diff --git "a/tagged_grants.jsonl" "b/tagged_grants.jsonl" --- "a/tagged_grants.jsonl" +++ "b/tagged_grants.jsonl" @@ -1,10 +1,100 @@ -{"id":"360G-Wellcome-221604_Z_20_Z","title":"Immunometabolic cross-talk in the inflamed diabetic heart","Region":"Greater London","currency":"GBP","awardDate":"2020-11-11T00:00:00+00:00","Sponsor(s)":"Prof Mark Caulfield","Internal ID":"221604/Z/20/Z","description":"Diabetic cardiomyopathy (dbCM) is a complication of type II diabetes (T2D), characterised by systemic inflammation, impaired cardiac function and disrupted metabolism. However, the impact of systemic inflammation on the development of the myocardial inflammation and cardiac metabolic derangement that lead to dbCM remain unknown. This study will address how chronic adaptive inflammation driven by systemic metabolic stress in T2D causes cardiac dysfunction. Specifically, I hypothesise that it is caused by inflammation due to T-cell infiltration and not by direct metabolic perturbations that can lead to impaired energetics (reduced PCr/ATP ratio). Specifically, the aim is to use integrated experimental approach combining metabolic analysis with T-cell phenotypic profiling in murine and human T2D to address three research challenges:\n\nA. Does infiltration of cardiotropic T-cells impair cardiac substrate plasticity and energetics in dbCM?\n\nB. Do myocardial succinate efflux and signalling via SUCNR1 promote cardiac Teff and/or Treg activation by modifying T-cell metabolism and do they enhance pro-inflammatory T-cell differentiation?\n\nC. Does stimulation of GCK-mediated glycolysis increase regulatory T-cell migration to the heart causing a switch in the nature of immune response from pro-inflammatory to immunosuppressive? Does the resultant reduction in myocardial exposure to pro-inflammatory cytokines improve cardiac function and mitochondrial performance? \n","plannedDates":[{"endDate":"2025-01-10T00:00:00+00:00","startDate":"2021-01-11T00:00:00+00:00","startDateDateOnly":"2021-01-11","endDateDateOnly":"2025-01-10"}],"amountAwarded":630613,"Financial Year":"2020/21","Lead Applicant":"Dr Dunja Aksentijevic","grantProgramme":[{"title":"Career Re-Entry Fellowship","title_keyword":"Career Re-Entry Fellowship"}],"Applicant Surname":"Aksentijevic","Partnership Value":630613,"Approval Committee":"Basic Science Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Queen-Mary-University-of-London","name":"Queen Mary University of London","addressCountry":"United Kingdom","id_and_name":"[\"Queen Mary University of London\", \"360G-Wellcome-ORG:Queen-Mary-University-of-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Queen-Mary-University-of-London","name":"Queen Mary University of London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Immunometabolic cross-talk in the inflamed diabetic heart Diabetic cardiomyopathy (dbCM) is a complication of type II diabetes (T2D), characterised by systemic inflammation, impaired cardiac function and disrupted metabolism. However, the impact of systemic inflammation on the development of the myocardial inflammation and cardiac metabolic derangement that lead to dbCM remain unknown. This study will address how chronic adaptive inflammation driven by systemic metabolic stress in T2D causes cardiac dysfunction. Specifically, I hypothesise that it is caused by inflammation due to T-cell infiltration and not by direct metabolic perturbations that can lead to impaired energetics (reduced PCr/ATP ratio). Specifically, the aim is to use integrated experimental approach combining metabolic analysis with T-cell phenotypic profiling in murine and human T2D to address three research challenges:\n\nA. Does infiltration of cardiotropic T-cells impair cardiac substrate plasticity and energetics in dbCM?\n\nB. Do myocardial succinate efflux and signalling via SUCNR1 promote cardiac Teff and/or Treg activation by modifying T-cell metabolism and do they enhance pro-inflammatory T-cell differentiation?\n\nC. Does stimulation of GCK-mediated glycolysis increase regulatory T-cell migration to the heart causing a switch in the nature of immune response from pro-inflammatory to immunosuppressive? Does the resultant reduction in myocardial exposure to pro-inflammatory cytokines improve cardiac function and mitochondrial performance? \n","awardDateDateOnly":"2020-11-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Adaptive Immunity","Animals","Diabetes Mellitus, Type 2","Energy Metabolism","Glycolysis","Humans","Inflammation","Mice","T-Lymphocytes","T-Lymphocytes, Regulatory"]} -{"id":"360G-Wellcome-221598_Z_20_Z","title":"Oral Ketamine Capsules - A new potential treatment for Depression. A pharmacokinetic and pharmacodynamic assessment of Ketamine and Metabolites in a dose-escalating, placebo-controlled clinical trial in healthy subjects.","Region":"Scotland","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221598/Z/20/Z","description":"Neurocentrx has developed oral capsule formulations of Ketamine, aiming to be new treatments for Depression. Ketamine is a synthetic drug created in the 1960\u2019s. It is on the \"essential medicine\" list of the World Health Organisation (WHO), approved and licensed by health regulators worldwide as an injectable anaesthetic. More recently, and at sub-anaesthetic doses, clinical trials have shown that some patients with depression have a rapid response to injectable ketamine (hours or days). Most other anti-depressant medicines take many weeks to work. No oral ketamine products are currently available as a licensed medicine worldwide. Our project will assess oral capsules in healthy people in a clinical trial. We will assess absorption and excretion with increasing doses of drug and measure any side-effects. These data will be essential to accurately plan trials in depression patients where we will then look for benefits. Oral capsules could be used at home, and are hoped to be a cheaper treatment option, with fewer side-effects for patients. The summary above may be amended from time to time by mutual agreement of the Parties. For this clause agreement by email will be sufficient to render a valid amendment to the summary).","plannedDates":[{"endDate":"2022-04-10T00:00:00+00:00","startDate":"2020-11-09T00:00:00+00:00","startDateDateOnly":"2020-11-09","endDateDateOnly":"2022-04-10"}],"amountAwarded":498326,"Financial Year":"2019/20","Lead Applicant":"Dr Carmel Reilly","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Reilly","Partnership Value":498326,"Approval Committee":"Innovator Awards Advisory Group","Other Applicant(s)":"Dr Mario Juruena","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Neurocentrx-Pharma-Ltd","name":"Neurocentrx Pharma Ltd","addressCountry":"United Kingdom","id_and_name":"[\"Neurocentrx Pharma Ltd\", \"360G-Wellcome-ORG:Neurocentrx-Pharma-Ltd\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Neurocentrx-Pharma-Ltd","name":"Neurocentrx Pharma Ltd"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Oral Ketamine Capsules - A new potential treatment for Depression. A pharmacokinetic and pharmacodynamic assessment of Ketamine and Metabolites in a dose-escalating, placebo-controlled clinical trial in healthy subjects. Neurocentrx has developed oral capsule formulations of Ketamine, aiming to be new treatments for Depression. Ketamine is a synthetic drug created in the 1960\u2019s. It is on the \"essential medicine\" list of the World Health Organisation (WHO), approved and licensed by health regulators worldwide as an injectable anaesthetic. More recently, and at sub-anaesthetic doses, clinical trials have shown that some patients with depression have a rapid response to injectable ketamine (hours or days). Most other anti-depressant medicines take many weeks to work. No oral ketamine products are currently available as a licensed medicine worldwide. Our project will assess oral capsules in healthy people in a clinical trial. We will assess absorption and excretion with increasing doses of drug and measure any side-effects. These data will be essential to accurately plan trials in depression patients where we will then look for benefits. Oral capsules could be used at home, and are hoped to be a cheaper treatment option, with fewer side-effects for patients. The summary above may be amended from time to time by mutual agreement of the Parties. For this clause agreement by email will be sufficient to render a valid amendment to the summary).","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Administration, Oral","Adult","Capsules","Dose-Response Relationship, Drug","Double-Blind Method","Humans","Ketamine","Research Design"]} -{"id":"360G-Wellcome-221597_Z_20_Z","title":"The evaluation of novel GBS conjugates prepared from GBS capsular polysaccharides and GBS conserved surface proteins\u2019","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221597/Z/20/Z","description":"Group B Streptococcus (GBS) bacterial infection is a major health concern and a leading cause of sepsis and meningitis in infants, particularly in Africa. A promising prevention for GBS infection in newborns is maternal immunization with a GBS vaccine. Currently no vaccine for GBS is available. Several conjugate GBS vaccines using GBS surface-expressed polysaccharides linked to carrier proteins are under development. We are proposing a novel vaccine design using GBS polysaccharides conjugated to GBS conserved surface proteins which induce immune responses in infected individuals, making them potential candidates as carrier proteins for novel GBS vaccines. It combines two virulence factors of GBS with the potential to provide not only enhanced overall protection compared to traditional conjugate vaccines but also to potentially provide protection against those serotypes not included in the vaccine. It could lead to the development of an affordable and cost-effective vaccine that protects against all GBS serotypes.","plannedDates":[{"endDate":"2022-10-30T00:00:00+00:00","startDate":"2021-05-03T00:00:00+00:00","startDateDateOnly":"2021-05-03","endDateDateOnly":"2022-10-30"}],"amountAwarded":398043,"Financial Year":"2019/20","Lead Applicant":"Dr Seanette Wilson","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Wilson","Partnership Value":398043,"Approval Committee":"Innovator Awards Advisory Group","Other Applicant(s)":"Dr Gaurav Kwatra","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:The-Biovac-Institute","name":"The Biovac Institute","addressCountry":"South Africa","id_and_name":"[\"The Biovac Institute\", \"360G-Wellcome-ORG:The-Biovac-Institute\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:The-Biovac-Institute","name":"The Biovac Institute"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"The evaluation of novel GBS conjugates prepared from GBS capsular polysaccharides and GBS conserved surface proteins\u2019 Group B Streptococcus (GBS) bacterial infection is a major health concern and a leading cause of sepsis and meningitis in infants, particularly in Africa. A promising prevention for GBS infection in newborns is maternal immunization with a GBS vaccine. Currently no vaccine for GBS is available. Several conjugate GBS vaccines using GBS surface-expressed polysaccharides linked to carrier proteins are under development. We are proposing a novel vaccine design using GBS polysaccharides conjugated to GBS conserved surface proteins which induce immune responses in infected individuals, making them potential candidates as carrier proteins for novel GBS vaccines. It combines two virulence factors of GBS with the potential to provide not only enhanced overall protection compared to traditional conjugate vaccines but also to potentially provide protection against those serotypes not included in the vaccine. It could lead to the development of an affordable and cost-effective vaccine that protects against all GBS serotypes.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Antibodies, Bacterial","Bacterial Capsules","Humans","Serogroup","Streptococcal Infections","Streptococcal Vaccines","Streptococcus agalactiae","Vaccines, Conjugate"]} -{"id":"360G-Wellcome-221595_Z_20_Z","title":"Preclinical Toxicology Testing and IND application for a Novel Cholera Conjugate Vaccine","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221595/Z/20/Z","description":"Cholera is a disease of inequity that continues to disproportionately affect the world\u2019s poorest and\nmost vulnerable people. An oral cholera vaccine (OCV) is available and in use around the world,\nbut it has lower efficacy in young children than in adults and a relatively short duration of protection\nnecessitating re-vaccination every few years. We are developing a new conjugate vaccine that\noffers the promise of improved efficacy in all age groups, including those less than 5 years, and an\nextended duration of protection, thus reducing the requirements for repetitive vaccination to sustain\npopulation immunity. It can be implemented in place of OCV or as a complementary tool to prevent\nor limit outbreaks in high risk settings, and build enduring population immunity that will costeffectively\ncontrol cholera over the decades required to build definitive public health capacities in at\nrisk countries.","plannedDates":[{"endDate":"2021-10-31T00:00:00+00:00","startDate":"2020-11-01T00:00:00+00:00","startDateDateOnly":"2020-11-01","endDateDateOnly":"2021-10-31"}],"amountAwarded":456865,"Financial Year":"2019/20","Lead Applicant":"Dr Julia Lynch","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Lynch","Partnership Value":456865,"Approval Committee":"Innovator Awards Advisory Group","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:International-Vaccine-Institute","name":"International Vaccine Institute","addressCountry":"Korea, South","id_and_name":"[\"International Vaccine Institute\", \"360G-Wellcome-ORG:International-Vaccine-Institute\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:International-Vaccine-Institute","name":"International Vaccine Institute"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Preclinical Toxicology Testing and IND application for a Novel Cholera Conjugate Vaccine Cholera is a disease of inequity that continues to disproportionately affect the world\u2019s poorest and\nmost vulnerable people. An oral cholera vaccine (OCV) is available and in use around the world,\nbut it has lower efficacy in young children than in adults and a relatively short duration of protection\nnecessitating re-vaccination every few years. We are developing a new conjugate vaccine that\noffers the promise of improved efficacy in all age groups, including those less than 5 years, and an\nextended duration of protection, thus reducing the requirements for repetitive vaccination to sustain\npopulation immunity. It can be implemented in place of OCV or as a complementary tool to prevent\nor limit outbreaks in high risk settings, and build enduring population immunity that will costeffectively\ncontrol cholera over the decades required to build definitive public health capacities in at\nrisk countries.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Administration, Oral","Adolescent","Adult","Child","Child, Preschool","Cholera","Cholera Vaccines","Humans"]} -{"id":"360G-Wellcome-221590_Z_20_Z","title":"AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment ","Region":"North West","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221590/Z/20/Z","description":"Conventional evaluation of new medicines is not fast enough for a pandemic. Our aim is to accelerate this process, rapidly identifying which drugs are safe and potentially effective treatments for COVID-19. AGILE is an innovative, multi-arm, multi-dose, multi-stage Phase I/IIa Bayesian adaptive platform protocol to evaluate experimental COVID-19 therapies, and to funnel plausible candidates into large Phase IIb/III trials such as RECOVERY and SOLIDARITY. We will efficiently eliminate candidates with little or no prospect of clinical success.\n\nAGILE will recruit COVID-19 patients into very early phase clinical studies, including first-in-human. The innovative design allows us to move seamlessly from first-in-human use to finding the optimal dose for COVID-19 patients. The trial is pragmatic (requiring only small numbers of patients), adaptive (so that the right drug is tested in the right group of COVID-19 patients, either in the community or in hospital) and statistically efficient (so that several drugs can be tested in parallel, making best use of a small number of patients). Our primary focus is population-scalable antiviral drugs for early treatment of COVID-19, for which we will recruit primarily in the community. AGILE has full regulatory and ethics approvals in the UK.\n \n","plannedDates":[{"endDate":"2023-01-31T00:00:00+00:00","startDate":"2021-02-01T00:00:00+00:00","startDateDateOnly":"2021-02-01","endDateDateOnly":"2023-01-31"}],"amountAwarded":3069077,"Financial Year":"2019/20","Lead Applicant":"Prof Saye Khoo","grantProgramme":[{"title":"Therapeutics Accelerator ","title_keyword":"Therapeutics Accelerator "}],"Applicant Surname":"Khoo","Partnership Value":3069077,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Dr Richard Fitzgerald, Prof Gareth Griffiths, Prof Sir Munir Pirmohamed, Dr Mohammed Lamorde, Prof Catherine Orrell, Prof David Lalloo, Dr Shevin Jacob, Dr Thomas Fletcher, Prof Andrew Owen, Prof Francois Venter, Prof Thomas Jaki, Dr Bella Starling, Prof William Greenhalf, Sir Michael Jacobs","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Liverpool","name":"University of Liverpool","addressCountry":"United Kingdom","id_and_name":"[\"University of Liverpool\", \"360G-Wellcome-ORG:University-of-Liverpool\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Liverpool","name":"University of Liverpool"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment Conventional evaluation of new medicines is not fast enough for a pandemic. Our aim is to accelerate this process, rapidly identifying which drugs are safe and potentially effective treatments for COVID-19. AGILE is an innovative, multi-arm, multi-dose, multi-stage Phase I/IIa Bayesian adaptive platform protocol to evaluate experimental COVID-19 therapies, and to funnel plausible candidates into large Phase IIb/III trials such as RECOVERY and SOLIDARITY. We will efficiently eliminate candidates with little or no prospect of clinical success.\n\nAGILE will recruit COVID-19 patients into very early phase clinical studies, including first-in-human. The innovative design allows us to move seamlessly from first-in-human use to finding the optimal dose for COVID-19 patients. The trial is pragmatic (requiring only small numbers of patients), adaptive (so that the right drug is tested in the right group of COVID-19 patients, either in the community or in hospital) and statistically efficient (so that several drugs can be tested in parallel, making best use of a small number of patients). Our primary focus is population-scalable antiviral drugs for early treatment of COVID-19, for which we will recruit primarily in the community. AGILE has full regulatory and ethics approvals in the UK.\n \n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Antiviral Agents","Bayes Theorem","Clinical Trials, Phase I as Topic","Humans","Research Design"]} -{"id":"360G-Wellcome-221589_Z_20_Z","title":"Development of a Universal Group A Streptococcus Glycoconjugate Vaccine","Region":"Scotland","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221589/Z/20/Z","description":"The pathogenic bacterium Group A Streptococcus (GAS) causes a range of infections, ranging from mild tonsillitis to invasive necrotising fasciitis, sepsis and toxic shock syndrome. GAS also induces severe long-lasting autoimmune disease, including rheumatic heart disease. Annually, GAS infections kill > 500,000 people worldwide. While antibiotics are considered a reliable first line of defence against GAS infections, globally emerging antimicrobial resistance is an enormous threat. The WHO has included GAS in its vaccine priority list to finally reduce the high mortality and morbidity. We will use our developed novel modular system to produce the first dual-acting and lowcost GAS vaccine candidates targeting all > 150 GAS strains. Our approach provides the first robust and affordable solution to target and prevent GAS infections, urgently required for the global population and in particular the people in low-income countries.","plannedDates":[{"endDate":"2023-09-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00","startDateDateOnly":"2021-10-01","endDateDateOnly":"2023-09-30"}],"amountAwarded":402298,"Financial Year":"2019/20","Lead Applicant":"Dr Helge Dorfmueller","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Dorfmueller","Partnership Value":402298,"Approval Committee":"Innovator Awards Advisory Group","Other Applicant(s)":"Prof Brendan Wren","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Dundee","name":"University of Dundee","addressCountry":"United Kingdom","id_and_name":"[\"University of Dundee\", \"360G-Wellcome-ORG:University-of-Dundee\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Dundee","name":"University of Dundee"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Development of a Universal Group A Streptococcus Glycoconjugate Vaccine The pathogenic bacterium Group A Streptococcus (GAS) causes a range of infections, ranging from mild tonsillitis to invasive necrotising fasciitis, sepsis and toxic shock syndrome. GAS also induces severe long-lasting autoimmune disease, including rheumatic heart disease. Annually, GAS infections kill > 500,000 people worldwide. While antibiotics are considered a reliable first line of defence against GAS infections, globally emerging antimicrobial resistance is an enormous threat. The WHO has included GAS in its vaccine priority list to finally reduce the high mortality and morbidity. We will use our developed novel modular system to produce the first dual-acting and lowcost GAS vaccine candidates targeting all > 150 GAS strains. Our approach provides the first robust and affordable solution to target and prevent GAS infections, urgently required for the global population and in particular the people in low-income countries.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Humans","Streptococcal Infections","Streptococcal Vaccines","Streptococcus pyogenes"]} -{"id":"360G-Wellcome-221586_Z_20_Z","title":"\u2018DuoChol: A low-cost, thermostable dry formulation whole-cell / B-subunit enterocoated capsule oral cholera vaccine.\u2019","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221586/Z/20/Z","description":"\"The Project aims at completion of the preclinical development of a new, improved oral cholera vaccine (OCV), DuoChol. This is a proposed thermostable OCV consisting of a lyophilized mixture of formalin-killed V. cholerae O1 Ogawa and Inaba strain whole-cells and cholera toxin B-subunit (rCTB) formulated in an enterocoated capsule. The two strains are isogenic except for the single serotype determining wbeT gene, and this allows them to be co-cultured to high density, which together with inexpensive high-yield rCTB production ensures low-cost manufacturing. The Project will build a solid platform for the subsequent clinical development of DuoChol, whose affordable cost, practical formulation and higher efficacy compared with current OCVs will make this a very attractive OCV for use in national cholera control programs and ideal for use in cholera outbreaks where rapid deployment and maximal early efficacy is of the essence.","plannedDates":[{"endDate":"2022-07-29T00:00:00+00:00","startDate":"2021-03-01T00:00:00+00:00","startDateDateOnly":"2021-03-01","endDateDateOnly":"2022-07-29"}],"amountAwarded":1130853,"Financial Year":"2019/20","Lead Applicant":"Prof Jan Holmgren","grantProgramme":[{"title":"Innovations AIGH Enterics Flagship ","title_keyword":"Innovations AIGH Enterics Flagship "}],"Applicant Surname":"Holmgren","Partnership Value":1130853,"Approval Committee":"Science, Innovation and Translation Programme Advisory Group","Other Applicant(s)":"Dr Michael Lebens, Dr Manuela Terrinoni, Dr Stefan Nordqvist","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Gothenburg","name":"University of Gothenburg","addressCountry":"Sweden","id_and_name":"[\"University of Gothenburg\", \"360G-Wellcome-ORG:University-of-Gothenburg\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Gothenburg","name":"University of Gothenburg"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"\u2018DuoChol: A low-cost, thermostable dry formulation whole-cell / B-subunit enterocoated capsule oral cholera vaccine.\u2019 \"The Project aims at completion of the preclinical development of a new, improved oral cholera vaccine (OCV), DuoChol. This is a proposed thermostable OCV consisting of a lyophilized mixture of formalin-killed V. cholerae O1 Ogawa and Inaba strain whole-cells and cholera toxin B-subunit (rCTB) formulated in an enterocoated capsule. The two strains are isogenic except for the single serotype determining wbeT gene, and this allows them to be co-cultured to high density, which together with inexpensive high-yield rCTB production ensures low-cost manufacturing. The Project will build a solid platform for the subsequent clinical development of DuoChol, whose affordable cost, practical formulation and higher efficacy compared with current OCVs will make this a very attractive OCV for use in national cholera control programs and ideal for use in cholera outbreaks where rapid deployment and maximal early efficacy is of the essence.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Administration, Oral","Cholera","Cholera Vaccines","Humans","Vibrio cholerae"]} -{"id":"360G-Wellcome-221582_Z_20_Z","title":"Predicting CBT response from fear conditioning","Region":"Greater London","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221582/Z/20/Z","description":"Responses to psychological interventions for anxiety vary greatly. Clients and clinicians want better ways to predict outcomes. One contender is fear extinction, the process through which exposure, the \"behavioural\" part of Cognitive Behavioural Therapy (CBT) is thought to work. Whilst there are robust differences in fear extinction between individuals with anxiety disorders versus controls, evidence that extinction predicts CBT response is modest. \n\n We first became interested in fear extinction as a mechanistic tool to help understand how CBT works. In order to build algorithms from numerous potential predictors, including fear extinction, we needed to undertake fear conditioning at a scale. We developed a smartphone App FLARe, that remotely delivers a fear conditioning paradigm. Our validation studies showed that fear extinction data from our App mirror that from gold-standard in-lab delivery. \n\nWe now want to test the extent to which App-delivered fear extinction data predicts CBT response. We will assess young adults with high anxiety using our App before enrolling them in CBT. We will test the strength of correlation between fear extinction and treatment outcome. We will also explore the extent to which this association is stronger in specific sub-groups (e.g. those who completed more exposure homework during treatment).\n","plannedDates":[{"endDate":"2022-04-01T00:00:00+00:00","startDate":"2020-12-01T00:00:00+00:00","startDateDateOnly":"2020-12-01","endDateDateOnly":"2022-04-01"}],"amountAwarded":347602,"Financial Year":"2019/20","Lead Applicant":"Prof Thalia Eley","grantProgramme":[{"title":"Strategic Support: Science","title_keyword":"Strategic Support: Science"}],"Applicant Surname":"Eley","Partnership Value":347602,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Dr Colette Hirsch, Prof Gerome Breen","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kings-College-London","name":"King's College London","addressCountry":"United Kingdom","id_and_name":"[\"King's College London\", \"360G-Wellcome-ORG:Kings-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Kings-College-London","name":"King's College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Predicting CBT response from fear conditioning Responses to psychological interventions for anxiety vary greatly. Clients and clinicians want better ways to predict outcomes. One contender is fear extinction, the process through which exposure, the \"behavioural\" part of Cognitive Behavioural Therapy (CBT) is thought to work. Whilst there are robust differences in fear extinction between individuals with anxiety disorders versus controls, evidence that extinction predicts CBT response is modest. \n\n We first became interested in fear extinction as a mechanistic tool to help understand how CBT works. In order to build algorithms from numerous potential predictors, including fear extinction, we needed to undertake fear conditioning at a scale. We developed a smartphone App FLARe, that remotely delivers a fear conditioning paradigm. Our validation studies showed that fear extinction data from our App mirror that from gold-standard in-lab delivery. \n\nWe now want to test the extent to which App-delivered fear extinction data predicts CBT response. We will assess young adults with high anxiety using our App before enrolling them in CBT. We will test the strength of correlation between fear extinction and treatment outcome. We will also explore the extent to which this association is stronger in specific sub-groups (e.g. those who completed more exposure homework during treatment).\n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Adult","Anxiety Disorders","Cognitive Behavioral Therapy","Extinction, Psychological","Fear","Female","Humans","Male","Mobile Applications","Smartphone","Young Adult"]} -{"id":"360G-Wellcome-221579_Z_20_Z","title":"Understanding the impact of COVID-19 on bacterial sepsis, antibiotic consumption and stewardship, and antimicrobial resistance","Region":"South East","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221579/Z/20/Z","description":"This study aims to address the following questions through a global network of hospitals: \n\n\n Is there evidence for a reduction in the total number or rates (per 1,000 inpatients) of blood cultures taken over twelve months?\n Has there been changes in antimicrobial usage (quantitative and qualitative)? \n Are there major changes in antibiotic resistance profiles from major pathogens?\n Have there been changes in antimicrobial stewardship and why? \n What is the overall change in the management of these patients?\n What is the impact of COVID-19 on infection control practices during the pandemic? \n Is there any evidence of reduction in nosocomial infections and bacterial outbreaks during the COVID-19 pandemic? \n\n\nWe will collect clinical (patient-based [severe pneumonia, ARDS, sepsis patients], hospital and microbiological data from 11 countries (UK, Switzerland, Italy, Brazil, Nigeria, Malawi, Turkey, Iran, India, Bangladesh and South Korea). \n\nOur primary outcome will be to determine if there has been a reduction in blood cultures taken. Secondary outcomes include whether 1. changes in antimicrobial usage 2. major changes in antibiotic resistance profiles from major pathogens in hospitals during COVID-19 and correlate resistance profiles with antibiotic usage. 3. changes in infection control practices and other aspects of sepsis management behaviour during the COVID-19 pandemic.\n","plannedDates":[{"endDate":"2022-08-31T00:00:00+00:00","startDate":"2020-09-01T00:00:00+00:00","startDateDateOnly":"2020-09-01","endDateDateOnly":"2022-08-31"}],"amountAwarded":765283,"Financial Year":"2019/20","Lead Applicant":"Prof Timothy Walsh","grantProgramme":[{"title":"Discretionary award \u2013 DRI","title_keyword":"Discretionary award \u2013 DRI"}],"Applicant Surname":"Walsh","Partnership Value":765283,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Prof Stephan Harbarth, Dr Catrin Moore, Dr Ly-Mee Yu, Prof Nicholas Feasey, Prof Ben Cooper, Prof Christiane Dolecek","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Understanding the impact of COVID-19 on bacterial sepsis, antibiotic consumption and stewardship, and antimicrobial resistance This study aims to address the following questions through a global network of hospitals: \n\n\n Is there evidence for a reduction in the total number or rates (per 1,000 inpatients) of blood cultures taken over twelve months?\n Has there been changes in antimicrobial usage (quantitative and qualitative)? \n Are there major changes in antibiotic resistance profiles from major pathogens?\n Have there been changes in antimicrobial stewardship and why? \n What is the overall change in the management of these patients?\n What is the impact of COVID-19 on infection control practices during the pandemic? \n Is there any evidence of reduction in nosocomial infections and bacterial outbreaks during the COVID-19 pandemic? \n\n\nWe will collect clinical (patient-based [severe pneumonia, ARDS, sepsis patients], hospital and microbiological data from 11 countries (UK, Switzerland, Italy, Brazil, Nigeria, Malawi, Turkey, Iran, India, Bangladesh and South Korea). \n\nOur primary outcome will be to determine if there has been a reduction in blood cultures taken. Secondary outcomes include whether 1. changes in antimicrobial usage 2. major changes in antibiotic resistance profiles from major pathogens in hospitals during COVID-19 and correlate resistance profiles with antibiotic usage. 3. changes in infection control practices and other aspects of sepsis management behaviour during the COVID-19 pandemic.\n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Anti-Bacterial Agents","Bacterial Infections","Cross Infection","Drug Resistance, Bacterial","Drug Utilization","Hospitals","Humans","Sepsis"]} -{"id":"360G-Wellcome-221576_Z_20_Z","title":"Unit for Health Evidence and Policy ","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221576/Z/20/Z","description":"This proposal outlines the establishment of a pilot Unit for Health Evidence and Policy within CDT-Africa, a World Bank African Centre for Excellence based at Addis Ababa University, Ethiopia. Building on strong operational research into Neglected Tropical Diseases, and existing relationships within Ethiopia\u2019s Ministry of Health, the Unit for Health Policy and Evidence will identify challenges to research uptake, pilot and evaluate an approach to improving research uptake, and produce a framework to guide future research uptake in this setting and possibly more broadly.\n\nThe pilot Unit for Health Policy and Evidence will be a 12-month project, divided into two Periods. Period 1 will comprise stakeholder consultation through two Theory of Change workshops and other interviews as necessary. During Period 2, research uptake in an NTD area defined in Period 1 will be evaluated using the Diversity Approach (see below). A Research Uptake Framework will be developed and a dissemination workshop held with key national and international stakeholders.\n \n","plannedDates":[{"endDate":"2021-12-31T00:00:00+00:00","startDate":"2021-01-01T00:00:00+00:00","startDateDateOnly":"2021-01-01","endDateDateOnly":"2021-12-31"}],"amountAwarded":48135,"Financial Year":"2019/20","Lead Applicant":"Dr Abebaw Fekadu","grantProgramme":[{"title":"Discretionary Award - Policy ","title_keyword":"Discretionary Award - Policy "}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Fekadu","Partnership Value":96271,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Addis-Ababa-University","name":"Addis Ababa University","addressCountry":"Ethiopia","id_and_name":"[\"Addis Ababa University\", \"360G-Wellcome-ORG:Addis-Ababa-University\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Addis-Ababa-University","name":"Addis Ababa University"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Unit for Health Evidence and Policy This proposal outlines the establishment of a pilot Unit for Health Evidence and Policy within CDT-Africa, a World Bank African Centre for Excellence based at Addis Ababa University, Ethiopia. Building on strong operational research into Neglected Tropical Diseases, and existing relationships within Ethiopia\u2019s Ministry of Health, the Unit for Health Policy and Evidence will identify challenges to research uptake, pilot and evaluate an approach to improving research uptake, and produce a framework to guide future research uptake in this setting and possibly more broadly.\n\nThe pilot Unit for Health Policy and Evidence will be a 12-month project, divided into two Periods. Period 1 will comprise stakeholder consultation through two Theory of Change workshops and other interviews as necessary. During Period 2, research uptake in an NTD area defined in Period 1 will be evaluated using the Diversity Approach (see below). A Research Uptake Framework will be developed and a dissemination workshop held with key national and international stakeholders.\n \n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Ethiopia","Health Policy","Humans","Pilot Projects","Policy Making","Universities"]} +{"id":"360G-Wellcome-221604_Z_20_Z","title":"Immunometabolic cross-talk in the inflamed diabetic heart","Region":"Greater London","currency":"GBP","awardDate":"2020-11-11T00:00:00+00:00","Sponsor(s)":"Prof Mark Caulfield","Internal ID":"221604/Z/20/Z","description":"Diabetic cardiomyopathy (dbCM) is a complication of type II diabetes (T2D), characterised by systemic inflammation, impaired cardiac function and disrupted metabolism. However, the impact of systemic inflammation on the development of the myocardial inflammation and cardiac metabolic derangement that lead to dbCM remain unknown. This study will address how chronic adaptive inflammation driven by systemic metabolic stress in T2D causes cardiac dysfunction. Specifically, I hypothesise that it is caused by inflammation due to T-cell infiltration and not by direct metabolic perturbations that can lead to impaired energetics (reduced PCr/ATP ratio). Specifically, the aim is to use integrated experimental approach combining metabolic analysis with T-cell phenotypic profiling in murine and human T2D to address three research challenges:\n\nA. Does infiltration of cardiotropic T-cells impair cardiac substrate plasticity and energetics in dbCM?\n\nB. Do myocardial succinate efflux and signalling via SUCNR1 promote cardiac Teff and/or Treg activation by modifying T-cell metabolism and do they enhance pro-inflammatory T-cell differentiation?\n\nC. Does stimulation of GCK-mediated glycolysis increase regulatory T-cell migration to the heart causing a switch in the nature of immune response from pro-inflammatory to immunosuppressive? Does the resultant reduction in myocardial exposure to pro-inflammatory cytokines improve cardiac function and mitochondrial performance? \n","plannedDates":[{"endDate":"2025-01-10T00:00:00+00:00","startDate":"2021-01-11T00:00:00+00:00","startDateDateOnly":"2021-01-11","endDateDateOnly":"2025-01-10"}],"amountAwarded":630613,"Financial Year":"2020/21","Lead Applicant":"Dr Dunja Aksentijevic","grantProgramme":[{"title":"Career Re-Entry Fellowship","title_keyword":"Career Re-Entry Fellowship"}],"Applicant Surname":"Aksentijevic","Partnership Value":630613,"Approval Committee":"Basic Science Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Queen-Mary-University-of-London","name":"Queen Mary University of London","addressCountry":"United Kingdom","id_and_name":"[\"Queen Mary University of London\", \"360G-Wellcome-ORG:Queen-Mary-University-of-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Queen-Mary-University-of-London","name":"Queen Mary University of London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Immunometabolic cross-talk in the inflamed diabetic heart Diabetic cardiomyopathy (dbCM) is a complication of type II diabetes (T2D), characterised by systemic inflammation, impaired cardiac function and disrupted metabolism. However, the impact of systemic inflammation on the development of the myocardial inflammation and cardiac metabolic derangement that lead to dbCM remain unknown. This study will address how chronic adaptive inflammation driven by systemic metabolic stress in T2D causes cardiac dysfunction. Specifically, I hypothesise that it is caused by inflammation due to T-cell infiltration and not by direct metabolic perturbations that can lead to impaired energetics (reduced PCr/ATP ratio). Specifically, the aim is to use integrated experimental approach combining metabolic analysis with T-cell phenotypic profiling in murine and human T2D to address three research challenges:\n\nA. Does infiltration of cardiotropic T-cells impair cardiac substrate plasticity and energetics in dbCM?\n\nB. Do myocardial succinate efflux and signalling via SUCNR1 promote cardiac Teff and/or Treg activation by modifying T-cell metabolism and do they enhance pro-inflammatory T-cell differentiation?\n\nC. Does stimulation of GCK-mediated glycolysis increase regulatory T-cell migration to the heart causing a switch in the nature of immune response from pro-inflammatory to immunosuppressive? Does the resultant reduction in myocardial exposure to pro-inflammatory cytokines improve cardiac function and mitochondrial performance? \n","awardDateDateOnly":"2020-11-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Checklist","Electronic Health Records","Humans","Neural Networks, Computer","Renal Replacement Therapy","Workflow"]} +{"id":"360G-Wellcome-221598_Z_20_Z","title":"Oral Ketamine Capsules - A new potential treatment for Depression. A pharmacokinetic and pharmacodynamic assessment of Ketamine and Metabolites in a dose-escalating, placebo-controlled clinical trial in healthy subjects.","Region":"Scotland","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221598/Z/20/Z","description":"Neurocentrx has developed oral capsule formulations of Ketamine, aiming to be new treatments for Depression. Ketamine is a synthetic drug created in the 1960\u2019s. It is on the \"essential medicine\" list of the World Health Organisation (WHO), approved and licensed by health regulators worldwide as an injectable anaesthetic. More recently, and at sub-anaesthetic doses, clinical trials have shown that some patients with depression have a rapid response to injectable ketamine (hours or days). Most other anti-depressant medicines take many weeks to work. No oral ketamine products are currently available as a licensed medicine worldwide. Our project will assess oral capsules in healthy people in a clinical trial. We will assess absorption and excretion with increasing doses of drug and measure any side-effects. These data will be essential to accurately plan trials in depression patients where we will then look for benefits. Oral capsules could be used at home, and are hoped to be a cheaper treatment option, with fewer side-effects for patients. The summary above may be amended from time to time by mutual agreement of the Parties. For this clause agreement by email will be sufficient to render a valid amendment to the summary).","plannedDates":[{"endDate":"2022-04-10T00:00:00+00:00","startDate":"2020-11-09T00:00:00+00:00","startDateDateOnly":"2020-11-09","endDateDateOnly":"2022-04-10"}],"amountAwarded":498326,"Financial Year":"2019/20","Lead Applicant":"Dr Carmel Reilly","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Reilly","Partnership Value":498326,"Approval Committee":"Innovator Awards Advisory Group","Other Applicant(s)":"Dr Mario Juruena","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Neurocentrx-Pharma-Ltd","name":"Neurocentrx Pharma Ltd","addressCountry":"United Kingdom","id_and_name":"[\"Neurocentrx Pharma Ltd\", \"360G-Wellcome-ORG:Neurocentrx-Pharma-Ltd\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Neurocentrx-Pharma-Ltd","name":"Neurocentrx Pharma Ltd"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Oral Ketamine Capsules - A new potential treatment for Depression. A pharmacokinetic and pharmacodynamic assessment of Ketamine and Metabolites in a dose-escalating, placebo-controlled clinical trial in healthy subjects. Neurocentrx has developed oral capsule formulations of Ketamine, aiming to be new treatments for Depression. Ketamine is a synthetic drug created in the 1960\u2019s. It is on the \"essential medicine\" list of the World Health Organisation (WHO), approved and licensed by health regulators worldwide as an injectable anaesthetic. More recently, and at sub-anaesthetic doses, clinical trials have shown that some patients with depression have a rapid response to injectable ketamine (hours or days). Most other anti-depressant medicines take many weeks to work. No oral ketamine products are currently available as a licensed medicine worldwide. Our project will assess oral capsules in healthy people in a clinical trial. We will assess absorption and excretion with increasing doses of drug and measure any side-effects. These data will be essential to accurately plan trials in depression patients where we will then look for benefits. Oral capsules could be used at home, and are hoped to be a cheaper treatment option, with fewer side-effects for patients. The summary above may be amended from time to time by mutual agreement of the Parties. For this clause agreement by email will be sufficient to render a valid amendment to the summary).","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Cryoelectron Microscopy","DNA-Directed RNA Polymerases","Microscopy","Molecular Dynamics Simulation"]} +{"id":"360G-Wellcome-221597_Z_20_Z","title":"The evaluation of novel GBS conjugates prepared from GBS capsular polysaccharides and GBS conserved surface proteins\u2019","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221597/Z/20/Z","description":"Group B Streptococcus (GBS) bacterial infection is a major health concern and a leading cause of sepsis and meningitis in infants, particularly in Africa. A promising prevention for GBS infection in newborns is maternal immunization with a GBS vaccine. Currently no vaccine for GBS is available. Several conjugate GBS vaccines using GBS surface-expressed polysaccharides linked to carrier proteins are under development. We are proposing a novel vaccine design using GBS polysaccharides conjugated to GBS conserved surface proteins which induce immune responses in infected individuals, making them potential candidates as carrier proteins for novel GBS vaccines. It combines two virulence factors of GBS with the potential to provide not only enhanced overall protection compared to traditional conjugate vaccines but also to potentially provide protection against those serotypes not included in the vaccine. It could lead to the development of an affordable and cost-effective vaccine that protects against all GBS serotypes.","plannedDates":[{"endDate":"2022-10-30T00:00:00+00:00","startDate":"2021-05-03T00:00:00+00:00","startDateDateOnly":"2021-05-03","endDateDateOnly":"2022-10-30"}],"amountAwarded":398043,"Financial Year":"2019/20","Lead Applicant":"Dr Seanette Wilson","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Wilson","Partnership Value":398043,"Approval Committee":"Innovator Awards Advisory Group","Other Applicant(s)":"Dr Gaurav Kwatra","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:The-Biovac-Institute","name":"The Biovac Institute","addressCountry":"South Africa","id_and_name":"[\"The Biovac Institute\", \"360G-Wellcome-ORG:The-Biovac-Institute\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:The-Biovac-Institute","name":"The Biovac Institute"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"The evaluation of novel GBS conjugates prepared from GBS capsular polysaccharides and GBS conserved surface proteins\u2019 Group B Streptococcus (GBS) bacterial infection is a major health concern and a leading cause of sepsis and meningitis in infants, particularly in Africa. A promising prevention for GBS infection in newborns is maternal immunization with a GBS vaccine. Currently no vaccine for GBS is available. Several conjugate GBS vaccines using GBS surface-expressed polysaccharides linked to carrier proteins are under development. We are proposing a novel vaccine design using GBS polysaccharides conjugated to GBS conserved surface proteins which induce immune responses in infected individuals, making them potential candidates as carrier proteins for novel GBS vaccines. It combines two virulence factors of GBS with the potential to provide not only enhanced overall protection compared to traditional conjugate vaccines but also to potentially provide protection against those serotypes not included in the vaccine. It could lead to the development of an affordable and cost-effective vaccine that protects against all GBS serotypes.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Chromatin","Chromatin Assembly and Disassembly","Cryoelectron Microscopy","DNA","Fluorescence Resonance Energy Transfer","Humans","Models, Molecular","Nucleosomes"]} +{"id":"360G-Wellcome-221595_Z_20_Z","title":"Preclinical Toxicology Testing and IND application for a Novel Cholera Conjugate Vaccine","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221595/Z/20/Z","description":"Cholera is a disease of inequity that continues to disproportionately affect the world\u2019s poorest and\nmost vulnerable people. An oral cholera vaccine (OCV) is available and in use around the world,\nbut it has lower efficacy in young children than in adults and a relatively short duration of protection\nnecessitating re-vaccination every few years. We are developing a new conjugate vaccine that\noffers the promise of improved efficacy in all age groups, including those less than 5 years, and an\nextended duration of protection, thus reducing the requirements for repetitive vaccination to sustain\npopulation immunity. It can be implemented in place of OCV or as a complementary tool to prevent\nor limit outbreaks in high risk settings, and build enduring population immunity that will costeffectively\ncontrol cholera over the decades required to build definitive public health capacities in at\nrisk countries.","plannedDates":[{"endDate":"2021-10-31T00:00:00+00:00","startDate":"2020-11-01T00:00:00+00:00","startDateDateOnly":"2020-11-01","endDateDateOnly":"2021-10-31"}],"amountAwarded":456865,"Financial Year":"2019/20","Lead Applicant":"Dr Julia Lynch","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Lynch","Partnership Value":456865,"Approval Committee":"Innovator Awards Advisory Group","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:International-Vaccine-Institute","name":"International Vaccine Institute","addressCountry":"Korea, South","id_and_name":"[\"International Vaccine Institute\", \"360G-Wellcome-ORG:International-Vaccine-Institute\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:International-Vaccine-Institute","name":"International Vaccine Institute"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Preclinical Toxicology Testing and IND application for a Novel Cholera Conjugate Vaccine Cholera is a disease of inequity that continues to disproportionately affect the world\u2019s poorest and\nmost vulnerable people. An oral cholera vaccine (OCV) is available and in use around the world,\nbut it has lower efficacy in young children than in adults and a relatively short duration of protection\nnecessitating re-vaccination every few years. We are developing a new conjugate vaccine that\noffers the promise of improved efficacy in all age groups, including those less than 5 years, and an\nextended duration of protection, thus reducing the requirements for repetitive vaccination to sustain\npopulation immunity. It can be implemented in place of OCV or as a complementary tool to prevent\nor limit outbreaks in high risk settings, and build enduring population immunity that will costeffectively\ncontrol cholera over the decades required to build definitive public health capacities in at\nrisk countries.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Animals","Crystallography, X-Ray","Epilepsy","Humans","Models, Molecular","Mutation"]} +{"id":"360G-Wellcome-221590_Z_20_Z","title":"AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment ","Region":"North West","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221590/Z/20/Z","description":"Conventional evaluation of new medicines is not fast enough for a pandemic. Our aim is to accelerate this process, rapidly identifying which drugs are safe and potentially effective treatments for COVID-19. AGILE is an innovative, multi-arm, multi-dose, multi-stage Phase I/IIa Bayesian adaptive platform protocol to evaluate experimental COVID-19 therapies, and to funnel plausible candidates into large Phase IIb/III trials such as RECOVERY and SOLIDARITY. We will efficiently eliminate candidates with little or no prospect of clinical success.\n\nAGILE will recruit COVID-19 patients into very early phase clinical studies, including first-in-human. The innovative design allows us to move seamlessly from first-in-human use to finding the optimal dose for COVID-19 patients. The trial is pragmatic (requiring only small numbers of patients), adaptive (so that the right drug is tested in the right group of COVID-19 patients, either in the community or in hospital) and statistically efficient (so that several drugs can be tested in parallel, making best use of a small number of patients). Our primary focus is population-scalable antiviral drugs for early treatment of COVID-19, for which we will recruit primarily in the community. AGILE has full regulatory and ethics approvals in the UK.\n \n","plannedDates":[{"endDate":"2023-01-31T00:00:00+00:00","startDate":"2021-02-01T00:00:00+00:00","startDateDateOnly":"2021-02-01","endDateDateOnly":"2023-01-31"}],"amountAwarded":3069077,"Financial Year":"2019/20","Lead Applicant":"Prof Saye Khoo","grantProgramme":[{"title":"Therapeutics Accelerator ","title_keyword":"Therapeutics Accelerator "}],"Applicant Surname":"Khoo","Partnership Value":3069077,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Dr Richard Fitzgerald, Prof Gareth Griffiths, Prof Sir Munir Pirmohamed, Dr Mohammed Lamorde, Prof Catherine Orrell, Prof David Lalloo, Dr Shevin Jacob, Dr Thomas Fletcher, Prof Andrew Owen, Prof Francois Venter, Prof Thomas Jaki, Dr Bella Starling, Prof William Greenhalf, Sir Michael Jacobs","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Liverpool","name":"University of Liverpool","addressCountry":"United Kingdom","id_and_name":"[\"University of Liverpool\", \"360G-Wellcome-ORG:University-of-Liverpool\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Liverpool","name":"University of Liverpool"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment Conventional evaluation of new medicines is not fast enough for a pandemic. Our aim is to accelerate this process, rapidly identifying which drugs are safe and potentially effective treatments for COVID-19. AGILE is an innovative, multi-arm, multi-dose, multi-stage Phase I/IIa Bayesian adaptive platform protocol to evaluate experimental COVID-19 therapies, and to funnel plausible candidates into large Phase IIb/III trials such as RECOVERY and SOLIDARITY. We will efficiently eliminate candidates with little or no prospect of clinical success.\n\nAGILE will recruit COVID-19 patients into very early phase clinical studies, including first-in-human. The innovative design allows us to move seamlessly from first-in-human use to finding the optimal dose for COVID-19 patients. The trial is pragmatic (requiring only small numbers of patients), adaptive (so that the right drug is tested in the right group of COVID-19 patients, either in the community or in hospital) and statistically efficient (so that several drugs can be tested in parallel, making best use of a small number of patients). Our primary focus is population-scalable antiviral drugs for early treatment of COVID-19, for which we will recruit primarily in the community. AGILE has full regulatory and ethics approvals in the UK.\n \n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Humans","Models, Biological","Phenotype"]} +{"id":"360G-Wellcome-221589_Z_20_Z","title":"Development of a Universal Group A Streptococcus Glycoconjugate Vaccine","Region":"Scotland","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221589/Z/20/Z","description":"The pathogenic bacterium Group A Streptococcus (GAS) causes a range of infections, ranging from mild tonsillitis to invasive necrotising fasciitis, sepsis and toxic shock syndrome. GAS also induces severe long-lasting autoimmune disease, including rheumatic heart disease. Annually, GAS infections kill > 500,000 people worldwide. While antibiotics are considered a reliable first line of defence against GAS infections, globally emerging antimicrobial resistance is an enormous threat. The WHO has included GAS in its vaccine priority list to finally reduce the high mortality and morbidity. We will use our developed novel modular system to produce the first dual-acting and lowcost GAS vaccine candidates targeting all > 150 GAS strains. Our approach provides the first robust and affordable solution to target and prevent GAS infections, urgently required for the global population and in particular the people in low-income countries.","plannedDates":[{"endDate":"2023-09-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00","startDateDateOnly":"2021-10-01","endDateDateOnly":"2023-09-30"}],"amountAwarded":402298,"Financial Year":"2019/20","Lead Applicant":"Dr Helge Dorfmueller","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Dorfmueller","Partnership Value":402298,"Approval Committee":"Innovator Awards Advisory Group","Other Applicant(s)":"Prof Brendan Wren","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Dundee","name":"University of Dundee","addressCountry":"United Kingdom","id_and_name":"[\"University of Dundee\", \"360G-Wellcome-ORG:University-of-Dundee\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Dundee","name":"University of Dundee"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Development of a Universal Group A Streptococcus Glycoconjugate Vaccine The pathogenic bacterium Group A Streptococcus (GAS) causes a range of infections, ranging from mild tonsillitis to invasive necrotising fasciitis, sepsis and toxic shock syndrome. GAS also induces severe long-lasting autoimmune disease, including rheumatic heart disease. Annually, GAS infections kill > 500,000 people worldwide. While antibiotics are considered a reliable first line of defence against GAS infections, globally emerging antimicrobial resistance is an enormous threat. The WHO has included GAS in its vaccine priority list to finally reduce the high mortality and morbidity. We will use our developed novel modular system to produce the first dual-acting and lowcost GAS vaccine candidates targeting all > 150 GAS strains. Our approach provides the first robust and affordable solution to target and prevent GAS infections, urgently required for the global population and in particular the people in low-income countries.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Hospitals, University","Humans","Photography","Universities"]} +{"id":"360G-Wellcome-221586_Z_20_Z","title":"\u2018DuoChol: A low-cost, thermostable dry formulation whole-cell / B-subunit enterocoated capsule oral cholera vaccine.\u2019","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221586/Z/20/Z","description":"\"The Project aims at completion of the preclinical development of a new, improved oral cholera vaccine (OCV), DuoChol. This is a proposed thermostable OCV consisting of a lyophilized mixture of formalin-killed V. cholerae O1 Ogawa and Inaba strain whole-cells and cholera toxin B-subunit (rCTB) formulated in an enterocoated capsule. The two strains are isogenic except for the single serotype determining wbeT gene, and this allows them to be co-cultured to high density, which together with inexpensive high-yield rCTB production ensures low-cost manufacturing. The Project will build a solid platform for the subsequent clinical development of DuoChol, whose affordable cost, practical formulation and higher efficacy compared with current OCVs will make this a very attractive OCV for use in national cholera control programs and ideal for use in cholera outbreaks where rapid deployment and maximal early efficacy is of the essence.","plannedDates":[{"endDate":"2022-07-29T00:00:00+00:00","startDate":"2021-03-01T00:00:00+00:00","startDateDateOnly":"2021-03-01","endDateDateOnly":"2022-07-29"}],"amountAwarded":1130853,"Financial Year":"2019/20","Lead Applicant":"Prof Jan Holmgren","grantProgramme":[{"title":"Innovations AIGH Enterics Flagship ","title_keyword":"Innovations AIGH Enterics Flagship "}],"Applicant Surname":"Holmgren","Partnership Value":1130853,"Approval Committee":"Science, Innovation and Translation Programme Advisory Group","Other Applicant(s)":"Dr Michael Lebens, Dr Manuela Terrinoni, Dr Stefan Nordqvist","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Gothenburg","name":"University of Gothenburg","addressCountry":"Sweden","id_and_name":"[\"University of Gothenburg\", \"360G-Wellcome-ORG:University-of-Gothenburg\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Gothenburg","name":"University of Gothenburg"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"\u2018DuoChol: A low-cost, thermostable dry formulation whole-cell / B-subunit enterocoated capsule oral cholera vaccine.\u2019 \"The Project aims at completion of the preclinical development of a new, improved oral cholera vaccine (OCV), DuoChol. This is a proposed thermostable OCV consisting of a lyophilized mixture of formalin-killed V. cholerae O1 Ogawa and Inaba strain whole-cells and cholera toxin B-subunit (rCTB) formulated in an enterocoated capsule. The two strains are isogenic except for the single serotype determining wbeT gene, and this allows them to be co-cultured to high density, which together with inexpensive high-yield rCTB production ensures low-cost manufacturing. The Project will build a solid platform for the subsequent clinical development of DuoChol, whose affordable cost, practical formulation and higher efficacy compared with current OCVs will make this a very attractive OCV for use in national cholera control programs and ideal for use in cholera outbreaks where rapid deployment and maximal early efficacy is of the essence.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Antibodies, Monoclonal","Developing Countries","Humans","Rabies"]} +{"id":"360G-Wellcome-221582_Z_20_Z","title":"Predicting CBT response from fear conditioning","Region":"Greater London","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221582/Z/20/Z","description":"Responses to psychological interventions for anxiety vary greatly. Clients and clinicians want better ways to predict outcomes. One contender is fear extinction, the process through which exposure, the \"behavioural\" part of Cognitive Behavioural Therapy (CBT) is thought to work. Whilst there are robust differences in fear extinction between individuals with anxiety disorders versus controls, evidence that extinction predicts CBT response is modest. \n\n We first became interested in fear extinction as a mechanistic tool to help understand how CBT works. In order to build algorithms from numerous potential predictors, including fear extinction, we needed to undertake fear conditioning at a scale. We developed a smartphone App FLARe, that remotely delivers a fear conditioning paradigm. Our validation studies showed that fear extinction data from our App mirror that from gold-standard in-lab delivery. \n\nWe now want to test the extent to which App-delivered fear extinction data predicts CBT response. We will assess young adults with high anxiety using our App before enrolling them in CBT. We will test the strength of correlation between fear extinction and treatment outcome. We will also explore the extent to which this association is stronger in specific sub-groups (e.g. those who completed more exposure homework during treatment).\n","plannedDates":[{"endDate":"2022-04-01T00:00:00+00:00","startDate":"2020-12-01T00:00:00+00:00","startDateDateOnly":"2020-12-01","endDateDateOnly":"2022-04-01"}],"amountAwarded":347602,"Financial Year":"2019/20","Lead Applicant":"Prof Thalia Eley","grantProgramme":[{"title":"Strategic Support: Science","title_keyword":"Strategic Support: Science"}],"Applicant Surname":"Eley","Partnership Value":347602,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Dr Colette Hirsch, Prof Gerome Breen","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Kings-College-London","name":"King's College London","addressCountry":"United Kingdom","id_and_name":"[\"King's College London\", \"360G-Wellcome-ORG:Kings-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Kings-College-London","name":"King's College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Predicting CBT response from fear conditioning Responses to psychological interventions for anxiety vary greatly. Clients and clinicians want better ways to predict outcomes. One contender is fear extinction, the process through which exposure, the \"behavioural\" part of Cognitive Behavioural Therapy (CBT) is thought to work. Whilst there are robust differences in fear extinction between individuals with anxiety disorders versus controls, evidence that extinction predicts CBT response is modest. \n\n We first became interested in fear extinction as a mechanistic tool to help understand how CBT works. In order to build algorithms from numerous potential predictors, including fear extinction, we needed to undertake fear conditioning at a scale. We developed a smartphone App FLARe, that remotely delivers a fear conditioning paradigm. Our validation studies showed that fear extinction data from our App mirror that from gold-standard in-lab delivery. \n\nWe now want to test the extent to which App-delivered fear extinction data predicts CBT response. We will assess young adults with high anxiety using our App before enrolling them in CBT. We will test the strength of correlation between fear extinction and treatment outcome. We will also explore the extent to which this association is stronger in specific sub-groups (e.g. those who completed more exposure homework during treatment).\n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Africa","Child","Female","Humans","Male"]} +{"id":"360G-Wellcome-221579_Z_20_Z","title":"Understanding the impact of COVID-19 on bacterial sepsis, antibiotic consumption and stewardship, and antimicrobial resistance","Region":"South East","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221579/Z/20/Z","description":"This study aims to address the following questions through a global network of hospitals: \n\n\n Is there evidence for a reduction in the total number or rates (per 1,000 inpatients) of blood cultures taken over twelve months?\n Has there been changes in antimicrobial usage (quantitative and qualitative)? \n Are there major changes in antibiotic resistance profiles from major pathogens?\n Have there been changes in antimicrobial stewardship and why? \n What is the overall change in the management of these patients?\n What is the impact of COVID-19 on infection control practices during the pandemic? \n Is there any evidence of reduction in nosocomial infections and bacterial outbreaks during the COVID-19 pandemic? \n\n\nWe will collect clinical (patient-based [severe pneumonia, ARDS, sepsis patients], hospital and microbiological data from 11 countries (UK, Switzerland, Italy, Brazil, Nigeria, Malawi, Turkey, Iran, India, Bangladesh and South Korea). \n\nOur primary outcome will be to determine if there has been a reduction in blood cultures taken. Secondary outcomes include whether 1. changes in antimicrobial usage 2. major changes in antibiotic resistance profiles from major pathogens in hospitals during COVID-19 and correlate resistance profiles with antibiotic usage. 3. changes in infection control practices and other aspects of sepsis management behaviour during the COVID-19 pandemic.\n","plannedDates":[{"endDate":"2022-08-31T00:00:00+00:00","startDate":"2020-09-01T00:00:00+00:00","startDateDateOnly":"2020-09-01","endDateDateOnly":"2022-08-31"}],"amountAwarded":765283,"Financial Year":"2019/20","Lead Applicant":"Prof Timothy Walsh","grantProgramme":[{"title":"Discretionary award \u2013 DRI","title_keyword":"Discretionary award \u2013 DRI"}],"Applicant Surname":"Walsh","Partnership Value":765283,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Prof Stephan Harbarth, Dr Catrin Moore, Dr Ly-Mee Yu, Prof Nicholas Feasey, Prof Ben Cooper, Prof Christiane Dolecek","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Understanding the impact of COVID-19 on bacterial sepsis, antibiotic consumption and stewardship, and antimicrobial resistance This study aims to address the following questions through a global network of hospitals: \n\n\n Is there evidence for a reduction in the total number or rates (per 1,000 inpatients) of blood cultures taken over twelve months?\n Has there been changes in antimicrobial usage (quantitative and qualitative)? \n Are there major changes in antibiotic resistance profiles from major pathogens?\n Have there been changes in antimicrobial stewardship and why? \n What is the overall change in the management of these patients?\n What is the impact of COVID-19 on infection control practices during the pandemic? \n Is there any evidence of reduction in nosocomial infections and bacterial outbreaks during the COVID-19 pandemic? \n\n\nWe will collect clinical (patient-based [severe pneumonia, ARDS, sepsis patients], hospital and microbiological data from 11 countries (UK, Switzerland, Italy, Brazil, Nigeria, Malawi, Turkey, Iran, India, Bangladesh and South Korea). \n\nOur primary outcome will be to determine if there has been a reduction in blood cultures taken. Secondary outcomes include whether 1. changes in antimicrobial usage 2. major changes in antibiotic resistance profiles from major pathogens in hospitals during COVID-19 and correlate resistance profiles with antibiotic usage. 3. changes in infection control practices and other aspects of sepsis management behaviour during the COVID-19 pandemic.\n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Disabled Persons","Humans","Research","Social Sciences","Universities"]} +{"id":"360G-Wellcome-221576_Z_20_Z","title":"Unit for Health Evidence and Policy ","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221576/Z/20/Z","description":"This proposal outlines the establishment of a pilot Unit for Health Evidence and Policy within CDT-Africa, a World Bank African Centre for Excellence based at Addis Ababa University, Ethiopia. Building on strong operational research into Neglected Tropical Diseases, and existing relationships within Ethiopia\u2019s Ministry of Health, the Unit for Health Policy and Evidence will identify challenges to research uptake, pilot and evaluate an approach to improving research uptake, and produce a framework to guide future research uptake in this setting and possibly more broadly.\n\nThe pilot Unit for Health Policy and Evidence will be a 12-month project, divided into two Periods. Period 1 will comprise stakeholder consultation through two Theory of Change workshops and other interviews as necessary. During Period 2, research uptake in an NTD area defined in Period 1 will be evaluated using the Diversity Approach (see below). A Research Uptake Framework will be developed and a dissemination workshop held with key national and international stakeholders.\n \n","plannedDates":[{"endDate":"2021-12-31T00:00:00+00:00","startDate":"2021-01-01T00:00:00+00:00","startDateDateOnly":"2021-01-01","endDateDateOnly":"2021-12-31"}],"amountAwarded":48135,"Financial Year":"2019/20","Lead Applicant":"Dr Abebaw Fekadu","grantProgramme":[{"title":"Discretionary Award - Policy ","title_keyword":"Discretionary Award - Policy "}],"Partnership Name":"NIHR/Wellcome Global health Partnership","Applicant Surname":"Fekadu","Partnership Value":96271,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Addis-Ababa-University","name":"Addis Ababa University","addressCountry":"Ethiopia","id_and_name":"[\"Addis Ababa University\", \"360G-Wellcome-ORG:Addis-Ababa-University\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Addis-Ababa-University","name":"Addis Ababa University"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Unit for Health Evidence and Policy This proposal outlines the establishment of a pilot Unit for Health Evidence and Policy within CDT-Africa, a World Bank African Centre for Excellence based at Addis Ababa University, Ethiopia. Building on strong operational research into Neglected Tropical Diseases, and existing relationships within Ethiopia\u2019s Ministry of Health, the Unit for Health Policy and Evidence will identify challenges to research uptake, pilot and evaluate an approach to improving research uptake, and produce a framework to guide future research uptake in this setting and possibly more broadly.\n\nThe pilot Unit for Health Policy and Evidence will be a 12-month project, divided into two Periods. Period 1 will comprise stakeholder consultation through two Theory of Change workshops and other interviews as necessary. During Period 2, research uptake in an NTD area defined in Period 1 will be evaluated using the Diversity Approach (see below). A Research Uptake Framework will be developed and a dissemination workshop held with key national and international stakeholders.\n \n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}},"tags":["Biomedical Research","Humanities","Humans","Inventions","Laboratories","Research"]} +{"id":"360G-Wellcome-221575_Z_20_Z","title":"AVID-CC Adalimumab for COVID19 in community care","Region":"South East","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221575/Z/20/Z","description":"While the first wave of COVID-19 is passing, we have yet to identify effective treatments. Most treatments have been used late in the illness. There is a pressing need to identify treatments delivered in community settings that avoid hospital admission. Novel immunomodulatory treatments have a well understood safety profile but are not suitable for studies such as Principle which rely on remote assessment. Hospital at home is a developing networ; teams of consultant physicians and nurses deliver high intensity care in community settings, commonly using point of care diagnostics. This provides a suitable framework for evaluation of novel therapies. This approach has parallels with healthcare systems employed in low and middle income countries and so the results will directly inform the delivery of interventions in these settings. \n\nMultiple strands of evidence identify TNFa as an important mediator of the hyperinflammatory state that is associated with poor outcome. Early intervention with anti-TNF therapy has the potential to substantially mitigate its effects and improve outcomes. Adalimumab is an established subcutaneous anti-TNF therapy. We propose a randomised dose ranging study in community settings to establish whether it can mitigate progression to respiratory failure (requirement for oxygen, non invasive and invasive ventilation) or death. \n\n \n","plannedDates":[{"endDate":"2021-12-31T00:00:00+00:00","startDate":"2020-08-01T00:00:00+00:00","startDateDateOnly":"2020-08-01","endDateDateOnly":"2021-12-31"}],"amountAwarded":1495762,"Financial Year":"2019/20","Lead Applicant":"Prof Duncan Richards","grantProgramme":[{"title":"Therapeutics Accelerator ","title_keyword":"Therapeutics Accelerator "}],"Applicant Surname":"Richards","Partnership Value":1495762,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Prof Sir Marc Feldmann, Dr Matthew Rowland, Prof Jonathan Cook, Prof Daniel Lasserson","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"AVID-CC Adalimumab for COVID19 in community care While the first wave of COVID-19 is passing, we have yet to identify effective treatments. Most treatments have been used late in the illness. There is a pressing need to identify treatments delivered in community settings that avoid hospital admission. Novel immunomodulatory treatments have a well understood safety profile but are not suitable for studies such as Principle which rely on remote assessment. Hospital at home is a developing networ; teams of consultant physicians and nurses deliver high intensity care in community settings, commonly using point of care diagnostics. This provides a suitable framework for evaluation of novel therapies. This approach has parallels with healthcare systems employed in low and middle income countries and so the results will directly inform the delivery of interventions in these settings. \n\nMultiple strands of evidence identify TNFa as an important mediator of the hyperinflammatory state that is associated with poor outcome. Early intervention with anti-TNF therapy has the potential to substantially mitigate its effects and improve outcomes. Adalimumab is an established subcutaneous anti-TNF therapy. We propose a randomised dose ranging study in community settings to establish whether it can mitigate progression to respiratory failure (requirement for oxygen, non invasive and invasive ventilation) or death. \n\n \n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-221574_Z_20_Z","title":"Wellcome Longitudinal Population Study COVID-19 Steering Group and Secretariat","Region":"South West","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221574/Z/20/Z","description":"Our objective is to provide an efficient coordinating body (\"secretariat\") for the continued development, deployment, collection and analysis of a shared COVID-19 questionnaire across UK cohorts.\n\nThe value of undertaking this in multiple longitudinal UK cohorts is that data can be collected in extremely well characterised members of the population across a wide demographic range who are already engaged in research, who have had data and biological samples collected on them, who have an established collection of record linked data already record linked and who sit behind supported infrastructure able to undertake novel data collection and research. Each of these cohorts is research active and collectively offers a depth or domain expertise not available within any one cohort, including that of UK Biobank. In this first coordination of COVID-19 research in deeply characterised UK cohorts, we identified the added value of a core questionnaire prospectively aligned to capture data pertinent to understanding COVID-19, as well as the direct and indirect consequences of the pandemic on health, wellbeing, social and economic outcomes.\n","plannedDates":[{"endDate":"2021-06-30T00:00:00+00:00","startDate":"2020-07-01T00:00:00+00:00","startDateDateOnly":"2020-07-01","endDateDateOnly":"2021-06-30"}],"amountAwarded":120585,"Financial Year":"2019/20","Lead Applicant":"Prof Nicholas Timpson","grantProgramme":[{"title":"Strategic Support: Science","title_keyword":"Strategic Support: Science"}],"Applicant Surname":"Timpson","Partnership Value":120585,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Bristol","name":"University of Bristol","addressCountry":"United Kingdom","id_and_name":"[\"University of Bristol\", \"360G-Wellcome-ORG:University-of-Bristol\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Bristol","name":"University of Bristol"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Wellcome Longitudinal Population Study COVID-19 Steering Group and Secretariat Our objective is to provide an efficient coordinating body (\"secretariat\") for the continued development, deployment, collection and analysis of a shared COVID-19 questionnaire across UK cohorts.\n\nThe value of undertaking this in multiple longitudinal UK cohorts is that data can be collected in extremely well characterised members of the population across a wide demographic range who are already engaged in research, who have had data and biological samples collected on them, who have an established collection of record linked data already record linked and who sit behind supported infrastructure able to undertake novel data collection and research. Each of these cohorts is research active and collectively offers a depth or domain expertise not available within any one cohort, including that of UK Biobank. In this first coordination of COVID-19 research in deeply characterised UK cohorts, we identified the added value of a core questionnaire prospectively aligned to capture data pertinent to understanding COVID-19, as well as the direct and indirect consequences of the pandemic on health, wellbeing, social and economic outcomes.\n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-221572_Z_20_Z","title":"\u2018Harnessing endogenous mechanisms to promote cardiac regeneration\u2019","Region":"South East","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221572/Z/20/Z","description":"Ischaemic heart disease remains a major cause of disability and death world-wide. When a\nmajor blood vessel in the heart suddenly becomes blocked, the muscle that it supplies dies\nand is replaced with scar tissue. This is what happens in a heart attack. The scarred heart\nno longer pumps blood properly and 40% of patients who develop heart failure die within 5\nyears. There is currently no treatment to help make new heart muscle after a heart attack.\nWe have identified a protein already present in the body, a single injection of which within a\nfew hours after injury can dramatically improve heart function by limiting damage and\npromoting repair. We will now engineer this protein molecule to retain only the regenerative\nproperties, whilst eliminating potential unwanted effects. We anticipate the engineered\nproduct to be safe, limit the damage after a heart attack and also promote regeneration of\nheart muscle.","plannedDates":[{"endDate":"2022-12-31T00:00:00+00:00","startDate":"2021-01-01T00:00:00+00:00","startDateDateOnly":"2021-01-01","endDateDateOnly":"2022-12-31"}],"amountAwarded":504745,"Financial Year":"2019/20","Lead Applicant":"Prof Jagdeep Nanchahal","grantProgramme":[{"title":"Innovator Award","title_keyword":"Innovator Award"}],"Applicant Surname":"Nanchahal","Partnership Value":504745,"Approval Committee":"Innovator Awards Advisory Group","Other Applicant(s)":"Dr Wyatt Yue, Prof Chas Bountra, Dr Nicola Burgess-Brown, Prof Robin Choudhury, Prof Sir Marc Feldmann, Prof Paul Riley, Prof Carolyn Carr","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"\u2018Harnessing endogenous mechanisms to promote cardiac regeneration\u2019 Ischaemic heart disease remains a major cause of disability and death world-wide. When a\nmajor blood vessel in the heart suddenly becomes blocked, the muscle that it supplies dies\nand is replaced with scar tissue. This is what happens in a heart attack. The scarred heart\nno longer pumps blood properly and 40% of patients who develop heart failure die within 5\nyears. There is currently no treatment to help make new heart muscle after a heart attack.\nWe have identified a protein already present in the body, a single injection of which within a\nfew hours after injury can dramatically improve heart function by limiting damage and\npromoting repair. We will now engineer this protein molecule to retain only the regenerative\nproperties, whilst eliminating potential unwanted effects. We anticipate the engineered\nproduct to be safe, limit the damage after a heart attack and also promote regeneration of\nheart muscle.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-221571_Z_20_Z","title":"POETIC-COVID \u2013 Providing Essential Treatment in Critical Illness for COVID-19","Region":"Greater London","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221571/Z/20/Z","description":"As COVID-19 lacks a definitive treatment, critical care is the primary therapeutic means for\nreducing mortality. How the world effectively scales up critical care will be a fundamental\ndeterminant of the overall impact of the pandemic. Advanced critical care may be difficult or\nimpossible to scale-up in many settings and instead, essential, life-saving treatments should\nbe provided to all who need. Essential Emergency and Critical Care (EECC) is the basic,\nlow-cost care required by critically ill patients, such as oxygen and intravenous fluids, and\nthe system-wide requirements for their provision. The project will assess the costeffectiveness\nof EECC and advanced critical care in Tanzania and Kenya, and analyse the\nimpact of the global and national response strategies to COVID-19 on critical care services.\nThe project aims to guide COVID-19 responses in LMICs towards scalable strategies with\nthe greatest potential for increased survival of critically ill patients, both in the pandemic and\nbeyond.","plannedDates":[{"endDate":"2021-12-31T00:00:00+00:00","startDate":"2020-09-01T00:00:00+00:00","startDateDateOnly":"2020-09-01","endDateDateOnly":"2021-12-31"}],"amountAwarded":498656,"Financial Year":"2019/20","Lead Applicant":"Dr Tim Baker","grantProgramme":[{"title":"Discretionary Award \u2013 Innovations","title_keyword":"Discretionary Award \u2013 Innovations"}],"Applicant Surname":"Baker","Partnership Value":498656,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-and-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine","addressCountry":"United Kingdom","id_and_name":"[\"London School of Hygiene & Tropical Medicine\", \"360G-Wellcome-ORG:London-School-of-Hygiene-and-Tropical-Medicine\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:London-School-of-Hygiene-and-Tropical-Medicine","name":"London School of Hygiene & Tropical Medicine"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"POETIC-COVID \u2013 Providing Essential Treatment in Critical Illness for COVID-19 As COVID-19 lacks a definitive treatment, critical care is the primary therapeutic means for\nreducing mortality. How the world effectively scales up critical care will be a fundamental\ndeterminant of the overall impact of the pandemic. Advanced critical care may be difficult or\nimpossible to scale-up in many settings and instead, essential, life-saving treatments should\nbe provided to all who need. Essential Emergency and Critical Care (EECC) is the basic,\nlow-cost care required by critically ill patients, such as oxygen and intravenous fluids, and\nthe system-wide requirements for their provision. The project will assess the costeffectiveness\nof EECC and advanced critical care in Tanzania and Kenya, and analyse the\nimpact of the global and national response strategies to COVID-19 on critical care services.\nThe project aims to guide COVID-19 responses in LMICs towards scalable strategies with\nthe greatest potential for increased survival of critically ill patients, both in the pandemic and\nbeyond.","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-221570_Z_20_Z","title":"Responsive Dialogues to Improve Public Engagement on AMR","Region":"North West","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"221570/Z/20/Z","description":"The diminishing effectiveness of antimicrobials is a public health challenge of major global importance. In the Global South, where health systems are weaker and the burden of severe bacterial infection greater, the impact is already being acutely felt. In Malawi, a Ministerial AMR Unit has been established to coordinate Malawi\u2019s response, culminating in a National Action Plan. However, the implementation of the Action Plan needs key stakeholders \u2013 including affected community members \u2013 to develop and implement interventions. This project will undertake facilitated dialogues with stakeholders in two different contexts: rural Chikwawa and urban Blantyre. Through four Responsive Dialogues events per area, participants from national, district and community levels will share their understandings, experiences and perspectives on AMR, leading to the co-creation of concrete policy asks and actions. Conversations will be carefully designed and facilitated to enable evidence about AMR to be shared, understood and used to generate ideas, as well as to inform policies governing how AMR is addressed. Through this approach the project will work closely with the AMR unit to cocreate local actions, that communities themselves can carry out to reduce the burden of AMR as well as policies and interventions that reflect people\u2019s lived realities. \n","plannedDates":[{"endDate":"2022-09-30T00:00:00+00:00","startDate":"2020-10-01T00:00:00+00:00","startDateDateOnly":"2020-10-01","endDateDateOnly":"2022-09-30"}],"amountAwarded":248385,"Financial Year":"2019/20","Lead Applicant":"Dr Eleanor MacPherson","grantProgramme":[{"title":"Discretionary Award - Public Engagement","title_keyword":"Discretionary Award - Public Engagement"}],"Applicant Surname":"MacPherson","Partnership Value":248385,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Liverpool-School-of-Tropical-Medicine","name":"Liverpool School of Tropical Medicine","addressCountry":"United Kingdom","id_and_name":"[\"Liverpool School of Tropical Medicine\", \"360G-Wellcome-ORG:Liverpool-School-of-Tropical-Medicine\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Liverpool-School-of-Tropical-Medicine","name":"Liverpool School of Tropical Medicine"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Responsive Dialogues to Improve Public Engagement on AMR The diminishing effectiveness of antimicrobials is a public health challenge of major global importance. In the Global South, where health systems are weaker and the burden of severe bacterial infection greater, the impact is already being acutely felt. In Malawi, a Ministerial AMR Unit has been established to coordinate Malawi\u2019s response, culminating in a National Action Plan. However, the implementation of the Action Plan needs key stakeholders \u2013 including affected community members \u2013 to develop and implement interventions. This project will undertake facilitated dialogues with stakeholders in two different contexts: rural Chikwawa and urban Blantyre. Through four Responsive Dialogues events per area, participants from national, district and community levels will share their understandings, experiences and perspectives on AMR, leading to the co-creation of concrete policy asks and actions. Conversations will be carefully designed and facilitated to enable evidence about AMR to be shared, understood and used to generate ideas, as well as to inform policies governing how AMR is addressed. Through this approach the project will work closely with the AMR unit to cocreate local actions, that communities themselves can carry out to reduce the burden of AMR as well as policies and interventions that reflect people\u2019s lived realities. \n","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-224028_Z_21_Z","title":"Economic analysis of health impacts of carbon pricing on land-use ","Region":"East of England","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"224028/Z/21/Z","description":"The proposed work is \u2013 to our knowledge - the first integrated economic analysis of a single policy intervention and its potential to influence three interlinked threats: the global health crises of both non-communicable diseases and new infectious diseases such as Covid-19, as well as environmental degradation, including biodiversity loss and climate change.\n\nThe work will comprise modelling the consequences of carbon pricing, set at a level compatible with keeping climate change within planetary boundaries, with outcomes including land-system change, agricultural production, food prices, diets and health outcomes, and effects on infectious disease and biodiversity. The analysis will consider potential differential effects of carbon pricing across socio-economic groups, and between high, medium and low-income countries, as a basis for considering policy interventions to mitigate inequitable outcomes.\n\nThis analysis will contribute to the goal of The Lancet-Chatham House Commission which is to identify actions that can impact positively across the shared drivers of the three threats to human and planetary health described above. Importantly it will provide novel evidence for the ways in which co-benefits and\nco-costs of interventions might form a significant part of the political and economic cases for intervening at national and international levels and optimising policy design.\n","plannedDates":[{"endDate":"2021-12-27T00:00:00+00:00","startDate":"2021-06-28T00:00:00+00:00","startDateDateOnly":"2021-06-28","endDateDateOnly":"2021-12-27"}],"amountAwarded":50000,"Financial Year":"2020/21","Lead Applicant":"Prof Dame Theresa Marteau","grantProgramme":[{"title":"Discretionary Award - OPOH","title_keyword":"Discretionary Award - OPOH"}],"Applicant Surname":"Marteau","Partnership Value":50000,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Cambridge","name":"University of Cambridge","addressCountry":"United Kingdom","id_and_name":"[\"University of Cambridge\", \"360G-Wellcome-ORG:University-of-Cambridge\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Cambridge","name":"University of Cambridge"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Economic analysis of health impacts of carbon pricing on land-use The proposed work is \u2013 to our knowledge - the first integrated economic analysis of a single policy intervention and its potential to influence three interlinked threats: the global health crises of both non-communicable diseases and new infectious diseases such as Covid-19, as well as environmental degradation, including biodiversity loss and climate change.\n\nThe work will comprise modelling the consequences of carbon pricing, set at a level compatible with keeping climate change within planetary boundaries, with outcomes including land-system change, agricultural production, food prices, diets and health outcomes, and effects on infectious disease and biodiversity. The analysis will consider potential differential effects of carbon pricing across socio-economic groups, and between high, medium and low-income countries, as a basis for considering policy interventions to mitigate inequitable outcomes.\n\nThis analysis will contribute to the goal of The Lancet-Chatham House Commission which is to identify actions that can impact positively across the shared drivers of the three threats to human and planetary health described above. Importantly it will provide novel evidence for the ways in which co-benefits and\nco-costs of interventions might form a significant part of the political and economic cases for intervening at national and international levels and optimising policy design.\n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-224017_Z_21_Z","title":"Topic Level bite-sized CPD in Science","Region":"East of England","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"224017/Z/21/Z","description":"The purpose of the project is to test the impact and value of delivering subject-specific CPD in upper primary, lower secondary science through \u2018bite-sized\u2019 online courses linked to micro-accreditation. It will:\n\n\n develop three online CPD units focusing on teaching more challenging ideas in science to pupils at upper primary and lower secondary level (ages 9-13)\n test \u2018proof of principle\u2019 that a structured online CPD course comprising \u2018bite-sized\u2019 CPD units supports teachers of primary and lower secondary science in strengthening their subject knowledge (SK) and their pedagogic content knowledge (PCK); and indirectly improves pupils\u2019 understanding of difficult ideas in science;\n enable teachers using the CPD resources to gain micro-accreditation in those topics, recognising and certifying their skills and knowledge, and explore ways to promote the value of this accreditation to senior leadership and more widely, including as evidence towards other accreditations such as Chartered Science Teacher (CSciTeach);\n test the \u2018buy-in\u2019 to the value of micro-accreditation by senior leadership in building up a pool of teachers who are skilled, confident (and ultimately deployed) to teach age and stage appropriate topics of the science curriculum; and as a tool to inform individual professional learning needs, promotion; and support targeted recruitment and retention strategies.\n\n\n \n","plannedDates":[{"endDate":"2023-02-15T00:00:00+00:00","startDate":"2021-08-16T00:00:00+00:00","startDateDateOnly":"2021-08-16","endDateDateOnly":"2023-02-15"}],"amountAwarded":128102,"Financial Year":"2020/21","Lead Applicant":"Ms Marianne E Cutler","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"E Cutler","Partnership Value":128102,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Prof Judith Bennett","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:The-Association-for-Science-Education","name":"The Association for Science Education","addressCountry":"United Kingdom","id_and_name":"[\"The Association for Science Education\", \"360G-Wellcome-ORG:The-Association-for-Science-Education\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:The-Association-for-Science-Education","name":"The Association for Science Education"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Topic Level bite-sized CPD in Science The purpose of the project is to test the impact and value of delivering subject-specific CPD in upper primary, lower secondary science through \u2018bite-sized\u2019 online courses linked to micro-accreditation. It will:\n\n\n develop three online CPD units focusing on teaching more challenging ideas in science to pupils at upper primary and lower secondary level (ages 9-13)\n test \u2018proof of principle\u2019 that a structured online CPD course comprising \u2018bite-sized\u2019 CPD units supports teachers of primary and lower secondary science in strengthening their subject knowledge (SK) and their pedagogic content knowledge (PCK); and indirectly improves pupils\u2019 understanding of difficult ideas in science;\n enable teachers using the CPD resources to gain micro-accreditation in those topics, recognising and certifying their skills and knowledge, and explore ways to promote the value of this accreditation to senior leadership and more widely, including as evidence towards other accreditations such as Chartered Science Teacher (CSciTeach);\n test the \u2018buy-in\u2019 to the value of micro-accreditation by senior leadership in building up a pool of teachers who are skilled, confident (and ultimately deployed) to teach age and stage appropriate topics of the science curriculum; and as a tool to inform individual professional learning needs, promotion; and support targeted recruitment and retention strategies.\n\n\n \n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-224016_Z_21_Z","title":"Making change happen in teacher professional development","Region":"Yorkshire and the Humber","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"224016/Z/21/Z","description":"There is a strong evidence base on effective continuing professional development (CPD) for teachers, but in spite of this evidence, there has been limited sustained change towards the goal of all teachers being able to participate in high quality professional development throughout their careers. To address this, greater understanding is needed of how to make change happen: the implementation of innovations and programmes in relation to policy and entitlements and the school environment; and the mechanisms and processes which underpin change.\nApplying insights from implementation science and theory-based evaluation, our proposed research will identify a series of \u2018mechanisms for change\u2019 applicable to teacher CPD policy and practice in school environments in England, to guide CPD practice by schools and policy-makers. Four complementary project strands (a systematic evidence review; STEM CPD policy analysis; investigating effective change implementation in CPD, through mixed methods of survey and case studies; stakeholder engagement and dissemination) will lead to evidence-based guidance for effective implementation of CPD in England at multiple system levels, whether a local system (e.g. a single department or school CPD), larger system (e.g. programmes for a specific teacher subject group or phase) or the whole education system (e.g. increasing access to CPD). \n","plannedDates":[{"endDate":"2023-02-28T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00","startDateDateOnly":"2021-09-01","endDateDateOnly":"2023-02-28"}],"amountAwarded":153054,"Financial Year":"2020/21","Lead Applicant":"Prof Emily Perry","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"Perry","Partnership Value":153054,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Sheffield-Hallam-University","name":"Sheffield Hallam University","addressCountry":"United Kingdom","id_and_name":"[\"Sheffield Hallam University\", \"360G-Wellcome-ORG:Sheffield-Hallam-University\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Sheffield-Hallam-University","name":"Sheffield Hallam University"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Making change happen in teacher professional development There is a strong evidence base on effective continuing professional development (CPD) for teachers, but in spite of this evidence, there has been limited sustained change towards the goal of all teachers being able to participate in high quality professional development throughout their careers. To address this, greater understanding is needed of how to make change happen: the implementation of innovations and programmes in relation to policy and entitlements and the school environment; and the mechanisms and processes which underpin change.\nApplying insights from implementation science and theory-based evaluation, our proposed research will identify a series of \u2018mechanisms for change\u2019 applicable to teacher CPD policy and practice in school environments in England, to guide CPD practice by schools and policy-makers. Four complementary project strands (a systematic evidence review; STEM CPD policy analysis; investigating effective change implementation in CPD, through mixed methods of survey and case studies; stakeholder engagement and dissemination) will lead to evidence-based guidance for effective implementation of CPD in England at multiple system levels, whether a local system (e.g. a single department or school CPD), larger system (e.g. programmes for a specific teacher subject group or phase) or the whole education system (e.g. increasing access to CPD). \n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-224009_Z_21_Z","title":"Mindscapes Curatorial Research Fellow","Region":"International","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"224009/Z/21/Z","description":"Mindscapes Curatorial Research Fellow\nFull-time position with CARMAH, reporting to the Director\n\nThis post-doctoral fellowship appointment will assist with the research and development phase of a new project looking at aspects of mental health with a specific focus on Berlin. Alongside pursuing self-directed research, the fellow will work closely with members of Wellcome\u2019s International Cultural Programmes team and Wellcome\u2019s Germany Office under the direction of the International Cultural Producer Danielle Olsen to: \n\n- Develop external partnerships across the city with partner organisations on the theme of mental health in Berlin investigating potential archives, collections, institutions and community led organisations that could provide a focus for transdisciplinary research\n\n- Serve as connector across participant spaces and places, developing creative new links with international city partners (in Bengaluru, New York and Tokyo) as the project develops\n\n- Assist in developing interdisciplinary and inclusive methods and processes between and across the Arts and Sciences on a mental health theme\n\n- Participate in a launch meeting in July 2021 on a mental health theme with a Berlin City focus\n\n- Explore crossover and hybrid experimental curatorial possibilities utilizing original creative work, events, and public programming.\n \n","plannedDates":[{"endDate":"2023-06-30T00:00:00+00:00","startDate":"2021-07-01T00:00:00+00:00","startDateDateOnly":"2021-07-01","endDateDateOnly":"2023-06-30"}],"amountAwarded":137623,"Financial Year":"2020/21","Lead Applicant":"Prof Sharon Macdonald","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"Macdonald","Partnership Value":137623,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Humboldt-University-of-Berlin","name":"Humboldt University of Berlin","addressCountry":"Germany","id_and_name":"[\"Humboldt University of Berlin\", \"360G-Wellcome-ORG:Humboldt-University-of-Berlin\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Humboldt-University-of-Berlin","name":"Humboldt University of Berlin"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Mindscapes Curatorial Research Fellow Mindscapes Curatorial Research Fellow\nFull-time position with CARMAH, reporting to the Director\n\nThis post-doctoral fellowship appointment will assist with the research and development phase of a new project looking at aspects of mental health with a specific focus on Berlin. Alongside pursuing self-directed research, the fellow will work closely with members of Wellcome\u2019s International Cultural Programmes team and Wellcome\u2019s Germany Office under the direction of the International Cultural Producer Danielle Olsen to: \n\n- Develop external partnerships across the city with partner organisations on the theme of mental health in Berlin investigating potential archives, collections, institutions and community led organisations that could provide a focus for transdisciplinary research\n\n- Serve as connector across participant spaces and places, developing creative new links with international city partners (in Bengaluru, New York and Tokyo) as the project develops\n\n- Assist in developing interdisciplinary and inclusive methods and processes between and across the Arts and Sciences on a mental health theme\n\n- Participate in a launch meeting in July 2021 on a mental health theme with a Berlin City focus\n\n- Explore crossover and hybrid experimental curatorial possibilities utilizing original creative work, events, and public programming.\n \n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-224008_Z_21_Z","title":"Equity and quality in local learning systems (EQuaLLS)","Region":"East Midlands","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"224008/Z/21/Z","description":"Schooling in England is complex and evolving. Large-scale academisation has fragmented local landscapes and created multiple models for knowledge exchange, increasing the risk that continuing professional development (CPD) for teachers becomes variable in terms of quality, equity of access, and impact. More recently, national CPD frameworks have been made more coherent, while local areas are being encouraged to coordinate CPD offers through new Teaching School Hubs.\n\nUnderstanding how this systemic process of fragmentation and re-formation is impacting on CPD for schools and teachers is a pressing concern. The EQuaLLS project will focus on \u2018local learning systems\u2019 (LLS): place-based localities encompassing a mix of school structures and hub arrangements for teacher CPD.\n\nUsing primary mathematics as a case study, we will research 'to what extent, and how, do LLS operate to provide high quality, inclusive professional learning for schools?' In four phases, we will: i) harness existing knowledge; ii) identify three representative localities and 18 schools for study; iii) investigate equity and quality of primary mathematics CPD; and iv) analyse findings, identify implications and disseminate these widely.\n\nThe findings will inform policy and practice, helping school and system leaders to shape and navigate high quality, inclusive and effective local CPD systems.\n","plannedDates":[{"endDate":"2022-12-31T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00","startDateDateOnly":"2021-09-01","endDateDateOnly":"2022-12-31"}],"amountAwarded":132988,"Financial Year":"2020/21","Lead Applicant":"Prof Toby Greany","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"Greany","Partnership Value":132988,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Nottingham","name":"University of Nottingham","addressCountry":"United Kingdom","id_and_name":"[\"University of Nottingham\", \"360G-Wellcome-ORG:University-of-Nottingham\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Nottingham","name":"University of Nottingham"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Equity and quality in local learning systems (EQuaLLS) Schooling in England is complex and evolving. Large-scale academisation has fragmented local landscapes and created multiple models for knowledge exchange, increasing the risk that continuing professional development (CPD) for teachers becomes variable in terms of quality, equity of access, and impact. More recently, national CPD frameworks have been made more coherent, while local areas are being encouraged to coordinate CPD offers through new Teaching School Hubs.\n\nUnderstanding how this systemic process of fragmentation and re-formation is impacting on CPD for schools and teachers is a pressing concern. The EQuaLLS project will focus on \u2018local learning systems\u2019 (LLS): place-based localities encompassing a mix of school structures and hub arrangements for teacher CPD.\n\nUsing primary mathematics as a case study, we will research 'to what extent, and how, do LLS operate to provide high quality, inclusive professional learning for schools?' In four phases, we will: i) harness existing knowledge; ii) identify three representative localities and 18 schools for study; iii) investigate equity and quality of primary mathematics CPD; and iv) analyse findings, identify implications and disseminate these widely.\n\nThe findings will inform policy and practice, helping school and system leaders to shape and navigate high quality, inclusive and effective local CPD systems.\n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223888_Z_21_Z","title":"Generating collective solutions to reduce unnecessary antibiotic use in Vietnam","Region":"South East","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"223888/Z/21/Z","description":"Antibiotic resistance in Vietnam is amongst the highest in the world, driven by high levels of antibiotic use for human and animal health. Community understanding and perceptions about antibiotics and antibiotic resistance is poor, and antibiotics are often prescribed inappropriately in healthcare settings. There is limited evidence for the effectiveness of public engagement approaches to promote appropriate antibiotic use, compared to more traditional education-based methods, or for understanding the pathways and facilitating conditions for successful behaviour change.\n\nWe will facilitate community-wide change in the way people prescribe and use antibiotics for human and animal health. We will compare three different One Health approaches to change behaviour: training for human and animal health-workers; a public information campaign for communities and farmers; and participatory action research groups. Activators in communities and healthcare settings will guide groups through a four-phase action cycle similar to Wellcome\u2019s Responsive Dialogues approach, covering: 1. Understanding the problem of antibiotic resistance; 2. Planning and implementing strategies; 3. Monitoring strategies and generating evidence; 4. Evaluating strategies and planning future actions. We will evaluate the impact on knowledge and behaviour through qualitative and quantitative methods. We will engage local researchers and policymakers through formative discussions and dissemination meetings.\n","plannedDates":[{"endDate":"2023-06-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00","startDateDateOnly":"2021-10-01","endDateDateOnly":"2023-06-30"}],"amountAwarded":140158,"Financial Year":"2020/21","Lead Applicant":"Dr Sonia Lewycka","grantProgramme":[{"title":"Discretionary Award - Public Engagement","title_keyword":"Discretionary Award - Public Engagement"}],"Applicant Surname":"Lewycka","Partnership Value":140158,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Generating collective solutions to reduce unnecessary antibiotic use in Vietnam Antibiotic resistance in Vietnam is amongst the highest in the world, driven by high levels of antibiotic use for human and animal health. Community understanding and perceptions about antibiotics and antibiotic resistance is poor, and antibiotics are often prescribed inappropriately in healthcare settings. There is limited evidence for the effectiveness of public engagement approaches to promote appropriate antibiotic use, compared to more traditional education-based methods, or for understanding the pathways and facilitating conditions for successful behaviour change.\n\nWe will facilitate community-wide change in the way people prescribe and use antibiotics for human and animal health. We will compare three different One Health approaches to change behaviour: training for human and animal health-workers; a public information campaign for communities and farmers; and participatory action research groups. Activators in communities and healthcare settings will guide groups through a four-phase action cycle similar to Wellcome\u2019s Responsive Dialogues approach, covering: 1. Understanding the problem of antibiotic resistance; 2. Planning and implementing strategies; 3. Monitoring strategies and generating evidence; 4. Evaluating strategies and planning future actions. We will evaluate the impact on knowledge and behaviour through qualitative and quantitative methods. We will engage local researchers and policymakers through formative discussions and dissemination meetings.\n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223801_Z_21_A","title":"Neuromatch Summer Academy","Region":"International","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223801/Z/21/A","description":"Not available","plannedDates":[{"endDate":"2021-08-05T00:00:00+00:00","startDate":"2021-07-05T00:00:00+00:00","startDateDateOnly":"2021-07-05","endDateDateOnly":"2021-08-05"}],"amountAwarded":20000,"Financial Year":"2020/21","Lead Applicant":"Dr G. 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By making these people our co-directors and enabling viewers to experience the world through them, they will offer a sense of connection to the crisis that is unfiltered, intimate and immediate \u2013 strikingly different from typical climate crisis documentaries. \n\nThe films will marry stories from the frontlines with stories that offer hope and offer a constructive way forward. Critically, they will also bring attention, insight and understanding to the relationship between health and climate, in alignment with Wellcome\u2019s strategic objectives. \n\nThe feature documentary\u2019s large-scale, multi-pronged impact campaign will target global and national decision-makers, key stakeholders and the public (including specific target communities). 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The project will connect a wider audience of museum visitors to these stories through accessible written content as well as the Museum\u2019s public engagement programmes, encouraging understanding of and reflection on a shared history of domestic health.\n","awardDateDateOnly":"2021-06-18","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223690_Z_21_Z","title":"The New Jerusalems: post-war New Town archives in Britain and Ireland","Region":"South East","currency":"GBP","awardDate":"2021-05-20T00:00:00+00:00","Internal ID":"223690/Z/21/Z","description":"The project will make accessible for research eleven archives from post-war new towns in England, Wales and Ireland. Eight of these archives will be catalogued and all will be safeguarded through conservation and preservation work. The new towns included are: Basildon, Bracknell, Crawley, Cwmbran, Newton Aycliffe, Peterlee, Redditch, Runcorn, Shannon, Stevenage and Warrington.\n\nThe archives are held by nine partner organisations brought together through the Association of New Towns Archives and Museums. The Association builds on existing academic partnerships, and this project will develop those further. Key outcomes include not only itemised catalogues and protected collections, but also a collaborative dissemination programme.\n\nThis project will provide a substantial increase in the evidence base available for researchers seeking to interrogate the new towns\u2019 legacy. The project is particularly timely in the context of the current public health emergency. New towns have much to contribute to current policy making in urban planning and public health including: new homes to reduce overcrowding; generous public green space; amenities within 15 minutes of the home; and supporting walking and cycling. There is renewed interest in many aspects of new town design as plans are made for social recovery in the aftermath of Covid-19. \n \n","plannedDates":[{"endDate":"2025-10-31T00:00:00+00:00","startDate":"2021-11-01T00:00:00+00:00","startDateDateOnly":"2021-11-01","endDateDateOnly":"2025-10-31"}],"amountAwarded":427809,"Financial Year":"2020/21","Lead Applicant":"Mrs Wendy Walker","grantProgramme":[{"title":"Research Resources Award","title_keyword":"Research Resources Award"}],"Applicant Surname":"Walker","Partnership Value":427809,"Approval Committee":"Research Resources Committee","Other Applicant(s)":"Dr Kirsten Mulrennan, Mr Mark Stevens, Ms Liz Bregazzi, Mr Christopher Bennett, Mr Richard Anderson, Dr Lisa Snook, Ms Claire Haslam, Ms Lisa Greenhalgh","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:West-Sussex-County-Council","name":"West Sussex County Council","addressCountry":"United Kingdom","id_and_name":"[\"West Sussex County Council\", \"360G-Wellcome-ORG:West-Sussex-County-Council\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:West-Sussex-County-Council","name":"West Sussex County Council"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"The New Jerusalems: post-war New Town archives in Britain and Ireland The project will make accessible for research eleven archives from post-war new towns in England, Wales and Ireland. Eight of these archives will be catalogued and all will be safeguarded through conservation and preservation work. The new towns included are: Basildon, Bracknell, Crawley, Cwmbran, Newton Aycliffe, Peterlee, Redditch, Runcorn, Shannon, Stevenage and Warrington.\n\nThe archives are held by nine partner organisations brought together through the Association of New Towns Archives and Museums. The Association builds on existing academic partnerships, and this project will develop those further. Key outcomes include not only itemised catalogues and protected collections, but also a collaborative dissemination programme.\n\nThis project will provide a substantial increase in the evidence base available for researchers seeking to interrogate the new towns\u2019 legacy. The project is particularly timely in the context of the current public health emergency. New towns have much to contribute to current policy making in urban planning and public health including: new homes to reduce overcrowding; generous public green space; amenities within 15 minutes of the home; and supporting walking and cycling. There is renewed interest in many aspects of new town design as plans are made for social recovery in the aftermath of Covid-19. \n \n","awardDateDateOnly":"2021-05-20","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223679_Z_21_Z","title":"Mass-Observing Covid-19","Region":"South East","currency":"GBP","awardDate":"2021-05-20T00:00:00+00:00","Internal ID":"223679/Z/21/Z","description":"Mass-Observation (M-O) has been recording everyday life in Britain since 1937. Since the start of the Covid-19 crisis, we have collected over 8500 pieces of narrative life writing, ranging in format from open-questionnaire responses and day diaries to diaries kept for several months by self-selecting volunteers of all ages from around the UK. This unique set of large-scale qualitative data offers extensive research value and potential to contextualise quantitative data generated throughout the pandemic. \n\nThis project will open up the extensive collections of qualitative data relating to the impact of Covid-19 on the mental and physical health and social welfare of volunteer writers around the UK. We will build a tool for discovery and exploration that allows researchers to interrogate these collections. \n\nA database will comprise metadata on the writers and writing that enables researchers across disciplines to interrogate the content of the data, thereby contributing to our understanding of the social and personal impact on UK health and wellbeing during the Covid-19 pandemic. The tool is designed to open up access to the texts that have been submitted, allowing researchers to select relevant materials and export the data into their own choice of research tools for analysis. \n","plannedDates":[{"endDate":"2023-04-30T00:00:00+00:00","startDate":"2021-11-01T00:00:00+00:00","startDateDateOnly":"2021-11-01","endDateDateOnly":"2023-04-30"}],"amountAwarded":180137,"Financial Year":"2020/21","Lead Applicant":"Dr Fiona Courage","grantProgramme":[{"title":"Research Resources Award","title_keyword":"Research Resources Award"}],"Applicant Surname":"Courage","Partnership Value":180137,"Approval Committee":"Research Resources Committee","Other Applicant(s)":"Ms Kirsty Pattrick","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Sussex","name":"University of Sussex","addressCountry":"United Kingdom","id_and_name":"[\"University of Sussex\", \"360G-Wellcome-ORG:University-of-Sussex\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Sussex","name":"University of Sussex"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Mass-Observing Covid-19 Mass-Observation (M-O) has been recording everyday life in Britain since 1937. Since the start of the Covid-19 crisis, we have collected over 8500 pieces of narrative life writing, ranging in format from open-questionnaire responses and day diaries to diaries kept for several months by self-selecting volunteers of all ages from around the UK. This unique set of large-scale qualitative data offers extensive research value and potential to contextualise quantitative data generated throughout the pandemic. \n\nThis project will open up the extensive collections of qualitative data relating to the impact of Covid-19 on the mental and physical health and social welfare of volunteer writers around the UK. We will build a tool for discovery and exploration that allows researchers to interrogate these collections. \n\nA database will comprise metadata on the writers and writing that enables researchers across disciplines to interrogate the content of the data, thereby contributing to our understanding of the social and personal impact on UK health and wellbeing during the Covid-19 pandemic. The tool is designed to open up access to the texts that have been submitted, allowing researchers to select relevant materials and export the data into their own choice of research tools for analysis. \n","awardDateDateOnly":"2021-05-20","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223678_Z_21_Z","title":"Incorporating the Social Dimension of Pollution and Health into UNEP's Programmes and Mid-Term Strategy","Region":"South East","currency":"GBP","awardDate":"2021-06-18T00:00:00+00:00","Internal ID":"223678/Z/21/Z","description":"Through a collaboration with the United Nations Environment Programme (UNEP), this 6-month secondment will bring insights from the fields of environmental justice, medical anthropology, and health geography into UNEP\u2019s implementation plan \"Toward a Pollution Free Planet\". The point of departure for this collaboration is premised on an understanding of pollution as embedded in wider processes of industrialisation that causes social fragmentation and a diffused disempowerment of the communities it affects. As this represents an underexplored area of work in international policymaking, this secondment will focus on understanding and proposing implementation pathways that can lead to increased participation of communities in initiatives to curb pollution.\n\nThe outputs produced through this secondment will be integrated within UNEP\u2019s Pollution and Health unit's work on integrated methodologies and tools. The first half of the secondment will be spent conducting a literature review on pollution and community action in the form of a report. The report will focus on identifying the factors that promote and hinder community participation, resilience, and agency. The second half of the secondment will be spent to produce an indicators framework to be utilized to assess the effectiveness of UNEP\u2019s implementation plan in engaging the public and fostering participation and resilience. \n","plannedDates":[{"endDate":"2022-06-30T00:00:00+00:00","startDate":"2022-01-01T00:00:00+00:00","startDateDateOnly":"2022-01-01","endDateDateOnly":"2022-06-30"}],"amountAwarded":14328,"Financial Year":"2020/21","Lead Applicant":"Mr Angelo Raffaele Ippolito","grantProgramme":[{"title":"WT/POST Fellowship","title_keyword":"WT/POST Fellowship"}],"Applicant Surname":"Ippolito","Partnership Value":14328,"Approval Committee":"Secondment Fellowship Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Incorporating the Social Dimension of Pollution and Health into UNEP's Programmes and Mid-Term Strategy Through a collaboration with the United Nations Environment Programme (UNEP), this 6-month secondment will bring insights from the fields of environmental justice, medical anthropology, and health geography into UNEP\u2019s implementation plan \"Toward a Pollution Free Planet\". The point of departure for this collaboration is premised on an understanding of pollution as embedded in wider processes of industrialisation that causes social fragmentation and a diffused disempowerment of the communities it affects. As this represents an underexplored area of work in international policymaking, this secondment will focus on understanding and proposing implementation pathways that can lead to increased participation of communities in initiatives to curb pollution.\n\nThe outputs produced through this secondment will be integrated within UNEP\u2019s Pollution and Health unit's work on integrated methodologies and tools. The first half of the secondment will be spent conducting a literature review on pollution and community action in the form of a report. The report will focus on identifying the factors that promote and hinder community participation, resilience, and agency. The second half of the secondment will be spent to produce an indicators framework to be utilized to assess the effectiveness of UNEP\u2019s implementation plan in engaging the public and fostering participation and resilience. \n","awardDateDateOnly":"2021-06-18","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 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story of changing online health information be captured and understood?\n\nDuring the Covid-19 pandemic, online health advice, data and scientific evidence have been contested, revised, used and mis-used with global consequences \u2013 but the digital record of this activity is fragile and hard to access.\n\nWe will:\n\n\n Curate a new research-ready collection of websites within the UKWA, with the theme of Health Information and Misinformation, ensuring a wide representation of diverse and otherwise under-collected sources.\n Use this collection as a test-bed to explore options for metadata, computational analysis, ethics and rights issues.\n Build a research network across disciplines including use cases, involving researchers in the process of building, evaluating and using collections.\n Produce a project report with recommendations for future work and advocacy for change to make web archives more representative, inclusive and open for health research.\n\n","awardDateDateOnly":"2021-05-20","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 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This is an essential national and international resource for exploring intersections between feminist activism, creative practice, and public health information.\n\nThe project will:\n\n\n Secure the archive in a publicly accessible repository, appraised, organised and repackaged to archival standards.\n Create an online catalogue with detailed index points to enable network mapping and exploration.\n Showcase interdisciplinary research opportunities, and create new research networks through the University of Leeds and beyond.\n Embed the archive in research led teaching and lifelong learning, including online delivery.\n\n","plannedDates":[{"endDate":"2024-05-09T00:00:00+00:00","startDate":"2022-01-10T00:00:00+00:00","startDateDateOnly":"2022-01-10","endDateDateOnly":"2024-05-09"}],"amountAwarded":113611,"Financial Year":"2020/21","Lead Applicant":"Ms Joanne Fitton","grantProgramme":[{"title":"Research Resources Award","title_keyword":"Research Resources Award"}],"Applicant Surname":"Fitton","Partnership Value":113611,"Approval Committee":"Research Resources Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Leeds","name":"University of Leeds","addressCountry":"United Kingdom","id_and_name":"[\"University of Leeds\", \"360G-Wellcome-ORG:University-of-Leeds\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Leeds","name":"University of Leeds"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Public Health Animation in Leeds Leeds Animation Workshop (LAW) is a not-for-profit cooperative company established in 1978 and run by women. It produces and distributes animated films on social, health and educational issues, with international distribution. Subjects include childcare, violence against women, bereavement, child protection, parenting and relationships, gender and equal opportunities, bullying and homelessness. LAW has created films for audiences with learning difficulties and provides training in basic animation for adults and young people.\n\nThe LAW archive is a unique survival. It is the only complete archive of a collective independent filmmaking organisation. The archive is key to understanding the production of public information films and provides a counterpoint to \u2018establishment\u2019 films of the period. This is an essential national and international resource for exploring intersections between feminist activism, creative practice, and public health information.\n\nThe project will:\n\n\n Secure the archive in a publicly accessible repository, appraised, organised and repackaged to archival standards.\n Create an online catalogue with detailed index points to enable network mapping and exploration.\n Showcase interdisciplinary research opportunities, and create new research networks through the University of Leeds and beyond.\n Embed the archive in research led teaching and lifelong learning, including online delivery.\n\n","awardDateDateOnly":"2021-05-20","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223661_Z_21_Z","title":"Curious cures: enhancing the discoverability of medieval medical recipes","Region":"East of England","currency":"GBP","awardDate":"2021-05-20T00:00:00+00:00","Internal ID":"223661/Z/21/Z","description":"This two-year, collaborative project will open up to health researchers worldwide 187 medieval manuscripts containing medical recipes across Cambridge collections, and the currently inaccessible corpus of approximately 8000 Latin and Middle English medical recipes that they contain.\n\n \n\nA combined programme of manuscript digitisation, cataloguing and conservation will provide multiple points of entry. Researchers will see recipes in their original form: through high-resolution images viewable via the Cambridge Digital Library (CUDL), and medium-resolution images available for free download and reuse via CUDL and International Image Interoperability Framework (IIIF) manifests.\n\n \n\nFully searchable XML descriptions of the manuscripts\u2019 contents, physical characteristics, and histories will be published alongside, revealing the intellectual and material contexts in which these texts were circulated and received. Adhering to interoperable TEI guidelines, these descriptions will facilitate cross-collection discovery, building strong links with comparable manuscripts in Oxford and Manchester.\n\n \n\nHyperdiplomatic transcriptions, created using Transkribus, will provide a level of detail unmatched by existing finding aids, enabling keyword searching and granular, computational analysis of the recipes. The project will empower other organisations to undertake similar work with their collections by creating a robust and extensible methodology, and disseminating it through a website, workshops and symposium for researchers, curators and libraries.\n","plannedDates":[{"endDate":"2024-02-29T00:00:00+00:00","startDate":"2022-03-01T00:00:00+00:00","startDateDateOnly":"2022-03-01","endDateDateOnly":"2024-02-29"}],"amountAwarded":493456,"Financial Year":"2020/21","Lead Applicant":"Dr James Freeman","grantProgramme":[{"title":"Research Resources Award","title_keyword":"Research Resources Award"}],"Applicant Surname":"Freeman","Partnership Value":493456,"Approval Committee":"Research Resources Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Cambridge","name":"University of Cambridge","addressCountry":"United Kingdom","id_and_name":"[\"University of Cambridge\", \"360G-Wellcome-ORG:University-of-Cambridge\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Cambridge","name":"University of Cambridge"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Curious cures: enhancing the discoverability of medieval medical recipes This two-year, collaborative project will open up to health researchers worldwide 187 medieval manuscripts containing medical recipes across Cambridge collections, and the currently inaccessible corpus of approximately 8000 Latin and Middle English medical recipes that they contain.\n\n \n\nA combined programme of manuscript digitisation, cataloguing and conservation will provide multiple points of entry. Researchers will see recipes in their original form: through high-resolution images viewable via the Cambridge Digital Library (CUDL), and medium-resolution images available for free download and reuse via CUDL and International Image Interoperability Framework (IIIF) manifests.\n\n \n\nFully searchable XML descriptions of the manuscripts\u2019 contents, physical characteristics, and histories will be published alongside, revealing the intellectual and material contexts in which these texts were circulated and received. Adhering to interoperable TEI guidelines, these descriptions will facilitate cross-collection discovery, building strong links with comparable manuscripts in Oxford and Manchester.\n\n \n\nHyperdiplomatic transcriptions, created using Transkribus, will provide a level of detail unmatched by existing finding aids, enabling keyword searching and granular, computational analysis of the recipes. The project will empower other organisations to undertake similar work with their collections by creating a robust and extensible methodology, and disseminating it through a website, workshops and symposium for researchers, curators and libraries.\n","awardDateDateOnly":"2021-05-20","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223653_Z_21_Z","title":"Exploring Disability: an archive and history of disabled people\u2019s experience of disability and the journey from a medical to a social model perspective.","Region":"North East","currency":"GBP","awardDate":"2021-05-20T00:00:00+00:00","Internal ID":"223653/Z/21/Z","description":"The GMCDP archive collection reveals the changing perspectives, language and attitudes towards disabled people that have occurred over recent decades. It highlights changes in medical practices, discussions and debates around bio-ethics and end of life issues, campaigns for independent living, the self-organisation of disabled people, development of disability culture, and the significant impact of wider health determinants (education, income/poverty levels, employment, housing etc). The GMCDP Archive is the largest, most comprehensive archive of the lives and experience of disabled people and the activism in England (JT Assessment)\n\nThe project will:\n\n\n Work with Archives+ to catalogue and classify the collection.\n Make the catalogue available online.\n Establish a viable and sustainable system for viewing the collection (providing physical access to research material).\n Make parts of the collection available digitally online (e.g. seminal papers).\n Ensure that all openly available material is presented for viewing in a range of accessible formats and that there is an on-going system in place to transcribe new and/or restricted material. A significant challenge, but essential element of the project.\n Share our learning on making collections fully accessible by developing guidance and toolkits, delivering workshops and training to other collection holders.\n Connect with relevant institutions to promote the resource.\n\n","plannedDates":[{"endDate":"2024-10-14T00:00:00+00:00","startDate":"2021-10-15T00:00:00+00:00","startDateDateOnly":"2021-10-15","endDateDateOnly":"2024-10-14"}],"amountAwarded":308990,"Financial Year":"2020/21","Lead Applicant":"Miss Nicola McDonagh","grantProgramme":[{"title":"Research Resources Award","title_keyword":"Research Resources Award"}],"Applicant Surname":"McDonagh","Partnership Value":308990,"Approval Committee":"Research Resources Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Greater-Manchester-Coalition-of-Disabled-People","name":"Greater Manchester Coalition of Disabled People","addressCountry":"United Kingdom","id_and_name":"[\"Greater Manchester Coalition of Disabled People\", \"360G-Wellcome-ORG:Greater-Manchester-Coalition-of-Disabled-People\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Greater-Manchester-Coalition-of-Disabled-People","name":"Greater Manchester Coalition of Disabled People"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Exploring Disability: an archive and history of disabled people\u2019s experience of disability and the journey from a medical to a social model perspective. The GMCDP archive collection reveals the changing perspectives, language and attitudes towards disabled people that have occurred over recent decades. It highlights changes in medical practices, discussions and debates around bio-ethics and end of life issues, campaigns for independent living, the self-organisation of disabled people, development of disability culture, and the significant impact of wider health determinants (education, income/poverty levels, employment, housing etc). The GMCDP Archive is the largest, most comprehensive archive of the lives and experience of disabled people and the activism in England (JT Assessment)\n\nThe project will:\n\n\n Work with Archives+ to catalogue and classify the collection.\n Make the catalogue available online.\n Establish a viable and sustainable system for viewing the collection (providing physical access to research material).\n Make parts of the collection available digitally online (e.g. seminal papers).\n Ensure that all openly available material is presented for viewing in a range of accessible formats and that there is an on-going system in place to transcribe new and/or restricted material. A significant challenge, but essential element of the project.\n Share our learning on making collections fully accessible by developing guidance and toolkits, delivering workshops and training to other collection holders.\n Connect with relevant institutions to promote the resource.\n\n","awardDateDateOnly":"2021-05-20","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223651_Z_21_Z","title":"Emergency oxygen response for COVID-19","Region":"International","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223651/Z/21/Z","description":"The O2 Taskforce is coordinating access to emergency oxygen for COVID-19 patients in LMICs. Since the start of the pandemic, affordable, sustainable access to oxygen has been a growing challenge LMICs. COVID-19 has put huge pressure on health systems, with hospitals running out of oxygen, has resulted in preventable deaths and huge burden on families of hospitalized patients. Oxygen is an essential medicine, and despite being vital for the effective treatment of hospitalized COVID-19 patients, access in LMICs is limited due to cost, infrastructure and logistical barriers. The O2 Taskforce has identified an immediate need of approx. US$ 90 million over the next 1 \u2013 2 months, with a US$1.6 billion need estimated for LMICs over the next 12 months to support.\n\n \n\nThe proposal will secure funding ($10 million) for acute oxygen COVID-19 needs in LMICs as identified by the O2 Taskforce. The funds will support countries to access oxygen and to unlock available resources to build more sustainable, resilient oxygen systems. Activities may include technical assistance for implementation of oxygen services, investments for market interventions and for additional country assessments/development of country funding proposals. This investment is intended to accelerate and amplify the impact of follow on scale-up funding.","plannedDates":[{"endDate":"2022-02-16T00:00:00+00:00","startDate":"2021-05-18T00:00:00+00:00","startDateDateOnly":"2021-05-18","endDateDateOnly":"2022-02-16"}],"amountAwarded":7247952,"Financial Year":"2020/21","Lead Applicant":"Dr Philippe Duneton","grantProgramme":[{"title":"Coronavirus","title_keyword":"Coronavirus"}],"Applicant Surname":"Duneton","Partnership Value":7247952,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:World-Health-Organization-Switzerland","name":"World Health Organization, Switzerland","addressCountry":"Switzerland","id_and_name":"[\"World Health Organization, Switzerland\", \"360G-Wellcome-ORG:World-Health-Organization-Switzerland\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:World-Health-Organization-Switzerland","name":"World Health Organization, Switzerland"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Emergency oxygen response for COVID-19 The O2 Taskforce is coordinating access to emergency oxygen for COVID-19 patients in LMICs. Since the start of the pandemic, affordable, sustainable access to oxygen has been a growing challenge LMICs. COVID-19 has put huge pressure on health systems, with hospitals running out of oxygen, has resulted in preventable deaths and huge burden on families of hospitalized patients. Oxygen is an essential medicine, and despite being vital for the effective treatment of hospitalized COVID-19 patients, access in LMICs is limited due to cost, infrastructure and logistical barriers. The O2 Taskforce has identified an immediate need of approx. US$ 90 million over the next 1 \u2013 2 months, with a US$1.6 billion need estimated for LMICs over the next 12 months to support.\n\n \n\nThe proposal will secure funding ($10 million) for acute oxygen COVID-19 needs in LMICs as identified by the O2 Taskforce. The funds will support countries to access oxygen and to unlock available resources to build more sustainable, resilient oxygen systems. Activities may include technical assistance for implementation of oxygen services, investments for market interventions and for additional country assessments/development of country funding proposals. This investment is intended to accelerate and amplify the impact of follow on scale-up funding.","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223642_Z_21_Z","title":"Research on Research Institute \u2013 CWTS-Leiden Costs - 2021","Region":"International","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223642/Z/21/Z","description":"Not available","plannedDates":[{"endDate":"2021-09-30T00:00:00+00:00","startDate":"2021-01-01T00:00:00+00:00","startDateDateOnly":"2021-01-01","endDateDateOnly":"2021-09-30"}],"amountAwarded":39956,"Financial Year":"2020/21","Lead Applicant":"Prof Sarah De Rijcke","grantProgramme":[{"title":"Research on Research Institute Grant ","title_keyword":"Research on Research Institute Grant "}],"Applicant Surname":"De Rijcke","Partnership Value":39956,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Leiden","name":"University of Leiden","addressCountry":"Netherlands","id_and_name":"[\"University of Leiden\", \"360G-Wellcome-ORG:University-of-Leiden\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Leiden","name":"University of Leiden"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Research on Research Institute \u2013 CWTS-Leiden Costs - 2021 Not available","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223633_Z_21_Z","title":"Inequalities in Longevity by Education in OECD Countries ","Region":"Yorkshire and the Humber","currency":"GBP","awardDate":"2021-06-18T00:00:00+00:00","Internal ID":"223633/Z/21/Z","description":"Socioeconomic inequalities in health are an increasingly central policy concern and accurate measurement is crucial in identifying effective policies to reduce health inequalities. I propose updating and refining previous OECD work examining inequalities in longevity by education in member countries around 2011. Updating the analysis involves using more recent data from national mortality registers linked to administrative data on education. Refining the analysis involves applying appropriate methods to allow for biases due to missing data. This is important since education data are often collected via the workforce, so there may be systematic patterns of missingness relating to non-participation in the workforce, which are associated with education.\n\n \n\nThe key goal is to devise a robust methodology for routinely calculating educational inequalities in longevity in a time- and labour-effective manner. The project contributes to the OECD mission of promoting wellbeing, and specifically the OECD work package \u2018Health inequalities and inclusive growth\u2019 and report \u2018Health at a Glance\u2019. It will also help the OECD become the main authority on educational longevity inequalities in member countries.\n","plannedDates":[{"endDate":"2022-01-04T00:00:00+00:00","startDate":"2021-07-05T00:00:00+00:00","startDateDateOnly":"2021-07-05","endDateDateOnly":"2022-01-04"}],"amountAwarded":15306,"Financial Year":"2020/21","Lead Applicant":"Mr Christopher L\u00fcbker","grantProgramme":[{"title":"WT/POST Fellowship","title_keyword":"WT/POST Fellowship"}],"Applicant Surname":"L\u00fcbker","Partnership Value":15306,"Approval Committee":"Secondment Fellowship Interview Committee","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-York","name":"University of York","addressCountry":"United Kingdom","id_and_name":"[\"University of York\", \"360G-Wellcome-ORG:University-of-York\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-York","name":"University of York"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Inequalities in Longevity by Education in OECD Countries Socioeconomic inequalities in health are an increasingly central policy concern and accurate measurement is crucial in identifying effective policies to reduce health inequalities. I propose updating and refining previous OECD work examining inequalities in longevity by education in member countries around 2011. Updating the analysis involves using more recent data from national mortality registers linked to administrative data on education. Refining the analysis involves applying appropriate methods to allow for biases due to missing data. This is important since education data are often collected via the workforce, so there may be systematic patterns of missingness relating to non-participation in the workforce, which are associated with education.\n\n \n\nThe key goal is to devise a robust methodology for routinely calculating educational inequalities in longevity in a time- and labour-effective manner. The project contributes to the OECD mission of promoting wellbeing, and specifically the OECD work package \u2018Health inequalities and inclusive growth\u2019 and report \u2018Health at a Glance\u2019. It will also help the OECD become the main authority on educational longevity inequalities in member countries.\n","awardDateDateOnly":"2021-06-18","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223625_Z_21_Z","title":"UK participation in EU Joint Action - 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The work will establish the best practice in quantifying the burden of AMR through the comparative analysis of selected data sets from the GRAM project and synthetic data generated using mechanistic models. Key goals include comparative estimates of the burden of AMR for selected data sets and evaluations of the appropriateness of different analytical approaches for different types of data and different epidemiological processes. In particular, the work will determine: i) under what circumstances the assumption that resistant infections fully replace sensitive infections with the same species is appropriate for quantifying the burden of AMR; ii) under what circumstances the contrasting assumption that resistant infections add to the burden rather than replacing sensitive infections is appropriate; and iii) under what circumstances the intermediate assumption of partial replacement is appropriate. \n","awardDateDateOnly":"2021-05-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223604_Z_21_Z","title":"Developing Snakebite Research Hubs- Improving Evidence based decision making in Snakebite in Africa","Region":"North West","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223604/Z/21/Z","description":"Snakebite has recently been recognised as a Neglected Tropical Disease, In addition to the limited availability of high quality antivenoms, one of the major challenges to improving outcomes is that there is currently no established mechanism for a) determining the key evidence gaps, b) coordinating the necessary research and evidence generation and c) providing appropriate scientific and technical advice to governments and Ministries of Health to inform appropriate policy development.\n\nThis application seeks to undertake the initial work necessary for planning how these public health and policy issues could be addressed in sub-Saharan Africa. 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We propose working for ~4 weeks to help refine and build out what this proof of concept would look like - specifically as it relates to the flow, curriculum and approach of the pilot programme. \n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223553_Z_21_Z","title":"Assessing the prospective impacts of Universal Basic Income on anxiety and depression among 14-24-year-olds","Region":"North West","currency":"GBP","awardDate":"2021-05-31T00:00:00+00:00","Internal ID":"223553/Z/21/Z","description":"In a context of austerity, pandemic and unemployment, 14- to 24-year-olds have above-average levels of anxiety, significant rates of depression and lower life satisfaction than previous cohorts. Building on our model of upstream socioeconomic pathways for health impact, this project examines prospective impact of Universal Basic Income, a system of unconditional cash transfers, on anxiety and depression among 14-24s. It brings together an established, multi-disciplinary team to:\n\nObjective 1) create a \u2018risk\u2019 factor for anxiety and depression among 14-24s from existing data\n\nO2) deploy the RSA\u2019s Citizen Engagement Workshops and focus groups with disabled people to advance designs for a \u2018transitional UBI\u2019 for 14-17s, an overall scheme aimed specifically at mental health impact, and account for additional needs\n\nO3) use the \u2018risk\u2019 factor to model the impact of the cash transfer schemes from 2) on anxiety and depression among 14-24s\n\nO4) design research protocols to measure impacts in different schemes using the examples of ActEarly\u2019s Bradford pilot and the RSA/Scottish Government\u2019s prospective Dunfermline trial\n\nThis will lead to a series of publications, an end of project report published by the RSA and a set of impact measurement research materials. We will seek to \u2018leverage\u2019 these to secure further funded research.\n","plannedDates":[{"endDate":"2022-01-30T00:00:00+00:00","startDate":"2021-08-01T00:00:00+00:00","startDateDateOnly":"2021-08-01","endDateDateOnly":"2022-01-30"}],"amountAwarded":163036,"Financial Year":"2020/21","Lead Applicant":"Dr Matthew Johnson","grantProgramme":[{"title":"Discretionary Award - Mental Health","title_keyword":"Discretionary Award - Mental Health"}],"Applicant Surname":"Johnson","Partnership Value":163036,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Lancaster-University","name":"Lancaster University","addressCountry":"United Kingdom","id_and_name":"[\"Lancaster University\", \"360G-Wellcome-ORG:Lancaster-University\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Lancaster-University","name":"Lancaster University"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Assessing the prospective impacts of Universal Basic Income on anxiety and depression among 14-24-year-olds In a context of austerity, pandemic and unemployment, 14- to 24-year-olds have above-average levels of anxiety, significant rates of depression and lower life satisfaction than previous cohorts. Building on our model of upstream socioeconomic pathways for health impact, this project examines prospective impact of Universal Basic Income, a system of unconditional cash transfers, on anxiety and depression among 14-24s. It brings together an established, multi-disciplinary team to:\n\nObjective 1) create a \u2018risk\u2019 factor for anxiety and depression among 14-24s from existing data\n\nO2) deploy the RSA\u2019s Citizen Engagement Workshops and focus groups with disabled people to advance designs for a \u2018transitional UBI\u2019 for 14-17s, an overall scheme aimed specifically at mental health impact, and account for additional needs\n\nO3) use the \u2018risk\u2019 factor to model the impact of the cash transfer schemes from 2) on anxiety and depression among 14-24s\n\nO4) design research protocols to measure impacts in different schemes using the examples of ActEarly\u2019s Bradford pilot and the RSA/Scottish Government\u2019s prospective Dunfermline trial\n\nThis will lead to a series of publications, an end of project report published by the RSA and a set of impact measurement research materials. We will seek to \u2018leverage\u2019 these to secure further funded research.\n","awardDateDateOnly":"2021-05-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223550_Z_21_Z","title":"The International Digital Health & AI Research Collaborative (I-DAIR)","Region":"International","currency":"GBP","awardDate":"2021-05-31T00:00:00+00:00","Internal ID":"223550/Z/21/Z","description":"I-DAIR is a Geneva-based global platform to enable inclusive, impactful, and responsible research into digital health and Artificial Intelligence (AI) for health. I-DAIR\u2019s mission is the transformation of personal and public health through collaborative research and development of digital technologies. This proposal for a grant of GBP 2 million over two years (2021- 2022) to fund the key capabilities necessary for I-DAIR to fulfill its primary functions as an enabler of digital health and as a convener of key stakeholders for digital health. The grant will complement a CHF 7 million (GBP 5.4 million) investment by Fondation Botnar, which has allowed I-DAIR to start building a Project Team and begin a two year incubation phase, with launch scheduled for 2022. By enabling key strategic outcomes, Wellcome\u2019s contribution will allow the Project Team to make the case for I-DAIR at launch as a global catalyst for digital health and artificial intelligence (AI) research and development (R & D), and for democratising the R & D landscape by bringing more attention to networks, needs and opportunities in low-and middle-income countries. \n","plannedDates":[{"endDate":"2023-06-30T00:00:00+00:00","startDate":"2021-07-01T00:00:00+00:00","startDateDateOnly":"2021-07-01","endDateDateOnly":"2023-06-30"}],"amountAwarded":1982664,"Financial Year":"2020/21","Lead Applicant":"Dr Amandeep Gill","grantProgramme":[{"title":"Discretionary Award \u2013 DSH","title_keyword":"Discretionary Award \u2013 DSH"}],"Applicant Surname":"Gill","Partnership Value":1982664,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:The-Graduate-Institute-of-International-and-Development-Studies","name":"The Graduate Institute of International and Development Studies","addressCountry":"Switzerland","id_and_name":"[\"The Graduate Institute of International and Development Studies\", \"360G-Wellcome-ORG:The-Graduate-Institute-of-International-and-Development-Studies\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:The-Graduate-Institute-of-International-and-Development-Studies","name":"The Graduate Institute of International and Development Studies"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"The International Digital Health & AI Research Collaborative (I-DAIR) I-DAIR is a Geneva-based global platform to enable inclusive, impactful, and responsible research into digital health and Artificial Intelligence (AI) for health. I-DAIR\u2019s mission is the transformation of personal and public health through collaborative research and development of digital technologies. This proposal for a grant of GBP 2 million over two years (2021- 2022) to fund the key capabilities necessary for I-DAIR to fulfill its primary functions as an enabler of digital health and as a convener of key stakeholders for digital health. The grant will complement a CHF 7 million (GBP 5.4 million) investment by Fondation Botnar, which has allowed I-DAIR to start building a Project Team and begin a two year incubation phase, with launch scheduled for 2022. By enabling key strategic outcomes, Wellcome\u2019s contribution will allow the Project Team to make the case for I-DAIR at launch as a global catalyst for digital health and artificial intelligence (AI) research and development (R & D), and for democratising the R & D landscape by bringing more attention to networks, needs and opportunities in low-and middle-income countries. \n","awardDateDateOnly":"2021-05-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223542_Z_21_Z","title":"Independent High-Level Panel: Financing for Pandemic Prevention, Preparedness and Response","Region":"International","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"223542/Z/21/Z","description":" \n\nA high-level panel, led by co-chairs Tharman Shanmugaratnam, Lawrence H. Summers and Ngozi Okonjo-Iweala, has been mandated by the Italian presidency of the G20 to propose reforms and other measures that will lead to more reliable and sustainable financing of pandemic prevention, preparedness, and response. To support the deliberations and decision-making of the panel, Bruegel and CGD will establish a team to lead the analysis and content development of the proposals. The work of the project team and the panel is aimed at eliciting concrete and cooperative action by the G20 finance ministers. The team will develop an outline for the final report of the panel for discussion and feedback with the co-Chairs. Furthermore, the team will carry out three background analyses that will enable the informed discussion and brainstorming among panel members and the development of financing proposals: i/ landscaping current financing and issues, existing asks and proposals, ii/ landscaping current financing and issues, existing asks and proposals and iii/ governance, organization, and incentives. Reflecting the panel\u2019s views as well as the teams\u2019 own analyses, a draft and then final report will be developed building on the initial outline and the background analyses and consultations. \n","plannedDates":[{"endDate":"2021-10-31T00:00:00+00:00","startDate":"2021-02-01T00:00:00+00:00","startDateDateOnly":"2021-02-01","endDateDateOnly":"2021-10-31"}],"amountAwarded":139270,"Financial Year":"2020/21","Lead Applicant":"Ms Scarlett Varga","grantProgramme":[{"title":"Discretionary Award - Policy ","title_keyword":"Discretionary Award - Policy "}],"Applicant Surname":"Varga","Partnership Value":139270,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Bruegel","name":"Bruegel","addressCountry":"Belgium","id_and_name":"[\"Bruegel\", \"360G-Wellcome-ORG:Bruegel\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Bruegel","name":"Bruegel"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Independent High-Level Panel: Financing for Pandemic Prevention, Preparedness and Response \n\nA high-level panel, led by co-chairs Tharman Shanmugaratnam, Lawrence H. Summers and Ngozi Okonjo-Iweala, has been mandated by the Italian presidency of the G20 to propose reforms and other measures that will lead to more reliable and sustainable financing of pandemic prevention, preparedness, and response. To support the deliberations and decision-making of the panel, Bruegel and CGD will establish a team to lead the analysis and content development of the proposals. The work of the project team and the panel is aimed at eliciting concrete and cooperative action by the G20 finance ministers. The team will develop an outline for the final report of the panel for discussion and feedback with the co-Chairs. Furthermore, the team will carry out three background analyses that will enable the informed discussion and brainstorming among panel members and the development of financing proposals: i/ landscaping current financing and issues, existing asks and proposals, ii/ landscaping current financing and issues, existing asks and proposals and iii/ governance, organization, and incentives. Reflecting the panel\u2019s views as well as the teams\u2019 own analyses, a draft and then final report will be developed building on the initial outline and the background analyses and consultations. \n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223541_Z_21_Z","title":"What influences cancer services uptake in Ghana and how can this information support policy-making?","Region":"Yorkshire and the Humber","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"223541/Z/21/Z","description":"My research is about what influences people in Ghana to use cancer services. Cancer is an increasing problem in Ghana due to changes to lifestyle and population age. Many things influence cancer services use including, disease beliefs, stigma, healthcare trust, and costs. The Ghanaian health system seeks to expand cancer services in a way that benefits as many as possible, but challenges remain in understanding why some patients do not attend.\n\n\nI plan to use mixed methods to explore what influences cancer service use and how this information can be useful for Ghanaian policymakers. A key stage will involve surveying public members\u2019 beliefs and behaviours. I will analyse data collected to see how information about age, gender and job relate to peoples\u2019 views and might influence whether they would use cancer services; I also hope to build profiles of types of people to help policymakers target help to those most in need. To further understand and check the analysis, I will use narrative interviews with a range of the public to listen to what they think and why they act as they do.\n\n\nI will bring together the findings and discuss with policymakers how this could help inform their decision-making.\n","plannedDates":[{"endDate":"2023-09-01T00:00:00+00:00","startDate":"2020-09-02T00:00:00+00:00","startDateDateOnly":"2020-09-02","endDateDateOnly":"2023-09-01"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Ms Chloe Tuck","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Tuck","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Sheffield","name":"University of Sheffield","addressCountry":"United Kingdom","id_and_name":"[\"University of Sheffield\", \"360G-Wellcome-ORG:University-of-Sheffield\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Sheffield","name":"University of Sheffield"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"What influences cancer services uptake in Ghana and how can this information support policy-making? My research is about what influences people in Ghana to use cancer services. Cancer is an increasing problem in Ghana due to changes to lifestyle and population age. Many things influence cancer services use including, disease beliefs, stigma, healthcare trust, and costs. The Ghanaian health system seeks to expand cancer services in a way that benefits as many as possible, but challenges remain in understanding why some patients do not attend.\n\n\nI plan to use mixed methods to explore what influences cancer service use and how this information can be useful for Ghanaian policymakers. A key stage will involve surveying public members\u2019 beliefs and behaviours. I will analyse data collected to see how information about age, gender and job relate to peoples\u2019 views and might influence whether they would use cancer services; I also hope to build profiles of types of people to help policymakers target help to those most in need. To further understand and check the analysis, I will use narrative interviews with a range of the public to listen to what they think and why they act as they do.\n\n\nI will bring together the findings and discuss with policymakers how this could help inform their decision-making.\n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223535_Z_21_Z","title":"RSTMH small grants for snakebite 2021-23","Region":"Greater London","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"223535/Z/21/Z","description":"Snakebite is a strategic priority for RSTMH given its high levels of death and disability. Although there has been an increase in research funding recently, there is still an unmet need to encourage junior researchers to undertake a career in snakebite research. The RSTMH Small Grants Programme is a unique grant funding programme open to early career researchers from anywhere in the world that aims to fill a gap in the research career pathway. RSTMH grants are for up to \u00a35,000 to those early in their careers (e.g. researchers, healthcare professionals, NGO workers, health economists, social scientists) who are working in a field relevant to tropical medicine or global health. These grants typically represent the first time someone has received funding in their own name and helps develop their research and management skills.\n\nIn 2020, Wellcome piloted a partnership with RSMTH to fund 10 grants in snakebite research. With Wellcome funding, RSTMH awarded grants to African, Asian, South American and European nationals across various snakebite research areas. Following on from the success of the pilot, RSTMH is seeking funding for a 3-year partnership with Wellcome to fund 10 projects per year and up to 30 in total in snakebite research.\n\n \n","plannedDates":[{"endDate":"2024-06-17T00:00:00+00:00","startDate":"2021-06-18T00:00:00+00:00","startDateDateOnly":"2021-06-18","endDateDateOnly":"2024-06-17"}],"amountAwarded":166200,"Financial Year":"2020/21","Lead Applicant":"Ms Tamar Ghosh","grantProgramme":[{"title":"Discretionary Award - Snakebite","title_keyword":"Discretionary Award - Snakebite"}],"Applicant Surname":"Ghosh","Partnership Value":166200,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Royal-Society-of-Tropical-Medicine-and-Hygiene","name":"Royal Society of Tropical Medicine and Hygiene","addressCountry":"United Kingdom","id_and_name":"[\"Royal Society of Tropical Medicine and Hygiene\", \"360G-Wellcome-ORG:Royal-Society-of-Tropical-Medicine-and-Hygiene\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Royal-Society-of-Tropical-Medicine-and-Hygiene","name":"Royal Society of Tropical Medicine and Hygiene"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"RSTMH small grants for snakebite 2021-23 Snakebite is a strategic priority for RSTMH given its high levels of death and disability. Although there has been an increase in research funding recently, there is still an unmet need to encourage junior researchers to undertake a career in snakebite research. The RSTMH Small Grants Programme is a unique grant funding programme open to early career researchers from anywhere in the world that aims to fill a gap in the research career pathway. RSTMH grants are for up to \u00a35,000 to those early in their careers (e.g. researchers, healthcare professionals, NGO workers, health economists, social scientists) who are working in a field relevant to tropical medicine or global health. These grants typically represent the first time someone has received funding in their own name and helps develop their research and management skills.\n\nIn 2020, Wellcome piloted a partnership with RSMTH to fund 10 grants in snakebite research. With Wellcome funding, RSTMH awarded grants to African, Asian, South American and European nationals across various snakebite research areas. Following on from the success of the pilot, RSTMH is seeking funding for a 3-year partnership with Wellcome to fund 10 projects per year and up to 30 in total in snakebite research.\n\n \n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223534_Z_21_Z","title":"International Health Advocacy for Climate Action -- GCHA capacity grant","Region":"International","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"223534/Z/21/Z","description":"Climate change presents a unique and urgent threat to planetary health. Compounded by the COVID19 pandemic, we face a very real risk of losing 50 years of global development, exacerbating health, economic, and social inequities.\n\nCOP26 will provide a special opportunity for global leaders to set a course for a healthy and green recovery. \n\nInformed voices from across the globe are crucial in driving decision makers to deliver ambitious climate action. Health workers are among society's most trusted and respected professionals, and the health case for climate action is powerful, offering millions of lives saved through reduced non-communicable diseases, health resilience, and adaptation, and fully offsetting the costs of mitigation through health cost savings.\n\nWellcome Trust funding will enable the Global Climate Health Alliance (GCHA) to amplify the voices of medical and other health professionals globally, including those in low and middle income countries (LMIC) which have been underrepresented in the international climate conversation, on the massive health opportunities of climate action. \n\nWe will build capacity, link new voices to media advocacy opportunities, and disseminate Wellcome coalition asks through our global networks, thereby influencing climate action at the national and international level in the run up to COP.\n\n \n","plannedDates":[{"endDate":"2021-12-31T00:00:00+00:00","startDate":"2021-04-01T00:00:00+00:00","startDateDateOnly":"2021-04-01","endDateDateOnly":"2021-12-31"}],"amountAwarded":46492,"Financial Year":"2020/21","Lead Applicant":"Dr Jennifer Miller","grantProgramme":[{"title":"Discretionary Award - OPOH","title_keyword":"Discretionary Award - OPOH"}],"Applicant Surname":"Miller","Partnership Value":46492,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Social-Good-Fund","name":"Social Good Fund","addressCountry":"United States","id_and_name":"[\"Social Good Fund\", \"360G-Wellcome-ORG:Social-Good-Fund\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Social-Good-Fund","name":"Social Good Fund"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"International Health Advocacy for Climate Action -- GCHA capacity grant Climate change presents a unique and urgent threat to planetary health. Compounded by the COVID19 pandemic, we face a very real risk of losing 50 years of global development, exacerbating health, economic, and social inequities.\n\nCOP26 will provide a special opportunity for global leaders to set a course for a healthy and green recovery. \n\nInformed voices from across the globe are crucial in driving decision makers to deliver ambitious climate action. Health workers are among society's most trusted and respected professionals, and the health case for climate action is powerful, offering millions of lives saved through reduced non-communicable diseases, health resilience, and adaptation, and fully offsetting the costs of mitigation through health cost savings.\n\nWellcome Trust funding will enable the Global Climate Health Alliance (GCHA) to amplify the voices of medical and other health professionals globally, including those in low and middle income countries (LMIC) which have been underrepresented in the international climate conversation, on the massive health opportunities of climate action. \n\nWe will build capacity, link new voices to media advocacy opportunities, and disseminate Wellcome coalition asks through our global networks, thereby influencing climate action at the national and international level in the run up to COP.\n\n \n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223533_Z_21_Z","title":"Strengthening the climate and health capacity of AfGH and SfGH ","Region":"Greater London","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"223533/Z/21/Z","description":"Action for Global Health (AfGH) and Students for Global Health (SfGH) in partnership aim to increase our respective health networks' (reaching more than 50 organisations), and members' (in 34 student branches) contribution to a shared climate and health agenda through capacity building, mobilising, and increasing collaboration between key stakeholders (our members, partners and other actors) and supporting synthesised advocacy and campaign events in the lead up to COP26. In particular we will focus on increasing access to engagement with youth, global south and NMIC stakeholders on the intersection of health and climate.\n\nWe will partner to work with the 'Climate Change Coalition' to activate and engage cross sectoral partners including global south, LMIC and youth organisations around a shared policy agenda and build support for sustainable health and climate change strategies leading up to G7 and COP26. We will actively participate in the climate coalition and build our and other actors' resources to activate and mobilise support for health and climate. We will draw on the breadth and strength of our members collective experience and expertise to actively engage with and broaden understanding of the intersection between health and climate.\n","plannedDates":[{"endDate":"2022-03-02T00:00:00+00:00","startDate":"2021-05-01T00:00:00+00:00","startDateDateOnly":"2021-05-01","endDateDateOnly":"2022-03-02"}],"amountAwarded":49936,"Financial Year":"2020/21","Lead Applicant":"Ms Gjori Langeland","grantProgramme":[{"title":"Discretionary Award - OPOH","title_keyword":"Discretionary Award - OPOH"}],"Applicant Surname":"Langeland","Partnership Value":49936,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:STOPAIDS","name":"STOPAIDS","addressCountry":"United Kingdom","id_and_name":"[\"STOPAIDS\", \"360G-Wellcome-ORG:STOPAIDS\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:STOPAIDS","name":"STOPAIDS"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Strengthening the climate and health capacity of AfGH and SfGH Action for Global Health (AfGH) and Students for Global Health (SfGH) in partnership aim to increase our respective health networks' (reaching more than 50 organisations), and members' (in 34 student branches) contribution to a shared climate and health agenda through capacity building, mobilising, and increasing collaboration between key stakeholders (our members, partners and other actors) and supporting synthesised advocacy and campaign events in the lead up to COP26. In particular we will focus on increasing access to engagement with youth, global south and NMIC stakeholders on the intersection of health and climate.\n\nWe will partner to work with the 'Climate Change Coalition' to activate and engage cross sectoral partners including global south, LMIC and youth organisations around a shared policy agenda and build support for sustainable health and climate change strategies leading up to G7 and COP26. We will actively participate in the climate coalition and build our and other actors' resources to activate and mobilise support for health and climate. We will draw on the breadth and strength of our members collective experience and expertise to actively engage with and broaden understanding of the intersection between health and climate.\n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223532_Z_21_Z","title":"Secretariat Support for G20 High Level Independent Panel (HLIP) ","Region":"International","currency":"GBP","awardDate":"2021-05-31T00:00:00+00:00","Internal ID":"223532/Z/21/Z","description":"The G20, as proposed by the Italian G20 Presidency, has mandated a High-Level Independent Panel (HLIP) to recommend actionable solutions for reliable and sustainable financing of the global commons for pandemic prevention, surveillance, preparedness and response. The Panel\u2019s recommendations will be presented to the G20 Finance Ministers and Central Bank Governors Meeting in July. To provide the HLIP with support for logistics, coordination, outreach, and communication/engagement, The National Academy of Medicine (NAM) proposes to establish a joint Secretariat comprised of 4-5 individuals from the NAM and the Wellcome Trust. From February through October 2021, it is expected that the joint Secretariat will support the execution of the independent review by the HLIP. The work of the Secretariat during these eight months will include: 1) meeting logistics and organization; 2) meeting facilitation (agenda setting, conduct, and procedures); 3) outreach and communication with key political and other stakeholders; and, as needed 4) limited research/analytical/writing support for health-related content.\n","plannedDates":[{"endDate":"2021-10-31T00:00:00+00:00","startDate":"2021-02-01T00:00:00+00:00","startDateDateOnly":"2021-02-01","endDateDateOnly":"2021-10-31"}],"amountAwarded":198620,"Financial Year":"2020/21","Lead Applicant":"Mrs Morgan Kanarek","grantProgramme":[{"title":"Discretionary Award - Policy ","title_keyword":"Discretionary Award - Policy "}],"Applicant Surname":"Kanarek","Partnership Value":198620,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:National-Academy-of-Sciences-America-NAS","name":"National Academy of Sciences, America (NAS)","addressCountry":"United States","id_and_name":"[\"National Academy of Sciences, America (NAS)\", \"360G-Wellcome-ORG:National-Academy-of-Sciences-America-NAS\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:National-Academy-of-Sciences-America-NAS","name":"National Academy of Sciences, America (NAS)"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Secretariat Support for G20 High Level Independent Panel (HLIP) The G20, as proposed by the Italian G20 Presidency, has mandated a High-Level Independent Panel (HLIP) to recommend actionable solutions for reliable and sustainable financing of the global commons for pandemic prevention, surveillance, preparedness and response. The Panel\u2019s recommendations will be presented to the G20 Finance Ministers and Central Bank Governors Meeting in July. To provide the HLIP with support for logistics, coordination, outreach, and communication/engagement, The National Academy of Medicine (NAM) proposes to establish a joint Secretariat comprised of 4-5 individuals from the NAM and the Wellcome Trust. From February through October 2021, it is expected that the joint Secretariat will support the execution of the independent review by the HLIP. The work of the Secretariat during these eight months will include: 1) meeting logistics and organization; 2) meeting facilitation (agenda setting, conduct, and procedures); 3) outreach and communication with key political and other stakeholders; and, as needed 4) limited research/analytical/writing support for health-related content.\n","awardDateDateOnly":"2021-05-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223488_Z_21_Z","title":"Decolonization and global health research: initiating an African centred exchange","Region":"South East","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223488/Z/21/Z","description":"This award will support a series of interactions between academics from diverse backgrounds with a shared interest in mapping, analyzing and critically unpacking decolonization debates in global health research. Decolonization discussions and activism have become far more prominent over the last year, bringing both opportunities for positive transformation (through disruption, change and renewed interest in global power inequities) as well as challenges (including the \u2018trending\u2019 of the decolonization agenda leading to \u2013 at worst \u2013 the \u2018colonization\u2019 of the arena itself). Now, as much as ever, decolonization discussions and debates need to be critically examined. We will organize a set of exchanges and activities to: 1 Unpack and reflect upon the term \u2018global health research\u2019 using a decolonization lens; 2 Examine how tacit, or embedded, forms of knowledge from Africa are drawn upon and feature in global health research; 3 Imagine what a decolonized or African-centred, and ethical, research initiative in global health might look like; and 4 Share our learning, advocate for change, and identify an African home for future work. We will incorporate a covid-19 research lens, but only in recognition that covid-19 will shine a light upon or amplify far longer and deeper policies and processes. \n","plannedDates":[{"endDate":"2023-08-31T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00","startDateDateOnly":"2021-09-01","endDateDateOnly":"2023-08-31"}],"amountAwarded":199522,"Financial Year":"2020/21","Lead Applicant":"Prof Catherine Molyneux","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"Molyneux","Partnership Value":199522,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Decolonization and global health research: initiating an African centred exchange This award will support a series of interactions between academics from diverse backgrounds with a shared interest in mapping, analyzing and critically unpacking decolonization debates in global health research. Decolonization discussions and activism have become far more prominent over the last year, bringing both opportunities for positive transformation (through disruption, change and renewed interest in global power inequities) as well as challenges (including the \u2018trending\u2019 of the decolonization agenda leading to \u2013 at worst \u2013 the \u2018colonization\u2019 of the arena itself). Now, as much as ever, decolonization discussions and debates need to be critically examined. We will organize a set of exchanges and activities to: 1 Unpack and reflect upon the term \u2018global health research\u2019 using a decolonization lens; 2 Examine how tacit, or embedded, forms of knowledge from Africa are drawn upon and feature in global health research; 3 Imagine what a decolonized or African-centred, and ethical, research initiative in global health might look like; and 4 Share our learning, advocate for change, and identify an African home for future work. We will incorporate a covid-19 research lens, but only in recognition that covid-19 will shine a light upon or amplify far longer and deeper policies and processes. \n","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223483_Z_21_Z","title":"SA-UK/MH: Medical Humanities co-working between South Africa and the UK.","Region":"Scotland","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223483/Z/21/Z","description":"This programme of exchange and networking will:\n\ni. Energise the Medical Humanities research ecosystem in South Africa as it evolves.\n\nii. Embed the research environment at the CSHHH Glasgow, and its current partners, in this process.\n\niii. Seed a cohort of early-career scholars in the Medical Humanities with experience of research, training and teaching collectively in both South Africa and the UK.\n\n \n\nContext\n\nSince 2018 members of the CSHHH Glasgow and the University of Johannesburg have worked together in the Medical Humanities. The Wellcome Trust and both universities invested in these activities. Following the success of this co-working, partners from the University of the Witwatersrand and the University of Cape Town joined the collaboration. The core objective is to connect the four institutions in order to jointly conduct research, training and teaching so that Medical Humanities research ecosystems continue to grow together in both countries.\n\n \n\nActivities\n\nThe focus is on seeding those ecosystems through investment in the researchers of the future and fresh collaboration across the countries and institutions. The programme will enable;\n\n1. Four Masters students and one Ph.D. candidate to be co-supervised by the PIs.\n\n2. Enhanced networking and communications capacity, including new online resources and platforms.\n\n \n","plannedDates":[{"endDate":"2024-07-31T00:00:00+00:00","startDate":"2021-08-01T00:00:00+00:00","startDateDateOnly":"2021-08-01","endDateDateOnly":"2024-07-31"}],"amountAwarded":190026,"Financial Year":"2020/21","Lead Applicant":"Prof James Mills","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"Mills","Partnership Value":190026,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Strathclyde","name":"University of Strathclyde","addressCountry":"United Kingdom","id_and_name":"[\"University of Strathclyde\", \"360G-Wellcome-ORG:University-of-Strathclyde\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Strathclyde","name":"University of Strathclyde"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"SA-UK/MH: Medical Humanities co-working between South Africa and the UK. This programme of exchange and networking will:\n\ni. Energise the Medical Humanities research ecosystem in South Africa as it evolves.\n\nii. Embed the research environment at the CSHHH Glasgow, and its current partners, in this process.\n\niii. Seed a cohort of early-career scholars in the Medical Humanities with experience of research, training and teaching collectively in both South Africa and the UK.\n\n \n\nContext\n\nSince 2018 members of the CSHHH Glasgow and the University of Johannesburg have worked together in the Medical Humanities. The Wellcome Trust and both universities invested in these activities. Following the success of this co-working, partners from the University of the Witwatersrand and the University of Cape Town joined the collaboration. The core objective is to connect the four institutions in order to jointly conduct research, training and teaching so that Medical Humanities research ecosystems continue to grow together in both countries.\n\n \n\nActivities\n\nThe focus is on seeding those ecosystems through investment in the researchers of the future and fresh collaboration across the countries and institutions. The programme will enable;\n\n1. Four Masters students and one Ph.D. candidate to be co-supervised by the PIs.\n\n2. Enhanced networking and communications capacity, including new online resources and platforms.\n\n \n","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223463_Z_21_Z","title":"An ethical investigation into environmental sustainability in healthcare. ","Region":"North West","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Dr Joanne Knight","Internal ID":"223463/Z/21/Z","description":"Healthcare as an industry is one of the most environmentally destructive on earth in almost every respect (e.g. energy use, harmful gas emissions, and physical waste). The enormous environmental toll of delivering healthcare is fundamentally at odds with healthcare's goal of improving health and wellbeing. Indeed, it is the drive to achieve healthcare excellence with world class medical safety and effective treatments that is ultimately so resource intensive and polluting. This project aims to address the dilemma of how to ethically make medical decisions that adequately account for patients and the environment. In particular, I am interested in how we can ethically make trade offs between what is owed to individuals, collective groups, and future generations. For example, what might be best for the treatment of an individual may harm the environment and be detrimental to collective society or future generations. What is the best course of action? I use these three groups as lenses to examine three case studies of areas of environmental concern in medicine: the environmental cost of medical treatments; medical waste production; and the environmental benefits of remote treatment. My findings aim to inform this cutting edge area of applied ethics, healthcare policy and practice.\n","plannedDates":[{"endDate":"2024-09-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00","startDateDateOnly":"2021-10-01","endDateDateOnly":"2024-09-30"}],"amountAwarded":98426,"Financial Year":"2020/21","Lead Applicant":"Dr Joshua Parker","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Parker","Partnership Value":98426,"Approval Committee":"ERG11 Social Science and Bioethics, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Lancaster-University","name":"Lancaster University","addressCountry":"United Kingdom","id_and_name":"[\"Lancaster University\", \"360G-Wellcome-ORG:Lancaster-University\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Lancaster-University","name":"Lancaster University"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"An ethical investigation into environmental sustainability in healthcare. Healthcare as an industry is one of the most environmentally destructive on earth in almost every respect (e.g. energy use, harmful gas emissions, and physical waste). The enormous environmental toll of delivering healthcare is fundamentally at odds with healthcare's goal of improving health and wellbeing. Indeed, it is the drive to achieve healthcare excellence with world class medical safety and effective treatments that is ultimately so resource intensive and polluting. This project aims to address the dilemma of how to ethically make medical decisions that adequately account for patients and the environment. In particular, I am interested in how we can ethically make trade offs between what is owed to individuals, collective groups, and future generations. For example, what might be best for the treatment of an individual may harm the environment and be detrimental to collective society or future generations. What is the best course of action? I use these three groups as lenses to examine three case studies of areas of environmental concern in medicine: the environmental cost of medical treatments; medical waste production; and the environmental benefits of remote treatment. My findings aim to inform this cutting edge area of applied ethics, healthcare policy and practice.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223461_Z_21_Z","title":"Conflict, Mental Health and Peace in Colombia: Improving Global Health Practice Through the Integration of Mental Health and Psychosocial Support (MHPSS) and Peacebuilding","Region":"Greater London","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Dr Rochelle Burgess","Internal ID":"223461/Z/21/Z","description":"With 22.1% of global conflict-affected populations afflicted by mental disorders, Mental Health and Psychosocial Support (MHPSS) has become an increasingly important set of interventions (Charlson et al., 2019). However, care has remained removed from broader socio-political and historical context. This is despite that the psychosocial\" is conceptualised as one\u2019s psychological development within, and in interaction with, the social environment (Glass, 2000). In conflict-affected contexts where social environments become strained, structural issues of reconstruction are typically managed by \"peacebuilding\" actors. In other words, MHPSS and peacebuilding remain siloed, ignoring that peace and mental health are intrinsically linked. Furthermore, interventions remain top-down and externally driven.\n\nAccordingly, this research builds atop interdisciplinary critiques of both fields and asks, \"can community-based critical psychology approaches effectively integrate and improve MHPSS and peacebuilding practice in conflict-affected areas?\". Focusing on fieldwork with conflict-affected youth in Bogot\u00e1, Colombia, this research will take a Participatory Action Research approach in collaboration with local partners and communities, whereby Critical Community Psychology theories will be applied for the development of integrated \"psychosocial peacebuilding\" approaches. Through the introduction of these theoretical and methodological innovations, a \"skeleton\" of a model can be developed to be \"fleshed out\" and implemented in other conflict-affected contexts.\n","plannedDates":[{"endDate":"2024-09-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00","startDateDateOnly":"2021-10-01","endDateDateOnly":"2024-09-30"}],"amountAwarded":127173,"Financial Year":"2020/21","Lead Applicant":"Mr Eric Frasco","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Frasco","Partnership Value":127173,"Approval Committee":"ERG11 Social Science and Bioethics, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London","addressCountry":"United Kingdom","id_and_name":"[\"University College London\", \"360G-Wellcome-ORG:University-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Conflict, Mental Health and Peace in Colombia: Improving Global Health Practice Through the Integration of Mental Health and Psychosocial Support (MHPSS) and Peacebuilding With 22.1% of global conflict-affected populations afflicted by mental disorders, Mental Health and Psychosocial Support (MHPSS) has become an increasingly important set of interventions (Charlson et al., 2019). However, care has remained removed from broader socio-political and historical context. This is despite that the psychosocial\" is conceptualised as one\u2019s psychological development within, and in interaction with, the social environment (Glass, 2000). In conflict-affected contexts where social environments become strained, structural issues of reconstruction are typically managed by \"peacebuilding\" actors. In other words, MHPSS and peacebuilding remain siloed, ignoring that peace and mental health are intrinsically linked. Furthermore, interventions remain top-down and externally driven.\n\nAccordingly, this research builds atop interdisciplinary critiques of both fields and asks, \"can community-based critical psychology approaches effectively integrate and improve MHPSS and peacebuilding practice in conflict-affected areas?\". Focusing on fieldwork with conflict-affected youth in Bogot\u00e1, Colombia, this research will take a Participatory Action Research approach in collaboration with local partners and communities, whereby Critical Community Psychology theories will be applied for the development of integrated \"psychosocial peacebuilding\" approaches. Through the introduction of these theoretical and methodological innovations, a \"skeleton\" of a model can be developed to be \"fleshed out\" and implemented in other conflict-affected contexts.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223452_Z_21_Z","title":"Renewing Phenomenological Psychopathology","Region":"West Midlands","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223452/Z/21/Z","description":"Neuroscience and genetics have failed to deliver new treatments for mental disorders. It has been suggested by the NIMH that progress in biomedical approaches has been hampered by our conceptualization and taxonomy of psychiatric disorders and psychopathology. A renewed emphasis on experiential components and first-person perspectives is required to address this problem. Historically, phenomenology, as a branch of philosophy, has provided this methodology and knowledge to the mental health sciences. However, phenomenological psychopathology remains somewhat fossilized in the humanities and social sciences of the mid-20th century. This co-led international award will (1) renew phenomenological psychopathology with the recent contributions of analytic philosophy of mind, hermeneutics, structuralist/post-structuralist philosophy, history, literature, values-based practice, developmental psychology and service user research; and (2) reinvigorate phenomenology for mental health as the philosophical science of subjectivity and first-person experience. \n\nWe will develop international scholars from across disciplines and career stages to develop their research leadership and management activities and to engage in Award activities including international exchange fellowships small grants and, knowledge exchange events. The award will commence the reconstruction of phenomenological psychopathology for the 21st century as a democratic discipline with a historicized and inclusive account of the experience of the mental disorder developed.\n \n","plannedDates":[{"endDate":"2023-10-03T00:00:00+00:00","startDate":"2021-10-04T00:00:00+00:00","startDateDateOnly":"2021-10-04","endDateDateOnly":"2023-10-03"}],"amountAwarded":201902,"Financial Year":"2020/21","Lead Applicant":"Prof Matthew Broome","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"Broome","Partnership Value":201902,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Birmingham","name":"University of Birmingham","addressCountry":"United Kingdom","id_and_name":"[\"University of Birmingham\", \"360G-Wellcome-ORG:University-of-Birmingham\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Birmingham","name":"University of Birmingham"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Renewing Phenomenological Psychopathology Neuroscience and genetics have failed to deliver new treatments for mental disorders. It has been suggested by the NIMH that progress in biomedical approaches has been hampered by our conceptualization and taxonomy of psychiatric disorders and psychopathology. A renewed emphasis on experiential components and first-person perspectives is required to address this problem. Historically, phenomenology, as a branch of philosophy, has provided this methodology and knowledge to the mental health sciences. However, phenomenological psychopathology remains somewhat fossilized in the humanities and social sciences of the mid-20th century. This co-led international award will (1) renew phenomenological psychopathology with the recent contributions of analytic philosophy of mind, hermeneutics, structuralist/post-structuralist philosophy, history, literature, values-based practice, developmental psychology and service user research; and (2) reinvigorate phenomenology for mental health as the philosophical science of subjectivity and first-person experience. \n\nWe will develop international scholars from across disciplines and career stages to develop their research leadership and management activities and to engage in Award activities including international exchange fellowships small grants and, knowledge exchange events. The award will commence the reconstruction of phenomenological psychopathology for the 21st century as a democratic discipline with a historicized and inclusive account of the experience of the mental disorder developed.\n \n","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223447_Z_21_Z","title":"The gendered harms of \u2018voluntary return\u2019: women\u2019s experiences of disrupted relatedness, bodily precariousness, and gender-based violence in the UK and Punjab","Region":"South East","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Dr Linda Mulcahy","Internal ID":"223447/Z/21/Z","description":"Since 2012, the UK\u2019s \u2018hostile environment\u2019 immigration regime has sought to precaritise non-citizens\u2019 lives, and thereby encourage their voluntary departure. In recognition of this explicitly violent objective, empirical legal scholars have increasingly sought to elucidate migrants\u2019 experiences of adversity in the UK with attention to the legal structures and practices that comprise this regime. This research will seek to expand this focus to return practices. Previous research on return has overwhelmingly focused on deportation \u2013 which comprises a minority of returns from the UK \u2013 and neglected voluntary return, despite its statistical and conceptual significance to the hostile environment regime. As voluntary return also affects far more women than deportation, the practice carries additional importance for scholars of gender and migration. Through ethnographic and narrative accounts of South Asian women\u2019s lived experiences of \u2018voluntary return\u2019 from the UK to Punjab, this research will foreground voluntary return\u2019s impacts for women\u2019s health, safety, wellbeing and relationships, and consider whether these experiences might be conceptualised as \u2018gendered harms\u2019. These findings will develop understandings of migrant women's autonomy, dignity and bodily integrity, and states' obligations to non-citizens under a political and legal system that sharply differentiates their rights from those of citizens.\n","plannedDates":[{"endDate":"2024-10-09T00:00:00+00:00","startDate":"2021-10-10T00:00:00+00:00","startDateDateOnly":"2021-10-10","endDateDateOnly":"2024-10-09"}],"amountAwarded":107696,"Financial Year":"2020/21","Lead Applicant":"Miss Vidya Ramachandran","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Ramachandran","Partnership Value":107696,"Approval Committee":"ERG11 Social Science and Bioethics, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"The gendered harms of \u2018voluntary return\u2019: women\u2019s experiences of disrupted relatedness, bodily precariousness, and gender-based violence in the UK and Punjab Since 2012, the UK\u2019s \u2018hostile environment\u2019 immigration regime has sought to precaritise non-citizens\u2019 lives, and thereby encourage their voluntary departure. In recognition of this explicitly violent objective, empirical legal scholars have increasingly sought to elucidate migrants\u2019 experiences of adversity in the UK with attention to the legal structures and practices that comprise this regime. This research will seek to expand this focus to return practices. Previous research on return has overwhelmingly focused on deportation \u2013 which comprises a minority of returns from the UK \u2013 and neglected voluntary return, despite its statistical and conceptual significance to the hostile environment regime. As voluntary return also affects far more women than deportation, the practice carries additional importance for scholars of gender and migration. Through ethnographic and narrative accounts of South Asian women\u2019s lived experiences of \u2018voluntary return\u2019 from the UK to Punjab, this research will foreground voluntary return\u2019s impacts for women\u2019s health, safety, wellbeing and relationships, and consider whether these experiences might be conceptualised as \u2018gendered harms\u2019. These findings will develop understandings of migrant women's autonomy, dignity and bodily integrity, and states' obligations to non-citizens under a political and legal system that sharply differentiates their rights from those of citizens.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223442_Z_21_Z","title":"Metropolitan Modernism, Venereal Disease and Social Hygiene, 1899-1945","Region":"Greater London","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Peter Swaab","Internal ID":"223442/Z/21/Z","description":"Following the lapse of the Contagious Diseases Acts in the late nineteenth century - legislation that allowed for the routine inspection of prostitutes in order to reduce the rates of STDs - rising rates of venereal disease created, by the outbreak of war in 1914, an atmosphere of widespread sex panic that associated the disease with moral infection, particularly in metropolitan locales. My research proposes that the venereal disease epidemic of the early twentieth century was a significant medical and cultural event of particular concern to literary modernists in and around the city, including Joyce, Woolf, Eliot and Pound, and Lawrence, and activated a nexus of interrelated concerns such as anxieties surrounding birth control, prostitution, and non-procreative intercourse. This project will demonstrate how the eugenic language of social hygiene influenced modernist aesthetic strategies and suggest that literary modernism itself contributed to emerging ideas of sexual health by reflecting contemporary fears of illness and contamination. In doing so, it will deepen our understandings of the place of the literary in the production of medical knowledge at this time, and examine the crucial role of cultural forms in the dissemination and transmission of public health discourse in the early twentieth century.\n","plannedDates":[{"endDate":"2024-09-19T00:00:00+00:00","startDate":"2021-09-20T00:00:00+00:00","startDateDateOnly":"2021-09-20","endDateDateOnly":"2024-09-19"}],"amountAwarded":95026,"Financial Year":"2020/21","Lead Applicant":"Mr Christopher Jones","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Jones","Partnership Value":95026,"Approval Committee":"ERG10 Medical Humanities, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London","addressCountry":"United Kingdom","id_and_name":"[\"University College London\", \"360G-Wellcome-ORG:University-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Metropolitan Modernism, Venereal Disease and Social Hygiene, 1899-1945 Following the lapse of the Contagious Diseases Acts in the late nineteenth century - legislation that allowed for the routine inspection of prostitutes in order to reduce the rates of STDs - rising rates of venereal disease created, by the outbreak of war in 1914, an atmosphere of widespread sex panic that associated the disease with moral infection, particularly in metropolitan locales. My research proposes that the venereal disease epidemic of the early twentieth century was a significant medical and cultural event of particular concern to literary modernists in and around the city, including Joyce, Woolf, Eliot and Pound, and Lawrence, and activated a nexus of interrelated concerns such as anxieties surrounding birth control, prostitution, and non-procreative intercourse. This project will demonstrate how the eugenic language of social hygiene influenced modernist aesthetic strategies and suggest that literary modernism itself contributed to emerging ideas of sexual health by reflecting contemporary fears of illness and contamination. In doing so, it will deepen our understandings of the place of the literary in the production of medical knowledge at this time, and examine the crucial role of cultural forms in the dissemination and transmission of public health discourse in the early twentieth century.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223422_Z_21_Z","title":"Blurring the Boundaries: A Study of Advanced Nursing Practice in the United Kingdom (1990-2010)","Region":"Yorkshire and the Humber","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Barry Doyle","Internal ID":"223422/Z/21/Z","description":"Advanced nursing practice has been of tremendous value to British healthcare. The government, NHS managers and patients alike have placed high expectations on Advanced Nurse Practitioners (ANPs), and researchers have concluded that ANPs have risen to the challenge. However, it is ironic that while ANPs have been deployed across varying sectors of British healthcare, neither the government nor the NMC - nursing's regulatory body - has placed legal parameters around the role's boundary of practice. There is no doubt that professional boundaries in healthcare have shifted. Before the 1990s, nurses had been innovatively expanding their practice boundaries in response to service needs. Consequently, the ANP role evolved under changing healthcare needs. It could be interpreted that British medical history does not understand advanced practice. Therefore this study will draw on the example of the USA and interpret such evidence to be applicable to the British context. Nursing historiography currently lacks any historical analysis of the implementation of Advanced Nurse Practitioners, their role and advance practice's evolution. This thesis will correct this oversight and be the first to write a holistic historical analysis of advanced practice's scope of practice. \n","plannedDates":[{"endDate":"2025-01-16T00:00:00+00:00","startDate":"2022-01-17T00:00:00+00:00","startDateDateOnly":"2022-01-17","endDateDateOnly":"2025-01-16"}],"amountAwarded":99326,"Financial Year":"2020/21","Lead Applicant":"Miss Kelly Swaby","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Swaby","Partnership Value":99326,"Approval Committee":"ERG10 Medical Humanities, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Huddersfield","name":"University of Huddersfield","addressCountry":"United Kingdom","id_and_name":"[\"University of Huddersfield\", \"360G-Wellcome-ORG:University-of-Huddersfield\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Huddersfield","name":"University of Huddersfield"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Blurring the Boundaries: A Study of Advanced Nursing Practice in the United Kingdom (1990-2010) Advanced nursing practice has been of tremendous value to British healthcare. The government, NHS managers and patients alike have placed high expectations on Advanced Nurse Practitioners (ANPs), and researchers have concluded that ANPs have risen to the challenge. However, it is ironic that while ANPs have been deployed across varying sectors of British healthcare, neither the government nor the NMC - nursing's regulatory body - has placed legal parameters around the role's boundary of practice. There is no doubt that professional boundaries in healthcare have shifted. Before the 1990s, nurses had been innovatively expanding their practice boundaries in response to service needs. Consequently, the ANP role evolved under changing healthcare needs. It could be interpreted that British medical history does not understand advanced practice. Therefore this study will draw on the example of the USA and interpret such evidence to be applicable to the British context. Nursing historiography currently lacks any historical analysis of the implementation of Advanced Nurse Practitioners, their role and advance practice's evolution. This thesis will correct this oversight and be the first to write a holistic historical analysis of advanced practice's scope of practice. \n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223410_Z_21_Z","title":"Temporalities in Tension: Rethinking Healthcare Provisions for Sexual Migrants","Region":"Greater London","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Dr Claire Thomson","Internal ID":"223410/Z/21/Z","description":"This work responds to a growing volume of research on the wellbeing of sexual migrants. Little attention has been paid to defining migration in this literature, which is often understood in a purely spatial sense. In this project, I claim that sexual migrants \u2013 whether from the UK or abroad \u2013 traverse temporal, as well as spatial, boundaries. This, I claim, has important implications for sexual wellbeing and risk. Through ethnographic research in a London sexual health clinic, including two sets of 15 semi-structured interviews with service users and ten interviews with clinic staff, I seek to uncover the extent to which abrupt shifts between timelines, such as coming out of the closet, transitioning, or moving to radically new environments such as halls of residence or retirement homes, contribute to sexual risk. This research will problematise racist and imperialist geographies of risk that locate risk in faraway lands, while also bringing to light corrective measures that will improve patient experiences and health outcomes of temporal migrants, from wherever they originate. These measures include a recalibration of eligibility criteria for targeted risk reduction interventions and an identification of further training needs for sexual health staff working with temporal migrants.\n","plannedDates":[{"endDate":"2024-09-26T00:00:00+00:00","startDate":"2021-09-27T00:00:00+00:00","startDateDateOnly":"2021-09-27","endDateDateOnly":"2024-09-26"}],"amountAwarded":95373,"Financial Year":"2020/21","Lead Applicant":"Mx Arthur Davis","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Davis","Partnership Value":95373,"Approval Committee":"ERG11 Social Science and Bioethics, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London","addressCountry":"United Kingdom","id_and_name":"[\"University College London\", \"360G-Wellcome-ORG:University-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Temporalities in Tension: Rethinking Healthcare Provisions for Sexual Migrants This work responds to a growing volume of research on the wellbeing of sexual migrants. Little attention has been paid to defining migration in this literature, which is often understood in a purely spatial sense. In this project, I claim that sexual migrants \u2013 whether from the UK or abroad \u2013 traverse temporal, as well as spatial, boundaries. This, I claim, has important implications for sexual wellbeing and risk. Through ethnographic research in a London sexual health clinic, including two sets of 15 semi-structured interviews with service users and ten interviews with clinic staff, I seek to uncover the extent to which abrupt shifts between timelines, such as coming out of the closet, transitioning, or moving to radically new environments such as halls of residence or retirement homes, contribute to sexual risk. This research will problematise racist and imperialist geographies of risk that locate risk in faraway lands, while also bringing to light corrective measures that will improve patient experiences and health outcomes of temporal migrants, from wherever they originate. These measures include a recalibration of eligibility criteria for targeted risk reduction interventions and an identification of further training needs for sexual health staff working with temporal migrants.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223403_Z_21_Z","title":"Exploring \u2018the domestic\u2019 in contemporary hospice architecture: a critical examination of the architecture and design of in-patient palliative care facilities in England","Region":"Yorkshire and the Humber","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Graham Ferrier","Internal ID":"223403/Z/21/Z","description":"This project proposes a new critical study of English hospice architecture, aimed at making evidence-based recommendations for inclusive hospice design. Although 40 million people need palliative care worldwide annually, relatively little research has examined the settings in which palliative care is administered or attempted to understand how patients, visitors and staff experience them. The widespread tendency in contemporary hospice architecture to make palliative care settings resemble domestic residences is rarely interrogated, despite potential problems surrounding the home\u2019s complexity and the question of whose home is being imitated. A better understanding of hospice architecture is needed to establish how to design hospices inclusively for individuals from all socio-economic and cultural backgrounds, especially given documented disadvantage in access for some groups.\n\nThis project will employ an interdisciplinary methodology, examining English palliative care facilities through site visits and analysis of primary documents, and exploring how individuals experience these environments through ethnographic field work, including observation, interviews and focus groups.\n\nThis study will provide a novel examination of English hospice architecture, highlighting the voices of the users of palliative care settings. Findings will be synthesised into recommendations for policy makers on how to address the issue of domestic design inclusively in palliative care settings.\n","plannedDates":[{"endDate":"2024-09-19T00:00:00+00:00","startDate":"2021-09-20T00:00:00+00:00","startDateDateOnly":"2021-09-20","endDateDateOnly":"2024-09-19"}],"amountAwarded":106241,"Financial Year":"2020/21","Lead Applicant":"Ms Lucia Crowther","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Crowther","Partnership Value":106241,"Approval Committee":"ERG10 Medical Humanities, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Hull","name":"University of Hull","addressCountry":"United Kingdom","id_and_name":"[\"University of Hull\", \"360G-Wellcome-ORG:University-of-Hull\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Hull","name":"University of Hull"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Exploring \u2018the domestic\u2019 in contemporary hospice architecture: a critical examination of the architecture and design of in-patient palliative care facilities in England This project proposes a new critical study of English hospice architecture, aimed at making evidence-based recommendations for inclusive hospice design. Although 40 million people need palliative care worldwide annually, relatively little research has examined the settings in which palliative care is administered or attempted to understand how patients, visitors and staff experience them. The widespread tendency in contemporary hospice architecture to make palliative care settings resemble domestic residences is rarely interrogated, despite potential problems surrounding the home\u2019s complexity and the question of whose home is being imitated. A better understanding of hospice architecture is needed to establish how to design hospices inclusively for individuals from all socio-economic and cultural backgrounds, especially given documented disadvantage in access for some groups.\n\nThis project will employ an interdisciplinary methodology, examining English palliative care facilities through site visits and analysis of primary documents, and exploring how individuals experience these environments through ethnographic field work, including observation, interviews and focus groups.\n\nThis study will provide a novel examination of English hospice architecture, highlighting the voices of the users of palliative care settings. Findings will be synthesised into recommendations for policy makers on how to address the issue of domestic design inclusively in palliative care settings.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223402_Z_21_Z","title":"The Progress Paradox: Exploring the nexus between development, social inequalities, and mental distress in northern Pakistan","Region":"Scotland","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Linda McKie","Internal ID":"223402/Z/21/Z","description":"Mental health activists and service-users have long argued for research and interventions to take into consideration structural determinants of mental distress such as violence and inequality. Yet, current scholarship on high rates of mental distress amongst women in Pakistan focus on proximal social determinants (factors pertaining to individuals and families).\n\n \n\nThis project challenges public health investigations that places responsibility of poor mental health of women in the region on family conflict, thereby misplacing causal accountability and missing the opportunity for large-scale transformation and social change. Taking poor mental health amongst women in northern Pakistan as a case study, this project examines how structural determinants such as gender inequality, poverty, and impact of development interventions, shape women\u2019s mental health in northern Pakistan. The proposed research will comprise of in-depth interviews, participant observation and archival research in Gilgit Baltistan, where high rates of suicides/attempted suicides have been recorded.\n\n \n\nThe project draws on critical perspectives from the fields of global mental health, international development, and gender studies. It aims to provide evidence and insights to researchers, mental health service providers, advocates, and policymakers in delivering health and gender justice through informed interventions and policies in Pakistan, and more broadly, South Asia.\n","plannedDates":[{"endDate":"2024-08-30T00:00:00+00:00","startDate":"2021-07-01T00:00:00+00:00","startDateDateOnly":"2021-07-01","endDateDateOnly":"2024-08-30"}],"amountAwarded":110278,"Financial Year":"2020/21","Lead Applicant":"Ms Laila Rajani","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Rajani","Partnership Value":110278,"Approval Committee":"ERG11 Social Science and Bioethics, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Edinburgh","name":"University of Edinburgh","addressCountry":"United Kingdom","id_and_name":"[\"University of Edinburgh\", \"360G-Wellcome-ORG:University-of-Edinburgh\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Edinburgh","name":"University of Edinburgh"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"The Progress Paradox: Exploring the nexus between development, social inequalities, and mental distress in northern Pakistan Mental health activists and service-users have long argued for research and interventions to take into consideration structural determinants of mental distress such as violence and inequality. Yet, current scholarship on high rates of mental distress amongst women in Pakistan focus on proximal social determinants (factors pertaining to individuals and families).\n\n \n\nThis project challenges public health investigations that places responsibility of poor mental health of women in the region on family conflict, thereby misplacing causal accountability and missing the opportunity for large-scale transformation and social change. Taking poor mental health amongst women in northern Pakistan as a case study, this project examines how structural determinants such as gender inequality, poverty, and impact of development interventions, shape women\u2019s mental health in northern Pakistan. The proposed research will comprise of in-depth interviews, participant observation and archival research in Gilgit Baltistan, where high rates of suicides/attempted suicides have been recorded.\n\n \n\nThe project draws on critical perspectives from the fields of global mental health, international development, and gender studies. It aims to provide evidence and insights to researchers, mental health service providers, advocates, and policymakers in delivering health and gender justice through informed interventions and policies in Pakistan, and more broadly, South Asia.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223377_Z_21_Z","title":"Embodied Inequalities of the Anthropocene. 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From this research and in conjunction with open access publisher UCL Press, we will develop a tri-lingual digital resource for teaching and public reference.\n\nOur collaboration will begin online with bi-monthly meetings followed in February 2022 by a three day virtual cross-disciplinary seminar with invited expertise in science, geography, politics and history. We will work collaboratively to examine how these disciplines can inform Medical Anthropology of the Anthropocene and to identify articulations with policy and practice as these impact on human and environmental wellbeing. In November 2022 we will hold a face-to-face workshop in Mexico to develop dissemination and publications including the digital teaching resource and a multilingual special edition of a Latin American Medical Anthropology journal.\n","plannedDates":[{"endDate":"2023-09-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00","startDateDateOnly":"2021-10-01","endDateDateOnly":"2023-09-30"}],"amountAwarded":201912,"Financial Year":"2020/21","Lead Applicant":"Dr Sahra Gibbon","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"Gibbon","Partnership Value":201912,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London","addressCountry":"United Kingdom","id_and_name":"[\"University College London\", \"360G-Wellcome-ORG:University-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Embodied Inequalities of the Anthropocene. Building Capacity in Medical Anthropology This collaboration between Brazil, Mexico and the UK brings together environmental, indigenous, biosocial, multispecies, gender and theoretical expertise in Medical Anthropology, to extend interdisciplinary engagement concerning how the Anthropocene epoch impacts on human health. Supported by a post-doctoral researcher in each of the collaborating centres, we will develop Medical Anthropology in four areas: i) indigenous experience and coloniality of the Anthropocene, ii) gender, reproduction and environmental justice, iii) multispecies ethnography and human-animal health, iv) COVID-19 and public understanding of the Anthropocene. From this research and in conjunction with open access publisher UCL Press, we will develop a tri-lingual digital resource for teaching and public reference.\n\nOur collaboration will begin online with bi-monthly meetings followed in February 2022 by a three day virtual cross-disciplinary seminar with invited expertise in science, geography, politics and history. We will work collaboratively to examine how these disciplines can inform Medical Anthropology of the Anthropocene and to identify articulations with policy and practice as these impact on human and environmental wellbeing. In November 2022 we will hold a face-to-face workshop in Mexico to develop dissemination and publications including the digital teaching resource and a multilingual special edition of a Latin American Medical Anthropology journal.\n","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223350_Z_21_Z","title":"Humour and polemic in UK disability arts and its institutions, 1976-2010","Region":"Greater London","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof L Nead","Internal ID":"223350/Z/21/Z","description":"This practice-led project, from a disabled artist-researcher, investigates humour as a form of activism within the UK Disability Arts Movement. Focusing on the under-researched National Disability Arts Collection and Archives, it will document the emergence and uses of critical or polemical humour between 1976 and 2010. This archival research, supported by conversations with the movement\u2019s artists, will combine object-orientated creative practice and sensory enthnography with historiographical research.\n\nArt history has neglected these artists, who created institutions essential to UK arts today. Overlooked by disability studies too, their transgressive humour critically engaged with changing ideas of disability. For the medical humanities, the research will create new knowledge of how disabled people have driven and understood changing ideas of disability. For critical medical humanities, this project will offer a new paradigm of disability arts research, specifically addressing the significance of the disabled artist-subject as researcher. \n\nAt a time when the experience of disability in the UK is increasingly individualised, understanding this humour\u2019s agency, collectivity and its effectiveness in disability activism is urgent. This study will inform arts policy, re-position disability activism within art history, and inform critical understanding of how ideas of disability are influenced and understood by disabled people.\n","plannedDates":[{"endDate":"2024-09-04T00:00:00+00:00","startDate":"2021-09-05T00:00:00+00:00","startDateDateOnly":"2021-09-05","endDateDateOnly":"2024-09-04"}],"amountAwarded":89482,"Financial Year":"2020/21","Lead Applicant":"Ms Laura Cowley","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Cowley","Partnership Value":89482,"Approval Committee":"ERG10 Medical Humanities, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Birkbeck-University-of-London","name":"Birkbeck University of London","addressCountry":"United Kingdom","id_and_name":"[\"Birkbeck University of London\", \"360G-Wellcome-ORG:Birkbeck-University-of-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Birkbeck-University-of-London","name":"Birkbeck University of London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Humour and polemic in UK disability arts and its institutions, 1976-2010 This practice-led project, from a disabled artist-researcher, investigates humour as a form of activism within the UK Disability Arts Movement. Focusing on the under-researched National Disability Arts Collection and Archives, it will document the emergence and uses of critical or polemical humour between 1976 and 2010. This archival research, supported by conversations with the movement\u2019s artists, will combine object-orientated creative practice and sensory enthnography with historiographical research.\n\nArt history has neglected these artists, who created institutions essential to UK arts today. Overlooked by disability studies too, their transgressive humour critically engaged with changing ideas of disability. For the medical humanities, the research will create new knowledge of how disabled people have driven and understood changing ideas of disability. For critical medical humanities, this project will offer a new paradigm of disability arts research, specifically addressing the significance of the disabled artist-subject as researcher. \n\nAt a time when the experience of disability in the UK is increasingly individualised, understanding this humour\u2019s agency, collectivity and its effectiveness in disability activism is urgent. This study will inform arts policy, re-position disability activism within art history, and inform critical understanding of how ideas of disability are influenced and understood by disabled people.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223328_Z_21_Z","title":"The Beaumont Society: Trans Cultures, Identities and Everyday Subjectivities, 1966-2004 ","Region":"Greater London","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Matt Cook","Internal ID":"223328/Z/21/Z","description":"This project will be the first comprehensive history of the Beaumont Society, a UK based trans support network. It will focus on the ways that members of the Society conceptualised their sense of self, both within the organisation and in relation to other trans and cis gender people and cultures. This research will be much more than a history of the society itself but will make significant strides in historicising trans identities and experiences in the UK, exploring the ways trans people negotiated the medical and health discourse that have historically legitimised trans identity, alongside other ways of understanding gender crossing in their everyday lives. These perspectives will in addition allow for reconsideration of wider themes of belonging and selfhood and the changing nature of social movements from the 1960s to the early years of the internet. Using a combination of archival research and oral history the project will be organised thematically, examining trans subjectivities through the everyday including domestic life, work, clubs and leisure, and other countercultural and political movements. The relationship of trans identities and experience to shifting gender norms will be a cross cutting theme. \n","plannedDates":[{"endDate":"2024-09-30T00:00:00+00:00","startDate":"2021-10-01T00:00:00+00:00","startDateDateOnly":"2021-10-01","endDateDateOnly":"2024-09-30"}],"amountAwarded":87362,"Financial Year":"2020/21","Lead Applicant":"Ms Leila Sellers","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Sellers","Partnership Value":87362,"Approval Committee":"ERG10 Medical Humanities, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Birkbeck-University-of-London","name":"Birkbeck University of London","addressCountry":"United Kingdom","id_and_name":"[\"Birkbeck University of London\", \"360G-Wellcome-ORG:Birkbeck-University-of-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Birkbeck-University-of-London","name":"Birkbeck University of London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"The Beaumont Society: Trans Cultures, Identities and Everyday Subjectivities, 1966-2004 This project will be the first comprehensive history of the Beaumont Society, a UK based trans support network. It will focus on the ways that members of the Society conceptualised their sense of self, both within the organisation and in relation to other trans and cis gender people and cultures. This research will be much more than a history of the society itself but will make significant strides in historicising trans identities and experiences in the UK, exploring the ways trans people negotiated the medical and health discourse that have historically legitimised trans identity, alongside other ways of understanding gender crossing in their everyday lives. These perspectives will in addition allow for reconsideration of wider themes of belonging and selfhood and the changing nature of social movements from the 1960s to the early years of the internet. Using a combination of archival research and oral history the project will be organised thematically, examining trans subjectivities through the everyday including domestic life, work, clubs and leisure, and other countercultural and political movements. The relationship of trans identities and experience to shifting gender norms will be a cross cutting theme. \n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223327_Z_21_Z","title":"Zoonotic divergences: humans, rats and micro-organisms in Guarani-Mbya villages of Jaragu\u00e1 Indigenous Land (S\u00e3o Paulo/SP, Brazil)","Region":"Scotland","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Dr Paloma Gay y Blasco","Internal ID":"223327/Z/21/Z","description":"My PhD research aims to deepen anthropological understandings of health, illness and disease in contexts where the Guarani-Mbya people, rodents and microorganisms become entangled through leptospirosis within the Jaragua´ Indigenous Land \u2013 a small territory surrounded by the city of Sa~o Paulo, Brazil\u2019s largest metropolis. My project will be based on the ethnographic study of multispecies relations entangling indigenous people, Leptospira spp bacteria, governmental agencies of disease and rodent control, and health professionals. The project will focus on the examination of Guarani-Mbya perceptions of and practices around rodent-borne infection so as to unsettle the colonial vestiges of epidemiological reasoning that continues to inform understandings of zoonosis. This investigation of human-rodent relations will be path-breaking for Amerindian Studies, as, for the most part, these have focused on animal-human relations primarily in contexts of hunting and pet-keeping. The ethnographic data produced by the project will also be useful for reconceptualizing and developing rodent-management strategies and community-led programmes in other Amerindian contexts, contributing to critically expanding the One Health initiative towards an ethnographic-based, decolonized, community-led, and multispecies approach. [zoonosis, Amerindian Studies, rats, Guarani-Mbya, Brazil]\n","plannedDates":[{"endDate":"2024-08-31T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00","startDateDateOnly":"2021-09-01","endDateDateOnly":"2024-08-31"}],"amountAwarded":131210,"Financial Year":"2020/21","Lead Applicant":"Mr Bruno Santos","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Santos","Partnership Value":131210,"Approval Committee":"ERG11 Social Science and Bioethics, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-St-Andrews","name":"University of St Andrews","addressCountry":"United Kingdom","id_and_name":"[\"University of St Andrews\", \"360G-Wellcome-ORG:University-of-St-Andrews\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-St-Andrews","name":"University of St Andrews"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Zoonotic divergences: humans, rats and micro-organisms in Guarani-Mbya villages of Jaragu\u00e1 Indigenous Land (S\u00e3o Paulo/SP, Brazil) My PhD research aims to deepen anthropological understandings of health, illness and disease in contexts where the Guarani-Mbya people, rodents and microorganisms become entangled through leptospirosis within the Jaragua´ Indigenous Land \u2013 a small territory surrounded by the city of Sa~o Paulo, Brazil\u2019s largest metropolis. My project will be based on the ethnographic study of multispecies relations entangling indigenous people, Leptospira spp bacteria, governmental agencies of disease and rodent control, and health professionals. The project will focus on the examination of Guarani-Mbya perceptions of and practices around rodent-borne infection so as to unsettle the colonial vestiges of epidemiological reasoning that continues to inform understandings of zoonosis. This investigation of human-rodent relations will be path-breaking for Amerindian Studies, as, for the most part, these have focused on animal-human relations primarily in contexts of hunting and pet-keeping. The ethnographic data produced by the project will also be useful for reconceptualizing and developing rodent-management strategies and community-led programmes in other Amerindian contexts, contributing to critically expanding the One Health initiative towards an ethnographic-based, decolonized, community-led, and multispecies approach. [zoonosis, Amerindian Studies, rats, Guarani-Mbya, Brazil]\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223322_Z_21_Z","title":"Transnationalism and Changing Medical Practice Paradigms in Exile Tibetan Medicine and the West ","Region":"Scotland","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Linda McKie","Internal ID":"223322/Z/21/Z","description":"Transnational medical practice is a common phenomenon in contemporary Tibetan medicine, especially among exile practitioners in India and Nepal. Both in the form of medical tours abroad or local treatments of foreign patients and via telemedicine, doctors provide transnational medical care. However, as a result of the deterritorialization of practice and practitioners or new phenomena like telemedicine and innovations in medical treatment options, varying degrees of changes in contrast to national treatment paradigms occur that raise questions about the efficacy or benefit for patients. This research seeks to explore and analyse transnational Tibetan medical practice and asks to what extent this trend transforms essential principles, perceptions, and representations of Tibetan medicine. The aim is to determine and question tendencies towards a modern or global Tibetan medicine, following Wujastyk and Smith's categories of modern and global Ayurveda. Using the methods of participant observation and semi-structured interviews with Tibetan medical doctors and patients, I will conduct a 13 months long multi-sited ethnographic fieldwork in India, Nepal, and Europe. Ultimately, the research will help to understand the challenges to and possibilities for globalised medical practice, contributing to the growing anthropological interest in global health.\n\nKeywords: Tibetan medicine, transnational medical practice, therapeutic travel, telemedicine\n","plannedDates":[{"endDate":"2024-08-31T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00","startDateDateOnly":"2021-09-01","endDateDateOnly":"2024-08-31"}],"amountAwarded":133183,"Financial Year":"2020/21","Lead Applicant":"Miss Patricia Mundelius","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Mundelius","Partnership Value":133183,"Approval Committee":"ERG11 Social Science and Bioethics, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Edinburgh","name":"University of Edinburgh","addressCountry":"United Kingdom","id_and_name":"[\"University of Edinburgh\", \"360G-Wellcome-ORG:University-of-Edinburgh\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Edinburgh","name":"University of Edinburgh"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Transnationalism and Changing Medical Practice Paradigms in Exile Tibetan Medicine and the West Transnational medical practice is a common phenomenon in contemporary Tibetan medicine, especially among exile practitioners in India and Nepal. Both in the form of medical tours abroad or local treatments of foreign patients and via telemedicine, doctors provide transnational medical care. However, as a result of the deterritorialization of practice and practitioners or new phenomena like telemedicine and innovations in medical treatment options, varying degrees of changes in contrast to national treatment paradigms occur that raise questions about the efficacy or benefit for patients. This research seeks to explore and analyse transnational Tibetan medical practice and asks to what extent this trend transforms essential principles, perceptions, and representations of Tibetan medicine. The aim is to determine and question tendencies towards a modern or global Tibetan medicine, following Wujastyk and Smith's categories of modern and global Ayurveda. Using the methods of participant observation and semi-structured interviews with Tibetan medical doctors and patients, I will conduct a 13 months long multi-sited ethnographic fieldwork in India, Nepal, and Europe. Ultimately, the research will help to understand the challenges to and possibilities for globalised medical practice, contributing to the growing anthropological interest in global health.\n\nKeywords: Tibetan medicine, transnational medical practice, therapeutic travel, telemedicine\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223312_Z_21_Z","title":"Medicine, charm or treasure? Mediterranean red coral in England c.1600-1750.","Region":"South East","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Catherine Richardson","Internal ID":"223312/Z/21/Z","description":"Mediterranean red coral has long been treasured around the world and is currently under threat from intensive fishing, oil drilling and rising sea temperatures caused by climate change. This project will explore the value placed on Mediterranean red coral, Corallium rubrum, a natural material sourced and prized in medieval and Renaissance Italy but also a culturally significant foreign import to Protestant England c.1600-1750. While coral is highly visible in early modern English sources, the historical importance of coral to English beliefs about physical and mental health is yet to be analysed. Drawing on a wealth of documentary evidence, material and visual culture, held in The National Archives, V & A, British Museum, Wellcome Collection, Science Museum and National Portrait Gallery, I will examine how coral was used as a medicinal ingredient, contributed to a domestic armoury against natural and supernatural threats, and was also a luxury commodity, perceived to be a material imbued with particular values, properties and powers in English society. Once considered to be a limitless natural treasure of the seas, the ecological threat to red coral in the Mediterranean makes understanding our long history of engagement with this precious species all the more critical at this time.\n","plannedDates":[{"endDate":"2024-08-31T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00","startDateDateOnly":"2021-09-01","endDateDateOnly":"2024-08-31"}],"amountAwarded":86903,"Financial Year":"2020/21","Lead Applicant":"Ms Francesca Richards","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Richards","Partnership Value":86903,"Approval Committee":"ERG10 Medical Humanities, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Kent","name":"University of Kent","addressCountry":"United Kingdom","id_and_name":"[\"University of Kent\", \"360G-Wellcome-ORG:University-of-Kent\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Kent","name":"University of Kent"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Medicine, charm or treasure? Mediterranean red coral in England c.1600-1750. Mediterranean red coral has long been treasured around the world and is currently under threat from intensive fishing, oil drilling and rising sea temperatures caused by climate change. This project will explore the value placed on Mediterranean red coral, Corallium rubrum, a natural material sourced and prized in medieval and Renaissance Italy but also a culturally significant foreign import to Protestant England c.1600-1750. While coral is highly visible in early modern English sources, the historical importance of coral to English beliefs about physical and mental health is yet to be analysed. Drawing on a wealth of documentary evidence, material and visual culture, held in The National Archives, V & A, British Museum, Wellcome Collection, Science Museum and National Portrait Gallery, I will examine how coral was used as a medicinal ingredient, contributed to a domestic armoury against natural and supernatural threats, and was also a luxury commodity, perceived to be a material imbued with particular values, properties and powers in English society. Once considered to be a limitless natural treasure of the seas, the ecological threat to red coral in the Mediterranean makes understanding our long history of engagement with this precious species all the more critical at this time.\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223294_Z_21_Z","title":"Skeleton Merchants as Agents of Socio-Scientific Advancements: Exploring the History of Bone Trade in Colonial and Postcolonial India, 1858\u20131985 ","Region":"South East","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Dr Erica Charters","Internal ID":"223294/Z/21/Z","description":"My dissertation seeks to argue that the modern Western Scientific advancement was largely predicated on the supply of South Asian bones from India to Britain during the legal creation of the British Raj in 1858. In doing so, it attempts to link the trade of bones and bodies to what I call the \u2018Red Industry\u2019\u2014a full-fledged socio-economic establishment employing numerous labourers, specialized in different units, which thereby assumed a pivotal place in the network of imperial capitalism, propelled by profit. Besides leading to the emergence of ancillary industries, wherein bones are seen as potentially esoteric, aesthetic and even agricultural resources, I argue that the \u2018Red market\u2019 also projected itself as indispensable with regards to the contributions in various socio-medical fields: forensic anthropology, phrenological works, osteo-archaeological discoveries and leading studies on Osteoporosis. Focusing primarily on the local perceptions of the dead, and the surrounding inter and intra-caste polemics on dissection, the work essentially seeks to bridge the long-standing gap between the trade economy and the overarching historical debates predominantly concerning bio-ethics and public health, while interacting with law, labour, society and medicine throughout the mid-nineteenth to the late twentieth centuries\u2014the era of decolonization. \n\nKeywords:\n\nBritish Raj, South Asia, Public Health, Medicine\n","plannedDates":[{"endDate":"2024-09-30T00:00:00+00:00","startDate":"2021-07-01T00:00:00+00:00","startDateDateOnly":"2021-07-01","endDateDateOnly":"2024-09-30"}],"amountAwarded":171260,"Financial Year":"2020/21","Lead Applicant":"Miss Nilanjana Dutta","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Dutta","Partnership Value":171260,"Approval Committee":"ERG10 Medical Humanities, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Skeleton Merchants as Agents of Socio-Scientific Advancements: Exploring the History of Bone Trade in Colonial and Postcolonial India, 1858\u20131985 My dissertation seeks to argue that the modern Western Scientific advancement was largely predicated on the supply of South Asian bones from India to Britain during the legal creation of the British Raj in 1858. In doing so, it attempts to link the trade of bones and bodies to what I call the \u2018Red Industry\u2019\u2014a full-fledged socio-economic establishment employing numerous labourers, specialized in different units, which thereby assumed a pivotal place in the network of imperial capitalism, propelled by profit. Besides leading to the emergence of ancillary industries, wherein bones are seen as potentially esoteric, aesthetic and even agricultural resources, I argue that the \u2018Red market\u2019 also projected itself as indispensable with regards to the contributions in various socio-medical fields: forensic anthropology, phrenological works, osteo-archaeological discoveries and leading studies on Osteoporosis. Focusing primarily on the local perceptions of the dead, and the surrounding inter and intra-caste polemics on dissection, the work essentially seeks to bridge the long-standing gap between the trade economy and the overarching historical debates predominantly concerning bio-ethics and public health, while interacting with law, labour, society and medicine throughout the mid-nineteenth to the late twentieth centuries\u2014the era of decolonization. \n\nKeywords:\n\nBritish Raj, South Asia, Public Health, Medicine\n","awardDateDateOnly":"2021-05-11","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223290_Z_21_Z","title":"Bioethics Research: Interdisciplinary Group of Early Career Researchers: Bristol-Kyoto-Yonsei (BRIDGES:BKY)","Region":"South West","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223290/Z/21/Z","description":"Building on a developing track record of collaboration between Bristol, Kyoto and Yonsei, BRIDGES:BKY aims to address shared bioethical challenges, through sharing learning and expertise, to benefit postgraduate and early career researchers (PGR/ECRs). Our four challenge areas are: (1) ageing and end-of-life care; (2) clinical ethics support; (3) reproduction and genomics; and (4) theories and approaches in bioethics. These are shared (indeed, global) challenges, which invite new research, and in which the partners have complementary research interests. Guided by these challenges, BRIDGES:BKY will share learning and expertise, including on different methodological approaches to research in these areas. BRIDGES:BKY will leverage our existing links and partnerships to deliver new opportunities to PGR/ECR participants, drawn from across the partner institutions (and beyond), to participate in, and benefit from training workshops, conferences and a (virtual) visiting researcher scheme. Supported by teleconferencing and a dedicated website, activities will be virtual, with some in-person elements (where appropriate). All partners will host and contribute to these activities, through which PGR/ECR participants will develop their knowledge and skills, and their - and the partners\u2019 - future collaborative research endeavours will be shaped. \n","plannedDates":[{"endDate":"2023-08-31T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00","startDateDateOnly":"2021-09-01","endDateDateOnly":"2023-08-31"}],"amountAwarded":201781,"Financial Year":"2020/21","Lead Applicant":"Prof Richard Huxtable","grantProgramme":[{"title":"Discretionary Award \u2013 C&S","title_keyword":"Discretionary Award \u2013 C&S"}],"Applicant Surname":"Huxtable","Partnership Value":201781,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Bristol","name":"University of Bristol","addressCountry":"United Kingdom","id_and_name":"[\"University of Bristol\", \"360G-Wellcome-ORG:University-of-Bristol\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Bristol","name":"University of Bristol"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Bioethics Research: Interdisciplinary Group of Early Career Researchers: Bristol-Kyoto-Yonsei (BRIDGES:BKY) Building on a developing track record of collaboration between Bristol, Kyoto and Yonsei, BRIDGES:BKY aims to address shared bioethical challenges, through sharing learning and expertise, to benefit postgraduate and early career researchers (PGR/ECRs). Our four challenge areas are: (1) ageing and end-of-life care; (2) clinical ethics support; (3) reproduction and genomics; and (4) theories and approaches in bioethics. These are shared (indeed, global) challenges, which invite new research, and in which the partners have complementary research interests. Guided by these challenges, BRIDGES:BKY will share learning and expertise, including on different methodological approaches to research in these areas. BRIDGES:BKY will leverage our existing links and partnerships to deliver new opportunities to PGR/ECR participants, drawn from across the partner institutions (and beyond), to participate in, and benefit from training workshops, conferences and a (virtual) visiting researcher scheme. Supported by teleconferencing and a dedicated website, activities will be virtual, with some in-person elements (where appropriate). All partners will host and contribute to these activities, through which PGR/ECR participants will develop their knowledge and skills, and their - and the partners\u2019 - future collaborative research endeavours will be shaped. \n","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223287_Z_21_Z","title":"Health Professional Responses to Deathbed Phenomena: Implications for medical knowledge and care","Region":"Greater London","currency":"GBP","awardDate":"2021-05-11T00:00:00+00:00","Sponsor(s)":"Prof Monica Greco","Internal ID":"223287/Z/21/Z","description":"Meaningful dreams, visions and coincidences are a remarkably common feature of the dying process. While patients and families report their profound spiritual significance, mainstream clinical literature explains them in materialist terms. This project asks how health professionals respond to such events on the ground, whether they reflect this materialist approach or if there are examples of healthworkers engaging in more ontologically and epistemologically open ways. The research will explore how philosophical responses influence the day-to-day practices of care. It will also ask whether variation in interpretations of such events runs along existing lines of social or cultural difference among both healthworkers and patients. I will take a methodologically interdisciplinary approach combining an ethnography of a hospice in-patient unit (utilising my experience as a palliative care nurse) with narrative interviews of staff who have responded to deathbed experiences. Drawing on feminist care theory, science and technology studies and the medical humanities this study will explore the significance of responses to deathbed phenomena for both clinical knowledge practices and patient care. \n","plannedDates":[{"endDate":"2027-10-03T00:00:00+00:00","startDate":"2021-10-04T00:00:00+00:00","startDateDateOnly":"2021-10-04","endDateDateOnly":"2027-10-03"}],"amountAwarded":94754,"Financial Year":"2020/21","Lead Applicant":"Ms Rachel Cummings","grantProgramme":[{"title":"PhD Studentship in H&SS","title_keyword":"PhD Studentship in H&SS"}],"Applicant Surname":"Cummings","Partnership Value":94754,"Approval Committee":"ERG10 Medical Humanities, Early Career Awards","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Goldsmiths-University-of-London","name":"Goldsmiths, University of London","addressCountry":"United Kingdom","id_and_name":"[\"Goldsmiths, University of London\", \"360G-Wellcome-ORG:Goldsmiths-University-of-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Goldsmiths-University-of-London","name":"Goldsmiths, University of London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Health Professional Responses to Deathbed Phenomena: Implications for medical knowledge and care Meaningful dreams, visions and coincidences are a remarkably common feature of the dying process. 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Specific aims include the development of an open access, online modular global learning programme on SARS-CoV-2 sequencing and analysis, allowing users to follow pathways of learning according to professional expertise (laboratory scientist, clinical practitioner, data scientist & epidemiologist, bioinformatician or policy maker); and the development of train-the-trainer courses in collaboration with the Wellcome Connecting Science Advanced Courses, Wellcome Africa and Asia Programmes, and other contributors.\n","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223271_A_21_Z","title":" Leveraging COG-UK expertise to support the global dissemination of SARS-CoV-2 genome sequencing","Region":"East of England","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223271/A/21/Z","description":"Control of the COVID-19 pandemic depends on the development and equitable roll-out of vaccines that remain effective over time. 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Through a variety of policies and initiatives, there is renewed momentum for sharing research outputs as part of a more connected and collaborative open research ecosystem. However, there remains a need for consensus around how best to deliver a research dissemination system that maximises the benefits for both science and society, and the researchers upon which such a system depends.\n\nOpen Research Central (ORC) is a not-for-profit organization that aims to change the paradigm for primary research dissemination by bringing together key representatives across the scholarly ecosystem to define standards, build a movement to expand adoption of these standards, encourage the community to provide researchers with services that meet these standards and promote these standards.\n\nTo build further momentum and adoption globally of open research publishing approaches, the ORC Board wish to secure resource for 18 months to underpin more significant fund raising efforts to enable ORC to deliver on its mission, to develop and start to put into place a sustainability plan, and to support the Board in the day-to-day running and management of ORC.\n","plannedDates":[{"endDate":"2022-11-30T00:00:00+00:00","startDate":"2021-06-01T00:00:00+00:00","startDateDateOnly":"2021-06-01","endDateDateOnly":"2022-11-30"}],"amountAwarded":16000,"Financial Year":"2020/21","Lead Applicant":"Dr Rebecca Lawrence","grantProgramme":[{"title":"Discretionary Award - Open research","title_keyword":"Discretionary Award - Open research"}],"Applicant Surname":"Lawrence","Partnership Value":16000,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Open-Research-Central","name":"Open Research Central","addressCountry":"United Kingdom","id_and_name":"[\"Open Research Central\", \"360G-Wellcome-ORG:Open-Research-Central\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Open-Research-Central","name":"Open Research Central"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Open Research Central The open access movement has demonstrated that \"openness\" is a benefit to the creation, dissemination, and reuse of knowledge. Through a variety of policies and initiatives, there is renewed momentum for sharing research outputs as part of a more connected and collaborative open research ecosystem. However, there remains a need for consensus around how best to deliver a research dissemination system that maximises the benefits for both science and society, and the researchers upon which such a system depends.\n\nOpen Research Central (ORC) is a not-for-profit organization that aims to change the paradigm for primary research dissemination by bringing together key representatives across the scholarly ecosystem to define standards, build a movement to expand adoption of these standards, encourage the community to provide researchers with services that meet these standards and promote these standards.\n\nTo build further momentum and adoption globally of open research publishing approaches, the ORC Board wish to secure resource for 18 months to underpin more significant fund raising efforts to enable ORC to deliver on its mission, to develop and start to put into place a sustainability plan, and to support the Board in the day-to-day running and management of ORC.\n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223080_Z_21_Z","title":"Advancing the global health agenda with the Paris Peace Forum","Region":"International","currency":"GBP","awardDate":"2021-04-30T00:00:00+00:00","Internal ID":"223080/Z/21/Z","description":"The Paris Peace Forum will host a series of discussions to maintain the partnership developed by ACT-A (Access to COVID-19 Tools Accelerator) and the governance of global health at the top of the political agenda and further deliver concrete solutions while contributing to the construction of an overall governance framework in the sector. The proposal includes hosting discussions taking place in the framework of a pilot, year-long partnership between the Forum and Wellcome Trust. These discussions would mobilize stakeholders of the Forum\u2019s community and beyond. The Forum would naturally seek Wellcome\u2019s guidance and advice on the scope, topics, invitees, and outputs of these discussions. Stakeholders would be invited to participate in each discussion based on their institutional focus and expertise and on the basis of their capacity to contribute to and implement the desired outcomes. With the support provided by the Wellcome Trust, the Forum could convene two roundtables in 2021, to provide for sufficient time for preparation, eventually for follow-up actions in between and potentially to leverage to key moments in the annual Forum cycle: the Spring meetings of the Paris Peace Forum (May 2021) and the fourth edition of the annual event (11-13 November, 2021).\n","plannedDates":[{"endDate":"2022-04-20T00:00:00+00:00","startDate":"2021-04-21T00:00:00+00:00","startDateDateOnly":"2021-04-21","endDateDateOnly":"2022-04-20"}],"amountAwarded":85186,"Financial Year":"2020/21","Lead Applicant":"Mr Adrien Abecassis","grantProgramme":[{"title":"Discretionary Award - Policy ","title_keyword":"Discretionary Award - Policy "}],"Applicant Surname":"Abecassis","Partnership Value":85186,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Paris-Peace-Forum","name":"Paris Peace Forum","addressCountry":"France","id_and_name":"[\"Paris Peace Forum\", \"360G-Wellcome-ORG:Paris-Peace-Forum\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Paris-Peace-Forum","name":"Paris Peace Forum"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Advancing the global health agenda with the Paris Peace Forum The Paris Peace Forum will host a series of discussions to maintain the partnership developed by ACT-A (Access to COVID-19 Tools Accelerator) and the governance of global health at the top of the political agenda and further deliver concrete solutions while contributing to the construction of an overall governance framework in the sector. The proposal includes hosting discussions taking place in the framework of a pilot, year-long partnership between the Forum and Wellcome Trust. These discussions would mobilize stakeholders of the Forum\u2019s community and beyond. The Forum would naturally seek Wellcome\u2019s guidance and advice on the scope, topics, invitees, and outputs of these discussions. Stakeholders would be invited to participate in each discussion based on their institutional focus and expertise and on the basis of their capacity to contribute to and implement the desired outcomes. With the support provided by the Wellcome Trust, the Forum could convene two roundtables in 2021, to provide for sufficient time for preparation, eventually for follow-up actions in between and potentially to leverage to key moments in the annual Forum cycle: the Spring meetings of the Paris Peace Forum (May 2021) and the fourth edition of the annual event (11-13 November, 2021).\n","awardDateDateOnly":"2021-04-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223068_Z_21_Z","title":"Panel on Financing for Pandemic Prevention, Preparedness and Response","Region":"International","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"223068/Z/21/Z","description":"A new high-level panel, led by co-chairs Tharman Shanmugaratnam and Lawrence H. Summers, has been mandated by the Italian presidency of the G20 to propose reforms and other measures that will lead to more reliable and sustainable financing of pandemic prevention, preparedness, and response. To support the panel's deliberations and decision-making, CGD and Bruegel propose establishing a team to lead the analysis and content development of the proposals, with logistical, outreach, engagement, and coordination support from a secretariat at Wellcome and the US National Academies of Medicine. The team will develop a short scoping note on the economic rationale behind prioritizing public investment in prevention, preparedness, and response, an outline of the final report for discussion and feedback from the co-chairs, background analyses (on landscaping current financing and issues, existing asks and proposals; setting a financing goal and assessing its value for money; and governance, organization, and incentives), a long list of 10-15 proposals for governance reform and/or new or existing financing sources and mechanisms (with pros and cons for the panel's consideration), and a final report reflecting the panel\u2019s views and the teams\u2019 own analyses.\n","plannedDates":[{"endDate":"2021-09-30T00:00:00+00:00","startDate":"2021-02-01T00:00:00+00:00","startDateDateOnly":"2021-02-01","endDateDateOnly":"2021-09-30"}],"amountAwarded":146002,"Financial Year":"2020/21","Lead Applicant":"Ms Kendra White","grantProgramme":[{"title":"Discretionary Award - Policy ","title_keyword":"Discretionary Award - Policy "}],"Applicant Surname":"White","Partnership Value":146002,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Center-for-Global-Development","name":"Center for Global Development","addressCountry":"United States","id_and_name":"[\"Center for Global Development\", \"360G-Wellcome-ORG:Center-for-Global-Development\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Center-for-Global-Development","name":"Center for Global Development"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Panel on Financing for Pandemic Prevention, Preparedness and Response A new high-level panel, led by co-chairs Tharman Shanmugaratnam and Lawrence H. 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The team will develop a short scoping note on the economic rationale behind prioritizing public investment in prevention, preparedness, and response, an outline of the final report for discussion and feedback from the co-chairs, background analyses (on landscaping current financing and issues, existing asks and proposals; setting a financing goal and assessing its value for money; and governance, organization, and incentives), a long list of 10-15 proposals for governance reform and/or new or existing financing sources and mechanisms (with pros and cons for the panel's consideration), and a final report reflecting the panel\u2019s views and the teams\u2019 own analyses.\n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223032_Z_21_Z","title":"THE ARM RACE: HOW WE CONQUERED COVID (WORKING TITLE)","Region":"International","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"223032/Z/21/Z","description":"\"THE ARM RACE: HOW WE CONQUERED COVID\" (working title) is a documentary film that will be the dispositive chronicle of the global race to research, develop, manufacture and distribute COVID-19 vaccines in the most enormous coordinated effort ever undertaken. In this unprecedented moment in history, the film will celebrate the herculean efforts of the scientific, research and immunization community during a complex time of mistrust, vaccine hesitancy, and misinformation - when trust in science itself has come under fire.\n\nThe stories track development of vaccines, (including research built on previous work fighting outbreaks including Ebola and HIV/AIDS,) and how public health agencies from hospitals to the WHO are responding to the crisis. Our narrative goes beyond the lab, delving into the complexities of underserved populations, equitable access and inclusion. We see opportunities in additional content, leveraging existing assets, foregrounding the making of the film and our collaboration with the global public health community. This project will spark interest in science\u2019s potential to solve global health challenges by documenting the largest public health effort in human history, while also offering insights into our successes and failures to help prepare the next generation to better respond to future pandemics. \n\n\n \n","plannedDates":[{"endDate":"2021-08-07T00:00:00+00:00","startDate":"2021-02-08T00:00:00+00:00","startDateDateOnly":"2021-02-08","endDateDateOnly":"2021-08-07"}],"amountAwarded":236035,"Financial Year":"2020/21","Lead Applicant":"Ms Mira Chang","grantProgramme":[{"title":"Discretionary Award - Vaccines","title_keyword":"Discretionary Award - Vaccines"}],"Applicant Surname":"Chang","Partnership Value":236035,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Utah-Film-Center","name":"Utah Film Center","addressCountry":"United States","id_and_name":"[\"Utah Film Center\", \"360G-Wellcome-ORG:Utah-Film-Center\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Utah-Film-Center","name":"Utah Film Center"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"THE ARM RACE: HOW WE CONQUERED COVID (WORKING TITLE) \"THE ARM RACE: HOW WE CONQUERED COVID\" (working title) is a documentary film that will be the dispositive chronicle of the global race to research, develop, manufacture and distribute COVID-19 vaccines in the most enormous coordinated effort ever undertaken. In this unprecedented moment in history, the film will celebrate the herculean efforts of the scientific, research and immunization community during a complex time of mistrust, vaccine hesitancy, and misinformation - when trust in science itself has come under fire.\n\nThe stories track development of vaccines, (including research built on previous work fighting outbreaks including Ebola and HIV/AIDS,) and how public health agencies from hospitals to the WHO are responding to the crisis. Our narrative goes beyond the lab, delving into the complexities of underserved populations, equitable access and inclusion. We see opportunities in additional content, leveraging existing assets, foregrounding the making of the film and our collaboration with the global public health community. This project will spark interest in science\u2019s potential to solve global health challenges by documenting the largest public health effort in human history, while also offering insights into our successes and failures to help prepare the next generation to better respond to future pandemics. \n\n\n \n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223016_Z_21_Z","title":"Can we develop a \"cognitive vaccine\" for intrusive memories of traumatic events from working in the COVID-19 pandemic? A novel and brief intervention to support ICU staff","Region":"South East","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"223016/Z/21/Z","description":"Intensive care unit (ICU) staff face repeated exposure to traumatic work-related events and have reported high levels of posttraumatic symptoms during the pandemic. Novel, scalable and preventative interventions are required.\n\n\nWe are developing a \"cognitive vaccine\" approach for ICU staff against one key symptom \u2013 intrusive memories of traumatic events. These are unwanted, distressing and disrupt functioning.\n\nOur novel, brief gameplay intervention is repeatable, flexible, non-stigmatising, scalable, and driven by mental health science.\n\n\nThis digital intervention is guided by an initial session of psychologist support, then self-administered; delivered same day or months post-trauma, suitable for repeated trauma exposure, fits with busy lives of ICU staff, without discussing trauma detail.\n\n\nPart 1 uses a Bayesian design to optimise and co-develop procedures with ICU professionals and move at speed under pandemic conditions, allowing limited rollout (guided-version) in these unprecedented times.\n\nPart 2 uses a pragmatic RCT (three arms: guided/non-guided/attention-control) testing clinical effectiveness and acceptability to inform clinical practice. If the non-guided intervention is effective (i.e. no psychologist support) it will accelerate the speed of rollout.\n\nMeanwhile through global mental health workshops with stakeholder communities we seek to understand the views of various communities worldwide regarding implementation of this novel intervention form.\n","plannedDates":[{"endDate":"2023-12-03T00:00:00+00:00","startDate":"2021-05-04T00:00:00+00:00","startDateDateOnly":"2021-05-04","endDateDateOnly":"2023-12-03"}],"amountAwarded":910964,"Financial Year":"2020/21","Lead Applicant":"Prof Emily Holmes","grantProgramme":[{"title":"Discretionary Award - Mental Health","title_keyword":"Discretionary Award - Mental Health"}],"Applicant Surname":"Holmes","Partnership Value":910964,"Approval Committee":"Internal Decision Panel","Other Applicant(s)":"Mr Jonathan Kingslake","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:P1vital-Products-Ltd","name":"P1vital Products Ltd","addressCountry":"United Kingdom","id_and_name":"[\"P1vital Products Ltd\", \"360G-Wellcome-ORG:P1vital-Products-Ltd\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:P1vital-Products-Ltd","name":"P1vital Products Ltd"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Can we develop a \"cognitive vaccine\" for intrusive memories of traumatic events from working in the COVID-19 pandemic? A novel and brief intervention to support ICU staff Intensive care unit (ICU) staff face repeated exposure to traumatic work-related events and have reported high levels of posttraumatic symptoms during the pandemic. Novel, scalable and preventative interventions are required.\n\n\nWe are developing a \"cognitive vaccine\" approach for ICU staff against one key symptom \u2013 intrusive memories of traumatic events. These are unwanted, distressing and disrupt functioning.\n\nOur novel, brief gameplay intervention is repeatable, flexible, non-stigmatising, scalable, and driven by mental health science.\n\n\nThis digital intervention is guided by an initial session of psychologist support, then self-administered; delivered same day or months post-trauma, suitable for repeated trauma exposure, fits with busy lives of ICU staff, without discussing trauma detail.\n\n\nPart 1 uses a Bayesian design to optimise and co-develop procedures with ICU professionals and move at speed under pandemic conditions, allowing limited rollout (guided-version) in these unprecedented times.\n\nPart 2 uses a pragmatic RCT (three arms: guided/non-guided/attention-control) testing clinical effectiveness and acceptability to inform clinical practice. If the non-guided intervention is effective (i.e. no psychologist support) it will accelerate the speed of rollout.\n\nMeanwhile through global mental health workshops with stakeholder communities we seek to understand the views of various communities worldwide regarding implementation of this novel intervention form.\n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-223009_Z_21_Z","title":"Combining computational structural biology methods to visualise the dynamics of cell-virus interactions at molecular resolution","Region":"South East","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"223009/Z/21/Z","description":"Archaea are single-celled organisms distinct from bacteria, but that share a number of traits. Like some bacteria, many archaea have a surface layer (S-layer) surrounding the cell, which is a proteinaceous lattice that helps protect the cell from attack from viruses. Understanding how the viruses bind to the S-layer will help us to understand how they infect the cells.\n\nUsing cryo-electron microscopy (cryo-EM), an increasingly popular technique for obtaining structural information about proteins, we will study a variety of archaeal S-layers and some of the viruses that infect them. This data will then be combined with molecular dynamics (MD) for a multiscale investigation of how these S-layer proteins move and interact over time. By solving the structures of the S-layers using cryo-EM, then simulating the interaction of the proteins in the lattice using MD, we push method development to lead the way in cellular structural biology.\n\nWith this work we will develop the understanding of viral entry in archaea, and the structure-function relationship of S-layers which has implications on the evolution of life. Tomography will provide cellular context to structures, and direct the large-scale MD simulations, built up from smaller simulations of atomic structures solved by cryo-EM.\n","plannedDates":[{"endDate":"2024-03-31T00:00:00+00:00","startDate":"2020-10-01T00:00:00+00:00","startDateDateOnly":"2020-10-01","endDateDateOnly":"2024-03-31"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Mx Zo Ford","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Ford","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford","addressCountry":"United Kingdom","id_and_name":"[\"University of Oxford\", \"360G-Wellcome-ORG:University-of-Oxford\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Oxford","name":"University of Oxford"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Combining computational structural biology methods to visualise the dynamics of cell-virus interactions at molecular resolution Archaea are single-celled organisms distinct from bacteria, but that share a number of traits. Like some bacteria, many archaea have a surface layer (S-layer) surrounding the cell, which is a proteinaceous lattice that helps protect the cell from attack from viruses. Understanding how the viruses bind to the S-layer will help us to understand how they infect the cells.\n\nUsing cryo-electron microscopy (cryo-EM), an increasingly popular technique for obtaining structural information about proteins, we will study a variety of archaeal S-layers and some of the viruses that infect them. This data will then be combined with molecular dynamics (MD) for a multiscale investigation of how these S-layer proteins move and interact over time. By solving the structures of the S-layers using cryo-EM, then simulating the interaction of the proteins in the lattice using MD, we push method development to lead the way in cellular structural biology.\n\nWith this work we will develop the understanding of viral entry in archaea, and the structure-function relationship of S-layers which has implications on the evolution of life. Tomography will provide cellular context to structures, and direct the large-scale MD simulations, built up from smaller simulations of atomic structures solved by cryo-EM.\n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222995_Z_21_Z","title":"Novel allosteric modulators of nicotinic acetylcholine receptors implicated in cognitive dysfunction ","Region":"Greater London","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"222995/Z/21/Z","description":"Nicotinic acetylcholine receptor (nAChR) subtypes such as alpha7 and alpha4beta2 have been implicated in a range of psychiatric illnesses, including schizophrenia and Alzheimer\u2019s disease. During the past two decades, the identification of multiple nAChR allosteric modulators (drugs that alter the response of a receptor to its natural agonists) have attracted significant interest. A recent study conducted in this laboratory reported an in silico screening of the DrugBank database against a predicted alpha7 nAChR allosteric site. Amongst the compounds identified in this study, the Na-K-Cl cotransporter inhibitor furosemide was found to be a potent positive allosteric modulator (PAM) of the alpha7 nAChR in electrophysiological assays. The objective of the present project is to expand on our understanding of how the chemical composition of allosteric modulators such as furosemide and its structural analogues influences their allosteric modulatory properties at nAChRs subtypes such as alpha7 and alpha4beta2. I will attempt this via the synthesis of a library of novel compounds (including furosemide analogues). Subsequent electrophysiological and computational (e.g. computer docking) studies of these compounds with respect to their allosteric modulatory activity at the alpha7 and alpha4beta2 nAChRs will be undertaken with the aim of developing a clearer understanding of their structure-activity relationship. \n","plannedDates":[{"endDate":"2023-09-14T00:00:00+00:00","startDate":"2020-09-15T00:00:00+00:00","startDateDateOnly":"2020-09-15","endDateDateOnly":"2023-09-14"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Mr William Goldring","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Goldring","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London","addressCountry":"United Kingdom","id_and_name":"[\"University College London\", \"360G-Wellcome-ORG:University-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Novel allosteric modulators of nicotinic acetylcholine receptors implicated in cognitive dysfunction Nicotinic acetylcholine receptor (nAChR) subtypes such as alpha7 and alpha4beta2 have been implicated in a range of psychiatric illnesses, including schizophrenia and Alzheimer\u2019s disease. During the past two decades, the identification of multiple nAChR allosteric modulators (drugs that alter the response of a receptor to its natural agonists) have attracted significant interest. A recent study conducted in this laboratory reported an in silico screening of the DrugBank database against a predicted alpha7 nAChR allosteric site. Amongst the compounds identified in this study, the Na-K-Cl cotransporter inhibitor furosemide was found to be a potent positive allosteric modulator (PAM) of the alpha7 nAChR in electrophysiological assays. The objective of the present project is to expand on our understanding of how the chemical composition of allosteric modulators such as furosemide and its structural analogues influences their allosteric modulatory properties at nAChRs subtypes such as alpha7 and alpha4beta2. I will attempt this via the synthesis of a library of novel compounds (including furosemide analogues). Subsequent electrophysiological and computational (e.g. computer docking) studies of these compounds with respect to their allosteric modulatory activity at the alpha7 and alpha4beta2 nAChRs will be undertaken with the aim of developing a clearer understanding of their structure-activity relationship. \n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222984_Z_21_Z","title":"iGEM competition 2021","Region":"Scotland","currency":"GBP","awardDate":"2021-01-29T00:00:00+00:00","Internal ID":"222984/Z/21/Z","description":"This grant will support the 2021 International Genetically Engineered Machine Competition (iGEM), by supporting UK undergraduate students from the synthetic biology community to take part in it.\nThe provided funding will be used to support the students\u2019 stipends, some consumable and travel support for the teams that have successfully applied to the competition.\nWellcome has funded the iGEM programme for several years as this is an interesting model to develop interdisciplinary thinking and skills for students. Funding is provided in partnership with BBSRC who also make available a \u00a350k contribution.\nWellcome (Luigi Martino) will be involved at the selection stage and receive a brief report about the respective activities at the end of the year.\n\nCOVID-19 effect on the competition. The hope is that this year\u2019s teams will have the ability to undertake wet-lab-work. If this is made impossible by the potential restricted access to lab spaces, the selected teams will be asked to submit a written proposal reporting the design and strategy to build their chosen genetically engineered machine.","plannedDates":[{"endDate":"2021-12-31T00:00:00+00:00","startDate":"2021-02-01T00:00:00+00:00","startDateDateOnly":"2021-02-01","endDateDateOnly":"2021-12-31"}],"amountAwarded":50000,"Financial Year":"2020/21","Lead Applicant":"Dr Mathis Riehle","grantProgramme":[{"title":"Strategic Support: Science","title_keyword":"Strategic Support: Science"}],"Applicant Surname":"Riehle","Partnership Value":50000,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Glasgow","name":"University of Glasgow","addressCountry":"United Kingdom","id_and_name":"[\"University of Glasgow\", \"360G-Wellcome-ORG:University-of-Glasgow\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Glasgow","name":"University of Glasgow"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"iGEM competition 2021 This grant will support the 2021 International Genetically Engineered Machine Competition (iGEM), by supporting UK undergraduate students from the synthetic biology community to take part in it.\nThe provided funding will be used to support the students\u2019 stipends, some consumable and travel support for the teams that have successfully applied to the competition.\nWellcome has funded the iGEM programme for several years as this is an interesting model to develop interdisciplinary thinking and skills for students. Funding is provided in partnership with BBSRC who also make available a \u00a350k contribution.\nWellcome (Luigi Martino) will be involved at the selection stage and receive a brief report about the respective activities at the end of the year.\n\nCOVID-19 effect on the competition. The hope is that this year\u2019s teams will have the ability to undertake wet-lab-work. If this is made impossible by the potential restricted access to lab spaces, the selected teams will be asked to submit a written proposal reporting the design and strategy to build their chosen genetically engineered machine.","awardDateDateOnly":"2021-01-29","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222963_Z_21_Z","title":"Emergency Efforts to Sustain UK Government Support for ODA","Region":"Greater London","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"222963/Z/21/Z","description":"In the 2020 Spending Review HMG signaled its intent to renege on a manifesto commitment and cut ODA form 0.7 to 0.5% of GNI (on top of the budget cut that happened automatically due to economic contraction). To do this, HMG wishes to repeal the relevant in coming months.\n\nWork to sustain the Government\u2019s support for ODA is already delivering results with an increasingly credible threat of a government rebellion and sustained media interest. However, increasingly our political intel says we may be at risk of winning the vote and losing the argument. Put simply, \u2018hard whipping\u2019 of a rebellion, combined with some horse-trading between different groups, might be enough to carry a vote but it won\u2019t stop the debate flaring back up. This grant would allow us to scale the emergency effort around the legislation while also creating a more enabling environment for the longer team:\n\n\n by bolstering our public affairs capability in Qs 1/ 2,\n by expanding our local organising effort to an additional ten constituencies from Q1-4 and\n by expanding our comms plans from Q1-4.\n \n\n\nA key part of this partnership would be Wellcome\u2019s inclusion in regular political updates, intel and learning sessions.\n","plannedDates":[{"endDate":"2022-02-28T00:00:00+00:00","startDate":"2021-04-01T00:00:00+00:00","startDateDateOnly":"2021-04-01","endDateDateOnly":"2022-02-28"}],"amountAwarded":150000,"Financial Year":"2020/21","Lead Applicant":"Ms Kirsty McNeill","grantProgramme":[{"title":"Discretionary Award - Policy ","title_keyword":"Discretionary Award - Policy "}],"Applicant Surname":"McNeill","Partnership Value":150000,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Save-the-Children","name":"Save the Children","addressCountry":"United Kingdom","id_and_name":"[\"Save the Children\", \"360G-Wellcome-ORG:Save-the-Children\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Save-the-Children","name":"Save the Children"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Emergency Efforts to Sustain UK Government Support for ODA In the 2020 Spending Review HMG signaled its intent to renege on a manifesto commitment and cut ODA form 0.7 to 0.5% of GNI (on top of the budget cut that happened automatically due to economic contraction). To do this, HMG wishes to repeal the relevant in coming months.\n\nWork to sustain the Government\u2019s support for ODA is already delivering results with an increasingly credible threat of a government rebellion and sustained media interest. However, increasingly our political intel says we may be at risk of winning the vote and losing the argument. Put simply, \u2018hard whipping\u2019 of a rebellion, combined with some horse-trading between different groups, might be enough to carry a vote but it won\u2019t stop the debate flaring back up. This grant would allow us to scale the emergency effort around the legislation while also creating a more enabling environment for the longer team:\n\n\n by bolstering our public affairs capability in Qs 1/ 2,\n by expanding our local organising effort to an additional ten constituencies from Q1-4 and\n by expanding our comms plans from Q1-4.\n \n\n\nA key part of this partnership would be Wellcome\u2019s inclusion in regular political updates, intel and learning sessions.\n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222962_Z_21_Z","title":"Targeting individual bromodomain and extra terminal domain (BET) proteins (BRD2-4) to modulate breast cancer angiogenesis","Region":"East Midlands","currency":"GBP","awardDate":"2021-11-01T00:00:00+00:00","Internal ID":"222962/Z/21/Z","description":"Tumour cells requires oxygen and nutrient to grow. As tumours outgrow their existing blood supply they develop regions that have low oxygen (hypoxia) and nutrient levels. These regions are often found in breast cancer and they are associated with resistance to chemotherapy and radiotherapy. Cancer cells exposed to low oxygen release chemical signals that stimulate the growth of new blood vessels which can then deliver the required oxygen and nutrients. There are four Bromodomain and extra terminal (BET) proteins that bind to sections of the DNA that has been chemically modified to indicate if a gene should be active or inactive. The BET proteins then recruit other proteins which are important for transcribing genes. It has been shown that drugs that inhibit the BET proteins change how the cells respond to hypoxia and reduce the growth of new blood vessels.\nI will investigate how the BET proteins regulate the growth of new blood vessels and identify which of the four BET proteins is the best target for new therapies. Regulating blood vessel growth can lead to the reperfusion of tumours and allow radiotherapy and chemotherapy to effectively treat patients with solid tumours.\n\n \n","plannedDates":[{"endDate":"2024-09-30T00:00:00+00:00","startDate":"2020-10-01T00:00:00+00:00","startDateDateOnly":"2020-10-01","endDateDateOnly":"2024-09-30"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Mrs Ashia Wheeler-Crawford","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Wheeler-Crawford","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Nottingham","name":"University of Nottingham","addressCountry":"United Kingdom","id_and_name":"[\"University of Nottingham\", \"360G-Wellcome-ORG:University-of-Nottingham\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Nottingham","name":"University of Nottingham"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Targeting individual bromodomain and extra terminal domain (BET) proteins (BRD2-4) to modulate breast cancer angiogenesis Tumour cells requires oxygen and nutrient to grow. As tumours outgrow their existing blood supply they develop regions that have low oxygen (hypoxia) and nutrient levels. These regions are often found in breast cancer and they are associated with resistance to chemotherapy and radiotherapy. Cancer cells exposed to low oxygen release chemical signals that stimulate the growth of new blood vessels which can then deliver the required oxygen and nutrients. There are four Bromodomain and extra terminal (BET) proteins that bind to sections of the DNA that has been chemically modified to indicate if a gene should be active or inactive. The BET proteins then recruit other proteins which are important for transcribing genes. It has been shown that drugs that inhibit the BET proteins change how the cells respond to hypoxia and reduce the growth of new blood vessels.\nI will investigate how the BET proteins regulate the growth of new blood vessels and identify which of the four BET proteins is the best target for new therapies. Regulating blood vessel growth can lead to the reperfusion of tumours and allow radiotherapy and chemotherapy to effectively treat patients with solid tumours.\n\n \n","awardDateDateOnly":"2021-11-01","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222959_Z_21_Z","title":"A GWAS of the progression of abdominal aortic aneurysms and simultaneous use of genetic and non-genetic information in the evaluation of screening and diagnostic testing pathways","Region":"East Midlands","currency":"GBP","awardDate":"2021-11-01T00:00:00+00:00","Internal ID":"222959/Z/21/Z","description":"In the UK, men aged 65 are invited to screening to check for an Abdominal Aortic Aneurysm (AAA). Untreated aneurysms may rupture, which is usually fatal, although many aneurysms do not progress to this stage. There are known risk factors for AAA such as smoking and family history. Evidence of genetic association with AAA has been found which means that some people are more at risk from birth of having an aneurysm.\n\nI plan to investigate the role of genetics in both the presence and progression of disease, utilising data from UKBiobank, the UK Aneurysm Growth Study and AAA-Express. These findings will be adopted into a hypothetical computer model. I will investigate the possibility of targeted screening for AAA. This involves identification of risk factors that will also consider the benefit of genetic data to identify individuals at high risk of AAA for screening invitation. I will then investigate an adapted clinical pathway after detection of aneurysm based on the risk of rupture. Incorporating genetic information may improve patient outcomes and the cost-effectiveness of the screening program by limiting screening to those most at risk and by ensuring that those diagnosed with an aneurysm have the most appropriate clinical intervention.\n","plannedDates":[{"endDate":"2024-09-27T00:00:00+00:00","startDate":"2020-09-28T00:00:00+00:00","startDateDateOnly":"2020-09-28","endDateDateOnly":"2024-09-27"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Ms Katie Saxby","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Saxby","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester","addressCountry":"United Kingdom","id_and_name":"[\"University of Leicester\", \"360G-Wellcome-ORG:University-of-Leicester\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"A GWAS of the progression of abdominal aortic aneurysms and simultaneous use of genetic and non-genetic information in the evaluation of screening and diagnostic testing pathways In the UK, men aged 65 are invited to screening to check for an Abdominal Aortic Aneurysm (AAA). Untreated aneurysms may rupture, which is usually fatal, although many aneurysms do not progress to this stage. There are known risk factors for AAA such as smoking and family history. Evidence of genetic association with AAA has been found which means that some people are more at risk from birth of having an aneurysm.\n\nI plan to investigate the role of genetics in both the presence and progression of disease, utilising data from UKBiobank, the UK Aneurysm Growth Study and AAA-Express. These findings will be adopted into a hypothetical computer model. I will investigate the possibility of targeted screening for AAA. This involves identification of risk factors that will also consider the benefit of genetic data to identify individuals at high risk of AAA for screening invitation. I will then investigate an adapted clinical pathway after detection of aneurysm based on the risk of rupture. Incorporating genetic information may improve patient outcomes and the cost-effectiveness of the screening program by limiting screening to those most at risk and by ensuring that those diagnosed with an aneurysm have the most appropriate clinical intervention.\n","awardDateDateOnly":"2021-11-01","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222958_Z_21_Z","title":"Assessing the contribution of common and rare short tandem repeats (STRs) to the risk of developing idiopathic pulmonary fibrosis (IPF).","Region":"East Midlands","currency":"GBP","awardDate":"2021-11-01T00:00:00+00:00","Internal ID":"222958/Z/21/Z","description":"Idiopathic Pulmonary Fibrosis (IPF) affects around five people in every 100,000 in the UK and is amongst the most devastating of lung diseases, with a median survival time of 3 years and variable progression. Comparable disease prevalence (6.8 per 100,000 persons) has also been reported in other countries such as the USA, Italy, and Canada. About 5000 cases are detected annually in the UK, and there is rising disease prevalence globally. Despite the substantial disease burden, there is little understanding of the disease etiology, and it has a poor prognosis. Other than a lung transplant, the available drugs are not curative. The majority of cases are diagnosed in patients > 50 years and males are disproportionately affected than females. Both genetic and environmental factors have been associated with IPF. The genetic mutations described so far only account for about 19% of genetic risk associated with IPF. Therefore, the analysis of other types of genetic variations is pertinent. In particular, our study will use whole-genome sequences in case-control cohorts to identify other genetic mutations associated with IPF susceptibility. Identifying risky mutations can help understand disease etiology and develop more targeted therapies.\n","plannedDates":[{"endDate":"2024-09-28T00:00:00+00:00","startDate":"2020-09-29T00:00:00+00:00","startDateDateOnly":"2020-09-29","endDateDateOnly":"2024-09-28"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Mr John Oketch","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Oketch","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester","addressCountry":"United Kingdom","id_and_name":"[\"University of Leicester\", \"360G-Wellcome-ORG:University-of-Leicester\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Assessing the contribution of common and rare short tandem repeats (STRs) to the risk of developing idiopathic pulmonary fibrosis (IPF). Idiopathic Pulmonary Fibrosis (IPF) affects around five people in every 100,000 in the UK and is amongst the most devastating of lung diseases, with a median survival time of 3 years and variable progression. Comparable disease prevalence (6.8 per 100,000 persons) has also been reported in other countries such as the USA, Italy, and Canada. About 5000 cases are detected annually in the UK, and there is rising disease prevalence globally. Despite the substantial disease burden, there is little understanding of the disease etiology, and it has a poor prognosis. Other than a lung transplant, the available drugs are not curative. The majority of cases are diagnosed in patients > 50 years and males are disproportionately affected than females. Both genetic and environmental factors have been associated with IPF. The genetic mutations described so far only account for about 19% of genetic risk associated with IPF. Therefore, the analysis of other types of genetic variations is pertinent. In particular, our study will use whole-genome sequences in case-control cohorts to identify other genetic mutations associated with IPF susceptibility. Identifying risky mutations can help understand disease etiology and develop more targeted therapies.\n","awardDateDateOnly":"2021-11-01","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222956_Z_21_Z","title":"Understanding the genetic basis of radiotherapy toxicity","Region":"East Midlands","currency":"GBP","awardDate":"2021-11-01T00:00:00+00:00","Internal ID":"222956/Z/21/Z","description":"Patients differ in the way they respond to radiation treatment. Approximately 5% of patients are sensitive to radiotherapy and at risk of suffering long-term side-effects (1). However, there is no effective way to identify these patients. The REQUITE trial was established with the aim of reducing long-term side-effects from radiation (2). A total of 4438 cancer patients were enrolled in the study. Before receiving radiotherapy, patients completed a questionnaire and provided a blood sample which was analysed for genetic variants. \nThe researchers tested for other biomarkers that might predict sensitivity to radiation. One example includes the radiation-induced cell death assay called RILA. This is a measure of the percentage of white blood cells that are killed by radiation (3). The researchers found that a low RILA score is associated with long-term side-effects. \nMy research aims include finding possible genetic associations with the RILA assay. In addition to finding possible genetic associations to predict late side-effects in breast cancer patients and a genetic study on patient reported outcome measures such as quality of life scores. The overall long-term goal of this project is to integrate biomarkers, genetic and clinical data to help predict which patients will suffer from worse side-effects. \n \n","plannedDates":[{"endDate":"2024-09-30T00:00:00+00:00","startDate":"2020-10-01T00:00:00+00:00","startDateDateOnly":"2020-10-01","endDateDateOnly":"2024-09-30"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Miss Harkeran Jandu","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Jandu","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester","addressCountry":"United Kingdom","id_and_name":"[\"University of Leicester\", \"360G-Wellcome-ORG:University-of-Leicester\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Understanding the genetic basis of radiotherapy toxicity Patients differ in the way they respond to radiation treatment. Approximately 5% of patients are sensitive to radiotherapy and at risk of suffering long-term side-effects (1). However, there is no effective way to identify these patients. The REQUITE trial was established with the aim of reducing long-term side-effects from radiation (2). A total of 4438 cancer patients were enrolled in the study. Before receiving radiotherapy, patients completed a questionnaire and provided a blood sample which was analysed for genetic variants. \nThe researchers tested for other biomarkers that might predict sensitivity to radiation. One example includes the radiation-induced cell death assay called RILA. This is a measure of the percentage of white blood cells that are killed by radiation (3). The researchers found that a low RILA score is associated with long-term side-effects. \nMy research aims include finding possible genetic associations with the RILA assay. In addition to finding possible genetic associations to predict late side-effects in breast cancer patients and a genetic study on patient reported outcome measures such as quality of life scores. The overall long-term goal of this project is to integrate biomarkers, genetic and clinical data to help predict which patients will suffer from worse side-effects. \n \n","awardDateDateOnly":"2021-11-01","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222955_Z_21_Z","title":"The genetic epidemiology of lung scarring","Region":"East Midlands","currency":"GBP","awardDate":"2021-11-01T00:00:00+00:00","Internal ID":"222955/Z/21/Z","description":"Idiopathic Lung Fibrosis (IPF) is a disease which leads to death three years after diagnosis in half of cases. IPF is a complex genetic disease - variants of DNA that contribute to disease risk have been identified, though we have yet to fully understand how these risk factors lead to lung scarring. \n\nA Genome-Wide Association Study (GWAS) can be used to determine which regions of DNA are associated with disease. GWAS can be used to look at individual variant sites in the DNA called Single Nucleotide Polymorphisms (SNPs). By comparing the entire DNAs (Genomes) of people with and without IPF, we can narrow down the suspected sequences that may contribute to the development of the disease to very fine resolution.\n\nOnce SNPs associated with IPF are identified, we then need to understand why they are associated. Determining which SNP leads to IPF requires 1) Linking SNPs to genes, 2) finding biochemical pathways associated with these genes, and 3) finding drugs that can be used to target the biochemical pathways. These steps enable us to understand the pathology of IPF and could lead to the identification of potential drug treatments for this currently incurable disease. \n","plannedDates":[{"endDate":"2024-09-27T00:00:00+00:00","startDate":"2020-09-28T00:00:00+00:00","startDateDateOnly":"2020-09-28","endDateDateOnly":"2024-09-27"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Mr Daniel Chin","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Chin","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester","addressCountry":"United Kingdom","id_and_name":"[\"University of Leicester\", \"360G-Wellcome-ORG:University-of-Leicester\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"The genetic epidemiology of lung scarring Idiopathic Lung Fibrosis (IPF) is a disease which leads to death three years after diagnosis in half of cases. IPF is a complex genetic disease - variants of DNA that contribute to disease risk have been identified, though we have yet to fully understand how these risk factors lead to lung scarring. \n\nA Genome-Wide Association Study (GWAS) can be used to determine which regions of DNA are associated with disease. GWAS can be used to look at individual variant sites in the DNA called Single Nucleotide Polymorphisms (SNPs). By comparing the entire DNAs (Genomes) of people with and without IPF, we can narrow down the suspected sequences that may contribute to the development of the disease to very fine resolution.\n\nOnce SNPs associated with IPF are identified, we then need to understand why they are associated. Determining which SNP leads to IPF requires 1) Linking SNPs to genes, 2) finding biochemical pathways associated with these genes, and 3) finding drugs that can be used to target the biochemical pathways. These steps enable us to understand the pathology of IPF and could lead to the identification of potential drug treatments for this currently incurable disease. \n","awardDateDateOnly":"2021-11-01","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222954_Z_21_Z","title":"Must the relatives be told? Legal and ethical issues in relation to the non-disclosure of genetic information by healthcare professionals to relatives","Region":"East Midlands","currency":"GBP","awardDate":"2021-11-01T00:00:00+00:00","Internal ID":"222954/Z/21/Z","description":"Genetic information is becoming increasingly utilised by healthcare professionals in order to provide patients with more precise diagnosis and treatments. An individual's genetic information may show their risk of inheriting a genetic disorder, and although most individuals would consent to healthcare professionals sharing their genetic information with relatives who may also be at risk, some individuals refuse. It can be argued that a failure to disclose the risks of inheriting genetic disorders to relatives is ethically wrong, because it restricts the autonomy of individuals to make life choices. Alternatively, it can be contended that it is legally wrong for a healthcare professional to not adhere to the duty of confidentiality that they owe to patients.\n\nThis debate demonstrates the conflict of duties that healthcare professionals face as the use of genetic information in medicine develops, and highlights the need to develop a new legal framework which takes into account the needs of patients, relatives, and healthcare professionals. In order to create an appropriate legal framework, I aim to assess academic commentary, examine case law, and conduct qualitative interviews with healthcare professionals in order to assess scientific opinion, and potentially inform new policy guidance.\n","plannedDates":[{"endDate":"2024-09-27T00:00:00+00:00","startDate":"2020-09-28T00:00:00+00:00","startDateDateOnly":"2020-09-28","endDateDateOnly":"2024-09-27"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Miss Jasmine Blow","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Blow","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester","addressCountry":"United Kingdom","id_and_name":"[\"University of Leicester\", \"360G-Wellcome-ORG:University-of-Leicester\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Leicester","name":"University of Leicester"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Must the relatives be told? Legal and ethical issues in relation to the non-disclosure of genetic information by healthcare professionals to relatives Genetic information is becoming increasingly utilised by healthcare professionals in order to provide patients with more precise diagnosis and treatments. An individual's genetic information may show their risk of inheriting a genetic disorder, and although most individuals would consent to healthcare professionals sharing their genetic information with relatives who may also be at risk, some individuals refuse. It can be argued that a failure to disclose the risks of inheriting genetic disorders to relatives is ethically wrong, because it restricts the autonomy of individuals to make life choices. Alternatively, it can be contended that it is legally wrong for a healthcare professional to not adhere to the duty of confidentiality that they owe to patients.\n\nThis debate demonstrates the conflict of duties that healthcare professionals face as the use of genetic information in medicine develops, and highlights the need to develop a new legal framework which takes into account the needs of patients, relatives, and healthcare professionals. In order to create an appropriate legal framework, I aim to assess academic commentary, examine case law, and conduct qualitative interviews with healthcare professionals in order to assess scientific opinion, and potentially inform new policy guidance.\n","awardDateDateOnly":"2021-11-01","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222949_Z_21_Z","title":"Synthesis and evaluation of novel antagonists and fluorescent ligands for the human P2Y2 receptor","Region":"East Midlands","currency":"GBP","awardDate":"2021-11-01T00:00:00+00:00","Internal ID":"222949/Z/21/Z","description":"The human P2Y2 receptor is one of a large and diverse family of disease-relevant drug targets called G protein-coupled receptors. The P2Y2 receptor is a promising therapeutic target for important conditions, including metastatic cancer. However, no drugs which block the P2Y2 receptor have ever entered clinical trials.\n\nThe research group recently published an initial study where novel P2Y2 receptor inhibitors, that prevent the action of the receptor, with good biological activity were produced. The project will build on this previous work to design, synthesise and evaluate further inhibitors with improved biological activity and drug-like properties to make them more clinically viable. The design of these inhibitors will be driven by visualisation of key interactions with the P2Y2 receptor in computational models. Another subsequent part of the project will involve equipping these novel inhibitors with a light emitting fluorescent dye that can be used to investigate their interaction with the P2Y2 receptor in cell and tissue-based experiments with state of the art imaging equipment. \n\nNovel, high affinity and drug-like P2Y2 receptor inhibitors and their fluorescently-labelled counterparts would provide a vital tool to further validate the role of P2Y2 in disease and aid in the development of clinically viable drugs.\n\n \n\n \n","plannedDates":[{"endDate":"2024-09-30T00:00:00+00:00","startDate":"2020-10-01T00:00:00+00:00","startDateDateOnly":"2020-10-01","endDateDateOnly":"2024-09-30"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Miss Rebecca Knight","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Knight","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Nottingham","name":"University of Nottingham","addressCountry":"United Kingdom","id_and_name":"[\"University of Nottingham\", \"360G-Wellcome-ORG:University-of-Nottingham\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Nottingham","name":"University of Nottingham"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Synthesis and evaluation of novel antagonists and fluorescent ligands for the human P2Y2 receptor The human P2Y2 receptor is one of a large and diverse family of disease-relevant drug targets called G protein-coupled receptors. The P2Y2 receptor is a promising therapeutic target for important conditions, including metastatic cancer. However, no drugs which block the P2Y2 receptor have ever entered clinical trials.\n\nThe research group recently published an initial study where novel P2Y2 receptor inhibitors, that prevent the action of the receptor, with good biological activity were produced. The project will build on this previous work to design, synthesise and evaluate further inhibitors with improved biological activity and drug-like properties to make them more clinically viable. The design of these inhibitors will be driven by visualisation of key interactions with the P2Y2 receptor in computational models. Another subsequent part of the project will involve equipping these novel inhibitors with a light emitting fluorescent dye that can be used to investigate their interaction with the P2Y2 receptor in cell and tissue-based experiments with state of the art imaging equipment. \n\nNovel, high affinity and drug-like P2Y2 receptor inhibitors and their fluorescently-labelled counterparts would provide a vital tool to further validate the role of P2Y2 in disease and aid in the development of clinically viable drugs.\n\n \n\n \n","awardDateDateOnly":"2021-11-01","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222914_Z_21_Z","title":"Learning Data Driven Medical Checklists For Multi-Disciplinary Consult Scheduling","Region":"International","currency":"GBP","awardDate":"2021-03-31T00:00:00+00:00","Internal ID":"222914/Z/21/Z","description":"Checklists are simple tools that are often used to promote safety in clinical applications, because they can easily be integrated into a clinical workflow deployment without the need for extensive training or additional technology. Currently, machine learning in health focuses on large, complex deep neural networks. In comparison with deep neural networks, checklists are far easier to use, understand, and scrutinize. In practice, checklists are difficult to develop, and the vast majority of real-world checklists are hand-crafted by panels of experts.\n\nGiven the widespread integration of electronic health data over the past decade, our goal is to learn checklists from data for clinical tasks. The main application of our method, in partnership with Dr. Leo Celi at Beth Israel Deaconess Medical Center (BIDMC) in Boston, is to predict mortality in patients eligible for Continuous Renal Replacement Therapy (CRRT).\n\nA generated checklist for CRRT is clinically desirable in the intensive care unit as a mechanism to trigger a multidisciplinary discussion with the patient\u2019s family, to consider the value of the treatment weighed against the physical burden and cost. Thus we include operational considerations such as number of items in the checklist, the false negative/positive rate tradeoff, and fairness across protected groups. \n \n","plannedDates":[{"endDate":"2022-07-14T00:00:00+00:00","startDate":"2021-04-15T00:00:00+00:00","startDateDateOnly":"2021-04-15","endDateDateOnly":"2022-07-14"}],"amountAwarded":79188,"Financial Year":"2020/21","Lead Applicant":"Dr Marzyeh Ghassemi","grantProgramme":[{"title":"Discretionary Award \u2013 DSH","title_keyword":"Discretionary Award \u2013 DSH"}],"Applicant Surname":"Ghassemi","Partnership Value":79188,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-Toronto","name":"University of Toronto","addressCountry":"Canada","id_and_name":"[\"University of Toronto\", \"360G-Wellcome-ORG:University-of-Toronto\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-Toronto","name":"University of Toronto"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Learning Data Driven Medical Checklists For Multi-Disciplinary Consult Scheduling Checklists are simple tools that are often used to promote safety in clinical applications, because they can easily be integrated into a clinical workflow deployment without the need for extensive training or additional technology. Currently, machine learning in health focuses on large, complex deep neural networks. In comparison with deep neural networks, checklists are far easier to use, understand, and scrutinize. In practice, checklists are difficult to develop, and the vast majority of real-world checklists are hand-crafted by panels of experts.\n\nGiven the widespread integration of electronic health data over the past decade, our goal is to learn checklists from data for clinical tasks. The main application of our method, in partnership with Dr. Leo Celi at Beth Israel Deaconess Medical Center (BIDMC) in Boston, is to predict mortality in patients eligible for Continuous Renal Replacement Therapy (CRRT).\n\nA generated checklist for CRRT is clinically desirable in the intensive care unit as a mechanism to trigger a multidisciplinary discussion with the patient\u2019s family, to consider the value of the treatment weighed against the physical burden and cost. Thus we include operational considerations such as number of items in the checklist, the false negative/positive rate tradeoff, and fairness across protected groups. \n \n","awardDateDateOnly":"2021-03-31","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222908_Z_21_Z","title":"Liquid-phase Transmission Electron microscopy of RNA polymerase dynamics","Region":"Greater London","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"222908/Z/21/Z","description":"Proteins control most cellular functions, made possible by their unique and diverse range of 3D structures and the dynamics within them. Methods to determine protein structure have revolutionised the understanding of cell function and dysfunction on the molecular level as well as drug design, however, these methods generally require static molecules. One rapidly developing method to probe protein structure uses transmission electron microscopy to take highly magnified images of cryogenically frozen proteins which can be computationally combined into a 3D model, however, freezing the sample prevents any real-time dynamics. We aim to optimise this method with new liquid-phase transmission electron microscopy technology, to film and understand structural dynamics of proteins in real-time in solution. This will require the development of electron microscopy techniques to image the protein clearly, image processing techniques to analyse the movies taken and molecular dynamics to understand and verify the results seen. We, therefore, aim to develop liquid-phase transmission electron microscopy as a technique to probe protein dynamics in solution, allowing the study of protein function, dysfunction and dynamic responses to stimuli, for example, drug binding. This will focus on RNA polymerase as a model system with physiologically relevant dynamics. \n","plannedDates":[{"endDate":"2023-12-22T00:00:00+00:00","startDate":"2020-12-23T00:00:00+00:00","startDateDateOnly":"2020-12-23","endDateDateOnly":"2023-12-22"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Mr Gabriel Ing","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Ing","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London","addressCountry":"United Kingdom","id_and_name":"[\"University College London\", \"360G-Wellcome-ORG:University-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-College-London","name":"University College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Liquid-phase Transmission Electron microscopy of RNA polymerase dynamics Proteins control most cellular functions, made possible by their unique and diverse range of 3D structures and the dynamics within them. Methods to determine protein structure have revolutionised the understanding of cell function and dysfunction on the molecular level as well as drug design, however, these methods generally require static molecules. One rapidly developing method to probe protein structure uses transmission electron microscopy to take highly magnified images of cryogenically frozen proteins which can be computationally combined into a 3D model, however, freezing the sample prevents any real-time dynamics. We aim to optimise this method with new liquid-phase transmission electron microscopy technology, to film and understand structural dynamics of proteins in real-time in solution. This will require the development of electron microscopy techniques to image the protein clearly, image processing techniques to analyse the movies taken and molecular dynamics to understand and verify the results seen. We, therefore, aim to develop liquid-phase transmission electron microscopy as a technique to probe protein dynamics in solution, allowing the study of protein function, dysfunction and dynamic responses to stimuli, for example, drug binding. This will focus on RNA polymerase as a model system with physiologically relevant dynamics. \n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222906_Z_21_Z","title":"Structural and mechanistic investigations of the SWI/SNF chromatin remodeller","Region":"Greater London","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"222906/Z/21/Z","description":"Packaging the two metres of chromosomal DNA found in every human cell is achieved by wrapping DNA around histone proteins in complexes called nucleosomes. Generally, DNA wrapped within nucleosomes is rendered inaccessible to enzymes and DNA-binding factors involved in normal DNA processes such as gene expression, DNA damage repair and chromosome replication. Chromatin remodellers are large molecular machines that disrupt the interaction between DNA and histones, exposing the DNA and therefore making it accessible for fundamental biological processes. I will be focussing on a particular chromatin remodeller called SWI/SNF that uses chemical energy to move, modify and eject nucleosomes. Around 20% of human tumours have been shown to have mutated SWI/SNF, highlighting the complex as one of the most commonly affected targets in cancer. The aim of my project is to use structural (cryo-EM) and single molecule (FRET) analysis to probe the molecular details of the interaction of SWI/SNF with the nucleosome. Moreover, we will visualise SWI/SNF in action, in an attempt to understand how the machine remodels nucleosomes and leading to further understanding of its role in cancer. Our results will provide a platform for the future development of drugs that specifically target mutated SWI/SNF complexes in numerous cancers.\n","plannedDates":[{"endDate":"2023-12-22T00:00:00+00:00","startDate":"2020-12-23T00:00:00+00:00","startDateDateOnly":"2020-12-23","endDateDateOnly":"2023-12-22"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Miss Debbie Woods","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Woods","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Birkbeck-University-of-London","name":"Birkbeck University of London","addressCountry":"United Kingdom","id_and_name":"[\"Birkbeck University of London\", \"360G-Wellcome-ORG:Birkbeck-University-of-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Birkbeck-University-of-London","name":"Birkbeck University of London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Structural and mechanistic investigations of the SWI/SNF chromatin remodeller Packaging the two metres of chromosomal DNA found in every human cell is achieved by wrapping DNA around histone proteins in complexes called nucleosomes. Generally, DNA wrapped within nucleosomes is rendered inaccessible to enzymes and DNA-binding factors involved in normal DNA processes such as gene expression, DNA damage repair and chromosome replication. Chromatin remodellers are large molecular machines that disrupt the interaction between DNA and histones, exposing the DNA and therefore making it accessible for fundamental biological processes. I will be focussing on a particular chromatin remodeller called SWI/SNF that uses chemical energy to move, modify and eject nucleosomes. Around 20% of human tumours have been shown to have mutated SWI/SNF, highlighting the complex as one of the most commonly affected targets in cancer. The aim of my project is to use structural (cryo-EM) and single molecule (FRET) analysis to probe the molecular details of the interaction of SWI/SNF with the nucleosome. Moreover, we will visualise SWI/SNF in action, in an attempt to understand how the machine remodels nucleosomes and leading to further understanding of its role in cancer. Our results will provide a platform for the future development of drugs that specifically target mutated SWI/SNF complexes in numerous cancers.\n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222905_Z_21_Z","title":"Structural Investigations of Sodium Channel Mutations Associated with Neurological Diseases","Region":"Greater London","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"222905/Z/21/Z","description":"Sodium channels (Navs) are proteins which are found in cells around the body, including the central and peripheral nervous system and heart muscles. These proteins span the cell membrane and form channels which specifically allows sodium ions to cross the membrane under certain conditions. This influx of sodium ions in neurons is responsible for information processing and is critical for nervous system function. Genetic mutations in Navs can cause multiple diseases including epilepsy, chronic pain and cardiac arrhythmias. Generally, these mutations reduce the function of Navs, disrupting the balance of information, for example in the brain sometimes resulting in epilepsy. Specific drugs therefore need to be developed in order to re-establish this balance either by adding to Navs\u2019 functionality or reducing it. We aim to use structural biology techniques, including x-ray crystallography and potentially cryo-EM to visualise potential drug binding sites. We will also look at common disease-causing mutations allowing us to identify drugs which will not only target a specific subtype of Nav but also a specific mutation. In particular we will be looking at repurposing already commercially available drugs. This work has the potential to identify drugs for Nav related diseases and provide new treatment options for patients.\n \n","plannedDates":[{"endDate":"2023-12-22T00:00:00+00:00","startDate":"2020-12-23T00:00:00+00:00","startDateDateOnly":"2020-12-23","endDateDateOnly":"2023-12-22"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Miss Frances Thomas","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Thomas","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Birkbeck-University-of-London","name":"Birkbeck University of London","addressCountry":"United Kingdom","id_and_name":"[\"Birkbeck University of London\", \"360G-Wellcome-ORG:Birkbeck-University-of-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Birkbeck-University-of-London","name":"Birkbeck University of London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Structural Investigations of Sodium Channel Mutations Associated with Neurological Diseases Sodium channels (Navs) are proteins which are found in cells around the body, including the central and peripheral nervous system and heart muscles. These proteins span the cell membrane and form channels which specifically allows sodium ions to cross the membrane under certain conditions. This influx of sodium ions in neurons is responsible for information processing and is critical for nervous system function. Genetic mutations in Navs can cause multiple diseases including epilepsy, chronic pain and cardiac arrhythmias. Generally, these mutations reduce the function of Navs, disrupting the balance of information, for example in the brain sometimes resulting in epilepsy. Specific drugs therefore need to be developed in order to re-establish this balance either by adding to Navs\u2019 functionality or reducing it. We aim to use structural biology techniques, including x-ray crystallography and potentially cryo-EM to visualise potential drug binding sites. We will also look at common disease-causing mutations allowing us to identify drugs which will not only target a specific subtype of Nav but also a specific mutation. In particular we will be looking at repurposing already commercially available drugs. This work has the potential to identify drugs for Nav related diseases and provide new treatment options for patients.\n \n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222888_Z_21_Z","title":"Generative models for biological methods of control","Region":"Greater London","currency":"GBP","awardDate":"2021-06-30T00:00:00+00:00","Internal ID":"222888/Z/21/Z","description":"Behavioural phenotypes are highly relevant to many diseases, particularly those involving neurodegeneration, such as Friedreich\u2019s Ataxia or Parkinson\u2019s disease. While these behavioural phenotypes arise from low-level molecular and cellular processes, they are highly complex. As a result, identifying structure within behavioural data can be challenging. Generative models are a type of model which are able to generate new instances of data, unlike discriminative models which can only discriminate between existing instances. As a result, these models must solve the more complex problem of whether a given data instance is likely, as opposed to what classification it most likely belongs to. This means they must learn the underlying distributions of the data itself, often capturing more meaningful correlations as a result. Building generative models of behaviour can therefore offer deeper insight into the structure of behaviour, as well as a means of analysis through synthesis, where the ability of a model to successfully reproduce naturally observed behaviour provides further validation of the model. These models can also be used to investigate the impact of disease on behaviour through attempts to \u2018corrupt\u2019 the model\u2019s underlying processes and compare the output to experimental data obtained from individuals with a particular disease.\n\n\n \n","plannedDates":[{"endDate":"2023-11-30T00:00:00+00:00","startDate":"2020-12-01T00:00:00+00:00","startDateDateOnly":"2020-12-01","endDateDateOnly":"2023-11-30"}],"amountAwarded":0,"Financial Year":"2020/21","Lead Applicant":"Mr Max Grogan","grantProgramme":[{"title":"PhD Studentship (Basic)","title_keyword":"PhD Studentship (Basic)"}],"Applicant Surname":"Grogan","Partnership Value":0,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Imperial-College-London","name":"Imperial College London","addressCountry":"United Kingdom","id_and_name":"[\"Imperial College London\", \"360G-Wellcome-ORG:Imperial-College-London\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Imperial-College-London","name":"Imperial College London"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Generative models for biological methods of control Behavioural phenotypes are highly relevant to many diseases, particularly those involving neurodegeneration, such as Friedreich\u2019s Ataxia or Parkinson\u2019s disease. While these behavioural phenotypes arise from low-level molecular and cellular processes, they are highly complex. As a result, identifying structure within behavioural data can be challenging. Generative models are a type of model which are able to generate new instances of data, unlike discriminative models which can only discriminate between existing instances. As a result, these models must solve the more complex problem of whether a given data instance is likely, as opposed to what classification it most likely belongs to. This means they must learn the underlying distributions of the data itself, often capturing more meaningful correlations as a result. Building generative models of behaviour can therefore offer deeper insight into the structure of behaviour, as well as a means of analysis through synthesis, where the ability of a model to successfully reproduce naturally observed behaviour provides further validation of the model. These models can also be used to investigate the impact of disease on behaviour through attempts to \u2018corrupt\u2019 the model\u2019s underlying processes and compare the output to experimental data obtained from individuals with a particular disease.\n\n\n \n","awardDateDateOnly":"2021-06-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222887_Z_21_Z","title":"UCH photography exhibition","Region":"Greater London","currency":"GBP","awardDate":"2021-01-29T00:00:00+00:00","Internal ID":"222887/Z/21/Z","description":"Produce, print and install an exhibition of photographs by Tom Pilston documenting University College Hospital (UCH) staff working on the Covid pandemic. 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Exhibtion to be in UCH lobby in Euston Road \n","awardDateDateOnly":"2021-01-29","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222884_Z_21_Z","title":"Advancing product development and use of monoclonal antibodies for infectious disease in low and middle income countries (LMICs)\u2019","Region":"International","currency":"GBP","awardDate":"2020-09-30T00:00:00+00:00","Internal ID":"222884/Z/21/Z","description":"The project supports activities in the Immunization, Vaccines and biologicals\ndepartment of the WHO that aim to advance the product development and use of\nmonoclonal antibodies (mAbs) for infectious diseases, with a focus on meeting the\nneeds of Low and Middle Income Countries (LMICs). Three specific activities will be\ncarried out. First, a stakeholder consultation on monoclonal antibody technologies will\nbe held to discuss which would best support affordability and accessibility in LMICs.\nSecond, an application to establish rabies mAbs on the WHO model list of essential\nmedicines (EML) would set the precedent for inclusion of additional infectious diseases\nmAbs in the future. Thirdly, an assessment of diphtheria immunoglobulin supply and\npotential demand for mAb-based products will be carried out which could serve as a\nmethodology to be used to assess other mAb based products.\"","plannedDates":[{"endDate":"2022-11-28T00:00:00+00:00","startDate":"2021-06-01T00:00:00+00:00","startDateDateOnly":"2021-06-01","endDateDateOnly":"2022-11-28"}],"amountAwarded":143272,"Financial Year":"2019/20","Lead Applicant":"Dr Birgitte Giersing","grantProgramme":[{"title":"Innovations AIGH Enterics Flagship ","title_keyword":"Innovations AIGH Enterics Flagship "}],"Applicant Surname":"Giersing","Partnership Value":143272,"Approval Committee":"Internal Decision Panel","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:World-Health-Organization-Switzerland","name":"World Health Organization, Switzerland","addressCountry":"Switzerland","id_and_name":"[\"World Health Organization, Switzerland\", \"360G-Wellcome-ORG:World-Health-Organization-Switzerland\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:World-Health-Organization-Switzerland","name":"World Health Organization, Switzerland"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Advancing product development and use of monoclonal antibodies for infectious disease in low and middle income countries (LMICs)\u2019 The project supports activities in the Immunization, Vaccines and biologicals\ndepartment of the WHO that aim to advance the product development and use of\nmonoclonal antibodies (mAbs) for infectious diseases, with a focus on meeting the\nneeds of Low and Middle Income Countries (LMICs). Three specific activities will be\ncarried out. First, a stakeholder consultation on monoclonal antibody technologies will\nbe held to discuss which would best support affordability and accessibility in LMICs.\nSecond, an application to establish rabies mAbs on the WHO model list of essential\nmedicines (EML) would set the precedent for inclusion of additional infectious diseases\nmAbs in the future. Thirdly, an assessment of diphtheria immunoglobulin supply and\npotential demand for mAb-based products will be carried out which could serve as a\nmethodology to be used to assess other mAb based products.\"","awardDateDateOnly":"2020-09-30","dataset":{"title":"Grants awarded from 1 October 2005 to 30 June 2021","issued":"2018-03-21","license":"https://creativecommons.org/licenses/by/4.0/","modified":"2021-09-09T14:07:48.000+0000","publisher":{"logo":"https://www.threesixtygiving.org/wp-content/uploads/wellcome-logo-black.png","name":"The Wellcome Trust","org_id":"GB-CHC-210183","prefix":"360G-wellcome","website":"https://wellcome.org/","last_published":"2021-11-01"},"identifier":"a001p00000xQ047AAC","description":"","distribution":[{"title":"Grants awarded from 1 October 2005 to 30 June 2021","accessURL":"https://wellcome.org/grant-funding/funded-people-and-projects","downloadURL":"https://cms.wellcome.org/sites/default/files/2021-09/Wellcome-grants-awarded-1-October-2005-to-30-June-2021-as-at-12072021_0.xlsx"}],"license_name":"Creative Commons Attribution 4.0 International (CC BY 4.0)","datagetter_metadata":{"json":"/home/datastore/latest_datagetter//data/json_all/a001p00000xQ047AAC.json","valid":true,"downloads":true,"file_size":11335757,"file_type":"xlsx","acceptable_license":true,"datetime_downloaded":"2022-06-23T00:05:59+01:00"}}} +{"id":"360G-Wellcome-222874_Z_21_Z","title":"Doing natality: making babies, making kin in Africa","Region":"International","currency":"GBP","awardDate":"2021-03-15T00:00:00+00:00","Internal ID":"222874/Z/21/Z","description":"Africa has the fastest growing population in the world. At the same time the continent has some of the highest rates of infertility. Most people long to have children for diverse reasons. Those unable to have children seek ways to improve their chances of conceiving. These may include biomedical interventions, vernacular healing practices, changing or adding partners or making kin through adoption and child circulation. Yet despite the diversity of lived experiences and practices of reproduction across the continent, most research and interventions into reproductive health in Africa frame it primarily in terms of risk, pathology, mortality, and irresponsibility. Doing Natality engages a team from four African countries, working across demography, social sciences, medical humanities and science and technology studies, to develop a research agenda that centers the notion of \"doing natality\". We aim to explore practices of doing natality as articulation of love, care, beginning something new and securing better futures in raising children. We thereby open up a new space to interrogate and explore the usefulness of the notion of \"doing natality\" as heuristic, theoretical and methodological tool by asking what it means for African women, men and couples to have (or not have) children.\n \n","plannedDates":[{"endDate":"2026-08-31T00:00:00+00:00","startDate":"2021-09-01T00:00:00+00:00","startDateDateOnly":"2021-09-01","endDateDateOnly":"2026-08-31"}],"amountAwarded":1064246,"Financial Year":"2020/21","Lead Applicant":"Dr Nozipho Nolwazi Mkhwanazi","grantProgramme":[{"title":"Research Development Award in H&SS","title_keyword":"Research Development Award in H&SS"}],"Applicant Surname":"Mkhwanazi","Partnership Value":1064246,"Approval Committee":"Research Development Awards Committee","Other Applicant(s)":"Prof Richard Rottenburg","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:University-of-the-Witwatersrand","name":"University of the Witwatersrand","addressCountry":"South Africa","id_and_name":"[\"University of the Witwatersrand\", \"360G-Wellcome-ORG:University-of-the-Witwatersrand\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:University-of-the-Witwatersrand","name":"University of the Witwatersrand"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Doing natality: making babies, making kin in Africa Africa has the fastest growing population in the world. At the same time the continent has some of the highest rates of infertility. Most people long to have children for diverse reasons. Those unable to have children seek ways to improve their chances of conceiving. These may include biomedical interventions, vernacular healing practices, changing or adding partners or making kin through adoption and child circulation. Yet despite the diversity of lived experiences and practices of reproduction across the continent, most research and interventions into reproductive health in Africa frame it primarily in terms of risk, pathology, mortality, and irresponsibility. Doing Natality engages a team from four African countries, working across demography, social sciences, medical humanities and science and technology studies, to develop a research agenda that centers the notion of \"doing natality\". We aim to explore practices of doing natality as articulation of love, care, beginning something new and securing better futures in raising children. 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We will empower disabled people as agents of change and our activities will include a range of fellowships for disabled people and a highly innovative research training course led by disabled people. Our network will reinvent how universities work with disabled people, in addition to methodological and epistemological development.\n","plannedDates":[{"endDate":"2026-07-31T00:00:00+00:00","startDate":"2021-08-01T00:00:00+00:00","startDateDateOnly":"2021-08-01","endDateDateOnly":"2026-07-31"}],"amountAwarded":1040680,"Financial Year":"2020/21","Lead Applicant":"Dr Ben Simmons","grantProgramme":[{"title":"Research Development Award in H&SS","title_keyword":"Research Development Award in H&SS"}],"Applicant Surname":"Simmons","Partnership Value":1040680,"Approval Committee":"Research Development Awards Committee","Other Applicant(s)":"Dr Stuart Read, Prof Martin Levinson","fundingOrganization":[{"id":"GB-CHC-210183","name":"The Wellcome Trust","id_and_name":"[\"The Wellcome Trust\", \"GB-CHC-210183\"]"}],"recipientOrganization":[{"id":"360G-Wellcome-ORG:Bath-Spa-University","name":"Bath Spa University","addressCountry":"United Kingdom","id_and_name":"[\"Bath Spa University\", \"360G-Wellcome-ORG:Bath-Spa-University\"]"}],"additional_data":{"locationLookup":[],"TSGFundingOrgType":"Grantmaking Organisation","fundingOrganizationCanonical":{"id":"GB-CHC-210183","name":"The Wellcome Trust"},"recipientOrganizationCanonical":{"id":"360G-Wellcome-ORG:Bath-Spa-University","name":"Bath Spa University"}},"filename":"a001p00000xQ047AAC.json","title_and_description":"Setting an Emancipatory Agenda: Disabled People's Research Network Social science research has long been criticised for failing to improve the life chances of disabled people. Current research agendas are determined \u2018top down\u2019 by policy makers, and researchers risk objectifying disabled participants by conducting research \u2018on\u2019 them (as opposed to \u2018with\u2019 them). Our radical and exciting proposal challenges the status quo by developing an inclusive agenda and establishing a Disabled People\u2019s Research Network. Our vision is to place academic and non-academic disabled people at the heart of research development, and our entire project will be co-produced by working with disabled people\u2019s organisations. Our activities will identify new salient questions and reinvent social science methodology by exploring how the arts and humanities can enable disabled people to evidence and share their lived experiences. We will develop more inclusive forms of knowledge exchange between universities and disabled people, and we will work with policy makers to maximise disabled people\u2019s research impact. 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