example_patient_input.json

{
  "description": "Example HBV patient data for assessment API",
  "examples": [
    {
      "name": "Eligible Patient - Moderate Fibrosis",
      "data": {
        "sex": "Male",
        "age": 45,
        "pregnancy_status": "Not pregnant",
        "hbsag_status": "Positive",
        "duration_hbsag_months": 12,
        "hbv_dna_level": 50000,
        "hbeag_status": "Positive",
        "alt_level": 60,
        "fibrosis_stage": "F2-F3",
        "necroinflammatory_activity": "A2",
        "extrahepatic_manifestations": false,
        "immunosuppression_status": "None",
        "coinfections": [],
        "family_history_cirrhosis_hcc": false,
        "other_comorbidities": []
      },
      "expected_result": "Eligible - meets SASLT 2021 criteria (HBV DNA > 2,000, ALT > ULN, moderate fibrosis)"
    },
    {
      "name": "Eligible Patient - Cirrhosis",
      "data": {
        "sex": "Male",
        "age": 55,
        "pregnancy_status": "Not pregnant",
        "hbsag_status": "Positive",
        "duration_hbsag_months": 120,
        "hbv_dna_level": 500,
        "hbeag_status": "Negative",
        "alt_level": 30,
        "fibrosis_stage": "F4",
        "necroinflammatory_activity": "A1",
        "extrahepatic_manifestations": false,
        "immunosuppression_status": "None",
        "coinfections": [],
        "family_history_cirrhosis_hcc": true,
        "other_comorbidities": ["Diabetes"]
      },
      "expected_result": "Eligible - cirrhosis (F4) with detectable HBV DNA"
    },
    {
      "name": "Not Eligible Patient - Low HBV DNA",
      "data": {
        "sex": "Female",
        "age": 35,
        "pregnancy_status": "Not pregnant",
        "hbsag_status": "Positive",
        "duration_hbsag_months": 8,
        "hbv_dna_level": 1500,
        "hbeag_status": "Negative",
        "alt_level": 20,
        "fibrosis_stage": "F0-F1",
        "necroinflammatory_activity": "A0",
        "extrahepatic_manifestations": false,
        "immunosuppression_status": "None",
        "coinfections": [],
        "family_history_cirrhosis_hcc": false,
        "other_comorbidities": []
      },
      "expected_result": "Not Eligible - does not meet SASLT 2021 criteria"
    },
    {
      "name": "Pregnant Patient - High HBV DNA",
      "data": {
        "sex": "Female",
        "age": 28,
        "pregnancy_status": "Pregnant",
        "hbsag_status": "Positive",
        "duration_hbsag_months": 24,
        "hbv_dna_level": 150000,
        "hbeag_status": "Positive",
        "alt_level": 40,
        "fibrosis_stage": "F0-F1",
        "necroinflammatory_activity": "A1",
        "extrahepatic_manifestations": false,
        "immunosuppression_status": "None",
        "coinfections": [],
        "family_history_cirrhosis_hcc": false,
        "other_comorbidities": []
      },
      "expected_result": "Eligible - HBV DNA > 2,000, ALT > ULN. Note: Pregnant with HBV DNA > 100,000 requires prophylaxis"
    },
    {
      "name": "Patient with Extrahepatic Manifestations",
      "data": {
        "sex": "Male",
        "age": 42,
        "pregnancy_status": "Not pregnant",
        "hbsag_status": "Positive",
        "duration_hbsag_months": 36,
        "hbv_dna_level": 5000,
        "hbeag_status": "Negative",
        "alt_level": 28,
        "fibrosis_stage": "F0-F1",
        "necroinflammatory_activity": "A0",
        "extrahepatic_manifestations": true,
        "immunosuppression_status": "None",
        "coinfections": [],
        "family_history_cirrhosis_hcc": false,
        "other_comorbidities": ["Polyarteritis nodosa"]
      },
      "expected_result": "Eligible - extrahepatic manifestations (Grade D)"
    },
    {
      "name": "Patient with HIV Coinfection",
      "data": {
        "sex": "Male",
        "age": 38,
        "pregnancy_status": "Not pregnant",
        "hbsag_status": "Positive",
        "duration_hbsag_months": 60,
        "hbv_dna_level": 25000,
        "hbeag_status": "Positive",
        "alt_level": 80,
        "fibrosis_stage": "F2-F3",
        "necroinflammatory_activity": "A2",
        "extrahepatic_manifestations": false,
        "immunosuppression_status": "None",
        "coinfections": ["HIV"],
        "family_history_cirrhosis_hcc": false,
        "other_comorbidities": []
      },
      "expected_result": "Eligible - meets multiple criteria. Note: HIV coinfection requires specialized management"
    },
    {
      "name": "HBeAg-positive Chronic Infection (Age > 30)",
      "data": {
        "sex": "Female",
        "age": 35,
        "pregnancy_status": "Not pregnant",
        "hbsag_status": "Positive",
        "duration_hbsag_months": 180,
        "hbv_dna_level": 1000000,
        "hbeag_status": "Positive",
        "alt_level": 22,
        "fibrosis_stage": "F0-F1",
        "necroinflammatory_activity": "A0",
        "extrahepatic_manifestations": false,
        "immunosuppression_status": "None",
        "coinfections": [],
        "family_history_cirrhosis_hcc": false,
        "other_comorbidities": []
      },
      "expected_result": "Eligible - HBeAg-positive chronic infection, age > 30 (Grade D)"
    }
  ],
  "field_descriptions": {
    "sex": "Male or Female",
    "age": "Patient age in years (0-120)",
    "pregnancy_status": "Not pregnant or Pregnant",
    "hbsag_status": "Positive or Negative",
    "duration_hbsag_months": "Duration of HBsAg positivity in months (≥ 6 months required)",
    "hbv_dna_level": "HBV DNA level in IU/mL",
    "hbeag_status": "Positive or Negative",
    "alt_level": "ALT level in U/L (ULN: Men ≤ 35, Women ≤ 25)",
    "fibrosis_stage": "F0-F1 (minimal), F2-F3 (moderate), or F4 (cirrhosis)",
    "necroinflammatory_activity": "A0 (none), A1 (mild), A2 (moderate), or A3 (severe)",
    "extrahepatic_manifestations": "true or false",
    "immunosuppression_status": "None, Chemotherapy, or Other",
    "coinfections": "Array of: HIV, HCV, HDV",
    "family_history_cirrhosis_hcc": "true or false (first-degree relative)",
    "other_comorbidities": "Array of comorbidity names"
  }
}