do if a dose is missed, and the symptoms and actions to take in case of an overdose. The entities mentioned include Vortioxetine, the medication being discussed, and the various symptoms of an overdose such as dizziness, nausea, diarrhea, and skin redness.", "excerpt_keywords": "tratamiento, Vortioxetina, m\u00e9dico, duraci\u00f3n, mejor\u00eda, estado, tomar, olvid\u00f3, dosis, interrumpir, consultarlo, gradual, duda, uso, medicamento, sobredosis, ingesti\u00f3n accidental, centro de asistencia m\u00e9dica, Servicio de Informaci\u00f3n Toxicol\u00f3gica, s\u00edntomas, mareo postural, n\u00e1useas, diarrea, molestias estomacales, picor, somnolencia, rubefacci\u00f3n, enrojecimiento de la piel"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "c0bbc515441081827095209e6bf7bcbb7aaed8898c2b875e739b543096639dd9"}, "2": {"node_id": "3dadae44-9de5-46c3-8b83-46f87c49d1c8", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "63819555553cbe1d1f6ec4b4b29545b7c8f46dd5a49943d47b1bfc27ee6a6e70"}, "3": {"node_id": "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "f573c9345e08f7bcb835017ad58a31d27b888fd06f2ffd594cba49d979d81690"}}, "hash": "0f1aeb691038116e628d30c8c63085f7e8b0ae57d06ef7cea43dde510df0150d", "text": "Duraci\u00f3n del tratamiento: Tome Vortioxetina durante el tiempo que le indique su m\u00e9dico. \nContin\u00fae tom\u00e1ndolo, aunque tarde cierto tiempo en empezar a notar una mejor\u00eda en su \nestado. Debe continuar con el tratamiento durante al menos 6 meses despu\u00e9s de sentirse bien \nde nuevo.  \nSI OLVID\u00d3 TOMAR VORTIOXETINA \nTome la sigui ente dosis a la hora habitual. No tome una dosis doble para compensar las dosis \nolvidadas.  \nSI INTERRUMPE EL TRATAMIENTO CON VORTIOXETINA \nNo deje de tomar Vortioxetina sin consultarlo a su m\u00e9dico. Cuando este indicada su \ninterrupci\u00f3n, no se requiere una dis minuci\u00f3n gradual de la dosis.  \nSi tiene cualquier otra duda sobre el uso de este medicamento, pregunte a su m\u00e9dico.  \nSI TOMA M\u00c1S VORTIOXETINA DEL QUE DEBIERA  \nEn caso de sobredosis o ingesti\u00f3n accidental, consulte inmediatamente al centro de asistencia m\u00e9dica m\u00e1s cercano o al Servicio de Informaci\u00f3n Toxicol\u00f3gica de referencia indicando el \nmedicamento y la cantidad ingerida. Se recomienda llevar el envase y el prospecto del \nmedicamento al profesional sanitario.  \nLos s\u00edntomas en caso de sobredosi s son: mareo postural, n\u00e1useas, diarrea, molestias en el \nest\u00f3mago, picor en todo el cuerpo, somnolencia y rubefacci\u00f3n (enrojecimiento de la piel).", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e": {"__data__": {"id_": "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e", "embedding": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the symptoms of an overdose of Vortioxetine and how should it be treated?\n2. What are the different presentations of Vortioxetine available and how many tablets are included in each package?\n3. What precautions should be taken when taking Vortioxetine and what are the contraindications for its use?", "prev_section_summary": "The key topics of this section are the duration of treatment with Vortioxetine for major depression in adults, what to do if a dose is missed, and the symptoms and actions to take in case of an overdose. The entities mentioned include Vortioxetine, the medication being discussed, and the various symptoms of an overdose such as dizziness, nausea, diarrhea, and skin redness.", "section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section also mentions the symptoms of an overdose of Vortioxetine and how it should be treated. Additionally, it provides information about the different presentations of Vortioxetine available and the number of tablets included in each package. The entities mentioned in this section include Vortioxetine, overdose symptoms, treatment, precautions, contraindications, and different presentations of the medication.", "excerpt_keywords": "medicamento, cantidad ingerida, envase, prospecto, profesional sanitario, s\u00edntomas, sobredosis, mareo postural, n\u00e1useas, diarrea, molestias estomacales, picor en el cuerpo, somnolencia, rubefacci\u00f3n, convulsiones, S\u00edndrome Serotonin\u00e9rgico, tratamiento, monitorizaci\u00f3n, seguimiento m\u00e9dico, presentaci\u00f3n, Vortioxetina 5, Vortioxetina 10, Vortioxetina 20"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "c0bbc515441081827095209e6bf7bcbb7aaed8898c2b875e739b543096639dd9"}, "2": {"node_id": "31dd326c-ab65-4fbc-baa7-2bd9a7365b42", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "0f1aeb691038116e628d30c8c63085f7e8b0ae57d06ef7cea43dde510df0150d"}}, "hash": "f573c9345e08f7bcb835017ad58a31d27b888fd06f2ffd594cba49d979d81690", "text": "medicamento y la cantidad ingerida. Se recomienda llevar el envase y el prospecto del \nmedicamento al profesional sanitario.  \nLos s\u00edntomas en caso de sobredosi s son: mareo postural, n\u00e1useas, diarrea, molestias en el \nest\u00f3mago, picor en todo el cuerpo, somnolencia y rubefacci\u00f3n (enrojecimiento de la piel).  \nTras la ingesta de dosis varias veces superiores a la dosis prescrita, se han notificado episodios \nde convuls iones y S\u00edndrome Serotonin\u00e9rgico.  \nEn caso de sobredosis se deben tratar los s\u00edntomas cl\u00ednicos y someter a una monitorizaci\u00f3n \nadecuada. Se recomienda seguimiento m\u00e9dico en un entorno especializado.  \nPRESENTACI\u00d3N  \nVortioxetina 5: Cajas conteniendo 30 comprimid o recubiertos.  \nVortioxetina 10: Cajas conteniendo 30 comprimido recubiertos.  \nVortioxetina 20: Cajas conteniendo 30 comprimido recubiertos.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "d4e0228c-464f-43ad-9ed6-d3418f4d4db1": {"__data__": {"id_": "d4e0228c-464f-43ad-9ed6-d3418f4d4db1", "embedding": null, "metadata": {"page_label": "7", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What is the recommended storage temperature for the medication Vortioxetine?\n2. Who should be contacted in case of any issues or concerns regarding the use of this medication?\n3. What is the contact information for the National Pharmacovigilance Center in the country where this medication is being used?\n\nHigher-level summary: This context provides information about the precautions and risks associated with the medication Vortioxetine, including the recommended storage temperature, contact information for reporting issues, and the fact that it is a controlled medication requiring a prescription.", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section also mentions the symptoms of an overdose of Vortioxetine and how it should be treated. Additionally, it provides information about the different presentations of Vortioxetine available and the number of tablets included in each package. The entities mentioned in this section include Vortioxetine, overdose symptoms, treatment, precautions, contraindications, and different presentations of the medication.", "section_summary": "The key topics of this section are the recommended storage temperature for the medication Vortioxetine, contact information for reporting issues or concerns about the medication, and the fact that it is a controlled medication requiring a prescription. The key entities mentioned are the National Pharmacovigilance Center and the pharmaceutical company Laboratorio Pharma.IA.", "excerpt_keywords": "producto medicinal, ni\u00f1os, temperatura ambiente, inconveniente, uso, centro nacional de farmacovigilancia, medicamento, t\u00f3xico, intoxicaci\u00f3n, centro de atenci\u00f3n, industria argentina, venta bajo receta profesional, medicamento controlado, titular en pa\u00eds, fabricante, laboratorio Pharma.IA, comercializado, distribuci\u00f3n exclusiva."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "61dd0b1f-4552-4592-b7c3-e182a8b4cac7", "node_type": null, "metadata": {"page_label": "7", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "64e133b07aac3d6c7321f74ebcc575c95f3c9c1dd245229e13338b5e4050f6f8"}}, "hash": "508b32e9f12df252954801dd1ac6110b47a2d8ccf0266284faa1a47ba584425a", "text": "PRODUCTO MEDICINAL  \nMANT\u00c9NGASE FUERA DEL ALCANCE DE LOS NI\u00d1OS CONSERVAR A TEMPERATURA AMBIENTE \nINFERIOR A 30 \u00b0C \nEn caso de inconveniente con el uso de este producto comun\u00edquese con el Centro Nacional de \nFarmacovigilancia de su pa\u00eds.  \nNota:  Todo medicamento es potencialmente t\u00f3xico. En caso de intoxicaci\u00f3n llamar al  centro \nde atenci\u00f3n    \n                                             . \nIndustria Argenti na \nVenta bajo receta profesional MEDICAMENTO CONTROLADO Titular en Pa\u00eds y Fabricante: Laboratorio Pharma.IA ., \nComercializado y distribuci\u00f3n exclusiva laboratorio Pharma.IA", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}}, "docstore/ref_doc_info": {"522ac278-4954-44be-bf8c-ffca1be2f1bc": {"node_ids": ["38581f5e-de4f-43d9-9051-bec1e0402c29", "89cfbb89-9985-4563-8e0a-c30b7816aa39"], "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the different dosages available for Vortioxetine and what is the active ingredient in each dosage?\n2. What is the purpose of Vortioxetine and what condition does it treat in adults?\n3. What precautions should be taken before starting to take Vortioxetine and when should this medication not be taken?", "section_summary": "This section provides information about the medication Vortioxetine, including its dosages, active ingredient, purpose, and precautions. The dosages available for Vortioxetine are 5mg, 10mg, and 20mg, with the active ingredient being Vortioxetine bromhydrate. Vortioxetine is used to treat major depression in adults. Before starting to take Vortioxetine, it is important to consider certain precautions and avoid taking the medication under certain circumstances.", "excerpt_keywords": "Vortioxetina, medicamento, prospecto, informaci\u00f3n, usuario, v\u00eda oral, comprimidos recubiertos, vigilancia adicional, tratamiento, recetado, personas, s\u00edntomas, duda, efecto adverso, m\u00e9dico, f\u00f3rmulas, bromhidrato, principio activo, antidepresivos, episodios, depresi\u00f3n mayor, adultos, tomar."}}, "ab6c173a-3c51-4192-9a95-f624b18c7e99": {"node_ids": ["ddf203a9-df29-440d-900f-c84c894e57a1", "92d383e2-5a2e-43f1-a706-3568521bc0ca", "4be18c04-0d07-4a88-bc0c-339e92743fbd", "b913cbf2-eb53-4ead-bf7e-950de6c142da"], "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment?\n2. How should Vortioxetine be used with caution in patients with a history of seizures or unstable epilepsy?\n3. What precautions should be taken when using Vortioxetine in patients with a history of mania or hypomania?", "prev_section_summary": "This section provides important information about Vortioxetine, including precautions, contraindications, and risks associated with its use for treating major depression in adults. The section mentions that Vortioxetine is an antidepressant medication and should not be taken by individuals who are allergic to Vortioxetine or any of its components, or who are taking certain other medications such as non-selective monoamine oxidase inhibitors (MAOIs) or selective MAO-A inhibitors. It also advises caution when taking Vortioxetine in combination with medications that affect serotonin metabolism, serotoninergic active substances, antipsychotics, and other dopaminergic antagonists, as this may increase the risk of serotonin syndrome (SS) or neuroleptic malignant syndrome (SNM). The symptoms of SS are not mentioned in the provided excerpt.", "section_summary": "The key topics of this section are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment, the caution needed when using Vortioxetine in patients with a history of seizures or unstable epilepsy, and the precautions to be taken when using Vortioxetine in patients with a history of mania or hypomania. The entities mentioned include changes in consciousness, autonomic instability, neuromuscular alterations, gastrointestinal symptoms, seizures, mania, and bleeding tendencies.", "excerpt_keywords": "cambios en el nivel de conciencia, agitaci\u00f3n, alucinaciones, estados de coma, inestabilidad aut\u00f3noma, taquicardia, presi\u00f3n arterial l\u00e1bil, hipertermia, alteraciones neuromusculares, hiperreflexia, descoordinaci\u00f3n, s\u00edntomas gastrointestinales, n\u00e1useas, v\u00f3mitos, diarrea, convulsiones, man\u00eda, tendencia a sangrar, hematomas f\u00e1cilmente."}}, "95710e24-7556-4ff3-b2b7-063b5ae2456c": {"node_ids": ["260e388b-8c94-4b17-b39e-5b122bbe644f", "ea7cff7b-7b84-49ce-8056-88d34c67e2ea", "02c8e2f2-b066-4566-a57e-185c910672a5", "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d"], "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and side effects of using Vortioxetine during pregnancy?\n2. What symptoms may be observed in a newborn if the mother takes Vortioxetine during the last 3 months of pregnancy?\n3. What should a pregnant woman do if her baby exhibits any of the mentioned symptoms after birth?", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. It also mentions that Vortioxetine is not recommended for children and adolescents under 18 years old due to a lack of information in this age group. Additionally, it provides information about the use of Vortioxetine during pregnancy and breastfeeding.", "section_summary": "The key topics of this section are the potential risks and side effects of using Vortioxetine during pregnancy. It mentions that Vortioxetine should not be used during pregnancy unless absolutely necessary, and if the benefits outweigh the possible risks to the fetus. It also states that if Vortioxetine is taken during the last 3 months of pregnancy, certain effects may be observed in the newborn, such as breathing problems, blue skin, seizures, and difficulty feeding. The section advises pregnant women to contact their doctor immediately if their baby exhibits any of these symptoms after birth. The key entities mentioned in this section are Vortioxetine, pregnancy, newborn, and the potential symptoms in the baby.", "excerpt_keywords": "embarazo, lactancia, m\u00e9dico, vortioxetina, riesgo, feto, reci\u00e9n nacido, problemas respiratorios, piel azulada, convulsiones, dificultad de alimentaci\u00f3n, v\u00f3mitos, az\u00facar bajo en sangre, m\u00fasculos r\u00edgidos, reflejos intensos, temblor, irritabilidad, letargia, somnolencia, dificultades para dormir, hipertensi\u00f3n."}}, "7ed4e3fc-7410-4f6a-9799-9007ecb456bc": {"node_ids": ["1895eefa-e41f-40f0-88a5-dc52f54f61a2", "f1e2a382-4ccd-4a49-9eb6-36482b21e060", "9452c1be-1edb-456a-a85a-43cb62f83b4e", "9b2d3a5b-c571-40fe-9202-26acd06c2564"], "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and precautions associated with combining Vortioxetine with irreversible and selective MAO-B inhibitors?\n2. Can the concurrent use of Vortioxetine and medications with serotoninergic effects, such as tramadol or sumatriptan, lead to serotonin syndrome?\n3. How does the use of Vortioxetine in combination with medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs, affect the risk of seizures?", "prev_section_summary": "The key topics of this section are the contraindications and precautions for combining Vortioxetine with certain medications. The section specifically mentions the contraindication of combining Vortioxetine with a weak non-selective reversible MAOI like linezolid. It also discusses the precautions that should be taken when combining Vortioxetine with a reversible and selective MAO-A inhibitor like moclobemide. Additionally, the section mentions the recommended dosage and monitoring approach when combining Vortioxetine with an additional medication. The entities mentioned in this section include Vortioxetine, linezolid, moclobemide, and MAO-A.", "section_summary": "The section discusses the potential risks and precautions associated with combining Vortioxetine with certain medications. The key topics include the combination of Vortioxetine with irreversible and selective MAO-B inhibitors, medications with serotoninergic effects, such as tramadol or sumatriptan, and medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs. The section also mentions the contraindication of combining Vortioxetine with St. John's Wort. The key entities mentioned are Vortioxetine, irreversible and selective MAO-B inhibitors, tramadol, sumatriptan, St. John's Wort, tricyclic antidepressants, and SSRIs.", "excerpt_keywords": "depresi\u00f3n, contraindicaci\u00f3n, combinaci\u00f3n, dosis m\u00ednima, monitorizaci\u00f3n cl\u00ednica, SS, inhibidores de la MAO-B, selegilina, rasagilina, enfermedad de Parkinson, precauci\u00f3n, medicamentos serotonin\u00e9rgicos, tramadol, sumatript\u00e1n, -tript\u00e1n, migra\u00f1a, Hierba de San Juan, Hypericum perforatum, reacciones adversas, umbral convulsivo, antidepresivos tric\u00edclicos, ISRS, IRSN."}}, "d69ca6ed-f926-4841-a592-7fc400f9002f": {"node_ids": ["f0c7c151-f604-4ab6-b62d-fb97e74e7ee4", "c44684d7-a3f9-4d0e-a0bf-539a90eb853b", "04bfad7a-0c57-4de6-bd62-1ddf54451460"], "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the possible side effects of taking Vortioxetine and when do they typically occur?\n2. Can Vortioxetine be taken with alcohol?\n3. What are the precautions and contraindications for using Vortioxetine to treat major depression in adults?", "prev_section_summary": "The section discusses the precautions and risks associated with combining Vortioxetine with the oral contraceptive pill containing ethinyl estradiol and levonorgestrel. It also mentions the cautious use of Vortioxetine when taken together with lithium and tryptophan, medications used to treat depression and mental disorders. Additionally, there is information regarding the administration of Vortioxetine with food and beverages.", "section_summary": "The section discusses the precautions, contraindications, and possible side effects of taking Vortioxetine, a medication used to treat major depression in adults. It mentions that the tablets can be taken with or without food, but it is not recommended to combine the medication with alcohol. The possible side effects are generally mild or moderate and occur within the first two weeks of treatment. Some of the common side effects include nausea, diarrhea, constipation, vomiting, dizziness, itching, abnormal dreams, and flushing of the skin. It also mentions that low levels of sodium in the blood may occur, which can cause symptoms such as dizziness and weakness.", "excerpt_keywords": "Vortioxetina, comprimidos, alimentos, combinaci\u00f3n, alcohol, efectos adversos, n\u00e1useas, diarrea, estre\u00f1imiento, v\u00f3mitos, mareo, prurito, picor, sue\u00f1os anormales, rubefacci\u00f3n, enrojecimiento de la piel, sudores nocturnos, niveles bajos de sodio en sangre, sensaci\u00f3n de mareo, debilidad."}}, "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3": {"node_ids": ["3dadae44-9de5-46c3-8b83-46f87c49d1c8", "31dd326c-ab65-4fbc-baa7-2bd9a7365b42", "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e"], "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when treating patients with renal or hepatic insufficiency with Vortioxetine?\n2. How should the dosage of Vortioxetine be adjusted when combined with potent inhibitors or inducers of the cytochrome P450 enzyme?\n3. How long should Vortioxetine be taken and for how long after feeling better should the treatment continue?", "prev_section_summary": "The key topics of this section are the recommended dosages of Vortioxetine for adults under 65 years old and for elderly patients, precautions and contraindications for taking Vortioxetine in patients over 50 years old, and potential side effects of Vortioxetine. The key entities mentioned are Vortioxetine, adults under 65 years old, elderly patients, and patients over 50 years old.", "section_summary": "The key topics of this section are precautions and risks associated with the use of Vortioxetine in patients with renal or hepatic insufficiency, dosage adjustment when combined with potent inhibitors or inducers of the cytochrome P450 enzyme, and the recommended duration of treatment. The entities mentioned include Vortioxetine, renal or hepatic insufficiency, inhibitors of the cytochrome P450 enzyme, and inducers of the cytochrome P450 enzyme.", "excerpt_keywords": "ajuste de dosis, funci\u00f3n renal, funci\u00f3n hep\u00e1tica, insuficiencia renal, insuficiencia hep\u00e1tica, precauci\u00f3n, inhibidores del citocromo P450, dosis m\u00e1s baja, inhibidor potente, inductores del citocromo P450, ajuste de dosis, duraci\u00f3n del tratamiento, m\u00e9dico, mejor\u00eda, olvido, Vortioxetina."}}, "61dd0b1f-4552-4592-b7c3-e182a8b4cac7": {"node_ids": ["d4e0228c-464f-43ad-9ed6-d3418f4d4db1"], "metadata": {"page_label": "7", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What is the recommended storage temperature for the medication Vortioxetine?\n2. Who should be contacted in case of any issues or concerns regarding the use of this medication?\n3. What is the contact information for the National Pharmacovigilance Center in the country where this medication is being used?\n\nHigher-level summary: This context provides information about the precautions and risks associated with the medication Vortioxetine, including the recommended storage temperature, contact information for reporting issues, and the fact that it is a controlled medication requiring a prescription.", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section also mentions the symptoms of an overdose of Vortioxetine and how it should be treated. Additionally, it provides information about the different presentations of Vortioxetine available and the number of tablets included in each package. The entities mentioned in this section include Vortioxetine, overdose symptoms, treatment, precautions, contraindications, and different presentations of the medication.", "section_summary": "The key topics of this section are the recommended storage temperature for the medication Vortioxetine, contact information for reporting issues or concerns about the medication, and the fact that it is a controlled medication requiring a prescription. The key entities mentioned are the National Pharmacovigilance Center and the pharmaceutical company Laboratorio Pharma.IA.", "excerpt_keywords": "producto medicinal, ni\u00f1os, temperatura ambiente, inconveniente, uso, centro nacional de farmacovigilancia, medicamento, t\u00f3xico, intoxicaci\u00f3n, centro de atenci\u00f3n, industria argentina, venta bajo receta profesional, medicamento controlado, titular en pa\u00eds, fabricante, laboratorio Pharma.IA, comercializado, distribuci\u00f3n exclusiva."}}}, "docstore/metadata": {"38581f5e-de4f-43d9-9051-bec1e0402c29": {"doc_hash": "c496fade0ab667bf370e31b8ad9afa38de9a0950936e88bc42b15a8a6ff76a5d", "ref_doc_id": "522ac278-4954-44be-bf8c-ffca1be2f1bc"}, "89cfbb89-9985-4563-8e0a-c30b7816aa39": {"doc_hash": "eadf913a5dd2a8113d26a409e651e8c7cebe9cf242488f3e87399389dcd5aa5d", "ref_doc_id": "522ac278-4954-44be-bf8c-ffca1be2f1bc"}, "ddf203a9-df29-440d-900f-c84c894e57a1": {"doc_hash": "e674c968deacc17d5cdc75f5fb553efb7b983f56c0ed3be3a1eece597b6b6e05", "ref_doc_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99"}, "92d383e2-5a2e-43f1-a706-3568521bc0ca": {"doc_hash": "ab44c8156fce3b4638e0fa1e3a567aa3ee3aed9a1d8ddf95560c59ba69092e23", "ref_doc_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99"}, "4be18c04-0d07-4a88-bc0c-339e92743fbd": {"doc_hash": "de9a4071a5477e335fc1bed3228827b59230f9d012bffaaaec577e39e30498e3", "ref_doc_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99"}, "b913cbf2-eb53-4ead-bf7e-950de6c142da": {"doc_hash": "e2e94726c2436696708d456be65a65c3e7b0be84a02babcab96c2f2c5a8a70d3", "ref_doc_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99"}, "260e388b-8c94-4b17-b39e-5b122bbe644f": {"doc_hash": "0b3af772ddf2bddae91c03cfaf8d8e83a7bb158ac426ae11832faabb14f11d50", "ref_doc_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c"}, "ea7cff7b-7b84-49ce-8056-88d34c67e2ea": {"doc_hash": "cee9353471cf98ec1b1e59fcb4d9a29e77a8c7116922aa51e4eeba6f40a6b633", "ref_doc_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c"}, "02c8e2f2-b066-4566-a57e-185c910672a5": {"doc_hash": "4cf763c0ba356a8ecfb3751bcf13dac137fd3afdf12510ebd96fe1041b417f1c", "ref_doc_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c"}, "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d": {"doc_hash": "3f8fab90b70fad820d86b8270f49d158755cc2bbde327840bbe160e1268e3853", "ref_doc_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c"}, "1895eefa-e41f-40f0-88a5-dc52f54f61a2": {"doc_hash": "6493cd35493399b37d1ea7ec36769be534a2c55fb5c8b27e23edbcf08e9cabdd", "ref_doc_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc"}, "f1e2a382-4ccd-4a49-9eb6-36482b21e060": {"doc_hash": "4c01ae808cf9ba9098431907d512ce70f0cee296fc5c64cb5265cb74c3d4ceeb", "ref_doc_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc"}, "9452c1be-1edb-456a-a85a-43cb62f83b4e": {"doc_hash": "4fc35df3be392d92a23bce5c184a529d65b575c1ef9bf08b19503fb0e2daad20", "ref_doc_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc"}, "9b2d3a5b-c571-40fe-9202-26acd06c2564": {"doc_hash": "668b4645e65ea2ed49e0ff9332f7fa4aea0f2815de6a5585607d5a0d6ffcebba", "ref_doc_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc"}, "f0c7c151-f604-4ab6-b62d-fb97e74e7ee4": {"doc_hash": "ed84bb54a758054a23657e4e2676944504537e1d8962a018494531ec8e6f1f1c", "ref_doc_id": "d69ca6ed-f926-4841-a592-7fc400f9002f"}, "c44684d7-a3f9-4d0e-a0bf-539a90eb853b": {"doc_hash": "e45eeff75717c2d7b5cf0b6036dfc0b00ad01c1967a360a5ff041e712791f643", "ref_doc_id": "d69ca6ed-f926-4841-a592-7fc400f9002f"}, "04bfad7a-0c57-4de6-bd62-1ddf54451460": {"doc_hash": "d998cff15e5aece521f7afc83b0441369edb495869b95d815b9dde7d55f7c2ab", "ref_doc_id": "d69ca6ed-f926-4841-a592-7fc400f9002f"}, "3dadae44-9de5-46c3-8b83-46f87c49d1c8": {"doc_hash": "63819555553cbe1d1f6ec4b4b29545b7c8f46dd5a49943d47b1bfc27ee6a6e70", "ref_doc_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3"}, "31dd326c-ab65-4fbc-baa7-2bd9a7365b42": {"doc_hash": "0f1aeb691038116e628d30c8c63085f7e8b0ae57d06ef7cea43dde510df0150d", "ref_doc_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3"}, "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e": {"doc_hash": "f573c9345e08f7bcb835017ad58a31d27b888fd06f2ffd594cba49d979d81690", "ref_doc_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3"}, "d4e0228c-464f-43ad-9ed6-d3418f4d4db1": {"doc_hash": "508b32e9f12df252954801dd1ac6110b47a2d8ccf0266284faa1a47ba584425a", "ref_doc_id": "61dd0b1f-4552-4592-b7c3-e182a8b4cac7"}}}