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-{"docstore/data": {"c63cf7de-365f-45f9-8a21-51bb0f94cda1": {"__data__": {"id_": "c63cf7de-365f-45f9-8a21-51bb0f94cda1", "embedding": null, "metadata": {"page_label": "1", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin)?\n2. What are the considerations for using Acetilsalic\u00edlico (Aspirin) during surgical procedures, pregnancy, and interactions with other medications?\n3. What is the recommended dosage and administration instructions for Acetilsalic\u00edlico (Aspirin) in oral tablets?", "section_summary": "The section provides information about the prospectus of Acetilsalic\u00edlico (Aspirin), including its precautions and contraindications, considerations for use during surgical procedures, pregnancy, and interactions with other medications. It also mentions the recommended dosage and administration instructions for Acetilsalic\u00edlico in oral tablets. The section emphasizes the importance of reading the prospectus carefully and consulting a healthcare professional for advice or more information. The key topics covered include the use and benefits of Acetilsalic\u00edlico, its classification as a non-steroidal anti-inflammatory drug (NSAID), and its ability to relieve pain and reduce fever. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), the active ingredient, and the potential users of the medication.", "excerpt_keywords": "acetilsalic\u00edlico, 500 mg, v\u00eda oral, comprimidos recubiertos, prospecto, informaci\u00f3n, usuario, medicamento, instrucciones, administraci\u00f3n, m\u00e9dico, farmac\u00e9utico, consejo, efectos adversos, dolor, fiebre, \u00e1cido acetilsalic\u00edlico, antiinflamatorios no esteroideos, alivio sintom\u00e1tico, dolores ocasionales, leves, moderados."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "80135828-8074-43e0-a063-d6b0926b7179", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "3942ac08c209d434d9150e823cc1d0799aaa38a24857c3d2dce8384a135c3173"}, "3": {"node_id": "668cd82f-7472-4059-b196-9e4d723b3996", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "05551e077471d767bc1ca6e2de6e7acca6dea7a289bd79aebac3dc463bfeab10"}}, "hash": "8881d98051aecdb68d661372fb333a7bdfe15a22f887f3de7c7c854e53c999a8", "text": "Prospecto: informaci\u00f3n para el usuario \nAcetilsalic\u00edlico \n500 mg \nV\u00eda oral  - Comprimidos recubiertos \nLEA TODO EL PROSPECTO DETENIDAMENTE ANTES DE EMPEZAR A TOMAR ESTE \nMEDICAMENTO, PORQUE CONTIENE INFORMACI\u00d3N IMPORTANTE PARA USTED. \nSiga exactamente las instrucciones de administraci\u00f3n del medicamento contenidas en este \nprospecto o las indicadas por su m\u00e9dico o farmac\u00e9utico.  \n\u2022 Conserve este prospecto, ya que puede tener que volver a leerlo.  \n\u2022 Si necesita consejo o m\u00e1s informaci\u00f3n, consulte a su farmac\u00e9utico.  \n\u2022 Si experimenta efectos adversos, consulte a su m\u00e9dico o farmac\u00e9utico, incluso si se \ntrata de  \n\u2022 efectos adversos que no aparecen en este prospecto. Ver secci\u00f3n 4.  \n\u2022 Debe consultar a un m\u00e9dico si empeora o si no mejora despu\u00e9s de 5 d\u00edas para el dolor o 3 d\u00edas  \n\u2022 para la fiebre. \n \n1. Qu\u00e9 es Acetilsalic\u00edlico y para qu\u00e9 se utiliza  \nEl \u00e1cido acetilsalic\u00edlico, principio activo de este medicamento, pertenece a un grupo de medicamentos  \nconocidos como medicamentos antiinflamatorios no esteroideos (AINEs). Alivia el dolor y \nreduce la fiebre.  \nEste medicamento se utiliza en el alivio sintom\u00e1tico de los dolores ocasionales leves o \nmoderados, como", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "668cd82f-7472-4059-b196-9e4d723b3996": {"__data__": {"id_": "668cd82f-7472-4059-b196-9e4d723b3996", "embedding": null, "metadata": {"page_label": "1", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin)?\n- This context specifically mentions the precautions and contraindications for using Acetilsalic\u00edlico, providing specific information on who should not take this medication and under what conditions.\n\n2. What are the considerations for using Acetilsalic\u00edlico during surgical procedures, pregnancy, and interactions with other medications?\n- The context mentions that there are considerations for using Acetilsalic\u00edlico during surgical procedures, pregnancy, and interactions with other medications, indicating that specific information regarding these situations can be found in the context.\n\n3. What are the symptoms and conditions that Acetilsalic\u00edlico can be used to treat?\n- The context states that Acetilsalic\u00edlico is used for the relief of occasional mild or moderate pains, such as headaches, dental pain, menstrual pain, muscle pain, and back pain, as well as for reducing fever. This provides specific information on the symptoms and conditions that this medication can be used to treat.", "prev_section_summary": "The section provides information about the prospectus of Acetilsalic\u00edlico (Aspirin), including its precautions and contraindications, considerations for use during surgical procedures, pregnancy, and interactions with other medications. It also mentions the recommended dosage and administration instructions for Acetilsalic\u00edlico in oral tablets. The section emphasizes the importance of reading the prospectus carefully and consulting a healthcare professional for advice or more information. The key topics covered include the use and benefits of Acetilsalic\u00edlico, its classification as a non-steroidal anti-inflammatory drug (NSAID), and its ability to relieve pain and reduce fever. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), the active ingredient, and the potential users of the medication.", "section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin), considerations for using Acetilsalic\u00edlico during surgical procedures, pregnancy, and interactions with other medications, and the symptoms and conditions that Acetilsalic\u00edlico can be used to treat. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), surgical procedures, pregnancy, and other medications.", "excerpt_keywords": "\u00e1cido acetilsalic\u00edlico, medicamento, antiinflamatorios no esteroideos, alivio sintom\u00e1tico, dolores ocasionales, leves, moderados, dolores de cabeza, dentales, menstruales, musculares, contracturas, espalda, lumbalgia, estados febriles, adultos, adolescentes, consultar m\u00e9dico, empeorar, mejorar, alergia, reacci\u00f3n al\u00e9rgica, \u00falcera de est\u00f3mago, intestino, molestias g\u00e1stricas."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "80135828-8074-43e0-a063-d6b0926b7179", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "3942ac08c209d434d9150e823cc1d0799aaa38a24857c3d2dce8384a135c3173"}, "2": {"node_id": "c63cf7de-365f-45f9-8a21-51bb0f94cda1", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "8881d98051aecdb68d661372fb333a7bdfe15a22f887f3de7c7c854e53c999a8"}}, "hash": "05551e077471d767bc1ca6e2de6e7acca6dea7a289bd79aebac3dc463bfeab10", "text": "El \u00e1cido acetilsalic\u00edlico, principio activo de este medicamento, pertenece a un grupo de medicamentos  \nconocidos como medicamentos antiinflamatorios no esteroideos (AINEs). Alivia el dolor y \nreduce la fiebre.  \nEste medicamento se utiliza en el alivio sintom\u00e1tico de los dolores ocasionales leves o \nmoderados, como  \ndolores de cabeza, dentales, menstruales, musculares (contracturas) o de espalda (lumbalgia) y estados \nfebriles en adultos y adolescentes  mayores de 16 a\u00f1os.  \nDebe consultar a un m\u00e9dico si empeora o si no mejora despu\u00e9s de 5 d\u00edas para el dolor o 3 d\u00edas \npara la \nfiebre. 2. Qu\u00e9 necesita saber antes de empezar a tomar Acetilsalic\u00edlico  \nNo tome  Acetilsalic\u00edlico si: \n\uf8e7 es al\u00e9rgico o ha tenido alguna r eacci\u00f3n al\u00e9rgica al \u00e1cido acetilsalic\u00edlico o a cualquier \notro  \n\uf8e7 componente de este medicamento (incluidos en la secci\u00f3n 6),  \n\uf8e7 padece \u00falcera de est\u00f3mago, de intestino o molestias g\u00e1stricas de repetici\u00f3n,", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "c0e01ead-0ea5-4dcc-929e-7a0fcdf817a2": {"__data__": {"id_": "c0e01ead-0ea5-4dcc-929e-7a0fcdf817a2", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) in patients with asthma or allergic reactions to anti-inflammatory drugs?\n2. Can Acetilsalic\u00edlico be used in patients with kidney or liver diseases, hypertension, or blood clotting disorders?\n3. Is it safe to use Acetilsalic\u00edlico during pregnancy, particularly in the third trimester?", "prev_section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin), considerations for using Acetilsalic\u00edlico during surgical procedures, pregnancy, and interactions with other medications, and the symptoms and conditions that Acetilsalic\u00edlico can be used to treat. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), surgical procedures, pregnancy, and other medications.", "section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin). It mentions that patients with asthma or allergic reactions to anti-inflammatory drugs should not take Acetilsalic\u00edlico. It also states that patients with kidney or liver diseases, hypertension, blood clotting disorders, or in their third trimester of pregnancy should use Acetilsalic\u00edlico with caution and consult their doctor. The section also mentions the potential risks of using Acetilsalic\u00edlico in patients under 16 years old, as it has been associated with a rare but serious condition called Reye's syndrome.", "excerpt_keywords": "reacciones al\u00e9rgicas, asm\u00e1tico, dificultad para respirar, ahogo, broncoespasmos, tos, pitidos al respirar, antiinflamatorios, \u00e1cido acetilsalic\u00edlico, analg\u00e9sicos, colorante tartrazina, asma, p\u00f3lipos nasal, hemofilia, coagulaci\u00f3n sangu\u00ednea, medicamentos anticoagulantes orales, enfermedades del ri\u00f1\u00f3n, insuficiencia renal, enfermedades del h\u00edgado, insuficiencia hep\u00e1tica, S\u00edndrome de Reye, tercer trimestre del embarazo, hipertensi\u00f3n arterial, funciones del ri\u00f1\u00f3n, funciones del coraz\u00f3n, funciones del h\u00edgado, alteraciones en la coagulaci\u00f3n sangu\u00ednea."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "9698a130-2127-47db-893f-7992771f3c74", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "d723387a127b0af70bea31d31db93a2e2fc20f853d2d789ebd8e9fd5a0171e04"}, "3": {"node_id": "ad451347-fd33-45d6-a4f6-42616bf1636a", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "451382477c336cf8966fdfd4292323b226cd2b4cbbfd4d34e184ffe3921199f5"}}, "hash": "82cde4e6cf847bd126352b0b6541d3c933fcae82aecd716e25661178a7cce04f", "text": "\uf8e7 ha presentado reacciones al\u00e9rgicas de tipo asm\u00e1tico (dificultad para respirar, ahogo, \nbroncoespasmos y en algunos casos tos o pitidos al respirar) al tomar \nantiinflamatorios, \u00e1cido acetilsalic\u00edlico, otros analg\u00e9sicos, as\u00ed como al colorante \ntartrazina,  \n\uf8e7 padece o ha padecido asma,  \n\uf8e7 padece p\u00f3lipos nasal es asociados a asma que sean producidos o aumentados por el \n\u00e1cido  \n\uf8e7 acetilsalic\u00edlico,  \n\uf8e7 padece hemofilia u otros problemas de coagulaci\u00f3n sangu\u00ednea,  \n\uf8e7 est\u00e1 en tratamiento con medicamentos anticoagulantes orales,  \n\uf8e7 padece enfermedades del ri\u00f1\u00f3n y/o del h\u00edgado (insu ficiencia renal y/o hep\u00e1tica),  \n\uf8e7 tiene menos de 16 a\u00f1os, ya que el uso de \u00e1cido acetilsalic\u00edlico se ha relacionado con el \nS\u00edndrome de Reye, enfermedad poco frecuente pero grave,  \n\uf8e7 se encuentra en su tercer trimestre del embarazo.  \nTenga especial cuidado con Ace tilsalic\u00edlico.  \n Deber\u00e1 consultar con su m\u00e9dico en caso de que requiera este medicamento:  \n\uf8e7 Si padece hipertensi\u00f3n arterial, o tiene reducidas las funciones del ri\u00f1\u00f3n, coraz\u00f3n o \nh\u00edgado, o  \n\uf8e7 presenta alteraciones en la coagulaci\u00f3n sangu\u00ednea,", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "ad451347-fd33-45d6-a4f6-42616bf1636a": {"__data__": {"id_": "ad451347-fd33-45d6-a4f6-42616bf1636a", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin)?\n2. Can Acetilsalic\u00edlico (Aspirin) interact with other medications?\n3. In what situations should Acetilsalic\u00edlico (Aspirin) not be administered, such as during pregnancy or before surgical procedures?", "prev_section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin). It mentions that patients with asthma or allergic reactions to anti-inflammatory drugs should not take Acetilsalic\u00edlico. It also states that patients with kidney or liver diseases, hypertension, blood clotting disorders, or in their third trimester of pregnancy should use Acetilsalic\u00edlico with caution and consult their doctor. The section also mentions the potential risks of using Acetilsalic\u00edlico in patients under 16 years old, as it has been associated with a rare but serious condition called Reye's syndrome.", "section_summary": "The section provides information about the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin). It mentions that individuals with hypertension, kidney, heart, or liver problems, blood clotting disorders, stomach or intestinal ulcers, or those on anticoagulant treatment should consult their doctor before taking this medication. It also warns about potential interactions with other medications and advises against its use in individuals allergic to other anti-inflammatory drugs or with glucose-6-phosphate dehydrogenase deficiency. The section further states that Acetilsalic\u00edlico should not be taken by individuals with a history of rhinitis or urticaria, those who have recently undergone or will undergo surgery in the next 7 days, or those in the first or second trimester of pregnancy. It also advises against using it as a preventive measure for vaccination-related discomfort.", "excerpt_keywords": "Ace tilsalic\u00edlico, hipertensi\u00f3n arterial, ri\u00f1\u00f3n, coraz\u00f3n, h\u00edgado, coagulaci\u00f3n sangu\u00ednea, \u00falcera de est\u00f3mago, intestino, anticoagulantes, antiinflamatorios, interacci\u00f3n, al\u00e9rgico, glucosa-6-fosfato deshidrogenasa, rinitis, urticaria, intervenci\u00f3n quir\u00fargica, embarazo, vacunaciones"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "9698a130-2127-47db-893f-7992771f3c74", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "d723387a127b0af70bea31d31db93a2e2fc20f853d2d789ebd8e9fd5a0171e04"}, "2": {"node_id": "c0e01ead-0ea5-4dcc-929e-7a0fcdf817a2", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "82cde4e6cf847bd126352b0b6541d3c933fcae82aecd716e25661178a7cce04f"}, "3": {"node_id": "12f9f651-f553-4b67-8ac7-3788383d27b7", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "a8ebfa20e2570f063fd546db9d3a58fcd6d54dbee88909361ca7c2bb4963f883"}}, "hash": "451382477c336cf8966fdfd4292323b226cd2b4cbbfd4d34e184ffe3921199f5", "text": "Tenga especial cuidado con Ace tilsalic\u00edlico.  \n Deber\u00e1 consultar con su m\u00e9dico en caso de que requiera este medicamento:  \n\uf8e7 Si padece hipertensi\u00f3n arterial, o tiene reducidas las funciones del ri\u00f1\u00f3n, coraz\u00f3n o \nh\u00edgado, o  \n\uf8e7 presenta alteraciones en la coagulaci\u00f3n sangu\u00ednea,  \n\uf8e7 si ha padecido \u00falcer a de est\u00f3mago o intestino,  \n\uf8e7 si est\u00e1 en tratamiento con anticoagulantes deber\u00e1 consultar con su m\u00e9dico antes de tomar este medicamento,  \n\uf8e7 si est\u00e1 tomando antiinflamatorios u otro tipo de medicamentos ya que ciertos medicamentos  \n\uf8e7 pueden interaccionar con Acetils alic\u00edlico 500 mg comprimidos y producir efectos \nindeseables (ver apartado \u201cUso de otros medicamentos\u201d),  \n\uf8e7 si es al\u00e9rgico a otros antiinflamatorios o antirreum\u00e1ticos,  \n\uf8e7 si tiene una deficiencia de glucosa -6-fosfato deshidrogenasa,  \n\uf8e7 si padece o ha padecido riniti s o urticaria,  \n\uf8e7 si se ha sometido recientemente o si debe someterse en los pr\u00f3ximos 7 d\u00edas a una \nintervenci\u00f3n quir\u00fargica, incluyendo cirug\u00eda dental,  \n\uf8e7 si se encuentra en el primer o segundo trimestre del embarazo,  \n\uf8e7 no administrar sistem\u00e1ticamente para prevenir  las posibles molestias originadas por \nlas vacunaciones.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "12f9f651-f553-4b67-8ac7-3788383d27b7": {"__data__": {"id_": "12f9f651-f553-4b67-8ac7-3788383d27b7", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) before undergoing surgical procedures?\n2. Can Acetilsalic\u00edlico be safely used during the first and second trimester of pregnancy?\n3. Are there any potential interactions between Acetilsalic\u00edlico and other medications, including over-the-counter drugs, homeopathic remedies, and herbal supplements?", "prev_section_summary": "The section provides information about the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin). It mentions that individuals with hypertension, kidney, heart, or liver problems, blood clotting disorders, stomach or intestinal ulcers, or those on anticoagulant treatment should consult their doctor before taking this medication. It also warns about potential interactions with other medications and advises against its use in individuals allergic to other anti-inflammatory drugs or with glucose-6-phosphate dehydrogenase deficiency. The section further states that Acetilsalic\u00edlico should not be taken by individuals with a history of rhinitis or urticaria, those who have recently undergone or will undergo surgery in the next 7 days, or those in the first or second trimester of pregnancy. It also advises against using it as a preventive measure for vaccination-related discomfort.", "section_summary": "The section provides information about the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) before undergoing surgical procedures, its safety during the first and second trimester of pregnancy, and potential interactions with other medications. It advises against using Acetilsalic\u00edlico before surgery, during early pregnancy, and for preventing discomfort from vaccinations. It also mentions the importance of informing healthcare professionals about other medications, including over-the-counter drugs, homeopathic remedies, and herbal supplements, as they may require adjustments or discontinuation of treatment. Additionally, it highlights the potential interactions with other analgesics or non-steroidal anti-inflammatory drugs.", "excerpt_keywords": "intervenci\u00f3n quir\u00fargica, cirug\u00eda dental, embarazo, molestias, vacunaciones, medicamentos, acetilsalic\u00edlico, m\u00e9dico, farmac\u00e9utico, receta m\u00e9dica, homeop\u00e1ticos, plantas medicinales, salud, analg\u00e9sicos, antiinflamatorios, dolor, inflamaci\u00f3n muscular"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "9698a130-2127-47db-893f-7992771f3c74", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "d723387a127b0af70bea31d31db93a2e2fc20f853d2d789ebd8e9fd5a0171e04"}, "2": {"node_id": "ad451347-fd33-45d6-a4f6-42616bf1636a", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "451382477c336cf8966fdfd4292323b226cd2b4cbbfd4d34e184ffe3921199f5"}}, "hash": "a8ebfa20e2570f063fd546db9d3a58fcd6d54dbee88909361ca7c2bb4963f883", "text": "\uf8e7 si se ha sometido recientemente o si debe someterse en los pr\u00f3ximos 7 d\u00edas a una \nintervenci\u00f3n quir\u00fargica, incluyendo cirug\u00eda dental,  \n\uf8e7 si se encuentra en el primer o segundo trimestre del embarazo,  \n\uf8e7 no administrar sistem\u00e1ticamente para prevenir  las posibles molestias originadas por \nlas vacunaciones.  \nOtros medicamentos y Acetilsalic\u00edlico  \nInforme a su m\u00e9dico o farmac\u00e9utico si est\u00e1 utilizando o ha utilizado recientemente otros \nmedicamentos  incluso los adquiridos sin receta m\u00e9dica, homeop\u00e1ticos, plantas medicinales y \notros productos relacionados  con la salud ya que puede ser necesario interrumpir el \ntratamiento o ajustar la dosis de alguno de ellos.  \nEsto es especialmente importante en el caso de:  \n- otros analg\u00e9sicos o antiinflamatori os no esteroideos (medicamentos que se utilizan para \ntratar el dolor  \ny/o inflamaci\u00f3n muscular),", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "ed8eb388-de37-4edb-aa86-3588e5536406": {"__data__": {"id_": "ed8eb388-de37-4edb-aa86-3588e5536406", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the potential drug interactions and contraindications for Acetilsalic\u00edlico (Aspirin) use?\n- The context provides a list of medications that may interact with Acetilsalic\u00edlico, such as anticoagulants, antidiabetic drugs, barbiturates, betablockers, and more.\n\n2. What are the precautions and considerations for using Acetilsalic\u00edlico (Aspirin) during surgical procedures and pregnancy?\n- The context mentions considerations for medication use during surgical procedures and pregnancy, indicating that there may be specific precautions or risks associated with using Acetilsalic\u00edlico in these situations.\n\n3. What are the potential risks and contraindications of using Acetilsalic\u00edlico (Aspirin) for individuals with certain medical conditions?\n- The context mentions specific medical conditions, such as high blood pressure, epilepsy, cancer, and arthritis, and suggests that Acetilsalic\u00edlico may have contraindications or risks for individuals with these conditions.", "prev_section_summary": "The section provides information about the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) before undergoing surgical procedures, its safety during the first and second trimester of pregnancy, and potential interactions with other medications. It advises against using Acetilsalic\u00edlico before surgery, during early pregnancy, and for preventing discomfort from vaccinations. It also mentions the importance of informing healthcare professionals about other medications, including over-the-counter drugs, homeopathic remedies, and herbal supplements, as they may require adjustments or discontinuation of treatment. Additionally, it highlights the potential interactions with other analgesics or non-steroidal anti-inflammatory drugs.", "section_summary": "The key topics of this section are the potential drug interactions and contraindications for Acetilsalic\u00edlico (Aspirin) use, the precautions and considerations for using Acetilsalic\u00edlico during surgical procedures and pregnancy, and the potential risks and contraindications of using Acetilsalic\u00edlico for individuals with certain medical conditions. The entities mentioned include specific medications that may interact with Acetilsalic\u00edlico, such as anticoagulants, antidiabetic drugs, barbiturates, betablockers, and more. Medical conditions such as high blood pressure, epilepsy, cancer, and arthritis are also mentioned.", "excerpt_keywords": "antidepresivos, inhibidores selectivos de la recaptaci\u00f3n de serotonina, hemorragia, anticoagulantes, warfarina, antidiab\u00e9ticos orales, barbit\u00faricos, convulsiones, betabloqueantes, cimetidina, ranitidina, ciclosporina, tacrolimus, corticoides, hemorragia digestiva, digoxina, presi\u00f3n arterial alta, diur\u00e9ticos, inhibidores de ECA, fenito\u00edna, \u00e1cido valproico, antiepil\u00e9pticos, interfer\u00f3n alfa, infecciones v\u00edricas, tumorales, litio, enfermedad psiqui\u00e1trica, c\u00e1ncer, artritis reumatoide, metotrexato, gota, probenecid."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "584f8311-4757-4ffb-9338-094200dd2e7e", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "9e057dd32469f701f6fcb044f1edcd3c74b07e4462f3738600ec5f57bddc28a9"}, "3": {"node_id": "0a33b138-c6b5-4c8d-8f40-c5808ed86b4a", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "69fb74d9a060108038571d36e42294c5aa0c8027dba165f9660c18ec2ae89ec4"}}, "hash": "2887cc0d332a4b29dadc6055bdf801a5bdcb63bc28c9487e34f8f2f5cade43d1", "text": "- algunos antidepresivos, como los inhibidores selectivos de la recaptaci\u00f3n de serotonina, ya \nque \naumenta el riesgo de hemorragia,  \n- anticoagulantes (medicament os que se utilizan para \u201cfluidificar\u201d la sangre y evitar la aparici\u00f3n \nde \nco\u00e1gulos) como warfarina,  \n- antidiab\u00e9ticos orales (medicamentos para disminuir el nivel de az\u00facar en sangre),  \n- barbit\u00faricos (medicamentos utilizados para el tratamiento de las convul siones),  \n- betabloqueantes (medicamentos para el control de la hipertensi\u00f3n),  \n- cimetidina y ranitidina (utilizados para la acidez de est\u00f3mago),  \n- medicamentos utilizados para evitar el rechazo de los transplantes (ciclosporina y \ntacrolimus),  \n- corticoides , ya que puede potenciar el riesgo de hemorragia digestiva,  \n- digoxina (medicamento para el coraz\u00f3n),  \n- presi\u00f3n arterial alta (diur\u00e9ticos e inhibidores de ECA),  \n- fenito\u00edna y \u00e1cido valproico (antiepil\u00e9pticos),  \n- interfer\u00f3n alfa (utilizado para el tratamiento de ciertas infecciones v\u00edricas y tumorales),  \n- litio (utilizado en alguna enfermedad psiqui\u00e1trica),  \n- c\u00e1ncer o artritis reumatoide (metotrexato),  \n- medicamentos utilizados para el tratamiento de la gota (probenecid),", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "0a33b138-c6b5-4c8d-8f40-c5808ed86b4a": {"__data__": {"id_": "0a33b138-c6b5-4c8d-8f40-c5808ed86b4a", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin)?\n- The context mentions \"Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use\" and \"Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico.\" This suggests that the context can provide specific information about the precautions and contraindications for using Acetilsalic\u00edlico.\n\n2. What medications can interact with Acetilsalic\u00edlico?\n- The context lists several medications, such as interfer\u00f3n alfa, litio, metotrexato, probenecid, vancomicina, and zidovudina, which can potentially interact with Acetilsalic\u00edlico. This indicates that the context can provide specific information about the medications that can interact with Acetilsalic\u00edlico.\n\n3. How does Acetilsalic\u00edlico interact with alcohol?\n- The context mentions that taking Acetilsalic\u00edlico while consuming alcohol can lead to stomach bleeding. This suggests that the context can provide specific information about the interaction between Acetilsalic\u00edlico and alcohol.", "prev_section_summary": "The key topics of this section are the potential drug interactions and contraindications for Acetilsalic\u00edlico (Aspirin) use, the precautions and considerations for using Acetilsalic\u00edlico during surgical procedures and pregnancy, and the potential risks and contraindications of using Acetilsalic\u00edlico for individuals with certain medical conditions. The entities mentioned include specific medications that may interact with Acetilsalic\u00edlico, such as anticoagulants, antidiabetic drugs, barbiturates, betablockers, and more. Medical conditions such as high blood pressure, epilepsy, cancer, and arthritis are also mentioned.", "section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin), the medications that can interact with Acetilsalic\u00edlico, and the interaction between Acetilsalic\u00edlico and alcohol. The entities mentioned include interfer\u00f3n alfa, litio, metotrexato, probenecid, vancomicina, zidovudina, and alcohol.", "excerpt_keywords": "interfer\u00f3n alfa, litio, c\u00e1ncer, artritis reumatoide, metotrexato, gota, probenecid, vancomicina, zidovudina, infecciones, virus, tumorales, enfermedad psiqui\u00e1trica, SIDA, pruebas de diagn\u00f3stico, an\u00e1lisis de sangre, an\u00e1lisis de orina, alimentos, bebidas, alcohol, hemorragia de est\u00f3mago, embarazo."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "584f8311-4757-4ffb-9338-094200dd2e7e", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "9e057dd32469f701f6fcb044f1edcd3c74b07e4462f3738600ec5f57bddc28a9"}, "2": {"node_id": "ed8eb388-de37-4edb-aa86-3588e5536406", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "2887cc0d332a4b29dadc6055bdf801a5bdcb63bc28c9487e34f8f2f5cade43d1"}}, "hash": "69fb74d9a060108038571d36e42294c5aa0c8027dba165f9660c18ec2ae89ec4", "text": "- interfer\u00f3n alfa (utilizado para el tratamiento de ciertas infecciones v\u00edricas y tumorales),  \n- litio (utilizado en alguna enfermedad psiqui\u00e1trica),  \n- c\u00e1ncer o artritis reumatoide (metotrexato),  \n- medicamentos utilizados para el tratamiento de la gota (probenecid),  \n- vancomicina (antibi\u00f3tico utilizado  para las infecciones),  \n- zidovudina (utilizada en el tratamiento de los pacientes infectados por el virus de la \ninmunodeficiencia  humana, causante del SIDA).  \nInterferencias con pruebas de diagn\u00f3stico  \nSi le van a hacer alguna prueba diagn\u00f3stica (incluidos an\u00e1lisis de sangre, orina, etc\u2026), informe \na su m\u00e9dico  que est\u00e1 tomando este medicamento, ya que puede alterar los resultados.  \nToma de Acetilsalic\u00edlico con alimentos, bebidas y alcohol  \nTome este medicamento despu\u00e9s de las comidas o con alg\u00fan alimento.  \nSi us ted consume habitualmente alcohol (tres o m\u00e1s bebidas alcoh\u00f3licas \u2013 cerveza, vino, licor),  \ntomar Acetilsalic\u00edlico le puede provocar una hemorragia de est\u00f3mago.  \nConsulte a su m\u00e9dico o farmac\u00e9utico antes de utilizar cualquier medicamento.  \nIMPORTANTE PARA LA MUJER:  \nEmbarazo", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "2d17947a-41ce-48f6-a53f-baaa463dd60d": {"__data__": {"id_": "2d17947a-41ce-48f6-a53f-baaa463dd60d", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) during pregnancy?\n- This context specifically mentions that the consumption of Acetilsalic\u00edlico during the first and second trimester of pregnancy can be dangerous for the embryo or fetus and should be monitored by a doctor. It also advises against taking the medication during the third trimester as it may prolong labor and contribute to bleeding for both the mother and baby.\n\n2. Should women who are breastfeeding consult a doctor before using Acetilsalic\u00edlico?\n- Yes, according to the context, women who are breastfeeding should consult a doctor or pharmacist before using this medication as Acetilsalic\u00edlico can pass into breast milk.\n\n3. Is there an age restriction for the use of Acetilsalic\u00edlico?\n- Yes, the context states that Acetilsalic\u00edlico should not be administered to children under the age of 16.", "prev_section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin), the medications that can interact with Acetilsalic\u00edlico, and the interaction between Acetilsalic\u00edlico and alcohol. The entities mentioned include interfer\u00f3n alfa, litio, metotrexato, probenecid, vancomicina, zidovudina, and alcohol.", "section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) during pregnancy, the need for consultation with a doctor before using Acetilsalic\u00edlico while breastfeeding, the age restriction for the use of Acetilsalic\u00edlico in children under 16, and the consideration for older adults to consult a doctor before taking the medication. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), pregnancy, breastfeeding, children, and older adults.", "excerpt_keywords": "embarazo, medicamento, peligroso, embri\u00f3n, feto, vigilado, tercer trimestre, prolongar, parto, sangrado, lactancia, \u00e1cido acetilsalic\u00edlico, leche materna, ni\u00f1os, menores de 16 a\u00f1os, mayores de 65 a\u00f1os, efectos adversos, conducci\u00f3n, m\u00e1quinas, instrucciones, prospecto, duda, m\u00e9dico, farmac\u00e9utico."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "0157b6a2-6481-4e44-9e0a-c7b6f7c8aee8", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "c98dcf55aac64e4a520c12db6feafd967395f14c05ce3030f9e3cb7682511ce6"}, "3": {"node_id": "1253b748-c5c7-42b5-b518-184ac58e306b", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "f263a30bcc273d49b1eb022a4f49d1e01e6bc3fc5bdfa842ad0ed2c7d6248e0c"}}, "hash": "d0d495c1ad30bdc93c7b6ae15c936e64b1c170b95809e238fc7f2f5cfd772a87", "text": "Si est\u00e1 usted embarazada o cree que pudiera estarlo, consulte a su m\u00e9dico antes de tomar este  \nmedicamento. El consumo de este medicamento durante el primer y segundo trimestre del \nembarazo  puede ser peligroso para el embri\u00f3n o el feto y debe ser vigilado por su m\u00e9dico. No \ntome este  medicamento durante el tercer trimestre de embarazo, ya que puede prolongar el \nparto y contribuir  al sangrado de la madre o del beb\u00e9. \nLactancia  \nConsulte a su m\u00e9dico o farmac\u00e9utico antes de utilizar cualquier medic amento.  Las mujeres en \nperiodo de lactancia deben consultar al m\u00e9dico antes de utilizar este medicamento, ya que el \u00e1cido acetilsalic\u00edlico pasa a la leche materna.  \nUso en ni\u00f1os  \nNo administrar a menores de 16 a\u00f1os.  \nUso en mayores de 65 a\u00f1os  \nLas personas de edad avanzada no deben tomar este medicamento sin consultar a su m\u00e9dico, \nya que son  m\u00e1s propensas a padecer sus efectos adversos.  \nConducci\u00f3n y uso de m\u00e1quinas  \nNo se ha descrito ning\u00fan efecto sobre la capacidad para conducir o utilizar m\u00e1quinas. \n3. C\u00f3mo tomar Acetilsalic\u00edlico  \nSiga exactamente las instrucciones de administraci\u00f3n del medicamento contenidas en este \nprospecto o las  indicadas por su m\u00e9dico o farmac\u00e9utico. En caso de duda, pregunte a su \nm\u00e9dico o farmac\u00e9utico.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "1253b748-c5c7-42b5-b518-184ac58e306b": {"__data__": {"id_": "1253b748-c5c7-42b5-b518-184ac58e306b", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What is the recommended dosage of Acetilsalic\u00edlico (Aspirin) for adults and adolescents over 16 years old?\n2. Can Acetilsalic\u00edlico (Aspirin) be taken on an empty stomach?\n3. How long should Acetilsalic\u00edlico (Aspirin) be taken for pain relief or fever reduction before considering discontinuation?", "prev_section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) during pregnancy, the need for consultation with a doctor before using Acetilsalic\u00edlico while breastfeeding, the age restriction for the use of Acetilsalic\u00edlico in children under 16, and the consideration for older adults to consult a doctor before taking the medication. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), pregnancy, breastfeeding, children, and older adults.", "section_summary": "The section provides information about the usage and precautions of Acetilsalic\u00edlico (Aspirin). It includes the recommended dosage for adults and adolescents over 16 years old, the administration instructions, and the precautions for individuals with reduced liver or kidney function. It also mentions that the medication should be taken with food and should not be taken on an empty stomach. The section advises to use the lowest effective dose and to discontinue the medication once the pain or fever symptoms have subsided.", "excerpt_keywords": "Acetilsalic\u00edlico, medicamento, prospecto, instrucciones, administraci\u00f3n, v\u00eda oral, comprimido, \u00e1cido acetilsalic\u00edlico, dosis, h\u00edgado, ri\u00f1\u00f3n, reducidas, agua, comidas, alimento, est\u00f3mago vac\u00edo, s\u00edntomas, dolorosos, febriles, suspender, medicaci\u00f3n, dolor, fiebre."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "0157b6a2-6481-4e44-9e0a-c7b6f7c8aee8", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "c98dcf55aac64e4a520c12db6feafd967395f14c05ce3030f9e3cb7682511ce6"}, "2": {"node_id": "2d17947a-41ce-48f6-a53f-baaa463dd60d", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "d0d495c1ad30bdc93c7b6ae15c936e64b1c170b95809e238fc7f2f5cfd772a87"}, "3": {"node_id": "1c15fa1a-24f2-4355-889d-5fbb1bbbc0fc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "198b9809293f83d7bca1f38d2dbdb7b65fbe3112ac05eb7f27e8468b7e76e5b7"}}, "hash": "f263a30bcc273d49b1eb022a4f49d1e01e6bc3fc5bdfa842ad0ed2c7d6248e0c", "text": "No se ha descrito ning\u00fan efecto sobre la capacidad para conducir o utilizar m\u00e1quinas. \n3. C\u00f3mo tomar Acetilsalic\u00edlico  \nSiga exactamente las instrucciones de administraci\u00f3n del medicamento contenidas en este \nprospecto o las  indicadas por su m\u00e9dico o farmac\u00e9utico. En caso de duda, pregunte a su \nm\u00e9dico o farmac\u00e9utico.  \nEste medicamento se admini stra por v\u00eda oral.  \nAdultos y adolescentes mayores de 16 a\u00f1os:  1 comprimido (500 mg de \u00e1cido acetilsalic\u00edlico) \ncada 4 \u00f3 6  horas, si fuera necesario. No se exceder\u00e1 de 8 comprimidos (4 g de \u00e1cido \nacetilsalic\u00edlico) en 24 horas.  \nPacientes con las funciones del h \u00edgado o ri\u00f1\u00f3n reducidas:  consultar al m\u00e9dico ya que debe \nreducir la dosis.  \nLos comprimidos deben tomarse con un vaso de agua, despu\u00e9s de las comidas o con alg\u00fan alimento. \nNo debe tomar este medicamento con el est\u00f3mago vac\u00edo.  \nUtilizar siempre la dosis menor que sea efectiva.  \nLa administraci\u00f3n de este preparado est\u00e1 supeditada a la aparici\u00f3n de los s\u00edntomas dolorosos o \nfebriles. A  medida que \u00e9stos desaparezcan debe suspenderse esta medicaci\u00f3n. \nSi el dolor se mantiene durante m\u00e1s de 5 d\u00edas, o la fiebre durante m\u00e1s de 3 d\u00edas, o bien los", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "1c15fa1a-24f2-4355-889d-5fbb1bbbc0fc": {"__data__": {"id_": "1c15fa1a-24f2-4355-889d-5fbb1bbbc0fc", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin)?\n2. How long should Acetilsalic\u00edlico be taken for pain relief or fever reduction?\n3. When should the treatment with Acetilsalic\u00edlico be discontinued and medical consultation sought?", "prev_section_summary": "The section provides information about the usage and precautions of Acetilsalic\u00edlico (Aspirin). It includes the recommended dosage for adults and adolescents over 16 years old, the administration instructions, and the precautions for individuals with reduced liver or kidney function. It also mentions that the medication should be taken with food and should not be taken on an empty stomach. The section advises to use the lowest effective dose and to discontinue the medication once the pain or fever symptoms have subsided.", "section_summary": "The section provides information about the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin). It states that the medication should be taken at the lowest effective dose and should be discontinued once the pain or fever symptoms disappear. If the pain persists for more than 5 days, fever for more than 3 days, or if new symptoms appear, medical consultation should be sought. The section also mentions the possibility of taking an overdose of Acetilsalic\u00edlico.", "excerpt_keywords": "dosis, efectiva, administraci\u00f3n, preparado, s\u00edntomas, dolorosos, febriles, suspenderse, medicaci\u00f3n, dolor, d\u00edas, fiebre, empeoran, aparecen, interrumpir, tratamiento, consultar, m\u00e9dico, tomar, acetilsalic\u00edlico"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "0157b6a2-6481-4e44-9e0a-c7b6f7c8aee8", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "c98dcf55aac64e4a520c12db6feafd967395f14c05ce3030f9e3cb7682511ce6"}, "2": {"node_id": "1253b748-c5c7-42b5-b518-184ac58e306b", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "f263a30bcc273d49b1eb022a4f49d1e01e6bc3fc5bdfa842ad0ed2c7d6248e0c"}}, "hash": "198b9809293f83d7bca1f38d2dbdb7b65fbe3112ac05eb7f27e8468b7e76e5b7", "text": "Utilizar siempre la dosis menor que sea efectiva.  \nLa administraci\u00f3n de este preparado est\u00e1 supeditada a la aparici\u00f3n de los s\u00edntomas dolorosos o \nfebriles. A  medida que \u00e9stos desaparezcan debe suspenderse esta medicaci\u00f3n. \nSi el dolor se mantiene durante m\u00e1s de 5 d\u00edas, o la fiebre durante m\u00e1s de 3 d\u00edas, o bien los \ns\u00edntomas  empeoran o aparecen otros distintos, debe interrumpir el tratamiento y consultar al \nm\u00e9dico.  \nSi toma m\u00e1s Acetilsalic\u00edlico de la que debe", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "a5d41920-3b65-4293-a13d-ded1c3fdd4b7": {"__data__": {"id_": "a5d41920-3b65-4293-a13d-ded1c3fdd4b7", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the common symptoms of an overdose of Acetilsalic\u00edlico (Aspirin) and what should be done in case of overdose?\n- The context provides information about the main symptoms of an overdose, such as headache, dizziness, blurred vision, and nausea. It also advises to consult a healthcare professional immediately or call the Poison Information Service in case of overdose or accidental ingestion.\n\n2. What are the potential adverse effects of Acetilsalic\u00edlico (Aspirin) and how frequently do they occur?\n- The context mentions that this medication can produce adverse effects, including gastrointestinal disorders such as stomach ulcers and bleeding, as well as respiratory disorders like difficulty breathing. It also states that these adverse effects can affect up to 1 in 10 people.\n\n3. What precautions and contraindications should be considered when using Acetilsalic\u00edlico (Aspirin)?\n- The context indicates that there are precautions and contraindications for the use of Acetilsalic\u00edlico, but it does not provide specific details. However, it suggests that the prospectus of the medication should be consulted and brought to a healthcare professional for more information.", "prev_section_summary": "The section provides information about the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin). It states that the medication should be taken at the lowest effective dose and should be discontinued once the pain or fever symptoms disappear. If the pain persists for more than 5 days, fever for more than 3 days, or if new symptoms appear, medical consultation should be sought. The section also mentions the possibility of taking an overdose of Acetilsalic\u00edlico.", "section_summary": "The key topics of this section are the symptoms of an overdose of Acetilsalic\u00edlico (Aspirin), potential adverse effects of the medication, precautions and contraindications for its use, and considerations for medication use in surgical procedures, pregnancy, and interactions with other medications. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), healthcare professionals, Poison Information Service, gastrointestinal disorders, respiratory disorders, and the prospectus of the medication.", "excerpt_keywords": "sobredosis, s\u00edntomas, dolor de cabeza, mareos, zumbido de o\u00eddos, visi\u00f3n borrosa, somnolencia, sudoraci\u00f3n, respiraci\u00f3n r\u00e1pida, confusi\u00f3n mental, n\u00e1useas, v\u00f3mitos, diarrea, envase, prospecto, profesional sanitario, m\u00e9dico, farmac\u00e9utico, centro m\u00e9dico, Servicio de Informaci\u00f3n Toxicol\u00f3gica, efectos adversos, trastornos gastrointestinales, \u00falcera de est\u00f3mago, \u00falcera de intestino, sangrado gastrointestinal, dolor del abdomen, digesti\u00f3n pesada, ardor, acidez, molestias g\u00e1stricas, trastornos respiratorios, dificultad para respirar, asma, espasmo bronquial, congesti\u00f3n nasal, rinitis"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "4a6bd37e-1900-483d-85be-27b8c62c19d3", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "f0509bde57b29e77278fc10404dce09675e3f45641d14f589cd12a4e34a56eae"}, "3": {"node_id": "a0749e3e-013d-4c4f-a750-7c8cc829e355", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "a1b2d48b82c2483a79d5b2c001ad6dc8f200f19b2d89d73e0ea3f67e69884d61"}}, "hash": "8c3ec2d3cf377f12d9a0b27a03c12f676e833e3d1424d5c4904c025f72cb522f", "text": "Los principales s\u00edntomas de la sobredosis son: dolor de cabeza, mareos, zumbido de o\u00eddos, \nvisi\u00f3n borrosa,  somnolencia, sudoraci\u00f3n, respiraci\u00f3n r\u00e1pida, confusi\u00f3n mental, n\u00e1useas, \nv\u00f3mitos y ocasionalmente diarrea.  \nSe recomendar\u00e1 llevar el envase y el prospecto del medicamento al profesional sanitario.  \nEn caso de sobredosis o ingesti\u00f3n acc idental, consulte inmediatamente a su m\u00e9dico o \nfarmac\u00e9utico o acuda  a un centro m\u00e9dico inmediatamente o llame al Servicio de Informaci\u00f3n \nToxicol\u00f3gica, indicando el medicamento y la cantidad ingerida.  \n4. Posibles efectos adversos  \nAl igual que todos los medi camentos, este medicamento puede producir efectos adversos, \naunque no todaslas personas los sufran.  \nEfectos adversos frecuentes (pueden afectar hasta 1 de cada 10 personas):  \n- Trastornos gastrointestinales, como \u00falcera de est\u00f3mago, \u00falcera de intestino, sangrado \ngastrointestinal,  dolor del abdomen, digesti\u00f3n pesada, ardor, acidez, molestias \ng\u00e1stricas, n\u00e1useas y v\u00f3mitos.  \n- Trastornos respiratorios, como dificultad para respirar (asma, espasmo bronquial), \ncongesti\u00f3n nasal yrinitis.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "a0749e3e-013d-4c4f-a750-7c8cc829e355": {"__data__": {"id_": "a0749e3e-013d-4c4f-a750-7c8cc829e355", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the potential gastrointestinal side effects of using Acetilsalic\u00edlico (Aspirin)?\n2. What are the less common adverse effects of prolonged use of Acetilsalic\u00edlico (Aspirin)?\n3. In what specific cases should Acetilsalic\u00edlico (Aspirin) be avoided or used with caution?", "prev_section_summary": "The key topics of this section are the symptoms of an overdose of Acetilsalic\u00edlico (Aspirin), potential adverse effects of the medication, precautions and contraindications for its use, and considerations for medication use in surgical procedures, pregnancy, and interactions with other medications. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), healthcare professionals, Poison Information Service, gastrointestinal disorders, respiratory disorders, and the prospectus of the medication.", "section_summary": "The section discusses the potential gastrointestinal side effects of using Acetilsalic\u00edlico (Aspirin), such as stomach ulcers, gastrointestinal bleeding, and abdominal pain. It also mentions respiratory disorders, skin reactions, and low blood clotting when administered in high doses. Less common adverse effects include Reye's syndrome in children, liver disorders, and anemia. Prolonged use of Acetilsalic\u00edlico may also lead to dizziness, tinnitus, sweating, headache, confusion, and hearing loss.", "excerpt_keywords": "trastornos gastrointestinales, \u00falcera de est\u00f3mago, \u00falcera de intestino, sangrado gastrointestinal, dolor del abdomen, digesti\u00f3n pesada, ardor, acidez, molestias g\u00e1stricas, n\u00e1useas, v\u00f3mitos, trastornos respiratorios, dificultad para respirar, asma, espasmo bronquial, congesti\u00f3n nasal, rinitis, urticaria, erupciones cut\u00e1neas, angioedema, picor, hipoprotrombinemia, s\u00edndrome de Reye, trastornos del h\u00edgado, anemia, mareos, ruidos en los o\u00eddos, sordera, sudoraci\u00f3n, dolor de cabeza, confusi\u00f3n, insuficiencia."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "4a6bd37e-1900-483d-85be-27b8c62c19d3", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "f0509bde57b29e77278fc10404dce09675e3f45641d14f589cd12a4e34a56eae"}, "2": {"node_id": "a5d41920-3b65-4293-a13d-ded1c3fdd4b7", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "8c3ec2d3cf377f12d9a0b27a03c12f676e833e3d1424d5c4904c025f72cb522f"}, "3": {"node_id": "5c698629-f998-49f7-a36c-e5947150c29a", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "b74fbcd0401299bc65bfde7a870b767ed87ed07acb23deb31acd886aedd45127"}}, "hash": "a1b2d48b82c2483a79d5b2c001ad6dc8f200f19b2d89d73e0ea3f67e69884d61", "text": "- Trastornos gastrointestinales, como \u00falcera de est\u00f3mago, \u00falcera de intestino, sangrado \ngastrointestinal,  dolor del abdomen, digesti\u00f3n pesada, ardor, acidez, molestias \ng\u00e1stricas, n\u00e1useas y v\u00f3mitos.  \n- Trastornos respiratorios, como dificultad para respirar (asma, espasmo bronquial), \ncongesti\u00f3n nasal yrinitis.  \n- Urticaria, erupciones cut\u00e1neas, angioedema (inflamaci\u00f3n e hinchaz\u00f3n que afecta a la cara, labios, boca,lengua o garganta, que puede causar dificultad al tragar o respirar) y \npicor.  \n- Hipoprotrombinemia (alteraci\u00f3n de la coagulaci\u00f3n) cuando se administra en dosis altas.  \nEfec tos adversos poco frecuentes (pueden afectar hasta 1 de cada 100 personas):  \n- S\u00edndrome de Reye en menores de 16 a\u00f1os con procesos febriles, gripe o varicela (ver apartado \u201cAntes de empezar a tomar Acetilsalic\u00edlico\u201d).  \n- Trastornos del h\u00edgado, especialmente en pacientes con artritis juvenil.  \n- Anemia.  \nCon dosis prolongadas de \u00e1cido acetilsalic\u00edlico, se han observado los siguientes efectos \nadversos cuya  frecuencia no se ha podido establecer con exactitud:   \nmareos, ruidos en los o\u00eddos, sordera, sudoraci\u00f3n, dolor  de cabeza, confusi\u00f3n, insuficiencia", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "5c698629-f998-49f7-a36c-e5947150c29a": {"__data__": {"id_": "5c698629-f998-49f7-a36c-e5947150c29a", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the potential adverse effects of prolonged use of Acetilsalic\u00edlico (Aspirin) and how often do they occur?\n- The context mentions that with prolonged use of Acetilsalic\u00edlico, adverse effects such as dizziness, ringing in the ears, sweating, headache, confusion, kidney failure, and acute interstitial nephritis (kidney inflammation) may occur. However, the frequency of these effects is not accurately established.\n\n2. What are the symptoms that may indicate the need to stop taking Acetilsalic\u00edlico and seek immediate medical attention?\n- The context states that if symptoms such as stomach discomfort or pain, gastrointestinal bleeding or black stools, skin disorders like rashes or redness, difficulty breathing, unexpected changes in urine quantity or appearance, facial, feet or leg swelling, hearing loss, ringing in the ears, or dizziness occur, the medication should be discontinued and immediate medical consultation is necessary.\n\n3. How should adverse effects of Acetilsalic\u00edlico be communicated?\n- The context mentions the importance of promptly informing a doctor if any adverse effects occur. It suggests that if symptoms indicating potential side effects requiring urgent medical attention appear, the medication should be stopped and the doctor should be consulted immediately.", "prev_section_summary": "The section discusses the potential gastrointestinal side effects of using Acetilsalic\u00edlico (Aspirin), such as stomach ulcers, gastrointestinal bleeding, and abdominal pain. It also mentions respiratory disorders, skin reactions, and low blood clotting when administered in high doses. Less common adverse effects include Reye's syndrome in children, liver disorders, and anemia. Prolonged use of Acetilsalic\u00edlico may also lead to dizziness, tinnitus, sweating, headache, confusion, and hearing loss.", "section_summary": "The section discusses the prospectus of Acetilsalic\u00edlico (Aspirin), including information for the user, its use as an anti-inflammatory and analgesic medication, precautions and contraindications, considerations for medication use during surgical procedures, pregnancy, and interactions with other medications. It also mentions potential adverse effects of prolonged use of Acetilsalic\u00edlico, such as dizziness, ringing in the ears, sweating, headache, confusion, kidney failure, and acute interstitial nephritis. The section highlights symptoms that may indicate the need to stop taking Acetilsalic\u00edlico and seek immediate medical attention, such as stomach discomfort or pain, gastrointestinal bleeding or black stools, skin disorders, difficulty breathing, changes in urine quantity or appearance, facial, feet or leg swelling, hearing loss, ringing in the ears, or dizziness. It emphasizes the importance of promptly informing a doctor if any adverse effects occur and suggests discontinuing the medication and consulting a doctor immediately if symptoms indicating potential side effects requiring urgent medical attention appear.", "excerpt_keywords": "Anemia, \u00e1cido acetilsalic\u00edlico, dosis prolongadas, efectos adversos, mareos, ruidos en los o\u00eddos, sordera, sudoraci\u00f3n, dolor de cabeza, confusi\u00f3n, insuficiencia renal, nefritis intersticial aguda, inflamaci\u00f3n renal, malestar estomacal, hemorragia g\u00e1strica, deposiciones negras, trastornos de la piel, dificultad para respirar, cambio en la orina, hinchaz\u00f3n, sordera, zumbidos de o\u00eddos, consulta m\u00e9dica, atenci\u00f3n m\u00e9dica urgente."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "4a6bd37e-1900-483d-85be-27b8c62c19d3", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "f0509bde57b29e77278fc10404dce09675e3f45641d14f589cd12a4e34a56eae"}, "2": {"node_id": "a0749e3e-013d-4c4f-a750-7c8cc829e355", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "a1b2d48b82c2483a79d5b2c001ad6dc8f200f19b2d89d73e0ea3f67e69884d61"}}, "hash": "b74fbcd0401299bc65bfde7a870b767ed87ed07acb23deb31acd886aedd45127", "text": "- Anemia.  \nCon dosis prolongadas de \u00e1cido acetilsalic\u00edlico, se han observado los siguientes efectos \nadversos cuya  frecuencia no se ha podido establecer con exactitud:   \nmareos, ruidos en los o\u00eddos, sordera, sudoraci\u00f3n, dolor  de cabeza, confusi\u00f3n, insuficiencia \nrenal y nefritis intersticial aguda (inflamaci\u00f3n a nivel del ri\u00f1\u00f3n).  \nSi observa la aparici\u00f3n de:  \n\u2022 malestar o dolor de est\u00f3mago, hemorragia g\u00e1strica o intestinal o deposiciones negras,  \n\u2022 trastornos de la piel, tales como erupcio nes o enrojecimiento,  \n\u2022 dificultad para respirar,  \n\u2022 cambio imprevisto de la cantidad o el aspecto de la orina,  \n\u2022 hinchaz\u00f3n de la cara, de los pies o de las piernas,  \n\u2022 sordera, zumbidos de o\u00eddos o mareos,  \ndeje de tomar el medicamento y consulte a su m\u00e9dico inmediat amente, ya que pueden indicar \nla aparici\u00f3n de efectos secundarios que necesitan atenci\u00f3n m\u00e9dica urgente.  \nComunicaci\u00f3n de efectos adversos", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "65f11215-5f65-4ac3-a10d-89d3781dd5a2": {"__data__": {"id_": "65f11215-5f65-4ac3-a10d-89d3781dd5a2", "embedding": null, "metadata": {"page_label": "6", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for the use of Acetilsalic\u00edlico (Aspirin)?\n2. How should Acetilsalic\u00edlico be stored and disposed of properly?\n3. What is the composition of Acetilsalic\u00edlico and what are its active ingredients?", "prev_section_summary": "The section discusses the prospectus of Acetilsalic\u00edlico (Aspirin), including information for the user, its use as an anti-inflammatory and analgesic medication, precautions and contraindications, considerations for medication use during surgical procedures, pregnancy, and interactions with other medications. It also mentions potential adverse effects of prolonged use of Acetilsalic\u00edlico, such as dizziness, ringing in the ears, sweating, headache, confusion, kidney failure, and acute interstitial nephritis. The section highlights symptoms that may indicate the need to stop taking Acetilsalic\u00edlico and seek immediate medical attention, such as stomach discomfort or pain, gastrointestinal bleeding or black stools, skin disorders, difficulty breathing, changes in urine quantity or appearance, facial, feet or leg swelling, hearing loss, ringing in the ears, or dizziness. It emphasizes the importance of promptly informing a doctor if any adverse effects occur and suggests discontinuing the medication and consulting a doctor immediately if symptoms indicating potential side effects requiring urgent medical attention appear.", "section_summary": "The key topics of this section are the precautions and contraindications for the use of Acetilsalic\u00edlico (Aspirin), the proper storage and disposal of Acetilsalic\u00edlico, and the composition of Acetilsalic\u00edlico and its active ingredients. The section also mentions the communication of adverse effects and the conservation of Acetilsalic\u00edlico. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), m\u00e9dico (doctor), farmac\u00e9utico (pharmacist), Sistema de Farmacovigilancia de medicamentos de Uso Humano (Pharmacovigilance System for Human Medicines), ni\u00f1os (children), fecha de caducidad (expiration date), envases (packaging), Punto descarte de la farmacia (pharmacy disposal point), and medio ambiente (environment).", "excerpt_keywords": "efectos adversos, m\u00e9dico, farmac\u00e9utico, prospecto, comunicaci\u00f3n, seguridad, conservaci\u00f3n, temperatura, ni\u00f1os, fecha de caducidad, desecho, medio ambiente, comprimido, \u00e1cido acetilsalic\u00edlico, componentes."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "1d8ce9aa-a4b3-4e4d-b27c-d45113e1d583", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "34be41a934880950eca0302bfe0d503b2cb05631f9f41f25d79f6a5192da4293"}, "3": {"node_id": "ee8d9acb-1ef8-4bfe-bf5a-58c63321b0ab", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "f2871b857db17ed8f2c997a6c4e2d6aefc9afe3aaa921132aee7f22ad5ea1547"}}, "hash": "514ab73e38dd02221875ab1a972d4b8733b869e4d47ac123ff12ebc6b39aef1c", "text": "Si experimenta cualquier tipo de efecto adverso, consulte a su m\u00e9dico o farmac\u00e9utico, incluso \nsi se trata de  posibles efectos adversos que no aparecen en este prospecto. Tambi\u00e9n puede \ncomunicarlos directamente a  trav\u00e9s del Sistema de Farmacovigilancia de medicamentos de \nUso Humano . \nMediante la comunicaci\u00f3n de efectos adversos usted puede contribuir a proporcionar m\u00e1s \ninformaci\u00f3n  sobre la seguridad de este medicamento. \n5. Conservaci\u00f3n de Acetilsalic\u00edlico  \nNo conservar a temperatura superior a 30\u00baC.  \nMantener este medicamento fuera de la vista y del alcance de los ni\u00f1os.  \nNo utilice este medicamento despu\u00e9s de la fecha de caducidad que aparece en el envase, tras \nla abreviatura \nCAD. La fecha de caducidad es el \u00faltimo d\u00eda del mes que se indica.  \nLos medicamentos no se deben tirar por los desag\u00fces ni a la basura. Deposite los envases y los \nmedicamentos que no necesita en el Punto descarte de la farmacia. En caso de duda pregunte \na su farmac\u00e9utico c\u00f3mo deshacerse de los envases y de los medicamentos que ya no necesita. \nDe esta forma,  ayudar\u00e1 a proteger el medio ambiente. \n6. Contenido del enva se e informaci\u00f3n adicional  \nComposici\u00f3n de Acetilsalic\u00edlico  \nCada comprimido contiene como principio activo: \u00e1cido acetilsalic\u00edlico, 500 mg. Los dem\u00e1s \ncomponentes", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "ee8d9acb-1ef8-4bfe-bf5a-58c63321b0ab": {"__data__": {"id_": "ee8d9acb-1ef8-4bfe-bf5a-58c63321b0ab", "embedding": null, "metadata": {"page_label": "6", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for the use of Acetilsalic\u00edlico (Aspirin)?\n2. What are the considerations for medication use of Acetilsalic\u00edlico in surgical procedures, pregnancy, and interactions with other medications?\n3. What is the composition of Acetilsalic\u00edlico and what are its excipients?", "prev_section_summary": "The key topics of this section are the precautions and contraindications for the use of Acetilsalic\u00edlico (Aspirin), the proper storage and disposal of Acetilsalic\u00edlico, and the composition of Acetilsalic\u00edlico and its active ingredients. The section also mentions the communication of adverse effects and the conservation of Acetilsalic\u00edlico. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), m\u00e9dico (doctor), farmac\u00e9utico (pharmacist), Sistema de Farmacovigilancia de medicamentos de Uso Humano (Pharmacovigilance System for Human Medicines), ni\u00f1os (children), fecha de caducidad (expiration date), envases (packaging), Punto descarte de la farmacia (pharmacy disposal point), and medio ambiente (environment).", "section_summary": "The key topics of this section are the precautions and contraindications for the use of Acetilsalic\u00edlico (Aspirin), the considerations for medication use in surgical procedures, pregnancy, and interactions with other medications, and the composition of Acetilsalic\u00edlico and its excipients. The section also mentions the packaging and appearance of Acetilsalic\u00edlico, as well as the pharmaceutical company responsible for its manufacturing and distribution.", "excerpt_keywords": "proteger, medio ambiente, contenido, envase, informaci\u00f3n adicional, composici\u00f3n, acetilsalic\u00edlico, comprimido, principio activo, \u00e1cido acetilsalic\u00edlico, componentes, excipientes, celulosa en polvo, almid\u00f3n de ma\u00edz, aspecto, color blanco, anagrama de cruz, blisters, propileno, aluminio, titular, autorizaci\u00f3n de comercializaci\u00f3n, laboratorio, fabricaci\u00f3n, revisi\u00f3n, prospecto, septiembre 2023."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "1d8ce9aa-a4b3-4e4d-b27c-d45113e1d583", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "34be41a934880950eca0302bfe0d503b2cb05631f9f41f25d79f6a5192da4293"}, "2": {"node_id": "65f11215-5f65-4ac3-a10d-89d3781dd5a2", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf"}, "hash": "514ab73e38dd02221875ab1a972d4b8733b869e4d47ac123ff12ebc6b39aef1c"}}, "hash": "f2871b857db17ed8f2c997a6c4e2d6aefc9afe3aaa921132aee7f22ad5ea1547", "text": "De esta forma,  ayudar\u00e1 a proteger el medio ambiente. \n6. Contenido del enva se e informaci\u00f3n adicional  \nComposici\u00f3n de Acetilsalic\u00edlico  \nCada comprimido contiene como principio activo: \u00e1cido acetilsalic\u00edlico, 500 mg. Los dem\u00e1s \ncomponentes  \n(excipientes) son: celulosa en polvo y almid\u00f3n de ma\u00edz.  \nAspecto de Acetilsalic\u00edlico y contenido  del envase  \nComprimidos redondos y de color blanco con el anagrama de cruz en una cara . \nSe presenta en blisters de propileno y aluminio con 10 comprimidos. \nEnvases con 10 o 20 comprimidos.  \nPuede que solamente est\u00e9n comercializados algunos tama\u00f1os de envases.  \nTitular de la autorizaci\u00f3n de comercializaci\u00f3n  \nLaboratorio  Pharma.IA , \nResponsable de la fabricaci\u00f3n  \nLaboratorio  Pharma.IA , \nFecha de la \u00faltima revisi\u00f3n de este prospecto: septiembre 2023", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}}, "docstore/ref_doc_info": {"80135828-8074-43e0-a063-d6b0926b7179": {"node_ids": ["c63cf7de-365f-45f9-8a21-51bb0f94cda1", "668cd82f-7472-4059-b196-9e4d723b3996"], "metadata": {"page_label": "1", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin)?\n2. What are the considerations for using Acetilsalic\u00edlico (Aspirin) during surgical procedures, pregnancy, and interactions with other medications?\n3. What is the recommended dosage and administration instructions for Acetilsalic\u00edlico (Aspirin) in oral tablets?", "section_summary": "The section provides information about the prospectus of Acetilsalic\u00edlico (Aspirin), including its precautions and contraindications, considerations for use during surgical procedures, pregnancy, and interactions with other medications. It also mentions the recommended dosage and administration instructions for Acetilsalic\u00edlico in oral tablets. The section emphasizes the importance of reading the prospectus carefully and consulting a healthcare professional for advice or more information. The key topics covered include the use and benefits of Acetilsalic\u00edlico, its classification as a non-steroidal anti-inflammatory drug (NSAID), and its ability to relieve pain and reduce fever. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), the active ingredient, and the potential users of the medication.", "excerpt_keywords": "acetilsalic\u00edlico, 500 mg, v\u00eda oral, comprimidos recubiertos, prospecto, informaci\u00f3n, usuario, medicamento, instrucciones, administraci\u00f3n, m\u00e9dico, farmac\u00e9utico, consejo, efectos adversos, dolor, fiebre, \u00e1cido acetilsalic\u00edlico, antiinflamatorios no esteroideos, alivio sintom\u00e1tico, dolores ocasionales, leves, moderados."}}, "9698a130-2127-47db-893f-7992771f3c74": {"node_ids": ["c0e01ead-0ea5-4dcc-929e-7a0fcdf817a2", "ad451347-fd33-45d6-a4f6-42616bf1636a", "12f9f651-f553-4b67-8ac7-3788383d27b7"], "metadata": {"page_label": "2", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) in patients with asthma or allergic reactions to anti-inflammatory drugs?\n2. Can Acetilsalic\u00edlico be used in patients with kidney or liver diseases, hypertension, or blood clotting disorders?\n3. Is it safe to use Acetilsalic\u00edlico during pregnancy, particularly in the third trimester?", "prev_section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin), considerations for using Acetilsalic\u00edlico during surgical procedures, pregnancy, and interactions with other medications, and the symptoms and conditions that Acetilsalic\u00edlico can be used to treat. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), surgical procedures, pregnancy, and other medications.", "section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin). It mentions that patients with asthma or allergic reactions to anti-inflammatory drugs should not take Acetilsalic\u00edlico. It also states that patients with kidney or liver diseases, hypertension, blood clotting disorders, or in their third trimester of pregnancy should use Acetilsalic\u00edlico with caution and consult their doctor. The section also mentions the potential risks of using Acetilsalic\u00edlico in patients under 16 years old, as it has been associated with a rare but serious condition called Reye's syndrome.", "excerpt_keywords": "reacciones al\u00e9rgicas, asm\u00e1tico, dificultad para respirar, ahogo, broncoespasmos, tos, pitidos al respirar, antiinflamatorios, \u00e1cido acetilsalic\u00edlico, analg\u00e9sicos, colorante tartrazina, asma, p\u00f3lipos nasal, hemofilia, coagulaci\u00f3n sangu\u00ednea, medicamentos anticoagulantes orales, enfermedades del ri\u00f1\u00f3n, insuficiencia renal, enfermedades del h\u00edgado, insuficiencia hep\u00e1tica, S\u00edndrome de Reye, tercer trimestre del embarazo, hipertensi\u00f3n arterial, funciones del ri\u00f1\u00f3n, funciones del coraz\u00f3n, funciones del h\u00edgado, alteraciones en la coagulaci\u00f3n sangu\u00ednea."}}, "584f8311-4757-4ffb-9338-094200dd2e7e": {"node_ids": ["ed8eb388-de37-4edb-aa86-3588e5536406", "0a33b138-c6b5-4c8d-8f40-c5808ed86b4a"], "metadata": {"page_label": "3", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the potential drug interactions and contraindications for Acetilsalic\u00edlico (Aspirin) use?\n- The context provides a list of medications that may interact with Acetilsalic\u00edlico, such as anticoagulants, antidiabetic drugs, barbiturates, betablockers, and more.\n\n2. What are the precautions and considerations for using Acetilsalic\u00edlico (Aspirin) during surgical procedures and pregnancy?\n- The context mentions considerations for medication use during surgical procedures and pregnancy, indicating that there may be specific precautions or risks associated with using Acetilsalic\u00edlico in these situations.\n\n3. What are the potential risks and contraindications of using Acetilsalic\u00edlico (Aspirin) for individuals with certain medical conditions?\n- The context mentions specific medical conditions, such as high blood pressure, epilepsy, cancer, and arthritis, and suggests that Acetilsalic\u00edlico may have contraindications or risks for individuals with these conditions.", "prev_section_summary": "The section provides information about the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) before undergoing surgical procedures, its safety during the first and second trimester of pregnancy, and potential interactions with other medications. It advises against using Acetilsalic\u00edlico before surgery, during early pregnancy, and for preventing discomfort from vaccinations. It also mentions the importance of informing healthcare professionals about other medications, including over-the-counter drugs, homeopathic remedies, and herbal supplements, as they may require adjustments or discontinuation of treatment. Additionally, it highlights the potential interactions with other analgesics or non-steroidal anti-inflammatory drugs.", "section_summary": "The key topics of this section are the potential drug interactions and contraindications for Acetilsalic\u00edlico (Aspirin) use, the precautions and considerations for using Acetilsalic\u00edlico during surgical procedures and pregnancy, and the potential risks and contraindications of using Acetilsalic\u00edlico for individuals with certain medical conditions. The entities mentioned include specific medications that may interact with Acetilsalic\u00edlico, such as anticoagulants, antidiabetic drugs, barbiturates, betablockers, and more. Medical conditions such as high blood pressure, epilepsy, cancer, and arthritis are also mentioned.", "excerpt_keywords": "antidepresivos, inhibidores selectivos de la recaptaci\u00f3n de serotonina, hemorragia, anticoagulantes, warfarina, antidiab\u00e9ticos orales, barbit\u00faricos, convulsiones, betabloqueantes, cimetidina, ranitidina, ciclosporina, tacrolimus, corticoides, hemorragia digestiva, digoxina, presi\u00f3n arterial alta, diur\u00e9ticos, inhibidores de ECA, fenito\u00edna, \u00e1cido valproico, antiepil\u00e9pticos, interfer\u00f3n alfa, infecciones v\u00edricas, tumorales, litio, enfermedad psiqui\u00e1trica, c\u00e1ncer, artritis reumatoide, metotrexato, gota, probenecid."}}, "0157b6a2-6481-4e44-9e0a-c7b6f7c8aee8": {"node_ids": ["2d17947a-41ce-48f6-a53f-baaa463dd60d", "1253b748-c5c7-42b5-b518-184ac58e306b", "1c15fa1a-24f2-4355-889d-5fbb1bbbc0fc"], "metadata": {"page_label": "4", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) during pregnancy?\n- This context specifically mentions that the consumption of Acetilsalic\u00edlico during the first and second trimester of pregnancy can be dangerous for the embryo or fetus and should be monitored by a doctor. It also advises against taking the medication during the third trimester as it may prolong labor and contribute to bleeding for both the mother and baby.\n\n2. Should women who are breastfeeding consult a doctor before using Acetilsalic\u00edlico?\n- Yes, according to the context, women who are breastfeeding should consult a doctor or pharmacist before using this medication as Acetilsalic\u00edlico can pass into breast milk.\n\n3. Is there an age restriction for the use of Acetilsalic\u00edlico?\n- Yes, the context states that Acetilsalic\u00edlico should not be administered to children under the age of 16.", "prev_section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin), the medications that can interact with Acetilsalic\u00edlico, and the interaction between Acetilsalic\u00edlico and alcohol. The entities mentioned include interfer\u00f3n alfa, litio, metotrexato, probenecid, vancomicina, zidovudina, and alcohol.", "section_summary": "The key topics of this section are the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin) during pregnancy, the need for consultation with a doctor before using Acetilsalic\u00edlico while breastfeeding, the age restriction for the use of Acetilsalic\u00edlico in children under 16, and the consideration for older adults to consult a doctor before taking the medication. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), pregnancy, breastfeeding, children, and older adults.", "excerpt_keywords": "embarazo, medicamento, peligroso, embri\u00f3n, feto, vigilado, tercer trimestre, prolongar, parto, sangrado, lactancia, \u00e1cido acetilsalic\u00edlico, leche materna, ni\u00f1os, menores de 16 a\u00f1os, mayores de 65 a\u00f1os, efectos adversos, conducci\u00f3n, m\u00e1quinas, instrucciones, prospecto, duda, m\u00e9dico, farmac\u00e9utico."}}, "4a6bd37e-1900-483d-85be-27b8c62c19d3": {"node_ids": ["a5d41920-3b65-4293-a13d-ded1c3fdd4b7", "a0749e3e-013d-4c4f-a750-7c8cc829e355", "5c698629-f998-49f7-a36c-e5947150c29a"], "metadata": {"page_label": "5", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the common symptoms of an overdose of Acetilsalic\u00edlico (Aspirin) and what should be done in case of overdose?\n- The context provides information about the main symptoms of an overdose, such as headache, dizziness, blurred vision, and nausea. It also advises to consult a healthcare professional immediately or call the Poison Information Service in case of overdose or accidental ingestion.\n\n2. What are the potential adverse effects of Acetilsalic\u00edlico (Aspirin) and how frequently do they occur?\n- The context mentions that this medication can produce adverse effects, including gastrointestinal disorders such as stomach ulcers and bleeding, as well as respiratory disorders like difficulty breathing. It also states that these adverse effects can affect up to 1 in 10 people.\n\n3. What precautions and contraindications should be considered when using Acetilsalic\u00edlico (Aspirin)?\n- The context indicates that there are precautions and contraindications for the use of Acetilsalic\u00edlico, but it does not provide specific details. However, it suggests that the prospectus of the medication should be consulted and brought to a healthcare professional for more information.", "prev_section_summary": "The section provides information about the precautions and contraindications for using Acetilsalic\u00edlico (Aspirin). It states that the medication should be taken at the lowest effective dose and should be discontinued once the pain or fever symptoms disappear. If the pain persists for more than 5 days, fever for more than 3 days, or if new symptoms appear, medical consultation should be sought. The section also mentions the possibility of taking an overdose of Acetilsalic\u00edlico.", "section_summary": "The key topics of this section are the symptoms of an overdose of Acetilsalic\u00edlico (Aspirin), potential adverse effects of the medication, precautions and contraindications for its use, and considerations for medication use in surgical procedures, pregnancy, and interactions with other medications. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), healthcare professionals, Poison Information Service, gastrointestinal disorders, respiratory disorders, and the prospectus of the medication.", "excerpt_keywords": "sobredosis, s\u00edntomas, dolor de cabeza, mareos, zumbido de o\u00eddos, visi\u00f3n borrosa, somnolencia, sudoraci\u00f3n, respiraci\u00f3n r\u00e1pida, confusi\u00f3n mental, n\u00e1useas, v\u00f3mitos, diarrea, envase, prospecto, profesional sanitario, m\u00e9dico, farmac\u00e9utico, centro m\u00e9dico, Servicio de Informaci\u00f3n Toxicol\u00f3gica, efectos adversos, trastornos gastrointestinales, \u00falcera de est\u00f3mago, \u00falcera de intestino, sangrado gastrointestinal, dolor del abdomen, digesti\u00f3n pesada, ardor, acidez, molestias g\u00e1stricas, trastornos respiratorios, dificultad para respirar, asma, espasmo bronquial, congesti\u00f3n nasal, rinitis"}}, "1d8ce9aa-a4b3-4e4d-b27c-d45113e1d583": {"node_ids": ["65f11215-5f65-4ac3-a10d-89d3781dd5a2", "ee8d9acb-1ef8-4bfe-bf5a-58c63321b0ab"], "metadata": {"page_label": "6", "file_name": "Prospecto Acetilsalic\u00edlico Generico.pdf", "document_title": "Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precautions and Contraindications for Acetilsalic\u00edlico (Aspirin) Use, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Considerations for Medication Use: Surgical Procedures, Pregnancy, and Interactions with Other Medications.\n\nComprehensive Title: Prospecto de Acetilsalic\u00edlico: Informaci\u00f3n para el usuario, Medicamento antiinflamatorio y analg\u00e9sico: \u00c1cido acetilsalic\u00edlico, Precauciones y contraindicaciones del uso de Acetilsalic\u00edlico, Consideraciones para el uso de medicamentos: Procedimientos quir\u00fargicos, embarazo e interacciones con otros medicamentos.", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for the use of Acetilsalic\u00edlico (Aspirin)?\n2. How should Acetilsalic\u00edlico be stored and disposed of properly?\n3. What is the composition of Acetilsalic\u00edlico and what are its active ingredients?", "prev_section_summary": "The section discusses the prospectus of Acetilsalic\u00edlico (Aspirin), including information for the user, its use as an anti-inflammatory and analgesic medication, precautions and contraindications, considerations for medication use during surgical procedures, pregnancy, and interactions with other medications. It also mentions potential adverse effects of prolonged use of Acetilsalic\u00edlico, such as dizziness, ringing in the ears, sweating, headache, confusion, kidney failure, and acute interstitial nephritis. The section highlights symptoms that may indicate the need to stop taking Acetilsalic\u00edlico and seek immediate medical attention, such as stomach discomfort or pain, gastrointestinal bleeding or black stools, skin disorders, difficulty breathing, changes in urine quantity or appearance, facial, feet or leg swelling, hearing loss, ringing in the ears, or dizziness. It emphasizes the importance of promptly informing a doctor if any adverse effects occur and suggests discontinuing the medication and consulting a doctor immediately if symptoms indicating potential side effects requiring urgent medical attention appear.", "section_summary": "The key topics of this section are the precautions and contraindications for the use of Acetilsalic\u00edlico (Aspirin), the proper storage and disposal of Acetilsalic\u00edlico, and the composition of Acetilsalic\u00edlico and its active ingredients. The section also mentions the communication of adverse effects and the conservation of Acetilsalic\u00edlico. The key entities mentioned are Acetilsalic\u00edlico (Aspirin), m\u00e9dico (doctor), farmac\u00e9utico (pharmacist), Sistema de Farmacovigilancia de medicamentos de Uso Humano (Pharmacovigilance System for Human Medicines), ni\u00f1os (children), fecha de caducidad (expiration date), envases (packaging), Punto descarte de la farmacia (pharmacy disposal point), and medio ambiente (environment).", "excerpt_keywords": "efectos adversos, m\u00e9dico, farmac\u00e9utico, prospecto, comunicaci\u00f3n, seguridad, conservaci\u00f3n, temperatura, ni\u00f1os, fecha de caducidad, desecho, medio ambiente, comprimido, \u00e1cido acetilsalic\u00edlico, componentes."}}}, "docstore/metadata": {"c63cf7de-365f-45f9-8a21-51bb0f94cda1": {"doc_hash": "8881d98051aecdb68d661372fb333a7bdfe15a22f887f3de7c7c854e53c999a8", "ref_doc_id": "80135828-8074-43e0-a063-d6b0926b7179"}, "668cd82f-7472-4059-b196-9e4d723b3996": {"doc_hash": "05551e077471d767bc1ca6e2de6e7acca6dea7a289bd79aebac3dc463bfeab10", "ref_doc_id": "80135828-8074-43e0-a063-d6b0926b7179"}, "c0e01ead-0ea5-4dcc-929e-7a0fcdf817a2": {"doc_hash": "82cde4e6cf847bd126352b0b6541d3c933fcae82aecd716e25661178a7cce04f", "ref_doc_id": "9698a130-2127-47db-893f-7992771f3c74"}, "ad451347-fd33-45d6-a4f6-42616bf1636a": {"doc_hash": "451382477c336cf8966fdfd4292323b226cd2b4cbbfd4d34e184ffe3921199f5", "ref_doc_id": "9698a130-2127-47db-893f-7992771f3c74"}, "12f9f651-f553-4b67-8ac7-3788383d27b7": {"doc_hash": "a8ebfa20e2570f063fd546db9d3a58fcd6d54dbee88909361ca7c2bb4963f883", "ref_doc_id": "9698a130-2127-47db-893f-7992771f3c74"}, "ed8eb388-de37-4edb-aa86-3588e5536406": {"doc_hash": "2887cc0d332a4b29dadc6055bdf801a5bdcb63bc28c9487e34f8f2f5cade43d1", "ref_doc_id": "584f8311-4757-4ffb-9338-094200dd2e7e"}, "0a33b138-c6b5-4c8d-8f40-c5808ed86b4a": {"doc_hash": "69fb74d9a060108038571d36e42294c5aa0c8027dba165f9660c18ec2ae89ec4", "ref_doc_id": "584f8311-4757-4ffb-9338-094200dd2e7e"}, "2d17947a-41ce-48f6-a53f-baaa463dd60d": {"doc_hash": "d0d495c1ad30bdc93c7b6ae15c936e64b1c170b95809e238fc7f2f5cfd772a87", "ref_doc_id": "0157b6a2-6481-4e44-9e0a-c7b6f7c8aee8"}, "1253b748-c5c7-42b5-b518-184ac58e306b": {"doc_hash": "f263a30bcc273d49b1eb022a4f49d1e01e6bc3fc5bdfa842ad0ed2c7d6248e0c", "ref_doc_id": "0157b6a2-6481-4e44-9e0a-c7b6f7c8aee8"}, "1c15fa1a-24f2-4355-889d-5fbb1bbbc0fc": {"doc_hash": "198b9809293f83d7bca1f38d2dbdb7b65fbe3112ac05eb7f27e8468b7e76e5b7", "ref_doc_id": "0157b6a2-6481-4e44-9e0a-c7b6f7c8aee8"}, "a5d41920-3b65-4293-a13d-ded1c3fdd4b7": {"doc_hash": "8c3ec2d3cf377f12d9a0b27a03c12f676e833e3d1424d5c4904c025f72cb522f", "ref_doc_id": "4a6bd37e-1900-483d-85be-27b8c62c19d3"}, "a0749e3e-013d-4c4f-a750-7c8cc829e355": {"doc_hash": "a1b2d48b82c2483a79d5b2c001ad6dc8f200f19b2d89d73e0ea3f67e69884d61", "ref_doc_id": "4a6bd37e-1900-483d-85be-27b8c62c19d3"}, "5c698629-f998-49f7-a36c-e5947150c29a": {"doc_hash": "b74fbcd0401299bc65bfde7a870b767ed87ed07acb23deb31acd886aedd45127", "ref_doc_id": "4a6bd37e-1900-483d-85be-27b8c62c19d3"}, "65f11215-5f65-4ac3-a10d-89d3781dd5a2": {"doc_hash": "514ab73e38dd02221875ab1a972d4b8733b869e4d47ac123ff12ebc6b39aef1c", "ref_doc_id": "1d8ce9aa-a4b3-4e4d-b27c-d45113e1d583"}, "ee8d9acb-1ef8-4bfe-bf5a-58c63321b0ab": {"doc_hash": "f2871b857db17ed8f2c997a6c4e2d6aefc9afe3aaa921132aee7f22ad5ea1547", "ref_doc_id": "1d8ce9aa-a4b3-4e4d-b27c-d45113e1d583"}}}
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+{"docstore/data": {"38581f5e-de4f-43d9-9051-bec1e0402c29": {"__data__": {"id_": "38581f5e-de4f-43d9-9051-bec1e0402c29", "embedding": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the different dosages available for Vortioxetine and what is the active ingredient in each dosage?\n2. What is the purpose of Vortioxetine and what condition does it treat in adults?\n3. What precautions should be taken before starting to take Vortioxetine and when should this medication not be taken?", "section_summary": "This section provides information about the medication Vortioxetine, including its dosages, active ingredient, purpose, and precautions. The dosages available for Vortioxetine are 5mg, 10mg, and 20mg, with the active ingredient being Vortioxetine bromhydrate. Vortioxetine is used to treat major depression in adults. Before starting to take Vortioxetine, it is important to consider certain precautions and avoid taking the medication under certain circumstances.", "excerpt_keywords": "Vortioxetina, medicamento, prospecto, informaci\u00f3n, usuario, v\u00eda oral, comprimidos recubiertos, vigilancia adicional, tratamiento, recetado, personas, s\u00edntomas, duda, efecto adverso, m\u00e9dico, f\u00f3rmulas, bromhidrato, principio activo, antidepresivos, episodios, depresi\u00f3n mayor, adultos, tomar."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "522ac278-4954-44be-bf8c-ffca1be2f1bc", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "a3cf722ec73bc3363a8ebb48fa6ed82fc4c945311da028e424989d1b5f5b89bf"}, "3": {"node_id": "89cfbb89-9985-4563-8e0a-c30b7816aa39", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "eadf913a5dd2a8113d26a409e651e8c7cebe9cf242488f3e87399389dcd5aa5d"}}, "hash": "c496fade0ab667bf370e31b8ad9afa38de9a0950936e88bc42b15a8a6ff76a5d", "text": "Prospecto: informaci\u00f3n para el usuario \nVortioxetina \n \nV\u00eda oral  - Comprimidos recubiertos \nMedicamento con vigilancia adicional  \nLEA TODO EL PROSPECTO DETENIDAMENTE ANTES DE COMENZAR EL TRATAMIENTO  \nConserve este prospecto, ya que puede tener que volver a leerlo. Este medicamento se le ha \nrecetado a usted y no debe d\u00e1rselo a otras personas, aunque tengan los mismos s\u00edntomas. Si \ntiene alguna duda o si considera que presenta alg\u00fan efecto adverso, consulte a su m\u00e9dico.  \nF\u00d3RMULAS  \nVortioxetina 5: Cada comprimido recubierto contiene:  \nVortioxetina (como bromhidrato)  5,0 mg  \nVortioxetina 10: Cada comprimido recubierto contiene:  \nVortioxetina (como bromhidrato)  10,0 mg  \nVortioxetina 20: Cada comprimido recubierto contiene:  \nVortioxetina (como bromhidrato ) 20,0 mg  \nQU\u00c9 ES VORTIOXETINA Y PARA QU\u00c9 SE UTILIZA  \nVortioxetina contiene como principio activo a la Vortioxetina. \u00c9ste pertenece a un grupo de medicamentos llamados antidepresivos. Vortioxetina se utiliza para tratar episodios de \ndepresi\u00f3n mayor en adultos. \nQU\u00c9 NECESITA SABER ANTES DE EMPEZAR A TOMAR VORTIOXETINA  \nNo tome este medicamento si:", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "89cfbb89-9985-4563-8e0a-c30b7816aa39": {"__data__": {"id_": "89cfbb89-9985-4563-8e0a-c30b7816aa39", "embedding": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for taking Vortioxetine?\n2. What are the potential risks and side effects of taking Vortioxetine for treating major depression in adults?\n3. What are the symptoms of Serotonin Syndrome (SS) and Neuroleptic Malignant Syndrome (SNM) that may occur when taking Vortioxetine in combination with other medications?", "prev_section_summary": "This section provides information about the medication Vortioxetine, including its dosages, active ingredient, purpose, and precautions. The dosages available for Vortioxetine are 5mg, 10mg, and 20mg, with the active ingredient being Vortioxetine bromhydrate. Vortioxetine is used to treat major depression in adults. Before starting to take Vortioxetine, it is important to consider certain precautions and avoid taking the medication under certain circumstances.", "section_summary": "This section provides important information about Vortioxetine, including precautions, contraindications, and risks associated with its use for treating major depression in adults. The section mentions that Vortioxetine is an antidepressant medication and should not be taken by individuals who are allergic to Vortioxetine or any of its components, or who are taking certain other medications such as non-selective monoamine oxidase inhibitors (MAOIs) or selective MAO-A inhibitors. It also advises caution when taking Vortioxetine in combination with medications that affect serotonin metabolism, serotoninergic active substances, antipsychotics, and other dopaminergic antagonists, as this may increase the risk of serotonin syndrome (SS) or neuroleptic malignant syndrome (SNM). The symptoms of SS are not mentioned in the provided excerpt.", "excerpt_keywords": "Vortioxetina, principio activo, antidepresivos, depresi\u00f3n mayor, al\u00e9rgico, inhibidores no selectivos de la monoaminooxidasa, inhibidores selectivos de la MAO-A, precauci\u00f3n, medicamentos serotonin\u00e9rgicos, tramadol, sumatript\u00e1n, triptanos, metabolismo de la serotonina, IMAOs, antipsic\u00f3ticos, antagonistas dopamin\u00e9rgicos, S\u00edndrome Serotonin\u00e9rgico, S\u00edndrome Neurol\u00e9ptico Maligno, s\u00edntomas."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "522ac278-4954-44be-bf8c-ffca1be2f1bc", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "a3cf722ec73bc3363a8ebb48fa6ed82fc4c945311da028e424989d1b5f5b89bf"}, "2": {"node_id": "38581f5e-de4f-43d9-9051-bec1e0402c29", "node_type": null, "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "c496fade0ab667bf370e31b8ad9afa38de9a0950936e88bc42b15a8a6ff76a5d"}}, "hash": "eadf913a5dd2a8113d26a409e651e8c7cebe9cf242488f3e87399389dcd5aa5d", "text": "Vortioxetina contiene como principio activo a la Vortioxetina. \u00c9ste pertenece a un grupo de medicamentos llamados antidepresivos. Vortioxetina se utiliza para tratar episodios de \ndepresi\u00f3n mayor en adultos. \nQU\u00c9 NECESITA SABER ANTES DE EMPEZAR A TOMAR VORTIOXETINA  \nNo tome este medicamento si:  \n- Es al\u00e9rgico (hipersensible) a la Vortioxetina o a cualquiera de los dem\u00e1s componentes \nde este medicamento.  \n- Se encuentra tomando otros medicamentos conocid os como inhibidores no selectivos \nde la monoaminooxidasa (IMAOs) o inhibidores selectivos de la MAO-A.  \nTENGA PRECAUCI\u00d3N  \nConsulte a su m\u00e9dico antes de empezar a tomar este medicamento si:  \n- Est\u00e1 tomando medicamentos con principios activos serotonin\u00e9rgicos ( p. ej., tramadol, \nsumatript\u00e1n y otros triptanos), medicamentos que afectan al metabolismo de la serotonina \n(incluyendo los IMAOs), antipsic\u00f3ticos y otros antagonistas dopamin\u00e9rgicos. La toma de estos \nmedicamentos junto con Vortioxetina puede aumentar el ri esgo, que ya presenta la \nadministraci\u00f3n solo con Vortioxetina sin a\u00f1adirle otro medicamento, de S\u00edndrome \nSerotonin\u00e9rgico (SS) o S\u00edndrome Neurol\u00e9ptico Maligno (SNM). Los s\u00edntomas del SS incluyen:", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "ddf203a9-df29-440d-900f-c84c894e57a1": {"__data__": {"id_": "ddf203a9-df29-440d-900f-c84c894e57a1", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment?\n2. How should Vortioxetine be used with caution in patients with a history of seizures or unstable epilepsy?\n3. What precautions should be taken when using Vortioxetine in patients with a history of mania or hypomania?", "prev_section_summary": "This section provides important information about Vortioxetine, including precautions, contraindications, and risks associated with its use for treating major depression in adults. The section mentions that Vortioxetine is an antidepressant medication and should not be taken by individuals who are allergic to Vortioxetine or any of its components, or who are taking certain other medications such as non-selective monoamine oxidase inhibitors (MAOIs) or selective MAO-A inhibitors. It also advises caution when taking Vortioxetine in combination with medications that affect serotonin metabolism, serotoninergic active substances, antipsychotics, and other dopaminergic antagonists, as this may increase the risk of serotonin syndrome (SS) or neuroleptic malignant syndrome (SNM). The symptoms of SS are not mentioned in the provided excerpt.", "section_summary": "The key topics of this section are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment, the caution needed when using Vortioxetine in patients with a history of seizures or unstable epilepsy, and the precautions to be taken when using Vortioxetine in patients with a history of mania or hypomania. The entities mentioned include changes in consciousness, autonomic instability, neuromuscular alterations, gastrointestinal symptoms, seizures, mania, and bleeding tendencies.", "excerpt_keywords": "cambios en el nivel de conciencia, agitaci\u00f3n, alucinaciones, estados de coma, inestabilidad aut\u00f3noma, taquicardia, presi\u00f3n arterial l\u00e1bil, hipertermia, alteraciones neuromusculares, hiperreflexia, descoordinaci\u00f3n, s\u00edntomas gastrointestinales, n\u00e1useas, v\u00f3mitos, diarrea, convulsiones, man\u00eda, tendencia a sangrar, hematomas f\u00e1cilmente."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "28a5a6dc0e892de294be38c592b06599316dc5606532d71ad09b255a59b330b4"}, "3": {"node_id": "92d383e2-5a2e-43f1-a706-3568521bc0ca", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "ab44c8156fce3b4638e0fa1e3a567aa3ee3aed9a1d8ddf95560c59ba69092e23"}}, "hash": "e674c968deacc17d5cdc75f5fb553efb7b983f56c0ed3be3a1eece597b6b6e05", "text": "cambios en el nivel de conciencia (p. ej., agitaci\u00f3n, alucina ciones, estados de coma), \ninestabilidad aut\u00f3noma (p. ej., taquicardia, presi\u00f3n arterial l\u00e1bil, hipertermia), alteraciones \nneuromusculares (p. ej., hiperreflexia, descoordinaci\u00f3n) y/o s\u00edntomas gastrointestinales (p. ej., \nn\u00e1useas, v\u00f3mitos o diarrea). Si esto  sucede, debe interrumpir inmediatamente el tratamiento \ncon Vortioxetina y buscar ayuda m\u00e9dica de inmediato. \n- Ha sufrido convulsiones. Su m\u00e9dico lo tratar\u00e1 con precauci\u00f3n si tiene antecedentes de \nconvulsiones o padece trastornos convulsivos inestables/ ep ilepsia. Las convulsiones son un \nriesgo potencial de este tipo de medicamentos. El tratamiento se debe interrumpir en \ncualquier paciente que experimente convulsiones o un aumento en su frecuencia. \n- Ha padecido man\u00eda. Vortioxetina  se debe usar con precauci\u00f3n en pacientes con \nantecedentes de man\u00eda/hipoman\u00eda y se debe interrumpir su administraci\u00f3n en cualquier \npaciente que entre en fase man\u00edaca.  \n- Tiene tendencia a sangrar o a que le aparezcan hematomas f\u00e1cilmente. Se han \nnotificado equimosis, p\u00farpura u otros acontecimientos hemorr\u00e1gicos, como sangrado \ngastrointestinal o ginecol\u00f3gico con el uso de este tipo de medicamentos. Se recomienda", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "92d383e2-5a2e-43f1-a706-3568521bc0ca": {"__data__": {"id_": "92d383e2-5a2e-43f1-a706-3568521bc0ca", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken for patients with a tendency to bleed easily when using Vortioxetine for treating major depression in adults?\n2. What should be considered for patients with low sodium levels in their blood when using Vortioxetine?\n3. What are the contraindications for using Vortioxetine in patients who are 65 years or older?", "prev_section_summary": "The key topics of this section are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment, the caution needed when using Vortioxetine in patients with a history of seizures or unstable epilepsy, and the precautions to be taken when using Vortioxetine in patients with a history of mania or hypomania. The entities mentioned include changes in consciousness, autonomic instability, neuromuscular alterations, gastrointestinal symptoms, seizures, mania, and bleeding tendencies.", "section_summary": "The key topics of this section are precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. The section mentions precautions for patients who have a tendency to bleed easily, patients with low sodium levels in their blood, patients who are 65 years or older, and patients with severe kidney or liver disease. The section also mentions the risk of manic episodes in patients who are prone to them.", "excerpt_keywords": "paciente, fase man\u00edaca, sangrado, hematomas, equimosis, p\u00farpura, acontecimientos hemorr\u00e1gicos, sangrado gastrointestinal, sangrado ginecol\u00f3gico, anticoagulantes, funci\u00f3n plaquetaria, antipsic\u00f3ticos at\u00edpicos, fenotiazinas, antidepresivos tric\u00edclicos, antiinflamatorios no esteroideos, \u00e1cido acetilsalic\u00edlico, niveles bajos de sodio, hiponatremia, edad avanzada, cirrosis hep\u00e1tica, enfermedad renal grave, enfermedad hep\u00e1tica grave, cirrosis, depresi\u00f3n, trastorno de ansiedad."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "28a5a6dc0e892de294be38c592b06599316dc5606532d71ad09b255a59b330b4"}, "2": {"node_id": "ddf203a9-df29-440d-900f-c84c894e57a1", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "e674c968deacc17d5cdc75f5fb553efb7b983f56c0ed3be3a1eece597b6b6e05"}, "3": {"node_id": "4be18c04-0d07-4a88-bc0c-339e92743fbd", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "de9a4071a5477e335fc1bed3228827b59230f9d012bffaaaec577e39e30498e3"}}, "hash": "ab44c8156fce3b4638e0fa1e3a567aa3ee3aed9a1d8ddf95560c59ba69092e23", "text": "paciente que entre en fase man\u00edaca.  \n- Tiene tendencia a sangrar o a que le aparezcan hematomas f\u00e1cilmente. Se han \nnotificado equimosis, p\u00farpura u otros acontecimientos hemorr\u00e1gicos, como sangrado \ngastrointestinal o ginecol\u00f3gico con el uso de este tipo de medicamentos. Se recomienda \nprecauci\u00f3n en pacientes tratados con anticoagulantes y/o medicamentos que se sabe que \nafectan a la  funci\u00f3n plaquetaria (p. ej., antipsic\u00f3ticos at\u00edpicos y fenotiazinas, la mayor\u00eda de los \nantidepresivos tric\u00edclicos, antiinflamatorios no esteroideos (AINE) y \u00e1cido acetilsalic\u00edlico (AAS)).  \n- Tiene niveles bajos de sodio en sangre. Se debe tener precauci\u00f3n en pacientes de \nriesgo, como pacientes de edad avanzada, pacientes con cirrosis hep\u00e1tica o pacientes tratados \nde manera simult\u00e1nea con medicamentos que se sabe causan hiponatremia. En pacientes con \nhiponatremia sintom\u00e1tica se debe considerar la interrupci\u00f3 n del tratamiento con Vortioxetina \ne instaurar una intervenci\u00f3n m\u00e9dica adecuada.  \n- Es una persona de 65 a\u00f1os o m\u00e1s.  \n- Padece una enfermedad renal grave.  \nPadece una enfermedad hep\u00e1tica grave, o una enfermedad hep\u00e1tica llamada cirrosis.  \nSi usted se encuentra  deprimido y/o sufre un trastorno de ansiedad, puede en algunas", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "4be18c04-0d07-4a88-bc0c-339e92743fbd": {"__data__": {"id_": "4be18c04-0d07-4a88-bc0c-339e92743fbd", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the precautions and contraindications for using Vortioxetine in the treatment of major depression in adults?\n2. What are the potential risks and side effects of taking Vortioxetine for the first time?\n3. How can individuals who are depressed or have an anxiety disorder seek help and support while taking Vortioxetine?", "prev_section_summary": "The key topics of this section are precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. The section mentions precautions for patients who have a tendency to bleed easily, patients with low sodium levels in their blood, patients who are 65 years or older, and patients with severe kidney or liver disease. The section also mentions the risk of manic episodes in patients who are prone to them.", "section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for the treatment of major depression in adults. The section mentions that Vortioxetine should not be used in certain situations, such as in individuals with severe kidney or liver disease. It also highlights the potential risk of increased thoughts of self-harm or suicide when taking Vortioxetine for the first time, especially in individuals who have previously experienced such thoughts or are young adults. The section emphasizes the importance of seeking help and support from a doctor or hospital if experiencing these thoughts.", "excerpt_keywords": "intervenci\u00f3n m\u00e9dica, persona mayor, enfermedad renal, enfermedad hep\u00e1tica, cirrosis, depresi\u00f3n, trastorno de ansiedad, pensamientos suicidas, Vortioxetina, efectos secundarios, medicamentos, dos semanas, adulto joven, pariente, amigo cercano, cambios de actitud"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "28a5a6dc0e892de294be38c592b06599316dc5606532d71ad09b255a59b330b4"}, "2": {"node_id": "92d383e2-5a2e-43f1-a706-3568521bc0ca", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "ab44c8156fce3b4638e0fa1e3a567aa3ee3aed9a1d8ddf95560c59ba69092e23"}, "3": {"node_id": "b913cbf2-eb53-4ead-bf7e-950de6c142da", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "e2e94726c2436696708d456be65a65c3e7b0be84a02babcab96c2f2c5a8a70d3"}}, "hash": "de9a4071a5477e335fc1bed3228827b59230f9d012bffaaaec577e39e30498e3", "text": "e instaurar una intervenci\u00f3n m\u00e9dica adecuada.  \n- Es una persona de 65 a\u00f1os o m\u00e1s.  \n- Padece una enfermedad renal grave.  \nPadece una enfermedad hep\u00e1tica grave, o una enfermedad hep\u00e1tica llamada cirrosis.  \nSi usted se encuentra  deprimido y/o sufre un trastorno de ansiedad, puede en algunas \nocasiones tener pensamientos en los que se haga da\u00f1o o se quite la vida. \u00c9stos pueden ir \naumentando al tomar Vortioxetina por primera vez, puesto que todos estos medicamentos \nrequieren un tiem po para empezar a hacer efecto, generalmente alrededor de unas dos \nsemanas, aunque en algunos casos podr\u00eda ser a\u00fan mayor. Usted ser\u00eda m\u00e1s propenso a tener este tipo de pensamientos: si usted previamente ha tenido pensamientos en los que se quita la \nvida o se hace da\u00f1o, o si usted es un adulto joven. Si en cualquier momento usted tiene \npensamientos en los que se hace da\u00f1o o se quita la vida, contacte con su m\u00e9dico o dir\u00edjase \ndirectamente a un hospital. Puede ser de ayuda para usted decirle a un pariente o un  amigo \ncercano que usted est\u00e1 deprimido o que tiene un trastorno de ansiedad y pedirle que lea este prospecto. Puede preguntarles si piensan que su depresi\u00f3n o trastorno de ansiedad ha \nempeorado, o si est\u00e1n preocupados por los cambios en su actitud.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "b913cbf2-eb53-4ead-bf7e-950de6c142da": {"__data__": {"id_": "b913cbf2-eb53-4ead-bf7e-950de6c142da", "embedding": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions and contraindications should be considered when using Vortioxetine for treating major depression in adults?\n2. Why is Vortioxetine not recommended for children and adolescents under 18 years old?\n3. What information is provided regarding the use of Vortioxetine during pregnancy and breastfeeding?", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for the treatment of major depression in adults. The section mentions that Vortioxetine should not be used in certain situations, such as in individuals with severe kidney or liver disease. It also highlights the potential risk of increased thoughts of self-harm or suicide when taking Vortioxetine for the first time, especially in individuals who have previously experienced such thoughts or are young adults. The section emphasizes the importance of seeking help and support from a doctor or hospital if experiencing these thoughts.", "section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. It also mentions that Vortioxetine is not recommended for children and adolescents under 18 years old due to a lack of information in this age group. Additionally, it provides information about the use of Vortioxetine during pregnancy and breastfeeding.", "excerpt_keywords": "hospital, depresi\u00f3n, trastorno de ansiedad, prospecto, pariente, amigo cercano, empeorado, cambios en la actitud, ni\u00f1os, adolescentes, vortioxetina, falta de informaci\u00f3n, embarazo, lactancia"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "28a5a6dc0e892de294be38c592b06599316dc5606532d71ad09b255a59b330b4"}, "2": {"node_id": "4be18c04-0d07-4a88-bc0c-339e92743fbd", "node_type": null, "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "de9a4071a5477e335fc1bed3228827b59230f9d012bffaaaec577e39e30498e3"}}, "hash": "e2e94726c2436696708d456be65a65c3e7b0be84a02babcab96c2f2c5a8a70d3", "text": "directamente a un hospital. Puede ser de ayuda para usted decirle a un pariente o un  amigo \ncercano que usted est\u00e1 deprimido o que tiene un trastorno de ansiedad y pedirle que lea este prospecto. Puede preguntarles si piensan que su depresi\u00f3n o trastorno de ansiedad ha \nempeorado, o si est\u00e1n preocupados por los cambios en su actitud.  \nNi\u00f1os y adolescentes: Vortioxetina no est\u00e1 recomendado en ni\u00f1os y adolescentes menores de \n18 a\u00f1os, debido a la falta de informaci\u00f3n en este grupo de edad.  \nEMBARAZO Y LACTANCIA", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "260e388b-8c94-4b17-b39e-5b122bbe644f": {"__data__": {"id_": "260e388b-8c94-4b17-b39e-5b122bbe644f", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and side effects of using Vortioxetine during pregnancy?\n2. What symptoms may be observed in a newborn if the mother takes Vortioxetine during the last 3 months of pregnancy?\n3. What should a pregnant woman do if her baby exhibits any of the mentioned symptoms after birth?", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. It also mentions that Vortioxetine is not recommended for children and adolescents under 18 years old due to a lack of information in this age group. Additionally, it provides information about the use of Vortioxetine during pregnancy and breastfeeding.", "section_summary": "The key topics of this section are the potential risks and side effects of using Vortioxetine during pregnancy. It mentions that Vortioxetine should not be used during pregnancy unless absolutely necessary, and if the benefits outweigh the possible risks to the fetus. It also states that if Vortioxetine is taken during the last 3 months of pregnancy, certain effects may be observed in the newborn, such as breathing problems, blue skin, seizures, and difficulty feeding. The section advises pregnant women to contact their doctor immediately if their baby exhibits any of these symptoms after birth. The key entities mentioned in this section are Vortioxetine, pregnancy, newborn, and the potential symptoms in the baby.", "excerpt_keywords": "embarazo, lactancia, m\u00e9dico, vortioxetina, riesgo, feto, reci\u00e9n nacido, problemas respiratorios, piel azulada, convulsiones, dificultad de alimentaci\u00f3n, v\u00f3mitos, az\u00facar bajo en sangre, m\u00fasculos r\u00edgidos, reflejos intensos, temblor, irritabilidad, letargia, somnolencia, dificultades para dormir, hipertensi\u00f3n."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "50e1d3a1c12cb22d3d1c47d1c0cf4a4726d4bf13773f87da8ebc4ed27c0f213b"}, "3": {"node_id": "ea7cff7b-7b84-49ce-8056-88d34c67e2ea", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "cee9353471cf98ec1b1e59fcb4d9a29e77a8c7116922aa51e4eeba6f40a6b633"}}, "hash": "0b3af772ddf2bddae91c03cfaf8d8e83a7bb158ac426ae11832faabb14f11d50", "text": "Si est\u00e1 embarazada o en periodo de lactancia, cree que podr\u00eda estar embarazada o tiene  \nintenci\u00f3n de quedarse embarazada, consulte a su m\u00e9dico antes de utilizar este medicamento. \nEmbarazo: Vortioxetina no se debe utilizar durante el embarazo a menos que su m\u00e9dico lo \nconsidere absolutamente necesario, y si los beneficios previstos superan el posible riesgo para \nel feto. Si toma este tipo de medicamentos durante los \u00faltimos 3 meses del embarazo, debe \nsaber que se pueden observar los siguientes efectos en el reci\u00e9n nacido: problemas para \nrespirar, piel azulada, apnea, convulsiones, cambios de la temperatura corporal, dificultad de \nalimentaci\u00f3n, v\u00f3mitos, az\u00facar bajo en sangre, m\u00fasculos r\u00edgidos o fl\u00e1cidos, reflejos intensos, \ntemblor, nerviosidad, irritabilidad, letargia, llanto continuo, somnolencia y dificultades para \ndormir. Estos s\u00edntomas comien zan normalmente durante las primeras 24 horas tras el \nnacimiento del beb\u00e9. Si su beb\u00e9 presenta cualquiera de estos s\u00edntomas, contacte con su m\u00e9dico inmediatamente.  \nA su vez, aseg\u00farese de que su m\u00e9dico sepa que usted est\u00e1 tomando este medicamento. \nCuando se toman durante el embarazo, especialmente en los \u00faltimos 3 meses de embarazo, \npueden aumentar el riesgo de una enfermedad grave en el beb\u00e9, llamada hipertensi\u00f3n", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "ea7cff7b-7b84-49ce-8056-88d34c67e2ea": {"__data__": {"id_": "ea7cff7b-7b84-49ce-8056-88d34c67e2ea", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and precautions associated with taking Vortioxetine during pregnancy?\n2. Can Vortioxetine pass into breast milk, and should it be avoided while breastfeeding?\n3. Does Vortioxetine have any impact on a person's ability to drive or operate machinery, and are there any specific precautions to take while using this medication?", "prev_section_summary": "The key topics of this section are the potential risks and side effects of using Vortioxetine during pregnancy. It mentions that Vortioxetine should not be used during pregnancy unless absolutely necessary, and if the benefits outweigh the possible risks to the fetus. It also states that if Vortioxetine is taken during the last 3 months of pregnancy, certain effects may be observed in the newborn, such as breathing problems, blue skin, seizures, and difficulty feeding. The section advises pregnant women to contact their doctor immediately if their baby exhibits any of these symptoms after birth. The key entities mentioned in this section are Vortioxetine, pregnancy, newborn, and the potential symptoms in the baby.", "section_summary": "The key topics of this section are the potential risks and precautions associated with taking Vortioxetine during pregnancy, the impact of Vortioxetine on breastfeeding, and the effects of Vortioxetine on a person's ability to drive or operate machinery. The entities mentioned include Vortioxetine, pregnancy, breastfeeding, hypotension, newborn, doctor, lactation, and medication.", "excerpt_keywords": "medicamento, embarazo, riesgo, hipertensi\u00f3n pulmonar persistente del reci\u00e9n nacido, lactancia, leche materna, interrupci\u00f3n, conducci\u00f3n, m\u00e1quinas, efectos secundarios, mareos, tratamiento, dosis, actividades, otros medicamentos"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "50e1d3a1c12cb22d3d1c47d1c0cf4a4726d4bf13773f87da8ebc4ed27c0f213b"}, "2": {"node_id": "260e388b-8c94-4b17-b39e-5b122bbe644f", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "0b3af772ddf2bddae91c03cfaf8d8e83a7bb158ac426ae11832faabb14f11d50"}, "3": {"node_id": "02c8e2f2-b066-4566-a57e-185c910672a5", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4cf763c0ba356a8ecfb3751bcf13dac137fd3afdf12510ebd96fe1041b417f1c"}}, "hash": "cee9353471cf98ec1b1e59fcb4d9a29e77a8c7116922aa51e4eeba6f40a6b633", "text": "A su vez, aseg\u00farese de que su m\u00e9dico sepa que usted est\u00e1 tomando este medicamento. \nCuando se toman durante el embarazo, especialmente en los \u00faltimos 3 meses de embarazo, \npueden aumentar el riesgo de una enfermedad grave en el beb\u00e9, llamada hipertensi\u00f3n \npulmonar persistente del reci\u00e9n nacido (HPPN), haciendo que el beb\u00e9 respire m\u00e1s r\u00e1pido y \nadopte un color azulado. Si esto le ocurre a su beb\u00e9, debe contactar con su m\u00e9dico \ninmediatamente.  \nLactancia: Se prev\u00e9 que los ingredientes de Vortioxetina pasen a la leche materna, por lo tanto, este medicamento no debe usarse durante la lactancia. Su m\u00e9dico de cidir\u00e1 si debe \ninterrumpir la lactancia o dejar de usar Vortioxetina, teniendo en cuenta el beneficio de la \nlactancia para el ni\u00f1o y el beneficio del tratamiento para usted.  \nCONDUCCI\u00d3N Y USO DE MAQUINAS  \nVortioxetina tiene poca o nula influencia sobre la ca pacidad de conducir o utilizar m\u00e1quinas. \nSin embargo, ya que se han reportado efectos secundarios tales como mareos, se recomienda \nprecauci\u00f3n durante este tipo de actividades al principio del tratamiento o al cambiar de dosis.  \nUSO DE OTROS MEDICAMENTOS  \nInforme a su m\u00e9dico si est\u00e1 tomando, ha tomado recientemente o podr\u00eda tener que tomar", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "02c8e2f2-b066-4566-a57e-185c910672a5": {"__data__": {"id_": "02c8e2f2-b066-4566-a57e-185c910672a5", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when starting or changing the dosage of Vortioxetine due to reported side effects such as dizziness?\n2. What other medications should be avoided while taking Vortioxetine, including those that can cause a decrease in sodium levels and irreversible or non-selective MAOIs?\n3. Is it safe to combine Vortioxetine with a weak reversible and non-selective MAOI like linezolid, and if necessary, what precautions should be taken?", "prev_section_summary": "The key topics of this section are the potential risks and precautions associated with taking Vortioxetine during pregnancy, the impact of Vortioxetine on breastfeeding, and the effects of Vortioxetine on a person's ability to drive or operate machinery. The entities mentioned include Vortioxetine, pregnancy, breastfeeding, hypotension, newborn, doctor, lactation, and medication.", "section_summary": "The key topics of this section are precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section discusses the precautions that should be taken when starting or changing the dosage of Vortioxetine due to reported side effects such as dizziness. It also mentions other medications that should be avoided while taking Vortioxetine, including those that can cause a decrease in sodium levels and irreversible or non-selective MAOIs. The section concludes by stating that combining Vortioxetine with a weak reversible and non-selective MAOI like linezolid is contraindicated, but if necessary, the added medication should be given at the minimum dose and closely monitored for serotonin syndrome.", "excerpt_keywords": "mareos, efectos secundarios, precauci\u00f3n, tratamiento, cambiar de dosis, medicamentos, niveles de sodio, IMAO irreversibles, fenelzina, iproniazida, isocarboxazida, nialamida, tranilcipromina, riesgo de SS, Vortioxetina, 14 d\u00edas, IMAO reversible, linezolid, contraindicada, monitorizaci\u00f3n estrecha."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "50e1d3a1c12cb22d3d1c47d1c0cf4a4726d4bf13773f87da8ebc4ed27c0f213b"}, "2": {"node_id": "ea7cff7b-7b84-49ce-8056-88d34c67e2ea", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "cee9353471cf98ec1b1e59fcb4d9a29e77a8c7116922aa51e4eeba6f40a6b633"}, "3": {"node_id": "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "3f8fab90b70fad820d86b8270f49d158755cc2bbde327840bbe160e1268e3853"}}, "hash": "4cf763c0ba356a8ecfb3751bcf13dac137fd3afdf12510ebd96fe1041b417f1c", "text": "Sin embargo, ya que se han reportado efectos secundarios tales como mareos, se recomienda \nprecauci\u00f3n durante este tipo de actividades al principio del tratamiento o al cambiar de dosis.  \nUSO DE OTROS MEDICAMENTOS  \nInforme a su m\u00e9dico si est\u00e1 tomando, ha tomado recientemente o podr\u00eda tener que tomar \ncualquier otro medicamento, incluso los adquiridos sin receta. En particular:  \n- Medicamentos que se sabe que causan disminuci\u00f3n en los niveles de sodio.  \n- IMAO irreversibles  y no selectivos: como fenelzina, iproniazida, isocarboxazida, \nnialamida, tranilcipromina (medicamentos para tratar la depresi\u00f3n). Debido al riesgo de SS no \ndebe tomar ninguno de estos medicamentos con Vortioxetina. Si ha tomado alguno de estos \nmedicamento s, debe esperar 14 d\u00edas antes de empezar a tomar Vortioxetina. Despu\u00e9s de \nsuspender Vortioxetina, debe esperar 14 d\u00edas antes de tomar cualquiera de estos medicamentos. \n- IMAO reversible y no selectivo: la combinaci\u00f3n de Vortioxetina con un IMAO reversible \ny no selectivo d\u00e9bil como linezolid (medicamento para tratar infecciones bacterianas) est\u00e1 \ncontraindicada. Si la combinaci\u00f3n fuera necesaria, el medicamento a\u00f1adido debe darse a la \ndosis m\u00ednima y bajo una monitorizaci\u00f3n estrecha del SS.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d": {"__data__": {"id_": "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d", "embedding": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What is the contraindication for combining Vortioxetine with a weak non-selective reversible MAOI like linezolid?\n2. What precautions should be taken when combining Vortioxetine with a reversible and selective MAO-A inhibitor like moclobemide?\n3. What is the recommended dosage and monitoring approach when combining Vortioxetine with an additional medication?", "prev_section_summary": "The key topics of this section are precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section discusses the precautions that should be taken when starting or changing the dosage of Vortioxetine due to reported side effects such as dizziness. It also mentions other medications that should be avoided while taking Vortioxetine, including those that can cause a decrease in sodium levels and irreversible or non-selective MAOIs. The section concludes by stating that combining Vortioxetine with a weak reversible and non-selective MAOI like linezolid is contraindicated, but if necessary, the added medication should be given at the minimum dose and closely monitored for serotonin syndrome.", "section_summary": "The key topics of this section are the contraindications and precautions for combining Vortioxetine with certain medications. The section specifically mentions the contraindication of combining Vortioxetine with a weak non-selective reversible MAOI like linezolid. It also discusses the precautions that should be taken when combining Vortioxetine with a reversible and selective MAO-A inhibitor like moclobemide. Additionally, the section mentions the recommended dosage and monitoring approach when combining Vortioxetine with an additional medication. The entities mentioned in this section include Vortioxetine, linezolid, moclobemide, and MAO-A.", "excerpt_keywords": "IMAO reversible, IMAO no selectivo, Vortioxetina, linezolid, contraindicaci\u00f3n, dosis m\u00ednima, monitorizaci\u00f3n estrecha, inhibidor de la MAO-A, selectivo, moclobemida, tratamiento, infecciones bacterianas, SS, combinaci\u00f3n, medicamento, reversible, monitorizaci\u00f3n."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "50e1d3a1c12cb22d3d1c47d1c0cf4a4726d4bf13773f87da8ebc4ed27c0f213b"}, "2": {"node_id": "02c8e2f2-b066-4566-a57e-185c910672a5", "node_type": null, "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4cf763c0ba356a8ecfb3751bcf13dac137fd3afdf12510ebd96fe1041b417f1c"}}, "hash": "3f8fab90b70fad820d86b8270f49d158755cc2bbde327840bbe160e1268e3853", "text": "- IMAO reversible y no selectivo: la combinaci\u00f3n de Vortioxetina con un IMAO reversible \ny no selectivo d\u00e9bil como linezolid (medicamento para tratar infecciones bacterianas) est\u00e1 \ncontraindicada. Si la combinaci\u00f3n fuera necesaria, el medicamento a\u00f1adido debe darse a la \ndosis m\u00ednima y bajo una monitorizaci\u00f3n estrecha del SS.  \n- Inhibidor de la M AO-A reversible y selectivo: la combinaci\u00f3n de Vortioxetina con un \ninhibidor de la MAO-A reversible y selectivo como moclobemida (medicamento para tratar la", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "1895eefa-e41f-40f0-88a5-dc52f54f61a2": {"__data__": {"id_": "1895eefa-e41f-40f0-88a5-dc52f54f61a2", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and precautions associated with combining Vortioxetine with irreversible and selective MAO-B inhibitors?\n2. Can the concurrent use of Vortioxetine and medications with serotoninergic effects, such as tramadol or sumatriptan, lead to serotonin syndrome?\n3. How does the use of Vortioxetine in combination with medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs, affect the risk of seizures?", "prev_section_summary": "The key topics of this section are the contraindications and precautions for combining Vortioxetine with certain medications. The section specifically mentions the contraindication of combining Vortioxetine with a weak non-selective reversible MAOI like linezolid. It also discusses the precautions that should be taken when combining Vortioxetine with a reversible and selective MAO-A inhibitor like moclobemide. Additionally, the section mentions the recommended dosage and monitoring approach when combining Vortioxetine with an additional medication. The entities mentioned in this section include Vortioxetine, linezolid, moclobemide, and MAO-A.", "section_summary": "The section discusses the potential risks and precautions associated with combining Vortioxetine with certain medications. The key topics include the combination of Vortioxetine with irreversible and selective MAO-B inhibitors, medications with serotoninergic effects, such as tramadol or sumatriptan, and medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs. The section also mentions the contraindication of combining Vortioxetine with St. John's Wort. The key entities mentioned are Vortioxetine, irreversible and selective MAO-B inhibitors, tramadol, sumatriptan, St. John's Wort, tricyclic antidepressants, and SSRIs.", "excerpt_keywords": "depresi\u00f3n, contraindicaci\u00f3n, combinaci\u00f3n, dosis m\u00ednima, monitorizaci\u00f3n cl\u00ednica, SS, inhibidores de la MAO-B, selegilina, rasagilina, enfermedad de Parkinson, precauci\u00f3n, medicamentos serotonin\u00e9rgicos, tramadol, sumatript\u00e1n, -tript\u00e1n, migra\u00f1a, Hierba de San Juan, Hypericum perforatum, reacciones adversas, umbral convulsivo, antidepresivos tric\u00edclicos, ISRS, IRSN."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "9e4a9e7bcf5017a6fac43ab8d0d08c61af6b5327f97ba9be32a60c0f1d828585"}, "3": {"node_id": "f1e2a382-4ccd-4a49-9eb6-36482b21e060", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4c01ae808cf9ba9098431907d512ce70f0cee296fc5c64cb5265cb74c3d4ceeb"}}, "hash": "6493cd35493399b37d1ea7ec36769be534a2c55fb5c8b27e23edbcf08e9cabdd", "text": "depresi\u00f3n) est\u00e1 contraindicada. Si la combinaci\u00f3n fuera necesaria, la adici\u00f3n del medicamento \ndeber \u00eda darse a dosis m\u00ednima y bajo estrecha monitorizaci\u00f3n cl\u00ednica para detectar la aparici\u00f3n \ndel SS.  \n- Inhibidores de la MAO-B irreversibles y selectivos: la combinaci\u00f3n de Vortioxetina con \ninhibidores de la MAO -B irreversibles, como la selegilina o la rasagi lina (medicamentos para \ntratar la enfermedad de Parkinson), se debe administrar con precauci\u00f3n. Si se utilizan de manera simult\u00e1nea, se debe estrechar la monitorizaci\u00f3n para detectar la aparici\u00f3n de SS.  \n- Medicamentos serotonin\u00e9rgicos: la administraci\u00f3n co njunta de medicamentos con \nefecto serotonin\u00e9rgico como tramadol (un fuerte analg\u00e9sico), sumatript\u00e1n y medicamentos \nsimilares con nombres de principios activos terminados en \u201c -tript\u00e1n\u201d (utilizados para tratar la \nmigra\u00f1a) puede provocar SS.  \n- Hierba de San J uan (Hypericum perforatum) (medicamento para tratar la depresi\u00f3n). El \nuso concomitante puede aumentar la incidencia de reacciones adversas, incluido el SS.  \n- Medicamentos que disminuyen el umbral convulsivo: Vortioxetina puede disminuir el \numbral convulsiv o. Se recomienda precauci\u00f3n cuando se utilice de manera simult\u00e1nea con \notros medicamentos capaces de disminuir este umbral: antidepresivos tric\u00edclicos, ISRS, IRSN", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "f1e2a382-4ccd-4a49-9eb6-36482b21e060": {"__data__": {"id_": "f1e2a382-4ccd-4a49-9eb6-36482b21e060", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when using Vortioxetine in combination with other medications that lower the seizure threshold?\n2. Is there any clinical experience regarding the concurrent administration of electroconvulsive therapy (ECT) and Vortioxetine?\n3. Are there any dosage adjustments required when Vortioxetine is used with inhibitors of CYP3A4, CYP2C9, and CYP2C19?\n\nHigher-level summary: This context provides information about precautions and potential interactions of Vortioxetine with other medications and therapies. It highlights the need for caution when using Vortioxetine with medications that lower the seizure threshold, lack of clinical experience with concurrent use of electroconvulsive therapy, and the absence of dosage adjustments when used with certain enzyme inhibitors.", "prev_section_summary": "The section discusses the potential risks and precautions associated with combining Vortioxetine with certain medications. The key topics include the combination of Vortioxetine with irreversible and selective MAO-B inhibitors, medications with serotoninergic effects, such as tramadol or sumatriptan, and medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs. The section also mentions the contraindication of combining Vortioxetine with St. John's Wort. The key entities mentioned are Vortioxetine, irreversible and selective MAO-B inhibitors, tramadol, sumatriptan, St. John's Wort, tricyclic antidepressants, and SSRIs.", "section_summary": "The key topics of this section are precautions and potential interactions of Vortioxetine with other medications and therapies. The section discusses the need for caution when using Vortioxetine with medications that lower the seizure threshold, the lack of clinical experience with concurrent use of electroconvulsive therapy, and the absence of dosage adjustments when used with certain enzyme inhibitors. The entities mentioned in this section include Vortioxetine, medications that lower the seizure threshold (such as tricyclic antidepressants, selective serotonin reuptake inhibitors, and neuroleptics), mefloquine, bupropion, tramadol, electroconvulsive therapy, inhibitors of CYP3A4, CYP2C9, and CYP2C19 (such as ketoconazole, fluconazole, and omeprazole), and poor metabolizers of CYP2D6.", "excerpt_keywords": "Vortioxetina, umbral convulsivo, medicamentos, precauci\u00f3n, antidepresivos tric\u00edclicos, ISRS, IRSN, neurol\u00e9pticos, mefloquina, bupropi\u00f3n, tramadol, terapia electroconvulsiva, inhibidores de la CYP3A4, CYP2C9, CYP2C19, ketoconazol, fluconazol, omeprazol, metabolizadores pobres, CYP2D6, inhibidor potente."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "9e4a9e7bcf5017a6fac43ab8d0d08c61af6b5327f97ba9be32a60c0f1d828585"}, "2": {"node_id": "1895eefa-e41f-40f0-88a5-dc52f54f61a2", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "6493cd35493399b37d1ea7ec36769be534a2c55fb5c8b27e23edbcf08e9cabdd"}, "3": {"node_id": "9452c1be-1edb-456a-a85a-43cb62f83b4e", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4fc35df3be392d92a23bce5c184a529d65b575c1ef9bf08b19503fb0e2daad20"}}, "hash": "4c01ae808cf9ba9098431907d512ce70f0cee296fc5c64cb5265cb74c3d4ceeb", "text": "- Medicamentos que disminuyen el umbral convulsivo: Vortioxetina puede disminuir el \numbral convulsiv o. Se recomienda precauci\u00f3n cuando se utilice de manera simult\u00e1nea con \notros medicamentos capaces de disminuir este umbral: antidepresivos tric\u00edclicos, ISRS, IRSN \n(fluoxetina, paroxetina), neurol\u00e9pticos (fenotiazinas, tioxantenos y butirofenonas), mefloqui na \n(medicamento para prevenir y tratar la malaria), bupropi\u00f3n (medicamento para tratar la depresi\u00f3n tambi\u00e9n utilizado para dejar de fumar) y tramadol. Por favor hable con su m\u00e9dico si \nusted est\u00e1 tomando alguno de los medicamentos mencionados, ya que su m\u00e9d ico necesita \nsaber si usted tiene riesgo de sufrir convulsiones.  \n- Terapia electroconvulsiva ( TEC): no hay experiencia cl\u00ednica sobre la administraci\u00f3n \nconcomitante de TEC y Vortioxetina, por lo que se recomienda precauci\u00f3n.  \n- Inhibidores de la CYP3A4, la CYP2C9 y la CYP2C19 como ketoconazol, fluconazol, \nomeprazol. No se requiere un ajuste de la dosis. \n- Interacciones en metabolizadores pobres de la CYP2D6: Seg\u00fan la respuesta individual \ndel paciente, se puede considerar una dosis m\u00e1s baja de Vortioxetina si  se administra de forma \nconjunta un inhibidor potente de la CYP3A4 (como el itraconazol, voriconazol, claritromicina,", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "9452c1be-1edb-456a-a85a-43cb62f83b4e": {"__data__": {"id_": "9452c1be-1edb-456a-a85a-43cb62f83b4e", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when combining Vortioxetine with anticoagulants or antiaggregants?\n2. Are there any potential interactions between Vortioxetine and omeprazole?\n3. How does the administration of Vortioxetine affect the levels of hormones in the body when taken with an oral contraceptive?", "prev_section_summary": "The key topics of this section are precautions and potential interactions of Vortioxetine with other medications and therapies. The section discusses the need for caution when using Vortioxetine with medications that lower the seizure threshold, the lack of clinical experience with concurrent use of electroconvulsive therapy, and the absence of dosage adjustments when used with certain enzyme inhibitors. The entities mentioned in this section include Vortioxetine, medications that lower the seizure threshold (such as tricyclic antidepressants, selective serotonin reuptake inhibitors, and neuroleptics), mefloquine, bupropion, tramadol, electroconvulsive therapy, inhibitors of CYP3A4, CYP2C9, and CYP2C19 (such as ketoconazole, fluconazole, and omeprazole), and poor metabolizers of CYP2D6.", "section_summary": "The key topics of this section are precautions and potential interactions of Vortioxetine with other medications. The section mentions precautions when combining Vortioxetine with anticoagulants or antiaggregants, potential interactions with omeprazole, the effect of Vortioxetine on hormone levels when taken with an oral contraceptive, and the caution needed when using Vortioxetine with lithium and tryptophan. The entities mentioned in this section include anticoagulants, antiaggregants, omeprazole, CYP2D6, CYP3A4, CYP2C9, warfarin, dipiridamol, fenprocum\u00f3n, \u00e1cido acetilsalic\u00edlico, diazepam, hormones, etinil estradiol, levonorgestrel, lithium, and tryptophan.", "excerpt_keywords": "omeprazol, ajuste de dosis, interacciones, metabolizadores pobres, CYP2D6, inhibidor potente, CYP3A4, itraconazol, voriconazol, claritromicina, telitromicina, nefazodona, conivaptan, inhibidores de la proteasa del VIH, CYP2C9, fluconazol, amiodarona, anticoagulantes, antiagregantes plaquetarios, warfarina, dipiridamol, fenprocum\u00f3n, \u00e1cido acetilsalic\u00edlico, hemorragia, diazepam, funci\u00f3n cognitiva, hormonas sexuales, anticonceptivo oral combinado, litio, tript\u00f3fano, precauci\u00f3n."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "9e4a9e7bcf5017a6fac43ab8d0d08c61af6b5327f97ba9be32a60c0f1d828585"}, "2": {"node_id": "f1e2a382-4ccd-4a49-9eb6-36482b21e060", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4c01ae808cf9ba9098431907d512ce70f0cee296fc5c64cb5265cb74c3d4ceeb"}, "3": {"node_id": "9b2d3a5b-c571-40fe-9202-26acd06c2564", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "668b4645e65ea2ed49e0ff9332f7fa4aea0f2815de6a5585607d5a0d6ffcebba"}}, "hash": "4fc35df3be392d92a23bce5c184a529d65b575c1ef9bf08b19503fb0e2daad20", "text": "omeprazol. No se requiere un ajuste de la dosis. \n- Interacciones en metabolizadores pobres de la CYP2D6: Seg\u00fan la respuesta individual \ndel paciente, se puede considerar una dosis m\u00e1s baja de Vortioxetina si  se administra de forma \nconjunta un inhibidor potente de la CYP3A4 (como el itraconazol, voriconazol, claritromicina, \ntelitromicina, nefazodona, conivaptan, y muchos de los inhibidores de la proteasa del VIH) o de \nla CYP2C9 (como fluconazol y amiodarona) e n pacientes metabolizadores lentos de la CYP2D6.  \n- Anticoagulantes y antiagregantes plaquetarios: se debe tener precauci\u00f3n al combinar \nla Vortioxetina  con anticoagulantes o antiagregantes plaquetarios orales como warfarina, \ndipiridamol, fenprocum\u00f3n, \u00e1cido acetilsalic\u00edlico, debido al potencial aumento del riesgo de hemorragia.  \n- La administraci\u00f3n conjunta con diazepam parece no alterar la funci\u00f3n cogniti va. \n- No se observaron cambios en los niveles de hormonas sexuales despu\u00e9s de la \nadministraci\u00f3n conjunta de Vortioxetina con el anticonceptivo oral combinado (etinil estradiol \n30 \u00b5g/ levonorgestrel 150 \u00b5g).  \n- Litio (medicamento para tratar la depresi\u00f3n y l os trastornos mentales) y tript\u00f3fano: el \nuso concomitante de Vortioxetina con estos medicamentos se debe realizar con precauci\u00f3n.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "9b2d3a5b-c571-40fe-9202-26acd06c2564": {"__data__": {"id_": "9b2d3a5b-c571-40fe-9202-26acd06c2564", "embedding": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the precautions and risks associated with combining Vortioxetine with the oral contraceptive pill containing ethinyl estradiol and levonorgestrel?\n2. How should Vortioxetine be used cautiously when taken together with lithium and tryptophan, medications used to treat depression and mental disorders?\n3. Is there any specific information regarding the administration of Vortioxetine with food and beverages?", "prev_section_summary": "The key topics of this section are precautions and potential interactions of Vortioxetine with other medications. The section mentions precautions when combining Vortioxetine with anticoagulants or antiaggregants, potential interactions with omeprazole, the effect of Vortioxetine on hormone levels when taken with an oral contraceptive, and the caution needed when using Vortioxetine with lithium and tryptophan. The entities mentioned in this section include anticoagulants, antiaggregants, omeprazole, CYP2D6, CYP3A4, CYP2C9, warfarin, dipiridamol, fenprocum\u00f3n, \u00e1cido acetilsalic\u00edlico, diazepam, hormones, etinil estradiol, levonorgestrel, lithium, and tryptophan.", "section_summary": "The section discusses the precautions and risks associated with combining Vortioxetine with the oral contraceptive pill containing ethinyl estradiol and levonorgestrel. It also mentions the cautious use of Vortioxetine when taken together with lithium and tryptophan, medications used to treat depression and mental disorders. Additionally, there is information regarding the administration of Vortioxetine with food and beverages.", "excerpt_keywords": "administraci\u00f3n conjunta, Vortioxetina, anticonceptivo oral combinado, etinil estradiol, levonorgestrel, litio, tript\u00f3fano, depresi\u00f3n, trastornos mentales, precauci\u00f3n, alimentos, bebidas."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "9e4a9e7bcf5017a6fac43ab8d0d08c61af6b5327f97ba9be32a60c0f1d828585"}, "2": {"node_id": "9452c1be-1edb-456a-a85a-43cb62f83b4e", "node_type": null, "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "4fc35df3be392d92a23bce5c184a529d65b575c1ef9bf08b19503fb0e2daad20"}}, "hash": "668b4645e65ea2ed49e0ff9332f7fa4aea0f2815de6a5585607d5a0d6ffcebba", "text": "administraci\u00f3n conjunta de Vortioxetina con el anticonceptivo oral combinado (etinil estradiol \n30 \u00b5g/ levonorgestrel 150 \u00b5g).  \n- Litio (medicamento para tratar la depresi\u00f3n y l os trastornos mentales) y tript\u00f3fano: el \nuso concomitante de Vortioxetina con estos medicamentos se debe realizar con precauci\u00f3n.  \nTOMA DE VORTIOXETINA CON ALIMENTOS Y BEBIDAS", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "f0c7c151-f604-4ab6-b62d-fb97e74e7ee4": {"__data__": {"id_": "f0c7c151-f604-4ab6-b62d-fb97e74e7ee4", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the possible side effects of taking Vortioxetine and when do they typically occur?\n2. Can Vortioxetine be taken with alcohol?\n3. What are the precautions and contraindications for using Vortioxetine to treat major depression in adults?", "prev_section_summary": "The section discusses the precautions and risks associated with combining Vortioxetine with the oral contraceptive pill containing ethinyl estradiol and levonorgestrel. It also mentions the cautious use of Vortioxetine when taken together with lithium and tryptophan, medications used to treat depression and mental disorders. Additionally, there is information regarding the administration of Vortioxetine with food and beverages.", "section_summary": "The section discusses the precautions, contraindications, and possible side effects of taking Vortioxetine, a medication used to treat major depression in adults. It mentions that the tablets can be taken with or without food, but it is not recommended to combine the medication with alcohol. The possible side effects are generally mild or moderate and occur within the first two weeks of treatment. Some of the common side effects include nausea, diarrhea, constipation, vomiting, dizziness, itching, abnormal dreams, and flushing of the skin. It also mentions that low levels of sodium in the blood may occur, which can cause symptoms such as dizziness and weakness.", "excerpt_keywords": "Vortioxetina, comprimidos, alimentos, combinaci\u00f3n, alcohol, efectos adversos, n\u00e1useas, diarrea, estre\u00f1imiento, v\u00f3mitos, mareo, prurito, picor, sue\u00f1os anormales, rubefacci\u00f3n, enrojecimiento de la piel, sudores nocturnos, niveles bajos de sodio en sangre, sensaci\u00f3n de mareo, debilidad."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "d69ca6ed-f926-4841-a592-7fc400f9002f", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "15672c146b9f69e5a1a0a6e3c64bcd7f135956b6d2acd2b520e18f97afa75470"}, "3": {"node_id": "c44684d7-a3f9-4d0e-a0bf-539a90eb853b", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "e45eeff75717c2d7b5cf0b6036dfc0b00ad01c1967a360a5ff041e712791f643"}}, "hash": "ed84bb54a758054a23657e4e2676944504537e1d8962a018494531ec8e6f1f1c", "text": "Los comprimidos de Vortioxetina se pueden tomar con o sin alimentos. No se aconseja la \ncombinaci\u00f3n de este medicamento con alcohol.  \nPOSIBLES EFECTOS ADVERSOS  \nAl igual que todos los medicamentos, este medicamento puede producir efectos adversos, \naunque no todas las personas los sufran.  \nLos efectos adversos observados fueron en su mayor\u00ed a leves o moderados y se produjeron en \nlas primeras dos semanas de tratamiento. Estos efectos fueron, por lo general, transitorios y \nno requirieron la suspensi\u00f3n del tratamiento.  \nSe han observado los siguientes efectos adversos con las frecuencias que se i ndican:  \n- Muy frecuentes (pueden afectar a m\u00e1s de 1 de cada 10 personas): n\u00e1useas.  \n- Frecuentes (pueden afectar hasta 1 de cada 10 personas): diarrea, estre\u00f1imiento, \nv\u00f3mitos; mareo; prurito incluyendo picor en todo el cuerpo; sue\u00f1os anormales.  \n- Poco frecu entes (pueden afectar hasta 1 de cada 100 personas): rubefacci\u00f3n \n(enrojecimiento de la piel); sudores nocturnos.  \n- Frecuencia no conocida (no puede estimarse a partir de los datos disponibles): niveles \nbajos de sodio en sangre (algunos de los s\u00edntomas pued en ser sensaci\u00f3n de mareo, debilidad,", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "c44684d7-a3f9-4d0e-a0bf-539a90eb853b": {"__data__": {"id_": "c44684d7-a3f9-4d0e-a0bf-539a90eb853b", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential side effects of taking Vortioxetine for treating major depression in adults?\n2. What are the rare side effects of Vortioxetine, such as low sodium levels in the blood and serotonin syndrome?\n3. What are the risks associated with taking a 20 mg dose of Vortioxetine, including sexual dysfunction and increased risk of bone fractures in patients aged 50 or older?", "prev_section_summary": "The section discusses the precautions, contraindications, and possible side effects of taking Vortioxetine, a medication used to treat major depression in adults. It mentions that the tablets can be taken with or without food, but it is not recommended to combine the medication with alcohol. The possible side effects are generally mild or moderate and occur within the first two weeks of treatment. Some of the common side effects include nausea, diarrhea, constipation, vomiting, dizziness, itching, abnormal dreams, and flushing of the skin. It also mentions that low levels of sodium in the blood may occur, which can cause symptoms such as dizziness and weakness.", "section_summary": "The key topics of this section are the potential side effects of taking Vortioxetine for treating major depression in adults. The section mentions common side effects such as skin redness and night sweats, as well as rare side effects including low sodium levels in the blood, serotonin syndrome, allergic reactions, and excessive or unexplained bleeding. It also highlights the risks associated with taking a 20 mg dose of Vortioxetine, such as sexual dysfunction and an increased risk of bone fractures in patients aged 50 or older. The section advises individuals to consult their doctor if they experience any adverse effects.", "excerpt_keywords": "rubefacci\u00f3n, enrojecimiento de la piel, sudores nocturnos, niveles bajos de sodio en sangre, sensaci\u00f3n de mareo, debilidad, confusi\u00f3n, somnolencia, cansancio, n\u00e1useas, v\u00f3mitos, S\u00edndrome Serotonin\u00e9rgico, reacciones al\u00e9rgicas, hinchaz\u00f3n, dificultad para respirar, dificultad para tragar, descenso repentino de la presi\u00f3n arterial, urticaria, erupci\u00f3n, sangrado excesivo, contusi\u00f3n, hematomas, hemorragia nasal, sangrado gastrointestinal, sangrado vaginal, disfunci\u00f3n sexual, TESD, riesgo de fracturas \u00f3seas, medicamento, efecto adverso, m\u00e9dico"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "d69ca6ed-f926-4841-a592-7fc400f9002f", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "15672c146b9f69e5a1a0a6e3c64bcd7f135956b6d2acd2b520e18f97afa75470"}, "2": {"node_id": "f0c7c151-f604-4ab6-b62d-fb97e74e7ee4", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "ed84bb54a758054a23657e4e2676944504537e1d8962a018494531ec8e6f1f1c"}, "3": {"node_id": "04bfad7a-0c57-4de6-bd62-1ddf54451460", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "d998cff15e5aece521f7afc83b0441369edb495869b95d815b9dde7d55f7c2ab"}}, "hash": "e45eeff75717c2d7b5cf0b6036dfc0b00ad01c1967a360a5ff041e712791f643", "text": "- Poco frecu entes (pueden afectar hasta 1 de cada 100 personas): rubefacci\u00f3n \n(enrojecimiento de la piel); sudores nocturnos.  \n- Frecuencia no conocida (no puede estimarse a partir de los datos disponibles): niveles \nbajos de sodio en sangre (algunos de los s\u00edntomas pued en ser sensaci\u00f3n de mareo, debilidad, \nconfusi\u00f3n, somnolencia o mucho cansancio, o bien tener n\u00e1useas o v\u00f3mitos; otros s\u00edntomas m\u00e1s graves son desmayos, convulsiones o ca\u00eddas); S\u00edndrome Serotonin\u00e9rgico; reacciones \nal\u00e9rgicas (reacciones anafil\u00e1cticas), que pueden ser graves, y provocar hinchaz\u00f3n de la cara, los \nlabios, la lengua o la garganta; dificultad para respirar o tragar, y/o descenso repentino de la \npresi\u00f3n arterial (que puede hacer que se sienta mareado o aturdido); urticaria, erupci\u00f3n; \nsangrado excesivo o inexplicable (incluyendo contusi\u00f3n, hematomas, hemorragia nasal, \nsangrado gastrointestinal y vaginal).  \nPor otro lado, la dosis de Vortioxetina de 20 mg se asoci\u00f3 con un incremento en disfunci\u00f3n \nsexual (TESD). A su vez, se ha observado un incremento del riesgo de fracturas \u00f3seas en \npacientes que toman este tipo de medicamentos y tienen 50 a\u00f1os o m\u00e1s. \nSi experimenta cualquier tipo de efecto adverso, consulte a su m\u00e9dico, incluso si se trata de", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "04bfad7a-0c57-4de6-bd62-1ddf54451460": {"__data__": {"id_": "04bfad7a-0c57-4de6-bd62-1ddf54451460", "embedding": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the recommended dosages of Vortioxetine for adults under 65 years old and for elderly patients?\n2. Are there any specific precautions or contraindications for taking Vortioxetine in patients over 50 years old?\n3. What are the potential side effects of Vortioxetine and when should a patient consult their doctor about them?", "prev_section_summary": "The key topics of this section are the potential side effects of taking Vortioxetine for treating major depression in adults. The section mentions common side effects such as skin redness and night sweats, as well as rare side effects including low sodium levels in the blood, serotonin syndrome, allergic reactions, and excessive or unexplained bleeding. It also highlights the risks associated with taking a 20 mg dose of Vortioxetine, such as sexual dysfunction and an increased risk of bone fractures in patients aged 50 or older. The section advises individuals to consult their doctor if they experience any adverse effects.", "section_summary": "The key topics of this section are the recommended dosages of Vortioxetine for adults under 65 years old and for elderly patients, precautions and contraindications for taking Vortioxetine in patients over 50 years old, and potential side effects of Vortioxetine. The key entities mentioned are Vortioxetine, adults under 65 years old, elderly patients, and patients over 50 years old.", "excerpt_keywords": "Vortioxetina, medicamento, efectos adversos, prospecto, dosis, administraci\u00f3n, agua, alimentos, respuesta al tratamiento, edad avanzada, precauci\u00f3n, pacientes, incremento del riesgo, fracturas \u00f3seas, m\u00e9dico, consulte, posibles efectos adversos, comprimidos, 65 a\u00f1os o m\u00e1s."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "d69ca6ed-f926-4841-a592-7fc400f9002f", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "15672c146b9f69e5a1a0a6e3c64bcd7f135956b6d2acd2b520e18f97afa75470"}, "2": {"node_id": "c44684d7-a3f9-4d0e-a0bf-539a90eb853b", "node_type": null, "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "e45eeff75717c2d7b5cf0b6036dfc0b00ad01c1967a360a5ff041e712791f643"}}, "hash": "d998cff15e5aece521f7afc83b0441369edb495869b95d815b9dde7d55f7c2ab", "text": "sexual (TESD). A su vez, se ha observado un incremento del riesgo de fracturas \u00f3seas en \npacientes que toman este tipo de medicamentos y tienen 50 a\u00f1os o m\u00e1s. \nSi experimenta cualquier tipo de efecto adverso, consulte a su m\u00e9dico, incluso si se trata de \nposibles efectos adversos que no aparecen en este prospecto.  \nC\u00d3MO TOMAR VORTIOXETINA \nSiga exactamente las instrucciones de administraci\u00f3n de este medicamento indicadas por su \nm\u00e9dico. En caso de duda, consulte de nuevo con \u00e9l.  \nLos comprimidos se deben tomar con un poco de agua, con o sin alimentos.  \nPosolog\u00eda:  \nAdulo s menores a 65 a\u00f1os: La dosis recomendada de Vortioxetina es 10 mg una vez al d\u00eda. En \nfunci\u00f3n de su respuesta al tratamiento, su m\u00e9dico puede aumentar la dosis hasta un m\u00e1ximo \nde 20 mg de Vortioxetina al d\u00eda o reducirla hasta un m\u00ednimo de 5 mg de Vortioxetina al d\u00eda.  \nPacientes de edad avanzada (65 a\u00f1os o m\u00e1s): Como dosis inicial se debe utilizar siempre la \ndosis eficaz m\u00e1s baja de 5 mg de Vortioxetina una vez al d\u00eda. Se debe tener precauci\u00f3n cuando \nse traten pacientes de \u2265 65 a\u00f1os de edad con dosis superior es a 10 mg de Vortioxetina una vez", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "3dadae44-9de5-46c3-8b83-46f87c49d1c8": {"__data__": {"id_": "3dadae44-9de5-46c3-8b83-46f87c49d1c8", "embedding": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when treating patients with renal or hepatic insufficiency with Vortioxetine?\n2. How should the dosage of Vortioxetine be adjusted when combined with potent inhibitors or inducers of the cytochrome P450 enzyme?\n3. How long should Vortioxetine be taken and for how long after feeling better should the treatment continue?", "prev_section_summary": "The key topics of this section are the recommended dosages of Vortioxetine for adults under 65 years old and for elderly patients, precautions and contraindications for taking Vortioxetine in patients over 50 years old, and potential side effects of Vortioxetine. The key entities mentioned are Vortioxetine, adults under 65 years old, elderly patients, and patients over 50 years old.", "section_summary": "The key topics of this section are precautions and risks associated with the use of Vortioxetine in patients with renal or hepatic insufficiency, dosage adjustment when combined with potent inhibitors or inducers of the cytochrome P450 enzyme, and the recommended duration of treatment. The entities mentioned include Vortioxetine, renal or hepatic insufficiency, inhibitors of the cytochrome P450 enzyme, and inducers of the cytochrome P450 enzyme.", "excerpt_keywords": "ajuste de dosis, funci\u00f3n renal, funci\u00f3n hep\u00e1tica, insuficiencia renal, insuficiencia hep\u00e1tica, precauci\u00f3n, inhibidores del citocromo P450, dosis m\u00e1s baja, inhibidor potente, inductores del citocromo P450, ajuste de dosis, duraci\u00f3n del tratamiento, m\u00e9dico, mejor\u00eda, olvido, Vortioxetina."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "c0bbc515441081827095209e6bf7bcbb7aaed8898c2b875e739b543096639dd9"}, "3": {"node_id": "31dd326c-ab65-4fbc-baa7-2bd9a7365b42", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "0f1aeb691038116e628d30c8c63085f7e8b0ae57d06ef7cea43dde510df0150d"}}, "hash": "63819555553cbe1d1f6ec4b4b29545b7c8f46dd5a49943d47b1bfc27ee6a6e70", "text": "al d\u00eda, ya que los datos son limitados. Insuficiencia renal o hep\u00e1tica: No se requiere un ajuste \nde la dosis sobre la base de la funci\u00f3n renal o hep\u00e1tica. Sin embargo, dado que los sujetos con \ninsuficiencia renal o hep\u00e1ti ca son vulnerables y dado que los datos sobre el uso de Vortioxetina \nen estas subpoblaciones son limitados, se debe tener precauci\u00f3n cuando se traten estos pacientes.  \nInhibidores del citocromo P450: Seg\u00fan la respuesta individual del paciente, se puede \ncons iderar una dosis m\u00e1s baja de Vortioxetina si se a\u00f1ade un inhibidor potente de la CYP2D6 \n(p. ej., bupropi\u00f3n, quinidina, fluoxetina, paroxetina) al tratamiento con Vortioxetina.  \nInductores del citocromo P450: Seg\u00fan la respuesta individual del paciente, se pu ede \nconsiderar un ajuste de la dosis de Vortioxetina si se a\u00f1ade un inductor del citocromo P450 de \namplio espectro (p. ej., rifampicina, carbamazepina, fenito\u00edna) al tratamiento con Vortioxetina. \nDuraci\u00f3n del tratamiento: Tome Vortioxetina durante el tiempo que le indique su m\u00e9dico. \nContin\u00fae tom\u00e1ndolo, aunque tarde cierto tiempo en empezar a notar una mejor\u00eda en su \nestado. Debe continuar con el tratamiento durante al menos 6 meses despu\u00e9s de sentirse bien \nde nuevo.  \nSI OLVID\u00d3 TOMAR VORTIOXETINA", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "31dd326c-ab65-4fbc-baa7-2bd9a7365b42": {"__data__": {"id_": "31dd326c-ab65-4fbc-baa7-2bd9a7365b42", "embedding": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. How long should Vortioxetine be taken for treating major depression in adults?\n2. What should be done if a dose of Vortioxetine is missed?\n3. What are the symptoms of an overdose of Vortioxetine and what should be done in case of overdose?", "prev_section_summary": "The key topics of this section are precautions and risks associated with the use of Vortioxetine in patients with renal or hepatic insufficiency, dosage adjustment when combined with potent inhibitors or inducers of the cytochrome P450 enzyme, and the recommended duration of treatment. The entities mentioned include Vortioxetine, renal or hepatic insufficiency, inhibitors of the cytochrome P450 enzyme, and inducers of the cytochrome P450 enzyme.", "section_summary": "The key topics of this section are the duration of treatment with Vortioxetine for major depression in adults, what to do if a dose is missed, and the symptoms and actions to take in case of an overdose. The entities mentioned include Vortioxetine, the medication being discussed, and the various symptoms of an overdose such as dizziness, nausea, diarrhea, and skin redness.", "excerpt_keywords": "tratamiento, Vortioxetina, m\u00e9dico, duraci\u00f3n, mejor\u00eda, estado, tomar, olvid\u00f3, dosis, interrumpir, consultarlo, gradual, duda, uso, medicamento, sobredosis, ingesti\u00f3n accidental, centro de asistencia m\u00e9dica, Servicio de Informaci\u00f3n Toxicol\u00f3gica, s\u00edntomas, mareo postural, n\u00e1useas, diarrea, molestias estomacales, picor, somnolencia, rubefacci\u00f3n, enrojecimiento de la piel"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "c0bbc515441081827095209e6bf7bcbb7aaed8898c2b875e739b543096639dd9"}, "2": {"node_id": "3dadae44-9de5-46c3-8b83-46f87c49d1c8", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "63819555553cbe1d1f6ec4b4b29545b7c8f46dd5a49943d47b1bfc27ee6a6e70"}, "3": {"node_id": "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "f573c9345e08f7bcb835017ad58a31d27b888fd06f2ffd594cba49d979d81690"}}, "hash": "0f1aeb691038116e628d30c8c63085f7e8b0ae57d06ef7cea43dde510df0150d", "text": "Duraci\u00f3n del tratamiento: Tome Vortioxetina durante el tiempo que le indique su m\u00e9dico. \nContin\u00fae tom\u00e1ndolo, aunque tarde cierto tiempo en empezar a notar una mejor\u00eda en su \nestado. Debe continuar con el tratamiento durante al menos 6 meses despu\u00e9s de sentirse bien \nde nuevo.  \nSI OLVID\u00d3 TOMAR VORTIOXETINA \nTome la sigui ente dosis a la hora habitual. No tome una dosis doble para compensar las dosis \nolvidadas.  \nSI INTERRUMPE EL TRATAMIENTO CON VORTIOXETINA \nNo deje de tomar Vortioxetina sin consultarlo a su m\u00e9dico. Cuando este indicada su \ninterrupci\u00f3n, no se requiere una dis minuci\u00f3n gradual de la dosis.  \nSi tiene cualquier otra duda sobre el uso de este medicamento, pregunte a su m\u00e9dico.  \nSI TOMA M\u00c1S VORTIOXETINA DEL QUE DEBIERA  \nEn caso de sobredosis o ingesti\u00f3n accidental, consulte inmediatamente al centro de asistencia m\u00e9dica m\u00e1s cercano o al Servicio de Informaci\u00f3n Toxicol\u00f3gica de referencia indicando el \nmedicamento y la cantidad ingerida. Se recomienda llevar el envase y el prospecto del \nmedicamento al profesional sanitario.  \nLos s\u00edntomas en caso de sobredosi s son: mareo postural, n\u00e1useas, diarrea, molestias en el \nest\u00f3mago, picor en todo el cuerpo, somnolencia y rubefacci\u00f3n (enrojecimiento de la piel).", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e": {"__data__": {"id_": "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e", "embedding": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the symptoms of an overdose of Vortioxetine and how should it be treated?\n2. What are the different presentations of Vortioxetine available and how many tablets are included in each package?\n3. What precautions should be taken when taking Vortioxetine and what are the contraindications for its use?", "prev_section_summary": "The key topics of this section are the duration of treatment with Vortioxetine for major depression in adults, what to do if a dose is missed, and the symptoms and actions to take in case of an overdose. The entities mentioned include Vortioxetine, the medication being discussed, and the various symptoms of an overdose such as dizziness, nausea, diarrhea, and skin redness.", "section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section also mentions the symptoms of an overdose of Vortioxetine and how it should be treated. Additionally, it provides information about the different presentations of Vortioxetine available and the number of tablets included in each package. The entities mentioned in this section include Vortioxetine, overdose symptoms, treatment, precautions, contraindications, and different presentations of the medication.", "excerpt_keywords": "medicamento, cantidad ingerida, envase, prospecto, profesional sanitario, s\u00edntomas, sobredosis, mareo postural, n\u00e1useas, diarrea, molestias estomacales, picor en el cuerpo, somnolencia, rubefacci\u00f3n, convulsiones, S\u00edndrome Serotonin\u00e9rgico, tratamiento, monitorizaci\u00f3n, seguimiento m\u00e9dico, presentaci\u00f3n, Vortioxetina 5, Vortioxetina 10, Vortioxetina 20"}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "c0bbc515441081827095209e6bf7bcbb7aaed8898c2b875e739b543096639dd9"}, "2": {"node_id": "31dd326c-ab65-4fbc-baa7-2bd9a7365b42", "node_type": null, "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "0f1aeb691038116e628d30c8c63085f7e8b0ae57d06ef7cea43dde510df0150d"}}, "hash": "f573c9345e08f7bcb835017ad58a31d27b888fd06f2ffd594cba49d979d81690", "text": "medicamento y la cantidad ingerida. Se recomienda llevar el envase y el prospecto del \nmedicamento al profesional sanitario.  \nLos s\u00edntomas en caso de sobredosi s son: mareo postural, n\u00e1useas, diarrea, molestias en el \nest\u00f3mago, picor en todo el cuerpo, somnolencia y rubefacci\u00f3n (enrojecimiento de la piel).  \nTras la ingesta de dosis varias veces superiores a la dosis prescrita, se han notificado episodios \nde convuls iones y S\u00edndrome Serotonin\u00e9rgico.  \nEn caso de sobredosis se deben tratar los s\u00edntomas cl\u00ednicos y someter a una monitorizaci\u00f3n \nadecuada. Se recomienda seguimiento m\u00e9dico en un entorno especializado.  \nPRESENTACI\u00d3N  \nVortioxetina 5: Cajas conteniendo 30 comprimid o recubiertos.  \nVortioxetina 10: Cajas conteniendo 30 comprimido recubiertos.  \nVortioxetina 20: Cajas conteniendo 30 comprimido recubiertos.", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}, "d4e0228c-464f-43ad-9ed6-d3418f4d4db1": {"__data__": {"id_": "d4e0228c-464f-43ad-9ed6-d3418f4d4db1", "embedding": null, "metadata": {"page_label": "7", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What is the recommended storage temperature for the medication Vortioxetine?\n2. Who should be contacted in case of any issues or concerns regarding the use of this medication?\n3. What is the contact information for the National Pharmacovigilance Center in the country where this medication is being used?\n\nHigher-level summary: This context provides information about the precautions and risks associated with the medication Vortioxetine, including the recommended storage temperature, contact information for reporting issues, and the fact that it is a controlled medication requiring a prescription.", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section also mentions the symptoms of an overdose of Vortioxetine and how it should be treated. Additionally, it provides information about the different presentations of Vortioxetine available and the number of tablets included in each package. The entities mentioned in this section include Vortioxetine, overdose symptoms, treatment, precautions, contraindications, and different presentations of the medication.", "section_summary": "The key topics of this section are the recommended storage temperature for the medication Vortioxetine, contact information for reporting issues or concerns about the medication, and the fact that it is a controlled medication requiring a prescription. The key entities mentioned are the National Pharmacovigilance Center and the pharmaceutical company Laboratorio Pharma.IA.", "excerpt_keywords": "producto medicinal, ni\u00f1os, temperatura ambiente, inconveniente, uso, centro nacional de farmacovigilancia, medicamento, t\u00f3xico, intoxicaci\u00f3n, centro de atenci\u00f3n, industria argentina, venta bajo receta profesional, medicamento controlado, titular en pa\u00eds, fabricante, laboratorio Pharma.IA, comercializado, distribuci\u00f3n exclusiva."}, "excluded_embed_metadata_keys": [], "excluded_llm_metadata_keys": ["questions_this_excerpt_can_answer"], "relationships": {"1": {"node_id": "61dd0b1f-4552-4592-b7c3-e182a8b4cac7", "node_type": null, "metadata": {"page_label": "7", "file_name": "Prospecto Vortioxetina Generico.pdf"}, "hash": "64e133b07aac3d6c7321f74ebcc575c95f3c9c1dd245229e13338b5e4050f6f8"}}, "hash": "508b32e9f12df252954801dd1ac6110b47a2d8ccf0266284faa1a47ba584425a", "text": "PRODUCTO MEDICINAL  \nMANT\u00c9NGASE FUERA DEL ALCANCE DE LOS NI\u00d1OS CONSERVAR A TEMPERATURA AMBIENTE \nINFERIOR A 30 \u00b0C \nEn caso de inconveniente con el uso de este producto comun\u00edquese con el Centro Nacional de \nFarmacovigilancia de su pa\u00eds.  \nNota:  Todo medicamento es potencialmente t\u00f3xico. En caso de intoxicaci\u00f3n llamar al  centro \nde atenci\u00f3n    \n                                             . \nIndustria Argenti na \nVenta bajo receta profesional MEDICAMENTO CONTROLADO Titular en Pa\u00eds y Fabricante: Laboratorio Pharma.IA ., \nComercializado y distribuci\u00f3n exclusiva laboratorio Pharma.IA", "start_char_idx": null, "end_char_idx": null, "text_template": "[Excerpt from document]\n{metadata_str}\nExcerpt:\n-----\n{content}\n-----\n", "metadata_template": "{key}: {value}", "metadata_seperator": "\n"}, "__type__": "1"}}, "docstore/ref_doc_info": {"522ac278-4954-44be-bf8c-ffca1be2f1bc": {"node_ids": ["38581f5e-de4f-43d9-9051-bec1e0402c29", "89cfbb89-9985-4563-8e0a-c30b7816aa39"], "metadata": {"page_label": "1", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the different dosages available for Vortioxetine and what is the active ingredient in each dosage?\n2. What is the purpose of Vortioxetine and what condition does it treat in adults?\n3. What precautions should be taken before starting to take Vortioxetine and when should this medication not be taken?", "section_summary": "This section provides information about the medication Vortioxetine, including its dosages, active ingredient, purpose, and precautions. The dosages available for Vortioxetine are 5mg, 10mg, and 20mg, with the active ingredient being Vortioxetine bromhydrate. Vortioxetine is used to treat major depression in adults. Before starting to take Vortioxetine, it is important to consider certain precautions and avoid taking the medication under certain circumstances.", "excerpt_keywords": "Vortioxetina, medicamento, prospecto, informaci\u00f3n, usuario, v\u00eda oral, comprimidos recubiertos, vigilancia adicional, tratamiento, recetado, personas, s\u00edntomas, duda, efecto adverso, m\u00e9dico, f\u00f3rmulas, bromhidrato, principio activo, antidepresivos, episodios, depresi\u00f3n mayor, adultos, tomar."}}, "ab6c173a-3c51-4192-9a95-f624b18c7e99": {"node_ids": ["ddf203a9-df29-440d-900f-c84c894e57a1", "92d383e2-5a2e-43f1-a706-3568521bc0ca", "4be18c04-0d07-4a88-bc0c-339e92743fbd", "b913cbf2-eb53-4ead-bf7e-950de6c142da"], "metadata": {"page_label": "2", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment?\n2. How should Vortioxetine be used with caution in patients with a history of seizures or unstable epilepsy?\n3. What precautions should be taken when using Vortioxetine in patients with a history of mania or hypomania?", "prev_section_summary": "This section provides important information about Vortioxetine, including precautions, contraindications, and risks associated with its use for treating major depression in adults. The section mentions that Vortioxetine is an antidepressant medication and should not be taken by individuals who are allergic to Vortioxetine or any of its components, or who are taking certain other medications such as non-selective monoamine oxidase inhibitors (MAOIs) or selective MAO-A inhibitors. It also advises caution when taking Vortioxetine in combination with medications that affect serotonin metabolism, serotoninergic active substances, antipsychotics, and other dopaminergic antagonists, as this may increase the risk of serotonin syndrome (SS) or neuroleptic malignant syndrome (SNM). The symptoms of SS are not mentioned in the provided excerpt.", "section_summary": "The key topics of this section are the potential side effects and symptoms that may indicate a serious reaction to Vortioxetine treatment, the caution needed when using Vortioxetine in patients with a history of seizures or unstable epilepsy, and the precautions to be taken when using Vortioxetine in patients with a history of mania or hypomania. The entities mentioned include changes in consciousness, autonomic instability, neuromuscular alterations, gastrointestinal symptoms, seizures, mania, and bleeding tendencies.", "excerpt_keywords": "cambios en el nivel de conciencia, agitaci\u00f3n, alucinaciones, estados de coma, inestabilidad aut\u00f3noma, taquicardia, presi\u00f3n arterial l\u00e1bil, hipertermia, alteraciones neuromusculares, hiperreflexia, descoordinaci\u00f3n, s\u00edntomas gastrointestinales, n\u00e1useas, v\u00f3mitos, diarrea, convulsiones, man\u00eda, tendencia a sangrar, hematomas f\u00e1cilmente."}}, "95710e24-7556-4ff3-b2b7-063b5ae2456c": {"node_ids": ["260e388b-8c94-4b17-b39e-5b122bbe644f", "ea7cff7b-7b84-49ce-8056-88d34c67e2ea", "02c8e2f2-b066-4566-a57e-185c910672a5", "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d"], "metadata": {"page_label": "3", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and side effects of using Vortioxetine during pregnancy?\n2. What symptoms may be observed in a newborn if the mother takes Vortioxetine during the last 3 months of pregnancy?\n3. What should a pregnant woman do if her baby exhibits any of the mentioned symptoms after birth?", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with using Vortioxetine for treating major depression in adults. It also mentions that Vortioxetine is not recommended for children and adolescents under 18 years old due to a lack of information in this age group. Additionally, it provides information about the use of Vortioxetine during pregnancy and breastfeeding.", "section_summary": "The key topics of this section are the potential risks and side effects of using Vortioxetine during pregnancy. It mentions that Vortioxetine should not be used during pregnancy unless absolutely necessary, and if the benefits outweigh the possible risks to the fetus. It also states that if Vortioxetine is taken during the last 3 months of pregnancy, certain effects may be observed in the newborn, such as breathing problems, blue skin, seizures, and difficulty feeding. The section advises pregnant women to contact their doctor immediately if their baby exhibits any of these symptoms after birth. The key entities mentioned in this section are Vortioxetine, pregnancy, newborn, and the potential symptoms in the baby.", "excerpt_keywords": "embarazo, lactancia, m\u00e9dico, vortioxetina, riesgo, feto, reci\u00e9n nacido, problemas respiratorios, piel azulada, convulsiones, dificultad de alimentaci\u00f3n, v\u00f3mitos, az\u00facar bajo en sangre, m\u00fasculos r\u00edgidos, reflejos intensos, temblor, irritabilidad, letargia, somnolencia, dificultades para dormir, hipertensi\u00f3n."}}, "7ed4e3fc-7410-4f6a-9799-9007ecb456bc": {"node_ids": ["1895eefa-e41f-40f0-88a5-dc52f54f61a2", "f1e2a382-4ccd-4a49-9eb6-36482b21e060", "9452c1be-1edb-456a-a85a-43cb62f83b4e", "9b2d3a5b-c571-40fe-9202-26acd06c2564"], "metadata": {"page_label": "4", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the potential risks and precautions associated with combining Vortioxetine with irreversible and selective MAO-B inhibitors?\n2. Can the concurrent use of Vortioxetine and medications with serotoninergic effects, such as tramadol or sumatriptan, lead to serotonin syndrome?\n3. How does the use of Vortioxetine in combination with medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs, affect the risk of seizures?", "prev_section_summary": "The key topics of this section are the contraindications and precautions for combining Vortioxetine with certain medications. The section specifically mentions the contraindication of combining Vortioxetine with a weak non-selective reversible MAOI like linezolid. It also discusses the precautions that should be taken when combining Vortioxetine with a reversible and selective MAO-A inhibitor like moclobemide. Additionally, the section mentions the recommended dosage and monitoring approach when combining Vortioxetine with an additional medication. The entities mentioned in this section include Vortioxetine, linezolid, moclobemide, and MAO-A.", "section_summary": "The section discusses the potential risks and precautions associated with combining Vortioxetine with certain medications. The key topics include the combination of Vortioxetine with irreversible and selective MAO-B inhibitors, medications with serotoninergic effects, such as tramadol or sumatriptan, and medications that lower the seizure threshold, such as tricyclic antidepressants or SSRIs. The section also mentions the contraindication of combining Vortioxetine with St. John's Wort. The key entities mentioned are Vortioxetine, irreversible and selective MAO-B inhibitors, tramadol, sumatriptan, St. John's Wort, tricyclic antidepressants, and SSRIs.", "excerpt_keywords": "depresi\u00f3n, contraindicaci\u00f3n, combinaci\u00f3n, dosis m\u00ednima, monitorizaci\u00f3n cl\u00ednica, SS, inhibidores de la MAO-B, selegilina, rasagilina, enfermedad de Parkinson, precauci\u00f3n, medicamentos serotonin\u00e9rgicos, tramadol, sumatript\u00e1n, -tript\u00e1n, migra\u00f1a, Hierba de San Juan, Hypericum perforatum, reacciones adversas, umbral convulsivo, antidepresivos tric\u00edclicos, ISRS, IRSN."}}, "d69ca6ed-f926-4841-a592-7fc400f9002f": {"node_ids": ["f0c7c151-f604-4ab6-b62d-fb97e74e7ee4", "c44684d7-a3f9-4d0e-a0bf-539a90eb853b", "04bfad7a-0c57-4de6-bd62-1ddf54451460"], "metadata": {"page_label": "5", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What are the possible side effects of taking Vortioxetine and when do they typically occur?\n2. Can Vortioxetine be taken with alcohol?\n3. What are the precautions and contraindications for using Vortioxetine to treat major depression in adults?", "prev_section_summary": "The section discusses the precautions and risks associated with combining Vortioxetine with the oral contraceptive pill containing ethinyl estradiol and levonorgestrel. It also mentions the cautious use of Vortioxetine when taken together with lithium and tryptophan, medications used to treat depression and mental disorders. Additionally, there is information regarding the administration of Vortioxetine with food and beverages.", "section_summary": "The section discusses the precautions, contraindications, and possible side effects of taking Vortioxetine, a medication used to treat major depression in adults. It mentions that the tablets can be taken with or without food, but it is not recommended to combine the medication with alcohol. The possible side effects are generally mild or moderate and occur within the first two weeks of treatment. Some of the common side effects include nausea, diarrhea, constipation, vomiting, dizziness, itching, abnormal dreams, and flushing of the skin. It also mentions that low levels of sodium in the blood may occur, which can cause symptoms such as dizziness and weakness.", "excerpt_keywords": "Vortioxetina, comprimidos, alimentos, combinaci\u00f3n, alcohol, efectos adversos, n\u00e1useas, diarrea, estre\u00f1imiento, v\u00f3mitos, mareo, prurito, picor, sue\u00f1os anormales, rubefacci\u00f3n, enrojecimiento de la piel, sudores nocturnos, niveles bajos de sodio en sangre, sensaci\u00f3n de mareo, debilidad."}}, "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3": {"node_ids": ["3dadae44-9de5-46c3-8b83-46f87c49d1c8", "31dd326c-ab65-4fbc-baa7-2bd9a7365b42", "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e"], "metadata": {"page_label": "6", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What precautions should be taken when treating patients with renal or hepatic insufficiency with Vortioxetine?\n2. How should the dosage of Vortioxetine be adjusted when combined with potent inhibitors or inducers of the cytochrome P450 enzyme?\n3. How long should Vortioxetine be taken and for how long after feeling better should the treatment continue?", "prev_section_summary": "The key topics of this section are the recommended dosages of Vortioxetine for adults under 65 years old and for elderly patients, precautions and contraindications for taking Vortioxetine in patients over 50 years old, and potential side effects of Vortioxetine. The key entities mentioned are Vortioxetine, adults under 65 years old, elderly patients, and patients over 50 years old.", "section_summary": "The key topics of this section are precautions and risks associated with the use of Vortioxetine in patients with renal or hepatic insufficiency, dosage adjustment when combined with potent inhibitors or inducers of the cytochrome P450 enzyme, and the recommended duration of treatment. The entities mentioned include Vortioxetine, renal or hepatic insufficiency, inhibitors of the cytochrome P450 enzyme, and inducers of the cytochrome P450 enzyme.", "excerpt_keywords": "ajuste de dosis, funci\u00f3n renal, funci\u00f3n hep\u00e1tica, insuficiencia renal, insuficiencia hep\u00e1tica, precauci\u00f3n, inhibidores del citocromo P450, dosis m\u00e1s baja, inhibidor potente, inductores del citocromo P450, ajuste de dosis, duraci\u00f3n del tratamiento, m\u00e9dico, mejor\u00eda, olvido, Vortioxetina."}}, "61dd0b1f-4552-4592-b7c3-e182a8b4cac7": {"node_ids": ["d4e0228c-464f-43ad-9ed6-d3418f4d4db1"], "metadata": {"page_label": "7", "file_name": "Prospecto Vortioxetina Generico.pdf", "document_title": "Important Information about Vortioxetine: Precautions, Contraindications, and Risks for Treating Major Depression in Adults", "questions_this_excerpt_can_answer": "1. What is the recommended storage temperature for the medication Vortioxetine?\n2. Who should be contacted in case of any issues or concerns regarding the use of this medication?\n3. What is the contact information for the National Pharmacovigilance Center in the country where this medication is being used?\n\nHigher-level summary: This context provides information about the precautions and risks associated with the medication Vortioxetine, including the recommended storage temperature, contact information for reporting issues, and the fact that it is a controlled medication requiring a prescription.", "prev_section_summary": "The key topics of this section are the precautions, contraindications, and risks associated with taking Vortioxetine for treating major depression in adults. The section also mentions the symptoms of an overdose of Vortioxetine and how it should be treated. Additionally, it provides information about the different presentations of Vortioxetine available and the number of tablets included in each package. The entities mentioned in this section include Vortioxetine, overdose symptoms, treatment, precautions, contraindications, and different presentations of the medication.", "section_summary": "The key topics of this section are the recommended storage temperature for the medication Vortioxetine, contact information for reporting issues or concerns about the medication, and the fact that it is a controlled medication requiring a prescription. The key entities mentioned are the National Pharmacovigilance Center and the pharmaceutical company Laboratorio Pharma.IA.", "excerpt_keywords": "producto medicinal, ni\u00f1os, temperatura ambiente, inconveniente, uso, centro nacional de farmacovigilancia, medicamento, t\u00f3xico, intoxicaci\u00f3n, centro de atenci\u00f3n, industria argentina, venta bajo receta profesional, medicamento controlado, titular en pa\u00eds, fabricante, laboratorio Pharma.IA, comercializado, distribuci\u00f3n exclusiva."}}}, "docstore/metadata": {"38581f5e-de4f-43d9-9051-bec1e0402c29": {"doc_hash": "c496fade0ab667bf370e31b8ad9afa38de9a0950936e88bc42b15a8a6ff76a5d", "ref_doc_id": "522ac278-4954-44be-bf8c-ffca1be2f1bc"}, "89cfbb89-9985-4563-8e0a-c30b7816aa39": {"doc_hash": "eadf913a5dd2a8113d26a409e651e8c7cebe9cf242488f3e87399389dcd5aa5d", "ref_doc_id": "522ac278-4954-44be-bf8c-ffca1be2f1bc"}, "ddf203a9-df29-440d-900f-c84c894e57a1": {"doc_hash": "e674c968deacc17d5cdc75f5fb553efb7b983f56c0ed3be3a1eece597b6b6e05", "ref_doc_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99"}, "92d383e2-5a2e-43f1-a706-3568521bc0ca": {"doc_hash": "ab44c8156fce3b4638e0fa1e3a567aa3ee3aed9a1d8ddf95560c59ba69092e23", "ref_doc_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99"}, "4be18c04-0d07-4a88-bc0c-339e92743fbd": {"doc_hash": "de9a4071a5477e335fc1bed3228827b59230f9d012bffaaaec577e39e30498e3", "ref_doc_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99"}, "b913cbf2-eb53-4ead-bf7e-950de6c142da": {"doc_hash": "e2e94726c2436696708d456be65a65c3e7b0be84a02babcab96c2f2c5a8a70d3", "ref_doc_id": "ab6c173a-3c51-4192-9a95-f624b18c7e99"}, "260e388b-8c94-4b17-b39e-5b122bbe644f": {"doc_hash": "0b3af772ddf2bddae91c03cfaf8d8e83a7bb158ac426ae11832faabb14f11d50", "ref_doc_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c"}, "ea7cff7b-7b84-49ce-8056-88d34c67e2ea": {"doc_hash": "cee9353471cf98ec1b1e59fcb4d9a29e77a8c7116922aa51e4eeba6f40a6b633", "ref_doc_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c"}, "02c8e2f2-b066-4566-a57e-185c910672a5": {"doc_hash": "4cf763c0ba356a8ecfb3751bcf13dac137fd3afdf12510ebd96fe1041b417f1c", "ref_doc_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c"}, "a4b6b1f2-9e51-45b8-9812-d85dfe066e8d": {"doc_hash": "3f8fab90b70fad820d86b8270f49d158755cc2bbde327840bbe160e1268e3853", "ref_doc_id": "95710e24-7556-4ff3-b2b7-063b5ae2456c"}, "1895eefa-e41f-40f0-88a5-dc52f54f61a2": {"doc_hash": "6493cd35493399b37d1ea7ec36769be534a2c55fb5c8b27e23edbcf08e9cabdd", "ref_doc_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc"}, "f1e2a382-4ccd-4a49-9eb6-36482b21e060": {"doc_hash": "4c01ae808cf9ba9098431907d512ce70f0cee296fc5c64cb5265cb74c3d4ceeb", "ref_doc_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc"}, "9452c1be-1edb-456a-a85a-43cb62f83b4e": {"doc_hash": "4fc35df3be392d92a23bce5c184a529d65b575c1ef9bf08b19503fb0e2daad20", "ref_doc_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc"}, "9b2d3a5b-c571-40fe-9202-26acd06c2564": {"doc_hash": "668b4645e65ea2ed49e0ff9332f7fa4aea0f2815de6a5585607d5a0d6ffcebba", "ref_doc_id": "7ed4e3fc-7410-4f6a-9799-9007ecb456bc"}, "f0c7c151-f604-4ab6-b62d-fb97e74e7ee4": {"doc_hash": "ed84bb54a758054a23657e4e2676944504537e1d8962a018494531ec8e6f1f1c", "ref_doc_id": "d69ca6ed-f926-4841-a592-7fc400f9002f"}, "c44684d7-a3f9-4d0e-a0bf-539a90eb853b": {"doc_hash": "e45eeff75717c2d7b5cf0b6036dfc0b00ad01c1967a360a5ff041e712791f643", "ref_doc_id": "d69ca6ed-f926-4841-a592-7fc400f9002f"}, "04bfad7a-0c57-4de6-bd62-1ddf54451460": {"doc_hash": "d998cff15e5aece521f7afc83b0441369edb495869b95d815b9dde7d55f7c2ab", "ref_doc_id": "d69ca6ed-f926-4841-a592-7fc400f9002f"}, "3dadae44-9de5-46c3-8b83-46f87c49d1c8": {"doc_hash": "63819555553cbe1d1f6ec4b4b29545b7c8f46dd5a49943d47b1bfc27ee6a6e70", "ref_doc_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3"}, "31dd326c-ab65-4fbc-baa7-2bd9a7365b42": {"doc_hash": "0f1aeb691038116e628d30c8c63085f7e8b0ae57d06ef7cea43dde510df0150d", "ref_doc_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3"}, "36ba3fc6-801a-4e2d-b8d6-52906e11ff7e": {"doc_hash": "f573c9345e08f7bcb835017ad58a31d27b888fd06f2ffd594cba49d979d81690", "ref_doc_id": "8183699c-7bb6-4fcb-bfa1-d547c0bd7cb3"}, "d4e0228c-464f-43ad-9ed6-d3418f4d4db1": {"doc_hash": "508b32e9f12df252954801dd1ac6110b47a2d8ccf0266284faa1a47ba584425a", "ref_doc_id": "61dd0b1f-4552-4592-b7c3-e182a8b4cac7"}}}
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